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Search of human proteins with 154354987
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
(717 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|154354987 hook homolog 2 isoform 2 [Homo sapiens] 1402 0.0
gi|154354985 hook homolog 2 isoform 1 [Homo sapiens] 1397 0.0
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 681 0.0
gi|7705415 hook homolog 1 [Homo sapiens] 635 0.0
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 135 1e-31
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 129 7e-30
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 129 7e-30
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 103 7e-22
gi|16262452 cingulin [Homo sapiens] 103 7e-22
gi|21735548 centrosomal protein 2 [Homo sapiens] 102 9e-22
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 99 2e-20
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 99 2e-20
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 99 2e-20
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 99 2e-20
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 99 2e-20
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 99 2e-20
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 99 2e-20
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 99 2e-20
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 96 9e-20
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 96 9e-20
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 96 9e-20
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 95 2e-19
gi|148746195 trichohyalin [Homo sapiens] 92 2e-18
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 91 4e-18
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 90 8e-18
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 89 1e-17
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 89 2e-17
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 88 2e-17
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 88 3e-17
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 87 4e-17
>gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
Length = 717
Score = 1402 bits (3630), Expect = 0.0
Identities = 717/717 (100%), Positives = 717/717 (100%)
Query: 1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED 60
MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
Sbjct: 1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED 60
Query: 61 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG 120
PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
Sbjct: 61 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG 120
Query: 121 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL 180
CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
Sbjct: 121 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL 180
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
Sbjct: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
Sbjct: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
Query: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
Sbjct: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
Query: 361 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE 420
QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
Sbjct: 361 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE 420
Query: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
Sbjct: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
Query: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK 540
RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK
Sbjct: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK 540
Query: 541 LEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRR 600
LEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRR
Sbjct: 541 LEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRR 600
Query: 601 YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL 660
YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL
Sbjct: 601 YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL 660
Query: 661 LISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH 717
LISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
Sbjct: 661 LISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH 717
>gi|154354985 hook homolog 2 isoform 1 [Homo sapiens]
Length = 719
Score = 1397 bits (3617), Expect = 0.0
Identities = 717/719 (99%), Positives = 717/719 (99%), Gaps = 2/719 (0%)
Query: 1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED 60
MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED
Sbjct: 1 MSVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISED 60
Query: 61 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG 120
PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG
Sbjct: 61 PGPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLG 120
Query: 121 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL 180
CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL
Sbjct: 121 CAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFL 180
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL
Sbjct: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL
Sbjct: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
Query: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA
Sbjct: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
Query: 361 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE 420
QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE
Sbjct: 361 QLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEE 420
Query: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE
Sbjct: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
Query: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED--SILLK 538
RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED SILLK
Sbjct: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLK 540
Query: 539 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 598
RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY
Sbjct: 541 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 600
Query: 599 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 658
RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE
Sbjct: 601 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 660
Query: 659 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH 717
KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH
Sbjct: 661 KLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDKH 719
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 681 bits (1756), Expect = 0.0
Identities = 359/716 (50%), Positives = 517/716 (72%), Gaps = 8/716 (1%)
Query: 2 SVDKAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDP 61
S+++AELC SLLTW+QTF+V +PC + +DL++G+ +A VL +IDP++F+E WL I +
Sbjct: 6 SLERAELCESLLTWIQTFNVDAPCQTVEDLTNGVVMAQVLQKIDPAYFDENWLNRIKTEV 65
Query: 62 GPNWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGC 121
G NW+LK+SNLK +L+ +++Y+ ++L +++ LPDV+LIGE SD AELG++LQL+LGC
Sbjct: 66 GDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHSDAAELGRMLQLILGC 125
Query: 122 AISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRR-YYFL 180
A++CE+KQ++IQ IM +EESVQHVVM AIQELM+K++P S + Y + D Q ++ L
Sbjct: 126 AVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAGNDAYVDLDRQLKKTTEEL 185
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-KKLL 239
+E +E+ QRC +L+ Q+ L EEK SL EN L ER+ + + P A ++ L
Sbjct: 186 NEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHL 245
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
LQ+QLEQLQEE FRLE+ ++D R+RC ELE+E++EL+ +N LT+LA EAQ+LKDE+D
Sbjct: 246 QLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDV 305
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLR 359
LR SS++ +LE + S +++L +L +LRRQV+ LEE+N + + T LE+ELR+A + R
Sbjct: 306 LRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAAR 365
Query: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
+QLE +RQV ELQ + EE+ KA+K FE + L+EK +S+ KEK+RL ERDSL+E E
Sbjct: 366 SQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIE 425
Query: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRL-CRQEAAD 478
ELRC Q Q LT + D+LAAEI+ E+RE L+RLQ ENK L QE +D
Sbjct: 426 ELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSD 485
Query: 479 RERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLK 538
E+ LQ L+DAN ++ LET++RL Q+L E+++QVE+LQK+LQ+QG K EDS+LLK
Sbjct: 486 NEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLK 545
Query: 539 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 598
+KLEEHL+KLHEA+ ELQ+KR IE+LEP ++S+ +IEELQ L+KK+ +++ MEERY
Sbjct: 546 KKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSL-KIEELQEALRKKEEEMKQMEERY 604
Query: 599 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 658
++Y++KA+ V++T++PKQ GA PE+ +L+ QL+ERD LE ++EK++SQRE EE
Sbjct: 605 KKYLEKAKSVIRTLDPKQN--QGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEE 662
Query: 659 KLLISAWYNMGMALQQRAGEER--APAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
K ++SAWYNMGM L ++A E+R + QSFLA+QR AT+SRR G + R
Sbjct: 663 KYIVSAWYNMGMTLHKKAAEDRLASTGSGQSFLARQRQATSSRRSYPGHVQPATAR 718
>gi|7705415 hook homolog 1 [Homo sapiens]
Length = 728
Score = 635 bits (1638), Expect = 0.0
Identities = 347/714 (48%), Positives = 488/714 (68%), Gaps = 26/714 (3%)
Query: 5 KAELCGSLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGPN 64
K LC SL+ WLQTF+ SPC + L+SG+A+A VL+QID +WFNE+WL I ED G N
Sbjct: 11 KLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWLSRIKEDVGDN 70
Query: 65 WKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVLGCAIS 124
W++K SN+K VL+ ++ Y + L +SE +PD++ I E SDP ELG+LLQL+LGCAI+
Sbjct: 71 WRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRLLQLILGCAIN 130
Query: 125 CEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYF-LSEE 183
CEKKQ+HIQ IMTLEESVQHVVM AIQELM+K+ S + G + Q +R L E
Sbjct: 131 CEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQLKRALEELQEA 190
Query: 184 AEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG--EGTPGLTAKKLLLL 241
E +EL+QRC +L+ Q+ L +EK SL EN + E++ + +G + + AKK
Sbjct: 191 LAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTVVAKKYFHA 250
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
Q QLEQLQEENFRLE+ ++D R+ C ELE+++ E QHRN LTSLA+E +ALKDE+D LR
Sbjct: 251 QLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLR 310
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
+S++A +LE+T+ R++L +L +LR+QV+ L+E N + T LE+EL++A + R Q
Sbjct: 311 ATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEELKKANAARTQ 370
Query: 362 LEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEEL 421
LE +RQVQ+L + E+ +A+ FE + LEEK+E++ KEKERL+ +RD+L+E NEEL
Sbjct: 371 LETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEEL 430
Query: 422 RCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRL-CRQEAADRE 480
RC+Q+Q L Q D S + +NLAAEI+P E RE +RLQ ENK L +QE ++ E
Sbjct: 431 RCSQVQQDHLNQTDAS---ATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENE 487
Query: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKT--EDSILLK 538
R EELQ LE +R + LET+ RL+++++ EL+ Q+EDLQK+LQEQG K+ E S LK
Sbjct: 488 RIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEGESSSKLK 547
Query: 539 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 598
+KLE H++KL E ELQ+K+E IE+L+P + + ++I EL+ LQKKD D++AMEERY
Sbjct: 548 QKLEAHMEKLTEVHEELQKKQELIEDLQPDINQN-VQKINELEAALQKKDEDMKAMEERY 606
Query: 599 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 658
+ Y++KAR V++T++PK PA+ E+ LR QL E++ RI LE + + ++ R+ EE
Sbjct: 607 KMYLEKARNVIKTLDPKLNPASA---EIMLLRKQLAEKERRIEILESECKVAKF-RDYEE 662
Query: 659 KLLISAWYNMGMALQQRAGEER------------APAHAQSFLAQQRLATNSRR 700
KL++SAWYN +A Q+ E R A A+SFLAQQR TN+RR
Sbjct: 663 KLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRR 716
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 135 bits (341), Expect = 1e-31
Identities = 186/762 (24%), Positives = 319/762 (41%), Gaps = 154/762 (20%)
Query: 12 LLTWLQTFHVPSPCASPQ------DLSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGPNW 65
L+TW++TF P S DL G+ + ++ QIDP N+ + ++ D
Sbjct: 17 LVTWVKTFG-PFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHVNNDVN--- 72
Query: 66 KLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPA------ELGKLLQLVL 119
L++ NL +++R++ Y Q+VL + +LP+V +IG DP E+ K+L LVL
Sbjct: 73 -LRIQNLTILVRNIKTYYQEVLQQLIVM-NLPNVLMIGR--DPLSGKSMEEIKKVLLLVL 128
Query: 120 GCAISCEKKQDHIQRIMTLEESVQHVVMEAIQE----------LMTKDTPDSLSPETYGN 169
GCA+ CE+K++ I+RI L+ Q ++ IQE L + PD ++PE
Sbjct: 129 GCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPD-VAPE---E 184
Query: 170 FDSQSRRYYF-LSEEAEEGDELQQRCLDL--ERQLM-----------------------L 203
++ SR L ++ DE + +DL ER + L
Sbjct: 185 LEALSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSL 244
Query: 204 LSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDER 263
SE+KQ LA E A + R+ R E L+ + EQL D R
Sbjct: 245 SSEDKQHLAVELADTKARLRRVRQE------------LEDKTEQLV-----------DTR 281
Query: 264 LRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGE 323
+L E+ +++ N L + A+ A+A +DE+D LR+ + R +LE LT C+ +L +
Sbjct: 282 HEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRCKEKLHD 341
Query: 324 LRELRRQVRQLEERNAGHAERTRQLEDEL---RRAGSLRAQLEAQRRQVQ----ELQGQR 376
+ + ++ +L E N E LE++L R G +LE + Q++ +L+ R
Sbjct: 342 VDFYKARMEELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLKSKLHDLELDR 401
Query: 377 QEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR---------------EANE-- 419
+ + E+ L E LE + E L E + L E NE
Sbjct: 402 DTDKKRIEELLEENMVLEIAQKQSMNESAHLGWELEQLSKNADLSDASRKSFVFELNECA 461
Query: 420 ---------ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKR 470
E + Q +GL A L+ + L E + L+ QLE ++
Sbjct: 462 SSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREK 521
Query: 471 LCRQE----------------------AADRERQ-EELQRHLEDANRARHGLETQHRLNQ 507
Q+ AD+ RQ ++L++ + NRA L + +++
Sbjct: 522 QSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSS 581
Query: 508 Q-QLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHE-------ADLELQRKR 559
+ ++ ++ + + L + + E GK KR+L L++ E + ELQR +
Sbjct: 582 EARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQ 641
Query: 560 EYIEELEPPTDS--STARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQR 617
E L S + ++E L+H Q + R + R+ +D + V +E +R
Sbjct: 642 EENGRLARKVTSLETATEKVEALEHESQGLQLENRTL----RKSLDTLQNVSLQLEGLER 697
Query: 618 PAAGAPPELHSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEE 658
E LR + R + +M+ E + +RE+EE
Sbjct: 698 DNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEE 739
Score = 69.3 bits (168), Expect = 1e-11
Identities = 124/586 (21%), Positives = 224/586 (38%), Gaps = 61/586 (10%)
Query: 140 ESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLER 199
E H + + I++L T+ L E N D ++ + E+ + +++ D R
Sbjct: 500 EKENHQLSKKIEKLQTQ-----LEREKQSNQDLETLSEELIREKEQLQSDMETLKADKAR 554
Query: 200 QLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS------QLEQLQEENF 253
Q+ L +EK L + LRER + + L Q+ +L QL+ E
Sbjct: 555 QIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKR 614
Query: 254 RLESGREDERL---RCAELEREVAELQHRNQALT--------------SLAQEAQALKDE 296
+L E + R +LERE+ LQ N L +L E+Q L+ E
Sbjct: 615 QLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHESQGLQLE 674
Query: 297 MDELRQSSER----AGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LR+S + + QLE ++ E ELRR V + + A+ R+ +
Sbjct: 675 NRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLE 734
Query: 353 RRAGSLRAQ---LEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
R LR L+A ++ + L+ Q + + + + K +++ E L A
Sbjct: 735 REKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLESELGELEA 794
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
ER +LR E LR A Q G + D A E A+L + L+ E K
Sbjct: 795 ERQALRRDLEALRLANAQLEGAEK------------DRKALEQEVAQLEKDKKLLEKEAK 842
Query: 470 RLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
RL +Q E L+D+ +E + R ++L+ R L++ ++
Sbjct: 843 RLWQQ-------VELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRD 895
Query: 530 KTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDA 589
T+ + R L + L L+ Q+ +++L + R LQ + D
Sbjct: 896 LTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDT 955
Query: 590 DLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEK 649
+ +E R + T+ K+ ++ + R+ + ++ L+ + E
Sbjct: 956 KYKILEGR------NESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECET 1009
Query: 650 SRSQREQEEKLLISAWYNMGMALQQRAGEER-APAHAQSFLAQQRL 694
R + + + L S + G G+E P H ++ + R+
Sbjct: 1010 LRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRV 1055
Score = 66.2 bits (160), Expect = 1e-10
Identities = 88/401 (21%), Positives = 168/401 (41%), Gaps = 39/401 (9%)
Query: 184 AEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ E D+L Q + LL +E S + + E + T + +K++LL++
Sbjct: 925 SSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEA 984
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQAL---------- 293
Q+E+ N +LES + + C L + E QH + A + A
Sbjct: 985 QMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPG 1044
Query: 294 -KDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAER--TRQLED 350
K+ EL + +RA +LE + + E + L+ Q++ LE +N + + T Q +
Sbjct: 1045 HKEATMELLRVKDRAIELERNNAALQ---AEKQLLKEQLQHLETQNVTFSSQILTLQKQS 1101
Query: 351 ELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNL--EEKYESVTKEKERLL 408
+ + Q + + QV+ Q A+ A+ L + + E + ES+ +++E+L
Sbjct: 1102 AFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLT 1161
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLEN 468
A ++L + +E L L R + + + S L+ L+LE+
Sbjct: 1162 AAYEALLQDHEHL--GTLHERQSAEYEALIRQHSC-------------LKTLHRNLELEH 1206
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSE---LRAQVEDLQKALQ 525
K L + +R+ EL+ + R L+ + R N + E LR +++ +
Sbjct: 1207 KELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHH 1266
Query: 526 EQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELE 566
+ G+ E+ L +E L+ A LEL R + +EL+
Sbjct: 1267 QLKGEYEE---LHAHTKELKTSLNNAQLELNRWQARFDELK 1304
Score = 57.8 bits (138), Expect = 3e-08
Identities = 86/359 (23%), Positives = 150/359 (41%), Gaps = 62/359 (17%)
Query: 190 LQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLT-AKKLLLLQSQLEQL 248
++ R ++LER L EKQ L ++ L T +T + ++L LQ Q L
Sbjct: 1055 VKDRAIELERNNAALQAEKQLLKEQLQHLE----------TQNVTFSSQILTLQKQSAFL 1104
Query: 249 QEENFRLESGREDERLRCAELEREVAELQHRNQALT------------------SLAQEA 290
QE N L++ + A+L+ E + L ++ ALT SL ++
Sbjct: 1105 QEHNTTLQT-------QTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQ 1157
Query: 291 QALKDEMDELRQSSERAGQL--------EATLT--SCRRRLGELRELRRQVRQLEERNAG 340
+ L + L Q E G L EA + SC + L R L + ++L ER+
Sbjct: 1158 EQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLH--RNLELEHKELGERHGD 1215
Query: 341 HAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESV 400
+R +LE+ + + R L+ ++R G+ Q + ++ F L+ +YE +
Sbjct: 1216 MLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEEL 1275
Query: 401 TKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEI------LP 454
+ L + SL A EL Q + L + ++D + T +DN + L
Sbjct: 1276 HAHTKEL---KTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRLKGNLE 1332
Query: 455 AELRETLLRLQL---ENKRLCRQEAADRERQEELQRHLEDANRA--RHGLETQHRLNQQ 508
E L ++QL +N+ L Q ++E+ E Q+ D A RH + + ++ Q
Sbjct: 1333 EENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQ 1391
Score = 30.8 bits (68), Expect = 4.6
Identities = 50/274 (18%), Positives = 106/274 (38%), Gaps = 32/274 (11%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL 241
E E ++ +R +LE + +L+ E+++L QE + T L + L
Sbjct: 1208 ELGERHGDMLKRKAELEEREKVLTTEREALQQE-------------QRTNALAMGENQRL 1254
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREV----AELQHRNQALTSLAQEAQALKDEM 297
+ +L+++ + +L+ E+ EL+ + EL L ++ Q + +
Sbjct: 1255 RGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISL 1314
Query: 298 DELRQSSERAGQLEATLTSCRRR-LGELRELRRQVRQLEERNAGHAERTRQLEDE-LRRA 355
+L E +L+ L L +++ L +Q + L E+N + E+ + + + + +
Sbjct: 1315 TKLDNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKL 1374
Query: 356 GSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR 415
+LR E ++ + K W+ ++ +ERL + DS
Sbjct: 1375 NALRRHKEKLEEKIMDQYKFYDPPPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDS-- 1432
Query: 416 EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLA 449
P L +DP+ S P+ + A
Sbjct: 1433 -----------PPWQLESSDPASPAASQPLRSQA 1455
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 129 bits (325), Expect = 7e-30
Identities = 175/742 (23%), Positives = 332/742 (44%), Gaps = 114/742 (15%)
Query: 12 LLTWLQTFHVPSPCASPQD--------LSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGP 63
L+TW++TF P A+ L G+ + V+ QI+P ++ + ++ D
Sbjct: 18 LVTWVKTF---GPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKVNNDAS- 73
Query: 64 NWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGE--FSDPA--ELGKLLQLVL 119
L++ NL +++R + Y Q+ L + LP+V +IG+ FS+ E+ KLL L+L
Sbjct: 74 ---LRMHNLSILVRQIKFYYQETLQQLIMMS-LPNVLIIGKNPFSEQGTEEVKKLLLLLL 129
Query: 120 GCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYF 179
GCA+ C+KK++ I+RI L+ + V IQE+ FD Q
Sbjct: 130 GCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE---------NVFDLQWMEVTD 180
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQS---LAQENAGLR----ERMGRPEGEGTPG 232
+S+E E L+ L L+R + E ++ L++E GL G+PG
Sbjct: 181 MSQEDIE-PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 233 LT--------AKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALT 284
+ + +L ++++ +L++E D + ++E E+ LQ N L
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 285 SLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAER 344
S A+ A+ +DE+D LR+ + R +LE+ ++ + RL ++ + +V +L+E N E
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 345 TRQLEDELR--RAGS------------LRAQL-------EAQRRQVQELQGQRQEEAMKA 383
LED+L RA S L+A+L + R++++EL + M
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 384 EKWLFECRNLEEKYESVTKEKERLLAERDSL-REANE----ELRCAQLQPRGLTQADPSL 438
++ + E +L + E +++ E A + SL E NE L +++ + LT+ L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479
Query: 439 DPTSTPVDNLAAEILPAEL-------------------RETLLRLQLENKRLCRQEA--- 476
T V+ A++IL E +++L Q +K L +++A
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 477 ----ADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQK-------ALQ 525
RE E + LE N H +T L Q+ A+V+D++K +++
Sbjct: 540 KTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 526 EQGGKTEDSILLKRKLE---EHLQKLHEADLELQRKREYIE-ELEPPTDSSTARRIE-EL 580
E K KR+++ EH ++ E EL+ + ++E E E T +I E
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK 657
Query: 581 QHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLR---TQLRERD 637
L++++++L + ++ +D + + +E ++ + E LR L+
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS 717
Query: 638 VRIRHLEMDFEKSRSQREQEEK 659
+++ L+++ ++ S++EQ +K
Sbjct: 718 MKMAQLQLENKELESEKEQLKK 739
Score = 70.5 bits (171), Expect = 5e-12
Identities = 103/504 (20%), Positives = 217/504 (43%), Gaps = 58/504 (11%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
+E L + + +L + EK+ + +E +E+ R E L+++
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE-------------LENE 633
Query: 245 LEQLQEENFRLESGREDERLRCAE---LEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
L L++EN L+ + ++ C + LE+E +EL+ N+ L + L +++ L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
+ + QL+ RR + L+ ++ QL+ N ++LE E +
Sbjct: 694 KEN---SQLDEENLELRRNVESLKCASMKMAQLQLEN-------KELESEKEQLKKGLEL 743
Query: 362 LEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEEL 421
L+A ++ + L+ Q ++ ++ N +K + + E + L E +L++ EEL
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 422 RCAQLQPRGLTQADPSLDPTSTPVDNLAAEI--------LPAELRETLL--------RLQ 465
+ + + L + + SL+ ++ ++ ++ AE+++T L L+
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 466 LENKRLCRQEAADRE---RQEELQR-HLEDANRARHGLETQHRLNQQQLSE------LRA 515
ENK L ++ +E R +EL++ + E RA ++T L + +SE +
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 516 QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTAR 575
+E L L++ G E + ++ ++ KL E+ LE K+ E++ ++
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL--EIKEEKIAALEA 981
Query: 576 RIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPP--ELHSLRTQL 633
R+EE + Q+ +L+ +++ Y K R + M P +G E S T
Sbjct: 982 RLEESTNYNQQLRQELKTVKKNYEAL--KQRQDEERMVQSSPPISGEDNKWERESQETTR 1039
Query: 634 RERDVRIRHLEMDFEKSRSQREQE 657
V+ R +E++ + Q E++
Sbjct: 1040 ELLKVKDRLIEVERNNATLQAEKQ 1063
Score = 53.9 bits (128), Expect = 5e-07
Identities = 113/505 (22%), Positives = 203/505 (40%), Gaps = 87/505 (17%)
Query: 180 LSEEAEEGDELQQRC-LDLERQLML---LSEEKQSLAQENAGLRERMGRPEGEGTPGLTA 235
L E +E EL +R +D++ + L L EK Q N L + E GL
Sbjct: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE---KIGLNK 939
Query: 236 KKLL------------LLQSQLEQLQEENFRLESGREDERLRCAE--LEREVAELQHRNQ 281
++LL LL+S+LE +++ ++ +E++ E LE Q Q
Sbjct: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK----EEKIAALEARLEESTNYNQQLRQ 995
Query: 282 ALTSLAQEAQALKDEMDELRQ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN 338
L ++ + +ALK DE R S +G+ + EL +++ ++ ++E N
Sbjct: 996 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 339 AGHAERTRQLEDELRRA----GSLRAQLEAQRRQVQELQGQR-----QEEAMKAE----- 384
A + L+ +L++ +L+AQ+ A +RQ LQ Q Q ++ E
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
Query: 385 -----------KWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQ 433
+ L + +LE + ESV KE+E L + DSL + +E+L L R ++
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL--LHERQASE 1173
Query: 434 ADPSLDPTST-PVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDA 492
+ + T + E+ +L + +L + +L E + QE++ LE+
Sbjct: 1174 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKML--LENK 1231
Query: 493 NRARHGLE------TQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQ 546
N E RLN S+L + E LQ + +S L + +LE
Sbjct: 1232 NHETVAAEYKKLCGENDRLN-HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1290
Query: 547 KLHE-------ADLELQRKREYIEELEPPTDSSTARRIEELQ-----------HNLQKKD 588
KL E +L + E + +L+ + ++++Q N++ KD
Sbjct: 1291 KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
Query: 589 ADLRAMEERYRRYVDKARMVMQTME 613
R+Y+DK + + E
Sbjct: 1351 ----LFHVEQRQYIDKLNELRRQKE 1371
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 129 bits (325), Expect = 7e-30
Identities = 175/742 (23%), Positives = 332/742 (44%), Gaps = 114/742 (15%)
Query: 12 LLTWLQTFHVPSPCASPQD--------LSSGLAVAYVLNQIDPSWFNEAWLQGISEDPGP 63
L+TW++TF P A+ L G+ + V+ QI+P ++ + ++ D
Sbjct: 18 LVTWVKTF---GPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKVNNDAS- 73
Query: 64 NWKLKVSNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGE--FSDPA--ELGKLLQLVL 119
L++ NL +++R + Y Q+ L + LP+V +IG+ FS+ E+ KLL L+L
Sbjct: 74 ---LRMHNLSILVRQIKFYYQETLQQLIMMS-LPNVLIIGKNPFSEQGTEEVKKLLLLLL 129
Query: 120 GCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYF 179
GCA+ C+KK++ I+RI L+ + V IQE+ FD Q
Sbjct: 130 GCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQE---------NVFDLQWMEVTD 180
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQS---LAQENAGLR----ERMGRPEGEGTPG 232
+S+E E L+ L L+R + E ++ L++E GL G+PG
Sbjct: 181 MSQEDIE-PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 233 LT--------AKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALT 284
+ + +L ++++ +L++E D + ++E E+ LQ N L
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 285 SLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAER 344
S A+ A+ +DE+D LR+ + R +LE+ ++ + RL ++ + +V +L+E N E
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 345 TRQLEDELR--RAGS------------LRAQL-------EAQRRQVQELQGQRQEEAMKA 383
LED+L RA S L+A+L + R++++EL + M
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
Query: 384 EKWLFECRNLEEKYESVTKEKERLLAERDSL-REANE----ELRCAQLQPRGLTQADPSL 438
++ + E +L + E +++ E A + SL E NE L +++ + LT+ L
Sbjct: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL 479
Query: 439 DPTSTPVDNLAAEILPAEL-------------------RETLLRLQLENKRLCRQEA--- 476
T V+ A++IL E +++L Q +K L +++A
Sbjct: 480 RTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLE 539
Query: 477 ----ADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQK-------ALQ 525
RE E + LE N H +T L Q+ A+V+D++K +++
Sbjct: 540 KTIETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 526 EQGGKTEDSILLKRKLE---EHLQKLHEADLELQRKREYIE-ELEPPTDSSTARRIE-EL 580
E K KR+++ EH ++ E EL+ + ++E E E T +I E
Sbjct: 598 ETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK 657
Query: 581 QHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLR---TQLRERD 637
L++++++L + ++ +D + + +E ++ + E LR L+
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS 717
Query: 638 VRIRHLEMDFEKSRSQREQEEK 659
+++ L+++ ++ S++EQ +K
Sbjct: 718 MKMAQLQLENKELESEKEQLKK 739
Score = 70.9 bits (172), Expect = 4e-12
Identities = 106/503 (21%), Positives = 219/503 (43%), Gaps = 57/503 (11%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
+E L + + +L + EK+ + +E +E+ R E L+++
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE-------------LENE 633
Query: 245 LEQLQEENFRLESGREDERLRCAE---LEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
L L++EN L+ + ++ C + LE+E +EL+ N+ L + L +++ L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
+ + QL+ RR + L+ ++ QL+ N ++LE E +
Sbjct: 694 KEN---SQLDEENLELRRNVESLKCASMKMAQLQLEN-------KELESEKEQLKKGLEL 743
Query: 362 LEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEEL 421
L+A ++ + L+ Q ++ ++ N +K + + E + L E +L++ EEL
Sbjct: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
Query: 422 RCAQLQPRGLTQADPSLDPTSTPVDNLAAEI--------LPAELRETLL--------RLQ 465
+ + + L + + SL+ ++ ++ ++ AE+++T L L+
Sbjct: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 466 LENKRLCRQEAADRE---RQEELQR-HLEDANRARHGLETQHRLNQQQLSE-LRAQV--E 518
ENK L ++ +E R +EL++ + E RA ++T L + +SE L+ Q
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 519 DLQKALQ--EQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARR 576
DL+K E+ G ++ +L + + KL E+ LE K+ E++ ++ R
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL--EIKEEKIAALEAR 981
Query: 577 IEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPP--ELHSLRTQLR 634
+EE + Q+ +L+ +++ Y K R + M P +G E S T
Sbjct: 982 LEESTNYNQQLRQELKTVKKNYEAL--KQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
Query: 635 ERDVRIRHLEMDFEKSRSQREQE 657
V+ R +E++ + Q E++
Sbjct: 1040 LLKVKDRLIEVERNNATLQAEKQ 1062
Score = 58.9 bits (141), Expect = 2e-08
Identities = 96/411 (23%), Positives = 171/411 (41%), Gaps = 51/411 (12%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L + + + LQ + L L+RQ + L E+ +L +NA L+ + T + L
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAEL--EREVAELQHRNQALTSLAQEAQALKDEM 297
L+Q L+ EN + RED + L + E EL H Q A E ++L +
Sbjct: 1128 LIQQ--SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ-----ASEYESLISKH 1180
Query: 298 DELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGS 357
L+ + + L + R LE+R ++ QLED
Sbjct: 1181 GTLKSAH--------------------KNLEVEHRDLEDRYNQLLKQKGQLED------- 1213
Query: 358 LRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREA 417
L L+ ++ ++ + A + +K E L Y + KE E L + +L+
Sbjct: 1214 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL 1273
Query: 418 --NEELRCAQLQPR--GLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCR 473
N +L +L+ L + LD TST ++N E+L ++L+ L+ EN+ L
Sbjct: 1274 LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNN-QCELL-SQLKG---NLEEENRHLLD 1328
Query: 474 QEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTED 533
Q + L LE ++ + R +L+ELR Q E L++ + +Q +
Sbjct: 1329 QIQTLMLQNRTL---LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDP 1385
Query: 534 SILLKRK--LEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQH 582
S +R + ++KL ++ ++ R+R+ L PT S ++ +L H
Sbjct: 1386 SPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL-TPTRSDSSEGFLQLPH 1435
Score = 57.0 bits (136), Expect = 6e-08
Identities = 125/581 (21%), Positives = 230/581 (39%), Gaps = 79/581 (13%)
Query: 197 LERQLMLLSEEKQSLAQENAGL-RERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRL 255
L+ Q M EK + E GL +ER+ E T + LL+S+LE +++ +
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS-----TDDRYKLLESKLESTLKKSLEI 970
Query: 256 ESGREDERLRCAE--LEREVAELQHRNQALTSLAQEAQALKDEMDELRQ---SSERAGQL 310
+ +E++ E LE Q Q L ++ + +ALK DE R S +G+
Sbjct: 971 K----EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1026
Query: 311 EATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRA----GSLRAQLEAQR 366
+ EL +++ ++ ++E NA + L+ +L++ +L+AQ+ A +
Sbjct: 1027 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086
Query: 367 RQVQELQGQR-----QEEAMKAE----------------KWLFECRNLEEKYESVTKEKE 405
RQ LQ Q Q ++ E + L + +LE + ESV KE+E
Sbjct: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1146
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTST-PVDNLAAEILPAELRETLLRL 464
L + DSL + +E+L L R ++ + + T + E+ +L + +L
Sbjct: 1147 DLKSLYDSLIKDHEKLEL--LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204
Query: 465 QLENKRLCRQEAADRERQEELQRHLEDANRARHGLE------TQHRLNQQQLSELRAQVE 518
+ +L E + QE++ LE+ N E RLN S+L + E
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKML--LENKNHETVAAEYKKLCGENDRLN-HTYSQLLKETE 1261
Query: 519 DLQKALQEQGGKTEDSILLKRKLEEHLQKLHE-------ADLELQRKREYIEELEPPTDS 571
LQ + +S L + +LE KL E +L + E + +L+ +
Sbjct: 1262 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE 1321
Query: 572 STARRIEELQ-----------HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAA 620
++++Q N++ KD R+Y+DK + + E +
Sbjct: 1322 ENRHLLDQIQTLMLQNRTLLEQNMESKD----LFHVEQRQYIDKLNELRRQKEKLEEKIM 1377
Query: 621 GAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMG----MALQQRA 676
+ R + ++ ++ K RE+++ L ++ + + L +
Sbjct: 1378 DQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQD 1437
Query: 677 GEERAPAHAQSFLAQQRLAT-NSRRGPLGRLASLNLRPTDK 716
++ + + S Q L T S L RL L RP DK
Sbjct: 1438 SQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDK 1478
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 103 bits (256), Expect = 7e-22
Identities = 138/604 (22%), Positives = 259/604 (42%), Gaps = 74/604 (12%)
Query: 121 CAISCEKK--QDHIQRIMTL-----EESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQ 173
C ++ EKK +D I T E+S ++ E M D + L E +
Sbjct: 988 CKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE------EK 1041
Query: 174 SRRYYFLSEEAEEGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTP 231
R+ + EGD +L + +L+ Q+ +E K LA++ L+ + R E E
Sbjct: 1042 QRQELEKTRRKLEGDSTDLSDQIAELQAQI---AELKMQLAKKEEELQAALARVEEEAAQ 1098
Query: 232 -GLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEA 290
+ KK+ L+SQ+ +LQE+ LES R R AE Q R+ L +E
Sbjct: 1099 KNMALKKIRELESQISELQED---LESER---------ASRNKAEKQKRD-----LGEEL 1141
Query: 291 QALKDEMDELRQSS----ERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTR 346
+ALK E+++ S+ E + E + ++ L E E + Q++E H++
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE--EAKTHEAQIQEMRQKHSQAVE 1199
Query: 347 QLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKER 406
+L ++L + ++A LE ++ ++ +G+ E + + + +K E+ +E +
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 407 LLAERDSLR-EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
E + +R E +++ Q++ +T D S+ + L ++L++T LQ
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK-DFSALESQLQDTQELLQ 1318
Query: 466 LENKRLCRQEAADRERQEE---LQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQK 522
EN++ ++ ++E + LE+ A+H LE +Q++ L AQV D++K
Sbjct: 1319 EENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE-------KQIATLHAQVADMKK 1371
Query: 523 ALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQH 582
+++ G E + +KRKL++ L+ L + E + +E+ + + +L H
