Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 156938336
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|156938336 class II transactivator [Homo sapiens]
(1130 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|156938336 class II transactivator [Homo sapiens] 2260 0.0
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 132 2e-30
gi|11545912 nucleotide-binding oligomerization domain containing... 124 4e-28
gi|5174617 nucleotide-binding oligomerization domain containing ... 119 1e-26
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 111 3e-24
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 106 1e-22
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 100 6e-21
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 100 6e-21
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 100 6e-21
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 99 3e-20
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 96 3e-19
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 96 3e-19
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 94 7e-19
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 94 7e-19
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 92 2e-18
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 79 3e-14
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 76 2e-13
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 76 2e-13
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 76 2e-13
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 76 2e-13
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 76 2e-13
gi|118918429 NOD3 protein [Homo sapiens] 76 2e-13
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 75 4e-13
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 71 5e-12
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 69 2e-11
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 62 2e-09
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 62 4e-09
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 56 2e-07
gi|25777608 NLR family member X1 isoform 1 [Homo sapiens] 56 2e-07
gi|25777610 NLR family member X1 isoform 2 [Homo sapiens] 56 2e-07
>gi|156938336 class II transactivator [Homo sapiens]
Length = 1130
Score = 2260 bits (5857), Expect = 0.0
Identities = 1130/1130 (100%), Positives = 1130/1130 (100%)
Query: 1 MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEE 60
MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEE
Sbjct: 1 MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEE 60
Query: 61 EIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFK 120
EIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFK
Sbjct: 61 EIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFK 120
Query: 121 HIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCS 180
HIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCS
Sbjct: 121 HIGPDEVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCS 180
Query: 181 TLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGL 240
TLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGL
Sbjct: 181 TLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGL 240
Query: 241 WQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSM 300
WQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSM
Sbjct: 241 WQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSM 300
Query: 301 PEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGIL 360
PEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGIL
Sbjct: 301 PEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGIL 360
Query: 361 VEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLG 420
VEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLG
Sbjct: 361 VEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLG 420
Query: 421 KAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAA 480
KAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAA
Sbjct: 421 KAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAA 480
Query: 481 DEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRG 540
DEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRG
Sbjct: 481 DEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRG 540
Query: 541 CTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRD 600
CTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRD
Sbjct: 541 CTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRD 600
Query: 601 RPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAEL 660
RPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAEL
Sbjct: 601 RPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAEL 660
Query: 661 AKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGAL 720
AKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGAL
Sbjct: 661 AKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGAL 720
Query: 721 WLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAA 780
WLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAA
Sbjct: 721 WLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAA 780
Query: 781 SVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRL 840
SVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRL
Sbjct: 781 SVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRL 840
Query: 841 TPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQ 900
TPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQ
Sbjct: 841 TPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQ 900
Query: 901 QHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKL 960
QHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKL
Sbjct: 901 QHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKL 960
Query: 961 EFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETL 1020
EFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETL
Sbjct: 961 EFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETL 1020
Query: 1021 NLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQ 1080
NLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQ
Sbjct: 1021 NLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQ 1080
Query: 1081 YNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR 1130
YNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR
Sbjct: 1081 YNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR 1130
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 132 bits (331), Expect = 2e-30
Identities = 169/605 (27%), Positives = 241/605 (39%), Gaps = 68/605 (11%)
Query: 414 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLG 473
RV +LGKAG GK+ A + + WA G L + +F LN +LLF L
Sbjct: 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLY 281
Query: 474 PQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLF 533
P D VF ++ K D+VLLI DG +E G P P + L + L
Sbjct: 282 LSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMG---------PDGPGPVLTLFSHLC 332
Query: 534 QKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDR 593
LL GC ++ T+RP G+L L A+ + GF + + YV +F + E
Sbjct: 333 NGTLLPGCRVMATSRP-GKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREG--- 388
Query: 594 ALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLE---LGEDAKLPSTLTGLYVGLLGRAAL 650
AL L+ L S P LC+ C LL G+ L +T LY+ ++ AL
Sbjct: 389 ALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMV--LAL 446
Query: 651 DSPPGALAELAKLAWELGRRHQSTLQEDQ--FPSADVRTWAMAKGLVQH---------PP 699
SPPG L + L +LG L+ + F + D+ +A G P
Sbjct: 447 -SPPGHLPTSSLL--DLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGP 503
Query: 700 RAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPR---KKRPYDNWLEGVPR 756
++ AF LQ FL AL L S ++ L QY+ L R + + + +P
Sbjct: 504 GHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRTKARLGLSDHLPT 563
Query: 757 FLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEA 816
FLAGL R + L V KQ + + LK+L L +++EL HC E
Sbjct: 564 FLAGLA-SCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTGPKVVELCHCVDET 622
Query: 817 EEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGI---CPS-- 871
+E + Q LP +L F LT D L LE LD + CP
Sbjct: 623 QEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDGCPLEPHCPEAL 682
Query: 872 -GLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVED 930
G G + LS +R + + AL SL G ++L A K T
Sbjct: 683 VGCGQIENLSFKSR-KCGDAFAEALSRSLPTMGRLQMLGLAGSKIT-----------ARG 730
Query: 931 LGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLD 990
+ LV+ LP LK++ F +S Q +V +L L+ LD
Sbjct: 731 ISHLVKA-------------LPLCPQLKEVSFRDNQLS-DQVVLNIVEVLPHLPRLRKLD 776
Query: 991 LDALS 995
L + S
Sbjct: 777 LSSNS 781
Score = 70.5 bits (171), Expect = 9e-12
Identities = 49/132 (37%), Positives = 73/132 (55%), Gaps = 4/132 (3%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKL 1035
L+R L L+ LDL L N ++ L+ Q+ L++L L++N+I D+G L
Sbjct: 1542 LMRALEGKWMLKRLDLSHLLLNS---STLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHL 1598
Query: 1036 AEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAAS 1095
+EAL + A SL L L +N I D G + LA +LP + LR +D+ N ++AG QLA S
Sbjct: 1599 SEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAES 1657
Query: 1096 LRRCPHVETLAM 1107
L C +E L +
Sbjct: 1658 LVLCRRLEELML 1669
Score = 63.9 bits (154), Expect = 8e-10
Identities = 51/181 (28%), Positives = 85/181 (46%), Gaps = 13/181 (7%)
Query: 948 AGELPAVRDLKKLEFA-LGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQ 1006
A ELP + L F+ LGP + + A HL+ +L+EN + GV +
Sbjct: 1683 AQELPQHLRVLHLPFSHLGPGGA-------LSLAQALDGSPHLEEISLAENNLAG-GVLR 1734
Query: 1007 LSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLAR 1066
P L+ ++ ++ +N T + P+L LL +L D A LA+
Sbjct: 1735 FCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLG----DEAAAELAQ 1790
Query: 1067 VLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSR 1126
VLP M L+ +D++ N+ TA GA LA L + ++ + +W IP + +HL+ Q+ R
Sbjct: 1791 VLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPR 1850
Query: 1127 I 1127
+
Sbjct: 1851 L 1851
Score = 48.1 bits (113), Expect = 5e-05
Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 1/113 (0%)
Query: 993 ALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLY 1052
+ K GD LS + P + L+ L L+ + IT G L +ALP L L +S
Sbjct: 692 SFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALP-LCPQLKEVSFR 750
Query: 1053 NNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETL 1105
+N + D ++ VLP + LR +D+ N + LA CP V L
Sbjct: 751 DNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRML 803
Score = 42.7 bits (99), Expect = 0.002
Identities = 57/225 (25%), Positives = 90/225 (40%), Gaps = 29/225 (12%)
Query: 807 LELLHCAHEAEEAGIWQHVVQELPG--RLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLR 864
L L C + +A ++QE P + G +L ++ +A LDL
Sbjct: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLS 906
Query: 865 STGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKS 924
G+ S+ G+ CV R +A L SLQ +T + A+E
Sbjct: 907 DNGL------SVAGVHCVLRAVSACWTLAELHISLQH--KTVIFMFAQEP---------- 948
Query: 925 LKDVEDLGKLVQTQRTRSSSEDTAGELP-AVRDLKKLEFALGPVSGPQAFPKLVRILTAF 983
E G + S ELP + R ++ L + +L + L
Sbjct: 949 ---EEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQE----KHLEQLCKALGGS 1001
Query: 984 SSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNIT 1028
L HL LD S N +GDEG ++L+ P L +L++LNLS+N ++
Sbjct: 1002 CHLGHLHLD-FSGNALGDEGAARLAQLLPGLGALQSLNLSENGLS 1045
Score = 41.6 bits (96), Expect = 0.004
