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Search of human proteins with 110347425
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110347425 structural maintenance of chromosomes 2 [Homo
sapiens]
(1197 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 2311 0.0
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 2311 0.0
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 2311 0.0
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 316 7e-86
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 283 7e-76
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 232 1e-60
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 232 1e-60
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 201 3e-51
gi|118498356 kinectin 1 isoform a [Homo sapiens] 112 2e-24
gi|33620775 kinectin 1 isoform a [Homo sapiens] 112 2e-24
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 111 4e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 107 5e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 107 5e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 107 5e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 107 5e-23
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 107 7e-23
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 106 2e-22
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 106 2e-22
gi|118498362 kinectin 1 isoform b [Homo sapiens] 105 3e-22
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 105 3e-22
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 105 3e-22
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 104 4e-22
gi|156104908 myosin heavy chain 6 [Homo sapiens] 104 4e-22
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 103 7e-22
gi|71061468 centromere protein E [Homo sapiens] 103 7e-22
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 103 7e-22
gi|118498368 kinectin 1 isoform c [Homo sapiens] 103 1e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 103 1e-21
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 103 1e-21
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 102 2e-21
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 2311 bits (5990), Expect = 0.0
Identities = 1197/1197 (100%), Positives = 1197/1197 (100%)
Query: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS
Sbjct: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
Query: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV
Sbjct: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
Query: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL
Sbjct: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
Query: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE
Sbjct: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
Query: 301 DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH
Sbjct: 301 DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
Query: 361 ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ
Sbjct: 361 ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
Query: 421 MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE
Sbjct: 421 MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
Query: 481 KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA
Sbjct: 481 KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
Query: 541 LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP
Sbjct: 541 LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
Query: 601 DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH
Sbjct: 601 DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
Query: 661 GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE
Sbjct: 661 GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
Query: 721 MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM
Sbjct: 721 MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL
Sbjct: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
Query: 841 EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK
Sbjct: 841 EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
Query: 901 EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN
Sbjct: 901 EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
Query: 961 NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE
Sbjct: 961 NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
Query: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE
Sbjct: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
Query: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF
Sbjct: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
Query: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV
Sbjct: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 2311 bits (5990), Expect = 0.0
Identities = 1197/1197 (100%), Positives = 1197/1197 (100%)
Query: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS
Sbjct: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
Query: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV
Sbjct: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
Query: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL
Sbjct: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
Query: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE
Sbjct: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
Query: 301 DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH
Sbjct: 301 DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
Query: 361 ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ
Sbjct: 361 ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
Query: 421 MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE
Sbjct: 421 MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
Query: 481 KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA
Sbjct: 481 KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
Query: 541 LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP
Sbjct: 541 LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
Query: 601 DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH
Sbjct: 601 DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
Query: 661 GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE
Sbjct: 661 GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
Query: 721 MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM
Sbjct: 721 MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL
Sbjct: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
Query: 841 EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK
Sbjct: 841 EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
Query: 901 EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN
Sbjct: 901 EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
Query: 961 NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE
Sbjct: 961 NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
Query: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE
Sbjct: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
Query: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF
Sbjct: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
Query: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV
Sbjct: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 2311 bits (5990), Expect = 0.0
Identities = 1197/1197 (100%), Positives = 1197/1197 (100%)
Query: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS
Sbjct: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
Query: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV
Sbjct: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
Query: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA
Sbjct: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA 180
Query: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL
Sbjct: 181 AQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
Query: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE
Sbjct: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
Query: 301 DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH
Sbjct: 301 DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
Query: 361 ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ
Sbjct: 361 ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
Query: 421 MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE
Sbjct: 421 MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
Query: 481 KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA
Sbjct: 481 KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTA 540
Query: 541 LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP
Sbjct: 541 LELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
Query: 601 DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH
Sbjct: 601 DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
Query: 661 GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE
Sbjct: 661 GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
Query: 721 MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM
Sbjct: 721 MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL
Sbjct: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQL 840
Query: 841 EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK
Sbjct: 841 EAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
Query: 901 EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN
Sbjct: 901 EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTN 960
Query: 961 NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE
Sbjct: 961 NPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
Query: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE
Sbjct: 1021 DLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKE 1080
Query: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF
Sbjct: 1081 NLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF 1140
Query: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV
Sbjct: 1141 IVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV 1197
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 316 bits (810), Expect = 7e-86
Identities = 303/1276 (23%), Positives = 585/1276 (45%), Gaps = 186/1276 (14%)
Query: 1 MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRAS 60
M+IK +I++GF+SY +T V+ F N I G NGSGKSN +I F+L S +R
Sbjct: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLS-DEFSHLRPE 59
Query: 61 NLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
L+++ + A V I FDNSD + + E R+V+ +++Y ++
Sbjct: 60 QRLALLHEGTGPRVISAFVEIIFDNSDNR-----LPIDKEEVSLRRVIGAKKDQYFLDKK 114
Query: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKK-- 178
V +L S G + +NP++++ QG+I ++ + L ++ E AGTR+Y+ +K
Sbjct: 115 MVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEE 174
Query: 179 -IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEH------LS 231
I+ K E K K+ E+ +EE + T+++ KEE + Y ++ K+ R +E+ L+
Sbjct: 175 SISLMKETEGKREKINELLKYIEERLH-TLEEEKEELAQYQKWDKMRRALEYTIYNQELN 233
Query: 232 RLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKE 291
L A+ + S E+ ++++D ++++ + +++++ L +I +++ K++
Sbjct: 234 ETRAKLDELSAK--RETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQ- 290
Query: 292 TGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAK--- 348
L+ ++ K ++ +LK K+L E + E K ++++ + L K
Sbjct: 291 -----------LSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEE 339
Query: 349 -EKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAG------LSSNE---------- 391
+KE+ + ++++E + LA A Q + A +S E
Sbjct: 340 KQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKEL 399
Query: 392 ---DGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQ 448
D A Q+ A D+ + ++ + Q+L +A V+++D Y +
Sbjct: 400 KSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYE-- 457
Query: 449 EALEAVKRLKEKLEAEMKKLNYEENKEESLL-------EKRRQLSRDIGRLKETYEALLA 501
VK K++L++E L EEN E+ L EK++QL R T +A+L
Sbjct: 458 -----VKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLR-----AATGKAILN 507
Query: 502 RFPNLRFAYKD-PEKNWNRNCVKGLVASLISVKDTSAT--TALELVAGERLYNVVVDTEV 558
++ K N++ G +++ + T +E+ AG RL+ +VD++
Sbjct: 508 GIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDE 567
Query: 559 TGKKLL---ERGELKRRYTIIPLNKISARCIA-PETLRVAQNLVGPDNVHVALSLVEYKP 614
K+L + L T +PLNK+ R A PET ++ +S + Y P
Sbjct: 568 VSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPET----------NDAIPMISKLRYNP 617
Query: 615 ELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
KA + VFG T +C +M+ + ++A + +TL GD G L+GG S
Sbjct: 618 RFDKAFKHVFGKTLICRSMEVSTQLA--RAFTMDCITLEGDQVSHRGALTGGYYDTRKSR 675
Query: 675 LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ 734
L ++Q ++R E EL LE +L L++ E E D L ++Q
Sbjct: 676 L-------ELQKDVRKAEEELGELEAKLN---------ENLRRNIERINNEIDQLMNQMQ 719
Query: 735 QSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDA 794
Q QQ + A + +I +K KE ++++E+ + + +++ EA ++
Sbjct: 720 Q--IETQQRKFKASRDSILSE---MKMLKEKRQQSEKTFMPKQRSLQSLEASLHA-MEST 773
Query: 795 QKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQI 854
++ L A+ D S+ E Q+ V+A+ E+ +L++E+ + +NE IK E I
Sbjct: 774 RESLK-AELGTDLLSQLSLEDQKRVDALNDEIRQLQQENR------QLLNERIK-LEGII 825
Query: 855 EVMAAEVAKN-KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL 913
+ + +N ++ +++ ++E+ + +E T TV+ A +E+ ++ D+ + ++L
Sbjct: 826 TRVETYLNENLRKRLDQVEQELNELRE--TEGGTVLTATTSELEAINKRVKDTMARSEDL 883
Query: 914 DHNISKHK---REAEDGAAKVSKMLKDY-DWINAE------------------------- 944
D++I K + +E + + M K++ D IN +
Sbjct: 884 DNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKI 943
Query: 945 RHLFGQPNSAYD-FKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMK 1003
R L P A++ ++T + K+ ++L++ +K +VN +A++ E+ L+K
Sbjct: 944 RELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYS-HVNKKALDQFVNFSEQKEKLIK 1002
Query: 1004 KKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQT 1063
++ ++ I+ + L+ +K +A+ + +++V+K+F +F L+PG A L +G
Sbjct: 1003 RQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDV 1062
Query: 1064 V-----------------------------LDGLEFKVALGNTWKE--NLTELSGGQRSL 1092
G+ +V+ E + +LSGGQ+SL
Sbjct: 1063 EGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSL 1122
Query: 1093 VALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNN 1152
VAL+LI ++ PAP Y+ DE+D ALD H + + M+ H+QFI + + + +
Sbjct: 1123 VALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLES 1182
Query: 1153 ANVLFKTKFVDGVSTV 1168
A+ + KF + VS +
Sbjct: 1183 ADKFYGVKFRNKVSHI 1198
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 283 bits (724), Expect = 7e-76
Identities = 316/1265 (24%), Positives = 570/1265 (45%), Gaps = 179/1265 (14%)
Query: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
+K I +E FKSY R + F F AI G NGSGKSN++D+I F+LG S +R L
Sbjct: 4 LKLIEIENFKSYKGRQIIGPFQR-FTAIIGPNGSGKSNLMDAISFVLG-EKTSNLRVKTL 61
Query: 63 QDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGV 120
+DL++ G+ +A VS+ + E ++ T R V++GG ++Y IN
Sbjct: 62 RDLIHGAPVGKPAANRAFVSMVYSE----------EGAEDRTFAR-VIVGGSSEYKINNK 110
Query: 121 NANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAA--GTRMYEYKK 178
+ +G+ + +FL+ QG + + P E ++ EE + G EY K
Sbjct: 111 VVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDK 170
Query: 179 -----IAAQKTIE-----KKEAKLKEIKTILEEEITPTIQKLKEE---RSSYLEYQKVMR 225
+ A++ + KK + + E+E Q+LK+E L+ K+
Sbjct: 171 RKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYH 230
Query: 226 ---EIEHLSRLYIAYQFLLAEDTKV--RSAEELKEMQDKVIKLQEELSENDKKIKALNHE 280
EIE L++ + + +D K + +ELKE + ++ K+ E + +K+IK + E
Sbjct: 231 NEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSE 290
Query: 281 IEELEKR--KDKE-TGGILRSLEDA---LAEAQRVNTKSQSAFDLKKKNLACEESKRKEL 334
+ + + K KE T ++ LE A L AQ+ K + D +K + E R+E
Sbjct: 291 LNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEF 350
Query: 335 EKNMVEDSKT----LAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSN 390
E+ M E+S++ L +E +VKK H L+E ++K A LA + FN
Sbjct: 351 EERMEEESQSQGRDLTLEENQVKKY----HRLKEEASKRAATLAQELEKFNRDQKADQDR 406
Query: 391 EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
D E K +TEAK +K +E++ Q ++K++ +++
Sbjct: 407 LDLEER-------------KKVETEAK-----IKQKLREIEENQKRIEKLEEYITTSKQS 448
Query: 451 LEAVKRLKEKL--EAEMKKLNYEE-NKE-----ESLLEKR--RQLSRDIGRLKETYEALL 500
LE K+L+ +L E EM K +E NKE E L + R RQ S R E E++
Sbjct: 449 LEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK 508
Query: 501 ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
+P V G + L A+ V G+ + ++VD+E TG
Sbjct: 509 RLYPG---------------SVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTG 553
Query: 561 KKLLE-----RGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKP- 614
+ ++ RGE + T +PL+ + + E LR + + + ++ Y+P
Sbjct: 554 RDCIQYIKEQRGEPE---TFLPLDYLEVKP-TDEKLRELKG------AKLVIDVIRYEPP 603
Query: 615 ELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
++KA+++ G VCDN+++A+++AF +TV L G +F G +SGGA A
Sbjct: 604 HIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKA 663
Query: 675 LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ--------QWEMKTEEA 726
++ D ++KE + R L EEL K +L+Q Q +K ++
Sbjct: 664 RRWDEKAVD-----KLKEKKER-LTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQS 717
Query: 727 DLLQTKLQQSSYHKQQEE------------LDALKKTIEESEETLKNTKEIQRKAEEKY- 773
DL QTK + + + Q++ ++ +K+ I+ E +K+ KE + E++
Sbjct: 718 DLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVF 777
Query: 774 -----EVLENKMKNAEAER-ERELKDAQKKLDCAKTKA------DASSKKMKEKQ----- 816
E+ ++ E E+ +R+ + A+K+L+ K D ++KE Q
Sbjct: 778 EEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHM 837
Query: 817 --QEVEAITLELEELKREHTSYKQ-------QLEAVNEAIKSYESQIEVMAAEVAKNKES 867
Q V+ E+E+LK+E + + QL+ + + +S++ E+ + ++
Sbjct: 838 WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKK 897
Query: 868 VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKI---KELDHNISKHKREA 924
+ A +E+T ++ +TA +T ++ K ++ + +K+ K +IS+ + +
Sbjct: 898 LGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSS 957
Query: 925 E-----DGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
+ G+ ++S + I + + + +E QKL E + L
Sbjct: 958 QGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVL 1017
Query: 980 GRNV--NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKV 1037
R NM+AM L +++ + + K E + +++ N ++ V
Sbjct: 1018 QRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESV 1077
Query: 1038 NKDFGSIFSTLL--PGANAMLAP--PEGQTVLDGLEFK-VALGNTWKENLTELSGGQRSL 1092
+ I+ L A A L P PE + LDG+ + VA G ++ + LSGG++++
Sbjct: 1078 ATNIDEIYKALSRNSSAQAFLGPENPE-EPYLDGINYNCVAPGKRFRP-MDNLSGGEKTV 1135
Query: 1093 VALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFT-HSQFIVVSLKEGMFN 1151
AL+L+ ++ +KPAP ++LDE+DAALD ++ + ++ T + Q IV+SLKE +
Sbjct: 1136 AALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYT 1195
Query: 1152 NANVL 1156
A L
Sbjct: 1196 KAESL 1200
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 232 bits (592), Expect = 1e-60