Sbjct: 1372 KMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDH 1431
Query: 583 ------NLQKKD-------ADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGA------- 622
NL+KK A+ + + +Y D+A + E K A A
Sbjct: 1432 QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ 1491
Query: 623 PPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP 682
EL L Q R + + D KS + E+ ++ L M L++ E +A
Sbjct: 1492 KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT 1551
Query: 683 AHAQ 686
A+
Sbjct: 1552 EDAK 1555
Score = 87.8 bits (216), Expect = 3e-17
Identities = 130/553 (23%), Positives = 240/553 (43%), Gaps = 60/553 (10%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
+ E AE+ ++ ++ +LE+ L E+ LA E L + G E K
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE---------HKRK 1248
Query: 240 LLQSQLEQLQE-----ENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALK 294
+++QL++LQ E R E + +L+ EL+ L + + L ++ AL+
Sbjct: 1249 KVEAQLQELQVKFNEGERVRTELADKVTKLQ-VELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 295 DEM--------DELRQS---SERAGQLEATLTSCRRRLGELRELRRQV-RQLEERNAGHA 342
++ +E RQ S + Q+E S R +L E E + + +Q+ +A A
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367
Query: 343 ERTRQLEDELRRAGSLRAQLEAQRRQVQELQG--QRQEEAMKAEKWLFECRNLEEKYESV 400
+ +++ED + G L E +R+ ++L+G QR EE + A LE+ +
Sbjct: 1368 DMKKKMEDSV---GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD------KLEKTKTRL 1418
Query: 401 TKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPT-STPVDNLAAEILPAELRE 459
+E + LL + D R++ L Q + L + ++ + D AE E +
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKA 1478
Query: 460 TLLRLQLENK-----RLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELR 514
L LE L R R E+L +D ++ H LE R +QQ+ E++
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538
Query: 515 AQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLH-EADLELQRKREYIEELEPPTDSST 573
Q+E+L+ LQ TED+ K +LE +LQ + + + +LQ + E EE +
Sbjct: 1539 TQLEELEDELQ----ATEDA---KLRLEVNLQAMKAQFERDLQGRDEQSEEKK----KQL 1587
Query: 574 ARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQT-MEPKQRPAAGAPPELHSLRTQ 632
R++ E++ L+ + R+M R+ ++ ++ ++ + A +L L+ Q
Sbjct: 1588 VRQVREMEAELE-DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQ- 691
+++ + E+ +Q ++ EK L S M ++ A ERA AQ +
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
Query: 692 -QRLATNSRRGPL 703
+A +S +G L
Sbjct: 1707 ADEIANSSGKGAL 1719
Score = 79.3 bits (194), Expect = 1e-14
Identities = 113/489 (23%), Positives = 214/489 (43%), Gaps = 59/489 (12%)
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL-----QS 243
EL++ C DLE ++ E Q L E +++ + E + +A++ L L ++
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEA 971
Query: 244 QLEQLQEENFRLES-----GREDERL--RCAELEREVAELQHRNQALTSLAQEAQALKDE 296
+L++L+EE LE +E + L R AE + E + ++++L L + +A+ +
Sbjct: 972 KLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITD 1031
Query: 297 MDE-LRQSSERAGQLEATLTSCRRRL-GELRELRRQVRQLEERNAGHAERTRQLEDELRR 354
++E LR+ ++ +LE T RR+L G+ +L Q+ +L+ + A
Sbjct: 1032 LEERLRREEKQRQELEKT----RRKLEGDSTDLSDQIAELQAQIA--------------- 1072
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
L+ QL + ++Q + +EEA + L + R LE + +++ +E L +ER S
Sbjct: 1073 --ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ---ISELQEDLESERASR 1127
Query: 415 REANEELRCAQLQPRGL-TQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCR 473
+A ++ R + L T+ + +LD T+ + + + + L + +
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQI 1187
Query: 474 QEAADRERQ--EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKT 531
QE + Q EEL LE R + LE + + + EL +V+ L LQ +G
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL---LQGKG--- 1241
Query: 532 EDSILLKRKLEEHLQKLHEADLELQRKR----EYIEELEPPTDSSTARRIEELQHNLQKK 587
DS ++K+E LQ+L E +R R + + +L+ D+ T + + K
Sbjct: 1242 -DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG-LLSQSDSKSSKL 1299
Query: 588 DADLRAMEERYRRYVDKARMVMQTMEPK---QRPAAGAPPELHSLRTQLRERDVRIRHLE 644
D A+E + + D ++ + K E +S R QL E + +LE
Sbjct: 1300 TKDFSALESQLQ---DTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 645 MDFEKSRSQ 653
+Q
Sbjct: 1357 KQIATLHAQ 1365
Score = 70.5 bits (171), Expect = 5e-12
Identities = 104/469 (22%), Positives = 194/469 (41%), Gaps = 108/469 (23%)
Query: 236 KKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
++++ + +L +++E+ E+ + ++L E +LQ + QA T L EA+
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE---- 900
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRA 355
+L A LT+ ++ L E+ LE R +E+E R
Sbjct: 901 -------------ELRARLTAKKQELEEI------CHDLEAR----------VEEEEERC 931
Query: 356 GSLRAQLEAQRRQVQELQGQRQEE-------------------AMKAEKWLFECRN---- 392
L+A+ + ++ +QEL+ Q +EE ++ E+ + E +N
Sbjct: 932 QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLA 991
Query: 393 -----LEEKYESVT------KEKERLLAERDSLREA-----NEELRCAQLQPRGLTQADP 436
LE++ T +EK + LA+ + EA E LR + Q + L +
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 437 SLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQE------------- 483
L+ ST + + AE L A++ E L++QL K Q A R +E
Sbjct: 1052 KLEGDSTDLSDQIAE-LQAQIAE--LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 484 ------ELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL---QKALQEQGGKTEDS 534
ELQ LE +R+ E Q R ++L L+ ++ED A QE K E
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168
Query: 535 ILLKRKLEEHLQKLHEADLELQRKR--EYIEELEPPTDSSTARRIEELQHNLQKKDADLR 592
+ + +K E K HEA ++ R++ + +EEL + + + ++ NL+K +
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL-----AEQLEQTKRVKANLEKAK---Q 1220
Query: 593 AMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIR 641
+E ++ ++++Q + +L L+ + E + R+R
Sbjct: 1221 TLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGE-RVR 1268
Score = 63.2 bits (152), Expect = 8e-10
Identities = 99/542 (18%), Positives = 218/542 (40%), Gaps = 45/542 (8%)
Query: 140 ESVQHVVMEAIQELMTK-DTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLE 198
E V+ + + + +L + D L ++ ++ + L + ++ EL Q +
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQ---EEN 1321
Query: 199 RQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQL----EQLQEENFR 254
RQ + LS + + + E RE++ E E K++ L +Q+ +++++
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQL--EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 255 LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATL 314
LE+ E +R +LE + + A L + L+ E+D+L + Q L
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439
Query: 315 TSCRRRLGEL--RELRRQVRQLEERNAGHAER----------TRQLEDELRRAGSLRAQL 362
+++ +L E + EER+ AE R LE+ + + L
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499
Query: 363 EAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR 422
+ R ++++L + + + R LE++ E + + E L E + +A L
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 423 CAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQ 482
LQ Q + L + +++ ++RE L+ E K+ AA ++ +
Sbjct: 1560 -VNLQAMK-AQFERDLQGRDEQSEEKKKQLV-RQVREMEAELEDERKQRSMAVAARKKLE 1616
Query: 483 ---EELQRHLEDANRAR-------HGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTE 532
++L+ H++ AN+ R L+ Q + ++L + RA E++ +E K +
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK 1676
Query: 533 DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTA----------RRIEELQH 582
+L+E L A + Q++R+ + + + A RI +L+
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEE 1736
Query: 583 NLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 642
L+++ + + +R ++ + + + ++ A L Q +E V+++
Sbjct: 1737 ELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQE 1796
Query: 643 LE 644
+E
Sbjct: 1797 ME 1798
Score = 58.2 bits (139), Expect = 3e-08
Identities = 80/361 (22%), Positives = 150/361 (41%), Gaps = 77/361 (21%)
Query: 319 RRLGELRELRRQVRQLEERNAGHAE----RTRQL--EDELRRAGSLRAQLEAQRRQVQE- 371
R +++ L + RQ EE A E R +QL E+ L +L++QL A++ Q+QE
Sbjct: 829 RLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ 888
Query: 372 --------LQGQRQEEAMKAEKWLFE--CRNLEEKYESVTKEKERLLAERDSLREANEEL 421
+ + + A+K E C +LE + E + + L AE+ +++ +EL
Sbjct: 889 LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQEL 948
Query: 422 RCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRER 481
QL+ + L+ +T E +L E + L+ +N +L +++ +R
Sbjct: 949 E-EQLEEEESARQKLQLEKVTT-------EAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 482 QEELQRHL---EDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLK 538
E +L E+ +++ L+ +H A + DL++ L+ + + ++ +
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHE----------AMITDLEERLRREEKQRQELEKTR 1050
Query: 539 RKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERY 598
RKLE L + ELQ + I EL+ L KK+ +L+A R
Sbjct: 1051 RKLEGDSTDLSDQIAELQAQ------------------IAELKMQLAKKEEELQAALARV 1092
Query: 599 RRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEE 658
+ M ++ ++RE + +I L+ D E R+ R + E
Sbjct: 1093 EEEAAQKNMALK---------------------KIRELESQISELQEDLESERASRNKAE 1131
Query: 659 K 659
K
Sbjct: 1132 K 1132
Score = 52.0 bits (123), Expect = 2e-06
Identities = 73/315 (23%), Positives = 133/315 (42%), Gaps = 39/315 (12%)
Query: 171 DSQSRRYYFLSEEAEEGDELQQ---RCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
D+++ R L++ E +L+ + L+ +L K+ QE L + + G
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG 1715
Query: 228 EGTPGLTAKKLLLLQSQLEQLQEENFRLESGRE--DERLRCAELE---------REVAEL 276
+G L K+ L ++++ QL+EE + E ++RL+ A L+ E +
Sbjct: 1716 KGALALEEKRRL--EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHA 1773
Query: 277 QHRNQALTSLAQEAQALKDEMDELR---QSSERAG--QLEATLTSCRRRL-GELRELRRQ 330
Q A L ++ + LK ++ E+ +S +A LEA + +L E +E +
Sbjct: 1774 QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAA 1833
Query: 331 VRQLEERNAGHAERTRQLEDELRRAGSLRAQ-------LEAQRRQVQELQGQRQEEAMKA 383
+Q+ + Q++DE R A + Q L+ +RQ++E +EEA +A
Sbjct: 1834 CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEE----AEEEAQRA 1889
Query: 384 EKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTST 443
R L+ + E T+ + + E SL+ + PR + + D +
Sbjct: 1890 NA---SRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAG-DGSDE 1945
Query: 444 PVDNLA--AEILPAE 456
VD A AE PAE
Sbjct: 1946 EVDGKADGAEAKPAE 1960
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 103 bits (256), Expect = 7e-22
Identities = 144/567 (25%), Positives = 243/567 (42%), Gaps = 81/567 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQL--------------MLLSEEKQSLAQENAGLRERMGRP 225
L EA+ G EL+++ L L++ L M+ E L Q A + +
Sbjct: 669 LRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRET 728
Query: 226 EGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALT- 284
+ E +++L L+ +QL+E ++ G E +L+R AE Q +AL
Sbjct: 729 QEENDE--FRRRILGLE---QQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNA 783
Query: 285 ------SLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRE-LRRQVRQLEER 337
SLA +AL+ ++E ++ R GQ + TL G+ RE LRR +LEE+
Sbjct: 784 SQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQ 843
Query: 338 NAGHAERTRQLEDELRRAGS--------LRAQLE----AQRRQVQELQGQRQEEAMKAEK 385
+L EL + G L+AQLE RR+V + Q Q ++ A +AEK
Sbjct: 844 KRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEK 903
Query: 386 WLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPV 445
L+++ + + + + AERD+ R ++EL +LQ GL Q +
Sbjct: 904 TSGGLSRLQDEIQRLRQALQASQAERDTAR-LDKELLAQRLQ--GLEQ---EAENKKRSQ 957
Query: 446 DNLAAEILPAELRETLLRLQLENKRLCRQEAADR-----ERQEELQRHLEDANRARHGLE 500
D+ A ++ E + + L +L+ ++ + DR ++ ++L+ L AR LE
Sbjct: 958 DDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLE 1017
Query: 501 TQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKRE 560
L Q +DL+ L G + S L + LE Q L E +R++
Sbjct: 1018 CDK-------ISLERQNKDLKTRLASSEGFQKPSASLSQ-LESQNQLLQERLQAEEREKT 1069
Query: 561 YIEELEPPTDSSTARRIEEL--------QH-NLQKKDADLRAMEERYRRYVDKARMVMQT 611
++ T+ R+++EL QH N QK LR + +R VD+A ++
Sbjct: 1070 VLQS----TNRKLERKVKELSIQIEDERQHVNDQKDQLSLRV--KALKRQVDEAEEEIER 1123
Query: 612 MEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMA 671
++ ++ A E H + QL+ RI+ LE D + S+ E SA N G++
Sbjct: 1124 LDGLRKKAQREVEEQHEVNEQLQ---ARIKSLEKDSWRKASRSAAE-----SALKNEGLS 1175
Query: 672 LQQRAGEERAPAHAQSFLAQQRLATNS 698
+ P+ S L + L T+S
Sbjct: 1176 SDEEFDSVYDPSSIASLLTESNLQTSS 1202
Score = 88.6 bits (218), Expect = 2e-17
Identities = 164/602 (27%), Positives = 259/602 (43%), Gaps = 91/602 (15%)
Query: 109 AELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYG 168
+ L +LL+ G A K+ +++R++ E ++H + + EL K PE
Sbjct: 404 SRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNK-LKHVQGPEPAK 462
Query: 169 NF---DSQSRRYYFLSEEAEEGDELQQRCLDL-ERQLMLLS----EEKQSLAQENAGLR- 219
D R L EE EG + + L L ER+L L EE S QE +R
Sbjct: 463 EVLLKDLLETRE--LLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQ 520
Query: 220 ------ERMGRPEGEGTPG---LTAKKLLL------LQSQLEQLQEENFRLESGREDERL 264
E++ R + T L A++ + LQ +LE+ EE +S + +
Sbjct: 521 QYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKE 580
Query: 265 RCAELEREVAELQHRNQALTS-LAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGE 323
++E+ +L+ + + L ++ + L+ E+++ R S+ Q+E R E
Sbjct: 581 DLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEE 640
Query: 324 LRELRRQVRQLEERNAGHAERTRQLEDEL---RRAGSLRAQLEAQRRQVQE-LQGQRQ-- 377
L+EL+ + RQ +E H R R+LE +L R +LE Q Q+Q+ LQ RQ
Sbjct: 641 LKELQAE-RQSQEVAGRH--RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDC 697
Query: 378 EEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPS 437
EEA KA K + E T +R A +LRE EE + + GL Q
Sbjct: 698 EEASKA-KMVAEAE--------ATVLGQRRAAVETTLRETQEENDEFRRRILGLEQ---Q 745
Query: 438 LDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARH 497
L T VD E + A LR+ L RL+ E ++L +EA + ++EE A+
Sbjct: 746 LKETRGLVDG--GEAVEARLRDKLQRLEAEKQQL--EEALNASQEEE-----GSLAAAKR 796
Query: 498 GLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
LE + Q+ L+ L + + L +AL+E+G + E K +LEE + L L +
Sbjct: 797 ALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNK 856
Query: 558 KREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPKQ 616
+ E I E DS A LQ+ A L +E+ RR V D R +
Sbjct: 857 ELEKIGE-----DSKQA---------LQQLQAQLEDYKEKARREVADAQRQAKDWASEAE 902
Query: 617 RPAAG---APPELHSLRTQLR----ERDV----------RIRHLEMDFE-KSRSQREQEE 658
+ + G E+ LR L+ ERD R++ LE + E K RSQ ++
Sbjct: 903 KTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRAR 962
Query: 659 KL 660
+L
Sbjct: 963 QL 964
Score = 75.1 bits (183), Expect = 2e-13
Identities = 140/589 (23%), Positives = 238/589 (40%), Gaps = 111/589 (18%)
Query: 153 LMTKDTPDSLSPETY----GNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEK 208
L K TPD L + G+ D Y + E E R R++ L+ E+
Sbjct: 290 LQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVR-----RKVSLVLEKM 344
Query: 209 QSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ-------LQEENFRLESGRED 261
Q L ++G + + +GE T +K+ LQ +L++ L+ LE E+
Sbjct: 345 QPLVMVSSGSTKAVAG-QGELT-----RKVEELQRKLDEEVKKRQKLEPSQVGLERQLEE 398
Query: 262 ERLRCAEL----EREVAELQHRNQALTSLAQEAQALKDEMDELRQSSE-RAGQLEATLTS 316
+ C+ L ER E Q N+ L Q + L D+ ++LR E + +L+ L
Sbjct: 399 KTEECSRLQELLERRKGEAQQSNKEL----QNMKRLLDQGEDLRHGLETQVMELQNKLKH 454
Query: 317 CR----------RRLGELRELRRQV---------------------------------RQ 333
+ + L E REL +V ++
Sbjct: 455 VQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514
Query: 334 LEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQ----VQELQGQRQEEAMKAEKWLFE 389
+E + T QL ++ A A LEA+R++ V+ LQ + +E + + W
Sbjct: 515 VEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQ-- 572
Query: 390 CRNLEEKYESVTKEKERLLAERDSLREANEEL-RCAQLQPRGLTQADPSLDPTSTPVDNL 448
++ E + K+ LL R E EEL ++ R L QA S T V+ L
Sbjct: 573 -SMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDT-RQVEVL 630
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLE----DANRARHGLETQHR 504
E+L +E L LQ E + QE A R R EL++ L +A+R R LE Q+
Sbjct: 631 KKELL--RTQEELKELQAERQ---SQEVAGRHRDRELEKQLAVLRVEADRGRE-LEEQNL 684
Query: 505 LNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK--LEEHLQKLHEADLELQRK---- 558
Q+ L +LR E+ KA + + E ++L +R+ +E L++ E + E +R+
Sbjct: 685 QLQKTLQQLRQDCEEASKA--KMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL 742
Query: 559 REYIEELEPPTDSSTA------RRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTM 612
+ ++E D A +++ L+ Q+ + L A +E R + +
Sbjct: 743 EQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARL 802
Query: 613 EPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLL 661
E QR A E +L L E + L + +++ E++++LL
Sbjct: 803 EEAQRGLARLGQEQQTLNRALEEEGKQREVL----RRGKAELEEQKRLL 847
Score = 65.5 bits (158), Expect = 2e-10
Identities = 88/426 (20%), Positives = 175/426 (41%), Gaps = 43/426 (10%)
Query: 280 NQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGEL-RELRRQVRQLEERN 338
+++ TS+ ++ + ++M L S + + A R++ EL R+L +V++ ++
Sbjct: 327 SESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLE 386
Query: 339 AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYE 398
RQLE++ L+ LE ++ + Q Q +E ++ L + +L E
Sbjct: 387 PSQVGLERQLEEKTEECSRLQELLERRKGEAQ----QSNKELQNMKRLLDQGEDLRHGLE 442
Query: 399 SVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELR 458
+ E + L A E L L+ R L L+ + ++ E
Sbjct: 443 TQVMELQNKLKHVQGPEPAKEVLLKDLLETREL------LEEVLEGKQRVEEQLRLRERE 496
Query: 459 ETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVE 518
T L+ L+ + R + + RQ+ QR E R+ H + + + ++ A V
Sbjct: 497 LTALKGALKEEVASRDQEVEHVRQQ-YQRDTEQLRRSMQDATQDHAVLEAERQKMSALVR 555
Query: 519 DLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIE 578
LQ+ L+E +T + +K +E L+ + L+L+ ++E +EE +IE
Sbjct: 556 GLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEE-------ELGEKIE 608
Query: 579 ELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDV 638
LQ L++ RA R+ + +++T E EL L+ + + ++V
Sbjct: 609 VLQRELEQ----ARASAGDTRQVEVLKKELLRTQE-----------ELKELQAERQSQEV 653
Query: 639 RIRHLEMDFEK---------SRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFL 689
RH + + EK R + +E+ L + + A + + A A++ +
Sbjct: 654 AGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATV 713
Query: 690 AQQRLA 695
QR A
Sbjct: 714 LGQRRA 719
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 102 bits (255), Expect = 9e-22
Identities = 129/501 (25%), Positives = 228/501 (45%), Gaps = 70/501 (13%)
Query: 204 LSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDER 263
L E K L Q+ GL ++G E +++++LQ QL++ +E+ G E+
Sbjct: 1748 LQELKDQLEQQLQGLHRKVG--ETSLLLSQREQEIVVLQQQLQEAREQ------GELKEQ 1799
Query: 264 LRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERA-GQLEATLTSCRRRLG 322
++L+ L R+Q L +L QE Q + + + +++ ++ G LE + + R G
Sbjct: 1800 SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHG 1859
Query: 323 ELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMK 382
EL++ + Q R+LEE A R + LE+ L G LRA+ Q + + LQ Q E+A +
Sbjct: 1860 ELQDHKEQARRLEEELAVEGRRVQALEEVL---GDLRAESREQEKALLALQQQCAEQAQE 1916
Query: 383 AEKWLFECRNLEEKY---ESVTKEK----ERLLAERDSLREANEELRC-AQLQPRGLTQA 434
E E R L++ + ++V KE+ E L AE S R E R A+ L +A
Sbjct: 1917 HE---VETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 435 DPSLDPTSTPVDNLAA-----EILPAELRETLLRLQLENKRLCRQEAADRERQEELQ--- 486
+L + A E A L+ +L Q +++L E A R ++ E+Q
Sbjct: 1974 HAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQL---EEALRIQEGEIQDQD 2030
Query: 487 -RHLEDANRARHGL-----ETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK 540
R+ ED + + L E +H+ ++QL E + L + +QE + + ++ +R+
Sbjct: 2031 LRYQEDVQQLQQALAQRDEELRHQQEREQLLE-----KSLAQRVQENMIQEKQNLGQERE 2085
Query: 541 LEEHLQKLHEADLELQ-----RKREYIE--------ELEPPTDSSTARRIEE-------- 579
EE ++ LH++ ELQ +++E +E LE S +EE
Sbjct: 2086 -EEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144
Query: 580 ---LQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRER 636
LQ L++ A LR E R + +KA+ + ++ + + L+ + ER
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLER 2204
Query: 637 DVRIRHLEMDFEKSRSQREQE 657
D + L+ + E +R E+E
Sbjct: 2205 DSEQQRLQDELELTRRALEKE 2225
Score = 92.8 bits (229), Expect = 1e-18
Identities = 157/627 (25%), Positives = 264/627 (42%), Gaps = 118/627 (18%)
Query: 127 KKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEE 186
KKQ + LE H ME Q+L+ E G ++Q L+ + EE
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIK---------ELEGQRETQRVALTHLTLDLEE 1599
Query: 187 -GDELQQRCL---DLERQLMLLSEEKQSLAQENAGLRER---MGRPEGEGTPGLTAK--K 237
ELQ + DLE +L+ E Q QE RE+ + R + T L + +
Sbjct: 1600 RSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 238 LLLLQSQLEQLQEENFR----LESGREDERLRCAELEREV-------------------- 273
L+L + +++ L+++ R LE E +L E RE+
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 274 --AELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGEL------R 325
L+H L +E + ++ + EL++ + QLE L R++GE R
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKD---QLEQQLQGLHRKVGETSLLLSQR 1776
Query: 326 E-----LRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ-LEAQRRQVQELQGQRQEE 379
E L++Q+++ E+ + + DE +RA + R Q LEA +++ Q+ QGQ +
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836
Query: 380 AMKAEKWLFECR----NLEEKYESVT--KEKERLLAER--------DSLREANEELRCAQ 425
KA+ L+E++ + KE+ R L E +L E +LR
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896
Query: 426 ---------LQPRGLTQADPSLDPTSTPVDN-LAAEILPAELRETLLRLQLENKRLCRQE 475
LQ + QA T D+ L A+ + E + L L+ E++ QE
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQE 1956
Query: 476 AADRERQEELQRHLEDANRARHGLETQHRLNQQQLSE---------------LRAQVEDL 520
A R R E LQ L A+ A G E QH L Q +LS +A L
Sbjct: 1957 EAARARAEALQEALGKAHAALQGKE-QHLLEQAELSRSLEASTATLQASLDACQAHSRQL 2015
Query: 521 QKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEE- 579
++AL+ Q G+ +D L + +E +Q+L +A + + + +E E + S A+R++E
Sbjct: 2016 EEALRIQEGEIQDQDL---RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072
Query: 580 ---LQHNL--QKKDADLRAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPELHSLR 630
+ NL ++++ ++R + + R K + +++ E +QR A P HS +
Sbjct: 2073 MIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALP--HSHK 2130
Query: 631 TQLRERDVRIRHLEMDFEKSRSQREQE 657
T E + L++D + R QRE E
Sbjct: 2131 TSPMEE----QSLKLDSLEPRLQRELE 2153
Score = 84.7 bits (208), Expect = 3e-16
Identities = 125/525 (23%), Positives = 227/525 (43%), Gaps = 76/525 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPE------GEGTPGLTAKKLLLL 241
++L Q E L +EK++L +E A L R+ E E GL++ K LL
Sbjct: 711 EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELL- 769
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
+S L + Q++N +E + +LE ++Q QA + E + LK E+D R
Sbjct: 770 ESSLFEAQQQNSVIEVTK-------GQLE---VQIQTVTQAKEVIQGEVRCLKLELDTER 819
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGS---- 357
+E+ A R+L + + + LE++ A H + QL ++ + S
Sbjct: 820 SQAEQERDAAA------RQLAQAEQEGKTA--LEQQKAAHEKEVNQLREKWEKERSWHQQ 871
Query: 358 ---------------LRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTK 402
L +L+ Q+ +++ +Q QR+EE +AE L + + LE + E V+
Sbjct: 872 ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQ-LETEKERVSL 930
Query: 403 EKERLLAERDSLREANEEL-RCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPA--ELRE 459
E LL + L +A+++L R Q + + T + E+ A + R+
Sbjct: 931 -LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRD 989
Query: 460 TLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
L LQ E+ L + + +LQ+ +ED + RL +Q++ E + ++
Sbjct: 990 DLAALQEESSSLLQDKM-------DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQE 1042
Query: 520 ---LQKALQEQGGKTEDSILLKRKLEEHLQKLHEAD----LELQRKREYIEELEPPTDSS 572
+QK L+ + S++ K E+ L L EAD EL R+ ++E +
Sbjct: 1043 YNRIQKELEREKASLTLSLMEK---EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKEL 1099
Query: 573 TARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
+A ++E L+ +++K+AD A E + ++ + + Q Q A+ E + + Q
Sbjct: 1100 SA-QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQ-----QLRASLWAQEAKAAQLQ 1153
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAG 677
LR R + + E+ + Q + L S + ALQQ G
Sbjct: 1154 LRLRSTESQLEALAAEQQPGNQAQAQAQLASLY----SALQQALG 1194
Score = 83.6 bits (205), Expect = 6e-16
Identities = 127/559 (22%), Positives = 227/559 (40%), Gaps = 54/559 (9%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
E+G+ + L+ L LL++ +E LR ++ E + A +LL L +
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 245 LEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSS 304
++ QE + + E +E E+ R LE +Q R Q LT ++ + L+ + + R
Sbjct: 1467 -KRNQEVDLQQEQIQELEKCRSV-LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVL 1524
Query: 305 E-RAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLE 363
E + +LE + G++++L++Q+ LE E ++E + + L Q E
Sbjct: 1525 EHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRE 1584
Query: 364 AQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRC 423
QR + L +E + + + + +LE + +E + E S RE EEL
Sbjct: 1585 TQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEEL-- 1642
Query: 424 AQLQPRGLTQ----ADPSLDPTSTPVDNL------AAEILPAELRETLLRLQLENKRLCR 473
Q Q LTQ D L + L +IL +L + L L+ + L
Sbjct: 1643 -QRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTT 1701
Query: 474 QEAADRERQEE------LQR-HLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
Q +ER EE QR LE E + Q+ + EL+ + L++ LQ
Sbjct: 1702 QRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQG 1761
Query: 527 QGGKTEDSILLKRKLEEHL----QKLHEADLELQRKREYIEELEPPTDSSTARRIEELQH 582
K ++ LL + E+ + Q+L EA + + K + ++ + A+R +EL+
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELE- 1820
Query: 583 NLQKKDADLRAMEERYRRYVD-------------------------KARMVMQTMEPKQR 617
LQ++ + EER + D +AR + + + + R
Sbjct: 1821 ALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGR 1880
Query: 618 PAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAG 677
L LR + RE++ + L+ + + E E + L +W L++R
Sbjct: 1881 RVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQ 1940
Query: 678 E-ERAPAHAQSFLAQQRLA 695
E E A +QS Q+ A
Sbjct: 1941 ELEALRAESQSSRHQEEAA 1959
Score = 80.1 bits (196), Expect = 7e-15
Identities = 115/521 (22%), Positives = 219/521 (42%), Gaps = 82/521 (15%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L+ + +L+Q+ + + LL ++ +E LR+R+ + GE A + +
Sbjct: 395 LTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDT--LAGQTV 452
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
LQ +++ L +E L+ RE+ R + LE+E L+ N L AQ K+E E
Sbjct: 453 DLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQE 512
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAG-HAERTRQLEDELRRAGSL 358
EL R+ +L+E G A+++ L + + +L
Sbjct: 513 -----------------------ELHLAVRERERLQEMLMGLEAKQSESLSELI----TL 545
Query: 359 RAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREAN 418
R LE+ + EL Q Q E A L +S+ + L + ++L+
Sbjct: 546 REALESSHLE-GELLRQEQTEVTAA---------LARAEQSIAE----LSSSENTLKTEV 591
Query: 419 EELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAAD 478
+LR A ++ L +A +LD L + LL+L+ EN+ +C + A
Sbjct: 592 ADLRAAAVKLSALNEA-LALDKVG--------------LNQQLLQLEEENQSVCSRMEAA 636
Query: 479 RERQEELQRHLEDANRARHG-------LETQHRLNQQQLSELRAQVEDLQKALQEQGGKT 531
+ + LQ L +A + R LE Q + ++ +EL+A + D+Q+ +E K
Sbjct: 637 EQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKL 696
Query: 532 EDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADL 591
+S + L++LH+ E +R+ E + + + R L+ LQ + D
Sbjct: 697 SESRHQQEAATTQLEQLHQ---EAKRQEEVLARAVQEKE-ALVREKAALEVRLQAVERDR 752
Query: 592 RAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLR---------ERDVRIRH 642
+ + E+ + ++ ++ Q+ + L Q++ + +VR
Sbjct: 753 QDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 643 LEMDFEKSRSQREQE--EKLLISAWYNMGMAL-QQRAGEER 680
LE+D E+S++++E++ + L A AL QQ+A E+
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK 853
Score = 73.2 bits (178), Expect = 8e-13
Identities = 129/574 (22%), Positives = 233/574 (40%), Gaps = 87/574 (15%)
Query: 173 QSRRYYFLSEEAEEGDELQQRCLDLERQLM--------LLSEEKQSLAQENAGLRERMGR 224
+ R + E A+ + L++ ++LE +L + ++ ++ Q + L +
Sbjct: 863 EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLE 922
Query: 225 PEGEGTPGL-----TAKKLLLLQSQLEQLQEENFRLESGREDE-------RLRCAELERE 272
E E L T K+L QLE+L+++ +++ +E E +L+ A+ E +
Sbjct: 923 TEKERVSLLETLLQTQKELADASQQLERLRQD-MKVQKLKEQETTGILQTQLQEAQRELK 981
Query: 273 VAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCR-------RRLGELR 325
A QHR+ + + L+D+MD +Q + QL A S R +L E +
Sbjct: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
Query: 326 ELRRQVRQLEERNAGHAERTRQLEDE---LRRAGSLRAQ-LEAQRRQVQELQGQRQEEAM 381
E R ++LE A + E L+ A S+R Q L A R+ +QE QG+++E +
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE--L 1099
Query: 382 KAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCA-QLQPRGLTQADPSLDP 440
A+ L + ++EK ++ +LL E ++ ++LR + Q Q L
Sbjct: 1100 SAQMELLR-QEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158
Query: 441 TSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLE---------- 490
T + ++ LAAE P + +L L + + E + EL +
Sbjct: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEP 1218
Query: 491 DANRAR---------------------HGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
D N AR H L QQ LR QV+ L++ L +
Sbjct: 1219 DQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEA 1278
Query: 530 KTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK--K 587
+ + L+ L + E + + K+ +E S + E +LQ +
Sbjct: 1279 EKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLE--------SELMELHETMASLQSRLR 1330
Query: 588 DADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVR-------I 640
A+L+ ME + R + +A T + + AA + + E D+R +
Sbjct: 1331 RAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKL 1390
Query: 641 RHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQ 674
++ E++ E+ R+Q QE+ L A G ALQ+
Sbjct: 1391 KNEEVESERERAQALQEQGELKVA---QGKALQE 1421
Score = 31.2 bits (69), Expect = 3.5
Identities = 45/188 (23%), Positives = 82/188 (43%), Gaps = 41/188 (21%)
Query: 438 LDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARH 497
++ S ++N+ + L L E +L LQ Q+ A E Q R L+++ A+
Sbjct: 1 METRSPGLNNMKPQSLQLVLEEQVLALQ--------QQMA--ENQAASWRKLKNSQEAQQ 50
Query: 498 GLETQHRLNQQQLSELRAQVEDLQKALQEQGG-------KTEDSIL--LKRKLEEHLQK- 547
T R Q ++ + R+ ++L+K L+ GG E+ L L +LEE Q+
Sbjct: 51 RQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRC 110
Query: 548 -------------LHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAM 594
+ +AD+ + RE +E+L D S AR L +K++ +
Sbjct: 111 ESLAEVNTQLRLHMEKADVVNKALREDVEKL--TVDWSRAR------DELMRKESQWQME 162
Query: 595 EERYRRYV 602
+E ++ Y+
Sbjct: 163 QEFFKGYL 170
Score = 31.2 bits (69), Expect = 3.5
Identities = 32/123 (26%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENA-----GLRERMGRPEGEGTPGLTAKKLLLLQS 243
+L+ +ER+ L E AQ + + +G G AK + LQ
Sbjct: 2295 QLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQK 2354
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHR-NQALTSLAQ--EAQALKDEMDEL 300
++ LQ + ++D R A+ RE+A L H + +L ++AQ EA L+ E L
Sbjct: 2355 EVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRL 2414
Query: 301 RQS 303
+S
Sbjct: 2415 DES 2417
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 532 EDSILLKRKLEEHLQKLHE-----------ADLEL----------QRKREYIEE----LE 566
E ++ + E+ L+K + A+ EL +++R+ +EE L+
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 567 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 626
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1741 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 627 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/579 (27%), Positives = 248/579 (42%), Gaps = 90/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1590
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1591 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1640
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVE--DLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ G Q +Q+L LRA+ E + Q+ L E E+ L+R+ QK
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELARLQREAAAATQKRQ 1751
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1752 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 610 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 662
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 663 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 698
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1868 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/611 (22%), Positives = 261/611 (42%), Gaps = 75/611 (12%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2100
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVA----ELQHRNQALTSLAQEAQALKDEMDE 299
Q + E + + E + A++E+E+ +L+ + L +E Q LK E E
Sbjct: 2161 QAADAEMEKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQV----RQLEERNAGHAERTRQLEDE-LRR 354
++ + Q+E L S R ++ EL +L+ ++ R L R+ + +R Q E E +++
Sbjct: 2219 ---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
A+L ++ L+ Q EE + ++ L E + L+EK ++V +E RL AE + L
Sbjct: 2276 VAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE-KMLKEKMQAV-QEATRLKAEAELL 2332
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
++ E AQ Q R L + + A+ L E + L+ E +R
Sbjct: 2333 QQQKE---LAQEQARRLQEDKEQM-----------AQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
A E L+ + + +RA+ E + ++Q E+ ++ + A QE+ +
Sbjct: 2379 SA----EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYI-----------EELEPPTDSSTARRIEELQHN 583
+ +++ + ++L EA EL+R++E + EE++ + + LQ +
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 584 -LQKKDADL---RAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPE-------LHS 628
L +KD+ L R +E+ + + D+ Q E +QR E +
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2554
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP-AHAQS 687
R + E + +R + + ++ QR Q+E+LL + LQ + RA AH++
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Query: 688 FLAQQRLATNS 698
A Q AT +
Sbjct: 2615 VTASQVAATKT 2625
Score = 88.2 bits (217), Expect = 2e-17
Identities = 144/554 (25%), Positives = 227/554 (40%), Gaps = 78/554 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1595
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1656 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1835 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDSILLKRKLEEHLQKLH-----------EADLELQ 556
+ E AQ+ + L+ Q G ED++ +R++EE + L E +LEL
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 557 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 615
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1950 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 616 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 668 MGMALQQRAGEERA 681
LQQ +E++
Sbjct: 2061 KEQELQQTLQQEQS 2074
Score = 88.2 bits (217), Expect = 2e-17
Identities = 134/541 (24%), Positives = 228/541 (42%), Gaps = 73/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1832
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1833 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1889
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2010 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE----QGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
+ Q L +LR + E ++A +E + ++ +R++EE + A+ + Q
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 558 KRE---YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 614
+ + E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2180
Query: 615 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2181 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 668 M 668
M
Sbjct: 2237 M 2237
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/542 (21%), Positives = 225/542 (41%), Gaps = 40/542 (7%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1072 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1126
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1127 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 522 KALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRI--EE 579
