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Search of human proteins with 157738613
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2
[Homo sapiens]
(835 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2 [... 1597 0.0
gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1 [... 1579 0.0
gi|157738611 coiled-coil alpha-helical rod protein 1 isoform 3 [... 1391 0.0
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 119 2e-26
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 119 2e-26
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 119 2e-26
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 119 2e-26
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 119 2e-26
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 119 2e-26
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 119 2e-26
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 119 2e-26
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 118 2e-26
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 118 2e-26
gi|148746195 trichohyalin [Homo sapiens] 115 2e-25
gi|16262452 cingulin [Homo sapiens] 114 5e-25
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 109 9e-24
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 109 1e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 108 3e-23
gi|45439327 periplakin [Homo sapiens] 107 6e-23
gi|21735548 centrosomal protein 2 [Homo sapiens] 106 8e-23
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 106 1e-22
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 106 1e-22
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 106 1e-22
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 105 2e-22
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 104 4e-22
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 103 5e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 103 7e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 103 7e-22
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 103 7e-22
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 103 7e-22
>gi|157738613 coiled-coil alpha-helical rod protein 1 isoform 2
[Homo sapiens]
Length = 835
Score = 1597 bits (4136), Expect = 0.0
Identities = 835/835 (100%), Positives = 835/835 (100%)
Query: 1 MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA 60
MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA
Sbjct: 1 MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA 60
Query: 61 RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGHQDVSERRLDTQRPQVTMWERDVSS 120
RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGHQDVSERRLDTQRPQVTMWERDVSS
Sbjct: 61 RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGHQDVSERRLDTQRPQVTMWERDVSS 120
Query: 121 DRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAM 180
DRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAM
Sbjct: 121 DRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAM 180
Query: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 240
ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE
Sbjct: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 240
Query: 241 EALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVE 300
EALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVE
Sbjct: 241 EALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVE 300
Query: 301 NLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILAL 360
NLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILAL
Sbjct: 301 NLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILAL 360
Query: 361 QEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVA 420
QEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVA
Sbjct: 361 QEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVA 420
Query: 421 SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE 480
SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE
Sbjct: 421 SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE 480
Query: 481 QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQL 540
QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQL
Sbjct: 481 QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQL 540
Query: 541 RQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKV 600
RQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKV
Sbjct: 541 RQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKV 600
Query: 601 AQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAE 660
AQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAE
Sbjct: 601 AQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAE 660
Query: 661 VETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQ 720
VETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQ
Sbjct: 661 VETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQ 720
Query: 721 RLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSAS 780
RLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSAS
Sbjct: 721 RLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSAS 780
Query: 781 APVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDRCSSSNPQMSS 835
APVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDRCSSSNPQMSS
Sbjct: 781 APVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDRCSSSNPQMSS 835
>gi|157738615 coiled-coil alpha-helical rod protein 1 isoform 1
[Homo sapiens]
Length = 871
Score = 1579 bits (4089), Expect = 0.0
Identities = 835/871 (95%), Positives = 835/871 (95%), Gaps = 36/871 (4%)
Query: 1 MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA 60
MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA
Sbjct: 1 MWPHSAGARPWASTLTGKDPRVMACWCLDGLPSGLAEPWRELWRWRSRPLHCVPPFSPLA 60
Query: 61 RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSG------------------------- 95
RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSG
Sbjct: 61 RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGSTGLIPPSHFQARPLSTLPRMAPTW 120
Query: 96 -----------HQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA 144
HQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA
Sbjct: 121 LSDIPLVQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA 180
Query: 145 EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA 204
EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA
Sbjct: 181 EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA 240
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 264
GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR
Sbjct: 241 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 300
Query: 265 AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ 324
AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ
Sbjct: 301 AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ 360
Query: 325 KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ 384
KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ
Sbjct: 361 KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQ 420
Query: 385 SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA 444
SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA
Sbjct: 421 SLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKA 480
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE
Sbjct: 481 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 540
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE
Sbjct: 541 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 600
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV
Sbjct: 601 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 660
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA
Sbjct: 661 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 720
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG
Sbjct: 721 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 780
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL 804
LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL
Sbjct: 781 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL 840
Query: 805 QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS 835
QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS
Sbjct: 841 QDLSEAISKEEAVCQGDNLDRCSSSNPQMSS 871
>gi|157738611 coiled-coil alpha-helical rod protein 1 isoform 3
[Homo sapiens]
Length = 782
Score = 1391 bits (3600), Expect = 0.0
Identities = 742/750 (98%), Positives = 746/750 (99%)
Query: 86 NNVEMFPPSGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAE 145
+++ + P GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAE
Sbjct: 33 SDIPLVQPPGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAE 92
Query: 146 VIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAG 205
VIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAG
Sbjct: 93 VIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAG 152
Query: 206 AEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRA 265
AEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRA
Sbjct: 153 AEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRA 212
Query: 266 GEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQK 325
GEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQK
Sbjct: 213 GEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQK 272
Query: 326 LLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQS 385
LLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQS
Sbjct: 273 LLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQS 332
Query: 386 LLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAA 445
LLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAA
Sbjct: 333 LLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAA 392
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG
Sbjct: 393 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 452
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREER 565
AAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREER
Sbjct: 453 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREER 512
Query: 566 NRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVA 625
NRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVA
Sbjct: 513 NRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVA 572
Query: 626 RQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAK 685
RQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAK
Sbjct: 573 RQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAK 632
Query: 686 AVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGL 745
AVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGL
Sbjct: 633 AVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGL 692
Query: 746 LSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQ 805
LSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQ
Sbjct: 693 LSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQ 752
Query: 806 DLSEAISKEEAVCQGDNLDRCSSSNPQMSS 835
DLSEAISKEEAVCQGDNLDRCSSSNPQMSS
Sbjct: 753 DLSEAISKEEAVCQGDNLDRCSSSNPQMSS 782
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 119 bits (297), Expect = 2e-26
Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)
Query: 142 QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 201
+QAE+ + ++L EE R E +Q+ + E +A AR KA E E L+A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2016
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
+ A +R+ E+ S R+L+ Q Q++L + +AH A+ + + + S+
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 262 TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 321
+ GEA+ A EAE R Q + QV E L++ EQ + +Q
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2132
Query: 322 ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 381
A AE L+ + A E+ R+ Q +D+ E E +
Sbjct: 2133 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2171
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 439
K R + +V + L+ Q LE +D K L L E++ E +A QRS
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2224
Query: 440 LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 499
+VE E + ELS+ + E L++ ++Q +L+
Sbjct: 2225 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2269
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 559
K++ A + RLS A ++ +R L LA + E + E
Sbjct: 2270 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2316
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
Q +E RL AE A L+QQ+ A+EQ ++ ++AQQL +E Q Q +
Sbjct: 2317 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2367
Query: 620 LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
LE RQ Q E + EA L+ + + QA E+ A+ + E++ + R A
Sbjct: 2368 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 738
+E V +L ++++ + ER +E + L+ E KE+ Q+ A+ LQ K+ +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2477
Query: 739 TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
T+QQE LL + QQ L+ SLL +++ + E VA A RE +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537
Query: 797 LSVLLDDLQDLSEAISKEEA 816
+ + Q L S EEA
Sbjct: 2538 QQQMEQERQRL--VASMEEA 2555
Score = 114 bits (284), Expect = 5e-25
Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)
Query: 124 EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 168
E G + R E L ++A ++ QEL R E EV L R TS
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Query: 169 LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 228
+ K RLEA+A LA EA LRA A+ R+ EE + R+ E +R+
Sbjct: 1783 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835
Query: 229 QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 283
E+L+++ T+ EA +L K E + L L A + + L E AQ +A++ +
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 284 --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 333
QL K + +LE Q LVE+ R+ V E++ S + + E + L ++
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
ED AEL R + L + E +VQ S + E E R+ ++ L
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 445
+ + +E +S +QL+ + Q+++ ++ Q++ LQ++LQ + +
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
++ R A+ + A+EAR + +++ A + Q+ S++ E A+ +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2131
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 554
AA A R+ + + +K A Q ++ + +T +
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 607
L+L++ ++N LD ELQ + E R R Q E E ++LSK+ ++E E
Sbjct: 2192 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250
Query: 608 -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 652
L+ + L + E +Q +E + +EAA LRQ +L QQ+ L +
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 653 ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 707
L+EK+ V+ TRL+ + +++ A+ + + Q+ ++ A+E +R+ E
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 708 RRLQEEARKEEGQRLARRLQELER 731
R ++ E +RL R+ E+ R
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSR 2394
Score = 112 bits (281), Expect = 1e-24
Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 204
+ LRR+EEE RL + +++ RL E Q EA A+A+ EA+ L+ +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 256
EVVR+ E + + ++ +R QE+L L Q+ E + + +AE E+S
Sbjct: 1399 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 257 ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 295
L + E +R G EL +AQ EAE LR+Q+ ++Q +A+
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 296 VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 332
V L ++ K Q E+ Q E ER Q LET Q
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574
Query: 333 ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
LQ R S L+ +Q +A EE R+ Q E + + L R
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1633
Query: 390 WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 444
W+ K AL ++L+A+E+ S+ Q + + A + + +++EQA+ QR L ++
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1692
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
E+E +R A+G + A++ R + +T E+Q +L LE +A+++
Sbjct: 1693 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1740
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
AA L + LA++R E +V L + EE
Sbjct: 1741 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1776
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
+R +E S + ++ E GR RE E E +L +A++ +++ Q +E A
Sbjct: 1777 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1825
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
+ A + L ++ G+A + K E E L+E+ ++ ER RR
Sbjct: 1826 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1871
Query: 685 KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 740
R+++ +AAQ K ER +LR+ + ELER K L+ TL
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1917
Query: 741 QQ 742
+Q
Sbjct: 1918 RQ 1919
Score = 102 bits (254), Expect = 1e-21
Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)
Query: 95 GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 154
G Q+V ER Q ERDV +R R + LE QA+ Q +V R+L++L
Sbjct: 1155 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1205
Query: 155 RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 213
R ++R RE++ + L + R E ++A LA ++ VR+ L
Sbjct: 1206 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
+ Q LEE++R H E++ + ++ ++++ L + LE A AK+ +
Sbjct: 1249 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1304
Query: 274 AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 333
Q +E + ++ + TL K++ E + + L Q+ E + L
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1362
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
E +L +L + Q+ Q E +++Q ++ E R+ ++ ++ ++K
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1415
Query: 394 VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
+Q + Q+L S + Q K + A E+ + +E+ + R LQ +A E + R
Sbjct: 1416 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1469
Query: 453 GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
GA+G LQ +RA+EA + +Q AE +LR V S + E +A A A+
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 568
R A+ ++ R+L A++ RQ L ELQ R
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 569 DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 624
A+L+ S + V + RE+ E QQ + ++ E+EL++ Q ++ +L L+L+
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
QQ+S +A + +Q+ ++E + E+ A + L EQ + +R+L E +
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1706
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
QR AA+ QEL RL+ E + E QR Q LE + LA LQ+E
Sbjct: 1707 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1743
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 803
+ K+Q L L + + + +++S E + + + E+ G L ++
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 804 --LQDLSEAISKEEAVCQGD 821
L+ L+E ++ + + D
Sbjct: 1804 ARLRALAEEAKRQRQLAEED 1823
Score = 94.4 bits (233), Expect = 4e-19
Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 211
Q R++EE RL + Q + R +AQA AEK R EAE A A AE
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2157
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
++ + E+E+ ++ ++ L Q +E L++L + E + + L+ +EL
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2209
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
+ EA +Q S+ +E+L + +E L K + + + ++ L + T +
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2264
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
LQE+ + + AE L V Q + L EE+L ++ ++ + E K Q++
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2321
Query: 389 RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 446
R K A L+ Q K E + +++ K Q+A + T Q +R Q + +AE
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 498
E ++ + +RA+E +R+++Q E+L A ++T
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 499 ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 536
+A++E +L L ++ T++ ++ K +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 537 LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 591
L Q + QE L D + QQLREE+ R ++ Q RL+ R Q E
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 592 AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
AE QQL + +Q E+ L + + L LE + +EE + +
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
T+ AL AE E E D RR A+R ++S ++Q R AQ
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2677
Query: 703 RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 743
EL R ++ +G+ +A L + +K + A LQ++
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2719
Score = 82.4 bits (202), Expect = 2e-15
Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 211
EEV E L++ + A ELEA + K RA+AE LR L GA+ V +
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 260
L++ EV+R +E+++ L + + L+ + LE+ L
Sbjct: 1162 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1220
Query: 261 ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 312
+ RR E A LA++Q E LR++ + +E +E VE +++ + + +
Sbjct: 1221 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1279
Query: 313 ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 356
E+ T++ + + + + + S E + +R ++ ++
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 357 ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 415
L EEE R + + E E + ++ L + R+ A Q KAQ E E + +++
Sbjct: 1340 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1397
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ +V +E Q++ +Q LQ E E + AK Q E + R
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1449
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE++R+V ++ LE T + GA +L +L R A
Sbjct: 1450 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1485
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+ +Q +EE RL R +Q E R R Q E E
Sbjct: 1486 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1518
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 654
K + +E Q+ ++L L LQ E A R+ +Q E A ++ L Q L
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 707
Q K A E+ + ER L E EH + +RRA Q+ +E +EL
Sbjct: 1579 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631
Query: 708 RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 743
R Q +A E RL + +E+ + K+L A +++
Sbjct: 1632 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 119 bits (297), Expect = 2e-26
Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)
Query: 142 QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 201
+QAE+ + ++L EE R E +Q+ + E +A AR KA E E L+A
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2020
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
+ A +R+ E+ S R+L+ Q Q++L + +AH A+ + + + S+
Sbjct: 2021 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080
Query: 262 TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 321
+ GEA+ A EAE R Q + QV E L++ EQ + +Q
Sbjct: 2081 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2136
Query: 322 ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 381
A AE L+ + A E+ R+ Q +D+ E E +
Sbjct: 2137 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2175
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 439
K R + +V + L+ Q LE +D K L L E++ E +A QRS
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2228
Query: 440 LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 499
+VE E + ELS+ + E L++ ++Q +L+
Sbjct: 2229 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2273
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 559
K++ A + RLS A ++ +R L LA + E + E
Sbjct: 2274 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2320
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
Q +E RL AE A L+QQ+ A+EQ ++ ++AQQL +E Q Q +
Sbjct: 2321 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2371
Query: 620 LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
LE RQ Q E + EA L+ + + QA E+ A+ + E++ + R A
Sbjct: 2372 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 738
+E V +L ++++ + ER +E + L+ E KE+ Q+ A+ LQ K+ +
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2481
Query: 739 TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
T+QQE LL + QQ L+ SLL +++ + E VA A RE +
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2541
Query: 797 LSVLLDDLQDLSEAISKEEA 816
+ + Q L S EEA
Sbjct: 2542 QQQMEQERQRL--VASMEEA 2559
Score = 114 bits (284), Expect = 5e-25
Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)
Query: 124 EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 168
E G + R E L ++A ++ QEL R E EV L R TS
Sbjct: 1727 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786
Query: 169 LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 228
+ K RLEA+A LA EA LRA A+ R+ EE + R+ E +R+
Sbjct: 1787 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1839
Query: 229 QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 283
E+L+++ T+ EA +L K E + L L A + + L E AQ +A++ +
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 284 --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 333
QL K + +LE Q LVE+ R+ V E++ S + + E + L ++
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
ED AEL R + L + E +VQ S + E E R+ ++ L
Sbjct: 1959 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2018
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 445
+ + +E +S +QL+ + Q+++ ++ Q++ LQ++LQ + +
Sbjct: 2019 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
++ R A+ + A+EAR + +++ A + Q+ S++ E A+ +
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2135
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 554
AA A R+ + + +K A Q ++ + +T +
Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2195
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 607
L+L++ ++N LD ELQ + E R R Q E E ++LSK+ ++E E
Sbjct: 2196 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2254
Query: 608 -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 652
L+ + L + E +Q +E + +EAA LRQ +L QQ+ L +
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2314
Query: 653 ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 707
L+EK+ V+ TRL+ + +++ A+ + + Q+ ++ A+E +R+ E
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 708 RRLQEEARKEEGQRLARRLQELER 731
R ++ E +RL R+ E+ R
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSR 2398
Score = 112 bits (281), Expect = 1e-24
Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 204
+ LRR+EEE RL + +++ RL E Q EA A+A+ EA+ L+ +
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 256
EVVR+ E + + ++ +R QE+L L Q+ E + + +AE E+S
Sbjct: 1403 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
Query: 257 ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 295
L + E +R G EL +AQ EAE LR+Q+ ++Q +A+
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518
Query: 296 VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 332
V L ++ K Q E+ Q E ER Q LET Q
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1578
Query: 333 ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
LQ R S L+ +Q +A EE R+ Q E + + L R
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1637
Query: 390 WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 444
W+ K AL ++L+A+E+ S+ Q + + A + + +++EQA+ QR L ++
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1696
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
E+E +R A+G + A++ R + +T E+Q +L LE +A+++
Sbjct: 1697 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1744
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
AA L + LA++R E +V L + EE
Sbjct: 1745 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1780
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
+R +E S + ++ E GR RE E E +L +A++ +++ Q +E A
Sbjct: 1781 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1829
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
+ A + L ++ G+A + K E E L+E+ ++ ER RR
Sbjct: 1830 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1875
Query: 685 KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 740
R+++ +AAQ K ER +LR+ + ELER K L+ TL
Sbjct: 1876 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1921
Query: 741 QQ 742
+Q
Sbjct: 1922 RQ 1923
Score = 102 bits (254), Expect = 1e-21
Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)
Query: 95 GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 154
G Q+V ER Q ERDV +R R + LE QA+ Q +V R+L++L
Sbjct: 1159 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1209
Query: 155 RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 213
R ++R RE++ + L + R E ++A LA ++ VR+ L
Sbjct: 1210 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1252
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
+ Q LEE++R H E++ + ++ ++++ L + LE A AK+ +
Sbjct: 1253 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1308
Query: 274 AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 333
Q +E + ++ + TL K++ E + + L Q+ E + L
Sbjct: 1309 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1366
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
E +L +L + Q+ Q E +++Q ++ E R+ ++ ++ ++K
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1419
Query: 394 VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
+Q + Q+L S + Q K + A E+ + +E+ + R LQ +A E + R
Sbjct: 1420 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1473
Query: 453 GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
GA+G LQ +RA+EA + +Q AE +LR V S + E +A A A+
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 568
R A+ ++ R+L A++ RQ L ELQ R
Sbjct: 1533 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592
Query: 569 DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 624
A+L+ S + V + RE+ E QQ + ++ E+EL++ Q ++ +L L+L+
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
QQ+S +A + +Q+ ++E + E+ A + L EQ + +R+L E +
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1710
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
QR AA+ QEL RL+ E + E QR Q LE + LA LQ+E
Sbjct: 1711 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1747
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 803
+ K+Q L L + + + +++S E + + + E+ G L ++
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 804 --LQDLSEAISKEEAVCQGD 821
L+ L+E ++ + + D
Sbjct: 1808 ARLRALAEEAKRQRQLAEED 1827
Score = 94.4 bits (233), Expect = 4e-19
Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 211
Q R++EE RL + Q + R +AQA AEK R EAE A A AE
Sbjct: 2110 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2161
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
++ + E+E+ ++ ++ L Q +E L++L + E + + L+ +EL
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2213
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
+ EA +Q S+ +E+L + +E L K + + + ++ L + T +
Sbjct: 2214 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2268
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
LQE+ + + AE L V Q + L EE+L ++ ++ + E K Q++
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2325
Query: 389 RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 446
R K A L+ Q K E + +++ K Q+A + T Q +R Q + +AE
Sbjct: 2326 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2385
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 498
E ++ + +RA+E +R+++Q E+L A ++T
Sbjct: 2386 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445
Query: 499 ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 536
+A++E +L L ++ T++ ++ K +
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2505
Query: 537 LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 591
L Q + QE L D + QQLREE+ R ++ Q RL+ R Q E
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565
Query: 592 AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
AE QQL + +Q E+ L + + L LE + +EE + +
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2625
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
T+ AL AE E E D RR A+R ++S ++Q R AQ
Sbjct: 2626 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2681
Query: 703 RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 743
EL R ++ +G+ +A L + +K + A LQ++
Sbjct: 2682 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2723
Score = 82.4 bits (202), Expect = 2e-15
Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 211
EEV E L++ + A ELEA + K RA+AE LR L GA+ V +
Sbjct: 1106 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1165
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 260
L++ EV+R +E+++ L + + L+ + LE+ L
Sbjct: 1166 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1224
Query: 261 ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 312
+ RR E A LA++Q E LR++ + +E +E VE +++ + + +
Sbjct: 1225 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1283
Query: 313 ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 356
E+ T++ + + + + + S E + +R ++ ++
Sbjct: 1284 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1343
Query: 357 ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 415
L EEE R + + E E + ++ L + R+ A Q KAQ E E + +++
Sbjct: 1344 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1401
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ +V +E Q++ +Q LQ E E + AK Q E + R
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1453
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE++R+V ++ LE T + GA +L +L R A
Sbjct: 1454 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1489
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+ +Q +EE RL R +Q E R R Q E E
Sbjct: 1490 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1522
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 654
K + +E Q+ ++L L LQ E A R+ +Q E A ++ L Q L
Sbjct: 1523 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1582
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 707
Q K A E+ + ER L E EH + +RRA Q+ +E +EL
Sbjct: 1583 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1635
Query: 708 RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 743
R Q +A E RL + +E+ + K+L A +++
Sbjct: 1636 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1669
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 119 bits (297), Expect = 2e-26
Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)
Query: 142 QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 201
+QAE+ + ++L EE R E +Q+ + E +A AR KA E E L+A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2016
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
+ A +R+ E+ S R+L+ Q Q++L + +AH A+ + + + S+
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076
Query: 262 TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 321
+ GEA+ A EAE R Q + QV E L++ EQ + +Q
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2132
Query: 322 ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 381
A AE L+ + A E+ R+ Q +D+ E E +
Sbjct: 2133 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2171
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 439
K R + +V + L+ Q LE +D K L L E++ E +A QRS
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2224
Query: 440 LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 499
+VE E + ELS+ + E L++ ++Q +L+
Sbjct: 2225 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2269
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 559
K++ A + RLS A ++ +R L LA + E + E
Sbjct: 2270 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2316
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
Q +E RL AE A L+QQ+ A+EQ ++ ++AQQL +E Q Q +
Sbjct: 2317 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2367
Query: 620 LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
LE RQ Q E + EA L+ + + QA E+ A+ + E++ + R A
Sbjct: 2368 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 738
+E V +L ++++ + ER +E + L+ E KE+ Q+ A+ LQ K+ +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2477
Query: 739 TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
T+QQE LL + QQ L+ SLL +++ + E VA A RE +
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2537
Query: 797 LSVLLDDLQDLSEAISKEEA 816
+ + Q L S EEA
Sbjct: 2538 QQQMEQERQRL--VASMEEA 2555
Score = 114 bits (284), Expect = 5e-25
Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)
Query: 124 EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 168
E G + R E L ++A ++ QEL R E EV L R TS
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782
Query: 169 LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 228
+ K RLEA+A LA EA LRA A+ R+ EE + R+ E +R+
Sbjct: 1783 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835
Query: 229 QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 283
E+L+++ T+ EA +L K E + L L A + + L E AQ +A++ +
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 284 --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 333
QL K + +LE Q LVE+ R+ V E++ S + + E + L ++
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
ED AEL R + L + E +VQ S + E E R+ ++ L
Sbjct: 1955 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 445
+ + +E +S +QL+ + Q+++ ++ Q++ LQ++LQ + +
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
++ R A+ + A+EAR + +++ A + Q+ S++ E A+ +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2131
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 554
AA A R+ + + +K A Q ++ + +T +
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 607
L+L++ ++N LD ELQ + E R R Q E E ++LSK+ ++E E
Sbjct: 2192 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250
Query: 608 -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 652
L+ + L + E +Q +E + +EAA LRQ +L QQ+ L +
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 653 ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 707
L+EK+ V+ TRL+ + +++ A+ + + Q+ ++ A+E +R+ E
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 708 RRLQEEARKEEGQRLARRLQELER 731
R ++ E +RL R+ E+ R
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSR 2394
Score = 112 bits (281), Expect = 1e-24
Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 204
+ LRR+EEE RL + +++ RL E Q EA A+A+ EA+ L+ +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 256
EVVR+ E + + ++ +R QE+L L Q+ E + + +AE E+S
Sbjct: 1399 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 257 ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 295
L + E +R G EL +AQ EAE LR+Q+ ++Q +A+
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 296 VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 332
V L ++ K Q E+ Q E ER Q LET Q
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1574
Query: 333 ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
LQ R S L+ +Q +A EE R+ Q E + + L R
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1633
Query: 390 WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 444
W+ K AL ++L+A+E+ S+ Q + + A + + +++EQA+ QR L ++
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1692
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
E+E +R A+G + A++ R + +T E+Q +L LE +A+++
Sbjct: 1693 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1740
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
AA L + LA++R E +V L + EE
Sbjct: 1741 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1776
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
+R +E S + ++ E GR RE E E +L +A++ +++ Q +E A
Sbjct: 1777 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1825
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
+ A + L ++ G+A + K E E L+E+ ++ ER RR
Sbjct: 1826 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1871
Query: 685 KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 740
R+++ +AAQ K ER +LR+ + ELER K L+ TL
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1917
Query: 741 QQ 742
+Q
Sbjct: 1918 RQ 1919
Score = 102 bits (254), Expect = 1e-21
Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)
Query: 95 GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 154
G Q+V ER Q ERDV +R R + LE QA+ Q +V R+L++L
Sbjct: 1155 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1205
Query: 155 RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 213
R ++R RE++ + L + R E ++A LA ++ VR+ L
Sbjct: 1206 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1248
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
+ Q LEE++R H E++ + ++ ++++ L + LE A AK+ +
Sbjct: 1249 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1304
Query: 274 AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 333
Q +E + ++ + TL K++ E + + L Q+ E + L
Sbjct: 1305 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1362
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
E +L +L + Q+ Q E +++Q ++ E R+ ++ ++ ++K
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1415
Query: 394 VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
+Q + Q+L S + Q K + A E+ + +E+ + R LQ +A E + R
Sbjct: 1416 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1469
Query: 453 GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
GA+G LQ +RA+EA + +Q AE +LR V S + E +A A A+
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 568
R A+ ++ R+L A++ RQ L ELQ R
Sbjct: 1529 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 569 DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 624
A+L+ S + V + RE+ E QQ + ++ E+EL++ Q ++ +L L+L+
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
QQ+S +A + +Q+ ++E + E+ A + L EQ + +R+L E +
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1706
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
QR AA+ QEL RL+ E + E QR Q LE + LA LQ+E
Sbjct: 1707 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1743
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 803
+ K+Q L L + + + +++S E + + + E+ G L ++
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 804 --LQDLSEAISKEEAVCQGD 821
L+ L+E ++ + + D
Sbjct: 1804 ARLRALAEEAKRQRQLAEED 1823
Score = 94.4 bits (233), Expect = 4e-19
Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 211
Q R++EE RL + Q + R +AQA AEK R EAE A A AE
Sbjct: 2106 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2157
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
++ + E+E+ ++ ++ L Q +E L++L + E + + L+ +EL
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2209
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
+ EA +Q S+ +E+L + +E L K + + + ++ L + T +
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2264
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
LQE+ + + AE L V Q + L EE+L ++ ++ + E K Q++
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2321
Query: 389 RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 446
R K A L+ Q K E + +++ K Q+A + T Q +R Q + +AE
Sbjct: 2322 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2381
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 498
E ++ + +RA+E +R+++Q E+L A ++T
Sbjct: 2382 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 499 ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 536
+A++E +L L ++ T++ ++ K +
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 537 LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 591
L Q + QE L D + QQLREE+ R ++ Q RL+ R Q E
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 592 AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
AE QQL + +Q E+ L + + L LE + +EE + +
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2621
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
T+ AL AE E E D RR A+R ++S ++Q R AQ
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2677
Query: 703 RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 743
EL R ++ +G+ +A L + +K + A LQ++
Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2719
Score = 82.4 bits (202), Expect = 2e-15
Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 211
EEV E L++ + A ELEA + K RA+AE LR L GA+ V +
Sbjct: 1102 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1161
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 260
L++ EV+R +E+++ L + + L+ + LE+ L
Sbjct: 1162 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1220
Query: 261 ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 312
+ RR E A LA++Q E LR++ + +E +E VE +++ + + +
Sbjct: 1221 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1279
Query: 313 ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 356
E+ T++ + + + + + S E + +R ++ ++
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 357 ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 415
L EEE R + + E E + ++ L + R+ A Q KAQ E E + +++
Sbjct: 1340 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1397
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ +V +E Q++ +Q LQ E E + AK Q E + R
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1449
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE++R+V ++ LE T + GA +L +L R A
