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Search of human proteins with 15193292
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15193292 NLR family, pyrin domain containing 12 isoform 1
[Homo sapiens]
(287 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 587 e-168
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 406 e-113
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 219 2e-57
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 219 2e-57
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 218 4e-57
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 202 3e-52
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 202 3e-52
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 202 3e-52
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 202 3e-52
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 202 3e-52
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 202 3e-52
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 202 3e-52
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 202 3e-52
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 201 5e-52
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 192 4e-49
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 188 5e-48
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 186 2e-47
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 183 2e-46
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 171 7e-43
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 166 3e-41
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 162 2e-40
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 162 3e-40
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 151 7e-37
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 151 7e-37
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 151 7e-37
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 144 7e-35
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 144 7e-35
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 135 5e-32
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 135 5e-32
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 135 5e-32
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 587 bits (1514), Expect = e-168
Identities = 287/287 (100%), Positives = 287/287 (100%)
Query: 1 MSQAWWHTSVSPATQEAKAGGLLQPRRQRLWLKRCRISSSACEDLSAALIANKNLTRMDL 60
MSQAWWHTSVSPATQEAKAGGLLQPRRQRLWLKRCRISSSACEDLSAALIANKNLTRMDL
Sbjct: 1 MSQAWWHTSVSPATQEAKAGGLLQPRRQRLWLKRCRISSSACEDLSAALIANKNLTRMDL 60
Query: 61 SGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGN 120
SGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGN
Sbjct: 61 SGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGN 120
Query: 121 ALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELG 180
ALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELG
Sbjct: 121 ALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELG 180
Query: 181 DLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTG 240
DLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTG
Sbjct: 181 DLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTG 240
Query: 241 VRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 287
VRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC
Sbjct: 241 VRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 287
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 406 bits (1044), Expect = e-113
Identities = 223/326 (68%), Positives = 236/326 (72%), Gaps = 59/326 (18%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GL P + Q L LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR
Sbjct: 736 GLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 795
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV
Sbjct: 796 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 855
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL
Sbjct: 856 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 915
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
QTLRL C L + ACE L L N L +L L+ N LGD G+ LL + L HP C+L+ L
Sbjct: 916 QTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKL 975
Query: 259 WL--------------FGMDLN-----------------------KMTH----------- 270
WL F + +N +++H
Sbjct: 976 WLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035
Query: 271 ---------SRLAALRVTKPYLDIGC 287
SRLAALRVTKPYLDIGC
Sbjct: 1036 GMDLNKMTHSRLAALRVTKPYLDIGC 1061
Score = 228 bits (580), Expect = 6e-60
Identities = 111/218 (50%), Positives = 152/218 (69%)
Query: 43 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 102
E L+AAL N NL + L N +G G+ LLC+GLRHP C+LQ ++L++C++ S AC+++
Sbjct: 703 EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
Query: 103 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 162
++ L N +L +DL+GN + G+ LLC+GLRHP CRL+ + L+ C+L + AC E+AS
Sbjct: 763 SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASV 822
Query: 163 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGI 222
L N L ELDL+ N L DLG+ LLC+GLRHP C+L+TL L C LTA AC+ L TL +
Sbjct: 823 LGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSV 882
Query: 223 NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
NQ+L +L L+ N LGD GV LLC+ L HP CKL+ L L
Sbjct: 883 NQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 920
Score = 106 bits (264), Expect = 3e-23
Identities = 57/133 (42%), Positives = 79/133 (59%)
Query: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210
L A + LA+ L N +L EL L N LG GV LLC+GLRHP CKLQ LRL C +++
Sbjct: 697 LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
Query: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270
ACE+L L N+ LT + L+ N +G G+ LLC+ L HP C+L+++ L L
Sbjct: 757 SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
Query: 271 SRLAALRVTKPYL 283
+A++ T P+L
Sbjct: 817 QEMASVLGTNPHL 829
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 219 bits (558), Expect = 2e-57
Identities = 112/234 (47%), Positives = 149/234 (63%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L ++SS C L + L +++LT +DLS N +G PGM +LCE L+HP C ++ + L +
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C +++ VL +N LVELDL+ NAL D G+RLLC GL+H +C L+ LWL C L
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 839
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
T+A C +LAS LS + SL L + N LGD GV +LCE ++P C LQ L L + GLT+
Sbjct: 840 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 899
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 265
C L L NQ LT LYL N LGD G++LLC+ L HP CKL+VL L +L
Sbjct: 900 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 953
Score = 209 bits (533), Expect = 2e-54
Identities = 116/258 (44%), Positives = 151/258 (58%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+RLWL RC +S C D+S L +N+ L +DLS N +G G+ LLC GL+H C L+ +
Sbjct: 773 RRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKL 832
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L C L S CQ++ASVL T+ L L + NAL D G+ +LC+ ++P C L+ L L
Sbjct: 833 WLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLV 892
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
LT+ C L+S LS NQ+L L L N LGD G+ LLCEGL HP CKLQ L LD+C
Sbjct: 893 NSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCN 952
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
LT+ C +L L +Q+L L L NN LGD GV + C+ L C L+ L L M N
Sbjct: 953 LTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNY 1012
Query: 268 MTHSRLAALRVTKPYLDI 285
T S L L+ KP L +
Sbjct: 1013 ETKSALETLQEEKPELTV 1030
Score = 160 bits (406), Expect = 9e-40
Identities = 85/190 (44%), Positives = 118/190 (62%)
Query: 94 LESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTA 153
L S C+ + SVL T+ L ELDL+ N+L D G+R+LC+ L+HP C +R LWL C L+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 154 AACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKAC 213
C +++ LS NQ L ELDLS N LGD G+ LLC GL+H C L+ L L SC LT+ C
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
Query: 214 ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRL 273
++L L + +LT LY+ NALGD+GV +LC++ +P C L+ L L L + S L
Sbjct: 845 QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
Query: 274 AALRVTKPYL 283
+++ T L
Sbjct: 905 SSVLSTNQNL 914
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 219 bits (558), Expect = 2e-57
Identities = 112/234 (47%), Positives = 149/234 (63%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L ++SS C L + L +++LT +DLS N +G PGM +LCE L+HP C ++ + L +
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C +++ VL +N LVELDL+ NAL D G+RLLC GL+H +C L+ LWL C L
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 839
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
T+A C +LAS LS + SL L + N LGD GV +LCE ++P C LQ L L + GLT+
Sbjct: 840 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 899