AL++Q E K + E ++L + + + E + E D+ +R EE
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQ-----RMQEEVVRREEAAVDAQQQKRSIQEE 1421
Query: 580 LQHNLQKKDADLRA------MEERYR-RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
LQ Q +A+++A ER R R ++ R+V +E +R GA EL +LR +
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1481
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
E + + R + + E+ R Q + E + A + ++ A R A L +
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 693 RL 694
RL
Sbjct: 1542 RL 1543
Score = 80.1 bits (196), Expect = 7e-15
Identities = 142/633 (22%), Positives = 250/633 (39%), Gaps = 67/633 (10%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1525
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1578
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1694
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 506 NQQQLSELRA--QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE 563
Q+QL+E A Q + ++ L E+ ++ LK + E L+ E + E +R R E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---EKEAENERLRRLAE 1871
Query: 564 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 623
+ ++ RR+EE Q K D + R + R + R +E R
Sbjct: 1872 D-----EAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQRRQVE 1924
Query: 624 PELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMGMALQQRAGEE 679
E+ +L+ + LE++ + RS E +E+ + A +A ++
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 680 RAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
A Q LA + A R+ L + L +
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/467 (24%), Positives = 195/467 (41%), Gaps = 62/467 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2268
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2324
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2325 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2372
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2433 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 527 QGGKTE-DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQH 582
Q + E + L +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596
Query: 583 NLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
LQ + RA EE V + + + PAA A PE
Sbjct: 2597 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/469 (21%), Positives = 180/469 (38%), Gaps = 95/469 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 967 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1023
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1024 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1202
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1203 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 529 GKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ ++
Sbjct: 1263 EKVEE---CQRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQEY 1316
Query: 589 ADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLE 644
DLR + +Y+ ++ ME ++R A Q E R+ +E
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAEVE 1366
Query: 645 MDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 693
EK R E + A LQQR EE + AQQ+
Sbjct: 1367 AALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/479 (21%), Positives = 180/479 (37%), Gaps = 58/479 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 361 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 406
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 407 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 458
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 519 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 576
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 577 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 635
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 636 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 695
Query: 520 LQKALQEQGGKTEDSILLKRKLEEHLQK----------LHEADLELQRKREYIEELEPPT 569
Q ALQ Q + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 696 FQAALQTQWSWM---LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 752
Query: 570 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPEL 626
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P L
Sbjct: 753 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPLL 810
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1393 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1452
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1453 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1505
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1506 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1565
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1566 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1624
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1684
Query: 532 EDSILLKRKLEEHLQKLHE-----------ADLEL----------QRKREYIEE----LE 566
E ++ + E+ L+K + A+ EL +++R+ +EE L+
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1744
Query: 567 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 626
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1745 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803
Query: 627 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/579 (27%), Positives = 248/579 (42%), Gaps = 90/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1358 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1417
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1418 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1594
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1595 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1644
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1700
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVE--DLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ G Q +Q+L LRA+ E + Q+ L E E+ L+R+ QK
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELARLQREAAAATQKRQ 1755
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1756 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811
Query: 610 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 662
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1812 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1871
Query: 663 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 698
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1872 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1908
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/611 (22%), Positives = 261/611 (42%), Gaps = 75/611 (12%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2104
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2164
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVA----ELQHRNQALTSLAQEAQALKDEMDE 299
Q + E + + E + A++E+E+ +L+ + L +E Q LK E E
Sbjct: 2165 QAADAEMEKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQV----RQLEERNAGHAERTRQLEDE-LRR 354
++ + Q+E L S R ++ EL +L+ ++ R L R+ + +R Q E E +++
Sbjct: 2223 ---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2279
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
A+L ++ L+ Q EE + ++ L E + L+EK ++V +E RL AE + L
Sbjct: 2280 VAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE-KMLKEKMQAV-QEATRLKAEAELL 2336
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
++ E AQ Q R L + + A+ L E + L+ E +R
Sbjct: 2337 QQQKE---LAQEQARRLQEDKEQM-----------AQQLAEETQGFQRTLEAERQRQLEM 2382
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
A E L+ + + +RA+ E + ++Q E+ ++ + A QE+ +
Sbjct: 2383 SA----EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2438
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYI-----------EELEPPTDSSTARRIEELQHN 583
+ +++ + ++L EA EL+R++E + EE++ + + LQ +
Sbjct: 2439 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498
Query: 584 -LQKKDADL---RAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPE-------LHS 628
L +KD+ L R +E+ + + D+ Q E +QR E +
Sbjct: 2499 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2558
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP-AHAQS 687
R + E + +R + + ++ QR Q+E+LL + LQ + RA AH++
Sbjct: 2559 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618
Query: 688 FLAQQRLATNS 698
A Q AT +
Sbjct: 2619 VTASQVAATKT 2629
Score = 88.2 bits (217), Expect = 2e-17
Identities = 144/554 (25%), Positives = 227/554 (40%), Gaps = 78/554 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1599
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1659
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1660 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1838
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1839 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1893
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDSILLKRKLEEHLQKLH-----------EADLELQ 556
+ E AQ+ + L+ Q G ED++ +R++EE + L E +LEL
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 557 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 615
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1954 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2004
Query: 616 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 668 MGMALQQRAGEERA 681
LQQ +E++
Sbjct: 2065 KEQELQQTLQQEQS 2078
Score = 88.2 bits (217), Expect = 2e-17
Identities = 134/541 (24%), Positives = 228/541 (42%), Gaps = 73/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1722 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1781
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1836
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1837 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1893
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2014 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2071
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE----QGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
+ Q L +LR + E ++A +E + ++ +R++EE + A+ + Q
Sbjct: 2072 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2131
Query: 558 KRE---YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 614
+ + E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2132 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2184
Query: 615 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2185 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2240
Query: 668 M 668
M
Sbjct: 2241 M 2241
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/542 (21%), Positives = 225/542 (41%), Gaps = 40/542 (7%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1016 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1075
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1076 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1130
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1131 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1190
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1191 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1250
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1310
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1370
Query: 522 KALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRI--EE 579
AL++Q E K + E ++L + + + E + E D+ +R EE
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQ-----RMQEEVVRREEAAVDAQQQKRSIQEE 1425
Query: 580 LQHNLQKKDADLRA------MEERYR-RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
LQ Q +A+++A ER R R ++ R+V +E +R GA EL +LR +
Sbjct: 1426 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1485
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
E + + R + + E+ R Q + E + A + ++ A R A L +
Sbjct: 1486 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1545
Query: 693 RL 694
RL
Sbjct: 1546 RL 1547
Score = 80.1 bits (196), Expect = 7e-15
Identities = 142/633 (22%), Positives = 250/633 (39%), Gaps = 67/633 (10%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1469
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1470 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1529
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1582
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1642
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1698
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1699 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1758
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1759 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1818
Query: 506 NQQQLSELRA--QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE 563
Q+QL+E A Q + ++ L E+ ++ LK + E L+ E + E +R R E
Sbjct: 1819 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---EKEAENERLRRLAE 1875
Query: 564 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 623
+ ++ RR+EE Q K D + R + R + R +E R
Sbjct: 1876 D-----EAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQRRQVE 1928
Query: 624 PELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMGMALQQRAGEE 679
E+ +L+ + LE++ + RS E +E+ + A +A ++
Sbjct: 1929 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1988
Query: 680 RAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
A Q LA + A R+ L + L +
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/467 (24%), Positives = 195/467 (41%), Gaps = 62/467 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2221 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2272
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2328
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2329 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2376
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2377 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2437 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540
Query: 527 QGGKTE-DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQH 582
Q + E + L +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2541 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2600
Query: 583 NLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
LQ + RA EE V + + + PAA A PE
Sbjct: 2601 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2647
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/469 (21%), Positives = 180/469 (38%), Gaps = 95/469 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 971 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1027
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1028 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1087
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1147
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1206
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1207 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1266
Query: 529 GKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ ++
Sbjct: 1267 EKVEE---CQRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQEY 1320
Query: 589 ADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLE 644
DLR + +Y+ ++ ME ++R A Q E R+ +E
Sbjct: 1321 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAEVE 1370
Query: 645 MDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 693
EK R E + A LQQR EE + AQQ+
Sbjct: 1371 AALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1418
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/479 (21%), Positives = 180/479 (37%), Gaps = 58/479 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 365 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 410
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 411 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 462
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 463 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 522
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 523 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 580
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 581 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 639
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 640 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 699
Query: 520 LQKALQEQGGKTEDSILLKRKLEEHLQK----------LHEADLELQRKREYIEELEPPT 569
Q ALQ Q + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 700 FQAALQTQWSWM---LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 756
Query: 570 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPEL 626
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P L
Sbjct: 757 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPLL 814
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1449 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1501
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1502 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1561
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1562 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1620
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1680
Query: 532 EDSILLKRKLEEHLQKLHE-----------ADLEL----------QRKREYIEE----LE 566
E ++ + E+ L+K + A+ EL +++R+ +EE L+
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1740
Query: 567 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 626
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1741 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799
Query: 627 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/579 (27%), Positives = 248/579 (42%), Gaps = 90/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1413
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1590
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1591 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1640
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVE--DLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ G Q +Q+L LRA+ E + Q+ L E E+ L+R+ QK
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELARLQREAAAATQKRQ 1751
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1752 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 610 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 662
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1867
Query: 663 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 698
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1868 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1904
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/611 (22%), Positives = 261/611 (42%), Gaps = 75/611 (12%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2100
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVA----ELQHRNQALTSLAQEAQALKDEMDE 299
Q + E + + E + A++E+E+ +L+ + L +E Q LK E E
Sbjct: 2161 QAADAEMEKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQV----RQLEERNAGHAERTRQLEDE-LRR 354
++ + Q+E L S R ++ EL +L+ ++ R L R+ + +R Q E E +++
Sbjct: 2219 ---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
A+L ++ L+ Q EE + ++ L E + L+EK ++V +E RL AE + L
Sbjct: 2276 VAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE-KMLKEKMQAV-QEATRLKAEAELL 2332
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
++ E AQ Q R L + + A+ L E + L+ E +R
Sbjct: 2333 QQQKE---LAQEQARRLQEDKEQM-----------AQQLAEETQGFQRTLEAERQRQLEM 2378
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
A E L+ + + +RA+ E + ++Q E+ ++ + A QE+ +
Sbjct: 2379 SA----EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYI-----------EELEPPTDSSTARRIEELQHN 583
+ +++ + ++L EA EL+R++E + EE++ + + LQ +
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 584 -LQKKDADL---RAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPE-------LHS 628
L +KD+ L R +E+ + + D+ Q E +QR E +
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2554
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP-AHAQS 687
R + E + +R + + ++ QR Q+E+LL + LQ + RA AH++
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Query: 688 FLAQQRLATNS 698
A Q AT +
Sbjct: 2615 VTASQVAATKT 2625
Score = 88.2 bits (217), Expect = 2e-17
Identities = 144/554 (25%), Positives = 227/554 (40%), Gaps = 78/554 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1595
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1656 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1834
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1835 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDSILLKRKLEEHLQKLH-----------EADLELQ 556
+ E AQ+ + L+ Q G ED++ +R++EE + L E +LEL
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 557 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 615
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1950 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 616 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 668 MGMALQQRAGEERA 681
LQQ +E++
Sbjct: 2061 KEQELQQTLQQEQS 2074
Score = 88.2 bits (217), Expect = 2e-17
Identities = 134/541 (24%), Positives = 228/541 (42%), Gaps = 73/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1832
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1833 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1889
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2010 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE----QGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
+ Q L +LR + E ++A +E + ++ +R++EE + A+ + Q
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2127
Query: 558 KRE---YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 614
+ + E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2128 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2180
Query: 615 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2181 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2236
Query: 668 M 668
M
Sbjct: 2237 M 2237
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/542 (21%), Positives = 225/542 (41%), Gaps = 40/542 (7%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1071
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1072 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1126
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1127 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 522 KALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRI--EE 579
AL++Q E K + E ++L + + + E + E D+ +R EE
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQ-----RMQEEVVRREEAAVDAQQQKRSIQEE 1421
Query: 580 LQHNLQKKDADLRA------MEERYR-RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
LQ Q +A+++A ER R R ++ R+V +E +R GA EL +LR +
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1481
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
E + + R + + E+ R Q + E + A + ++ A R A L +
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 693 RL 694
RL
Sbjct: 1542 RL 1543
Score = 80.1 bits (196), Expect = 7e-15
Identities = 142/633 (22%), Positives = 250/633 (39%), Gaps = 67/633 (10%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1525
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1578
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1694
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1695 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1754
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1755 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1814
Query: 506 NQQQLSELRA--QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE 563
Q+QL+E A Q + ++ L E+ ++ LK + E L+ E + E +R R E
Sbjct: 1815 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---EKEAENERLRRLAE 1871
Query: 564 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 623
+ ++ RR+EE Q K D + R + R + R +E R
Sbjct: 1872 D-----EAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQRRQVE 1924
Query: 624 PELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMGMALQQRAGEE 679
E+ +L+ + LE++ + RS E +E+ + A +A ++
Sbjct: 1925 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1984
Query: 680 RAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
A Q LA + A R+ L + L +
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/467 (24%), Positives = 195/467 (41%), Gaps = 62/467 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2217 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2268
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2324
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2325 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2372
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2373 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2433 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 527 QGGKTE-DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQH 582
Q + E + L +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2537 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596
Query: 583 NLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
LQ + RA EE V + + + PAA A PE
Sbjct: 2597 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/469 (21%), Positives = 180/469 (38%), Gaps = 95/469 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 967 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1023
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1024 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1143
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1202
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1203 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1262
Query: 529 GKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ ++
Sbjct: 1263 EKVEE---CQRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQEY 1316
Query: 589 ADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLE 644
DLR + +Y+ ++ ME ++R A Q E R+ +E
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAEVE 1366
Query: 645 MDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 693
EK R E + A LQQR EE + AQQ+
Sbjct: 1367 AALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/479 (21%), Positives = 180/479 (37%), Gaps = 58/479 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 361 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 406
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 407 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 458
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 459 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 518
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 519 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 576
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 577 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 635
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 636 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 695
Query: 520 LQKALQEQGGKTEDSILLKRKLEEHLQK----------LHEADLELQRKREYIEELEPPT 569
Q ALQ Q + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 696 FQAALQTQWSWM---LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 752
Query: 570 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPEL 626
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P L
Sbjct: 753 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPLL 810
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1357 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1416
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1417 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1469
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1470 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1529
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1530 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1588
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1648
Query: 532 EDSILLKRKLEEHLQKLHE-----------ADLEL----------QRKREYIEE----LE 566
E ++ + E+ L+K + A+ EL +++R+ +EE L+
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1708
Query: 567 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 626
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1709 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767
Query: 627 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/579 (27%), Positives = 248/579 (42%), Gaps = 90/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1381
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1382 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1558
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1559 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1608
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1664
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVE--DLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ G Q +Q+L LRA+ E + Q+ L E E+ L+R+ QK
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELARLQREAAAATQKRQ 1719
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1720 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775
Query: 610 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 662
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1776 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1835
Query: 663 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 698
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1836 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1872
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/611 (22%), Positives = 261/611 (42%), Gaps = 75/611 (12%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2068
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2128
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVA----ELQHRNQALTSLAQEAQALKDEMDE 299
Q + E + + E + A++E+E+ +L+ + L +E Q LK E E
Sbjct: 2129 QAADAEMEKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQV----RQLEERNAGHAERTRQLEDE-LRR 354
++ + Q+E L S R ++ EL +L+ ++ R L R+ + +R Q E E +++
Sbjct: 2187 ---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2243
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
A+L ++ L+ Q EE + ++ L E + L+EK ++V +E RL AE + L
Sbjct: 2244 VAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE-KMLKEKMQAV-QEATRLKAEAELL 2300
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
++ E AQ Q R L + + A+ L E + L+ E +R
Sbjct: 2301 QQQKE---LAQEQARRLQEDKEQM-----------AQQLAEETQGFQRTLEAERQRQLEM 2346
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
A E L+ + + +RA+ E + ++Q E+ ++ + A QE+ +
Sbjct: 2347 SA----EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2402
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYI-----------EELEPPTDSSTARRIEELQHN 583
+ +++ + ++L EA EL+R++E + EE++ + + LQ +
Sbjct: 2403 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462
Query: 584 -LQKKDADL---RAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPE-------LHS 628
L +KD+ L R +E+ + + D+ Q E +QR E +
Sbjct: 2463 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2522
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP-AHAQS 687
R + E + +R + + ++ QR Q+E+LL + LQ + RA AH++
Sbjct: 2523 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582
Query: 688 FLAQQRLATNS 698
A Q AT +
Sbjct: 2583 VTASQVAATKT 2593
Score = 88.2 bits (217), Expect = 2e-17
Identities = 144/554 (25%), Positives = 227/554 (40%), Gaps = 78/554 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1563
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1623
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1624 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1742
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1802
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1803 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1857
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDSILLKRKLEEHLQKLH-----------EADLELQ 556
+ E AQ+ + L+ Q G ED++ +R++EE + L E +LEL
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 557 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 615
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1918 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 1968
Query: 616 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028
Query: 668 MGMALQQRAGEERA 681
LQQ +E++
Sbjct: 2029 KEQELQQTLQQEQS 2042
Score = 88.2 bits (217), Expect = 2e-17
Identities = 134/541 (24%), Positives = 228/541 (42%), Gaps = 73/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1686 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1745
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1800
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1801 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1857
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 1978 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2035
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE----QGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
+ Q L +LR + E ++A +E + ++ +R++EE + A+ + Q
Sbjct: 2036 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2095
Query: 558 KRE---YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 614
+ + E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2096 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2148
Query: 615 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2149 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2204
Query: 668 M 668
M
Sbjct: 2205 M 2205
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/542 (21%), Positives = 225/542 (41%), Gaps = 40/542 (7%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 980 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1039
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1040 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1094
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1095 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1154
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1155 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1214
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1274
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1334
Query: 522 KALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRI--EE 579
AL++Q E K + E ++L + + + E + E D+ +R EE
Sbjct: 1335 AALEKQRQLAEAHAQAKAQAEREAKELQQ-----RMQEEVVRREEAAVDAQQQKRSIQEE 1389
Query: 580 LQHNLQKKDADLRA------MEERYR-RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
LQ Q +A+++A ER R R ++ R+V +E +R GA EL +LR +
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1449
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
E + + R + + E+ R Q + E + A + ++ A R A L +
Sbjct: 1450 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1509
Query: 693 RL 694
RL
Sbjct: 1510 RL 1511
Score = 80.1 bits (196), Expect = 7e-15
Identities = 142/633 (22%), Positives = 250/633 (39%), Gaps = 67/633 (10%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1433
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1434 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1493
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1546
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1547 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1606
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1607 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1662
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1663 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1722
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1723 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1782
Query: 506 NQQQLSELRA--QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE 563
Q+QL+E A Q + ++ L E+ ++ LK + E L+ E + E +R R E
Sbjct: 1783 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---EKEAENERLRRLAE 1839
Query: 564 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 623
+ ++ RR+EE Q K D + R + R + R +E R
Sbjct: 1840 D-----EAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQRRQVE 1892
Query: 624 PELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMGMALQQRAGEE 679
E+ +L+ + LE++ + RS E +E+ + A +A ++
Sbjct: 1893 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1952
Query: 680 RAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
A Q LA + A R+ L + L +