Sbjct: 1450 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1485
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+ +Q +EE RL R +Q E R R Q E E
Sbjct: 1486 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1518
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 654
K + +E Q+ ++L L LQ E A R+ +Q E A ++ L Q L
Sbjct: 1519 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1578
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 707
Q K A E+ + ER L E EH + +RRA Q+ +E +EL
Sbjct: 1579 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631
Query: 708 RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 743
R Q +A E RL + +E+ + K+L A +++
Sbjct: 1632 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 119 bits (297), Expect = 2e-26
Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)
Query: 142 QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 201
+QAE+ + ++L EE R E +Q+ + E +A AR KA E E L+A
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 1984
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
+ A +R+ E+ S R+L+ Q Q++L + +AH A+ + + + S+
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044
Query: 262 TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 321
+ GEA+ A EAE R Q + QV E L++ EQ + +Q
Sbjct: 2045 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2100
Query: 322 ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 381
A AE L+ + A E+ R+ Q +D+ E E +
Sbjct: 2101 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2139
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 439
K R + +V + L+ Q LE +D K L L E++ E +A QRS
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2192
Query: 440 LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 499
+VE E + ELS+ + E L++ ++Q +L+
Sbjct: 2193 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2237
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 559
K++ A + RLS A ++ +R L LA + E + E
Sbjct: 2238 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2284
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
Q +E RL AE A L+QQ+ A+EQ ++ ++AQQL +E Q Q +
Sbjct: 2285 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2335
Query: 620 LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
LE RQ Q E + EA L+ + + QA E+ A+ + E++ + R A
Sbjct: 2336 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2391
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 738
+E V +L ++++ + ER +E + L+ E KE+ Q+ A+ LQ K+ +
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2445
Query: 739 TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
T+QQE LL + QQ L+ SLL +++ + E VA A RE +
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2505
Query: 797 LSVLLDDLQDLSEAISKEEA 816
+ + Q L S EEA
Sbjct: 2506 QQQMEQERQRL--VASMEEA 2523
Score = 114 bits (284), Expect = 5e-25
Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)
Query: 124 EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 168
E G + R E L ++A ++ QEL R E EV L R TS
Sbjct: 1691 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750
Query: 169 LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 228
+ K RLEA+A LA EA LRA A+ R+ EE + R+ E +R+
Sbjct: 1751 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803
Query: 229 QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 283
E+L+++ T+ EA +L K E + L L A + + L E AQ +A++ +
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 284 --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 333
QL K + +LE Q LVE+ R+ V E++ S + + E + L ++
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
ED AEL R + L + E +VQ S + E E R+ ++ L
Sbjct: 1923 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1982
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 445
+ + +E +S +QL+ + Q+++ ++ Q++ LQ++LQ + +
Sbjct: 1983 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
++ R A+ + A+EAR + +++ A + Q+ S++ E A+ +
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2099
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 554
AA A R+ + + +K A Q ++ + +T +
Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2159
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 607
L+L++ ++N LD ELQ + E R R Q E E ++LSK+ ++E E
Sbjct: 2160 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2218
Query: 608 -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 652
L+ + L + E +Q +E + +EAA LRQ +L QQ+ L +
Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2278
Query: 653 ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 707
L+EK+ V+ TRL+ + +++ A+ + + Q+ ++ A+E +R+ E
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 708 RRLQEEARKEEGQRLARRLQELER 731
R ++ E +RL R+ E+ R
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSR 2362
Score = 112 bits (281), Expect = 1e-24
Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 204
+ LRR+EEE RL + +++ RL E Q EA A+A+ EA+ L+ +
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 256
EVVR+ E + + ++ +R QE+L L Q+ E + + +AE E+S
Sbjct: 1367 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422
Query: 257 ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 295
L + E +R G EL +AQ EAE LR+Q+ ++Q +A+
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482
Query: 296 VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 332
V L ++ K Q E+ Q E ER Q LET Q
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1542
Query: 333 ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
LQ R S L+ +Q +A EE R+ Q E + + L R
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1601
Query: 390 WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 444
W+ K AL ++L+A+E+ S+ Q + + A + + +++EQA+ QR L ++
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1660
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
E+E +R A+G + A++ R + +T E+Q +L LE +A+++
Sbjct: 1661 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1708
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
AA L + LA++R E +V L + EE
Sbjct: 1709 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1744
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
+R +E S + ++ E GR RE E E +L +A++ +++ Q +E A
Sbjct: 1745 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1793
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
+ A + L ++ G+A + K E E L+E+ ++ ER RR
Sbjct: 1794 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1839
Query: 685 KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 740
R+++ +AAQ K ER +LR+ + ELER K L+ TL
Sbjct: 1840 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1885
Query: 741 QQ 742
+Q
Sbjct: 1886 RQ 1887
Score = 102 bits (254), Expect = 1e-21
Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)
Query: 95 GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 154
G Q+V ER Q ERDV +R R + LE QA+ Q +V R+L++L
Sbjct: 1123 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1173
Query: 155 RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 213
R ++R RE++ + L + R E ++A LA ++ VR+ L
Sbjct: 1174 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1216
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
+ Q LEE++R H E++ + ++ ++++ L + LE A AK+ +
Sbjct: 1217 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1272
Query: 274 AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 333
Q +E + ++ + TL K++ E + + L Q+ E + L
Sbjct: 1273 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1330
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
E +L +L + Q+ Q E +++Q ++ E R+ ++ ++ ++K
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1383
Query: 394 VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
+Q + Q+L S + Q K + A E+ + +E+ + R LQ +A E + R
Sbjct: 1384 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1437
Query: 453 GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
GA+G LQ +RA+EA + +Q AE +LR V S + E +A A A+
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 568
R A+ ++ R+L A++ RQ L ELQ R
Sbjct: 1497 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556
Query: 569 DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 624
A+L+ S + V + RE+ E QQ + ++ E+EL++ Q ++ +L L+L+
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
QQ+S +A + +Q+ ++E + E+ A + L EQ + +R+L E +
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1674
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
QR AA+ QEL RL+ E + E QR Q LE + LA LQ+E
Sbjct: 1675 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1711
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 803
+ K+Q L L + + + +++S E + + + E+ G L ++
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 804 --LQDLSEAISKEEAVCQGD 821
L+ L+E ++ + + D
Sbjct: 1772 ARLRALAEEAKRQRQLAEED 1791
Score = 94.4 bits (233), Expect = 4e-19
Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 211
Q R++EE RL + Q + R +AQA AEK R EAE A A AE
Sbjct: 2074 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2125
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
++ + E+E+ ++ ++ L Q +E L++L + E + + L+ +EL
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2177
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
+ EA +Q S+ +E+L + +E L K + + + ++ L + T +
Sbjct: 2178 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2232
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
LQE+ + + AE L V Q + L EE+L ++ ++ + E K Q++
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2289
Query: 389 RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 446
R K A L+ Q K E + +++ K Q+A + T Q +R Q + +AE
Sbjct: 2290 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2349
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 498
E ++ + +RA+E +R+++Q E+L A ++T
Sbjct: 2350 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409
Query: 499 ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 536
+A++E +L L ++ T++ ++ K +
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2469
Query: 537 LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 591
L Q + QE L D + QQLREE+ R ++ Q RL+ R Q E
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2529
Query: 592 AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
AE QQL + +Q E+ L + + L LE + +EE + +
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2589
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
T+ AL AE E E D RR A+R ++S ++Q R AQ
Sbjct: 2590 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2645
Query: 703 RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 743
EL R ++ +G+ +A L + +K + A LQ++
Sbjct: 2646 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2687
Score = 82.4 bits (202), Expect = 2e-15
Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 211
EEV E L++ + A ELEA + K RA+AE LR L GA+ V +
Sbjct: 1070 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1129
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 260
L++ EV+R +E+++ L + + L+ + LE+ L
Sbjct: 1130 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1188
Query: 261 ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 312
+ RR E A LA++Q E LR++ + +E +E VE +++ + + +
Sbjct: 1189 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1247
Query: 313 ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 356
E+ T++ + + + + + S E + +R ++ ++
Sbjct: 1248 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1307
Query: 357 ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 415
L EEE R + + E E + ++ L + R+ A Q KAQ E E + +++
Sbjct: 1308 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1365
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ +V +E Q++ +Q LQ E E + AK Q E + R
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1417
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE++R+V ++ LE T + GA +L +L R A
Sbjct: 1418 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1453
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+ +Q +EE RL R +Q E R R Q E E
Sbjct: 1454 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1486
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 654
K + +E Q+ ++L L LQ E A R+ +Q E A ++ L Q L
Sbjct: 1487 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1546
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 707
Q K A E+ + ER L E EH + +RRA Q+ +E +EL
Sbjct: 1547 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1599
Query: 708 RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 743
R Q +A E RL + +E+ + K+L A +++
Sbjct: 1600 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1633
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 119 bits (297), Expect = 2e-26
Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)
Query: 142 QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 201
+QAE+ + ++L EE R E +Q+ + E +A AR KA E E L+A
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2153
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
+ A +R+ E+ S R+L+ Q Q++L + +AH A+ + + + S+
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213
Query: 262 TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 321
+ GEA+ A EAE R Q + QV E L++ EQ + +Q
Sbjct: 2214 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2269
Query: 322 ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 381
A AE L+ + A E+ R+ Q +D+ E E +
Sbjct: 2270 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2308
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 439
K R + +V + L+ Q LE +D K L L E++ E +A QRS
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2361
Query: 440 LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 499
+VE E + ELS+ + E L++ ++Q +L+
Sbjct: 2362 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2406
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 559
K++ A + RLS A ++ +R L LA + E + E
Sbjct: 2407 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2453
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
Q +E RL AE A L+QQ+ A+EQ ++ ++AQQL +E Q Q +
Sbjct: 2454 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2504
Query: 620 LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
LE RQ Q E + EA L+ + + QA E+ A+ + E++ + R A
Sbjct: 2505 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2560
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 738
+E V +L ++++ + ER +E + L+ E KE+ Q+ A+ LQ K+ +
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2614
Query: 739 TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
T+QQE LL + QQ L+ SLL +++ + E VA A RE +
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2674
Query: 797 LSVLLDDLQDLSEAISKEEA 816
+ + Q L S EEA
Sbjct: 2675 QQQMEQERQRL--VASMEEA 2692
Score = 114 bits (284), Expect = 5e-25
Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)
Query: 124 EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 168
E G + R E L ++A ++ QEL R E EV L R TS
Sbjct: 1860 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919
Query: 169 LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 228
+ K RLEA+A LA EA LRA A+ R+ EE + R+ E +R+
Sbjct: 1920 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1972
Query: 229 QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 283
E+L+++ T+ EA +L K E + L L A + + L E AQ +A++ +
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 284 --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 333
QL K + +LE Q LVE+ R+ V E++ S + + E + L ++
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
ED AEL R + L + E +VQ S + E E R+ ++ L
Sbjct: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 445
+ + +E +S +QL+ + Q+++ ++ Q++ LQ++LQ + +
Sbjct: 2152 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
++ R A+ + A+EAR + +++ A + Q+ S++ E A+ +
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2268
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 554
AA A R+ + + +K A Q ++ + +T +
Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2328
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 607
L+L++ ++N LD ELQ + E R R Q E E ++LSK+ ++E E
Sbjct: 2329 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2387
Query: 608 -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 652
L+ + L + E +Q +E + +EAA LRQ +L QQ+ L +
Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2447
Query: 653 ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 707
L+EK+ V+ TRL+ + +++ A+ + + Q+ ++ A+E +R+ E
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 708 RRLQEEARKEEGQRLARRLQELER 731
R ++ E +RL R+ E+ R
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSR 2531
Score = 112 bits (281), Expect = 1e-24
Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 204
+ LRR+EEE RL + +++ RL E Q EA A+A+ EA+ L+ +
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 256
EVVR+ E + + ++ +R QE+L L Q+ E + + +AE E+S
Sbjct: 1536 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591
Query: 257 ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 295
L + E +R G EL +AQ EAE LR+Q+ ++Q +A+
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651
Query: 296 VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 332
V L ++ K Q E+ Q E ER Q LET Q
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1711
Query: 333 ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
LQ R S L+ +Q +A EE R+ Q E + + L R
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1770
Query: 390 WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 444
W+ K AL ++L+A+E+ S+ Q + + A + + +++EQA+ QR L ++
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1829
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
E+E +R A+G + A++ R + +T E+Q +L LE +A+++
Sbjct: 1830 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1877
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
AA L + LA++R E +V L + EE
Sbjct: 1878 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1913
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
+R +E S + ++ E GR RE E E +L +A++ +++ Q +E A
Sbjct: 1914 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1962
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
+ A + L ++ G+A + K E E L+E+ ++ ER RR
Sbjct: 1963 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 2008
Query: 685 KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 740
R+++ +AAQ K ER +LR+ + ELER K L+ TL
Sbjct: 2009 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 2054
Query: 741 QQ 742
+Q
Sbjct: 2055 RQ 2056
Score = 102 bits (254), Expect = 1e-21
Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)
Query: 95 GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 154
G Q+V ER Q ERDV +R R + LE QA+ Q +V R+L++L
Sbjct: 1292 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1342
Query: 155 RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 213
R ++R RE++ + L + R E ++A LA ++ VR+ L
Sbjct: 1343 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1385
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
+ Q LEE++R H E++ + ++ ++++ L + LE A AK+ +
Sbjct: 1386 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1441
Query: 274 AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 333
Q +E + ++ + TL K++ E + + L Q+ E + L
Sbjct: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1499
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
E +L +L + Q+ Q E +++Q ++ E R+ ++ ++ ++K
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1552
Query: 394 VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
+Q + Q+L S + Q K + A E+ + +E+ + R LQ +A E + R
Sbjct: 1553 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1606
Query: 453 GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
GA+G LQ +RA+EA + +Q AE +LR V S + E +A A A+
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 568
R A+ ++ R+L A++ RQ L ELQ R
Sbjct: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725
Query: 569 DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 624
A+L+ S + V + RE+ E QQ + ++ E+EL++ Q ++ +L L+L+
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
QQ+S +A + +Q+ ++E + E+ A + L EQ + +R+L E +
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1843
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
QR AA+ QEL RL+ E + E QR Q LE + LA LQ+E
Sbjct: 1844 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1880
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 803
+ K+Q L L + + + +++S E + + + E+ G L ++
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 804 --LQDLSEAISKEEAVCQGD 821
L+ L+E ++ + + D
Sbjct: 1941 ARLRALAEEAKRQRQLAEED 1960
Score = 94.4 bits (233), Expect = 4e-19
Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 211
Q R++EE RL + Q + R +AQA AEK R EAE A A AE
Sbjct: 2243 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2294
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
++ + E+E+ ++ ++ L Q +E L++L + E + + L+ +EL
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2346
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
+ EA +Q S+ +E+L + +E L K + + + ++ L + T +
Sbjct: 2347 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2401
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
LQE+ + + AE L V Q + L EE+L ++ ++ + E K Q++
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2458
Query: 389 RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 446
R K A L+ Q K E + +++ K Q+A + T Q +R Q + +AE
Sbjct: 2459 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2518
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 498
E ++ + +RA+E +R+++Q E+L A ++T
Sbjct: 2519 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578
Query: 499 ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 536
+A++E +L L ++ T++ ++ K +
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2638
Query: 537 LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 591
L Q + QE L D + QQLREE+ R ++ Q RL+ R Q E
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698
Query: 592 AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
AE QQL + +Q E+ L + + L LE + +EE + +
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
T+ AL AE E E D RR A+R ++S ++Q R AQ
Sbjct: 2759 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2814
Query: 703 RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 743
EL R ++ +G+ +A L + +K + A LQ++
Sbjct: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2856
Score = 82.4 bits (202), Expect = 2e-15
Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 211
EEV E L++ + A ELEA + K RA+AE LR L GA+ V +
Sbjct: 1239 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1298
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 260
L++ EV+R +E+++ L + + L+ + LE+ L
Sbjct: 1299 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1357
Query: 261 ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 312
+ RR E A LA++Q E LR++ + +E +E VE +++ + + +
Sbjct: 1358 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1416
Query: 313 ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 356
E+ T++ + + + + + S E + +R ++ ++
Sbjct: 1417 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1476
Query: 357 ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 415
L EEE R + + E E + ++ L + R+ A Q KAQ E E + +++
Sbjct: 1477 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1534
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ +V +E Q++ +Q LQ E E + AK Q E + R
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1586
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE++R+V ++ LE T + GA +L +L R A
Sbjct: 1587 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1622
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+ +Q +EE RL R +Q E R R Q E E
Sbjct: 1623 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1655
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 654
K + +E Q+ ++L L LQ E A R+ +Q E A ++ L Q L
Sbjct: 1656 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1715
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 707
Q K A E+ + ER L E EH + +RRA Q+ +E +EL
Sbjct: 1716 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1768
Query: 708 RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 743
R Q +A E RL + +E+ + K+L A +++
Sbjct: 1769 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1802
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 119 bits (297), Expect = 2e-26
Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)
Query: 142 QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 201
+QAE+ + ++L EE R E +Q+ + E +A AR KA E E L+A
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 1994
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
+ A +R+ E+ S R+L+ Q Q++L + +AH A+ + + + S+
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054
Query: 262 TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 321
+ GEA+ A EAE R Q + QV E L++ EQ + +Q
Sbjct: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2110
Query: 322 ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 381
A AE L+ + A E+ R+ Q +D+ E E +
Sbjct: 2111 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2149
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 439
K R + +V + L+ Q LE +D K L L E++ E +A QRS
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2202
Query: 440 LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 499
+VE E + ELS+ + E L++ ++Q +L+
Sbjct: 2203 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2247
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 559
K++ A + RLS A ++ +R L LA + E + E
Sbjct: 2248 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2294
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
Q +E RL AE A L+QQ+ A+EQ ++ ++AQQL +E Q Q +
Sbjct: 2295 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2345
Query: 620 LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
LE RQ Q E + EA L+ + + QA E+ A+ + E++ + R A
Sbjct: 2346 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2401
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 738
+E V +L ++++ + ER +E + L+ E KE+ Q+ A+ LQ K+ +
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2455
Query: 739 TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
T+QQE LL + QQ L+ SLL +++ + E VA A RE +
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2515
Query: 797 LSVLLDDLQDLSEAISKEEA 816
+ + Q L S EEA
Sbjct: 2516 QQQMEQERQRL--VASMEEA 2533
Score = 114 bits (284), Expect = 5e-25
Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)
Query: 124 EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 168
E G + R E L ++A ++ QEL R E EV L R TS
Sbjct: 1701 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760
Query: 169 LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 228
+ K RLEA+A LA EA LRA A+ R+ EE + R+ E +R+
Sbjct: 1761 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1813
Query: 229 QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 283
E+L+++ T+ EA +L K E + L L A + + L E AQ +A++ +
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 284 --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 333
QL K + +LE Q LVE+ R+ V E++ S + + E + L ++
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
ED AEL R + L + E +VQ S + E E R+ ++ L
Sbjct: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 445
+ + +E +S +QL+ + Q+++ ++ Q++ LQ++LQ + +
Sbjct: 1993 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
++ R A+ + A+EAR + +++ A + Q+ S++ E A+ +
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2109
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 554
AA A R+ + + +K A Q ++ + +T +
Sbjct: 2110 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2169
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 607
L+L++ ++N LD ELQ + E R R Q E E ++LSK+ ++E E
Sbjct: 2170 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2228
Query: 608 -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 652
L+ + L + E +Q +E + +EAA LRQ +L QQ+ L +
Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2288
Query: 653 ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 707
L+EK+ V+ TRL+ + +++ A+ + + Q+ ++ A+E +R+ E
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 708 RRLQEEARKEEGQRLARRLQELER 731
R ++ E +RL R+ E+ R
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSR 2372
Score = 112 bits (281), Expect = 1e-24
Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 204
+ LRR+EEE RL + +++ RL E Q EA A+A+ EA+ L+ +
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 256
EVVR+ E + + ++ +R QE+L L Q+ E + + +AE E+S
Sbjct: 1377 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432
Query: 257 ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 295
L + E +R G EL +AQ EAE LR+Q+ ++Q +A+
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492
Query: 296 VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 332
V L ++ K Q E+ Q E ER Q LET Q
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1552
Query: 333 ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
LQ R S L+ +Q +A EE R+ Q E + + L R
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1611
Query: 390 WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 444
W+ K AL ++L+A+E+ S+ Q + + A + + +++EQA+ QR L ++
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1670
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
E+E +R A+G + A++ R + +T E+Q +L LE +A+++
Sbjct: 1671 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1718
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
AA L + LA++R E +V L + EE
Sbjct: 1719 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1754
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
+R +E S + ++ E GR RE E E +L +A++ +++ Q +E A
Sbjct: 1755 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1803
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
+ A + L ++ G+A + K E E L+E+ ++ ER RR
Sbjct: 1804 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1849
Query: 685 KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 740
R+++ +AAQ K ER +LR+ + ELER K L+ TL
Sbjct: 1850 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1895
Query: 741 QQ 742
+Q
Sbjct: 1896 RQ 1897
Score = 102 bits (254), Expect = 1e-21
Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)
Query: 95 GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 154
G Q+V ER Q ERDV +R R + LE QA+ Q +V R+L++L
Sbjct: 1133 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1183
Query: 155 RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 213
R ++R RE++ + L + R E ++A LA ++ VR+ L
Sbjct: 1184 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1226
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
+ Q LEE++R H E++ + ++ ++++ L + LE A AK+ +
Sbjct: 1227 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1282
Query: 274 AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 333
Q +E + ++ + TL K++ E + + L Q+ E + L
Sbjct: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1340
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
E +L +L + Q+ Q E +++Q ++ E R+ ++ ++ ++K
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1393
Query: 394 VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
+Q + Q+L S + Q K + A E+ + +E+ + R LQ +A E + R
Sbjct: 1394 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1447
Query: 453 GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
GA+G LQ +RA+EA + +Q AE +LR V S + E +A A A+
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 568
R A+ ++ R+L A++ RQ L ELQ R
Sbjct: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566
Query: 569 DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 624
A+L+ S + V + RE+ E QQ + ++ E+EL++ Q ++ +L L+L+
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
QQ+S +A + +Q+ ++E + E+ A + L EQ + +R+L E +
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1684
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
QR AA+ QEL RL+ E + E QR Q LE + LA LQ+E
Sbjct: 1685 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1721
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 803
+ K+Q L L + + + +++S E + + + E+ G L ++
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 804 --LQDLSEAISKEEAVCQGD 821
L+ L+E ++ + + D
Sbjct: 1782 ARLRALAEEAKRQRQLAEED 1801
Score = 94.4 bits (233), Expect = 4e-19
Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 211
Q R++EE RL + Q + R +AQA AEK R EAE A A AE
Sbjct: 2084 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2135
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
++ + E+E+ ++ ++ L Q +E L++L + E + + L+ +EL
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2187
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
+ EA +Q S+ +E+L + +E L K + + + ++ L + T +
Sbjct: 2188 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2242
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
LQE+ + + AE L V Q + L EE+L ++ ++ + E K Q++
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2299
Query: 389 RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 446
R K A L+ Q K E + +++ K Q+A + T Q +R Q + +AE
Sbjct: 2300 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2359
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 498
E ++ + +RA+E +R+++Q E+L A ++T
Sbjct: 2360 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419
Query: 499 ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 536
+A++E +L L ++ T++ ++ K +
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2479
Query: 537 LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 591
L Q + QE L D + QQLREE+ R ++ Q RL+ R Q E
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539
Query: 592 AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
AE QQL + +Q E+ L + + L LE + +EE + +
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
T+ AL AE E E D RR A+R ++S ++Q R AQ
Sbjct: 2600 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2655
Query: 703 RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 743
EL R ++ +G+ +A L + +K + A LQ++
Sbjct: 2656 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2697
Score = 82.4 bits (202), Expect = 2e-15
Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 211
EEV E L++ + A ELEA + K RA+AE LR L GA+ V +
Sbjct: 1080 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1139
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 260
L++ EV+R +E+++ L + + L+ + LE+ L
Sbjct: 1140 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1198
Query: 261 ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 312
+ RR E A LA++Q E LR++ + +E +E VE +++ + + +
Sbjct: 1199 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1257
Query: 313 ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 356
E+ T++ + + + + + S E + +R ++ ++
Sbjct: 1258 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1317
Query: 357 ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 415
L EEE R + + E E + ++ L + R+ A Q KAQ E E + +++
Sbjct: 1318 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1375
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ +V +E Q++ +Q LQ E E + AK Q E + R
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1427
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE++R+V ++ LE T + GA +L +L R A
Sbjct: 1428 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1463
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+ +Q +EE RL R +Q E R R Q E E
Sbjct: 1464 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1496
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 654
K + +E Q+ ++L L LQ E A R+ +Q E A ++ L Q L
Sbjct: 1497 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1556
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 707
Q K A E+ + ER L E EH + +RRA Q+ +E +EL
Sbjct: 1557 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1609
Query: 708 RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 743
R Q +A E RL + +E+ + K+L A +++
Sbjct: 1610 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1643
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 119 bits (297), Expect = 2e-26
Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)
Query: 142 QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 201
+QAE+ + ++L EE R E +Q+ + E +A AR KA E E L+A
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2002
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
+ A +R+ E+ S R+L+ Q Q++L + +AH A+ + + + S+
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062
Query: 262 TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 321
+ GEA+ A EAE R Q + QV E L++ EQ + +Q
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2118
Query: 322 ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 381
A AE L+ + A E+ R+ Q +D+ E E +
Sbjct: 2119 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2157
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 439
K R + +V + L+ Q LE +D K L L E++ E +A QRS
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2210
Query: 440 LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 499
+VE E + ELS+ + E L++ ++Q +L+
Sbjct: 2211 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2255
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 559
K++ A + RLS A ++ +R L LA + E + E
Sbjct: 2256 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2302
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
Q +E RL AE A L+QQ+ A+EQ ++ ++AQQL +E Q Q +
Sbjct: 2303 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2353
Query: 620 LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
LE RQ Q E + EA L+ + + QA E+ A+ + E++ + R A
Sbjct: 2354 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2409
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 738
+E V +L ++++ + ER +E + L+ E KE+ Q+ A+ LQ K+ +
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2463
Query: 739 TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
T+QQE LL + QQ L+ SLL +++ + E VA A RE +
Sbjct: 2464 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2523
Query: 797 LSVLLDDLQDLSEAISKEEA 816
+ + Q L S EEA
Sbjct: 2524 QQQMEQERQRL--VASMEEA 2541
Score = 114 bits (284), Expect = 5e-25
Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)
Query: 124 EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 168
E G + R E L ++A ++ QEL R E EV L R TS
Sbjct: 1709 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1768
Query: 169 LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 228
+ K RLEA+A LA EA LRA A+ R+ EE + R+ E +R+
Sbjct: 1769 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1821
Query: 229 QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 283
E+L+++ T+ EA +L K E + L L A + + L E AQ +A++ +
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 284 --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 333
QL K + +LE Q LVE+ R+ V E++ S + + E + L ++
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
ED AEL R + L + E +VQ S + E E R+ ++ L
Sbjct: 1941 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2000
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 445
+ + +E +S +QL+ + Q+++ ++ Q++ LQ++LQ + +
Sbjct: 2001 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
++ R A+ + A+EAR + +++ A + Q+ S++ E A+ +
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2117
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 554
AA A R+ + + +K A Q ++ + +T +
Sbjct: 2118 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2177
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 607
L+L++ ++N LD ELQ + E R R Q E E ++LSK+ ++E E
Sbjct: 2178 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2236
Query: 608 -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 652
L+ + L + E +Q +E + +EAA LRQ +L QQ+ L +
Sbjct: 2237 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2296
Query: 653 ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 707
L+EK+ V+ TRL+ + +++ A+ + + Q+ ++ A+E +R+ E
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 708 RRLQEEARKEEGQRLARRLQELER 731
R ++ E +RL R+ E+ R
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSR 2380
Score = 112 bits (281), Expect = 1e-24
Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 204
+ LRR+EEE RL + +++ RL E Q EA A+A+ EA+ L+ +
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 256
EVVR+ E + + ++ +R QE+L L Q+ E + + +AE E+S
Sbjct: 1385 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440
Query: 257 ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 295
L + E +R G EL +AQ EAE LR+Q+ ++Q +A+
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500
Query: 296 VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 332
V L ++ K Q E+ Q E ER Q LET Q
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1560
Query: 333 ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
LQ R S L+ +Q +A EE R+ Q E + + L R
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1619
Query: 390 WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 444
W+ K AL ++L+A+E+ S+ Q + + A + + +++EQA+ QR L ++
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1678
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
E+E +R A+G + A++ R + +T E+Q +L LE +A+++
Sbjct: 1679 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1726
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
AA L + LA++R E +V L + EE
Sbjct: 1727 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1762
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
+R +E S + ++ E GR RE E E +L +A++ +++ Q +E A
Sbjct: 1763 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1811
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
+ A + L ++ G+A + K E E L+E+ ++ ER RR
Sbjct: 1812 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1857
Query: 685 KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 740
R+++ +AAQ K ER +LR+ + ELER K L+ TL
Sbjct: 1858 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1903
Query: 741 QQ 742
+Q
Sbjct: 1904 RQ 1905
Score = 102 bits (254), Expect = 1e-21
Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)
Query: 95 GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 154
G Q+V ER Q ERDV +R R + LE QA+ Q +V R+L++L
Sbjct: 1141 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1191
Query: 155 RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 213
R ++R RE++ + L + R E ++A LA ++ VR+ L
Sbjct: 1192 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1234
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
+ Q LEE++R H E++ + ++ ++++ L + LE A AK+ +
Sbjct: 1235 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1290
Query: 274 AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 333
Q +E + ++ + TL K++ E + + L Q+ E + L
Sbjct: 1291 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1348
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
E +L +L + Q+ Q E +++Q ++ E R+ ++ ++ ++K
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1401
Query: 394 VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
+Q + Q+L S + Q K + A E+ + +E+ + R LQ +A E + R
Sbjct: 1402 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1455
Query: 453 GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
GA+G LQ +RA+EA + +Q AE +LR V S + E +A A A+
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 568
R A+ ++ R+L A++ RQ L ELQ R
Sbjct: 1515 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574
Query: 569 DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 624
A+L+ S + V + RE+ E QQ + ++ E+EL++ Q ++ +L L+L+
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
QQ+S +A + +Q+ ++E + E+ A + L EQ + +R+L E +
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1692
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
QR AA+ QEL RL+ E + E QR Q LE + LA LQ+E
Sbjct: 1693 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1729
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 803
+ K+Q L L + + + +++S E + + + E+ G L ++
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 804 --LQDLSEAISKEEAVCQGD 821
L+ L+E ++ + + D
Sbjct: 1790 ARLRALAEEAKRQRQLAEED 1809
Score = 94.4 bits (233), Expect = 4e-19
Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 211
Q R++EE RL + Q + R +AQA AEK R EAE A A AE
Sbjct: 2092 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2143
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
++ + E+E+ ++ ++ L Q +E L++L + E + + L+ +EL
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2195
