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Search of human proteins with 150417996
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo
sapiens]
(1052 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens] 2127 0.0
gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens] 757 0.0
gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens] 757 0.0
gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo sa... 583 e-166
gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens] 120 7e-27
gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens] 117 6e-26
gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens] 117 6e-26
gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo s... 87 1e-16
gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo s... 87 1e-16
gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 87 1e-16
gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo sap... 85 3e-16
gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens] 65 3e-10
gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo ... 64 7e-10
gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo... 59 2e-08
gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens] 52 4e-06
gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens] 52 4e-06
gi|66363688 NEDD8 activating enzyme E1 subunit 1 isoform c [Homo... 48 4e-05
gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens] 34 0.83
gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens] 34 0.83
gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens] 34 0.83
gi|110349719 titin isoform N2-A [Homo sapiens] 34 0.83
gi|110349717 titin isoform novex-2 [Homo sapiens] 34 0.83
gi|110349713 titin isoform novex-1 [Homo sapiens] 34 0.83
gi|110349715 titin isoform N2-B [Homo sapiens] 34 0.83
gi|50811873 suppressor of hairy wing homolog 4 isoform 2 [Homo s... 32 2.4
gi|50811871 suppressor of hairy wing homolog 4 isoform 1 [Homo s... 32 2.4
gi|98986445 carcinoembryonic antigen-related cell adhesion molec... 31 5.4
gi|41872631 fatty acid synthase [Homo sapiens] 30 9.2
>gi|150417996 ubiquitin-activating enzyme E1-like 2 [Homo sapiens]
Length = 1052
Score = 2127 bits (5511), Expect = 0.0
Identities = 1052/1052 (100%), Positives = 1052/1052 (100%)
Query: 1 MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMA 60
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMA
Sbjct: 1 MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMA 60
Query: 61 KSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAE 120
KSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAE
Sbjct: 61 KSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAE 120
Query: 121 AVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPP 180
AVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPP
Sbjct: 121 AVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPP 180
Query: 181 IKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLE 240
IKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLE
Sbjct: 181 IKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLE 240
Query: 241 TGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE 300
TGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE
Sbjct: 241 TGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE 300
Query: 301 SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATS 360
SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATS
Sbjct: 301 SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATS 360
Query: 361 ISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE 420
ISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE
Sbjct: 361 ISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE 420
Query: 421 AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFA 480
AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFA
Sbjct: 421 AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFA 480
Query: 481 LLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDA 540
LLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDA
Sbjct: 481 LLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDA 540
Query: 541 HLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT 600
HLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT
Sbjct: 541 HLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT 600
Query: 601 EVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFW 660
EVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFW
Sbjct: 601 EVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFW 660
Query: 661 QTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLH 720
QTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLH
Sbjct: 661 QTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLH 720
Query: 721 CFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSA 780
CFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSA
Sbjct: 721 CFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSA 780
Query: 781 DALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS 840
DALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS
Sbjct: 781 DALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS 840
Query: 841 DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT 900
DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT
Sbjct: 841 DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT 900
Query: 901 VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTV 960
VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTV
Sbjct: 901 VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTV 960