Identities = 288/1240 (23%), Positives = 536/1240 (43%), Gaps = 159/1240 (12%)
Query: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
I I+ + FKSYA + F F+ I G NGSGKSN++DS+ F+ G ++R+ L
Sbjct: 84 ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKL 142
Query: 63 QDLVYKNGQ-AGITKASVSITFDNSDKKQSPLGFEV--HDEITVTRQVVIGGRNKYLING 119
L++ + + I +V + F K+ +EV + V+R + Y I+G
Sbjct: 143 SVLIHNSDEHKDIQSCTVEVHFQKIIDKEGD-DYEVIPNSNFYVSRTACRDNTSVYHISG 201
Query: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE-------ILSMIEEAAGT- 171
V +L S G+++++ FLI+QG + ++ MKP +L +E+ G
Sbjct: 202 KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261
Query: 172 RMYEYKKIAAQKTI---EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVM 224
R+ E K+ ++ E + KL +K + +E+ L+ E++ +E+ ++
Sbjct: 262 RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEK-----DALEGEKNIAIEFLTLENEIF 316
Query: 225 REIEHLSRLYI---AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK----AL 277
R+ H+ + YI + E K + E+ KE+ +K L E+ +K +K L
Sbjct: 317 RKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
Query: 278 NHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKN 337
N + +E+ K+K T LED +V K + A KK E+ +K+ EK
Sbjct: 377 NKITKFIEENKEKFTQ---LDLEDV-----QVREKLKHATSKAKK---LEKQLQKDKEK- 424
Query: 338 MVEDSKTLAAKEKEV-KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
VE+ K++ AK + + T +AL++ K+ + L + GL ++ E
Sbjct: 425 -VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK 483
Query: 397 TLAGQMMACKNDISK-----------------AQTEAKQAQMKLKHAQQELKNKQAEVKK 439
L G + SK A ++ +A+ L A + LK ++A ++
Sbjct: 484 ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRD 543
Query: 440 MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ----------LSRDI 489
++ + ++ LKEK E E++KL EE +SL+ Q ++R
Sbjct: 544 IEGKLPQTEQ------ELKEK-EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596
Query: 490 GRLKETY--EALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
G++ + E R P + + R G + V +S AL+ + +
Sbjct: 597 GKVLDAIIQEKKSGRIPGI----------YGRLGDLGAIDEKYDVAISSCCHALDYIVVD 646
Query: 548 RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
+D L+R + T I L+K++ + + P+N
Sbjct: 647 S-----IDIAQECVNFLKRQNIGVA-TFIGLDKMAVWA------KKMTEIQTPENTPRLF 694
Query: 608 SLVEYKPE-LQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
LV+ K E +++A F T V DN+D A +VA+ K R VTL G + + GT++GG
Sbjct: 695 DLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGG 754
Query: 667 ARS-----QAASILTKF--QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQW 719
+S++ + +E+ ++ +L+ + ++E+ L+ K R +++
Sbjct: 755 GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814
Query: 720 EMKTEEADL-LQTKLQQSSY-HKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
E+ +Q ++Q Y + Q +EL+A ++ K +E + +Y+ +
Sbjct: 815 RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874
Query: 778 NKMKNAEAERER-----------ELKDAQKKLD--------CAK--TKADASSKKMKEKQ 816
K EAE +R +LK Q KLD CA TKA + K
Sbjct: 875 EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
Query: 817 QEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVT 876
Q+ + L E +E +++++ + +KS E + AAEV KN + ++ E+
Sbjct: 935 QKAQDSVLRTE---KEIKDTEKEVDDLTAELKSLEDK----AAEVVKNTNAAEESLPEIQ 987
Query: 877 KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM-L 935
K+ + + VI+ E A K+ + +LK++++D +I++H + + ++SK+ L
Sbjct: 988 KEHRNLLQELKVIQEN--EHALQKDALS-IKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044
Query: 936 KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ----EMKEKLGRNVNMRAMNVL 991
+ E P K NP ++ L+ EMK LG A+
Sbjct: 1045 HPIEDNPIEEISVLSPEDLEAIK--NPDSITNQIALLEARCHEMKPNLG------AIAEY 1096
Query: 992 TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPG 1051
+ EE Y + + + ++ EDL +++ + + + L G
Sbjct: 1097 KKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLG 1156
Query: 1052 ANAMLAPPEG-QTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIY 1110
+A L + +G+ F V + + LSGG+++L +L+L+ ++ +KP P+Y
Sbjct: 1157 GDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216
Query: 1111 ILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMF 1150
+DE+DAALD + + + ++QFI++SL+ MF
Sbjct: 1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1256
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 232 bits (592), Expect = 1e-60
Identities = 288/1240 (23%), Positives = 536/1240 (43%), Gaps = 159/1240 (12%)
Query: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
I I+ + FKSYA + F F+ I G NGSGKSN++DS+ F+ G ++R+ L
Sbjct: 84 ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKL 142
Query: 63 QDLVYKNGQ-AGITKASVSITFDNSDKKQSPLGFEV--HDEITVTRQVVIGGRNKYLING 119
L++ + + I +V + F K+ +EV + V+R + Y I+G
Sbjct: 143 SVLIHNSDEHKDIQSCTVEVHFQKIIDKEGD-DYEVIPNSNFYVSRTACRDNTSVYHISG 201
Query: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE-------ILSMIEEAAGT- 171
V +L S G+++++ FLI+QG + ++ MKP +L +E+ G
Sbjct: 202 KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261
Query: 172 RMYEYKKIAAQKTI---EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVM 224
R+ E K+ ++ E + KL +K + +E+ L+ E++ +E+ ++
Sbjct: 262 RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEK-----DALEGEKNIAIEFLTLENEIF 316
Query: 225 REIEHLSRLYI---AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK----AL 277
R+ H+ + YI + E K + E+ KE+ +K L E+ +K +K L
Sbjct: 317 RKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
Query: 278 NHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKN 337
N + +E+ K+K T LED +V K + A KK E+ +K+ EK
Sbjct: 377 NKITKFIEENKEKFTQ---LDLEDV-----QVREKLKHATSKAKK---LEKQLQKDKEK- 424
Query: 338 MVEDSKTLAAKEKEV-KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
VE+ K++ AK + + T +AL++ K+ + L + GL ++ E
Sbjct: 425 -VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK 483
Query: 397 TLAGQMMACKNDISK-----------------AQTEAKQAQMKLKHAQQELKNKQAEVKK 439
L G + SK A ++ +A+ L A + LK ++A ++
Sbjct: 484 ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRD 543
Query: 440 MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ----------LSRDI 489
++ + ++ LKEK E E++KL EE +SL+ Q ++R
Sbjct: 544 IEGKLPQTEQ------ELKEK-EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596
Query: 490 GRLKETY--EALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
G++ + E R P + + R G + V +S AL+ + +
Sbjct: 597 GKVLDAIIQEKKSGRIPGI----------YGRLGDLGAIDEKYDVAISSCCHALDYIVVD 646
Query: 548 RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
+D L+R + T I L+K++ + + P+N
Sbjct: 647 S-----IDIAQECVNFLKRQNIGVA-TFIGLDKMAVWA------KKMTEIQTPENTPRLF 694
Query: 608 SLVEYKPE-LQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
LV+ K E +++A F T V DN+D A +VA+ K R VTL G + + GT++GG
Sbjct: 695 DLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGG 754
Query: 667 ARS-----QAASILTKF--QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQW 719
+S++ + +E+ ++ +L+ + ++E+ L+ K R +++
Sbjct: 755 GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814
Query: 720 EMKTEEADL-LQTKLQQSSY-HKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
E+ +Q ++Q Y + Q +EL+A ++ K +E + +Y+ +
Sbjct: 815 RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874
Query: 778 NKMKNAEAERER-----------ELKDAQKKLD--------CAK--TKADASSKKMKEKQ 816
K EAE +R +LK Q KLD CA TKA + K
Sbjct: 875 EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
Query: 817 QEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVT 876
Q+ + L E +E +++++ + +KS E + AAEV KN + ++ E+
Sbjct: 935 QKAQDSVLRTE---KEIKDTEKEVDDLTAELKSLEDK----AAEVVKNTNAAEESLPEIQ 987
Query: 877 KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM-L 935
K+ + + VI+ E A K+ + +LK++++D +I++H + + ++SK+ L
Sbjct: 988 KEHRNLLQELKVIQEN--EHALQKDALS-IKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044
Query: 936 KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ----EMKEKLGRNVNMRAMNVL 991
+ E P K NP ++ L+ EMK LG A+
Sbjct: 1045 HPIEDNPIEEISVLSPEDLEAIK--NPDSITNQIALLEARCHEMKPNLG------AIAEY 1096
Query: 992 TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPG 1051
+ EE Y + + + ++ EDL +++ + + + L G
Sbjct: 1097 KKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLG 1156
Query: 1052 ANAMLAPPEG-QTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIY 1110
+A L + +G+ F V + + LSGG+++L +L+L+ ++ +KP P+Y
Sbjct: 1157 GDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216
Query: 1111 ILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMF 1150
+DE+DAALD + + + ++QFI++SL+ MF
Sbjct: 1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1256
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 [Homo
sapiens]
Length = 1235
Score = 201 bits (512), Expect = 3e-51
Identities = 281/1267 (22%), Positives = 526/1267 (41%), Gaps = 185/1267 (14%)
Query: 2 HIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASN 61
H++ +++E FKS+ R + F F I G NGSGKSN++D++ F++G ++ +R N
Sbjct: 3 HLELLLVENFKSWRGRQVIGPFRR-FTCIIGPNGSGKSNVMDALSFVMG-EKIANLRVKN 60
Query: 62 LQDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLING 119
+Q+L++ G+ + ASV I + E +E T R ++ GG +++ N
Sbjct: 61 IQELIHGAHIGKPISSSASVKIIYVE----------ESGEEKTFAR-IIRGGCSEFRFND 109
Query: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRM----YE 175
+ + +G+ V + L+ QG + + KP E EE + + YE
Sbjct: 110 NLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYE 169
Query: 176 YKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI 235
KK QK E + + K I E ++K + ER YQ ++ E++ ++++ +
Sbjct: 170 EKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAER-----YQSLLEELK-MNKIQL 223
Query: 236 AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
L + K+ E ++ + ++ E +L+H E + K + KE G +
Sbjct: 224 QLFQLYHNEKKIHLLNTKLEHVNRDLSVKRE---------SLSHH-ENIVKARKKEHGML 273
Query: 296 LRSLEDALAEAQRVNT--KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
R L+ E + V T + +K K K+ ++ K ++DS EK+
Sbjct: 274 TRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDS------EKQCS 327
Query: 354 KITDGLHALQ-EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEATLAGQMMACKNDISK 411
K D + AL+ E ++ DA + +Q + L D EA+ + K + K
Sbjct: 328 KQEDDIKALETELADLDAAWRSFEKQIEEEI---LHKKRDIELEASQLDRYKELKEQVRK 384
Query: 412 AQTEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKK 467
Q KL+ Q+ + + A K+ + ++ +E +E K+ EKLE K
Sbjct: 385 KVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKT 444
Query: 468 ----LNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR---- 519
L ++ +EE+L+++ + + E + + N + ++ R
Sbjct: 445 CMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVL 504
Query: 520 --------NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLE--RGEL 569
+ V G + L A+ V G + +VV +E K + + E
Sbjct: 505 EHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEER 564
Query: 570 KRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK-PELQKAMEFVFGTTF 628
T + L+ + + I E LR + + + +++ + P+L+K ++FV G
Sbjct: 565 AEPETFLALDYLDIKPIN-ERLRELKGC------KMVIDVIKTQFPQLKKVIQFVCGNGL 617
Query: 629 VCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARS-QAASILTKFQELKDVQDE 687
VC+ M+ A+ +A +TV L G +F G +SGG+ + + +ELK+++D
Sbjct: 618 VCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDR 677
Query: 688 LRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHKQQEEL 745
K EL+ GL T K LKQ +QT +Q Q+ Q EL
Sbjct: 678 RSQKIQELK-------GLMKTLRKETDLKQ-----------IQTLIQGTQTRLKYSQNEL 719
Query: 746 DALKKT--IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLD---- 799
+ +KK + +E + E+ E + +L +K ER+R +K+ Q+K+D
Sbjct: 720 EMIKKKHLVAFYQEQSQLQSELLN-IESQCIMLSEGIK----ERQRRIKEFQEKIDKVED 774
Query: 800 ------CAKTKAD---ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSY 850
C + + K ++QQE++ LE E+ K T QLE +K
Sbjct: 775 DIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQK---TRLNVQLEYSRSHLKKK 831
Query: 851 ESQIEVMAAEVAKNKESVN---KAQEEVTKQKEVITAQDTVIK----AKYAEVAKHKEQN 903
++I + + K E ++ KA+E + + A+ +K + + K + Q
Sbjct: 832 LNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQI 891
Query: 904 NDSQLKIKELDHNISKHKREA-------EDGAAKVSKMLKDYDWINAERHLFG------- 949
+ + K +D + K ++E E + +L D + E L
Sbjct: 892 EEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951
Query: 950 ------------------QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV-------- 983
+ A++ ++ KE + LQ QE++ L +
Sbjct: 952 EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
Query: 984 --------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ 1035
N+RA+ L +++ + + E + +++ ++
Sbjct: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
Query: 1036 KVNKDFGSIFSTLLPG--ANAMLAP--PEGQTVLDGLEFKVALGNTWKENLTELSGGQRS 1091
V+ I+ L A A L+P PE + L+G+ + + LSGG++
Sbjct: 1072 HVSISIDQIYKKLCRNNSAQAFLSPENPE-EPYLEGISYNCVAPGKRFMPMDNLSGGEKC 1130
Query: 1092 LVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF--IVVSLKEGM 1149
+ AL+L+ ++ F+PAP ++LDEVDAALD ++ + ++ T QF IV+SLKE
Sbjct: 1131 VAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQ-TQDQFQMIVISLKEEF 1189
Query: 1150 FNNANVL 1156
++ A+ L
Sbjct: 1190 YSRADAL 1196
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 112 bits (280), Expect = 2e-24
Identities = 199/948 (20%), Positives = 390/948 (41%), Gaps = 122/948 (12%)
Query: 171 TRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL-----EYQKVMR 225
T+ + K ++ +E + A LK+ IL + ++ T +L+ ++S+ L +Y +++
Sbjct: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460
Query: 226 EI-EHLSRLYIA-YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEE 283
E+ E +L Q AE + +L+E + + ++Q + + + +A +++
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
Query: 284 LEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKE----LEKNMV 339
K+ E + L D L Q++ + + ++K + EES + + LE+N
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEA 580
Query: 340 -----------------------EDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAA 376
E K +A K+K++K+ D L + ++ E L
Sbjct: 581 LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDI 640
Query: 377 QQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLK----HAQQELKN 432
Q + A + + LA + A +++ K Q K++ Q E+ N
Sbjct: 641 QNMNFLLKAEVQKLQ-----ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695
Query: 433 KQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRL 492
K E K ++ +AL++ + + L +E + E E+ + EK +L
Sbjct: 696 KMEEFKILND----QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL------- 744
Query: 493 KETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASL--ISVKDTSATTALELVAGERLY 550
+T E LL ++ A K+ E N R L + + K + LV E L
Sbjct: 745 -KTVEELLET-GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV--EELK 800
Query: 551 NVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVA--LS 608
V+ + + K+ EL + NK + ++ + +G + A LS
Sbjct: 801 KVIHEKD---GKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS 857
Query: 609 LVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTLGGDVFDPHGTLSGGA 667
+ ELQ ++ G + M+ K V +K + + T D+ + + +L
Sbjct: 858 ITSKVQELQNLLK---GKE---EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
Query: 668 RSQA------ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE- 720
+ A AS ++F+EL+ V L+ KENEL+ LE L ++ QL Q +
Sbjct: 912 QEVAQHNLKEASSASQFEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQD 968
Query: 721 ----MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVL 776
K++ L Q QQ+S EEL K I E E+ + + + + + +
Sbjct: 969 ENKLFKSQIEQLKQQNYQQASSFPPHEEL---LKVISEREKEISG---LWNELDSLKDAV 1022
Query: 777 ENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE---- 832
E++ K RE+ + + K D +K KE+QQ+VEA+ LE +E+ ++
Sbjct: 1023 EHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPK 1082
Query: 833 -----HTSYKQQLEAVNEAIK------SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEV 881
+ SY + L + K S +++V+ ++ + E Q E K K V
Sbjct: 1083 VSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1142
Query: 882 ITAQDTVI----KAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKD 937
+ + ++ ++ E K K + ++S IK++ + + ++E E ++ KD
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE----RLRSENKD 1198
Query: 938 YDWINAER-HLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVN--MRAMNVLTEA 994
+ + ER HL + A ++ E + L E+++KL + + +R L
Sbjct: 1199 IENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLL 1258
Query: 995 EERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFG 1042
+ + N+ + K R +N++ K+ + K Q+L + K+ K G
Sbjct: 1259 KAQLNETLTKLRTEQNERQKVAGDL----HKAQQSLELIQSKIVKAAG 1302
Score = 82.4 bits (202), Expect = 2e-15
Identities = 175/924 (18%), Positives = 366/924 (39%), Gaps = 116/924 (12%)
Query: 179 IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQ 238
+ ++ +++ K K+ K +LEE++ +KE +S + +KV E +++
Sbjct: 105 VETSSSVRERKKKEKKQKPVLEEQV------IKESDASKIPGKKV--EPVPVTKQPTPPS 156
Query: 239 FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKAL--NHEIEELEKRKDKETGGIL 296
A K ++ K D K E L K+ +AL + E ++ K+
Sbjct: 157 EAAASKKKP-GQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKK 215
Query: 297 RSLEDALAEAQRV----------NTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLA 346
+ E+ + + N S D ++ + + + ++K+ + KT
Sbjct: 216 QKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTET 275
Query: 347 AKEKEVKKITDGLHALQEASNKDAEALAAA---QQHFNAVSAGLSSNEDGAEATLAGQMM 403
KE K D L +L+ + EAL ++ + L + G TL Q+
Sbjct: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
Query: 404 ACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEA 463
++ + +A + + K QE+ ++ + + + R+K+++
Sbjct: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-------------ERSNVVITRMKDRIGT 382
Query: 464 EMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
K+ N +NK ++ +Q+ +++E EA +A +D N
Sbjct: 383 LEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLES 442
Query: 524 GLVASLISVKDTSATTALEL------VAGERLYNVVVDTEVTGKKLLERGELKRRYTIIP 577
A L ++ A EL + E + + T K ++ E +RR+ +
Sbjct: 443 KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLK-VQLQEAERRWEEVQ 501
Query: 578 LNKISARCIAPETLR--VAQNLVGPDN----VHVAL--SLVEYKPELQKAMEFVFGTTFV 629
+ I R E + + V +N +H L +LV + Q+ M+ +
Sbjct: 502 -SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKR 560
Query: 630 CDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAAS------ILTKFQELKD 683
+ ++ + D I+ + L + H ++ + + I K +++K
Sbjct: 561 VNKEESLQMQVQD--ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618
Query: 684 VQDELRIKENELRALEEELAGLKN---------------------TAEKYRQLKQQWEMK 722
+D L + + L + EEEL ++N A + +++Q +K
Sbjct: 619 TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678
Query: 723 TEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQR----KAEEKYEVLEN 778
++ LL+ +LQ +K +E K + + + LK+ E+Q+ +E+ + +
Sbjct: 679 DDKIRLLEEQLQHEISNKMEE-----FKILNDQNKALKS--EVQKLQTLVSEQPNKDVVE 731
Query: 779 KMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELK---REHTS 835