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
+ EA +Q S+ +E+L + +E L K + + + ++ L + T +
Sbjct: 2196 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2250
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
LQE+ + + AE L V Q + L EE+L ++ ++ + E K Q++
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2307
Query: 389 RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 446
R K A L+ Q K E + +++ K Q+A + T Q +R Q + +AE
Sbjct: 2308 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2367
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 498
E ++ + +RA+E +R+++Q E+L A ++T
Sbjct: 2368 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2427
Query: 499 ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 536
+A++E +L L ++ T++ ++ K +
Sbjct: 2428 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2487
Query: 537 LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 591
L Q + QE L D + QQLREE+ R ++ Q RL+ R Q E
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2547
Query: 592 AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
AE QQL + +Q E+ L + + L LE + +EE + +
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2607
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
T+ AL AE E E D RR A+R ++S ++Q R AQ
Sbjct: 2608 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2663
Query: 703 RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 743
EL R ++ +G+ +A L + +K + A LQ++
Sbjct: 2664 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2705
Score = 82.4 bits (202), Expect = 2e-15
Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 211
EEV E L++ + A ELEA + K RA+AE LR L GA+ V +
Sbjct: 1088 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1147
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 260
L++ EV+R +E+++ L + + L+ + LE+ L
Sbjct: 1148 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1206
Query: 261 ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 312
+ RR E A LA++Q E LR++ + +E +E VE +++ + + +
Sbjct: 1207 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1265
Query: 313 ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 356
E+ T++ + + + + + S E + +R ++ ++
Sbjct: 1266 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1325
Query: 357 ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 415
L EEE R + + E E + ++ L + R+ A Q KAQ E E + +++
Sbjct: 1326 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1383
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ +V +E Q++ +Q LQ E E + AK Q E + R
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1435
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE++R+V ++ LE T + GA +L +L R A
Sbjct: 1436 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1471
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+ +Q +EE RL R +Q E R R Q E E
Sbjct: 1472 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1504
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 654
K + +E Q+ ++L L LQ E A R+ +Q E A ++ L Q L
Sbjct: 1505 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1564
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 707
Q K A E+ + ER L E EH + +RRA Q+ +E +EL
Sbjct: 1565 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1617
Query: 708 RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 743
R Q +A E RL + +E+ + K+L A +++
Sbjct: 1618 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1651
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 119 bits (297), Expect = 2e-26
Identities = 173/680 (25%), Positives = 283/680 (41%), Gaps = 92/680 (13%)
Query: 142 QQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRA 201
+QAE+ + ++L EE R E +Q+ + E +A AR KA E E L+A
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA------ARQRKAALEEVERLKA 2043
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
+ A +R+ E+ S R+L+ Q Q++L + +AH A+ + + + S+
Sbjct: 2044 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103
Query: 262 TRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWEL 321
+ GEA+ A EAE R Q + QV E L++ EQ + +Q
Sbjct: 2104 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ---- 2159
Query: 322 ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTR 381
A AE L+ + A E+ R+ Q +D+ E E +
Sbjct: 2160 --------------------AAAEKLRKEAEQEAARRAQAEQAALRQKQAADA-EMEKHK 2198
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE--QAILQRS 439
K R + +V + L+ Q LE +D K L L E++ E +A QRS
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQ-LEETDHQKNL------LDEELQRLKAEATEAARQRS 2251
Query: 440 LQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETT 499
+VE E + ELS+ + E L++ ++Q +L+
Sbjct: 2252 ------QVEEELFSVRVQMEELSKL---------KARIEAENRALILRDKDNTQRFLQEE 2296
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQ 559
K++ A + RLS A ++ +R L LA + E + E
Sbjct: 2297 AEKMKQVAEEAA----RLSVAAQEAARLRQLAEEDLAQQRALAEK---------MLKEKM 2343
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
Q +E RL AE A L+QQ+ A+EQ ++ ++AQQL +E Q Q +
Sbjct: 2344 QAVQEATRLKAE----AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT----- 2394
Query: 620 LQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
LE RQ Q E + EA L+ + + QA E+ A+ + E++ + R A
Sbjct: 2395 --LEAERQRQLEMSAEAERLKLRVAEMSR--AQARAEEDAQRFRKQAEEIGEKLHRTELA 2450
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQE-LRRLQEEARKEEGQRLARRLQELERDKNLMLA 738
+E V +L ++++ + ER +E + L+ E KE+ Q+ A+ LQ K+ +
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELERE--KEKLQQEAKLLQL----KSEEMQ 2504
Query: 739 TLQQEGLLSRYK--QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
T+QQE LL + QQ L+ SLL +++ + E VA A RE +
Sbjct: 2505 TVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ 2564
Query: 797 LSVLLDDLQDLSEAISKEEA 816
+ + Q L S EEA
Sbjct: 2565 QQQMEQERQRL--VASMEEA 2582
Score = 114 bits (284), Expect = 5e-25
Identities = 166/684 (24%), Positives = 295/684 (43%), Gaps = 88/684 (12%)
Query: 124 EPGRRGRSWGLEGSQALSQQAEVIVRQLQELR------RLEEEVRLL---------RETS 168
E G + R E L ++A ++ QEL R E EV L R TS
Sbjct: 1750 EQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1809
Query: 169 LQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLH 228
+ K RLEA+A LA EA LRA A+ R+ EE + R+ E +R+
Sbjct: 1810 EKSKQRLEAEAGRFRELAE-------EAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1862
Query: 229 QEQLSSL---TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE--AQREAELLRK 283
E+L+++ T+ EA +L K E + L L A + + L E AQ +A++ +
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEK-EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 284 --QLSKTQE-DLEAQVTLVENL---RKYVGEQV----PSEVHSQTWELERQKLLETMQHL 333
QL K + +LE Q LVE+ R+ V E++ S + + E + L ++
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
ED AEL R + L + E +VQ S + E E R+ ++ L
Sbjct: 1982 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2041
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ--------SQEQAILQRSLQDKAA 445
+ + +E +S +QL+ + Q+++ ++ Q++ LQ++LQ + +
Sbjct: 2042 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Query: 446 EVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEG 505
++ R A+ + A+EAR + +++ A + Q+ S++ E A+ +
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE---EQAQARAQA 2158
Query: 506 AAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----------LAQLRQESCPLPPPVTDV 554
AA A R+ + + +K A Q ++ + +T +
Sbjct: 2159 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2218
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE-------RQQLSKVAQQLEQE 607
L+L++ ++N LD ELQ + E R R Q E E ++LSK+ ++E E
Sbjct: 2219 RLQLEETDHQKNLLDEELQ-RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2277
Query: 608 -----LQQTQESLASLGLQLEVARQGQQE------STEEAASLRQ----ELTQQQELYGQ 652
L+ + L + E +Q +E + +EAA LRQ +L QQ+ L +
Sbjct: 2278 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2337
Query: 653 ALQEKVAEVE--TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK---ERSQEL 707
L+EK+ V+ TRL+ + +++ A+ + + Q+ ++ A+E +R+ E
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 708 RRLQEEARKEEGQRLARRLQELER 731
R ++ E +RL R+ E+ R
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSR 2421
Score = 112 bits (281), Expect = 1e-24
Identities = 166/662 (25%), Positives = 275/662 (41%), Gaps = 152/662 (22%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRL-------EAQAMELEALARAEKAGRAEAEGLRAALA 204
+ LRR+EEE RL + +++ RL E Q EA A+A+ EA+ L+ +
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS-------- 256
EVVR+ E + + ++ +R QE+L L Q+ E + + +AE E+S
Sbjct: 1426 -EEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481
Query: 257 ------LSSLETRRAGEAKELA--------------EAQREAELLRKQLS-KTQEDLEAQ 295
L + E +R G EL +AQ EAE LR+Q+ ++Q +A+
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541
Query: 296 VTLVENLR--------KYVGEQVPSEVHSQTWELER-------------QKLLETMQH-- 332
V L ++ K Q E+ Q E ER Q LET Q
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSA 1601
Query: 333 ---LQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
LQ R S L+ +Q +A EE R+ Q E + + L R
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELER 1660
Query: 390 WREKVF-ALMVQLKAQELEHSDSVKQLKGQV----ASLQEKVTSQSQEQAILQRSLQDKA 444
W+ K AL ++L+A+E+ S+ Q + + A + + +++EQA+ QR L ++
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ- 1719
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
E+E +R A+G + A++ R + +T E+Q +L LE +A+++
Sbjct: 1720 -ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL-----------LEEELARLQ 1767
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
AA L + LA++R E +V L + EE
Sbjct: 1768 REAAAATQKRQEL----------------EAELAKVRAEM--------EVLLASKARAEE 1803
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
+R +E S + ++ E GR RE E E +L +A++ +++ Q +E A
Sbjct: 1804 ESRSTSEK--SKQRLEAEAGRFRELAE-EAARLRALAEEAKRQRQLAEEDAA-------- 1852
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
+ A + L ++ G+A + K E E L+E+ ++ ER RR
Sbjct: 1853 ---------RQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENER----LRRLAE 1898
Query: 685 KAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATL 740
R+++ +AAQ K ER +LR+ + ELER K L+ TL
Sbjct: 1899 DEAFQRRRLEEQAAQHKADIEERLAQLRKASD--------------SELERQKGLVEDTL 1944
Query: 741 QQ 742
+Q
Sbjct: 1945 RQ 1946
Score = 102 bits (254), Expect = 1e-21
Identities = 178/740 (24%), Positives = 321/740 (43%), Gaps = 84/740 (11%)
Query: 95 GHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQEL 154
G Q+V ER Q ERDV +R R + LE QA+ Q +V R+L++L
Sbjct: 1182 GAQEVGERL------QQRHGERDVEVERW---RERVAQLLERWQAVLAQTDVRQRELEQL 1232
Query: 155 RRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA-LAGAEVVRKNL 213
R ++R RE++ + L + R E ++A LA ++ VR+ L
Sbjct: 1233 GR---QLRYYRESA--------------DPLGAWLQDARRRQEQIQAMPLADSQAVREQL 1275
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
+ Q LEE++R H E++ + ++ ++++ L + LE A AK+ +
Sbjct: 1276 RQ-EQALLEEIER-HGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV-ASPAKK-PK 1331
Query: 274 AQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHL 333
Q +E + ++ + TL K++ E + + L Q+ E + L
Sbjct: 1332 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEE--RLAEQQRAEERERL 1389
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
E +L +L + Q+ Q E +++Q ++ E R+ ++ ++ ++K
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKA-----QAEREAKELQ--QRMQEEVVRREEAAVDAQQQK 1442
Query: 394 VFALMVQLKAQELEHSDSVK-QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
+Q + Q+L S + Q K + A E+ + +E+ + R LQ +A E + R
Sbjct: 1443 ---RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR-LQLEATERQ--RG 1496
Query: 453 GAKG-LQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
GA+G LQ +RA+EA + +Q AE +LR V S + E +A A A+
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAE-RLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQL---RQESCPLPPPVTDVSLELQQLREERNRL 568
R A+ ++ R+L A++ RQ L ELQ R
Sbjct: 1556 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615
Query: 569 DAELQLSARLIQQEVGRAREQGEAERQQ---LSKVAQQLEQELQQTQ-ESLASLGLQLEV 624
A+L+ S + V + RE+ E QQ + ++ E+EL++ Q ++ +L L+L+
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
Query: 625 ARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHA 684
QQ+S +A + +Q+ ++E + E+ A + L EQ + +R+L E +
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ-- 1733
Query: 685 KAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEG 744
QR AA+ QEL RL+ E + E QR Q LE + LA LQ+E
Sbjct: 1734 ---------QRLAAE-----QELIRLRAETEQGEQQR-----QLLEEE----LARLQREA 1770
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDD- 803
+ K+Q L L + + + +++S E + + + E+ G L ++
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 804 --LQDLSEAISKEEAVCQGD 821
L+ L+E ++ + + D
Sbjct: 1831 ARLRALAEEAKRQRQLAEED 1850
Score = 94.4 bits (233), Expect = 4e-19
Identities = 150/642 (23%), Positives = 262/642 (40%), Gaps = 78/642 (12%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRK 211
Q R++EE RL + Q + R +AQA AEK R EAE A A AE
Sbjct: 2133 QSRRQVEEAERLKQSAEEQAQARAQAQAA-------AEKL-RKEAEQEAARRAQAEQAAL 2184
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
++ + E+E+ ++ ++ L Q +E L++L + E + + L+ +EL
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLD-------EEL 2236
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
+ EA +Q S+ +E+L + +E L K + + + ++ L + T +
Sbjct: 2237 QRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAENRALILRDKDNTQR 2291
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
LQE+ + + AE L V Q + L EE+L ++ ++ + E K Q++
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE---KMQAVQE 2348
Query: 389 RWREKVFA-LMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQ-DKAAE 446
R K A L+ Q K E + +++ K Q+A + T Q +R Q + +AE
Sbjct: 2349 ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE 2408
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLET-------- 498
E ++ + +RA+E +R+++Q E+L A ++T
Sbjct: 2409 AERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2468
Query: 499 ---------TMAKVEGAAAQLPSLNNRLSYAVRKVHTIR-------------GLIARKLA 536
+A++E +L L ++ T++ ++ K +
Sbjct: 2469 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2528
Query: 537 LAQ----LRQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGE 591
L Q + QE L D + QQLREE+ R ++ Q RL+ R Q E
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588
Query: 592 AER---------QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
AE QQL + +Q E+ L + + L LE + +EE + +
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2648
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
T+ AL AE E E D RR A+R ++S ++Q R AQ
Sbjct: 2649 ATKTLPNGRDALDGPAAEAEP---EHSFDGLRRKVSAQRLQEAGILSAEELQ-RLAQGHT 2704
Query: 703 RSQELRRLQEEARKEEGQ-RLARRLQELERDKNLMLATLQQE 743
EL R ++ +G+ +A L + +K + A LQ++
Sbjct: 2705 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQ 2746
Score = 82.4 bits (202), Expect = 2e-15
Identities = 148/636 (23%), Positives = 251/636 (39%), Gaps = 123/636 (19%)
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG-------LRAALAGAEVVRK 211
EEV E L++ + A ELEA + K RA+AE LR L GA+ V +
Sbjct: 1129 EEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE 1188
Query: 212 NLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSL----------- 260
L++ EV+R +E+++ L + + L+ + LE+ L
Sbjct: 1189 RLQQRHGERDVEVERW-RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1247
Query: 261 ----ETRRAGE---AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPS- 312
+ RR E A LA++Q E LR++ + +E +E VE +++ + + +
Sbjct: 1248 AWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAI 1306
Query: 313 ---EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVR-------------VQSLTH 356
E+ T++ + + + + + S E + +R ++ ++
Sbjct: 1307 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1366
Query: 357 ILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ-ELEHSDSVKQL 415
L EEE R + + E E + ++ L + R+ A Q KAQ E E + +++
Sbjct: 1367 TLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRM 1424
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ +V +E Q++ +Q LQ E E + AK Q E + R
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSRLR------- 1476
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE++R+V ++ LE T + GA +L +L R A
Sbjct: 1477 --IEEEIRVV-------RLQLEATERQRGGAEGELQALRARAEEA--------------- 1512
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+ +Q +EE RL R +Q E R R Q E E
Sbjct: 1513 -------------------EAQKRQAQEEAERL-------RRQVQDESQRKR-QAEVELA 1545
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVA-RQGQQESTEEAASLRQELTQQQELYGQAL 654
K + +E Q+ ++L L LQ E A R+ +Q E A ++ L Q L
Sbjct: 1546 SRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAEL 1605
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE-------KERSQEL 707
Q K A E+ + ER L E EH + +RRA Q+ +E +EL
Sbjct: 1606 QSKRAS----FAEKTAQLERSLQE---EHVAVAQLREEAERRAQQQAEAERAREEAEREL 1658
Query: 708 RRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE 743
R Q +A E RL + +E+ + K+L A +++
Sbjct: 1659 ERWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQ 1692
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 118 bits (296), Expect = 2e-26
Identities = 201/776 (25%), Positives = 322/776 (41%), Gaps = 124/776 (15%)
Query: 133 GLEGSQALSQQA-EVIVRQLQELR----RLEEEVRLL------RETSLQQKMR-LEAQAM 180
GLEGS +++QA E + +QL LR +L+E++ L RE L+Q R + Q
Sbjct: 803 GLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862
Query: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQR----------ELEEVQR---- 226
LE AR ++A E GL L AE + L E + R L EVQR
Sbjct: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ 922
Query: 227 --LHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE----AKELAEAQREAEL 280
+EQL + QA A +LT + GL + + + + + + + A++L +A+REA+
Sbjct: 923 LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQA 982
Query: 281 -LRKQLSKTQEDL-------EAQVTLVENLRKYVGEQVPSEVHS--QTWELERQKLLETM 330
LR+Q + +EDL EA +E R + Q+ E E E+++L E +
Sbjct: 983 SLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEI 1042
Query: 331 QHLQEDRDS--LHATAELLQVRVQSLTHILALQEEEL-TRKVQPSDSLEPEFTRK-CQSL 386
LQ++RD L A +E Q + AL E+ + TR + SLE E ++ QS
Sbjct: 1043 AALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSR 1102
Query: 387 LNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAE 446
+ R V AL +L+ + ++ +V LQE+ +++ R ++ +
Sbjct: 1103 QEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQ 1162
Query: 447 VEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGA 506
+ + GL+ EL AQ R Q+ ++ E + EGA
Sbjct: 1163 LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAG-------------ELRRSLGEGA 1209
Query: 507 AAQ--LPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE 564
+ L N L AV+K + R I+ KLA Q+ L T V E +LR
Sbjct: 1210 KEREALRRSNEELRSAVKKAESER--ISLKLANEDKEQKLALLEEARTAVGKEAGELRTG 1267
Query: 565 RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEV 624
QEV R+R + E Q+L + + L+ E + LA L +L +
Sbjct: 1268 L---------------QEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312
Query: 625 ARQGQQESTEEAASLRQEL----------TQQQELYGQALQEKVAEVETRLREQLSDTE- 673
+ ++ES E LRQ L Q+ ++ + LQE+ E TR R L E
Sbjct: 1313 GERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEE 1372
Query: 674 -RRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERD 732
R + + +HA+ + +++ AA+ + LR E R Q L L +E
Sbjct: 1373 ARGTEKQQLDHARGL----ELKLEAARAEAAELGLRLSAAEGR---AQGLEAELARVEVQ 1425
Query: 733 KNLMLATLQQEGLLSRYKQQRLLTVLPSLLDK--------------KKSVVSSPRPPECS 778
+ A Q GL S ++ L PS + ++SP ECS
Sbjct: 1426 RR--AAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECS 1483
Query: 779 AS----APVAAAVPTR-----ESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLDR 825
+P A P E+++G+L L +L+ S ++E Q L+R
Sbjct: 1484 PGSQPPSPGPATSPASPDLDPEAVRGALREFLQELR--SAQRERDELRTQTSALNR 1537
Score = 113 bits (283), Expect = 6e-25
Identities = 171/661 (25%), Positives = 291/661 (44%), Gaps = 83/661 (12%)
Query: 179 AMELEALARAEKAGRAEAEG-----LRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLS 233
A+ L + GR EA LR L+ +E R+ LEE ++QRL +++
Sbjct: 527 ALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEE-------QLQRL-RDKTD 578
Query: 234 SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE 293
QAHE+A + + L + L ++ A L AQ++AE LR++ K Q
Sbjct: 579 GAMQAHEDA----QREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQA--- 631
Query: 294 AQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQS 353
AQ E LR+ E E++ ++ ++ + + H E L+ +
Sbjct: 632 AQ----EELRR----------QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSV 677
Query: 354 LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK 413
L L E L+R D L+ E + +V + + +A +E S+
Sbjct: 678 LAKELVEVREALSRATLQRDMLQAE------------KAEVAEALTKAEAGRVELELSMT 725
Query: 414 QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ 473
+L+ + ASLQ+ ++ S A+ + QDK +++ R+ A+ L+ E S Q +R+ +Q
Sbjct: 726 KLRAEEASLQDSLSKLS---ALNESLAQDK---LDLNRLVAQ-LEEEKSALQGRQRQAEQ 778
Query: 474 Q-TASAEEQLRLVVNAVSS--SQIWLETTMAKVEGAAA----QLPSLNNRLSYAVRKVHT 526
+ T + EEQ RL + ++ LE ++ E A QLP+L + S ++
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838
Query: 527 I-RGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAEL---QLSARLIQQE 582
+ R L R+ L Q R+E+ + + E + L +E L +L + R + +E
Sbjct: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 583 VGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
R R + EA L +V +QL Q L+ +E L + G L +A++ T E A LRQ+
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQ-LEARREQLEAEGQALLLAKE---TLTGELAGLRQQ 954
Query: 643 LTQQQE-------LYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR 695
+ QE L Q L + E + LREQ + E L +RE A L +
Sbjct: 955 IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014
Query: 696 RAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLL 755
+ + +R QE + EA KEE LQ+ ERD+ L+LA +++ LS K+
Sbjct: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQ-ERDEGLLLAESEKQQALS-LKESEKT 1072
Query: 756 TVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 815
+ L+ + S+ + E A +E + +++ L +L+DL +EE
Sbjct: 1073 ALSEKLMGTRHSLATISLEME----RQKRDAQSRQEQDRSTVNALTSELRDL--RAQREE 1126
Query: 816 A 816
A
Sbjct: 1127 A 1127
Score = 102 bits (254), Expect = 1e-21
Identities = 172/625 (27%), Positives = 264/625 (42%), Gaps = 87/625 (13%)
Query: 153 ELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKN 212
E R LEE+++ LR+ + E E++ L A + E L +L A+ +
Sbjct: 562 ERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE 621
Query: 213 LEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS---LSSLETRRAGEAK 269
L + + +L+ Q + Q L + E+A+ LE+S L LE +R+ AK
Sbjct: 622 LRQ-EREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680
Query: 270 ELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLET 329
EL E REA L R L + E + + E L K +E EL KL
Sbjct: 681 ELVEV-REA-LSRATLQRDMLQAE-KAEVAEALTK-------AEAGRVELELSMTKLRAE 730
Query: 330 MQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT--RKCQSLL 387
LQ+ L A E L L ++A EEE + E E T R+ Q L
Sbjct: 731 EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERL 790
Query: 388 NRWR-EKVFA-------LMVQLKAQE--------LEHSDSVKQLKGQVASLQEKVTSQSQ 431
R E+ A L V +AQE L H S QL+ Q+A L +++ + Q
Sbjct: 791 EELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERS--QLQEQLAQLSRQLSGREQ 848
Query: 432 EQAILQR-------SLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRL 484
E +R +L+ A E E GL ++L A+ R ++ +LRL
Sbjct: 849 ELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT----RLRL 904
Query: 485 VVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQES 544
A+ S ++ +A++E QL + L A T+ G +A QE
Sbjct: 905 EKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLA---KETLTGELAGLRQQIIATQEK 961
Query: 545 CPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQL 604
L D L Q+L + A L+ ++++ R + + EA ++L QL
Sbjct: 962 ASL-----DKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL 1016
Query: 605 EQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE----LTQQQELYGQALQEKVAE 660
+ +LQ+ QE L + +LE + +E +EE A+L+QE L + QAL K +E
Sbjct: 1017 QSQLQREQEELLA---RLEAEK---EELSEEIAALQQERDEGLLLAESEKQQALSLKESE 1070
Query: 661 VETRLREQLSDTERRLNEARREHAKAVVSLR-QIQRRAA---QEKERS---------QEL 707
+T L E+L T H+ A +SL + Q+R A QE++RS ++L
Sbjct: 1071 -KTALSEKLMGT---------RHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL 1120
Query: 708 RRLQEEARKEEGQRLARRLQELERD 732
R +EEA Q + RRLQE RD
Sbjct: 1121 RAQREEAAAAHAQEV-RRLQEQARD 1144
Score = 88.2 bits (217), Expect = 3e-17
Identities = 144/577 (24%), Positives = 233/577 (40%), Gaps = 106/577 (18%)
Query: 151 LQELRRLEEEVRLLR-ETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA------L 203
LQELR + E LR +TS + E +A A +RA + +A AE A L
Sbjct: 1515 LQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574
Query: 204 AGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETR 263
+G + L+E S R E +R +Q+++L ++ + S L + E + K + + ET+
Sbjct: 1575 SGVQA-ELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISK-MKANETK 1632
Query: 264 RAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELER 323
G+ + L E +E +L + LE GE S + E +
Sbjct: 1633 LEGDKRRLKEVLDASESRTVKLELQRRSLE-------------GELQRSRLGLSDREAQA 1679
Query: 324 QKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEE---LTRKVQPSDSLEPEFT 380
Q L + + LQ A LQ+ V+ L LA EE L KV+ E
Sbjct: 1680 QALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLT----EAL 1735
Query: 381 RKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSL 440
+ + LN R+K L L A E + ++L +L E QS ++L
Sbjct: 1736 AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSE-ARKQSSSLGEQVQTL 1794
Query: 441 QDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTM 500
+ + A++E++R+ A+G +L + +E R+ Q
Sbjct: 1795 RGEVADLELQRVEAEG---QLQQLREVLRQRQ---------------------------- 1823
Query: 501 AKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL-----ALAQLRQESCPLPPPVTDVS 555
EG AA L + V+K+ R L+ +L ALAQL E
Sbjct: 1824 ---EGEAAALNT--------VQKLQDERRLLQERLGSLQRALAQLEAEKR---------E 1863
Query: 556 LELQQLREERNRLDAELQLSARLIQQEVGRAREQG---EAERQQLSKVAQQLEQELQQTQ 612
+E LR E++R+ L+ + +++E R+ E AE+ +L + E EL + Q
Sbjct: 1864 VERSALRLEKDRV--ALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQ 1921
Query: 613 ESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDT 672
+ L Q+ V Q + E + +Q+L QQE+ RLR + T
Sbjct: 1922 RQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV-------------ERLRSAQAQT 1968
Query: 673 ERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRR 709
ER L R H + V L ++ + + + QELRR
Sbjct: 1969 ERTLEARERAHRQRVRGLE--EQVSTLKGQLQQELRR 2003
Score = 82.4 bits (202), Expect = 2e-15
Identities = 163/687 (23%), Positives = 263/687 (38%), Gaps = 104/687 (15%)
Query: 108 RPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQ----QAEVIVRQLQELRRLEEEVRL 163
R Q E D+ ++E R E +Q SQ Q E++ R E L EE+
Sbjct: 985 REQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAA 1044
Query: 164 LRETSLQQKMRLEAQAMELEALARAEKAGRAEA-EGLRAALAGAEV-------------- 208
L++ + + E++ + +L +EK +E G R +LA +
Sbjct: 1045 LQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQE 1104
Query: 209 ---------------VRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 253
+R EE + +EV+RL QEQ L + + L +AE L
Sbjct: 1105 QDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL-QEQARDLGKQRDSCLR----EAEEL 1159
Query: 254 EKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 313
L LE R G +EL EAQR+ L ++QE E Q LR+ +GE
Sbjct: 1160 RTQLRLLEDARDGLRRELLEAQRK-------LRESQEGREVQRQEAGELRRSLGEGAK-- 1210
Query: 314 VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSD 373
ER+ L + + L+ + L++ + LAL EE T + +
Sbjct: 1211 --------EREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG 1262
Query: 374 SLEPEFTRKCQSLLNRWRE--KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQ 431
L +S L RE ++ M L ++ + +L+G++A L E+ +S+
Sbjct: 1263 ELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA-LGERAEKESR 1321
Query: 432 EQAI-LQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVS 490
+ + L++ L A +EV R + Q +L + R +++ + E+ R
Sbjct: 1322 RETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381
Query: 491 SSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPP 550
LE K+E A A+ L RLS A + +GL A
Sbjct: 1382 DHARGLEL---KLEAARAEAAELGLRLSAAEGRA---QGLEA------------------ 1417
Query: 551 VTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQ 610
EL ++ +R +A+L +++ +G R A R A+ E
Sbjct: 1418 ------ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAE--G 1469
Query: 611 TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVET------R 664
+ E L S LE + Q S A S + + G AL+E + E+ +
Sbjct: 1470 SGEGLNSPST-LECSPGSQPPSPGPATSPASPDLDPEAVRG-ALREFLQELRSAQRERDE 1527
Query: 665 LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLAR 724
LR Q S R+L E E A RQ+Q+ A+ S+E RR + LA
Sbjct: 1528 LRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE----SEEARRSVDGRLSGVQAELAL 1583
Query: 725 RLQELERDKNLMLATLQQEGLLSRYKQ 751
+ + + R + ATL Q L R Q
Sbjct: 1584 QEESVRRSERERRATLDQVATLERSLQ 1610
Score = 79.3 bits (194), Expect = 1e-14
Identities = 153/676 (22%), Positives = 273/676 (40%), Gaps = 111/676 (16%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRL-LRETSLQQKM------RLEAQAMELEALA- 186
E A+ ++A + LQE+ R E R L+E Q KM RL + EL+
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 187 ---RAEKAGRAEAEGLRAAL----AGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAH 239
RAEK R E GLR L A EV+R+ L+ +QR+L+E + + + L +
Sbjct: 1312 LGERAEKESRRETLGLRQRLLKGEASLEVMRQELQV-AQRKLQEQEGEFRTRERRLLGSL 1370
Query: 240 EEALSSLTSK---AEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQV 296
EEA + + A GLE L + A L+ A+ A+ L +L++ + A
Sbjct: 1371 EEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAE 1430
Query: 297 TLVENLRKYV---------------------GEQVPSEVHSQTWELERQKLLETMQHLQE 335
+ LR + P+E + L LE Q
Sbjct: 1431 AQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEG--LNSPSTLECSPGSQP 1488
Query: 336 DRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREK 393
+ + +++ L +EL + D L + + + L + R+
Sbjct: 1489 PSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDS 1548
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQ--------------EQAILQRS 439
+ QL+ E ++ + + G+++ +Q ++ Q + + A L+RS
Sbjct: 1549 ATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERS 1608
Query: 440 LQD-----KAAEVEVERMGAKGLQLE--LSRAQEARRRWQQQTASAEEQLRLVVNAVSSS 492
LQ +A++ ++ +M A +LE R +E + +T E Q R + + S
Sbjct: 1609 LQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRS 1668
Query: 493 QIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR-KLALAQLRQESCPLPPPV 551
++ L A+ + ++ SL +++ + K T++ + R ALA++ + L V
Sbjct: 1669 RLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKV 1728
Query: 552 TDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQT 611
R +A Q SA L + L K E + Q
Sbjct: 1729 -------------RGLTEALAQSSASL---------NSTRDKNLHLQKALTACEHDRQVL 1766
Query: 612 QESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE---Q 668
QE +L+ ARQ E+ ++++SL +++ Q L+ +VA++E + E Q
Sbjct: 1767 QE-------RLDAARQALSEARKQSSSLGEQV--------QTLRGEVADLELQRVEAEGQ 1811
Query: 669 LSDTERRLNEARREHAKAVVSLRQIQ--RRAAQEKERSQELRRLQEEARKEEGQRLARRL 726
L L + + A A+ +++++Q RR QE+ S + Q EA K E +R A R
Sbjct: 1812 LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALR- 1870
Query: 727 QELERDKNLMLATLQQ 742
LE+D+ + TL +
Sbjct: 1871 --LEKDRVALRRTLDK 1884
Score = 78.2 bits (191), Expect = 3e-14
Identities = 159/760 (20%), Positives = 302/760 (39%), Gaps = 114/760 (15%)
Query: 134 LEGSQALSQQAEVIVRQLQELRR-LEEE---------------------VRLLRETSLQQ 171
LE + +Q+ +VRQ ELRR L+EE V+ L+ LQ
Sbjct: 124 LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY 183
Query: 172 KMRLEAQAMELEALARAEKAGRAEAEGLRAA--LAGAEVVRKNLEEGSQR--ELEEVQRL 227
K R +L E++G E + LR E LEE QR L +V +
Sbjct: 184 KKRCSELEQQL-----LERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAM 238
Query: 228 HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSK 287
+EQL A++ + + LE R A +RE E S
Sbjct: 239 LREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAA-------WRREEESFNAYFSN 291
Query: 288 TQEDLEAQVTLVENLRKYVGE----------QVPSEVHSQTWELERQKL-LETMQHLQED 336
L V R+ V E Q+ E+ + ++ L L T L E
Sbjct: 292 EHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAES 351
Query: 337 R-DSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVF 395
R ++ LLQ +++ L+E++L ++ SD + + + + L
Sbjct: 352 RAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTEL--------G 403
Query: 396 ALMVQLKAQELEHSDSVKQLKGQVAS-----LQEKVTSQSQEQAILQRSLQDKA------ 444
+ +L+ Q LE K L ++ + LQE+ ++++ LQ++L+D A
Sbjct: 404 LAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSD 463
Query: 445 AEVEVERMGA-----------KGLQLELSRAQEAR---------RRWQQQTASAEEQLRL 484
+E V+ G+ +GL + + + R RR S L L
Sbjct: 464 SESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLAL 523
Query: 485 VVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQES 544
+ +A+ Q+ ++ + E + L +L +LS + + + + R LR ++
Sbjct: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQR------LRDKT 577
Query: 545 CPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQ------QEVGRAREQGEAERQQLS 598
D E+Q+LR L E A +Q +E+ + RE+ +A +++L
Sbjct: 578 DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELR 637
Query: 599 KVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKV 658
+ +LE+E + + A + +LE + + ++ + + L +EL + +E +A ++
Sbjct: 638 RQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQR- 696
Query: 659 AEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEE 718
L+ + ++ L +A + +S+ +++ A ++ +L L E +++
Sbjct: 697 ----DMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDK 752
Query: 719 GQRLARRLQELERDKNLMLA---TLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPP 775
L R + +LE +K+ + +QE ++R +Q+RL + ++ + S R
Sbjct: 753 -LDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVA 811
Query: 776 ECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 815
E A + +PT ++ S L + L LS +S E
Sbjct: 812 E-QAQEALEQQLPT---LRHERSQLQEQLAQLSRQLSGRE 847
Score = 58.2 bits (139), Expect = 3e-08
Identities = 130/521 (24%), Positives = 214/521 (41%), Gaps = 74/521 (14%)
Query: 203 LAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKA-EGLEKSLSSLE 261
LA A+ V LE Q LE ++ L + A + ++SL + E + ++LS E
Sbjct: 5 LARAQEVELTLETVIQT-LESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPE 63
Query: 262 TR---RAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQT 318
+ A E L Q E +LL+++LS+ EDL AQ + E + SE Q
Sbjct: 64 SPVLLPATEMASLLSLQEENQLLQQELSRV-EDLLAQ-SRAERDELAIKYNAVSERLEQA 121
Query: 319 WELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELT--RKVQP---SD 373
LE +L QE R + + EL + LQEE+ + RK+Q
Sbjct: 122 LRLEPGEL-----ETQEPRGLVRQSVELRR----------QLQEEQASYRRKLQAYQEGQ 166
Query: 374 SLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQ 433
+ + ++ Q + +++++ L QL LE S ++Q + L++ SQ E
Sbjct: 167 QRQAQLVQRLQGKILQYKKRCSELEQQL----LERSGELEQQR-----LRDTEHSQDLES 217
Query: 434 AI--LQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSS 491
A+ L+ Q A+ +V M L+ +L +A A + + E +R V N +
Sbjct: 218 ALIRLEEEQQRSASLAQVNAM----LREQLDQAGSANQ-------ALSEDIRKVTNDWTR 266
Query: 492 SQIWLETTMA----KVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR-----KLALAQLRQ 542
+ LE A + E A + ++RL R+V R L++ + L QL
Sbjct: 267 CRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGG 326
Query: 543 ESCPLPPPVTDVSLELQQ-LREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVA 601
E V + L L LR +R +A L+ A L Q + E Q KV
Sbjct: 327 ELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALL----------QAQLEEQLRDKVL 376
Query: 602 QQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQELYGQALQE 656
++ + QQ Q L L V G ++ E + ++LT++ E +
Sbjct: 377 REKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQ 436
Query: 657 KVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRA 697
+ A +ET E L T R L +A +++ V L +R A
Sbjct: 437 EQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTA 477
Score = 56.6 bits (135), Expect = 9e-08
Identities = 65/247 (26%), Positives = 112/247 (45%), Gaps = 32/247 (12%)
Query: 493 QIWLETTMAKVEGAA-AQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 551
++ LET + +E + Q L R ++ ++ LI R++ L Q P+ P
Sbjct: 12 ELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALI-REIVTRNLSQPESPVLLPA 70
Query: 552 TDVSLELQQLREERNRLDAELQLSARLIQQEVGRARE---QGEAERQQLS----KVAQQL 604
T+++ L L+EE +L+QQE+ R + Q AER +L+ V+++L
Sbjct: 71 TEMA-SLLSLQEEN-----------QLLQQELSRVEDLLAQSRAERDELAIKYNAVSERL 118
Query: 605 EQELQ------QTQESLASLGLQLEVARQGQQESTEEAASLR--QELTQQQELYGQALQE 656
EQ L+ +TQE + +E+ RQ Q+E L+ QE Q+Q Q LQ
Sbjct: 119 EQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQG 178
Query: 657 KVAEVETR---LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEE 713
K+ + + R L +QL + L + R + L R +E++RS L ++
Sbjct: 179 KILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAM 238
Query: 714 ARKEEGQ 720
R++ Q
Sbjct: 239 LREQLDQ 245
Score = 31.6 bits (70), Expect = 3.2
Identities = 39/150 (26%), Positives = 67/150 (44%), Gaps = 31/150 (20%)
Query: 102 RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEV 161
R LD + D E GR R+ L G++ +A+ RQ+Q+L E +V
Sbjct: 1880 RTLDKVEREKLRSHEDTVRLSAEKGRLDRT--LTGAELELAEAQ---RQIQQL---EAQV 1931
Query: 162 RLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQREL 221
+L ++ ++ ++AQ +LE + E E LR+A A E R L
Sbjct: 1932 VVLEQSHSPAQLEVDAQQQQLEL--------QQEVERLRSAQAQTE-----------RTL 1972
Query: 222 EEVQRLHQEQLSSLTQAHEEALSSLTSKAE 251
E +R H++++ L EE +S+L + +
Sbjct: 1973 EARERAHRQRVRGL----EEQVSTLKGQLQ 1998
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 118 bits (296), Expect = 2e-26
Identities = 175/748 (23%), Positives = 303/748 (40%), Gaps = 112/748 (14%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 194
+ Q L ++ + +L +L E+ +LL ++ L+A+A ELE AE+A RA
Sbjct: 1120 QDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARA 1179
Query: 195 EAEGLRA-ALAGAEVVRKNLEEGS--------------------QRELEEVQRLHQEQLS 233
E RA A E + + LEE +RELEE H+ ++
Sbjct: 1180 RVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVA 1239
Query: 234 SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAG---EAKELA---EAQREAELLRKQLSK 287
+L + E + L + + L++ LE ++ E +LA E A+ ++L +
Sbjct: 1240 ALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCR 1299
Query: 288 TQEDLEAQVTL-VENLRKYVGEQVPSEVHSQTWELERQKLLE---------------TMQ 331
T ED ++ + VE L++ + + QT E +LLE Q
Sbjct: 1300 TYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQ 1359
Query: 332 HLQEDRDSLHATAE---LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
L+E R L ++ L VQ+L H L E+ + + L+ K + +
Sbjct: 1360 SLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQ-RLLSKANAEVA 1418
Query: 389 RWREKVFALMVQLKAQELEHSDSVKQLKGQ-----VASLQEKVTSQSQEQAILQRSLQDK 443
+WR K A +Q + +ELE + L+ Q V + K +S + + LQ +D
Sbjct: 1419 QWRSKYEADAIQ-RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDV 1477
Query: 444 AAEVEVERMGAKGL---QLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTM 500
E+E A L Q L RA E RRR +++ Q LE
Sbjct: 1478 TLELERATSAAAALDKKQRHLERALEERRRQEEE-----------------MQRELEAAQ 1520
Query: 501 AKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQ 560
+ G +L L + A+ + T+ K L++E L V+ +Q+
Sbjct: 1521 RESRGLGTELFRLRHGHEEALEALETL------KRENKNLQEEISDLTDQVSLSGKSIQE 1574
Query: 561 LREERNRLDAE-LQLSARLIQQEVGRAREQGEAERQQ--LSKVAQQLEQELQQTQESLAS 617
L + + L+ E ++ A L + E E+ + R Q LS+V +++++L + E A+
Sbjct: 1575 LEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECAN 1634
Query: 618 LGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLN 677
L R+ Q + E SL+ L + +AL+ ++ ++ L+D E +L
Sbjct: 1635 L-------RRNHQRAVE---SLQASLDAETRARNEALR-----LKKKMEGDLNDLELQLG 1679
Query: 678 EARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLML 737
A R+ +A + R +Q + +E+ E +RL E E+ Q L RR L + +
Sbjct: 1680 HATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELH-EQAQALERRASLLAAELEELR 1738
Query: 738 ATLQQEGLLSRYKQQRLLTVL----------PSLLDKKKSVVSSPRPPECSASAPVAAAV 787
A L+Q R +Q LL LL++KK + + S V A
Sbjct: 1739 AALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEAD----LAQLSGEVEEAA 1794
Query: 788 PTRESIKGSLSVLLDDLQDLSEAISKEE 815
R + + D ++E + KE+
Sbjct: 1795 QERREAEEKAKKAITDAAMMAEELKKEQ 1822
Score = 103 bits (256), Expect = 9e-22
Identities = 158/654 (24%), Positives = 268/654 (40%), Gaps = 80/654 (12%)
Query: 173 MRLEAQAMELEALARAEK---AGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQ 229
M+L + L A+AE+ A RAE GLR ALA AE R+ LEE +E +
Sbjct: 879 MKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQE-----K 933
Query: 230 EQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQ 289
L+ QA ++ L+ + L KS LE G+ KEL+E + E + L+ +
Sbjct: 934 NDLALQLQAEQDNLADAEERCHLLIKSKVQLE----GKVKELSERLEDEEEVNADLAARR 989
Query: 290 EDLEAQVT-LVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ 348
LE + T L +++ +E Q E + + L E M L E L + LQ
Sbjct: 990 RKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQ 1049
Query: 349 VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 408
Q L +E+ ++ + LE + E + + Q K ++
Sbjct: 1050 EAHQQALGDLQAEEDRVSALTKAKLRLEQQV------------EDLECSLEQEKKLRMDT 1097
Query: 409 SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEAR 468
+ ++L+G + QE V +Q++ L+ L+ K +E+ + + QL ++ Q+
Sbjct: 1098 ERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKI 1157
Query: 469 RRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYA-VRKVHTI 527
+ Q + EE+L A +++ +E A+ AA +L L+ RL A
Sbjct: 1158 KELQARAEELEEEL----EAERAARARVEKQRAE---AARELEELSERLEEAGGASAGQR 1210
Query: 528 RGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAR 587
G R+ L +LR+E LE LR E A L +++ A
Sbjct: 1211 EGCRKREAELGRLRRE------------LEEAALRHEAT--------VAALRRKQAEGAA 1250
Query: 588 EQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQ 647
E GE + L +V Q+LE+E + + + L +E + + S E+ ++ +
Sbjct: 1251 ELGE-QVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRA-KASAEKLCRTYEDQLSEA 1308
Query: 648 ELYGQALQEKVAEVET---RLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS 704
++ + LQ ++A+ T RL+ + + R L E + Q+ R A +
Sbjct: 1309 KIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE-------CLISQLSRGKALAAQSL 1361
Query: 705 QELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDK 764
+ELRR EE K + LA +Q L D +L+ ++E L LL K
Sbjct: 1362 EELRRQLEEESKAK-SALAHAVQALRHDCDLLREQHEEEA--------EAQAELQRLLSK 1412
Query: 765 KKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVC 818
+ V+ R S A A+ E ++ + L LQ+ E + A C
Sbjct: 1413 ANAEVAQWR------SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKC 1460
Score = 98.6 bits (244), Expect = 2e-20
Identities = 149/639 (23%), Positives = 265/639 (41%), Gaps = 65/639 (10%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 194
E S+ L + EV R+LE+E L++ K+ L E +A K
Sbjct: 970 ELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTE 1029
Query: 195 EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLE 254
E L ++A +K L+E HQ+ L L QA E+ +S+LT LE
Sbjct: 1030 EMAALDESVARLTKEKKALQEA-----------HQQALGDL-QAEEDRVSALTKAKLRLE 1077
Query: 255 KSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDL----EAQVTLVENLRKYVGEQV 310
+ + LE E K + +R L L TQE + + + L E L+K E
Sbjct: 1078 QQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELS 1137
Query: 311 PSEVHSQTWEL---ERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTR 367
+ + +L + QK ++ +Q E+ + + RV+ A + EEL+
Sbjct: 1138 QLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSE 1197
Query: 368 KVQPSDSL---EPEFTRKCQSLLNRWREKVFALMVQ----LKAQELEHSDSVKQLKGQVA 420
+++ + + E RK ++ L R R ++ ++ + A + ++ +L QV
Sbjct: 1198 RLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVD 1257
Query: 421 SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE 480
SLQ +E++ L+ + D AA VE L+RA+ ASAE+
Sbjct: 1258 SLQRVRQKLEKEKSELRMEVDDLAANVET-----------LTRAK----------ASAEK 1296
Query: 481 QLRLVVNAVSSSQIWLETTMAKVEGAAAQ---LPSLNNRLSYAVRKVHTIRGLIARKLAL 537
R + +S ++I +E ++ A+ Q L + + LS + + + ++R AL
Sbjct: 1297 LCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKAL 1356
Query: 538 A-----QLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 592
A +LR++ + ++ +Q LR + + L + + A Q E+ R + A