Query: 961 HGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKK 1020
HGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKK
Sbjct: 961 HGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKK 1020
Query: 1021 YVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD 1052
YVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD
Sbjct: 1021 YVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD 1052
>gi|23510338 ubiquitin-activating enzyme E1 [Homo sapiens]
Length = 1058
Score = 757 bits (1955), Expect = 0.0
Identities = 436/1033 (42%), Positives = 626/1033 (60%), Gaps = 45/1033 (4%)
Query: 35 ASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTE 94
+ +ID+ LYSRQ YVLG AM+++ S V +SG+ GLG+EIAKN++L G+KAVT+HD
Sbjct: 46 SEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQG 105
Query: 95 KCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKY 154
Q DL + F+L E+D+ +NRAE +AELN YV VT+ + P E FL +
Sbjct: 106 TAQWADLSSQFYLREEDI--GKNRAEVSQPRLAELNSYVPVTAYTGPLVE----DFLSGF 159
Query: 155 QCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPK 214
Q VVLT L Q ++ +FC ++ IK + AD G++ +LFCDFG+E + D+ GE+P
Sbjct: 160 QVVVLTNTPLEDQLRVGEFCHNR--GIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPL 217
Query: 215 EIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSI-QQITVISPFSFSI 273
+S +T+ NPG+VTCL+ H E+G F++F E+ GM LNG+ +I V+ P++FSI
Sbjct: 218 SAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSI 277
Query: 274 GDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALD 333
DT+ Y+ GGI QVK PK + F+SL L P ++ DF+ P ++H AL
Sbjct: 278 CDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALH 337
Query: 334 QFQEKYSRKPNVGCQQDSEELLKLATSISETL---EEKPDVNADIVHWLSWTAQGFLSPL 390
QF ++ R P ++D+ EL+ LA +++ ++ +++ D++ L++ A G L+P+
Sbjct: 338 QFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPI 397
Query: 391 AAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIV----ESLGKPECEEFLPRGDRYDAL 446
A +GG+A+QEV+KA +GKF P+ QWLY +A + + E L + +C L R +RYD
Sbjct: 398 NAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEVLTEDKC---LQRQNRYDGQ 454
Query: 447 RACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNL 506
A G L +KL FLVG GAIGCE+LKNFA++G+G E G I VTD D IEKSNL
Sbjct: 455 VAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCG-EGGEIIVTDMDTIEKSNL 513
Query: 507 NRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIIT 566
NRQFLFRP + K KS TAA A ++N I++ +H N+V P TE IY+D+F+ D +
Sbjct: 514 NRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVAN 573
Query: 567 ALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCT 626
ALDNV+AR Y+D RC+ +PLL+SGT+GTKG+ +V++P LTESY+S +DPPE+ IP CT
Sbjct: 574 ALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICT 633
Query: 627 LKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVI 686
LK+FP AIEHT+QWARD+FE F N++ E L ++ LE V
Sbjct: 634 LKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTL-RLAGTQPLEVLEAVQ 692
Query: 687 K-LLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPI 745
+ L+ +RP+ W+ CV A + +++ QLLH FP D G+ FW PKR P P+
Sbjct: 693 RSLVLQRPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPL 752
Query: 746 KFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSN--KVVQ 803
FD+N PLHL ++ AA L+A Y + +++ A+ L V++ EF P + K+
Sbjct: 753 TFDVNNPLHLDYVMAAANLFAQTYGLTGSQD---RAAVATFLQSVQVPEFTPKSGVKIHV 809
Query: 804 TDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFIT 863
+D+ + + S +D R + KA L + +M + FEKDDD N H+DFI
Sbjct: 810 SDQELQSAN---ASVDDSR---LEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIV 863
Query: 864 AASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGGY-PFEAYK 922
AASNLRA+ Y I ADR K+K IAGKIIPAIATTTA V GLV LE+ KV G+ ++YK
Sbjct: 864 AASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYK 923
Query: 923 NCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHG----KEDFTLLDFINAVKEK 978
N FLNLA+P F+E + + N +T+WDR+ V G E+ TL F++ K +
Sbjct: 924 NGFLNLALPFFGFSEPLAAPRHQYYNQ-EWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTE 982
Query: 979 YGIEPTMVVQGVKMLYVPVMPGH--AKRLKLTMHKLVKPTTEKK----YVDLTVSFAPDI 1032
+ +E TM+ QGV MLY MP +RL M ++V +++K L + +
Sbjct: 983 HKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCND 1042
Query: 1033 DGDEDLPGPPVRY 1045
+ ED+ P VRY
Sbjct: 1043 ESGEDVEVPYVRY 1055
>gi|23510340 ubiquitin-activating enzyme E1 [Homo sapiens]
Length = 1058
Score = 757 bits (1955), Expect = 0.0
Identities = 436/1033 (42%), Positives = 626/1033 (60%), Gaps = 45/1033 (4%)
Query: 35 ASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTE 94
+ +ID+ LYSRQ YVLG AM+++ S V +SG+ GLG+EIAKN++L G+KAVT+HD
Sbjct: 46 SEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQG 105
Query: 95 KCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKY 154
Q DL + F+L E+D+ +NRAE +AELN YV VT+ + P E FL +
Sbjct: 106 TAQWADLSSQFYLREEDI--GKNRAEVSQPRLAELNSYVPVTAYTGPLVE----DFLSGF 159
Query: 155 QCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPK 214
Q VVLT L Q ++ +FC ++ IK + AD G++ +LFCDFG+E + D+ GE+P
Sbjct: 160 QVVVLTNTPLEDQLRVGEFCHNR--GIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPL 217
Query: 215 EIFISNITQANPGIVTCLENHPHKLETGQFLTFREINGMTGLNGSI-QQITVISPFSFSI 273
+S +T+ NPG+VTCL+ H E+G F++F E+ GM LNG+ +I V+ P++FSI
Sbjct: 218 SAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSI 277
Query: 274 GDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLALD 333
DT+ Y+ GGI QVK PK + F+SL L P ++ DF+ P ++H AL
Sbjct: 278 CDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALH 337