Identities = 36/130 (27%), Positives = 57/130 (43%), Gaps = 6/130 (4%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKL 1035
L R L LQ L L+ +KI G+S L P L+ ++ N ++D +
Sbjct: 706 LSRSLPTMGRLQML---GLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNI 762
Query: 1036 AEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNK--FTAAGAQQLA 1093
E LP L L +L L +N IC LARV ++R++ + F + +
Sbjct: 763 VEVLPHL-PRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETT 821
Query: 1094 ASLRRCPHVE 1103
A L+R P ++
Sbjct: 822 AELQRAPDLQ 831
Score = 35.8 bits (81), Expect = 0.24
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 979 ILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEA 1038
+L+ L +DL A N +GD G+ L PQ+ L+LS N+I+ A L E
Sbjct: 1238 LLSKCKDLSQVDLSA---NLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLET 1294
Query: 1039 LPS 1041
LPS
Sbjct: 1295 LPS 1297
Score = 34.7 bits (78), Expect = 0.53
Identities = 17/49 (34%), Positives = 29/49 (59%)
Query: 1058 DVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLA 1106
D AE+L+R LP M L+++ + +K TA G L +L CP ++ ++
Sbjct: 700 DAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVS 748
Score = 30.4 bits (67), Expect = 9.9
Identities = 32/111 (28%), Positives = 49/111 (44%), Gaps = 6/111 (5%)
Query: 986 LQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAAS 1045
L H DL A +G + + A QL SL +NL +++ D + L L SL+
Sbjct: 1442 LAHCDLGAHHSLLVGQ--LMETCARLQQL-SLSQVNLCEDD--DASSLLLQSLLLSLS-E 1495
Query: 1046 LLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASL 1096
L L ++C+ G LA L L +D+ N+F G + L +L
Sbjct: 1496 LKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRAL 1546
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 124 bits (312), Expect = 4e-28
Identities = 187/725 (25%), Positives = 278/725 (38%), Gaps = 90/725 (12%)
Query: 416 IAVLGKAGQGKSYWAGAVSRAWACGR-LPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGP 474
+ V+G+AG GKS + WA G+ ++ FVF C L ++ LLF
Sbjct: 295 VLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCC 354
Query: 475 QPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQ 534
P V +++F +L PDRVLL DGF+E + + C +P +P S++ LL L Q
Sbjct: 355 WPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHC--SPTDPTSVQTLLFNLLQ 412
Query: 535 KKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRA 594
LL+ ++T+RP F L GFS + + Y+ + G+ DR
Sbjct: 413 GNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVA---DRL 469
Query: 595 LTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPP 654
+ LL++ L H P V + + LL ++ P T T +Y+ +L L + P
Sbjct: 470 IRLLQETSALHGLCHLPVFSWMVSKCHQELLL--QEGGSPKTTTDMYLLILQHFLLHATP 527
Query: 655 -----------------GALAELAKLA-WELGR----RHQSTLQEDQFPSADVRTWAM-- 690
L L +LA W LG LQ Q D+ +
Sbjct: 528 PDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVR 587
Query: 691 AKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKRPYDNW 750
AKG+V + + L F QCF A +LALS ++ P L RP ++
Sbjct: 588 AKGVVP----GSTAPLEFLHITFQCFFAAFYLALSADVP----PALLRHLFNCGRPGNS- 638
Query: 751 LEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLR--ARQLLE 808
+ R L P C+ A G K +A L++ +P L+ A L
Sbjct: 639 --PMARLL-------PTMCIQASEG---------KDSSVAALLQKAEPHNLQITAAFLAG 680
Query: 809 LLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGI 868
LL H W L T A + +A SL I
Sbjct: 681 LLSREH-------W-----------GLLAECQTSEKALLRRQACARWCLARSLRKHFHSI 722
Query: 869 CPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFT---IEPFKAKSL 925
P+ G + + F + + E + L K T + P + +L
Sbjct: 723 PPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAAL 782
Query: 926 KDV-EDLGKLVQTQRTRSSSEDTAGE--LPAVRDLKKLEFALGPVSGPQAFPKLVRILTA 982
V + L + V Q +S D E LP + K L +S + KL+
Sbjct: 783 AFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNIS-DRGICKLIECALH 841
Query: 983 FSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSL 1042
LQ L AL NK+ D ++ ++ L L N IT GA LAE L
Sbjct: 842 CEQLQKL---ALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRG- 897
Query: 1043 AASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHV 1102
SL L + N + D GA++LA L D SLR + + N + GAQ LA L + +
Sbjct: 898 NTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVML 957
Query: 1103 ETLAM 1107
E L +
Sbjct: 958 EELCL 962
Score = 60.8 bits (146), Expect = 7e-09
Identities = 47/126 (37%), Positives = 62/126 (49%), Gaps = 7/126 (5%)
Query: 986 LQHLDLDA---LSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSL 1042
LQHL L N +GD GV QL P L + L L NNI+D G KL E
Sbjct: 786 LQHLRRPVALQLDYNSVGDIGVEQL---LPCLGVCKALYLRDNNISDRGICKLIECALH- 841
Query: 1043 AASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHV 1102
L +L+L+NN + D A S+A++L + + + N TAAGAQ LA LR +
Sbjct: 842 CEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSL 901
Query: 1103 ETLAMW 1108
+ L W
Sbjct: 902 QFLGFW 907
Score = 55.1 bits (131), Expect = 4e-07
Identities = 46/135 (34%), Positives = 66/135 (48%), Gaps = 5/135 (3%)
Query: 997 NKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCI 1056
N++GDEG L+ +SL L+L NNI +GA LA L L L L N +
Sbjct: 909 NRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAK-NVMLEELCLEENHL 967
Query: 1057 CDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSV 1116
D G SLA L SL+++ + N T GA+ L +L R + L +W FS+
Sbjct: 968 QDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTI--LEVWLRGNTFSL 1025
Query: 1117 QE--HLQQQDSRISL 1129
+E L +D+R+ L
Sbjct: 1026 EEVDKLGCRDTRLLL 1040
Score = 45.1 bits (105), Expect = 4e-04
Identities = 42/129 (32%), Positives = 57/129 (44%), Gaps = 1/129 (0%)
Query: 994 LSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYN 1053
L N I G L+ SL+ L N + D GA LAEAL SL LSL
Sbjct: 878 LGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGD-HQSLRWLSLVG 936
Query: 1054 NCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIP 1113
N I VGA++LA +L V L + ++ N G LA L++ ++ L + I
Sbjct: 937 NNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCIT 996
Query: 1114 FSVQEHLQQ 1122
+ E L Q
Sbjct: 997 YLGAEALLQ 1005
Score = 37.7 bits (86), Expect = 0.062
Identities = 22/46 (47%), Positives = 27/46 (58%)
Query: 994 LSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEAL 1039
L EN + DEGV L+ + SL+ L LS N IT LGA L +AL
Sbjct: 962 LEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQAL 1007
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 119 bits (299), Expect = 1e-26
Identities = 183/728 (25%), Positives = 273/728 (37%), Gaps = 78/728 (10%)
Query: 416 IAVLGKAGQGKSYWAGAVSRAWACGRLPQ-YDFVFSVPCHCLN--RPGDAYGLQDLLFSL 472
I +LG AG GKS + WA GRL F F C + + D LQDLLF
Sbjct: 198 IFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFKH 257
Query: 473 GPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGL 532
P +EVF+ +L+ P L DG +EL + P EP LLA L
Sbjct: 258 YCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPAHPLVLLANL 317
Query: 533 FQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQD 592
KLL+G + LLTAR + + + L L GFS +AY R F + QD
Sbjct: 318 LSGKLLKGASKLLTARTGIEVPRQFLRKKVL--LRGFSPSHLRAYARRMFPERAL---QD 372
Query: 593 RALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA-KLPS---TLTGLYV------ 642
R L+ L P L S P C + + + E + +LP TLT +++
Sbjct: 373 RLLSQLEANPNLCSLCSVPLFCWIIFRCFQHFRAAFEGSPQLPDCTMTLTDVFLLVTEVH 432
Query: 643 -------GLLGR------AALDSPPGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWA 689
L+ R L + L L ++A + +++ ++ ++
Sbjct: 433 LNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEVQASGLQERD 492
Query: 690 MAKGLVQHPPRAA----ESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKR 745
M G ++ P + F LQ F A +L L + +EL ++
Sbjct: 493 MQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRF--------- 543
Query: 746 PYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQ 805
+ W+ P A PP L G A K K ++ G L +
Sbjct: 544 -FQEWMP--PAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAK 600
Query: 806 LLELLH----CAHEAEEAGIWQHVVQELPGRL---------SFLGTRLTPPDAHVLGKAL 852
L H A + +W H+ L G L SF + P +L
Sbjct: 601 QKLLRHLVPAAALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIY 660
Query: 853 EAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAE 912
E Q L + GIC + L +T A +D AL S H K L
Sbjct: 661 ETQSQKVG-QLAARGICANYLK-------LTYCNACSADCSAL--SFVLHHFPKRLALDL 710
Query: 913 EKFTIEPFKAKSLKDVED---LGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSG 969
+ + + + L+ + +L Q T + + EL + + L ++
Sbjct: 711 DNNNLNDYGVRELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITD 770
Query: 970 PQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITD 1029
A + +IL L HL L +NKI EG L+ KS+ + + N + D
Sbjct: 771 VGA-RYVTKILDECKGLTHL---KLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGD 826
Query: 1030 LGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGA 1089
GA AEAL + SL LSL +N I G +SLAR L SL ++ + N+ A
Sbjct: 827 EGAKAFAEALRN-HPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVA 885
Query: 1090 QQLAASLR 1097
+ LA L+
Sbjct: 886 ESLAEMLK 893
Score = 63.2 bits (152), Expect = 1e-09
Identities = 44/130 (33%), Positives = 63/130 (48%), Gaps = 7/130 (5%)
Query: 979 ILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEA 1038
+L F LDLD N + D GV +L F +L L LS N ITD G L+E
Sbjct: 698 VLHHFPKRLALDLD---NNNLNDYGVRELQPCFSRLT---VLRLSVNQITDGGVKVLSEE 751
Query: 1039 LPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRR 1098
L + L LYNN I DVGA + ++L + L + + NK T+ G + LA +++
Sbjct: 752 LTKYKI-VTYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKN 810
Query: 1099 CPHVETLAMW 1108
+ + MW
Sbjct: 811 SKSISEVGMW 820
Score = 34.7 bits (78), Expect = 0.53
Identities = 35/139 (25%), Positives = 61/139 (43%), Gaps = 8/139 (5%)
Query: 903 GETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEF 962
G+ K+ + + +KS+ +V G V + ++ +E P++ L
Sbjct: 792 GKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNH-PSLTTLSLASN 850
Query: 963 ALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNL 1022
+ G L R L +SL+ L L++N++ DE L+ ++L+ L L
Sbjct: 851 GISTEGGKS----LARALQQNTSLEIL---WLTQNELNDEVAESLAEMLKVNQTLKHLWL 903
Query: 1023 SQNNITDLGAYKLAEALPS 1041
QN IT G +LA+AL S
Sbjct: 904 IQNQITAKGTAQLADALQS 922
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 111 bits (278), Expect = 3e-24
Identities = 176/745 (23%), Positives = 292/745 (39%), Gaps = 91/745 (12%)
Query: 406 EHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAY 463
+ RP R + + G AG GKS A V WA G+L Q +D++F + C +N+
Sbjct: 203 DEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATEC 262
Query: 464 GLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGP-----A 518
+QDL+FS P+P E +++ P+R+L I+DGF+EL+ H GP
Sbjct: 263 SMQDLIFSCWPEPSAPLQE----LIRVPERLLFIIDGFDELKPS---FHDPQGPWCLCWE 315
Query: 519 PAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAY 577
P L LL L +KKLL +LL+T RP + L + E+ GFS + + Y
Sbjct: 316 EKRPTEL--LLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEY 373
Query: 578 VMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPS-T 636
+YF ++ E + +RD L + P +C VC + LE G + S T
Sbjct: 374 FYKYFHNA---EQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRT 430
Query: 637 LTGLYVGLL--------GRAALDSPPGALAELAKLAWELGRRHQSTLQEDQ------FPS 682
T +Y+ L G L PP L LA + G +Q L E+Q
Sbjct: 431 TTAVYMLYLLSLMQPKPGAPRLQPPPNQRG-LCSLAAD-GLWNQKILFEEQDLRKHGLDG 488
Query: 683 ADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLAL----SGEIKDKELPQYLA 738