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/467 (24%), Positives = 195/467 (41%), Gaps = 62/467 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2185 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2236
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2292
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2293 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2340
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2341 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2400
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2401 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 527 QGGKTE-DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQH 582
Q + E + L +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2505 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2564
Query: 583 NLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
LQ + RA EE V + + + PAA A PE
Sbjct: 2565 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2611
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/469 (21%), Positives = 180/469 (38%), Gaps = 95/469 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 935 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 991
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 992 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1051
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1052 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1111
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1170
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1171 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1230
Query: 529 GKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ ++
Sbjct: 1231 EKVEE---CQRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQEY 1284
Query: 589 ADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLE 644
DLR + +Y+ ++ ME ++R A Q E R+ +E
Sbjct: 1285 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAEVE 1334
Query: 645 MDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 693
EK R E + A LQQR EE + AQQ+
Sbjct: 1335 AALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1382
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/479 (21%), Positives = 180/479 (37%), Gaps = 58/479 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 329 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 374
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 375 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 426
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 427 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 486
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 487 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 544
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 545 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 603
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 604 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 663
Query: 520 LQKALQEQGGKTEDSILLKRKLEEHLQK----------LHEADLELQRKREYIEELEPPT 569
Q ALQ Q + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 664 FQAALQTQWSWM---LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 720
Query: 570 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPEL 626
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P L
Sbjct: 721 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPLL 778
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1526 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1585
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1586 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1638
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1639 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1699 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1757
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1817
Query: 532 EDSILLKRKLEEHLQKLHE-----------ADLEL----------QRKREYIEE----LE 566
E ++ + E+ L+K + A+ EL +++R+ +EE L+
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1877
Query: 567 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 626
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1878 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936
Query: 627 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/579 (27%), Positives = 248/579 (42%), Gaps = 90/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1491 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1550
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1551 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1610
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1727
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1728 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1777
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1833
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVE--DLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ G Q +Q+L LRA+ E + Q+ L E E+ L+R+ QK
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELARLQREAAAATQKRQ 1888
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1889 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944
Query: 610 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 662
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1945 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 2004
Query: 663 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 698
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 2005 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 2041
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/611 (22%), Positives = 261/611 (42%), Gaps = 75/611 (12%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2237
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVA----ELQHRNQALTSLAQEAQALKDEMDE 299
Q + E + + E + A++E+E+ +L+ + L +E Q LK E E
Sbjct: 2298 QAADAEMEKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQV----RQLEERNAGHAERTRQLEDE-LRR 354
++ + Q+E L S R ++ EL +L+ ++ R L R+ + +R Q E E +++
Sbjct: 2356 ---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
A+L ++ L+ Q EE + ++ L E + L+EK ++V +E RL AE + L
Sbjct: 2413 VAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE-KMLKEKMQAV-QEATRLKAEAELL 2469
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
++ E AQ Q R L + + A+ L E + L+ E +R
Sbjct: 2470 QQQKE---LAQEQARRLQEDKEQM-----------AQQLAEETQGFQRTLEAERQRQLEM 2515
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
A E L+ + + +RA+ E + ++Q E+ ++ + A QE+ +
Sbjct: 2516 SA----EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2571
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYI-----------EELEPPTDSSTARRIEELQHN 583
+ +++ + ++L EA EL+R++E + EE++ + + LQ +
Sbjct: 2572 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631
Query: 584 -LQKKDADL---RAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPE-------LHS 628
L +KD+ L R +E+ + + D+ Q E +QR E +
Sbjct: 2632 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2691
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP-AHAQS 687
R + E + +R + + ++ QR Q+E+LL + LQ + RA AH++
Sbjct: 2692 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751
Query: 688 FLAQQRLATNS 698
A Q AT +
Sbjct: 2752 VTASQVAATKT 2762
Score = 88.2 bits (217), Expect = 2e-17
Identities = 144/554 (25%), Positives = 227/554 (40%), Gaps = 78/554 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1732
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1793 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1972 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 2026
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDSILLKRKLEEHLQKLH-----------EADLELQ 556
+ E AQ+ + L+ Q G ED++ +R++EE + L E +LEL
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 557 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 615
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 2087 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2137
Query: 616 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197
Query: 668 MGMALQQRAGEERA 681
LQQ +E++
Sbjct: 2198 KEQELQQTLQQEQS 2211
Score = 88.2 bits (217), Expect = 2e-17
Identities = 134/541 (24%), Positives = 228/541 (42%), Gaps = 73/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1969
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1970 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 2026
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2147 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2204
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE----QGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
+ Q L +LR + E ++A +E + ++ +R++EE + A+ + Q
Sbjct: 2205 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2264
Query: 558 KRE---YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 614
+ + E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2317
Query: 615 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2318 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2373
Query: 668 M 668
M
Sbjct: 2374 M 2374
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/542 (21%), Positives = 225/542 (41%), Gaps = 40/542 (7%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1149 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1208
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1209 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1263
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1264 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1323
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503
Query: 522 KALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRI--EE 579
AL++Q E K + E ++L + + + E + E D+ +R EE
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQ-----RMQEEVVRREEAAVDAQQQKRSIQEE 1558
Query: 580 LQHNLQKKDADLRA------MEERYR-RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
LQ Q +A+++A ER R R ++ R+V +E +R GA EL +LR +
Sbjct: 1559 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1618
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
E + + R + + E+ R Q + E + A + ++ A R A L +
Sbjct: 1619 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1678
Query: 693 RL 694
RL
Sbjct: 1679 RL 1680
Score = 80.1 bits (196), Expect = 7e-15
Identities = 142/633 (22%), Positives = 250/633 (39%), Gaps = 67/633 (10%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1602
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1603 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1662
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1715
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1831
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1832 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1891
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951
Query: 506 NQQQLSELRA--QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE 563
Q+QL+E A Q + ++ L E+ ++ LK + E L+ E + E +R R E
Sbjct: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---EKEAENERLRRLAE 2008
Query: 564 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 623
+ ++ RR+EE Q K D + R + R + R +E R
Sbjct: 2009 D-----EAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQRRQVE 2061
Query: 624 PELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMGMALQQRAGEE 679
E+ +L+ + LE++ + RS E +E+ + A +A ++
Sbjct: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2121
Query: 680 RAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
A Q LA + A R+ L + L +
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/467 (24%), Positives = 195/467 (41%), Gaps = 62/467 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2354 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2405
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2461
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2462 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2509
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2510 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2569
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2570 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673
Query: 527 QGGKTE-DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQH 582
Q + E + L +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2674 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2733
Query: 583 NLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
LQ + RA EE V + + + PAA A PE
Sbjct: 2734 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2780
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/469 (21%), Positives = 180/469 (38%), Gaps = 95/469 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 1104 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1160
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1161 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1220
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1280
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1339
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1340 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1399
Query: 529 GKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ ++
Sbjct: 1400 EKVEE---CQRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQEY 1453
Query: 589 ADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLE 644
DLR + +Y+ ++ ME ++R A Q E R+ +E
Sbjct: 1454 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAEVE 1503
Query: 645 MDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 693
EK R E + A LQQR EE + AQQ+
Sbjct: 1504 AALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1551
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/479 (21%), Positives = 180/479 (37%), Gaps = 58/479 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 498 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 543
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 544 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 595
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 596 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 655
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 656 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 713
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 714 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 772
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 773 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 832
Query: 520 LQKALQEQGGKTEDSILLKRKLEEHLQK----------LHEADLELQRKREYIEELEPPT 569
Q ALQ Q + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 833 FQAALQTQWSWM---LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 889
Query: 570 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPEL 626
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P L
Sbjct: 890 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPLL 947
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1367 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1426
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1427 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1479
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1480 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1540 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1598
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
Query: 532 EDSILLKRKLEEHLQKLHE-----------ADLEL----------QRKREYIEE----LE 566
E ++ + E+ L+K + A+ EL +++R+ +EE L+
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718
Query: 567 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 626
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1719 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777
Query: 627 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/579 (27%), Positives = 248/579 (42%), Gaps = 90/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1332 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1391
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1392 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1451
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1511
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1568
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1569 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1618
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1674
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVE--DLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ G Q +Q+L LRA+ E + Q+ L E E+ L+R+ QK
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELARLQREAAAATQKRQ 1729
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1730 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
Query: 610 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 662
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1786 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1845
Query: 663 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 698
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1846 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1882
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/611 (22%), Positives = 261/611 (42%), Gaps = 75/611 (12%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2078
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVA----ELQHRNQALTSLAQEAQALKDEMDE 299
Q + E + + E + A++E+E+ +L+ + L +E Q LK E E
Sbjct: 2139 QAADAEMEKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQV----RQLEERNAGHAERTRQLEDE-LRR 354
++ + Q+E L S R ++ EL +L+ ++ R L R+ + +R Q E E +++
Sbjct: 2197 ---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
A+L ++ L+ Q EE + ++ L E + L+EK ++V +E RL AE + L
Sbjct: 2254 VAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE-KMLKEKMQAV-QEATRLKAEAELL 2310
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
++ E AQ Q R L + + A+ L E + L+ E +R
Sbjct: 2311 QQQKE---LAQEQARRLQEDKEQM-----------AQQLAEETQGFQRTLEAERQRQLEM 2356
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
A E L+ + + +RA+ E + ++Q E+ ++ + A QE+ +
Sbjct: 2357 SA----EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2412
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYI-----------EELEPPTDSSTARRIEELQHN 583
+ +++ + ++L EA EL+R++E + EE++ + + LQ +
Sbjct: 2413 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472
Query: 584 -LQKKDADL---RAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPE-------LHS 628
L +KD+ L R +E+ + + D+ Q E +QR E +
Sbjct: 2473 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2532
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP-AHAQS 687
R + E + +R + + ++ QR Q+E+LL + LQ + RA AH++
Sbjct: 2533 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
Query: 688 FLAQQRLATNS 698
A Q AT +
Sbjct: 2593 VTASQVAATKT 2603
Score = 88.2 bits (217), Expect = 2e-17
Identities = 144/554 (25%), Positives = 227/554 (40%), Gaps = 78/554 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1573
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1634 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1813 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1867
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDSILLKRKLEEHLQKLH-----------EADLELQ 556
+ E AQ+ + L+ Q G ED++ +R++EE + L E +LEL
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 557 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 615
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1928 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 1978
Query: 616 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038
Query: 668 MGMALQQRAGEERA 681
LQQ +E++
Sbjct: 2039 KEQELQQTLQQEQS 2052
Score = 88.2 bits (217), Expect = 2e-17
Identities = 134/541 (24%), Positives = 228/541 (42%), Gaps = 73/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1696 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1755
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1810
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1811 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1867
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 1988 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2045
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE----QGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
+ Q L +LR + E ++A +E + ++ +R++EE + A+ + Q
Sbjct: 2046 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2105
Query: 558 KRE---YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 614
+ + E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2106 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2158
Query: 615 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2159 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2214
Query: 668 M 668
M
Sbjct: 2215 M 2215
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/542 (21%), Positives = 225/542 (41%), Gaps = 40/542 (7%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 990 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1049
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1050 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1104
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1105 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1164
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
Query: 522 KALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRI--EE 579
AL++Q E K + E ++L + + + E + E D+ +R EE
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQ-----RMQEEVVRREEAAVDAQQQKRSIQEE 1399
Query: 580 LQHNLQKKDADLRA------MEERYR-RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
LQ Q +A+++A ER R R ++ R+V +E +R GA EL +LR +
Sbjct: 1400 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1459
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
E + + R + + E+ R Q + E + A + ++ A R A L +
Sbjct: 1460 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1519
Query: 693 RL 694
RL
Sbjct: 1520 RL 1521
Score = 80.1 bits (196), Expect = 7e-15
Identities = 142/633 (22%), Positives = 250/633 (39%), Gaps = 67/633 (10%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1443
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1444 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1503
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1556
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1557 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1616
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1617 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1672
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1673 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1732
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
Query: 506 NQQQLSELRA--QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE 563
Q+QL+E A Q + ++ L E+ ++ LK + E L+ E + E +R R E
Sbjct: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---EKEAENERLRRLAE 1849
Query: 564 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 623
+ ++ RR+EE Q K D + R + R + R +E R
Sbjct: 1850 D-----EAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQRRQVE 1902
Query: 624 PELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMGMALQQRAGEE 679
E+ +L+ + LE++ + RS E +E+ + A +A ++
Sbjct: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1962
Query: 680 RAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
A Q LA + A R+ L + L +
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/467 (24%), Positives = 195/467 (41%), Gaps = 62/467 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2195 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2246
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2302
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2303 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2350
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2351 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2410
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2411 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514
Query: 527 QGGKTE-DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQH 582
Q + E + L +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2515 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2574
Query: 583 NLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
LQ + RA EE V + + + PAA A PE
Sbjct: 2575 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2621
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/469 (21%), Positives = 180/469 (38%), Gaps = 95/469 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 945 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1001
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1002 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1061
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1062 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1121
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1180
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1181 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1240
Query: 529 GKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ ++
Sbjct: 1241 EKVEE---CQRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQEY 1294
Query: 589 ADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLE 644
DLR + +Y+ ++ ME ++R A Q E R+ +E
Sbjct: 1295 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAEVE 1344
Query: 645 MDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 693
EK R E + A LQQR EE + AQQ+
Sbjct: 1345 AALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1392
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/479 (21%), Positives = 180/479 (37%), Gaps = 58/479 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 339 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 384
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 385 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 436
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 437 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 496
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 497 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 554
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 555 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 613
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 614 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 673
Query: 520 LQKALQEQGGKTEDSILLKRKLEEHLQK----------LHEADLELQRKREYIEELEPPT 569
Q ALQ Q + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 674 FQAALQTQWSWM---LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 730
Query: 570 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPEL 626
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P L
Sbjct: 731 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPLL 788
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1375 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1434
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1435 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1487
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1488 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1547
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1548 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1606
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1666
Query: 532 EDSILLKRKLEEHLQKLHE-----------ADLEL----------QRKREYIEE----LE 566
E ++ + E+ L+K + A+ EL +++R+ +EE L+
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1726
Query: 567 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 626
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1727 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785
Query: 627 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/579 (27%), Positives = 248/579 (42%), Gaps = 90/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1340 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1399
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1400 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1459
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1519
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1576
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1577 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1626
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1682
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVE--DLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ G Q +Q+L LRA+ E + Q+ L E E+ L+R+ QK
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELARLQREAAAATQKRQ 1737
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1738 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793
Query: 610 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 662
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1794 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1853
Query: 663 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 698
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1854 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1890
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/611 (22%), Positives = 261/611 (42%), Gaps = 75/611 (12%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2086
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2146
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVA----ELQHRNQALTSLAQEAQALKDEMDE 299
Q + E + + E + A++E+E+ +L+ + L +E Q LK E E
Sbjct: 2147 QAADAEMEKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQV----RQLEERNAGHAERTRQLEDE-LRR 354
++ + Q+E L S R ++ EL +L+ ++ R L R+ + +R Q E E +++
Sbjct: 2205 ---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2261
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
A+L ++ L+ Q EE + ++ L E + L+EK ++V +E RL AE + L
Sbjct: 2262 VAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE-KMLKEKMQAV-QEATRLKAEAELL 2318
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
++ E AQ Q R L + + A+ L E + L+ E +R
Sbjct: 2319 QQQKE---LAQEQARRLQEDKEQM-----------AQQLAEETQGFQRTLEAERQRQLEM 2364
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
A E L+ + + +RA+ E + ++Q E+ ++ + A QE+ +
Sbjct: 2365 SA----EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2420
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYI-----------EELEPPTDSSTARRIEELQHN 583
+ +++ + ++L EA EL+R++E + EE++ + + LQ +
Sbjct: 2421 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2480
Query: 584 -LQKKDADL---RAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPE-------LHS 628
L +KD+ L R +E+ + + D+ Q E +QR E +
Sbjct: 2481 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2540
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP-AHAQS 687
R + E + +R + + ++ QR Q+E+LL + LQ + RA AH++
Sbjct: 2541 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2600
Query: 688 FLAQQRLATNS 698
A Q AT +
Sbjct: 2601 VTASQVAATKT 2611
Score = 88.2 bits (217), Expect = 2e-17
Identities = 144/554 (25%), Positives = 227/554 (40%), Gaps = 78/554 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1581
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1641
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1642 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1760
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1820
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1821 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1875
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDSILLKRKLEEHLQKLH-----------EADLELQ 556
+ E AQ+ + L+ Q G ED++ +R++EE + L E +LEL
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 557 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 615
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1936 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 1986
Query: 616 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046
Query: 668 MGMALQQRAGEERA 681
LQQ +E++
Sbjct: 2047 KEQELQQTLQQEQS 2060
Score = 88.2 bits (217), Expect = 2e-17
Identities = 134/541 (24%), Positives = 228/541 (42%), Gaps = 73/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1704 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1763
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1818
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1819 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1875
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 1996 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2053
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE----QGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
+ Q L +LR + E ++A +E + ++ +R++EE + A+ + Q
Sbjct: 2054 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2113
Query: 558 KRE---YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 614
+ + E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2114 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2166
Query: 615 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2167 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2222
Query: 668 M 668
M
Sbjct: 2223 M 2223
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/542 (21%), Positives = 225/542 (41%), Gaps = 40/542 (7%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 998 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1057
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1058 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1112
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1113 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1172
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1173 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1232
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1233 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1292
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1293 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1352
Query: 522 KALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRI--EE 579
AL++Q E K + E ++L + + + E + E D+ +R EE
Sbjct: 1353 AALEKQRQLAEAHAQAKAQAEREAKELQQ-----RMQEEVVRREEAAVDAQQQKRSIQEE 1407
Query: 580 LQHNLQKKDADLRA------MEERYR-RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
LQ Q +A+++A ER R R ++ R+V +E +R GA EL +LR +
Sbjct: 1408 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1467
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
E + + R + + E+ R Q + E + A + ++ A R A L +
Sbjct: 1468 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1527
Query: 693 RL 694
RL
Sbjct: 1528 RL 1529
Score = 80.1 bits (196), Expect = 7e-15
Identities = 142/633 (22%), Positives = 250/633 (39%), Gaps = 67/633 (10%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1392 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1451
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1452 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1511
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1564
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1565 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1624
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1625 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1680
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1681 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1740
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1741 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1800
Query: 506 NQQQLSELRA--QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE 563
Q+QL+E A Q + ++ L E+ ++ LK + E L+ E + E +R R E
Sbjct: 1801 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---EKEAENERLRRLAE 1857
Query: 564 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 623
+ ++ RR+EE Q K D + R + R + R +E R
Sbjct: 1858 D-----EAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQRRQVE 1910
Query: 624 PELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMGMALQQRAGEE 679
E+ +L+ + LE++ + RS E +E+ + A +A ++
Sbjct: 1911 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 1970