Query: 334 QFQEKYSRKPNVGCQQDSEELLKLATSISETL---EEKPDVNADIVHWLSWTAQGFLSPL 390
QF ++ R P ++D+ EL+ LA +++ ++ +++ D++ L++ A G L+P+
Sbjct: 338 QFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPI 397
Query: 391 AAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIV----ESLGKPECEEFLPRGDRYDAL 446
A +GG+A+QEV+KA +GKF P+ QWLY +A + + E L + +C L R +RYD
Sbjct: 398 NAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEVLTEDKC---LQRQNRYDGQ 454
Query: 447 RACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNL 506
A G L +KL FLVG GAIGCE+LKNFA++G+G E G I VTD D IEKSNL
Sbjct: 455 VAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCG-EGGEIIVTDMDTIEKSNL 513
Query: 507 NRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIIT 566
NRQFLFRP + K KS TAA A ++N I++ +H N+V P TE IY+D+F+ D +
Sbjct: 514 NRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVAN 573
Query: 567 ALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCT 626
ALDNV+AR Y+D RC+ +PLL+SGT+GTKG+ +V++P LTESY+S +DPPE+ IP CT
Sbjct: 574 ALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICT 633
Query: 627 LKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGCFQVI 686
LK+FP AIEHT+QWARD+FE F N++ E L ++ LE V
Sbjct: 634 LKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTL-RLAGTQPLEVLEAVQ 692
Query: 687 K-LLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPPSPI 745
+ L+ +RP+ W+ CV A + +++ QLLH FP D G+ FW PKR P P+
Sbjct: 693 RSLVLQRPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPL 752
Query: 746 KFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSN--KVVQ 803
FD+N PLHL ++ AA L+A Y + +++ A+ L V++ EF P + K+
Sbjct: 753 TFDVNNPLHLDYVMAAANLFAQTYGLTGSQD---RAAVATFLQSVQVPEFTPKSGVKIHV 809
Query: 804 TDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFIT 863
+D+ + + S +D R + KA L + +M + FEKDDD N H+DFI
Sbjct: 810 SDQELQSAN---ASVDDSR---LEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIV 863
Query: 864 AASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGGY-PFEAYK 922
AASNLRA+ Y I ADR K+K IAGKIIPAIATTTA V GLV LE+ KV G+ ++YK
Sbjct: 864 AASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYK 923
Query: 923 NCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTVHG----KEDFTLLDFINAVKEK 978
N FLNLA+P F+E + + N +T+WDR+ V G E+ TL F++ K +
Sbjct: 924 NGFLNLALPFFGFSEPLAAPRHQYYNQ-EWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTE 982
Query: 979 YGIEPTMVVQGVKMLYVPVMPGH--AKRLKLTMHKLVKPTTEKK----YVDLTVSFAPDI 1032
+ +E TM+ QGV MLY MP +RL M ++V +++K L + +
Sbjct: 983 HKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCND 1042
Query: 1033 DGDEDLPGPPVRY 1045
+ ED+ P VRY
Sbjct: 1043 ESGEDVEVPYVRY 1055
>gi|38045948 ubiquitin-like modifier activating enzyme 7 [Homo
sapiens]
Length = 1012
Score = 583 bits (1503), Expect = e-166
Identities = 385/1037 (37%), Positives = 565/1037 (54%), Gaps = 58/1037 (5%)
Query: 35 ASVEIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTE 94
AS +D+ LYSRQ YVLG AMQ++ + V +SG+ GLG E+AKNLVL G+ ++T+HD
Sbjct: 6 ASKLLDEELYSRQLYVLGSPAMQRIQGARVLVSGLQGLGAEVAKNLVLMGVGSLTLHDPH 65
Query: 95 KCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKY 154
DL F LSE D+ +R+RAEA + +A+LN V V V + T+ LD +
Sbjct: 66 PTCWSDLAAQFLLSEQDL--ERSRAEASQELLAQLNRAVQVV---VHTGDITEDLLLD-F 119
Query: 155 QCVVLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPK 214
Q VVLT KL Q K+ C + F++AD G+ +LFCDFG++F V D T EP
Sbjct: 120 QVVVLTAAKLEEQLKVGTLCHKH--GVCFLAADTRGLVGQLFCDFGEDFTVQDPTEAEPL 177
Query: 215 EIFISNITQANPGIVTCLEN-HPHKLETGQFLTFREINGMTGLNG-SIQQITVISPFSFS 272
I +I+Q +PGI+T + + H G +TF I GM LN + I V S
Sbjct: 178 TAAIQHISQGSPGILTLRKGANTHYFRDGDLVTFSGIEGMVELNDCDPRSIHVREDGSLE 237
Query: 273 IGDTTELEPYLHGGIAVQVKTPKTVFFESLERQLKHPKCLIVDFSNPEAPLEIHTAMLAL 332
IGDTT YL GG +VK PKTV +SL+ L P + +H A AL
Sbjct: 238 IGDTTTFSRYLRGGAITEVKRPKTVRHKSLDTALLQPHVVAQSSQEVHHAHCLHQAFCAL 297
Query: 333 DQFQEKYSRKPNVGCQQDSEELLKLATSIS--ETLEEKP---DVNADIVHWLSWTAQGFL 387
+FQ + R P D+E ++ LA + + EE+P ++ +V ++ ++ G L
Sbjct: 298 HKFQHLHGRPPQPWDPVDAETVVGLARDLEPLKRTEEEPLEEPLDEALVRTVALSSAGVL 357
Query: 388 SPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADIVESLGK--PECEEFLPRGDRYDA 445
SP+ A +G VA+QEVLKA++ KF PL QWLY +A D + G+ P E+ RG RYD
Sbjct: 358 SPMVAMLGAVAAQEVLKAISRKFMPLDQWLYFDALDCLPEDGELLPSPEDCALRGSRYDG 417
Query: 446 LRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSN 505
A G +KL+ + LVG GAIGCE+LK FAL+G+G G+ TV D D IE+SN
Sbjct: 418 QIAVFGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGL-TVVDMDHIERSN 476
Query: 506 LNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVII 565
L+RQFLFR + +PK+ AA A +N +++ + PTTE IY D F+++ D +
Sbjct: 477 LSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPTTEHIYGDNFFSRVDGVA 536
Query: 566 TALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEE---I 622
ALD+ +ARRYV +RC L+PLL++GT GT G V +PH+TE+Y + E
Sbjct: 537 AALDSFQARRYVAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPASAAASEDAPY 596
Query: 623 PFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFWQTYSSAEEVLQKIQSGHSLEGC 682
P CT++ FP+ EHT+QWAR +FE F N Q ++S L + +L
Sbjct: 597 PVCTVRYFPSTAEHTLQWARHEFEELFRLSAETINHHQQAHTS----LADMDEPQTLTLL 652
Query: 683 FQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLHCFPLDIRLKDGSLFWQSPKRPP 742
V+ +L RP+NW CV A ++ F++ QLL FP + L+DG+ FW PK+ P
Sbjct: 653 KPVLGVLRVRPQNWQDCVAWALGHWKLCFHYGIKQLLRHFPPNKVLEDGTPFWSGPKQCP 712
Query: 743 SPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSADALLNILSEVKIQEFKPSNKVV 802
P++FD N+ HL ++ AA LYA ++ +P +++ + LL +L + Q+ P