+M+ E++ +LK ++ L+ + +++ + E ++T E+++LK + S
Sbjct: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
Query: 836 YKQQLEAVNEA-------IKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTV 888
+ +E + + IKS E +E +VA +++V ++E+ KE I +
Sbjct: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI-GNVQL 850
Query: 889 IKAKYAEVAKHKEQNNDSQLKIKELDHNISKH-KREAEDGAAKVSKMLKDYDWINAERHL 947
KA+ + K Q + LK KE N K E E A K L+D N
Sbjct: 851 EKAQQLSITS-KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA 909
Query: 948 FGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRI 1007
Q + ++ K + + L+ + +KEK + AM +ER +DL K ++
Sbjct: 910 HVQEVAQHNLKEASSASQFEELEIV--LKEKENELKRLEAM-----LKERESDLSSKTQL 962
Query: 1008 VEN--DKSKIL-TTIEDLDQKKNQ 1028
+++ D++K+ + IE L Q+ Q
Sbjct: 963 LQDVQDENKLFKSQIEQLKQQNYQ 986
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 112 bits (280), Expect = 2e-24
Identities = 199/948 (20%), Positives = 390/948 (41%), Gaps = 122/948 (12%)
Query: 171 TRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL-----EYQKVMR 225
T+ + K ++ +E + A LK+ IL + ++ T +L+ ++S+ L +Y +++
Sbjct: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460
Query: 226 EI-EHLSRLYIA-YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEE 283
E+ E +L Q AE + +L+E + + ++Q + + + +A +++
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
Query: 284 LEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKE----LEKNMV 339
K+ E + L D L Q++ + + ++K + EES + + LE+N
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEA 580
Query: 340 -----------------------EDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAA 376
E K +A K+K++K+ D L + ++ E L
Sbjct: 581 LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDI 640
Query: 377 QQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLK----HAQQELKN 432
Q + A + + LA + A +++ K Q K++ Q E+ N
Sbjct: 641 QNMNFLLKAEVQKLQ-----ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN 695
Query: 433 KQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRL 492
K E K ++ +AL++ + + L +E + E E+ + EK +L
Sbjct: 696 KMEEFKILND----QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL------- 744
Query: 493 KETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASL--ISVKDTSATTALELVAGERLY 550
+T E LL ++ A K+ E N R L + + K + LV E L
Sbjct: 745 -KTVEELLET-GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLV--EELK 800
Query: 551 NVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVA--LS 608
V+ + + K+ EL + NK + ++ + +G + A LS
Sbjct: 801 KVIHEKD---GKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS 857
Query: 609 LVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTLGGDVFDPHGTLSGGA 667
+ ELQ ++ G + M+ K V +K + + T D+ + + +L
Sbjct: 858 ITSKVQELQNLLK---GKE---EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
Query: 668 RSQA------ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE- 720
+ A AS ++F+EL+ V L+ KENEL+ LE L ++ QL Q +
Sbjct: 912 QEVAQHNLKEASSASQFEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQD 968
Query: 721 ----MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVL 776
K++ L Q QQ+S EEL K I E E+ + + + + + +
Sbjct: 969 ENKLFKSQIEQLKQQNYQQASSFPPHEEL---LKVISEREKEISG---LWNELDSLKDAV 1022
Query: 777 ENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE---- 832
E++ K RE+ + + K D +K KE+QQ+VEA+ LE +E+ ++
Sbjct: 1023 EHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPK 1082
Query: 833 -----HTSYKQQLEAVNEAIK------SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEV 881
+ SY + L + K S +++V+ ++ + E Q E K K V
Sbjct: 1083 VSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1142
Query: 882 ITAQDTVI----KAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKD 937
+ + ++ ++ E K K + ++S IK++ + + ++E E ++ KD
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE----RLRSENKD 1198
Query: 938 YDWINAER-HLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVN--MRAMNVLTEA 994
+ + ER HL + A ++ E + L E+++KL + + +R L
Sbjct: 1199 IENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLL 1258
Query: 995 EERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFG 1042
+ + N+ + K R +N++ K+ + K Q+L + K+ K G
Sbjct: 1259 KAQLNETLTKLRTEQNERQKVAGDL----HKAQQSLELIQSKIVKAAG 1302
Score = 82.4 bits (202), Expect = 2e-15
Identities = 175/924 (18%), Positives = 366/924 (39%), Gaps = 116/924 (12%)
Query: 179 IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQ 238
+ ++ +++ K K+ K +LEE++ +KE +S + +KV E +++
Sbjct: 105 VETSSSVRERKKKEKKQKPVLEEQV------IKESDASKIPGKKV--EPVPVTKQPTPPS 156
Query: 239 FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKAL--NHEIEELEKRKDKETGGIL 296
A K ++ K D K E L K+ +AL + E ++ K+
Sbjct: 157 EAAASKKKP-GQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKK 215
Query: 297 RSLEDALAEAQRV----------NTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLA 346
+ E+ + + N S D ++ + + + ++K+ + KT
Sbjct: 216 QKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTET 275
Query: 347 AKEKEVKKITDGLHALQEASNKDAEALAAA---QQHFNAVSAGLSSNEDGAEATLAGQMM 403
KE K D L +L+ + EAL ++ + L + G TL Q+
Sbjct: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
Query: 404 ACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEA 463
++ + +A + + K QE+ ++ + + + R+K+++
Sbjct: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-------------ERSNVVITRMKDRIGT 382
Query: 464 EMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
K+ N +NK ++ +Q+ +++E EA +A +D N
Sbjct: 383 LEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLES 442
Query: 524 GLVASLISVKDTSATTALEL------VAGERLYNVVVDTEVTGKKLLERGELKRRYTIIP 577
A L ++ A EL + E + + T K ++ E +RR+ +
Sbjct: 443 KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLK-VQLQEAERRWEEVQ 501
Query: 578 LNKISARCIAPETLR--VAQNLVGPDN----VHVAL--SLVEYKPELQKAMEFVFGTTFV 629
+ I R E + + V +N +H L +LV + Q+ M+ +
Sbjct: 502 -SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKR 560
Query: 630 CDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAAS------ILTKFQELKD 683
+ ++ + D I+ + L + H ++ + + I K +++K
Sbjct: 561 VNKEESLQMQVQD--ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618
Query: 684 VQDELRIKENELRALEEELAGLKN---------------------TAEKYRQLKQQWEMK 722
+D L + + L + EEEL ++N A + +++Q +K
Sbjct: 619 TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678
Query: 723 TEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQR----KAEEKYEVLEN 778
++ LL+ +LQ +K +E K + + + LK+ E+Q+ +E+ + +
Sbjct: 679 DDKIRLLEEQLQHEISNKMEE-----FKILNDQNKALKS--EVQKLQTLVSEQPNKDVVE 731
Query: 779 KMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELK---REHTS 835
+M+ E++ +LK ++ L+ + +++ + E ++T E+++LK + S
Sbjct: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
Query: 836 YKQQLEAVNEA-------IKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTV 888
+ +E + + IKS E +E +VA +++V ++E+ KE I +
Sbjct: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI-GNVQL 850
Query: 889 IKAKYAEVAKHKEQNNDSQLKIKELDHNISKH-KREAEDGAAKVSKMLKDYDWINAERHL 947
KA+ + K Q + LK KE N K E E A K L+D N
Sbjct: 851 EKAQQLSITS-KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA 909
Query: 948 FGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRI 1007
Q + ++ K + + L+ + +KEK + AM +ER +DL K ++
Sbjct: 910 HVQEVAQHNLKEASSASQFEELEIV--LKEKENELKRLEAM-----LKERESDLSSKTQL 962
Query: 1008 VEN--DKSKIL-TTIEDLDQKKNQ 1028
+++ D++K+ + IE L Q+ Q
Sbjct: 963 LQDVQDENKLFKSQIEQLKQQNYQ 986
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 111 bits (278), Expect = 4e-24
Identities = 189/876 (21%), Positives = 378/876 (43%), Gaps = 118/876 (13%)
Query: 174 YEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRL 233
++ K + EK+ A +KE T L+E + + + KE LE +K++ ++ + L
Sbjct: 834 FKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKE-----LE-EKMVSLLQEKNDL 887
Query: 234 YIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETG 293
+ Q AE + AEE D++IK + +L + K+K +N +E+ E+ + E
Sbjct: 888 QLQVQ---AEQDNLADAEE---RCDQLIKNKIQL---EAKVKEMNERLED-EEEMNAELT 937
Query: 294 GILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
R LED +E +R D + LA E ++ E + ++ +A ++ +
Sbjct: 938 AKKRKLEDECSELKR-------DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 990
Query: 354 KITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQ 413
K+T ALQEA + + L A + N ++ A+ L Q+ +D+ +
Sbjct: 991 KLTKEKKALQEAHQQALDDLQAEEDKVNTLTK--------AKVKLEQQV----DDLEGSL 1038
Query: 414 TEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEEN 473
+ K+ +M L+ A+ +K++ + QE++ ++ K++L+ +KK ++E N
Sbjct: 1039 EQEKKVRMDLERAK----------RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN 1088
Query: 474 KEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVK 533
+ +E + L +L++ + L AR L ++ E + S +S +
Sbjct: 1089 ALNARIEDEQALG---SQLQKKLKELQARIEELE---EELEAERTARAKVEKLRSDLSRE 1142
Query: 534 DTSATTALELVAGERLYNVVVDT--EVTGKKL---LERGELKRRYTIIPLNKISARCIAP 588
+ LE G + ++ E +K+ LE L+ T L K A +A
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE 1202
Query: 589 ETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTR 648
++ DN L V+ K E +K+ EF V NM+ K + M R
Sbjct: 1203 LGEQI-------DN----LQRVKQKLEKEKS-EFKLELDDVTSNMEQIIKAKANLEKMCR 1250
Query: 649 TVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNT 708
T+ D + H + + + + ++ +L+ EL + +E AL +L K T
Sbjct: 1251 TLE---DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLT 1307
Query: 709 -AEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQR 767
++ LK+Q E + + + L LQ + + + D L++ EE E + +
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARH-----DCDLLREQYEEETEAKAELQRVLS 1362
Query: 768 KAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELE 827
KA + K + +R EL++A+KKL +++++E ++ VEA+ +
Sbjct: 1363 KANSEVAQWRTKYETDAIQRTEELEEAKKKL----------AQRLQEAEEAVEAVNAKCS 1412
Query: 828 ELKREHTSYKQQLEAV-------NEAIKSYESQIEVMAAEVAKNKESVNKAQEEV-TKQK 879
L++ + ++E + N A + + + +A+ K+ ++Q E+ + QK
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472
Query: 880 EVITAQDTVIKAK--YAEVAKH----KEQNNDSQLKIKELD----------HNISKHKRE 923
E + + K K Y E +H K +N + Q +I +L H + K +++
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ 1532
Query: 924 AEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV 983
E ++ L++ + + H G+ A E ++L + E E+ RN
Sbjct: 1533 LEAEKMELQSALEEAE--ASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRN- 1589
Query: 984 NMRAMNVL---TEAEER-YNDLMKKKRIVENDKSKI 1015
++R ++ L +AE R N+ ++ K+ +E D +++
Sbjct: 1590 HLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM 1625
Score = 101 bits (251), Expect = 5e-21
Identities = 168/783 (21%), Positives = 342/783 (43%), Gaps = 133/783 (16%)
Query: 185 IEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQ----KVMREIEHLSRLYIAYQFL 240
I K +A L+++ LE+++ K +E + S + K+ E LSR + L
Sbjct: 1238 IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL 1297
Query: 241 LAEDTK-----VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
+++ T+ + E+LK ++ +K + L+ +++ H+ + L ++ ++ET
Sbjct: 1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH---ALQSARHDCDLLREQYEEET--- 1351
Query: 296 LRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKR-KELEKNMVEDSKTLAAKEKEVKK 354
+A AE QRV +K+ S + + +R +ELE+ + ++ L E+ V+
Sbjct: 1352 -----EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEA 1406
Query: 355 ITDGLHALQEASNK---DAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
+ +L++ ++ + E L + NA +A L + + LA +
Sbjct: 1407 VNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA-----------E 1455
Query: 412 AQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYE 471
+ + +++Q +L+ +Q+E ++ E+ K+ + Y + E LE KR + L+ E+ L +
Sbjct: 1456 WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQ 1515
Query: 472 ---ENKEESLLEK-RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVA 527
K LEK R+QL + L+ E A + + +N+ +K +
Sbjct: 1516 LGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQ--IKAEIE 1573
Query: 528 SLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIA 587
++ KD E+ +R + VVD+ T R
Sbjct: 1574 RKLAEKDE------EMEQAKRNHLRVVDSLQTSLDAETRSR------------------- 1608
Query: 588 PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMT 647
E LRV + + G N + E+Q + +A ++A + +
Sbjct: 1609 NEALRVKKKMEGDLN----------EMEIQ---------------LSHANRMAAEAQKQV 1643
Query: 648 RTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKN 707
+++ +L + Q + +LK+ + + N L+A EEL +
Sbjct: 1644 KSLQ----------SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Query: 708 TAEKYRQLKQQWEMKTEE-ADLLQTKLQQSSYHKQQEELDA----LKKTIEESEETLKNT 762
E+ R+L +Q ++T E LL + Q +S Q++++DA L+ +EE+ + +N
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHS--QNTSLINQKKKMDADLSQLQTEVEEAVQECRNA 1751
Query: 763 KEIQRKAEEKYEVLENKMK-----NAEAER-----ERELKDAQKKLDCAKTKADASSKKM 812
+E +KA ++ ++K +A ER E+ +KD Q +LD A+ A KK
Sbjct: 1752 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811
Query: 813 KEKQQEVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKA 871
+K +EA ELE EL+ E K+ E+V KS E +I+ + + ++++++ +
Sbjct: 1812 LQK---LEARVRELENELEAEQ---KRNAESVKGMRKS-ERRIKELTYQTEEDRKNLLRL 1864
Query: 872 QEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKV 931
Q+ V K + +KA + + +EQ N + K +++ H + + + A+ ++V
Sbjct: 1865 QDLVDKLQ-------LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQV 1917
Query: 932 SKM 934
+K+
Sbjct: 1918 NKL 1920
Score = 89.7 bits (221), Expect = 1e-17
Identities = 199/1000 (19%), Positives = 392/1000 (39%), Gaps = 152/1000 (15%)
Query: 149 RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKI---AAQKTIEKKEAKLKEIKTI-- 198
++ K + ++ ++ EE AG ++ + KK A Q+ ++ +A+ ++ T+
Sbjct: 963 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTK 1022
Query: 199 ----LEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELK 254
LE+++ L++E+ ++ ++ R++E +L + E+ K + E LK
Sbjct: 1023 AKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL-TQESIMDLENDKQQLDERLK 1081
Query: 255 EMQDKVIKLQEEL-------SENDKKIKALNHEIEELEKRKDKET----------GGILR 297
+ ++ L + S+ KK+K L IEELE+ + E + R
Sbjct: 1082 KKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSR 1141
Query: 298 SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKE----VK 353
LE+ + + ++ KK A + R++LE+ ++ T AA K+ V
Sbjct: 1142 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVA 1201
Query: 354 KITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDG---AEATLAGQMMACKNDIS 410
++ + + LQ K L + F ++SN + A+A L ++ ++
Sbjct: 1202 ELGEQIDNLQRVKQK----LEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN 1257
Query: 411 KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLK----EKLEAEMK 466
+ +++A++ Q + + Q E ++ + + + + R K ++LE +
Sbjct: 1258 EHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR 1317
Query: 467 KLNYEENKEESLLEKRRQLSRDIGRLKETYEA---LLARFPNLRFAYKDPEKNWNRNCVK 523
+L E + +L + D L+E YE A + W
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1377
Query: 524 GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA 583
+ +++ A +RL E K + K R N+I
Sbjct: 1378 DAIQRTEELEEAKKKLA------QRLQEAEEAVEAVNAKCSSLEKTKHRLQ----NEIED 1427
Query: 584 RCIAPETLRVAQNLVGPDNVHVALSLVEYKP-------ELQKAMEFVFGTTFVCDNMDNA 636
+ E A + + L E+K EL+ + + + + NA
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 637 KKVAFD--KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
+ + + + L ++ D L ++ EL+ V+ +L ++ E
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISDLTEQLGSSGKT--------IHELEKVRKQLEAEKME 1539
Query: 695 LR-ALEEELAGLKNTAEK-------YRQLKQQWEMKTEE---------------ADLLQT 731
L+ ALEE A L++ K + Q+K + E K E D LQT
Sbjct: 1540 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQT 1599
Query: 732 KLQQSSYHKQQEELDALKKTIE----ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAER 787
L + + + E +KK +E E E L + + +A+++ + L++ +K+ + +
Sbjct: 1600 SLDAET--RSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ- 1656
Query: 788 ERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAI 847
L DA + D K ++ Q E+E + +E+ +R +Q+L +E +
Sbjct: 1657 ---LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1713
Query: 848 KSYESQIEVMAAEVAKNKESVNKAQEEVTKQ-KEVITAQDTVIK-----AKYAEVAKHKE 901
+ SQ + + K +++ Q EV + +E A++ K A AE K KE
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELK-KE 1772
Query: 902 QNNDSQLK---------IKELDHNISKHKREAEDGAAK-----------VSKMLKDYDWI 941
Q+ + L+ IK+L H + + ++ A G K + L+
Sbjct: 1773 QDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKR 1832
Query: 942 NAERHLFGQPNSAYDFK--TNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYN 999
NAE + G S K T +E + L +LQ++ +KL V EAEE+ N
Sbjct: 1833 NAE-SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQA-EEAEEQAN 1890
Query: 1000 DLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNK 1039
+ K R V++ +LD+ + +A +IA +VNK
Sbjct: 1891 TNLSKFRKVQH----------ELDEAEERA-DIAESQVNK 1919
Score = 89.4 bits (220), Expect = 2e-17
Identities = 133/691 (19%), Positives = 277/691 (40%), Gaps = 110/691 (15%)
Query: 388 SSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD 447
S+ + A++ + K + K++ K+ + K+ QE + Q +V+
Sbjct: 842 SAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADA 901
Query: 448 QEALEAVKRLKEKLEAEMKKLNY----EENKEESLLEKRRQLSRDIGRLKETYEALLARF 503
+E + + + K +LEA++K++N EE L K+R+L + LK + L
Sbjct: 902 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL---- 957
Query: 504 PNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL 563
L A + EK+ N VK L + + + A E KK
Sbjct: 958 -ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKE------------------KKA 998
Query: 564 LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFV 623
L+ + A + L+ ++ V +L + K +L++ ++ +
Sbjct: 999 LQEAHQQ----------------ALDDLQAEEDKVN--------TLTKAKVKLEQQVDDL 1034
Query: 624 FGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD 683
G+ ++ KKV D R L G + SI+ + +
Sbjct: 1035 EGS------LEQEKKVRMDLERAKRK-------------LEGDLKLTQESIMDLENDKQQ 1075
Query: 684 VQDELRIKENELRAL----EEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYH 739
+ + L+ K+ EL AL E+E A +K ++L+ + E EE + +T +
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135
Query: 740 KQQ--EELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKK 797
+ EL+ + + +EE+ E+ +K E +++ + ++ A + E +KK
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195
Query: 798 -----------LDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEA 846
+D + K+ E + E++ +T +E++ + + ++ + +
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQ 1255
Query: 847 IKSYESQIEVMAAEV---AKNKESVNKAQEEVTKQ---KEVITAQDTVIKAKYAEVAKHK 900
+ + S+ E V + + E+++Q KE + +Q T K Y + +
Sbjct: 1256 MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDL 1315
Query: 901 EQNNDSQLKIKE-LDHNISKHKREAEDGAAKVSKMLKDYDWINAE-RHLFGQPNSAY-DF 957
++ + ++K K L H + + + + + + ++ AE + + + NS +