Query: 680 RAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
A Q LA + A R+ L + L +
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/467 (24%), Positives = 195/467 (41%), Gaps = 62/467 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2203 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2254
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2310
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2311 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2358
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2359 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2418
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2419 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522
Query: 527 QGGKTE-DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQH 582
Q + E + L +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2523 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2582
Query: 583 NLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
LQ + RA EE V + + + PAA A PE
Sbjct: 2583 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2629
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/469 (21%), Positives = 180/469 (38%), Gaps = 95/469 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 953 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1009
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1010 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1069
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1070 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1129
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1130 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1188
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1189 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1248
Query: 529 GKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ ++
Sbjct: 1249 EKVEE---CQRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQEY 1302
Query: 589 ADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLE 644
DLR + +Y+ ++ ME ++R A Q E R+ +E
Sbjct: 1303 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAEVE 1352
Query: 645 MDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 693
EK R E + A LQQR EE + AQQ+
Sbjct: 1353 AALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1400
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/479 (21%), Positives = 180/479 (37%), Gaps = 58/479 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 347 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 392
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 393 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 444
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 445 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 504
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 505 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 562
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 563 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 621
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 622 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 681
Query: 520 LQKALQEQGGKTEDSILLKRKLEEHLQK----------LHEADLELQRKREYIEELEPPT 569
Q ALQ Q + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 682 FQAALQTQWSWM---LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 738
Query: 570 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPEL 626
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P L
Sbjct: 739 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPLL 796
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 98.6 bits (244), Expect = 2e-20
Identities = 131/536 (24%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE---------------------R 271
LT++ + + L +++EE E R +ER R AE+E R
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415
Query: 272 EVAELQHRNQ--------ALTSLAQEAQALKDEMDELRQSSE-----RAGQLEATLTSCR 318
E ELQ R Q A Q+ +++++E+ +LRQSSE +A Q EA S
Sbjct: 1416 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1475
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQG 374
R E+R +R Q+ E + G E EL+ + + EAQ+RQ QE L+
Sbjct: 1476 RIEEEIRVVRLQLEATERQRGG-------AEGELQALRARAEEAEAQKRQAQEEAERLRR 1528
Query: 375 QRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR----EANEELRCAQLQPRG 430
Q Q+E+ + + E + + +EK+R L + LR EA LR A+++
Sbjct: 1529 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1588
Query: 431 LTQ---------ADPSLDPTSTPVDNLAAEILPAELRE---TLLRLQLENKRLCRQEAAD 478
Q A+ L A+ L L+E + +L+ E +R +Q+A
Sbjct: 1589 QVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLREEAERRAQQQAEA 1647
Query: 479 RERQEELQRHLE----DANRA-RHGLETQHRLNQQQLSELRA--QVEDLQKALQEQGGKT 531
+EE +R LE AN A R L+ + Q+ L++ A Q E+ ++ + +G
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1707
Query: 532 EDSILLKRKLEEHLQKLHE-----------ADLEL----------QRKREYIEE----LE 566
E ++ + E+ L+K + A+ EL +++R+ +EE L+
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1767
Query: 567 PPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPEL 626
++T +R +EL+ L K A++ + R +++R + + + AG EL
Sbjct: 1768 REAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826
Query: 627 HSLRTQLRE-RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERA 681
+LR + R ++ E + QR + E++L +G A + + E A
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882
Score = 93.6 bits (231), Expect = 6e-19
Identities = 157/579 (27%), Positives = 248/579 (42%), Gaps = 90/579 (15%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTA-----K 236
+ AEE + L + LE+Q L Q+ AQ +E R + E A +
Sbjct: 1381 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1440
Query: 237 KLLLLQSQLEQL-------------QEENFRLESGREDERLRCAELEREVAELQHRN--- 280
+ +Q +L+QL Q E R +E +R L+ E E Q
Sbjct: 1441 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500
Query: 281 --QALTSLAQEAQALK----DEMDELRQ----SSERAGQLEATLTSCRRRLGE-LRELRR 329
QAL + A+EA+A K +E + LR+ S+R Q E L S + E RE +R
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1560
Query: 330 QVRQLEERNAGHAERTRQL-EDELRRAGSLRAQLE-AQRRQVQELQGQRQEEAMKAEKWL 387
++ LEE E R+L + E+ RA ++ LE AQR ELQ +R A AEK
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR---ASFAEKTA 1617
Query: 388 FECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN 447
R+L+E++ +V + +E AER + ++A E R +A+ L+ +
Sbjct: 1618 QLERSLQEEHVAVAQLREE--AERRAQQQAEAE--------RAREEAERELERWQLKANE 1667
Query: 448 LAAEILPAE---LRETLLRLQLENKRLCRQEAADRE------------RQEEL-QRHLED 491
L AE +++L + + E ++ E A+RE RQ EL ++ LE
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQK----EEAEREARRRGKAEEQAVRQRELAEQELEK 1723
Query: 492 ANRARHGLETQHRLNQQQLSELRAQVE--DLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ G Q +Q+L LRA+ E + Q+ L E E+ L+R+ QK
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELARLQREAAAATQKRQ 1778
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
E + EL + R +E L +S AR EE + +K L A R+R ++A +
Sbjct: 1779 ELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
Query: 610 QTMEPKQRPAAGAPPELHSLRTQ----LRERDVRI---RHLEMDFEKSRSQREQEEKLLI 662
E +R A + R + L E+ I L+ + E + ++E E + L
Sbjct: 1835 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLR 1894
Query: 663 SAWYNMGMALQQRAGEERAPAH---AQSFLAQQRLATNS 698
+ A Q+R EE+A H + LAQ R A++S
Sbjct: 1895 RLAED--EAFQRRRLEEQAAQHKADIEERLAQLRKASDS 1931
Score = 91.3 bits (225), Expect = 3e-18
Identities = 139/611 (22%), Positives = 261/611 (42%), Gaps = 75/611 (12%)
Query: 133 QRIMTLEESVQHVVMEAIQELM-TKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD--- 188
+R+ E++ V + QEL T S+ + G ++ R +EEAEE
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA----AEEAEEARVQA 2127
Query: 189 -----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQS 243
+ +++ + ER E+ Q+ AQ A + E E A++ L Q
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
Query: 244 QLEQLQEENFRLESGREDERLRCAELEREVA----ELQHRNQALTSLAQEAQALKDEMDE 299
Q + E + + E + A++E+E+ +L+ + L +E Q LK E E
Sbjct: 2188 QAADAEMEKHKKFA--EQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQV----RQLEERNAGHAERTRQLEDE-LRR 354
++ + Q+E L S R ++ EL +L+ ++ R L R+ + +R Q E E +++
Sbjct: 2246 ---AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
A+L ++ L+ Q EE + ++ L E + L+EK ++V +E RL AE + L
Sbjct: 2303 VAEEAARLSVAAQEAARLR-QLAEEDLAQQRALAE-KMLKEKMQAV-QEATRLKAEAELL 2359
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
++ E AQ Q R L + + A+ L E + L+ E +R
Sbjct: 2360 QQQKE---LAQEQARRLQEDKEQM-----------AQQLAEETQGFQRTLEAERQRQLEM 2405
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
A E L+ + + +RA+ E + ++Q E+ ++ + A QE+ +
Sbjct: 2406 SA----EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2461
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYI-----------EELEPPTDSSTARRIEELQHN 583
+ +++ + ++L EA EL+R++E + EE++ + + LQ +
Sbjct: 2462 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521
Query: 584 -LQKKDADL---RAMEERYRR----YVDKARMVMQTMEPKQRPAAGAPPE-------LHS 628
L +KD+ L R +E+ + + D+ Q E +QR E +
Sbjct: 2522 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2581
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAP-AHAQS 687
R + E + +R + + ++ QR Q+E+LL + LQ + RA AH++
Sbjct: 2582 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2641
Query: 688 FLAQQRLATNS 698
A Q AT +
Sbjct: 2642 VTASQVAATKT 2652
Score = 88.2 bits (217), Expect = 2e-17
Identities = 144/554 (25%), Positives = 227/554 (40%), Gaps = 78/554 (14%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+ + + ER+L E+ Q +R E + A+K L+
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE---RS 1622
Query: 248 LQEENFRLESGREDERLRC---AELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ-- 302
LQEE+ + RE+ R AE ER E + + A EA L+ + +E+ Q
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1682
Query: 303 ---SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN--------AGHAERTRQLEDE 351
+E Q E RRR G+ E + R+L E+ G A++ E E
Sbjct: 1683 SLAQAEAEKQKEEAEREARRR-GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Query: 352 LRRAGSLRAQLEAQRRQVQELQGQRQEEA----------------MKAEKWLF---ECRN 392
L R + Q E QR+ ++E + Q EA ++AE + + R
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801
Query: 393 LEEKYESVTKEKERLLAERDSLREANEE---LRC-AQLQPRGLTQADPSLDPTSTPVDNL 448
EE + K K+RL AE RE EE LR A+ R A+ + +
Sbjct: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1861
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
AE L A T RL+ E + +++ A+ ER L+R ED R LE Q ++
Sbjct: 1862 LAEKLAAIGEAT--RLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAAQHKA 1916
Query: 509 QLSELRAQVEDLQKA-LQEQGGKTEDSILLKRKLEEHLQKLH-----------EADLELQ 556
+ E AQ+ + L+ Q G ED++ +R++EE + L E +LEL
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 557 RKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYV-DKARMVMQTMEPK 615
R R E D+ ++ EL+ Q++ L A EER RR ++ + + E
Sbjct: 1977 RIRSNAE------DTLRSKEQAELEAARQRQ---LAAEEERRRREAEERVQKSLAAEEEA 2027
Query: 616 QRPAAGAPPELHSLRT------QLRER--DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
R A E+ L+ +LRER R L++ E ++ + + EEK A
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087
Query: 668 MGMALQQRAGEERA 681
LQQ +E++
Sbjct: 2088 KEQELQQTLQQEQS 2101
Score = 88.2 bits (217), Expect = 2e-17
Identities = 134/541 (24%), Positives = 228/541 (42%), Gaps = 73/541 (13%)
Query: 180 LSEEAEEGDE----LQQRCLDLERQLMLLSEEKQSLAQENAGLRERM---------GRPE 226
L E E+G++ L++ L+R+ ++++Q L E A +R M E
Sbjct: 1745 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1804
Query: 227 GEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAE---LQHRNQAL 283
T + ++L + +L EE RL + E+ A+ +R++AE + R +A
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE-----AKRQRQLAEEDAARQRAEAE 1859
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA- 342
LA++ A+ E L+ +E A + + RRL E +R R+LEE+ A H
Sbjct: 1860 RVLAEKLAAI-GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR--RRLEEQAAQHKA 1916
Query: 343 ---ERTRQL----EDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECR 391
ER QL + EL R L QRRQV+E L+ ++ A + E
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 392 NLEEKYESVTKEKER--LLAERDSLREANEELRCAQLQPR------GLTQADPSLDPTST 443
+ E + KE+ L A R A EE R + + R +A
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
Query: 444 PVDNLAAEILPAELRETLLRLQLENKRLCR--QEAADRERQEELQRHLEDANRARHGLET 501
V+ L A++ E R R + E+ R + QEAA + Q E + H + L+
Sbjct: 2037 EVERLKAKV--EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2094
Query: 502 QHRLNQQQLSELRAQVEDLQKALQE----QGGKTEDSILLKRKLEEHLQKLHEADLELQR 557
+ Q L +LR + E ++A +E + ++ +R++EE + A+ + Q
Sbjct: 2095 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA 2154
Query: 558 KRE---YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEP 614
+ + E+L + ARR + Q L++K A A E+++++ + QT+
Sbjct: 2155 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE------QTLRQ 2207
Query: 615 KQRPAAGAPPELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEKLLISAWYN 667
K A EL +LR QL E D ++ L+ + ++ QR Q E+ L S
Sbjct: 2208 K----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQ 2263
Query: 668 M 668
M
Sbjct: 2264 M 2264
Score = 81.3 bits (199), Expect = 3e-15
Identities = 115/542 (21%), Positives = 225/542 (41%), Gaps = 40/542 (7%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
+ E E QR + ++ + + +A+ +A + + PE +L L
Sbjct: 1039 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1098
Query: 243 SQLEQLQEENFRLESGREDERLRCAELE-REVAELQHRNQALTSLAQEAQALKDEMDELR 301
+LEQ+ R S E+L+ L R + +A +EAQA+ + EL
Sbjct: 1099 GKLEQV-----RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1153
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER-NAGHAERTRQLE-------DELR 353
+ +L A + + LR+ R +++ ER H ER ++E L
Sbjct: 1154 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1213
Query: 354 RAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKWLFECRNLEEKYESV-----TKEKE 405
R ++ AQ + ++R++++L Q +E A WL + R +E+ +++ +E
Sbjct: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273
Query: 406 RLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ 465
+L E+ L E + R Q ++ + A++ P ++Q
Sbjct: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Query: 466 LENKRLCRQEAADRERQEEL----QRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQ 521
++ + ++ R EL ++++ + +E + RL +QQ +E R ++ +++
Sbjct: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
Query: 522 KALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRI--EE 579
AL++Q E K + E ++L + + + E + E D+ +R EE
Sbjct: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQ-----RMQEEVVRREEAAVDAQQQKRSIQEE 1448
Query: 580 LQHNLQKKDADLRA------MEERYR-RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
LQ Q +A+++A ER R R ++ R+V +E +R GA EL +LR +
Sbjct: 1449 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1508
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
E + + R + + E+ R Q + E + A + ++ A R A L +
Sbjct: 1509 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1568
Query: 693 RL 694
RL
Sbjct: 1569 RL 1570
Score = 80.1 bits (196), Expect = 7e-15
Identities = 142/633 (22%), Positives = 250/633 (39%), Gaps = 67/633 (10%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
E D Q+ +++E +Q + + E+ K + + + + R E E
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1492
Query: 186 ------EGD--ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKK 237
EG+ L+ R + E Q EE + L ++ +R + E E + A+
Sbjct: 1493 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1552
Query: 238 LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
+ Q E RL++ + RLR AE+ER Q +L ++ + E+
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVER-------ARQVQVALETAQRSAEAEL 1605
Query: 298 DELRQS-SERAGQLEATLTSCRRRLGELR-ELRRQVRQLEERNAGHAERTRQLED-ELRR 354
R S +E+ QLE +L + +LR E R+ +Q E E R+LE +L+
Sbjct: 1606 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1665
Query: 355 AGSLRAQLE----AQRRQVQELQGQRQEEAM--------KAEKWLFECRNLEEKYESVTK 402
+LR +L+ AQ++ + + + ++Q+E KAE+ R L E+
Sbjct: 1666 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ----EL 1721
Query: 403 EKERLLAERDSLREANEELRCAQL--------QPRGLTQADPSLDPTSTPVDNLAAEILP 454
EK+R LAE + + E +L Q R L + + + + L
Sbjct: 1722 EKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE 1781
Query: 455 AELRETLLRLQLENKRLCRQEAADRERQEELQRHLE-DANRARHGLETQHRL-------- 505
AEL + +++ R E R E+ ++ LE +A R R E RL
Sbjct: 1782 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1841
Query: 506 NQQQLSELRA--QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE 563
Q+QL+E A Q + ++ L E+ ++ LK + E L+ E + E +R R E
Sbjct: 1842 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK---EKEAENERLRRLAE 1898
Query: 564 ELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 623
+ ++ RR+EE Q K D + R + R + R +E R
Sbjct: 1899 D-----EAFQRRRLEE-QAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQRRQVE 1951
Query: 624 PELHSLRTQLRERDVRIRHLEMDFEKSRSQRE----QEEKLLISAWYNMGMALQQRAGEE 679
E+ +L+ + LE++ + RS E +E+ + A +A ++
Sbjct: 1952 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRR 2011
Query: 680 RAPAHAQSFLAQQRLATNSRRGPLGRLASLNLR 712
A Q LA + A R+ L + L +
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
Score = 70.9 bits (172), Expect = 4e-12
Identities = 114/467 (24%), Positives = 195/467 (41%), Gaps = 62/467 (13%)
Query: 181 SEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL 240
+E A + ++++ + Q+ LS+ K + EN L R T + L
Sbjct: 2244 TEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR--------DKDNTQRFLQE 2295
Query: 241 LQSQLEQLQEENFRLE-SGREDERLRCAELE-----REVAE--LQHRNQALTSLAQEAQA 292
+++Q+ EE RL + +E RLR E R +AE L+ + QA+ QEA
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAV----QEATR 2351
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL 352
LK E + L+Q E A + RRL E +E + +QL E G R LE E
Sbjct: 2352 LKAEAELLQQQKELAQEQA-------RRLQEDKE--QMAQQLAEETQGFQ---RTLEAER 2399
Query: 353 RRAGSLRAQLEAQRRQVQEL---QGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+R + A+ E + +V E+ Q + +E+A + K E + E T+EK L+
Sbjct: 2400 QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2459
Query: 410 ERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENK 469
+ R+ Q+D + + L E + LL+L+ E
Sbjct: 2460 TLEIQRQ----------------QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503
Query: 470 RLCRQEAADRERQEELQRHLEDAN---RARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +QE +E Q Q L + + + +E + +Q + A+ + L++ Q
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563
Query: 527 QGGKTE-DSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT---DSSTARRIEELQH 582
Q + E + L +EE ++ HEA+ ++RK+E +++LE + A + L+
Sbjct: 2564 QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLRE 2623
Query: 583 NLQKKDADLRAM----EERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
LQ + RA EE V + + + PAA A PE
Sbjct: 2624 QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2670
Score = 54.7 bits (130), Expect = 3e-07
Identities = 100/469 (21%), Positives = 180/469 (38%), Gaps = 95/469 (20%)
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERN-------------------- 338
+L QS E+ Q E+ C+R + EL+++R Q+ E R
Sbjct: 994 QLLQSLEQGAQEESR---CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRI 1050
Query: 339 --------------------AGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG---- 374
+ AE+ L + A +LR++LE ++++++
Sbjct: 1051 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1110
Query: 375 ---------------QRQEEAMKA-EKWLFECR-------NLEEKYESVTKEKERLLAER 411
Q EE ++A E+ L E + LE S+ K + + A++
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQ 1170
Query: 412 DSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEIL---PAELRETLLRLQLEN 468
+ +ELR AQ L Q D A++L A L +T +R Q E
Sbjct: 1171 PTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR-QREL 1229
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQG 528
++L RQ RE + L L+DA R + ++ + Q + E Q + L + ++ G
Sbjct: 1230 EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1289
Query: 529 GKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
K E+ +R ++++ + + +L+L Y +LEP + +++ ++ ++
Sbjct: 1290 EKVEE---CQRFAKQYINAIKDYELQLV---TYKAQLEPVASPAKKPKVQSGSESVIQEY 1343
Query: 589 ADLRA----MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLE 644
DLR + +Y+ ++ ME ++R A Q E R+ +E
Sbjct: 1344 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA----------EQQRAEERERLAEVE 1393
Query: 645 MDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQR 693
EK R E + A LQQR EE + AQQ+
Sbjct: 1394 AALEKQRQLAEAHAQAKAQA-EREAKELQQRMQEEVVRREEAAVDAQQQ 1441
Score = 33.1 bits (74), Expect = 0.92
Identities = 105/479 (21%), Positives = 180/479 (37%), Gaps = 58/479 (12%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
Y+ L E E G +L L+ E+QL E + L + L+ G
Sbjct: 388 YHPLDVEKEWG-KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG------------- 433
Query: 237 KLLLLQSQLEQ----LQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
L + QL Q LQ + L +G+ +R E+ER+ L + + L + Q
Sbjct: 434 ---LCEEQLNQADALLQSDVRLLAAGKVPQR--AGEVERD---LDKADSMIRLLFNDVQT 485
Query: 293 LKD-EMDELRQSSERAGQLEATLTSCRRR--LGELRELRRQVRQLEERNAGHAERTRQLE 349
LKD + Q R +L L + R L + Q+ + +R +LE
Sbjct: 486 LKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELE 545
Query: 350 DE-LRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
D LR L A +E + +V + +++A+ L R L + E + ER
Sbjct: 546 DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ--LGSHRGLHQSIEEFRAKIERAR 603
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAELRETLLRLQL 466
++ L A L L A L+ + + +L + + A +E + +
Sbjct: 604 SDEGQLSPATRGAYRDCLGRLDLQYAK-LLNSSKARLRSLESLHSFVAAATKELMWLNEK 662
Query: 467 ENKRLC-------RQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVED 519
E + + A +E L R LE + L+ ++ R VE
Sbjct: 663 EEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVES 722
Query: 520 LQKALQEQGGKTEDSILLKRKLEEHLQK----------LHEADLELQRKREYIEELEPPT 569
Q ALQ Q + L +E HL++ + EA+ +LQ+ +E +
Sbjct: 723 FQAALQTQWSWM---LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 779
Query: 570 DSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQ--RPAAGAPPEL 626
S+T R+E+L + Q + L + +A+ V+Q ++P+ P G P L
Sbjct: 780 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHPMRGRLPLL 837
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 96.3 bits (238), Expect = 9e-20
Identities = 127/535 (23%), Positives = 222/535 (41%), Gaps = 52/535 (9%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
LS + + Q+ + R + L +++ E AGLRE++ E ++L
Sbjct: 1335 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL--EEEAAARERAGRELQ 1392
Query: 240 LLQSQLEQL----QEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
Q+QL + +EE LE+G E R E E L + + + L + + L+
Sbjct: 1393 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1452
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGEL--RELRRQVRQLEERNAGHAE-RTRQLEDEL 352
E+D+ E+ QL +TL +R+ +L E +R +EER AE R R+
Sbjct: 1453 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA---- 1508
Query: 353 RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERD 412
RA SL LE ++ +EL+ RQ A++AE E LL+ +D
Sbjct: 1509 -RALSLTRALEEEQEAREELE--RQNRALRAEL-------------------EALLSSKD 1546
Query: 413 SLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN--LAAEILPAELRETLLRLQLENKR 470
+ ++ EL A R QA L T +++ AAE L T+ L+ +++R
Sbjct: 1547 DVGKSVHELERAC---RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1603
Query: 471 -LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
L ++ A ER+ +L + L DA R Q L +L ++E+L+ + G
Sbjct: 1604 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1663
Query: 530 KTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDA 589
E+++ RK++ +++L E + RE I + + +R++ L+ + +
Sbjct: 1664 GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS----QNRESEKRLKGLEAEVLRLQE 1719
Query: 590 DLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEK 649
+L A +R RR + R M A ++ + R+ + R+ LE + E+
Sbjct: 1720 EL-AASDRARRQAQQDRDEMAD------EVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1772
Query: 650 SRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLG 704
+S E + + + E A A+S Q RG LG
Sbjct: 1773 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1827
Score = 88.6 bits (218), Expect = 2e-17
Identities = 132/536 (24%), Positives = 216/536 (40%), Gaps = 82/536 (15%)
Query: 195 LDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFR 254
L + RQ +L Q L Q+ L+++ R GE LQ ++ QL+EE R
Sbjct: 870 LQVTRQDEVLQARAQEL-QKVQELQQQSAREVGE------------LQGRVAQLEEERAR 916
Query: 255 LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL-RQSSERAGQLEAT 313
L E CAE E L R Q L + E +A E +E RQ +L+
Sbjct: 917 LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 976
Query: 314 LTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQ 373
+ L E E RQ QLE+ + ++ E++L ++L +R+ +++
Sbjct: 977 IQELEAHL-EAEEGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1033
Query: 374 GQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR------CAQLQ 427
+ +A + E+ + L KYE+ + E L + + R+ E+L+ ++LQ
Sbjct: 1034 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1093
Query: 428 PRGLTQADPSLDPTSTPVDNLAAEI--LPAELRETLLRLQLENKRLCRQEAADRERQ--- 482
+ + Q + + L A++ EL+ L R + E + + RE Q
Sbjct: 1094 EQMVEQQQRA--------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1145
Query: 483 EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL---QKALQEQGGKTEDSILLKR 539
E Q LE AR E Q R ++L LR ++ED A QE K E + +
Sbjct: 1146 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELK 1205
Query: 540 KLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYR 599
K E ++HEA ++ R+R + + EL L++ A E
Sbjct: 1206 KTLEEETRIHEAAVQELRQRH-------------GQALGELAEQLEQARRGKGAWE---- 1248
Query: 600 RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEM----------DFEK 649
K R+ ++ + R EL SL+T +E + R R LE+ D E+
Sbjct: 1249 ----KTRLALEAEVSELR------AELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1298
Query: 650 SRS------QREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSR 699
+R+ QR Q E +S N + R +E + AQ AQ+ L +R
Sbjct: 1299 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR 1354
Score = 88.2 bits (217), Expect = 2e-17
Identities = 160/688 (23%), Positives = 269/688 (39%), Gaps = 94/688 (13%)
Query: 58 SEDPGPNWKLKVSNLKMVLRSLVEYSQDV----LAHPVSEEHLPDV-----SLIGEFSDP 108
+ED G + +L+ +L E +D+ +A +E+ D+ +L GE D
Sbjct: 1124 AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDT 1183
Query: 109 AELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYG 168
+ Q + +++Q+ + TLEE + + A+QEL
Sbjct: 1184 LDSTNAQQ-----ELRSKREQEVTELKKTLEEETR-IHEAAVQEL--------------- 1222
Query: 169 NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGE 228
+ R L E AE+ ++ ++ E+ + L E L E + L+ R EGE
Sbjct: 1223 ----RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQT--ARQEGE 1276
Query: 229 GTPGLTAKKLLLLQSQLE-QLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLA 287
+ +LE QLQE R G +L+R AEL++ + AL
Sbjct: 1277 QR-----------RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1325
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
+ L E+ A +L T + LG +VR +E AG E Q
Sbjct: 1326 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS------RVRAMEAEAAGLRE---Q 1376
Query: 348 LEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL 407
LE+E +L+ + Q+ E + +++EEA E R + E++T+
Sbjct: 1377 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1436
Query: 408 LAERDSL----REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR 463
D L R +EL A + Q +L+ D L AE A LR
Sbjct: 1437 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR----- 1491
Query: 464 LQLENKRLCRQEAADRE-RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQK 522
+E + E +RE R L R LE+ AR LE Q+R + +L L + +D+ K
Sbjct: 1492 -AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGK 1550
Query: 523 ALQE-------QGGKTEDSILLKRKLEEHLQKLHEADLELQ-----RKREYIEELEPPTD 570
++ E D +LE+ L +A L L+ K ++ +L+ +
Sbjct: 1551 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDE 1610
Query: 571 SSTARRIEELQHNLQKKDADLRAMEERYRRYVDKA--RMVMQTMEPKQRPAAGAPPELHS 628
+ RR Q Q +DA++ EER +R + A + + +E + A A
Sbjct: 1611 AGEERR---RQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1667
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQRE-------QEEKLLISAWYNMGMALQQRAGEERA 681
QLR+ +++ L + E++R+ RE + EK L + ++ A +RA
Sbjct: 1668 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1727
Query: 682 PAHAQSFLAQQRLATNSRRGPLGRLASL 709
AQ + +A G L + A L
Sbjct: 1728 RRQAQQ--DRDEMADEVANGNLSKAAIL 1753
Score = 76.6 bits (187), Expect = 7e-14
Identities = 128/499 (25%), Positives = 214/499 (42%), Gaps = 73/499 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLT-AKKL 238
L +E + EL++ L+ + L E+ Q LR ++GR E E L A+
Sbjct: 1068 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1127
Query: 239 LLLQSQ-LEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
++Q L+ L+E L +ED L + R AE Q R+ L +E +AL+ E+
Sbjct: 1128 GGARAQLLKSLREAQAALAEAQED--LESERVARTKAEKQRRD-----LGEELEALRGEL 1180
Query: 298 DELRQSSERAGQL----EATLTSCRRRLGELRELRR-QVRQLEERNA-GHAERTRQLEDE 351
++ S+ +L E +T ++ L E + V++L +R+ E QLE
Sbjct: 1181 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1240
Query: 352 LRRAG-------SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEK 404
R G +L A++ R ++ LQ RQE + + + + ++ + +
Sbjct: 1241 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR----AGDG 1296
Query: 405 ERLLAE-RDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAE---LRET 460
ER AE + L+ A EL L +A+ S + + A++ A+ ET
Sbjct: 1297 ERARAEAAEKLQRAQAELENVS---GALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1353
Query: 461 LLRLQLENK-RLCRQEAAD-RERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVE 518
+L L ++ R EAA RE+ EE E A R R G E Q Q QLSE R + E
Sbjct: 1354 RAKLALGSRVRAMEAEAAGLREQLEE-----EAAARERAGRELQ--TAQAQLSEWRRRQE 1406
Query: 519 DLQKAL------------------QEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKRE 560
+ AL Q KTE L+R Q+L +A ++L+++R+
Sbjct: 1407 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1466
Query: 561 YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVD------KARMVMQTMEP 614
+ LE R+ ++L ++K A LRA+EER R + +A + + +E
Sbjct: 1467 LVSTLE-----KKQRKFDQLL--AEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1519
Query: 615 KQRPAAGAPPELHSLRTQL 633
+Q + +LR +L
Sbjct: 1520 EQEAREELERQNRALRAEL 1538
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/490 (23%), Positives = 204/490 (41%), Gaps = 73/490 (14%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
EKKQ +++ E++ V+ A++E ++ ++ E S +R L EE E
Sbjct: 1472 EKKQRKFDQLLAEEKAA---VLRAVEE---RERAEAEGREREARALSLTRA---LEEEQE 1522
Query: 186 EGDEL--QQRCLDLERQLMLLSE----------EKQSLAQENAG--LRERMGRPEGEGTP 231
+EL Q R L E + +L S+ E+ E A LR ++ E E T
Sbjct: 1523 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1582
Query: 232 GLTAKKLLLLQSQLEQLQEENF---RLESGREDER-----LRCAELEREVAELQHRNQAL 283
AK L + Q + Q E R E+G E R LR AE+ER+ + R Q
Sbjct: 1583 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD----EERKQRT 1638
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQ-LEATLTSCRRRLGELRELRRQVRQLE------- 335
++A + L+ E++EL+ AGQ E + R+ +++EL R+V +
Sbjct: 1639 LAVAARKK-LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF 1697
Query: 336 ERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEE 395
+N +R + LE E+ R A + RRQ Q+ + + +E L + LEE
Sbjct: 1698 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN--LSKAAILEE 1755
Query: 396 KYE---SVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN----- 447
K + + + +E L E+ + N+ R LQ LT + S ++
Sbjct: 1756 KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1815
Query: 448 ----------LAAEILPAELRETLLRLQLENKRLCRQEAADRERQEEL------QRHLED 491
L E A R + LE+K +E ++E +E + +R +
Sbjct: 1816 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1875
Query: 492 ANRARHGLETQHRLNQQ---QLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKL 548
+E + R+ Q QL + +V+ L++ L+E + + +R+L+ L+ +
Sbjct: 1876 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1935
Query: 549 HEADLELQRK 558
E+ + R+
Sbjct: 1936 TESAESMNRE 1945
Score = 54.3 bits (129), Expect = 4e-07
Identities = 73/322 (22%), Positives = 142/322 (44%), Gaps = 38/322 (11%)
Query: 112 GKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFD 171
G+L +L A + + K++ ++++ ++ ++ + E + +++ S + E+
Sbjct: 1649 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1708
Query: 172 SQSRRYYFLSEEAEEGD----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
L EE D + QQ ++ ++ + K ++ +E L R+G+ E
Sbjct: 1709 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1768
Query: 228 EGTPGLTAKKLL-----LLQSQLEQLQEE-------NFRLESGREDERLRCAELEREVAE 275
E + +LL L Q+E L E + + ESGR+ +LER++ E
Sbjct: 1769 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQ-------QLERQIQE 1821
Query: 276 LQHR--NQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQ 333
L+ R + + A+ + +L Q+ E+ Q R R+ + +RR ++
Sbjct: 1822 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ------ETRERILSGKLVRRAEKR 1875
Query: 334 LEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNL 393
L+E Q+E+E R A LR QLE +V++L+ Q +E +A + R L
Sbjct: 1876 LKEV-------VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1928
Query: 394 EEKYESVTKEKERLLAERDSLR 415
+ + E VT+ E + E +LR
Sbjct: 1929 QRELEDVTESAESMNREVTTLR 1950
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 96.3 bits (238), Expect = 9e-20
Identities = 127/535 (23%), Positives = 222/535 (41%), Gaps = 52/535 (9%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
LS + + Q+ + R + L +++ E AGLRE++ E ++L
Sbjct: 1327 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL--EEEAAARERAGRELQ 1384
Query: 240 LLQSQLEQL----QEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
Q+QL + +EE LE+G E R E E L + + + L + + L+
Sbjct: 1385 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1444
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGEL--RELRRQVRQLEERNAGHAE-RTRQLEDEL 352
E+D+ E+ QL +TL +R+ +L E +R +EER AE R R+
Sbjct: 1445 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA---- 1500
Query: 353 RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERD 412
RA SL LE ++ +EL+ RQ A++AE E LL+ +D
Sbjct: 1501 -RALSLTRALEEEQEAREELE--RQNRALRAEL-------------------EALLSSKD 1538
Query: 413 SLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN--LAAEILPAELRETLLRLQLENKR 470
+ ++ EL A R QA L T +++ AAE L T+ L+ +++R
Sbjct: 1539 DVGKSVHELERAC---RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1595
Query: 471 -LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
L ++ A ER+ +L + L DA R Q L +L ++E+L+ + G
Sbjct: 1596 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1655
Query: 530 KTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDA 589
E+++ RK++ +++L E + RE I + + +R++ L+ + +
Sbjct: 1656 GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS----QNRESEKRLKGLEAEVLRLQE 1711
Query: 590 DLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEK 649
+L A +R RR + R M A ++ + R+ + R+ LE + E+
Sbjct: 1712 EL-AASDRARRQAQQDRDEMAD------EVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1764
Query: 650 SRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLG 704
+S E + + + E A A+S Q RG LG
Sbjct: 1765 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1819
Score = 88.6 bits (218), Expect = 2e-17
Identities = 132/536 (24%), Positives = 216/536 (40%), Gaps = 82/536 (15%)
Query: 195 LDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFR 254
L + RQ +L Q L Q+ L+++ R GE LQ ++ QL+EE R
Sbjct: 862 LQVTRQDEVLQARAQEL-QKVQELQQQSAREVGE------------LQGRVAQLEEERAR 908
Query: 255 LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL-RQSSERAGQLEAT 313
L E CAE E L R Q L + E +A E +E RQ +L+
Sbjct: 909 LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 968
Query: 314 LTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQ 373