Sbjct: 1357 AAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE-AQAELQRLLSKANA 1415
Query: 593 E-RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASL-RQELTQQQELY 650
E Q SK Q ++ +E+ L L+L+ A +G + + + +SL + +L Q E
Sbjct: 1416 EVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESE 1475
Query: 651 GQALQ-EKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRR 709
L+ E+ L ++ ER L E RR+ + L QR + LR
Sbjct: 1476 DVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRH 1535
Query: 710 LQEEA------RKEEGQRLARRLQELERDKNLMLATLQQ 742
EEA K E + L + +L +L ++Q+
Sbjct: 1536 GHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQE 1574
Score = 89.7 bits (221), Expect = 1e-17
Identities = 135/649 (20%), Positives = 259/649 (39%), Gaps = 98/649 (15%)
Query: 96 HQDVSERRLDTQR------PQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVR 149
H++ +E + + QR +V W +D ++ ++ L + + +
Sbjct: 1396 HEEEAEAQAELQRLLSKANAEVAQWRSKYEAD-----------AIQRTEELEEAKKKLAL 1444
Query: 150 QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 209
+LQE E + + K+RL+ ++ ++ + A + + L A
Sbjct: 1445 RLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEE 1504
Query: 210 RKNLEEGSQRELEEVQRLHQ---EQLSSLTQAHEEALSSL-TSKAE--GLEKSLSSLETR 263
R+ EE QRELE QR + +L L HEEAL +L T K E L++ +S L +
Sbjct: 1505 RRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQ 1564
Query: 264 RAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELER 323
+ K + E ++ + L + S+ Q LE E
Sbjct: 1565 VSLSGKSIQELEKTKKALEGEKSEIQAALE----------------------------EA 1596
Query: 324 QKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC 383
+ LE E+ +L EL QV+ E+ RK+ D +C
Sbjct: 1597 EGALEL-----EETKTLRIQLELSQVKA------------EVDRKLAEKD-------EEC 1632
Query: 384 QSLLNRWREKVFALMVQLKAQELEHSDSV---KQLKGQVASLQEKV---TSQSQEQAILQ 437
+L + V +L L A+ ++++ K+++G + L+ ++ T Q+ E
Sbjct: 1633 ANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAAT 1692
Query: 438 RSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLE 497
R +Q + E + R + L EL +A R A+ E+LR + S+ E
Sbjct: 1693 RLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAE 1752
Query: 498 TTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL--ALAQLRQESCPLPPPVTDVS 555
+ + L S N L +K+ ++ ++ A + R+ +TD +
Sbjct: 1753 QELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAA 1812
Query: 556 LELQQLREERN------RLDAELQLSARLIQQEVGRAREQ----GEAERQQLSKVAQQLE 605
+ ++L++E++ R+ L+ + R +Q + A + G+ + Q+L ++LE
Sbjct: 1813 MMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELE 1872
Query: 606 QELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRL 665
EL Q+ A + + +E +A R+ L + Q+L + LQ KV
Sbjct: 1873 AELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDK-LQSKVKS----Y 1927
Query: 666 REQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 714
+ Q + E++ N ++ KA L + RA + ++ +LR +A
Sbjct: 1928 KRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDA 1976
Score = 75.5 bits (184), Expect = 2e-13
Identities = 135/627 (21%), Positives = 249/627 (39%), Gaps = 69/627 (11%)
Query: 252 GLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVP 311
GL L L +R + L +A+ L+R + + +A T+ N+R +
Sbjct: 817 GLLGVLEELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAF------ 870
Query: 312 SEVHSQTWELERQKLLETMQHLQEDRDSLHATAEL---------LQVRVQSL--THILAL 360
+ V + +W K+ ++ Q + + AEL + + Q L TH+
Sbjct: 871 NAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSIT 930
Query: 361 QEE-ELTRKVQPSDSLEPEFTRKCQSLLN---RWREKVFALMVQLKAQELEHS------- 409
QE+ +L ++Q + +C L+ + KV L +L+ +E ++
Sbjct: 931 QEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRR 990
Query: 410 ---DSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQE 466
D +LK + L+ + +E+ + +++ E+ L E QE
Sbjct: 991 KLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQE 1050
Query: 467 ARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHT 526
A ++ + E++ V+A++ +++ LE + +E + Q L A RK+
Sbjct: 1051 AHQQALGDLQAEEDR----VSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLE- 1105
Query: 527 IRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLR---EERNRLDAELQLSARLIQQEV 583
L + ++A Q+ L + EL QL E+ L A++Q + +Q
Sbjct: 1106 -GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARA 1164
Query: 584 GRAREQGEAERQQLSKVAQQ---LEQELQQTQESLASLGLQLEVARQGQQESTEEAASLR 640
E+ EAER ++V +Q +EL++ E L G R+G ++ E LR
Sbjct: 1165 EELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLR 1224
Query: 641 QELTQ---QQELYGQALQEKVAEVETRLREQLSDTER---RLNEARREHAKAVVSLRQIQ 694
+EL + + E AL+ K AE L EQ+ +R +L + + E V L
Sbjct: 1225 RELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANV 1284
Query: 695 RRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQE-GLLSRYKQQR 753
+ K +++L R E+ + E + LQ D + LQ E G LSR
Sbjct: 1285 ETLTRAKASAEKLCRTYED-QLSEAKIKVEELQRQLADASTQRGRLQTESGELSR----- 1338
Query: 754 LLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQ------DL 807
LL++K+ ++S + A+ + E + S L +Q DL
Sbjct: 1339 -------LLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDL 1391
Query: 808 SEAISKEEAVCQGDNLDRCSSSNPQMS 834
+EEA Q + S +N +++
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVA 1418
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 115 bits (287), Expect = 2e-25
Identities = 172/695 (24%), Positives = 288/695 (41%), Gaps = 87/695 (12%)
Query: 97 QDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQA--------EVIV 148
+D +R +T+R + ++ + D++E RR R LE + QQ E
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEE-RRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 149 RQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEV 208
R+ Q L+R EEE RL + +Q++R E Q E L + E+ R E E L +
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRRE-QEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 209 VR-----KNLEEGSQREL--------------EEVQRLHQE----QLSSLTQAHEEALSS 245
R K EE Q+ L EEV+RL QE Q + EE
Sbjct: 573 ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQ 632
Query: 246 LTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKY 305
L E E+ L + ++ + + E E L ++L + E+ + L E ++
Sbjct: 633 LLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 306 VGEQVPSEVHSQTWELE-----RQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILAL 360
E++ S + W+LE RQ + + QE + E + R L
Sbjct: 693 ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW---- 748
Query: 361 QEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVA 420
QEEE + Q + +FT + Q+ EK +L A+ +QL+ +
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQA-----EEKSERGRQRLSARPPLREQRERQLRAEER 803
Query: 421 SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE 480
+E+ +E+ QR Q + E E++ + + +L R + A++ +++ E+
Sbjct: 804 QQREQRFLPEEEEKE-QRRRQRREREKELQFLEEEE---QLQRRERAQQLQEEEDGLQED 859
Query: 481 QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQL 540
Q R Q W QL R + HT L A+ QL
Sbjct: 860 QERRRSQEQRRDQKW-----------RWQLEEERKR------RRHT---LYAKPALQEQL 899
Query: 541 RQESCPLPPPVTDVSLELQQLREERNRLDAELQL--SARLIQQEVGRAREQGEAERQQLS 598
R+E L ++ E RE+R R + E Q +L Q+E RE+ E R+Q
Sbjct: 900 RKEQQLLQEEEEELQREE---REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 599 KVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKV 658
+ + +++LQQ +E L LG + E R+ ++E +EL Q++E Q L+E
Sbjct: 957 ERQYRKDKKLQQKEEQL--LGEEPEKRRRQEREKKYRE---EEELQQEEE---QLLRE-- 1006
Query: 659 AEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEE 718
E E R R++ R+ +E ++E + + R+ +R +E++ +E QEE +
Sbjct: 1007 -EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065
Query: 719 GQRLARRLQELERDKNLMLATLQQEGLLSRYKQQR 753
+R RR QELER Q+E L R + ++
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Score = 98.6 bits (244), Expect = 2e-20
Identities = 162/717 (22%), Positives = 280/717 (39%), Gaps = 48/717 (6%)
Query: 59 LARSSRDHRNLRRRGNIDGWRQNLEPSN--NVEMFPPSGHQDVSERRLDTQRPQVTMWER 116
L R R+ + +RR D Q E E + + E QR E+
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ 277
Query: 117 DVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLE 176
+RQE RR R + Q L ++ ++ +Q +E R +EE R +E QQ+ R E
Sbjct: 278 LRKLERQEL-RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE 336
Query: 177 AQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRE--LEEVQRLHQEQLSS 234
Q + R ++ R + E R E + E+ +RE L Q+L +EQ
Sbjct: 337 QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 235 LTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEA 294
Q + E+ L + R + +E E + E E ++L + QE+
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 295 QVTLVENLRKYVGEQVPSEVHSQTWELERQ---KLLETMQHLQEDRDSLHATAELLQVRV 351
+ E ++ E+ ++ E R+ KL E + Q++R E + R
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERRE 516
Query: 352 QSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDS 411
Q L +EE L ++++ L E + + LL R EK + + + E +
Sbjct: 517 QRLKR--QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEER 574
Query: 412 VKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRW 471
QL + +++ + QE+ + QR +++ +E E + + L R + R
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE----ERREQRLKREEPEEERR 630
Query: 472 QQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLI 531
QQ S E++ R Q E + + E RL +++ H
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEE--------EERLEQRLKREHEEE--- 679
Query: 532 ARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGE 591
R+ LA+ QE + E + R + + E + AR + +++G+
Sbjct: 680 RREQELAEEEQEQ----------ARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Query: 592 AERQQLSKVAQQLEQELQQTQESLASLGLQLEVAR-----QGQQESTEEAA----SLRQE 642
RQ+ + ++ E ELQ +E A Q E R Q Q E E S R
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR--RAAQE 700
L +Q+E +A + + E E+ + RR R + + + Q+QR RA Q
Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 701 KERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRY--KQQRLL 755
+E L+ QE R +E +R + +LE ++ TL + L K+Q+LL
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL 906
Score = 97.1 bits (240), Expect = 6e-20
Identities = 154/695 (22%), Positives = 281/695 (40%), Gaps = 91/695 (13%)
Query: 101 ERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEE 160
ERR + + R+ +R+E R Q +Q E R+ Q+LRR +EE
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE--RREQQLRREQEE 370
Query: 161 VRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRE 220
R ++ +Q++R E Q + L R ++ +R+ + +++
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQ------------------LRREQQLRREQQ 412
Query: 221 LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQR-EAE 279
L Q+L +EQ L + EE + E E+ L + R K E +R E E
Sbjct: 413 LRREQQLRREQ--QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470
Query: 280 LLRKQLSKTQED--LEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDR 337
++QL + QE+ E + L E R+ E+ ++ + E R++ L+ + + +
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ-EERREQRLKRQEEEERLQ 529
Query: 338 DSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNR-------- 389
L + +L + + + +L +EE+ + + L+ E + LL R
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Query: 390 -WREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVE 448
RE+ L +LK +E+E ++Q + + L+ + + + Q +L+ Q++ + +
Sbjct: 590 LKREQEERLEQRLKREEVER---LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646
Query: 449 VERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAA 508
+ R + + L R +E R Q+ EE+ R A + E +++
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706
Query: 509 QLPS-LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE--- 564
QL S + R S + G R+ + R+ L + + QQ E+
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 565 --------------RNRLDA--------ELQLSARLIQQEVGR------AREQGEAERQQ 596
R RL A E QL A QQ R +EQ +R++
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Query: 597 LSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQ----------- 645
K Q LE+E Q + A QL+ G QE E S Q Q
Sbjct: 827 REKELQFLEEEEQLQRRERAQ---QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883
Query: 646 --QQELYGQ-ALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
+ LY + ALQE++ + + L+E+ + +R E RR + RQ + ++E
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE----RQYREEEQLQQE 939
Query: 703 RSQELRRLQEEARKEEGQRLARRLQELERDKNLML 737
Q LR +E+ R++E +R R+ ++L++ + +L
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974
Score = 94.0 bits (232), Expect = 5e-19
Identities = 156/700 (22%), Positives = 292/700 (41%), Gaps = 65/700 (9%)
Query: 61 RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGHQDVSERRLDTQRPQVTMWERDVSS 120
R R+ L+R+ +R + S+ + P V + ++ + + + + S
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256
Query: 121 DRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAM 180
++ + L G Q + + R Q R EE +L RE + K R + ++
Sbjct: 1257 QLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR-DRKSQ 1315
Query: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 240
E + L R E+ + + E + + EE R E ++ +E+L H+
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR-----HQ 1370
Query: 241 EALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVE 300
E + + L + E + E ++L +RE +L + + K +E+ E Q++ E
Sbjct: 1371 EQGRKFLEEEQRLRRQ--ERERKFLKEEQQLRCQEREQQLRQDRDRKFREE-EQQLSRQE 1427
Query: 301 NLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILAL 360
RK+ E+ +V Q E ER+ L E Q QE +LLQ R
Sbjct: 1428 RDRKFREEE--QQVRRQ--ERERKFLEEEQQLRQERHRKFREEEQLLQER---------- 1473
Query: 361 QEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQE-----LEHSDSVKQL 415
+E++L R+ + LE E + Q ++RE+ +L++QE LE + +
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ------ELRSQEPERKFLEEEQQLHRQ 1527
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARR-RWQQQ 474
+ Q LQE+ + QE+ +R +D+ E E++ + + +LSR + R+ R ++Q
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE-EQLRQEREEQQLSRQERDRKFRLEEQ 1586
Query: 475 TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 534
+EQ R + E + + EG L R+ + +
Sbjct: 1587 KVRRQEQERKFMED--------EQQLRRQEGQQ----QLRQERDRKFREDEQLLQEREEQ 1634
Query: 535 LALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAER 594
Q R P QQLR +R+R E ++++ + E+ + R
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE--------EEQLLQEGEEQQLRR 1686
Query: 595 QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL 654
Q+ + ++ EQ+L++ + L + ++ RQ + E LRQE T+Q++L Q
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQE-TEQEQLRRQER 1745
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 714
K+ E E +LR + + + R E R+ + Q+++ +++ RSQE R +
Sbjct: 1746 YRKILE-EEQLRPEREEQQLRRQERDRKFREE----EQLRQEREEQQLRSQESDR---KF 1797
Query: 715 RKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRL 754
R+EE R R Q+L + ++E L ++QRL
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL 1837
Score = 91.3 bits (225), Expect = 3e-18
Identities = 165/677 (24%), Positives = 278/677 (41%), Gaps = 103/677 (15%)
Query: 123 QEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSL-------QQKMRL 175
+EPG+R R E + L++ E Q ++ RLE+ R R+ L Q++
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEE----QSEKQERLEQRDRQRRDEELWRQRQEWQEREER 186
Query: 176 EAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSL 235
A+ +L++ E + E LR E+ RK EE Q+ E R+ QE+
Sbjct: 187 RAEEEQLQSCKGHETEEFPDEEQLRRREL-LELRRKGREEKQQQRRERQDRVFQEEEEKE 245
Query: 236 TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQ 295
+ E L E+ L E +R E +E E R+ E R++L + +++ E Q
Sbjct: 246 WRKRETVLRKE-------EEKLQEEEPQRQRELQEEEEQLRKLE--RQELRRERQEEEQQ 296
Query: 296 VTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLT 355
+ ++ +Q Q E+Q+ E QE+R E + R Q L
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQ----QEERREQQLRREQEERREQQLR 352
Query: 356 HILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQL 415
++EE R+ Q E E R+ Q L RE+ QL+ ++ + +QL
Sbjct: 353 R----EQEEERREQQLRREQEEE--RREQQLR---REQQLRREQQLRREQQLRRE--QQL 401
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ + +E+ + Q+ Q+ +++ E ++ + + L R QE RR W ++
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR- 460
Query: 476 ASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL 535
EE ET + E QL R+
Sbjct: 461 ---EE----------------ETERHEQERRKQQLKRDQEE---------------ERRE 486
Query: 536 ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQ 595
+L +E E Q+ RE++ R + E + RL +QE +Q Q
Sbjct: 487 RWLKLEEEE----------RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQ 536
Query: 596 QLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL- 654
QL + ++ ++L + +E +LE R+ Q+ E+ Q L +++E Q L
Sbjct: 537 QLRREQEERREQLLKREEE-----KRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 655 QEKVAEVETRLR----EQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRL 710
+E+ +E RL+ E+L ERR +RE + +Q+ + QE+ R Q+LRR
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQRLKREEPEE-ERRQQLLKSEEQEERRQQQLRRE 650
Query: 711 QEE------ARKEEGQRLARRL--QELERDKNLMLATLQQEGLLSRYKQQ--RLLTVLPS 760
Q+E R+EE +RL +RL + E + LA +QE R K + + L S
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 761 LLDKKKS-VVSSPRPPE 776
D ++S V S PR E
Sbjct: 711 EADARQSKVYSRPRKQE 727
Score = 87.4 bits (215), Expect = 5e-17
Identities = 167/705 (23%), Positives = 285/705 (40%), Gaps = 93/705 (13%)
Query: 61 RSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGHQDVSER-RLDTQRPQVTMWERDVS 119
+ RD RRR W+Q E ++ R R + Q+ ER+
Sbjct: 1274 QQERDREQERRR-----WQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 120 SDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETS---LQQKMRLE 176
RQE R+ R E Q L ++ E +R+ + R+ EE +E L+++ RL
Sbjct: 1329 RRRQETDRKFR----EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 177 AQAMELEALARAEKAGRAEAEG-LRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSL 235
Q E + L ++ E E LR + RK EE Q +E R +E+ +
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQ-----DRDRKFREEEQQLSRQERDRKFREEEQQV 1439
Query: 236 TQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQ 295
+ E K E+ L R+ E ++L + + E +L R++ + + E Q
Sbjct: 1440 RRQERER------KFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 296 VTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLT 355
+ E RK+ +++ S+ E ER K LE Q L + E Q+R Q
Sbjct: 1494 LRRQERDRKFREQELRSQ------EPER-KFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546
Query: 356 HILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQ-LKAQE-----LEHS 409
+ ++ RK + + L E R+ Q L + R++ F L Q ++ QE +E
Sbjct: 1547 Q---QRRQDRDRKFREEEQLRQE--REEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 410 DSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGL-QLELSRAQEAR 468
+++ +GQ QE+ +++ +LQ + + E +R + QL ++
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661
Query: 469 RRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIR 528
R + + EEQL + Q+ + K QL + + R
Sbjct: 1662 RHDRDRKFREEEQL---LQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRR 1718
Query: 529 GLIARKLALA-QLRQESCPLPPPVTDVSLELQQLR-EERNRLDAELQLSARLIQQEVGRA 586
+ RK QLRQE+ E +QLR +ER R E ++++
Sbjct: 1719 QELERKFREEEQLRQET------------EQEQLRRQERYRKILE--------EEQLRPE 1758
Query: 587 REQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQ 646
RE+ + RQ+ + ++ EQ Q+ +E ++ Q E LRQE ++
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQ--------QLRSQESDRKFREEEQLRQE-REE 1809
Query: 647 QELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQE 706
Q+L Q K E +L QL + E+RL + R +A ++ A QEK R +E
Sbjct: 1810 QQLRPQQRDGKYRWEEEQL--QLEEQEQRLRQERDRQYRAE------EQFATQEKSRREE 1861
Query: 707 LRRLQEEARK---EEGQRLAR---RLQELERDKNLMLATLQ-QEG 744
QEE +K E ++L R Q+ E ++ + ++ QEG
Sbjct: 1862 QELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEG 1906
Score = 81.3 bits (199), Expect = 4e-15
Identities = 154/642 (23%), Positives = 255/642 (39%), Gaps = 71/642 (11%)
Query: 101 ERRLDTQRPQVTMWERDVSSDRQEPGRRG--RSWGLEGSQALSQQAEVIVRQLQELRRLE 158
E+RL + P+ ++ + S+ QE R+ R E + ++ E R Q L+R
Sbjct: 617 EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676
Query: 159 EEVR----LLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLE 214
EE R L E Q + R++++ + + +E R R + R+ E
Sbjct: 677 EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736
Query: 215 EGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEA 274
E +R E+Q +E+ + Q EE T + + EKS R+ A+
Sbjct: 737 EKRRRRESELQ-WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG---RQRLSARPPLRE 792
Query: 275 QREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQ-KLLETMQHL 333
QRE +L ++ + ++ + E R+ E+ E Q E E Q + E Q L
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER---EKELQFLEEEEQLQRRERAQQL 849
Query: 334 QEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEP---EFTRKCQSLLNRW 390
QE+ D L E + + Q Q EE ++ + + +P E RK Q LL
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL--- 906
Query: 391 REKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVE 450
Q + +EL+ + K+ + + + QE+ L R ++K E E
Sbjct: 907 ---------QEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 451 RMGAKGLQLELSRAQ--------------EARRRWQQQTASAEEQLRLVVNAVSSSQIWL 496
R K +L+ Q E + R +++ EEQL Q W
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 497 ETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSL 556
K E L +L R+ ++ + +L+QE L +
Sbjct: 1018 RQYRKKDE-----LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERET-- 1070
Query: 557 ELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLA 616
+Q E + R + ELQ Q+E RE+ E R+Q + + E+ELQQ +E L
Sbjct: 1071 RRRQELERQYRKEEELQ------QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL- 1123
Query: 617 SLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRL 676
L R+ ++ E +E QQ+E Q L+E E E R R++L R
Sbjct: 1124 -----LREEREKRRRQELERQYREEEEVQQEE--EQLLRE---EPEKRRRQELERQYREE 1173
Query: 677 NEARREHAKAVVSLRQIQRRAAQEKERS-QELRRLQEEARKE 717
E ++E + LR+ Q + QE+ER +E LQ + RK+
Sbjct: 1174 EELQQEEEQL---LREEQEKRRQERERQYREEEELQRQKRKQ 1212
Score = 80.1 bits (196), Expect = 8e-15
Identities = 169/757 (22%), Positives = 313/757 (41%), Gaps = 81/757 (10%)
Query: 43 WRWRSRPLHCVPPFSPLARSSRDHRNLRRRGNIDGWRQNL----EPSNNVEMFPPSGHQD 98
W+W++ +S R + L R + R+ E + F P +
Sbjct: 769 WQWQAEE-----------KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK 817
Query: 99 VSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGL-EGSQALSQQAEVIVRQLQELRR- 156
RR +R + E + ++ RR R+ L E L + E R+ QE RR
Sbjct: 818 EQRRRQRREREK----ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER--RRSQEQRRD 871
Query: 157 ------LEEEVRLLRET-----SLQQKMRLEAQAM--ELEALARAEKAGRAEAEGLRAAL 203
LEEE + R T +LQ+++R E Q + E E L R E+ R E R
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931
Query: 204 AGAEVVRKN----LEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSS 259
++ ++ EE +R +E +R +++ L Q E+ L K E+
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKD-KKLQQKEEQLLGEEPEKRRRQERE--- 987
Query: 260 LETRRAGEAKELAEAQREAELLRKQLSKTQ-EDLEAQVTLVENLRKYVGEQVPSEVHSQT 318
++ E +EL Q E +LLR++ K + ++ E Q + L++ EQ+ E +
Sbjct: 988 ---KKYREEEELQ--QEEEQLLREEREKRRRQEWERQYRKKDELQQEE-EQLLREEREKR 1041
Query: 319 WELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPE 378
ER++ + LQ++ + L E + R + +EEEL ++ + EPE
Sbjct: 1042 RLQERERQYREEEELQQEEEQL--LGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 379 FTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR 438
R+ Q + RE+ +Q + ++L + K+ + ++ + QE+ L R
Sbjct: 1100 KRRR-QERERQCREEE---ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 439 SLQDKAAEVEVERMGAKGLQLE------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSS 492
+K E+ER + +L+ L QE RR+ +++ EE+L+
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 493 QIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVT 552
+ + + +N++ R+ R L +L Q +Q+ L
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 553 DVSLELQQLR-EERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQT 611
+ E ++ R ++R+R E + R Q+E R R++ E +QL + ++ ++ Q+T
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR-RDRKSQEEKQLLREEREEKRRRQET 1334
Query: 612 ------QESLASLGLQLEVARQGQQESTEEAASLRQE-----LTQQQELYGQALQEKVAE 660
+E L + + RQ + E QE L ++Q L Q + K +
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLK 1394
Query: 661 VETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARK--EE 718
E +LR Q + E++L + R + Q R + +E Q++RR QE RK EE
Sbjct: 1395 EEQQLRCQ--EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR-QERERKFLEE 1451
Query: 719 GQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLL 755
Q+L + R++ +L +++ L + + ++ L
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Score = 79.7 bits (195), Expect = 1e-14
Identities = 135/561 (24%), Positives = 235/561 (41%), Gaps = 87/561 (15%)
Query: 197 EGLRAALAGAE-VVRKNLEEGSQRELEEVQR-LHQEQLSSLTQAHEEALSSLTSKAEGLE 254
E RA G E +++ +E QR E R L +E Q +E L E E
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 255 KSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE--AQVTLVENLRKYVGEQVPS 312
K E E + QR E L +Q + QE E A+ +++ + + E+ P
Sbjct: 157 KQ----------ERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206
Query: 313 EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPS 372
E +L R++LLE + +E++ Q RV QEEE
Sbjct: 207 EE-----QLRRRELLELRRKGREEKQQQRRER---QDRV--------FQEEE-------- 242
Query: 373 DSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQE 432
E E+ RK +++L + EK+ Q + + E + +++L+ Q L+ + + Q+
Sbjct: 243 ---EKEW-RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ--ELRRERQEEEQQ 296
Query: 433 QAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSS 492
Q L+R Q + + E R Q E R Q+ RR +QQ E+QLR
Sbjct: 297 QQRLRREQQLRRKQEEERRE-----QQEERREQQERR--EQQEERREQQLRREQEERREQ 349
Query: 493 QIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVT 552
Q+ E + E + R +R+ +R QLR+E
Sbjct: 350 QLRREQEEERREQQLRREQE-EERREQQLRREQQLR-------REQQLRREQ-------- 393
Query: 553 DVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQ 612
+ E Q RE++ R + +L+ +L +++ + R + E ER + ++ EQ L++ Q
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQ--QLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 613 ESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDT 672
E R+ + EE QE +QQ Q + + ++ E+
Sbjct: 452 EE-----------RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Query: 673 ERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERD 732
ERR + RRE + R+ + + +E+ER Q+ R +++ R+E+ + RR Q L+R+
Sbjct: 501 ERREQQLRREQEER----REQRLKRQEEEERLQQRLRSEQQLRREQEE---RREQLLKRE 553
Query: 733 KNLMLATLQQEGLLSRYKQQR 753
+ L ++E L R +++R
Sbjct: 554 EEKRLEQERREQRLKREQEER 574
Score = 77.8 bits (190), Expect = 4e-14
Identities = 178/761 (23%), Positives = 311/761 (40%), Gaps = 107/761 (14%)
Query: 59 LARSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFPPSGHQDVSERRLDTQ-RPQVTMWERD 117
L R R+ R L+ R +R+ E E + + L+ Q R + + + +
Sbjct: 1033 LLREEREKRRLQERER--QYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 118 VSSDRQEPGRRGRSWG---LEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSL----- 169
R+EP +R R + L Q+ E ++R+ +E RR +E R RE
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 170 QQKMRLEAQA---MELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQR 226
+Q +R E + ELE R E+ + E E L L + R+ E RE EE+QR
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQL---LREEQEKRRQERERQYREEEELQR 1207
Query: 227 LHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLS 286
++Q E+ S L + E E A ++ RE E R+
Sbjct: 1208 QKRKQ----RYRDEDQRSDLKWQWEP--------EKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 287 KTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRD---SLHAT 343
D ++Q ++L+ +GEQ + E ER++ + +H E+
Sbjct: 1256 SQLRDRQSQ----QDLQHLLGEQ-----QERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306
Query: 344 AELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT----RKCQSLLNRWREKVFALMV 399
A+ + Q +L + EE R+ + E R+ Q L + R++ F
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR-EE 1365
Query: 400 QLKAQE-----LEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGA 454
+L+ QE LE +++ + + L+E+ + QE+ R +D+ E +++
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 455 KGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLN 514
+ + ++ RR +++ EE+ +L + + E E QL
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQL---RQERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 515 NRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQL-REERNRLDAELQ 573
+ + R RK +LR + P E QQL R++R R LQ
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQE-----PERKFLEEEQQLHRQQRQR--KFLQ 1535
Query: 574 LSARLIQQEVGRAREQG-------------EAERQQLSKVAQQL-----EQELQQTQESL 615
+L +QE G+ R Q E E QQLS+ + EQ++++ ++
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 616 ASLGLQLEVARQ-GQQESTEEA-------ASLRQELTQQQELYGQALQEKVAEVETRLRE 667
+ + ++ RQ GQQ+ +E L QE ++Q+L+ Q K E E +LR
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE-REEQQLHRQERDRKFLEEEPQLRR 1654
Query: 668 QLSDTERRLNEARR--------EHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARK--E 717
Q + + R + R+ + + RQ + R +E+E Q+LRR QE RK +
Sbjct: 1655 QEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE--QQLRR-QERERKFLQ 1711
Query: 718 EGQRLARRLQELE---RDKNLMLATLQQEGLLSRYKQQRLL 755
E Q+L R QELE R++ + +QE L + + +++L
Sbjct: 1712 EEQQLRR--QELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 114 bits (284), Expect = 5e-25
Identities = 162/691 (23%), Positives = 279/691 (40%), Gaps = 115/691 (16%)
Query: 166 ETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQ 225
ETS+++K+ L + M+ + + G A+AG + + +EE ++ EEV+
Sbjct: 330 ETSVRRKVSLVLEKMQPLVMV---------SSGSTKAVAGQGELTRKVEELQRKLDEEVK 380
Query: 226 RLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQL 285
+ +++L E L T + L++ L RR GEA++ + + + L Q
Sbjct: 381 K--RQKLEPSQVGLERQLEEKTEECSRLQELLE----RRKGEAQQSNKELQNMKRLLDQG 434
Query: 286 SKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAE 345
+ LE QV ++N K+V P++ E+ + LLET + L+E + E
Sbjct: 435 EDLRHGLETQVMELQNKLKHVQGPEPAK------EVLLKDLLETRELLEEVLEGKQRVEE 488
Query: 346 LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQE 405
L++R + LT + +EE V + QE
Sbjct: 489 QLRLRERELTALKGALKEE----------------------------------VASRDQE 514
Query: 406 LEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQ 465
+EH +Q + L+ + +Q+ A+L+ Q +A V +GLQ EL
Sbjct: 515 VEHVR--QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALV-------RGLQRELEETS 565
Query: 466 EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 525
E WQ +E LR ++ Q L+ M K E L ++ R++
Sbjct: 566 EETGHWQSMFQKNKEDLR------ATKQELLQLRMEKEE----MEEELGEKIEVLQRELE 615
Query: 526 TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGR 585
R + L++E + ++ E Q D EL+ +++ E R
Sbjct: 616 QARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADR 675
Query: 586 AREQGEAERQQLSKVAQQLEQELQQTQ------ESLASLGLQLEVA-----RQGQQESTE 634
RE E + QL K QQL Q+ ++ E+ A++ Q A R+ Q+E+ E
Sbjct: 676 GREL-EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDE 734
Query: 635 ---EAASLRQELTQQQELY--GQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVS 689
L Q+L + + L G+A++ ++ + RL + E LN ++ E +
Sbjct: 735 FRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAA 794
Query: 690 -------LRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLAT--- 739
L + QR A+ + Q L R EE K+ + L R ELE K L+ T
Sbjct: 795 KRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR-EVLRRGKAELEEQKRLLDRTVDR 853
Query: 740 ----LQQEGLLSRYKQQRLLTVLPSLLDK-KKSVVSSPRPPECSASAPVAAAVPTRESIK 794
L++ G S+ Q+L L +K ++ V + R + AS E
Sbjct: 854 LNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWAS--------EAEKTS 905
Query: 795 GSLSVLLDDLQDLSEAISKEEAVCQGDNLDR 825
G LS L D++Q L +A+ +A LD+
Sbjct: 906 GGLSRLQDEIQRLRQALQASQAERDTARLDK 936
Score = 103 bits (256), Expect = 9e-22
Identities = 176/728 (24%), Positives = 307/728 (42%), Gaps = 139/728 (19%)
Query: 145 EVIVRQLQELRRLEEEVRLLRETSLQQKMRL-EAQAMELEALARAEKAGR---------- 193
EV+++ L E R L EEV L + +++++RL E + L+ + E A R
Sbjct: 463 EVLLKDLLETRELLEEV-LEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQ 521
Query: 194 --AEAEGLRAALAGA-------EVVRKN---LEEGSQRELEEV-------QRLHQEQLSS 234
+ E LR ++ A E R+ L G QRELEE Q + Q+
Sbjct: 522 YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581
Query: 235 LTQAHEEALSSLTSKAEGLEKSLSSLET--RRAGEAKELAEAQREAELLRKQLSKTQEDL 292
L +E L K E E+ +E R +A+ A R+ E+L+K+L +TQE+L
Sbjct: 582 LRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEEL 641
Query: 293 EAQVTLVENLRKYVGEQVPSEVHSQT----------WELERQ--KLLETMQHLQEDRDSL 340
+ ++ ++ G E+ Q ELE Q +L +T+Q L++D +
Sbjct: 642 K-ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA 700
Query: 341 HATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC----------------- 383
+ + L A E L + +D EF R+
Sbjct: 701 SKAKMVAEAEATVLGQRRAAVETTLRETQEEND----EFRRRILGLEQQLKETRGLVDGG 756
Query: 384 QSLLNRWREKVFALMVQLKAQELEHSDSVKQ------------LKGQVASLQEKVTSQSQ 431
+++ R R+K+ L + + Q+LE + + Q L+ ++ Q + Q
Sbjct: 757 EAVEARLRDKLQRL--EAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQ 814
Query: 432 EQAILQRSLQDKAAEVEVERMGAKGLQ--------------LELSRAQEARRRWQQQTAS 477
EQ L R+L+++ + EV R G L+ EL + E ++ QQ +
Sbjct: 815 EQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQA 874
Query: 478 -----AEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRG--- 529
E+ R V +A ++ W + K G ++L RL A++ R
Sbjct: 875 QLEDYKEKARREVADAQRQAKDW-ASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTAR 933
Query: 530 ----LIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAEL---QLSARLIQQE 582
L+A++ L L QE+ D + +L+ L E+ +RL+ EL + + L+
Sbjct: 934 LDKELLAQR--LQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDR 991
Query: 583 VGRAREQGEAERQQL--SKVAQQ--------LEQELQQTQESLASL-GLQLEVARQGQQE 631
V R R+Q + R +L + A+Q LE++ + + LAS G Q A Q E
Sbjct: 992 VNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLE 1051
Query: 632 STEEAASLRQELTQQQELYGQALQEKVAEVETRLRE---QLSDTERRLNEARREHAKAVV 688
S + L QE Q +E LQ ++E +++E Q+ D + +N+ + + + V
Sbjct: 1052 SQNQ---LLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVK 1108
Query: 689 SLRQIQRRAAQEKERSQELRRLQE---EARKEEGQRLARRLQELERD------KNLMLAT 739
+L++ A +E ER LR+ + E + E ++L R++ LE+D ++ +
Sbjct: 1109 ALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESA 1168
Query: 740 LQQEGLLS 747
L+ EGL S
Sbjct: 1169 LKNEGLSS 1176
Score = 97.8 bits (242), Expect = 4e-20
Identities = 165/738 (22%), Positives = 314/738 (42%), Gaps = 134/738 (18%)
Query: 101 ERRLDTQ-------RPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQE 153
+R+LD + P ER + +E R LE + +QQ+ ++LQ
Sbjct: 372 QRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQEL--LERRKGEAQQSN---KELQN 426
Query: 154 LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNL 213
++RL ++ LR LE Q MEL+ + + E L L + + +
Sbjct: 427 MKRLLDQGEDLRHG-------LETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEV 479
Query: 214 EEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAE 273
EG QR +EE RL + +L++L A +E ++S + E + + +
Sbjct: 480 LEGKQR-VEEQLRLRERELTALKGALKEEVASRDQEVEHVRQ-----------------Q 521
Query: 274 AQREAELLRKQLSKTQED---LEAQ----VTLVENLRKYVGEQVPSEVHSQTW------- 319
QR+ E LR+ + +D LEA+ LV L++ + E H Q+
Sbjct: 522 YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKED 581
Query: 320 -ELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL------THILALQEEELTRKVQPS 372
+Q+LL+ +E + L E+LQ ++ T + + ++EL R +
Sbjct: 582 LRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEEL 641
Query: 373 DSLEPEFTRKCQSLLNRWR----EKVFALMV-------QLKAQELEHSDSVKQLKGQVAS 421
L+ E R+ Q + R R EK A++ +L+ Q L+ +++QL+
Sbjct: 642 KELQAE--RQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEE 699
Query: 422 LQE-------KVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSR---------AQ 465
+ + T Q +A ++ +L++ E + R GL+ +L A
Sbjct: 700 ASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAV 759
Query: 466 EARRRWQQQTASAE-EQLRLVVNA-------VSSSQIWLETTMAKVEGAAAQLPSLNNRL 517
EAR R + Q AE +QL +NA +++++ LE + + + A+L L
Sbjct: 760 EARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTL 819
Query: 518 SYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNR----LDAELQ 573
+ A+ + R ++ R A+L ++ L V ++ EL+++ E+ + L A+L+
Sbjct: 820 NRALEEEGKQREVLRR--GKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLE 877
Query: 574 LSARLIQQEVGRAREQGE---AERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQ 630
++EV A+ Q + +E ++ S +L+ E+Q+ +++L + + + AR ++
Sbjct: 878 DYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKE 937
Query: 631 ESTEEAASLRQELTQQQELYG------QALQEKVAEVETRLREQLSDTER---RLNEARR 681
+ L QE ++ + L+EKV+ +ET L E+ + E R+N R
Sbjct: 938 LLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRD 997
Query: 682 EHAKAVVSLRQIQRRAAQEKERSQ-ELRRLQEEAR-------------------KEEGQR 721
+ + L Q +R A Q+ E + L R ++ + + + Q
Sbjct: 998 QVDQLRTELMQ-ERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQL 1056
Query: 722 LARRLQELERDKNLMLAT 739
L RLQ ER+K ++ +T
Sbjct: 1057 LQERLQAEEREKTVLQST 1074
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 109 bits (273), Expect = 9e-24
Identities = 155/743 (20%), Positives = 319/743 (42%), Gaps = 85/743 (11%)
Query: 101 ERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQ-ELRRLEE 159
E +DT+ + + E+ + + +G+ +E QAL+ Q + +++LQ + LEE
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGK---IEDEQALAIQLQKKIKELQARIEELEE 1124
Query: 160 EVRLLRETSLQQKMRLEAQAMELEALA-RAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQ 218
E+ R + + + + + ELE ++ R E+AG A + A E+ +K E +
Sbjct: 1125 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS-------AQIEMNKKREAEFQK 1177
Query: 219 --RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQR 276
R+LEE H+ ++L + H ++++ L + + L++ LE ++ E+ +
Sbjct: 1178 MRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLAS 1237
Query: 277 EAELLRK------QLSKTQEDLEAQVTLVENLRKYVGEQVPSE---VHSQTWELERQ--- 324
E + K ++ +T ED +++ E ++ + ++ ++ +H+++ E RQ
Sbjct: 1238 NMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE 1297
Query: 325 -----------------KLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTR 367
++ E + L+E+ + A LQ S H L E+
Sbjct: 1298 KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQ----SARHDCDLLREQYEE 1353
Query: 368 KVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVT 427
+ + L+ + K S + +WR K +Q + +ELE ++ K+L ++ +E V
Sbjct: 1354 EQEAKAELQRGMS-KANSEVAQWRTKYETDAIQ-RTEELE--EAKKKLAQRLQDAEEHVE 1409
Query: 428 SQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVN 487
+ + + A L+++ Q EVE L +++ R+ A ++ + ++ L
Sbjct: 1410 AVNSKCASLEKTKQRLQNEVE-------DLMIDVERSNAACIALDKKQRNFDKVLAEWKQ 1462
Query: 488 AVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPL 547
+Q LE + + + +L + N ++ + T+ K L+QE L
Sbjct: 1463 KYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETL------KRENKNLQQEISDL 1516
Query: 548 PPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQEVGRAREQGEAERQQL--SKVAQQL 604
+ + + +L + + +LD E +L L + E E+G+ R QL ++V ++
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 605 EQELQQTQESLASLGLQ-LEVARQGQQESTEEAASLRQELTQQQELYGQALQEKV----- 658
++++ + E L L L V Q E S L ++++ G + ++
Sbjct: 1577 DRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHA 1636
Query: 659 ----AEVETRLREQ---LSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQ 711
AE LR L DT+ L++A R L ++RRA + +ELR
Sbjct: 1637 NRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASL 1696
Query: 712 EEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSS 771
E R E G+++A + + L+ + + L Q L++ K +L T + + + + +V
Sbjct: 1697 E--RTERGRKMAEQ-ELLDASERVQLLHTQNTSLINTKK--KLETDISQIQGEMEDIVQE 1751
Query: 772 PRPPECSASAPVAAAVPTRESIK 794
R E A + A E +K
Sbjct: 1752 ARNAEEKAKKAITDAAMMAEELK 1774
Score = 87.0 bits (214), Expect = 6e-17
Identities = 122/613 (19%), Positives = 264/613 (43%), Gaps = 73/613 (11%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 194
E ++ + E+ + R+LE+E L++ ++ L E A K
Sbjct: 925 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE 984
Query: 195 EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAH---EEALSSLTSKAE 251
E GL +A +K L+E Q+ L+++Q + ++++++LT+A E+ + L E
Sbjct: 985 EMAGLDETIAKLTKEKKALQEAHQQTLDDLQ-MEEDKVNTLTKAKTKLEQQVDDLEGSLE 1043
Query: 252 GLEKSLSSLETRR---AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGE 308
+K LE + G+ K E+ + E ++QL+ E L+ + + NL+ + +
Sbjct: 1044 QEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLN---EKLKKKEFEMSNLQGKIED 1100
Query: 309 QVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRK 368
+ Q ++ QK ++ +Q E+ + + + + L+ + EE++ +
Sbjct: 1101 E-------QALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 369 VQP---SDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ----ELEHSDSVKQLKGQVAS 421
++ + S + E +K ++ + R + +Q +A +H+DSV +L Q+ S
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDS 1213
Query: 422 LQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQ 481
LQ +E++ L+ + D A+ +E +A+ +++ + E+Q
Sbjct: 1214 LQRVKQKLEKEKSELKMEINDLASNMET--------------VSKAKANFEKMCRTLEDQ 1259
Query: 482 LRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL-----A 536
L ++++ + L N LS ++HT G +R+L
Sbjct: 1260 L------------------SEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 537 LAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQ 596
++QL + + ++ +L++ + ++ L LQ SAR + REQ E E++
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQ-SAR---HDCDLLREQYEEEQE- 1356
Query: 597 LSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQE 656
+L++ + + +A + E + E EEA + Q E + +A+
Sbjct: 1357 ---AKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNS 1413
Query: 657 KVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR---RAAQEKERSQELRRLQEE 713
K A +E + ++ E + + R +A A ++L + QR + E ++ E + + E
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERSNA-ACIALDKKQRNFDKVLAEWKQKYEETQAELE 1472
Query: 714 ARKEEGQRLARRL 726
A ++E + L+ L
Sbjct: 1473 ASQKESRSLSTEL 1485
Score = 77.4 bits (189), Expect = 5e-14
Identities = 126/637 (19%), Positives = 259/637 (40%), Gaps = 94/637 (14%)
Query: 151 LQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVR 210
L +L+ E++V L + K +LE Q +LE EK + E + L G +
Sbjct: 1011 LDDLQMEEDKVNTLTKA----KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLA 1066
Query: 211 KNLE---EGSQRELEEVQRLHQEQLSSLTQAHEEA----------LSSLTSKAEGLEKSL 257
+ E +++L E + + ++S+L E+ + L ++ E LE+ +
Sbjct: 1067 QESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI 1126
Query: 258 SSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL-------VENLRKYVGEQV 310
+ RA K+ ++ RE E + ++L + AQ+ + + +R+ + E
Sbjct: 1127 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEST 1186
Query: 311 PSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQ 370
H T R+K +++ L E DSL + L+ L ++ +L ++
Sbjct: 1187 LQ--HEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELK----MEINDLASNME 1240
Query: 371 PSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQS 430
+ F + C++L ++ E +K +E E + +L Q A L
Sbjct: 1241 TVSKAKANFEKMCRTLEDQLSE--------IKTKEEEQQRLINELSAQKARLHT------ 1286
Query: 431 QEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAE----------- 479
E R L +K A V ++G Q + +E +R+ +++T +
Sbjct: 1287 -ESGEFSRQLDEKDAMVS---QLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH 1342
Query: 480 --EQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLAL 537
+ LR ++ L+ M+K AQ R Y + L K L
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRGMSKANSEVAQW-----RTKYETDAIQRTEELEEAKKKL 1397
Query: 538 AQLRQESCPLPPPVTDVSLELQQLRE------ERNRLDAELQLSARLIQQEVGRAREQGE 591
AQ Q++ V L++ ++ E +D E +A + + R ++
Sbjct: 1398 AQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVL 1457
Query: 592 AERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYG 651
AE +Q ++ + EL+ +Q+ SL +L + +ES + +L++E
Sbjct: 1458 AEWKQKY---EETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE--------N 1506
Query: 652 QALQEKVAEVETRLREQLSDTERRLNEARR-----EHAKAVVSLRQIQRRAAQEKERSQE 706
+ LQ+++++ L EQ+++ + ++E + +H K+ + + A+ E E +
Sbjct: 1507 KNLQQEISD----LTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI 1562
Query: 707 LRRLQE--EARKEEGQRLARRLQELERDKNLMLATLQ 741
LR E + + E +++A + +EL++ K L ++
Sbjct: 1563 LRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVE 1599
Score = 76.3 bits (186), Expect = 1e-13