Sbjct: 713 QPLEFDTNQDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQPDPQQMAPI---- 768
Query: 803 QTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKSDLQMAVLSFEKDDDHNGHIDFI 862
A + S+E +L KA+ E + L FEKDDD N H+DF+
Sbjct: 769 ----FASNLELASASAEFGPEQQKELNKAL---EVWSVGPPLKPLMFEKDDDSNFHVDFV 821
Query: 863 TAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIKVTGG-YPFEAY 921
AA++LR + Y I P +R ++KRI G+IIPAIATTTA V+GL+ LE+ KV G P A+
Sbjct: 822 VAAASLRCQNYGIPPVNRAQSKRIVGQIIPAIATTTAAVAGLLGLELYKVVSGPRPRSAF 881
Query: 922 KNCFLNLA----IPIVVFTETTEVRKTKIRNGISFTIWDRWTV-HGKEDFTLLDFINAVK 976
++ +L+LA I + F + + + +T WDR V G+ + TL + ++
Sbjct: 882 RHSYLHLAENYLIRYMPFAPAIQT-----FHHLKWTSWDRLKVPAGQPERTLESLLAHLQ 936
Query: 977 EKYGIEPTMVVQGVKMLYVP--VMPGHAKRLKLTMHKLVK------PTTEKKYVDLTVSF 1028
E++G+ +++ G +LY A+ L L + +LV+ P ++ + L +S
Sbjct: 937 EQHGLRVRILLHGSALLYAAGWSPEKQAQHLPLRVTELVQQLTGQAPAPGQRVLVLELSC 996
Query: 1029 APDIDGDEDLPGPPVRY 1045
D DED PP+ Y
Sbjct: 997 EGD---DEDTAFPPLHY 1010
>gi|4885649 SUMO-1 activating enzyme subunit 2 [Homo sapiens]
Length = 640
Score = 120 bits (301), Expect = 7e-27
Identities = 69/199 (34%), Positives = 104/199 (52%), Gaps = 9/199 (4%)
Query: 454 LCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFR 513
L + + + +VG G IGCE+LKN L G I + D D I+ SNLNRQFLF+
Sbjct: 11 LAEAVAGGRVLVVGAGGIGCELLKNLVLTGFSH------IDLIDLDTIDVSNLNRQFLFQ 64
Query: 514 PHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEA 573
H+ + K+ A ++ L+ + I A+ + + YN EF+ + +++ ALDN A
Sbjct: 65 KKHVGRSKAQVAKESVLQFYPKANIVAYHDSIMNPD---YNVEFFRQFILVMNALDNRAA 121
Query: 574 RRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAA 633
R +V+ CLA PL++SGT G G I +TE Y H P + P CT+++ P+
Sbjct: 122 RNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVTECYECHPKPTQRTFPGCTIRNTPSE 181
Query: 634 IEHTIQWARDKFESSFSHK 652
H I WA+ F F +
Sbjct: 182 PIHCIVWAKYLFNQLFGEE 200
Score = 66.2 bits (160), Expect = 2e-10
Identities = 36/83 (43%), Positives = 53/83 (63%), Gaps = 3/83 (3%)
Query: 845 AVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGL 904
A L ++KDD +DF+T+A+NLR ++S+ RF K +AG IIPAIATT A ++GL
Sbjct: 340 AELIWDKDDP--SAMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGL 397
Query: 905 VALEMIKVTGGYPFEAYKNCFLN 927
+ LE +K+ G + + FLN
Sbjct: 398 IVLEGLKILSG-KIDQCRTIFLN 419
Score = 41.2 bits (95), Expect = 0.005
Identities = 38/181 (20%), Positives = 70/181 (38%), Gaps = 31/181 (17%)
Query: 57 QKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKR 116
+ +A V + G GG+G E+ KNLVL G + + D + +L F + V R
Sbjct: 13 EAVAGGRVLVVGAGGIGCELLKNLVLTGFSHIDLIDLDTIDVSNLNRQFLFQKKHV--GR 70
Query: 117 NRAEAVLKHIAELNPYVHVTS-SSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCR 175
++A+ + + + P ++ + N ++ F ++ V+ + +N C
Sbjct: 71 SKAQVAKESVLQFYPKANIVAYHDSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMC- 129
Query: 176 SQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENH 235
++ADV I S T G ++ +T G+ C E H
Sbjct: 130 --------LAADVPLIES-------------GTAG------YLGQVTTIKKGVTECYECH 162
Query: 236 P 236
P
Sbjct: 163 P 163
>gi|38045944 ubiquitin-activating enzyme 3 isoform 2 [Homo sapiens]
Length = 449
Score = 117 bits (293), Expect = 6e-26
Identities = 70/199 (35%), Positives = 101/199 (50%), Gaps = 25/199 (12%)
Query: 458 LQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHI 517
L + ++G G +GCE+LKN AL G I V D D I+ SNLNRQFLFRP I
Sbjct: 53 LDTCKVLVIGAGGLGCELLKNLALSGFR------QIHVIDMDTIDVSNLNRQFLFRPKDI 106
Query: 518 QKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYV 577
+PK+ AA+ + H NK+ +ND FY + +I+ LD++ ARR++
Sbjct: 107 GRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIARRWI 161
Query: 578 DSRCLANLR------------PLLDSGTMGTKGHTEVIVPHLTESYNSHRD--PPEEEIP 623
+ ++ L PL+D GT G KG+ VI+P +T + PP+ P
Sbjct: 162 NGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFP 221
Query: 624 FCTLKSFPAAIEHTIQWAR 642
CT+ S P EH I++ R
Sbjct: 222 MCTIASMPRLPEHCIEYVR 240
Score = 40.0 bits (92), Expect = 0.012
Identities = 21/61 (34%), Positives = 33/61 (54%)
Query: 852 DDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIK 911
D D HI +I S RA Y+I T+ + +IIPA+A+T A ++ + A E+ K
Sbjct: 257 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 316
Query: 912 V 912
+
Sbjct: 317 I 317
Score = 38.1 bits (87), Expect = 0.044
Identities = 24/86 (27%), Positives = 40/86 (46%), Gaps = 5/86 (5%)
Query: 64 VFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVL 123
V + G GGLG E+ KNL L+G + + + D + +L F D+ R +AE
Sbjct: 58 VLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI--GRPKAEVAA 115
Query: 124 KHIAELNPYVHVTSSSVPFNETTDLS 149
+ + + P +V FN+ D +
Sbjct: 116 EFLNDRVPNCNVVPH---FNKIQDFN 138
>gi|38045942 ubiquitin-activating enzyme 3 isoform 1 [Homo sapiens]
Length = 463
Score = 117 bits (293), Expect = 6e-26
Identities = 70/199 (35%), Positives = 101/199 (50%), Gaps = 25/199 (12%)
Query: 458 LQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHI 517
L + ++G G +GCE+LKN AL G I V D D I+ SNLNRQFLFRP I
Sbjct: 67 LDTCKVLVIGAGGLGCELLKNLALSGFR------QIHVIDMDTIDVSNLNRQFLFRPKDI 120
Query: 518 QKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYV 577
+PK+ AA+ + H NK+ +ND FY + +I+ LD++ ARR++
Sbjct: 121 GRPKAEVAAEFLNDRVPNCNVVPHFNKI-----QDFNDTFYRQFHIIVCGLDSIIARRWI 175
Query: 578 DSRCLANLR------------PLLDSGTMGTKGHTEVIVPHLTESYNSHRD--PPEEEIP 623
+ ++ L PL+D GT G KG+ VI+P +T + PP+ P
Sbjct: 176 NGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFP 235
Query: 624 FCTLKSFPAAIEHTIQWAR 642