Sbjct: 1316 KRQLEEEVKAKNALAHALQSARHDCD----LLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 958 KTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILT 1017
+T +A QR ++L+E K+KL + L EAEE + K +E K ++
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQR--------LQEAEEAVEAVNAKCSSLEKTKHRLQN 1423
Query: 1018 TIEDL--DQKKNQALNIAWQKVNKDFGSIFS 1046
IEDL D +++ A A K ++F I +
Sbjct: 1424 EIEDLMVDVERSNAAAAALDKKQRNFDKILA 1454
Score = 52.8 bits (125), Expect = 2e-06
Identities = 85/417 (20%), Positives = 172/417 (41%), Gaps = 91/417 (21%)
Query: 149 RITKVLNMKPPEILSMIEEAAGTRMYEYKKIA-----------------AQKTIEKKEAK 191
++ K L + E+ S +EEA + +E KI A+K E ++AK
Sbjct: 1528 KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1587
Query: 192 ------LKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI-------AYQ 238
+ ++T L+ E + L+ ++ + ++ ++ H +R+ + Q
Sbjct: 1588 RNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1647
Query: 239 FLLAE-----DTKVRSAEELKE-----------MQDKVIKL--------------QEELS 268
LL + D VR+ ++LKE +Q ++ +L ++EL
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707
Query: 269 ENDKKIKALNHEIEEL---EKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLA 325
E ++++ L+ + L +K+ D + + +E+A+ E + K++ A + +
Sbjct: 1708 ETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKA--ITDAAMM 1765
Query: 326 CEESKRKE--------LEKNMVEDSKTLAAKEKEVKKIT--DGLHALQ--EASNKDAEAL 373
EE K+++ ++KNM + K L + E ++I G LQ EA ++ E
Sbjct: 1766 AEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENE 1825
Query: 374 AAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNK 433
A+Q NA S + L Q + ++ + Q + Q+K+K +++ +
Sbjct: 1826 LEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEA 1885
Query: 434 QAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIG 490
+ + S +RK Q L+ + + E+++ KL R SRDIG
Sbjct: 1886 EEQANTNLSKFRKVQHELDEAEERADIAESQVNKL--------------RAKSRDIG 1928
Score = 32.3 bits (72), Expect = 2.8
Identities = 31/133 (23%), Positives = 61/133 (45%), Gaps = 16/133 (12%)
Query: 892 KYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQP 951
K AE K + ++KE ++E E+ K+ +L++ + + +
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEE---KMVSLLQEKNDLQLQ------- 890
Query: 952 NSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYN-DLMKKKRIVEN 1010
+ +N +A +R +L +K K+ ++ MN E EE N +L KKR +E+
Sbjct: 891 ---VQAEQDNLADAEERCDQL--IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 945
Query: 1011 DKSKILTTIEDLD 1023
+ S++ I+DL+
Sbjct: 946 ECSELKRDIDDLE 958
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 107 bits (268), Expect = 5e-23
Identities = 201/970 (20%), Positives = 395/970 (40%), Gaps = 158/970 (16%)
Query: 132 CSVGLNVNNPHFLIMQGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
C+ L + N + + ++ +L + + E+ + +E T+ + K K +E+K
Sbjct: 823 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 882
Query: 190 AKLKEIKTILEEEI---TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTK 246
++L E K +L+E++ T + +E R ++ + EI H + + ED
Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRG 938
Query: 247 VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
+ E K+M +++ L+E+L E + + L E E + ++ LED +
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK--------IKKLEDEILVM 990
Query: 307 QRVNTKSQSAFDLKKK-------NLACEESKRKELEK------NMVEDSKTLAAKEKEVK 353
N K L ++ NLA EE K K L K +M+ + + KE++ +
Sbjct: 991 DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 354 KITDGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNEDGAEATLA--GQMMACKNDIS 410
+ + L E D E +A Q + L+ E+ +A LA +A KN+
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 411 KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK-RLKEKLE--AEMKK 467
K + ++ + + Q++L +++A K + R E LEA+K L++ L+ A ++
Sbjct: 1111 K---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 468 LNYEENKEESLL-----EKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
L + +E ++L E+ R + +++ + + +K + N ++N
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-- 1225
Query: 523 KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
K T +L AGE V G+ E E K++ + ++
Sbjct: 1226 ----------KQTLEKENADL-AGE--------LRVLGQAKQE-VEHKKKKLEAQVQELQ 1265
Query: 583 ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
++C E R N D VH +LQ +E V G +
Sbjct: 1266 SKCSDGERARAELN----DKVH----------KLQNEVESVTGMLNEAEG---------- 1301
Query: 643 KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD-VQDELRIKEN---ELRAL 698
+ + L DV AS+ ++ Q+ ++ +Q+E R K N +LR L
Sbjct: 1302 -----KAIKLAKDV---------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 699 EEELAGLKNTAEKYRQLKQQWE--MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
EEE L++ ++ + KQ E + T L +K + + E L+ KK ++
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 757 ETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERE----LKDAQKKLDCAKTKAD 806
E L E + A +K E +N+++ + + +R+ L+ Q+K D +
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 807 ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAK 863
S K +++ EA E E + + S + LE EA + E +++ AE +
Sbjct: 1462 NISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 864 NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK--------ELDH 915
+K+ V K E+ K K + Q +K + E+ + D++L+++ + +
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 916 NISKHKREAEDGAAKVSKMLKDYDW------------INAERHLFGQPNS---AYDFKTN 960
++ + E+ ++ + L +Y+ A++ L G D
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 961 NPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI 1019
+EA ++L+KLQ +MK+ + RA A + N+ KK + +E D ++ +
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--KKAKSLEADLMQLQEDL 1696
Query: 1020 EDLDQKKNQA 1029
++ + QA
Sbjct: 1697 AAAERARKQA 1706
Score = 103 bits (257), Expect = 1e-21
Identities = 148/737 (20%), Positives = 306/737 (41%), Gaps = 111/737 (15%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
E+ A+L + L+ E+ L E + K+ +++ LS Q LL E+T
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI---KLAKDVASLSSQLQDTQELLQEET 1328
Query: 246 --KVRSAEELKEMQDKVIKLQEELSEN-------DKKIKALNHEIEELEKRKDKETGGIL 296
K+ + +L++++++ LQ++L E ++ I LN ++ + K+K ++ +
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD-SKKKLQDFASTV 1387
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
+LE+ Q+ ++ K A K ++ + + ++ L +++
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
L E + + L A +++ +S+ + D AEA A + +++A EA
Sbjct: 1444 SNL----EKKQRKFDQLLAEEKN---ISSKYADERDRAEAE-AREKETKALSLARALEEA 1495
Query: 417 KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEE 476
+A+ +L+ + LK + ++ K+ LE KR E EMK EE ++E
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT-QLEELEDE 1554
Query: 477 SLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTS 536
+ +L RL+ +AL +F A + + R + L ++D
Sbjct: 1555 LQATEDAKL-----RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 537 ATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQN 596
AL A ++L + D E+ ++ R I L K+ A+
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKG----REEAIKQLRKLQAQ------------ 1653
Query: 597 LVGPDNVHVALSLVEYKPELQKAM---EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG 653
+ +++ EL+ A + +F T +N KK +L
Sbjct: 1654 ------------MKDFQRELEDARASRDEIFATA-----KENEKKAK----------SLE 1686
Query: 654 GDVFDPHGTLSGGARSQAASILTKFQELKD-----------VQDELRIKENELRALEEEL 702
D+ L+ R++ + L K +EL + +QDE R E + LEEEL
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 703 ----AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEET 758
++ +++ R+ QQ E + E ++ Q++ +QQ E
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE-------------- 1791
Query: 759 LKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
+ KE++ K E +++K K+ A E ++ +++++ + A++K +K+K ++
Sbjct: 1792 -RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 819 VEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAKNKESVNKAQEEV 875
++ I L++E+ ++ YK+Q E N +K + Q+E E + N+ + + +E
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 876 TKQKEVITAQDTVIKAK 892
T+ E + + +K+K
Sbjct: 1911 TESNEAMGREVNALKSK 1927
Score = 101 bits (251), Expect = 5e-21
Identities = 157/815 (19%), Positives = 347/815 (42%), Gaps = 89/815 (10%)
Query: 178 KIAAQKTIEKKEAKLKEIK---TILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
K A + EA+++E++ EE+T +++ K +++ L+ K E E+
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENAD--- 1235
Query: 235 IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG 294
+A + + K + K+++ +V +LQ + S+ ++ LN ++ +L+ + TG
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG- 1294
Query: 295 ILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKK 354
L +A +A ++ K++A S+ ++ ++ + E+++ ++++
Sbjct: 1295 ---MLNEAEGKAIKL-----------AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 355 ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
+ + ++LQ+ +++ EA ++H + ++ LS ++ ++ + + +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK--------KLQDFASTVEALEE 1392
Query: 415 EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV-------KRLKEKLEAEMKK 467
K+ Q ++++ Q+ + K A K++ + Q+ L+ + ++L LE + +K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452
Query: 468 LNY---EENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKG 524
+ EE S R + R KET LAR K+ + N+ +K
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKA 1511
Query: 525 LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISAR 584
+ L+S KD EL +R ++ T + LE EL+ +++ +
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQ 1570
Query: 585 CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKR 644
+ + R +L D + E + +LQ+ + + T + A A K+
Sbjct: 1571 ALKGQFER---DLQARDEQNE-----EKRRQLQRQLH-EYETELEDERKQRALAAAAKKK 1621
Query: 645 IMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENELRALEEE 701
L GD+ D R +A L K Q ++KD Q EL + RA +E
Sbjct: 1622 -------LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE----DARASRDE 1670
Query: 702 LAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI-EESEETLK 760
+ EK + K+ EADL+Q + ++ + +++ D K+ + EE +L
Sbjct: 1671 IFATAKENEK--------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 761 NTKEIQ---RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQ 817
+Q R+ E + LE +++ + E + D +K A +A+ S ++ ++
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRK---ATQQAEQLSNELATERS 1778
Query: 818 EVEAITLELEELKREHTSYKQQLEAVNEAIKS-YESQIEVMAAEVAKNKESVNKAQEEVT 876
+ ++L+R++ + +L + A+KS ++S I + A++A+ +E V + E
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 877 KQKEVITAQDTVIKAKYAEVA-------KHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
+ + +D +K +V ++KEQ ++K+L + + + E++ A
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 930 KVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE 964
K+ ++ D G+ +A K E
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 95.1 bits (235), Expect = 3e-19
Identities = 188/933 (20%), Positives = 373/933 (39%), Gaps = 120/933 (12%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAE- 243
E+K L ++K E I+ +LK+E S E +K+ R++E S + L A+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 244 -DTKVRSAEELKEMQDKVIKLQEELSEND---KKIKALNHEIEELEKRKDKETGG---IL 296
+ K++ A++ +E+Q + +L +E+++ + KKI+ L I +L++ D E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
+ D E + + T+ + D + A ++ R + E+ + K L ++E +
Sbjct: 1139 KQKRDLGEELEALKTELEDTLD----STATQQELRAKREQEVTVLKKAL---DEETRSHE 1191
Query: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAGQMMACKNDISKAQ 413
+ +++ + E L + F A L N+ E A LAG++ + +A+
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV----LGQAK 1247
Query: 414 TEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
E + + KL+ QEL++K ++ ++ ++ K Q +E+V + + E + KL
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 470 YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK---DPEKNWNRNCVKGLV 526
+ S L+ ++L ++ R K L + R + + D E +N + +
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 527 ASLISVKDTS------ATTALELVAGERLYNVVVDT---------------EVTGKKL-- 563
I + D+ A+T L G++ + ++ E T +L
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 564 ------------------LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHV 605
LE+ + K + IS++ A+ +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE---AREKETK 1484
Query: 606 ALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSG 665
ALSL E +A E ++ K+ K M V+ DV L
Sbjct: 1485 ALSLARALEEALEAKE----------ELERTNKML--KAEMEDLVSSKDDVGKNVHELEK 1532
Query: 666 GARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEE 725
R+ + +L++++DEL+ E+ LE + LK E R L+ + E E+
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEK 1590
Query: 726 ADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
LQ +L + KQ+ A KK +E + L+ + K E+ K+
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV--------------EAITLEL 826
+ + +REL+DA+ D A + KK K + ++ + LE
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 827 EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK---NKESVNKAQEEVTKQ----- 878
EEL E S A+ + + E++I + E+ + N E+++ + T+Q
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 879 KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI-SKHKREAEDGAAKVSKMLKD 937
E+ T + T K + A + + QN + + K+ E++ + SK K AK++++ +
Sbjct: 1771 NELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 938 YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNV---LTEA 994
+ E+ + D K + +K+ E ++ N R + L EA
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 995 EERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
EE + +R ++ + + + E + ++ N
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 84.0 bits (206), Expect = 8e-16
Identities = 179/896 (19%), Positives = 354/896 (39%), Gaps = 99/896 (11%)
Query: 204 TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKL 263
T + L+EER L+ V+ + + R Y+A + ++ + + ++ +KL
Sbjct: 772 TGVLAHLEEERD--LKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKL 829
Query: 264 QE----ELSENDKKIKALNHEIEELEKRKDK--ETGGILRSLEDALAEAQRVNTKSQSAF 317
+ L K + + + EE++ ++D+ +T + E+ L E ++ +++
Sbjct: 830 RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK 889
Query: 318 DLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQ 377
+L ++ L E E E+ V LAAK++E+++I + A E + L A +
Sbjct: 890 NLLQEQLQAETELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 378 QHFNAVSAGLSSN---EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
+ L E+ A L + + + I K + E + +E K +
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 435 AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESL---LEK-RRQLSRDIG 490
+ + + +++E + + +LK K E+ + +L KEE LEK +R+L D
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 491 RLKETYEALLARFPNLR-------------FAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
E L A+ L+ A D E N +K + + D
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 538 TTALELVA-----------GERLYNVVVDTEVTGKKLLERGEL--KRRYTIIPLNKISAR 584
E A GE L + + E T + EL KR + L K
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 585 CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT--TFVCDNMDNAKKVAF- 641
+V + + + L E + ++A + T +N D A ++
Sbjct: 1186 ETRSHEAQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 642 ---DKRIMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENEL 695
+ + + L V + S G AR++ + K Q E++ V L E +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 696 RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
L +++A L + + ++L Q+ +T + + TKL+Q +EE ++L+ ++E
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQE---ETRQKLNVSTKLRQ-----LEEERNSLQDQLDEE 1355
Query: 756 EETLKN------TKEIQ-RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADAS 808
E +N T IQ +++K + + ++ E ++R K+ + + KA A
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 809 SKKMKEK---QQEVEAITLELE-------ELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
K K K QQE++ + ++L+ L+++ + Q L Y + +
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 859 AEVAKNKE----SVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
AE A+ KE S+ +A EE + KE + + ++KA+ ++ K+ + +
Sbjct: 1476 AE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-------VGKNV 1527
Query: 915 HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
H + K KR E ++ L++ E L ++ + N GQ + LQ
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEE-----LEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 975 MKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
E+ + L E E D K++ + K K+ ++DL+ + + A+
Sbjct: 1583 RDEQ-NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Score = 73.2 bits (178), Expect = 1e-12
Identities = 74/375 (19%), Positives = 168/375 (44%), Gaps = 29/375 (7%)
Query: 675 LTKFQELKDVQDELRIKEN-------ELRALEEELAGLK-NTAEKYRQLKQQWEMKTEEA 726
+T ++K ++DE+ + ++ E + LEE ++ L N AE+ + K ++K +
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 727 DLL-QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
++ + +++ K ++EL+ LK+ +E ++ A+ + ++ E KM+ A+
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-----EQIADLQAQIAELKMQLAK- 1087
Query: 786 ERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE 845
+E EL+ A +LD + + + KK++E + + + +L+ + ++Q + E
Sbjct: 1088 -KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 846 AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND 905
+++ ++++E A +E K ++EVT K+ + + +A+ E+ + Q
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ--- 1203
Query: 906 SQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEA 965
++EL + + KR + + K+ + E + GQ + K +
Sbjct: 1204 ---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 966 GQRLQKLQEMKEKLGRNVNMRAMNVLTEAE-------ERYNDLMKKKRIVENDKSKILTT 1018
Q LQ E+ +N + + E E E +K + V + S++ T
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 1019 IEDLDQKKNQALNIA 1033
E L ++ Q LN++
Sbjct: 1321 QELLQEETRQKLNVS 1335
Score = 35.8 bits (81), Expect = 0.25
Identities = 34/145 (23%), Positives = 63/145 (43%), Gaps = 28/145 (19%)
Query: 177 KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
+K AA K++++K+ KLKEI +E+E Q ++ +++ R++E
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE-------- 1887
Query: 237 YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK--RKDKET-- 292
+ EE + + KLQ EL E + +A+ E+ L+ R+ ET
Sbjct: 1888 -----------EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1936
Query: 293 -----GGILRSLEDALAEAQRVNTK 312
G R +E+A + +T+
Sbjct: 1937 VPSRRSGGRRVIENADGSEEETDTR 1961
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 107 bits (268), Expect = 5e-23
Identities = 201/970 (20%), Positives = 395/970 (40%), Gaps = 158/970 (16%)
Query: 132 CSVGLNVNNPHFLIMQGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
C+ L + N + + ++ +L + + E+ + +E T+ + K K +E+K
Sbjct: 830 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 889