+ L E E RQ QLE+ + ++ E++L ++L +R+ +++
Sbjct: 969 IQELEAHL-EAEEGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1025
Query: 374 GQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR------CAQLQ 427
+ +A + E+ + L KYE+ + E L + + R+ E+L+ ++LQ
Sbjct: 1026 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1085
Query: 428 PRGLTQADPSLDPTSTPVDNLAAEI--LPAELRETLLRLQLENKRLCRQEAADRERQ--- 482
+ + Q + + L A++ EL+ L R + E + + RE Q
Sbjct: 1086 EQMVEQQQRA--------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1137
Query: 483 EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL---QKALQEQGGKTEDSILLKR 539
E Q LE AR E Q R ++L LR ++ED A QE K E + +
Sbjct: 1138 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELK 1197
Query: 540 KLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYR 599
K E ++HEA ++ R+R + + EL L++ A E
Sbjct: 1198 KTLEEETRIHEAAVQELRQRH-------------GQALGELAEQLEQARRGKGAWE---- 1240
Query: 600 RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEM----------DFEK 649
K R+ ++ + R EL SL+T +E + R R LE+ D E+
Sbjct: 1241 ----KTRLALEAEVSELR------AELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1290
Query: 650 SRS------QREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSR 699
+R+ QR Q E +S N + R +E + AQ AQ+ L +R
Sbjct: 1291 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR 1346
Score = 88.2 bits (217), Expect = 2e-17
Identities = 160/688 (23%), Positives = 269/688 (39%), Gaps = 94/688 (13%)
Query: 58 SEDPGPNWKLKVSNLKMVLRSLVEYSQDV----LAHPVSEEHLPDV-----SLIGEFSDP 108
+ED G + +L+ +L E +D+ +A +E+ D+ +L GE D
Sbjct: 1116 AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDT 1175
Query: 109 AELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYG 168
+ Q + +++Q+ + TLEE + + A+QEL
Sbjct: 1176 LDSTNAQQ-----ELRSKREQEVTELKKTLEEETR-IHEAAVQEL--------------- 1214
Query: 169 NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGE 228
+ R L E AE+ ++ ++ E+ + L E L E + L+ R EGE
Sbjct: 1215 ----RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQT--ARQEGE 1268
Query: 229 GTPGLTAKKLLLLQSQLE-QLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLA 287
+ +LE QLQE R G +L+R AEL++ + AL
Sbjct: 1269 QR-----------RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1317
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
+ L E+ A +L T + LG +VR +E AG E Q
Sbjct: 1318 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS------RVRAMEAEAAGLRE---Q 1368
Query: 348 LEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL 407
LE+E +L+ + Q+ E + +++EEA E R + E++T+
Sbjct: 1369 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1428
Query: 408 LAERDSL----REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR 463
D L R +EL A + Q +L+ D L AE A LR
Sbjct: 1429 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR----- 1483
Query: 464 LQLENKRLCRQEAADRE-RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQK 522
+E + E +RE R L R LE+ AR LE Q+R + +L L + +D+ K
Sbjct: 1484 -AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGK 1542
Query: 523 ALQE-------QGGKTEDSILLKRKLEEHLQKLHEADLELQ-----RKREYIEELEPPTD 570
++ E D +LE+ L +A L L+ K ++ +L+ +
Sbjct: 1543 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDE 1602
Query: 571 SSTARRIEELQHNLQKKDADLRAMEERYRRYVDKA--RMVMQTMEPKQRPAAGAPPELHS 628
+ RR Q Q +DA++ EER +R + A + + +E + A A
Sbjct: 1603 AGEERR---RQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1659
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQRE-------QEEKLLISAWYNMGMALQQRAGEERA 681
QLR+ +++ L + E++R+ RE + EK L + ++ A +RA
Sbjct: 1660 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1719
Query: 682 PAHAQSFLAQQRLATNSRRGPLGRLASL 709
AQ + +A G L + A L
Sbjct: 1720 RRQAQQ--DRDEMADEVANGNLSKAAIL 1745
Score = 76.6 bits (187), Expect = 7e-14
Identities = 128/499 (25%), Positives = 214/499 (42%), Gaps = 73/499 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLT-AKKL 238
L +E + EL++ L+ + L E+ Q LR ++GR E E L A+
Sbjct: 1060 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1119
Query: 239 LLLQSQ-LEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
++Q L+ L+E L +ED L + R AE Q R+ L +E +AL+ E+
Sbjct: 1120 GGARAQLLKSLREAQAALAEAQED--LESERVARTKAEKQRRD-----LGEELEALRGEL 1172
Query: 298 DELRQSSERAGQL----EATLTSCRRRLGELRELRR-QVRQLEERNA-GHAERTRQLEDE 351
++ S+ +L E +T ++ L E + V++L +R+ E QLE
Sbjct: 1173 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1232
Query: 352 LRRAG-------SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEK 404
R G +L A++ R ++ LQ RQE + + + + ++ + +
Sbjct: 1233 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR----AGDG 1288
Query: 405 ERLLAE-RDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAE---LRET 460
ER AE + L+ A EL L +A+ S + + A++ A+ ET
Sbjct: 1289 ERARAEAAEKLQRAQAELENVS---GALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1345
Query: 461 LLRLQLENK-RLCRQEAAD-RERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVE 518
+L L ++ R EAA RE+ EE E A R R G E Q Q QLSE R + E
Sbjct: 1346 RAKLALGSRVRAMEAEAAGLREQLEE-----EAAARERAGRELQ--TAQAQLSEWRRRQE 1398
Query: 519 DLQKAL------------------QEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKRE 560
+ AL Q KTE L+R Q+L +A ++L+++R+
Sbjct: 1399 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1458
Query: 561 YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVD------KARMVMQTMEP 614
+ LE R+ ++L ++K A LRA+EER R + +A + + +E
Sbjct: 1459 LVSTLE-----KKQRKFDQLL--AEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1511
Query: 615 KQRPAAGAPPELHSLRTQL 633
+Q + +LR +L
Sbjct: 1512 EQEAREELERQNRALRAEL 1530
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/490 (23%), Positives = 204/490 (41%), Gaps = 73/490 (14%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
EKKQ +++ E++ V+ A++E ++ ++ E S +R L EE E
Sbjct: 1464 EKKQRKFDQLLAEEKAA---VLRAVEE---RERAEAEGREREARALSLTRA---LEEEQE 1514
Query: 186 EGDEL--QQRCLDLERQLMLLSE----------EKQSLAQENAG--LRERMGRPEGEGTP 231
+EL Q R L E + +L S+ E+ E A LR ++ E E T
Sbjct: 1515 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1574
Query: 232 GLTAKKLLLLQSQLEQLQEENF---RLESGREDER-----LRCAELEREVAELQHRNQAL 283
AK L + Q + Q E R E+G E R LR AE+ER+ + R Q
Sbjct: 1575 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD----EERKQRT 1630
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQ-LEATLTSCRRRLGELRELRRQVRQLE------- 335
++A + L+ E++EL+ AGQ E + R+ +++EL R+V +
Sbjct: 1631 LAVAARKK-LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF 1689
Query: 336 ERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEE 395
+N +R + LE E+ R A + RRQ Q+ + + +E L + LEE
Sbjct: 1690 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN--LSKAAILEE 1747
Query: 396 KYE---SVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN----- 447
K + + + +E L E+ + N+ R LQ LT + S ++
Sbjct: 1748 KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1807
Query: 448 ----------LAAEILPAELRETLLRLQLENKRLCRQEAADRERQEEL------QRHLED 491
L E A R + LE+K +E ++E +E + +R +
Sbjct: 1808 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1867
Query: 492 ANRARHGLETQHRLNQQ---QLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKL 548
+E + R+ Q QL + +V+ L++ L+E + + +R+L+ L+ +
Sbjct: 1868 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1927
Query: 549 HEADLELQRK 558
E+ + R+
Sbjct: 1928 TESAESMNRE 1937
Score = 54.3 bits (129), Expect = 4e-07
Identities = 73/322 (22%), Positives = 142/322 (44%), Gaps = 38/322 (11%)
Query: 112 GKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFD 171
G+L +L A + + K++ ++++ ++ ++ + E + +++ S + E+
Sbjct: 1641 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1700
Query: 172 SQSRRYYFLSEEAEEGD----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
L EE D + QQ ++ ++ + K ++ +E L R+G+ E
Sbjct: 1701 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1760
Query: 228 EGTPGLTAKKLL-----LLQSQLEQLQEE-------NFRLESGREDERLRCAELEREVAE 275
E + +LL L Q+E L E + + ESGR+ +LER++ E
Sbjct: 1761 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQ-------QLERQIQE 1813
Query: 276 LQHR--NQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQ 333
L+ R + + A+ + +L Q+ E+ Q R R+ + +RR ++
Sbjct: 1814 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ------ETRERILSGKLVRRAEKR 1867
Query: 334 LEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNL 393
L+E Q+E+E R A LR QLE +V++L+ Q +E +A + R L
Sbjct: 1868 LKEV-------VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1920
Query: 394 EEKYESVTKEKERLLAERDSLR 415
+ + E VT+ E + E +LR
Sbjct: 1921 QRELEDVTESAESMNREVTTLR 1942
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 96.3 bits (238), Expect = 9e-20
Identities = 127/535 (23%), Positives = 222/535 (41%), Gaps = 52/535 (9%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
LS + + Q+ + R + L +++ E AGLRE++ E ++L
Sbjct: 1368 LSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQL--EEEAAARERAGRELQ 1425
Query: 240 LLQSQLEQL----QEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
Q+QL + +EE LE+G E R E E L + + + L + + L+
Sbjct: 1426 TAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ 1485
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGEL--RELRRQVRQLEERNAGHAE-RTRQLEDEL 352
E+D+ E+ QL +TL +R+ +L E +R +EER AE R R+
Sbjct: 1486 ELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA---- 1541
Query: 353 RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERD 412
RA SL LE ++ +EL+ RQ A++AE E LL+ +D
Sbjct: 1542 -RALSLTRALEEEQEAREELE--RQNRALRAEL-------------------EALLSSKD 1579
Query: 413 SLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN--LAAEILPAELRETLLRLQLENKR 470
+ ++ EL A R QA L T +++ AAE L T+ L+ +++R
Sbjct: 1580 DVGKSVHELERAC---RVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1636
Query: 471 -LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
L ++ A ER+ +L + L DA R Q L +L ++E+L+ + G
Sbjct: 1637 DLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQ 1696
Query: 530 KTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDA 589
E+++ RK++ +++L E + RE I + + +R++ L+ + +
Sbjct: 1697 GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFS----QNRESEKRLKGLEAEVLRLQE 1752
Query: 590 DLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEK 649
+L A +R RR + R M A ++ + R+ + R+ LE + E+
Sbjct: 1753 EL-AASDRARRQAQQDRDEMAD------EVANGNLSKAAILEEKRQLEGRLGQLEEELEE 1805
Query: 650 SRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRRGPLG 704
+S E + + + E A A+S Q RG LG
Sbjct: 1806 EQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLG 1860
Score = 88.6 bits (218), Expect = 2e-17
Identities = 132/536 (24%), Positives = 216/536 (40%), Gaps = 82/536 (15%)
Query: 195 LDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFR 254
L + RQ +L Q L Q+ L+++ R GE LQ ++ QL+EE R
Sbjct: 903 LQVTRQDEVLQARAQEL-QKVQELQQQSAREVGE------------LQGRVAQLEEERAR 949
Query: 255 LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL-RQSSERAGQLEAT 313
L E CAE E L R Q L + E +A E +E RQ +L+
Sbjct: 950 LAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQH 1009
Query: 314 LTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQ 373
+ L E E RQ QLE+ + ++ E++L ++L +R+ +++
Sbjct: 1010 IQELEAHL-EAEEGARQKLQLEKVTT--EAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL 1066
Query: 374 GQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR------CAQLQ 427
+ +A + E+ + L KYE+ + E L + + R+ E+L+ ++LQ
Sbjct: 1067 AEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQ 1126
Query: 428 PRGLTQADPSLDPTSTPVDNLAAEI--LPAELRETLLRLQLENKRLCRQEAADRERQ--- 482
+ + Q + + L A++ EL+ L R + E + + RE Q
Sbjct: 1127 EQMVEQQQRA--------EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAAL 1178
Query: 483 EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL---QKALQEQGGKTEDSILLKR 539
E Q LE AR E Q R ++L LR ++ED A QE K E + +
Sbjct: 1179 AEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELK 1238
Query: 540 KLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYR 599
K E ++HEA ++ R+R + + EL L++ A E
Sbjct: 1239 KTLEEETRIHEAAVQELRQRH-------------GQALGELAEQLEQARRGKGAWE---- 1281
Query: 600 RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEM----------DFEK 649
K R+ ++ + R EL SL+T +E + R R LE+ D E+
Sbjct: 1282 ----KTRLALEAEVSELR------AELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGER 1331
Query: 650 SRS------QREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSR 699
+R+ QR Q E +S N + R +E + AQ AQ+ L +R
Sbjct: 1332 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETR 1387
Score = 88.2 bits (217), Expect = 2e-17
Identities = 160/688 (23%), Positives = 269/688 (39%), Gaps = 94/688 (13%)
Query: 58 SEDPGPNWKLKVSNLKMVLRSLVEYSQDV----LAHPVSEEHLPDV-----SLIGEFSDP 108
+ED G + +L+ +L E +D+ +A +E+ D+ +L GE D
Sbjct: 1157 AEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDT 1216
Query: 109 AELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYG 168
+ Q + +++Q+ + TLEE + + A+QEL
Sbjct: 1217 LDSTNAQQ-----ELRSKREQEVTELKKTLEEETR-IHEAAVQEL--------------- 1255
Query: 169 NFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGE 228
+ R L E AE+ ++ ++ E+ + L E L E + L+ R EGE
Sbjct: 1256 ----RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQT--ARQEGE 1309
Query: 229 GTPGLTAKKLLLLQSQLE-QLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLA 287
+ +LE QLQE R G +L+R AEL++ + AL
Sbjct: 1310 QR-----------RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAE 1358
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
+ L E+ A +L T + LG +VR +E AG E Q
Sbjct: 1359 SKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGS------RVRAMEAEAAGLRE---Q 1409
Query: 348 LEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL 407
LE+E +L+ + Q+ E + +++EEA E R + E++T+
Sbjct: 1410 LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEK 1469
Query: 408 LAERDSL----REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR 463
D L R +EL A + Q +L+ D L AE A LR
Sbjct: 1470 TETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLR----- 1524
Query: 464 LQLENKRLCRQEAADRE-RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQK 522
+E + E +RE R L R LE+ AR LE Q+R + +L L + +D+ K
Sbjct: 1525 -AVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGK 1583
Query: 523 ALQE-------QGGKTEDSILLKRKLEEHLQKLHEADLELQ-----RKREYIEELEPPTD 570
++ E D +LE+ L +A L L+ K ++ +L+ +
Sbjct: 1584 SVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDE 1643
Query: 571 SSTARRIEELQHNLQKKDADLRAMEERYRRYVDKA--RMVMQTMEPKQRPAAGAPPELHS 628
+ RR Q Q +DA++ EER +R + A + + +E + A A
Sbjct: 1644 AGEERR---RQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEE 1700
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQRE-------QEEKLLISAWYNMGMALQQRAGEERA 681
QLR+ +++ L + E++R+ RE + EK L + ++ A +RA
Sbjct: 1701 AVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRA 1760
Query: 682 PAHAQSFLAQQRLATNSRRGPLGRLASL 709
AQ + +A G L + A L
Sbjct: 1761 RRQAQQ--DRDEMADEVANGNLSKAAIL 1786
Score = 76.6 bits (187), Expect = 7e-14
Identities = 128/499 (25%), Positives = 214/499 (42%), Gaps = 73/499 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLT-AKKL 238
L +E + EL++ L+ + L E+ Q LR ++GR E E L A+
Sbjct: 1101 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE 1160
Query: 239 LLLQSQ-LEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM 297
++Q L+ L+E L +ED L + R AE Q R+ L +E +AL+ E+
Sbjct: 1161 GGARAQLLKSLREAQAALAEAQED--LESERVARTKAEKQRRD-----LGEELEALRGEL 1213
Query: 298 DELRQSSERAGQL----EATLTSCRRRLGELRELRR-QVRQLEERNA-GHAERTRQLEDE 351
++ S+ +L E +T ++ L E + V++L +R+ E QLE
Sbjct: 1214 EDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQA 1273
Query: 352 LRRAG-------SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEK 404
R G +L A++ R ++ LQ RQE + + + + ++ + +
Sbjct: 1274 RRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR----AGDG 1329
Query: 405 ERLLAE-RDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAE---LRET 460
ER AE + L+ A EL L +A+ S + + A++ A+ ET
Sbjct: 1330 ERARAEAAEKLQRAQAELENVS---GALNEAESKTIRLSKELSSTEAQLHDAQELLQEET 1386
Query: 461 LLRLQLENK-RLCRQEAAD-RERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVE 518
+L L ++ R EAA RE+ EE E A R R G E Q Q QLSE R + E
Sbjct: 1387 RAKLALGSRVRAMEAEAAGLREQLEE-----EAAARERAGRELQ--TAQAQLSEWRRRQE 1439
Query: 519 DLQKAL------------------QEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKRE 560
+ AL Q KTE L+R Q+L +A ++L+++R+
Sbjct: 1440 EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQ 1499
Query: 561 YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVD------KARMVMQTMEP 614
+ LE R+ ++L ++K A LRA+EER R + +A + + +E
Sbjct: 1500 LVSTLE-----KKQRKFDQLL--AEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1552
Query: 615 KQRPAAGAPPELHSLRTQL 633
+Q + +LR +L
Sbjct: 1553 EQEAREELERQNRALRAEL 1571
Score = 65.1 bits (157), Expect = 2e-10
Identities = 116/490 (23%), Positives = 204/490 (41%), Gaps = 73/490 (14%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
EKKQ +++ E++ V+ A++E ++ ++ E S +R L EE E
Sbjct: 1505 EKKQRKFDQLLAEEKAA---VLRAVEE---RERAEAEGREREARALSLTRA---LEEEQE 1555
Query: 186 EGDEL--QQRCLDLERQLMLLSE----------EKQSLAQENAG--LRERMGRPEGEGTP 231
+EL Q R L E + +L S+ E+ E A LR ++ E E T
Sbjct: 1556 AREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1615
Query: 232 GLTAKKLLLLQSQLEQLQEENF---RLESGREDER-----LRCAELEREVAELQHRNQAL 283
AK L + Q + Q E R E+G E R LR AE+ER+ + R Q
Sbjct: 1616 AEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERD----EERKQRT 1671
Query: 284 TSLAQEAQALKDEMDELRQSSERAGQ-LEATLTSCRRRLGELRELRRQVRQLE------- 335
++A + L+ E++EL+ AGQ E + R+ +++EL R+V +
Sbjct: 1672 LAVAARKK-LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIF 1730
Query: 336 ERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEE 395
+N +R + LE E+ R A + RRQ Q+ + + +E L + LEE
Sbjct: 1731 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGN--LSKAAILEE 1788
Query: 396 KYE---SVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDN----- 447
K + + + +E L E+ + N+ R LQ LT + S ++
Sbjct: 1789 KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL 1848
Query: 448 ----------LAAEILPAELRETLLRLQLENKRLCRQEAADRERQEEL------QRHLED 491
L E A R + LE+K +E ++E +E + +R +
Sbjct: 1849 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1908
Query: 492 ANRARHGLETQHRLNQQ---QLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKL 548
+E + R+ Q QL + +V+ L++ L+E + + +R+L+ L+ +
Sbjct: 1909 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1968
Query: 549 HEADLELQRK 558
E+ + R+
Sbjct: 1969 TESAESMNRE 1978
Score = 54.3 bits (129), Expect = 4e-07
Identities = 73/322 (22%), Positives = 142/322 (44%), Gaps = 38/322 (11%)
Query: 112 GKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFD 171
G+L +L A + + K++ ++++ ++ ++ + E + +++ S + E+
Sbjct: 1682 GELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLK 1741
Query: 172 SQSRRYYFLSEEAEEGD----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
L EE D + QQ ++ ++ + K ++ +E L R+G+ E
Sbjct: 1742 GLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEE 1801
Query: 228 EGTPGLTAKKLL-----LLQSQLEQLQEE-------NFRLESGREDERLRCAELEREVAE 275
E + +LL L Q+E L E + + ESGR+ +LER++ E
Sbjct: 1802 ELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQ-------QLERQIQE 1854
Query: 276 LQHR--NQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQ 333
L+ R + + A+ + +L Q+ E+ Q R R+ + +RR ++
Sbjct: 1855 LRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ------ETRERILSGKLVRRAEKR 1908
Query: 334 LEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNL 393
L+E Q+E+E R A LR QLE +V++L+ Q +E +A + R L
Sbjct: 1909 LKEV-------VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRL 1961
Query: 394 EEKYESVTKEKERLLAERDSLR 415
+ + E VT+ E + E +LR
Sbjct: 1962 QRELEDVTESAESMNREVTTLR 1983
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 95.1 bits (235), Expect = 2e-19
Identities = 124/512 (24%), Positives = 242/512 (47%), Gaps = 63/512 (12%)
Query: 172 SQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTP 231
S R + LSE+ E +L++ ++E + L E + L Q+ +E+ G
Sbjct: 359 SLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE-KEQHGLQLQSEIN 417
Query: 232 GLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQE-- 289
L +K LL+++ QL E + RL+ R+ + + E++VA+LQ + L +E
Sbjct: 418 QLHSK---LLETE-RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
Query: 290 --AQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
+ L+ ++D+ +Q + L+ + T+ +LRE + + Q+ RQ
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTA------KLREAQNDLEQV----------LRQ 517
Query: 348 LEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFEC---RNLEEK----YESV 400
+ D+ ++ +L A L+ + + L+ +R++ K + E L+EK E V
Sbjct: 518 IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 401 TKEKERLLAERDSLREANEELRC-AQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRE 459
T+ E+L + +S ++A E L Q Q L A + T V+ L +++ ++ +
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 460 TLLRLQLENKR--LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQV 517
+ L +Q++ K L EAA ++ +LQ HL+ A A QQ+L+++ Q+
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD-------KQQELNKITTQL 690
Query: 518 EDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE----ELEPPT---D 570
+ + LQ+ K E +LE HL++ E L L++K E +E +LE +
Sbjct: 691 DQVTAKLQD---KQEHC----SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK 743
Query: 571 SSTARRIEELQHNLQ-KKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 629
+S + +++LQ Q D +LRA E + ++K + ++ +++ A L S+
Sbjct: 744 ASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA-----LESI 798
Query: 630 RTQLRERDVRIRHLEMDFEK-SRSQREQEEKL 660
+ +L +++ + L+ DFE S+ + Q E+L
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830
Score = 87.4 bits (215), Expect = 4e-17
Identities = 120/500 (24%), Positives = 223/500 (44%), Gaps = 73/500 (14%)
Query: 190 LQQRCLDLERQLM---LLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLE 246
L+Q DL+ L SEE + ++ GL+++ +P+G T ++ +L L+ QLE
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTD--SSAELQSLEQQLE 145
Query: 247 QLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSER 306
+ Q ENF ++ ++ + A+L E+A+++ + SL + A+ + E + ++
Sbjct: 146 EAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTE--ELNKE 203
Query: 307 AGQLEATLTSCRRRLG-----ELRELRRQVRQLEERNAGHAER-TRQLEDELRRAGSLRA 360
A ++ T +R G L++ QV+ L + ER + +L+DE ++ S A
Sbjct: 204 ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
Query: 361 QLEAQRRQ---------------VQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKE 405
EA Q VQELQ + +K NL +K + TK +E
Sbjct: 264 SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
Query: 406 RLLAERDSLREA-----NEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRET 460
+ E S + ++L C QLQ R L + T + + E+ +E E
Sbjct: 324 KHNEESVSKKNIQATLHQKDLDCQQLQSR--------LSASETSLHRIHVEL--SEKGEA 373
Query: 461 LLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDL 520
+L+ E + + + ++LQ+ E+ + +HGL+ Q +NQ L +++ +
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREE--KEQHGLQLQSEINQ-----LHSKLLET 426
Query: 521 QKALQEQGGK-TEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEE 579
++ L E G+ E L KL + Q++ + L+L R E ++ E T+S+ E
Sbjct: 427 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK--EKVTNST------E 478
Query: 580 LQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVR 639
LQH L K ++ + + + Q+ K R A +L + Q+ ++D +
Sbjct: 479 LQHQLDKT-----------KQQHQEQQALQQSTTAKLREAQN---DLEQVLRQIGDKDQK 524
Query: 640 IRHLEMDFEKSRSQREQEEK 659
I++LE +KS+ EK
Sbjct: 525 IQNLEALLQKSKENISLLEK 544
Score = 72.4 bits (176), Expect = 1e-12
Identities = 101/540 (18%), Positives = 231/540 (42%), Gaps = 57/540 (10%)
Query: 173 QSRRYYFLSEEAEEGD-----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEG 227
+ R + +A EG+ +LQ++ L+ Q+ L+E+ ++ ++ + +E +
Sbjct: 544 KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
Query: 228 EGTPGLTAK--KLLLLQSQLEQLQEENFRLESGRE-----DERLRCAE---LEREVAELQ 277
E L A ++L L++ + +L N +L +E D +++ L E A+
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNEL---NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 660
Query: 278 HRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEER 337
R L AL+D+ EL + + + Q+ A L + +L +++ +E+
Sbjct: 661 QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES---HLKEYKEK 717
Query: 338 NAGHAERTRQLEDELRRAGSLRAQLEAQRRQ-VQELQGQRQEEAMKAEKWLFECRNLEEK 396
++T +LE ++++ + +++A + Q +Q+LQ QRQ + + LE +
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 397 YESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSL--------DPTSTPVDNL 448
E V+ + L + ++L ++L + + + L Q +L + + +
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 449 AAEILPAELRETLLRLQLENKRLCRQEAAD--RERQEELQRHLEDANRA----------- 495
E+ ++ + L +L + + +D + + E ++ + A
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 496 RHGLETQHRLNQQQLSELRAQVEDLQKA----------LQEQGGKTEDSILLKRKLEEHL 545
+H L+ Q ++ EL+ +E ++A +QEQ + ++++ K E+ L
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 546 Q-KLHEADLELQRKREYIEELEPPTDSSTARRIE---ELQHNLQKKDADLRAMEERYRRY 601
Q ++E ++K++ IE L+ + ++ E +LQ L + +L A +E+
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 602 VDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLL 661
+ +T + Q G EL + R L+ + ++ + D +R+Q + KL+
Sbjct: 1018 QNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLI 1077
Score = 69.7 bits (169), Expect = 9e-12
Identities = 123/557 (22%), Positives = 232/557 (41%), Gaps = 78/557 (14%)
Query: 104 EFSDPAELGKLLQLVLGCAISCEKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLS 163
E S E+ K ++V + +KK + LE Q + + ++ + K ++LS
Sbjct: 769 ELSKQLEMEK--EIVSSTRLDLQKKSE------ALESIKQKLTKQEEEKQILKQDFETLS 820
Query: 164 PETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMG 223
ET + + R E LQ+ ++ E + LS K L++ + L+
Sbjct: 821 QETKIQHEELNNRIQTTVTE------LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKS 874
Query: 224 RPEGEGTPGL--------TAKKLL-LLQSQLEQLQEENFRLESGREDERLRCAELEREVA 274
E E G T K+L LQ Q+E +E L+ E E+ +L+ E+
Sbjct: 875 EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 934
Query: 275 ELQHRN-QALTSLAQ---EAQALKDEMDELRQSSE-RAGQLEATLTSCRRRLGELRELRR 329
+Q + QA +L Q E Q L+ ++EL+QSSE + Q+EA + + + EL
Sbjct: 935 SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
Query: 330 QVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQ---RQEEAMKAEKW 386
+++Q + A ++L E + L+ E + ++LQ R+ E + +
Sbjct: 995 KLQQQLTQAA------QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ- 1047
Query: 387 LFECRNLEEKYESVTKEKERLLAERDSLREAN---EELRCAQLQ-PRGLTQADPSLDPTS 442
+ +++EEK ++ +E L++ R+ + N +EL+ A+ + + + L
Sbjct: 1048 --DLKSVEEK---LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
Query: 443 TPVDNLAAE--ILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLE 500
+ ++ E + EL +L + CRQE + EEL+ H ++ + L+
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 501 TQHRLNQQQLSELRAQVEDL----------QKALQEQGGKTEDSILLKRKLEEHLQKLHE 550
+L QQ EL+ + + L Q+ L++Q K E+ LK++ E KLH
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE--LKKEFIEKEAKLHS 1220
Query: 551 ADLELQRKREYIEELEPPTD-----------------SSTARRIEELQHNLQKKDADLRA 593
E + + EE E S+ RR+ EL+ ++
Sbjct: 1221 EIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV 1280
Query: 594 MEERYRRYVDKARMVMQ 610
+E + D+ R +++
Sbjct: 1281 LEATVQNNQDERRALLE 1297
Score = 63.5 bits (153), Expect = 6e-10
Identities = 119/506 (23%), Positives = 220/506 (43%), Gaps = 75/506 (14%)
Query: 123 ISCEKKQDHIQ---RIMTLEESVQHVVMEAIQELMTK--DTPDSLSPETYGNFDSQSRRY 177
+S E K H + RI T +Q V ME + LMT+ D LS + +S+S
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEK-EALMTELSTVKDKLSKVSDSLKNSKSE-- 875
Query: 178 YFLSEEAEEGD----ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGL 233
+E ++G +L++ C +L+ QL + E +E E+ + L
Sbjct: 876 --FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLEL 933
Query: 234 TAKKLLLLQSQ--LEQLQEENFRLE---------SGREDERLRCAELEREVAELQHRN-- 280
+ + L+Q+Q L+Q ++E +L+ S ++ +++ + E ++A LQ
Sbjct: 934 NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
Query: 281 ----QALTSLAQEAQALKDEMDELRQSSERAGQLEATLTS-CRRRLGELRELRRQVRQLE 335
Q LT AQE A K+++ L+ + E++ + L S R EL R+ ++ +E
Sbjct: 994 NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE 1053
Query: 336 ER----------NAGHAERTRQLEDELRRAGSLRAQLEAQR-RQVQE----LQGQRQEEA 380
E+ N +L EL+ A + Q A++ +Q+QE LQ ++E++
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113
Query: 381 MKAEKWLFECRNLEEKYE-------SVTKEKERLLAER-DSLREANEELRCAQLQPRGLT 432
+K ++ + E L E E +TK E L + + +S++E QL +
Sbjct: 1114 LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173
Query: 433 QADPSLDPTSTPVDNLAA--EILPAELR---ETLLRLQLENKRLCRQEAADRE------- 480
+ D V+ +IL +++ E L + +E + E ++E
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 481 -RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQE-----QGGKTEDS 534
+ +L + N ++ + + +Q+++SEL Q +DL+ + Q + E
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293
Query: 535 ILLKRKL--EEHLQKLHEADLELQRK 558
LL+R L E ++KL LELQRK
Sbjct: 1294 ALLERCLKGEGEIEKLQTKVLELQRK 1319
Score = 42.0 bits (97), Expect = 0.002
Identities = 42/159 (26%), Positives = 81/159 (50%), Gaps = 22/159 (13%)
Query: 471 LCRQEAADRERQEELQRHLE---DA-NRARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+C Q +EL +H E DA N + HG E+ L + ++ LR +V+DLQ +L+E
Sbjct: 42 ICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKE 101
Query: 527 QGGKTEDSILLKRKLEEH--LQK--------LHEADLELQRKREYIEELEPPTDSSTARR 576
+ +E+ LK++LE++ LQ+ + ++ ELQ + +EE + T++ ++
Sbjct: 102 EKWYSEE---LKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQ--TENFNIKQ 156
Query: 577 IEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPK 615
+++L ++K A L + D+ R + + E K
Sbjct: 157 MKDL---FEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 91.7 bits (226), Expect = 2e-18
Identities = 137/590 (23%), Positives = 233/590 (39%), Gaps = 99/590 (16%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
+E ++LQ+ + +RQ L EE+Q E LR E + ++ L + Q
Sbjct: 255 KEEEKLQEE--EPQRQRELQEEEEQLRKLERQELRRERQEEEQQ-------QQRLRREQQ 305
Query: 245 LEQLQEENFR--LESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ 302
L + QEE R E RE + R + ER +L+ + +E Q +++ +E R+
Sbjct: 306 LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE----RREQQLRREQEEERRE 361
Query: 303 SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQL--------EDELRR 354
R Q E RR +LR ++ R+ + R R +QL E +LRR
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSL 414
LR + E +R + + Q +R++ + ++ + EE+ E +E+ + +RD
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 415 REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ 474
E E + + R Q E RE LR + E +R Q
Sbjct: 482 EERRERWLKLEEEERREQQ----------------------ERREQQLRREQEERR--EQ 517
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
+E +E LQ+ L + R E + ++ E R + E ++ L+ + + D
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 535 ILLKRKLEEHLQKL---HEADLELQRKREYIEELEP----------------------PT 569
LLKR+ E Q+L E LE + KRE +E LE +
Sbjct: 578 -LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636
Query: 570 DSSTARRIEELQHNLQ-------KKDADLRAMEERYRRYVDKARMVMQTMEPKQRPA--- 619
+ RR ++L+ Q K++ + +E+R +R ++ R + E +Q A
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Query: 620 --AGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLIS----AWYNMGMALQ 673
+ P L ++ R ++ E R ++EQEEK W A +
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756
Query: 674 QRAGEERA-------PAHAQSFLAQQRLATNSRRGPLGRLASLNLRPTDK 716
Q+ EE+ A +S +QRL S R PL LR ++
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRL---SARPPLREQRERQLRAEER 803
Score = 90.9 bits (224), Expect = 4e-18
Identities = 151/585 (25%), Positives = 234/585 (40%), Gaps = 75/585 (12%)
Query: 171 DSQSRRYYFLSEEAEEGDELQQRCLDLERQL----------MLLSEEKQSLAQENAGLRE 220
+ + RR L + EE + LQQR L E+QL +L EE++ L QE +
Sbjct: 510 EQEERREQRLKRQEEE-ERLQQR-LRSEQQLRREQEERREQLLKREEEKRLEQERR--EQ 565
Query: 221 RMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGRED-ERLRCAE-----LEREVA 274
R+ R + E L ++ Q +L++ QEE RE+ ERL E L+RE
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP 625
Query: 275 ELQHRNQALTSLAQEA---QALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQV 331
E + R Q L S QE Q L+ E E R+ + + E L +R E E RR+
Sbjct: 626 EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR--EHEEERREQ 683
Query: 332 RQLEERNAGHAERTR--------QLEDEL------------RRAGSLRAQL--EAQRRQV 369
EE ER + QLE E ++ G R Q E +RR+
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743
Query: 370 QELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPR 429
ELQ Q +E A + ++ + R+ ++++ +EK +R S R E R QL+
Sbjct: 744 SELQWQEEERAHRQQQEEEQRRDFTWQWQA--EEKSERGRQRLSARPPLREQRERQLRAE 801
Query: 430 GLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHL 489
Q + P + + RE L+ E ++L R+E A ++ QEE
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQ---RREREKELQFLEEEEQLQRRERA-QQLQEEEDGLQ 857
Query: 490 EDANRARHGLETQHRLNQQQLSE--------------LRAQVEDLQKALQEQGGKTEDSI 535
ED R R + + + + QL E L+ Q+ Q+ LQE+ + +
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 536 LLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAME 595
KR+ +E ++ E + Q + + + E R LQ+K+ L E
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 596 ERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQRE 655
RR ++ + + E +Q E R Q ER R + E+ E+ + RE
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD-ELQQEEEQLLRE 1036
Query: 656 QEEKLLI---SAWYNMGMALQQR----AGEERAPAHAQSFLAQQR 693
+ EK + Y LQQ GEER Q Q R
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Score = 90.1 bits (222), Expect = 6e-18
Identities = 122/493 (24%), Positives = 205/493 (41%), Gaps = 36/493 (7%)
Query: 177 YYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAK 236
YY L + +E + RC E LL + +Q Q R+R E PG +
Sbjct: 86 YYALGQATGLDEEKRARCDGKES---LLQDRRQEEDQRRFEPRDRQLEEE----PGQRRR 138
Query: 237 KLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDE 296
Q + EQ +E E + ERL + +R EL + Q QE + + E
Sbjct: 139 -----QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW----QEREERRAE 189
Query: 297 MDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQL--EDELRR 354
++L+ + RRR EL ELRR+ R EE+ ER ++ E+E +
Sbjct: 190 EEQLQSCKGHETEEFPDEEQLRRR--ELLELRRKGR--EEKQQQRRERQDRVFQEEEEKE 245
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWL--FECRNLEEKYESVTKEKERLLAERD 412
L + ++QE + QRQ E + E+ L E + L + + ++++RL E+
Sbjct: 246 WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQ 305
Query: 413 SLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKR-- 470
R+ EE R Q + R Q + L E E RE LR + E +R
Sbjct: 306 LRRKQEEERREQQEERR--EQQERREQQEERREQQLRRE--QEERREQQLRREQEEERRE 361
Query: 471 -LCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGG 529
R+E + R+++L+R E R L + +L ++Q Q+ Q+ +EQ
Sbjct: 362 QQLRREQEEERREQQLRR--EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 530 KTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDA 589
+ E + +++ E H QK + E + KRE E + R E+ + Q K
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 590 DLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRI-RHLEMDFE 648
ER+ + ++ R Q E +++ E R + +E + R+ + L + +
Sbjct: 480 QEEERRERWLKLEEEERREQQ--ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 649 KSRSQREQEEKLL 661
R Q E+ E+LL
Sbjct: 538 LRREQEERREQLL 550
Score = 89.0 bits (219), Expect = 1e-17
Identities = 144/603 (23%), Positives = 257/603 (42%), Gaps = 111/603 (18%)
Query: 127 KKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEE 186
++++ + + LEE Q E Q+L ++ D L + + RR + EE
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEE--DGLQEDQERRRSQEQRRDQKWRWQLEE 880
Query: 187 GDELQQRCL--------DLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGT----PGLT 234
+ ++ L L ++ LL EE++ L +E RE+ R E E L