CT+ S P EH I++ R
Sbjct: 236 MCTIASMPRLPEHCIEYVR 254
Score = 40.0 bits (92), Expect = 0.012
Identities = 21/61 (34%), Positives = 33/61 (54%)
Query: 852 DDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTATVSGLVALEMIK 911
D D HI +I S RA Y+I T+ + +IIPA+A+T A ++ + A E+ K
Sbjct: 271 DGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFK 330
Query: 912 V 912
+
Sbjct: 331 I 331
Score = 38.1 bits (87), Expect = 0.044
Identities = 24/86 (27%), Positives = 40/86 (46%), Gaps = 5/86 (5%)
Query: 64 VFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVL 123
V + G GGLG E+ KNL L+G + + + D + +L F D+ R +AE
Sbjct: 72 VLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI--GRPKAEVAA 129
Query: 124 KHIAELNPYVHVTSSSVPFNETTDLS 149
+ + + P +V FN+ D +
Sbjct: 130 EFLNDRVPNCNVVPH---FNKIQDFN 152
>gi|225543288 SUMO1 activating enzyme subunit 1 isoform c [Homo
sapiens]
Length = 266
Score = 86.7 bits (213), Expect = 1e-16
Identities = 60/172 (34%), Positives = 85/172 (49%), Gaps = 5/172 (2%)
Query: 38 EIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQ 97
E + A Y RQ + G A +++ S V L G+ GLG EIAKNL+LAG+K +T+ D E+
Sbjct: 13 EEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVT 72
Query: 98 AWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCV 157
D G F + V RNRAEA L+ LNP V V + + + SF ++ V
Sbjct: 73 PEDPGAQFLIRTGSV--GRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE-SFFTQFDAV 129
Query: 158 VLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTT 209
LT + K++ C IKF + DV G F + G+ V + T
Sbjct: 130 CLTCCSRDVIVKVDQICHKN--SIKFFTGDVFGYHGYTFANLGEHEFVEEKT 179
Score = 39.3 bits (90), Expect = 0.020
Identities = 31/145 (21%), Positives = 59/145 (40%), Gaps = 11/145 (7%)
Query: 456 QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPH 515
++L+ + LVG +G E+ KN L GV KG +T+ D + + + QFL R
Sbjct: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGV-----KG-LTMLDHEQVTPEDPGAQFLIRTG 85
Query: 516 HIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARR 575
+ + ++ + + +N + + + E+ F+T+ D + + +
Sbjct: 86 SVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPES-----FFTQFDAVCLTCCSRDVIV 140
Query: 576 YVDSRCLANLRPLLDSGTMGTKGHT 600
VD C N G G+T
Sbjct: 141 KVDQICHKNSIKFFTGDVFGYHGYT 165
>gi|225543285 SUMO1 activating enzyme subunit 1 isoform b [Homo
sapiens]
Length = 299
Score = 86.7 bits (213), Expect = 1e-16
Identities = 60/172 (34%), Positives = 85/172 (49%), Gaps = 5/172 (2%)
Query: 38 EIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQ 97
E + A Y RQ + G A +++ S V L G+ GLG EIAKNL+LAG+K +T+ D E+
Sbjct: 13 EEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVT 72
Query: 98 AWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCV 157
D G F + V RNRAEA L+ LNP V V + + + SF ++ V
Sbjct: 73 PEDPGAQFLIRTGSV--GRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE-SFFTQFDAV 129
Query: 158 VLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTT 209
LT + K++ C IKF + DV G F + G+ V + T
Sbjct: 130 CLTCCSRDVIVKVDQICHKN--SIKFFTGDVFGYHGYTFANLGEHEFVEEKT 179
Score = 39.3 bits (90), Expect = 0.020
Identities = 31/145 (21%), Positives = 59/145 (40%), Gaps = 11/145 (7%)
Query: 456 QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPH 515
++L+ + LVG +G E+ KN L GV KG +T+ D + + + QFL R
Sbjct: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGV-----KG-LTMLDHEQVTPEDPGAQFLIRTG 85
Query: 516 HIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARR 575
+ + ++ + + +N + + + E+ F+T+ D + + +
Sbjct: 86 SVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPES-----FFTQFDAVCLTCCSRDVIV 140
Query: 576 YVDSRCLANLRPLLDSGTMGTKGHT 600
VD C N G G+T
Sbjct: 141 KVDQICHKNSIKFFTGDVFGYHGYT 165
>gi|4885585 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
Length = 346
Score = 86.7 bits (213), Expect = 1e-16
Identities = 60/172 (34%), Positives = 85/172 (49%), Gaps = 5/172 (2%)
Query: 38 EIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQ 97
E + A Y RQ + G A +++ S V L G+ GLG EIAKNL+LAG+K +T+ D E+
Sbjct: 13 EEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVT 72
Query: 98 AWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCV 157
D G F + V RNRAEA L+ LNP V V + + + SF ++ V
Sbjct: 73 PEDPGAQFLIRTGSV--GRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE-SFFTQFDAV 129
Query: 158 VLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTT 209
LT + K++ C IKF + DV G F + G+ V + T
Sbjct: 130 CLTCCSRDVIVKVDQICHKN--SIKFFTGDVFGYHGYTFANLGEHEFVEEKT 179
Score = 39.3 bits (90), Expect = 0.020
Identities = 31/145 (21%), Positives = 59/145 (40%), Gaps = 11/145 (7%)
Query: 456 QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPH 515
++L+ + LVG +G E+ KN L GV KG +T+ D + + + QFL R
Sbjct: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGV-----KG-LTMLDHEQVTPEDPGAQFLIRTG 85
Query: 516 HIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARR 575
+ + ++ + + +N + + + E+ F+T+ D + + +
Sbjct: 86 SVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPES-----FFTQFDAVCLTCCSRDVIV 140
Query: 576 YVDSRCLANLRPLLDSGTMGTKGHT 600
VD C N G G+T
Sbjct: 141 KVDQICHKNSIKFFTGDVFGYHGYT 165
Score = 39.3 bits (90), Expect = 0.020
Identities = 34/131 (25%), Positives = 67/131 (51%), Gaps = 15/131 (11%)
Query: 310 KCLIVDFSNPEAPLEI------HTAMLALDQFQEKYSRKPNVGC-QQDSEELLKLATSIS 362
+ L VD+S+ +A + + + L +F+ R P+ ++DSE LL++ +
Sbjct: 218 EALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVL 277
Query: 363 ETLEEKPDV-NADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLY--- 418
++L PD+ D V + ++P+ A VGG+ +QE++KA++ + P + +