Identities = 125/622 (20%), Positives = 263/622 (42%), Gaps = 117/622 (18%)
Query: 263 RRAGEAKELAEAQREAELLRKQLSKTQ----EDLEAQVTLVENLRKYVGEQVPSEVHSQT 318
+ A KE+A + E E +++L+KT+ E E VTL++
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQ--------------EKND 890
Query: 319 WELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPE 378
+L+ Q + + +E D L T L+ ++ +E+T + + + + E
Sbjct: 891 LQLQVQAEADALADAEERCDQLIKTKIQLEAKI-----------KEVTERAEDEEEINAE 939
Query: 379 FT---RKCQSLLNRWREKVFALMVQL-KAQELEHS--DSVKQLKGQVASLQEKVTSQSQE 432
T RK + + ++ + L + L K ++ +H+ + VK L ++A L E + ++E
Sbjct: 940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKE 999
Query: 433 QAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT----ASAEEQLRLVVNA 488
+ LQ + Q ++++E + +++ +A+ + +QQ S E++ +L ++
Sbjct: 1000 KKALQEAHQQTLDDLQME-------EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD- 1051
Query: 489 VSSSQIWLETTMAKVEG-----------AAAQLPSLNNRLSYAVRKVHTIRGLIARKLAL 537
LE K+EG LN +L ++ ++G I + AL
Sbjct: 1052 -------LERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQAL 1104
Query: 538 A-QLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQ 596
A QL+++ L + ++ E++ R R + + + +R +++ R E G A Q
Sbjct: 1105 AIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ 1164
Query: 597 L----------SKVAQQLEQELQQTQ-----------ESLASLGLQLEVARQGQQESTEE 635
+ K+ + LE+ Q + +S+A LG Q++ ++ +Q+ +E
Sbjct: 1165 IEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKE 1224
Query: 636 AASLRQE---LTQQQELYGQA----------LQEKVAEVETRLREQLSDTERRLNEARRE 682
+ L+ E L E +A L+++++E++T+ EQ +R +NE +
Sbjct: 1225 KSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQ----QRLINELSAQ 1280
Query: 683 HAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQ 742
A+ + R+ ++ +L R ++A ++ + L R+L+E + K+ + LQ
Sbjct: 1281 KARLHTESGEFSRQLDEKDAMVSQLSR-GKQAFTQQIEELKRQLEEETKAKSTLAHALQS 1339
Query: 743 -----EGLLSRY-KQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
+ L +Y ++Q L + K S V+ R + A+ E ++ +
Sbjct: 1340 ARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR------TKYETDAIQRTEELEEA 1393
Query: 797 LSVLLDDLQDLSEAISKEEAVC 818
L LQD E + + C
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKC 1415
Score = 53.1 bits (126), Expect = 1e-06
Identities = 113/571 (19%), Positives = 222/571 (38%), Gaps = 111/571 (19%)
Query: 153 ELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKN 212
EL ++E R L + K E LE L R K + E L +A
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIA-------- 1521
Query: 213 LEEGSQR--ELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKE 270
EG + ELE+V++ + S L + EEA +SL + + + L ++ ++
Sbjct: 1522 --EGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRK 1579
Query: 271 LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETM 330
+AE E + L++ + E +++ + +E+ S+ L +K +E
Sbjct: 1580 IAEKDEELDQLKRNHLRVVESMQS--------------TLDAEIRSRNDALRIKKKME-- 1623
Query: 331 QHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRW 390
+L ++ +Q L H Q E R ++ + +
Sbjct: 1624 -------------GDLNEMEIQ-LNH-ANRQAAEALRNLRNTQGI--------------- 1653
Query: 391 REKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVE 450
LK +L D++ +GQ ++ A+++R AEVE
Sbjct: 1654 ----------LKDTQLHLDDAI---RGQ--------DDLKEQLAMVERRANLMQAEVE-- 1690
Query: 451 RMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLV---VNAVSSSQIWLETTMAKVEGAA 507
L+ L R + R+ +Q+ A E+++L+ ++ +++ LET +++++G
Sbjct: 1691 -----ELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEM 1745
Query: 508 AQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNR 567
+ +K T ++A +L Q D S L+++++ +
Sbjct: 1746 EDIVQEARNAEEKAKKAITDAAMMAEELKKEQ-------------DTSAHLERMKKNMEQ 1792
Query: 568 LDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQ 627
+LQL RL + E A + G+ + Q+L ++LE E++ Q+ L +
Sbjct: 1793 TVKDLQL--RLDEAE-QLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849
Query: 628 GQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARR-----E 682
+E T + R+ + + Q+L + LQ KV + + E + L + R+ E
Sbjct: 1850 RVKELTYQTEEDRKNILRLQDLVDK-LQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE 1908
Query: 683 HAKAVVSLRQIQRRAAQEKERSQELRRLQEE 713
AK + + Q + K R + + EE
Sbjct: 1909 EAKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 53.1 bits (126), Expect = 1e-06
Identities = 84/378 (22%), Positives = 151/378 (39%), Gaps = 89/378 (23%)
Query: 152 QELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAG---RAEAEGLRAALAGAEV 208
+ LR L +L++T L + Q E LA E+ +AE E LRA+L E
Sbjct: 1642 EALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTER 1701
Query: 209 VRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEA 268
RK E+ E VQ LH + +SL + + LE +S ++ GE
Sbjct: 1702 GRKMAEQELLDASERVQLLHTQN------------TSLINTKKKLETDISQIQ----GEM 1745
Query: 269 KELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLE 328
+++ + R AE K ++ + + E L+K EQ +
Sbjct: 1746 EDIVQEARNAE------EKAKKAITDAAMMAEELKK---EQ------------------D 1778
Query: 329 TMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLN 388
T HL+ + ++ T + LQ+R+ + E+L K ++ Q L
Sbjct: 1779 TSAHLERMKKNMEQTVKDLQLRLD--------EAEQLALK---------GGKKQIQKLEA 1821
Query: 389 RWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVE 448
R RE L ++++++ + ++VK L+ +R +++ + E
Sbjct: 1822 RVRE----LESEVESEQKHNVEAVKGLRKH------------------ERRVKELTYQTE 1859
Query: 449 VERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAA 508
+R LQ + + Q + +++Q AEEQ + + Q LE + + A +
Sbjct: 1860 EDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAES 1919
Query: 509 QLPSLNNRLSYAVRKVHT 526
Q+ N+L R+VHT
Sbjct: 1920 QV----NKLRVKSREVHT 1933
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 109 bits (272), Expect = 1e-23
Identities = 171/742 (23%), Positives = 314/742 (42%), Gaps = 105/742 (14%)
Query: 147 IVRQLQELRRLEEEVRLLRETSLQQKMRLE----------AQAMELEALARAEKAGRAEA 196
+ RQ +E+ EEE+ +RE L + RL A+ ++L+ +AE AEA
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899
Query: 197 EGLRAALAG----AEVVRKNLEEGSQRELEEVQRLHQE---------QLSSLTQAHEEAL 243
E LRA L E + +LE + E E Q L E +L + E A
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESAR 959
Query: 244 SSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSK----TQEDLEAQVTLV 299
L + E L LE + + + +E +LL ++++ E+ E +L
Sbjct: 960 QKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019
Query: 300 ENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILA 359
+ K+ E + E +RQ+L +T + L+ D L LQ ++ L LA
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 360 LQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSVKQLK- 416
+EEEL + +E E +K +L + ++ L L+++ + + KQ +
Sbjct: 1080 KKEEELQAALA---RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD 1136
Query: 417 ----------------GQVASLQEKVTSQSQEQAILQRSLQDKAA--EVEVERMGAK--- 455
A+ QE + + QE IL+++L+++A E +++ M K
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 456 -----GLQLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVEGAAAQ 509
QLE ++ +A +QT E +L V + + E KVE AQ
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVE---AQ 1253
Query: 510 LPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLD 569
L L + + R +R +A K+ Q+ ++ + ++ + +L ++ + L+
Sbjct: 1254 LQELQVKFNEGER----VRTELADKVTKLQVELDN--VTGLLSQSDSKSSKLTKDFSALE 1307
Query: 570 AELQLSARLIQQE------VGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLE 623
++LQ + L+Q+E + +Q E E+ + ++ E+ ++ +A+L Q+
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 624 VARQGQQEST---EEAASLRQELTQQQELYGQALQEKVA------EVETRLREQLSDTER 674
++ ++S E A ++++L + E Q +EKVA + +TRL+++L D
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV 1427
Query: 675 RLNEARREHAKAVVSLRQIQRRAAQEK----ERSQELRRLQEEARKEEGQ--RLARRLQE 728
L+ R+ ++ + A+EK + ++E R + EAR++E + LAR L+E
Sbjct: 1428 DLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEE 1487
Query: 729 LERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVP 788
++Q+ L R +Q T + L+ K V S E S A
Sbjct: 1488 ----------AMEQKAELERLNKQ-FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV-- 1534
Query: 789 TRESIKGSLSVLLDDLQDLSEA 810
E +K L L D+LQ +A
Sbjct: 1535 --EEMKTQLEELEDELQATEDA 1554
Score = 104 bits (259), Expect = 4e-22
Identities = 165/809 (20%), Positives = 337/809 (41%), Gaps = 105/809 (12%)
Query: 102 RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEV 161
RR + QR ++ R + D + + + ++ Q A+ L R+EEE
Sbjct: 1037 RREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEA 1096
Query: 162 RLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKNLEEG---- 216
+ +L++ LE+Q EL+ +E+A R +AE + L E ++ LE+
Sbjct: 1097 AQ-KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155
Query: 217 -------SQRE---------LEEVQRLHQEQLSSLTQAHEEALSSLTSKAE-------GL 253
S+RE LEE + H+ Q+ + Q H +A+ L + E L
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 254 EKSLSSLETRR---AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQV 310
EK+ +LE R A E K L + + ++E RK++ ++L+ + E +R + ++V
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 311 P-------------SEVHSQTWELERQ------KLLETMQHLQED-RDSLHATAELLQVR 350
S+ S++ +L + +L +T + LQE+ R L + +L QV
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Query: 351 VQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSD 410
+ + L+EEE + +LE + + + ++ ++ A+E++
Sbjct: 1336 DEKNSFREQLEEEE-----EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 411 SVKQLKGQVASLQEKVTSQSQEQAI---LQRSLQDKAAEVEVERMGAKGLQLELSRAQEA 467
K L+G +EKV + + + LQ+ L D +++ +R A L+ + + +
Sbjct: 1391 Q-KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL 1449
Query: 468 RRRWQQQTAS-AEEQLRLVVNAVSSSQIWLETTMAKVEGAA--AQLPSLNNRLSYAVRKV 524
+ +A AEE+ R A L A E A+L LN + + +
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Query: 525 HTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREE-------RNRLDAELQLSAR 577
+ + + + ++ +L + L V ++ +L++L +E + RL+ LQ
Sbjct: 1510 MSSKDDVGK--SVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 578 LIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQE--------------SLASLGLQLE 623
++++ EQ E +++QL + +++E EL+ ++ L L ++
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627
Query: 624 VARQGQQESTEEAASLRQEL-----------TQQQELYGQAL--QEKVAEVET---RLRE 667
A + + E+ ++ L+ ++ ++E+ QA ++K+ +E +L+E
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687
Query: 668 QLSDTERRLNEARREHAKAVVSLRQIQRRA--AQEKERSQELRRLQEEARKEEGQRLARR 725
+L+ ER +A++E + + + A E++R E R Q E EE Q
Sbjct: 1688 ELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTEL 1747
Query: 726 LQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAA 785
+ + + NL + + + L R Q+ L + K + + E + + A
Sbjct: 1748 INDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKA 1807
Query: 786 AVPTRESIKGSLSVLLDDLQDLSEAISKE 814
++ E+ L LD+ +A K+
Sbjct: 1808 SITALEAKIAQLEEQLDNETKERQAACKQ 1836
Score = 93.2 bits (230), Expect = 9e-19
Identities = 140/626 (22%), Positives = 257/626 (41%), Gaps = 52/626 (8%)
Query: 137 SQALSQQAEVIVRQLQELRRL-EEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAE 195
S L++ + QLQ+ + L +EE R S + K + + E L E+A
Sbjct: 1296 SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNL 1355
Query: 196 AEGLRAALAGAEVVRKNLEE--GSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 253
+ + A ++K +E+ G EEV+R Q+ L L+Q HEE +++ + L
Sbjct: 1356 EKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY----DKL 1411
Query: 254 EKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 313
EK+ + L+ +L ++ A L K+ K + L + T+ KY E+ +E
Sbjct: 1412 EKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA---KYAEERDRAE 1468
Query: 314 VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL----------THILALQEE 363
++ E + L ++ E + L + + ++ L H L +
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR 1528
Query: 364 ELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQ 423
L ++V+ + E + Q+ + L V L+A + + + L+G+ +
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQAT----EDAKLRLEVNLQAMKAQFE---RDLQGRDEQSE 1581
Query: 424 EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLR 483
EK ++ ++ L+D+ + + K L+++L + + A +QLR
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641
Query: 484 LVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRL-SYAVRKVHTIRGLIARKLALAQLRQ 542
+ + L+ T A E AQ +L S + L A + A Q +Q
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQ 1701
Query: 543 ESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE--RQQLSKV 600
E L + + S + EE+ RL+A R+ Q E EQG E +L K
Sbjct: 1702 ERDELADEIANSSGKGALALEEKRRLEA------RIAQLEEELEEEQGNTELINDRLKKA 1755
Query: 601 AQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELT----QQQELYGQALQE 656
Q++Q + S + E ARQ + +E QE+ + + AL+
Sbjct: 1756 NLQIDQ-INTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEA 1814
Query: 657 KVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQI---QRRAAQEKE-------RSQE 706
K+A++E +L + + + + RR K L Q+ +R A Q K+ R ++
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 707 LRRLQEEARKEEGQRLARRLQELERD 732
L+R EEA +EE QR ++L+R+
Sbjct: 1875 LKRQLEEA-EEEAQRANASRRKLQRE 1899
Score = 92.4 bits (228), Expect = 2e-18
Identities = 104/486 (21%), Positives = 209/486 (43%), Gaps = 46/486 (9%)
Query: 280 LLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDS 339
L RK +K Q+ L A L N Y+ ++ + W K+ +Q +++ +
Sbjct: 794 LARKAFAKRQQQLTAMKVLQRNCAAYL------KLRNWQWWRLFTKVKPLLQVSRQEEEM 847
Query: 340 LHATAELLQVRVQSL------THILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREK 393
+ EL++VR + L T + LQ + + K+Q + L+ E T C +
Sbjct: 848 MAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE-TELCA--------E 898
Query: 394 VFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMG 453
L +L A++ E + L+ +V +E+ E+ +Q+++Q+ ++E E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 454 AKGLQLE-------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGA 506
+ LQLE L + +E + + Q ++ +L+ + ++ T + + E
Sbjct: 959 RQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE----FTTNLTEEEEK 1014
Query: 507 AAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERN 566
+ L L N+ + + L + +L + L TD+S ++ +L+ +
Sbjct: 1015 SKSLAKLKNKHEAMITDLE--ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 567 RLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVAR 626
L +L +Q + R E+ + L K+ ++LE ++ + QE L S A
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKI-RELESQISELQEDLESERASRNKAE 1131
Query: 627 QGQQESTEEAASLRQEL-------TQQQELYGQALQEKVAEVETRLREQLSDTERRLNEA 679
+ +++ EE +L+ EL QQEL + QE V ++ L E+ E ++ E
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE-VNILKKTLEEEAKTHEAQIQEM 1190
Query: 680 RREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQ---ELERDKNLM 736
R++H++AV L + + + K ++ ++ E R E + LQ + E + +
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV 1250
Query: 737 LATLQQ 742
A LQ+
Sbjct: 1251 EAQLQE 1256
Score = 73.6 bits (179), Expect = 7e-13
Identities = 94/457 (20%), Positives = 201/457 (43%), Gaps = 57/457 (12%)
Query: 97 QDVSERRLDTQR--PQVTMWERDVSSDRQEPGRRGRSWGLEGSQ-ALSQQAEVIVRQLQE 153
++ E++ + +R Q D+ S + + G+ LE S+ AL QQ E + QL+E
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE--LEKSKRALEQQVEEMKTQLEE 1543
Query: 154 LRRLEEEVRLLRETSLQQKMRLEAQAMELEA---------------LARAEKAGRAEAEG 198
L E+E++ + L+ ++ L+A + E L R + AE E
Sbjct: 1544 L---EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 199 LRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLS 258
R + A RK LE +L++++ + S + +EA+ L ++ +
Sbjct: 1601 ERKQRSMAVAARKKLE----MDLKDLEA----HIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 259 SLETRRAGEAKELAEAQREAELLRK---QLSKTQEDLEAQVTL---VENLRKYVGEQVPS 312
L+ RA + LA+A+ + L+ ++ + QE+L A + R + +++ +
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 313 EVHSQTWELERQKLLET-MQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQP 371
LE ++ LE + L+E+ + EL+ R++ LQ +++ +
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN----LQIDQINTDL-- 1766
Query: 372 SDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQE----LEHSDSVKQLKGQVASLQEKVT 427
+LE +K ++ + + L V+L+ E ++ S+ L+ ++A L+E++
Sbjct: 1767 --NLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD 1824
Query: 428 SQSQEQAIL-------QRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE 480
++++E+ ++ L+D +V+ ER A+ + + +A ++ ++Q AEE
Sbjct: 1825 NETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEE 1884
Query: 481 QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRL 517
+ + + Q LE + ++ SL N+L
Sbjct: 1885 EAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 54.3 bits (129), Expect = 5e-07
Identities = 77/359 (21%), Positives = 152/359 (42%), Gaps = 37/359 (10%)
Query: 134 LEGSQALSQQAEV-IVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAG 192
L+G S++ + +VRQ++E+ E+ R R ++ + +LE +LEA +
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632
Query: 193 RAEA-EGLRAALAGAEVVRKNLEE--GSQRELEEVQRLHQEQLSSLT----QAHEEALSS 245
R EA + LR A + + L++ S+ E+ + ++++L S+ Q EE ++
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692
Query: 246 LTSKAEGLEK--SLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLR 303
+K + ++ L+ +G+ E +R E QL + E+ + L+ +
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752
Query: 304 KYVGEQVPS--------EVHSQTWELERQKLLETMQHLQEDRDSLHATAEL-LQVRVQSL 354
K Q+ H+Q E RQ+L + L+ + T + + + +L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812
Query: 355 THILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQL----------KAQ 404
+A EE+L D+ E C+ + R +K+ +++Q+ K Q
Sbjct: 1813 EAKIAQLEEQL-------DNETKERQAACKQV-RRTEKKLKDVLLQVDDERRNAEQYKDQ 1864
Query: 405 ELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSR 463
+ S +KQLK Q+ +E+ + + LQR L+D + L+ +L R
Sbjct: 1865 ADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 49.7 bits (117), Expect = 1e-05
Identities = 58/244 (23%), Positives = 105/244 (43%), Gaps = 22/244 (9%)
Query: 582 EVGRAREQGEAERQQLSKV------AQQLEQELQQTQESLASLGLQLEVARQGQQESTEE 635
+V R E+ A+ ++L KV A+ E++ Q L + LQL+ Q + E E
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 636 AASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR 695
A LR LT ++ Q L+E ++E R+ E+ E R + E K ++++++
Sbjct: 899 AEELRARLTAKK----QELEEICHDLEARVEEE----EERCQHLQAEKKKMQQNIQELEE 950
Query: 696 RAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLL 755
+ +E+ Q+L+ E+ E + Q + D+N LA +E L +
Sbjct: 951 QLEEEESARQKLQ--LEKVTTEAKLKKLEEEQIILEDQNCKLA---KEKKLLEDRIAEFT 1005
Query: 756 TVLPSLLDKKKSVVSSPRPPEC---SASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAIS 812
T L +K KS+ E + R+ ++ + L D DLS+ I+
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 813 KEEA 816
+ +A
Sbjct: 1066 ELQA 1069
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 108 bits (269), Expect = 3e-23
Identities = 177/777 (22%), Positives = 320/777 (41%), Gaps = 127/777 (16%)
Query: 138 QALSQQAEVIVRQLQELRRLEEEVR----------LLRETSLQQKMRLEAQAMELEALAR 187
Q QA++ +LQ L + EEE++ L + +L+ L+AQ EL+
Sbjct: 1070 QIAELQAQIDELKLQ-LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 188 AEKAGRAEAEGLRAALAGA-EVVRKNLEE-----GSQREL---------------EEVQR 226
+EKA R +AE + L+ E ++ LE+ +Q+EL EE +
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 227 LHQEQLSSLTQAHEEALSSLTSKAE-------GLEKSLSSLET---RRAGEAKELAEAQR 276
H+ Q+ + Q H AL L+ + E LEK+ LET A E K L + +
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 277 EAELLRKQLSKTQEDLEAQVTLVENLRKYVGE---QVPSEVHSQTWELE--RQKLLETMQ 331
E+E RK+L ++L A+V+ + LR + E ++ +E+ + + LE +K ++ +
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 332 HLQEDRDSLHATAELLQVRVQSLTHILA--LQEEELTRKVQPSDSLEPEFTRKCQSLLNR 389
L T ELLQ + ++ + Q EE +Q E E + +
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE----- 1363
Query: 390 WREKVFALMVQLK------AQELEHSDSVKQLKGQVASLQEKVTSQSQEQAI-------- 435
++V AL QL +L +S+++ K ++ E ++ + +E+A+
Sbjct: 1364 --KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 436 ---LQRSLQDKAAEVEVERMGAKGLQLE-------LSRAQEARRRWQQQTASAEEQLR-L 484
LQ+ L D +++ +R A L+ + L+ + R+ ++ AE + R
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK 1481
Query: 485 VVNAVSSSQIWLETTMAKVE------GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALA 538
A+S ++ E AK E A + L + + VH + K AL
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE---KSKRALE 1538
Query: 539 QLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLS 598
Q +E + + ++ ELQ + + RL+ +Q ++++ EQ E +++ L
Sbjct: 1539 QQVEE---MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 599 KVAQQLEQELQQTQE--------------SLASLGLQLEVARQGQ--------------- 629
K ++LE EL+ ++ L L Q+E A + +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 630 --QESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTE--RRLNEARREHAK 685
Q EEA + R E+ Q + + L+ AE+ +L+E+L+ +E RR E R+
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEI-LQLQEELASSERARRHAEQERDELA 1714
Query: 686 AVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGL 745
++ + A +++R E R Q E EE Q L + R L + TL E
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 746 LSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD 802
R Q+ L + K + + + E + + A + E+ G L L+
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831
Score = 105 bits (261), Expect = 2e-22
Identities = 166/716 (23%), Positives = 294/716 (41%), Gaps = 101/716 (14%)
Query: 147 IVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAME------------LEALARAEKAGRA 194
+ RQ +EL+ +EE LL+ Q K+ E + ME L +AE A
Sbjct: 847 VTRQEEELQAKDEE--LLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 195 EAEGLRAALAG----AEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKA 250
EAE +RA LA E + +LE + E E Q L E+ QAH + L +
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK--KKMQAHIQDLEEQLDEE 962
Query: 251 EG------LEKSLSSLETRRAGEAKELAEAQ-----REAELLRKQLSKTQEDLEAQVTLV 299
EG LEK + + ++ E L E Q +E +L+ ++++ L +
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 300 ENLRKYVGEQ----VPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLT 355
+NL K +Q E + E RQ+L + + L + L LQ ++ L
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 356 HILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQL 415
LA +EEEL Q L R ++ LK V++L
Sbjct: 1083 LQLAKKEEEL------------------QGALARGDDETLHKNNALKV--------VREL 1116
Query: 416 KGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQT 475
+ Q+A LQE S+ + ++ +D + E+E + + + QE R + +Q+
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 476 A----SAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLI 531
A + EE+ + + + T + ++ Q L + + T +
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL 1236
Query: 532 ARKL-ALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQE---VGRAR 587
A ++ L Q++ ES + EL E +RL EL A +Q E V
Sbjct: 1237 ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLL 1296
Query: 588 EQGEAERQQLSKVAQQLEQELQQTQE----------SLASLGLQLEVARQGQQESTEEAA 637
E+ E + + +K A LE +LQ TQE +L+S QLE + QE EE
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 638 SLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQ-IQRR 696
R+ L +Q ALQ ++A+ + ++ + L E L EA+++ K +L Q ++ +
Sbjct: 1357 EARKNLEKQV----LALQSQLADTKKKVDDDLGTIE-SLEEAKKKLLKDAEALSQRLEEK 1411
Query: 697 AAQEKERSQELRRLQEE-----ARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQ 751
A + + RLQ+E + +++A L++ ++ + +LA +++ + +RY +
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA--EEKSISARYAE 1469
Query: 752 QRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDL 807
+R D+ ++ S + + A+ +E + L D++DL
Sbjct: 1470 ER---------DRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 93.6 bits (231), Expect = 7e-19
Identities = 148/675 (21%), Positives = 281/675 (41%), Gaps = 122/675 (18%)
Query: 155 RRLEEEVRLLRETSLQ---QKMRLEAQAMELEA---------LARAEKAGRAEAEGLRAA 202
+ L EV++L++ + ++ +L+AQ EL A + AEKA + + E +
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293
Query: 203 LAGAEVVRKNLEEGS-----QRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSL 257
E +K ++ + +L++ Q L QE+ +L+S+ LE+
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL--------NLSSRIRQLEEEK 1345
Query: 258 SSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVP-SEVHS 316
+SL+ ++ E + +++ L+ QL+ T++ ++ + +E+L + + + +E S
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 317 QTWE---LERQKLLETMQHLQEDRDSL-------HATAELLQVRVQSLTHILALQEEELT 366
Q E L KL +T LQ++ D L A L+ + + +LA ++
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 367 RKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKV 426
R + D E E K L+ R AL L+A+E E KQL+ + L
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLAR----ALEEALEAKE-EFERQNKQLRADMEDLMSSK 1520
Query: 427 TSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRW--------------- 471
+ L++S + +VE R + L+ EL ++A+ R
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580
Query: 472 QQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLI 531
Q + EE+ RL++ V + LE + A A + L ++
Sbjct: 1581 QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK-- 1638
Query: 532 ARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE---------------LQLSA 576
AR + QLR+ L + D EL++ R R+ + A+ LQL
Sbjct: 1639 ARDEVIKQLRK----LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Query: 577 RLIQQEVGRAREQGEAERQQLS----------------------KVAQQLEQELQQTQES 614
L E RAR E ER +L+ ++AQ LE+EL++ Q +
Sbjct: 1695 ELASSE--RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQ-LEEELEEEQSN 1751
Query: 615 LASLG-------LQLEVARQ---GQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR 664
+ L LQ++ ++ + +++ + RQ+L +Q + LQE V+++
Sbjct: 1752 MELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811
Query: 665 LREQLSDTERR---LNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEAR-----K 716
+ +S E + L E + AK + ++ RR EK+ + ++++E R K
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT--EKKLKEIFMQVEDERRHADQYK 1869
Query: 717 EEGQRLARRLQELER 731
E+ ++ R+++L+R
Sbjct: 1870 EQMEKANARMKQLKR 1884
Score = 91.3 bits (225), Expect = 3e-18
Identities = 130/612 (21%), Positives = 264/612 (43%), Gaps = 71/612 (11%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 194
E +Q L + + + +Q+L E +L E +QK++LE E + E+
Sbjct: 936 ERNQILQNEKKKMQAHIQDL-----EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 990
Query: 195 EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLE 254
E + + + +++ + E S + EE ++ + L+ + E +S L + + E
Sbjct: 991 EDQNSKF-IKEKKLMEDRIAECSSQLAEEEEKA--KNLAKIRNKQEVMISDLEERLKKEE 1047
Query: 255 KSLSSLETRRA---GEAKEL----AEAQREAELLRKQLSKTQEDLEAQVTL--VENLRKY 305
K+ LE + GE +L AE Q + + L+ QL+K +E+L+ + E L K
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 306 VGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEEL 365
+V E+ +Q E LQED +S A+ + + + L+ EE
Sbjct: 1108 NALKVVRELQAQIAE------------LQEDFESEKASRNKAEKQKRDLS------EELE 1149
Query: 366 TRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEK 425
K + D+L+ T Q L + ++V L L+ + H ++ ++ + A+ E+
Sbjct: 1150 ALKTELEDTLDT--TAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEE 1207
Query: 426 VTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLV 485
++ Q ++ + +L+ +E + K L E+ Q+ + + + + Q++ +
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDN---KELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 486 VNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESC 545
VS K +L +++ L A +K G+ + +++
Sbjct: 1265 HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKK-----GI--------KFAKDAA 1311
Query: 546 PLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQ 602
L + D Q+L +E R L R +++E +EQ E E R+ L K
Sbjct: 1312 SLESQLQDT----QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 603 QLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVE 662
L+ +L T++ + +E + +++ ++A +L Q L ++ Y +K+ + +
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY-----DKLEKTK 1422
Query: 663 TRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEE 718
RL+++L D L+ R+ + ++ + A+EK S +E R + EAR++E
Sbjct: 1423 NRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKE 1482
Query: 719 GQ--RLARRLQE 728
+ LAR L+E
Sbjct: 1483 TKALSLARALEE 1494
Score = 87.4 bits (215), Expect = 5e-17
Identities = 137/676 (20%), Positives = 286/676 (42%), Gaps = 78/676 (11%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 194
E +L +Q E + + + LE++V L+ K +++ +E+L A+K
Sbjct: 1343 EEKNSLQEQQE---EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399
Query: 195 EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSK 249
+AE L L + LE+ R +E+ L HQ Q++S + ++ L ++
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE 1459
Query: 250 AEGLEKSLSSLETRRAGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
+ + + R EA+E LA A EA +++ + + L A + + +
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519
Query: 303 RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 362
+ VG+ V L++ + +L E ++ +++ L L E
Sbjct: 1520 KDDVGKNV--------------------HELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 363 EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 422
+ R +++ +F R Q+ + EK L+ Q++ E E D KQ VAS
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK 1619
Query: 423 QEKVTSQSQEQAILQRSLQDKAAEVEVERMGA-----KGLQLELSRAQEARRRWQQQTAS 477
++ +A ++ + +KA + ++++ K Q EL A+ +R Q+
Sbjct: 1620 KKMEIDLKDLEAQIEAA--NKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677
Query: 478 AEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIA---RK 534
+E++L+ ++ + + L+ +A E A + L+ + + + + R+
Sbjct: 1678 SEKKLK----SLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733
Query: 535 LA--LAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 592
L +AQL +E L +++ L + R+ ++D L+A L + A ++ +
Sbjct: 1734 LEARIAQLEEE---LEEEQSNMELLNDRFRKTTLQVDT---LNAELAAER--SAAQKSDN 1785
Query: 593 ERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQ 652
RQQL + ++L+ +LQ+ + ++ S A + + EE L QE ++
Sbjct: 1786 ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE--QLEQEAKERA----- 1838
Query: 653 ALQEKVAEVETRLRE---QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQEL-- 707
A + V E +L+E Q+ D R ++ + + KA ++Q++R+ + +E +
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA 1898
Query: 708 --RRLQEEA--RKEEGQRLARRLQELE---RDKNLMLATLQQEGLLSRYKQQRLLTVLPS 760
R+LQ E E + L+R + L+ R + + + G + + L +
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDD 1958
Query: 761 LLDKKKSVVSSPRPPE 776
+ K S V+ +PP+
Sbjct: 1959 DTESKTSDVNETQPPQ 1974
Score = 79.3 bits (194), Expect = 1e-14
Identities = 93/443 (20%), Positives = 200/443 (45%), Gaps = 37/443 (8%)
Query: 100 SERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQ-ALSQQAEVIVRQLQELRRLE 158
++ + Q Q+ D+ S + + G+ LE S+ AL QQ E + QL+EL E
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGKNVHE--LEKSKRALEQQVEEMRTQLEEL---E 1552
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARA-----EKAGRAEAEGLRAALAGAEVVRKN- 212
+E++ + L+ ++ ++A + E + E+ R + +R A E RK
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR 1612
Query: 213 -LEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKEL 271
L S++++E + + Q+ + +A +E + L ++ LE RA +
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672
Query: 272 A---EAQREAELLRKQLSKTQEDLEAQVTL---VENLRKYVGEQVPSEVHSQTWELERQK 325
A E++++ + L ++ + QE+L + E R + +++ + ++ L+ ++
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKR 1732
Query: 326 LLET-MQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRK---VQPSDSLEPEFTR 381
LE + L+E+ + + ELL R + T + EL + Q SD+ + R
Sbjct: 1733 RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLER 1792
Query: 382 KCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAIL----- 436
+ + L + +E A+ + KA ++ L+ ++ L+E++ +++E+A
Sbjct: 1793 QNKELKAKLQELEGAVKSKFKA-------TISALEAKIGQLEEQLEQEAKERAAANKLVR 1845
Query: 437 --QRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQI 494
++ L++ +VE ER A + ++ +A ++ ++Q AEE+ + Q
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905
Query: 495 WLETTMAKVEGAAAQLPSLNNRL 517
L+ EG + ++ +L NRL
Sbjct: 1906 ELDDATEANEGLSREVSTLKNRL 1928
Score = 78.6 bits (192), Expect = 2e-14
Identities = 93/448 (20%), Positives = 194/448 (43%), Gaps = 23/448 (5%)
Query: 280 LLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDS 339
L RK +K Q+ L A L N Y+ + H Q W + K+ +Q +++ +
Sbjct: 801 LARKAFAKKQQQLSALKVLQRNCAAYLKLR-----HWQWWRVFT-KVKPLLQVTRQEEEL 854
Query: 340 LHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMV 399
ELL+V+ + + + EE+ RK Q + + Q+ + E +
Sbjct: 855 QAKDEELLKVKEKQTK--VEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE-EMRA 911
Query: 400 QLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQL 459
+L A++ E + + L+ +V +E+ E+ +Q +QD +++ E + LQL
Sbjct: 912 RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL 971
Query: 460 ELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWL---ETTMAKVEGAAAQLPSLNNR 516
E A+ ++ +++ E+Q + + + + +A+ E A L + N+
Sbjct: 972 EKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNK 1031
Query: 517 LSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSA 576
+ + L + +L + L TD+ ++ +L+ + + L +L
Sbjct: 1032 QEVMISDLE--ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE 1089
Query: 577 RLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEA 636
+Q + R ++ + KV ++L+ ++ + QE S A + +++ +EE
Sbjct: 1090 EELQGALARGDDE-TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL 1148
Query: 637 ASLRQEL-------TQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVS 689
+L+ EL QQEL + QE VAE++ L E+ + E ++ + R+ HA A+
Sbjct: 1149 EALKTELEDTLDTTAAQQELRTKREQE-VAELKKALEEETKNHEAQIQDMRQRHATALEE 1207
Query: 690 LRQIQRRAAQEKERSQELRRLQEEARKE 717
L + +A + K ++ ++ E KE
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Score = 43.5 bits (101), Expect = 8e-04
Identities = 45/203 (22%), Positives = 93/203 (45%), Gaps = 11/203 (5%)
Query: 556 LELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESL 615
L++ + EE D EL L + Q +V E+ E + QQL + L ++LQ E
Sbjct: 845 LQVTRQEEELQAKDEEL-LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 616 ASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR---LREQLSDT 672
A ++ +++ EE + +++E Q LQ + +++ L EQL +
Sbjct: 904 AEAE-EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 673 ERRLNEARREHAKAVVSLRQIQRRAAQEKERSQEL---RRLQEEARKEEGQRLARRLQEL 729
E + + E A +++++ ++++ + ++L E+ E +LA +E
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA---EEE 1019
Query: 730 ERDKNLMLATLQQEGLLSRYKQQ 752
E+ KNL +QE ++S +++
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEER 1042
Score = 34.3 bits (77), Expect = 0.49
Identities = 32/144 (22%), Positives = 66/144 (45%), Gaps = 10/144 (6%)
Query: 687 VVSLRQIQRRAAQEKERSQELRRLQEEARKEEG--QRLARRLQELERDKNLMLATLQQEG 744
V L Q+ R+ + + + +EL +++E+ K EG + + R+ Q+L +KN++ LQ E
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 745 LLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDL 804
L ++ + L KK+ + E + V + ++ + +
Sbjct: 901 ELFAEAEE----MRARLAAKKQELEEILHDLE----SRVEEEEERNQILQNEKKKMQAHI 952
Query: 805 QDLSEAISKEEAVCQGDNLDRCSS 828
QDL E + +EE Q L++ ++
Sbjct: 953 QDLEEQLDEEEGARQKLQLEKVTA 976
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 107 bits (266), Expect = 6e-23
Identities = 164/708 (23%), Positives = 310/708 (43%), Gaps = 90/708 (12%)
Query: 145 EVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALA 204
EV Q L+ LE + LLR+ Q ++ + + ++ +G EA +R L
Sbjct: 848 EVYAINRQRLQNLEFALNLLRQ---QPEVEVTHETLQ----RNRPDSGVEEAWKIRKELD 900
Query: 205 GAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 264
R+ LE + EE+ L + Q + +E L + LE+S L+
Sbjct: 901 EETERRRQLENEVKSTQEEIWTL-RNQGPQESVVRKEVLKKVPDPV--LEESFQQLQ--- 954
Query: 265 AGEAKELAEAQREAELLRKQLSKTQEDLEA-QVTLVENLRKYVGEQVPSEVHSQTWELER 323
+ LAE Q + +LL+++L Q L A + + ++YV ++V + E
Sbjct: 955 ----RTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEV 1010
Query: 324 QKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC 383
+L E ++ L+ + + A LLQ RV +L + +E++T K +P+ +
Sbjct: 1011 LQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEY 1070
Query: 384 QSLLNRWREKVFALMVQLKAQELEH----SDSVKQLKGQVASLQEKVTSQS----QEQAI 435
Q L + + QL+ ++ E D +K+L+ + A + K+T + ++ A
Sbjct: 1071 QQLQEDHQRQD-----QLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAA 1125
Query: 436 LQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASA----EEQLRLVV----- 486
+R + D + E E A+ Q E + + R+ W + +A +E++R +V
Sbjct: 1126 TEREVSDLTRQYEDEAAKARASQRE--KTELLRKIWALEEENAKVVVQEKVREIVRPDPK 1183
Query: 487 --NAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQES 544
+ V++ ++ L K GA QL S + L R+ + +++ ++ ++
Sbjct: 1184 AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVE---VKEVTKEVIKYKT 1240
Query: 545 CPLPPPVTDVSLELQQLREE---RNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVA 601
P ++ ELQ+LREE + RL L +++E+ ++ + Q +V
Sbjct: 1241 DP------EMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDT--KPQVQTKEVV 1292
Query: 602 QQLEQ--ELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQE----LYGQALQ 655
Q++ Q E QT+E +ASL +L ++ Q + E AS +++ +++E + + +Q
Sbjct: 1293 QEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQ 1352
Query: 656 EKVA--EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEE 713
++V E E LR + S ++ R+ K LR++QRR + + + +EL R E
Sbjct: 1353 QEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELER--ER 1410
Query: 714 ARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPR 773
+ E +R +RLQ+ LA L+QE +R K + + VV
Sbjct: 1411 QARREAEREVQRLQQ-------RLAALEQEEAEAREK-----------VTHTQKVVLQQD 1452
Query: 774 PPECSASAPVAAAVP----TRESIKGSLSVLLDDLQDLSEAISKEEAV 817
P + A + + R+ ++G L L L L +A KE+ V
Sbjct: 1453 PQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV 1500
Score = 87.8 bits (216), Expect = 4e-17
Identities = 162/699 (23%), Positives = 301/699 (43%), Gaps = 116/699 (16%)
Query: 150 QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE--ALARAEKAGRAEAEGLRAALAGAE 207
Q E+ +L EE+ LR +QK EA+ + L+ A AE+ RA+ + + E
Sbjct: 1006 QADEVLQLREELEALR----RQKGAREAEVLLLQQRVAALAEEKSRAQEK-----VTEKE 1056
Query: 208 VVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE 267
VV+ + + E +++Q HQ Q L + EE LS L K + LEK
Sbjct: 1057 VVKLQNDPQLEAEYQQLQEDHQRQ-DQLREKQEEELSFLQDKLKRLEKE----------- 1104
Query: 268 AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLL 327
A E ++ K++ K ++D + + + R+Y E + + E+ +LL
Sbjct: 1105 -----RAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQR----EKTELL 1155
Query: 328 ETMQHLQEDRDSLHATAELLQV-----RVQSLTHILALQEEELTRKVQPSDSLEPEFTRK 382
+ L+E+ + ++ ++ + +S L L+ E RK + ++ E R
Sbjct: 1156 RKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAE----EQLRS 1211
Query: 383 CQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR-SLQ 441
QS L R + + V+ +E+ + +++ ++ L+E++ +++ +++R L+
Sbjct: 1212 YQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR---LIERCDLE 1268
Query: 442 DKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEE--QLRLVVNAVSSSQIWLETT 499
+ E++ + Q++ + ++Q+ + EE LR ++ Q+ LE
Sbjct: 1269 IYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERE 1328
Query: 500 MAKVEGAAAQLPSLNNRLSYAVRKVHTIR-----GLIARKLALAQLRQESCPLPPPVTDV 554
A E A+ +R+ V + +R GL A A A+ +
Sbjct: 1329 RASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAE-------------SI 1375
Query: 555 SLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQES 614
+EL+Q+ ++L AEL+ R + E+ R E+ E ERQ ++ E+E+Q+ Q+
Sbjct: 1376 DVELRQI----DKLRAELRRLQRR-RTELERQLEELERERQ----ARREAEREVQRLQQR 1426
Query: 615 LASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTER 674
LA+L +E A R+++T Q++ Q ++ E LR QL + +
Sbjct: 1427 LAAL--------------EQEEAEAREKVTHTQKVVLQQDPQQARE-HALLRLQLEEEQH 1471
Query: 675 R-------LNEARREHA---KAVVSLRQIQRRAAQ--EKERSQELRR----LQEEARKE- 717
R L RR+ A KA V + + + Q + + QE++R L+EE+R +
Sbjct: 1472 RRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKR 1531
Query: 718 ----EGQRLARRLQELE---RDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVS 770
E RL RL ELE + L L++E + ++Q L L + +
Sbjct: 1532 ELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAAT 1591
Query: 771 SPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSE 809
R + VA + +S SL LDDL+ LS+
Sbjct: 1592 ETRD---LRNMTVADSGTNHDSRLWSLERELDDLKRLSK 1627
Score = 62.4 bits (150), Expect = 2e-09
Identities = 105/525 (20%), Positives = 222/525 (42%), Gaps = 42/525 (8%)
Query: 119 SSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQ 178
+S R++ + W LE A E + ++ + E EV LR ++Q+ +
Sbjct: 1146 ASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGA 1205
Query: 179 AMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQE--QLSSLT 236
+L + +A R + EV++ + ++EL QRL +E + L
Sbjct: 1206 EEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKEL---QRLREEIVDKTRLI 1262
Query: 237 QAHEEALSSLTSKAEGLEKSLSSLETRR-AGEAKELAEAQREAELLRKQLSKTQEDLEAQ 295
+ + + L + + L+ + ++T+ E + E + E + +K E+ + Q
Sbjct: 1263 ERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQ 1322
Query: 296 VTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQED--RDSLHATAELLQVRVQS 353
V L E R EQ+ + + ER E +++ +E R A AE + V ++
Sbjct: 1323 VDL-ERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQ 1381
Query: 354 LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK 413
+ + A R+ + LE E R+ Q+ RE V L +L A E E +++ +
Sbjct: 1382 IDKLRAELRRLQRRRTELERQLE-ELERERQARREAERE-VQRLQQRLAALEQEEAEARE 1439
Query: 414 QLKGQVASLQEKVTSQSQEQAILQRSLQD-----KAAEVEVERMGAKGLQLELSRAQE-- 466
++ + ++ Q++E A+L+ L++ + E E+E + K LE + +E
Sbjct: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499
Query: 467 -ARRRWQQQTASAEEQLRLVVNAV---SSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVR 522
Q + E++++ + +++ S S+ L+ ++++E ++L N++ S
Sbjct: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSS---- 1555
Query: 523 KVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQE 582
L LR+E+ L ++ LE ++L+ E N E + + +
Sbjct: 1556 ------------KELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVAD 1603
Query: 583 VGRAREQG----EAERQQLSKVAQQLEQELQQTQESLASLGLQLE 623
G + E E L ++++ + E+ + Q+ L S+ ++ E
Sbjct: 1604 SGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKRE 1648
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 106 bits (265), Expect = 8e-23
Identities = 195/826 (23%), Positives = 341/826 (41%), Gaps = 151/826 (18%)
Query: 97 QDVSERRLDTQ------RPQVTMWERDVSSDRQEPGR-RGRSWGLEGSQALSQQAEVIVR 149
Q + ER DT+ ++ +R +S +++E + G+ LE L + E +
Sbjct: 1267 QKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESE--LMELHETMAS 1324
Query: 150 QLQELRRLE---EEVRLLRETSLQQKMRLEAQAMEL-----EALARAEKAGRAEAEGLRA 201
LRR E E + RE K L AQ L EA A+A AG E E LR
Sbjct: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILE-EDLRT 1383
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLE 261
A + ++ KN E S+RE + + E + +A +E L+ LT E+ + +L
Sbjct: 1384 ARSALKL--KNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 262 TRRAGEAKELAEAQREA-----ELLRKQLSKTQEDLEAQVTLVENLRKY--VGEQVPSEV 314
G+ +EL E QRE ELL L K ++++ Q ++ L K V E +P V
Sbjct: 1442 ----GQIQEL-EKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496
Query: 315 HSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE---EELTRKVQP 371
+ +L Q+ E ++ L++DR++ E + ++ ++ Q ++L +++
Sbjct: 1497 QEREQKLTVQR--EQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVT 1554
Query: 372 SDSLEPEFTR-----KCQSLLNR----WREKVFALMVQLKAQELEHSDSVKQLKGQVASL 422
+ L E +CQ L + RE + L E S ++ Q+ L
Sbjct: 1555 LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDL 1614
Query: 423 QEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQL 482
+ T +L R LQ++ EV+ +R + LQ + + R Q+ +E++
Sbjct: 1615 ESHST-------VLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERI 1667
Query: 483 RLVVNAVSSSQIWLETTMAKVEGA--------AAQLPSLNNRLSYAVRKVHTIRGLIAR- 533
+++ + + LE + +++ + Q + R RG +
Sbjct: 1668 QVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHM 1727
Query: 534 KLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQ------------LSAR---- 577
KL L +E V + +L+E +++L+ +LQ LS R
Sbjct: 1728 KLILRDKEKE-------VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
Query: 578 -LIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVAR------QGQQ 630
++QQ++ AREQGE + Q L + +L + Q +LA +LE + QGQ+
Sbjct: 1781 VVLQQQLQEAREQGELKEQSL-------QSQLDEAQRALAQRDQELEALQQEQQQAQGQE 1833
Query: 631 ESTEEAASLRQELTQQ-----QELYGQALQEKVAEVETRLREQLSDTERR---------- 675
