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Search of human proteins with 153792144
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|153792144 ATP-binding cassette, sub-family A, member 10
[Homo sapiens]
(1543 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 3085 0.0
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 1928 0.0
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 1883 0.0
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 1794 0.0
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 1189 0.0
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 1189 0.0
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 325 2e-88
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 302 2e-81
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 294 5e-79
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 294 5e-79
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ... 277 5e-74
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 277 5e-74
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 277 5e-74
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 274 6e-73
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 250 9e-66
gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens] 120 8e-27
gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens] 120 8e-27
gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens] 120 8e-27
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap... 92 4e-18
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 89 3e-17
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 89 3e-17
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 89 3e-17
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 89 3e-17
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 89 3e-17
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 89 3e-17
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s... 83 2e-15
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa... 83 2e-15
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s... 81 9e-15
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 75 5e-13
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap... 74 1e-12
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 3085 bits (7998), Expect = 0.0
Identities = 1543/1543 (100%), Positives = 1543/1543 (100%)
Query: 1 MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIK 60
MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIK
Sbjct: 1 MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIK 60
Query: 61 EHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINM 120
EHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINM
Sbjct: 61 EHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINM 120
Query: 121 KIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSW 180
KIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSW
Sbjct: 121 KIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSW 180
Query: 181 GLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPML 240
GLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPML
Sbjct: 181 GLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPML 240
Query: 241 AGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFP 300
AGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFP
Sbjct: 241 AGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFP 300
Query: 301 DPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTH 360
DPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTH
Sbjct: 301 DPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTH 360
Query: 361 HEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG 420
HEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG
Sbjct: 361 HEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG 420
Query: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ
Sbjct: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
Query: 481 FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI 540
FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI
Sbjct: 481 FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI 540
Query: 541 AILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLS 600
AILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLS
Sbjct: 541 AILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLS 600
Query: 601 NGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYS 660
NGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYS
Sbjct: 601 NGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYS 660
Query: 661 LPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKI 720
LPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKI
Sbjct: 661 LPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKI 720
Query: 721 HVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLV 780
HVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLV
Sbjct: 721 HVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLV 780
Query: 781 LGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLV 840
LGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLV
Sbjct: 781 LGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLV 840
Query: 841 HSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIV 900
HSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIV
Sbjct: 841 HSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIV 900
Query: 901 SNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKK 960
SNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKK
Sbjct: 901 SNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKK 960
Query: 961 NVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCI 1020
NVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCI
Sbjct: 961 NVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCI 1020
Query: 1021 IGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFI 1080
IGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFI
Sbjct: 1021 IGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFI 1080
Query: 1081 PSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKY 1140
PSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKY
Sbjct: 1081 PSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKY 1140
Query: 1141 GNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASC 1200
GNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASC
Sbjct: 1141 GNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASC 1200
Query: 1201 LHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTA 1260
LHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTA
Sbjct: 1201 LHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTA 1260
Query: 1261 GVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSI 1320
GVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSI
Sbjct: 1261 GVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSI 1320
Query: 1321 SRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQ 1380
SRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQ
Sbjct: 1321 SRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQ 1380
Query: 1381 ILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIK 1440
ILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIK
Sbjct: 1381 ILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIK 1440
Query: 1441 MKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLE 1500
MKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLE
Sbjct: 1441 MKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLE 1500
Query: 1501 EYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQEDP 1543
EYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQEDP
Sbjct: 1501 EYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQEDP 1543
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 1928 bits (4994), Expect = 0.0
Identities = 966/1546 (62%), Positives = 1208/1546 (78%), Gaps = 15/1546 (0%)
Query: 1 MNKMALASFMKGRTVIGTPDEETMDIELPKKYH-EMVGVIFSDTFSYRLKFNWGYRIPVI 59
MNK+A A F+KGRT++G PDE++MD EL Y + V VIF+DTFSY LKF+WG+RIP++
Sbjct: 91 MNKVASAPFLKGRTIMGWPDEKSMD-ELDLNYSIDAVRVIFTDTFSYHLKFSWGHRIPMM 149
Query: 60 KEHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGIN 119
KEH +++ HC A++ ++ C +++W KGFVAFQAAINAAIIE+ TNHSVME+L SV G++
Sbjct: 150 KEHRDHSAHCQAVNEKMKCEGSEFWEKGFVAFQAAINAAIIEIATNHSVMEQLMSVTGVH 209
Query: 120 MKIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLS 179
MKI PF+++G + ++F F C++SFS+FIY+ S+NV +ER LMT+MGLRESAFWLS
Sbjct: 210 MKILPFVAQGGVATDFFIFFCIISFSTFIYYVSVNVTQERQYITSLMTMMGLRESAFWLS 269
Query: 180 WGLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPM 239
WGL Y FI IM+ MAL++ S IV TGF+++FTL+ LYGLSLI LAFLMSVLI+KP
Sbjct: 270 WGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSVLIKKPF 329
Query: 240 LAGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIF 299
L GL FL VFWG LGF LY +LP L W L LLSPFAFT GMAQ+ HLD ++
Sbjct: 330 LTGLVVFLLIVFWGILGFPALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLDYDVNSNAH 389
Query: 300 PDPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNT 359
D S + Y +IAT F+L FDTL YL+ TLYF+++LP + GH SPLFFLKS FW +H
Sbjct: 390 LDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRA 449
Query: 360 HHEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYE 419
+H + ENE + + + +D FEPVSPEF GKEAIRI+N+ KEY GK +VEAL+G+ FDIYE
Sbjct: 450 NHVVLENETDSDPTPNDCFEPVSPEFCGKEAIRIKNLKKEYAGKCERVEALKGVVFDIYE 509
Query: 420 GQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNF 479
GQITA+LGH+GAGK+TLLNILSGLSV T GS T+YN LS + D+E I K GFCPQ N
Sbjct: 510 GQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSRMADIENISKFTGFCPQSNV 569
Query: 480 QFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLG 539
QF FLTV+ENLR+FAKIKGI P EVE+EV+R++ EL+M++IQDI+A+ LSGGQ RKLT G
Sbjct: 570 QFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILAQNLSGGQNRKLTFG 629
Query: 540 IAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFL 599
IAILGDPQVLLLDEPTAGLDP SRHR+W+LLKE K DR+ILFSTQF+DEADILADRKVF+
Sbjct: 630 IAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEADILADRKVFI 689
Query: 600 SNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVY 659
SNGKLKCAGSSLFLK+KWGIGYHLSLH NE CD E ITSL+KQHI DAKLT +SEEKLVY
Sbjct: 690 SNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEEKLVY 749
Query: 660 SLPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEK 719
LPLE+TNKFP+LY DLD+CS+QGI +Y VS+T+LNEVFL LEGKS IDE D I Q +
Sbjct: 750 ILPLERTNKFPELYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESDIGIWGQLQ 809
Query: 720 IHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLL 779
++ G E+EQVL S ETRK +S ALWR+Q+ A+A +RFLKL++ER++L +LL
Sbjct: 810 TDGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLWTILL 869
Query: 780 VLGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDL 839
+ GI+FIP +LE + Y+ ++++ WE SP+ YFLS Q P+ PLT LL++N TGS I++
Sbjct: 870 LFGISFIPQLLEHLFYESYQKSYPWELSPNTYFLSPGQQPQDPLTHLLVINKTGSTIDNF 929
Query: 840 VHSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGI 899
+HSL+ Q+I +E+D F RNG+DDPSYNGAIIVSGD+KD+RFS+ACNTK+LNCFPVL+ +
Sbjct: 930 LHSLRRQNIAIEVDAFGTRNGTDDPSYNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDV 989
Query: 900 VSNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYK 959
+SN L+GIFN +E IQ + ++F + + + G+ + F + + +P+I MSSI DYK
Sbjct: 990 ISNGLLGIFNSSEHIQTDRSTFFEEHMDYEYGYRSNTFFWIPMAASFTPYIAMSSIGDYK 1049
Query: 960 KNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSW--ELMFVLV 1017
K SQL ISGL+PSAYW GQALVD+ LYFLIL + ++ Y IF ++ + + + + +
Sbjct: 1050 KKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLLMQIMDY-IFSPEEIIFIIQNLLIQI 1108
Query: 1018 VCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCM 1077
+C IG SL+FLTYV+SFIFR RKN+G WSF F I++I +Y L L
Sbjct: 1109 LCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIFSIVATDLNEYGFLGLFFGT 1168
Query: 1078 IFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLE 1137
+ IP FTL+G + + ++ + DS+D ++ + L LIPYL +IFLF++RCLE
Sbjct: 1169 MLIPPFTLIGSLFIFSEI----SPDSMDYLGASESEIVYLALLIPYLHFLIFLFILRCLE 1224
Query: 1138 MKYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVIT 1197
M ++M KDPVFRISPRS PNPEEPE E+ED+Q ER++ NA+ + +E PVI
Sbjct: 1225 MNCRKKLMRKDPVFRISPRSNAIFPNPEEPEGEEEDIQMERMRTVNAMAVRDFDETPVII 1284
Query: 1198 ASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTK 1257
ASCL KEY KK+CFS RKKKIA RNVSFCVKKGEV+GLLGHNGAGKST+IKMITG TK
Sbjct: 1285 ASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTK 1344
Query: 1258 PTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAA 1317
PTAG V+L+GS L FLGYCPQEN+LWP LT+++HLE+YAAVKGL K DA
Sbjct: 1345 PTAGQVILKGSGGG------EPLGFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAM 1398
Query: 1318 LSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQ 1377
++I+RLV+ALKLQ+QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEP TGMDPEGQQQ
Sbjct: 1399 IAITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQ 1458
Query: 1378 MWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLL 1437
MWQ+++AT +N ERG LLTTHYM+EAEAVCDR+A+MVSG LRCIGSIQHLK+KFG+DYLL
Sbjct: 1459 MWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLL 1518
Query: 1438 EIKMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTF 1497
E+K+K Q+E LH EIL+LFPQAA QER+SSLM YKLPVEDV PLS+AFFKLE +KQ+F
Sbjct: 1519 EMKLKNLAQMEPLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSF 1578
Query: 1498 NLEEYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQEDP 1543
+LEEYSLSQ+TLEQVFLEL KEQELG++++ D +V+WKLL QE+P
Sbjct: 1579 DLEEYSLSQSTLEQVFLELSKEQELGDLEEDFDPSVKWKLLLQEEP 1624
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 1884 bits (4879), Expect = 0.0
Identities = 958/1543 (62%), Positives = 1173/1543 (76%), Gaps = 18/1543 (1%)
Query: 1 MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIK 60
MNK ALA +KG +VIG P++ MD L + +G+IF++TFSY+L F GY P+ K
Sbjct: 90 MNKTALAPLLKGTSVIGAPNKTHMDEILLENLPYAMGIIFNETFSYKLIFFQGYNSPLWK 149
Query: 61 EHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINM 120
E +++ HCW +GE C L KYW +GFVA Q AIN AIIE+TTNH VMEEL SV I M
Sbjct: 150 E--DFSAHCWDGYGEFSCTLTKYWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITM 207
Query: 121 KIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSW 180
K PFI+K + NE F L+ FS +YF SLNV +ER K K LM +MGL++SAFWLSW
Sbjct: 208 KTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSW 267
Query: 181 GLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPML 240
GL Y FIFI+SIF+ ++IT I+ TGFMVIF L+ LYGLSL+AL FLMSVL++K +L
Sbjct: 268 GLIYAGFIFIISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVL 327
Query: 241 AGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFP 300
L FL T+FWGCLGFTV Y QLP SL W+L++ SPFAFT GM QI LD L+GVIFP
Sbjct: 328 TNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFP 387
Query: 301 DPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTH 360
DPSGDSY MIATF +L D L YL+ LYF+++LP D SPLFFL SS +HQ T+
Sbjct: 388 DPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTN 447
Query: 361 HEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG 420
++ E EI+ EH SDD FEPV+PEF GKEAIRIRNV KEY GK+GKVEAL+G+ FDIYEG
Sbjct: 448 AKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEG 507
Query: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
QITAILGH+GAGKS+LLNIL+GLSV TEGS TIYN LSE+ D+EEIRK G CPQFN Q
Sbjct: 508 QITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQ 567
Query: 481 FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI 540
FD LTV+ENL +FAKIKGI KEVEQEV+RI++ELDMQ+IQD +AK LS GQKRKLT GI
Sbjct: 568 FDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGI 627
Query: 541 AILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLS 600
ILGDPQ+LLLDEPT GLDPFSR +VWSLL+E + D +ILFSTQ MDEADILADRKV +S
Sbjct: 628 TILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMS 687
Query: 601 NGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYS 660
NG+LKCAGSS+FLKR+WG+GYHLSLHRNE+C+ E+ITS I HIPDAKL TE++EKLVY+
Sbjct: 688 NGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYT 747
Query: 661 LPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKI 720
LPLE+TN FPDL+SDLDKCSDQG+ Y +S+++LNEVF+ LEG+S I E DF E++
Sbjct: 748 LPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTI-EQDF-----EQV 801
Query: 721 HVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLV 780
+ R++ +EME S E + AVS LWR Q++A+A LRFLKL+R+ + LL LLLV
Sbjct: 802 EMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAMARLRFLKLKRQTKVLLTLLLV 861
Query: 781 LGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLV 840
GIA P+I+E IMY + E WEF +YFLS Q+P+ P TSLLI+NNT SNIED +
Sbjct: 862 FGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFI 921
Query: 841 HSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIV 900
SLK Q+I+LE+DDF NRNG+D SYNGAIIVSG QKDYRFSV CNTK+L+CFP+LM I+