DV A + E +F Q F A++ L G D+++ + L
Sbjct: 489 EDVS--AFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLT 546
Query: 739 LTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALL--GPSAAASVDRKQKVLARYLKRL 796
+R ++L RFL GL+ + L L S +D Q + + K
Sbjct: 547 EYAFSER---SFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQS---KAQ 600
Query: 797 QPGTLRARQLLELLHCAHEAEEAGIWQH--------VVQELPGRLSFLGTRLTPPDAHVL 848
G+ + LE C +E +E Q VV + ++ + +
Sbjct: 601 SDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCR-S 659
Query: 849 GKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKL- 907
+ L G +S D C +G +L+ L + L ++ +H L
Sbjct: 660 AQVLHLYGATYSADGEDRARCSAGAHTLL---------VQLPERTVLLDAYSEHLAAALC 710
Query: 908 --------------LQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPA 953
L + K + + + K +++L +L + + + S+ ED + L A
Sbjct: 711 TNPNLIELSLYRNALGSRGVKLLCQGLRHPNCK-LQNL-RLKRCRISSSACEDLSAALIA 768
Query: 954 VRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQ-HLDLDALSENKIGDEGVSQLSATFP 1012
++L +++ + V FP ++ + Q L + L + ++ ++++
Sbjct: 769 NKNLTRMDLSGNGV----GFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLG 824
Query: 1013 QLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMV 1072
L L+L+ N + DLG L + L L L L + + LA L
Sbjct: 825 TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 884
Query: 1073 SLRVMDVQYNKFTAAGAQQLAASLR 1097
SLR +D+ N+ G L LR
Sbjct: 885 SLRELDLSLNELGDLGVLLLCEGLR 909
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 106 bits (264), Expect = 1e-22
Identities = 201/746 (26%), Positives = 292/746 (39%), Gaps = 151/746 (20%)
Query: 405 KEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPC-HCLNRPGD 461
+E RRP + + G AG GK+ A + WA G+L Q DF F +PC L RPG
Sbjct: 190 EEGRRPL---TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGT 246
Query: 462 AYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAE 521
L DL+ P ++ L +P R+L ILDG +EL A G + C P E
Sbjct: 247 R-SLADLILDQCPDRGAPVPQM----LAQPQRLLFILDGADELPALGGPEAAPCTD-PFE 300
Query: 522 PCSLRGLLAGLFQKKLLRGCTLLLTARPR--GRLVQSLSKADALFELSGFSMEQAQAYVM 579
S +L GL K LL LL+T R GRL L E+ GFS + + Y
Sbjct: 301 AASGARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCA-EVRGFSDKDKKKYFY 359
Query: 580 RYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGED-AKLPSTLT 638
++F E RA +++ L + P +C VC + LELG D ++ T T
Sbjct: 360 KFFRDERRAE---RAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTT 416
Query: 639 GLYVGLLGRAALDSPP--------GALAELAKLAWE--LGRRHQ---STLQEDQFPSADV 685
+Y+ L + L S P G L L +LA E LGRR Q L++ + + V
Sbjct: 417 SVYL-LFITSVLSSAPVADGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKV 475
Query: 686 RTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLA-----LT 740
+T ++K + P E+E+ + F+ Q F L ALS ++D +P+ A L
Sbjct: 476 QTLFLSK---KELPGVLETEVTY-QFIDQSFQEFL-AALSYLLEDGGVPRTAAGGVGTLL 530
Query: 741 PRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPG- 799
+P+ + L RFL GL+ R + G + V KQ+ L R+++ G
Sbjct: 531 RGDAQPHSH-LVLTTRFLFGLLSAERMRDIERHFGCMVSERV--KQEAL-RWVQGQGQGC 586
Query: 800 -------TLRARQL------------------LELLHCAHEAEEAGIWQHVVQELPGRLS 834
T A+ L LELL+C +E +E + + P L+
Sbjct: 587 PGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFP-ELA 645
Query: 835 FLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVA 894
R D VL + CP+G +L +SC
Sbjct: 646 LQRVRFCRMDVAVLSYCVRC--------------CPAG-QALRLISC------------- 677
Query: 895 LWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQ-RTRSSSEDTAGELPA 953
L AA+EK K KS LGK +Q SSS+ T +LPA
Sbjct: 678 ------------RLVAAQEK------KKKS------LGKRLQASLGGGSSSQGTTKQLPA 713
Query: 954 VRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQ 1013
L P+ P L HL LS K+ D LS
Sbjct: 714 --------SLLHPLFQAMTDP-----------LCHLSSLTLSHCKLPDAVCRDLSEALRA 754
Query: 1014 LKSLETLNLSQNNITDLGAYKLAEAL--PSLAASLLRLSLYNNCICDVGAESLARVLPDM 1071
+L L L N +++ G L+E L P +R+ L + G + L +L
Sbjct: 755 APALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDP---QRGLQYLVGMLRQS 811
Query: 1072 VSLRVMDVQYNKFTAAGAQQLAASLR 1097
+L +D+ + A L A L+
Sbjct: 812 PALTTLDLSGCQLPAPMVTYLCAVLQ 837
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 100 bits (250), Expect = 6e-21
Identities = 129/448 (28%), Positives = 195/448 (43%), Gaps = 52/448 (11%)
Query: 408 RRPRETRVIAVL--GKAGQGKSYWAGAVSRAWA-CGRLPQYDFVFSVPCHCLNRPGDAYG 464
R PR+ V+ G AG GK+ A W C P + F + C L+R G
Sbjct: 164 RTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPC-S 222
Query: 465 LQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFL-HSTCG------P 517
+L+ P+ D++ S IL + R+L ++DG +EL+ G L CG P
Sbjct: 223 FAELISKDWPE---LQDDIPS-ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKP 278
Query: 518 APAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQA 576
P LL L ++K+L LL+T RPR R +Q L++ + GF E +A
Sbjct: 279 VPV-------LLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 577 YVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPS- 635
Y +R+F G + RA L+R L +P +C VC + +E GED +P+
Sbjct: 332 YFLRHF---GDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED-PVPTC 387
Query: 636 -TLTGLYVGLLGRAALDSPP--GALAELAKLA----W-ELGRRHQSTLQEDQFPSADVRT 687
T TGL++ L GAL L+ LA W ++ H+ L+ +D+R
Sbjct: 388 LTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRL 447
Query: 688 WAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLAL---SGEIKD------KELPQYLA 738
+ G + R ++ +F Q FL AL+ AL GE +D ++ + L+
Sbjct: 448 F--LDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505
Query: 739 LTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQP 798
R K P L V FL GL + A+ L A G S D KQ++L
Sbjct: 506 GEERLKNPD---LIQVGHFLFGLANEKRAKELEATFG--CRMSPDIKQELLQCKAHLHAN 560
Query: 799 GTLRARQLLELLHCAHEAEEAGIWQHVV 826
L L E+L C +E++E + + VV
Sbjct: 561 KPLSVTDLKEVLGCLYESQEEELAKVVV 588
Score = 40.8 bits (94), Expect = 0.007
Identities = 35/83 (42%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGAY 1033
L +L L HL L++N IGD GV L ++P K L+TL L Q +IT LG
Sbjct: 838 LAAVLVVSKKLTHL---CLAKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQQCSITKLGCR 893
Query: 1034 KLAEALPSLAASLLRLSLYNNCI 1056
L+EAL A SL L L N I
Sbjct: 894 YLSEALQE-ACSLTNLDLSINQI 915
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 100 bits (250), Expect = 6e-21
Identities = 129/448 (28%), Positives = 195/448 (43%), Gaps = 52/448 (11%)
Query: 408 RRPRETRVIAVL--GKAGQGKSYWAGAVSRAWA-CGRLPQYDFVFSVPCHCLNRPGDAYG 464
R PR+ V+ G AG GK+ A W C P + F + C L+R G
Sbjct: 164 RTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPC-S 222
Query: 465 LQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFL-HSTCG------P 517
+L+ P+ D++ S IL + R+L ++DG +EL+ G L CG P
Sbjct: 223 FAELISKDWPE---LQDDIPS-ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKP 278
Query: 518 APAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQA 576
P LL L ++K+L LL+T RPR R +Q L++ + GF E +A
Sbjct: 279 VPV-------LLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 577 YVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPS- 635
Y +R+F G + RA L+R L +P +C VC + +E GED +P+
Sbjct: 332 YFLRHF---GDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED-PVPTC 387
Query: 636 -TLTGLYVGLLGRAALDSPP--GALAELAKLA----W-ELGRRHQSTLQEDQFPSADVRT 687
T TGL++ L GAL L+ LA W ++ H+ L+ +D+R
Sbjct: 388 LTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRL 447
Query: 688 WAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLAL---SGEIKD------KELPQYLA 738
+ G + R ++ +F Q FL AL+ AL GE +D ++ + L+
Sbjct: 448 F--LDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505
Query: 739 LTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQP 798
R K P L V FL GL + A+ L A G S D KQ++L
Sbjct: 506 GEERLKNPD---LIQVGHFLFGLANEKRAKELEATFG--CRMSPDIKQELLQCKAHLHAN 560
Query: 799 GTLRARQLLELLHCAHEAEEAGIWQHVV 826
L L E+L C +E++E + + VV
Sbjct: 561 KPLSVTDLKEVLGCLYESQEEELAKVVV 588
Score = 40.8 bits (94), Expect = 0.007
Identities = 35/83 (42%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGAY 1033
L +L L HL L++N IGD GV L ++P K L+TL L Q +IT LG
Sbjct: 838 LAAVLVVSKKLTHL---CLAKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQQCSITKLGCR 893
Query: 1034 KLAEALPSLAASLLRLSLYNNCI 1056
L+EAL A SL L L N I
Sbjct: 894 YLSEALQE-ACSLTNLDLSINQI 915
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 100 bits (250), Expect = 6e-21
Identities = 129/448 (28%), Positives = 195/448 (43%), Gaps = 52/448 (11%)
Query: 408 RRPRETRVIAVL--GKAGQGKSYWAGAVSRAWA-CGRLPQYDFVFSVPCHCLNRPGDAYG 464
R PR+ V+ G AG GK+ A W C P + F + C L+R G
Sbjct: 164 RTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPC-S 222
Query: 465 LQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFL-HSTCG------P 517
+L+ P+ D++ S IL + R+L ++DG +EL+ G L CG P
Sbjct: 223 FAELISKDWPE---LQDDIPS-ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKP 278
Query: 518 APAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQA 576
P LL L ++K+L LL+T RPR R +Q L++ + GF E +A
Sbjct: 279 VPV-------LLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
Query: 577 YVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPS- 635
Y +R+F G + RA L+R L +P +C VC + +E GED +P+
Sbjct: 332 YFLRHF---GDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED-PVPTC 387
Query: 636 -TLTGLYVGLLGRAALDSPP--GALAELAKLA----W-ELGRRHQSTLQEDQFPSADVRT 687
T TGL++ L GAL L+ LA W ++ H+ L+ +D+R
Sbjct: 388 LTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRL 447
Query: 688 WAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLAL---SGEIKD------KELPQYLA 738
+ G + R ++ +F Q FL AL+ AL GE +D ++ + L+
Sbjct: 448 F--LDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505
Query: 739 LTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQP 798
R K P L V FL GL + A+ L A G S D KQ++L
Sbjct: 506 GEERLKNPD---LIQVGHFLFGLANEKRAKELEATFG--CRMSPDIKQELLQCKAHLHAN 560
Query: 799 GTLRARQLLELLHCAHEAEEAGIWQHVV 826
L L E+L C +E++E + + VV
Sbjct: 561 KPLSVTDLKEVLGCLYESQEEELAKVVV 588
Score = 40.8 bits (94), Expect = 0.007
Identities = 35/83 (42%), Positives = 43/83 (51%), Gaps = 7/83 (8%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGAY 1033
L +L L HL L++N IGD GV L ++P K L+TL L Q +IT LG
Sbjct: 810 LAAVLVVSKKLTHL---CLAKNPIGDTGVKFLCEGLSYPDCK-LQTLVLQQCSITKLGCR 865
Query: 1034 KLAEALPSLAASLLRLSLYNNCI 1056
L+EAL A SL L L N I
Sbjct: 866 YLSEALQE-ACSLTNLDLSINQI 887
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 98.6 bits (244), Expect = 3e-20
Identities = 201/784 (25%), Positives = 303/784 (38%), Gaps = 130/784 (16%)
Query: 406 EHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAY 463
EH P T V G AG GK+ A + WA G L Q +D++F + C ++
Sbjct: 214 EHSEPVHTVVFQ--GAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQR- 270
Query: 464 GLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAE-P 522
L DL+ S P P + I+++P R+L ++DGF+EL+ G GP +
Sbjct: 271 SLGDLIMSCCPDP----NPPIHKIVRKPSRILFLMDGFDELQ---GAFDEHIGPLCTDWQ 323
Query: 523 CSLRG--LLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAYVM 579
+ RG LL+ L +KKLL +LL+T RP +Q L E+ GFS + + Y
Sbjct: 324 KAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFF 383
Query: 580 RYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGED-AKLPSTLT 638
+YF A +L+++ +L + P +C VC + +E G+ A+ T T
Sbjct: 384 KYFSDEAQAR---AAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTT 440
Query: 639 GLYVGLLGRAALDSPPGALAE--LAKLAWELGRRHQSTL--QEDQFPSADVRTWAMAKGL 694
+YV L ++L P G E L W L + Q+ F +D+R + K