Query: 190 AKLKEIKTILEEEI---TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTK 246
++L E K +L+E++ T + +E R ++ + EI H + + ED
Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRG 945
Query: 247 VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
+ E K+M +++ L+E+L E + + L E E + ++ LED +
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK--------IKKLEDEILVM 997
Query: 307 QRVNTKSQSAFDLKKK-------NLACEESKRKELEK------NMVEDSKTLAAKEKEVK 353
N K L ++ NLA EE K K L K +M+ + + KE++ +
Sbjct: 998 DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 354 KITDGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNEDGAEATLA--GQMMACKNDIS 410
+ + L E D E +A Q + L+ E+ +A LA +A KN+
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 411 KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK-RLKEKLE--AEMKK 467
K + ++ + + Q++L +++A K + R E LEA+K L++ L+ A ++
Sbjct: 1118 K---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 468 LNYEENKEESLL-----EKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
L + +E ++L E+ R + +++ + + +K + N ++N
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-- 1232
Query: 523 KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
K T +L AGE V G+ E E K++ + ++
Sbjct: 1233 ----------KQTLEKENADL-AGE--------LRVLGQAKQE-VEHKKKKLEAQVQELQ 1272
Query: 583 ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
++C E R N D VH +LQ +E V G +
Sbjct: 1273 SKCSDGERARAELN----DKVH----------KLQNEVESVTGMLNEAEG---------- 1308
Query: 643 KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD-VQDELRIKEN---ELRAL 698
+ + L DV AS+ ++ Q+ ++ +Q+E R K N +LR L
Sbjct: 1309 -----KAIKLAKDV---------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 699 EEELAGLKNTAEKYRQLKQQWE--MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
EEE L++ ++ + KQ E + T L +K + + E L+ KK ++
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 757 ETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERE----LKDAQKKLDCAKTKAD 806
E L E + A +K E +N+++ + + +R+ L+ Q+K D +
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 807 ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAK 863
S K +++ EA E E + + S + LE EA + E +++ AE +
Sbjct: 1469 NISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 864 NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK--------ELDH 915
+K+ V K E+ K K + Q +K + E+ + D++L+++ + +
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 916 NISKHKREAEDGAAKVSKMLKDYDW------------INAERHLFGQPNS---AYDFKTN 960
++ + E+ ++ + L +Y+ A++ L G D
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 961 NPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI 1019
+EA ++L+KLQ +MK+ + RA A + N+ KK + +E D ++ +
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--KKAKSLEADLMQLQEDL 1703
Query: 1020 EDLDQKKNQA 1029
++ + QA
Sbjct: 1704 AAAERARKQA 1713
Score = 103 bits (257), Expect = 1e-21
Identities = 148/737 (20%), Positives = 306/737 (41%), Gaps = 111/737 (15%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
E+ A+L + L+ E+ L E + K+ +++ LS Q LL E+T
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI---KLAKDVASLSSQLQDTQELLQEET 1335
Query: 246 --KVRSAEELKEMQDKVIKLQEELSEN-------DKKIKALNHEIEELEKRKDKETGGIL 296
K+ + +L++++++ LQ++L E ++ I LN ++ + K+K ++ +
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD-SKKKLQDFASTV 1394
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
+LE+ Q+ ++ K A K ++ + + ++ L +++
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
L E + + L A +++ +S+ + D AEA A + +++A EA
Sbjct: 1451 SNL----EKKQRKFDQLLAEEKN---ISSKYADERDRAEAE-AREKETKALSLARALEEA 1502
Query: 417 KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEE 476
+A+ +L+ + LK + ++ K+ LE KR E EMK EE ++E
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT-QLEELEDE 1561
Query: 477 SLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTS 536
+ +L RL+ +AL +F A + + R + L ++D
Sbjct: 1562 LQATEDAKL-----RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 537 ATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQN 596
AL A ++L + D E+ ++ R I L K+ A+
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKG----REEAIKQLRKLQAQ------------ 1660
Query: 597 LVGPDNVHVALSLVEYKPELQKAM---EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG 653
+ +++ EL+ A + +F T +N KK +L
Sbjct: 1661 ------------MKDFQRELEDARASRDEIFATA-----KENEKKAK----------SLE 1693
Query: 654 GDVFDPHGTLSGGARSQAASILTKFQELKD-----------VQDELRIKENELRALEEEL 702
D+ L+ R++ + L K +EL + +QDE R E + LEEEL
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 703 ----AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEET 758
++ +++ R+ QQ E + E ++ Q++ +QQ E
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE-------------- 1798
Query: 759 LKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
+ KE++ K E +++K K+ A E ++ +++++ + A++K +K+K ++
Sbjct: 1799 -RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 819 VEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAKNKESVNKAQEEV 875
++ I L++E+ ++ YK+Q E N +K + Q+E E + N+ + + +E
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 876 TKQKEVITAQDTVIKAK 892
T+ E + + +K+K
Sbjct: 1918 TESNEAMGREVNALKSK 1934
Score = 101 bits (251), Expect = 5e-21
Identities = 157/815 (19%), Positives = 347/815 (42%), Gaps = 89/815 (10%)
Query: 178 KIAAQKTIEKKEAKLKEIK---TILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
K A + EA+++E++ EE+T +++ K +++ L+ K E E+
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENAD--- 1242
Query: 235 IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG 294
+A + + K + K+++ +V +LQ + S+ ++ LN ++ +L+ + TG
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG- 1301
Query: 295 ILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKK 354
L +A +A ++ K++A S+ ++ ++ + E+++ ++++
Sbjct: 1302 ---MLNEAEGKAIKL-----------AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 355 ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
+ + ++LQ+ +++ EA ++H + ++ LS ++ ++ + + +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK--------KLQDFASTVEALEE 1399
Query: 415 EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV-------KRLKEKLEAEMKK 467
K+ Q ++++ Q+ + K A K++ + Q+ L+ + ++L LE + +K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459
Query: 468 LNY---EENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKG 524
+ EE S R + R KET LAR K+ + N+ +K
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKA 1518
Query: 525 LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISAR 584
+ L+S KD EL +R ++ T + LE EL+ +++ +
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQ 1577
Query: 585 CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKR 644
+ + R +L D + E + +LQ+ + + T + A A K+
Sbjct: 1578 ALKGQFER---DLQARDEQNE-----EKRRQLQRQLH-EYETELEDERKQRALAAAAKKK 1628
Query: 645 IMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENELRALEEE 701
L GD+ D R +A L K Q ++KD Q EL + RA +E
Sbjct: 1629 -------LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE----DARASRDE 1677
Query: 702 LAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI-EESEETLK 760
+ EK + K+ EADL+Q + ++ + +++ D K+ + EE +L
Sbjct: 1678 IFATAKENEK--------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 761 NTKEIQ---RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQ 817
+Q R+ E + LE +++ + E + D +K A +A+ S ++ ++
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRK---ATQQAEQLSNELATERS 1785
Query: 818 EVEAITLELEELKREHTSYKQQLEAVNEAIKS-YESQIEVMAAEVAKNKESVNKAQEEVT 876
+ ++L+R++ + +L + A+KS ++S I + A++A+ +E V + E
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 877 KQKEVITAQDTVIKAKYAEVA-------KHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
+ + +D +K +V ++KEQ ++K+L + + + E++ A
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 930 KVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE 964
K+ ++ D G+ +A K E
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 95.1 bits (235), Expect = 3e-19
Identities = 188/933 (20%), Positives = 373/933 (39%), Gaps = 120/933 (12%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAE- 243
E+K L ++K E I+ +LK+E S E +K+ R++E S + L A+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 244 -DTKVRSAEELKEMQDKVIKLQEELSEND---KKIKALNHEIEELEKRKDKETGG---IL 296
+ K++ A++ +E+Q + +L +E+++ + KKI+ L I +L++ D E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
+ D E + + T+ + D + A ++ R + E+ + K L ++E +
Sbjct: 1146 KQKRDLGEELEALKTELEDTLD----STATQQELRAKREQEVTVLKKAL---DEETRSHE 1198
Query: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAGQMMACKNDISKAQ 413
+ +++ + E L + F A L N+ E A LAG++ + +A+
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV----LGQAK 1254
Query: 414 TEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
E + + KL+ QEL++K ++ ++ ++ K Q +E+V + + E + KL
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 470 YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK---DPEKNWNRNCVKGLV 526
+ S L+ ++L ++ R K L + R + + D E +N + +
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 527 ASLISVKDTS------ATTALELVAGERLYNVVVDT---------------EVTGKKL-- 563
I + D+ A+T L G++ + ++ E T +L
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 564 ------------------LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHV 605
LE+ + K + IS++ A+ +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE---AREKETK 1491
Query: 606 ALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSG 665
ALSL E +A E ++ K+ K M V+ DV L
Sbjct: 1492 ALSLARALEEALEAKE----------ELERTNKML--KAEMEDLVSSKDDVGKNVHELEK 1539
Query: 666 GARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEE 725
R+ + +L++++DEL+ E+ LE + LK E R L+ + E E+
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEK 1597
Query: 726 ADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
LQ +L + KQ+ A KK +E + L+ + K E+ K+
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV--------------EAITLEL 826
+ + +REL+DA+ D A + KK K + ++ + LE
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 827 EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK---NKESVNKAQEEVTKQ----- 878
EEL E S A+ + + E++I + E+ + N E+++ + T+Q
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 879 KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI-SKHKREAEDGAAKVSKMLKD 937
E+ T + T K + A + + QN + + K+ E++ + SK K AK++++ +
Sbjct: 1778 NELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 938 YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNV---LTEA 994
+ E+ + D K + +K+ E ++ N R + L EA
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Query: 995 EERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
EE + +R ++ + + + E + ++ N
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 84.0 bits (206), Expect = 8e-16
Identities = 179/896 (19%), Positives = 354/896 (39%), Gaps = 99/896 (11%)
Query: 204 TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKL 263
T + L+EER L+ V+ + + R Y+A + ++ + + ++ +KL
Sbjct: 779 TGVLAHLEEERD--LKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKL 836
Query: 264 QE----ELSENDKKIKALNHEIEELEKRKDK--ETGGILRSLEDALAEAQRVNTKSQSAF 317
+ L K + + + EE++ ++D+ +T + E+ L E ++ +++
Sbjct: 837 RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK 896
Query: 318 DLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQ 377
+L ++ L E E E+ V LAAK++E+++I + A E + L A +
Sbjct: 897 NLLQEQLQAETELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 378 QHFNAVSAGLSSN---EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
+ L E+ A L + + + I K + E + +E K +
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 435 AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESL---LEK-RRQLSRDIG 490
+ + + +++E + + +LK K E+ + +L KEE LEK +R+L D
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 491 RLKETYEALLARFPNLR-------------FAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
E L A+ L+ A D E N +K + + D
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 538 TTALELVA-----------GERLYNVVVDTEVTGKKLLERGEL--KRRYTIIPLNKISAR 584
E A GE L + + E T + EL KR + L K
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 585 CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT--TFVCDNMDNAKKVAF- 641
+V + + + L E + ++A + T +N D A ++
Sbjct: 1193 ETRSHEAQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 642 ---DKRIMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENEL 695
+ + + L V + S G AR++ + K Q E++ V L E +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 696 RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
L +++A L + + ++L Q+ +T + + TKL+Q +EE ++L+ ++E
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQE---ETRQKLNVSTKLRQ-----LEEERNSLQDQLDEE 1362
Query: 756 EETLKN------TKEIQ-RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADAS 808
E +N T IQ +++K + + ++ E ++R K+ + + KA A
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 809 SKKMKEK---QQEVEAITLELE-------ELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
K K K QQE++ + ++L+ L+++ + Q L Y + +
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 859 AEVAKNKE----SVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
AE A+ KE S+ +A EE + KE + + ++KA+ ++ K+ + +
Sbjct: 1483 AE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-------VGKNV 1534
Query: 915 HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
H + K KR E ++ L++ E L ++ + N GQ + LQ
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEE-----LEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 975 MKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
E+ + L E E D K++ + K K+ ++DL+ + + A+
Sbjct: 1590 RDEQ-NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Score = 73.2 bits (178), Expect = 1e-12
Identities = 74/375 (19%), Positives = 168/375 (44%), Gaps = 29/375 (7%)
Query: 675 LTKFQELKDVQDELRIKEN-------ELRALEEELAGLK-NTAEKYRQLKQQWEMKTEEA 726
+T ++K ++DE+ + ++ E + LEE ++ L N AE+ + K ++K +
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 727 DLL-QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
++ + +++ K ++EL+ LK+ +E ++ A+ + ++ E KM+ A+
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-----EQIADLQAQIAELKMQLAK- 1094
Query: 786 ERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE 845
+E EL+ A +LD + + + KK++E + + + +L+ + ++Q + E
Sbjct: 1095 -KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 846 AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND 905
+++ ++++E A +E K ++EVT K+ + + +A+ E+ + Q
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ--- 1210
Query: 906 SQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEA 965
++EL + + KR + + K+ + E + GQ + K +
Sbjct: 1211 ---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 966 GQRLQKLQEMKEKLGRNVNMRAMNVLTEAE-------ERYNDLMKKKRIVENDKSKILTT 1018
Q LQ E+ +N + + E E E +K + V + S++ T
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 1019 IEDLDQKKNQALNIA 1033
E L ++ Q LN++
Sbjct: 1328 QELLQEETRQKLNVS 1342
Score = 35.8 bits (81), Expect = 0.25
Identities = 34/145 (23%), Positives = 63/145 (43%), Gaps = 28/145 (19%)
Query: 177 KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
+K AA K++++K+ KLKEI +E+E Q ++ +++ R++E
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE-------- 1894
Query: 237 YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK--RKDKET-- 292
+ EE + + KLQ EL E + +A+ E+ L+ R+ ET
Sbjct: 1895 -----------EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1943
Query: 293 -----GGILRSLEDALAEAQRVNTK 312
G R +E+A + +T+
Sbjct: 1944 VPSRRSGGRRVIENADGSEEETDTR 1968
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 107 bits (268), Expect = 5e-23
Identities = 201/970 (20%), Positives = 395/970 (40%), Gaps = 158/970 (16%)
Query: 132 CSVGLNVNNPHFLIMQGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
C+ L + N + + ++ +L + + E+ + +E T+ + K K +E+K
Sbjct: 830 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 889
Query: 190 AKLKEIKTILEEEI---TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTK 246
++L E K +L+E++ T + +E R ++ + EI H + + ED
Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRG 945
Query: 247 VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
+ E K+M +++ L+E+L E + + L E E + ++ LED +
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK--------IKKLEDEILVM 997
Query: 307 QRVNTKSQSAFDLKKK-------NLACEESKRKELEK------NMVEDSKTLAAKEKEVK 353
N K L ++ NLA EE K K L K +M+ + + KE++ +
Sbjct: 998 DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057
Query: 354 KITDGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNEDGAEATLA--GQMMACKNDIS 410
+ + L E D E +A Q + L+ E+ +A LA +A KN+
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 411 KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK-RLKEKLE--AEMKK 467
K + ++ + + Q++L +++A K + R E LEA+K L++ L+ A ++
Sbjct: 1118 K---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 468 LNYEENKEESLL-----EKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
L + +E ++L E+ R + +++ + + +K + N ++N
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-- 1232
Query: 523 KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
K T +L AGE V G+ E E K++ + ++
Sbjct: 1233 ----------KQTLEKENADL-AGE--------LRVLGQAKQE-VEHKKKKLEAQVQELQ 1272
Query: 583 ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
++C E R N D VH +LQ +E V G +
Sbjct: 1273 SKCSDGERARAELN----DKVH----------KLQNEVESVTGMLNEAEG---------- 1308
Query: 643 KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD-VQDELRIKEN---ELRAL 698
+ + L DV AS+ ++ Q+ ++ +Q+E R K N +LR L
Sbjct: 1309 -----KAIKLAKDV---------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1348
Query: 699 EEELAGLKNTAEKYRQLKQQWE--MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
EEE L++ ++ + KQ E + T L +K + + E L+ KK ++
Sbjct: 1349 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1408
Query: 757 ETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERE----LKDAQKKLDCAKTKAD 806
E L E + A +K E +N+++ + + +R+ L+ Q+K D +
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 807 ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAK 863
S K +++ EA E E + + S + LE EA + E +++ AE +
Sbjct: 1469 NISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 864 NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK--------ELDH 915
+K+ V K E+ K K + Q +K + E+ + D++L+++ + +
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 916 NISKHKREAEDGAAKVSKMLKDYDW------------INAERHLFGQPNS---AYDFKTN 960
++ + E+ ++ + L +Y+ A++ L G D
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 961 NPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI 1019
+EA ++L+KLQ +MK+ + RA A + N+ KK + +E D ++ +
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--KKAKSLEADLMQLQEDL 1703
Query: 1020 EDLDQKKNQA 1029
++ + QA
Sbjct: 1704 AAAERARKQA 1713
Score = 103 bits (257), Expect = 1e-21