Sbjct: 881 ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE---REKRRRQEQERQYREEEQLQ 937
Query: 235 AKKLLLLQSQLE----QLQEENFRLES----------GREDERLRCAELE---REVAELQ 277
++ LL+ + E Q +E +R + G E E+ R E E RE ELQ
Sbjct: 938 QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ 997
Query: 278 HRNQALTSLAQEAQALKD------EMDELRQSSERAGQLEATLTSCRRRLGELRELRRQV 331
+ L +E + ++ + DEL+Q E+ + E + R + RE ++
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE-EEEL 1056
Query: 332 RQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECR 391
+Q EE+ G TR+ R +LE Q R+ +ELQ Q +E+ ++ E E R
Sbjct: 1057 QQEEEQLLGEERETRR-----------RQELERQYRKEEELQ-QEEEQLLREEP---EKR 1101
Query: 392 NLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAE 451
+E+ +E+E E LRE E+ R +L+ + + + + + L E
Sbjct: 1102 RRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE-----EQLLRE 1156
Query: 452 ILPAELRETLLR-------LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHR 504
R+ L R LQ E ++L R+E ++ RQE +++ E+ R + ++R
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEEQLLREE-QEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 505 LNQQQLSELRAQVE-DLQKALQ-----------EQGGKTEDSILLKRKLEEHLQKL---- 548
++ Q S+L+ Q E + + A++ EQ + EDS L R+ ++ LQ L
Sbjct: 1216 -DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 549 HEADLELQRKR-----------EYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEER 597
E D E +R+R E +E E R+ +E + L+++ + R +E
Sbjct: 1275 QERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 598 YRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQE 657
R++ ++ +++ + E LR Q R+R R L E+ R E+E
Sbjct: 1335 DRKFREEEQLLQEREE-------------QPLRRQERDRKFREEELRHQ-EQGRKFLEEE 1380
Query: 658 EKL 660
++L
Sbjct: 1381 QRL 1383
Score = 85.1 bits (209), Expect = 2e-16
Identities = 132/558 (23%), Positives = 228/558 (40%), Gaps = 98/558 (17%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPE---------------- 226
E E G +Q+ + ER+L E+QS QE R+R R E
Sbjct: 130 EEEPGQRRRQKRQEQERELA--EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
Query: 227 ----------GEGT------PGLTAKKLLLL--------QSQLEQLQEENFRLES----- 257
G T L ++LL L Q Q + Q+ F+ E
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR 247
Query: 258 ------GREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLE 311
+E+E+L+ E +R+ ELQ + L L E Q L+ E E Q +R + +
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQ-RELQEEEEQLRKL--ERQELRRERQEEEQQQQRLRREQ 304
Query: 312 ATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQ- 370
E +E RR+ ++ E+ E+ + E E RR LR + E +RR+ Q
Sbjct: 305 QLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQL 364
Query: 371 --ELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQP 428
E + +R+E+ ++ E+ L + L + + +E+ L LR + R QL+
Sbjct: 365 RREQEEERREQQLRREQQLRREQQLRREQQ---LRREQQLRREQQLRREQQLRREQQLRR 421
Query: 429 RGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKR--LCRQEAADRERQE--- 483
+ + + + E RE L+ + E +R L R+E +R QE
Sbjct: 422 EQQLRREQEEERHEQKHEQ--------ERREQRLKREQEERRDWLKREEETERHEQERRK 473
Query: 484 -ELQRHLEDANRARH-GLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSIL----- 536
+L+R E+ R R LE + R QQ+ E + + E ++ Q + E+ L
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 537 ----LKRKLEEHLQKL----HEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKD 588
L+R+ EE ++L E LE +R+ + ++ + +R EE + K++
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKRE 593
Query: 589 ADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPE-----LHSLRTQLRERDVRIRHL 643
+ R +E+R +R ++ + Q +QR P E L Q R ++R
Sbjct: 594 QEER-LEQRLKR--EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRRE 650
Query: 644 EMDFEKSRSQREQEEKLL 661
+ + + R +RE+EE+ L
Sbjct: 651 QQERREQRLKREEEEERL 668
Score = 85.1 bits (209), Expect = 2e-16
Identities = 132/519 (25%), Positives = 221/519 (42%), Gaps = 84/519 (16%)
Query: 171 DSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGT 230
+ + RR + + DELQQ E QL+ EK+ L + RER R E E
Sbjct: 1007 EREKRRRQEWERQYRKKDELQQE----EEQLLREEREKRRLQE-----RERQYREEEE-- 1055
Query: 231 PGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEA 290
LQ + EQL G E E R ELER+ + + Q +E
Sbjct: 1056 ----------LQQEEEQLL--------GEERETRRRQELERQYRKEEELQQ------EEE 1091
Query: 291 QALKDEMDELR-QSSERAGQLEATLTSCRRRLGELRELRRQVRQLE-ERNAGHAERTRQL 348
Q L++E ++ R Q ER + E L +L LRE R + R+ E ER E +Q
Sbjct: 1092 QLLREEPEKRRRQERERQCREEEELQQEEEQL--LREEREKRRRQELERQYREEEEVQQE 1149
Query: 349 EDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
E++L LR + E +RRQ E Q + +EE + E+ L L E+ E +E+ER
Sbjct: 1150 EEQL-----LREEPEKRRRQELERQYREEEELQQEEEQL-----LREEQEKRRQERERQY 1199
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLA----------AEILPAELR 458
E + L+ + R R + + + DN ++ ++LR
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259
Query: 459 ETLLRLQLENKRLCRQEAADRE----RQEELQRHLEDANR----ARHGLETQHRLNQQQL 510
+ + L++ L Q+ DRE R ++ RH + + + + + R +Q++
Sbjct: 1260 DRQSQQDLQHL-LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Query: 511 SELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHL------QKLHEADLELQRK-REYIE 563
LR + E+ ++ + E+ LL+ + E+ L +K E +L Q + R+++E
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378
Query: 564 ELEPPTDSSTARRI--EELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAG 621
E + R+ EE Q Q+++ LR +R R ++ ++ Q + K R
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR-EEEQQLSRQERDRKFR---- 1433
Query: 622 APPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL 660
E +R Q RER ++ E+ R RE+E+ L
Sbjct: 1434 --EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLL 1470
Score = 79.0 bits (193), Expect = 1e-14
Identities = 129/538 (23%), Positives = 222/538 (41%), Gaps = 57/538 (10%)
Query: 173 QSRRYYFLSEEAEEGDELQQRCLDLERQLML-----LSEEKQSLAQENAGLRERMGRPEG 227
Q R FL EE Q RC + E+QL EE+Q L+++ R+R R E
Sbjct: 1386 QERERKFLKEEQ------QLRCQEREQQLRQDRDRKFREEEQQLSRQE---RDRKFREEE 1436
Query: 228 EGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLA 287
+ ++ L + Q QL++E R RE+E+L ERE +L + + L
Sbjct: 1437 QQVRRQERERKFLEEEQ--QLRQERHR--KFREEEQLL---QEREEQQLHRQERDRKFLE 1489
Query: 288 QEAQALKDEMD-ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQL----EERNAGHA 342
+E Q + E D + R+ R+ + E R+ L E ++L RQ RQ EE+
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPE------RKFLEEEQQLHRQQRQRKFLQEEQQLRRQ 1543
Query: 343 ERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTK 402
ER +Q + R QL Q R+ Q+L Q ++ + E+ + E K+
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLR-QEREEQQLSRQERDRKFRLEEQKVRRQEQERKF----M 1598
Query: 403 EKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLL 462
E E+ L ++ ++ +E + L Q D E E L
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE------EEPQL 1652
Query: 463 RLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQK 522
R Q ++L +E+L + E+ R + + R +QQL + E +K
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL----RRQERERK 1708
Query: 523 ALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQH 582
LQE+ + K + EE L++ E + +L+R+ Y + LE + EE Q
Sbjct: 1709 FLQEEQQLRRQELERKFREEEQLRQETEQE-QLRRQERYRKILE---EEQLRPEREEQQL 1764
Query: 583 NLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRH 642
Q++D R EE+ R+ ++ ++ Q + K R E + + ++RD + R
Sbjct: 1765 RRQERDRKFRE-EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYR- 1822
Query: 643 LEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLATNSRR 700
+E+ + Q E++E+ L A +Q A +E++ Q ++ R
Sbjct: 1823 ----WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876
Score = 72.8 bits (177), Expect = 1e-12
Identities = 106/450 (23%), Positives = 196/450 (43%), Gaps = 44/450 (9%)
Query: 246 EQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL---RQ 302
EQL+ E + R+ + +L RE E + R Q +E + L E +E RQ
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 303 SSERAGQLEATL--TSCRRRLGELRELRRQVRQ----LEERNAGHAERTRQL-EDELRRA 355
+R + E R+ L E + LRRQ R+ EE+ ER +QL +D R+
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416
Query: 356 GSLRAQLEAQRR----QVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAER 411
QL Q R + +E Q +RQE + K+L E + L ++ +E+E+LL ER
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQE---RERKFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 412 DSL--------REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLR 463
+ R+ EE + + Q R + L + P E ++ +
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL-RSQEPERKFLEEEQQLHRQQRQRK 1532
Query: 464 LQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA 523
E ++L RQE + RQ+ R + + R E Q Q++ + R + + +++
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDR-DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591
Query: 524 LQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPT--DSSTARRIEELQ 581
QE+ ++ L +++ ++ L++ E D + + + ++E E R+ E +
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQ--ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 582 HNLQKKDADLRAMEERYRRYVDKARMVMQTMEP---KQRPAAGAPPELHSLRTQLRER-- 636
L++++ + + +R R++ ++ +++ + E +Q E LR Q RER
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709
Query: 637 -----DVRIRHLEMDF---EKSRSQREQEE 658
+R + LE F E+ R + EQE+
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQ 1739
Score = 67.4 bits (163), Expect = 4e-11
Identities = 110/426 (25%), Positives = 181/426 (42%), Gaps = 60/426 (14%)
Query: 151 QELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE--EGDELQQRCLDLER------QLM 202
QEL +++ P+ E Q R+ FL EE + + QQR D +R QL
Sbjct: 1506 QELRSQE-PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR 1564
Query: 203 LLSEEKQSLAQENAG---LRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGR 259
EE+Q QE L E+ R + + + ++ L Q +QL++E R R
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR--KFR 1622
Query: 260 EDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE-LRQSSERAGQLEATLTSCR 318
EDE+L ERE +L + + L +E Q + E ++ LR +R + E L
Sbjct: 1623 EDEQLL---QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL--- 1676
Query: 319 RRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQE 378
+ GE ++LRRQ R + R+ E +LRR E +R+ +QE Q R++
Sbjct: 1677 -QEGEEQQLRRQERD---------RKFREEEQQLRRQ-------ERERKFLQEEQQLRRQ 1719
Query: 379 EAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSL 438
E + + + R E+ + +E+ R + E + LR EE + + + + +
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE--- 1776
Query: 439 DPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHG 498
E L E E LR Q E+ R R+E ++ RQE ++ L R
Sbjct: 1777 ------------EQLRQEREEQQLRSQ-ESDRKFREE--EQLRQEREEQQLRPQQRDGKY 1821
Query: 499 LETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRK 558
+ +L ++ + Q D Q +EQ E S R+ E+ L + E +R+
Sbjct: 1822 RWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS----RREEQELWQEEEQKRRQERE 1877
Query: 559 REYIEE 564
R+ EE
Sbjct: 1878 RKLREE 1883
Score = 54.3 bits (129), Expect = 4e-07
Identities = 80/294 (27%), Positives = 128/294 (43%), Gaps = 30/294 (10%)
Query: 147 MEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSE 206
ME Q+L ++ L E D + R L +E EE +Q ER L E
Sbjct: 1598 MEDEQQLRRQEGQQQLRQER----DRKFREDEQLLQEREEQQLHRQ-----ERDRKFLEE 1648
Query: 207 EKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRC 266
E Q QE RE+ R + + ++ LL + + +QL+ + + E+++LR
Sbjct: 1649 EPQLRRQE----REQQLRHDRDRK--FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Query: 267 AELEREVA--ELQHRNQALTSLAQEAQALKDE--MDELRQSSERAGQLEATLTSCRRRLG 322
E ER+ E Q R Q L +E + L+ E ++LR+ LE R
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER--- 1759
Query: 323 ELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA-QLEAQRRQVQELQGQRQEEAM 381
E ++LRRQ R + R + R+ E +LR S R + E Q RQ +E Q R ++
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQERE-EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818
Query: 382 KAEKWLFECRNLEEKYESVTKEKER------LLAERDSLREANEELRCAQLQPR 429
+W E LEE+ + + +E++R A ++ R +EL + Q R
Sbjct: 1819 GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR 1872
Score = 50.1 bits (118), Expect = 7e-06
Identities = 67/227 (29%), Positives = 104/227 (45%), Gaps = 26/227 (11%)
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQL 248
E +Q+ ER+ L EE+Q QE ER R E + ++L + + L
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQE----LERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 249 QEENFRLESGREDERLRCAELEREVAE---LQHRNQALTSLAQEAQALKDEMDELRQSSE 305
+EE R E RE+++LR E +R+ E L+ + +QE+ E ++LRQ E
Sbjct: 1751 EEEQLRPE--REEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQERE 1808
Query: 306 RAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQ 365
QL ++R G+ R Q+ QLEE+ +R RQ D RA A E
Sbjct: 1809 EQ-QLRP-----QQRDGKYRWEEEQL-QLEEQE----QRLRQERDRQYRAEEQFATQEKS 1857
Query: 366 RRQVQEL-----QGQRQEEAMK-AEKWLFECRNLEEKYESVTKEKER 406
RR+ QEL Q +RQE K E+ + + E+++ V + K +
Sbjct: 1858 RREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 90.9 bits (224), Expect = 4e-18
Identities = 125/492 (25%), Positives = 211/492 (42%), Gaps = 57/492 (11%)
Query: 135 IMTLEESVQHVVMEAIQ-ELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQR 193
I +LEE V + + ++ E +K+ + E+ + + R +E A +R
Sbjct: 1227 ISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAER 1286
Query: 194 CLDLERQLMLLSEE--KQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEE 251
L ++ L EE KQ +A EN LR+ + A++ L +L+ QE+
Sbjct: 1287 SSALREEVQSLREEAEKQRVASEN--LRQELTSQ---------AERAEELGQELKAWQEK 1335
Query: 252 NFRLESGREDERLRCAELEREVAELQHRNQALTSL-AQEAQALKDEMDELRQSSERAGQL 310
F+ E +L + V+EL L A++A A K +EL QS + AG L
Sbjct: 1336 FFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGL 1395
Query: 311 EATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQ 370
A L +R LGEL LR++V + +ER A +QL E +A Q ++
Sbjct: 1396 RAELLRAQRELGELIPLRQKVAE-QERTA------QQLRAE-------KASYAEQLSMLK 1441
Query: 371 ELQGQRQEEAMKAEKWLFECRNLEEKYESV--TKEKERLLAERDSLREANEELRCAQLQP 428
+ G EE + L E NL ++ V + +E+ + E ++R A+ E R A++Q
Sbjct: 1442 KAHGLLAEE----NRGLGERANLGRQFLEVELDQAREKYVQELAAVR-ADAETRLAEVQR 1496
Query: 429 RGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQ----EAADRERQ-- 482
+ A L+ + + ++L E R Q E ++L Q E RE+
Sbjct: 1497 EAQSTA-RELEVMTAKYEGAKVKVL-----EERQRFQEERQKLTAQVEQLEVFQREQTKQ 1550
Query: 483 -EELQRHLEDANRAR-------HGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
EEL + L D+++A ++ Q +QQ+ L+AQ+ +LQ L ++ E
Sbjct: 1551 VEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY 1610
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAM 594
L K + H + + ELQ + +E+L+ A E L H LQ+ +
Sbjct: 1611 KLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA-EAERLGHELQQAGLKTKEA 1669
Query: 595 EERYRRYVDKAR 606
E+ R + R
Sbjct: 1670 EQTCRHLTAQVR 1681
Score = 77.4 bits (189), Expect = 4e-14
Identities = 134/535 (25%), Positives = 221/535 (41%), Gaps = 78/535 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L E AE+ + +Q D +QL +EE+++ +E +++ E E A KL
Sbjct: 567 LKEVAEKQEATRQ---DHAQQLATAAEEREASLRERDAALKQLEALEKE-----KAAKLE 618
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMD- 298
+LQ QL+ E ++ + AEL R+V ELQ + EAQA E++
Sbjct: 619 ILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELEL 678
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSL 358
+LR ++A + E R E +L+ Q++ L+E LE+E RRA
Sbjct: 679 QLRSEQQKATEKE-------RVAQEKDQLQEQLQALKE---SLKVTKGSLEEEKRRAAD- 727
Query: 359 RAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREAN 418
LE Q+R + EL+ E R+L E+++ KE E A R L
Sbjct: 728 --ALEEQQRCISELKA--------------ETRSLVEQHKRERKELEEERAGRKGLEARL 771
Query: 419 EELRCA-----QLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKR--- 470
++L A ++ R L +A + + + L E+ A RE Q E +
Sbjct: 772 QQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEV--AAWRERYEDSQQEEAQYGA 829
Query: 471 -LCRQEAADRERQEELQRHLEDANRARHGLETQHRL----NQQQLSELRAQVEDLQKALQ 525
Q +E E+ ++ L++A G+E+ L Q +L+EL A +L +ALQ
Sbjct: 830 MFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHA---NLARALQ 886
Query: 526 EQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEEL--EPPTDSSTARRIEELQHN 583
+ ++ + +KL + L L E ++ +E L + TA R E ++
Sbjct: 887 Q----VQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASR-ELVKEP 941
Query: 584 LQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHL 643
+ D +EE+ R + +Q ME R A EL LR L E
Sbjct: 942 ARAGDRQPEWLEEQQGRQFCSTQAALQAME---REAEQMGNELERLRAALMESQ------ 992
Query: 644 EMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPA----HAQSFLAQQRL 694
+ + +R Q+E+ + G A A E+ A A Q+ L +QR+
Sbjct: 993 ----GQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRV 1043
Score = 76.6 bits (187), Expect = 7e-14
Identities = 160/747 (21%), Positives = 295/747 (39%), Gaps = 118/747 (15%)
Query: 11 SLLTWLQTFHVPSPCASPQDLSSGLAVAYVLNQIDPSWFNEAWL-QGISEDPGPNWKLKV 69
+LL+W+ + HV P + L ++++I + + L Q +SE
Sbjct: 10 ALLSWVNSLHVADPVEAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSER--------- 60
Query: 70 SNLKMVLRSLVEYSQDVLAHPVSEEHLPDVSLIGEFSDPAELGKLLQLVL-GCAISCEKK 128
L + + Q HP S E L + E S+ EL K+ L+L +S +
Sbjct: 61 ------LDFVCSFLQKNRKHPSSPECLVSAQKVLEGSE-LELAKMTMLLLYHSTMSSKSP 113
Query: 129 QDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD 188
+D Q E +Q + ++ ++ + +L+ E NF ++ S E
Sbjct: 114 RDWEQ----FEYKIQAELAVILKFVLDHEDGLNLN-EDLENFLQKAPVPSTCSSTFPE-- 166
Query: 189 ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQL 248
EL +R++ L E Q +A ++G G P + L+
Sbjct: 167 ELSPPSHQAKREIRFL--ELQKVASSSSGNNFLSGSPASP------------MGDILQTP 212
Query: 249 QEENFRLESGREDERLRCAELEREVAE--------------LQHRNQALTSLAQEAQALK 294
Q + RL+ DER ELE E+AE +Q R L +L E QA
Sbjct: 213 QFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRL-ALLNEKQAAS 271
Query: 295 ----DEMDELRQSSER-AGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLE 349
E++ELR +E +L TL C+ E ++ R++ QL E N + + R+
Sbjct: 272 PLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 350 DELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKA-EKWLFECRNLEEKYESVTKEK---- 404
L +Q+Q+ + EE KA ++WL + LE++ + ++K
Sbjct: 332 SHL--------------QQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLE 377
Query: 405 ---ERLLAERDSLREANEELRCAQLQPRGLTQADP-SLDPTSTPVDNLAAEILPAELRET 460
E L + L E +L+ Q +G D L+ LAA + R
Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437
Query: 461 LL---RLQLENKRLCRQEAADRERQE------ELQRHLEDANRARHGLETQHRLNQQQL- 510
+L R Q E K L + + E+Q+ +LQ + + ++A+ LE + + +L
Sbjct: 438 MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497
Query: 511 -------SELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEA-----------D 552
SEL +Q+ QE G + + + +L + LQ+ +A
Sbjct: 498 AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557
Query: 553 LELQRKREYIEELEPPTDSS-------TARRIEELQHNLQKKDADLRAMEERYRRYVDKA 605
L++K + ++E+ +++ A EE + +L+++DA L+ +E + K
Sbjct: 558 SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL 617
Query: 606 RMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAW 665
++ Q ++ A + + + E ++ L+ E +R Q + E + ++
Sbjct: 618 EILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETAR-QEQHEAQAQVAEL 676
Query: 666 YNMGMALQQRAGEERAPAHAQSFLAQQ 692
+ QQ+A E+ A + L +Q
Sbjct: 677 ELQLRSEQQKATEKERVAQEKDQLQEQ 703
Score = 70.9 bits (172), Expect = 4e-12
Identities = 119/520 (22%), Positives = 221/520 (42%), Gaps = 79/520 (15%)
Query: 197 LERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLE 256
LE + E++++ ++E R G + E ++ Q+ L+ ++ E ++
Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM- 977
Query: 257 SGREDERLRCA-------------ELEREVAEL-QHRNQALTSLAQEAQA-------LKD 295
G E ERLR A + EREVA L Q R +A LA E A L++
Sbjct: 978 -GNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQN 1036
Query: 296 EMDELRQS------------SERAGQLEATLTSCR----RRLGELRELRRQVRQLEERNA 339
++E R +E+ G+ + L R ++ EL ELR+ V+QL+E+ A
Sbjct: 1037 ALNEQRVEFATLQEALAHALTEKEGK-DQELAKLRGLEAAQIKELEELRQTVKQLKEQLA 1095
Query: 340 G----HAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEE 395
HA + + R +LEA R +V +L+ Q Q++ +A+ R+LE
Sbjct: 1096 KKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLE---RSLEA 1152
Query: 396 KYESVTKEKERLLAERDSLREANEELRCAQ----LQPRGLTQADPSLDPTSTPVDNLAAE 451
+ S + L + L E +EL +Q R L + S D A+
Sbjct: 1153 ERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQ 1212
Query: 452 IL----PAELRETLLRLQLENKRLCRQEAADRE-RQEELQRHLEDANRARHGLETQHRLN 506
+ AE + +L+ E + ++ ++E +EL+R + + LE + RL
Sbjct: 1213 VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLL 1272
Query: 507 Q-----------QQLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLEL 555
Q ++ S LR +V+ L++ ++Q +E+ L+++L ++ E EL
Sbjct: 1273 QAETASNSARAAERSSALREEVQSLREEAEKQRVASEN---LRQELTSQAERAEELGQEL 1329
Query: 556 QRKREYIEELEPPTD------SSTARRIEEL---QHNLQKKDADLRAMEERYRRYVDKAR 606
+ +E + E +ST + EL +H Q+ A+ A E+R+R +++++
Sbjct: 1330 KAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK 1389
Query: 607 MVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMD 646
+ + A EL LR ++ E++ + L +
Sbjct: 1390 QAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAE 1429
Score = 55.1 bits (131), Expect = 2e-07
Identities = 91/450 (20%), Positives = 185/450 (41%), Gaps = 57/450 (12%)
Query: 277 QHRNQALTSLAQEAQALKDEMD-ELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLE 335
Q + + L + ++ +DE++ EL ++ + + +A + ++R+ L L
Sbjct: 213 QFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLA-------LLN 265
Query: 336 ERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEE 395
E+ A ++LE+ + SL +L +Q Q+L+ ++ + K + E +L
Sbjct: 266 EKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSF 325
Query: 396 KYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPA 455
K ++L + L E + + L+ + + + S EIL
Sbjct: 326 KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQG 385
Query: 456 ELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRA 515
+L QLE Q+ +E+ E L L+ LET +Q+ + L A
Sbjct: 386 KLS------QLEEHLSQLQDNPPQEKGEVLGDVLQ--------LETL----KQEAATLAA 427
Query: 516 QVEDLQ---KALQEQGGKTEDSILLKR-KLEEHLQKLHEADLELQRKREYI----EELEP 567
LQ + L+ + G+ E +L +R EE Q+L +LQ + EELE
Sbjct: 428 NNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ 487
Query: 568 PTDSSTAR----------RIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQR 617
+ + AR + L +Q++D +L ++++ + +K + QT++ +++
Sbjct: 488 ASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAK---EKQAQLAQTLQQQEQ 544
Query: 618 PAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISA-------WYNMGM 670
+ G ++ L + L++++ +++ + EK + R+ + L +A
Sbjct: 545 ASQGLRHQVEQLSSSLKQKEQQLKEVA---EKQEATRQDHAQQLATAAEEREASLRERDA 601
Query: 671 ALQQRAGEERAPAHAQSFLAQQRLATNSRR 700
AL+Q E+ A L QQ N R
Sbjct: 602 ALKQLEALEKEKAAKLEILQQQLQVANEAR 631
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 89.7 bits (221), Expect = 8e-18
Identities = 156/688 (22%), Positives = 282/688 (40%), Gaps = 96/688 (13%)
Query: 101 LIGEFSD-PAELGKLLQLVLGCAISCEKKQDHIQRIM------TLEESVQHVVMEAIQEL 153
L GE +D ++ +L + + KK++ +Q + TL ++ V+ +Q
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 154 MTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEE-GDELQQRCLDLERQLMLLSEEKQSLA 212
+ + D S + N + +R LSEE E EL+ Q L ++ +Q +A
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRD--LSEELEALKTELEDTLDTTAAQQELRTKREQEVA 1177
Query: 213 QENAGLRERMGRPEGE--GTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELE 270
+ L E E + A L L QLEQ + LE ++ EL
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELA 1237
Query: 271 REV-------AELQHRNQALTSLAQEAQALKDEMDELR-QSSERAGQLEATLTSCRRRLG 322
EV AE +H+ + L + QE A E D LR + +E+A +L+ L + L
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297
Query: 323 EL--------RELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQG 374
E ++ QL++ E TRQ +L + +R QLE ++ +QE Q
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQ---KLNLSSRIR-QLEEEKNSLQEQQE 1353
Query: 375 QRQEEAMKAEKWLF----ECRNLEEKY-------ESVTKEKERLLAERDSLREANEELRC 423
+ +E EK + + + ++K ES+ + K++LL + ++L + EE
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413
Query: 424 AQLQ-PRGLTQADPSLDPTSTPVDNLAAEILPAELRETLL-RLQLENKRLCRQEAADRER 481
A + + + LD + +D+ E ++ +L E K + + A +R+R
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1473
Query: 482 QE-----------ELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGK 530
E L R LE+A A+ E Q++ +LRA +EDL + + G
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNK-------QLRADMEDLMSSKDDVGKN 1526
Query: 531 TEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDAD 590
+ KR LE+ ++++ EL+ + + E+ + + + + + +LQ +D
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 591 LRAMEERYRRYVDKARMVMQTMEP--KQRPAAGAPP-----ELHSLRTQ----------- 632
EE+ R + + R + +E KQR A A +L L Q
Sbjct: 1587 ---NEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 633 ---LRERDVRIRHLEMDFEKSRSQREQ-------EEKLLISAWYNMGMALQQRAGEERAP 682
LR+ +++ + + E++R+ R++ EK L S + ++ A ERA
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703
Query: 683 AHAQSFLAQQRLATNSRRGPLGRLASLN 710
HA+ + LA G+ A L+
Sbjct: 1704 RHAEQ--ERDELADEITNSASGKSALLD 1729
Score = 84.0 bits (206), Expect = 5e-16
Identities = 111/523 (21%), Positives = 231/523 (44%), Gaps = 74/523 (14%)
Query: 200 QLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQL--EQLQEENFRLES 257
Q+ EE Q+ +E ++E+ + EGE + LL + + EQLQ E L +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET-ELFA 904
Query: 258 GREDERLRCAELEREVAELQH-----------RNQALTSLAQEAQA----LKDEMDELRQ 302
E+ R R A ++E+ E+ H RNQ L + ++ QA L++++DE +
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE-EE 963
Query: 303 SSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQL 362
+ + QLE + ++++ ++ LE++N+ + + +ED + S A+
Sbjct: 964 GARQKLQLEKVTAEAK-----IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018
Query: 363 EAQRRQVQELQGQR-------QEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR 415
E + + + +++ ++ +E K EK E + K + T + + +AE L+
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAE---LQ 1075
Query: 416 EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQ--LENKRLCR 473
+EL+ + Q + T N A +++ EL+ + LQ E+++ R
Sbjct: 1076 AQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV-RELQAQIAELQEDFESEKASR 1134
Query: 474 QEAADRERQ-----EELQRHLEDANRARHGLETQHRLNQQQLSELR-----------AQV 517
+A ++R E L+ LED + +Q+++EL+ AQ+
Sbjct: 1135 NKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 518 EDLQK----ALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSST 573
+D+++ AL+E + E + K LE++ Q L + EL + + +++++ ++
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 574 AR---RIEELQHNLQKKD---ADLRAMEERYRRYVDKARMVMQTMEPK----QRPAAGAP 623
+ +++EL + + D +L + + +D +++ E K + AA
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 624 PELHSLRTQLRER-------DVRIRHLEMDFEKSRSQREQEEK 659
+L + L+E RIR LE + + Q+E+EE+
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Score = 80.1 bits (196), Expect = 7e-15
Identities = 112/468 (23%), Positives = 196/468 (41%), Gaps = 76/468 (16%)
Query: 236 KKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
K LL + Q E+LQ ++ L +E + ++E E+ E++ ++Q L +E L +
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQ----TKVEGELEEMERKHQ---QLLEEKNILAE 894
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGE-LRELRRQVRQLEERNAGHAERTRQLEDELRR 354
++ + A ++ A L + ++ L E L +L +V + EERN ++++ ++
Sbjct: 895 QLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ- 953
Query: 355 AGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL------- 407
L QL+ + Q+LQ ++ K +K E LE++ KEK+ +
Sbjct: 954 --DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 408 ---LAERDS---------------LREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLA 449
LAE + + + E L+ + + L +A LD +T + +
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 450 AEILPAELRETLLRLQLENKRLCRQEAADRERQE-------------------ELQRHLE 490
AE L A++ E L+LQL K Q A R E ELQ E
Sbjct: 1072 AE-LQAQIDE--LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 491 DANRARHGLETQHRLNQQQLSELRAQVE---DLQKALQEQGGKTEDSILLKRKLEEHLQK 547
+R+ E Q R ++L L+ ++E D A QE K E + +K E K
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 548 LHEADLELQRKRE--YIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKA 605
HEA ++ R+R +EEL S + + + NL+K L + V
Sbjct: 1189 NHEAQIQDMRQRHATALEEL-----SEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243
Query: 606 RMVMQTMEPKQRPAAGAPPELHS-------LRTQLRERDVRIRHLEMD 646
+ V E K++ ELH+ LR +L E+ ++++ E+D
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN-ELD 1290
Score = 62.8 bits (151), Expect = 1e-09
Identities = 83/389 (21%), Positives = 170/389 (43%), Gaps = 71/389 (18%)
Query: 283 LTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA 342
L + ++ + L+ + +EL + E+ ++E GEL E+ R+ +QL E A
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVE----------GELEEMERKHQQLLEEKNILA 893
Query: 343 ERTRQLEDELRRAGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECRNLEEKYE 398
E+ + + A +RA+L A++++++E L+ + +EE EE+ +
Sbjct: 894 EQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE--------------EERNQ 939
Query: 399 SVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELR 458
+ EK+++ A L E +E A+ ++ + AE ++
Sbjct: 940 ILQNEKKKMQAHIQDLEEQLDEEEGAR---------------QKLQLEKVTAEAKIKKME 984
Query: 459 ETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQV- 517
E +L L+ +N + +++ +R E L + L + +S+L ++
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 518 ------EDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDS 571
++L+KA ++ G+T D L+ ++ E ++ E L+L +K E ++ D
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTD---LQDQIAELQAQIDELKLQLAKKEEELQGALARGDD 1101
Query: 572 STARRIEELQ--HNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSL 629
T + L+ LQ + A+L+ E + +KA E ++R + EL +L
Sbjct: 1102 ETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA-------EKQKRDLS---EELEAL 1151
Query: 630 RTQLRER-DVRIRHLEMDFEKSRSQREQE 657
+T+L + D E+ R++REQE
Sbjct: 1152 KTELEDTLDTTAAQQEL-----RTKREQE 1175
Score = 61.6 bits (148), Expect = 2e-09
Identities = 82/394 (20%), Positives = 172/394 (43%), Gaps = 32/394 (8%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRP------EGEGTPGLTAKKL 238
++ +E++ + +LE +L + K L ++ + R + E L K++
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Query: 239 LLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEM- 297
L+++LE +++ + ++ + +LE A+++ N+A + ++ + L+ +M
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLE---AQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 298 DELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAG------HAERTR-QLED 350
D R+ E + + +L+ L ++ QL+E A HAE+ R +L D
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 351 ELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAE 410
E+ + S ++ L ++R+++ Q +EE + + L +++ T + + L AE
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQS---NMELLNDRFRKTTLQVDTLNAE 1772
Query: 411 RDSLREANEELRCAQLQ-PRGLTQADPSLDPTSTPVDN-LAAEILPAELRETLLRLQLEN 468
+ R A ++ A+ Q R + L V + A I E + L QLE
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE- 1831
Query: 469 KRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLN----QQQLSELRAQVEDLQKAL 524
QEA +R +L R E + R + ++Q+ + A+++ L++ L
Sbjct: 1832 -----QEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL 1886
Query: 525 QEQGGKTEDSILLKRKLEEHLQKLHEADLELQRK 558
+E + + +RKL+ L EA+ L R+
Sbjct: 1887 EEAEEEATRANASRRKLQRELDDATEANEGLSRE 1920
Score = 60.8 bits (146), Expect = 4e-09
Identities = 62/256 (24%), Positives = 117/256 (45%), Gaps = 30/256 (11%)
Query: 186 EGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL----- 240
+ E +++ LE +++ L EE S + + E T + K LL
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRR 1733
Query: 241 LQSQLEQLQEENFRLESGRE--DERLRC---------AELEREVAELQHRNQALTSLAQE 289
L++++ QL+EE +S E ++R R AEL E + Q + A L ++
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQ 1793
Query: 290 AQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGH--AERTR- 346
+ LK ++ EL + + + +AT+++ ++G+L E Q + +ER A + RT
Sbjct: 1794 NKELKAKLQELEGAVK--SKFKATISALEAKIGQLEEQLEQ--EAKERAAANKLVRRTEK 1849
Query: 347 -------QLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYES 399
Q+EDE R A + Q+E ++++L+ Q +E +A + R L+ + +
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Query: 400 VTKEKERLLAERDSLR 415
T+ E L E +L+
Sbjct: 1910 ATEANEGLSREVSTLK 1925
Score = 39.7 bits (91), Expect = 0.010
Identities = 37/172 (21%), Positives = 73/172 (42%), Gaps = 5/172 (2%)
Query: 208 KQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGREDERLRCA 267
+Q L ++N L+ ++ EG A + L++++ QL+E+ LE ++
Sbjct: 1787 RQQLERQNKELKAKLQELEGAVKSKFKAT-ISALEAKIGQLEEQ---LEQEAKERAAANK 1842
Query: 268 ELEREVAELQHRNQALTSLAQEAQALKDEMDELR-QSSERAGQLEATLTSCRRRLGELRE 326
+ R +L+ + + A K++M++ + + QLE R R+
Sbjct: 1843 LVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRK 1902
Query: 327 LRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQE 378
L+R++ E N G + L++ LRR G + R+ L+G E
Sbjct: 1903 LQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLE 1954
Score = 35.4 bits (80), Expect = 0.19
Identities = 42/188 (22%), Positives = 88/188 (46%), Gaps = 21/188 (11%)
Query: 508 QQLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEP 567
+Q EL+A+ E+L K ++Q + ++RK ++ L++ + +LQ + E E E
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908
Query: 568 PTDSSTARR--IEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPE 625
A++ +EE+ H+L+ R EE R ++Q + K +
Sbjct: 909 MRARLAAKKQELEEILHDLES-----RVEEEEER------NQILQNEKKKMQ------AH 951
Query: 626 LHSLRTQLRERDVRIRHLEMDFEKSRSQ-REQEEKLLISAWYNMGMALQQRAGEERAPAH 684
+ L QL E + + L+++ + ++ ++ EE++L+ N +++ E+R A
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI-AE 1010
Query: 685 AQSFLAQQ 692
S LA++
Sbjct: 1011 CSSQLAEE 1018
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 89.0 bits (219), Expect = 1e-17
Identities = 127/546 (23%), Positives = 238/546 (43%), Gaps = 82/546 (15%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLL---- 240
EE + R +LE +++ L +EK L + E + E E GL K+LL
Sbjct: 865 EELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE-ERCEGLIKSKILLEAKV 923
Query: 241 --LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMD 298
L +LE+ +E N L + + + +C+ L+R++ +L+ LT + +E A ++++
Sbjct: 924 KELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE---LTLTKVEKEKHATENKVK 980
Query: 299 ELRQSSERAGQLEATLTSCRRRLGELRELRRQ-----------VRQLEERNAGHAERTRQ 347
L SE LE ++ + L+E +Q V L + NA ++T
Sbjct: 981 NL---SEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD 1037
Query: 348 LEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL 407
LE L + LRA LE +R+++ QE M E + + +EEK + E +L
Sbjct: 1038 LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEN---DKQQIEEKLKKKEFELSQL 1094
Query: 408 LAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLE 467
A+ D +E++ Q Q + + ++ L EI E LR ++E
Sbjct: 1095 QAKID-----DEQVHSLQFQKK--------IKELQARIEELEEEI----EAEHTLRAKIE 1137
Query: 468 NKRLCRQEAADRERQ-EELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKA-LQ 525
+R +D R+ EE+ LE+A+ A Q +N+++ +E + DL++A LQ
Sbjct: 1138 KQR------SDLARELEEISERLEEASGA---TSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 526 EQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIE----ELEPPTD---------SS 572
+ + L++K + + +L E LQR ++ +E EL+ D S
Sbjct: 1189 HEA----TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSK 1244
Query: 573 TARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
+ IE ++ + ++++A +E+ + + M ++ + + E SL +Q
Sbjct: 1245 SKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ 1304
Query: 633 LRERDVRIRHLEMDFEKSRSQREQEEK-------LLISAWYNMGMALQQRAGEERAPAHA 685
L + + L E+ + Q E+E K L S+ ++ + +Q E+ A A
Sbjct: 1305 LTKSK---QALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 686 QSFLAQ 691
Q L++
Sbjct: 1362 QRALSK 1367
Score = 71.2 bits (173), Expect = 3e-12
Identities = 110/513 (21%), Positives = 209/513 (40%), Gaps = 71/513 (13%)