Sbjct: 441 AVYVFFL--SSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKAD 498
Query: 695 VQHPPRA--------AESELAFPSFLLQCFLGALWLALSGEIKDK--------ELP--QY 736
V R E +F Q F A++ L E + + +LP
Sbjct: 499 VSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDV 558
Query: 737 LALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRL 796
L + +L V RFL GL+ Q L L S Q++ LK +
Sbjct: 559 TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKL------SCKISQQIRLELLKWI 612
Query: 797 QPGTLRARQL------LELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGK 850
+ +A++L LEL +C +E +E Q + P L TR+ D V
Sbjct: 613 EV-KAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRM---DHMVSSF 668
Query: 851 ALEAAGQDFSLDL-----------------------------RSTGICPSGLGSLVGLSC 881
+E + SL L S C GLG GLS
Sbjct: 669 CIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGR-CGLSH 727
Query: 882 VTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGK--LVQTQR 939
F D + S Q+ E L A F I + +L K LV
Sbjct: 728 ECCF-----DISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
Query: 940 TRSSSEDTAGELPAVRDLKKL---EFALG---------PVSGPQA-FPKLVRILTAFSSL 986
T + +D A L L +L E ALG PQ KL + + +S+
Sbjct: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
Query: 987 ------------QHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGA 1032
Q+L L N +GD+G+ L P K L+ L L N+T
Sbjct: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK-LQVLELDNCNLTSHCC 901
Query: 1033 YKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPD----MVSLRVMDVQYNKFTAAG 1088
+ L+ L S + SL +LSL NN + D+G VL + +L + ++ +N T +
Sbjct: 902 WDLSTLLTS-SQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 960
Query: 1089 AQQL 1092
+ L
Sbjct: 961 LETL 964
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 95.5 bits (236), Expect = 3e-19
Identities = 177/722 (24%), Positives = 274/722 (37%), Gaps = 103/722 (14%)
Query: 406 EHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAY 463
EH P T V G AG GK+ A + WA G L Q +D++F + C ++
Sbjct: 214 EHSEPVHTVVFQ--GAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQR- 270
Query: 464 GLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAE-P 522
L DL+ S P P + I+++P R+L ++DGF+EL+ G GP +
Sbjct: 271 SLGDLIMSCCPDP----NPPIHKIVRKPSRILFLMDGFDELQ---GAFDEHIGPLCTDWQ 323
Query: 523 CSLRG--LLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAYVM 579
+ RG LL+ L +KKLL +LL+T RP +Q L E+ GFS + + Y
Sbjct: 324 KAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFF 383
Query: 580 RYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGED-AKLPSTLT 638
+YF A +L+++ +L + P +C VC + +E G+ A+ T T
Sbjct: 384 KYFSDEAQAR---AAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTT 440
Query: 639 GLYVGLLGRAALDSPPGALAE--LAKLAWELGRRHQSTL--QEDQFPSADVRTWAMAKGL 694
+YV L ++L P G E L W L + Q+ F +D+R + K
Sbjct: 441 AVYVFFL--SSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKAD 498
Query: 695 VQHPPRA--------AESELAFPSFLLQCFLGALWLALSGEIKDK--------ELP--QY 736
V R E +F Q F A++ L E + + +LP
Sbjct: 499 VSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDV 558
Query: 737 LALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRL 796
L + +L V RFL GL+ Q L L S Q++ LK +
Sbjct: 559 TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKL------SCKISQQIRLELLKWI 612
Query: 797 QPGTLRARQL------LELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGK 850
+ +A++L LEL +C +E +E Q + P L TR+ D V
Sbjct: 613 EV-KAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRM---DHMVSSF 668
Query: 851 ALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQA 910
+E + SL L P E ++ E + L
Sbjct: 669 CIENCHRVESLSLGFLHNMPK-------------------------EEEEEEKEGRHLDM 703
Query: 911 AEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGP 970
+ A S LV + T S L + L +L+ + + P
Sbjct: 704 VQCVLPSSSHAACS-------HGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDP 756
Query: 971 QAFPKLVRILTAFSSLQHLDLDA----LSENKIGDEGVSQLSATFPQLKSLETLNLSQNN 1026
+R+L +LQH + L + E +S + L L+LS N
Sbjct: 757 G-----MRVLC--ETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNA 809
Query: 1027 ITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTA 1086
+ D G L L L +L +L L + C+ + LA VL SL + V N
Sbjct: 810 LGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGD 869
Query: 1087 AG 1088
+G
Sbjct: 870 SG 871
Score = 36.6 bits (83), Expect = 0.14
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 11/123 (8%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGAY 1033
L +L+ +L HL L N +GD+G+ L P K L+ L L N+T +
Sbjct: 904 LSSVLSTNQNLTHLYLRG---NTLGDKGIKLLCEGLLHPDCK-LQVLELDNCNLTSHCCW 959
Query: 1034 KLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPD----MVSLRVMDVQYNKFTAAGA 1089
L+ L S + SL +LSL NN + D+G VL + +L + ++ +N T +
Sbjct: 960 DLSTLLTS-SQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018
Query: 1090 QQL 1092
+ L
Sbjct: 1019 ETL 1021
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 95.5 bits (236), Expect = 3e-19
Identities = 177/722 (24%), Positives = 274/722 (37%), Gaps = 103/722 (14%)
Query: 406 EHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAY 463
EH P T V G AG GK+ A + WA G L Q +D++F + C ++
Sbjct: 214 EHSEPVHTVVFQ--GAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQR- 270
Query: 464 GLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAE-P 522
L DL+ S P P + I+++P R+L ++DGF+EL+ G GP +
Sbjct: 271 SLGDLIMSCCPDP----NPPIHKIVRKPSRILFLMDGFDELQ---GAFDEHIGPLCTDWQ 323
Query: 523 CSLRG--LLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAYVM 579
+ RG LL+ L +KKLL +LL+T RP +Q L E+ GFS + + Y
Sbjct: 324 KAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFF 383
Query: 580 RYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGED-AKLPSTLT 638
+YF A +L+++ +L + P +C VC + +E G+ A+ T T
Sbjct: 384 KYFSDEAQAR---AAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTT 440
Query: 639 GLYVGLLGRAALDSPPGALAE--LAKLAWELGRRHQSTL--QEDQFPSADVRTWAMAKGL 694
+YV L ++L P G E L W L + Q+ F +D+R + K
Sbjct: 441 AVYVFFL--SSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKAD 498
Query: 695 VQHPPRA--------AESELAFPSFLLQCFLGALWLALSGEIKDK--------ELP--QY 736
V R E +F Q F A++ L E + + +LP
Sbjct: 499 VSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDV 558
Query: 737 LALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRL 796
L + +L V RFL GL+ Q L L S Q++ LK +
Sbjct: 559 TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKL------SCKISQQIRLELLKWI 612
Query: 797 QPGTLRARQL------LELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGK 850
+ +A++L LEL +C +E +E Q + P L TR+ D V
Sbjct: 613 EV-KAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRM---DHMVSSF 668
Query: 851 ALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQA 910
+E + SL L P E ++ E + L
Sbjct: 669 CIENCHRVESLSLGFLHNMPK-------------------------EEEEEEKEGRHLDM 703
Query: 911 AEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGP 970
+ A S LV + T S L + L +L+ + + P
Sbjct: 704 VQCVLPSSSHAACS-------HGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDP 756
Query: 971 QAFPKLVRILTAFSSLQHLDLDA----LSENKIGDEGVSQLSATFPQLKSLETLNLSQNN 1026
+R+L +LQH + L + E +S + L L+LS N
Sbjct: 757 G-----MRVLC--ETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNA 809
Query: 1027 ITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTA 1086
+ D G L L L +L +L L + C+ + LA VL SL + V N
Sbjct: 810 LGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGD 869
Query: 1087 AG 1088
+G
Sbjct: 870 SG 871
Score = 36.6 bits (83), Expect = 0.14
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 11/123 (8%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGAY 1033
L +L+ +L HL L N +GD+G+ L P K L+ L L N+T +
Sbjct: 904 LSSVLSTNQNLTHLYLRG---NTLGDKGIKLLCEGLLHPDCK-LQVLELDNCNLTSHCCW 959
Query: 1034 KLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPD----MVSLRVMDVQYNKFTAAGA 1089
L+ L S + SL +LSL NN + D+G VL + +L + ++ +N T +
Sbjct: 960 DLSTLLTS-SQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018
Query: 1090 QQL 1092
+ L
Sbjct: 1019 ETL 1021
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 94.0 bits (232), Expect = 7e-19
Identities = 177/730 (24%), Positives = 278/730 (38%), Gaps = 103/730 (14%)
Query: 406 EHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAY 463
EH P T V G AG GK+ A + WA G L Q +D++F + C ++
Sbjct: 214 EHSEPVHTVVFQ--GAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQR- 270
Query: 464 GLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAE-P 522
L DL+ S P P + I+++P R+L ++DGF+EL+ G GP +
Sbjct: 271 SLGDLIMSCCPDP----NPPIHKIVRKPSRILFLMDGFDELQ---GAFDEHIGPLCTDWQ 323
Query: 523 CSLRG--LLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAYVM 579
+ RG LL+ L +KKLL +LL+T RP +Q L E+ GFS + + Y
Sbjct: 324 KAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFF 383
Query: 580 RYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGED-AKLPSTLT 638
+YF A +L+++ +L + P +C VC + +E G+ A+ T T
Sbjct: 384 KYFSDEAQAR---AAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTT 440
Query: 639 GLYVGLLGRAALDSPPGALAE--LAKLAWELGRRHQSTL--QEDQFPSADVRTWAMAKGL 694
+YV L ++L P G E L W L + Q+ F +D+R + K
Sbjct: 441 AVYVFFL--SSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKAD 498
Query: 695 VQHPPRA--------AESELAFPSFLLQCFLGALWLALSGEIKDK--------ELP--QY 736
V R E +F Q F A++ L E + + +LP
Sbjct: 499 VSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDV 558
Query: 737 LALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRL 796
L + +L V RFL GL+ Q L L S Q++ LK +
Sbjct: 559 TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKL------SCKISQQIRLELLKWI 612
Query: 797 QPGTLRARQL------LELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGK 850
+ +A++L LEL +C +E +E Q + P L TR+ D V
Sbjct: 613 EV-KAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRM---DHMVSSF 668
Query: 851 ALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQA 910
+E + SL L P E ++ E + L
Sbjct: 669 CIENCHRVESLSLGFLHNMPK-------------------------EEEEEEKEGRHLDM 703
Query: 911 AEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGP 970
+ A S LV + T S L + L +L+ + + P
Sbjct: 704 VQCVLPSSSHAACS-------HGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDP 756
Query: 971 QAFPKLVRILTAFSSLQHLDLDA----LSENKIGDEGVSQLSATFPQLKSLETLNLSQNN 1026
+R+L +LQH + L + E +S + L L+LS N
Sbjct: 757 G-----MRVLC--ETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNA 809
Query: 1027 ITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTA 1086
+ D G L L L +L +L L N+ + V +L+ VL +L + ++ N
Sbjct: 810 LGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGD 869
Query: 1087 AGAQQLAASL 1096
G + L L
Sbjct: 870 KGIKLLCEGL 879
Score = 36.6 bits (83), Expect = 0.14
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 11/123 (8%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGAY 1033
L +L+ +L HL L N +GD+G+ L P K L+ L L N+T +
Sbjct: 847 LSSVLSTNQNLTHLYLRG---NTLGDKGIKLLCEGLLHPDCK-LQVLELDNCNLTSHCCW 902
Query: 1034 KLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPD----MVSLRVMDVQYNKFTAAGA 1089
L+ L S + SL +LSL NN + D+G VL + +L + ++ +N T +
Sbjct: 903 DLSTLLTS-SQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 961
Query: 1090 QQL 1092
+ L
Sbjct: 962 ETL 964
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 94.0 bits (232), Expect = 7e-19
Identities = 119/440 (27%), Positives = 191/440 (43%), Gaps = 51/440 (11%)