Identities = 148/737 (20%), Positives = 306/737 (41%), Gaps = 111/737 (15%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
E+ A+L + L+ E+ L E + K+ +++ LS Q LL E+T
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI---KLAKDVASLSSQLQDTQELLQEET 1335
Query: 246 --KVRSAEELKEMQDKVIKLQEELSEN-------DKKIKALNHEIEELEKRKDKETGGIL 296
K+ + +L++++++ LQ++L E ++ I LN ++ + K+K ++ +
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD-SKKKLQDFASTV 1394
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
+LE+ Q+ ++ K A K ++ + + ++ L +++
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
L E + + L A +++ +S+ + D AEA A + +++A EA
Sbjct: 1451 SNL----EKKQRKFDQLLAEEKN---ISSKYADERDRAEAE-AREKETKALSLARALEEA 1502
Query: 417 KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEE 476
+A+ +L+ + LK + ++ K+ LE KR E EMK EE ++E
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT-QLEELEDE 1561
Query: 477 SLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTS 536
+ +L RL+ +AL +F A + + R + L ++D
Sbjct: 1562 LQATEDAKL-----RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 537 ATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQN 596
AL A ++L + D E+ ++ R I L K+ A+
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKG----REEAIKQLRKLQAQ------------ 1660
Query: 597 LVGPDNVHVALSLVEYKPELQKAM---EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG 653
+ +++ EL+ A + +F T +N KK +L
Sbjct: 1661 ------------MKDFQRELEDARASRDEIFATA-----KENEKKAK----------SLE 1693
Query: 654 GDVFDPHGTLSGGARSQAASILTKFQELKD-----------VQDELRIKENELRALEEEL 702
D+ L+ R++ + L K +EL + +QDE R E + LEEEL
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 703 ----AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEET 758
++ +++ R+ QQ E + E ++ Q++ +QQ E
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE-------------- 1798
Query: 759 LKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
+ KE++ K E +++K K+ A E ++ +++++ + A++K +K+K ++
Sbjct: 1799 -RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 819 VEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAKNKESVNKAQEEV 875
++ I L++E+ ++ YK+Q E N +K + Q+E E + N+ + + +E
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 876 TKQKEVITAQDTVIKAK 892
T+ E + + +K+K
Sbjct: 1918 TESNEAMGREVNALKSK 1934
Score = 102 bits (255), Expect = 2e-21
Identities = 157/813 (19%), Positives = 347/813 (42%), Gaps = 89/813 (10%)
Query: 178 KIAAQKTIEKKEAKLKEIK---TILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
K A + EA+++E++ EE+T +++ K +++ L+ K E E+
Sbjct: 1187 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENAD--- 1242
Query: 235 IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG 294
+A + + K + K+++ +V +LQ + S+ ++ LN ++ +L+ + TG
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG- 1301
Query: 295 ILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKK 354
L +A +A ++ K++A S+ ++ ++ + E+++ ++++
Sbjct: 1302 ---MLNEAEGKAIKL-----------AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 355 ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
+ + ++LQ+ +++ EA ++H + ++ LS ++ ++ + + +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK--------KLQDFASTVEALEE 1399
Query: 415 EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV-------KRLKEKLEAEMKK 467
K+ Q ++++ Q+ + K A K++ + Q+ L+ + ++L LE + +K
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459
Query: 468 LNY---EENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKG 524
+ EE S R + R KET LAR K+ + N+ +K
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKA 1518
Query: 525 LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISAR 584
+ L+S KD EL +R ++ T + LE EL+ +++ +
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQ 1577
Query: 585 CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKR 644
+ + R +L D + E + +LQ+ + + T + A A K+
Sbjct: 1578 ALKGQFER---DLQARDEQNE-----EKRRQLQRQLH-EYETELEDERKQRALAAAAKKK 1628
Query: 645 IMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENELRALEEE 701
L GD+ D R +A L K Q ++KD Q EL + RA +E
Sbjct: 1629 -------LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE----DARASRDE 1677
Query: 702 LAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI-EESEETLK 760
+ EK + K+ EADL+Q + ++ + +++ D K+ + EE +L
Sbjct: 1678 IFATAKENEK--------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 761 NTKEIQ---RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQ 817
+Q R+ E + LE +++ + E + D +K A +A+ S ++ ++
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRK---ATQQAEQLSNELATERS 1785
Query: 818 EVEAITLELEELKREHTSYKQQLEAVNEAIKS-YESQIEVMAAEVAKNKESVNKAQEEVT 876
+ ++L+R++ + +L + A+KS ++S I + A++A+ +E V + E
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 877 KQKEVITAQDTVIKAKYAEVA-------KHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
+ + +D +K +V ++KEQ ++K+L + + + E++ A
Sbjct: 1846 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 930 KVSKMLKDYDWINAERHLFGQPNSAYDFKTNNP 962
K+ ++ D G+ +A K P
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSKLRGP 1938
Score = 95.1 bits (235), Expect = 3e-19
Identities = 188/933 (20%), Positives = 373/933 (39%), Gaps = 120/933 (12%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAE- 243
E+K L ++K E I+ +LK+E S E +K+ R++E S + L A+
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 244 -DTKVRSAEELKEMQDKVIKLQEELSEND---KKIKALNHEIEELEKRKDKETGG---IL 296
+ K++ A++ +E+Q + +L +E+++ + KKI+ L I +L++ D E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
+ D E + + T+ + D + A ++ R + E+ + K L ++E +
Sbjct: 1146 KQKRDLGEELEALKTELEDTLD----STATQQELRAKREQEVTVLKKAL---DEETRSHE 1198
Query: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAGQMMACKNDISKAQ 413
+ +++ + E L + F A L N+ E A LAG++ + +A+
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV----LGQAK 1254
Query: 414 TEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
E + + KL+ QEL++K ++ ++ ++ K Q +E+V + + E + KL
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 470 YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK---DPEKNWNRNCVKGLV 526
+ S L+ ++L ++ R K L + R + + D E +N + +
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 527 ASLISVKDTS------ATTALELVAGERLYNVVVDT---------------EVTGKKL-- 563
I + D+ A+T L G++ + ++ E T +L
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 564 ------------------LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHV 605
LE+ + K + IS++ A+ +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE---AREKETK 1491
Query: 606 ALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSG 665
ALSL E +A E ++ K+ K M V+ DV L
Sbjct: 1492 ALSLARALEEALEAKE----------ELERTNKML--KAEMEDLVSSKDDVGKNVHELEK 1539
Query: 666 GARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEE 725
R+ + +L++++DEL+ E+ LE + LK E R L+ + E E+
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEK 1597
Query: 726 ADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
LQ +L + KQ+ A KK +E + L+ + K E+ K+
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV--------------EAITLEL 826
+ + +REL+DA+ D A + KK K + ++ + LE
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 827 EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK---NKESVNKAQEEVTKQ----- 878
EEL E S A+ + + E++I + E+ + N E+++ + T+Q
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 879 KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI-SKHKREAEDGAAKVSKMLKD 937
E+ T + T K + A + + QN + + K+ E++ + SK K AK++++ +
Sbjct: 1778 NELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 938 YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNV---LTEA 994
+ E+ + D K + +K+ E ++ N R + L EA
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1896
Query: 995 EERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
EE + +R ++ + + + E + ++ N
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 84.0 bits (206), Expect = 8e-16
Identities = 179/896 (19%), Positives = 354/896 (39%), Gaps = 99/896 (11%)
Query: 204 TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKL 263
T + L+EER L+ V+ + + R Y+A + ++ + + ++ +KL
Sbjct: 779 TGVLAHLEEERD--LKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKL 836
Query: 264 QE----ELSENDKKIKALNHEIEELEKRKDK--ETGGILRSLEDALAEAQRVNTKSQSAF 317
+ L K + + + EE++ ++D+ +T + E+ L E ++ +++
Sbjct: 837 RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK 896
Query: 318 DLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQ 377
+L ++ L E E E+ V LAAK++E+++I + A E + L A +
Sbjct: 897 NLLQEQLQAETELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAER 952
Query: 378 QHFNAVSAGLSSN---EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
+ L E+ A L + + + I K + E + +E K +
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1012
Query: 435 AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESL---LEK-RRQLSRDIG 490
+ + + +++E + + +LK K E+ + +L KEE LEK +R+L D
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1072
Query: 491 RLKETYEALLARFPNLR-------------FAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
E L A+ L+ A D E N +K + + D
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1132
Query: 538 TTALELVA-----------GERLYNVVVDTEVTGKKLLERGEL--KRRYTIIPLNKISAR 584
E A GE L + + E T + EL KR + L K
Sbjct: 1133 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Query: 585 CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT--TFVCDNMDNAKKVAF- 641
+V + + + L E + ++A + T +N D A ++
Sbjct: 1193 ETRSHEAQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 642 ---DKRIMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENEL 695
+ + + L V + S G AR++ + K Q E++ V L E +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 696 RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
L +++A L + + ++L Q+ +T + + TKL+Q +EE ++L+ ++E
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQE---ETRQKLNVSTKLRQ-----LEEERNSLQDQLDEE 1362
Query: 756 EETLKN------TKEIQ-RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADAS 808
E +N T IQ +++K + + ++ E ++R K+ + + KA A
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 809 SKKMKEK---QQEVEAITLELE-------ELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
K K K QQE++ + ++L+ L+++ + Q L Y + +
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 859 AEVAKNKE----SVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
AE A+ KE S+ +A EE + KE + + ++KA+ ++ K+ + +
Sbjct: 1483 AE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-------VGKNV 1534
Query: 915 HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
H + K KR E ++ L++ E L ++ + N GQ + LQ
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEE-----LEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 975 MKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
E+ + L E E D K++ + K K+ ++DL+ + + A+
Sbjct: 1590 RDEQ-NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Score = 73.2 bits (178), Expect = 1e-12
Identities = 74/375 (19%), Positives = 168/375 (44%), Gaps = 29/375 (7%)
Query: 675 LTKFQELKDVQDELRIKEN-------ELRALEEELAGLK-NTAEKYRQLKQQWEMKTEEA 726
+T ++K ++DE+ + ++ E + LEE ++ L N AE+ + K ++K +
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 727 DLL-QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
++ + +++ K ++EL+ LK+ +E ++ A+ + ++ E KM+ A+
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-----EQIADLQAQIAELKMQLAK- 1094
Query: 786 ERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE 845
+E EL+ A +LD + + + KK++E + + + +L+ + ++Q + E
Sbjct: 1095 -KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 846 AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND 905
+++ ++++E A +E K ++EVT K+ + + +A+ E+ + Q
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ--- 1210
Query: 906 SQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEA 965
++EL + + KR + + K+ + E + GQ + K +
Sbjct: 1211 ---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 966 GQRLQKLQEMKEKLGRNVNMRAMNVLTEAE-------ERYNDLMKKKRIVENDKSKILTT 1018
Q LQ E+ +N + + E E E +K + V + S++ T
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 1019 IEDLDQKKNQALNIA 1033
E L ++ Q LN++
Sbjct: 1328 QELLQEETRQKLNVS 1342
Score = 34.7 bits (78), Expect = 0.56
Identities = 26/111 (23%), Positives = 50/111 (45%), Gaps = 19/111 (17%)
Query: 177 KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
+K AA K++++K+ KLKEI +E+E Q ++ +++ R++E
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE-------- 1894
Query: 237 YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR 287
+ EE + + KLQ EL E + +A+ E+ L+ +
Sbjct: 1895 -----------EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 107 bits (268), Expect = 5e-23
Identities = 201/970 (20%), Positives = 395/970 (40%), Gaps = 158/970 (16%)
Query: 132 CSVGLNVNNPHFLIMQGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
C+ L + N + + ++ +L + + E+ + +E T+ + K K +E+K
Sbjct: 823 CAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKH 882
Query: 190 AKLKEIKTILEEEI---TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTK 246
++L E K +L+E++ T + +E R ++ + EI H + + ED
Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRG 938
Query: 247 VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
+ E K+M +++ L+E+L E + + L E E + ++ LED +
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK--------IKKLEDEILVM 990
Query: 307 QRVNTKSQSAFDLKKK-------NLACEESKRKELEK------NMVEDSKTLAAKEKEVK 353
N K L ++ NLA EE K K L K +M+ + + KE++ +
Sbjct: 991 DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050
Query: 354 KITDGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNEDGAEATLA--GQMMACKNDIS 410
+ + L E D E +A Q + L+ E+ +A LA +A KN+
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 411 KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK-RLKEKLE--AEMKK 467
K + ++ + + Q++L +++A K + R E LEA+K L++ L+ A ++
Sbjct: 1111 K---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 468 LNYEENKEESLL-----EKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
L + +E ++L E+ R + +++ + + +K + N ++N
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN-- 1225
Query: 523 KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
K T +L AGE V G+ E E K++ + ++
Sbjct: 1226 ----------KQTLEKENADL-AGE--------LRVLGQAKQE-VEHKKKKLEAQVQELQ 1265
Query: 583 ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
++C E R N D VH +LQ +E V G +
Sbjct: 1266 SKCSDGERARAELN----DKVH----------KLQNEVESVTGMLNEAEG---------- 1301
Query: 643 KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD-VQDELRIKEN---ELRAL 698
+ + L DV AS+ ++ Q+ ++ +Q+E R K N +LR L
Sbjct: 1302 -----KAIKLAKDV---------------ASLSSQLQDTQELLQEETRQKLNVSTKLRQL 1341
Query: 699 EEELAGLKNTAEKYRQLKQQWE--MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
EEE L++ ++ + KQ E + T L +K + + E L+ KK ++
Sbjct: 1342 EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI 1401
Query: 757 ETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERE----LKDAQKKLDCAKTKAD 806
E L E + A +K E +N+++ + + +R+ L+ Q+K D +
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 807 ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAK 863
S K +++ EA E E + + S + LE EA + E +++ AE +
Sbjct: 1462 NISSKYADERDRAEA---EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 864 NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK--------ELDH 915
+K+ V K E+ K K + Q +K + E+ + D++L+++ + +
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 916 NISKHKREAEDGAAKVSKMLKDYDW------------INAERHLFGQPNS---AYDFKTN 960
++ + E+ ++ + L +Y+ A++ L G D
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 961 NPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI 1019
+EA ++L+KLQ +MK+ + RA A + N+ KK + +E D ++ +
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE--KKAKSLEADLMQLQEDL 1696
Query: 1020 EDLDQKKNQA 1029
++ + QA
Sbjct: 1697 AAAERARKQA 1706
Score = 103 bits (257), Expect = 1e-21
Identities = 148/737 (20%), Positives = 306/737 (41%), Gaps = 111/737 (15%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
E+ A+L + L+ E+ L E + K+ +++ LS Q LL E+T
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI---KLAKDVASLSSQLQDTQELLQEET 1328
Query: 246 --KVRSAEELKEMQDKVIKLQEELSEN-------DKKIKALNHEIEELEKRKDKETGGIL 296
K+ + +L++++++ LQ++L E ++ I LN ++ + K+K ++ +
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD-SKKKLQDFASTV 1387
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
+LE+ Q+ ++ K A K ++ + + ++ L +++
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEK----AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
L E + + L A +++ +S+ + D AEA A + +++A EA
Sbjct: 1444 SNL----EKKQRKFDQLLAEEKN---ISSKYADERDRAEAE-AREKETKALSLARALEEA 1495
Query: 417 KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEE 476
+A+ +L+ + LK + ++ K+ LE KR E EMK EE ++E
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT-QLEELEDE 1554
Query: 477 SLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTS 536
+ +L RL+ +AL +F A + + R + L ++D
Sbjct: 1555 LQATEDAKL-----RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 537 ATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQN 596
AL A ++L + D E+ ++ R I L K+ A+
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKG----REEAIKQLRKLQAQ------------ 1653
Query: 597 LVGPDNVHVALSLVEYKPELQKAM---EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG 653
+ +++ EL+ A + +F T +N KK +L
Sbjct: 1654 ------------MKDFQRELEDARASRDEIFATA-----KENEKKAK----------SLE 1686
Query: 654 GDVFDPHGTLSGGARSQAASILTKFQELKD-----------VQDELRIKENELRALEEEL 702
D+ L+ R++ + L K +EL + +QDE R E + LEEEL
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 703 ----AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEET 758
++ +++ R+ QQ E + E ++ Q++ +QQ E
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE-------------- 1791
Query: 759 LKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
+ KE++ K E +++K K+ A E ++ +++++ + A++K +K+K ++
Sbjct: 1792 -RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 819 VEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE---VAKNKESVNKAQEEV 875
++ I L++E+ ++ YK+Q E N +K + Q+E E + N+ + + +E
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 876 TKQKEVITAQDTVIKAK 892
T+ E + + +K+K
Sbjct: 1911 TESNEAMGREVNALKSK 1927
Score = 102 bits (255), Expect = 2e-21
Identities = 157/813 (19%), Positives = 347/813 (42%), Gaps = 89/813 (10%)
Query: 178 KIAAQKTIEKKEAKLKEIK---TILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
K A + EA+++E++ EE+T +++ K +++ L+ K E E+
Sbjct: 1180 KKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-LDKNKQTLEKENAD--- 1235
Query: 235 IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG 294
+A + + K + K+++ +V +LQ + S+ ++ LN ++ +L+ + TG
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG- 1294
Query: 295 ILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKK 354