E +E A Q +Q +E +G+ K E RL E+L+ RR
Sbjct: 1834 ERVKEKADALQGALEQAHMTLKERHGELQDHK--EQARRLEEELAVEGRRVQALEEVLGD 1891
Query: 676 LNEARREHAKAVVSLRQ----------IQRRAAQE---------KERSQELRRLQEEARK 716
L RE KA+++L+Q ++ RA Q+ KER QEL L+ E++
Sbjct: 1892 LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Query: 717 EEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPE 776
Q A R + + L A +G K+Q LL + +S+ +S +
Sbjct: 1952 SRHQEEAARARAEALQEALGKAHAALQG-----KEQHLL----EQAELSRSLEASTATLQ 2002
Query: 777 CSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSEAISKEE 815
S A A + E+++ + D D+Q L +A+++ +
Sbjct: 2003 ASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRD 2048
Score = 106 bits (265), Expect = 8e-23
Identities = 177/711 (24%), Positives = 315/711 (44%), Gaps = 97/711 (13%)
Query: 101 ERRLDTQRPQVTMWERDVSSDRQEPG-RRGRSWGLEGSQALSQQAEVIVRQL-QELRRLE 158
E++ + Q+ + + D+ QE ++ + LE +++ + + V++ Q+L
Sbjct: 1448 EKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQR 1507
Query: 159 EEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQ 218
E++R L + Q+ LE Q +ELE + ++ R + + L+ L E + LEE +
Sbjct: 1508 EQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEE-NH 1566
Query: 219 RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSS-------LETRRAGEAKEL 271
++E Q+L +E L + AL+ LT E + L + LE+ A+EL
Sbjct: 1567 HKMECQQKLIKE-LEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL 1625
Query: 272 AEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
E +E + R+Q+ + Q E L ++L + E + + Q LE Q+ +T +
Sbjct: 1626 QERDQEVKSQREQIEELQRQKEH---LTQDLERRDQELMLQKERIQV--LEDQRTRQT-K 1679
Query: 332 HLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWR 391
L+ED + + + L+ R + LT L +E PS + L+ R +
Sbjct: 1680 ILEEDLEQIKLS---LRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH--MKLILRDK 1734
Query: 392 EKVFALMVQLKAQELEHSDSVK-QLKGQVASLQEKV-------TSQSQEQAILQRSLQDK 443
EK V+ + + + +K QL+ Q+ L KV + + QE +LQ+ LQ+
Sbjct: 1735 EKE----VECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790
Query: 444 AAEVEVERMGAKGLQLELSRAQ----------EARRRWQQQTASAEEQLR----LVVNAV 489
+ E++ + LQ +L AQ EA ++ QQQ EE+++ + A+
Sbjct: 1791 REQGELKE---QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGAL 1847
Query: 490 SSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTI---------------RGLIARK 534
+ + L+ +++ Q L L+ R+V + + L+A +
Sbjct: 1848 EQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ 1907
Query: 535 LALAQLRQESCPLPPPVTDVSLELQQLREERNR----LDAELQLSARLIQQEVGRAREQ- 589
A+ QE + D L+ Q + +ER++ L AE Q S Q+E RAR +
Sbjct: 1908 QQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH--QEEAARARAEA 1965
Query: 590 -----GEAERQQLSKVAQQLEQ-ELQQTQE-SLASLGLQLEVARQGQQESTEEAASLRQE 642
G+A K LEQ EL ++ E S A+L L+ A Q EEA +++
Sbjct: 1966 LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLD-ACQAHSRQLEEALRIQEG 2024
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
Q Q+L QE V +++ L ++ D E R + R + + ++ R +Q QEK+
Sbjct: 2025 EIQDQDL---RYQEDVQQLQQALAQR--DEELRHQQEREQLLEKSLAQR-VQENMIQEKQ 2078
Query: 703 RSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQR 753
L +E +EE + L + ++EL+ L LA +QE L R QQR
Sbjct: 2079 N------LGQEREEEEIRGLHQSVRELQ----LTLAQKEQEILELRETQQR 2119
Score = 106 bits (264), Expect = 1e-22
Identities = 182/750 (24%), Positives = 318/750 (42%), Gaps = 104/750 (13%)
Query: 118 VSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEA 177
V + +EP GR G E +Q L A+ + + R +E ++L + L+ K L+
Sbjct: 225 VGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLE-KAELQD 283
Query: 178 QAMELEAL-ARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLT 236
+ EL AL +++K + ++A E++ N E + E + R QE+ SL
Sbjct: 284 RVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEAS-LSRNAQEEKLSLQ 342
Query: 237 QAHEEALSSLTSKAEGLEKSL---SSLETRRAGEAK-ELAEAQREAELLRKQLSKTQE-- 290
Q ++ + + + + + +SLE + ++ + +A + L+R L++ ++
Sbjct: 343 QVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAV 402
Query: 291 -DLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQV 349
DL Q+ + + +Q H Q WE E + L + +Q L +RD+L LQ
Sbjct: 403 QDLRQQLAGCQEAVNLLQQQ-----HDQ-WEEEGKALRQRLQKLTGERDTLAGQTVDLQG 456
Query: 350 RVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHS 409
V SL+ +E EL +K + + E + WR + + +QL+ +
Sbjct: 457 EVDSLS-----KERELLQKAREELRQQLEVLEQ-----EAWRLRRVNVELQLQGDSAQ-- 504
Query: 410 DSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQ--LELSRAQ-E 466
GQ QE++ +E+ LQ L A+ L+ LE S + E
Sbjct: 505 -------GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGE 557
Query: 467 ARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHT 526
R+ Q + +A + + +SSS+ L+T +A + AA +L +LN L A+ KV
Sbjct: 558 LLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL--ALDKV-- 613
Query: 527 IRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRA 586
GL + L L + Q C ++ + RN L +L A ++ +
Sbjct: 614 --GLNQQLLQLEEENQSVCS----------RMEAAEQARNALQVDLA-EAEKRREALWEK 660
Query: 587 REQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQ 646
EA+ Q+ + +L+ +L+ QE + +L +R Q+ +T + L QE +Q
Sbjct: 661 NTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ 720
Query: 647 QELYGQALQEKVAEV------ETRL------REQLSD-----------TERRLNEARREH 683
+E+ +A+QEK A V E RL R+ L++ E L EA++++
Sbjct: 721 EEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQN 780
Query: 684 AKAVVSLRQIQ---RRAAQEKERSQ-ELRRLQEEARKEEGQRLARRLQELERDKNL-MLA 738
+ V+ Q++ + Q KE Q E+R L+ E E Q E ERD LA
Sbjct: 781 SVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ------AEQERDAAARQLA 834
Query: 739 TLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLS 798
+QEG + +Q+ + L +K S E +A A+ + E K L
Sbjct: 835 QAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQE------LAKALESLEREKMELE 888
Query: 799 VLLDDLQDLSEAI---------SKEEAVCQ 819
+ L + Q EAI E A+CQ
Sbjct: 889 MRLKEQQTEMEAIQAQREEERTQAESALCQ 918
Score = 103 bits (256), Expect = 9e-22
Identities = 144/628 (22%), Positives = 269/628 (42%), Gaps = 59/628 (9%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAM-----ELEALARAE 189
E S LSQ+ + IV Q+L+ E+ L +E SLQ ++ +A+ ELEAL + +
Sbjct: 1768 ETSLLLSQREQEIVVLQQQLQEAREQGEL-KEQSLQSQLDEAQRALAQRDQELEALQQEQ 1826
Query: 190 KAGRAE-------AEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQL--SSLTQAHE 240
+ + + A+ L+ AL A + K Q E+ +RL +E QA E
Sbjct: 1827 QQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE 1886
Query: 241 EALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVE 300
E L L +++ EK+L +L+ ++ AE +E E+ + L + L+AQ L E
Sbjct: 1887 EVLGDLRAESREQEKALLALQ-------QQCAEQAQEHEVETRALQDSW--LQAQAVLKE 1937
Query: 301 NLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILAL 360
++ + S+ E R + + LQE HA LQ + Q L L
Sbjct: 1938 RDQELEALRAESQSSRHQEEAARARA----EALQEALGKAHAA---LQGKEQHL-----L 1985
Query: 361 QEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVA 420
++ EL+R ++ S + CQ+ + E + +++ Q+L + + V+QL+ +A
Sbjct: 1986 EQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALA 2045
Query: 421 SLQEKVTSQSQEQAILQRSLQDKAAE---VEVERMGAKGLQLELSRAQEARRRWQQQTAS 477
E++ Q + + +L++SL + E E + +G + + E+ ++ R Q A
Sbjct: 2046 QRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQ 2105
Query: 478 AEE---QLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH-TIRGLIAR 533
E+ +LR + + + +E + +L SL RL + ++ +R AR
Sbjct: 2106 KEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAR 2165
Query: 534 K-----------LALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQE 582
+ L+LAQ + L + + + E+ RL EL+L+ R +++E
Sbjct: 2166 EIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225
Query: 583 VGRAREQGEAERQQLSKVAQQLEQ--ELQQTQESLASLGLQLEVARQGQQESTEEAASLR 640
R G +L +Q Q E+ + + G++ + RQ + + A L
Sbjct: 2226 --RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLE 2283
Query: 641 QELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQE 700
+ ++ Q + L+ + +VE R+ + R E +KA S Q Q+
Sbjct: 2284 IDRSRLQR-HNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQK 2342
Query: 701 KERSQELRRLQEEARKEEGQRLARRLQE 728
++ + LQ+E + Q R Q+
Sbjct: 2343 NSDAKCVAELQKEVVLLQAQLTLERKQK 2370
Score = 95.5 bits (236), Expect = 2e-19
Identities = 166/743 (22%), Positives = 320/743 (43%), Gaps = 95/743 (12%)
Query: 116 RDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRL 175
RD+ +++E ++ L S+ + A + QL + + +EEV L R ++Q+K L
Sbjct: 683 RDIQEEKEEIQKK-----LSESRHQQEAATTQLEQLHQEAKRQEEV-LAR--AVQEKEAL 734
Query: 176 EAQAMELEALARAEKAGRAE-AEGLRAALAGAEVVRKNLEEGSQRE--LEEVQRLHQEQL 232
+ LE +A + R + AE L+ + E++ +L E Q+ +E + + Q+
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794
Query: 233 SSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAEL-LRKQLSKTQED 291
++TQA E + L+ S E R A++LA+A++E + L +Q + +++
Sbjct: 795 QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKE 854
Query: 292 LEAQVTLVENLRKYVGEQVPSEVHS---QTWELE-----RQKLLETMQHLQEDRDSLHAT 343
+ E R + +++ + S + ELE +Q +E +Q Q + + A
Sbjct: 855 VNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ-AQREEERTQAE 913
Query: 344 AELLQVRVQ------SLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFAL 397
+ L Q++++ SL L ++EL Q + L + K Q L + +E L
Sbjct: 914 SALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM--KVQKL--KEQETTGIL 969
Query: 398 MVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEV----EVERMG 453
QL+ + E ++ +Q + +A+LQE+ +S Q++ LQ+ ++D +++ + +R+
Sbjct: 970 QTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLV 1029
Query: 454 AKGLQLELSRAQEARR---RWQQQTASA-------EEQLRLVVNAVSSSQIWLETTMAKV 503
+ +Q +L QE R +++ AS E++L ++ A S Q L +
Sbjct: 1030 EQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDM 1089
Query: 504 EGAAAQLPSLNNRLSYAVRKVHTIRG-LIARKLALAQLRQESCPLPPPVTDVSLELQQLR 562
+ A + L+ ++ ++V +A++ L + + S +T+ L
Sbjct: 1090 QEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS-----HITEQQLRASLWA 1144
Query: 563 EERNRLDAELQLSARLIQQEVGRAREQ--GEAERQ-QLSKVAQQLEQELQQTQESLASLG 619
+E +L+L + Q E A +Q +A+ Q QL+ + L+Q L ES L
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELS 1204
Query: 620 ---------LQLEVARQGQQE-----------STEEAASLRQELTQQQELYGQALQEKVA 659
LE + G + S E AS +L Q+L+ K
Sbjct: 1205 GGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKL--HQDLW------KTQ 1256
Query: 660 EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 719
+ LR+Q+ E RL + E ++ L+ +QR+ +Q QEE K EG
Sbjct: 1257 QTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQN----------QEEKSKWEG 1306
Query: 720 QR--LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPEC 777
++ L L EL + + L++ L R + Q +L + + + V +
Sbjct: 1307 KQNSLESELMELHETMASLQSRLRR-AELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
Query: 778 SASAPVAAAVPTRESIKGSLSVL 800
A A +AA E ++ + S L
Sbjct: 1366 EARAQASAAGILEEDLRTARSAL 1388
Score = 89.7 bits (221), Expect = 1e-17
Identities = 153/721 (21%), Positives = 295/721 (40%), Gaps = 130/721 (18%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 194
+ +AL+ V+ R+ Q ++ L +++ +E L+ Q + E +A +
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV----NLLQQQHDQWEEEGKALRQRLQ 438
Query: 195 EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLE 254
+ G R LAG V + + +E E +Q+ +E L +EA E L+
Sbjct: 439 KLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVE-LQ 497
Query: 255 KSLSSLETRRAGEAKELAEAQREAELLRKQL----SKTQEDLEAQVTLVENLRK--YVGE 308
S + ++ + +EL A RE E L++ L +K E L +TL E L GE
Sbjct: 498 LQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGE 557
Query: 309 QVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ---VRVQSLTHILALQEEEL 365
+ E T L R + +++ L ++L L+ V++ +L LAL + L
Sbjct: 558 LLRQEQTEVTAALARAE--QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGL 615
Query: 366 TRKVQPSDSLEPEFTRKCQSL----------------LNRWREKVFALMVQLKAQELEHS 409
+++ LE E C + + RE ++ L+AQ +
Sbjct: 616 NQQLL---QLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAE 672
Query: 410 DSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE--LSRAQEA 467
++ +L+ + +QE+ + ++ + + Q +AA ++E++ + + E L+RA +
Sbjct: 673 EAGAELQADLRDIQEE--KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
Query: 468 RRRWQQQTASAEEQLRLV----------VNAVSSSQIWLETTMAKVEGAAAQLPSLNNRL 517
+ ++ A+ E +L+ V + +SS++ LE+++ + + + + +L
Sbjct: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
Query: 518 SYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRL-----DAEL 572
++ V + +I ++ +L ++ E Q +ER+ AE
Sbjct: 791 EVQIQTVTQAKEVIQGEVRCLKL------------ELDTERSQAEQERDAAARQLAQAEQ 838
Query: 573 QLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQ-- 630
+ L QQ+ +E + R++ K +QEL + ESL ++LE+ + QQ
Sbjct: 839 EGKTALEQQKAAHEKEVNQL-REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTE 897
Query: 631 ------------------------ESTEEAASLRQELTQQQELYGQALQ----------- 655
E+ +E SL + L Q Q+ A Q
Sbjct: 898 MEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKV 957
Query: 656 EKVAEVETR--LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK------------ 701
+K+ E ET L+ QL + +R L EA R+H + +L++ Q+K
Sbjct: 958 QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKS 1017
Query: 702 -----ERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLT 756
+ SQ L + + + E Q R +ELER+K + +L + K+QRLL
Sbjct: 1018 QLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME-------KEQRLLV 1070
Query: 757 V 757
+
Sbjct: 1071 L 1071
Score = 38.1 bits (87), Expect = 0.034
Identities = 43/184 (23%), Positives = 79/184 (42%), Gaps = 27/184 (14%)
Query: 139 ALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEK-------- 190
A+ QA V+ R E +RL++E+ L R ++++ E +R E+
Sbjct: 2194 AMFLQASVLERD-SEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVS 2252
Query: 191 --------------AGRAEAEGLRAALAGAEVVRKNLEEGS---QRELEEVQRLHQEQLS 233
+ R E L+ A+A E+ R L+ + + LE+V+R + +L
Sbjct: 2253 GVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVER-ERRKLK 2311
Query: 234 SLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLE 293
+A S SKA + ++ +AK +AE Q+E LL+ QL+ ++ +
Sbjct: 2312 REAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQ 2371
Query: 294 AQVT 297
+T
Sbjct: 2372 DYIT 2375
Score = 33.5 bits (75), Expect = 0.84
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 37/208 (17%)
Query: 593 ERQQLSKVAQQLEQELQQTQESLASLGLQLEV-----------ARQGQQESTEEAASLRQ 641
E L ++ +LE+E QQ ESLA + QL + R+ ++ T + + R
Sbjct: 92 EEPNLDELLVRLEEE-QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARD 150
Query: 642 ELTQQQE------------LYGQ-----ALQEKVAEVETRLREQLSDTERRLNEARREHA 684
EL +++ L G+ +L +V E S T+R L E + EH
Sbjct: 151 ELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHV 210
Query: 685 KAVVSLRQIQRR---AAQEKERSQELRRLQEEARKEEGQRLARRLQELER---DKNLMLA 738
+ SL R AQ +E + R + + L + QELE+ +++ L
Sbjct: 211 RLSGSLLTCCLRLTVGAQSREPNGSGR--MDGREPAQLLLLLAKTQELEKEAHERSQELI 268
Query: 739 TLQQEGLLSRYKQQRLLTVLPSLLDKKK 766
L+ +G L + + Q +T L +LL + +
Sbjct: 269 QLKSQGDLEKAELQDRVTELSALLTQSQ 296
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 106 bits (264), Expect = 1e-22
Identities = 171/721 (23%), Positives = 298/721 (41%), Gaps = 105/721 (14%)
Query: 139 ALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG 198
A Q+ E++V +L+ EEE +T +K RL+ ELEA AE+ R +
Sbjct: 940 ARKQELELVVSELEARVGEEEECSRQMQT---EKKRLQQHIQELEAHLEAEEGARQK--- 993
Query: 199 LRAALAGAEVVRKNLEEG------SQRELEEVQRLHQEQL---SSLTQAHEEALSSLTS- 248
L+ E K EE +L + ++L +++L SS EE + SL
Sbjct: 994 LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKL 1053
Query: 249 ----------------KAEGLEKSLSSLETRRAGEAKEL----AEAQREAELLRKQLSKT 288
K E + L L+ R GE+ EL E Q+ AE LR QL +
Sbjct: 1054 RLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRK 1113
Query: 289 QEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ 348
+E+L+A + E+ + + S +Q L E + L+ +R + +
Sbjct: 1114 EEELQAALARAEDEGGARAQLLKSLREAQA------ALAEAQEDLESER--------VAR 1159
Query: 349 VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 408
+ + L + E L +++ D+L+ T Q L ++ ++V L L+ + H
Sbjct: 1160 TKAEKQRRDLGEELEALRGELE--DTLDS--TNAQQELRSKREQEVTELKKTLEEETRIH 1215
Query: 409 SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDK---AAEVEVERMGAKGLQLELSRAQ 465
+V++L+ + ++ Q EQA + +K A E EV L+ ELS Q
Sbjct: 1216 EAAVQELRQRHGQALGELAEQ-LEQARRGKGAWEKTRLALEAEVSE-----LRAELSSLQ 1269
Query: 466 EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 525
AR+ +Q+ E QL+ V + K++ A A+L +++ L+ A K
Sbjct: 1270 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-- 1327
Query: 526 TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGR 585
TIR ++++L+ + + + Q+L +E R L R ++ E
Sbjct: 1328 TIR--LSKELSSTEAQLH-------------DAQELLQEETRAKLALGSRVRAMEAEAAG 1372
Query: 586 AREQGEAE---RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
REQ E E R++ + Q + +L + + LE + ++ + EA +L Q
Sbjct: 1373 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1432
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQ--E 700
L ++ E +++ RL+++L D L + R + V +L + QR+ Q
Sbjct: 1433 LAEKTETV-----DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLA 1483
Query: 701 KERSQELRRLQEEARKE-EGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTV-L 758
+E++ LR ++E R E EG+ R L R +QE +Q R L L
Sbjct: 1484 EEKAAVLRAVEERERAEAEGREREARALSLTR-----ALEEEQEAREELERQNRALRAEL 1538
Query: 759 PSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVC 818
+LL K V S E + AA ++ ++ L D+L +A + E
Sbjct: 1539 EALLSSKDDVGKSVHELERACRVAEQAA----NDLRAQVTELEDELTAAEDAKLRLEVTV 1594
Query: 819 Q 819
Q
Sbjct: 1595 Q 1595
Score = 97.4 bits (241), Expect = 5e-20
Identities = 160/684 (23%), Positives = 280/684 (40%), Gaps = 101/684 (14%)
Query: 154 LRRLEEE----VRLLRETSLQQKMRLEAQA-MELEALAR--AEKAGR---AEAEGLRAAL 203
L R E+E +LL+ Q EAQ +E E +AR AEK R E E LR L
Sbjct: 1121 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1180
Query: 204 --------AGAEVVRKNLEEGSQ--RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 253
A E+ K +E ++ + LEE R+H+ + L Q H +AL L + E
Sbjct: 1181 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1240
Query: 254 EKSLSSLE-TRRAGEAK---------ELAEAQREAELLRKQLSKTQEDLEAQVTLVENLR 303
+ + E TR A EA+ L A++E E R++L ++++ + E R
Sbjct: 1241 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1300
Query: 304 KYVGEQV---PSEVHSQTWELE--RQKLLETMQHLQEDRDSLHATAELLQ---------- 348
E++ +E+ + + L K + + L LH ELLQ
Sbjct: 1301 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1360
Query: 349 VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 408
RV+++ A E+L + + E + Q+ L+ WR + L+A E
Sbjct: 1361 SRVRAMEAEAAGLREQLEEEAAARERAGREL-QTAQAQLSEWRRRQEEEAGALEAGEEAR 1419
Query: 409 SDSVKQLKGQVASLQEK---VTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE----- 460
+ ++ + L EK V + + LQ+ L D ++E +R L+ +
Sbjct: 1420 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1479
Query: 461 ---------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
+ RA E R R + + E + + A+ Q E + A+L
Sbjct: 1480 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1539
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE 571
+L + + VH + + A Q + L VT++ EL + + RL+
Sbjct: 1540 ALLSSKDDVGKSVHEL------ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1593
Query: 572 LQLSARLIQQEVGRAREQGEAERQQLSKVAQ--QLEQELQQTQESLA------------S 617
+Q ++++ E GE R+QL+K + ++E++ ++ Q +LA
Sbjct: 1594 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1653
Query: 618 LGLQLEVARQGQQESTEEAASLRQEL-----------TQQQELYGQALQE----KVAEVE 662
L Q+ A QG++E+ ++ ++ ++ T ++E++ Q + K E E
Sbjct: 1654 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1713
Query: 663 T-RLREQL--SDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 719
RL+E+L SD RR + R+ V+ + + A E++R E R Q E EE
Sbjct: 1714 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1773
Query: 720 QRLARRLQELERDKNLMLATLQQE 743
Q + L + R L + +L E
Sbjct: 1774 QSNSELLNDRYRKLLLQVESLTTE 1797
Score = 93.6 bits (231), Expect = 7e-19
Identities = 176/707 (24%), Positives = 293/707 (41%), Gaps = 117/707 (16%)
Query: 120 SDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQA 179
+++ E RRG+ G L+ +AEV ELR ++ R+ Q++ RLE Q
Sbjct: 1234 AEQLEQARRGK--GAWEKTRLALEAEV-----SELRAELSSLQTARQEGEQRRRRLELQL 1286
Query: 180 MELEALARAEKAGRAE-AEGLRAALAGAEVVRKNLEEGS------QRELEEVQ-RLHQEQ 231
E++ A + RAE AE L+ A A E V L E +EL + +LH Q
Sbjct: 1287 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1346
Query: 232 LSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLS---KT 288
L Q A +L S+ +E + L + EA A RE + + QLS +
Sbjct: 1347 --ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1404
Query: 289 QEDLEAQVTLVENLRKYVGEQ------------------------VPSEVHSQTWELERQ 324
QE+ + E R+ + + E+ T +LE+Q
Sbjct: 1405 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1464
Query: 325 K-LLETMQHLQEDRDSLHA---TAELLQVRVQSLTHILALQEE----ELTRKVQPSDSLE 376
+ L+ T++ Q D L A A L V + + E LTR ++
Sbjct: 1465 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1524
Query: 377 PEFTRKCQSLLNRWREKVFALM-----VQLKAQELEHS-----DSVKQLKGQVASLQEKV 426
E R+ ++L R ++ AL+ V ELE + + L+ QV L++++
Sbjct: 1525 EELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1580
Query: 427 TSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAE------- 479
T + E A L+ + +A + + ER LQ +E RR+ +Q AE
Sbjct: 1581 T--AAEDAKLRLEVTVQALKTQHER----DLQGRDEAGEERRRQLAKQLRDAEVERDEER 1634
Query: 480 EQLRLVVNAVSSSQIWLETTMAKV-------EGAAAQLPSLNNRLSYAVRKVHTIRGLIA 532
+Q L V A + LE A++ E A QL + ++ R+V R +
Sbjct: 1635 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR--TS 1692
Query: 533 RKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 592
R+ +Q R+ L +V L LQ+ +R + Q + EV A
Sbjct: 1693 REEIFSQNRESEKRLKGLEAEV-LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1751
Query: 593 ---ERQQLSKVAQQLEQELQQTQESLASLG-------LQLE---VARQGQQESTEEAASL 639
E++QL QLE+EL++ Q + L LQ+E ++ + +A S
Sbjct: 1752 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1811
Query: 640 RQELTQQ-QELYGQALQEKVAEVETR-------LREQLSDTERRLNEARREHAKAVVSLR 691
RQ+L +Q QEL G+ L E+ A R L +L+ E +L + RE + +R
Sbjct: 1812 RQQLERQIQELRGR-LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1870
Query: 692 QIQRRAAQEKERSQELRRLQEEARK--EEG----QRLARRLQELERD 732
+ ++R + + +E RR+ ++ R E+G ++L R+L+E E +
Sbjct: 1871 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1917
Score = 90.9 bits (224), Expect = 4e-18
Identities = 145/582 (24%), Positives = 246/582 (42%), Gaps = 63/582 (10%)
Query: 257 LSSLETRRAGEAKELA---EAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 313
L+ LE R + ++ +A L R+ K Q+ A + N Y+ +
Sbjct: 800 LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLR---- 855
Query: 314 VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEE------ELTR 367
H Q W L K+ +Q ++D E+LQ R Q L + LQ++ EL
Sbjct: 856 -HWQWWRLFT-KVKPLLQVTRQD--------EVLQARAQELQKVQELQQQSAREVGELQG 905
Query: 368 KVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQ----LKAQELEHSDSVKQLKGQVASLQ 423
+V LE E R + L R ++ A + L A++ E V +L+ +V +
Sbjct: 906 RVA---QLEEERARLAEQL--RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEE 960
Query: 424 EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLR 483
E E+ LQ+ +Q+ A +E E + LQLE + +++++ E+Q
Sbjct: 961 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQ-- 1018
Query: 484 LVVNAVSSSQIWLETTMAKVEGAAAQ----LPSLNN-RLSYAVRKVHTIRGLIARKLALA 538
+ +S + LE +A+ AA+ + SLN RL Y TI + R
Sbjct: 1019 --NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEA----TIADMEDRLRKEE 1072
Query: 539 QLRQESCPLPPPVTDVSLELQ-QLREERNR---LDAELQLSARLIQQEVGRAREQGEAER 594
+ RQE L + S ELQ Q+ E++ R L A+L +Q + RA ++G A R
Sbjct: 1073 KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA-R 1131
Query: 595 QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL 654
QL K ++ + L + QE L S + A + +++ EE +LR EL + L
Sbjct: 1132 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL--EDTLDSTNA 1189
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 714
Q+ E+ ++ +++++ ++ L E R H AV LRQ +A E E R + A
Sbjct: 1190 QQ---ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1246
Query: 715 RKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRP 774
++ L + EL + + L T +QEG R + L L + +
Sbjct: 1247 WEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRR-------LELQLQEVQGRAGDGER 1298
Query: 775 PECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEA 816
A+ + A E++ G+L+ LS+ +S EA
Sbjct: 1299 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1340
Score = 84.0 bits (206), Expect = 5e-16
Identities = 130/592 (21%), Positives = 236/592 (39%), Gaps = 77/592 (13%)
Query: 102 RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQE----LRRL 157
R L T + Q++ W R RQE G E + +++AE + ++L E + RL
Sbjct: 1389 RELQTAQAQLSEWRR-----RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1443
Query: 158 EEEVRLLRETSLQQKMRLEAQAMELEALARAE-KAGRAEAEGLRAALAGAEVVRKNLEEG 216
E R L++ M LE Q + L + + K + AE A L E + EG
Sbjct: 1444 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1503
Query: 217 SQRE---------LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE 267
+RE LEE Q +E+L +A L +L S + + KS+ LE
Sbjct: 1504 REREARALSLTRALEEEQEA-REELERQNRALRAELEALLSSKDDVGKSVHELE------ 1556
Query: 268 AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWE 320
+ A++ A LR Q+++ +++L A LR V Q H + E
Sbjct: 1557 -RACRVAEQAANDLRAQVTELEDELTAAEDA--KLRLEVTVQALKTQHERDLQGRDEAGE 1613
Query: 321 LERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT 380
R++L + ++ + +RD L + L L + ++ Q + +
Sbjct: 1614 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLR 1673
Query: 381 RKCQSLLNRWRE--KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR 438
+ + WRE + ++ +Q E +K L+ +V LQE++ + + + Q+
Sbjct: 1674 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1733
Query: 439 SLQDKAAEVEVERMGAKGL-----QLE--LSRAQEARRRWQQQTASAEEQLRLVVNAVSS 491
+ A EV + + QLE L + +E Q + ++ R ++ V S
Sbjct: 1734 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVES 1793
Query: 492 SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 551
L T ++ +A+ S +L R++ +RG + + A A+ R + +
Sbjct: 1794 ----LTTELSAERSFSAKAESGRQQLE---RQIQELRGRLGEEDAGARARHKMT-----I 1841
Query: 552 TDVSLELQQLREERNRLDAELQLSARLIQQEVGRARE---QGEAERQ------------- 595
+ +L Q E+ + E LS +L+++ R +E Q E ER+
Sbjct: 1842 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1901
Query: 596 ----QLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQEL 643
QL + ++ E+E + Q L +LE + + E +LR L
Sbjct: 1902 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1953
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 106 bits (264), Expect = 1e-22
Identities = 171/721 (23%), Positives = 298/721 (41%), Gaps = 105/721 (14%)
Query: 139 ALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG 198
A Q+ E++V +L+ EEE +T +K RL+ ELEA AE+ R +
Sbjct: 932 ARKQELELVVSELEARVGEEEECSRQMQT---EKKRLQQHIQELEAHLEAEEGARQK--- 985
Query: 199 LRAALAGAEVVRKNLEEG------SQRELEEVQRLHQEQL---SSLTQAHEEALSSLTS- 248
L+ E K EE +L + ++L +++L SS EE + SL
Sbjct: 986 LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKL 1045
Query: 249 ----------------KAEGLEKSLSSLETRRAGEAKEL----AEAQREAELLRKQLSKT 288
K E + L L+ R GE+ EL E Q+ AE LR QL +
Sbjct: 1046 RLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRK 1105
Query: 289 QEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ 348
+E+L+A + E+ + + S +Q L E + L+ +R + +
Sbjct: 1106 EEELQAALARAEDEGGARAQLLKSLREAQA------ALAEAQEDLESER--------VAR 1151
Query: 349 VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 408
+ + L + E L +++ D+L+ T Q L ++ ++V L L+ + H
Sbjct: 1152 TKAEKQRRDLGEELEALRGELE--DTLDS--TNAQQELRSKREQEVTELKKTLEEETRIH 1207
Query: 409 SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDK---AAEVEVERMGAKGLQLELSRAQ 465
+V++L+ + ++ Q EQA + +K A E EV L+ ELS Q
Sbjct: 1208 EAAVQELRQRHGQALGELAEQ-LEQARRGKGAWEKTRLALEAEVSE-----LRAELSSLQ 1261
Query: 466 EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 525
AR+ +Q+ E QL+ V + K++ A A+L +++ L+ A K
Sbjct: 1262 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-- 1319
Query: 526 TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGR 585
TIR ++++L+ + + + Q+L +E R L R ++ E
Sbjct: 1320 TIR--LSKELSSTEAQLH-------------DAQELLQEETRAKLALGSRVRAMEAEAAG 1364
Query: 586 AREQGEAE---RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
REQ E E R++ + Q + +L + + LE + ++ + EA +L Q
Sbjct: 1365 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1424
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQ--E 700
L ++ E +++ RL+++L D L + R + V +L + QR+ Q
Sbjct: 1425 LAEKTETV-----DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLA 1475
Query: 701 KERSQELRRLQEEARKE-EGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTV-L 758
+E++ LR ++E R E EG+ R L R +QE +Q R L L
Sbjct: 1476 EEKAAVLRAVEERERAEAEGREREARALSLTR-----ALEEEQEAREELERQNRALRAEL 1530
Query: 759 PSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVC 818
+LL K V S E + AA ++ ++ L D+L +A + E
Sbjct: 1531 EALLSSKDDVGKSVHELERACRVAEQAA----NDLRAQVTELEDELTAAEDAKLRLEVTV 1586
Query: 819 Q 819
Q
Sbjct: 1587 Q 1587
Score = 97.4 bits (241), Expect = 5e-20
Identities = 160/684 (23%), Positives = 280/684 (40%), Gaps = 101/684 (14%)
Query: 154 LRRLEEE----VRLLRETSLQQKMRLEAQA-MELEALAR--AEKAGR---AEAEGLRAAL 203
L R E+E +LL+ Q EAQ +E E +AR AEK R E E LR L
Sbjct: 1113 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1172
Query: 204 --------AGAEVVRKNLEEGSQ--RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 253
A E+ K +E ++ + LEE R+H+ + L Q H +AL L + E
Sbjct: 1173 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1232
Query: 254 EKSLSSLE-TRRAGEAK---------ELAEAQREAELLRKQLSKTQEDLEAQVTLVENLR 303
+ + E TR A EA+ L A++E E R++L ++++ + E R
Sbjct: 1233 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1292
Query: 304 KYVGEQV---PSEVHSQTWELE--RQKLLETMQHLQEDRDSLHATAELLQ---------- 348
E++ +E+ + + L K + + L LH ELLQ
Sbjct: 1293 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1352
Query: 349 VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 408
RV+++ A E+L + + E + Q+ L+ WR + L+A E
Sbjct: 1353 SRVRAMEAEAAGLREQLEEEAAARERAGREL-QTAQAQLSEWRRRQEEEAGALEAGEEAR 1411
Query: 409 SDSVKQLKGQVASLQEK---VTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE----- 460
+ ++ + L EK V + + LQ+ L D ++E +R L+ +
Sbjct: 1412 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1471
Query: 461 ---------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
+ RA E R R + + E + + A+ Q E + A+L
Sbjct: 1472 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1531
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE 571
+L + + VH + + A Q + L VT++ EL + + RL+
Sbjct: 1532 ALLSSKDDVGKSVHEL------ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1585
Query: 572 LQLSARLIQQEVGRAREQGEAERQQLSKVAQ--QLEQELQQTQESLA------------S 617
+Q ++++ E GE R+QL+K + ++E++ ++ Q +LA
Sbjct: 1586 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1645
Query: 618 LGLQLEVARQGQQESTEEAASLRQEL-----------TQQQELYGQALQE----KVAEVE 662
L Q+ A QG++E+ ++ ++ ++ T ++E++ Q + K E E
Sbjct: 1646 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1705
Query: 663 T-RLREQL--SDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 719
RL+E+L SD RR + R+ V+ + + A E++R E R Q E EE
Sbjct: 1706 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1765
Query: 720 QRLARRLQELERDKNLMLATLQQE 743
Q + L + R L + +L E
Sbjct: 1766 QSNSELLNDRYRKLLLQVESLTTE 1789
Score = 93.6 bits (231), Expect = 7e-19
Identities = 176/707 (24%), Positives = 293/707 (41%), Gaps = 117/707 (16%)
Query: 120 SDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQA 179
+++ E RRG+ G L+ +AEV ELR ++ R+ Q++ RLE Q
Sbjct: 1226 AEQLEQARRGK--GAWEKTRLALEAEV-----SELRAELSSLQTARQEGEQRRRRLELQL 1278
Query: 180 MELEALARAEKAGRAE-AEGLRAALAGAEVVRKNLEEGS------QRELEEVQ-RLHQEQ 231
E++ A + RAE AE L+ A A E V L E +EL + +LH Q
Sbjct: 1279 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1338
Query: 232 LSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLS---KT 288
L Q A +L S+ +E + L + EA A RE + + QLS +
Sbjct: 1339 --ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1396
Query: 289 QEDLEAQVTLVENLRKYVGEQ------------------------VPSEVHSQTWELERQ 324
QE+ + E R+ + + E+ T +LE+Q
Sbjct: 1397 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1456
Query: 325 K-LLETMQHLQEDRDSLHA---TAELLQVRVQSLTHILALQEE----ELTRKVQPSDSLE 376
+ L+ T++ Q D L A A L V + + E LTR ++
Sbjct: 1457 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1516
Query: 377 PEFTRKCQSLLNRWREKVFALM-----VQLKAQELEHS-----DSVKQLKGQVASLQEKV 426
E R+ ++L R ++ AL+ V ELE + + L+ QV L++++
Sbjct: 1517 EELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1572
Query: 427 TSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAE------- 479
T + E A L+ + +A + + ER LQ +E RR+ +Q AE
Sbjct: 1573 T--AAEDAKLRLEVTVQALKTQHER----DLQGRDEAGEERRRQLAKQLRDAEVERDEER 1626
Query: 480 EQLRLVVNAVSSSQIWLETTMAKV-------EGAAAQLPSLNNRLSYAVRKVHTIRGLIA 532
+Q L V A + LE A++ E A QL + ++ R+V R +
Sbjct: 1627 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR--TS 1684
Query: 533 RKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 592
R+ +Q R+ L +V L LQ+ +R + Q + EV A
Sbjct: 1685 REEIFSQNRESEKRLKGLEAEV-LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1743
Query: 593 ---ERQQLSKVAQQLEQELQQTQESLASLG-------LQLE---VARQGQQESTEEAASL 639
E++QL QLE+EL++ Q + L LQ+E ++ + +A S
Sbjct: 1744 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1803
Query: 640 RQELTQQ-QELYGQALQEKVAEVETR-------LREQLSDTERRLNEARREHAKAVVSLR 691
RQ+L +Q QEL G+ L E+ A R L +L+ E +L + RE + +R
Sbjct: 1804 RQQLERQIQELRGR-LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1862
Query: 692 QIQRRAAQEKERSQELRRLQEEARK--EEG----QRLARRLQELERD 732
+ ++R + + +E RR+ ++ R E+G ++L R+L+E E +
Sbjct: 1863 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1909
Score = 90.9 bits (224), Expect = 4e-18
Identities = 145/582 (24%), Positives = 246/582 (42%), Gaps = 63/582 (10%)
Query: 257 LSSLETRRAGEAKELA---EAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 313
L+ LE R + ++ +A L R+ K Q+ A + N Y+ +
Sbjct: 792 LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLR---- 847
Query: 314 VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEE------ELTR 367
H Q W L K+ +Q ++D E+LQ R Q L + LQ++ EL
Sbjct: 848 -HWQWWRLFT-KVKPLLQVTRQD--------EVLQARAQELQKVQELQQQSAREVGELQG 897
Query: 368 KVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQ----LKAQELEHSDSVKQLKGQVASLQ 423
+V LE E R + L R ++ A + L A++ E V +L+ +V +
Sbjct: 898 RVA---QLEEERARLAEQL--RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEE 952
Query: 424 EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLR 483
E E+ LQ+ +Q+ A +E E + LQLE + +++++ E+Q
Sbjct: 953 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQ-- 1010
Query: 484 LVVNAVSSSQIWLETTMAKVEGAAAQ----LPSLNN-RLSYAVRKVHTIRGLIARKLALA 538
+ +S + LE +A+ AA+ + SLN RL Y TI + R
Sbjct: 1011 --NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEA----TIADMEDRLRKEE 1064
Query: 539 QLRQESCPLPPPVTDVSLELQ-QLREERNR---LDAELQLSARLIQQEVGRAREQGEAER 594
+ RQE L + S ELQ Q+ E++ R L A+L +Q + RA ++G A R
Sbjct: 1065 KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA-R 1123
Query: 595 QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL 654
QL K ++ + L + QE L S + A + +++ EE +LR EL + L
Sbjct: 1124 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL--EDTLDSTNA 1181
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 714
Q+ E+ ++ +++++ ++ L E R H AV LRQ +A E E R + A
Sbjct: 1182 QQ---ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1238
Query: 715 RKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRP 774
++ L + EL + + L T +QEG R + L L + +
Sbjct: 1239 WEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRR-------LELQLQEVQGRAGDGER 1290
Query: 775 PECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEA 816
A+ + A E++ G+L+ LS+ +S EA
Sbjct: 1291 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1332
Score = 84.0 bits (206), Expect = 5e-16
Identities = 130/592 (21%), Positives = 236/592 (39%), Gaps = 77/592 (13%)
Query: 102 RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQE----LRRL 157
R L T + Q++ W R RQE G E + +++AE + ++L E + RL
Sbjct: 1381 RELQTAQAQLSEWRR-----RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1435
Query: 158 EEEVRLLRETSLQQKMRLEAQAMELEALARAE-KAGRAEAEGLRAALAGAEVVRKNLEEG 216
E R L++ M LE Q + L + + K + AE A L E + EG
Sbjct: 1436 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1495
Query: 217 SQRE---------LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE 267
+RE LEE Q +E+L +A L +L S + + KS+ LE
Sbjct: 1496 REREARALSLTRALEEEQEA-REELERQNRALRAELEALLSSKDDVGKSVHELE------ 1548
Query: 268 AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWE 320
+ A++ A LR Q+++ +++L A LR V Q H + E
Sbjct: 1549 -RACRVAEQAANDLRAQVTELEDELTAAEDA--KLRLEVTVQALKTQHERDLQGRDEAGE 1605
Query: 321 LERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT 380
R++L + ++ + +RD L + L L + ++ Q + +
Sbjct: 1606 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLR 1665
Query: 381 RKCQSLLNRWRE--KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR 438
+ + WRE + ++ +Q E +K L+ +V LQE++ + + + Q+
Sbjct: 1666 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1725
Query: 439 SLQDKAAEVEVERMGAKGL-----QLE--LSRAQEARRRWQQQTASAEEQLRLVVNAVSS 491
+ A EV + + QLE L + +E Q + ++ R ++ V S
Sbjct: 1726 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVES 1785
Query: 492 SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 551
L T ++ +A+ S +L R++ +RG + + A A+ R + +
Sbjct: 1786 ----LTTELSAERSFSAKAESGRQQLE---RQIQELRGRLGEEDAGARARHKMT-----I 1833
Query: 552 TDVSLELQQLREERNRLDAELQLSARLIQQEVGRARE---QGEAERQ------------- 595
+ +L Q E+ + E LS +L+++ R +E Q E ER+
Sbjct: 1834 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1893
Query: 596 ----QLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQEL 643
QL + ++ E+E + Q L +LE + + E +LR L
Sbjct: 1894 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1945
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 106 bits (264), Expect = 1e-22
Identities = 171/721 (23%), Positives = 298/721 (41%), Gaps = 105/721 (14%)
Query: 139 ALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEG 198
A Q+ E++V +L+ EEE +T +K RL+ ELEA AE+ R +
Sbjct: 973 ARKQELELVVSELEARVGEEEECSRQMQT---EKKRLQQHIQELEAHLEAEEGARQK--- 1026
Query: 199 LRAALAGAEVVRKNLEEG------SQRELEEVQRLHQEQL---SSLTQAHEEALSSLTS- 248
L+ E K EE +L + ++L +++L SS EE + SL
Sbjct: 1027 LQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKL 1086
Query: 249 ----------------KAEGLEKSLSSLETRRAGEAKEL----AEAQREAELLRKQLSKT 288
K E + L L+ R GE+ EL E Q+ AE LR QL +
Sbjct: 1087 RLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRK 1146
Query: 289 QEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQ 348
+E+L+A + E+ + + S +Q L E + L+ +R + +
Sbjct: 1147 EEELQAALARAEDEGGARAQLLKSLREAQA------ALAEAQEDLESER--------VAR 1192
Query: 349 VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 408
+ + L + E L +++ D+L+ T Q L ++ ++V L L+ + H
Sbjct: 1193 TKAEKQRRDLGEELEALRGELE--DTLDS--TNAQQELRSKREQEVTELKKTLEEETRIH 1248
Query: 409 SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDK---AAEVEVERMGAKGLQLELSRAQ 465
+V++L+ + ++ Q EQA + +K A E EV L+ ELS Q
Sbjct: 1249 EAAVQELRQRHGQALGELAEQ-LEQARRGKGAWEKTRLALEAEVSE-----LRAELSSLQ 1302
Query: 466 EARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVH 525
AR+ +Q+ E QL+ V + K++ A A+L +++ L+ A K
Sbjct: 1303 TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK-- 1360
Query: 526 TIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGR 585
TIR ++++L+ + + + Q+L +E R L R ++ E
Sbjct: 1361 TIR--LSKELSSTEAQLH-------------DAQELLQEETRAKLALGSRVRAMEAEAAG 1405
Query: 586 AREQGEAE---RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE 642
REQ E E R++ + Q + +L + + LE + ++ + EA +L Q
Sbjct: 1406 LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQR 1465
Query: 643 LTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQ--E 700
L ++ E +++ RL+++L D L + R + V +L + QR+ Q
Sbjct: 1466 LAEKTETV-----DRLERGRRRLQQELDDATMDLEQQR----QLVSTLEKKQRKFDQLLA 1516
Query: 701 KERSQELRRLQEEARKE-EGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTV-L 758
+E++ LR ++E R E EG+ R L R +QE +Q R L L
Sbjct: 1517 EEKAAVLRAVEERERAEAEGREREARALSLTR-----ALEEEQEAREELERQNRALRAEL 1571
Query: 759 PSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVC 818
+LL K V S E + AA ++ ++ L D+L +A + E
Sbjct: 1572 EALLSSKDDVGKSVHELERACRVAEQAA----NDLRAQVTELEDELTAAEDAKLRLEVTV 1627
Query: 819 Q 819
Q
Sbjct: 1628 Q 1628
Score = 97.4 bits (241), Expect = 5e-20
Identities = 160/684 (23%), Positives = 280/684 (40%), Gaps = 101/684 (14%)
Query: 154 LRRLEEE----VRLLRETSLQQKMRLEAQA-MELEALAR--AEKAGR---AEAEGLRAAL 203
L R E+E +LL+ Q EAQ +E E +AR AEK R E E LR L
Sbjct: 1154 LARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL 1213
Query: 204 --------AGAEVVRKNLEEGSQ--RELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 253
A E+ K +E ++ + LEE R+H+ + L Q H +AL L + E
Sbjct: 1214 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1273
Query: 254 EKSLSSLE-TRRAGEAK---------ELAEAQREAELLRKQLSKTQEDLEAQVTLVENLR 303
+ + E TR A EA+ L A++E E R++L ++++ + E R
Sbjct: 1274 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERAR 1333
Query: 304 KYVGEQV---PSEVHSQTWELE--RQKLLETMQHLQEDRDSLHATAELLQ---------- 348
E++ +E+ + + L K + + L LH ELLQ
Sbjct: 1334 AEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALG 1393
Query: 349 VRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEH 408
RV+++ A E+L + + E + Q+ L+ WR + L+A E
Sbjct: 1394 SRVRAMEAEAAGLREQLEEEAAARERAGREL-QTAQAQLSEWRRRQEEEAGALEAGEEAR 1452
Query: 409 SDSVKQLKGQVASLQEK---VTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLE----- 460
+ ++ + L EK V + + LQ+ L D ++E +R L+ +
Sbjct: 1453 RRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFD 1512
Query: 461 ---------LSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLP 511
+ RA E R R + + E + + A+ Q E + A+L
Sbjct: 1513 QLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELE 1572
Query: 512 SLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE 571
+L + + VH + + A Q + L VT++ EL + + RL+
Sbjct: 1573 ALLSSKDDVGKSVHEL------ERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVT 1626
Query: 572 LQLSARLIQQEVGRAREQGEAERQQLSKVAQ--QLEQELQQTQESLA------------S 617
+Q ++++ E GE R+QL+K + ++E++ ++ Q +LA
Sbjct: 1627 VQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEE 1686
Query: 618 LGLQLEVARQGQQESTEEAASLRQEL-----------TQQQELYGQALQE----KVAEVE 662
L Q+ A QG++E+ ++ ++ ++ T ++E++ Q + K E E
Sbjct: 1687 LKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE 1746
Query: 663 T-RLREQL--SDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 719
RL+E+L SD RR + R+ V+ + + A E++R E R Q E EE
Sbjct: 1747 VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEE 1806
Query: 720 QRLARRLQELERDKNLMLATLQQE 743
Q + L + R L + +L E
Sbjct: 1807 QSNSELLNDRYRKLLLQVESLTTE 1830
Score = 93.6 bits (231), Expect = 7e-19
Identities = 176/707 (24%), Positives = 293/707 (41%), Gaps = 117/707 (16%)
Query: 120 SDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQA 179
+++ E RRG+ G L+ +AEV ELR ++ R+ Q++ RLE Q
Sbjct: 1267 AEQLEQARRGK--GAWEKTRLALEAEV-----SELRAELSSLQTARQEGEQRRRRLELQL 1319
Query: 180 MELEALARAEKAGRAE-AEGLRAALAGAEVVRKNLEEGS------QRELEEVQ-RLHQEQ 231
E++ A + RAE AE L+ A A E V L E +EL + +LH Q
Sbjct: 1320 QEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQ 1379
Query: 232 LSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLS---KT 288
L Q A +L S+ +E + L + EA A RE + + QLS +
Sbjct: 1380 --ELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRR 1437
Query: 289 QEDLEAQVTLVENLRKYVGEQ------------------------VPSEVHSQTWELERQ 324
QE+ + E R+ + + E+ T +LE+Q
Sbjct: 1438 QEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQ 1497
Query: 325 K-LLETMQHLQEDRDSLHA---TAELLQVRVQSLTHILALQEE----ELTRKVQPSDSLE 376
+ L+ T++ Q D L A A L V + + E LTR ++
Sbjct: 1498 RQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAR 1557
Query: 377 PEFTRKCQSLLNRWREKVFALM-----VQLKAQELEHS-----DSVKQLKGQVASLQEKV 426
E R+ ++L R ++ AL+ V ELE + + L+ QV L++++
Sbjct: 1558 EELERQNRAL----RAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1613
Query: 427 TSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAE------- 479