Sbjct: 922 KSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNII 981
Query: 901 SNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKK 960
SN L+ +FN T+ I++ES+ F I L G DGS FL L+ +SP+I M SISDYKK
Sbjct: 982 SNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKK 1041
Query: 961 NVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQL-SWELMFVLVVC 1019
N +SQLWISGL+ SAYWCGQALVD+ + LIL ++LI+Y + + L + +++F LV+
Sbjct: 1042 NAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIV 1101
Query: 1020 IIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIF 1079
G A SL+F Y++SFIFRK RKN+G WSF FF + +I + ++ LI M+
Sbjct: 1102 TPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVL 1161
Query: 1080 IPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMK 1139
+PS+TLLG+ L D + E++ T L IPY Q+++F+FV+RC+E+K
Sbjct: 1162 VPSYTLLGFKTFLEVRD-QEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELK 1220
Query: 1140 YGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITAS 1199
G + M KDPVFRISP+SR+ PNPEEP +EDED+Q ER++ A ALT L+E+PVI AS
Sbjct: 1221 CGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIAS 1280
Query: 1200 CLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPT 1259
CLHKEY KKSCFS RKKKIA RN+SFCV++GE+LGLLG NGAGKS+SI+MI+G TKPT
Sbjct: 1281 CLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPT 1340
Query: 1260 AGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS 1319
AG V L+G + L LGYCPQEN LWP LT++EHLE+YAAVKGL K DA L+
Sbjct: 1341 AGEVELKGC--------SSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLA 1392
Query: 1320 ISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMW 1379
I+RLV A KL EQL PV+ L+ GI RKLCFVLS+LGN V+LLDEP TG+DP GQQQMW
Sbjct: 1393 IARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMW 1452
Query: 1380 QILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI 1439
Q +QA VKN ERG LLTTH ++EAEA+CDR+A+MVSG LRCIGSIQHLKNK G+DY+LE+
Sbjct: 1453 QAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILEL 1512
Query: 1440 KMKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNL 1499
K+KE +QV +HTEILKLFPQAA QERYSSL+ YKLPV DV+PLS+ F KLEA+K FNL
Sbjct: 1513 KVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNL 1572
Query: 1500 EEYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQED 1542
EEYSLSQ TLE+VFLEL KEQE+GN D++IDTT+ WKLLP D
Sbjct: 1573 EEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLLPHSD 1615
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 1794 bits (4646), Expect = 0.0
Identities = 918/1543 (59%), Positives = 1139/1543 (73%), Gaps = 51/1543 (3%)
Query: 1 MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIK 60
MNK+A F+ G+ V+G PDEE++ E+V V F++T+SY LKF G+ +P K
Sbjct: 90 MNKVASTPFLAGKEVLGLPDEESIKEFTANYPEEIVRVTFTNTYSYHLKFLLGHGMPAKK 149
Query: 61 EHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINM 120
EH ++T HC+ + +++C ++ +W +GFVA QAAINAAIIE+TTNHSVMEEL SV G NM
Sbjct: 150 EHKDHTAHCYETNEDVYCEVSVFWKEGFVALQAAINAAIIEITTNHSVMEELMSVTGKNM 209
Query: 121 KIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSW 180
K+ FI + ++ + + F+C++SFSSFIY+AS+NV RER + K LMT+MGLR+SAFWLSW
Sbjct: 210 KMHSFIGQSGVITDLYLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSW 269
Query: 181 GLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPML 240
GL Y FIFIM++F+ALVI S + +GFMV+F+L+ LYGLSL+ALAFLMS+L++K L
Sbjct: 270 GLLYAGFIFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFL 329
Query: 241 AGLAGFLFTVFWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFP 300
GL FL TVFWGCLGFT LYR LP SL W+LSLLSPFAF GMAQ+ HLD L+ FP
Sbjct: 330 TGLVVFLLTVFWGCLGFTSLYRHLPASLEWILSLLSPFAFMLGMAQLLHLDYDLNSNAFP 389
Query: 301 DPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTH 360
PS S ++AT F+LAFDT YL +YFE++LP++ GH PLFFLKSSFWS+ Q T
Sbjct: 390 HPSDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTD 449
Query: 361 HEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG 420
H E+E++ + S DSFE PEF GKEAIRIRNV KEY GK K+EAL+ + FDIYEG
Sbjct: 450 HVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEG 509
Query: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
QITAILGH+GAGKSTLLNILSGLSV T+GS TIYN +LSE+ D+E + K G CPQ N Q
Sbjct: 510 QITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQ 569
Query: 481 FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI 540
FDFLTVRENLR+FAKIKGI P+EV++E+
Sbjct: 570 FDFLTVRENLRLFAKIKGILPQEVDKEI-------------------------------- 597
Query: 541 AILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLS 600
LLDEPTAGLDPFSRH+VW+LLKE K DR+ILFSTQFMDEADILADRKVFLS
Sbjct: 598 --------FLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLS 649
Query: 601 NGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYS 660
GKLKCAGSSLFLK+KWGIGYHLSL NE+C E ITSL+KQHIPDAKL+ +SE KL+Y+
Sbjct: 650 QGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYT 709
Query: 661 LPLEKTNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKI 720
LPLE+TNKFP+LY DLD D GI NY VS+T+LNEVFL LEGKS I+E D I + +
Sbjct: 710 LPLERTNKFPELYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAILGEVQA 769
Query: 721 HVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLV 780
+T EMEQVL SL + RK + ALWR+QI A+A +R LKL+ ER+ALL LLL+
Sbjct: 770 EKADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKALLALLLI 829
Query: 781 LGIAFIPIILEKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLV 840
L F P+++E M K+ + ++ WE SP +YFL+ Q P PLT LLI+N TG++I+D +
Sbjct: 830 LMAGFCPLLVEYTMVKIYQNSYTWELSPHLYFLAPGQQPHDPLTQLLIINKTGASIDDFI 889
Query: 841 HSLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIV 900
S++ Q+I LE+D F RNG+DDPSYNGAI V ++K+Y FS+ACN K+LNCFPVLM IV
Sbjct: 890 QSVEHQNIALEVDAFGTRNGTDDPSYNGAITVCCNEKNYSFSLACNAKRLNCFPVLMDIV 949
Query: 901 SNALMGIFNFTELIQMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKK 960
SN L+G+ + I+ E ++F + +GF+ +F L++T+ P+I MSSI DYK
Sbjct: 950 SNGLLGMVKPSVHIRTERSTFLENGQDNPIGFLAYIMFWLVLTSSCPPYIAMSSIDDYKN 1009
Query: 961 NVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCI 1020
+SQL ISGL PSAYW GQALVD+ LYFL+ I+L+ Y L + + + C
Sbjct: 1010 RARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYLMSYISNFEDMLLTIIHIIQIPCA 1069
Query: 1021 IGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFI 1080
+G + SLIF+TYV+SFIFRK RKN+G WSF F+++ + + +E + I
Sbjct: 1070 VGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLI 1129
Query: 1081 PSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKY 1140
P T++G + L L F ++ L LIP+L +IFLF +RCLE K+
Sbjct: 1130 PPATMIGCLFLSSHLLFSSLFSE-----ERMDVQPFLVFLIPFLHFIIFLFTLRCLEWKF 1184
Query: 1141 GNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASC 1200
G + M KDP FRISPRS + NPEEPE EDEDVQ ERV+ ANAL + N +E+PVI ASC
Sbjct: 1185 GKKSMRKDPFFRISPRSSDVCQNPEEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASC 1244
Query: 1201 LHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTA 1260
L KEY +K CFS RK KIA RNVSFCV+KGEVLGLLGHNGAGKSTSIK+ITG TKPTA
Sbjct: 1245 LRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITGDTKPTA 1304
Query: 1261 GVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSI 1320
G V+L+GS ++L+FLGYCPQEN+LWP LT+++HLE+YAAVKGL K DA ++I
Sbjct: 1305 GQVLLKGSGGG------DALEFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAEVAI 1358
Query: 1321 SRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQ 1380
+RLV+ALKLQ+QLK+PVKTLSEGIKRKLCFVLSILGNPSVVLLDEP TGMDPEGQQQMWQ
Sbjct: 1359 TRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQ 1418
Query: 1381 ILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIK 1440
++AT +N ERG LLTTHYM+EAEAVCDR+A+MVSG LRCIGSIQHLK+KFG+DYLLE+K
Sbjct: 1419 AIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMK 1478
Query: 1441 MKEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLE 1500
+K QVE LH EIL+LFPQAA QERYSSLM YKLPVEDV PL++AFFKLE +KQ+F+LE
Sbjct: 1479 VKNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKLEKVKQSFDLE 1538
Query: 1501 EYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEWKLLPQEDP 1543
EYSLSQ+TLEQVFLEL KEQELG+ ++ D +V+WKLLPQE+P
Sbjct: 1539 EYSLSQSTLEQVFLELSKEQELGDFEEDFDPSVKWKLLPQEEP 1581
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 1189 bits (3075), Expect = 0.0
Identities = 669/1553 (43%), Positives = 966/1553 (62%), Gaps = 52/1553 (3%)
Query: 18 TPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIKEHSEYTEHCWAMHGEIF 77
T ++E + L K + VGV+F D+ SY L+F + IPV + + C
Sbjct: 110 TNEKEMLTSSLSKPSN-FVGVVFKDSMSYELRF-FPDMIPVSSIYMDSRAGCSKS----- 162
Query: 78 CYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFH 137
C A+YW GF QA+I+AAII++ TN S+ +EL S + M +
Sbjct: 163 CEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVIL 222
Query: 138 FTCLVSFSSFIYFASLNVARERGK-FKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMA 196
+++FS F YF ++++ E+ K K+ + +MGL ++AFWLSW L Y IF+MS+ MA
Sbjct: 223 IYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMA 282
Query: 197 LVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLG 256
++ T+ + + +VIF L+ LYGLS + A +++ L +K G+ F TV +G +G
Sbjct: 283 VIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIG 342
Query: 257 FTV-LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFFI 315
+ L P SL W+ S F G+AQ+ HL+++ G F + + Y +I T +
Sbjct: 343 LMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIM 402
Query: 316 LAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSD 375
L +++FY++ +Y ++V+P + G S L+FLK S+WSK + + E+ E +N S
Sbjct: 403 LTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFS 462
Query: 376 DSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKST 435
+ EPVS EF GKEAIRI + K Y K VEAL+ + FDIYEGQITA+LGH+G GKST
Sbjct: 463 EIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKST 522
Query: 436 LLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAK 495
L+NIL GL ++G A+IY ++SEI +M E RK IG CPQ + FD LTV ENL + A
Sbjct: 523 LMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILAS 582
Query: 496 IKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPT 555
IKGI + QEV++++++LDMQ+I+D AKKLSGGQKRKL+LGIA+LG+P++LLLDEPT
Sbjct: 583 IKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPT 642
Query: 556 AGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKR 615
AG+DP SRH VW+LLK K +R+ +FST FMDEADILADRK +S G LKC GSS+FLK
Sbjct: 643 AGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKS 702
Query: 616 KWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSD 675
KWGIGY LS++ ++ C TE ++SL+KQHIP A L +++++LVYSLP + +KF L+S
Sbjct: 703 KWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSA 762
Query: 676 LDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQV 735
LD S+ G+ +Y VS+T+L +VFL LE ++ ID+ D+ + Q+ + ++ EMEQ
Sbjct: 763 LDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQS 822
Query: 736 LCSLPETRKA-VSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVLGIAF-IPIILEKI 793
L L ET+ A VS+ +LW++Q+Y +A F L+RE +++ +LL+L I F + I + +
Sbjct: 823 LLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLV 882
Query: 794 MYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEID 853
+ + P +YFL P TSLL+ N+ S+I DL+ Q+I++ +
Sbjct: 883 HHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM- 941
Query: 854 DFRNRNGSDDPS---YNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNF 910
N SD S ++ A+ V +KDY F+ N+ + P+L+ I+SN + N
Sbjct: 942 ----INDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNV 997
Query: 911 TELIQMESTSFSRD--DIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWI 968
TE IQ+ ST F ++ DIV + + L +I + P+ M + ++K +QL +
Sbjct: 998 TETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKL 1057
Query: 969 SGLWPSAYWCGQALVDIPLYFLI-------LFSIHLIYYFIFLGFQLSWELMFVLVVCII 1021
SGL PSAYW GQA+VDIPL+F+I L + H YF + F +V C+I
Sbjct: 1058 SGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKF-------LAVVFCLI 1110
Query: 1022 GCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFI-ILICVSTIMVS-----TQYEKLNLIL 1075
G S+I TY+ SF F+K FWSF + + L C++ ++ T L+
Sbjct: 1111 GYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHYAF 1170
Query: 1076 CMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRC 1135
C+I IP + LLG ++ I++ + +N+ + N ++ + + + PYLQ V+++F+++
Sbjct: 1171 CII-IPIYPLLGCLISFIKISW-KNVRKNVDTYNPWDR-LSVAVISPYLQCVLWIFLLQY 1227
Query: 1136 LEMKYGNEIMNKDPVFR-ISPRSRETH-PNPEEPEEEDEDVQAERVQAANALTAPNLEEE 1193
E KYG + KDP FR +S +S+ P P + E+EDEDV+AER++ + EE+
Sbjct: 1228 YEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEK 1287
Query: 1194 PVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMIT 1253
P I S LHKEY + K S + KK+A + +SFCVKKGE+LGLLG NGAGKST I ++
Sbjct: 1288 PSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILV 1347
Query: 1254 GCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGK 1313
G +PT+G V L G +S + D+SLK +GYCPQ N LWP T++EH E+Y AVKG+
Sbjct: 1348 GDIEPTSGQVFL-GDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSA 1406
Query: 1314 EDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPE 1373
D ISR+ AL L+E L+ VK L GIKRKLCF LS+LGNP + LLDEP TGMDP+
Sbjct: 1407 SDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPK 1466
Query: 1374 GQQQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGR 1433
+Q MW+ ++ KN++R +LTTHYM EAEAVCDR+A+MVSG LRCIG++QHLK+KFG+
Sbjct: 1467 AKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGK 1526
Query: 1434 DYLLEIKMK---EPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKL 1490
Y LEIK+K E +V+ L EI +FP A+ QE +SS++AYK+P EDV LS++FFKL
Sbjct: 1527 GYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKL 1586
Query: 1491 EAMKQTFNLEEYSLSQATLEQVFLELCKEQ-ELGNVDDKIDTTVEWKLLPQED 1542
E K F +EEYS SQATLEQVF+EL KEQ E N +++T+ W+ QED
Sbjct: 1587 EEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWE-RTQED 1638
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 1189 bits (3075), Expect = 0.0
Identities = 669/1553 (43%), Positives = 966/1553 (62%), Gaps = 52/1553 (3%)
Query: 18 TPDEETMDIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPVIKEHSEYTEHCWAMHGEIF 77
T ++E + L K + VGV+F D+ SY L+F + IPV + + C
Sbjct: 110 TNEKEMLTSSLSKPSN-FVGVVFKDSMSYELRF-FPDMIPVSSIYMDSRAGCSKS----- 162
Query: 78 CYLAKYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFH 137
C A+YW GF QA+I+AAII++ TN S+ +EL S + M +
Sbjct: 163 CEAAQYWSSGFTVLQASIDAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVIL 222
Query: 138 FTCLVSFSSFIYFASLNVARERGK-FKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMA 196
+++FS F YF ++++ E+ K K+ + +MGL ++AFWLSW L Y IF+MS+ MA
Sbjct: 223 IYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLYTSLIFLMSLLMA 282
Query: 197 LVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLG 256
++ T+ + + +VIF L+ LYGLS + A +++ L +K G+ F TV +G +G
Sbjct: 283 VIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIG 342
Query: 257 FTV-LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFFI 315
+ L P SL W+ S F G+AQ+ HL+++ G F + + Y +I T +
Sbjct: 343 LMIILIESFPKSLVWLFSPFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIM 402
Query: 316 LAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSD 375
L +++FY++ +Y ++V+P + G S L+FLK S+WSK + + E+ E +N S
Sbjct: 403 LTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFS 462
Query: 376 DSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKST 435
+ EPVS EF GKEAIRI + K Y K VEAL+ + FDIYEGQITA+LGH+G GKST
Sbjct: 463 EIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKST 522
Query: 436 LLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAK 495
L+NIL GL ++G A+IY ++SEI +M E RK IG CPQ + FD LTV ENL + A
Sbjct: 523 LMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILAS 582
Query: 496 IKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPT 555
IKGI + QEV++++++LDMQ+I+D AKKLSGGQKRKL+LGIA+LG+P++LLLDEPT
Sbjct: 583 IKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPT 642
Query: 556 AGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKR 615
AG+DP SRH VW+LLK K +R+ +FST FMDEADILADRK +S G LKC GSS+FLK
Sbjct: 643 AGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKS 702
Query: 616 KWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSD 675
KWGIGY LS++ ++ C TE ++SL+KQHIP A L +++++LVYSLP + +KF L+S
Sbjct: 703 KWGIGYRLSMYIDKYCATESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSA 762
Query: 676 LDKCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQV 735
LD S+ G+ +Y VS+T+L +VFL LE ++ ID+ D+ + Q+ + ++ EMEQ
Sbjct: 763 LDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPLEEEMDSKSFDEMEQS 822
Query: 736 LCSLPETRKA-VSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVLGIAF-IPIILEKI 793
L L ET+ A VS+ +LW++Q+Y +A F L+RE +++ +LL+L I F + I + +
Sbjct: 823 LLILSETKAALVSTMSLWKQQMYTIAKFHFFTLKRESKSVRSVLLLLLIFFTVQIFMFLV 882
Query: 794 MYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLIVNNTGSNIEDLVHSLKCQDIVLEID 853