L +A +A ++ K++A S+ ++ ++ + E+++ ++++
Sbjct: 1295 ---MLNEAEGKAIKL-----------AKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 355 ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
+ + ++LQ+ +++ EA ++H + ++ LS ++ ++ + + +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK--------KLQDFASTVEALEE 1392
Query: 415 EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV-------KRLKEKLEAEMKK 467
K+ Q ++++ Q+ + K A K++ + Q+ L+ + ++L LE + +K
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452
Query: 468 LNY---EENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKG 524
+ EE S R + R KET LAR K+ + N+ +K
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK-MLKA 1511
Query: 525 LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISAR 584
+ L+S KD EL +R ++ T + LE EL+ +++ +
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE-DELQATEDAKLRLEVNMQ 1570
Query: 585 CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKR 644
+ + R +L D + E + +LQ+ + + T + A A K+
Sbjct: 1571 ALKGQFER---DLQARDEQNE-----EKRRQLQRQLH-EYETELEDERKQRALAAAAKKK 1621
Query: 645 IMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENELRALEEE 701
L GD+ D R +A L K Q ++KD Q EL + RA +E
Sbjct: 1622 -------LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE----DARASRDE 1670
Query: 702 LAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI-EESEETLK 760
+ EK + K+ EADL+Q + ++ + +++ D K+ + EE +L
Sbjct: 1671 IFATAKENEK--------KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 761 NTKEIQ---RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQ 817
+Q R+ E + LE +++ + E + D +K A +A+ S ++ ++
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRK---ATQQAEQLSNELATERS 1778
Query: 818 EVEAITLELEELKREHTSYKQQLEAVNEAIKS-YESQIEVMAAEVAKNKESVNKAQEEVT 876
+ ++L+R++ + +L + A+KS ++S I + A++A+ +E V + E
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 877 KQKEVITAQDTVIKAKYAEVA-------KHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
+ + +D +K +V ++KEQ ++K+L + + + E++ A
Sbjct: 1839 AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 930 KVSKMLKDYDWINAERHLFGQPNSAYDFKTNNP 962
K+ ++ D G+ +A K P
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSKLRGP 1931
Score = 95.1 bits (235), Expect = 3e-19
Identities = 188/933 (20%), Positives = 373/933 (39%), Gaps = 120/933 (12%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAE- 243
E+K L ++K E I+ +LK+E S E +K+ R++E S + L A+
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 244 -DTKVRSAEELKEMQDKVIKLQEELSEND---KKIKALNHEIEELEKRKDKETGG---IL 296
+ K++ A++ +E+Q + +L +E+++ + KKI+ L I +L++ D E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
+ D E + + T+ + D + A ++ R + E+ + K L ++E +
Sbjct: 1139 KQKRDLGEELEALKTELEDTLD----STATQQELRAKREQEVTVLKKAL---DEETRSHE 1191
Query: 357 DGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAGQMMACKNDISKAQ 413
+ +++ + E L + F A L N+ E A LAG++ + +A+
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV----LGQAK 1247
Query: 414 TEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
E + + KL+ QEL++K ++ ++ ++ K Q +E+V + + E + KL
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 470 YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK---DPEKNWNRNCVKGLV 526
+ S L+ ++L ++ R K L + R + + D E +N + +
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 527 ASLISVKDTS------ATTALELVAGERLYNVVVDT---------------EVTGKKL-- 563
I + D+ A+T L G++ + ++ E T +L
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 564 ------------------LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHV 605
LE+ + K + IS++ A+ +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAE---AREKETK 1484
Query: 606 ALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSG 665
ALSL E +A E ++ K+ K M V+ DV L
Sbjct: 1485 ALSLARALEEALEAKE----------ELERTNKML--KAEMEDLVSSKDDVGKNVHELEK 1532
Query: 666 GARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEE 725
R+ + +L++++DEL+ E+ LE + LK E R L+ + E E+
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE--RDLQARDEQNEEK 1590
Query: 726 ADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
LQ +L + KQ+ A KK +E + L+ + K E+ K+
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV--------------EAITLEL 826
+ + +REL+DA+ D A + KK K + ++ + LE
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 827 EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK---NKESVNKAQEEVTKQ----- 878
EEL E S A+ + + E++I + E+ + N E+++ + T+Q
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 879 KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI-SKHKREAEDGAAKVSKMLKD 937
E+ T + T K + A + + QN + + K+ E++ + SK K AK++++ +
Sbjct: 1771 NELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 938 YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNV---LTEA 994
+ E+ + D K + +K+ E ++ N R + L EA
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEA 1889
Query: 995 EERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
EE + +R ++ + + + E + ++ N
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 84.0 bits (206), Expect = 8e-16
Identities = 179/896 (19%), Positives = 354/896 (39%), Gaps = 99/896 (11%)
Query: 204 TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKL 263
T + L+EER L+ V+ + + R Y+A + ++ + + ++ +KL
Sbjct: 772 TGVLAHLEEERD--LKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKL 829
Query: 264 QE----ELSENDKKIKALNHEIEELEKRKDK--ETGGILRSLEDALAEAQRVNTKSQSAF 317
+ L K + + + EE++ ++D+ +T + E+ L E ++ +++
Sbjct: 830 RNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK 889
Query: 318 DLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQ 377
+L ++ L E E E+ V LAAK++E+++I + A E + L A +
Sbjct: 890 NLLQEQLQAETELYAEAEEMRVR----LAAKKQELEEILHEMEARLEEEEDRGQQLQAER 945
Query: 378 QHFNAVSAGLSSN---EDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
+ L E+ A L + + + I K + E + +E K +
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005
Query: 435 AEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESL---LEK-RRQLSRDIG 490
+ + + +++E + + +LK K E+ + +L KEE LEK +R+L D
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDAS 1065
Query: 491 RLKETYEALLARFPNLR-------------FAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
E L A+ L+ A D E N +K + + D
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE 1125
Query: 538 TTALELVA-----------GERLYNVVVDTEVTGKKLLERGEL--KRRYTIIPLNKISAR 584
E A GE L + + E T + EL KR + L K
Sbjct: 1126 DLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Query: 585 CIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGT--TFVCDNMDNAKKVAF- 641
+V + + + L E + ++A + T +N D A ++
Sbjct: 1186 ETRSHEAQVQE--MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 642 ---DKRIMTRTVTLGGDVFDPHGTLSGG--ARSQAASILTKFQ-ELKDVQDELRIKENEL 695
+ + + L V + S G AR++ + K Q E++ V L E +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 696 RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
L +++A L + + ++L Q+ +T + + TKL+Q +EE ++L+ ++E
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQE---ETRQKLNVSTKLRQ-----LEEERNSLQDQLDEE 1355
Query: 756 EETLKN------TKEIQ-RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADAS 808
E +N T IQ +++K + + ++ E ++R K+ + + KA A
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 809 SKKMKEK---QQEVEAITLELE-------ELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
K K K QQE++ + ++L+ L+++ + Q L Y + +
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 859 AEVAKNKE----SVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
AE A+ KE S+ +A EE + KE + + ++KA+ ++ K+ + +
Sbjct: 1476 AE-AREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD-------VGKNV 1527
Query: 915 HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
H + K KR E ++ L++ E L ++ + N GQ + LQ
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEE-----LEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 975 MKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
E+ + L E E D K++ + K K+ ++DL+ + + A+
Sbjct: 1583 RDEQ-NEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Score = 73.2 bits (178), Expect = 1e-12
Identities = 74/375 (19%), Positives = 168/375 (44%), Gaps = 29/375 (7%)
Query: 675 LTKFQELKDVQDELRIKEN-------ELRALEEELAGLK-NTAEKYRQLKQQWEMKTEEA 726
+T ++K ++DE+ + ++ E + LEE ++ L N AE+ + K ++K +
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 727 DLL-QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
++ + +++ K ++EL+ LK+ +E ++ A+ + ++ E KM+ A+
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH-----EQIADLQAQIAELKMQLAK- 1087
Query: 786 ERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE 845
+E EL+ A +LD + + + KK++E + + + +L+ + ++Q + E
Sbjct: 1088 -KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 846 AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND 905
+++ ++++E A +E K ++EVT K+ + + +A+ E+ + Q
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ--- 1203
Query: 906 SQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEA 965
++EL + + KR + + K+ + E + GQ + K +
Sbjct: 1204 ---AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 966 GQRLQKLQEMKEKLGRNVNMRAMNVLTEAE-------ERYNDLMKKKRIVENDKSKILTT 1018
Q LQ E+ +N + + E E E +K + V + S++ T
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 1019 IEDLDQKKNQALNIA 1033
E L ++ Q LN++
Sbjct: 1321 QELLQEETRQKLNVS 1335
Score = 34.7 bits (78), Expect = 0.56
Identities = 26/111 (23%), Positives = 50/111 (45%), Gaps = 19/111 (17%)
Query: 177 KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
+K AA K++++K+ KLKEI +E+E Q ++ +++ R++E
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLE-------- 1887
Query: 237 YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR 287
+ EE + + KLQ EL E + +A+ E+ L+ +
Sbjct: 1888 -----------EAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 107 bits (267), Expect = 7e-23
Identities = 183/952 (19%), Positives = 385/952 (40%), Gaps = 119/952 (12%)
Query: 149 RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKI---AAQKTI------EKKEAKLKE 194
++ K + ++ ++ EE AG ++ + KK A Q+T+ E K L +
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTK 1026
Query: 195 IKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEEL 253
KT LE+++ L++E+ ++ ++ R++E L +A + + E+ K + E+L
Sbjct: 1027 AKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLE--GDLKLAQESTMDTENDKQQLNEKL 1084
Query: 254 KEMQDKVIKLQEELSEND-------KKIKALNHEIEELEK----------RKDKETGGIL 296
K+ + ++ LQ ++ + KKIK L IEELE+ + +K+ +
Sbjct: 1085 KKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKE----V 352
R LE+ + + + ++ KK A + R++LE++ ++ T AA K+ V
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSV 1204
Query: 353 KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKA 412
++ + + +LQ K + + + N +++ + + A+A ++ +S+
Sbjct: 1205 AELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSK-AKANFEKMCRTLEDQLSEI 1263
Query: 413 QTEAKQAQMKLKHAQ--------------QELKNKQAEVKKMDSGYRKDQEALEAVKRLK 458
+T+ ++ Q + ++L K A V ++ G + + +E +KR
Sbjct: 1264 KTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL 1323
Query: 459 EKLEAEMKKLNYEENKEESLLEKRRQLSR-DIGRLKETYEALLARFPNLRFAYKDPEKN- 516
E EE K +S L Q +R D L+E YE L+
Sbjct: 1324 E-----------EETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV 1372
Query: 517 --WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYT 574
W + +++ A L E V + +K +R + +
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL 1432
Query: 575 IIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMD 634
+I + + +A CIA L Q E + EL+ + + + +
Sbjct: 1433 MIDVERSNAACIA---LDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVK 1489
Query: 635 NAKKVAFD--KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKE 692
NA + + D + + L ++ D ++ G + EL+ V+ +L ++
Sbjct: 1490 NAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKH--------IHELEKVKKQLDHEK 1541
Query: 693 NELR-ALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKT 751
+EL+ +LEE A L++ K +++ + E D ++ EELD LK+
Sbjct: 1542 SELQTSLEEAEASLEHEEGKILRIQLELNQVKSEID--------RKIAEKDEELDQLKRN 1593
Query: 752 IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKK 811
E++++T + + ++ ++ KM E +L + + +L+ A +A + +
Sbjct: 1594 HLRVVESMQSTLDAEIRSRNDALRIKKKM-------EGDLNEMEIQLNHANRQAAEALRN 1646
Query: 812 MKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKA 871
++ Q ++ L L++ R K+QL V ++++E + A + + + A
Sbjct: 1647 LRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMA 1706
Query: 872 QEEVTKQKEVI----TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDG 927
++E+ E + T ++I K + + + ++E + K K+ D
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDA 1766
Query: 928 AAKVSKMLKDYDW-INAERHLFGQPNSAYDFKTNNP-------KEAGQRLQKLQEMKEKL 979
A ++ K+ D + ER + D + K +++QKL+ +L
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1826
Query: 980 GRNV------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
V N+ A+ L + E R +L + E D+ IL ++DL K
Sbjct: 1827 ESEVESEQKHNVEAVKGLRKHERRVKELTYQ---TEEDRKNIL-RLQDLVDK 1874
Score = 106 bits (264), Expect = 2e-22
Identities = 193/856 (22%), Positives = 355/856 (41%), Gaps = 114/856 (13%)
Query: 154 LNMKPPEILSMIEEAAGTRMYEYKKIA-AQKTIEKKEAKLKEIKTILEEEITPTIQKLKE 212
L K E+ + IEE E A A+K +L+EI LEE T +++
Sbjct: 1108 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1167
Query: 213 ERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSE 269
+ E+QK+ R++E + + A L + D+ E++ +Q KL++E SE
Sbjct: 1168 NKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSE 1227
Query: 270 NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEES 329
+I L +E + K K + R+LED L+E + TK + +++ L E S
Sbjct: 1228 LKMEINDLASNMETVSKAK-ANFEKMCRTLEDQLSE---IKTKEE-----EQQRLINELS 1278
Query: 330 KRK-ELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS 388
+K L E S+ L K+ V +++ G A + + L
Sbjct: 1279 AQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL--------------- 1323
Query: 389 SNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQ 448
E A++TLA + + ++D + + ++ Q Q+ + +EV + + Y D
Sbjct: 1324 EEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETD- 1382
Query: 449 EALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRF 508
A++ + L+E + ++L E E++ K L + RL+ E L+
Sbjct: 1383 -AIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA 1441
Query: 509 AYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGE 568
A +K RN K L ++T A EL A ++ + + TE+ K
Sbjct: 1442 ACIALDKK-QRNFDKVLAEWKQKYEETQA----ELEASQK-ESRSLSTELFKVKNAYEES 1495
Query: 569 LKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVH----VALSLVEYKPELQKAMEFVF 624
L T+ NK + I+ T ++A+ G ++H V L K ELQ ++E
Sbjct: 1496 LDHLETLKRENKNLQQEISDLTEQIAE---GGKHIHELEKVKKQLDHEKSELQTSLEEAE 1552
Query: 625 -------GTTFVCDNMDNAKKVAFDKRIMTRTVTLGG-------DVFDPHGTLSGGARSQ 670
G N K D++I + L V TL RS+
Sbjct: 1553 ASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSR 1612
Query: 671 AASILTKFQELKDVQDELRIKENEL-RALEEELAGLKNTAEKYRQ--------------L 715
++ K ++++ +E+ I+ N R E L L+NT + L
Sbjct: 1613 NDALRIK-KKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDL 1671
Query: 716 KQQWEMKTEEADLLQTKLQQ--SSYHK--------QQEELDALKKT--IEESEETLKNTK 763
K+Q M A+L+Q ++++ +S + +QE LDA ++ + +L NTK
Sbjct: 1672 KEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTK 1731
Query: 764 EIQRKAEEKYEVLENKM-------KNAEAERERELKDAQKKLDCAKTKADASS---KKMK 813
+K E ++ +M +NAE + ++ + DA + K + D S+ + K
Sbjct: 1732 ---KKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
Query: 814 EKQQEVEAITLELEELKR-EHTSYKQQLEAVNEAIKSYESQIEVMA---AEVAKNKESVN 869
+Q V+ + L L+E ++ K+Q++ + ++ ES++E E K
Sbjct: 1789 NMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHE 1848
Query: 870 KAQEEVTKQ-----KEVITAQDTV------IKAKYAEVAKHKEQNNDSQLKIKELDHNIS 918
+ +E+T Q K ++ QD V +KA + + +EQ+N + K ++L H +
Sbjct: 1849 RRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELE 1908
Query: 919 KHKREAEDGAAKVSKM 934
+ K A+ ++V+K+
Sbjct: 1909 EAKERADIAESQVNKL 1924
Score = 98.6 bits (244), Expect = 3e-20
Identities = 183/916 (19%), Positives = 358/916 (39%), Gaps = 168/916 (18%)
Query: 174 YEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRL 233
++ K + EK+ A +KE +EE+ T K KE LE +K++ ++ + L
Sbjct: 838 FKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKE-----LE-EKMVTLMQEKNDL 891
Query: 234 YIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETG 293
+ Q AE + AEE D++IK + +L + KIK + E+ E+ + E
Sbjct: 892 QLQVQ---AEADALADAEE---RCDQLIKTKIQL---EAKIKEVTERAED-EEEINAELT 941
Query: 294 GILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
R LED +E ++ + +K E+K K L + M +T+A KE K
Sbjct: 942 AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1001
Query: 354 KITDGLHALQEASNKDAEALAAAQQHFNAVSAG---LSSNEDGAEATLAGQMMAC----- 405
ALQEA + + L + N ++ L D E +L + C
Sbjct: 1002 -------ALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLER 1054
Query: 406 -----KNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQE-ALEAVKRLKE 459
+ D+ AQ + + ++LK K+ E+ + +Q A++ K++KE
Sbjct: 1055 AKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE 1114
Query: 460 KLEAEMKKLNYEENKEESLLEKRRQLSRDIGR-LKETYEALLARFPNLRFAYKDPEKNWN 518
L+A +++L E E + K + D+ R L+E E L
Sbjct: 1115 -LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL------------------- 1154
Query: 519 RNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRRYTI 575
++ T+ ++ ++ E +K+ LE L+ T
Sbjct: 1155 --------------EEAGGATSAQIEMNKK-------REAEFQKMRRDLEESTLQHEATA 1193
Query: 576 IPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDN 635
L K A +A ++ +L V+ K E +K+ E + NM+
Sbjct: 1194 AALRKKHADSVAELGEQID-----------SLQRVKQKLEKEKS-ELKMEINDLASNMET 1241
Query: 636 AKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENEL 695
K + M RT+ Q + I TK +E + + +EL ++ L
Sbjct: 1242 VSKAKANFEKMCRTL-----------------EDQLSEIKTKEEEQQRLINELSAQKARL 1284
Query: 696 --------RALEEELA-------GLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHK 740
R L+E+ A G + ++ +LK+Q E +T+ L LQ + +
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH-- 1342
Query: 741 QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDC 800
+ D L++ EE +E + KA + K + +R EL++A+KKL
Sbjct: 1343 ---DCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL-- 1397
Query: 801 AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLE----------AVNEAIKSY 850
++++++ ++ VEA+ + L++ + ++E A A+
Sbjct: 1398 --------AQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKK 1449
Query: 851 ESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKH----KEQNNDS 906
+ + + AE + E E K+ ++ + +K Y E H K +N +
Sbjct: 1450 QRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNL 1509
Query: 907 QLKIKELD----------HNISKHKREAEDGAAKVSKMLKDYD--WINAERHLFGQPNSA 954
Q +I +L H + K K++ + +++ L++ + + E +
Sbjct: 1510 QQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLEL 1569