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 265
C L L NQ LT LYL N LGD G++LLC+ L HP CKL+VL L +L
Sbjct: 900 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 953
Score = 209 bits (533), Expect = 2e-54
Identities = 116/258 (44%), Positives = 151/258 (58%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+RLWL RC +S C D+S L +N+ L +DLS N +G G+ LLC GL+H C L+ +
Sbjct: 773 RRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKL 832
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L C L S CQ++ASVL T+ L L + NAL D G+ +LC+ ++P C L+ L L
Sbjct: 833 WLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLV 892
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
LT+ C L+S LS NQ+L L L N LGD G+ LLCEGL HP CKLQ L LD+C
Sbjct: 893 NSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCN 952
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
LT+ C +L L +Q+L L L NN LGD GV + C+ L C L+ L L M N
Sbjct: 953 LTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNY 1012
Query: 268 MTHSRLAALRVTKPYLDI 285
T S L L+ KP L +
Sbjct: 1013 ETKSALETLQEEKPELTV 1030
Score = 160 bits (406), Expect = 9e-40
Identities = 85/190 (44%), Positives = 118/190 (62%)
Query: 94 LESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTA 153
L S C+ + SVL T+ L ELDL+ N+L D G+R+LC+ L+HP C +R LWL C L+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 154 AACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKAC 213
C +++ LS NQ L ELDLS N LGD G+ LLC GL+H C L+ L L SC LT+ C
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
Query: 214 ENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRL 273
++L L + +LT LY+ NALGD+GV +LC++ +P C L+ L L L + S L
Sbjct: 845 QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
Query: 274 AALRVTKPYL 283
+++ T L
Sbjct: 905 SSVLSTNQNL 914
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 218 bits (556), Expect = 4e-57
Identities = 117/254 (46%), Positives = 154/254 (60%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L ++SS C L + L +++LT +DLS N +G PGM +LCE L+HP C ++ + L +
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C +++ VL +N LVELDL+ NAL D G+RLLC GL+H +C L+ LWL L
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 839
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
T+ C L+S LS NQ+L L L N LGD G+ LLCEGL HP CKLQ L LD+C LT+
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHS 271
C +L L +Q+L L L NN LGD GV + C+ L C L+ L L M N T S
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 272 RLAALRVTKPYLDI 285
L L+ KP L +
Sbjct: 960 ALETLQEEKPELTV 973
Score = 161 bits (407), Expect = 7e-40
Identities = 82/176 (46%), Positives = 113/176 (64%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+RLWL RC +S C D+S L +N+ L +DLS N +G G+ LLC GL+H C L+ +
Sbjct: 773 RRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKL 832
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L L S C ++SVL TN +L L L GN L D G++LLC+GL HP C+L+ L L
Sbjct: 833 WLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELD 892
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203
C LT+ C +L++ L+ +QSLR+L L N+LGDLGV++ CE L+ +C LQ L L
Sbjct: 893 NCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 202 bits (514), Expect = 3e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
Query: 259 WLFGMDLNKMTHSRLAA 275
WL D++ + S LAA
Sbjct: 376 WLADCDVSDSSCSSLAA 392
Score = 199 bits (505), Expect = 3e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
Score = 187 bits (474), Expect = 1e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Score = 180 bits (456), Expect = 1e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
Query: 268 MTHSRLAALRVTKPYLDI 285
RL AL KP L +
Sbjct: 442 EMEDRLQALEKDKPSLRV 459
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
Query: 199 QTLRL 203
+ L L
Sbjct: 430 EQLVL 434
Score = 142 bits (358), Expect = 3e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 106 bits (264), Expect = 3e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 269 THSRLAALRVTKP 281
+ LA++ KP
Sbjct: 158 SCEPLASVLRAKP 170
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 202 bits (514), Expect = 3e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
Query: 259 WLFGMDLNKMTHSRLAA 275
WL D++ + S LAA
Sbjct: 376 WLADCDVSDSSCSSLAA 392
Score = 199 bits (505), Expect = 3e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
Score = 187 bits (474), Expect = 1e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Score = 180 bits (456), Expect = 1e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
Query: 268 MTHSRLAALRVTKPYLDI 285
RL AL KP L +
Sbjct: 442 EMEDRLQALEKDKPSLRV 459
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
Query: 199 QTLRL 203
+ L L
Sbjct: 430 EQLVL 434
Score = 142 bits (358), Expect = 3e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 106 bits (264), Expect = 3e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 269 THSRLAALRVTKP 281
+ LA++ KP
Sbjct: 158 SCEPLASVLRAKP 170
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 202 bits (514), Expect = 3e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
Query: 259 WLFGMDLNKMTHSRLAA 275
WL D++ + S LAA
Sbjct: 376 WLADCDVSDSSCSSLAA 392
Score = 199 bits (505), Expect = 3e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
Score = 187 bits (474), Expect = 1e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Score = 180 bits (456), Expect = 1e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
Query: 268 MTHSRLAALRVTKPYLDI 285
RL AL KP L +
Sbjct: 442 EMEDRLQALEKDKPSLRV 459
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
Query: 199 QTLRL 203
+ L L
Sbjct: 430 EQLVL 434
Score = 142 bits (358), Expect = 3e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 106 bits (264), Expect = 3e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 269 THSRLAALRVTKP 281
+ LA++ KP
Sbjct: 158 SCEPLASVLRAKP 170
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 202 bits (514), Expect = 3e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
Query: 259 WLFGMDLNKMTHSRLAA 275
WL D++ + S LAA
Sbjct: 376 WLADCDVSDSSCSSLAA 392
Score = 199 bits (505), Expect = 3e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
Score = 187 bits (474), Expect = 1e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Score = 180 bits (456), Expect = 1e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
Query: 268 MTHSRLAALRVTKPYLDI 285
RL AL KP L +
Sbjct: 442 EMEDRLQALEKDKPSLRV 459
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
Query: 199 QTLRL 203
+ L L
Sbjct: 430 EQLVL 434
Score = 142 bits (358), Expect = 3e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 106 bits (264), Expect = 3e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 269 THSRLAALRVTKP 281
+ LA++ KP
Sbjct: 158 SCEPLASVLRAKP 170
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 202 bits (514), Expect = 3e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
Query: 259 WLFGMDLNKMTHSRLAA 275
WL D++ + S LAA
Sbjct: 376 WLADCDVSDSSCSSLAA 392
Score = 199 bits (505), Expect = 3e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
Score = 187 bits (474), Expect = 1e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Score = 180 bits (456), Expect = 1e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
Query: 268 MTHSRLAALRVTKPYLDI 285
RL AL KP L +
Sbjct: 442 EMEDRLQALEKDKPSLRV 459
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
Query: 199 QTLRL 203
+ L L
Sbjct: 430 EQLVL 434
Score = 142 bits (358), Expect = 3e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 106 bits (264), Expect = 3e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 269 THSRLAALRVTKP 281
+ LA++ KP
Sbjct: 158 SCEPLASVLRAKP 170
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 202 bits (514), Expect = 3e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
Query: 259 WLFGMDLNKMTHSRLAA 275
WL D++ + S LAA
Sbjct: 376 WLADCDVSDSSCSSLAA 392
Score = 199 bits (505), Expect = 3e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
Score = 187 bits (474), Expect = 1e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Score = 180 bits (456), Expect = 1e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
Query: 268 MTHSRLAALRVTKPYLDI 285
RL AL KP L +
Sbjct: 442 EMEDRLQALEKDKPSLRV 459
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
Query: 199 QTLRL 203
+ L L
Sbjct: 430 EQLVL 434
Score = 142 bits (358), Expect = 3e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 106 bits (264), Expect = 3e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 269 THSRLAALRVTKP 281
+ LA++ KP
Sbjct: 158 SCEPLASVLRAKP 170
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 202 bits (514), Expect = 3e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