T + E A L+ + +A + + ER LQ +E RR+ +Q AE
Sbjct: 1614 T--AAEDAKLRLEVTVQALKTQHER----DLQGRDEAGEERRRQLAKQLRDAEVERDEER 1667
Query: 480 EQLRLVVNAVSSSQIWLETTMAKV-------EGAAAQLPSLNNRLSYAVRKVHTIRGLIA 532
+Q L V A + LE A++ E A QL + ++ R+V R +
Sbjct: 1668 KQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETR--TS 1725
Query: 533 RKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEA 592
R+ +Q R+ L +V L LQ+ +R + Q + EV A
Sbjct: 1726 REEIFSQNRESEKRLKGLEAEV-LRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1784
Query: 593 ---ERQQLSKVAQQLEQELQQTQESLASLG-------LQLE---VARQGQQESTEEAASL 639
E++QL QLE+EL++ Q + L LQ+E ++ + +A S
Sbjct: 1785 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1844
Query: 640 RQELTQQ-QELYGQALQEKVAEVETR-------LREQLSDTERRLNEARREHAKAVVSLR 691
RQ+L +Q QEL G+ L E+ A R L +L+ E +L + RE + +R
Sbjct: 1845 RQQLERQIQELRGR-LGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVR 1903
Query: 692 QIQRRAAQEKERSQELRRLQEEARK--EEG----QRLARRLQELERD 732
+ ++R + + +E RR+ ++ R E+G ++L R+L+E E +
Sbjct: 1904 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEE 1950
Score = 90.9 bits (224), Expect = 4e-18
Identities = 145/582 (24%), Positives = 246/582 (42%), Gaps = 63/582 (10%)
Query: 257 LSSLETRRAGEAKELA---EAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSE 313
L+ LE R + ++ +A L R+ K Q+ A + N Y+ +
Sbjct: 833 LAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLR---- 888
Query: 314 VHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEE------ELTR 367
H Q W L K+ +Q ++D E+LQ R Q L + LQ++ EL
Sbjct: 889 -HWQWWRLFT-KVKPLLQVTRQD--------EVLQARAQELQKVQELQQQSAREVGELQG 938
Query: 368 KVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQ----LKAQELEHSDSVKQLKGQVASLQ 423
+V LE E R + L R ++ A + L A++ E V +L+ +V +
Sbjct: 939 RVA---QLEEERARLAEQL--RAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEE 993
Query: 424 EKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLR 483
E E+ LQ+ +Q+ A +E E + LQLE + +++++ E+Q
Sbjct: 994 ECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQ-- 1051
Query: 484 LVVNAVSSSQIWLETTMAKVEGAAAQ----LPSLNN-RLSYAVRKVHTIRGLIARKLALA 538
+ +S + LE +A+ AA+ + SLN RL Y TI + R
Sbjct: 1052 --NSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEA----TIADMEDRLRKEE 1105
Query: 539 QLRQESCPLPPPVTDVSLELQ-QLREERNR---LDAELQLSARLIQQEVGRAREQGEAER 594
+ RQE L + S ELQ Q+ E++ R L A+L +Q + RA ++G A R
Sbjct: 1106 KGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGA-R 1164
Query: 595 QQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQAL 654
QL K ++ + L + QE L S + A + +++ EE +LR EL + L
Sbjct: 1165 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGEL--EDTLDSTNA 1222
Query: 655 QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEA 714
Q+ E+ ++ +++++ ++ L E R H AV LRQ +A E E R + A
Sbjct: 1223 QQ---ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGA 1279
Query: 715 RKEEGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRP 774
++ L + EL + + L T +QEG R + L L + +
Sbjct: 1280 WEKTRLALEAEVSELRAELS-SLQTARQEGEQRRRR-------LELQLQEVQGRAGDGER 1331
Query: 775 PECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEA 816
A+ + A E++ G+L+ LS+ +S EA
Sbjct: 1332 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEA 1373
Score = 84.0 bits (206), Expect = 5e-16
Identities = 130/592 (21%), Positives = 236/592 (39%), Gaps = 77/592 (13%)
Query: 102 RRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQE----LRRL 157
R L T + Q++ W R RQE G E + +++AE + ++L E + RL
Sbjct: 1422 RELQTAQAQLSEWRR-----RQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRL 1476
Query: 158 EEEVRLLRETSLQQKMRLEAQAMELEALARAE-KAGRAEAEGLRAALAGAEVVRKNLEEG 216
E R L++ M LE Q + L + + K + AE A L E + EG
Sbjct: 1477 ERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEG 1536
Query: 217 SQRE---------LEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGE 267
+RE LEE Q +E+L +A L +L S + + KS+ LE
Sbjct: 1537 REREARALSLTRALEEEQEA-REELERQNRALRAELEALLSSKDDVGKSVHELE------ 1589
Query: 268 AKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHS-------QTWE 320
+ A++ A LR Q+++ +++L A LR V Q H + E
Sbjct: 1590 -RACRVAEQAANDLRAQVTELEDELTAAEDA--KLRLEVTVQALKTQHERDLQGRDEAGE 1646
Query: 321 LERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFT 380
R++L + ++ + +RD L + L L + ++ Q + +
Sbjct: 1647 ERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLR 1706
Query: 381 RKCQSLLNRWRE--KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQR 438
+ + WRE + ++ +Q E +K L+ +V LQE++ + + + Q+
Sbjct: 1707 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1766
Query: 439 SLQDKAAEVEVERMGAKGL-----QLE--LSRAQEARRRWQQQTASAEEQLRLVVNAVSS 491
+ A EV + + QLE L + +E Q + ++ R ++ V S
Sbjct: 1767 DRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVES 1826
Query: 492 SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 551
L T ++ +A+ S +L R++ +RG + + A A+ R + +
Sbjct: 1827 ----LTTELSAERSFSAKAESGRQQLE---RQIQELRGRLGEEDAGARARHKMT-----I 1874
Query: 552 TDVSLELQQLREERNRLDAELQLSARLIQQEVGRARE---QGEAERQ------------- 595
+ +L Q E+ + E LS +L+++ R +E Q E ER+
Sbjct: 1875 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGN 1934
Query: 596 ----QLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQEL 643
QL + ++ E+E + Q L +LE + + E +LR L
Sbjct: 1935 LRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRL 1986
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 105 bits (261), Expect = 2e-22
Identities = 176/687 (25%), Positives = 290/687 (42%), Gaps = 106/687 (15%)
Query: 138 QALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAE 197
Q L++ + Q++EL L + V+ L+E L +K + A A++E AGR E
Sbjct: 1064 QELAKLRGLEAAQIKELEELRQTVKQLKE-QLAKKEKEHASGSG----AQSEAAGRTEPT 1118
Query: 198 GLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSL 257
G + AEV + LE+ Q++ QEQ SL ++ E +S + LE
Sbjct: 1119 GPKLEALRAEVSK--LEQQCQKQ--------QEQADSLERSLEAERASRAERDSALETLQ 1168
Query: 258 SSLETR--RAGEAKE-LAEAQREAELLRKQL---SKTQEDLEAQV-----------TLVE 300
LE + G ++ LA AQRE R ++ SK +++ +AQV +L+
Sbjct: 1169 GQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228
Query: 301 NLRKYVG--EQVPSEVHSQTWELER---------QKLLETMQHLQEDRDSLHATA----E 345
+L + V + E ++ EL+R QKL E ++ LQ + S A A
Sbjct: 1229 SLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS 1288
Query: 346 LLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSL------LNRWREKVFALMV 399
L+ VQSL EE ++ S++L E T + + L W+EK F
Sbjct: 1289 ALREEVQSL-------REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341
Query: 400 QLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQL 459
L +LEH+ S + L ++ + EQA ++ ++ E+E + A GL+
Sbjct: 1342 ALSTLQLEHT-STQALVSELLPAKHLCQQLQAEQAAAEKRHRE---ELEQSKQAAGGLRA 1397
Query: 460 ELSRAQ--------------EARRRWQQ---QTASAEEQLRLVVNAVSSSQIWLETTMAK 502
EL RAQ E R QQ + AS EQL ++ A + E
Sbjct: 1398 ELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG---LLAEENRGL 1454
Query: 503 VEGAAAQLPSLNNRLSYA----VRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLEL 558
E A L L A V+++ +R +LA Q +S V E
Sbjct: 1455 GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514
Query: 559 QQLR--EERNRLDAELQ-LSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESL 615
+++ EER R E Q L+A++ Q EV + + + E +LSK +Q + Q+ L
Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVE--ELSKKLADSDQASKVQQQKL 1572
Query: 616 ASLGLQLEVARQGQQESTEEAASLRQELTQQQ---ELYGQALQEKVAEVETR------LR 666
++ Q ++Q Q + L+ +L+Q++ E Y +++ + + L+
Sbjct: 1573 KAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
Query: 667 EQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRL 726
EQL E+ E + A+A ++Q+ + KE Q R L + R E Q +A
Sbjct: 1633 EQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ-VAHAD 1691
Query: 727 QELERDKNLMLATLQQEGLLSRYKQQR 753
Q+L +AT + L SR Q +
Sbjct: 1692 QQLRDLGKFQVAT---DALKSREPQAK 1715
Score = 104 bits (259), Expect = 4e-22
Identities = 181/809 (22%), Positives = 336/809 (41%), Gaps = 121/809 (14%)
Query: 121 DRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAM 180
++Q + S L+ + L ++ E++ +L +L EE + L++ Q+K + +
Sbjct: 357 EKQAQLEKELSAALQDKKCLEEKNEILQGKLSQL---EEHLSQLQDNPPQEKGEVLGDVL 413
Query: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVR-----KNLEEGSQRELEEVQRLH------Q 229
+LE L + A L+A + E R K L E E EE Q+L Q
Sbjct: 414 QLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE-EEKQQLSSLITDLQ 472
Query: 230 EQLSSLTQAHEEALSS-------LTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLR 282
+S+L+QA EE + LT++ L L++L + +ELA +++A+ +
Sbjct: 473 SSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQ 532
Query: 283 KQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELER--QKLLETMQ-HLQEDRDS 339
QL++T L+ Q + LR V EQ+ S + + +L+ +K T Q H Q+ +
Sbjct: 533 AQLAQT---LQQQEQASQGLRHQV-EQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATA 588
Query: 340 LHATAELLQVRVQSLTHILALQEEE------LTRKVQPS----DSLEPEFTR--KCQSLL 387
L+ R +L + AL++E+ L +++Q + DS + T+ + ++ L
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648
Query: 388 NRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQ---SQEQAILQRSLQDKA 444
+R E++ A + + ++ E V +L+ Q+ S Q+K T + +QE+ LQ LQ
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALK 708
Query: 445 AEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVE 504
++V + L+ E RA +A Q+ + + + R +V + LE A +
Sbjct: 709 ESLKVTK---GSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRK 765
Query: 505 GAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCP-LPPPVTDVSLELQQLRE 563
G A+L L + +R +A +A + C L V + ++
Sbjct: 766 GLEARLQQLGEAHQ---AETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 564 ERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLE 623
E + A Q +++E +AR++ + +++++ + E ++ + Q LA L L
Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLA 882
Query: 624 VARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREH 683
A Q QE A L +L+ QE A ++VA +ET +R+ E E +E
Sbjct: 883 RALQQVQEKEVRAQKLADDLSTLQEKMA-ATSKEVARLETLVRKAGEQQETASRELVKEP 941
Query: 684 AKA-------------------VVSLRQIQRRAAQEKERSQELRRL-------QEEARKE 717
A+A +L+ ++R A Q + LR Q+E R +
Sbjct: 942 ARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ 1001
Query: 718 EGQRLAR------------------------RLQELERDKNLMLATLQQ---------EG 744
+ + +AR RLQ ++ + ATLQ+ EG
Sbjct: 1002 QEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEG 1061
Query: 745 L---LSRYK-----QQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGS 796
L++ + Q + L L + + K ++ S S + A E
Sbjct: 1062 KDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPK 1121
Query: 797 LSVLLDDLQDLSEAISKEEAVCQGDNLDR 825
L L ++ L + K++ Q D+L+R
Sbjct: 1122 LEALRAEVSKLEQQCQKQQE--QADSLER 1148
Score = 99.4 bits (246), Expect = 1e-20
Identities = 171/682 (25%), Positives = 282/682 (41%), Gaps = 136/682 (19%)
Query: 138 QALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAE 197
QA+ ++AE + +L+ LR L E+ QQ+ Q E+ L ++ GRA+A+
Sbjct: 968 QAMEREAEQMGNELERLRAA------LMESQGQQQEERGQQEREVARLT--QERGRAQAD 1019
Query: 198 GLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSL 257
LA + R LE Q L E QR+ L +EAL+ ++ EG ++ L
Sbjct: 1020 -----LALEKAARAELEMRLQNALNE-QRVEFATL-------QEALAHALTEKEGKDQEL 1066
Query: 258 SSLETRRAGEAKELAEAQREAELLRKQLSKTQED------------------------LE 293
+ L A + KEL E ++ + L++QL+K +++ L
Sbjct: 1067 AKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALR 1126
Query: 294 AQVTLVENLRKYVGEQVPSEVHSQTWE----LERQKLLETMQ-HLQEDRDSL-------- 340
A+V+ +E + EQ S S E ER LET+Q L+E L
Sbjct: 1127 AEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALA 1186
Query: 341 HATAELLQVRVQSLTHILALQE---------EELTRKVQPSDSLEPEFTRKCQSLLNRWR 391
A EL R + H A E +E RK SLE E S+LNR
Sbjct: 1187 SAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV-----SILNRQV 1241
Query: 392 EKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQS----QEQAILQRSLQDKAAEV 447
+ +LK + S+ ++L+ ++ LQ + S S + + L+ +Q E
Sbjct: 1242 LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA 1301
Query: 448 EVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAA 507
E +R+ ++ L+ EL+ E Q+ + +E+ A+S+ Q+ +T A V
Sbjct: 1302 EKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV---- 1357
Query: 508 AQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNR 567
S + H + L A + A + +E EL+Q ++
Sbjct: 1358 ----------SELLPAKHLCQQLQAEQAAAEKRHRE-------------ELEQSKQAAGG 1394
Query: 568 LDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASL----GLQLE 623
L AEL + R + + + ++ E ER AQQL E E L+ L GL E
Sbjct: 1395 LRAELLRAQRELGELIPLRQKVAEQER-----TAQQLRAEKASYAEQLSMLKKAHGLLAE 1449
Query: 624 VARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREH 683
R + + L EL Q +E Y Q L A+ ETRL E +RE
Sbjct: 1450 ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRL-----------AEVQRE- 1497
Query: 684 AKAVVSLRQIQRRAAQEKERSQELRRLQEEAR-KEEGQRLARRLQELE---RDKNLMLAT 739
A + R+++ A K +++ L+E R +EE Q+L ++++LE R++ +
Sbjct: 1498 --AQSTARELEVMTA--KYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553
Query: 740 LQQE----GLLSRYKQQRLLTV 757
L ++ S+ +QQ+L V
Sbjct: 1554 LSKKLADSDQASKVQQQKLKAV 1575
Score = 98.2 bits (243), Expect = 3e-20
Identities = 152/652 (23%), Positives = 272/652 (41%), Gaps = 87/652 (13%)
Query: 149 RQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAE-----------AE 197
R+ EL R EE++ ET+ Q++ +AQ ELE R+E+ E E
Sbjct: 643 REKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQE 702
Query: 198 GLRAALAGAEVVRKNLEEGSQR---ELEEVQRLHQE---QLSSLTQAHEEALSSLTSKAE 251
L+A +V + +LEE +R LEE QR E + SL + H+ L +
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Query: 252 GLEKSLSSLETRRAGEAKELAEA-QREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQV 310
G + LE R ++L EA Q E E+LR++L++ + E L K V
Sbjct: 763 GRK----GLEAR----LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR 814
Query: 311 PSEVHSQTWELE------------RQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHIL 358
SQ E + +++ + Q LQE ++ + ++++ + L
Sbjct: 815 ERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNEL 874
Query: 359 ALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQL--------KAQELEHSD 410
A L R +Q E +K L+ +EK+ A ++ KA E + +
Sbjct: 875 AELHANLARALQQVQEKEVR-AQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA 933
Query: 411 SVKQLK--GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEAR 468
S + +K + Q + + Q + +A E E E+MG +LE RA
Sbjct: 934 SRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGN---ELERLRAALME 990
Query: 469 RRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIR 528
+ QQQ +++ + + + + K A ++ L N L+ + T++
Sbjct: 991 SQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM-RLQNALNEQRVEFATLQ 1049
Query: 529 GLIARKLA--------LAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQ 580
+A L LA+LR + ++ ++QL+E+ + + E +
Sbjct: 1050 EALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109
Query: 581 QEVGRAREQG---EAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAA 637
+ GR G EA R ++SK LEQ+ Q+ QE SL LE R + E
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSK----LEQQCQKQQEQADSLERSLEAERASRAERDSALE 1165
Query: 638 SLRQELTQQQELYGQ------ALQEKVAEVETRLR-------EQLSDTERRLNEARREHA 684
+L+ +L ++ + G + Q ++A T+++ E + R EA R+++
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS 1225
Query: 685 KAVVSLRQ----IQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERD 732
+ SL + + R+ +++ S+EL+RL A E+ Q+L RL+ L+ +
Sbjct: 1226 -LISSLEEEVSILNRQVLEKEGESKELKRL-VMAESEKSQKLEERLRLLQAE 1275
Score = 97.8 bits (242), Expect = 4e-20
Identities = 165/732 (22%), Positives = 305/732 (41%), Gaps = 112/732 (15%)
Query: 99 VSERRLDTQRPQVTMWERDVSS-DRQEPGRRGRSWGLEG-SQALSQQAEVIVRQL----- 151
+SE + +T R V +R+ + + GR+G L+ +A + EV+ R+L
Sbjct: 736 ISELKAET-RSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 152 ------QELRRLEEEVRLLRET---SLQQKMRLEAQAME-LEALARAEKAGRAEAEGLRA 201
E +L +EV RE S Q++ + A E L L + R E + +
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854
Query: 202 ALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEA---------LSSLTSKAEG 252
+AG E + E R+ E+ LH +L Q E+ LS+L K
Sbjct: 855 KVAGIE---SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAA 911
Query: 253 LEKSLSSLET--RRAGEAKELAEAQ----------REAELLRKQLSKTQEDLEAQVTLVE 300
K ++ LET R+AGE +E A + R+ E L +Q + +A + +E
Sbjct: 912 TSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAME 971
Query: 301 NLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHA-TAELLQVRVQSLTHILA 359
+ +G ++ E R L+E+ QE+R A L Q R ++ LA
Sbjct: 972 REAEQMGNEL---------ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD-LA 1021
Query: 360 LQEE---ELTRKVQPS-DSLEPEFTRKCQSLLNRWREKVFA--LMVQLKAQELEHSDSVK 413
L++ EL ++Q + + EF ++L + EK + +L+ E ++
Sbjct: 1022 LEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE 1081
Query: 414 QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ 473
+L+ V L+E++ + +E A + + A E + L+ E+S+ ++ ++ Q+
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE 1141
Query: 474 QTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIAR 533
Q S E L + + LET ++E A +L + L+ A R++ R +
Sbjct: 1142 QADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQD 1201
Query: 534 --------KLALAQLRQESCPLPPPVTDV-----------------SLELQQLREERNRL 568
K +A+ RQE+ ++ + S EL++L +
Sbjct: 1202 HSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261
Query: 569 DAELQLSARLIQQEV----GRAREQGEAERQQLSKV----------AQQLEQELQQTQES 614
+L+ RL+Q E RA E+ A R+++ + ++ L QEL E
Sbjct: 1262 SQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
Query: 615 LASLGLQLEVARQGQQESTEEAASLRQELTQQQELYG---------QALQEKVAEVETRL 665
LG +L+ ++ + + ++L+ E T Q L Q LQ + A E R
Sbjct: 1322 AEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381
Query: 666 REQLSDTERRLNEARREHAKAVVSLRQ---IQRRAAQEKERSQELRRLQEEARKEEGQRL 722
RE+L +++ R E +A L + ++++ A+++ +Q+LR E+A E +
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR--AEKASYAEQLSM 1439
Query: 723 ARRLQELERDKN 734
++ L ++N
Sbjct: 1440 LKKAHGLLAEEN 1451
Score = 94.4 bits (233), Expect = 4e-19
Identities = 159/674 (23%), Positives = 277/674 (41%), Gaps = 90/674 (13%)
Query: 149 RQLQELRRLEEEVRL-LRETSLQ-QKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA 206
++L+ELR E + + L ET Q Q ++ E M+ + +E+ G
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG-------------- 321
Query: 207 EVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLS-SLETRRA 265
+L + +Q+L Q+ L+ LT+ H +A K LEK LS +L+ ++
Sbjct: 322 -----DLSFKLREFASHLQQL-QDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC 375
Query: 266 GEAK-ELAE---AQREAELLRKQLSKTQE------DLEAQVTLVENLRKYVGEQVPSEVH 315
E K E+ + +Q E L + Q + QE D+ TL + +
Sbjct: 376 LEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR 435
Query: 316 SQTWELER----QKLLETMQHLQEDRDSLHATAELLQVRVQSLTHI-------------- 357
+ E ER KLL H +E++ L + LQ + +L+
Sbjct: 436 VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGAR 495
Query: 358 LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQE-----LEH---- 408
L Q LT ++ ++ + ++ L + +EK L L+ QE L H
Sbjct: 496 LTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQ 555
Query: 409 -SDSVKQLKGQVASLQEK-------------VTSQSQEQAILQRSLQDKAAEVEVERMGA 454
S S+KQ + Q+ + EK ++ +E ++ +R K E + A
Sbjct: 556 LSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAA 615
Query: 455 K--GLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPS 512
K LQ +L A EAR Q A+ + + V Q +ET + A AQ+
Sbjct: 616 KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE 675
Query: 513 LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLR-----EERNR 567
L +L +K T + +A++ Q + ++ VT SLE ++ R EE+ R
Sbjct: 676 LELQLRSEQQKA-TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQR 734
Query: 568 LDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQ 627
+EL+ R + ++ R R++ E ER + +L+Q + Q L +L A
Sbjct: 735 CISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 628 GQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAV 687
Q + E L +E+ +E Y + QE+ A+ +EQL + +AR+E +A
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEE-AQYGAMFQEQLMTLKEECEKARQELQEAK 853
Query: 688 VSLRQIQRRAAQEKERSQ-ELRRLQEEARK--EEGQRLARRLQELERDKNLMLATLQQEG 744
+ I+ + + R Q EL L + ++ Q R Q+L D L+TLQ++
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADD----LSTLQEKM 909
Query: 745 LLSRYKQQRLLTVL 758
+ + RL T++
Sbjct: 910 AATSKEVARLETLV 923
Score = 80.5 bits (197), Expect = 6e-15
Identities = 119/516 (23%), Positives = 227/516 (43%), Gaps = 64/516 (12%)
Query: 267 EAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKL 326
E KEL E + + E L +L +T + + T + + + +++ + +L KL
Sbjct: 274 EPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI-----NQLSEENGDLSF-KL 327
Query: 327 LETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSL 386
E HLQ+ +D+L+ E Q A E+EL+ +Q LE +
Sbjct: 328 REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEK-------- 379
Query: 387 LNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRS---LQDK 443
E + + QL+ + D+ Q KG+V ++ + QE A L + LQ +
Sbjct: 380 ----NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQAR 435
Query: 444 AAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTM--- 500
+E ER G + +L R + QQ +S L+ ++ +S ++ LE
Sbjct: 436 VEMLETER-GQQEAKLLAERGHFEEEK--QQLSSLITDLQSSISNLSQAKEELEQASQAH 492
Query: 501 -----AKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLA-----LAQLRQESCPLPPP 550
A+V ++L +LN + +++ ++ K A L Q Q S L
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552
Query: 551 VTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQ 610
V +S L+Q ++ + + + + + Q++ A E+ EA ++ +QLE ++
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 611 TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLS 670
L L QL+VA + + + S+ Q ++ EL + ++E A VET +EQ
Sbjct: 613 KAAKLEILQQQLQVANEARDSA---QTSVTQAQREKAEL-SRKVEELQACVETARQEQ-- 666
Query: 671 DTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEAR-------------KE 717
+EA+ + A+ + LR Q++A +++ +QE +LQE+ + +E
Sbjct: 667 ------HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 720
Query: 718 EGQRLARRLQELERDKNLMLATLQQEGLLSRYKQQR 753
E +R A L+E +R + + A + L+ ++K++R
Sbjct: 721 EKRRAADALEEQQRCISELKA--ETRSLVEQHKRER 754
Score = 77.8 bits (190), Expect = 4e-14
Identities = 139/630 (22%), Positives = 263/630 (41%), Gaps = 86/630 (13%)
Query: 94 SGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQ- 152
+G + + +L+ R +V+ E+ +++ RS LE +A + + + LQ
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERS--LEAERASRAERDSALETLQG 1169
Query: 153 ELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKN 212
+L +E+ + + L A +++ ++AE +A+ A E RKN
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV-----ARGRQEAERKN 1224
Query: 213 LEEGSQRELEEVQRLHQEQLSSLTQAHE--EALSSLTSKAEGLEKSLSSLETRRAGEAKE 270
S E EV L+++ L ++ E + + + K++ LE+ L L+ A +
Sbjct: 1225 SLISSLEE--EVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSAR 1282
Query: 271 LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVP-SEVHSQTWELERQKLLET 329
AE + LR+++ +E+ E Q ENLR+ + Q +E Q + ++K +
Sbjct: 1283 AAE---RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQK 1339
Query: 330 MQHLQ----EDRDSLHATAELLQVR--VQSLTHILALQE----EELTRKVQPSDSLEPEF 379
Q L E + +ELL + Q L A E EEL + Q + L E
Sbjct: 1340 EQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAEL 1399
Query: 380 TRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAIL--- 436
R + L ++ L+ + E + +QL+ + AS E+++ + +L
Sbjct: 1400 LRAQREL---------GELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
Query: 437 QRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTAS----AEEQLRLVVNAVSSS 492
R L ++A +G + L++EL +A+E ++ Q+ A+ AE +L V S+
Sbjct: 1451 NRGLGERA------NLGRQFLEVELDQARE---KYVQELAAVRADAETRLAEVQREAQST 1501
Query: 493 QIWLETTMAKVEGAAAQLPSLNNR-------LSYAVRKVHTIRGLIARKLA-----LAQL 540
LE AK EGA ++ R L+ V ++ + +++ LA
Sbjct: 1502 ARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADS 1561
Query: 541 RQESCPLPPPVTDVSLELQQLREERNRLDAEL-QLSARLIQQE---------VGRAREQG 590
Q S + V + + ++E RL A+L +L A+L Q+E + +A+
Sbjct: 1562 DQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHY 1621
Query: 591 EAERQQ-------------LSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAA 637
+A++QQ L K ++L E ++ L GL+ + A Q + T +
Sbjct: 1622 DAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVR 1681
Query: 638 SLRQELTQQQELYGQALQEKVAEVETRLRE 667
SL ++ + + +VA + RE
Sbjct: 1682 SLEAQVAHADQQLRDLGKFQVATDALKSRE 1711
Score = 68.9 bits (167), Expect = 2e-11
Identities = 125/527 (23%), Positives = 207/527 (39%), Gaps = 99/527 (18%)
Query: 33 SGLAEPWRELWRWRSRPLHCVPPFSPLARSSRDHRNLRRRGNIDGWRQNLEPSNNVEMFP 92
S LA REL +R++ +++ + + RG + R+N S+ E
Sbjct: 1183 SALASAQRELAAFRTK-------VQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVS 1235
Query: 93 PSGHQDVSERRLDTQRPQVTMWERDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQ 152
Q + + + ++ M E + S +E R ++ S ++++ + ++Q
Sbjct: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ 1295
Query: 153 ELRRLEEEVRL----LRETSLQQKMRLEAQAMELEA------------------------ 184
LR E+ R+ LR+ Q R E EL+A
Sbjct: 1296 SLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355
Query: 185 ------------------LARAEKAGRAEAEGLRAALAG--AEVVRKNLEEGSQRELEEV 224
A AEK R E E + A G AE++R +QREL E+
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLR------AQRELGEL 1409
Query: 225 QRLHQ---------EQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQ 275
L Q +QL + ++ E LS L KA G L + E R GE L
Sbjct: 1410 IPLRQKVAEQERTAQQLRAEKASYAEQLSML-KKAHG----LLAEENRGLGERANLGRQF 1464
Query: 276 REAELLRKQLSKTQE----DLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQ 331
E EL + + QE +A+ L E R+ EV + +E + K+LE Q
Sbjct: 1465 LEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQ 1524
Query: 332 HLQEDRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWR 391
QE+R L A E L+V + T Q EEL++K+ SD +K +++ +
Sbjct: 1525 RFQEERQKLTAQVEQLEVFQREQTK----QVEELSKKLADSDQASKVQQQKLKAVQAQGG 1580
Query: 392 E------KVFALMVQLKAQELEHSDSVKQLKGQV--------ASLQEKVTSQSQEQAILQ 437
E ++ A + +L+AQ + + + K Q+ A Q+ Q Q +++ Q
Sbjct: 1581 ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQ 1640
Query: 438 RSLQDKAAEVEVERMGAKGLQ--LELSRAQEARRRWQQQTASAEEQL 482
++K E ER+G + Q L+ A++ R Q S E Q+
Sbjct: 1641 LQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQV 1687
Score = 65.9 bits (159), Expect = 2e-10
Identities = 130/522 (24%), Positives = 203/522 (38%), Gaps = 102/522 (19%)
Query: 138 QALSQQAEVIVRQLQELRRLEEEVRLLRET-SLQQKMRLEAQAMELEAL----------- 185
Q L+ QAE QEL+ +E+ + S Q QA+ E L
Sbjct: 1313 QELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQA 1372
Query: 186 --ARAEKAGRAEAEGLRAALAG--AEVVRKNLEEGS----QRELEEVQRLHQEQLSSLTQ 237
A AEK R E E + A G AE++R E G ++++ E +R Q QL +
Sbjct: 1373 EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ-QLRAEKA 1431
Query: 238 AHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQE----DLE 293
++ E LS L KA GL E R GE L E EL + + QE +
Sbjct: 1432 SYAEQLSML-KKAHGLLAE----ENRGLGERANLGRQFLEVELDQAREKYVQELAAVRAD 1486
Query: 294 AQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQS 353
A+ L E R+ EV + +E + K+LE Q QE+R L A E L+V +
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
Query: 354 LTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVK 413
T Q EEL++K+ SD +K LKA + + +S
Sbjct: 1547 QTK----QVEELSKKLADSDQASKVQQQK------------------LKAVQAQGGES-- 1582
Query: 414 QLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQ 473
QE LQ L + A++ + A+ +L++ +A+ +Q
Sbjct: 1583 ----------------QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQ 1626
Query: 474 QTASAEEQLRLVVNAVSSS---------------QIWLETTMAK--VEGAAAQLPSLNNR 516
Q +EQLR + + Q L+T A+ AQ+ SL +
Sbjct: 1627 QNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQ 1686
Query: 517 LSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSA 576
+++A ++ +R L ++A L+ P P D+S++ L E L +++
Sbjct: 1687 VAHADQQ---LRDLGKFQVATDALKSRE-PQAKPQLDLSIDSLDLSCEEG---TPLSITS 1739
Query: 577 RLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASL 618
+L + + GE A + Q L ESL SL
Sbjct: 1740 KLPRTQPDGTSVPGEP--------ASPISQRLPPKVESLESL 1773
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 104 bits (259), Expect = 4e-22
Identities = 154/712 (21%), Positives = 296/712 (41%), Gaps = 107/712 (15%)
Query: 156 RLEEEVRLLRETSLQQKMR-LEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKNL 213
R+E+E L + LQ+K++ L+A+ ELE AE+ RA+ E LR+ L+ E + + L
Sbjct: 1093 RIEDEQAL--GSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERL 1150
Query: 214 EEGS--------------------QRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGL 253
EE +R+LEE H+ ++L + H ++++ L + + L
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNL 1210
Query: 254 EKSLSSLETRRAGEAKELAEAQREAELLRK---QLSKTQEDLEAQV----TLVENLRKYV 306
++ LE ++ EL + E + K L K LE Q+ + E ++ V
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Query: 307 GEQVPSEVHSQT--WELERQ--------------KLLETMQ------HLQEDRDSLHATA 344
+ QT EL RQ KL T Q L+E+ + +A A
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330
Query: 345 ELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ 404
LQ S H L E+ + + L+ + K S + +WR K +Q + +
Sbjct: 1331 HALQ----SARHDCDLLREQYEEETEAKAELQRVLS-KANSEVAQWRTKYETDAIQ-RTE 1384
Query: 405 ELEHSDS-----VKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQL 459
ELE + +++ + V ++ K +S + + LQ ++D +VE A L
Sbjct: 1385 ELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1444
Query: 460 ELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSY 519
+ + W+Q+ SQ LE++ + + +L L N
Sbjct: 1445 KQRNFDKILAEWKQK--------------YEESQSELESSQKEARSLSTELFKLKNAYEE 1490
Query: 520 AVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAE-LQLSARL 578
++ + T K L++E L + + +L + R +L+AE ++L + L
Sbjct: 1491 SLEHLETF------KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544
Query: 579 IQQEVGRAREQGEAERQQLS----------KVAQQLEQELQQTQESLASLGLQLEVARQG 628
+ E E+G+ R QL K+A++ ++E++Q + + + L+ +
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEK-DEEMEQAKRNHLRVVDSLQTSLDA 1603
Query: 629 QQESTEEAASLRQELT---QQQELYGQALQEKVAEVETR---LREQLSDTERRLNEARRE 682
+ S EA +++++ + E+ AE + + L+ L DT+ +L++A R
Sbjct: 1604 ETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1663
Query: 683 HAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLARRLQELERDKNLMLATLQQ 742
+ ++ ++RR + +ELR + E+ E ++LA + + +E + + L Q
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQT--ERSRKLAEQ-ELIETSERVQLLHSQN 1720
Query: 743 EGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIK 794
L+++ K ++ L L + + V R E A + A E +K
Sbjct: 1721 TSLINQKK--KMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK 1770
Score = 93.2 bits (230), Expect = 9e-19
Identities = 156/766 (20%), Positives = 324/766 (42%), Gaps = 114/766 (14%)
Query: 135 EGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRA 194
E ++ L + E+ + R+LE+E +++ + +EL LA+ EK A
Sbjct: 921 EMNERLEDEEEMNAELTAKKRKLEDEC---------SELKRDIDDLEL-TLAKVEKEKHA 970
Query: 195 ---EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAE 251
+ + L +AG + + L +E + +Q HQ+ L L QA E+ +++LT
Sbjct: 971 TENKVKNLTEEMAGLDEIIAKL----TKEKKALQEAHQQALDDL-QAEEDKVNTLTKAKV 1025
Query: 252 GLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVP 311
LE+ + LE E K + +R L L TQE + +EN ++ + E++
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE----SIMDLENDKQQLDERLK 1081
Query: 312 S---EVHSQTWELE---------RQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILA 359
E+++ +E ++KL E ++E + L A + +V+ L L+
Sbjct: 1082 KKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA-ERTARAKVEKLRSDLS 1140
Query: 360 LQEEELTRKVQP---SDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQ----ELEHSDSV 412
+ EE++ +++ + S++ E +K ++ + R + +Q +A +H+DSV
Sbjct: 1141 RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV 1200
Query: 413 KQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVE--------VERMGAKGLQLEL--- 461
+L Q+ +LQ +E++ + L D + +E +E+M + L+ ++
Sbjct: 1201 AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKM-CRTLEDQMNEH 1259
Query: 462 -SRAQEARR--------RWQQQTASAE-----EQLRLVVNAVSSSQIWLETTMAKVEGAA 507
S+A+E +R R + QT + E ++ +++ ++ ++ + ++
Sbjct: 1260 RSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQL 1319
Query: 508 AQLPSLNNRLSYAVRKVHTIRGLIARKL-----ALAQLRQESCPLPPPV--------TDV 554
+ N L++A++ L+ + A A+L++ V TD
Sbjct: 1320 EEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA 1379
Query: 555 SLELQQLREERNRLDAELQ--------LSARLIQQEVGRAREQGEAER-----QQLSKVA 601
++L E + +L LQ ++A+ E + R Q E E ++ + A
Sbjct: 1380 IQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAA 1439
Query: 602 QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQ--EKVA 659
L+++ + + LA + E ++ + S +EA SL EL + + Y ++L+ E
Sbjct: 1440 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1499
Query: 660 EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEK-ERSQELRRLQEEARKEE 718
L+E++SD +L + K + L +++++ EK E L + EE
Sbjct: 1500 RENKNLQEEISDLTEQLGSS----GKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 719 GQRLARRLQ--ELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDK-----------K 765
G+ L +L+ +++ + LA +E ++ R++ L + LD K
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 766 KSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAI 811
K + E S A ++ +K S+L D L +A+
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV 1661
Score = 84.7 bits (208), Expect = 3e-16
Identities = 115/555 (20%), Positives = 223/555 (40%), Gaps = 59/555 (10%)
Query: 252 GLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGE--- 308
GL L + R +AQ L R + K E ++ + + N+R ++G
Sbjct: 768 GLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNW 827
Query: 309 -------QVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQ 361
++ + S E E + E L+E + A + L+ ++ SL +
Sbjct: 828 PWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQ----E 883
Query: 362 EEELTRKVQPSDSLEPEFTRKCQSL-------------LNRWREKVFALMVQLKAQELEH 408
+ +L +VQ + +C L +N E + +L A++ +
Sbjct: 884 KNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKL 943
Query: 409 SDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEAR 468
D +LK + L+ + +E + + ++K + E G + +L++ ++A
Sbjct: 944 EDECSELKRDIDDLELTLAKVEKE----KHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 999
Query: 469 RRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIR 528
+ QQ + VN ++ +++ LE + +EG+ Q + L A RK+
Sbjct: 1000 QEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE--G 1057
Query: 529 GLIARKLALAQLRQESCPLPPPVTDVSLELQQLR---EERNRLDAELQLSARLIQQEVGR 585
L + ++ L + L + EL L E+ L ++LQ + +Q +
Sbjct: 1058 DLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEE 1117
Query: 586 AREQGEAE---RQQLSKVAQQLEQELQQTQESLASLG----LQLEVARQGQQESTEEAAS 638
E+ EAE R ++ K+ L +EL++ E L G +Q+E+ ++ + E +
Sbjct: 1118 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRD 1177
Query: 639 LRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAA 698
L +E T Q E AL++K A+ L EQ+ + +R + +E ++ + L +
Sbjct: 1178 L-EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1236
Query: 699 QEKERSQELRRLQE--EARKEEGQRLARRLQELERDKNLMLATLQQE-GLLSRYKQQRLL 755
Q + L ++ E + E + A Q D A LQ E G LSR
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ------ 1290
Query: 756 TVLPSLLDKKKSVVS 770
LD+K++++S
Sbjct: 1291 ------LDEKEALIS 1299
Score = 76.6 bits (187), Expect = 9e-14
Identities = 132/644 (20%), Positives = 267/644 (41%), Gaps = 72/644 (11%)
Query: 140 LSQQAEVIVRQLQELRRLEEEVRL-LRETSLQQKMRLEAQAMELEALARAEK----AGRA 194
L +Q + + R Q+L + + E +L L + + + ++A+A LE + R + R+
Sbjct: 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA-NLEKMCRTLEDQMNEHRS 1261
Query: 195 EAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLE 254
+AE + ++ R L Q E E+ R E+ + ++Q L+ T + E L+
Sbjct: 1262 KAEETQRSVNDLTSQRAKL----QTENGELSRQLDEKEALISQLTRGKLT-YTQQLEDLK 1316
Query: 255 KSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGE------ 308
+ L + A L A+ + +LLR+Q +E+ EA+ L L K E
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQY---EEETEAKAELQRVLSKANSEVAQWRT 1373
Query: 309 QVPSEVHSQTWELE--RQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQEEELT 366
+ ++ +T ELE ++KL + +Q +E ++++A L+ H L + E+L
Sbjct: 1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE----KTKHRLQNEIEDLM 1429
Query: 367 RKVQPSDSLEPEFTRKCQS---LLNRWREKVFALMVQLKAQELEH---SDSVKQLKGQVA 420
V+ S++ +K ++ +L W++K +L++ + E S + +LK
Sbjct: 1430 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYE 1489
Query: 421 SLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGL---QLELSRAQEARRRWQQQTAS 477
E + + +E LQ + D E++G+ G +LE R Q + + Q+A
Sbjct: 1490 ESLEHLETFKRENKNLQEEISDLT-----EQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544
Query: 478 AEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRK-VHTIRGLIARKLA 536
E + L + LE K E +L + + A R + + L A
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAE-IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA 1603
Query: 537 LAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQE-------------- 582
+ R E+ + + E++ NR+ AE Q + +Q
Sbjct: 1604 ETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1663
Query: 583 ----------VGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQES 632
V R +AE ++L V +Q E+ + ++ L ++++
Sbjct: 1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL 1723
Query: 633 TEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQ 692
+ + +L+Q Q +A+QE E + ++ ++D E ++E + L +
Sbjct: 1724 INQKKKMDADLSQLQTEVEEAVQE-CRNAEEKAKKAITDAAMMAEELKKEQDTSA-HLER 1781
Query: 693 IQRRAAQE----KERSQELRRLQEEARKEEGQRLARRLQELERD 732
+++ Q + R E ++ + K++ Q+L R++ELE +
Sbjct: 1782 MKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENE 1825
Score = 74.7 bits (182), Expect = 3e-13
Identities = 126/638 (19%), Positives = 253/638 (39%), Gaps = 86/638 (13%)
Query: 136 GSQALSQQAEVIVRQLQE-----------LRRLEEEVRLLRETSLQQKMRLEAQA----- 179
G +QQ E + RQL+E L+ + LLRE Q + EA+A
Sbjct: 1304 GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE---QYEEETEAKAELQRV 1360
Query: 180 --------------MELEALARAEKAGRAE---AEGLRAALAGAEVVR---KNLEEGSQR 219
E +A+ R E+ A+ A+ L+ A E V +LE+ R
Sbjct: 1361 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHR 1420
Query: 220 ELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAE 279
E++ L + + A ++L K +K L+ + + EL +Q+EA
Sbjct: 1421 LQNEIEDLMVD-----VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1475
Query: 280 LLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDS 339
L +L K + E + +E ++ + + E+ T +L +T+ L++ R
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRE-NKNLQEEISDLTEQLGSSG--KTIHELEKVRKQ 1532
Query: 340 LHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKC--------QSLLNRWR 391
L A LQ ++ L +E ++ R + ++ E RK Q+ N R
Sbjct: 1533 LEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLR 1592
Query: 392 EKVFALMVQLKAQELEHSDSVKQLKGQVASLQE---------KVTSQSQEQAILQRSLQD 442
V +L L A+ +++++ K L E ++ +++Q+Q +SLQ
Sbjct: 1593 V-VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQV---KSLQS 1648
Query: 443 KAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAK 502
+ +++ A +L R + E+LR VV S+ E + +
Sbjct: 1649 LLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIE 1708
Query: 503 VEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKL--ALAQLRQESCPLPPPVTDVSLELQQ 560
L S N L +K+ + ++ A+ + R +TD ++ ++
Sbjct: 1709 TSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEE 1768
Query: 561 LREERN------RLDAELQLSARLIQQEVGRARE----QGEAERQQLSKVAQQLEQELQQ 610
L++E++ R+ ++ + + +Q + A + G+ + Q+L ++LE EL+
Sbjct: 1769 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEA 1828
Query: 611 TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYG------QALQEKVAEVETR 664
Q+ A + + + +E T + R+ L + Q+L +A + + E E +
Sbjct: 1829 EQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888
Query: 665 LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
LS + +E +A ++ Q+ + A+ ++
Sbjct: 1889 ANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRD 1926
Score = 50.8 bits (120), Expect = 5e-06
Identities = 71/313 (22%), Positives = 131/313 (41%), Gaps = 39/313 (12%)
Query: 134 LEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAG- 192
L + ++ +A+ V+ LQ L L++T +Q + A E +A E+
Sbjct: 1629 LSHANRMAAEAQKQVKSLQSL---------LKDTQIQLDDAVRANDDLKENIAIVERRNN 1679
Query: 193 --RAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQE-------------QLSSLTQ 237
+AE E LRA + E RK E+ E VQ LH + LS L
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739
Query: 238 AHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVT 297
EEA+ + E +K+++ A E K+ + E ++K + +T +DL+ ++
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITD-AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLD 1798
Query: 298 LVENLRKYVGEQVPSEVHSQTWELERQKLLETMQHLQE---DRDSLHATAELLQVRVQSL 354
E + G++ ++ ++ ELE + E ++ + R S EL +
Sbjct: 1799 EAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDR 1858
Query: 355 THILALQE--EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSV 412
++L LQ+ ++L KV+ E + + L+++R+ VQ + E E +
Sbjct: 1859 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK------VQHELDEAEERADI 1912
Query: 413 KQLKGQVASLQEK 425
+ QV L+ K
Sbjct: 1913 AE--SQVNKLRAK 1923
Score = 39.3 bits (90), Expect = 0.015
Identities = 50/215 (23%), Positives = 85/215 (39%), Gaps = 23/215 (10%)
Query: 605 EQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETR 664
E+E+ +E L LE + ++E E+ SL QE Q L QA Q+ +A
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQ-LQVQAEQDNLA----- 899
Query: 665 LREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQRLAR 724
D E R ++ + + ++++ R E+E + EL ++ ++E L R
Sbjct: 900 ------DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAEL-TAKKRKLEDECSELKR 952
Query: 725 RLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSL------LDKKKSVVSSPRPPECS 778
+ +LE L LA +++E + K + L + L L K+K +
Sbjct: 953 DIDDLE----LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Query: 779 ASAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISK 813
V T K L +DDL+ E K
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 103 bits (258), Expect = 5e-22
Identities = 151/743 (20%), Positives = 305/743 (41%), Gaps = 115/743 (15%)
Query: 116 RDVSSDRQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRET------SL 169
R + + + R ++ S+ ++Q E L+ LE + +LR+ +
Sbjct: 424 RQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENR 483
Query: 170 QQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQ 229
+ K+R+ AQ L+ + ++ R E L ++ + R+ S L +
Sbjct: 484 ELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSY--------LSK 535
Query: 230 EQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKT- 288
Q+SS + + + E + +S L + A KE + A L QLS++
Sbjct: 536 YQMSSFSNKEDRCIGC----CEANKLVISELRIKLA--IKEAEIQKLHANLTANQLSQSL 589
Query: 289 ------QEDLEAQVTLVENLRKYVGEQVPSEVHSQT-------WELERQKLLETMQHLQE 335
QE + E + K G QV V Q +E ERQ+L+ ++ L+
Sbjct: 590 ITCNDSQESSKLSSLETEPV-KLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRT 648
Query: 336 DRDSLHATAELLQVRVQSLTHILALQEEELTRKVQPSDSLEPEFTRKCQSLL---NRWRE 392
+ A L+V + T L +EEL K S LE E T+KC LL + E
Sbjct: 649 KLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708
Query: 393 KVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERM 452
K+ A + A+ E + + ++ SL+ + ++ ++ + +KA ++ +E+
Sbjct: 709 KIVAYS-SIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL----AFEKAKKIHLEQ- 762
Query: 453 GAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPS 512
K ++ ++ R + + QQ E+ + ++ + Q LE+ + + ++
Sbjct: 763 -HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKK 821
Query: 513 LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAEL 572
N + A++ L V++ +++++Q LD+ L
Sbjct: 822 ENMKKDEALK-----------------------ALQNQVSEETIKVRQ-------LDSAL 851
Query: 573 QLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQES 632
++ +E+ QL ++ E++L++ E + L +L++ QE+
Sbjct: 852 EI-----------CKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQET 900
Query: 633 TEEAASLRQELTQQQELYGQAL--QEKVAEVETRLREQLSDTERRLNEARREHAKAVVSL 690
+E+ L+ L QQQ++ Q ++ + +T+L +Q+S E+ L + R A+ + +
Sbjct: 901 SEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKM 960