Query: 416 IAVLGKAGQGKSYWAGAVSRAWACGRL-PQYDFVFSVPCHCLNRPGDAYGLQDLLFSLGP 474
+ + G AG GK+ A + WA L ++ + F + C L+R G +L+F P
Sbjct: 209 VVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLGPC-SFAELVFRDWP 267
Query: 475 QPLVAADEVFSHILKRPDRVLLILDGFEELEAQDG-FLHSTCG------PAPAEPCSLRG 527
+ + HIL + ++L ++DGF+EL A G + CG P P
Sbjct: 268 E----LQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPV------- 316
Query: 528 LLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAYVMRYFESSG 586
LL L + +L LL+T RPR R ++ L++ + GF E +AY +R+F G
Sbjct: 317 LLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHF---G 373
Query: 587 MTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPS--TLTGLYVGL 644
+ RA L+R L +P +C VC + +E GED +P+ T TGL++
Sbjct: 374 DEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED-PVPTCLTRTGLFLRF 432
Query: 645 LGRAALDSPP--GALAELAKLA----W-ELGRRHQSTLQEDQFPSADVRTWAMAKGLVQH 697
L GAL L+ LA W + H+ L+ +D+R + G +
Sbjct: 433 LCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLF--LDGDILR 490
Query: 698 PPRAAESELAFPSFLLQCFLGALWLALSGEIKDK---------ELPQYLALTPRKKRPYD 748
R ++ +F Q FL AL+ L E ++ ++ + L+ R + P D
Sbjct: 491 QDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNP-D 549
Query: 749 NWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLE 808
G F GL + A+ L A G S D KQ++L R + G L E
Sbjct: 550 LIQAGYYSF--GLANEKRAKELEATFG--CRMSPDIKQELL-RCDISCKGGHSTVTDLQE 604
Query: 809 LLHCAHEAEEAGIWQHVVQE 828
LL C +E++E + + V+ +
Sbjct: 605 LLGCLYESQEEELVKEVMAQ 624
Score = 37.7 bits (86), Expect = 0.062
Identities = 41/139 (29%), Positives = 60/139 (43%), Gaps = 7/139 (5%)
Query: 973 FPKLVRILT-AFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLG 1031
FP L +L +L++L L + S + + LS +SL +NLS N + D G
Sbjct: 771 FPALCEVLRHPECNLRYLGLVSCSATT---QQWADLSLALEVNQSLTCVNLSDNELLDEG 827
Query: 1032 AYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQ 1091
A L L L RLSL N + + + LA VL L + + N G +
Sbjct: 828 AKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKF 887
Query: 1092 LAASLR--RCPHVETLAMW 1108
L LR C ++TL +W
Sbjct: 888 LCEGLRYPEC-KLQTLVLW 905
Score = 33.9 bits (76), Expect = 0.90
Identities = 41/157 (26%), Positives = 60/157 (38%), Gaps = 3/157 (1%)
Query: 940 TRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKI 999
T ++ +D A L R+L L A P+ + LQ L L I
Sbjct: 853 TEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTL---VLWNCDI 909
Query: 1000 GDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDV 1059
+G L+ + SL L+L N+I G L EAL +L L L+ I
Sbjct: 910 TSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPF 969
Query: 1060 GAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASL 1096
E L L SL +D+ N ++G + L +L
Sbjct: 970 SCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETL 1006
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 92.4 bits (228), Expect = 2e-18
Identities = 126/470 (26%), Positives = 195/470 (41%), Gaps = 57/470 (12%)
Query: 406 EHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAY 463
EH P T V G AG GK+ A + WA G L Q +D++F + C ++
Sbjct: 214 EHSEPVHTVVFQ--GAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQR- 270
Query: 464 GLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAE-P 522
L DL+ S P P + I+++P R+L ++DGF+EL+ G GP +
Sbjct: 271 SLGDLIMSCCPDP----NPPIHKIVRKPSRILFLMDGFDELQ---GAFDEHIGPLCTDWQ 323
Query: 523 CSLRG--LLAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAYVM 579
+ RG LL+ L +KKLL +LL+T RP +Q L E+ GFS + + Y
Sbjct: 324 KAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFF 383
Query: 580 RYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGED-AKLPSTLT 638
+YF A +L+++ +L + P +C VC + +E G+ A+ T T
Sbjct: 384 KYFSDEAQAR---AAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTT 440
Query: 639 GLYVGLLGRAALDSPPGALAE--LAKLAWELGRRHQSTL--QEDQFPSADVRTWAMAKGL 694
+YV L ++L P G E L W L + Q+ F +D+R + K
Sbjct: 441 AVYVFFL--SSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKAD 498
Query: 695 VQHPPRA--------AESELAFPSFLLQCFLGALWLALSGEIKDK--------ELP--QY 736
V R E +F Q F A++ L E + + +LP
Sbjct: 499 VSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDV 558
Query: 737 LALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRL 796
L + +L V RFL GL+ Q L L S Q++ LK +
Sbjct: 559 TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKL------SCKISQQIRLELLKWI 612
Query: 797 QPGTLRARQL------LELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRL 840
+ +A++L LEL +C +E +E Q + P L TR+
Sbjct: 613 EV-KAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRM 661
Score = 36.6 bits (83), Expect = 0.14
Identities = 36/123 (29%), Positives = 58/123 (47%), Gaps = 11/123 (8%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGAY 1033
L +L+ +L HL L N +GD+G+ L P K L+ L L N+T +
Sbjct: 790 LSSVLSTNQNLTHLYLRG---NTLGDKGIKLLCEGLLHPDCK-LQVLELDNCNLTSHCCW 845
Query: 1034 KLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPD----MVSLRVMDVQYNKFTAAGA 1089
L+ L S + SL +LSL NN + D+G VL + +L + ++ +N T +
Sbjct: 846 DLSTLLTS-SQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 904
Query: 1090 QQL 1092
+ L
Sbjct: 905 ETL 907
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 78.6 bits (192), Expect = 3e-14
Identities = 89/316 (28%), Positives = 143/316 (45%), Gaps = 27/316 (8%)
Query: 352 EPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPR 411
+ AG +G +V LV + SS+S E LA P + E++L + E L + E +P
Sbjct: 113 QEAGVNGRYNQVLLVA----KPSSESPE-SLACP-FPEQEL-ESVTVEALFDSGE--KPS 163
Query: 412 ETRVIAVL-GKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPCHCLNRPGDAYGLQDL 468
+ VL G AG GK+ A + WA G L ++D+VF V C + ++ Q L
Sbjct: 164 LAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLL 223
Query: 469 LFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGL 528
+ G + IL++P+R+L ILDGF+EL+ G +P E L
Sbjct: 224 FWCCGDNQAPVTE-----ILRQPERLLFILDGFDELQRPFEEKLKKRGLSPKE-----SL 273
Query: 529 LAGLFQKKLLRGCTLLLTARPRG-RLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGM 587
L L ++ L C+LL+T RP R ++ L K + GFS E+ Y YF
Sbjct: 274 LHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDE-- 331
Query: 588 TEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA-KLPSTLTGLYVGLLG 646
+ DRA +++ +L P +C VC + +E G+ + P T +++ +
Sbjct: 332 -KQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVS 390
Query: 647 RAALDSPPGALAELAK 662
G +EL++
Sbjct: 391 TFLPPDDDGGCSELSR 406
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/517 (26%), Positives = 194/517 (37%), Gaps = 97/517 (18%)
Query: 211 PFSSSS--LSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPP 268
P+S S L + P +P I LP G Q SE Q+P
Sbjct: 97 PYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRV--------------LRQLPD 142
Query: 269 PSG---------FTVHGLPTSPDR--PGSTSPFAPSATDL----PSMPEPALTSRANMTE 313
SG LP+SPD P SP AP++T + S P+P+L R E
Sbjct: 143 TSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPR----E 198
Query: 314 HKTSPTQCPA--------------AGEVSNK-LPKWPEPV---EQFYRSLQDTYGA-EPA 354
+ TQ P E S K P W V Q + SLQ + EP+
Sbjct: 199 QEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPS 258
Query: 355 GPDGI--------------LVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEV 400
+ + ++ L+Q RS ++R + PD+ E +G L E+
Sbjct: 259 VRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKR--SWPDYVEEN--RGHLIEI 314
Query: 401 LLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPCHCLNR 458
+E R++ + G AG GKS A V AW G+L ++ VF C L +
Sbjct: 315 RDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ 374
Query: 459 PGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEE-----LEAQDGFLHS 513
L +L+ G A IL RP+R+L ILDG +E E
Sbjct: 375 -SKVVSLAELIGKDG----TATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLH 429
Query: 514 TCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG--RLVQSLSKADALFELSGFSM 571
P PA+ LL L K +L + L+TAR L+ SL +A E+ GFS
Sbjct: 430 WSQPQPAD-----ALLGSLLGKTILPEASFLITARTTALQNLIPSLEQA-RWVEVLGFSE 483
Query: 572 EQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA 631
+ Y RYF RA L++ L + P + C ++ E
Sbjct: 484 SSRKEYFYRYFTDE---RQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 632 KLPS-TLTGLYVGLLGRAALDSPPG-ALAELAKLAWE 666
L S T T L + L +A P G L +L LA E
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAE 577
Score = 38.5 bits (88), Expect = 0.036
Identities = 32/119 (26%), Positives = 51/119 (42%), Gaps = 3/119 (2%)
Query: 940 TRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKI 999
T +D A L A + L +L+ + ++ A R+ LQ L L + +
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCG---L 906
Query: 1000 GDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICD 1058
+ L++ SL+ L+L QNN+ D+G L E L A L+RL L + D
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSD 965
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/517 (26%), Positives = 194/517 (37%), Gaps = 97/517 (18%)
Query: 211 PFSSSS--LSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPP 268
P+S S L + P +P I LP G Q SE Q+P
Sbjct: 97 PYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRV--------------LRQLPD 142
Query: 269 PSG---------FTVHGLPTSPDR--PGSTSPFAPSATDL----PSMPEPALTSRANMTE 313
SG LP+SPD P SP AP++T + S P+P+L R E
Sbjct: 143 TSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPR----E 198
Query: 314 HKTSPTQCPA--------------AGEVSNK-LPKWPEPV---EQFYRSLQDTYGA-EPA 354
+ TQ P E S K P W V Q + SLQ + EP+
Sbjct: 199 QEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPS 258
Query: 355 GPDGI--------------LVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEV 400
+ + ++ L+Q RS ++R + PD+ E +G L E+
Sbjct: 259 VRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKR--SWPDYVEEN--RGHLIEI 314
Query: 401 LLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPCHCLNR 458
+E R++ + G AG GKS A V AW G+L ++ VF C L +
Sbjct: 315 RDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ 374
Query: 459 PGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEE-----LEAQDGFLHS 513
L +L+ G A IL RP+R+L ILDG +E E
Sbjct: 375 -SKVVSLAELIGKDG----TATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLH 429
Query: 514 TCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG--RLVQSLSKADALFELSGFSM 571
P PA+ LL L K +L + L+TAR L+ SL +A E+ GFS
Sbjct: 430 WSQPQPAD-----ALLGSLLGKTILPEASFLITARTTALQNLIPSLEQA-RWVEVLGFSE 483
Query: 572 EQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA 631
+ Y RYF RA L++ L + P + C ++ E
Sbjct: 484 SSRKEYFYRYFTDE---RQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 632 KLPS-TLTGLYVGLLGRAALDSPPG-ALAELAKLAWE 666
L S T T L + L +A P G L +L LA E
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAE 577
Score = 35.8 bits (81), Expect = 0.24
Identities = 30/110 (27%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 940 TRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKI 999
T +D A L A + L +L+ + ++ A R+ LQ L L + +
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCG---L 906
Query: 1000 GDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRL 1049
+ L++ SL+ L+L QNN+ D+G L E L A L+RL
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/517 (26%), Positives = 194/517 (37%), Gaps = 97/517 (18%)
Query: 211 PFSSSS--LSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPP 268
P+S S L + P +P I LP G Q SE Q+P
Sbjct: 97 PYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRV--------------LRQLPD 142