Query: 259 WLFGMDLNKMTHSRLAA 275
WL D++ + S LAA
Sbjct: 376 WLADCDVSDSSCSSLAA 392
Score = 199 bits (505), Expect = 3e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
Score = 187 bits (474), Expect = 1e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Score = 180 bits (456), Expect = 1e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
Query: 268 MTHSRLAALRVTKPYLDI 285
RL AL KP L +
Sbjct: 442 EMEDRLQALEKDKPSLRV 459
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
Query: 199 QTLRL 203
+ L L
Sbjct: 430 EQLVL 434
Score = 142 bits (358), Expect = 3e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 106 bits (264), Expect = 3e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 269 THSRLAALRVTKP 281
+ LA++ KP
Sbjct: 158 SCEPLASVLRAKP 170
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 202 bits (514), Expect = 3e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
Query: 259 WLFGMDLNKMTHSRLAA 275
WL D++ + S LAA
Sbjct: 376 WLADCDVSDSSCSSLAA 392
Score = 199 bits (505), Expect = 3e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
Score = 187 bits (474), Expect = 1e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
Score = 180 bits (456), Expect = 1e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
Query: 268 MTHSRLAALRVTKPYLDI 285
RL AL KP L +
Sbjct: 442 EMEDRLQALEKDKPSLRV 459
Score = 157 bits (397), Expect = 1e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
Query: 199 QTLRL 203
+ L L
Sbjct: 430 EQLVL 434
Score = 142 bits (358), Expect = 3e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
Query: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
Query: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 106 bits (264), Expect = 3e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 269 THSRLAALRVTKP 281
+ LA++ KP
Sbjct: 158 SCEPLASVLRAKP 170
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 201 bits (512), Expect = 5e-52
Identities = 113/254 (44%), Positives = 147/254 (57%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L RC +S C D+S L +N+ L +DLS N +G G+ LLC GL+H C L+ + L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
C L S CQ++ASVL T+ L L + NAL D G+ +LC+ ++P C L+ L L L
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
T+ C L+S LS NQ+L L L N LGD G+ LLCEGL HP CKLQ L LD+C LT+
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHS 271
C +L L +Q+L L L NN LGD GV + C+ L C L+ L L M N T S
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 272 RLAALRVTKPYLDI 285
L L+ KP L +
Sbjct: 960 ALETLQEEKPELTV 973
Score = 159 bits (401), Expect = 3e-39
Identities = 78/176 (44%), Positives = 116/176 (65%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
++LWL C ++S+ C+DL++ L + +LTR+ + N +G G+ +LCE ++PQC LQ +
Sbjct: 773 KKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKL 832
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L L S C ++SVL TN +L L L GN L D G++LLC+GL HP C+L+ L L
Sbjct: 833 GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELD 892
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203
C LT+ C +L++ L+ +QSLR+L L N+LGDLGV++ CE L+ +C LQ L L
Sbjct: 893 NCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 192 bits (487), Expect = 4e-49
Identities = 108/258 (41%), Positives = 154/258 (59%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+RL L+ C ++ + CE LS ALI+NK LT + L+ N +G G+ L+ + L+H QC L+ +
Sbjct: 818 ERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSL 877
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
LR+C S + + +++ L N L LDL N L+D G++LLC RHP C L+ L L
Sbjct: 878 VLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELM 937
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C LT A C +LAS + N +LR LDL N+L D GV +LC+ LR+P C +Q L L+ CG
Sbjct: 938 GCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCG 997
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
LT+ C++L L N+ L + LT N LG G+ L K L P CKL+VL L ++
Sbjct: 998 LTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDE 1057
Query: 268 MTHSRLAALRVTKPYLDI 285
L A+ V+ P+L I
Sbjct: 1058 EAQKLLEAVGVSNPHLII 1075
Score = 178 bits (452), Expect = 4e-45
Identities = 100/242 (41%), Positives = 143/242 (59%)
Query: 42 CEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQE 101
C+D+S +LI NKNL +DL G+ +G G+ LCE L+HP+C+LQ ++L C L C
Sbjct: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
Query: 102 MASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAS 161
+++ L + L+ L+L+ N L D G++LLC+ LRHP C L L L+ C LT A C+ L+
Sbjct: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
Query: 162 TLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLG 221
L N+ L L L+ N LGD GV L+ + L+H C L++L L C T+ + E L +L
Sbjct: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
Query: 222 INQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 281
N++LT L L +N L D GV+LLC HP C L+ L L G L LA++ + P
Sbjct: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
Query: 282 YL 283
L
Sbjct: 958 NL 959
Score = 169 bits (429), Expect = 2e-42
Identities = 94/218 (43%), Positives = 132/218 (60%), Gaps = 1/218 (0%)
Query: 43 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 102
+DL + L N++L +DL + + M +L LRHP C+LQ + L+ G CQ++
Sbjct: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDG-CQDI 721
Query: 103 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 162
++ L N +L+ LDL G+ + D G++ LC+ L+HP C+L+TL L+ C LT C +++
Sbjct: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
Query: 163 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGI 222
L +QSL L+LS N L D GV LLCE LRHP C L+ L L+SCGLT CE L L
Sbjct: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
Query: 223 NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
N+ LT L L +N LGD GV+L+ L H C L+ L L
Sbjct: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVL 879
Score = 167 bits (424), Expect = 8e-42
Identities = 92/233 (39%), Positives = 134/233 (57%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q L L+ C ++ C ++S ALI +++L ++LS N + G+ LLCE LRHP+C L+ +
Sbjct: 761 QTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERL 820
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L C L C+ ++ L +N L L L N L D G++L+ L+H C L++L L+
Sbjct: 821 SLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLR 880
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C T+ + + L+++L N+SL LDL N L D GV LLC+ RHP+C LQ L L C
Sbjct: 881 RCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCV 940
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
LT C +L + N L L L NN L D GV++LC L +P C ++ L L
Sbjct: 941 LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGL 993
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 188 bits (477), Expect = 5e-48
Identities = 107/258 (41%), Positives = 149/258 (57%), Gaps = 1/258 (0%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L C +S CE L+ L NK LT +++S N + G+ LLCE L P L +
Sbjct: 726 KELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYL 784
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L C L C+ ++ +L N + LDL+ N L+D GL+ LC+ L+HP C L +L L
Sbjct: 785 MLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLV 844
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +TAA C++LAS L NQ+L+ L + NE+GD+GV LLC L H C+L+ L L+ CG
Sbjct: 845 KCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECG 904
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
LT+ C++L L ++TL L LT N L TGV +LC+ L HP C L+VL L D ++
Sbjct: 905 LTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDE 964
Query: 268 MTHSRLAALRVTKPYLDI 285
T + L A P L I
Sbjct: 965 ETQALLTAEEERNPNLTI 982
Score = 106 bits (265), Expect = 2e-23
Identities = 78/246 (31%), Positives = 115/246 (46%), Gaps = 5/246 (2%)
Query: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
+ + L + +L + + + + + C LRHP CRLQ + + SG +
Sbjct: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSF-SGQSVLLFE 688
Query: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
VL P L L T L +R LC L +P ++ L L C L+ C+ LA L+
Sbjct: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
Query: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQ 224
N+ L L++S N+L D GV LLCE L P L L L C L+ + CE + L N+
Sbjct: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
Query: 225 TLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTK---P 281
++ L L+ N L D G++ LC+ L HP C L L L + LA+ ++
Sbjct: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
Query: 282 YLDIGC 287
L IGC
Sbjct: 868 ILQIGC 873
Score = 65.1 bits (157), Expect = 7e-11
Identities = 31/91 (34%), Positives = 55/91 (60%)
Query: 26 RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQ 85
R + L L+ C ++S+ C+DL++ L +K L +++L+ N + G+++LCE LRHP+C LQ
Sbjct: 894 RLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQ 953
Query: 86 MIQLRKCQLESGACQEMASVLGTNPHLVELD 116