Query: 691 RQIQRRAAQEKE-RSQELRRLQEEAR---------KEEGQRLARRLQELERD-KNLMLAT 739
+ AA E + + Q++ L AR KEE ++ + + L+RD +N +
Sbjct: 961 EEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL 1020
Query: 740 LQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIK----- 794
Q + +L + K + L+KK + V + S + A+ RE ++
Sbjct: 1021 SQLDMILDQTKTE---------LEKKTNAVKELEKLQHSTETELTEALQKREVLETELQN 1071
Query: 795 --GSLSVLLDDLQDLSEAISKEE 815
G L L LQ+L + + K +
Sbjct: 1072 AHGELKSTLRQLQELRDVLQKAQ 1094
Score = 77.8 bits (190), Expect = 4e-14
Identities = 141/657 (21%), Positives = 271/657 (41%), Gaps = 89/657 (13%)
Query: 143 QAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAA 202
Q ++I +Q LE RLL E+ + K + L+AL + L +A
Sbjct: 795 QQDIICKQ----HHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSA 850
Query: 203 LAGAE---VVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEALSSLTSKAEG---LEKS 256
L + V+ N EG++ + E+ + E++ L + + SL +E L+ +
Sbjct: 851 LEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHT 910
Query: 257 LSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQ-VTLVENLRKYVGEQVPSEVH 315
L + E E + L KQ+SK +++L+ Q + E LRK + E+ S H
Sbjct: 911 LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK-MEEKCESAAH 969
Query: 316 SQTWELERQKLLET-----------------MQHLQEDRDSLHATAELLQVRVQSLTHIL 358
+L+RQK++E + ++++ L E + + L IL
Sbjct: 970 EA--DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMIL 1027
Query: 359 ALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQ 418
+ EL +K LE + ++ L +K L +L+ E +++QL+ +
Sbjct: 1028 DQTKTELEKKTNAVKELE-KLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQ-E 1085
Query: 419 VASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASA 478
+ + +K +E+ + L + E ++E K LE+ +A + R +Q A+
Sbjct: 1086 LRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQ 1145
Query: 479 EEQLRLVVNA----VSSSQIWLETTMAKVE----GAAAQLPSLNNRLSYAVRKVHTIRGL 530
L + + + I LE T+ K E Q+ SLN++L A ++
Sbjct: 1146 VTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQL------ 1199
Query: 531 IARKLALAQLRQESCPLPPPVTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQG 590
R+ L+ E E+ QL++E R ++ + V + +EQ
Sbjct: 1200 --REKEFIMLQNEQ------------EISQLKKEIERTQQRMKE-----MESVMKEQEQY 1240
Query: 591 EAERQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQE------LT 644
A + K A L QEL+ T+E + + +L AR Q ++ E L E L+
Sbjct: 1241 IATQY---KEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLS 1297
Query: 645 QQQELYGQALQEKV-------AEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRR- 696
++++ +G L E++ A +E R++ ++ + + + ++S ++ +
Sbjct: 1298 KEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKW 1357
Query: 697 ---AAQEKERSQELRRLQEEAR--KEEGQRLARRLQELERDKNLMLATLQQEGLLSR 748
A +K Q+L E+A+ EE Q L + +D+N ++ E LL++
Sbjct: 1358 KISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEA-ANEALLTK 1413
Score = 42.0 bits (97), Expect = 0.002
Identities = 68/330 (20%), Positives = 138/330 (41%), Gaps = 45/330 (13%)
Query: 418 QVASLQEKVTSQSQEQAIL---QRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 474
++ SL+EK+ Q+ A L SL K + E ++ L AQ QQ
Sbjct: 230 EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQ-------QQ 282
Query: 475 TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 534
AS ++N LE A+V L N+L + + V I ++
Sbjct: 283 AASVPILEEQIIN--------LE---AEVSAQDKVLREAENKLEQSQKMV------IEKE 325
Query: 535 LALAQLRQESCPLPPPVTDVSLELQQLREERNRL---DAELQLSARLIQQEVGRAREQGE 591
+L + ++E L + + + + ++ +RN EL + + +++V E+ +
Sbjct: 326 QSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQ 385
Query: 592 AERQQLSKVAQQLEQELQQTQESLASLGLQLEV----ARQGQQESTEEAASLRQELTQQQ 647
AE + L + E+E ++ QE +LE+ RQ ++E+ LR +
Sbjct: 386 AEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNS 445
Query: 648 ELYGQALQ--EKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQ 705
E+ Q + + + ++E+ L + +E R+ + R+++ R A + ER
Sbjct: 446 EVMAQLTESRQSILKLESELENK--------DEILRDKFSLMNENRELKVRVAAQNER-L 496
Query: 706 ELRRLQEEARKEEGQRLARRLQELERDKNL 735
+L + + E+ + E + L + + +L + L
Sbjct: 497 DLCQQEIESSRVELRSLEKIISQLPLKREL 526
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 103 bits (257), Expect = 7e-22
Identities = 151/687 (21%), Positives = 287/687 (41%), Gaps = 88/687 (12%)
Query: 122 RQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELR-RLEEEVRLLRETSLQQKMRLEAQAM 180
RQE + + L+ ++ Q+AE +++L++ +L EE LL+E LQ + L A+A
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAE 907
Query: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 240
E+ A+K + L L E + E+ Q+ E +++ Q+ L Q E
Sbjct: 908 EMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 241 E--ALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL 298
E A L + E + LE + + +E +LL +++S +L +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 299 VENLRKYVGEQVPS----EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL 354
+NL K + EV + E RQ+L + + L+ D H LQ ++ L
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 355 THILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSV 412
LA +EEEL + L+ E +K +L + + L L ++ + +
Sbjct: 1082 KMQLAKKEEELQAALA---RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 413 KQLK-----------------GQVASLQEKVTSQSQEQAILQRSLQD--KAAEVEVERMG 453
KQ + A+ QE + QE +L+++L + ++ E +V+ M
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 454 AKGL--------QLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVE 504
K QLE + +A +QT E L + + ++ +E K+E
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 505 GAAAQLPS-----------LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTD 553
+L S LN+++ +V ++ G+ L + ++ L V
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM------LNEAEGKAIKLAKDVAS 1312
Query: 554 VSLEL---QQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQQLEQE 607
+S +L Q+L +E R + R +++E ++Q + E +Q L + L +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 608 LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 667
L +++ L +E +G++ +E +L Q+ ++ Y +K+ + + RL++
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQQ 1427
Query: 668 QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEEGQ--R 721
+L D L+ R+ + R+ + A+EK S E R + EAR++E +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 722 LARRL-------QELERDKNLMLATLQ 741
LAR L +ELER ++ A ++
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME 1514
Score = 100 bits (249), Expect = 6e-21
Identities = 154/730 (21%), Positives = 311/730 (42%), Gaps = 108/730 (14%)
Query: 154 LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKN 212
L RL++E+ + +L++ LE +L+ +E+A R +AE + L E ++
Sbjct: 1096 LARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Query: 213 LEE-----GSQREL---------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEG 252
LE+ +Q+EL +E R H+ Q+ + Q H +A+ LT + E
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 253 LEKSLSSLETRR----------AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
+++ ++L+ + AGE + L +A++E E +K+L ++L+++ + E
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 303 RKYVGEQV---PSEVHSQTWELERQ--KLLETMQHLQEDRDSLHATAELLQVRVQSLTHI 357
R + ++V +EV S T L K ++ + + L T ELLQ + ++
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 358 LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLK- 416
+L + + +SL+ + + ++ N R + L +QL SDS K+L+
Sbjct: 1335 ----STKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQL-------SDSKKKLQD 1382
Query: 417 --GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 474
V +L+E +E L + ++KAA + LQ EL
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL----------DDL 1432
Query: 475 TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 534
+ Q +LV N + Q + +A+ + +++ +R R+ T +AR
Sbjct: 1433 VVDLDNQRQLVSN-LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 535 LALAQLRQESCPLPPPVTDVSLE-LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 593
L A +E + +E L +++ + EL+ S R + E +
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-----------ETQ 1540
Query: 594 RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQE 648
+++ ++LE ELQ T+++ L + ++ A +GQ Q E+ R++L +Q
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 649 LYGQALQEK------VAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
Y L+++ A + +L L D E + + A + +A+ LR++Q + +
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 703 RSQELRRLQEE--ARKEEGQRLARRLQ----ELERDKNLMLATLQQEGLLSRYKQQRLLT 756
++ R ++E A +E ++ A+ L+ +L+ D LA ++ + +++ L
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAAAERARKQADLEKEELAE 1715
Query: 757 VLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSE 809
L S L + ++ R E A +A E +G++ + D + LS
Sbjct: 1716 ELASSLSGRNALQDEKRRLE----ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 810 AISKEEAVCQ 819
++ E + Q
Sbjct: 1772 ELATERSTAQ 1781
Score = 91.7 bits (226), Expect = 3e-18
Identities = 149/618 (24%), Positives = 261/618 (42%), Gaps = 101/618 (16%)
Query: 150 QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 209
+++ + LE + L K +L+ A +EAL +K + E E L
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 210 RKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 264
LE+ R +E+ L +Q QL S + + L ++ + + + R
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 265 AGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQ 317
EA+E LA A EA +++L +T + L+A++ + + + VG+ V E+
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV-HELEKS 1533
Query: 318 TWELERQKLLETMQHLQEDRDSLHATAEL---LQVRVQSLTHILALQEEELTRKVQPSDS 374
LE Q + E L+E D L AT + L+V +Q+L + + R +Q D
Sbjct: 1534 KRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQAL-------KGQFERDLQARDE 1585
Query: 375 LEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTS--QSQE 432
E R+ Q L+ + + + + Q + + K+L+G + L+ + S + +E
Sbjct: 1586 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 433 QAILQ-RSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSS 491
+AI Q R LQ + K Q EL A+ +R + A+A+E +
Sbjct: 1642 EAIKQLRKLQAQM----------KDFQRELEDARASR---DEIFATAKENEK-------- 1680
Query: 492 SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 551
K + A L L L+ A R ARK A L +E
Sbjct: 1681 ----------KAKSLEADLMQLQEDLAAAER---------ARKQA--DLEKE-------- 1711
Query: 552 TDVSLELQQLREERNRL-DAELQLSARLIQQEVGRAREQG--EAERQQLSKVAQQLEQEL 608
+++ EL RN L D + +L AR+ Q E EQG EA ++ K QQ EQ L
Sbjct: 1712 -ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ-L 1769
Query: 609 QQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQ----ALQEKVAEVETR 664
+ S + E ARQ + +E S E+ + + AL+ K+A++E +
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 665 LREQLSDTERRLNEARREHAKAVVSLRQIQ---RRAAQEKERSQ-------ELRRLQEEA 714
+ ++ + + +++ K L Q++ + A Q KE+++ +L+R EEA
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 715 RKEEGQRLARRLQELERD 732
+EE QR+ ++L+R+
Sbjct: 1890 -EEESQRINANRRKLQRE 1906
Score = 57.8 bits (138), Expect = 4e-08
Identities = 82/344 (23%), Positives = 139/344 (40%), Gaps = 53/344 (15%)
Query: 128 RGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE---- 183
+GR ++ + L Q + R+L++ R +E+ + + ++ LEA M+L+
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 184 ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEAL 243
A RA K E E L LA + R L++ +R + +L +E Q + EA+
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE--QGNMEAM 1755
Query: 244 SSLTSKAEGLEKSLSS-LETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
S KA + LS+ L T R+ K E R+QL + ++L +++ +E
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGA 1807
Query: 303 RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 362
K + + + ++ +LE Q QE R+ AT L Q + + L IL E
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQV-------EQEAREKQAATKSLKQ-KDKKLKEILLQVE 1859
Query: 363 EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 422
+E RK + Q K Q + + VKQLK Q+
Sbjct: 1860 DE--RK----------------------------MAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 423 QEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQE 466
+E+ + + LQR L + E L+ +L R E
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 15/225 (6%)
Query: 602 QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA--LQEKVA 659
Q E ELQ+T+E +L+ Q + TEE L+++L + ELY +A ++ ++A
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 660 EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 719
+ L E L + E RL E Q+ A+ K+ +Q++ L+E+ +EE
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRG----------QQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 720 QRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSA 779
R +L+++ + + ++ +L Q L+ LL+++ S +++ E
Sbjct: 965 ARQKLQLEKVTAEAKIKKL---EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 780 SAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLD 824
+ + ES+ L V L + + + K + +GD D
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Score = 52.8 bits (125), Expect = 1e-06
Identities = 68/274 (24%), Positives = 118/274 (43%), Gaps = 37/274 (13%)
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
QL EE+N L +LQ L E R + A++Q+L ++ ++E L++ ++
Sbjct: 884 QLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEEDR--GQQ 940
Query: 620 LQLEVARQGQQ-----ESTEEAASLRQELTQQQ--------ELYGQAL-----QEKVAEV 661
LQ E + QQ E EE + RQ+L ++ +L + L K+++
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000
Query: 662 ETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQR 721
L E++SD L E E AK + L+ E E +R +EE ++E ++
Sbjct: 1001 RKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELE----VRLKKEEKSRQELEK 1055
Query: 722 LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASA 781
L R+L+ D + +A LQ + ++ K Q L KK+ + + A
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQ--IAELKMQ---------LAKKEEELQAALARLDDEIA 1104
Query: 782 PVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 815
A+ ++G +S L +DL A +K E
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 103 bits (257), Expect = 7e-22
Identities = 151/687 (21%), Positives = 287/687 (41%), Gaps = 88/687 (12%)
Query: 122 RQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELR-RLEEEVRLLRETSLQQKMRLEAQAM 180
RQE + + L+ ++ Q+AE +++L++ +L EE LL+E LQ + L A+A
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAE 914
Query: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 240
E+ A+K + L L E + E+ Q+ E +++ Q+ L Q E
Sbjct: 915 EMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 241 E--ALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL 298
E A L + E + LE + + +E +LL +++S +L +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 299 VENLRKYVGEQVPS----EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL 354
+NL K + EV + E RQ+L + + L+ D H LQ ++ L
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 355 THILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSV 412
LA +EEEL + L+ E +K +L + + L L ++ + +
Sbjct: 1089 KMQLAKKEEELQAALA---RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 413 KQLK-----------------GQVASLQEKVTSQSQEQAILQRSLQD--KAAEVEVERMG 453
KQ + A+ QE + QE +L+++L + ++ E +V+ M
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 454 AKGL--------QLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVE 504
K QLE + +A +QT E L + + ++ +E K+E
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 505 GAAAQLPS-----------LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTD 553
+L S LN+++ +V ++ G+ L + ++ L V
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM------LNEAEGKAIKLAKDVAS 1319
Query: 554 VSLEL---QQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQQLEQE 607
+S +L Q+L +E R + R +++E ++Q + E +Q L + L +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 608 LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 667
L +++ L +E +G++ +E +L Q+ ++ Y +K+ + + RL++
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQQ 1434
Query: 668 QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEEGQ--R 721
+L D L+ R+ + R+ + A+EK S E R + EAR++E +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 722 LARRL-------QELERDKNLMLATLQ 741
LAR L +ELER ++ A ++
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME 1521
Score = 100 bits (249), Expect = 6e-21
Identities = 154/730 (21%), Positives = 311/730 (42%), Gaps = 108/730 (14%)
Query: 154 LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKN 212
L RL++E+ + +L++ LE +L+ +E+A R +AE + L E ++
Sbjct: 1103 LARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Query: 213 LEE-----GSQREL---------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEG 252
LE+ +Q+EL +E R H+ Q+ + Q H +A+ LT + E
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 253 LEKSLSSLETRR----------AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
+++ ++L+ + AGE + L +A++E E +K+L ++L+++ + E
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 303 RKYVGEQV---PSEVHSQTWELERQ--KLLETMQHLQEDRDSLHATAELLQVRVQSLTHI 357
R + ++V +EV S T L K ++ + + L T ELLQ + ++
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 358 LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLK- 416
+L + + +SL+ + + ++ N R + L +QL SDS K+L+
Sbjct: 1342 ----STKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQL-------SDSKKKLQD 1389
Query: 417 --GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 474
V +L+E +E L + ++KAA + LQ EL
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL----------DDL 1439
Query: 475 TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 534
+ Q +LV N + Q + +A+ + +++ +R R+ T +AR
Sbjct: 1440 VVDLDNQRQLVSN-LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 535 LALAQLRQESCPLPPPVTDVSLE-LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 593
L A +E + +E L +++ + EL+ S R + E +
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-----------ETQ 1547
Query: 594 RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQE 648
+++ ++LE ELQ T+++ L + ++ A +GQ Q E+ R++L +Q
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 649 LYGQALQEK------VAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
Y L+++ A + +L L D E + + A + +A+ LR++Q + +
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 703 RSQELRRLQEE--ARKEEGQRLARRLQ----ELERDKNLMLATLQQEGLLSRYKQQRLLT 756
++ R ++E A +E ++ A+ L+ +L+ D LA ++ + +++ L
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAAAERARKQADLEKEELAE 1722
Query: 757 VLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSE 809
L S L + ++ R E A +A E +G++ + D + LS
Sbjct: 1723 ELASSLSGRNALQDEKRRLE----ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 810 AISKEEAVCQ 819
++ E + Q
Sbjct: 1779 ELATERSTAQ 1788
Score = 91.7 bits (226), Expect = 3e-18
Identities = 149/618 (24%), Positives = 261/618 (42%), Gaps = 101/618 (16%)
Query: 150 QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 209
+++ + LE + L K +L+ A +EAL +K + E E L
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 210 RKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 264
LE+ R +E+ L +Q QL S + + L ++ + + + R
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 265 AGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQ 317
EA+E LA A EA +++L +T + L+A++ + + + VG+ V E+
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV-HELEKS 1540
Query: 318 TWELERQKLLETMQHLQEDRDSLHATAEL---LQVRVQSLTHILALQEEELTRKVQPSDS 374
LE Q + E L+E D L AT + L+V +Q+L + + R +Q D
Sbjct: 1541 KRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQAL-------KGQFERDLQARDE 1592
Query: 375 LEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTS--QSQE 432
E R+ Q L+ + + + + Q + + K+L+G + L+ + S + +E
Sbjct: 1593 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 433 QAILQ-RSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQTASAEEQLRLVVNAVSS 491
+AI Q R LQ + K Q EL A+ +R + A+A+E +
Sbjct: 1649 EAIKQLRKLQAQM----------KDFQRELEDARASR---DEIFATAKENEK-------- 1687
Query: 492 SQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPV 551
K + A L L L+ A R ARK A L +E
Sbjct: 1688 ----------KAKSLEADLMQLQEDLAAAER---------ARKQA--DLEKE-------- 1718
Query: 552 TDVSLELQQLREERNRL-DAELQLSARLIQQEVGRAREQG--EAERQQLSKVAQQLEQEL 608
+++ EL RN L D + +L AR+ Q E EQG EA ++ K QQ EQ L
Sbjct: 1719 -ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ-L 1776
Query: 609 QQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQ----ALQEKVAEVETR 664
+ S + E ARQ + +E S E+ + + AL+ K+A++E +
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 665 LREQLSDTERRLNEARREHAKAVVSLRQIQ---RRAAQEKERSQ-------ELRRLQEEA 714
+ ++ + + +++ K L Q++ + A Q KE+++ +L+R EEA
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Query: 715 RKEEGQRLARRLQELERD 732
+EE QR+ ++L+R+
Sbjct: 1897 -EEESQRINANRRKLQRE 1913
Score = 57.8 bits (138), Expect = 4e-08
Identities = 82/344 (23%), Positives = 139/344 (40%), Gaps = 53/344 (15%)
Query: 128 RGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE---- 183
+GR ++ + L Q + R+L++ R +E+ + + ++ LEA M+L+
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 184 ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEAL 243
A RA K E E L LA + R L++ +R + +L +E Q + EA+
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE--QGNMEAM 1762
Query: 244 SSLTSKAEGLEKSLSS-LETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
S KA + LS+ L T R+ K E R+QL + ++L +++ +E
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGA 1814
Query: 303 RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 362
K + + + ++ +LE Q QE R+ AT L Q + + L IL E
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQV-------EQEAREKQAATKSLKQ-KDKKLKEILLQVE 1866
Query: 363 EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 422
+E RK + Q K Q + + VKQLK Q+
Sbjct: 1867 DE--RK----------------------------MAEQYKEQAEKGNARVKQLKRQLEEA 1896
Query: 423 QEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQE 466
+E+ + + LQR L + E L+ +L R E
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 15/225 (6%)
Query: 602 QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA--LQEKVA 659
Q E ELQ+T+E +L+ Q + TEE L+++L + ELY +A ++ ++A
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 660 EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 719
+ L E L + E RL E Q+ A+ K+ +Q++ L+E+ +EE
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRG----------QQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 720 QRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSA 779
R +L+++ + + ++ +L Q L+ LL+++ S +++ E
Sbjct: 972 ARQKLQLEKVTAEAKIKKL---EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 780 SAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLD 824
+ + ES+ L V L + + + K + +GD D
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Score = 52.8 bits (125), Expect = 1e-06
Identities = 68/274 (24%), Positives = 118/274 (43%), Gaps = 37/274 (13%)
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
QL EE+N L +LQ L E R + A++Q+L ++ ++E L++ ++
Sbjct: 891 QLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEEDR--GQQ 947
Query: 620 LQLEVARQGQQ-----ESTEEAASLRQELTQQQ--------ELYGQAL-----QEKVAEV 661
LQ E + QQ E EE + RQ+L ++ +L + L K+++
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007
Query: 662 ETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQR 721
L E++SD L E E AK + L+ E E +R +EE ++E ++
Sbjct: 1008 RKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELE----VRLKKEEKSRQELEK 1062
Query: 722 LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASA 781
L R+L+ D + +A LQ + ++ K Q L KK+ + + A
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQ--IAELKMQ---------LAKKEEELQAALARLDDEIA 1111
Query: 782 PVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 815
A+ ++G +S L +DL A +K E
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 103 bits (257), Expect = 7e-22
Identities = 151/687 (21%), Positives = 287/687 (41%), Gaps = 88/687 (12%)
Query: 122 RQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELR-RLEEEVRLLRETSLQQKMRLEAQAM 180
RQE + + L+ ++ Q+AE +++L++ +L EE LL+E LQ + L A+A
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAE 914
Query: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 240
E+ A+K + L L E + E+ Q+ E +++ Q+ L Q E
Sbjct: 915 EMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968
Query: 241 E--ALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL 298
E A L + E + LE + + +E +LL +++S +L +
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 299 VENLRKYVGEQVPS----EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL 354
+NL K + EV + E RQ+L + + L+ D H LQ ++ L
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 355 THILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSV 412
LA +EEEL + L+ E +K +L + + L L ++ + +
Sbjct: 1089 KMQLAKKEEELQAALA---RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 413 KQLK-----------------GQVASLQEKVTSQSQEQAILQRSLQD--KAAEVEVERMG 453
KQ + A+ QE + QE +L+++L + ++ E +V+ M
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 454 AKGL--------QLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVE 504
K QLE + +A +QT E L + + ++ +E K+E
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 505 GAAAQLPS-----------LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTD 553
+L S LN+++ +V ++ G+ L + ++ L V
Sbjct: 1266 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM------LNEAEGKAIKLAKDVAS 1319
Query: 554 VSLEL---QQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQQLEQE 607
+S +L Q+L +E R + R +++E ++Q + E +Q L + L +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 608 LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 667
L +++ L +E +G++ +E +L Q+ ++ Y +K+ + + RL++
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQQ 1434
Query: 668 QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEEGQ--R 721
+L D L+ R+ + R+ + A+EK S E R + EAR++E +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494
Query: 722 LARRL-------QELERDKNLMLATLQ 741
LAR L +ELER ++ A ++
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME 1521
Score = 100 bits (249), Expect = 6e-21
Identities = 154/730 (21%), Positives = 311/730 (42%), Gaps = 108/730 (14%)
Query: 154 LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKN 212
L RL++E+ + +L++ LE +L+ +E+A R +AE + L E ++
Sbjct: 1103 LARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1161
Query: 213 LEE-----GSQREL---------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEG 252
LE+ +Q+EL +E R H+ Q+ + Q H +A+ LT + E
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 253 LEKSLSSLETRR----------AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
+++ ++L+ + AGE + L +A++E E +K+L ++L+++ + E
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 303 RKYVGEQV---PSEVHSQTWELERQ--KLLETMQHLQEDRDSLHATAELLQVRVQSLTHI 357
R + ++V +EV S T L K ++ + + L T ELLQ + ++
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 358 LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLK- 416
+L + + +SL+ + + ++ N R + L +QL SDS K+L+
Sbjct: 1342 ----STKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQL-------SDSKKKLQD 1389
Query: 417 --GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 474
V +L+E +E L + ++KAA + LQ EL
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL----------DDL 1439
Query: 475 TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 534
+ Q +LV N + Q + +A+ + +++ +R R+ T +AR
Sbjct: 1440 VVDLDNQRQLVSN-LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 535 LALAQLRQESCPLPPPVTDVSLE-LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 593
L A +E + +E L +++ + EL+ S R + E +
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-----------ETQ 1547
Query: 594 RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQE 648
+++ ++LE ELQ T+++ L + ++ A +GQ Q E+ R++L +Q
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 649 LYGQALQEK------VAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
Y L+++ A + +L L D E + + A + +A+ LR++Q + +
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 703 RSQELRRLQEE--ARKEEGQRLARRLQ----ELERDKNLMLATLQQEGLLSRYKQQRLLT 756
++ R ++E A +E ++ A+ L+ +L+ D LA ++ + +++ L
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAAAERARKQADLEKEELAE 1722
Query: 757 VLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSE 809
L S L + ++ R E A +A E +G++ + D + LS
Sbjct: 1723 ELASSLSGRNALQDEKRRLE----ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 810 AISKEEAVCQ 819
++ E + Q
Sbjct: 1779 ELATERSTAQ 1788
Score = 93.2 bits (230), Expect = 9e-19
Identities = 138/607 (22%), Positives = 272/607 (44%), Gaps = 62/607 (10%)
Query: 150 QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 209
+++ + LE + L K +L+ A +EAL +K + E E L
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 210 RKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 264
LE+ R +E+ L +Q QL S + + L ++ + + + R
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 265 AGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQ 317
EA+E LA A EA +++L +T + L+A++ + + + VG+ V E+
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV-HELEKS 1540
Query: 318 TWELERQKLLETMQHLQEDRDSLHATAEL---LQVRVQSLTHILALQEEELTRKVQPSDS 374
LE Q + E L+E D L AT + L+V +Q+L + + R +Q D
Sbjct: 1541 KRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQAL-------KGQFERDLQARDE 1592
Query: 375 LEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTS--QSQE 432
E R+ Q L+ + + + + Q + + K+L+G + L+ + S + +E
Sbjct: 1593 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1648
Query: 433 QAILQ-RSLQDKAAEVEVERMGAKGLQLEL-SRAQEARRRWQQQTASAEEQLRLVVNAVS 490
+AI Q R LQ + + + E A+ + E+ + A+E ++ + A + ++L + +
Sbjct: 1649 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQEDLAA 1705
Query: 491 SSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPP 550
+ + + + K E A SL+ R + K R L AR +AQL +E
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEK----RRLEAR---IAQLEEELEEEQGN 1758
Query: 551 VTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQ 610
+ +S +++ ++ +L EL + R Q+ AR+Q E + ++L ++E ++
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELA-TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 611 TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLS 670
+S + L+ ++A+ +E E+ A +Q T+ + + L+E + +VE
Sbjct: 1818 KFKSTIA-ALEAKIAQL--EEQVEQEAREKQAATKSLKQKDKKLKEILLQVED------- 1867
Query: 671 DTERRLNEARREHA-KAVVSLRQIQRRAAQEKERSQEL----RRLQEEARK--EEGQRLA 723
ER++ E +E A K ++Q++R+ + +E SQ + R+LQ E + E + +
Sbjct: 1868 --ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1925
Query: 724 RRLQELE 730
R + L+
Sbjct: 1926 REVNALK 1932
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/318 (23%), Positives = 131/318 (41%), Gaps = 39/318 (12%)
Query: 128 RGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE---- 183
+GR ++ + L Q + R+L++ R +E+ + + ++ LEA M+L+
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1704
Query: 184 ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEAL 243
A RA K E E L LA + R L++ +R + +L +E Q + EA+
Sbjct: 1705 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE--QGNMEAM 1762
Query: 244 SSLTSKAEGLEKSLSS-LETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
S KA + LS+ L T R+ K E R+QL + ++L +++ +E
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGA 1814
Query: 303 RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 362
K + + + ++ +LE Q QE R+ AT L Q + + L IL E
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQV-------EQEAREKQAATKSLKQ-KDKKLKEILLQVE 1866
Query: 363 EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 422
+E RK EK A + QLK Q E + +++ L
Sbjct: 1867 DE----------------RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Query: 423 QEKVTSQSQEQAILQRSL 440
Q ++ ++ + R +
Sbjct: 1911 QRELDEATESNEAMGREV 1928
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 15/225 (6%)
Query: 602 QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA--LQEKVA 659
Q E ELQ+T+E +L+ Q + TEE L+++L + ELY +A ++ ++A
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 660 EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 719
+ L E L + E RL E Q+ A+ K+ +Q++ L+E+ +EE
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRG----------QQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 720 QRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSA 779
R +L+++ + + ++ +L Q L+ LL+++ S +++ E
Sbjct: 972 ARQKLQLEKVTAEAKIKKL---EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 780 SAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLD 824
+ + ES+ L V L + + + K + +GD D
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Score = 52.8 bits (125), Expect = 1e-06
Identities = 68/274 (24%), Positives = 118/274 (43%), Gaps = 37/274 (13%)
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
QL EE+N L +LQ L E R + A++Q+L ++ ++E L++ ++
Sbjct: 891 QLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEEDR--GQQ 947
Query: 620 LQLEVARQGQQ-----ESTEEAASLRQELTQQQ--------ELYGQAL-----QEKVAEV 661
LQ E + QQ E EE + RQ+L ++ +L + L K+++
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007
Query: 662 ETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQR 721
L E++SD L E E AK + L+ E E +R +EE ++E ++
Sbjct: 1008 RKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELE----VRLKKEEKSRQELEK 1062
Query: 722 LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASA 781
L R+L+ D + +A LQ + ++ K Q L KK+ + + A
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQ--IAELKMQ---------LAKKEEELQAALARLDDEIA 1111
Query: 782 PVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 815
A+ ++G +S L +DL A +K E
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 103 bits (257), Expect = 7e-22
Identities = 151/687 (21%), Positives = 287/687 (41%), Gaps = 88/687 (12%)
Query: 122 RQEPGRRGRSWGLEGSQALSQQAEVIVRQLQELR-RLEEEVRLLRETSLQQKMRLEAQAM 180
RQE + + L+ ++ Q+AE +++L++ +L EE LL+E LQ + L A+A
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE-QLQAETELYAEAE 907
Query: 181 ELEALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHE 240
E+ A+K + L L E + E+ Q+ E +++ Q+ L Q E
Sbjct: 908 EMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961
Query: 241 E--ALSSLTSKAEGLEKSLSSLETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTL 298
E A L + E + LE + + +E +LL +++S +L +
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 299 VENLRKYVGEQVPS----EVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSL 354
+NL K + EV + E RQ+L + + L+ D H LQ ++ L
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 355 THILALQEEELTRKVQPSDSLEPEFTRKCQSL--LNRWREKVFALMVQLKAQELEHSDSV 412
LA +EEEL + L+ E +K +L + + L L ++ + +
Sbjct: 1082 KMQLAKKEEELQAALA---RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 413 KQLK-----------------GQVASLQEKVTSQSQEQAILQRSLQD--KAAEVEVERMG 453
KQ + A+ QE + QE +L+++L + ++ E +V+ M
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 454 AKGL--------QLELSRAQEARRRWQQQTASAEE-QLRLVVNAVSSSQIWLETTMAKVE 504
K QLE + +A +QT E L + + ++ +E K+E
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 505 GAAAQLPS-----------LNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPPVTD 553
+L S LN+++ +V ++ G+ L + ++ L V
Sbjct: 1259 AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM------LNEAEGKAIKLAKDVAS 1312
Query: 554 VSLEL---QQLREERNRLDAELQLSARLIQQEVGRAREQGEAE---RQQLSKVAQQLEQE 607
+S +L Q+L +E R + R +++E ++Q + E +Q L + L +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 608 LQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLRE 667
L +++ L +E +G++ +E +L Q+ ++ Y +K+ + + RL++
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY-----DKLEKTKNRLQQ 1427
Query: 668 QLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERS----QELRRLQEEARKEEGQ--R 721
+L D L+ R+ + R+ + A+EK S E R + EAR++E +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487
Query: 722 LARRL-------QELERDKNLMLATLQ 741
LAR L +ELER ++ A ++
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME 1514
Score = 100 bits (249), Expect = 6e-21
Identities = 154/730 (21%), Positives = 311/730 (42%), Gaps = 108/730 (14%)
Query: 154 LRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGA-EVVRKN 212
L RL++E+ + +L++ LE +L+ +E+A R +AE + L E ++
Sbjct: 1096 LARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE 1154
Query: 213 LEE-----GSQREL---------------EEVQRLHQEQLSSLTQAHEEALSSLTSKAEG 252
LE+ +Q+EL +E R H+ Q+ + Q H +A+ LT + E
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 253 LEKSLSSLETRR----------AGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
+++ ++L+ + AGE + L +A++E E +K+L ++L+++ + E
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 303 RKYVGEQV---PSEVHSQTWELERQ--KLLETMQHLQEDRDSLHATAELLQVRVQSLTHI 357
R + ++V +EV S T L K ++ + + L T ELLQ + ++
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 358 LALQEEELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLK- 416
+L + + +SL+ + + ++ N R + L +QL SDS K+L+
Sbjct: 1335 ----STKLRQLEEERNSLQDQLDEEMEAKQNLERH-ISTLNIQL-------SDSKKKLQD 1382
Query: 417 --GQVASLQEKVTSQSQEQAILQRSLQDKAAEVEVERMGAKGLQLELSRAQEARRRWQQQ 474
V +L+E +E L + ++KAA + LQ EL
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL----------DDL 1432
Query: 475 TASAEEQLRLVVNAVSSSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARK 534
+ Q +LV N + Q + +A+ + +++ +R R+ T +AR
Sbjct: 1433 VVDLDNQRQLVSN-LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 535 LALAQLRQESCPLPPPVTDVSLE-LQQLREERNRLDAELQLSARLIQQEVGRAREQGEAE 593
L A +E + +E L +++ + EL+ S R + E +
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL-----------ETQ 1540
Query: 594 RQQLSKVAQQLEQELQQTQESLASLGLQLEVARQGQ-----QESTEEAASLRQELTQQQE 648
+++ ++LE ELQ T+++ L + ++ A +GQ Q E+ R++L +Q
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQ-ALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 649 LYGQALQEK------VAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKE 702
Y L+++ A + +L L D E + + A + +A+ LR++Q + +
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 703 RSQELRRLQEE--ARKEEGQRLARRLQ----ELERDKNLMLATLQQEGLLSRYKQQRLLT 756
++ R ++E A +E ++ A+ L+ +L+ D LA ++ + +++ L
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAAAERARKQADLEKEELAE 1715
Query: 757 VLPSLLDKKKSVVSSPRPPECSASAPVAAAVPTRESIKGSLSVLLD-------DLQDLSE 809
L S L + ++ R E A +A E +G++ + D + LS
Sbjct: 1716 ELASSLSGRNALQDEKRRLE----ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 810 AISKEEAVCQ 819
++ E + Q
Sbjct: 1772 ELATERSTAQ 1781
Score = 93.2 bits (230), Expect = 9e-19
Identities = 138/607 (22%), Positives = 272/607 (44%), Gaps = 62/607 (10%)
Query: 150 QLQELRRLEEEVRLLRETSLQQKMRLEAQAMELEALARAEKAGRAEAEGLRAALAGAEVV 209
+++ + LE + L K +L+ A +EAL +K + E E L
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 210 RKNLEEGSQRELEEVQRL-----HQEQLSSLTQAHEEALSSLTSKAEGLEKSLSSLETRR 264
LE+ R +E+ L +Q QL S + + L ++ + + + R
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 265 AGEAKE-------LAEAQREAELLRKQLSKTQEDLEAQVTLVENLRKYVGEQVPSEVHSQ 317
EA+E LA A EA +++L +T + L+A++ + + + VG+ V E+
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV-HELEKS 1533
Query: 318 TWELERQKLLETMQHLQEDRDSLHATAEL---LQVRVQSLTHILALQEEELTRKVQPSDS 374
LE Q + E L+E D L AT + L+V +Q+L + + R +Q D
Sbjct: 1534 KRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQAL-------KGQFERDLQARDE 1585
Query: 375 LEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASLQEKVTS--QSQE 432
E R+ Q L+ + + + + Q + + K+L+G + L+ + S + +E
Sbjct: 1586 QNEEKRRQLQRQLHEYETE----LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGRE 1641
Query: 433 QAILQ-RSLQDKAAEVEVERMGAKGLQLEL-SRAQEARRRWQQQTASAEEQLRLVVNAVS 490
+AI Q R LQ + + + E A+ + E+ + A+E ++ + A + ++L + +
Sbjct: 1642 EAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQEDLAA 1698
Query: 491 SSQIWLETTMAKVEGAAAQLPSLNNRLSYAVRKVHTIRGLIARKLALAQLRQESCPLPPP 550
+ + + + K E A SL+ R + K R L AR +AQL +E
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEK----RRLEAR---IAQLEEELEEEQGN 1751
Query: 551 VTDVSLELQQLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQ 610
+ +S +++ ++ +L EL + R Q+ AR+Q E + ++L ++E ++
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELA-TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 611 TQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQALQEKVAEVETRLREQLS 670
+S + L+ ++A+ +E E+ A +Q T+ + + L+E + +VE
Sbjct: 1811 KFKSTIA-ALEAKIAQL--EEQVEQEAREKQAATKSLKQKDKKLKEILLQVED------- 1860
Query: 671 DTERRLNEARREHA-KAVVSLRQIQRRAAQEKERSQEL----RRLQEEARK--EEGQRLA 723
ER++ E +E A K ++Q++R+ + +E SQ + R+LQ E + E + +
Sbjct: 1861 --ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMG 1918
Query: 724 RRLQELE 730
R + L+
Sbjct: 1919 REVNALK 1925
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/318 (23%), Positives = 131/318 (41%), Gaps = 39/318 (12%)
Query: 128 RGRSWGLEGSQALSQQAEVIVRQLQELRRLEEEVRLLRETSLQQKMRLEAQAMELE---- 183
+GR ++ + L Q + R+L++ R +E+ + + ++ LEA M+L+
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLA 1697
Query: 184 ALARAEKAGRAEAEGLRAALAGAEVVRKNLEEGSQRELEEVQRLHQEQLSSLTQAHEEAL 243
A RA K E E L LA + R L++ +R + +L +E Q + EA+
Sbjct: 1698 AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE--QGNMEAM 1755
Query: 244 SSLTSKAEGLEKSLSS-LETRRAGEAKELAEAQREAELLRKQLSKTQEDLEAQVTLVENL 302
S KA + LS+ L T R+ K E R+QL + ++L +++ +E
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKN--------ESARQQLERQNKELRSKLHEMEGA 1807
Query: 303 RKYVGEQVPSEVHSQTWELERQKLLETMQHLQEDRDSLHATAELLQVRVQSLTHILALQE 362
K + + + ++ +LE Q QE R+ AT L Q + + L IL E
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQV-------EQEAREKQAATKSLKQ-KDKKLKEILLQVE 1859
Query: 363 EELTRKVQPSDSLEPEFTRKCQSLLNRWREKVFALMVQLKAQELEHSDSVKQLKGQVASL 422
+E RK EK A + QLK Q E + +++ L
Sbjct: 1860 DE----------------RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Query: 423 QEKVTSQSQEQAILQRSL 440
Q ++ ++ + R +
Sbjct: 1904 QRELDEATESNEAMGREV 1921
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/225 (23%), Positives = 101/225 (44%), Gaps = 15/225 (6%)
Query: 602 QQLEQELQQTQESLASLGLQLEVARQGQQESTEEAASLRQELTQQQELYGQA--LQEKVA 659
Q E ELQ+T+E +L+ Q + TEE L+++L + ELY +A ++ ++A
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 660 EVETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEG 719
+ L E L + E RL E Q+ A+ K+ +Q++ L+E+ +EE
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRG----------QQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 720 QRLARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSA 779
R +L+++ + + ++ +L Q L+ LL+++ S +++ E
Sbjct: 965 ARQKLQLEKVTAEAKIKKL---EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 780 SAPVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEEAVCQGDNLD 824
+ + ES+ L V L + + + K + +GD D
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Score = 52.8 bits (125), Expect = 1e-06
Identities = 68/274 (24%), Positives = 118/274 (43%), Gaps = 37/274 (13%)
Query: 560 QLREERNRLDAELQLSARLIQQEVGRAREQGEAERQQLSKVAQQLEQELQQTQESLASLG 619
QL EE+N L +LQ L E R + A++Q+L ++ ++E L++ ++
Sbjct: 884 QLTEEKNLLQEQLQAETELYA-EAEEMRVRLAAKKQELEEILHEMEARLEEEEDR--GQQ 940
Query: 620 LQLEVARQGQQ-----ESTEEAASLRQELTQQQ--------ELYGQAL-----QEKVAEV 661
LQ E + QQ E EE + RQ+L ++ +L + L K+++
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000
Query: 662 ETRLREQLSDTERRLNEARREHAKAVVSLRQIQRRAAQEKERSQELRRLQEEARKEEGQR 721
L E++SD L E E AK + L+ E E +R +EE ++E ++
Sbjct: 1001 RKLLEERISDLTTNLAE-EEEKAKNLTKLKNKHESMISELE----VRLKKEEKSRQELEK 1055
Query: 722 LARRLQELERDKNLMLATLQQEGLLSRYKQQRLLTVLPSLLDKKKSVVSSPRPPECSASA 781
L R+L+ D + +A LQ + ++ K Q L KK+ + + A
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQ--IAELKMQ---------LAKKEEELQAALARLDDEIA 1104
Query: 782 PVAAAVPTRESIKGSLSVLLDDLQDLSEAISKEE 815
A+ ++G +S L +DL A +K E
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.125 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,700,725
Number of Sequences: 37866
Number of extensions: 1310191
Number of successful extensions: 23658
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 457
Number of HSP's successfully gapped in prelim test: 1219
Number of HSP's that attempted gapping in prelim test: 8021
Number of HSP's gapped (non-prelim): 6963
length of query: 835
length of database: 18,247,518
effective HSP length: 111
effective length of query: 724
effective length of database: 14,044,392
effective search space: 10168139808
effective search space used: 10168139808
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.