Sbjct: 278 DSLGISPDLLPEDFVRYCF----SEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDG 333
Query: 419 LEAADIVESLG 429
++ IVE LG
Sbjct: 334 MKGNGIVECLG 344
>gi|7705473 SUMO1 activating enzyme subunit 1 isoform a [Homo
sapiens]
Length = 346
Score = 85.1 bits (209), Expect = 3e-16
Identities = 59/172 (34%), Positives = 84/172 (48%), Gaps = 5/172 (2%)
Query: 38 EIDDALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQ 97
E + A Y RQ + G A +++ S V L G+ GLG EIAKNL+LAG+K +T+ D E+
Sbjct: 13 EEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVT 72
Query: 98 AWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCV 157
D G F + V RNRAEA L+ LNP V V + + + SF ++ V
Sbjct: 73 PEDPGAQFLIRTGSV--GRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE-SFFTQFDAV 129
Query: 158 VLTEMKLPLQKKINDFCRSQCPPIKFISADVHGIWSRLFCDFGDEFEVLDTT 209
LT + K++ C IKF + D G F + G+ V + T
Sbjct: 130 CLTCCSRDVIVKVDQICHKN--SIKFFTGDAFGYHGYTFANLGEHEFVEEET 179
Score = 39.3 bits (90), Expect = 0.020
Identities = 31/145 (21%), Positives = 59/145 (40%), Gaps = 11/145 (7%)
Query: 456 QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPH 515
++L+ + LVG +G E+ KN L GV KG +T+ D + + + QFL R
Sbjct: 32 KRLRASRVLLVGLKGLGAEIAKNLILAGV-----KG-LTMLDHEQVTPEDPGAQFLIRTG 85
Query: 516 HIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARR 575
+ + ++ + + +N + + + E+ F+T+ D + + +
Sbjct: 86 SVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPES-----FFTQFDAVCLTCCSRDVIV 140
Query: 576 YVDSRCLANLRPLLDSGTMGTKGHT 600
VD C N G G+T
Sbjct: 141 KVDQICHKNSIKFFTGDAFGYHGYT 165
Score = 39.3 bits (90), Expect = 0.020
Identities = 34/131 (25%), Positives = 67/131 (51%), Gaps = 15/131 (11%)
Query: 310 KCLIVDFSNPEAPLEI------HTAMLALDQFQEKYSRKPNVGC-QQDSEELLKLATSIS 362
+ L VD+S+ +A + + + L +F+ R P+ ++DSE LL++ +
Sbjct: 218 EALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVL 277
Query: 363 ETLEEKPDV-NADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLY--- 418
++L PD+ D V + ++P+ A VGG+ +QE++KA++ + P + +
Sbjct: 278 DSLGISPDLLPEDFVRYCF----SEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDG 333
Query: 419 LEAADIVESLG 429
++ IVE LG
Sbjct: 334 MKGNGIVECLG 344
>gi|7657339 molybdenum cofactor synthesis 3 [Homo sapiens]
Length = 460
Score = 65.1 bits (157), Expect = 3e-10
Identities = 39/140 (27%), Positives = 68/140 (48%), Gaps = 10/140 (7%)
Query: 463 IFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKS 522
+ +VGCG +GC + + A GVG + + D D++E SNL RQ L + K+
Sbjct: 85 VLIVGCGGLGCPLAQYLAAAGVGR------LGLVDYDVVEMSNLARQVLHGEALAGQAKA 138
Query: 523 YTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCL 582
++AA + ++NS ++ + + P T + + DV+ DNV R V+ C+
Sbjct: 139 FSAAASLRRLNSAVECVPYTQALTPATAL----DLVRRYDVVADCSDNVPTRYLVNDACV 194
Query: 583 ANLRPLLDSGTMGTKGHTEV 602
RPL+ + + +G V
Sbjct: 195 LAGRPLVSASALRFEGQITV 214
Score = 40.8 bits (94), Expect = 0.007
Identities = 38/160 (23%), Positives = 67/160 (41%), Gaps = 5/160 (3%)
Query: 30 PIMSTASVEIDDAL-YSRQRYV--LGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIK 86
P+ A++ D+ L YSRQ + LG ++ + V + G GGLG +A+ L AG+
Sbjct: 48 PLPPKAALSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVG 107
Query: 87 AVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVHVTSSSVPFNETT 146
+ + D + + +L E + + +A + + LN V + T
Sbjct: 108 RLGLVDYDVVEMSNLARQVLHGE--ALAGQAKAFSAAASLRRLNSAVECVPYTQALTPAT 165
Query: 147 DLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPPIKFISA 186
L + +Y V +P + +ND C P+ SA
Sbjct: 166 ALDLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSASA 205
>gi|4502169 NEDD8 activating enzyme E1 subunit 1 isoform a [Homo
sapiens]
Length = 534
Score = 63.9 bits (154), Expect = 7e-10
Identities = 47/139 (33%), Positives = 64/139 (46%), Gaps = 5/139 (3%)
Query: 44 YSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGT 103
Y RQ + GD + + +HV L G EI KNLVL GI + TI D + D G
Sbjct: 13 YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGN 72
Query: 104 NFFLSEDDVVNKRNRAEAVLKHIAELNPYV--HVTSSSVPFNETTDLSFLDKYQCVVLTE 161
NFFL + +NRAEA ++ + ELN V S D SF ++ VV T+
Sbjct: 73 NFFLQRSSI--GKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQ 130
Query: 162 MKLPLQKKIND-FCRSQCP 179
+ ++ D SQ P
Sbjct: 131 LPESTSLRLADVLWNSQIP 149
Score = 48.1 bits (113), Expect = 4e-05
Identities = 52/219 (23%), Positives = 89/219 (40%), Gaps = 14/219 (6%)
Query: 437 LPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVT 496
L + +YD GD + L++ ++ L+ A G E+LKN L G+G+ T+
Sbjct: 7 LLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGS------FTII 60
Query: 497 DPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDE 556
D + + + F + I K ++ A + ++NS + + P +
Sbjct: 61 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSD--VSGSFVEESPENLLDNDPS 118
Query: 557 FYTKQDVII-TALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHR 615
F+ + V++ T L + R D + + PLL T G G+ +I+ SH
Sbjct: 119 FFCRFTVVVATQLPESTSLRLADVLWNSQI-PLLICRTYGLVGYMRIIIKE-HPVIESHP 176
Query: 616 DPPEEEIPFCTLKSFPAAIEHTIQWARDKFE-SSFSHKP 653
D E++ K FP EH + D E SH P
Sbjct: 177 DNALEDLRLD--KPFPELREHFQSYDLDHMEKKDHSHTP 213
Score = 48.1 bits (113), Expect = 4e-05
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Query: 312 LIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATSISETLEE---K 368
+I NP+ + ++ + A+D+F ++ R P V Q E++ KL + ++ L+E
Sbjct: 412 IISSMDNPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLS 471
Query: 369 PDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKF 410
V D VH +AA +GG A+QEV+K +T +F