++ LRK + + + NP+L D
Sbjct: 954 VLGLRKTDFDEETQALLTAEEERNPNLTITD 984
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 186 bits (473), Expect = 2e-47
Identities = 103/258 (39%), Positives = 144/258 (55%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L +C ISS CED+++ L N L + L N + GM LLCE L+H C L+ +
Sbjct: 717 EELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERL 776
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L C L S +C ++ VL + L LDL NALED G+ LC L+HP C +R LWL
Sbjct: 777 MLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLM 836
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C LT+ +C ++A+ L N L+ L L NE+GD GV LC L+HP CKL+ L L +C
Sbjct: 837 GCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCP 896
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
+T C+++ L +TL L L AL V +LC+ LSHP C L++L L ++
Sbjct: 897 ITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDE 956
Query: 268 MTHSRLAALRVTKPYLDI 285
T L ++ P+L I
Sbjct: 957 ETQKILMSVEEKIPHLTI 974
Score = 169 bits (429), Expect = 2e-42
Identities = 89/217 (41%), Positives = 124/217 (57%)
Query: 44 DLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMA 103
+L A++ N +L + L G + + LCE L+HP C+++ + L KC + S C+++A
Sbjct: 676 ELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIA 735
Query: 104 SVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTL 163
SVL N L L L N L D G+ LLC+ L+H C L L L C LT+ +CD ++ L
Sbjct: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795
Query: 164 SVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGIN 223
++SL LDL N L D GV LC L+HP C ++ L L C LT+ +C+++ L N
Sbjct: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855
Query: 224 QTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L L L +N +GDTGVR LC L HP CKL L L
Sbjct: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892
Score = 157 bits (397), Expect = 1e-38
Identities = 84/235 (35%), Positives = 130/235 (55%), Gaps = 2/235 (0%)
Query: 44 DLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMA 103
+L + I NKN +D+ + P + +LC+ L P C+L+ + G E+
Sbjct: 621 ELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF--GHDSELF 678
Query: 104 SVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTL 163
+ NPHL L L G +L +R LC+ L+HP+C++ L L C +++ C+++AS L
Sbjct: 679 KAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVL 738
Query: 164 SVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGIN 223
+ N L+ L L N L D G+ LLCE L+H C L+ L L C LT+ +C+++ L +
Sbjct: 739 ACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCS 798
Query: 224 QTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRV 278
++L+ L L +NAL D GV LC L HPGC +R LWL G L + +AA+ +
Sbjct: 799 KSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 183 bits (464), Expect = 2e-46
Identities = 97/254 (38%), Positives = 145/254 (57%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q+L L+ C I+++ C+ L++AL++N++LT + LS N +G G+ LLC +R P C LQ +
Sbjct: 926 QKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRL 985
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L +C L++ C +A L N L L L+ N +ED G++LLC+ +R P C L+ L L
Sbjct: 986 MLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELV 1045
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C LTAA C+ L+ +S ++ L+ LDL+ N LGD GV LCEGL+ L L L +CG
Sbjct: 1046 KCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACG 1105
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
LT+ CE L L N+ LT L L N G+ LC + P L+++ L+
Sbjct: 1106 LTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPV 1165
Query: 268 MTHSRLAALRVTKP 281
L +++ KP
Sbjct: 1166 QIRKLLEEVQLLKP 1179
Score = 154 bits (389), Expect = 9e-38
Identities = 93/233 (39%), Positives = 126/233 (54%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L C ++ + +S L + +L + L+GN V G+M L + LR QC LQ +
Sbjct: 869 ESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKL 928
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L C + + CQ +AS L +N L L L+ N+L + G+ LLC+ +R P C L+ L L
Sbjct: 929 ILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLN 988
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C L A C LA L N L L LS+N + D GV LLCE +R P+C LQ L L C
Sbjct: 989 QCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCH 1048
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
LTA CE+L + ++ L L LT+NALGD GV LC+ L L L L
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGL 1101
Score = 150 bits (380), Expect = 1e-36
Identities = 83/231 (35%), Positives = 132/231 (57%), Gaps = 1/231 (0%)
Query: 30 LWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQL 89
LW++ + ED + L + +L ++DL + + M LC LRHP C++Q +
Sbjct: 758 LWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMF 817
Query: 90 RKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKIC 149
R Q+ G Q + ++ N +L L+L G L++ +R+ C+ L+HP C L +L L C
Sbjct: 818 RNAQITPGV-QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCC 876
Query: 150 RLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLT 209
LT A +++ L+ + SL+ L L+ N++ D GV+ L + LR C LQ L L+ CG+T
Sbjct: 877 GLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGIT 936
Query: 210 AKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
A C++L L N++LT L L+NN+LG+ GV LLC+ + P C L+ L L
Sbjct: 937 ATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLML 987
Score = 148 bits (374), Expect = 5e-36
Identities = 88/233 (37%), Positives = 125/233 (53%), Gaps = 1/233 (0%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q L + +I+ + L ++AN+NL ++L G + + + CE L+HP+C L+ +
Sbjct: 813 QTLMFRNAQITPGV-QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
+L C L +++ +L T+P L L L GN + D G+ L LR C L+ L L+
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
C +TA C LAS L N+SL L LS N LG+ GV LLC +R P C LQ L L+ C
Sbjct: 932 DCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCH 991
Query: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
L C L L N LT L L+ N + D GV+LLC+ + P C L+ L L
Sbjct: 992 LDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
Score = 102 bits (255), Expect = 3e-22
Identities = 61/179 (34%), Positives = 93/179 (51%), Gaps = 1/179 (0%)
Query: 82 CRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 141
C + + +R L ++ S+LGT+PHL +LDL + L + ++ LC LRHP C++
Sbjct: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
Query: 142 RTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTL 201
+TL + ++T L + N++LR L+L L + V + CE L+HP C L++L
Sbjct: 813 QTLMFRNAQITPGV-QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
Query: 202 RLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
RLD CGLT + L + +L L L N + D GV L L C L+ L L
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLIL 930
Score = 73.9 bits (180), Expect = 1e-13
Identities = 45/145 (31%), Positives = 71/145 (48%), Gaps = 1/145 (0%)
Query: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
C + LW++ L ++ S L + LR+LDL + L + + LC LRHPTCK+
Sbjct: 753 CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812
Query: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
QTL + +T ++L+ + N+ L L L L + VR+ C+ L HP C L L
Sbjct: 813 QTLMFRNAQITP-GVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871
Query: 259 WLFGMDLNKMTHSRLAALRVTKPYL 283
L L + +++ + T P L
Sbjct: 872 RLDCCGLTHACYLKISQILTTSPSL 896
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 171 bits (433), Expect = 7e-43
Identities = 94/197 (47%), Positives = 118/197 (59%)
Query: 89 LRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKI 148
L +C L C +++ VL +N LVELDL+ NAL D G+RLLC GL+H +C L+ LWL
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
LT+ C L+S LS NQ+L L L N LGD G+ LLCEGL HP CKLQ L LD+C L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
T+ C +L L +Q+L L L NN LGD GV + C+ L C L+ L L M N
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYE 899
Query: 269 THSRLAALRVTKPYLDI 285
T S L L+ KP L +
Sbjct: 900 TKSALETLQEEKPELTV 916
Score = 153 bits (386), Expect = 2e-37
Identities = 79/172 (45%), Positives = 109/172 (63%)
Query: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
L RC +S C D+S L +N+ L +DLS N +G G+ LLC GL+H C L+ + L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
L S C ++SVL TN +L L L GN L D G++LLC+GL HP C+L+ L L C L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203
T+ C +L++ L+ +QSLR+L L N+LGDLGV++ CE L+ +C LQ L L
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
Score = 99.4 bits (246), Expect = 3e-21
Identities = 48/119 (40%), Positives = 74/119 (62%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
++LWL ++S C LS+ L N+NLT + L GN +G G+ LLCEGL HP C+LQ++
Sbjct: 773 KKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVL 832
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWL 146