+ + P +YFL P TSLL+ N+ S+I DL+ Q+I++ +
Sbjct: 883 HHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSADSDISDLISFFTSQNIMVTM- 941
Query: 854 DFRNRNGSDDPS---YNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNF 910
N SD S ++ A+ V +KDY F+ N+ + P+L+ I+SN + N
Sbjct: 942 ----INDSDYVSVAPHSAALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNV 997
Query: 911 TELIQMESTSFSRD--DIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWI 968
TE IQ+ ST F ++ DIV + + L +I + P+ M + ++K +QL +
Sbjct: 998 TETIQIWSTPFFQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKL 1057
Query: 969 SGLWPSAYWCGQALVDIPLYFLI-------LFSIHLIYYFIFLGFQLSWELMFVLVVCII 1021
SGL PSAYW GQA+VDIPL+F+I L + H YF + F +V C+I
Sbjct: 1058 SGLLPSAYWIGQAVVDIPLFFIILILMLGSLLAFHYGLYFYTVKF-------LAVVFCLI 1110
Query: 1022 GCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFI-ILICVSTIMVS-----TQYEKLNLIL 1075
G S+I TY+ SF F+K FWSF + + L C++ ++ T L+
Sbjct: 1111 GYVPSVILFTYIASFTFKKILNTKEFWSFIYSVAALACIAITEITFFMGYTIATILHYAF 1170
Query: 1076 CMIFIPSFTLLGYVMLLIQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRC 1135
C+I IP + LLG ++ I++ + +N+ + N ++ + + + PYLQ V+++F+++
Sbjct: 1171 CII-IPIYPLLGCLISFIKISW-KNVRKNVDTYNPWDR-LSVAVISPYLQCVLWIFLLQY 1227
Query: 1136 LEMKYGNEIMNKDPVFR-ISPRSRETH-PNPEEPEEEDEDVQAERVQAANALTAPNLEEE 1193
E KYG + KDP FR +S +S+ P P + E+EDEDV+AER++ + EE+
Sbjct: 1228 YEKKYGGRSIRKDPFFRNLSTKSKNRKLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEK 1287
Query: 1194 PVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMIT 1253
P I S LHKEY + K S + KK+A + +SFCVKKGE+LGLLG NGAGKST I ++
Sbjct: 1288 PSIMVSNLHKEYDDKKDFLLSRKVKKVATKYISFCVKKGEILGLLGPNGAGKSTIINILV 1347
Query: 1254 GCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGK 1313
G +PT+G V L G +S + D+SLK +GYCPQ N LWP T++EH E+Y AVKG+
Sbjct: 1348 GDIEPTSGQVFL-GDYSSETSEDDDSLKCMGYCPQINPLWPDTTLQEHFEIYGAVKGMSA 1406
Query: 1314 EDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPE 1373
D ISR+ AL L+E L+ VK L GIKRKLCF LS+LGNP + LLDEP TGMDP+
Sbjct: 1407 SDMKEVISRITHALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPK 1466
Query: 1374 GQQQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGR 1433
+Q MW+ ++ KN++R +LTTHYM EAEAVCDR+A+MVSG LRCIG++QHLK+KFG+
Sbjct: 1467 AKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGK 1526
Query: 1434 DYLLEIKMK---EPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKL 1490
Y LEIK+K E +V+ L EI +FP A+ QE +SS++AYK+P EDV LS++FFKL
Sbjct: 1527 GYFLEIKLKDWIENLEVDRLQREIQYIFPNASRQESFSSILAYKIPKEDVQSLSQSFFKL 1586
Query: 1491 EAMKQTFNLEEYSLSQATLEQVFLELCKEQ-ELGNVDDKIDTTVEWKLLPQED 1542
E K F +EEYS SQATLEQVF+EL KEQ E N +++T+ W+ QED
Sbjct: 1587 EEAKHAFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLNSTLWWE-RTQED 1638
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 325 bits (834), Expect = 2e-88
Identities = 207/640 (32%), Positives = 344/640 (53%), Gaps = 27/640 (4%)
Query: 83 YWLKGFVAFQAAINAAIIEV---TTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFT 139
Y +GF+A Q A++ AI+E + + LT I PPFI+ ++ +
Sbjct: 206 YIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIK-RFPYPPFIADPFLVAIQYQLP 264
Query: 140 CLVSFSSFIYFASLNVAR-----ERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIF 194
L+ S F Y A L +AR + + K+ M +MGL W +W L + F+ I + F
Sbjct: 265 LLLLLS-FTYTA-LTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASF 322
Query: 195 MALVIT-----SIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKP-MLAGLAGFLF 248
M L+ ++ ++ + ++ + +S I+ +F++S K M A GFL+
Sbjct: 323 MTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLY 382
Query: 249 TVFWGCLGFTV-LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGV-----IFPDP 302
+ F Y + LS LLS A G I + G+ + P
Sbjct: 383 FFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVN 442
Query: 303 SGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHE 362
D + +L D++ Y + T Y E V P + G FF+ S+W
Sbjct: 443 VDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAG 502
Query: 363 IFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQI 422
E + +PE + + + PE I+I+++ K + A++ + ++YEGQI
Sbjct: 503 KEEEDSDPEKALRNEYFEAEPE-DLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQI 561
Query: 423 TAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFD 482
T +LGHNGAGK+T L++L+GL T G A I ++S+ DM +IRK++G CPQ + FD
Sbjct: 562 TVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQ--DMVQIRKSLGLCPQHDILFD 619
Query: 483 FLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAI 542
LTV E+L +A++KG+ ++ +EVK+++ + ++ + ++ LSGG +RKL++GIA+
Sbjct: 620 NLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIAL 679
Query: 543 LGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNG 602
+ +VL+LDEPT+G+D SR +W LL+ K DR I+ +T FMDEAD+L DR ++ G
Sbjct: 680 IAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKG 739
Query: 603 KLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLP 662
+L+C GSSLFLK+K+G GYH++L + C+ E I+ L+ H+P+A L + + +L + LP
Sbjct: 740 ELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILP 799
Query: 663 LEKTNKFPDLYSDLDKCSDQ-GIRNYAVSVTSLNEVFLNL 701
E T++F L++ L+K + GI ++ S+T++ EVFL +
Sbjct: 800 RESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRV 839
Score = 204 bits (520), Expect = 4e-52
Identities = 128/359 (35%), Positives = 198/359 (55%), Gaps = 27/359 (7%)
Query: 1170 EDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCV 1229
ED+DV ER + A + +L P+I L K Y + R +A+ +S V
Sbjct: 1357 EDQDVADERTRIL-APSPDSLLHTPLIIKE-LSKVYEQ--------RVPLLAVDRLSLAV 1406
Query: 1230 KKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRAS-----VRQQHDNSLKFLG 1284
+KGE GLLG NGAGK+T+ KM+TG T+G + G R S VRQ+ +G
Sbjct: 1407 QKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQR-------IG 1459
Query: 1285 YCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGI 1344
YCPQ ++L +T +E L +YA ++G+ + + + L L+ V+T S G
Sbjct: 1460 YCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGN 1519
Query: 1345 KRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAE 1404
KRKL ++++G P+V+ LDEP TGMDP ++ +W + A + + ++T+H M E E
Sbjct: 1520 KRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTV-ARARESGKAIIITSHSMEECE 1578
Query: 1405 AVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALH---TEILKLFPQA 1461
A+C R+A+MV G +C+GS QHLK+KFG Y L K++ Q EAL + FP +
Sbjct: 1579 ALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGS 1638
Query: 1462 AWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKEQ 1520
++ + ++ Y LP D+ ++ F LE K+ + +++YS+SQ +LEQVFL Q
Sbjct: 1639 VLEDEHQGMVHYHLPGRDL-SWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQ 1696
Score = 186 bits (471), Expect = 2e-46
Identities = 153/595 (25%), Positives = 278/595 (46%), Gaps = 31/595 (5%)
Query: 937 IFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIH 996
+ LLL + I + + + ++ ++ + + GL +W L+ L+ LI S
Sbjct: 265 LLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFF-LFLLIAASFM 323
Query: 997 LIYYFIFLGFQLSW------ELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSF 1050
+ + + + ++ L+ ++C A+S I ++++S F K F F
Sbjct: 324 TLLFCVKVKPNVAVLSRSDPSLVLAFLLCF---AISTISFSFMVSTFFSKANMAAAFGGF 380
Query: 1051 GFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLLGYVMLLIQLDFM------RNLDSL 1104
+F I + + L+ LC + + + L+ + + R+L S
Sbjct: 381 LYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSP 440
Query: 1105 DNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDP-VFRISPRSRETHPN 1163
N ++ +L L+ L SV++ V +E + + P F I P P
Sbjct: 441 VNVDDDFCFGQVLGMLL--LDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPR 498
Query: 1164 PEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIR 1223
+EE ED E+ AL E EP + + ++ K K + A+R
Sbjct: 499 AVAGKEE-EDSDPEK-----ALRNEYFEAEPEDLVAGIKIKHLS--KVFRVGNKDRAAVR 550
Query: 1224 NVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFL 1283
+++ + +G++ LLGHNGAGK+T++ M+TG PT+G + G S Q K L
Sbjct: 551 DLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEIS--QDMVQIRKSL 608
Query: 1284 GYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEG 1343
G CPQ + L+ LT+ EHL YA +KGL ++ + +++ + L+++ + + LS G
Sbjct: 609 GLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGG 668
Query: 1344 IKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEA 1403
++RKL ++++ V++LDEP +GMD ++ +W +LQ + +R +LTTH+M EA
Sbjct: 669 MRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQR--QKSDRTIVLTTHFMDEA 726
Query: 1404 EAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFPQAAW 1463
+ + DR+A+M G L+C GS LK K+G Y + + + E + + P A
Sbjct: 727 DLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATL 786
Query: 1464 QERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCK 1518
+ + +++ LP E H F KLE ++ + + S T+E+VFL + K
Sbjct: 787 ESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGK 841
Score = 162 bits (410), Expect = 2e-39
Identities = 146/585 (24%), Positives = 267/585 (45%), Gaps = 42/585 (7%)
Query: 150 FASLNVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITSIPIVFHT- 208
F+ L V+ + K + V G+ ++FWLS L + I S+ + +V + + T
Sbjct: 1115 FSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTR 1174
Query: 209 -GFMV-IFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGF--------- 257
G M L LYG ++I L +LM+ A +F + G F
Sbjct: 1175 DGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIP 1234
Query: 258 TVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFFILA 317
V +L +L V +L GMA + +NY + S + + +
Sbjct: 1235 AVKLEELSKTLDHVFLVLPNHCL--GMAVSSFYENYETRRYCT--SSEVAAHYCKKYNIQ 1290
Query: 318 FDTLFYLIFTLYFERVLPDKDGHGDSPL---FFLKSSFWSK---------HQNTHHEIFE 365
+ FY R + G + L F ++++ + + T E++
Sbjct: 1291 YQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYT 1350
Query: 366 NEINPEHSSDDSFEPV-----SPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEG 420
D + E SP+ + I+ + K Y + + A+ + + +G
Sbjct: 1351 RMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLL-AVDRLSLAVQKG 1409
Query: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
+ +LG NGAGK+T +L+G T G A + ++S +D+ ++R+ IG+CPQF+
Sbjct: 1410 ECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRIS--SDVGKVRQRIGYCPQFDAL 1467
Query: 481 FDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGI 540
D +T RE L ++A+++GI + + V+ + L ++ + + + SGG KRKL+ GI
Sbjct: 1468 LDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGI 1527
Query: 541 AILGDPQVLLLDEPTAGLDPFSRHRVW-SLLKEHKVDRLILFSTQFMDEADILADRKVFL 599
A++G+P V+ LDEP+ G+DP +R +W ++ + + + I+ ++ M+E + L R +
Sbjct: 1528 ALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIM 1587
Query: 600 SNGKLKCAGSSLFLKRKWGIGYHLSL---HRNEMCDTEKITSLIKQHIPDAKLTTESEEK 656
G+ KC GS LK K+G GY L + E+ + + P + L E +
Sbjct: 1588 VQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGM 1647
Query: 657 LVYSLPLEKTNKFPDLYSDLDKCSDQ-GIRNYAVSVTSLNEVFLN 700
+ Y LP + + ++ L+K ++ G+ +Y+VS SL +VFL+
Sbjct: 1648 VHYHLP-GRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLS 1691
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 302 bits (773), Expect = 2e-81
Identities = 213/696 (30%), Positives = 341/696 (48%), Gaps = 83/696 (11%)
Query: 82 KYWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKG--EIMNEWFH-F 138
+Y GF Q + AII V T E+ T V M P ++ +M+ F
Sbjct: 587 RYVWGGFAYLQDVVEQAIIRVLTG---TEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLF 643
Query: 139 TCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALV 198
L S V + + K+ M +MGL S W SW ++ + + + + + ++
Sbjct: 644 MTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVI 703
Query: 199 ITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGFT 258
+ ++ ++ V+F S++ + I FL+S L + LA G G + FT
Sbjct: 704 LKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACG-------GIIYFT 756
Query: 259 VLYRQLPLSLGW----------VLSLLSPFAFTAGMAQITHLDNYLSGV----IFPDP-S 303
LY L + W SLLSP AF G + GV +F P
Sbjct: 757 -LYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVE 815
Query: 304 GDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEI 363
D + + + ++ FDT Y + T Y E V P + G F S+W ++ E
Sbjct: 816 EDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESD--EK 873
Query: 364 FENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQIT 423
N + S+ E H K + I+N++K Y + G A+ G+ + YEGQIT
Sbjct: 874 SHPGSNQKRISEICME--EEPTHLKLGVSIQNLVKVY--RDGMKVAVDGLALNFYEGQIT 929
Query: 424 AILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDF 483
+ LGHNGAGK+T ++IL+GL T G+A I + ++M IR+N+G CPQ N FD
Sbjct: 930 SFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIR--SEMSTIRQNLGVCPQHNVLFDM 987
Query: 484 LTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQ-DIIAKKLSGGQKRKLTLGIAI 542
LTV E++ +A++KG+ K V+ E++++ +++ + S + +LSGG +RKL++ +A
Sbjct: 988 LTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAF 1047
Query: 543 LGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNG 602
+G +V++LDEPTAG+DP+SR +W LL +++ R I+ ST MDEAD+L DR +S+G
Sbjct: 1048 VGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHG 1107
Query: 603 KLKCAGSSLFLKRKWGIGYHLSLHRNEM-------------------------------- 630
KL C GSSLFLK + G GY+L+L + ++
Sbjct: 1108 KLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGL 1167
Query: 631 ----------CDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLE--KTNKFPDLYSDL-D 677
D I++LI++H+ +A+L + +L Y LP E K F +L+ ++ D
Sbjct: 1168 GSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDD 1227
Query: 678 KCSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFD 713
+ SD GI +Y +S T+L E+FL + +S +D D
Sbjct: 1228 RLSDLGISSYGISETTLEEIFLKVAEESGVDAETSD 1263
Score = 211 bits (536), Expect = 6e-54
Identities = 172/611 (28%), Positives = 296/611 (48%), Gaps = 63/611 (10%)
Query: 926 IVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDI 985
++ + F+ S + LI VS K++Q +ISG+ P YW + D+
Sbjct: 1661 VIFAMSFVPASFVVFLIQERVSK----------AKHLQ---FISGVKPVIYWLSNFVWDM 1707
Query: 986 PLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFR-KWRKN 1044
Y + + +I+ +S + VL + ++ S+ L Y SF+F+
Sbjct: 1708 CNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAY 1767
Query: 1045 NGFWSFGFFI-----ILICVSTIMVSTQYEKLNLILCMIFI--PSFTLLGYVMLLIQLDF 1097
S FI + V + + +N IL +F+ P F L ++ +++
Sbjct: 1768 VVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQA 1827
Query: 1098 MRNLDSLD----NR-INEVNKTILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDPVFR 1152
M D+L+ NR ++ ++ ++ L + F+I L +R
Sbjct: 1828 MA--DALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQ------------YR 1873
Query: 1153 ISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSC 1212
R R + +EDEDV+ ER + + ++ E +T K Y
Sbjct: 1874 FFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELT-----KIY------- 1921
Query: 1213 FSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSR--A 1270
RK+K A+ + + GE GLLG NGAGKS++ KM+TG T T G L + +
Sbjct: 1922 --RRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILS 1979
Query: 1271 SVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQ 1330
++ + H N +GYCPQ +++ LT +EH+E +A ++G+ +++ + L L
Sbjct: 1980 NIHEVHQN----MGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLV 2035
Query: 1331 EQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKE 1390
+ + S G KRKL ++++G P VV LDEP TGMDP+ ++ +W + VK +
Sbjct: 2036 KYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVK-EG 2094
Query: 1391 RGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMK-EPTQVEA 1449
R +LT+H M E EA+C RMA+MV+G RC+GS+QHLKN+FG Y + +++ ++
Sbjct: 2095 RSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKP 2154
Query: 1450 LHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATL 1509
+ FP + +E++ +++ Y+LP + L+R F L K+ ++E+YS+SQ TL
Sbjct: 2155 VQDFFGLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTL 2213
Query: 1510 EQVFLELCKEQ 1520
+QVF+ K+Q
Sbjct: 2214 DQVFVNFAKDQ 2224
Score = 159 bits (402), Expect = 2e-38
Identities = 105/351 (29%), Positives = 181/351 (51%), Gaps = 12/351 (3%)
Query: 389 EAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTE 448
+ + I+ + K Y K + A+ I I G+ +LG NGAGKS+ +L+G + T
Sbjct: 1910 DILEIKELTKIYRRK--RKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTR 1967
Query: 449 GSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEV 508
G A + + ++++ E+ +N+G+CPQF+ + LT RE++ FA ++G+ KEV +
Sbjct: 1968 GDAFLNKNSI--LSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVG 2025
Query: 509 KRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWS 568
+ I +L + + A SGG KRKL+ +A++G P V+ LDEPT G+DP +R +W+
Sbjct: 2026 EWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWN 2085
Query: 569 -LLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLH- 626
L K R ++ ++ M+E + L R + NG+ +C GS LK ++G GY + +
Sbjct: 2086 CALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRI 2145