Sbjct: 472 VMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQF 513
>gi|66363686 NEDD8 activating enzyme E1 subunit 1 isoform b [Homo
sapiens]
Length = 528
Score = 59.3 bits (142), Expect = 2e-08
Identities = 44/131 (33%), Positives = 60/131 (45%), Gaps = 5/131 (3%)
Query: 52 GDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDD 111
GD + + +HV L G EI KNLVL GI + TI D + D G NFFL
Sbjct: 15 GDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSS 74
Query: 112 VVNKRNRAEAVLKHIAELNPYV--HVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKK 169
+ +NRAEA ++ + ELN V S D SF ++ VV T++ +
Sbjct: 75 I--GKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLR 132
Query: 170 IND-FCRSQCP 179
+ D SQ P
Sbjct: 133 LADVLWNSQIP 143
Score = 48.1 bits (113), Expect = 4e-05
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Query: 312 LIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATSISETLEE---K 368
+I NP+ + ++ + A+D+F ++ R P V Q E++ KL + ++ L+E
Sbjct: 406 IISSMDNPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLS 465
Query: 369 PDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKF 410
V D VH +AA +GG A+QEV+K +T +F
Sbjct: 466 VMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQF 507
Score = 45.8 bits (107), Expect = 2e-04
Identities = 49/205 (23%), Positives = 84/205 (40%), Gaps = 14/205 (6%)
Query: 451 GDTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQF 510
GD + L++ ++ L+ A G E+LKN L G+G+ T+ D + + + F
Sbjct: 15 GDHGQEALESAHVCLINATATGTEILKNLVLPGIGS------FTIIDGNQVSGEDAGNNF 68
Query: 511 LFRPHHIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQDVII-TALD 569
+ I K ++ A + ++NS + + P + F+ + V++ T L
Sbjct: 69 FLQRSSIGKNRAEAAMEFLQELNSD--VSGSFVEESPENLLDNDPSFFCRFTVVVATQLP 126
Query: 570 NVEARRYVDSRCLANLRPLLDSGTMGTKGHTEVIVPHLTESYNSHRDPPEEEIPFCTLKS 629
+ R D + + PLL T G G+ +I+ SH D E++ K
Sbjct: 127 ESTSLRLADVLWNSQI-PLLICRTYGLVGYMRIIIKE-HPVIESHPDNALEDLRLD--KP 182
Query: 630 FPAAIEHTIQWARDKFE-SSFSHKP 653
FP EH + D E SH P
Sbjct: 183 FPELREHFQSYDLDHMEKKDHSHTP 207
>gi|38327032 ubiquitin-activating enzyme 5 isoform 2 [Homo sapiens]
Length = 348
Score = 51.6 bits (122), Expect = 4e-06
Identities = 37/164 (22%), Positives = 72/164 (43%), Gaps = 25/164 (15%)
Query: 456 QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPH 515
+K++ + +VG G +G + G+G + + D D +E +N+NR F F+PH
Sbjct: 13 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGK------LLLFDYDKVELANMNRLF-FQPH 65
Query: 516 HIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQ------------DV 563
K A IN + + H + T+ N + + + D+
Sbjct: 66 QAGLSKVQAAEHTLRNINPDVLFEVHNYNIT----TVENFQHFMDRISNGGLEEGKPVDL 121
Query: 564 IITALDNVEARRYVDSRCLANLRPLLDSGTM--GTKGHTEVIVP 605
+++ +DN EAR +++ C + ++SG GH ++I+P
Sbjct: 122 VLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIP 165
Score = 31.6 bits (70), Expect = 4.1
Identities = 19/70 (27%), Positives = 35/70 (50%)
Query: 57 QKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKR 116
+K+ V + G+GG+G A+ L GI + + D +K + ++ FF ++K
Sbjct: 13 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKV 72
Query: 117 NRAEAVLKHI 126
AE L++I
Sbjct: 73 QAAEHTLRNI 82
>gi|13376212 ubiquitin-activating enzyme 5 isoform 1 [Homo sapiens]
Length = 404
Score = 51.6 bits (122), Expect = 4e-06
Identities = 37/164 (22%), Positives = 72/164 (43%), Gaps = 25/164 (15%)
Query: 456 QKLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPH 515
+K++ + +VG G +G + G+G + + D D +E +N+NR F F+PH
Sbjct: 69 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGK------LLLFDYDKVELANMNRLF-FQPH 121
Query: 516 HIQKPKSYTAADATLKINSQIKIDAHLNKVCPTTETIYNDEFYTKQ------------DV 563
K A IN + + H + T+ N + + + D+
Sbjct: 122 QAGLSKVQAAEHTLRNINPDVLFEVHNYNIT----TVENFQHFMDRISNGGLEEGKPVDL 177
Query: 564 IITALDNVEARRYVDSRCLANLRPLLDSGTM--GTKGHTEVIVP 605
+++ +DN EAR +++ C + ++SG GH ++I+P
Sbjct: 178 VLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIP 221
Score = 31.6 bits (70), Expect = 4.1
Identities = 19/70 (27%), Positives = 35/70 (50%)
Query: 57 QKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKR 116
+K+ V + G+GG+G A+ L GI + + D +K + ++ FF ++K
Sbjct: 69 EKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKV 128
Query: 117 NRAEAVLKHI 126
AE L++I
Sbjct: 129 QAAEHTLRNI 138
>gi|66363688 NEDD8 activating enzyme E1 subunit 1 isoform c [Homo
sapiens]
Length = 445
Score = 48.1 bits (113), Expect = 4e-05
Identities = 30/102 (29%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Query: 312 LIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATSISETLEE---K 368
+I NP+ + ++ + A+D+F ++ R P V Q E++ KL + ++ L+E
Sbjct: 323 IISSMDNPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLS 382
Query: 369 PDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKF 410
V D VH +AA +GG A+QEV+K +T +F
Sbjct: 383 VMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQF 424
>gi|222144229 APG7 autophagy 7-like isoform c [Homo sapiens]
Length = 623
Score = 33.9 bits (76), Expect = 0.83
Identities = 42/157 (26%), Positives = 65/157 (41%), Gaps = 25/157 (15%)
Query: 457 KLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHH 516
K+ ++ L+G G +GC + + L+G G IT D I SN RQ L+
Sbjct: 313 KVVSVKCLLLGAGTLGCNVAR--TLMGWGVRH----ITFVDNAKISYSNPVRQPLYEFED 366
Query: 517 I---QKPKSYTAADATLKI---------NSQIKIDAH-LNKVCPTTETIYND-----EFY 558
KPK+ AAD KI N I + H +N T E D +
Sbjct: 367 CLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLI 426
Query: 559 TKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMG 595
DV+ +D E+ R++ + A+ R L+ + +G