+L C L S C +++++L ++ L +L L N L DLG+ + C+ L+ C L+ L L
Sbjct: 833 ELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 166 bits (419), Expect = 3e-41
Identities = 90/229 (39%), Positives = 138/229 (60%), Gaps = 1/229 (0%)
Query: 30 LWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQL 89
L L++C +S+++C+DL+ L + +++TR+ L N + G+ LLC L HP+C L+ ++L
Sbjct: 815 LCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLEL 874
Query: 90 RKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKIC 149
CQL + AC+ ++ L N L L+L+ N+L D G++ LC+ L P L++L L C
Sbjct: 875 WFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGC 934
Query: 150 RLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLT 209
T C ELA+ LS N +++ LDL N+L D GV LLCE L+ P L TL L C LT
Sbjct: 935 SFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLT 993
Query: 210 AKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
C++L+ L +++L +L L N L GV++LCK L C+L+ L
Sbjct: 994 TACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
Score = 151 bits (381), Expect = 7e-37
Identities = 88/224 (39%), Positives = 117/224 (52%), Gaps = 10/224 (4%)
Query: 34 RCRISSSAC---------EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRL 84
RC++ C +DL AL N LT ++ S N +G + L+ + LRH C L
Sbjct: 754 RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNL 812
Query: 85 QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTL 144
+ + L KC L + +CQ++A L + H+ L L N L+D G++LLC L HP C L L
Sbjct: 813 KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
Query: 145 WLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLD 204
L C+L A AC L+ L N+SL L+LS N L D GV LCE L P LQ+L L
Sbjct: 873 ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932
Query: 205 SCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRL 248
C T + C L L N + L L N L D GV+LLC+ L
Sbjct: 933 GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL 976
Score = 133 bits (334), Expect = 2e-31
Identities = 82/234 (35%), Positives = 124/234 (52%), Gaps = 2/234 (0%)
Query: 41 ACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQ 100
A + + L+ N+NL +DLS + + + LC L++P+C++Q + + E Q
Sbjct: 714 AWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPE-WVLQ 772
Query: 101 EMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELA 160
++ L N L L+ + N L + + L+ + LRH C L+ L L+ C L+AA+C +LA
Sbjct: 773 DLIIALQGNSKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLA 831
Query: 161 STLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTL 220
L+ Q + L L N L D G+ LLC L HP C L+ L L C L A AC++L L
Sbjct: 832 LFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDAL 891
Query: 221 GINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLA 274
N++LT L L+ N+L D GV+ LC+ L P L+ L L G + LA
Sbjct: 892 LQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELA 945
Score = 126 bits (316), Expect = 3e-29
Identities = 73/174 (41%), Positives = 103/174 (59%), Gaps = 1/174 (0%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+RL L C++++ AC+ LS AL+ N++LT ++LS N + G+ LCE L P LQ +
Sbjct: 870 ERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSL 929
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L C C E+A+ L N ++ LDL N L+D G++LLC+ L+ P L TL L
Sbjct: 930 NLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLA 988
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTL 201
C LT A C L S LS ++SL L+L NEL GV +LC+ L+ TC+LQ L
Sbjct: 989 KCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
Score = 95.9 bits (237), Expect = 4e-20
Identities = 62/178 (34%), Positives = 94/178 (52%), Gaps = 2/178 (1%)
Query: 84 LQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRT 143
L++++ K A + S L TN +L ELDL+ + L ++ LC L++P C+++
Sbjct: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
Query: 144 LWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203
L K +L L N L L+ S N+LG + V L+ + LRH C L+ L L
Sbjct: 760 LTCKSV-TPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCL 817
Query: 204 DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
+ C L+A +C++L L Q +T L L N L D G++LLC L+HP C L L L+
Sbjct: 818 EKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELW 875
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 162 bits (411), Expect = 2e-40
Identities = 92/254 (36%), Positives = 137/254 (53%)
Query: 30 LWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQL 89
L L +C + +S CE++++ LI+ +L ++ LS N + GM +LC+ L HP C L + L
Sbjct: 723 LSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVL 782
Query: 90 RKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKIC 149
C L C + VL +P L +LDL N L++ G+ + L P C+L L L C
Sbjct: 783 VFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGC 842
Query: 150 RLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLT 209
++ C +A ++ N+ LR L++ N++ D G+ LLC GLRHP C L + L+ C LT
Sbjct: 843 FFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLT 902
Query: 210 AKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMT 269
+ C +L L N+TL L L N LG+ GV L + L P C L+V+ L LN T
Sbjct: 903 SACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQT 962
Query: 270 HSRLAALRVTKPYL 283
L ++ KP L
Sbjct: 963 QQLLMTVKERKPSL 976
Score = 145 bits (365), Expect = 5e-35
Identities = 83/247 (33%), Positives = 128/247 (51%)
Query: 38 SSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESG 97
++S EDL AL N++LT + ++ + LL + L P C++ + L KC L +
Sbjct: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
Query: 98 ACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACD 157
C+E+AS+L + L +L L+ N L G+ +LC L HP C L +L L C LT C
Sbjct: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
Query: 158 ELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLY 217
L L + +LR+LDL +N L + GVL + L PTC+L+ L L C ++ C+ +
Sbjct: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
Query: 218 FTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALR 277
+ N+ L L + +N + D G++LLC L HP C L + L L LA++
Sbjct: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
Query: 278 VTKPYLD 284
T L+
Sbjct: 914 TTNKTLE 920
Score = 85.9 bits (211), Expect = 4e-17
Identities = 55/159 (34%), Positives = 78/159 (49%), Gaps = 2/159 (1%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
+ L L C SS C+ ++ + N+ L +++ N + GM LLC GLRHP C L I
Sbjct: 835 EELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNI 894
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L +C L S C+ +ASVL TN L L+L N L + G+ L + L P C L+ + L
Sbjct: 895 GLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954
Query: 148 ICRLTAAACDELASTLSVNQSLRELD--LSLNELGDLGV 184
+ L L + SL L SL E ++GV
Sbjct: 955 LTGLNTQTQQLLMTVKERKPSLIFLSETWSLKEGREIGV 993
Score = 84.3 bits (207), Expect = 1e-16
Identities = 60/184 (32%), Positives = 88/184 (47%), Gaps = 1/184 (0%)
Query: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
+E+ S+ T L EL + N L + R+L + L H C+LRTL L TA+ ++L
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDL 681
Query: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
L+ N+SL L ++ + LL + L PTC++ L L C L A CE +
Sbjct: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
Query: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 279
L +L L L++N L G+ +LC L HP C L L L L + S L + +
Sbjct: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
Query: 280 KPYL 283
P L
Sbjct: 802 SPTL 805
Score = 56.6 bits (135), Expect = 2e-08
Identities = 53/184 (28%), Positives = 85/184 (46%), Gaps = 20/184 (10%)
Query: 112 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL----------TAAACD---- 157
L+E+ + + +D+ + L C C LRTL L + R+ TA+
Sbjct: 565 LMEVTVYLQSDKDMMVSLYCLDY---CCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVY 621
Query: 158 --ELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACEN 215
E+ S +SLREL + N+L + +L + L H +CKL+TL+L S TA E+
Sbjct: 622 WREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFED 680
Query: 216 LYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAA 275
L L N++LT L + ++ LL L P C++ L L DL +A+
Sbjct: 681 LLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIAS 740
Query: 276 LRVT 279
L ++
Sbjct: 741 LLIS 744
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 162 bits (410), Expect = 3e-40
Identities = 98/256 (38%), Positives = 137/256 (53%)
Query: 30 LWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQL 89
L L C ++ DLS AL N++LT ++LS N + G LL LRHP+C LQ + L
Sbjct: 788 LGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSL 847
Query: 90 RKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKIC 149
C L C+++A+VL + L L L N + + G++ LC+GLR+P C+L+TL L C
Sbjct: 848 ENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNC 907
Query: 150 RLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLT 209
+T+ C +L L SL LDL LN +G G+ LCE LR P C L+ L L C +