Query: 189 ELQQRCLDLERQLML-------LSEEKQSLAQENAGLRERMGRPEGEGTPGL--TAKKLL 239
ELQ R +LE ++ + +++ LA+E + ER+ G + + K+
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173
Query: 240 LLQSQLEQLQEENFRLESG----REDERLRCAELEREVAELQHRNQALTSLAQEAQALKD 295
Q L+E + E+ R+ + AEL ++ LQ Q L +E LK
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ---KLEKEKSELKM 1230
Query: 296 EMDELRQS----SERAGQLEATLTSCRRRLGELR-----------ELRRQVRQLEERNAG 340
E+D++ + S+ +E T + + E++ +L Q +L+ +N
Sbjct: 1231 EIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGE 1290
Query: 341 HAERTRQLEDEL----RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEK 396
+ R + E + + +L QLE +RQ++E + A + +C L E+
Sbjct: 1291 LSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQ 1350
Query: 397 YESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAE 456
YE + K L + +L +AN E+ AQ + + T A + LA + AE
Sbjct: 1351 YEEEQEAKAEL---QRALSKANSEV--AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1405
Query: 457 LRETLLRLQLENKRLCRQEAADRERQ--------EELQRHLEDANRARHGLETQHRLNQQ 508
EN + A E+ E+L R LE ++ A L+ + R +
Sbjct: 1406 ----------ENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDK 1455
Query: 509 QLSELRAQVE----DLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEE 564
L+E + +++ +L+ A +E + + ++ EE + +L E + +E I +
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD 1515
Query: 565 LEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPP 624
L +I E NLQ+ + + +E+ V ++E ++
Sbjct: 1516 L--------TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567
Query: 625 ELHSLRTQLRERDVRIRHLEMDFEKSRSQREQE 657
EL ++++L +R V + E++ K SQR E
Sbjct: 1568 ELSQVKSEL-DRKVIEKDEEIEQLKRNSQRAAE 1599
Score = 65.5 bits (158), Expect = 2e-10
Identities = 114/553 (20%), Positives = 230/553 (41%), Gaps = 78/553 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
+ EE + + + LL E+ + + A L+ + + E T +
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
+Q + E+L+E +L +RL+ AE E A N SL + Q L+ E+++
Sbjct: 1383 AIQ-RTEELEEAKKKLA-----QRLQEAEENTETA-----NSKCASLEKTKQRLQGEVED 1431
Query: 300 LRQSSERAGQLEATLTSCRRRLGE-LRELRRQVRQLEERNAGHAERTRQLEDELRRAGSL 358
L + ER+ ATL +R + L E ++++ + + + +R L EL + +
Sbjct: 1432 LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNA 1491
Query: 359 RA----QLEAQRRQVQELQ-------------GQRQEEAMKAEKWLFECRN-----LEEK 396
QLE RR+ + LQ G+ +EA K +K + + ++ LEE
Sbjct: 1492 YEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEV 1551
Query: 397 YESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA---EIL 453
S+ E+ ++L + L + EL R + + D ++ A +L
Sbjct: 1552 EGSLEHEESKILRVQLELSQVKSEL------DRKVIEKDEEIEQLKRNSQRAAEALQSVL 1605
Query: 454 PAELR-----------------ETLLRLQLENKRLCRQEAADRERQEEL---QRHLEDAN 493
AE+R E ++L N+++ + R Q +L Q HL+DA
Sbjct: 1606 DAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDAL 1665
Query: 494 RARHGLETQHRLNQQQLSELRAQVEDLQKALQ--EQGGKTEDSILLKRKLEEHLQKLHEA 551
R+ L+ Q + +++ L ++E+++ AL+ E+ + + LL + +Q LH
Sbjct: 1666 RSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELL--DASDRVQLLHSQ 1723
Query: 552 DLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQT 611
+ L ++ +E + A+ E+++++Q+ R EE+ ++ + A M+ +
Sbjct: 1724 NTSLINTKKKLE-------ADIAQCQAEVENSIQES----RNAEEKAKKAITDAAMMAEE 1772
Query: 612 MEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMA 671
++ +Q +A +L +++ R+ E K ++ Q+ + + N
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV 1832
Query: 672 LQQRAGEERAPAH 684
Q+R E AH
Sbjct: 1833 EQKRGAEALKGAH 1845
Score = 61.6 bits (148), Expect = 2e-09
Identities = 70/290 (24%), Positives = 133/290 (45%), Gaps = 41/290 (14%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L + ++L+++ +ER+ LL EE + + ++ + E T L+ ++LL
Sbjct: 1661 LDDALRSNEDLKEQLAIVERRNGLLLEELEEM---------KVALEQTERTRRLSEQELL 1711
Query: 240 LLQSQLEQLQEENFRLESGR---EDERLRC-AELEREVAELQHRNQ----ALTSLAQEAQ 291
+++ L +N L + + E + +C AE+E + E ++ + A+T A A+
Sbjct: 1712 DASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAE 1771
Query: 292 ALKDEMDELRQSSERAGQLEATLTSCRRRLGELREL-----RRQVRQLEERNAGHAERTR 346
LK E D LE T+ + RL E +L ++Q+++LE R R
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE-------NRVR 1824
Query: 347 QLEDEL----RRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTK 402
+LE+EL +R R+V+E+ Q +E+ K + ++L +K ++ K
Sbjct: 1825 ELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEED----HKNILRLQDLVDKLQAKVK 1880
Query: 403 EKERLLAERDSLREANEEL-RCAQLQPRGLTQADPSLDPTSTPVDNLAAE 451
+R E + +AN +L RC ++Q L +A D + V+ L A+
Sbjct: 1881 SYKRQAEEAE--EQANTQLSRCRRVQ-HELEEAAERADIAESQVNKLRAK 1927
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 88.6 bits (218), Expect = 2e-17
Identities = 127/492 (25%), Positives = 210/492 (42%), Gaps = 57/492 (11%)
Query: 189 ELQQRCLDLERQLMLL---SEEKQSLAQENAGL------RERMGRPEGEGTPGLTAKK-- 237
EL+Q + +RQ+ L + EK++LA+E+AGL ER GR E L +K
Sbjct: 849 ELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEA 908
Query: 238 ----LLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQAL 293
L +Q QL QL+ +LE+ E + L A+ E EL Q + + ++A
Sbjct: 909 LEGSLFEVQRQLAQLEARREQLEA--EGQALLLAK-ETLTGELAGLRQQIIATQEKASLD 965
Query: 294 KDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELR 353
K+ M + +ER EA + +R +L+R R+ E QL+ +L+
Sbjct: 966 KELMAQKLVQAER----EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQ 1021
Query: 354 R-AGSLRAQLEAQRRQVQE----LQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLL 408
R L A+LEA++ ++ E LQ +R E + AE + +L+E ++ EK L+
Sbjct: 1022 REQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK--LM 1079
Query: 409 AERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLEN 468
R SL + E+ + + + D S L +ELR+ LR Q E
Sbjct: 1080 GTRHSLATISLEMERQKRDAQSRQEQDRS-----------TVNALTSELRD--LRAQREE 1126
Query: 469 KRLCRQEAADR--ERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ R E+ +L + + R L TQ RL + LR ++ + Q+ L+E
Sbjct: 1127 AAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE 1186
Query: 527 QGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQK 586
E + +++ E + L E E + R EEL + + RI L+ +
Sbjct: 1187 ---SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI-SLKLANED 1242
Query: 587 KDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMD 646
K+ L +EE +A + ++ +R A EL LR Q++ +D
Sbjct: 1243 KEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMK---------MLD 1293
Query: 647 FEKSRSQREQEE 658
E +R RE E
Sbjct: 1294 SENTRLGRELAE 1305
Score = 88.2 bits (217), Expect = 2e-17
Identities = 131/478 (27%), Positives = 203/478 (42%), Gaps = 63/478 (13%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
EAE Q + E L L EK+ L++E A L++ R EG LLL +
Sbjct: 1010 EAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQE--RDEG----------LLLAE 1057
Query: 243 SQLEQ---LQEE-----NFRLESGREDERLRCAELEREVAELQHRNQ-------ALTSLA 287
S+ +Q L+E + +L R E+ER+ + Q R + ALTS
Sbjct: 1058 SEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSEL 1117
Query: 288 QEAQALKDEM-----DELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHA 342
++ +A ++E E+R+ E+A L SC R E ELR Q+R LE+ G
Sbjct: 1118 RDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLR---EAEELRTQLRLLEDARDGLR 1174
Query: 343 ERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTK 402
+ + +LR + R E QR++ EL+ E A + E R E+ S K
Sbjct: 1175 RELLEAQRKLRESQEGR---EVQRQEAGELRRSLGEGAKERE----ALRRSNEELRSAVK 1227
Query: 403 EKERLLAERDSLREANE--ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPA----- 455
+ E +ER SL+ ANE E + A L+ T T + + L A
Sbjct: 1228 KAE---SERISLKLANEDKEQKLALLE-EARTAVGKEAGELRTGLQEVERSRLEARRELQ 1283
Query: 456 ELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRA 515
ELR + L EN RL R+ A + R +R +++ R GL + + L +R
Sbjct: 1284 ELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQ 1343
Query: 516 QVEDLQKALQEQGG--KTEDSILL----KRKLEEHLQKLHEADLELQRKREYIEELEPPT 569
+++ Q+ LQEQ G +T + LL + + E Q H LEL+ + E E
Sbjct: 1344 ELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGL 1403
Query: 570 DSSTAR-RIEELQHNLQKKDADLRAMEER---YRRYVDKARMVMQTMEPKQRPAAGAP 623
S A R + L+ L + + RA E + R + + + + P RP G+P
Sbjct: 1404 RLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSP 1461
Score = 85.1 bits (209), Expect = 2e-16
Identities = 130/553 (23%), Positives = 226/553 (40%), Gaps = 62/553 (11%)
Query: 182 EEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLL 241
+ ++G +++ RQL L ++ LA+E +RE + R + +L
Sbjct: 649 DAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSR---------ATLQRDML 699
Query: 242 QSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALT----SLAQEAQALK--- 294
Q++ ++ E + E+GR + L +L E A LQ L+ SLAQ+ L
Sbjct: 700 QAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759
Query: 295 ---DEMDELRQSSERAGQLEATLT-SCRRRLGELRELRRQVRQLEERNAGHAERTRQ-LE 349
+E Q +R + EAT+ + RL ELR + RQ E + AE+ ++ LE
Sbjct: 760 AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819
Query: 350 DELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLA 409
+L R+QL+ Q Q+ R++E +A + E + E E +EKE L
Sbjct: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARR---EAQRQVEALERAAREKEALAK 876
Query: 410 ERDSL-----------REANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAA--EILPAE 456
E L R +EE +L+ L + SL + L A E L AE
Sbjct: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL---EGSLFEVQRQLAQLEARREQLEAE 933
Query: 457 LRETLLRLQ--------LENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQ 508
+ LL + L + + QE A +++ Q+ ++ A+ L Q +++
Sbjct: 934 GQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEE 993
Query: 509 QLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPP 568
L L+ + E + L+ + + + L+R+ EE L +L + E + E I L+
Sbjct: 994 DLQRLQREKEAAWRELEAERAQLQSQ--LQREQEELLARL---EAEKEELSEEIAALQQE 1048
Query: 569 TDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHS 628
D E Q L K+++ A+ E+ + ME ++R A + S
Sbjct: 1049 RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
Query: 629 LRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSF 688
L +R L E++ + QE + L ++G +QR + A+
Sbjct: 1109 TVNALTS---ELRDLRAQREEAAAAHAQEVRRLQEQARDLG---KQR---DSCLREAEEL 1159
Query: 689 LAQQRLATNSRRG 701
Q RL ++R G
Sbjct: 1160 RTQLRLLEDARDG 1172
Score = 83.6 bits (205), Expect = 6e-16
Identities = 136/530 (25%), Positives = 220/530 (41%), Gaps = 89/530 (16%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
L E DEL+ + L RQL + E+ S L++ + E E +L
Sbjct: 1518 LRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVA--ESEEARRSVDGRLS 1575
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
+Q++L LQE ES R ER R A L+ +VA L+ QA S E
Sbjct: 1576 GVQAEL-ALQE-----ESVRRSERERRATLD-QVATLERSLQATES-------------E 1615
Query: 300 LRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRA---- 355
LR S E+ +++A T G+ R L+ + E R + R LE EL+R+
Sbjct: 1616 LRASQEKISKMKANETKLE---GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGL 1672
Query: 356 GSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLR 415
AQ +A + +V LQ Q + +KA +E ++ K +E A RD +R
Sbjct: 1673 SDREAQAQALQDRVDSLQRQVADSEVKAGTLQL---TVERLNGALAKVEESEGALRDKVR 1729
Query: 416 EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQE 475
E L Q+ SL+ T +L + E +L+ +L+ R E
Sbjct: 1730 GLTE----------ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSE 1779
Query: 476 AADR-----ERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGK 530
A + E+ + L+ + D R E Q QQL E+ Q ++ + A K
Sbjct: 1780 ARKQSSSLGEQVQTLRGEVADLELQRVEAEGQ----LQQLREVLRQRQEGEAAALNTVQK 1835
Query: 531 TEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEE----LQHNLQK 586
+D +R L+E L L A +L+ ++ +E +A R+E+ L+ L K
Sbjct: 1836 LQDE---RRLLQERLGSLQRALAQLEAEKREVER--------SALRLEKDRVALRRTLDK 1884
Query: 587 KDAD-LRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRI----- 640
+ + LR+ E+ R +K R+ R GA EL + Q+++ + ++
Sbjct: 1885 VEREKLRSHEDTVRLSAEKGRL--------DRTLTGAELELAEAQRQIQQLEAQVVVLEQ 1936
Query: 641 ----RHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQ 686
LE+D ++ + + +QE + L SA A +R E R AH Q
Sbjct: 1937 SHSPAQLEVDAQQQQLELQQEVERLRSA-----QAQTERTLEARERAHRQ 1981
Score = 82.0 bits (201), Expect = 2e-15
Identities = 136/575 (23%), Positives = 226/575 (39%), Gaps = 88/575 (15%)
Query: 183 EAEEGDELQQRCLDLERQLM-------LLSEEKQSLAQENAGLR----ERMGRPEGEGTP 231
E E+G+ LQQ DL + ++ LS +++ N LR +R P +P
Sbjct: 442 ETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSP 501
Query: 232 G-------------LTAKKLLLLQSQLE----QLQEENFRLESGRE-----DERLRCAEL 269
G + L L+ S L Q+Q+ R E+ ++ ++L +E
Sbjct: 502 GRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSES 561
Query: 270 EREVAE--LQHRNQALTSLAQEAQALKDEMDELRQSSE----RAGQLEATLTSCRRRLGE 323
ER E LQ Q + + E+ LR ++E L +L +++ E
Sbjct: 562 ERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEE 621
Query: 324 LRELRRQVRQLEERNAGHAER-TRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMK 382
LR+ R +++ +E +R + ED ++ +R +LE RQ+++L+G+R A
Sbjct: 622 LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLA-- 679
Query: 383 AEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCA----QLQPRGLTQADPSL 438
K L E R E T +++ L AE+ + EA + +L L + SL
Sbjct: 680 --KELVEVR---EALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASL 734
Query: 439 DPT---------STPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHL 489
+ S D L L A+L E LQ ++ ++ RE QE L+
Sbjct: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELR 794
Query: 490 EDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLH 549
+ AR GLE R+ +Q L Q+ L+ E+ E L R+L Q+L
Sbjct: 795 LEQEVARQGLEGSLRVAEQAQEALEQQLPTLR---HERSQLQEQLAQLSRQLSGREQELE 851
Query: 550 EADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVM 609
+A E QR+ E +E AR E L L A E R ++A +
Sbjct: 852 QARREAQRQVEALER--------AAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLR 903
Query: 610 QTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMG 669
E + L ++ QL + + R LE + + +E L +
Sbjct: 904 LEKEALE-------GSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQI- 955
Query: 670 MALQQRAGEER---------APAHAQSFLAQQRLA 695
+A Q++A ++ A AQ+ L +QR A
Sbjct: 956 IATQEKASLDKELMAQKLVQAEREAQASLREQRAA 990
Score = 80.9 bits (198), Expect = 4e-15
Identities = 110/436 (25%), Positives = 195/436 (44%), Gaps = 74/436 (16%)
Query: 132 IQRIMTLEESVQHVVME--AIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGD- 188
+ ++ TLE S+Q E A QE ++K + E RR + + +E
Sbjct: 1599 LDQVATLERSLQATESELRASQEKISKMKANETKLE------GDKRRLKEVLDASESRTV 1652
Query: 189 --ELQQRCLD--LERQLMLLSEEK---QSLAQENAGLRERMGRPEGE-GTPGLTAKKLLL 240
ELQ+R L+ L+R + LS+ + Q+L L+ ++ E + GT LT ++L
Sbjct: 1653 KLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERL-- 1710
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREVAELQ-------HRNQALTSLAQEAQAL 293
L +++E L R+ R L + A L H +ALT+ + Q L
Sbjct: 1711 -NGALAKVEESEGAL---RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL 1766
Query: 294 KDEMDELRQSSERAGQLEATLTSCRRRL---------------GELRELRRQVRQLEERN 338
++ +D RQ+ A + ++L + L G+L++LR +RQ +E
Sbjct: 1767 QERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGE 1826
Query: 339 AGHAERTRQLEDELR----RAGSLR---AQLEAQRRQVQELQGQRQEEAMKAEKWLFECR 391
A ++L+DE R R GSL+ AQLEA++R+V + A++ EK R
Sbjct: 1827 AAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREV-------ERSALRLEKDRVALR 1879
Query: 392 NLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAE 451
+K E+E+L + D++R + E+ R R LT A+ L + L A+
Sbjct: 1880 RTLDKV-----EREKLRSHEDTVRLSAEKGRL----DRTLTGAELELAEAQRQIQQLEAQ 1930
Query: 452 ILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLS 511
++ E + +L+++ + E Q+E++R + LE + R ++Q++
Sbjct: 1931 VVVLEQSHSPAQLEVD------AQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVR 1984
Query: 512 ELRAQVEDLQKALQEQ 527
L QV L+ LQ++
Sbjct: 1985 GLEEQVSTLKGQLQQE 2000
Score = 78.2 bits (191), Expect = 2e-14
Identities = 132/510 (25%), Positives = 211/510 (41%), Gaps = 89/510 (17%)
Query: 180 LSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
LS+ + + L Q LDL R + L EEK + L+ R + E E T
Sbjct: 738 LSKLSALNESLAQDKLDLNRLVAQLEEEK-------SALQGRQRQAEQEATVAREE---- 786
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDE 299
Q +LE+L+ E G E LR AE +E E Q L +L E L++++ +
Sbjct: 787 --QERLEELRLEQEVARQGLEGS-LRVAEQAQEALE-----QQLPTLRHERSQLQEQLAQ 838
Query: 300 L-RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAG-- 356
L RQ S R +LE +R++ L R+ L + +AG A + E E R
Sbjct: 839 LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898
Query: 357 SLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLRE 416
+ R +LE + + + QRQ ++A + LE + +++ KE L E LR
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARR-----EQLEAEGQALLLAKETLTGELAGLR- 952
Query: 417 ANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEA 476
Q TQ SLD + +A +++ AE RE L+ Q A
Sbjct: 953 ----------QQIIATQEKASLDK-----ELMAQKLVQAE-REAQASLR-------EQRA 989
Query: 477 ADRERQEELQRHLEDANR----ARHGLETQHRLNQQQ-LSELRAQVEDLQKALQEQGGKT 531
A E + LQR E A R R L++Q + Q++ L+ L A+ E+L + + +
Sbjct: 990 AHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQER 1049
Query: 532 EDSILLKRKLEEHLQKLHEAD-------------------LELQRKREYIEELEPPTDSS 572
++ +LL ++ L E++ LE++R++ + + S+
Sbjct: 1050 DEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRST 1109
Query: 573 TARRIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
EL+ +++ A + RR ++AR + KQR + E LRTQ
Sbjct: 1110 VNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDL-----GKQRDS--CLREAEELRTQ 1162
Query: 633 LR----ERDVRIRHLEMDFEKSRSQREQEE 658
LR RD R L E R RE +E
Sbjct: 1163 LRLLEDARDGLRREL---LEAQRKLRESQE 1189
Score = 53.5 bits (127), Expect = 7e-07
Identities = 123/563 (21%), Positives = 208/563 (36%), Gaps = 89/563 (15%)
Query: 160 DSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEE---KQSLAQENA 216
+ L ++ D + +Y +SE E+ L+ L+ + L+ + ++ L +E A
Sbjct: 94 EDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQA 153
Query: 217 GLRERM-GRPEGEGTPGLTAKKLL--LLQ-----SQLEQ-LQEENFRLESGREDERLRCA 267
R ++ EG+ ++L +LQ S+LEQ L E + LE R +
Sbjct: 154 SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQ 213
Query: 268 ELEREVAELQHRNQALTSLAQEAQALKDEMDELRQS----SERAGQLEATLTSCRRRLGE 323
+LE + L+ Q SLAQ L++++D+ + SE ++ T CR+ L E
Sbjct: 214 DLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKEL-E 272
Query: 324 LREL--RRQVRQLEERNAGHAERT----RQLEDELRRAGSLRAQLEAQRRQVQELQGQRQ 377
RE RR+ + R RQ+ R ++ E Q+ +
Sbjct: 273 HREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTS 332
Query: 378 EEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPS 437
+A L L E EK+ LL + E+LR L+ + L Q
Sbjct: 333 RAVQEAGLGLSTGLRLAESRAEAALEKQALLQ-----AQLEEQLRDKVLREKDLAQ---- 383
Query: 438 LDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARH 497
+ +++ A+L + L L KRL +Q + ++L LE R
Sbjct: 384 --------QQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR- 434
Query: 498 GLETQHRLNQQQLSELRAQVEDLQKAL---QEQGGKTEDSILLKRKLEEHLQKLHEADLE 554
L+ Q L + L+ + DL +A+ E G + S L+ L
Sbjct: 435 -LQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTP 493
Query: 555 LQRKREYIEELEPP--------TDSSTARRIEELQH------------------------ 582
+R P +DSST I H
Sbjct: 494 SPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLR 553
Query: 583 -NLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ----LRERD 637
L +++ RA+EE+ +R DK MQ E QR E+ LR+ RE+
Sbjct: 554 KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQR-------EVQRLRSANELLSREKS 606
Query: 638 VRIRHLEMDFEKSRSQREQEEKL 660
L++ +++ R++ EKL
Sbjct: 607 NLAHSLQVAQQQAEELRQEREKL 629
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 88.2 bits (217), Expect = 2e-17
Identities = 88/449 (19%), Positives = 207/449 (46%), Gaps = 44/449 (9%)
Query: 241 LQSQLEQLQEENFRLESGREDERLRCAELEREV-------------AELQHRNQALTSLA 287
L+ + +LQE+ +ES + + +L EL+R++ AE H + L S++
Sbjct: 280 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 339
Query: 288 QEAQALKDEMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQ 347
+ QA +E + + +++ + R+ +++E ++++ EE+ E+ R+
Sbjct: 340 AKLQAQVEENELWNRLNQQQEE------KMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE 393
Query: 348 LEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFE----CRNLEEKYESVTK- 402
E+++RR + + E + R+ +E+ +++E+ + E+ ++E R LEEK K
Sbjct: 394 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKI 453
Query: 403 -EKERLLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETL 461
E+E E + +RE + Q Q + + + + + ++ E E +
Sbjct: 454 REQEEKRQEEEKIREQEKR----QEQEAKMWRQEEKIREQEEKIREQEEKMWRQE--EKI 507
Query: 462 LRLQLENKRLCRQEAADRERQEELQRHLEDANRAR---HGLETQHRLNQQQLSELRAQVE 518
+ + RQE + RQEE R E+ R + H E + R ++++ ++
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 519 DLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTAR--- 575
D ++ ++EQ K + K+ E +K+ E + +++ + E +E E +
Sbjct: 568 DQEEKIREQEEKVWRQ---EEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 624
Query: 576 ---RIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQ 632
+++E + +++++ +R E++ R +K R + M+ ++ ++ +
Sbjct: 625 QEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
Query: 633 LRERDVRIRHLEMD-FEKSRSQREQEEKL 660
++E++ ++R E +E+ R+QEEK+
Sbjct: 685 MQEQEEKMRRQEEKMWEQEVRLRQQEEKM 713
Score = 70.9 bits (172), Expect = 4e-12
Identities = 73/382 (19%), Positives = 175/382 (45%), Gaps = 47/382 (12%)
Query: 183 EAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQ 242
E EE Q+ + + ++M EEK +E +E R + E + +
Sbjct: 386 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE--------MMWEKE 437
Query: 243 SQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQ 302
++ +L+E+ E RE E R + E ++ E + R + + ++ + ++++ +++R+
Sbjct: 438 EKIRELEEKMHEQEKIREQEEKR--QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 495
Query: 303 SSERAGQLEATLTSCRRRLGELRELRRQV-RQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
E+ + E ++ E ++R + RQ +E E+ R+ E+ R+ + Q
Sbjct: 496 QEEKMWRQE-------EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQ 548
Query: 362 LEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEEL 421
E R+Q +++ RQEE M ++ + E+ E V +++E++ + + +RE E++
Sbjct: 549 EEKIRKQEEKMW--RQEEKMHDQE-----EKIREQEEKVWRQEEKIREQEEKIREQEEKI 601
Query: 422 RCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRER 481
R + + T + + + ++ E ++Q + +++ RQE RE+
Sbjct: 602 REQE-------------EMTQEQEEKMGEQ--EEKMCEQEEKMQEQEEKMRRQEEKIREQ 646
Query: 482 QEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRKL 541
+++++ E ++ Q +Q ++ Q E +Q+ QE+ + ++ K+
Sbjct: 647 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE--QEEKMRRQE-----EKM 699
Query: 542 EEHLQKLHEADLELQRKREYIE 563
E +L + + ++Q +E++E
Sbjct: 700 WEQEVRLRQQEEKMQEHQEHLE 721
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 87.8 bits (216), Expect = 3e-17
Identities = 115/581 (19%), Positives = 246/581 (42%), Gaps = 66/581 (11%)
Query: 141 SVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAEEGDELQQRCLDLERQ 200
S H + E +TK+ D+LS E Y N + +EL+++ +L+ +
Sbjct: 151 STWHKKADRYIEELTKER-DALSLELYRNTITN--------------EELKKKNAELQEK 195
Query: 201 LMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQLQEENFRLESGRE 260
L L EK + L+ ++ R K LL Q Q LQEE +R E
Sbjct: 196 LRLAESEKSEIQLNVKELKRKLERA-----------KFLLPQVQTNTLQEEMWRQEEELR 244
Query: 261 DERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSCRRR 320
++ + + E ++ + R L ++ ++++ +++R+ +R + E L +
Sbjct: 245 EQEKKIRKQEEKMWRQEER------LREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298
Query: 321 LGELRELRRQVRQLEERNAG---HAERTRQLEDEL-RRAGSLRAQLEAQRRQVQELQGQR 376
L E ++LR Q Q++E+ E+ R+ E+++ R+ L Q + R Q Q+++ Q
Sbjct: 299 LREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 358
Query: 377 Q------------EEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELR-- 422
+ EE M+ ++ ++E ++ E + + ++++ E +++RE E+++
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ 418
Query: 423 ----CAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLE----NKRLCRQ 474
Q + Q P + + + +E +R Q E K++ RQ
Sbjct: 419 EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 478
Query: 475 EAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDS 534
E RE+++++ E + Q +Q LR + E +++ Q++ + E+
Sbjct: 479 EKM-REQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMRE--QKKMWQQEEK 535
Query: 535 ILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAM 594
+ ++K +E +K + + E R+ E + E E + E + +Q+++ +R
Sbjct: 536 MREEKKTQEQEKKTWDQE-EKMREEERMREREKKMREEE-EMMREQEEKMQEQEEKMREQ 593
Query: 595 EERYRRYVDKARMVMQTMEPKQRPAAGAPPE--LHSLRTQLRERDVRIRHLEMD-FEKSR 651
EE+ +K + + M ++ E + + E++ +++ E +E+
Sbjct: 594 EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEE 653
Query: 652 SQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
REQEEK+ G + R EE+ + Q+
Sbjct: 654 KMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQE 694
Score = 81.6 bits (200), Expect = 2e-15
Identities = 98/487 (20%), Positives = 215/487 (44%), Gaps = 46/487 (9%)
Query: 185 EEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQ 244
E+ EL+++ +L Q L +E+Q QE + E E ++L + Q
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 245 LEQLQEENFRLESGR---EDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELR 301
+ + QE+ R + R +DERLR E E + E Q + QE + +++ ++R
Sbjct: 347 MRE-QEQKMRDQEERMWEQDERLR--EKEERMRE-QEKMWEQEEKMQEEERIREREKKMR 402
Query: 302 QSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQ 361
+ E + E + + E E Q ++L E+ E+ + E E + +
Sbjct: 403 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIW-----E 457
Query: 362 LEAQRRQVQELQGQ-----RQEEAMKAEKWLFECRN-LEEKYESVTKEKERLLAERDSLR 415
E + R +E+ GQ RQE+ + E ++E + ++ + + ++ER+ + + LR
Sbjct: 458 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR 517
Query: 416 EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQE 475
E E +R Q + Q + + T ++RE R++ K++ +E
Sbjct: 518 EKEERMR---EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE-RMREREKKMREEE 573
Query: 476 AADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSI 535
RE++E++Q E + Q Q+Q ++ Q E + + +E + ++ +
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM 633
Query: 536 LLKR--KLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRA 593
+ ++ K++E +K+ E + +++ + E + E E +++ + +++++ ++
Sbjct: 634 MWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE--------EKMQGQEEKMREQEEKMQG 685
Query: 594 MEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQ 653
EE+ R +K R + M ++ G ++ + ++RE++ RI
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWG-QEEMREKEERI------------- 731
Query: 654 REQEEKL 660
R+Q+EK+
Sbjct: 732 RDQKEKM 738
Score = 58.2 bits (139), Expect = 3e-08
Identities = 69/398 (17%), Positives = 172/398 (43%), Gaps = 51/398 (12%)
Query: 182 EEAEEGDELQQRCLDL--ERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLL 239
E+ +E + +++R + E + M EEK +EN +E + L +K
Sbjct: 386 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR----LPEQKEK 441
Query: 240 LLQSQLEQLQEENFRLESGREDERLRCAE----LEREVAELQHRNQALTSLAQEAQALKD 295
L + + Q QEE ++E++R E E+++ + + + ++ + ++D
Sbjct: 442 LWEQEKMQEQEEKI----WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 497
Query: 296 EMDELRQSSERAGQLEATLTSCRRRLGELRELRRQVRQL---------EERNAGHAERTR 346
+ ++ ER + + L R+ E +++ +Q ++ E++ E+ R
Sbjct: 498 QEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMR 557
Query: 347 QLEDELRRAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKER 406
+ E R +R + E R Q +++Q QEE M+ ++ + E+ E + +++E+
Sbjct: 558 EEERMREREKKMREEEEMMREQEEKMQ--EQEEKMREQE-----EKMWEQEEKMQEQEEK 610
Query: 407 LLAERDSLREANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQL 466
+ + + + E EE + + + Q + +++E ++
Sbjct: 611 MWEQEEKMWEQEEEDKMQEQEEMMWEQEE--------------------KMQEQEEKMWE 650
Query: 467 ENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQE 526
+ +++ QE RE++E++Q E ++ Q ++Q ++R Q E + ++
Sbjct: 651 QEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEK 710
Query: 527 QGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEE 564
G+ E+ + + ++ E +++ + ++Q + EE
Sbjct: 711 MWGQ-EEKMWGQEEMREKEERIRDQKEKMQERLPEHEE 747
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/258 (20%), Positives = 121/258 (46%), Gaps = 16/258 (6%)
Query: 173 QSRRYYFLSEEAEEGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPG 232
Q R + E E +E + + +Q + EEK++ QE + E E
Sbjct: 505 QEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE 564
Query: 233 LTAKKLLLLQSQLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQA 292
K ++ + E ++E+ +++ E R + ++ + ++Q + + + +E
Sbjct: 565 REKK----MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE-QEEKMW 619
Query: 293 LKDEMDELRQSSERAGQLEATLTSCRRRLGE----LRELRRQVRQLEERNAGHAERTRQL 348
++E D++++ E + E + ++ E +RE ++R+ EE+ G E+ R+
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679
Query: 349 EDELR-RAGSLRAQLEAQRRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERL 407
E++++ + +R Q E R Q +++ GQ +E+ E+ ++ + EK E + +KE++
Sbjct: 680 EEKMQGQEEKMREQEEKMRGQEEKMWGQ-EEKMWGQEEKMWGQEEMREKEERIRDQKEKM 738
Query: 408 LAERDSLREANEELRCAQ 425
++ L E E RC++
Sbjct: 739 ---QERLPEHEE--RCSE 751
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 87.4 bits (215), Expect = 4e-17
Identities = 105/481 (21%), Positives = 216/481 (44%), Gaps = 64/481 (13%)
Query: 188 DELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQLEQ 247
+EL+++ +L+ +L L+ EK + L+ + L K+ L Q +
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRK-----------LETDKIPLPQEGQVR 55
Query: 248 LQEENFRLESG--REDE-RLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSS 304
QE R + G RE E ++R E + E Q R Q QE Q + E Q
Sbjct: 56 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE----GQVR 111
Query: 305 ERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELR-RAGSLR---A 360
E+ GQ+ R + G++RE QVR+ E + + R+ E ++R + G +R
Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 171
Query: 361 QLEAQRRQVQELQGQ-RQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANE 419
Q+ Q QV+E +GQ R++E E+ + E+ E + +++E++ + + + E E
Sbjct: 172 QVREQEGQVREQEGQVREQEGQMGEQE----GQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227
Query: 420 ELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADR 479
++R + Q + ++++ ++Q + +++ +QE R
Sbjct: 228 QMRKQEEQMGEQEE----------------------QVQKQEEQVQKQEEQMRKQEEQMR 265
Query: 480 ERQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKR 539
E++E+++ E + + E + + +Q+ ++R Q E +++ +EQ + E+ + R
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQEEQTGEQE-EQMREQEEQMREQ-EEQMREQEEQM---R 320
Query: 540 KLEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYR 599
+ EE + K E E +K + E+ E ++ E + +QK++ +R EE+ R
Sbjct: 321 EQEEQMGKQEEQMWE--QKEQMWEQKEQMWKQE--EQMGEQEEQMQKQEEQVRKQEEQMR 376
Query: 600 RYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEK 659
+ ++ R + M ++ ++ + Q+RE++ E E+ R+QEE
Sbjct: 377 KQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQE------EQMGEQKEQMRKQEEH 430
Query: 660 L 660
+
Sbjct: 431 M 431
Score = 80.5 bits (197), Expect = 5e-15
Identities = 84/452 (18%), Positives = 199/452 (44%), Gaps = 36/452 (7%)
Query: 246 EQLQEENFRLESGREDERLRCAELEREVAELQHRNQA-LTSLAQEAQALKDEMDELRQSS 304
E+L+E+N L+ + +E++ + EL+ + + L QE Q + E Q
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQE----GQVR 62
Query: 305 ERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEA 364
E+ GQ+ R + G++RE QVR+ E + + R+ E ++R Q+
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ---EGQVRE 119
Query: 365 QRRQVQELQGQRQEEAMKAEKWLFECRNLE---EKYESVTKEKERLLAERDS-LREANEE 420
Q QV+E +GQ +E+ + + + R E + E +E+E + E++ +RE +
Sbjct: 120 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 179
Query: 421 LRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRE 480
+R + Q R + + + ++ E ++ + +++ +QE E
Sbjct: 180 VREQEGQVR---EQEGQMGEQE------------GQMGEQEEQMGEQEEQMQKQEEQMGE 224
Query: 481 RQEELQRHLEDANRARHGLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDSILLKRK 540
++E++++ E ++ Q Q+Q ++R Q E +++ +EQ + E+ +L +++
Sbjct: 225 QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQ-EEQMREQEEQMLKQKE 283
Query: 541 LEEHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQHNLQKKDADLRAMEERYRR 600
E ++ E + +++ + E + E E ++ E + +++++ + EE+
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQMREQE--------EQMREQEEQMREQEEQMGKQEEQMWE 335
Query: 601 YVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRERDVRIRHLEMDFEKSRSQREQEEKL 660
++ + M ++ ++ Q+R+++ ++R E K Q ++E+
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQ 395
Query: 661 LISAWYNMGMALQQRAGEERAPAHAQSFLAQQ 692
+ MG +Q +E + + +Q
Sbjct: 396 MGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQ 427
Score = 73.9 bits (180), Expect = 5e-13
Identities = 93/438 (21%), Positives = 204/438 (46%), Gaps = 24/438 (5%)
Query: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
++K +Q + L E+ + + I+EL K D + G Q + +
Sbjct: 10 KEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVR 69
Query: 186 EGD-ELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRP-EGEGTPGLTAKKLLLLQS 243
E + +++++ + Q + E++ + ++ +RE+ G+ E EG ++ +
Sbjct: 70 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 244 QLEQLQEENFRLESG--REDE-RLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDEL 300
Q+ + QE R + G RE E ++R E + E Q R Q QE Q ++++ ++
Sbjct: 130 QVRE-QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ-VREQEGQV 187
Query: 301 RQSSERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRA 360
R+ + G+ E + ++GE E Q+++ EE+ E+ R+ E+++ G
Sbjct: 188 REQEGQMGEQEGQMGEQEEQMGEQEE---QMQKQEEQMGEQEEQMRKQEEQM---GEQEE 241
Query: 361 QLEAQRRQVQ--ELQGQRQEEAMKAEKWLFECRNLEE---KYESVTKEKERLLAERDSLR 415
Q++ Q QVQ E Q ++QEE M+ ++ + R EE K + T+++E+ + + +R
Sbjct: 242 QVQKQEEQVQKQEEQMRKQEEQMREQEE--QMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299
Query: 416 EANEELRCAQLQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQE 475
E E++R + Q R + + + E ++ E ++ + +++ QE
Sbjct: 300 EQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE-QKEQMWEQKEQMWKQEEQMGEQE 358
Query: 476 AADRERQEELQRHLEDANRARHGL---ETQHRLNQQQLSELRAQVEDLQKALQEQGGKTE 532
++++E++++ E + + E Q R ++Q+ E + Q+ + ++ ++EQ +
Sbjct: 359 EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMG 418
Query: 533 DSILLKRKLEEHLQKLHE 550
+ RK EEH+ + E
Sbjct: 419 EQKEQMRKQEEHMGEQKE 436
Score = 38.5 bits (88), Expect = 0.022
Identities = 46/249 (18%), Positives = 106/249 (42%), Gaps = 19/249 (7%)
Query: 456 ELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARHGLETQHRLNQQQLSELRA 515
EL+E LQ E + + +++ + +EL+R LE ++ E Q R + Q+ E
Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLE-TDKIPLPQEGQVREQEGQVREQEG 66
Query: 516 QVEDLQKALQEQGGKTEDSILLKRKLEEHLQKLHEADLELQRKREYIEELEPPTDSSTAR 575
QV + + ++EQ G+ + + ++ E ++ E + +++ + + E E
Sbjct: 67 QVREQEGQVREQEGQVREQ---EGQVREQEGQVREQEGQVREQEGQVREQEG-------- 115
Query: 576 RIEELQHNLQKKDADLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAPPELHSLRTQLRE 635
++ E + +++++ +R E + R + R E + R G ++ Q+RE
Sbjct: 116 QVREQEGQVREQEGQVREQEGQVREQEGQVR----EQEGQVREQEG---QVREQEGQVRE 168
Query: 636 RDVRIRHLEMDFEKSRSQREQEEKLLISAWYNMGMALQQRAGEERAPAHAQSFLAQQRLA 695
++ ++R E + Q ++E + MG +Q +E + + +Q
Sbjct: 169 QEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ 228
Query: 696 TNSRRGPLG 704
+ +G
Sbjct: 229 MRKQEEQMG 237
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,320,670
Number of Sequences: 37866
Number of extensions: 1316591
Number of successful extensions: 18662
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 387
Number of HSP's successfully gapped in prelim test: 1098
Number of HSP's that attempted gapping in prelim test: 6742
Number of HSP's gapped (non-prelim): 5192
length of query: 717
length of database: 18,247,518
effective HSP length: 110
effective length of query: 607
effective length of database: 14,082,258
effective search space: 8547930606
effective search space used: 8547930606
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.