Query: 627 RNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQ-GIR 685
D + + P + L + L Y LP + ++S L + + I
Sbjct: 2146 AGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLP-SSLSSLARIFSILSQSKKRLHIE 2204
Query: 686 NYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVL 736
+Y+VS T+L++VF+N A D+ D D K +H + D + + L
Sbjct: 2205 DYSVSQTTLDQVFVNF----AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFL 2251
Score = 154 bits (390), Expect = 5e-37
Identities = 99/347 (28%), Positives = 169/347 (48%), Gaps = 51/347 (14%)
Query: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDN 1278
K+A+ ++ +G++ LGHNGAGK+T++ ++TG PT+G + G +R +
Sbjct: 913 KVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGK--DIRSEMST 970
Query: 1279 SLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKL-QEQLKAPV 1337
+ LG CPQ N L+ LT++EH+ YA +KGL ++ + ++ + L +LK+
Sbjct: 971 IRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKT 1030
Query: 1338 KTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKE-RGTLLT 1396
LS G++RKL L+ +G VV+LDEP G+DP ++ +W++L +K ++ R +L+
Sbjct: 1031 SQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELL---LKYRQGRTIILS 1087
Query: 1397 THYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKE------------- 1443
TH+M EA+ + DR+A++ G L C+GS LKN+ G Y L + K+
Sbjct: 1088 THHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSS 1147
Query: 1444 -----------------------------PTQVEALHTEILKLFPQAAWQERYSSLMAYK 1474
V A+ I K +A E + Y
Sbjct: 1148 TVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYV 1207
Query: 1475 LPVEDVH--PLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKE 1519
LP E F +++ + Y +S+ TLE++FL++ +E
Sbjct: 1208 LPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEE 1254
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 294 bits (752), Expect = 5e-79
Identities = 225/769 (29%), Positives = 373/769 (48%), Gaps = 75/769 (9%)
Query: 17 GTPDEETM-DIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPV-IKEHSEYTEHCWAMHG 74
G PDEE++ + L + Y + V V S F R + + I+++S +TE +
Sbjct: 582 GFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRR 641
Query: 75 EIFCYLAK-----YWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKG 129
+ Y+L GFV Q + AII+ H V+E + V M P ++
Sbjct: 642 AYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVEPGSYV---QMFPYPCYTRD 698
Query: 130 EIMNEWFHFTCLVSFSSFIYFASLN----VARERGKFKKLMTVMGLRESAFWLSWGLTYI 185
+ + H L S++Y ++ VA + + K++M MGL + W++W +T
Sbjct: 699 DFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGF 758
Query: 186 CFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAG 245
+ I + ++ ++ H+ ++I+ ++Y ++ I FL+SVL K LA G
Sbjct: 759 VQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACG 818
Query: 246 ----FLFTV--FWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIF 299
FL V + + V + ++ + SL+S AF G + G+ +
Sbjct: 819 GIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQW 878
Query: 300 PDPS-----GDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWS 354
S GD + ++ +L D + Y I T Y E V P G F L+ S+W
Sbjct: 879 HTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWL 938
Query: 355 KHQNTHHEIFENEI----NPEHSSDDSFEPVSPEFHGKEAIR--------------IRNV 396
T E +E P S + + + E E R + +
Sbjct: 939 GSGRT--EAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKL 996
Query: 397 IKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNT 456
K Y K K AL + ++YE Q+ + LGHNGAGK+T ++IL+GL T GSATIY
Sbjct: 997 TKVY--KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGH 1054
Query: 457 QLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELD 516
+ T+M+EIRKN+G CPQ N FD LTV E+L ++++K + +E+ +E+ ++I +L+
Sbjct: 1055 DIR--TEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLE 1112
Query: 517 MQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVD 576
+ + + + + LSGG KRKL++ IA +G + ++LDEPTAG+DP++R +W L+ ++K
Sbjct: 1113 LSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPG 1172
Query: 577 RLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRN-------- 628
R IL ST MDEAD+L DR +S+GKLKC GS LFLK +G GY L+L +
Sbjct: 1173 RTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQ 1232
Query: 629 --------------EMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNK--FPDL 672
C +++ I++H+ L +++ +L Y LP E K F L
Sbjct: 1233 EPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERL 1292
Query: 673 YSDLDKCSDQ-GIRNYAVSVTSLNEVFLNL-EGKSAIDEPDFDIGKQEK 719
+ L++ D + ++ + T+L EVFL + E +++ + D+ + K
Sbjct: 1293 FQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRK 1341
Score = 226 bits (575), Expect = 2e-58
Identities = 129/365 (35%), Positives = 209/365 (57%), Gaps = 15/365 (4%)
Query: 1156 RSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFST 1215
R + P +P E+D DV +ER + + ++ L K Y K
Sbjct: 2016 RRPQRMPVSTKPVEDDVDVASERQRVLRGDA-----DNDMVKIENLTKVYKSRKIG---- 2066
Query: 1216 RKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQ 1275
+ +A+ + V+ GE GLLG NGAGK+++ KM+TG T G + G SV ++
Sbjct: 2067 --RILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGH--SVLKE 2122
Query: 1276 HDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKA 1335
+ LGYCPQ ++L+ +LT +EHL+LY ++G+ +D A + +E L+L +
Sbjct: 2123 LLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADK 2182
Query: 1336 PVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLL 1395
P T S G KRKL ++++G P+ + LDEP TGMDP+ ++ +W ++ +K R +L
Sbjct: 2183 PAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKT-GRSVVL 2241
Query: 1396 TTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEIL 1455
T+H M E EA+C R+A+MV+G LRC+GSIQHLKN+FG Y++ ++ K V+ +
Sbjct: 2242 TSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFN 2301
Query: 1456 KLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLE 1515
+ FP+A +ER+ + + Y+L E + L++ F K+E + +E+YS+SQ TL+ VF+
Sbjct: 2302 RNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVN 2360
Query: 1516 LCKEQ 1520
K+Q
Sbjct: 2361 FAKKQ 2365
Score = 177 bits (449), Expect = 7e-44
Identities = 99/321 (30%), Positives = 182/321 (56%), Gaps = 6/321 (1%)
Query: 389 EAIRIRNVIKEYNG-KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVST 447
+ ++I N+ K Y K G++ A+ + + G+ +LG NGAGK++ +L+G +T
Sbjct: 2049 DMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTT 2108
Query: 448 EGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE 507
G A + S + ++ ++++++G+CPQ + FD LT RE+L+++ +++GI K+ +
Sbjct: 2109 GGEAFVNGH--SVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARV 2166
Query: 508 VKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVW 567
VK + +L++ D A SGG KRKL+ IA++G P + LDEPT G+DP +R +W
Sbjct: 2167 VKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLW 2226
Query: 568 SLLKE-HKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLH 626
+L+ + K R ++ ++ M+E + L R + NG+L+C GS LK ++G GY +++
Sbjct: 2227 NLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVR 2286
Query: 627 RNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSD-QGIR 685
+ + ++ P+A L K+ Y L E + ++S +++ S GI
Sbjct: 2287 TKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKMEQVSGVLGIE 2345
Query: 686 NYAVSVTSLNEVFLNLEGKSA 706
+Y+VS T+L+ VF+N K +
Sbjct: 2346 DYSVSQTTLDNVFVNFAKKQS 2366
Score = 170 bits (430), Expect = 1e-41
Identities = 117/381 (30%), Positives = 194/381 (50%), Gaps = 46/381 (12%)
Query: 1172 EDVQAERVQAANALTAPNLEEEP-----VITASCLHKEYYETKKSCFSTRKKKIAIRNVS 1226
E+ QA +++ +EEEP V+ L K Y + KK +A+ +S
Sbjct: 962 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKK---------LALNKLS 1012
Query: 1227 FCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYC 1286
+ + +V+ LGHNGAGK+T++ ++TG PT+G + G +R + D K LG C
Sbjct: 1013 LNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGH--DIRTEMDEIRKNLGMC 1070
Query: 1287 PQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKR 1346
PQ N L+ +LT++EHL Y+ +K + +E+ + +++E L+L + + V+TLS G+KR
Sbjct: 1071 PQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKR 1130
Query: 1347 KLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKE-RGTLLTTHYMSEAEA 1405
KL ++ +G ++LDEP G+DP ++ +W ++ +K K R LL+TH+M EA+
Sbjct: 1131 KLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI---LKYKPGRTILLSTHHMDEADL 1187
Query: 1406 VCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPT-----QVEALHTEILKLFPQ 1460
+ DR+A++ G L+C GS LK +G Y L + +K P Q L + P
Sbjct: 1188 LGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTL-VKRPAEPGGPQEPGLASSPPGRAPL 1246
Query: 1461 AAWQERY------------------SSLMAYKLPVEDVH--PLSRAFFKLEAMKQTFNLE 1500
++ E S+ ++Y LP E R F LE +L
Sbjct: 1247 SSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLS 1306
Query: 1501 EYSLSQATLEQVFLELCKEQE 1521
+ L TLE+VFL++ +E +
Sbjct: 1307 SFGLMDTTLEEVFLKVSEEDQ 1327
Score = 34.3 bits (77), Expect = 0.96
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 16/117 (13%)
Query: 145 SSFIYFASLNVARERGKFKKLMTVMGLRESAFWLS---WG-LTYI----CFIFIMSIFMA 196
+SF+ F VA + K K L V G +WL+ W L Y+ C + I+ +F
Sbjct: 1808 ASFVVFL---VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDL 1864
Query: 197 LVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWG 253
TS T F + +L+ LYG S+ + + S P A + + +F G
Sbjct: 1865 PAYTS-----PTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIG 1916
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 294 bits (752), Expect = 5e-79
Identities = 225/769 (29%), Positives = 373/769 (48%), Gaps = 75/769 (9%)
Query: 17 GTPDEETM-DIELPKKYHEMVGVIFSDTFSYRLKFNWGYRIPV-IKEHSEYTEHCWAMHG 74
G PDEE++ + L + Y + V V S F R + + I+++S +TE +
Sbjct: 612 GFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSFTEKTNEIRR 671
Query: 75 EIFCYLAK-----YWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKG 129
+ Y+L GFV Q + AII+ H V+E + V M P ++
Sbjct: 672 AYWRPGPNTGGRFYFLYGFVWIQDMMERAIIDTFVGHDVVEPGSYV---QMFPYPCYTRD 728
Query: 130 EIMNEWFHFTCLVSFSSFIYFASLN----VARERGKFKKLMTVMGLRESAFWLSWGLTYI 185
+ + H L S++Y ++ VA + + K++M MGL + W++W +T
Sbjct: 729 DFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGF 788
Query: 186 CFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAG 245
+ I + ++ ++ H+ ++I+ ++Y ++ I FL+SVL K LA G
Sbjct: 789 VQLSISVTALTAILKYGQVLMHSHVVIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACG 848
Query: 246 ----FLFTV--FWGCLGFTVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIF 299
FL V + + V + ++ + SL+S AF G + G+ +
Sbjct: 849 GIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQW 908
Query: 300 PDPS-----GDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWS 354
S GD + ++ +L D + Y I T Y E V P G F L+ S+W
Sbjct: 909 HTFSQSPVEGDDFNLLLAVTMLMVDAVVYGILTWYIEAVHPGMYGLPRPWYFPLQKSYWL 968
Query: 355 KHQNTHHEIFENEI----NPEHSSDDSFEPVSPEFHGKEAIR--------------IRNV 396
T E +E P S + + + E E R + +
Sbjct: 969 GSGRT--EAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKL 1026
Query: 397 IKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNT 456
K Y K K AL + ++YE Q+ + LGHNGAGK+T ++IL+GL T GSATIY
Sbjct: 1027 TKVY--KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGH 1084
Query: 457 QLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELD 516
+ T+M+EIRKN+G CPQ N FD LTV E+L ++++K + +E+ +E+ ++I +L+
Sbjct: 1085 DIR--TEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLE 1142
Query: 517 MQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVD 576
+ + + + + LSGG KRKL++ IA +G + ++LDEPTAG+DP++R +W L+ ++K
Sbjct: 1143 LSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPG 1202
Query: 577 RLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRN-------- 628
R IL ST MDEAD+L DR +S+GKLKC GS LFLK +G GY L+L +
Sbjct: 1203 RTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQ 1262
Query: 629 --------------EMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNK--FPDL 672
C +++ I++H+ L +++ +L Y LP E K F L
Sbjct: 1263 EPGLASSPPGRAPLSSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERL 1322
Query: 673 YSDLDKCSDQ-GIRNYAVSVTSLNEVFLNL-EGKSAIDEPDFDIGKQEK 719
+ L++ D + ++ + T+L EVFL + E +++ + D+ + K
Sbjct: 1323 FQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRK 1371
Score = 226 bits (575), Expect = 2e-58
Identities = 129/365 (35%), Positives = 209/365 (57%), Gaps = 15/365 (4%)
Query: 1156 RSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFST 1215
R + P +P E+D DV +ER + + ++ L K Y K
Sbjct: 2046 RRPQRMPVSTKPVEDDVDVASERQRVLRGDA-----DNDMVKIENLTKVYKSRKIG---- 2096
Query: 1216 RKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQ 1275
+ +A+ + V+ GE GLLG NGAGK+++ KM+TG T G + G SV ++
Sbjct: 2097 --RILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGH--SVLKE 2152
Query: 1276 HDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKA 1335
+ LGYCPQ ++L+ +LT +EHL+LY ++G+ +D A + +E L+L +
Sbjct: 2153 LLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALEKLELTKYADK 2212
Query: 1336 PVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLL 1395
P T S G KRKL ++++G P+ + LDEP TGMDP+ ++ +W ++ +K R +L
Sbjct: 2213 PAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKT-GRSVVL 2271
Query: 1396 TTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEIL 1455
T+H M E EA+C R+A+MV+G LRC+GSIQHLKN+FG Y++ ++ K V+ +
Sbjct: 2272 TSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTKSSQSVKDVVRFFN 2331
Query: 1456 KLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLE 1515
+ FP+A +ER+ + + Y+L E + L++ F K+E + +E+YS+SQ TL+ VF+
Sbjct: 2332 RNFPEAMLKERHHTKVQYQLKSEHI-SLAQVFSKMEQVSGVLGIEDYSVSQTTLDNVFVN 2390
Query: 1516 LCKEQ 1520
K+Q
Sbjct: 2391 FAKKQ 2395
Score = 177 bits (449), Expect = 7e-44
Identities = 99/321 (30%), Positives = 182/321 (56%), Gaps = 6/321 (1%)
Query: 389 EAIRIRNVIKEYNG-KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVST 447
+ ++I N+ K Y K G++ A+ + + G+ +LG NGAGK++ +L+G +T
Sbjct: 2079 DMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTT 2138
Query: 448 EGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE 507
G A + S + ++ ++++++G+CPQ + FD LT RE+L+++ +++GI K+ +
Sbjct: 2139 GGEAFVNGH--SVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARV 2196
Query: 508 VKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVW 567
VK + +L++ D A SGG KRKL+ IA++G P + LDEPT G+DP +R +W
Sbjct: 2197 VKWALEKLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLW 2256
Query: 568 SLLKE-HKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLH 626
+L+ + K R ++ ++ M+E + L R + NG+L+C GS LK ++G GY +++
Sbjct: 2257 NLILDLIKTGRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVR 2316
Query: 627 RNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSD-QGIR 685
+ + ++ P+A L K+ Y L E + ++S +++ S GI
Sbjct: 2317 TKSSQSVKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHIS-LAQVFSKMEQVSGVLGIE 2375
Query: 686 NYAVSVTSLNEVFLNLEGKSA 706
+Y+VS T+L+ VF+N K +
Sbjct: 2376 DYSVSQTTLDNVFVNFAKKQS 2396
Score = 170 bits (430), Expect = 1e-41
Identities = 117/381 (30%), Positives = 194/381 (50%), Gaps = 46/381 (12%)
Query: 1172 EDVQAERVQAANALTAPNLEEEP-----VITASCLHKEYYETKKSCFSTRKKKIAIRNVS 1226
E+ QA +++ +EEEP V+ L K Y + KK +A+ +S
Sbjct: 992 EEDQACAMESRRFEETRGMEEEPTHLPLVVCVDKLTKVYKDDKK---------LALNKLS 1042
Query: 1227 FCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLGYC 1286
+ + +V+ LGHNGAGK+T++ ++TG PT+G + G +R + D K LG C
Sbjct: 1043 LNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGH--DIRTEMDEIRKNLGMC 1100
Query: 1287 PQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKR 1346
PQ N L+ +LT++EHL Y+ +K + +E+ + +++E L+L + + V+TLS G+KR
Sbjct: 1101 PQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIEDLELSNKRHSLVQTLSGGMKR 1160
Query: 1347 KLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKE-RGTLLTTHYMSEAEA 1405
KL ++ +G ++LDEP G+DP ++ +W ++ +K K R LL+TH+M EA+
Sbjct: 1161 KLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLI---LKYKPGRTILLSTHHMDEADL 1217
Query: 1406 VCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPT-----QVEALHTEILKLFPQ 1460
+ DR+A++ G L+C GS LK +G Y L + +K P Q L + P
Sbjct: 1218 LGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTL-VKRPAEPGGPQEPGLASSPPGRAPL 1276
Query: 1461 AAWQERY------------------SSLMAYKLPVEDVH--PLSRAFFKLEAMKQTFNLE 1500
++ E S+ ++Y LP E R F LE +L
Sbjct: 1277 SSCSELQVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLS 1336
Query: 1501 EYSLSQATLEQVFLELCKEQE 1521
+ L TLE+VFL++ +E +
Sbjct: 1337 SFGLMDTTLEEVFLKVSEEDQ 1357
Score = 34.3 bits (77), Expect = 0.96
Identities = 32/117 (27%), Positives = 50/117 (42%), Gaps = 16/117 (13%)
Query: 145 SSFIYFASLNVARERGKFKKLMTVMGLRESAFWLS---WG-LTYI----CFIFIMSIFMA 196
+SF+ F VA + K K L V G +WL+ W L Y+ C + I+ +F
Sbjct: 1838 ASFVVFL---VAEKSTKAKHLQFVSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDL 1894
Query: 197 LVITSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWG 253
TS T F + +L+ LYG S+ + + S P A + + +F G