Sbjct: 908 DITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIP 967
Query: 210 AKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMT 269
+CE+L L NQ+L L L N LG +GV++L + L+ LR L L D N
Sbjct: 968 PFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDEL 1027
Query: 270 HSRLAALRVTKPYLDI 285
+ L + P L I
Sbjct: 1028 NKLLEEIEEKNPQLII 1043
Score = 154 bits (388), Expect = 1e-37
Identities = 92/229 (40%), Positives = 129/229 (56%), Gaps = 5/229 (2%)
Query: 39 SSACEDLSAALIANKNLTRMDLSGNGVG--FPGMMLLCEGLRHPQCRLQMIQLRKCQLES 96
+ A +L AL +K +T + L GN FP LCE LRHP+C L+ + L C +
Sbjct: 741 ADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPA---LCEVLRHPECNLRYLGLVSCSATT 797
Query: 97 GACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAAC 156
+++ L N L ++L+ N L D G +LL LRHP C L+ L L+ C LT A C
Sbjct: 798 QQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANC 857
Query: 157 DELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENL 216
+LA+ L V++ L L L+ N +G+ GV LCEGLR+P CKLQTL L +C +T+ C +L
Sbjct: 858 KDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDL 917
Query: 217 YFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 265
L +L L L N +G G++ LC+ L P C LR LWL+G +
Sbjct: 918 TKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSI 966
Score = 144 bits (362), Expect = 1e-34
Identities = 74/176 (42%), Positives = 108/176 (61%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
QRL L+ C ++ + C+DL+A L+ ++ LT + L+ N +G G+ LCEGLR+P+C+LQ +
Sbjct: 843 QRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTL 902
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L C + S C ++ +L L+ LDL N + G++ LC+ LR P+C LR LWL
Sbjct: 903 VLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLW 962
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203
C + +C++L S LS NQSL LDL N LG GV +L E L + L+TLRL
Sbjct: 963 GCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRL 1018
Score = 131 bits (329), Expect = 8e-31
Identities = 81/222 (36%), Positives = 121/222 (54%), Gaps = 2/222 (0%)
Query: 44 DLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMA 103
DL + +NK+L + ++ + + + +LCE + C LQ + + + A + +
Sbjct: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLC 748
Query: 104 SVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTL 163
L + + L L GN +D+ LC+ LRHP C LR L L C T +L+ L
Sbjct: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
Query: 164 SVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGIN 223
VNQSL ++LS NEL D G LL LRHP C LQ L L++C LT C++L L ++
Sbjct: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
Query: 224 QTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 265
+ LT L L N +G+TGV+ LC+ L +P CKL+ L L+ D+
Sbjct: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDI 909
Score = 82.8 bits (203), Expect = 3e-16
Identities = 61/187 (32%), Positives = 92/187 (49%), Gaps = 2/187 (1%)
Query: 101 EMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELA 160
++ S+ G+N L+ L + + L +R+LC+ + C L+ + K A A L
Sbjct: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLC 748
Query: 161 STLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTL 220
L ++++ L L N+ D+ LCE LRHP C L+ L L SC T + +L L
Sbjct: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
Query: 221 GINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTK 280
+NQ+LT + L++N L D G +LL L HP C L+ L L L + LAA+ V
Sbjct: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
Query: 281 PYLDIGC 287
L C
Sbjct: 868 RELTHLC 874
Score = 81.3 bits (199), Expect = 9e-16
Identities = 51/130 (39%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
Query: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
GL P + Q L L C I+S C DL+ L +L +DL N +G GM LCE LR
Sbjct: 891 GLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALR 950
Query: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
P C L+ + L C + +C+++ S L N LV LDL N L G+++L + L
Sbjct: 951 KPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSS 1010
Query: 139 CRLRTLWLKI 148
LRTL LKI
Sbjct: 1011 GTLRTLRLKI 1020
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 151 bits (381), Expect = 7e-37
Identities = 88/184 (47%), Positives = 108/184 (58%)
Query: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L SCGLT+ C++L
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 279
L + +L +L L N L D GVRLLC+ L HP CKL L L L+ L AL
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 280 KPYL 283
KP L
Sbjct: 978 KPQL 981
Score = 148 bits (374), Expect = 5e-36
Identities = 79/172 (45%), Positives = 105/172 (61%)
Query: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
L + L +NL +DLSGN + + LC+ LR P+C L+ ++L C L + C+++A
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
L N L ELDL+ N L D G + LCQ LR P C+L+ L L C LT+ C +LAS LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENL 216
+ SL+ELDL N L D+GV LLCEGLRHP CKL L LD L+ + + L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 116 bits (290), Expect = 3e-26
Identities = 66/153 (43%), Positives = 92/153 (60%), Gaps = 2/153 (1%)
Query: 9 SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66
S+S + ++ L +PR + L L C +++ C+DL+ L AN+ LT +DLS N +
Sbjct: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
Query: 67 FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126
G LC+ LR P C+LQ +QL C L S CQ++ASVL +P L ELDL N L+D+G
Sbjct: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
Query: 127 LRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
+RLLC+GLRHP C+L L L L+ EL
Sbjct: 939 VRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 103 bits (257), Expect = 2e-22
Identities = 61/133 (45%), Positives = 77/133 (57%)
Query: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL CGLTA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270
+ C++L F L NQTLT+L L+ N L D G + LC+RL P CKL+ L L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 271 SRLAALRVTKPYL 283
LA++ P L
Sbjct: 912 QDLASVLSASPSL 924
Score = 65.5 bits (158), Expect = 5e-11
Identities = 36/94 (38%), Positives = 54/94 (57%), Gaps = 2/94 (2%)
Query: 22 LLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRH 79
L QP + QRL L C ++S C+DL++ L A+ +L +DL N + G+ LLCEGLRH
Sbjct: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH 948
Query: 80 PQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV 113
P C+L + L + L QE+ ++ P L+
Sbjct: 949 PACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 151 bits (381), Expect = 7e-37
Identities = 88/184 (47%), Positives = 108/184 (58%)
Query: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L SCGLT+ C++L
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 279
L + +L +L L N L D GVRLLC+ L HP CKL L L L+ L AL
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 280 KPYL 283
KP L
Sbjct: 978 KPQL 981
Score = 148 bits (374), Expect = 5e-36
Identities = 79/172 (45%), Positives = 105/172 (61%)
Query: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
L + L +NL +DLSGN + + LC+ LR P+C L+ ++L C L + C+++A
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
L N L ELDL+ N L D G + LCQ LR P C+L+ L L C LT+ C +LAS LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENL 216
+ SL+ELDL N L D+GV LLCEGLRHP CKL L LD L+ + + L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 116 bits (290), Expect = 3e-26
Identities = 66/153 (43%), Positives = 92/153 (60%), Gaps = 2/153 (1%)
Query: 9 SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66
S+S + ++ L +PR + L L C +++ C+DL+ L AN+ LT +DLS N +
Sbjct: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
Query: 67 FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126
G LC+ LR P C+LQ +QL C L S CQ++ASVL +P L ELDL N L+D+G
Sbjct: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
Query: 127 LRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
+RLLC+GLRHP C+L L L L+ EL
Sbjct: 939 VRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 103 bits (257), Expect = 2e-22
Identities = 61/133 (45%), Positives = 77/133 (57%)
Query: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL CGLTA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270
+ C++L F L NQTLT+L L+ N L D G + LC+RL P CKL+ L L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 271 SRLAALRVTKPYL 283
LA++ P L
Sbjct: 912 QDLASVLSASPSL 924
Score = 65.5 bits (158), Expect = 5e-11
Identities = 36/94 (38%), Positives = 54/94 (57%), Gaps = 2/94 (2%)
Query: 22 LLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRH 79
L QP + QRL L C ++S C+DL++ L A+ +L +DL N + G+ LLCEGLRH
Sbjct: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH 948
Query: 80 PQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV 113
P C+L + L + L QE+ ++ P L+
Sbjct: 949 PACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 151 bits (381), Expect = 7e-37
Identities = 88/184 (47%), Positives = 108/184 (58%)