Query: 269 PSG---------FTVHGLPTSPDR--PGSTSPFAPSATDL----PSMPEPALTSRANMTE 313
SG LP+SPD P SP AP++T + S P+P+L R E
Sbjct: 143 TSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPR----E 198
Query: 314 HKTSPTQCPA--------------AGEVSNK-LPKWPEPV---EQFYRSLQDTYGA-EPA 354
+ TQ P E S K P W V Q + SLQ + EP+
Sbjct: 199 QEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPS 258
Query: 355 GPDGI--------------LVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEV 400
+ + ++ L+Q RS ++R + PD+ E +G L E+
Sbjct: 259 VRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKR--SWPDYVEEN--RGHLIEI 314
Query: 401 LLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPCHCLNR 458
+E R++ + G AG GKS A V AW G+L ++ VF C L +
Sbjct: 315 RDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ 374
Query: 459 PGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEE-----LEAQDGFLHS 513
L +L+ G A IL RP+R+L ILDG +E E
Sbjct: 375 -SKVVSLAELIGKDG----TATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLH 429
Query: 514 TCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG--RLVQSLSKADALFELSGFSM 571
P PA+ LL L K +L + L+TAR L+ SL +A E+ GFS
Sbjct: 430 WSQPQPAD-----ALLGSLLGKTILPEASFLITARTTALQNLIPSLEQA-RWVEVLGFSE 483
Query: 572 EQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA 631
+ Y RYF RA L++ L + P + C ++ E
Sbjct: 484 SSRKEYFYRYFTDE---RQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 632 KLPS-TLTGLYVGLLGRAALDSPPG-ALAELAKLAWE 666
L S T T L + L +A P G L +L LA E
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAE 577
Score = 38.5 bits (88), Expect = 0.036
Identities = 32/119 (26%), Positives = 51/119 (42%), Gaps = 3/119 (2%)
Query: 940 TRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKI 999
T +D A L A + L +L+ + ++ A R+ LQ L L + +
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCG---L 906
Query: 1000 GDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICD 1058
+ L++ SL+ L+L QNN+ D+G L E L A L+RL L + D
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSD 965
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/517 (26%), Positives = 194/517 (37%), Gaps = 97/517 (18%)
Query: 211 PFSSSS--LSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPP 268
P+S S L + P +P I LP G Q SE Q+P
Sbjct: 97 PYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRV--------------LRQLPD 142
Query: 269 PSG---------FTVHGLPTSPDR--PGSTSPFAPSATDL----PSMPEPALTSRANMTE 313
SG LP+SPD P SP AP++T + S P+P+L R E
Sbjct: 143 TSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPR----E 198
Query: 314 HKTSPTQCPA--------------AGEVSNK-LPKWPEPV---EQFYRSLQDTYGA-EPA 354
+ TQ P E S K P W V Q + SLQ + EP+
Sbjct: 199 QEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPS 258
Query: 355 GPDGI--------------LVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEV 400
+ + ++ L+Q RS ++R + PD+ E +G L E+
Sbjct: 259 VRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKR--SWPDYVEEN--RGHLIEI 314
Query: 401 LLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPCHCLNR 458
+E R++ + G AG GKS A V AW G+L ++ VF C L +
Sbjct: 315 RDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ 374
Query: 459 PGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEE-----LEAQDGFLHS 513
L +L+ G A IL RP+R+L ILDG +E E
Sbjct: 375 -SKVVSLAELIGKDG----TATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLH 429
Query: 514 TCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG--RLVQSLSKADALFELSGFSM 571
P PA+ LL L K +L + L+TAR L+ SL +A E+ GFS
Sbjct: 430 WSQPQPAD-----ALLGSLLGKTILPEASFLITARTTALQNLIPSLEQA-RWVEVLGFSE 483
Query: 572 EQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA 631
+ Y RYF RA L++ L + P + C ++ E
Sbjct: 484 SSRKEYFYRYFTDE---RQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 632 KLPS-TLTGLYVGLLGRAALDSPPG-ALAELAKLAWE 666
L S T T L + L +A P G L +L LA E
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAE 577
Score = 35.8 bits (81), Expect = 0.24
Identities = 30/110 (27%), Positives = 48/110 (43%), Gaps = 3/110 (2%)
Query: 940 TRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKI 999
T +D A L A + L +L+ + ++ A R+ LQ L L + +
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCG---L 906
Query: 1000 GDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRL 1049
+ L++ SL+ L+L QNN+ D+G L E L A L+RL
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 76.3 bits (186), Expect = 2e-13
Identities = 139/517 (26%), Positives = 194/517 (37%), Gaps = 97/517 (18%)
Query: 211 PFSSSS--LSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPP 268
P+S S L + P +P I LP G Q SE Q+P
Sbjct: 97 PYSPSEPHLGSPSQPTSTAVLMPWIHELPAGCTQGSERRV--------------LRQLPD 142
Query: 269 PSG---------FTVHGLPTSPDR--PGSTSPFAPSATDL----PSMPEPALTSRANMTE 313
SG LP+SPD P SP AP++T + S P+P+L R E
Sbjct: 143 TSGRRWREISASLLYQALPSSPDHESPSQESPNAPTSTAVLGSWGSPPQPSLAPR----E 198
Query: 314 HKTSPTQCPA--------------AGEVSNK-LPKWPEPV---EQFYRSLQDTYGA-EPA 354
+ TQ P E S K P W V Q + SLQ + EP+
Sbjct: 199 QEAPGTQWPLDETSGIYYTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHPWEPS 258
Query: 355 GPDGI--------------LVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEV 400
+ + ++ L+Q RS ++R + PD+ E +G L E+
Sbjct: 259 VRESLCSTWPWKNEDFNQKFTQLLLLQRPHPRSQDPLVKR--SWPDYVEEN--RGHLIEI 314
Query: 401 LLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPCHCLNR 458
+E R++ + G AG GKS A V AW G+L ++ VF C L +
Sbjct: 315 RDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQ 374
Query: 459 PGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEE-----LEAQDGFLHS 513
L +L+ G A IL RP+R+L ILDG +E E
Sbjct: 375 -SKVVSLAELIGKDG----TATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLH 429
Query: 514 TCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRG--RLVQSLSKADALFELSGFSM 571
P PA+ LL L K +L + L+TAR L+ SL +A E+ GFS
Sbjct: 430 WSQPQPAD-----ALLGSLLGKTILPEASFLITARTTALQNLIPSLEQA-RWVEVLGFSE 483
Query: 572 EQAQAYVMRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDA 631
+ Y RYF RA L++ L + P + C ++ E
Sbjct: 484 SSRKEYFYRYFTDE---RQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKL 540
Query: 632 KLPS-TLTGLYVGLLGRAALDSPPG-ALAELAKLAWE 666
L S T T L + L +A P G L +L LA E
Sbjct: 541 TLTSKTTTTLCLHYLAQALQAQPLGPQLRDLCSLAAE 577
Score = 38.5 bits (88), Expect = 0.036
Identities = 32/119 (26%), Positives = 51/119 (42%), Gaps = 3/119 (2%)
Query: 940 TRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKI 999
T +D A L A + L +L+ + ++ A R+ LQ L L + +
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCG---L 906
Query: 1000 GDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICD 1058
+ L++ SL+ L+L QNN+ D+G L E L A L+RL L + D
Sbjct: 907 TSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSD 965
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 76.3 bits (186), Expect = 2e-13
Identities = 182/761 (23%), Positives = 290/761 (38%), Gaps = 143/761 (18%)
Query: 414 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLF-SL 472
RV +G AG GK+ R WA G++ + DF +P L F L
Sbjct: 139 RVSITIGVAGMGKTTLVRHFVRLWAHGQVGK-DFSLVLP---------------LTFRDL 182
Query: 473 GPQPLVAADE----VFSHI------LKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEP 522
+ AD VF H+ + P R LLILDG +E F ++ P +
Sbjct: 183 NTHEKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKE 242
Query: 523 CSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYF 582
+ L+ + + L ++ +T+RP D + E+ GF+ E+ + + + F
Sbjct: 243 IPVDHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDRMTEIRGFNEEEIKVCLEQMF 302
Query: 583 ESSGMTEHQDRALT------LLRDRPLLLSHSHSPTLCRAVCQLSEALLELG---EDAKL 633
+D+AL + DR L L + P CR L +DA+L
Sbjct: 303 P-------EDQALLGWMLSQVQADRALYLMCT-VPAFCRLTGMALGHLWRSRTGPQDAEL 354
Query: 634 --PSTLTGLY-----VGLLGRAALDSPPGALAELA-----KLAWELGRR--HQSTLQEDQ 679
P TL LY + L G E K+ LGR H ++
Sbjct: 355 WPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYV 414
Query: 680 FPSADVRTWAMAKGLVQHPPRAA----ESELA------FPSFLLQCFLGALWL--ALSGE 727
F D++ + + L+Q P + E LA F LQ F+ A + A
Sbjct: 415 FYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRA 474
Query: 728 IKDKE------------LPQYLALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLG 775
I D L + + R + D L+ RFL+GL+ + + ALL
Sbjct: 475 IFDLFTESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLL----SPRVNALLA 530
Query: 776 PSAAASVDRK--QKVLARYLKR-LQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELP-G 831
S A + + + +A L+ L+P + + +LHC HE + + + V + + G
Sbjct: 531 GSLLAQGEHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESG 590
Query: 832 RLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSD 891
L+ RLT P AH A D +C +LS
Sbjct: 591 ALA----RLTGP-AHRAALAYLLQVSD---------------------ACAQEANLSLSL 624
Query: 892 TVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGEL 951
+ + +SL +LL + + F+ + E LG ++ + R
Sbjct: 625 SQGVLQSLLP----QLLYCRKLRLDTNQFQDPVM---ELLGSVLSGKDCR---------- 667
Query: 952 PAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATF 1011
++K+ A +S A L R L SL LDL N IG +G L+
Sbjct: 668 -----IQKISLAENQISNKGA-KALARSLLVNRSLTSLDLRG---NSIGPQGAKALADAL 718
Query: 1012 PQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDM 1071
++L +L+L N + D GA +AEAL S +L L L N I +GA+ +A L
Sbjct: 719 KINRTLTSLSLQGNTVRDDGARSMAEALAS-NRTLSMLHLQKNSIGPMGAQRMADALKQN 777
Query: 1072 VSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTI 1112
SL+ + N GA+ LA +L+ +E+L + + +I
Sbjct: 778 RSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI 818
Score = 65.9 bits (159), Expect = 2e-10
Identities = 78/313 (24%), Positives = 132/313 (42%), Gaps = 32/313 (10%)
Query: 796 LQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPG-----------RLSFLGTRLTPPD 844
L G L++ L +LL+C + +Q V EL G ++S +++
Sbjct: 624 LSQGVLQSL-LPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKG 682
Query: 845 AHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGE 904
A L ++L SLDLR I P G +L + R +LS +++ G
Sbjct: 683 AKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLS---LQGNTVRDDGA 739
Query: 905 TKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFAL 964
+ +A T+ + +G + ++ A L R LK+L F+
Sbjct: 740 RSMAEALASNRTLSMLHLQK----NSIGPM--------GAQRMADALKQNRSLKELMFSS 787
Query: 965 GPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQ 1024
+ G L L L+ LDL + N I D GV+ L ++L +L+L +
Sbjct: 788 NSI-GDGGAKALAEALKVNQGLESLDLQS---NSISDAGVAALMGALCTNQTLLSLSLRE 843
Query: 1025 NNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKF 1084
N+I+ GA +A AL ++L L L N + D GA ++A + + +L + +Q+N
Sbjct: 844 NSISPEGAQAIAHAL-CANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFI 902
Query: 1085 TAAGAQQLAASLR 1097
A AQ L +L+
Sbjct: 903 QAGAAQALGQALQ 915
Score = 55.8 bits (133), Expect = 2e-07
Identities = 71/269 (26%), Positives = 114/269 (42%), Gaps = 30/269 (11%)
Query: 833 LSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDT 892
L F + A L +AL+ SLDL+S I +G+ +L+G C + +LS
Sbjct: 783 LMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLS-- 840
Query: 893 VALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELP 952
S+ G + A T LK+++ L+ Q R+ +
Sbjct: 841 -LRENSISPEGAQAIAHALCANST--------LKNLDLTANLLHDQGARAIA-------V 884
Query: 953 AVRDLK-----KLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQL 1007
AVR+ + L++ QA + +++ + +SL L EN IGD+G +
Sbjct: 885 AVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLD------LQENAIGDDGACAV 938