Sbjct: 1895 PAYTS-----PTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIG 1946
>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
sapiens]
Length = 2146
Score = 277 bits (709), Expect = 5e-74
Identities = 214/716 (29%), Positives = 346/716 (48%), Gaps = 92/716 (12%)
Query: 146 SFIYFASLNV---ARERG-KFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITS 201
++IY +L V RE+ + + M MGL + WL W L+ + + + + LV+
Sbjct: 557 AWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKL 616
Query: 202 IPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFL--FTVFWGCLGFTV 259
I+ ++ V+F + + ++ + +FL+S + LA G L F+++ +
Sbjct: 617 GDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVA 676
Query: 260 LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPD----PSGDSYKMIATFFI 315
+LP SLLSP AF G + L+ G + + P+ D + + +
Sbjct: 677 WRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGL 736
Query: 316 LAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSD 375
L D Y + T Y E V P + G + F + S+W + P S
Sbjct: 737 LLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPR------------PPKSPA 784
Query: 376 DSFEPVSPEFHGKEA-------IRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGH 428
P+ P+ +EA + +R++ K + G AL+G+ D Y+G ITA LGH
Sbjct: 785 PCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQP--ALRGLSLDFYQGHITAFLGH 842
Query: 429 NGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRE 488
NGAGK+T L+ILSGL + GSA I + + M IR ++G CPQ+N FD LTV E
Sbjct: 843 NGAGKTTTLSILSGLFPPSGGSAFILGHDVR--SSMAAIRPHLGVCPQYNVLFDMLTVDE 900
Query: 489 NLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQV 548
++ + ++KG+ V E R++ ++ + S Q + + LSGG +RKL++ IA +G QV
Sbjct: 901 HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQV 960
Query: 549 LLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAG 608
++LDEPTAG+DP SR +W LL +++ R ++ ST +DEA++L DR ++ G+L C G
Sbjct: 961 VILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCG 1020
Query: 609 SSLFLKRKWGIGYHLSLHR-------NEMCDTE-----------------------KITS 638
S LFL+R G GY+L+L + NE DT+ ++ +
Sbjct: 1021 SPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLA 1080
Query: 639 LIKQHIPDAKLTTESEEKLVYSLPLEKTN--KFPDLYSDLD-KCSDQGIRNYAVSVTSLN 695
L++ +P A+L E +LV LP + F L+ +LD + ++ + Y +S TSL
Sbjct: 1081 LVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLE 1140
Query: 696 EVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTG-----------DESEME--QVLCSLPET 742
E+FL + + A D D + G + T G E+ +E + S PET
Sbjct: 1141 EIFLKVVEECAAD-TDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPET 1199
Query: 743 RKA--------VSSAALWRRQIYAVATLRFLKLRRERRALLCLL----LVLGIAFI 786
+ V AL R+Q+ A+ RFL RR RR L + L +G+A +
Sbjct: 1200 DQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALV 1255
Score = 198 bits (503), Expect = 4e-50
Identities = 173/619 (27%), Positives = 294/619 (47%), Gaps = 80/619 (12%)
Query: 926 IVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDI 985
+V + F+ S L+LI V+ K++Q + GL P+ YW G L D+
Sbjct: 1542 VVFAMSFVPASFTLVLIEERVTR----------AKHLQL---MGGLSPTLYWLGNFLWDM 1588
Query: 986 PLYFLILFSIHLIYYFIFLGFQ----LSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKW 1041
Y + I IFL FQ ++ + L++ ++ S+ L Y SF F
Sbjct: 1589 CNYLVPA----CIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSV- 1643
Query: 1042 RKNNGFWSFGFFIILICVST--------------IMVSTQYEKLNLILCMIFI--PSFTL 1085
+++L C++ + + ++++ IL +F+ P F L
Sbjct: 1644 -------PSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCL 1696
Query: 1086 LGYVMLLIQLDFMRN-LDSLDNRINEVNKTILLTTLIPYLQSVIF---LFVIRCLEMKYG 1141
++ +++ M + + L +R + + + L +++ LF++ L +++
Sbjct: 1697 GRGLIDMVRNQAMADAFERLGDR--QFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHR 1754
Query: 1142 NEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCL 1201
++++ + PR R EEDEDV ER + T + V+ L
Sbjct: 1755 SQLLPQ-------PRVRSL----PLLGEEDEDVARERERVVQGAT-----QGDVLVLRNL 1798
Query: 1202 HKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAG 1261
K Y ++ A+ + + GE GLLG NGAGK+++ +M+TG T + G
Sbjct: 1799 TKVY---------RGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRG 1849
Query: 1262 VVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSIS 1321
VL G SV ++ + +GYCPQ ++++ LT +EHLEL A ++G+ + A +
Sbjct: 1850 EAVLAGH--SVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAG 1907
Query: 1322 RLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQI 1381
+ L L P T S G KRKL L+++G+P+VV LDEP TGMDP ++ +W
Sbjct: 1908 SGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNS 1967
Query: 1382 LQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKM 1441
L A V+ + R +LT+H M E EA+C R+A+MV+G RC+GS QHLK +F + L +++
Sbjct: 1968 LLAVVR-EGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV 2026
Query: 1442 KEPTQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEE 1501
A + FP A +E + + ++LP L+R F +L +E+
Sbjct: 2027 PAARSQPAA-AFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED 2085
Query: 1502 YSLSQATLEQVFLELCKEQ 1520
+S+SQ LE+VFL K+Q
Sbjct: 2086 FSVSQTMLEEVFLYFSKDQ 2104
Score = 153 bits (386), Expect = 1e-36
Identities = 94/323 (29%), Positives = 169/323 (52%), Gaps = 7/323 (2%)
Query: 389 EAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTE 448
+ + +RN+ K Y G+ ++ A+ + I G+ +LG NGAGK++ +++G ++++
Sbjct: 1791 DVLVLRNLTKVYRGQ--RMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASR 1848
Query: 449 GSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEV 508
G A + ++ + ++G+CPQ + F+ LT RE+L + A+++G+ +V Q
Sbjct: 1849 GEAVLAGHSVAREPSAAHL--SMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTA 1906
Query: 509 KRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVW- 567
+ L + D A SGG KRKL +A++GDP V+ LDEPT G+DP +R +W
Sbjct: 1907 GSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWN 1966
Query: 568 SLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHR 627
SLL + R ++ ++ M+E + L R + NG+ +C GS LK ++ G+ L+L R
Sbjct: 1967 SLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL-R 2025
Query: 628 NEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLD-KCSDQGIRN 686
++ + + P A+L +L + LP ++ +L ++ G+ +
Sbjct: 2026 VPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED 2085
Query: 687 YAVSVTSLNEVFLNLEGKSAIDE 709
++VS T L EVFL DE
Sbjct: 2086 FSVSQTMLEEVFLYFSKDQGKDE 2108
Score = 140 bits (354), Expect = 7e-33
Identities = 108/367 (29%), Positives = 170/367 (46%), Gaps = 51/367 (13%)
Query: 1221 AIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSL 1280
A+R +S +G + LGHNGAGK+T++ +++G P+ G + G VR
Sbjct: 823 ALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGH--DVRSSMAAIR 880
Query: 1281 KFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTL 1340
LG CPQ N L+ LT+ EH+ Y +KGL RL++ + L + + L
Sbjct: 881 PHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHL 940
Query: 1341 SEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTL-LTTHY 1399
S G++RKL ++ +G VV+LDEP G+DP ++ +W++L +K +E TL L+TH+
Sbjct: 941 SGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELL---LKYREGRTLILSTHH 997
Query: 1400 MSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI-------------------- 1439
+ EAE + DR+A++ G L C GS L+ G Y L +
Sbjct: 998 LDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGS 1057
Query: 1440 -----KMKEPTQVEALHT-EILKL----FPQAAWQERYSSLMAYKLPVEDVHPLSRA--F 1487
+ K +Q + T ++L L P A E + LP H S A F
Sbjct: 1058 VDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLF 1117
Query: 1488 FKLEAMKQTFNLEEYSLSQATLEQVFLELCKE-------------QELGNVDDKIDTTVE 1534
+L+ L Y +S +LE++FL++ +E Q L +D T+
Sbjct: 1118 RELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLR 1177
Query: 1535 WKLLPQE 1541
K+ PQE
Sbjct: 1178 LKMPPQE 1184
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 277 bits (709), Expect = 5e-74
Identities = 189/662 (28%), Positives = 328/662 (49%), Gaps = 54/662 (8%)
Query: 86 KGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSFS 145
+ F+ Q +I AIIE+ T + E V I P K + + +V
Sbjct: 701 RAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPY---PCFMKDNFLTSVSYSLPIVLMV 757
Query: 146 SFIYFASLNVAR----ERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITS 201
+++ F + V + + + + M +MG+ + + +W + + F+ + + + +++
Sbjct: 758 AWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKF 817
Query: 202 IPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTV--FWGCLGFTV 259
I+ T ++F +S Y S+IA+++L+SV +A L G L + F+ +
Sbjct: 818 GNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVT 877
Query: 260 LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFF----- 314
+ +L L +SLLSP AF+ I + G+ + + + T F
Sbjct: 878 VENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCC 937
Query: 315 ILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWS--------KHQNTHHEIFEN 366
++ D+ Y + Y V P G F + S+W K + ++ +F N
Sbjct: 938 LILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTN 997
Query: 367 --------EINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIY 418
+PE+ + EP + + + V K Y K A+ + + Y
Sbjct: 998 IMMQNTNPSASPEYMFSSNIEPEPKDL--TVGVALHGVTKIYGSKV----AVDNLNLNFY 1051
Query: 419 EGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFN 478
EG IT++LG NGAGK+T +++L+GL ++ G+ +Y + TD+ +RKN+G C Q +
Sbjct: 1052 EGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGVCMQHD 1109
Query: 479 FQFDFLTVRENLRVFAKIKGIQ--PKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKL 536
F +LT +E+L ++ IK K++ +EVKR + + + S + LSGG KRKL
Sbjct: 1110 VLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKL 1169
Query: 537 TLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRK 596
++ IA++G +V++LDEP+ G+DP SR +W ++ ++K R I+ ST +DEA++L+DR
Sbjct: 1170 SISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRI 1229
Query: 597 VFLSNGKLKCAGSSLFLKRKWGIGYHL--------SLHRNEMCDTEKITSLIKQHIPDAK 648
FL G L+C GS +LK +G GYHL +L+ N +CDT +T++I+ H+P+A
Sbjct: 1230 AFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAY 1289
Query: 649 LTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQGIRN-----YAVSVTSLNEVFLNLEG 703
L + +LVY LP T K Y L + D G+ + Y +S T++ EVFLNL
Sbjct: 1290 LKEDIGGELVYVLPPFST-KVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTK 1348
Query: 704 KS 705
+S
Sbjct: 1349 ES 1350
Score = 237 bits (604), Expect = 7e-62
Identities = 178/598 (29%), Positives = 302/598 (50%), Gaps = 67/598 (11%)
Query: 955 ISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFL-ILFSIHLIYYFIFLGFQLSWELM 1013
+ +++ + ISG+ + YW + D+ Y + + FSI +I F F L
Sbjct: 1691 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLG 1750
Query: 1014 FV-LVVCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICV-------STIMVS 1065
V L++ + G A Y+L+ +F + + FI +CV S + +S
Sbjct: 1751 AVSLLLLLFGYAT--FSWMYLLAGLFHE--------TGMAFITYVCVNLFFGINSIVSLS 1800
Query: 1066 TQY------------EKLNLILCMIFI--PSFTLLGYVMLLIQ-----LDFMRNLD-SLD 1105
Y E ++ L IF+ P F GY ++ + LDF++
Sbjct: 1801 VVYFLSKEKPNDPTLELISETLKRIFLIFPQF-CFGYGLIELSQQQSVLDFLKAYGVEYP 1859
Query: 1106 NRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDPVFRISPRSRE-THPNP 1164
N E+NK L + + F +R L +N+ + ++ R+ +
Sbjct: 1860 NETFEMNK--LGAMFVALVSQGTMFFSLRLL--------INESLIKKLRLFFRKFNSSHV 1909
Query: 1165 EEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIRN 1224
E +EDEDV+AER++ + E ++ CL K Y KK IA+ N
Sbjct: 1910 RETIDEDEDVRAERLRVESGAA-----EFDLVQLYCLTKTYQ-------LIHKKIIAVNN 1957
Query: 1225 VSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLG 1284
+S + GE GLLG NGAGK+T KM+TG P++G ++++ S+ D+ +G
Sbjct: 1958 ISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHV-DSHSSLVG 2016
Query: 1285 YCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGI 1344
YCPQE++L +T++EHL YA V G+ ++D ++ +L+ L L S G
Sbjct: 2017 YCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGT 2076
Query: 1345 KRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAE 1404
KRKL L+++G PS++LLDEP +GMDP+ ++ +W+I+ V+NK +LT+H M E E
Sbjct: 2077 KRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNK-CSVILTSHSMEECE 2135
Query: 1405 AVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKL-FPQAAW 1463
A+C R+A+MV+G +CIGS+QH+K++FGR + +++ +K T+ ++L FP+
Sbjct: 2136 ALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYL 2195
Query: 1464 QERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKEQE 1521
++++ S++ Y +PV ++ F LE K N+ + +SQ TLE+VF+ K+Q+
Sbjct: 2196 KDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQK 2252
Score = 181 bits (458), Expect = 6e-45
Identities = 156/600 (26%), Positives = 280/600 (46%), Gaps = 75/600 (12%)
Query: 142 VSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITS 201
V+ +SF+ + V + K K+L + G+ + +W++ FI+ M ++
Sbjct: 1681 VTTASFVTYV---VREHQTKAKQLQHISGIGVTCYWVT------NFIYDMVFYL------ 1725
Query: 202 IPIVFHTGFMVIFTLYSLYG------LSLIALAFLMSVLIRKPMLAGL---AGFLFTVFW 252
+P+ F G + IF L + Y +SL+ L F + +LAGL G F +
Sbjct: 1726 VPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYV 1785
Query: 253 GCLGFTVLYRQLPLSLGWVLSLLSP---------------------FAFTAGMAQITHLD 291
F + + LS+ + LS P F F G+ +++
Sbjct: 1786 CVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQ 1845
Query: 292 NYLS-----GVIFPDPSGDSYKMIATFFILAFD-TLFYLIFTLYFERVLPDKDGHGDSPL 345
+ L GV +P+ + + K+ A F L T+F+ + L E ++ L
Sbjct: 1846 SVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLR------L 1899
Query: 346 FFLKSSFWSKHQNTHHEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTG 405
FF K F S H I E+E + E + EF + +++ + K Y
Sbjct: 1900 FFRK--FNSSH--VRETIDEDE--DVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHK 1950
Query: 406 KVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDME 465
K+ A+ I I G+ +LG NGAGK+T+ +L+G + + G+ I N + + ++
Sbjct: 1951 KIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN-KTGSLGHVD 2009
Query: 466 EIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIA 525
+G+CPQ + D +TV E+L +A++ GI K++++ V +++ L + +D
Sbjct: 2010 SHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRAT 2069
Query: 526 KKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRL-ILFSTQ 584
S G KRKL+ +A++G P +LLLDEP++G+DP S+ +W ++ E ++ ++ ++
Sbjct: 2070 SMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2129
Query: 585 FMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLH-RNEMCDTEKITSLIKQH 643
M+E + L R + NGK +C GS +K ++G G+ + +H +N E +T ++ H
Sbjct: 2130 SMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLH 2189
Query: 644 IPDAKLTTESEEKLVYSLPLEK---TNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLN 700
P L + L Y +P+ N F L ++ + I N+ VS T+L EVF+N
Sbjct: 2190 FPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALN---ITNFLVSQTTLEEVFIN 2246
Score = 158 bits (399), Expect = 4e-38
Identities = 107/317 (33%), Positives = 161/317 (50%), Gaps = 19/317 (5%)
Query: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDN 1278
K+A+ N++ +G + LLG NGAGK+T+I M+TG +AG + + G ++
Sbjct: 1040 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGK--DIKTDLHT 1097
Query: 1279 SLKFLGYCPQENSLWPKLTMKEHLELYAAVK--GLGKEDAALSISRLVEALKLQEQLKAP 1336
K +G C Q + L+ LT KEHL LY ++K K+ + R ++ L
Sbjct: 1098 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR 1157
Query: 1337 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNK-ERGTLL 1395
V TLS G+KRKL ++++G VV+LDEP TG+DP ++ +W ++ KNK R +L
Sbjct: 1158 VGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVIS---KNKTARTIIL 1214
Query: 1396 TTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI-KMKEPT-------QV 1447
+TH++ EAE + DR+A + G LRC GS +LK FG Y L + K K P
Sbjct: 1215 STHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDT 1274
Query: 1448 EALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQ---TFNLEEYSL 1504
A+ I P+A +E + Y LP L A+ N+ Y +
Sbjct: 1275 MAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGI 1334
Query: 1505 SQATLEQVFLELCKEQE 1521
S T+E+VFL L KE +
Sbjct: 1335 SDTTVEEVFLNLTKESQ 1351
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 277 bits (709), Expect = 5e-74
Identities = 189/662 (28%), Positives = 328/662 (49%), Gaps = 54/662 (8%)
Query: 86 KGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSFS 145
+ F+ Q +I AIIE+ T + E V I P K + + +V
Sbjct: 1019 RAFIYLQDSIERAIIELQTGRNSQEIAVQVQAIPY---PCFMKDNFLTSVSYSLPIVLMV 1075
Query: 146 SFIYFASLNVAR----ERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITS 201
+++ F + V + + + + M +MG+ + + +W + + F+ + + + +++
Sbjct: 1076 AWVVFIAAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIESVGFLLVTIVILIIILKF 1135
Query: 202 IPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTV--FWGCLGFTV 259
I+ T ++F +S Y S+IA+++L+SV +A L G L + F+ +
Sbjct: 1136 GNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLVT 1195
Query: 260 LYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATFF----- 314
+ +L L +SLLSP AF+ I + G+ + + + T F