Query: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L SCGLT+ C++L
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 279
L + +L +L L N L D GVRLLC+ L HP CKL L L L+ L AL
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 280 KPYL 283
KP L
Sbjct: 978 KPQL 981
Score = 148 bits (374), Expect = 5e-36
Identities = 79/172 (45%), Positives = 105/172 (61%)
Query: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
L + L +NL +DLSGN + + LC+ LR P+C L+ ++L C L + C+++A
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
L N L ELDL+ N L D G + LCQ LR P C+L+ L L C LT+ C +LAS LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENL 216
+ SL+ELDL N L D+GV LLCEGLRHP CKL L LD L+ + + L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 116 bits (290), Expect = 3e-26
Identities = 66/153 (43%), Positives = 92/153 (60%), Gaps = 2/153 (1%)
Query: 9 SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66
S+S + ++ L +PR + L L C +++ C+DL+ L AN+ LT +DLS N +
Sbjct: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
Query: 67 FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126
G LC+ LR P C+LQ +QL C L S CQ++ASVL +P L ELDL N L+D+G
Sbjct: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
Query: 127 LRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
+RLLC+GLRHP C+L L L L+ EL
Sbjct: 939 VRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 103 bits (257), Expect = 2e-22
Identities = 61/133 (45%), Positives = 77/133 (57%)
Query: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL CGLTA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270
+ C++L F L NQTLT+L L+ N L D G + LC+RL P CKL+ L L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 271 SRLAALRVTKPYL 283
LA++ P L
Sbjct: 912 QDLASVLSASPSL 924
Score = 65.5 bits (158), Expect = 5e-11
Identities = 36/94 (38%), Positives = 54/94 (57%), Gaps = 2/94 (2%)
Query: 22 LLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRH 79
L QP + QRL L C ++S C+DL++ L A+ +L +DL N + G+ LLCEGLRH
Sbjct: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH 948
Query: 80 PQCRLQMIQLRKCQLESGACQEMASVLGTNPHLV 113
P C+L + L + L QE+ ++ P L+
Sbjct: 949 PACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 144 bits (364), Expect = 7e-35
Identities = 79/156 (50%), Positives = 98/156 (62%)
Query: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L SCGLT+ C++L
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 255
L + +L +L L N L D GVRLLC+ L HP CKL
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 144 bits (363), Expect = 9e-35
Identities = 74/154 (48%), Positives = 97/154 (62%)
Query: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
L + L +NL +DLSGN + + LC+ LR P+C L+ ++L C L + C+++A
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
L N L ELDL+ N L D G + LCQ LR P C+L+ L L C LT+ C +LAS LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
+ SL+ELDL N L D+GV LLCEGLRHP CKL
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 115 bits (287), Expect = 6e-26
Identities = 61/135 (45%), Positives = 86/135 (63%), Gaps = 2/135 (1%)
Query: 9 SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66
S+S + ++ L +PR + L L C +++ C+DL+ L AN+ LT +DLS N +
Sbjct: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
Query: 67 FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126
G LC+ LR P C+LQ +QL C L S CQ++ASVL +P L ELDL N L+D+G
Sbjct: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
Query: 127 LRLLCQGLRHPVCRL 141
+RLLC+GLRHP C+L
Sbjct: 939 VRLLCEGLRHPACKL 953
Score = 103 bits (257), Expect = 2e-22
Identities = 61/133 (45%), Positives = 77/133 (57%)
Query: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL CGLTA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270
+ C++L F L NQTLT+L L+ N L D G + LC+RL P CKL+ L L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 271 SRLAALRVTKPYL 283
LA++ P L
Sbjct: 912 QDLASVLSASPSL 924
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 144 bits (364), Expect = 7e-35
Identities = 79/156 (50%), Positives = 98/156 (62%)
Query: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Q + SVL +L ELDL+GN+L ++ LC+ LR P C L TL L C LTA C +L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
A L NQ+L ELDLS N L D G LC+ LR P+CKLQ L+L SCGLT+ C++L
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 255
L + +L +L L N L D GVRLLC+ L HP CKL
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 144 bits (363), Expect = 9e-35
Identities = 74/154 (48%), Positives = 97/154 (62%)
Query: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
L + L +NL +DLSGN + + LC+ LR P+C L+ ++L C L + C+++A
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
L N L ELDL+ N L D G + LCQ LR P C+L+ L L C LT+ C +LAS LS
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
+ SL+ELDL N L D+GV LLCEGLRHP CKL
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 115 bits (287), Expect = 6e-26
Identities = 61/135 (45%), Positives = 86/135 (63%), Gaps = 2/135 (1%)
Query: 9 SVSPATQEAKAGGLLQPR--RQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVG 66
S+S + ++ L +PR + L L C +++ C+DL+ L AN+ LT +DLS N +
Sbjct: 819 SLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLT 878
Query: 67 FPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLG 126
G LC+ LR P C+LQ +QL C L S CQ++ASVL +P L ELDL N L+D+G
Sbjct: 879 DAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVG 938
Query: 127 LRLLCQGLRHPVCRL 141
+RLLC+GLRHP C+L
Sbjct: 939 VRLLCEGLRHPACKL 953
Score = 103 bits (257), Expect = 2e-22
Identities = 61/133 (45%), Positives = 77/133 (57%)
Query: 151 LTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTA 210
+T A L S L V ++L+ELDLS N L V LC+ LR P C L+TLRL CGLTA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 211 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTH 270
+ C++L F L NQTLT+L L+ N L D G + LC+RL P CKL+ L L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 271 SRLAALRVTKPYL 283
LA++ P L
Sbjct: 912 QDLASVLSASPSL 924
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 135 bits (339), Expect = 5e-32
Identities = 85/239 (35%), Positives = 127/239 (53%), Gaps = 1/239 (0%)
Query: 49 LIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGT 108
L AN++L + LS N + G MLL + + P+ LQM+ L C+L +C+++A+VL
Sbjct: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
Query: 109 NPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQS 168
+ L L L N + D G++ LC+GL +P C+L+TL L+ C +T C L+ L S
Sbjct: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACS 904
Query: 169 LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTD 228
L LDLS+N++ G+ +LC+ L +P C L+ LRL SC L C++L L NQ L
Sbjct: 905 LTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLET 963
Query: 229 LYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 287
L L N L +G+ L L L++L L + N L ++ P L I C
Sbjct: 964 LDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDC 1022
Score = 130 bits (328), Expect = 1e-30
Identities = 88/227 (38%), Positives = 121/227 (53%), Gaps = 2/227 (0%)
Query: 40 SACEDLSAALIANKNLTRMDLSGNGVGFPGMML-LCEGLRHPQCRLQMIQLRKCQLESGA 98
+A D A I K LT + L+G+ MML LC+ LR+ +C LQ ++L
Sbjct: 718 TAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQ 777
Query: 99 CQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDE 158
E VL N L L L+ N L D G LL + + P L+ L L+ CRLT A+C +
Sbjct: 778 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 837
Query: 159 LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYF 218
LA+ L V++ L L L+ N +GD GV LCEGL +P CKLQTL L C +T C L
Sbjct: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
Query: 219 TLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 265
L +LT+L L+ N + G+ +LC+ L +P C L+ L L+ L
Sbjct: 898 ALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSL 943
Score = 123 bits (308), Expect = 2e-28
Identities = 69/176 (39%), Positives = 99/176 (56%), Gaps = 1/176 (0%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q L L+ CR++ ++C+DL+A L+ +K LT + L+ N +G G+ LCEGL +P C+LQ +
Sbjct: 821 QMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTL 880
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L++C + C+ ++ L L LDL+ N + GL +LCQ L +P C L+ L L
Sbjct: 881 VLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLW 939
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203
C L C L S L NQ L LDL N L G++ L LR T L+ LRL
Sbjct: 940 SCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
Score = 109 bits (273), Expect = 2e-24
Identities = 77/244 (31%), Positives = 119/244 (48%), Gaps = 13/244 (5%)
Query: 26 RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQ 85
R RLW C + SS N NL +++ + + + +LC+ + C LQ
Sbjct: 659 RSLRLWTDFCSLFSS-----------NSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ 707