Query: 1008 SATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARV 1067
+ +L L L +I GA L EAL ++ +L L L N I GA++LA
Sbjct: 939 ARALKVNTALTALYLQVASIGASGAQVLGEAL-AVNRTLEILDLRGNAIGVAGAKALANA 997
Query: 1068 LPDMVSLRVMDVQYNKFTAAGAQQLAASL 1096
L SLR +++Q N GA +A +L
Sbjct: 998 LKVNSSLRRLNLQENSLGMDGAICIATAL 1026
Score = 37.7 bits (86), Expect = 0.062
Identities = 53/226 (23%), Positives = 86/226 (38%), Gaps = 21/226 (9%)
Query: 833 LSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDT 892
LS ++P A + AL A +LDL + + G ++ + R L+
Sbjct: 839 LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAI---AVAVRENRTLTSL 895
Query: 893 VALWESLQQHGETKLLQAAEEKFTIEPFK--------------AKSLKDVEDLGKL-VQT 937
W +Q L QA + ++ A++LK L L +Q
Sbjct: 896 HLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQV 955
Query: 938 QRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSEN 997
+S GE AV ++ G G L L SSL+ L+L EN
Sbjct: 956 ASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQ---EN 1012
Query: 998 KIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLA 1043
+G +G ++ L+ +NL N+I D GA ++EA+ + A
Sbjct: 1013 SLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNA 1058
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 75.1 bits (183), Expect = 4e-13
Identities = 181/759 (23%), Positives = 278/759 (36%), Gaps = 90/759 (11%)
Query: 371 ERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWA 430
E +S E A DW E Q G A R R + + GK+G GKS A
Sbjct: 246 EEDVRRSFENTAA--DWPEMQTLAG-------AFDSDRWGFRPRTVVLHGKSGIGKSALA 296
Query: 431 GAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHIL 488
+ WA G L Q + +VF +P + R ++ + + + P E+ S
Sbjct: 297 RRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKES-SVTEFISREWPDSQAPVTEIMS--- 352
Query: 489 KRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTAR 548
RP+R+L I+DGF++L + C AE L+ L +K LL L++T R
Sbjct: 353 -RPERLLFIIDGFDDLGSVLNNDTKLCKDW-AEKQPPFTLIRSLLRKVLLPESFLIVTVR 410
Query: 549 PRG-RLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQ-DRALTLLRDRPLLLS 606
G ++S + + G S EQ + G+ EHQ + L + + LL
Sbjct: 411 DVGTEKLKSEVVSPRYLLVRGISGEQR----IHLLLERGIGEHQKTQGLRAIMNNRELLD 466
Query: 607 HSHSPTLCRAVCQLSEALLELGED-AKLPSTLTGLYV----------GLLGRAALDSPPG 655
P + +C + +GE A TLTGL+ G++ R
Sbjct: 467 QCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERV 526
Query: 656 ALAELAKLAWELGRRHQSTLQEDQF---PSADVRTWAMAKGLVQHPPRAAESELAFPSFL 712
L ++A E +S D + A+ + P E F
Sbjct: 527 VLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLS 586
Query: 713 LQCFLGALWLALSG-EIKDKELPQYLALTPR----KKRPYDNWLEGVPRFLAGLIFQPPA 767
LQ F AL+ L G EI+ P Y+ T R K+ + + RFL GL+ +
Sbjct: 587 LQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVR 646
Query: 768 RCLGALLGPSAAASVDRKQKVLARY-LKRLQPGTLRARQLLELLHCAHEAEE-------A 819
R L LLG V KQK+L L QP L+ HC E ++
Sbjct: 647 RPLEVLLGCPVPLGV--KQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLAL 704
Query: 820 GIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGL 879
+Q V + L + + L K F D S CP
Sbjct: 705 NSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRD-ESAEACP--------- 754
Query: 880 SCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQR 939
V LW + L++ E F L+ + DLG + T+R
Sbjct: 755 ------------VVPLWMR-----DKTLIEEQWEDFCSMLGTHPHLRQL-DLGSSILTER 796
Query: 940 TRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKI 999
+ A ++ L F ++ L RI+ A +L+ L+L +
Sbjct: 797 AMKTL--CAKLRHPTCKIQTLMFRNAQIT--PGVQHLWRIVMANRNLRSLNLGG---THL 849
Query: 1000 GDEGVSQLSATFPQLKS-LETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICD 1058
+E V K LE+L L +T K+++ L + + SL LSL N + D
Sbjct: 850 KEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQIL-TTSPSLKSLSLAGNKVTD 908
Query: 1059 VGAESLARVL-PDMVSLRVMDVQYNKFTAAGAQQLAASL 1096
G L+ L +L+ + ++ TA G Q LA++L
Sbjct: 909 QGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASAL 947
Score = 44.3 bits (103), Expect = 7e-04
Identities = 34/98 (34%), Positives = 48/98 (48%), Gaps = 4/98 (4%)
Query: 1004 VSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAES 1063
+SQ+ T P LKSL +L+ N +TD G L++AL +L +L L + I G +S
Sbjct: 886 ISQILTTSPSLKSL---SLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQS 942
Query: 1064 LARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPH 1101
LA L SL + + N G L S+ R PH
Sbjct: 943 LASALVSNRSLTHLCLSNNSLGNEGVNLLCRSM-RLPH 979
Score = 41.6 bits (96), Expect = 0.004
Identities = 45/134 (33%), Positives = 67/134 (50%), Gaps = 10/134 (7%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQL--SATFPQLKSLETLNLSQNNITDLGAY 1033
L L + SL HL LS N +G+EGV+ L S P SL+ L L+Q ++ G
Sbjct: 943 LASALVSNRSLTHL---CLSNNSLGNEGVNLLCRSMRLPHC-SLQRLMLNQCHLDTAGCG 998
Query: 1034 KLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNK--FTAAGAQQ 1091
LA AL + L LSL N + D G + L V+ + S + D++ K TAA +
Sbjct: 999 FLALALMG-NSWLTHLSLSMNPVEDNGVKLLCEVMRE-PSCHLQDLELVKCHLTAACCES 1056
Query: 1092 LAASLRRCPHVETL 1105
L+ + R H+++L
Sbjct: 1057 LSCVISRSRHLKSL 1070
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 71.2 bits (173), Expect = 5e-12
Identities = 104/442 (23%), Positives = 174/442 (39%), Gaps = 46/442 (10%)
Query: 407 HRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAYG 464
+R + + I ++G+AG GK+ A WA G L Q + +VF + CH + +
Sbjct: 222 NRTRAQAQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTF 281
Query: 465 LQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPA---- 520
+ L SL A E F + +P+++L I+DGFEE+ + S +P
Sbjct: 282 AE--LISLDWPDFDAPIEEF---MSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWY 336
Query: 521 EPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADALF-ELSGFSMEQAQAYVM 579
+ + +L L +K+L+ TLL+T + S + F +++GF+ + + Y M
Sbjct: 337 QELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFM 396
Query: 580 RYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQ-LSEALLELGEDAKLPSTLT 638
R+F+ S E + L LR L +P +C VC L + + + + T T
Sbjct: 397 RHFDDSSEVE---KILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTT 453
Query: 639 GLYVGLLGR--------AALDSPPGALAELAKLA----WELG---RRHQSTLQEDQFPSA 683
LY A DS PG L LA W + + + ++ + P
Sbjct: 454 SLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFI 513
Query: 684 DVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALS-------GEIKDKELPQY 736
D ++ + + F Q F A+ L K +E+
Sbjct: 514 D----SLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKML 569
Query: 737 LALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRL 796
L K Y W V F GL+ + AR L L + V + L +
Sbjct: 570 LQHVLLDKEAY--WTP-VVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKA 626
Query: 797 QPGTLRARQLLELLHCAHEAEE 818
+ +L+ +L L HC HE++E
Sbjct: 627 ESASLQF-HILRLFHCLHESQE 647
Score = 41.6 bits (96), Expect = 0.004
Identities = 41/166 (24%), Positives = 68/166 (40%), Gaps = 29/166 (17%)
Query: 984 SSLQHLDLDALSENKIGDEGVSQLSA--TFP---------------------------QL 1014
+S+QH+ L N++ D+G+ L A T P Q
Sbjct: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
Query: 1015 KSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSL 1074
+SL LNLS+N++ D G L EAL +L L+L G LA L ++
Sbjct: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954
Query: 1075 RVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHL 1120
+++D+ N G + L +L+ + TL + + + +HL
Sbjct: 955 KILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHL 1000
Score = 35.8 bits (81), Expect = 0.24
Identities = 26/90 (28%), Positives = 43/90 (47%), Gaps = 1/90 (1%)
Query: 979 ILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEA 1038
+ A S ++ + L EN + D+GV L ++L TL L++ N+T L
Sbjct: 944 LANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSV 1003
Query: 1039 LPSLAASLLRLSLYNNCICDVGAESLARVL 1068
L S + SL+ L+L N + G + L + L
Sbjct: 1004 LSS-SKSLVNLNLLGNELDTDGVKMLCKAL 1032
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 69.3 bits (168), Expect = 2e-11
Identities = 66/229 (28%), Positives = 103/229 (44%), Gaps = 15/229 (6%)
Query: 408 RRP--RETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGL 465
+RP R+ + +A+ G G GK+ A V WA + + + HC +
Sbjct: 196 KRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQ----EVNQT 251
Query: 466 QDLLFS-LGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQ--DGFLHSTCGPAPAEP 522
D FS L Q + ++ S I+ +PD++LL+LDGFEEL + D + P
Sbjct: 252 TDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLP 311
Query: 523 CSLRGLLAGLFQKKLLRGCTLLLTAR-PRGRLVQSLSKADALFELSGFSMEQAQAYVMRY 581
S+ LL+ L K +L TLL+ R + + L K +L L GF+ + Y Y
Sbjct: 312 GSV--LLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMY 369
Query: 582 FESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGED 630
F G TE D+ L+ + +L S P +C VC + +E G +
Sbjct: 370 F---GHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNN 415
Score = 35.4 bits (80), Expect = 0.31
Identities = 38/133 (28%), Positives = 62/133 (46%), Gaps = 8/133 (6%)
Query: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKS-LETLNLSQNNITDLGAYK 1034
L L L HL +L+EN + DEG + P L+ L+ L L + ++T
Sbjct: 859 LASCLRQSKMLTHL---SLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQD 915
Query: 1035 LAEALPSLAASLLRLSLYNNCICDVGAESLARVL--PDMVSLRVMDVQYNKFTAAGAQQL 1092
+ AL +L L L N + D G L L PD +L++++++ FT+ Q +
Sbjct: 916 MISALCK-NKTLKSLDLSFNSLKDDGVILLCEALKNPDC-TLQILELENCLFTSICCQAM 973
Query: 1093 AASLRRCPHVETL 1105
A+ LR+ H+ L
Sbjct: 974 ASMLRKNQHLRHL 986
Score = 34.3 bits (77), Expect = 0.69
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 8/86 (9%)
Query: 1017 LETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRV 1076
L+TL L +N++ + GAY L+ A L RLS+ N + + ESLA L L
Sbjct: 818 LKTLILRKNSLENCGAYYLS------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
Query: 1077 MDVQYNKFTAAGAQQLAASL--RRCP 1100
+ + N GA+ + +L RCP
Sbjct: 872 LSLAENALKDEGAKHIWNALPHLRCP 897
Score = 30.8 bits (68), Expect = 7.6
Identities = 30/101 (29%), Positives = 44/101 (43%), Gaps = 12/101 (11%)
Query: 988 HLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLL 1047
HL L +N + + G LS + S+E NL+Q L LA L + L
Sbjct: 817 HLKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQ-----LTCESLASCLRQ-SKMLT 870
Query: 1048 RLSLYNNCICDVGAESLARVLPDM------VSLRVMDVQYN 1082
LSL N + D GA+ + LP + + LR D+ +N
Sbjct: 871 HLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFN 911
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 62.4 bits (150), Expect = 2e-09
Identities = 65/237 (27%), Positives = 107/237 (45%), Gaps = 19/237 (8%)
Query: 416 IAVLGKAGQGKSYWAGAVSRAWACGRL--PQYDFVFSVPCHCLNRPGDAYGLQDLLFSLG 473
+ + G G GK+ V WA G L ++ FVF + +N + L +LL
Sbjct: 148 VVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAET-SLLELLSRDW 206
Query: 474 PQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLF 533
P+ +++FS +P+R+L I+DGFE+L+ + L + + + +L+ L
Sbjct: 207 PESSEKIEDIFS----QPERILFIMDGFEQLKF-NLQLKADLSDDWRQRQPMPIILSSLL 261
Query: 534 QKKLLRGCTLLLTARPRGRLVQS----LSKADALFELSGFSMEQAQAYVMRYFESSGMTE 589
QKK+L +LL+ G+L + + L +L GFS + ++Y +F G
Sbjct: 262 QKKMLPESSLLIAL---GKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFF---GEKS 315
Query: 590 HQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPS-TLTGLYVGLL 645
+ +RD L H+P C VC + LE GED ++ S T LY L
Sbjct: 316 KALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFL 372
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 61.6 bits (148), Expect = 4e-09
Identities = 94/398 (23%), Positives = 162/398 (40%), Gaps = 38/398 (9%)