Sbjct: 1196 VENELSYVLKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCC 1255
Query: 315 ILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWS--------KHQNTHHEIFEN 366
++ D+ Y + Y V P G F + S+W K + ++ +F N
Sbjct: 1256 LILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTN 1315
Query: 367 --------EINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIY 418
+PE+ + EP + + + V K Y K A+ + + Y
Sbjct: 1316 IMMQNTNPSASPEYMFSSNIEPEPKDL--TVGVALHGVTKIYGSKV----AVDNLNLNFY 1369
Query: 419 EGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFN 478
EG IT++LG NGAGK+T +++L+GL ++ G+ +Y + TD+ +RKN+G C Q +
Sbjct: 1370 EGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIK--TDLHTVRKNMGVCMQHD 1427
Query: 479 FQFDFLTVRENLRVFAKIKGIQ--PKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKL 536
F +LT +E+L ++ IK K++ +EVKR + + + S + LSGG KRKL
Sbjct: 1428 VLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKL 1487
Query: 537 TLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRK 596
++ IA++G +V++LDEP+ G+DP SR +W ++ ++K R I+ ST +DEA++L+DR
Sbjct: 1488 SISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRI 1547
Query: 597 VFLSNGKLKCAGSSLFLKRKWGIGYHL--------SLHRNEMCDTEKITSLIKQHIPDAK 648
FL G L+C GS +LK +G GYHL +L+ N +CDT +T++I+ H+P+A
Sbjct: 1548 AFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAY 1607
Query: 649 LTTESEEKLVYSLPLEKTNKFPDLYSDLDKCSDQGIRN-----YAVSVTSLNEVFLNLEG 703
L + +LVY LP T K Y L + D G+ + Y +S T++ EVFLNL
Sbjct: 1608 LKEDIGGELVYVLPPFST-KVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTK 1666
Query: 704 KS 705
+S
Sbjct: 1667 ES 1668
Score = 237 bits (604), Expect = 7e-62
Identities = 178/598 (29%), Positives = 302/598 (50%), Gaps = 67/598 (11%)
Query: 955 ISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFL-ILFSIHLIYYFIFLGFQLSWELM 1013
+ +++ + ISG+ + YW + D+ Y + + FSI +I F F L
Sbjct: 2009 VREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLG 2068
Query: 1014 FV-LVVCIIGCAVSLIFLTYVLSFIFRKWRKNNGFWSFGFFIILICV-------STIMVS 1065
V L++ + G A Y+L+ +F + + FI +CV S + +S
Sbjct: 2069 AVSLLLLLFGYAT--FSWMYLLAGLFHE--------TGMAFITYVCVNLFFGINSIVSLS 2118
Query: 1066 TQY------------EKLNLILCMIFI--PSFTLLGYVMLLIQ-----LDFMRNLD-SLD 1105
Y E ++ L IF+ P F GY ++ + LDF++
Sbjct: 2119 VVYFLSKEKPNDPTLELISETLKRIFLIFPQF-CFGYGLIELSQQQSVLDFLKAYGVEYP 2177
Query: 1106 NRINEVNKTILLTTLIPYLQSVIFLFVIRCLEMKYGNEIMNKDPVFRISPRSRE-THPNP 1164
N E+NK L + + F +R L +N+ + ++ R+ +
Sbjct: 2178 NETFEMNK--LGAMFVALVSQGTMFFSLRLL--------INESLIKKLRLFFRKFNSSHV 2227
Query: 1165 EEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYETKKSCFSTRKKKIAIRN 1224
E +EDEDV+AER++ + E ++ CL K Y KK IA+ N
Sbjct: 2228 RETIDEDEDVRAERLRVESGAA-----EFDLVQLYCLTKTYQ-------LIHKKIIAVNN 2275
Query: 1225 VSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSLKFLG 1284
+S + GE GLLG NGAGK+T KM+TG P++G ++++ S+ D+ +G
Sbjct: 2276 ISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHV-DSHSSLVG 2334
Query: 1285 YCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGI 1344
YCPQE++L +T++EHL YA V G+ ++D ++ +L+ L L S G
Sbjct: 2335 YCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRATSMCSYGT 2394
Query: 1345 KRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAE 1404
KRKL L+++G PS++LLDEP +GMDP+ ++ +W+I+ V+NK +LT+H M E E
Sbjct: 2395 KRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNK-CSVILTSHSMEECE 2453
Query: 1405 AVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKL-FPQAAW 1463
A+C R+A+MV+G +CIGS+QH+K++FGR + +++ +K T+ ++L FP+
Sbjct: 2454 ALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLHFPKTYL 2513
Query: 1464 QERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKEQE 1521
++++ S++ Y +PV ++ F LE K N+ + +SQ TLE+VF+ K+Q+
Sbjct: 2514 KDQHLSMLEYHVPV-TAGGVANIFDLLETNKTALNITNFLVSQTTLEEVFINFAKDQK 2570
Score = 181 bits (458), Expect = 6e-45
Identities = 156/600 (26%), Positives = 280/600 (46%), Gaps = 75/600 (12%)
Query: 142 VSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITS 201
V+ +SF+ + V + K K+L + G+ + +W++ FI+ M ++
Sbjct: 1999 VTTASFVTYV---VREHQTKAKQLQHISGIGVTCYWVT------NFIYDMVFYL------ 2043
Query: 202 IPIVFHTGFMVIFTLYSLYG------LSLIALAFLMSVLIRKPMLAGL---AGFLFTVFW 252
+P+ F G + IF L + Y +SL+ L F + +LAGL G F +
Sbjct: 2044 VPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYV 2103
Query: 253 GCLGFTVLYRQLPLSLGWVLSLLSP---------------------FAFTAGMAQITHLD 291
F + + LS+ + LS P F F G+ +++
Sbjct: 2104 CVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFCFGYGLIELSQQQ 2163
Query: 292 NYLS-----GVIFPDPSGDSYKMIATFFILAFD-TLFYLIFTLYFERVLPDKDGHGDSPL 345
+ L GV +P+ + + K+ A F L T+F+ + L E ++ L
Sbjct: 2164 SVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLLINESLIKKLR------L 2217
Query: 346 FFLKSSFWSKHQNTHHEIFENEINPEHSSDDSFEPVSPEFHGKEAIRIRNVIKEYNGKTG 405
FF K F S H I E+E + E + EF + +++ + K Y
Sbjct: 2218 FFRK--FNSSH--VRETIDEDE--DVRAERLRVESGAAEF---DLVQLYCLTKTYQLIHK 2268
Query: 406 KVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDME 465
K+ A+ I I G+ +LG NGAGK+T+ +L+G + + G+ I N + + ++
Sbjct: 2269 KIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRN-KTGSLGHVD 2327
Query: 466 EIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIA 525
+G+CPQ + D +TV E+L +A++ GI K++++ V +++ L + +D
Sbjct: 2328 SHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLMPFKDRAT 2387
Query: 526 KKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRL-ILFSTQ 584
S G KRKL+ +A++G P +LLLDEP++G+DP S+ +W ++ E ++ ++ ++
Sbjct: 2388 SMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVILTSH 2447
Query: 585 FMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLH-RNEMCDTEKITSLIKQH 643
M+E + L R + NGK +C GS +K ++G G+ + +H +N E +T ++ H
Sbjct: 2448 SMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVTMETLTKFMQLH 2507
Query: 644 IPDAKLTTESEEKLVYSLPLEK---TNKFPDLYSDLDKCSDQGIRNYAVSVTSLNEVFLN 700
P L + L Y +P+ N F L ++ + I N+ VS T+L EVF+N
Sbjct: 2508 FPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALN---ITNFLVSQTTLEEVFIN 2564
Score = 158 bits (399), Expect = 4e-38
Identities = 107/317 (33%), Positives = 161/317 (50%), Gaps = 19/317 (5%)
Query: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDN 1278
K+A+ N++ +G + LLG NGAGK+T+I M+TG +AG + + G ++
Sbjct: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGK--DIKTDLHT 1415
Query: 1279 SLKFLGYCPQENSLWPKLTMKEHLELYAAVK--GLGKEDAALSISRLVEALKLQEQLKAP 1336
K +G C Q + L+ LT KEHL LY ++K K+ + R ++ L
Sbjct: 1416 VRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKR 1475
Query: 1337 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNK-ERGTLL 1395
V TLS G+KRKL ++++G VV+LDEP TG+DP ++ +W ++ KNK R +L
Sbjct: 1476 VGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVIS---KNKTARTIIL 1532
Query: 1396 TTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI-KMKEPT-------QV 1447
+TH++ EAE + DR+A + G LRC GS +LK FG Y L + K K P
Sbjct: 1533 STHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDT 1592
Query: 1448 EALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQ---TFNLEEYSL 1504
A+ I P+A +E + Y LP L A+ N+ Y +
Sbjct: 1593 MAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGI 1652
Query: 1505 SQATLEQVFLELCKEQE 1521
S T+E+VFL L KE +
Sbjct: 1653 SDTTVEEVFLNLTKESQ 1669
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 274 bits (700), Expect = 6e-73
Identities = 229/789 (29%), Positives = 373/789 (47%), Gaps = 63/789 (7%)
Query: 45 SYRLKFN--WGYRIPVIKEHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAINAAIIEV 102
SY ++ N + R V+K S W H + + F Q I AII V
Sbjct: 3485 SYTIRTNVLYSVRTDVVKNPS------WKFHPQNLPADGFKYNYVFAPLQDMIERAIILV 3538
Query: 103 TTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSFSSFIYFASLN---VARER 159
T +E P S + N F F ++ + + AS+ V +
Sbjct: 3539 QTGQEALEPAAQTQAA--PYPCHTSDLFLNNVGFFFPLIMMLTWMVSVASMVRKLVYEQE 3596
Query: 160 GKFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITSIPIVFHTGFMVIFTLYSL 219
+ ++ M +MG+ +L+W L + + I S +A+V+ + I H+ ++F
Sbjct: 3597 IQIEEYMRMMGVHPVIHFLAWFLENMAVLTISSATLAIVLKTSGIFAHSNTFIVFLFLLD 3656
Query: 220 YGLSLIALAFLMSVLIRKPMLAGLAGFLFTV--FWGCLGFTVLYRQLPLSLGWVLSLLSP 277
+G+S++ L++L+S + A L L + F + VL+ QL L LLS
Sbjct: 3657 FGMSVVMLSYLLSAFFSQANTAALCTSLVYMISFLPYIVLLVLHNQLSFVNQTFLCLLST 3716
Query: 278 FAFTAGMAQITHLDNYLSGVIFPDPSGDSYKMIATF----FILAFDTLFYLIFTLYFERV 333
AF G+ IT L+ +G+ + + + TF +++ FD+ Y + Y +
Sbjct: 3717 TAFGQGVFFITFLEGQETGIQWNNMYQALEQGGMTFGWVCWMILFDSSLYFLCGWYLSNL 3776
Query: 334 LPDKDGHGDSPLFFLKSSFW--------------SKHQNTHHEIFENEINPEHSSDDSFE 379
+P G F +S+W S +E F+N+ + + + E
Sbjct: 3777 IPGTFGLRKPWYFPFTASYWKSVGFLVEKRQYFLSSSLFFFNENFDNKGSSLQNREGELE 3836
Query: 380 PVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNI 439
+P + + +V KEY G V+ L F Y QITA+LG NGAGK+T++++
Sbjct: 3837 GSAP------GVTLVSVTKEYEGHKAVVQDLSLTF---YRDQITALLGTNGAGKTTIISM 3887
Query: 440 LSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGI 499
L+GL T G+ I L TD+ +R +G CPQ + D LTVRE+L +FA IK
Sbjct: 3888 LTGLHPPTSGTIIINGKNLQ--TDLSRVRMELGVCPQQDILLDNLTVREHLLLFASIKAP 3945
Query: 500 Q--PKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAG 557
Q KE+ Q+V + + ++D+ Q + LSGG KRKL+LGIA +G + ++LDEPT+G
Sbjct: 3946 QWTKKELHQQVNQTLQDVDLTQHQHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSG 4005
Query: 558 LDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKW 617
+DP SRH +W +L +++ R I+F+T +DEA+ L+DR L +G+L+C G LK +
Sbjct: 4006 VDPCSRHSLWDILLKYREGRTIIFTTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAY 4065
Query: 618 GIGYHLSLHR-------NEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNK-- 668
G G L+L R +++ D +TSLIK +IP A L S +L Y++P + T+K
Sbjct: 4066 GQGLRLTLTRQPSVLEAHDLKDMACVTSLIKIYIPQAFLKDSSGSELTYTIP-KDTDKAC 4124
Query: 669 FPDLYSDLDKCSDQ-GIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEKIHVTRNTG 727
L+ LD+ Q + Y +S T+L EVFL L + + + +G + ++ R TG
Sbjct: 4125 LKGLFQALDENLHQLHLTGYGISDTTLEEVFLMLL-QDSNKKSHIALGTESELQNHRPTG 4183
Query: 728 DESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLRRERRALLCLLLVLGIAFIP 787
S C V L R Q+ A+ R + R ++ L LL L + F+
Sbjct: 4184 HLSG----YCGSLARPATVQGVQLLRAQVAAILARRLRRTLRAGKSTLADLL-LPVLFVA 4238
Query: 788 IILEKIMYK 796
+ + M +
Sbjct: 4239 LAMGLFMVR 4247
Score = 197 bits (501), Expect = 7e-50
Identities = 172/627 (27%), Positives = 296/627 (47%), Gaps = 61/627 (9%)
Query: 922 SRDDIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQA 981
++D I+ + ++ ++L + +S IG S + D + ISGL YW
Sbjct: 4445 NKDKILESIRQCGVALCIVLGFSILSASIGSSVVRDRVIGAKRLQHISGLGYRMYWFTNF 4504
Query: 982 LVDIPLYFL-ILFSIHLIYYFIFLGFQLSWELMFV-LVVCIIGCAV-------------- 1025
L D+ Y + + + +I F F L L++ + G A
Sbjct: 4505 LYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSLFGYATLPWMYLMSRIFSSS 4564
Query: 1026 SLIFLTYV-LSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIF--IPS 1082
+ F++YV L+FIF G + I+ ++ I + + + +L +F P
Sbjct: 4565 DVAFISYVSLNFIF-------GLCTMLITIMPRLLAIISKAKNLQNIYDVLKWVFTIFPQ 4617
Query: 1083 FTL-LGYVMLL---IQLDFMRNLDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLEM 1138
F L G V L I+ D N +D+ ++ L + L ++R L
Sbjct: 4618 FCLGQGLVELCYNQIKYDLTHNF-GIDSYVSPFEMNFLGWIFVQLASQGTVLLLLRVL-- 4674
Query: 1139 KYGNEIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITA 1198
++ D + PR T + +D DV+ E + T + ++
Sbjct: 4675 ------LHWDLLRW--PRGHSTLQGTVK-SSKDTDVEKEEKRVFEGRTNGD-----ILVL 4720
Query: 1199 SCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP 1258
L K Y ++ IA++++S + KGE GLLG NGAGKST+ KM+ G
Sbjct: 4721 YNLSKHYRRFFQNI-------IAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVSL 4773
Query: 1259 TAGVVVLQ---GSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKED 1315
T+G +++ G + + +GYCPQ+++L LT EHL Y +++G+ ++
Sbjct: 4774 TSGHAIIRTPMGDAVDLSSAGTAGV-LIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQC 4832
Query: 1316 AALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQ 1375
L+ L L+ PV T S G KRKL L+++G P ++LLDEP +GMDP +
Sbjct: 4833 IPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSK 4892
Query: 1376 QQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDY 1435
+ +WQ + V+ + +LT+H M E EA+C R+A+MV+G+ +C+GS QH+KN+FG Y
Sbjct: 4893 RYLWQTIMKEVR-EGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGDGY 4951
Query: 1436 LLEIKMKEPTQVEALHTEILKL-FPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMK 1494
+++ + + ++ LKL FP ++ ++ +L+ Y +P + L+ F +E K
Sbjct: 4952 TVKVWLCKEANQHCTVSDHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCLADLFKVIENNK 5010
Query: 1495 QTFNLEEYSLSQATLEQVFLELCKEQE 1521
N++ YS++Q TLEQVF+ EQ+
Sbjct: 5011 TFLNIKHYSINQTTLEQVFINFASEQQ 5037
Score = 159 bits (402), Expect = 2e-38
Identities = 101/313 (32%), Positives = 175/313 (55%), Gaps = 18/313 (5%)
Query: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDN 1278
K ++++S + ++ LLG NGAGK+T I M+TG PT+G +++ G +++
Sbjct: 3855 KAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTSGTIIINGK--NLQTDLSR 3912
Query: 1279 SLKFLGYCPQENSLWPKLTMKEHLELYAAVKG--LGKEDAALSISRLVEALKLQEQLKAP 1336
LG CPQ++ L LT++EHL L+A++K K++ +++ ++ + L +
Sbjct: 3913 VRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHKQ 3972
Query: 1337 VKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLL- 1395
+ LS G+KRKL ++ +G V+LDEP +G+DP + +W IL +K +E T++
Sbjct: 3973 TRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDIL---LKYREGRTIIF 4029
Query: 1396 TTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVE------- 1448
TTH++ EAEA+ DR+A++ G LRC G LK +G+ L + ++P+ +E
Sbjct: 4030 TTHHLDEAEALSDRVAVLQHGRLRCCGPPFCLKEAYGQGLRLTL-TRQPSVLEAHDLKDM 4088
Query: 1449 ALHTEILKLF-PQAAWQERYSSLMAYKLPVE-DVHPLSRAFFKLEAMKQTFNLEEYSLSQ 1506
A T ++K++ PQA ++ S + Y +P + D L F L+ +L Y +S
Sbjct: 4089 ACVTSLIKIYIPQAFLKDSSGSELTYTIPKDTDKACLKGLFQALDENLHQLHLTGYGISD 4148
Query: 1507 ATLEQVFLELCKE 1519
TLE+VFL L ++
Sbjct: 4149 TTLEEVFLMLLQD 4161
Score = 147 bits (372), Expect = 6e-35
Identities = 136/572 (23%), Positives = 250/572 (43%), Gaps = 60/572 (10%)
Query: 163 KKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVITSIPIV---FHTGFMVIFTLYSL 219
K+L + GL +W + L + F + VI + + F L SL
Sbjct: 4486 KRLQHISGLGYRMYWFTNFLYDMLFYLVSVCLCVAVIVAFQLTAFTFRKNLAATALLLSL 4545
Query: 220 YGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGC--LGFTVLYRQLPLS---------- 267
+G + + +LMS + +A ++ +G + T++ R L +
Sbjct: 4546 FGYATLPWMYLMSRIFSSSDVAFISYVSLNFIFGLCTMLITIMPRLLAIISKAKNLQNIY 4605
Query: 268 --LGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPDPSGDSY------KMIATFFI--LA 317
L WV ++ F G+ ++ + N + + + DSY + F+ +
Sbjct: 4606 DVLKWVFTIFPQFCLGQGLVELCY--NQIKYDLTHNFGIDSYVSPFEMNFLGWIFVQLAS 4663
Query: 318 FDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSDDS 377
T+ L+ L +L GH +KSS + + +FE N +
Sbjct: 4664 QGTVLLLLRVLLHWDLLRWPRGHSTLQ-GTVKSSKDTDVEKEEKRVFEGRTNGD------ 4716
Query: 378 FEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLL 437
+ + N+ K Y + A+Q I I +G+ +LG NGAGKST
Sbjct: 4717 ------------ILVLYNLSKHYRRFFQNIIAVQDISLGIPKGECFGLLGVNGAGKSTTF 4764
Query: 438 NILSGLSVSTEGSATIYNTQLSEITDMEEIRKN---IGFCPQFNFQFDFLTVRENLRVFA 494
+L+G T G A I T + + D+ IG+CPQ + + LT E+L +
Sbjct: 4765 KMLNGEVSLTSGHAII-RTPMGDAVDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYC 4823
Query: 495 KIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEP 554
++GI + + + +I L +++ D SGG KRKL+ +A++G P +LLLDEP
Sbjct: 4824 SLRGIPRQCIPEVAGDLIRRLHLEAHADKPVATYSGGTKRKLSTALALVGKPDILLLDEP 4883
Query: 555 TAGLDPFSRHRVW-SLLKEHKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFL 613
++G+DP S+ +W +++KE + + ++ M+E + L R + NG KC GS +
Sbjct: 4884 SSGMDPCSKRYLWQTIMKEVREGCAAVLTSHSMEECEALCTRLAIMVNGSFKCLGSPQHI 4943
Query: 614 KRKWGIGYHLSL----HRNEMCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKF 669
K ++G GY + + N+ C ++ +K + P + + L Y +P ++
Sbjct: 4944 KNRFGDGYTVKVWLCKEANQHC---TVSDHLKLYFPGIQFKGQHLNLLEYHVP-KRWGCL 4999
Query: 670 PDLYSDLDKCSD-QGIRNYAVSVTSLNEVFLN 700
DL+ ++ I++Y+++ T+L +VF+N
Sbjct: 5000 ADLFKVIENNKTFLNIKHYSINQTTLEQVFIN 5031
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 250 bits (638), Expect = 9e-66
Identities = 199/761 (26%), Positives = 356/761 (46%), Gaps = 95/761 (12%)
Query: 37 GVIFSDTFSY------RLKFNWGYRIPVIKEHSEYTEHCW-----AMHGEIFCYLAKYWL 85
GV+F D + + +K+ I V+++ ++ + W A E F Y+ W
Sbjct: 550 GVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYI---W- 605
Query: 86 KGFVAFQAAINAAIIEVTTNHSVMEELTSVIGI---NMKIPPFISKGE--IMNEWFHFTC 140
GF Q + I T V E + +GI M P F+ I+N F
Sbjct: 606 GGFAYLQDMVEQGI----TRSQVQAE--APVGIYLQQMPYPCFVDDSFMIILNRCFPIFM 659
Query: 141 LVSFSSFIYFASLNVARERG-KFKKLMTVMGLRESAFWLSWGLTYICFIFIMSIFMALVI 199
++++ + ++ E+ + K+ + G+ + W +W L + + + + I
Sbjct: 660 VLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFI 719
Query: 200 TSIPIVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAG--FLFTVFWGCLGF 257