Query: 86 MIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNA-LEDLGLRLLCQGLRHPVCRLRTL 144
++++ ++ + +G L L L G+ E + +LC LR+ C L+ L
Sbjct: 708 KVEIKNVTPDTAYRDFCLAFIGKKT-LTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYL 766
Query: 145 WLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLD 204
L T E L NQSL+ L LS N L D G +LL + + P LQ L L+
Sbjct: 767 RLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLE 826
Query: 205 SCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMD 264
+C LT +C++L L +++ LT L L N +GDTGV+ LC+ LS+P CKL+ L L
Sbjct: 827 NCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCS 886
Query: 265 LNKM 268
+ K+
Sbjct: 887 ITKL 890
Score = 64.7 bits (156), Expect = 9e-11
Identities = 54/188 (28%), Positives = 89/188 (47%), Gaps = 2/188 (1%)
Query: 101 EMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELA 160
+ S+ +N +L L++ + L D +R+LC + C L+ + +K A D
Sbjct: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCL 725
Query: 161 STLSVNQSLRELDLSLN-ELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
+ + ++L L L+ + E +L+LC+ LR+ C LQ LRL T + ++
Sbjct: 726 AFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
Query: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 279
L NQ+L L L+ N L D G LL K ++ P L++L L L + + LAA+ V
Sbjct: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
Query: 280 KPYLDIGC 287
L C
Sbjct: 845 SKKLTHLC 852
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 135 bits (339), Expect = 5e-32
Identities = 93/249 (37%), Positives = 128/249 (51%), Gaps = 2/249 (0%)
Query: 40 SACEDLSAALIANKNLTRMDLSGNGVGFPGMML-LCEGLRHPQCRLQMIQLRKCQLESGA 98
+A D A I K LT + L+G+ MML LC+ LR+ +C LQ ++L
Sbjct: 718 TAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQ 777
Query: 99 CQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDE 158
E VL N L L L+ N L D G LL + + P L+ L L+ CRLT A+C +
Sbjct: 778 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 837
Query: 159 LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYF 218
LA+ L V++ L L L+ N +GD GV LCEGL +P CKLQTL L C +T C L
Sbjct: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
Query: 219 TLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRV 278
L +LT+L L+ N + G+ +LC+ L +P C L+ L L + N L ++
Sbjct: 898 ALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKE 956
Query: 279 TKPYLDIGC 287
P L I C
Sbjct: 957 KNPKLTIDC 965
Score = 94.0 bits (232), Expect = 1e-19
Identities = 47/120 (39%), Positives = 74/120 (61%), Gaps = 1/120 (0%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q L L+ CR++ ++C+DL+A L+ +K LT + L+ N +G G+ LCEGL +P C+LQ +
Sbjct: 821 QMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTL 880
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L++C + C+ ++ L L LDL+ N + GL +LCQ L +P C L+ L LK
Sbjct: 881 VLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLK 939
Score = 85.9 bits (211), Expect = 4e-17
Identities = 64/225 (28%), Positives = 95/225 (42%), Gaps = 57/225 (25%)
Query: 101 EMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL------------------- 141
+ S+ +N +L L++ + L D +R+LC + C L
Sbjct: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCL 725
Query: 142 --------------------RTLWLKICRL------------------TAAACDELASTL 163
RT+ L +C L T E L
Sbjct: 726 AFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVL 785
Query: 164 SVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGIN 223
NQSL+ L LS N L D G +LL + + P LQ L L++C LT +C++L L ++
Sbjct: 786 KANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVS 845
Query: 224 QTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
+ LT L L N +GDTGV+ LC+ LS+P CKL+ L L + K+
Sbjct: 846 KKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKL 890
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 135 bits (339), Expect = 5e-32
Identities = 85/239 (35%), Positives = 127/239 (53%), Gaps = 1/239 (0%)
Query: 49 LIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGT 108
L AN++L + LS N + G MLL + + P+ LQM+ L C+L +C+++A+VL
Sbjct: 757 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 816
Query: 109 NPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQS 168
+ L L L N + D G++ LC+GL +P C+L+TL L+ C +T C L+ L S
Sbjct: 817 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACS 876
Query: 169 LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTD 228
L LDLS+N++ G+ +LC+ L +P C L+ LRL SC L C++L L NQ L
Sbjct: 877 LTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLET 935
Query: 229 LYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 287
L L N L +G+ L L L++L L + N L ++ P L I C
Sbjct: 936 LDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDC 994
Score = 130 bits (328), Expect = 1e-30
Identities = 88/227 (38%), Positives = 121/227 (53%), Gaps = 2/227 (0%)
Query: 40 SACEDLSAALIANKNLTRMDLSGNGVGFPGMML-LCEGLRHPQCRLQMIQLRKCQLESGA 98
+A D A I K LT + L+G+ MML LC+ LR+ +C LQ ++L
Sbjct: 690 TAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQ 749
Query: 99 CQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDE 158
E VL N L L L+ N L D G LL + + P L+ L L+ CRLT A+C +
Sbjct: 750 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 809
Query: 159 LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYF 218
LA+ L V++ L L L+ N +GD GV LCEGL +P CKLQTL L C +T C L
Sbjct: 810 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 869
Query: 219 TLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 265
L +LT+L L+ N + G+ +LC+ L +P C L+ L L+ L
Sbjct: 870 ALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSL 915
Score = 123 bits (308), Expect = 2e-28
Identities = 69/176 (39%), Positives = 99/176 (56%), Gaps = 1/176 (0%)
Query: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Q L L+ CR++ ++C+DL+A L+ +K LT + L+ N +G G+ LCEGL +P C+LQ +
Sbjct: 793 QMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTL 852
Query: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
L++C + C+ ++ L L LDL+ N + GL +LCQ L +P C L+ L L
Sbjct: 853 VLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLW 911
Query: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRL 203
C L C L S L NQ L LDL N L G++ L LR T L+ LRL
Sbjct: 912 SCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 967
Score = 105 bits (263), Expect = 4e-23
Identities = 70/219 (31%), Positives = 112/219 (51%), Gaps = 2/219 (0%)
Query: 51 ANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNP 110
+N NL +++ + + + +LC+ + C LQ ++++ ++ + +G
Sbjct: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKT 704
Query: 111 HLVELDLTGNA-LEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSL 169
L L L G+ E + +LC LR+ C L+ L L T E L NQSL
Sbjct: 705 -LTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
Query: 170 RELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTDL 229
+ L LS N L D G +LL + + P LQ L L++C LT +C++L L +++ LT L
Sbjct: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 823
Query: 230 YLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
L N +GDTGV+ LC+ LS+P CKL+ L L + K+
Sbjct: 824 CLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKL 862
Score = 62.0 bits (149), Expect = 6e-10
Identities = 53/181 (29%), Positives = 86/181 (47%), Gaps = 2/181 (1%)
Query: 108 TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 167
+N +L L++ + L D +R+LC + C L+ + +K A D + + +
Sbjct: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIG-KK 703
Query: 168 SLRELDLSLN-ELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTL 226
+L L L+ + E +L+LC+ LR+ C LQ LRL T + ++ L NQ+L
Sbjct: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
Query: 227 TDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIG 286
L L+ N L D G LL K ++ P L++L L L + + LAA+ V L
Sbjct: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHL 823
Query: 287 C 287
C
Sbjct: 824 C 824
Score = 34.7 bits (78), Expect = 0.099
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 2/100 (2%)
Query: 164 SVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGIN 223
S N +L+ L++ + L D V +LC+ + TC LQ + + + + +G
Sbjct: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIG-K 702
Query: 224 QTLTDLYLTNNALGD-TGVRLLCKRLSHPGCKLRVLWLFG 262
+TLT L L + + T + +LC L + C L+ L L G
Sbjct: 703 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGG 742
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,952,558
Number of Sequences: 37866
Number of extensions: 448236
Number of successful extensions: 2006
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 1469
Number of HSP's gapped (non-prelim): 327
length of query: 287
length of database: 18,247,518
effective HSP length: 101
effective length of query: 186
effective length of database: 14,423,052
effective search space: 2682687672
effective search space used: 2682687672
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.