Sbjct: 427 ESHDVVFLLMDTRES-RWLPAVIAASKRKLVINAALG 462
>gi|222144227 APG7 autophagy 7-like isoform b [Homo sapiens]
Length = 676
Score = 33.9 bits (76), Expect = 0.83
Identities = 42/157 (26%), Positives = 65/157 (41%), Gaps = 25/157 (15%)
Query: 457 KLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHH 516
K+ ++ L+G G +GC + + L+G G IT D I SN RQ L+
Sbjct: 352 KVVSVKCLLLGAGTLGCNVAR--TLMGWGVRH----ITFVDNAKISYSNPVRQPLYEFED 405
Query: 517 I---QKPKSYTAADATLKI---------NSQIKIDAH-LNKVCPTTETIYND-----EFY 558
KPK+ AAD KI N I + H +N T E D +
Sbjct: 406 CLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLI 465
Query: 559 TKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMG 595
DV+ +D E+ R++ + A+ R L+ + +G
Sbjct: 466 ESHDVVFLLMDTRES-RWLPAVIAASKRKLVINAALG 501
>gi|5453668 APG7 autophagy 7-like isoform a [Homo sapiens]
Length = 703
Score = 33.9 bits (76), Expect = 0.83
Identities = 42/157 (26%), Positives = 65/157 (41%), Gaps = 25/157 (15%)
Query: 457 KLQNLNIFLVGCGAIGCEMLKNFALLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHH 516
K+ ++ L+G G +GC + + L+G G IT D I SN RQ L+
Sbjct: 352 KVVSVKCLLLGAGTLGCNVAR--TLMGWGVRH----ITFVDNAKISYSNPVRQPLYEFED 405
Query: 517 I---QKPKSYTAADATLKI---------NSQIKIDAH-LNKVCPTTETIYND-----EFY 558
KPK+ AAD KI N I + H +N T E D +
Sbjct: 406 CLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLI 465
Query: 559 TKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMG 595
DV+ +D E+ R++ + A+ R L+ + +G
Sbjct: 466 ESHDVVFLLMDTRES-RWLPAVIAASKRKLVINAALG 501
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 33.9 bits (76), Expect = 0.83
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 6/66 (9%)
Query: 775 EEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILS 834
+E++S AL + E+K+ E K K+ +E ++ V IS E +++A LEK+I+
Sbjct: 32969 QEEISQKALRS--EEIKMSEAKSQEKLALKEEASK----VLISEEVKKSAATSLEKSIVH 33022
Query: 835 NEATKS 840
E TK+
Sbjct: 33023 EEITKT 33028
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 33.9 bits (76), Expect = 0.83
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 6/66 (9%)
Query: 775 EEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILS 834
+E++S AL + E+K+ E K K+ +E ++ V IS E +++A LEK+I+
Sbjct: 26664 QEEISQKALRS--EEIKMSEAKSQEKLALKEEASK----VLISEEVKKSAATSLEKSIVH 26717
Query: 835 NEATKS 840
E TK+
Sbjct: 26718 EEITKT 26723
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 33.9 bits (76), Expect = 0.83
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 6/66 (9%)
Query: 775 EEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILS 834
+E++S AL + E+K+ E K K+ +E ++ V IS E +++A LEK+I+
Sbjct: 26597 QEEISQKALRS--EEIKMSEAKSQEKLALKEEASK----VLISEEVKKSAATSLEKSIVH 26650
Query: 835 NEATKS 840
E TK+
Sbjct: 26651 EEITKT 26656
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 33.9 bits (76), Expect = 0.83
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 6/66 (9%)
Query: 775 EEDLSADALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILS 834
+E++S AL + E+K+ E K K+ +E ++ V IS E +++A LEK+I+
Sbjct: 26472 QEEISQKALRS--EEIKMSEAKSQEKLALKEEASK----VLISEEVKKSAATSLEKSIVH 26525
Query: 835 NEATKS 840
E TK+
Sbjct: 26526 EEITKT 26531
>gi|50811873 suppressor of hairy wing homolog 4 isoform 2 [Homo
sapiens]
Length = 966
Score = 32.3 bits (72), Expect = 2.4
Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 21/120 (17%)
Query: 616 DPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPS----------LFNKFWQTYSS 665
DP + + +C P I + + A+ +F S+ + + L N F+ Y
Sbjct: 240 DPLKNHMKYCC----PDMINNFLGLAKTEFSSTVNKNTTIDSEKGKLIMLVNDFY--YGK 293
Query: 666 AEEVLQKIQSGHSLEGCFQVIKLLSRRPR---NWSQCVELARLKFEKYFNHKALQLLHCF 722
E +Q+ Q H+ CF +K+L R + +EL + E + NH Q HC+
Sbjct: 294 HEGDVQEEQKTHTTFKCFSCLKILKNNIRFMNHMKHHLELEKQSSESWENHTTCQ--HCY 351
>gi|50811871 suppressor of hairy wing homolog 4 isoform 1 [Homo
sapiens]
Length = 979
Score = 32.3 bits (72), Expect = 2.4
Identities = 29/120 (24%), Positives = 50/120 (41%), Gaps = 21/120 (17%)
Query: 616 DPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPS----------LFNKFWQTYSS 665
DP + + +C P I + + A+ +F S+ + + L N F+ Y
Sbjct: 253 DPLKNHMKYCC----PDMINNFLGLAKTEFSSTVNKNTTIDSEKGKLIMLVNDFY--YGK 306
Query: 666 AEEVLQKIQSGHSLEGCFQVIKLLSRRPR---NWSQCVELARLKFEKYFNHKALQLLHCF 722
E +Q+ Q H+ CF +K+L R + +EL + E + NH Q HC+
Sbjct: 307 HEGDVQEEQKTHTTFKCFSCLKILKNNIRFMNHMKHHLELEKQSSESWENHTTCQ--HCY 364
>gi|98986445 carcinoembryonic antigen-related cell adhesion molecule
5 preproprotein [Homo sapiens]
Length = 702
Score = 31.2 bits (69), Expect = 5.4
Identities = 12/25 (48%), Positives = 18/25 (72%)
Query: 211 EEPKEIFISNITQANPGIVTCLENH 235
+ +E+FISNIT+ N G+ TC N+
Sbjct: 457 QHTQELFISNITEKNSGLYTCQANN 481
>gi|41872631 fatty acid synthase [Homo sapiens]
Length = 2511
Score = 30.4 bits (67), Expect = 9.2
Identities = 11/30 (36%), Positives = 21/30 (70%)
Query: 61 KSHVFLSGMGGLGLEIAKNLVLAGIKAVTI 90
KS++ G+GG GLE+A+ L+ G++ + +
Sbjct: 1885 KSYIIAGGLGGFGLELAQWLIQRGVQKLVL 1914
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,342,882
Number of Sequences: 37866
Number of extensions: 1771368
Number of successful extensions: 4068
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 3927
Number of HSP's gapped (non-prelim): 76
length of query: 1052
length of database: 18,247,518
effective HSP length: 113
effective length of query: 939
effective length of database: 13,968,660
effective search space: 13116571740
effective search space used: 13116571740
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.