I+ ++ ++F + + I L FL+S K LA FT++ +
Sbjct: 720 MHGRILHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFTLYLPHILC 779
Query: 258 TVLYRQLPLSLGWVLSLLSPFAFTAGMAQITHLDNYLSGVIFPD-----PSGDSYKMIAT 312
++ L +SLLSP AF G + + G+ + + GD + + +
Sbjct: 780 FAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLS 839
Query: 313 FFILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQ--NTHHE-------- 362
++ D Y + Y ++V P G F L+ S+W + +T E
Sbjct: 840 MQMMLLDAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEP 899
Query: 363 IFENEINPEHSS---DDSFEPVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYE 419
+ E +PEH D FE P + + ++N++K + G+ A+ + YE
Sbjct: 900 LTEETEDPEHPEGIHDSFFEREHPGW--VPGVCVKNLVKIFE-PCGR-PAVDRLNITFYE 955
Query: 420 GQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNF 479
QITA LGHNGAGK+T L+IL+GL T G+ + + T ++ +R+++G CPQ N
Sbjct: 956 NQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIE--TSLDAVRQSLGMCPQHNI 1013
Query: 480 QFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLG 539
F LTV E++ +A++KG +E + E++ ++ + + ++ A+ LSGG +RKL++
Sbjct: 1014 LFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVA 1073
Query: 540 IAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADILADRKVFL 599
IA +GD +V++LDEPT+G+DP+SR +W LL +++ R I+ ST MDEAD+L DR +
Sbjct: 1074 IAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAII 1133
Query: 600 SNGKLKCAGSSLFLKRKWGIGYHLSLHR-----------------------NEMC----- 631
+ G+L C+G+ LFLK +G G +L+L R + C
Sbjct: 1134 AQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVD 1193
Query: 632 ----------DTEKITSLIKQHIPDAKLTTESEEKLVYSLPLE--KTNKFPDLYSDLDK- 678
D ++ ++ H+P+AKL ++L++ LP + K + L+ +L++
Sbjct: 1194 DLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEET 1253
Query: 679 CSDQGIRNYAVSVTSLNEVFLNLEGKSAIDEPDFDIGKQEK 719
+D G+ ++ +S T L E+FL + + + P F G Q+K
Sbjct: 1254 LADLGLSSFGISDTPLEEIFLKVT-EDSDSGPLFAGGAQQK 1293
Score = 208 bits (530), Expect = 3e-53
Identities = 179/623 (28%), Positives = 302/623 (48%), Gaps = 84/623 (13%)
Query: 926 IVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDI 985
++ + F+ S L LI V+ K++Q +ISG+ P+ YW L DI
Sbjct: 1686 VIFSMSFVPASFVLYLIQERVNK----------SKHLQ---FISGVSPTTYWVTNFLWDI 1732
Query: 986 PLYFLILFSIHLIYYFIFLGFQ----LSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKW 1041
Y + S L+ IF+GFQ S E + LV ++ ++I + Y SF+F
Sbjct: 1733 MNYSV---SAGLVVG-IFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDV- 1787
Query: 1042 RKNNGFWSFGFFIILICVSTIMVSTQYE---------KLNLIL--CMIFIPSFTLLGYVM 1090
+ + + + I +++ ++ E + N +L +I P F L
Sbjct: 1788 -PSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCL---GR 1843
Query: 1091 LLIQLDFMRNLDSLDNRINEVNKT------ILLTTLIPYLQSVIFLFVIRCLEMKYGNEI 1144
LI L + + + R E + ++ L + + F++ L ++
Sbjct: 1844 GLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRH---- 1899
Query: 1145 MNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKE 1204
F +S E P E +ED+DV ER + +T N + ++ L K
Sbjct: 1900 ------FFLSQWIAE--PTKEPIVDEDDDVAEERQRI---ITGGNKTD--ILRLHELTKI 1946
Query: 1205 YYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVV 1264
Y T A+ + V+ GE GLLG NGAGK+T+ KM+TG T T+G
Sbjct: 1947 YPGTSSP---------AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDAT 1997
Query: 1265 LQGSR--ASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISR 1322
+ G ++ + H N +GYCPQ +++ LT +EHL LYA ++G+ E+ +
Sbjct: 1998 VAGKSILTNISEVHQN----MGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANW 2053
Query: 1323 LVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQIL 1382
+++L L T S G KRKL ++++G P +VLLDEP TGMDP+ ++ +W ++
Sbjct: 2054 SIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVI 2113
Query: 1383 QATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMK 1442
+ ++ + R +LT+H M E EA+C R+A+MV G RC+G+IQHLK+KFG Y++ +K+K
Sbjct: 2114 VSIIR-EGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIK 2172
Query: 1443 EP-----TQVEALHTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTF 1497
P + + FP + +ER+ +++ +++ L+R F L + K +
Sbjct: 2173 SPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSS---LARIFQLLLSHKDSL 2229
Query: 1498 NLEEYSLSQATLEQVFLELCKEQ 1520
+EEYS++Q TL+QVF+ K+Q
Sbjct: 2230 LIEEYSVTQTTLDQVFVNFAKQQ 2252
Score = 151 bits (382), Expect = 4e-36
Identities = 92/319 (28%), Positives = 168/319 (52%), Gaps = 14/319 (4%)
Query: 389 EAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTE 448
+ +R+ + K Y G + A+ + + G+ +LG NGAGK+T +L+G + T
Sbjct: 1936 DILRLHELTKIYPGTSSP--AVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTS 1993
Query: 449 GSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEV 508
G AT+ + +T++ E+ +N+G+CPQF+ + LT RE+L ++A+++G+ +E+E+
Sbjct: 1994 GDATVAGKSI--LTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVA 2051
Query: 509 KRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWS 568
I L + D +A SGG KRKL+ IA++G P ++LLDEPT G+DP +R +W+
Sbjct: 2052 NWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWN 2111
Query: 569 LLKE-HKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHR 627
++ + R ++ ++ M+E + L R + G +C G+ LK K+G GY +++
Sbjct: 2112 VIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKI 2171
Query: 628 NE-----MCDTEKITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNK-FPDLYSDLDKCSD 681
+ D + + + P + L + + + F L S D
Sbjct: 2172 KSPKDDLLPDLNPVEQFFQGNFPGSVQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLL- 2230
Query: 682 QGIRNYAVSVTSLNEVFLN 700
I Y+V+ T+L++VF+N
Sbjct: 2231 --IEEYSVTQTTLDQVFVN 2247
Score = 150 bits (378), Expect = 1e-35
Identities = 99/343 (28%), Positives = 168/343 (48%), Gaps = 44/343 (12%)
Query: 1221 AIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASVRQQHDNSL 1280
A+ ++ + ++ LGHNGAGK+T++ ++TG PT+G V++ G + D
Sbjct: 945 AVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGR--DIETSLDAVR 1002
Query: 1281 KFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTL 1340
+ LG CPQ N L+ LT+ EH+ YA +KG +E+A L + ++E L + + L
Sbjct: 1003 QSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDL 1062
Query: 1341 SEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYM 1400
S G++RKL ++ +G+ VV+LDEP +G+DP ++ +W +L R +++TH+M
Sbjct: 1063 SGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLL--LKYRSGRTIIMSTHHM 1120
Query: 1401 SEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEI--KMKE--------------- 1443
EA+ + DR+A++ G L C G+ LKN FG L + KMK
Sbjct: 1121 DEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQRKGSEGTCSCS 1180
Query: 1444 --------PTQVEALHTE-------------ILKLFPQAAWQERYSSLMAYKLPVEDVHP 1482
P V+ L E +L P+A E + + LP ++
Sbjct: 1181 SKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKH 1240
Query: 1483 LSRA--FFKLEAMKQTFNLEEYSLSQATLEQVFLELCKEQELG 1523
+ A F +LE L + +S LE++FL++ ++ + G
Sbjct: 1241 RAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSG 1283
>gi|169210363 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 120 bits (302), Expect = 8e-27
Identities = 56/164 (34%), Positives = 100/164 (60%), Gaps = 1/164 (0%)
Query: 1296 LTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSIL 1355
+T +E + +YA + G+ + L +++ + +L+L+ + T SEG KR+L ++++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1356 GNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVS 1415
G SV+ LDEP TGMDP ++ +W ++ T + + ++T+H M E +A+C +A+MV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1416 GTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFP 1459
G C+GS QHLK+KFG Y+L++K+K ++E + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 82.4 bits (202), Expect = 3e-15
Identities = 43/143 (30%), Positives = 79/143 (55%), Gaps = 1/143 (0%)
Query: 484 LTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAIL 543
+T +E + ++A+I G+ ++ V + + L+++S + S G KR+L+ IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 544 GDPQVLLLDEPTAGLDPFSRHRVWSLL-KEHKVDRLILFSTQFMDEADILADRKVFLSNG 602
G V+ LDEP+ G+DP +R +W+++ K + + I+ ++ M+E D L + G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 603 KLKCAGSSLFLKRKWGIGYHLSL 625
K C GS LK K+G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|169210679 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 120 bits (302), Expect = 8e-27
Identities = 56/164 (34%), Positives = 100/164 (60%), Gaps = 1/164 (0%)
Query: 1296 LTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSIL 1355
+T +E + +YA + G+ + L +++ + +L+L+ + T SEG KR+L ++++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1356 GNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVS 1415
G SV+ LDEP TGMDP ++ +W ++ T + + ++T+H M E +A+C +A+MV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1416 GTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFP 1459
G C+GS QHLK+KFG Y+L++K+K ++E + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 82.4 bits (202), Expect = 3e-15
Identities = 43/143 (30%), Positives = 79/143 (55%), Gaps = 1/143 (0%)
Query: 484 LTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAIL 543
+T +E + ++A+I G+ ++ V + + L+++S + S G KR+L+ IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 544 GDPQVLLLDEPTAGLDPFSRHRVWSLL-KEHKVDRLILFSTQFMDEADILADRKVFLSNG 602
G V+ LDEP+ G+DP +R +W+++ K + + I+ ++ M+E D L + G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 603 KLKCAGSSLFLKRKWGIGYHLSL 625
K C GS LK K+G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|169209894 PREDICTED: similar to hCG18626 [Homo sapiens]
Length = 171
Score = 120 bits (302), Expect = 8e-27
Identities = 56/164 (34%), Positives = 100/164 (60%), Gaps = 1/164 (0%)
Query: 1296 LTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSIL 1355
+T +E + +YA + G+ + L +++ + +L+L+ + T SEG KR+L ++++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 1356 GNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVS 1415
G SV+ LDEP TGMDP ++ +W ++ T + + ++T+H M E +A+C +A+MV
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKT-RESGKAIVMTSHSMEECDALCTSLAIMVQ 119
Query: 1416 GTLRCIGSIQHLKNKFGRDYLLEIKMKEPTQVEALHTEILKLFP 1459
G C+GS QHLK+KFG Y+L++K+K ++E + FP
Sbjct: 120 GKFTCLGSPQHLKSKFGNIYILKVKVKTEDKLEDFKCYVATTFP 163
Score = 82.4 bits (202), Expect = 3e-15
Identities = 43/143 (30%), Positives = 79/143 (55%), Gaps = 1/143 (0%)
Query: 484 LTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAIL 543
+T +E + ++A+I G+ ++ V + + L+++S + S G KR+L+ IA++
Sbjct: 1 MTAQEIMIMYARIWGVSEPQIGLYVNKCLNSLELESHAARLINTYSEGNKRRLSTAIALM 60
Query: 544 GDPQVLLLDEPTAGLDPFSRHRVWSLL-KEHKVDRLILFSTQFMDEADILADRKVFLSNG 602
G V+ LDEP+ G+DP +R +W+++ K + + I+ ++ M+E D L + G
Sbjct: 61 GRSSVIFLDEPSTGMDPVARRLLWNMVTKTRESGKAIVMTSHSMEECDALCTSLAIMVQG 120
Query: 603 KLKCAGSSLFLKRKWGIGYHLSL 625
K C GS LK K+G Y L +
Sbjct: 121 KFTCLGSPQHLKSKFGNIYILKV 143
>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
sapiens]
Length = 673
Score = 92.0 bits (227), Expect = 4e-18
Identities = 76/277 (27%), Positives = 144/277 (51%), Gaps = 21/277 (7%)
Query: 410 LQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQL---SEITDMEE 466
+Q + F + GQ+ AI+G +G G+++LL++++G I + Q+ + + +
Sbjct: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRG----HGGKIKSGQIWINGQPSSPQL 143
Query: 467 IRKNIGFCPQFNFQFDFLTVRENLRVFAKIK---GIQPKEVEQEVKRIIMELDMQSIQD- 522
+RK + Q N LTVRE L A+++ + ++ V+ +I EL ++ D
Sbjct: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADT 203
Query: 523 ----IIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHR-VWSLLKEHKVDR 577
+ + LSGG++R++++G+ +L +P +L+LDEPT+GLD F+ H V +L + K +R
Sbjct: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
Query: 578 LILFSTQFMDEADI--LADRKVFLSNGKLKCAGSSLFLKRKW-GIGYHLSLHRNEMCDTE 634
L+L S +DI L D + +++G G++ + + + IGY + N
Sbjct: 264 LVLISLH-QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYV 322
Query: 635 KITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPD 671
+TS I + + +L T + + + +L LEK D
Sbjct: 323 DLTS-IDRRSREQELATREKAQSLAALFLEKVRDLDD 358
Score = 76.3 bits (186), Expect = 2e-13
Identities = 58/225 (25%), Positives = 113/225 (50%), Gaps = 17/225 (7%)
Query: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCT---KPTAGVVVLQGSRASVRQQ 1275
++ I+N+SF V+ G++L ++G +G G+++ + +ITG K +G + + G +S +
Sbjct: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV 144
Query: 1276 HDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVK---GLGKEDAALSISRLVEALKLQEQ 1332
K + + Q N L P LT++E L A ++ + + ++ L+L++
Sbjct: 145 R----KCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQC 200
Query: 1333 LKAPV-----KTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVK 1387
V + LS G +R++ + +L NP +++LDEP +G+D + + L K
Sbjct: 201 ADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAK 260
Query: 1388 NKERGTLLTTHY-MSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKF 1431
R L++ H S+ + D + +M SGT +G+ QH+ F
Sbjct: 261 G-NRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 89.0 bits (219), Expect = 3e-17
Identities = 60/170 (35%), Positives = 92/170 (54%), Gaps = 4/170 (2%)
Query: 403 KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEIT 462
K G L+GI G++ AI+G +GAGKSTL+NIL+G + A + N
Sbjct: 91 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN---GLPR 147
Query: 463 DMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQ 521
D+ RK + Q + LTV+E + V A +K + E +E VK I+ L + S
Sbjct: 148 DLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCA 207
Query: 522 DIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLK 571
+ LSGGQ+++L + + ++ +P V+ DEPT+GLD S +V SL+K
Sbjct: 208 NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 257
Score = 66.2 bits (160), Expect = 2e-10
Identities = 51/190 (26%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 1216 RKK--KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP-TAGVVVLQGSRASV 1272
RKK K ++ +S GE++ ++G +GAGKST + ++ G + G V++ G +
Sbjct: 90 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDL 149
Query: 1273 RQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS-ISRLVEALKLQE 1331
R S Y Q++ L P LT++E + + A +K K++ + ++ AL L
Sbjct: 150 RCFRKVSC----YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 205
Query: 1332 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKER 1391
+LS G +++L L ++ NP V+ DEP +G+D Q+ +++ + R
Sbjct: 206 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GR 264
Query: 1392 GTLLTTHYMS 1401
+ T H S
Sbjct: 265 SIICTIHQPS 274
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 89.0 bits (219), Expect = 3e-17
Identities = 60/170 (35%), Positives = 92/170 (54%), Gaps = 4/170 (2%)
Query: 403 KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEIT 462
K G L+GI G++ AI+G +GAGKSTL+NIL+G + A + N
Sbjct: 72 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN---GLPR 128
Query: 463 DMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQ 521
D+ RK + Q + LTV+E + V A +K + E +E VK I+ L + S
Sbjct: 129 DLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCA 188
Query: 522 DIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLK 571
+ LSGGQ+++L + + ++ +P V+ DEPT+GLD S +V SL+K
Sbjct: 189 NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 238
Score = 66.2 bits (160), Expect = 2e-10
Identities = 51/190 (26%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 1216 RKK--KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP-TAGVVVLQGSRASV 1272
RKK K ++ +S GE++ ++G +GAGKST + ++ G + G V++ G +
Sbjct: 71 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDL 130
Query: 1273 RQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS-ISRLVEALKLQE 1331
R S Y Q++ L P LT++E + + A +K K++ + ++ AL L
Sbjct: 131 RCFRKVSC----YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 186
Query: 1332 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKER 1391
+LS G +++L L ++ NP V+ DEP +G+D Q+ +++ + R
Sbjct: 187 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GR 245
Query: 1392 GTLLTTHYMS 1401
+ T H S
Sbjct: 246 SIICTIHQPS 255
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 89.0 bits (219), Expect = 3e-17
Identities = 60/170 (35%), Positives = 92/170 (54%), Gaps = 4/170 (2%)
Query: 403 KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEIT 462
K G L+GI G++ AI+G +GAGKSTL+NIL+G + A + N
Sbjct: 96 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN---GLPR 152
Query: 463 DMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQ 521
D+ RK + Q + LTV+E + V A +K + E +E VK I+ L + S
Sbjct: 153 DLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCA 212
Query: 522 DIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLK 571
+ LSGGQ+++L + + ++ +P V+ DEPT+GLD S +V SL+K
Sbjct: 213 NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 262
Score = 66.2 bits (160), Expect = 2e-10
Identities = 51/190 (26%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 1216 RKK--KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP-TAGVVVLQGSRASV 1272