Query: 401 LLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLN-RP 459
L A KE ++ R + + G G GK+ + AW+ ++ + F+++ C R
Sbjct: 138 LFAPKE--AGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRE 195
Query: 460 GDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAP 519
L DL+ P P E+ S +P+R+L ++D FEEL+ S
Sbjct: 196 LPPTSLADLISREWPDPAAPITEIVS----QPERLLFVIDSFEELQGGLNEPDSDLCGDL 251
Query: 520 AEPCSLRGLLAGLFQKKLLRGCTLLLTARP-RGRLVQSLSKADALFELSGFSMEQAQAYV 578
E ++ LL+ L +KK+L +LL+ +P + ++ +++ GF+ Y
Sbjct: 252 MEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYF 311
Query: 579 MRYFESSGMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLP-STL 637
+F+ + A L+R+ L S P LC +C + ++ G+D L +
Sbjct: 312 CCFFKD---PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQST 368
Query: 638 TGLYVGLLGRAALDSPPGA----------LAELAKLA----W-ELGRRHQSTLQEDQFPS 682
T +Y + L +P GA L L LA W + + L+ +
Sbjct: 369 TSVYSSFVFN--LFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVD 426
Query: 683 ADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELP-----QYL 737
AD+ K L+++ R ES F +Q F AL+ L + D P Q L
Sbjct: 427 ADIPALLGTKILLKYGER--ESSYVFLHVCIQEFCAALFYLLKSHL-DHPHPAVRCVQEL 483
Query: 738 ALTPRKKRPYDNWLEGVPRFLAGLIFQPPARCLGALLG 775
+ +K +W+ + FL GL+ + L A G
Sbjct: 484 LVANFEKARRAHWI-FLGCFLTGLLNKKEQEKLDAFFG 520
Score = 37.4 bits (85), Expect = 0.081
Identities = 27/82 (32%), Positives = 37/82 (45%)
Query: 1015 KSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSL 1074
KS+ L+LS N + D G L EAL L L L I G E LA L +L
Sbjct: 807 KSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNL 866
Query: 1075 RVMDVQYNKFTAAGAQQLAASL 1096
+++ + N+ G Q L +L
Sbjct: 867 KILQIGCNEIGDVGVQLLCRAL 888
Score = 32.7 bits (73), Expect = 2.0
Identities = 34/118 (28%), Positives = 51/118 (43%), Gaps = 5/118 (4%)
Query: 934 LVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDA 993
LV+ T + ED A L + ++LK L+ + G L R LT L++
Sbjct: 843 LVKCFITAAGCEDLASALISNQNLKILQIGCNEI-GDVGVQLLCRALTHTDC--RLEILG 899
Query: 994 LSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEAL--PSLAASLLRL 1049
L E + L++ K+L+ LNL+ N + G L EAL P A +L L
Sbjct: 900 LEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 56.2 bits (134), Expect = 2e-07
Identities = 99/449 (22%), Positives = 179/449 (39%), Gaps = 50/449 (11%)
Query: 412 ETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQ--YDFVFSVPCHCLNRPGDAYGLQDLL 469
+ +++ + G AG GK+ WA G L Q + +VF + +N+ L++
Sbjct: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQ------LKERS 228
Query: 470 FS-LGPQPLVAADEVFSHILKRPDRVLLILDGFEELE-AQDGFLHSTCGPAPAE-PCSLR 526
F+ L + + + I+ +P +L I+D F+EL A + + C E P S
Sbjct: 229 FAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSF- 287
Query: 527 GLLAGLFQKKLLRGCTLLLTAR-PRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESS 585
L++ L +K +L +LL+T R + ++ L K EL G S + + Y+ ++FE
Sbjct: 288 -LMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDK 346
Query: 586 GMTEHQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLP-STLTGLYVGL 644
+ + L+ +L S P +C A C + +E G D L T T L+
Sbjct: 347 RWAM---KVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCY 403
Query: 645 LGRAALDSPPGA-----LAELAKLAWELGRR--------HQSTLQEDQFPSADVRTWAMA 691
+ G+ A+L +L + ++ L+ +DV ++ M
Sbjct: 404 ISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSF-MD 462
Query: 692 KGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKD--------KELPQYLALTPRK 743
++Q E+ F +Q F A++ L G + ++L L T K
Sbjct: 463 SNIIQKDAEY-ENCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYK 521
Query: 744 KRPYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRA 803
D L + FL GL+ + + L + + K L + ++ L
Sbjct: 522 ----DPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSK---LLQCMEVLGNSDYSP 574
Query: 804 RQL--LELLHCAHEAEEAGIWQHVVQELP 830
QL LEL HC +E ++ ++ P
Sbjct: 575 SQLGFLELFHCLYETQDKAFISQAMRCFP 603
Score = 34.7 bits (78), Expect = 0.53
Identities = 36/113 (31%), Positives = 44/113 (38%), Gaps = 32/113 (28%)
Query: 985 SLQHLDLDALSENKIGDEGVSQLSATF--PQLK--------------------------- 1015
+L HLDL + IGD GV L P+ K
Sbjct: 730 NLMHLDLKG---SDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQ 786
Query: 1016 SLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLARVL 1068
SL LNLS NN+ D G L EAL L RLSL + + + G E L+ L
Sbjct: 787 SLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLAL 839
>gi|25777608 NLR family member X1 isoform 1 [Homo sapiens]
Length = 975
Score = 56.2 bits (134), Expect = 2e-07
Identities = 96/398 (24%), Positives = 141/398 (35%), Gaps = 49/398 (12%)
Query: 308 RANMTEHKTSPTQCPAAGEVSNKLPKWP--EPVEQFYRSLQDTYGAEPA-----GPDGIL 360
RA + H +S P G P E +++ R+L + + P GP L
Sbjct: 47 RAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFAL 106
Query: 361 --VEVDLVQARLERSSSKSLER---ELATPDWAERQLAQGGLAEVLLAA--KEHRRPRET 413
V VD V + S+ L R ELA E Q Q GL + L+ R
Sbjct: 107 DTVHVDPV---IRESTPDELLRPPAELAL----EHQPPQAGLPPLALSQLFNPDACGRRV 159
Query: 414 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLG 473
+ + + G G GKS + W GRLP ++ + C L+ G A L L
Sbjct: 160 QTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPA---PASLCQLV 216
Query: 474 PQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLF 533
Q EV + +L +L G E L + P EP ++ L
Sbjct: 217 AQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLL 276
Query: 534 QKKLLRGCTLLLTARPR----------GRLVQSLSKADALFELSGFSMEQAQAYVMRYFE 583
+K +L ++L+T RP GR + +D + F + Q Y
Sbjct: 277 RKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVG 336
Query: 584 SSGM--TEHQDRALTLLRDRPLLLSHSHS-----PTLCRAVCQLSEALLELGEDAKLPST 636
SG+ T Q L + R L H + P+ C VC L L T
Sbjct: 337 GSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVC---ATLHFLHAPTPAGQT 393
Query: 637 LTGLYVGLL-----GRAALDSPPGALAELAKLAWELGR 669
LT +Y L G + P L+ +A A +G+
Sbjct: 394 LTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGK 431
Score = 42.7 bits (99), Expect = 0.002
Identities = 72/320 (22%), Positives = 118/320 (36%), Gaps = 52/320 (16%)
Query: 746 PYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQ 805
P D E P F+ GL+ L L P + + + L +L L +
Sbjct: 615 PEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSE 674
Query: 806 LLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFS-LDLR 864
LL+ L +E + V+ L +L+ G R+TP V+ L + ++L
Sbjct: 675 LLDHLFFHYEFQNQRFSAEVLSSLR-QLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLA 733
Query: 865 STGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKS 924
S + P+GL +L+ + L+A + + ++
Sbjct: 734 SCQLDPAGLRTLLPV---------------------------FLRARKLGLQLNSLGPEA 766
Query: 925 LKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFS 984
KD+ DL Q Q T L + P++ L+ L +
Sbjct: 767 CKDLRDLLLHDQCQITT------------------LRLSNNPLTAA-GVAVLMEGLAGNT 807
Query: 985 SLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAA 1044
S+ HL +L +GDEG+ L+A + + L+ LN++ N D A LA A
Sbjct: 808 SVTHL---SLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAARE-HP 863
Query: 1045 SLLRLSLYNNCICDVGAESL 1064
SL L LY N + G + L
Sbjct: 864 SLELLHLYFNELSSEGRQVL 883
Score = 40.0 bits (92), Expect = 0.013
Identities = 36/116 (31%), Positives = 49/116 (42%), Gaps = 2/116 (1%)
Query: 994 LSENKIGDEGVSQL-SATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLY 1052
L N +G E L + TL LS N +T G L E L S+ LSL
Sbjct: 757 LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAG-NTSVTHLSLL 815
Query: 1053 NNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMW 1108
+ + D G E LA L L+ ++V YN A LA + R P +E L ++
Sbjct: 816 HTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLY 871
>gi|25777610 NLR family member X1 isoform 2 [Homo sapiens]
Length = 921
Score = 56.2 bits (134), Expect = 2e-07
Identities = 96/398 (24%), Positives = 141/398 (35%), Gaps = 49/398 (12%)
Query: 308 RANMTEHKTSPTQCPAAGEVSNKLPKWP--EPVEQFYRSLQDTYGAEPA-----GPDGIL 360
RA + H +S P G P E +++ R+L + + P GP L
Sbjct: 47 RAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFAL 106
Query: 361 --VEVDLVQARLERSSSKSLER---ELATPDWAERQLAQGGLAEVLLAA--KEHRRPRET 413
V VD V + S+ L R ELA E Q Q GL + L+ R
Sbjct: 107 DTVHVDPV---IRESTPDELLRPPAELAL----EHQPPQAGLPPLALSQLFNPDACGRRV 159
Query: 414 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLG 473
+ + + G G GKS + W GRLP ++ + C L+ G A L L
Sbjct: 160 QTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPA---PASLCQLV 216
Query: 474 PQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLF 533
Q EV + +L +L G E L + P EP ++ L
Sbjct: 217 AQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLL 276
Query: 534 QKKLLRGCTLLLTARPR----------GRLVQSLSKADALFELSGFSMEQAQAYVMRYFE 583
+K +L ++L+T RP GR + +D + F + Q Y
Sbjct: 277 RKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVG 336
Query: 584 SSGM--TEHQDRALTLLRDRPLLLSHSHS-----PTLCRAVCQLSEALLELGEDAKLPST 636
SG+ T Q L + R L H + P+ C VC L L T
Sbjct: 337 GSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVC---ATLHFLHAPTPAGQT 393
Query: 637 LTGLYVGLL-----GRAALDSPPGALAELAKLAWELGR 669
LT +Y L G + P L+ +A A +G+
Sbjct: 394 LTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGK 431
Score = 40.4 bits (93), Expect = 0.010
Identities = 64/294 (21%), Positives = 108/294 (36%), Gaps = 51/294 (17%)
Query: 746 PYDNWLEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQ 805
P D E P F+ GL+ L L P + + + L +L L +
Sbjct: 615 PEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSE 674
Query: 806 LLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFS-LDLR 864
LL+ L +E + V+ L +L+ G R+TP V+ L + ++L
Sbjct: 675 LLDHLFFHYEFQNQRFSAEVLSSLR-QLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLA 733
Query: 865 STGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKS 924
S + P+GL +L+ + L+A + + ++
Sbjct: 734 SCQLDPAGLRTLLPV---------------------------FLRARKLGLQLNSLGPEA 766
Query: 925 LKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFS 984
KD+ DL Q Q T L + P++ L+ L +
Sbjct: 767 CKDLRDLLLHDQCQITT------------------LRLSNNPLTAA-GVAVLMEGLAGNT 807
Query: 985 SLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEA 1038
S+ HL +L +GDEG+ L+A + + L+ LN++ N D A LA A
Sbjct: 808 SVTHL---SLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARA 858
Score = 40.4 bits (93), Expect = 0.010
Identities = 40/138 (28%), Positives = 53/138 (38%), Gaps = 19/138 (13%)
Query: 994 LSENKIGDEGVSQL-SATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLY 1052
L N +G E L + TL LS N +T G L E L S+ LSL
Sbjct: 757 LQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAG-NTSVTHLSLL 815
Query: 1053 NNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLA------ 1106
+ + D G E LA L L+ ++V YN A LA + R P +E L
Sbjct: 816 HTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLQGVAIQM 875
Query: 1107 -----------MWTPTIP 1113
+WTP +P
Sbjct: 876 CWKLPLLPYAHLWTPRMP 893
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,042,517
Number of Sequences: 37866
Number of extensions: 2373433
Number of successful extensions: 8439
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 179
Number of HSP's that attempted gapping in prelim test: 7656
Number of HSP's gapped (non-prelim): 799
length of query: 1130
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1017
effective length of database: 13,968,660
effective search space: 14206127220
effective search space used: 14206127220
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.