RKK K ++ +S GE++ ++G +GAGKST + ++ G + G V++ G +
Sbjct: 95 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDL 154
Query: 1273 RQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS-ISRLVEALKLQE 1331
R S Y Q++ L P LT++E + + A +K K++ + ++ AL L
Sbjct: 155 RCFRKVSC----YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 210
Query: 1332 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKER 1391
+LS G +++L L ++ NP V+ DEP +G+D Q+ +++ + R
Sbjct: 211 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GR 269
Query: 1392 GTLLTTHYMS 1401
+ T H S
Sbjct: 270 SIICTIHQPS 279
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 89.0 bits (219), Expect = 3e-17
Identities = 60/170 (35%), Positives = 92/170 (54%), Gaps = 4/170 (2%)
Query: 403 KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEIT 462
K G L+GI G++ AI+G +GAGKSTL+NIL+G + A + N
Sbjct: 105 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN---GLPR 161
Query: 463 DMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQ 521
D+ RK + Q + LTV+E + V A +K + E +E VK I+ L + S
Sbjct: 162 DLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCA 221
Query: 522 DIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLK 571
+ LSGGQ+++L + + ++ +P V+ DEPT+GLD S +V SL+K
Sbjct: 222 NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 271
Score = 66.2 bits (160), Expect = 2e-10
Identities = 51/190 (26%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 1216 RKK--KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP-TAGVVVLQGSRASV 1272
RKK K ++ +S GE++ ++G +GAGKST + ++ G + G V++ G +
Sbjct: 104 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDL 163
Query: 1273 RQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS-ISRLVEALKLQE 1331
R S Y Q++ L P LT++E + + A +K K++ + ++ AL L
Sbjct: 164 RCFRKVSC----YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 219
Query: 1332 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKER 1391
+LS G +++L L ++ NP V+ DEP +G+D Q+ +++ + R
Sbjct: 220 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GR 278
Query: 1392 GTLLTTHYMS 1401
+ T H S
Sbjct: 279 SIICTIHQPS 288
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 89.0 bits (219), Expect = 3e-17
Identities = 60/170 (35%), Positives = 92/170 (54%), Gaps = 4/170 (2%)
Query: 403 KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEIT 462
K G L+GI G++ AI+G +GAGKSTL+NIL+G + A + N
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN---GLPR 150
Query: 463 DMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQ 521
D+ RK + Q + LTV+E + V A +K + E +E VK I+ L + S
Sbjct: 151 DLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCA 210
Query: 522 DIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLK 571
+ LSGGQ+++L + + ++ +P V+ DEPT+GLD S +V SL+K
Sbjct: 211 NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 260
Score = 66.2 bits (160), Expect = 2e-10
Identities = 51/190 (26%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 1216 RKK--KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP-TAGVVVLQGSRASV 1272
RKK K ++ +S GE++ ++G +GAGKST + ++ G + G V++ G +
Sbjct: 93 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDL 152
Query: 1273 RQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS-ISRLVEALKLQE 1331
R S Y Q++ L P LT++E + + A +K K++ + ++ AL L
Sbjct: 153 RCFRKVSC----YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 208
Query: 1332 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKER 1391
+LS G +++L L ++ NP V+ DEP +G+D Q+ +++ + R
Sbjct: 209 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GR 267
Query: 1392 GTLLTTHYMS 1401
+ T H S
Sbjct: 268 SIICTIHQPS 277
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 89.0 bits (219), Expect = 3e-17
Identities = 60/170 (35%), Positives = 92/170 (54%), Gaps = 4/170 (2%)
Query: 403 KTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEIT 462
K G L+GI G++ AI+G +GAGKSTL+NIL+G + A + N
Sbjct: 94 KKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLIN---GLPR 150
Query: 463 DMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQ 521
D+ RK + Q + LTV+E + V A +K + E +E VK I+ L + S
Sbjct: 151 DLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCA 210
Query: 522 DIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLK 571
+ LSGGQ+++L + + ++ +P V+ DEPT+GLD S +V SL+K
Sbjct: 211 NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 260
Score = 66.2 bits (160), Expect = 2e-10
Identities = 51/190 (26%), Positives = 93/190 (48%), Gaps = 9/190 (4%)
Query: 1216 RKK--KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP-TAGVVVLQGSRASV 1272
RKK K ++ +S GE++ ++G +GAGKST + ++ G + G V++ G +
Sbjct: 93 RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDL 152
Query: 1273 RQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALS-ISRLVEALKLQE 1331
R S Y Q++ L P LT++E + + A +K K++ + ++ AL L
Sbjct: 153 RCFRKVSC----YIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLS 208
Query: 1332 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKER 1391
+LS G +++L L ++ NP V+ DEP +G+D Q+ +++ + R
Sbjct: 209 CANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQG-GR 267
Query: 1392 GTLLTTHYMS 1401
+ T H S
Sbjct: 268 SIICTIHQPS 277
>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 82.8 bits (203), Expect = 2e-15
Identities = 65/213 (30%), Positives = 105/213 (49%), Gaps = 9/213 (4%)
Query: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
++ I+G +GAGKST +NIL+G S + N + E+ RK + Q +
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPREL---RTFRKMSCYIMQDDML 152
Query: 481 FDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQDIIAKKLSGGQKRKLTLG 539
LTV E + V A +K + +EV++E V I+ L + S LSGGQ+++L +
Sbjct: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
Query: 540 IAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADI--LADRKV 597
+ ++ +P V+ DEPT+GLD S +V SL+K + T A + + D+
Sbjct: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLY 272
Query: 598 FLSNGK--LKCAGSSLFLKRKWGIGYHLSLHRN 628
LS G+ K ++L K G+G H + N
Sbjct: 273 ILSQGQCIFKGVVTNLIPYLK-GLGLHCPTYHN 304
Score = 66.2 bits (160), Expect = 2e-10
Identities = 53/204 (25%), Positives = 96/204 (47%), Gaps = 19/204 (9%)
Query: 1200 CLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP- 1258
C K Y+T C S + FC + E++G++G +GAGKST + ++ G +
Sbjct: 75 CWRKRGYKTLLKCLSGK----------FC--RRELIGIMGPSGAGKSTFMNILAGYRESG 122
Query: 1259 TAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAAL 1318
G +++ G +R S Y Q++ L P LT+ E + + A +K K++
Sbjct: 123 MKGQILVNGRPRELRTFRKMSC----YIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKK 178
Query: 1319 S-ISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQ 1377
++ ++ AL L LS G +++L L ++ NP V+ DEP +G+D Q
Sbjct: 179 ELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 238
Query: 1378 MWQILQATVKNKERGTLLTTHYMS 1401
+ ++++ + R + T H S
Sbjct: 239 VVSLMKSLAQG-GRTIICTIHQPS 261
>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 82.8 bits (203), Expect = 2e-15
Identities = 65/213 (30%), Positives = 105/213 (49%), Gaps = 9/213 (4%)
Query: 421 QITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQ 480
++ I+G +GAGKST +NIL+G S + N + E+ RK + Q +
Sbjct: 96 ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPREL---RTFRKMSCYIMQDDML 152
Query: 481 FDFLTVRENLRVFAKIKGIQPKEVEQE-VKRIIMELDMQSIQDIIAKKLSGGQKRKLTLG 539
LTV E + V A +K + +EV++E V I+ L + S LSGGQ+++L +
Sbjct: 153 LPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIA 212
Query: 540 IAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEADI--LADRKV 597
+ ++ +P V+ DEPT+GLD S +V SL+K + T A + + D+
Sbjct: 213 LELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLY 272
Query: 598 FLSNGK--LKCAGSSLFLKRKWGIGYHLSLHRN 628
LS G+ K ++L K G+G H + N
Sbjct: 273 ILSQGQCIFKGVVTNLIPYLK-GLGLHCPTYHN 304
Score = 66.2 bits (160), Expect = 2e-10
Identities = 53/204 (25%), Positives = 96/204 (47%), Gaps = 19/204 (9%)
Query: 1200 CLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKP- 1258
C K Y+T C S + FC + E++G++G +GAGKST + ++ G +
Sbjct: 75 CWRKRGYKTLLKCLSGK----------FC--RRELIGIMGPSGAGKSTFMNILAGYRESG 122
Query: 1259 TAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAAL 1318
G +++ G +R S Y Q++ L P LT+ E + + A +K K++
Sbjct: 123 MKGQILVNGRPRELRTFRKMSC----YIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKK 178
Query: 1319 S-ISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQ 1377
++ ++ AL L LS G +++L L ++ NP V+ DEP +G+D Q
Sbjct: 179 ELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQ 238
Query: 1378 MWQILQATVKNKERGTLLTTHYMS 1401
+ ++++ + R + T H S
Sbjct: 239 VVSLMKSLAQG-GRTIICTIHQPS 261
>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
Length = 655
Score = 80.9 bits (198), Expect = 9e-15
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 14/218 (6%)
Query: 422 ITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQF 481
+ AILG G GKS+LL++L+ + S + ++ + N G+ Q +
Sbjct: 75 LNAILGPTGGGKSSLLDVLAARK---DPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVM 131
Query: 482 DFLTVRENLRVFAKIK---GIQPKEVEQEVKRIIMELDMQSIQDI-----IAKKLSGGQK 533
LTVRENL+ A ++ + E + + R+I EL + + D + +SGG++
Sbjct: 132 GTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGER 191
Query: 534 RKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE-HKVDRLILFST-QFMDEADI 591
++ ++G+ ++ DP +L LDEPT GLD + + V LLK K R I+FS Q
Sbjct: 192 KRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFK 251
Query: 592 LADRKVFLSNGKLKCAG-SSLFLKRKWGIGYHLSLHRN 628
L D L++G+L G + L GYH + N
Sbjct: 252 LFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNN 289
Score = 55.1 bits (131), Expect = 5e-07
Identities = 57/245 (23%), Positives = 115/245 (46%), Gaps = 22/245 (8%)
Query: 1202 HKEYYETK-KSCFSTRKKKIA---IRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTK 1257
H Y K KS F +K + + N++ +K G + +LG G GKS+ + ++
Sbjct: 40 HNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKD 98
Query: 1258 PT--AGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVK---GLG 1312
P+ +G V++ G+ + ++ GY Q++ + LT++E+L+ AA++ +
Sbjct: 99 PSGLSGDVLINGAPRPANFKCNS-----GYVVQDDVVMGTLTVRENLQFSAALRLATTMT 153
Query: 1313 KEDAALSISRLVEALKLQEQLKAPVKT-----LSEGIKRKLCFVLSILGNPSVVLLDEPF 1367
+ I+R+++ L L + + V T +S G +++ + ++ +PS++ LDEP
Sbjct: 154 NHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPT 213
Query: 1368 TGMDPEGQQQMWQILQATVKNKERGTLLTTHY-MSEAEAVCDRMAMMVSGTLRCIGSIQH 1426
TG+D + +L+ K + R + + H + D + ++ SG L G Q
Sbjct: 214 TGLDSSTANAVLLLLKRMSK-QGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQE 272
Query: 1427 LKNKF 1431
F
Sbjct: 273 ALGYF 277
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 75.1 bits (183), Expect = 5e-13
Identities = 56/227 (24%), Positives = 111/227 (48%), Gaps = 16/227 (7%)
Query: 407 VEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSEITDMEE 466
+ LQG+ ++ +GQ A++G +G GKST++ +L G + ++ + +++
Sbjct: 1050 IPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRL-NVQW 1108
Query: 467 IRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQDIIAK 526
+R ++G Q FD ++ EN+ + + +E+ + K + ++S+ + +
Sbjct: 1109 LRAHLGIVSQEPILFD-CSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYST 1167
Query: 527 K-------LSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDR-- 577
K LSGGQK+++ + A++ P +LLLDE T+ LD S V L + + R
Sbjct: 1168 KVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1227
Query: 578 -LILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHL 623
+I + AD++ V NG++K G+ L + GI + +
Sbjct: 1228 IVIAHRLSTIQNADLI----VVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
Score = 73.2 bits (178), Expect = 2e-12
Identities = 62/217 (28%), Positives = 110/217 (50%), Gaps = 17/217 (7%)
Query: 388 KEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVST 447
K + RNV Y + +V+ L+G+ + GQ A++G++G GKST + ++ L T
Sbjct: 389 KGNLEFRNVHFSYPSRK-EVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPT 447
Query: 448 EGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE 507
EG ++ + I ++ +R+ IG Q F T+ EN+R + + E+E+
Sbjct: 448 EGMVSVDGQDIRTI-NVRFLREIIGVVSQEPVLFA-TTIAENIRYGRE--NVTMDEIEKA 503
Query: 508 VKR-----IIMELDMQSIQDIIAKK---LSGGQKRKLTLGIAILGDPQVLLLDEPTAGLD 559
VK IM+L ++ ++ LSGGQK+++ + A++ +P++LLLDE T+ LD
Sbjct: 504 VKEANAYDFIMKLP-HKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 562
Query: 560 PFSRHRVWSLLKEHKVDR---LILFSTQFMDEADILA 593
S V L + + R +I + AD++A
Sbjct: 563 TESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIA 599
Score = 58.5 bits (140), Expect = 5e-08
Identities = 48/200 (24%), Positives = 97/200 (48%), Gaps = 21/200 (10%)
Query: 1213 FSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASV 1272
+ +RK+ ++ ++ V+ G+ + L+G++G GKST+++++ PT G+V + G +
Sbjct: 401 YPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQ--DI 458
Query: 1273 RQQHDNSLK-FLGYCPQENSLWPKLTMKEHL----------ELYAAVKGLGKEDAALSIS 1321
R + L+ +G QE L+ T+ E++ E+ AVK D + +
Sbjct: 459 RTINVRFLREIIGVVSQEPVLF-ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLP 517
Query: 1322 RLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQI 1381
+ L + + LS G K+++ +++ NP ++LLDE + +D E + +
Sbjct: 518 HKFDTLVGERGAQ-----LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
Query: 1382 LQATVKNKERGTLLTTHYMS 1401
L K R T++ H +S
Sbjct: 573 LDKA--RKGRTTIVIAHRLS 590
Score = 58.2 bits (139), Expect = 6e-08
Identities = 54/223 (24%), Positives = 107/223 (47%), Gaps = 14/223 (6%)
Query: 1213 FSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASV 1272
+ TR ++ +S VKKG+ L L+G +G GKST ++++ P AG V+L G +
Sbjct: 1044 YPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGK--EI 1101
Query: 1273 RQQHDNSLK-FLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAA-----LSISRLVEA 1326
++ + L+ LG QE L+ ++ E++ + + +E+ +I +E+
Sbjct: 1102 KRLNVQWLRAHLGIVSQEPILF-DCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIES 1160
Query: 1327 LKLQEQLKAPVK--TLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQA 1384
L + K K LS G K+++ +++ P ++LLDE + +D E ++ + + L
Sbjct: 1161 LPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD- 1219
Query: 1385 TVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHL 1427
K +E T + + D + + +G ++ G+ Q L
Sbjct: 1220 --KAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL 1260
>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
sapiens]
Length = 651
Score = 73.9 bits (180), Expect = 1e-12
Identities = 60/212 (28%), Positives = 108/212 (50%), Gaps = 12/212 (5%)
Query: 408 EALQGIFFDIYEGQITAILGHNGAGKSTLLNILSG-LSVSTEGSATIYNTQLSEITDMEE 466
+ L+ + + GQI ILG +G+GK+TLL+ +SG L + +Y E+
Sbjct: 67 QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVN--GRALRREQ 124
Query: 467 IRKNIGFCPQFNFQFDFLTVRENLRVFA--KIKGIQPKEVEQEVKRIIMELDMQSIQDII 524
+ + Q + LTVRE L A I+ P +++V+ ++ EL + + D +
Sbjct: 125 FQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRL 184
Query: 525 AKK-----LSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE-HKVDRL 578
+S G++R++++ +L DP+V+L DEPT GLD + +++ LL E + +R+
Sbjct: 185 IGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRI 244
Query: 579 ILFST-QFMDEADILADRKVFLSNGKLKCAGS 609
++ + Q E L D+ LS G+L G+
Sbjct: 245 VVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/271 (26%), Positives = 125/271 (46%), Gaps = 30/271 (11%)
Query: 1174 VQAERVQAANALTAPNLEEEPVITASCLHKEYYETKK--------SCFSTRKKKIAIRNV 1225
+Q R ++ AP EP + LH Y + + SC ++I +++V
Sbjct: 15 LQVNRGSQSSLEGAPATAPEPH-SLGILHASYSVSHRVRPWWDITSCRQQWTRQI-LKDV 72
Query: 1226 SFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTA---GVVVLQGSRASVRQQHDNSLKF 1282
S V+ G+++ +LG +G+GK+T + ++G G V + G RA R+Q +
Sbjct: 73 SLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNG-RALRREQFQDCFS- 130
Query: 1283 LGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTL-- 1340
Y Q ++L LT++E L Y A+ + + + S + VEA+ + L L
Sbjct: 131 --YVLQSDTLLSSLTVRETLH-YTALLAIRRGNPG-SFQKKVEAVMAELSLSHVADRLIG 186
Query: 1341 -------SEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGT 1393
S G +R++ +L +P V+L DEP TG+D Q+ +L + + R
Sbjct: 187 NYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQI-VVLLVELARRNRIV 245
Query: 1394 LLTTHY-MSEAEAVCDRMAMMVSGTLRCIGS 1423
+LT H SE + D++A++ G L G+
Sbjct: 246 VLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,693,125
Number of Sequences: 37866
Number of extensions: 2387495
Number of successful extensions: 8098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 7455
Number of HSP's gapped (non-prelim): 338
length of query: 1543
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1428
effective length of database: 13,892,928
effective search space: 19839101184
effective search space used: 19839101184
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.