Query: 955 YDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSK 1014
K+ ++ ++ ++L ++K R V + E R ND ++ K+ +E D ++
Sbjct: 1570 NQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSR-NDALRIKKKMEGDLNE 1628
Query: 1015 ILTTIEDLDQKKNQAL 1030
+ + +++ +AL
Sbjct: 1629 MEIQLNHANRQAAEAL 1644
Score = 77.4 bits (189), Expect = 8e-14
Identities = 157/754 (20%), Positives = 320/754 (42%), Gaps = 104/754 (13%)
Query: 184 TIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE-HLSRLYIA---YQF 239
++++ + KL++ K+ L+ EI ++ + ++K+ R +E LS + Q
Sbjct: 1213 SLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQR 1272
Query: 240 LLAEDT--KVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILR 297
L+ E + K R E E ++ + +S+ + +A +IEEL+++ ++ET
Sbjct: 1273 LINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEET----- 1327
Query: 298 SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITD 357
+ LA A + ++ DL ++ E+ + EL++ M + + +A + K TD
Sbjct: 1328 KAKSTLAHALQ---SARHDCDLLREQYEEEQEAKAELQRGMSKANSEVA--QWRTKYETD 1382
Query: 358 GLHA---LQEASNKDAEALAAAQQHFNAVS---AGLSSNEDGAEATLAGQMM-------A 404
+ L+EA K A+ L A++H AV+ A L + + + M+ A
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAA 1442
Query: 405 C------KNDISKAQTEAKQ----AQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAV 454
C + + K E KQ Q +L+ +Q+E ++ E+ K+ + Y + + LE +
Sbjct: 1443 CIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETL 1502
Query: 455 KRLKEKLEAEMKKLNY---EENKEESLLEK-RRQLSRDIGRLKETYEALLARFPNLRFAY 510
KR + L+ E+ L E K LEK ++QL + L+ + E A +
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKI 1562
Query: 511 KDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNV-----VVDTEVTGKKLLE 565
+ N+ VK + I+ KD L+ + L V +D E+ +
Sbjct: 1563 LRIQLELNQ--VKSEIDRKIAEKDEE----LDQLKRNHLRVVESMQSTLDAEIRSRNDAL 1616
Query: 566 RGELKRRYTI----IPLNKISARCIAPETLRVAQN---------------LVGPDNVHVA 606
R + K + I LN + + A E LR +N + G D++
Sbjct: 1617 RIKKKMEGDLNEMEIQLNHANRQ--AAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQ 1674
Query: 607 LSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
L++VE + L +A + + + +K+A ++ ++ + + + T
Sbjct: 1675 LAMVERRANLMQAEVEELRASL--ERTERGRKMA-EQELLDASERV--QLLHTQNTSLIN 1729
Query: 667 ARSQAASILTKFQ-ELKDVQDELRIKENELRA-------LEEELAGLKNTAEKYRQLKQQ 718
+ + + +++ Q E++D+ E R E + + + EEL ++T+ ++K+
Sbjct: 1730 TKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN 1789
Query: 719 WE-------MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE----ETLKNTKEIQR 767
E ++ +EA+ L K + K + + L+ +E + E +K ++ +R
Sbjct: 1790 MEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHER 1849
Query: 768 KAEEKYEVLENKMKNAEAERERELKD-AQKKLDCAKTKADASSKKMKEKQQEVEAITLEL 826
+ +E E KN R ++L D Q K+ K +A+ + ++ + + EL
Sbjct: 1850 RVKELTYQTEEDRKN--ILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHEL 1907
Query: 827 EELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860
EE K + Q+ + +KS E +V++ E
Sbjct: 1908 EEAKERADIAESQVNKLR--VKSREVHTKVISEE 1939
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 106 bits (264), Expect = 2e-22
Identities = 181/784 (23%), Positives = 336/784 (42%), Gaps = 88/784 (11%)
Query: 182 QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL 241
+KT+E+ E +++ K L + L+ +S L + + E RL A +
Sbjct: 285 RKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVH 344
Query: 242 AEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLED 301
++ + E+ M + + + E + + K KAL IE KD + + R L D
Sbjct: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIE----MKDSKISSMERGLRD 400
Query: 302 ALAEAQRVNTKSQSAFDLKKKNLACEESKRKELE-------KNMVEDSKT-LAAKE---K 350
E Q + KS A +++ EE K+ E+ KN VE K L++KE +
Sbjct: 401 LEEEIQML--KSNGALSTEERE---EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE 455
Query: 351 EVKKITDGLHA-----LQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMAC 405
E+KK GL A QE S KD E LA Q ++ S ++ E L + A
Sbjct: 456 ELKKKAAGLQAEIGQVKQELSRKDTELLAL-QTKLETLTNQFSDSKQHIEV-LKESLTAK 513
Query: 406 KNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEM 465
+ + QTE +++L+ + L K +++ D K +A E + LK+ L+ +
Sbjct: 514 EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ--DMAEEKGTQAGE-IHDLKDMLDVKE 570
Query: 466 KKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGL 525
+K+N + K E+L E+ R + + LKE ++L A N A E+ +
Sbjct: 571 RKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEK--ERT 628
Query: 526 VASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL-LERGELKRRYTIIPLNKISAR 584
+ L +D E E + N D + +K+ L +G+L + + K A
Sbjct: 629 IERLKEQRDRD-----EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHAS 683
Query: 585 CIAPETLRVAQNLVGPDNVHVAL-----SLVEYKPELQKAMEFVFGTTFVCDNMDNAKKV 639
+A L+ L + +AL ++ + +L+KA E + D + +
Sbjct: 684 SLASSGLKKDSRL---KTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHL 740
Query: 640 AFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALE 699
+R +TR + S A+++ +L + LK+V++E K+ ++ LE
Sbjct: 741 ---EREITR-----------YKDESSKAQAEVDRLL---EILKEVENEKNDKDKKIAELE 783
Query: 700 EELAGLKNTAEKYRQL--KQQWEMKTEEADLLQTKLQQSSYHKQQEEL-DALKK---TIE 753
+ +K+ +K L K+Q E K L + + ++ + + ++L D+L+K IE
Sbjct: 784 RQ---VKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840
Query: 754 ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQK---KLDCAKTKADASSK 810
E EE L+ + +I + E E+ NAE + E L +K +L+ K K ++ +
Sbjct: 841 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900
Query: 811 KMKEKQQEVEAITLELEELKREHTSYKQQ--LEAVNE--------AIKSYESQIEVMAAE 860
+ EK+ + + E + E KQ+ L A++E + S + + + A
Sbjct: 901 SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 960
Query: 861 VAKNKESVNKAQEEVTKQKEVITA---QDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNI 917
+ + K+ + + ++ T+ + + A +D K+ ++ HK + + ELD N
Sbjct: 961 LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 1020
Query: 918 SKHK 921
SK K
Sbjct: 1021 SKLK 1024
Score = 83.6 bits (205), Expect = 1e-15
Identities = 191/890 (21%), Positives = 371/890 (41%), Gaps = 167/890 (18%)
Query: 182 QKTIEKKEAKLKEIKTILEEEITPTIQK---LKEERSSYL-----EYQKVMREIEHLSRL 233
+K +E KE+KL ++ +P ++K L+++ +S + +Y+ V E +H+
Sbjct: 169 RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMT 228
Query: 234 YIAYQF----------LLAEDTKVRSAE----ELKEMQDKVIKLQEELSENDKKIKALNH 279
A Q L +D+ R+ E EL E + +L E K++ L
Sbjct: 229 IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE--ENFQRLHAEHERQAKELFLLRK 286
Query: 280 EIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKR-KELEKNM 338
+EE+E R + + + E + + +K SA ++ + E ++R E E ++
Sbjct: 287 TLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDH---ERTRRLAEAEMHV 343
Query: 339 VEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATL 398
L KEKE + + +H E + D+ A Q + +SS E G L
Sbjct: 344 HHLESLLEQKEKENSMLREEMHRRFENA-PDSAKTKALQTVIEMKDSKISSMERGLR-DL 401
Query: 399 AGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLK 458
++ K++ TE ++ +MK Q EV + S + K++ V++LK
Sbjct: 402 EEEIQMLKSN-GALSTEEREEEMK-----------QMEVYRSHSKFMKNK-----VEQLK 444
Query: 459 EKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWN 518
E+L ++ + + K L + Q+ +++ R AL + L + D +++
Sbjct: 445 EELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH-- 502
Query: 519 RNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPL 578
++ L SL + + +A ++ TEV +L L+ + T++
Sbjct: 503 ---IEVLKESLTAKEQRAA---------------ILQTEVDALRL----RLEEKETMLNK 540
Query: 579 NKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKK 638
+ +A E A +H +++ K ++ ++N ++
Sbjct: 541 KTKQIQDMAEEKGTQA------GEIHDLKDMLDVKERKVNVLQ---------KKIENLQE 585
Query: 639 VAFDKR-----IMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD-ELRIKE 692
DK + R +L D + L+ + A T + LK+ +D + R K+
Sbjct: 586 QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT-IERLKEQRDRDEREKQ 644
Query: 693 NELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTI 752
E+ +++L LK EK L Q ++ +EA LL K SS + D+ KT+
Sbjct: 645 EEIDNYKKDLKDLK---EKVSLL--QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 699
Query: 753 EESEETLKNTKEIQRKAEEKYEVLENKMKNA-----EAERERELKDAQKKLDCAKTK-AD 806
E + +++K EE + +E+++K A EA E+ D + L+ T+ D
Sbjct: 700 EIA---------LEQKKEECLK-MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 749
Query: 807 ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKE 866
SSK Q EV+ + L+E++ E +++ + +K +NK+
Sbjct: 750 ESSK----AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKD-------------QNKK 792
Query: 867 SVN-KAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQN-NDSQLKIKELDHNISKHKREA 924
N K +E+V K+K A+ E A+ +E N NDS ++++ R+
Sbjct: 793 VANLKHKEQVEKKK----------SAQMLEEARRREDNLNDSSQQLQD-------SLRKK 835
Query: 925 EDGAAKVSKMLKDYDWINAERHL-FGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV 983
+D ++ + L++ I AER + Q SA +TN K+ + L ++++K++L
Sbjct: 836 DDRIEELEEALRESVQITAEREMVLAQEESA---RTNAEKQVEELLMAMEKVKQEL---E 889
Query: 984 NMRA-----MNVLTEAEERYNDLMKKKR-----IVENDKSKILTTIEDLD 1023
+M+A L E E +L ++R ++E + +L I + D
Sbjct: 890 SMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD 939
Score = 76.3 bits (186), Expect = 2e-13
Identities = 85/409 (20%), Positives = 185/409 (45%), Gaps = 71/409 (17%)
Query: 680 ELKDVQDELRIKENELRALEEELAGLKNTAEKYRQ----LKQQWEMKTEEADLLQTKLQQ 735
E+ V+ EL K+ EL AL+ +L L N +Q LK+ K + A +LQT
Sbjct: 467 EIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQT---- 522
Query: 736 SSYHKQQEELDALKKTIEESEETL-KNTKEIQRKAEEKYEVLE--NKMKNAEAERERELK 792
E+DAL+ +EE E L K TK+IQ AEEK + +K+ +ER++
Sbjct: 523 --------EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 574
Query: 793 DAQKKLDCAKTKADASSKKMKEKQQEVEAI------------TLE---------LEELK- 830
QKK++ + + K+M ++ V+++ TLE +E LK
Sbjct: 575 VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKE 634
Query: 831 ---REHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDT 887
R+ +++++ + +K + ++ ++ ++++ + S+ +E + +D+
Sbjct: 635 QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 888 VIKAKYAEVAKHKEQ--NNDSQLK------------------IKELDHNISKHKREAEDG 927
+K + + KE+ +SQLK I+ L+ I+++K E+
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 754
Query: 928 AAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRA 987
A+V ++L+ + E++ + + + + + + L+ +++++K ++
Sbjct: 755 QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKK-------KS 807
Query: 988 MNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQK 1036
+L EA R ++L + +++ K IE+L++ +++ I ++
Sbjct: 808 AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER 856
Score = 63.5 bits (153), Expect = 1e-09
Identities = 84/441 (19%), Positives = 195/441 (44%), Gaps = 71/441 (16%)
Query: 668 RSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEAD 727
+ +A+ I ++ + VQ+E + + ++AL++EL ++ + ++Q + A+
Sbjct: 202 KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261
Query: 728 LLQTKLQQ--SSYHKQQEELDALKKTIEESE---ETLKNTKEIQRKAEEK-YEVLENKMK 781
L + Q+ + + +Q +EL L+KT+EE E ET K T + ++ +K E+L++K
Sbjct: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 321
Query: 782 NAEA-----ERERELKDAQKKL-----------------------------DCAKTKA-- 805
+A+A ER R L +A+ + D AKTKA
Sbjct: 322 SAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQ 381
Query: 806 ----------DASSKKMKEKQQEVEAI-------TLELEELKREHTSYKQQLEAVNEAIK 848
+ + +++ ++E++ + T E EE ++ Y+ + + ++
Sbjct: 382 TVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVE 441
Query: 849 SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQL 908
+ ++ A+ + K+ Q E+ + K+ ++ +DT + A ++ Q +DS+
Sbjct: 442 QLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ 501
Query: 909 KIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQR 968
I+ L +++ ++ A +V + + E L + D +AG+
Sbjct: 502 HIEVLKESLTAKEQRAAILQTEVDALRLRLE--EKETMLNKKTKQIQDMAEEKGTQAGE- 558
Query: 969 LQKLQEMKEKLGRNVNMRAMNV------LTEAEERYNDLMKKKRIVENDKSK---ILTTI 1019
+ L++M + R VN+ + L + E++ + L ++ + ++ D + LTT+
Sbjct: 559 IHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 618
Query: 1020 EDLDQKKNQALNIAWQKVNKD 1040
E+ +K + + ++ ++D
Sbjct: 619 EEALAEKERTIERLKEQRDRD 639
Score = 52.4 bits (124), Expect = 3e-06
Identities = 83/409 (20%), Positives = 162/409 (39%), Gaps = 54/409 (13%)
Query: 120 VNANNTRVQDLFCSVGLNVNNPH----FLIMQGRITKVLNMKPPEILSMIEEAAGTRMYE 175
+N ++QD+ G H L ++ R VL K + + +
Sbjct: 538 LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSL 597
Query: 176 YKKIAAQKTIEKKEAKLKEIKTILEEEITP---TIQKLKEERSSYLEYQKVMREIEHLSR 232
+++ K+++ T LEE + TI++LKE+R + ++ EI++ +
Sbjct: 598 KERV---KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR--DEREKQEEIDNYKK 652
Query: 233 LYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK---RKD 289
+LK++++KV LQ +LSE + + L L +KD
Sbjct: 653 -------------------DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693
Query: 290 KETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKE 349
L++LE AL + + K +S LKK + A E++ E S + E
Sbjct: 694 SR----LKTLEIALEQKKEECLKMES--QLKKAHEAALEARASP------EMSDRIQHLE 741
Query: 350 KEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDI 409
+E+ + D Q ++ E L + N ++ E + Q N
Sbjct: 742 REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAE----LERQVKDQNKKVANLK 797
Query: 410 SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQ---EALEAVKRLKEKLEAEMK 466
K Q E K++ L+ A++ N +++ RK E LE R ++ AE +
Sbjct: 798 HKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAERE 857
Query: 467 KLNYEENKEESLLEKR-RQLSRDIGRLKETYEALLARFPNLRFAYKDPE 514
+ +E + EK+ +L + ++K+ E++ A+ + + + + E
Sbjct: 858 MVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 906
Score = 49.3 bits (116), Expect = 2e-05
Identities = 69/358 (19%), Positives = 157/358 (43%), Gaps = 38/358 (10%)
Query: 680 ELKDVQDELRIKENELRALEEELAGLKNTAEKY--RQLKQQWEMKTEEADLLQTKLQQSS 737
+LK+V E + ++ E +L+ N+ + + +LK++ ++ +EA + +Q
Sbjct: 157 QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQ-- 214
Query: 738 YHKQQEELDALKKTIEESEETLKNTKEIQRKAEEK----------YEVLENKMKNAEAER 787
Y QEE ++ TI+ ++ L+ +++ + ++ E+ E + AE
Sbjct: 215 YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEH 274
Query: 788 ERE----------LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
ER+ L++ + +++ K +A + +K+ + +++ L + + +H +
Sbjct: 275 ERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTR 334
Query: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVA 897
+ EA + ES +E E + +E +++ E + A TVI+ K ++++
Sbjct: 335 RLAEA-EMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT-KALQTVIEMKDSKIS 392
Query: 898 KHKEQNNDSQLKIKELDHN--ISKHKREAEDGAAKV----SKMLKDYDWINAERHLFGQP 951
+ D + +I+ L N +S +RE E +V SK +K N L +
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMK-----NKVEQLKEEL 447
Query: 952 NSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVE 1009
+S K+A ++ ++K++L R + + + T+ E N K+ +E
Sbjct: 448 SSKEAQWEELKKKAAGLQAEIGQVKQELSRK-DTELLALQTKLETLTNQFSDSKQHIE 504
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 106 bits (264), Expect = 2e-22
Identities = 186/895 (20%), Positives = 367/895 (41%), Gaps = 135/895 (15%)
Query: 166 EEAAGTRMYEYKKIAAQKTIEKKE----------AKLKEIKTILEEEITPTIQKLKEERS 215
EE + + +K+ A+ I+K E +K + K ++E+ I +L EE
Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020
Query: 216 SYLEYQKVMREIE--------HLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEEL 267
K+ + E L + Q L E K + E ++QD++ +LQ ++
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL--EKAKRKLDGETTDLQDQIAELQAQI 1078
Query: 268 SENDKKIKALNHEIEELEKRKDKETGG------ILRSLEDALAEAQRVNTKSQSAFDLKK 321
E ++ E++ R D ET ++R L+ +AE Q + +S+ A K
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE-DFESEKASRNKA 1137
Query: 322 KNLACEESKRKELEKNMVEDSKTLAAKEKEVK-----KITDGLHALQEAS-NKDAEALAA 375
+ + S+ E K +ED+ A ++E++ ++ + AL+E + N +A+
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197
Query: 376 AQQHFNAVS-------------AGLSSNEDGAEATLAGQMMACKNDI-SKAQTEAKQAQM 421
Q+H A+ A L N+ G E + +AC+ + + + E++ +
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETD--NKELACEVKVLQQVKAESEHKRK 1255
Query: 422 KLKHAQQELKNKQAEVKKMD----SGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEES 477
KL QEL K +E ++ K Q L+ V L E+ E + K + ES
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315
Query: 478 LLEKRRQLSRDIGRLKETYEALLARFP---NLRFAYKDPEKNWNRNCVKGLVASLISVKD 534
L+ ++L ++ R K + + + N ++ E+ +N K ++A + D
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLAD 1375
Query: 535 TSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVA 594
T +L E L E KKLL+ E + ++ + +A + L
Sbjct: 1376 TKKKVDDDLGTIESL-------EEAKKKLLKDAEALSQ-------RLEEKALAYDKLEKT 1421
Query: 595 QNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGG 654
+N + + + + L + V N++ +K FD+ ++ ++
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQ--------------VASNLEKKQK-KFDQ-LLAEEKSISA 1465
Query: 655 DVFDPHGTLSGGAR---SQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEK 711
+ AR ++A S+ +E + ++E + +LRA E+L K+ K
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGK 1525
Query: 712 Y--------RQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELD--ALKKTIEESEETLKN 761
R L+QQ E + + L+ +LQ + K + E++ A+K E +T
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR-- 1583
Query: 762 TKEIQRKAEEKYEVLENKMKNAEAERERE-----------------LKDAQKKLDCAKTK 804
+ EEK +L +++ EAE E E LKD + +++ A
Sbjct: 1584 ----DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 805 ADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
D K++++ Q +++ ELEE + Q + + +KS E++I + E+A +
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 865 KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREA 924
+ + A++E + + IT + A ++ + +I +L+ + + +
Sbjct: 1700 ERARRHAEQERDELADEITNSASGKSALL-------DEKRRLEARIAQLEEELEEEQSNM 1752
Query: 925 EDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
E + K D +NAE L + ++A K++N ++ +R K E+K KL
Sbjct: 1753 ELLNDRFRKTTLQVDTLNAE--LAAERSAAQ--KSDNARQQLERQNK--ELKAKL 1801
Score = 101 bits (251), Expect = 5e-21
Identities = 158/784 (20%), Positives = 327/784 (41%), Gaps = 95/784 (12%)
Query: 180 AAQKTIEKKEAKLKEIKTILEEEIT---PTIQKLKEERSSYLEYQKVMREIEHLSRLY-- 234
A Q+ K+E ++ E+K LEEE IQ +++ ++ LE ++ ++E R
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALE--ELSEQLEQAKRFKAN 1221
Query: 235 --------------IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDK-------K 273
+A + + + K S + K++ +V +L ++SE D+ K
Sbjct: 1222 LEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281
Query: 274 IKALNHEIEELEKR-KDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKK-NLAC----- 326
L +E++ + ++ E GI + + A E+Q +T+ + ++K NL+
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 327 -------------EESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNK---DA 370
EE RK LEK ++ LA +K+V + +L+EA K DA
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 371 EALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQEL 430
EAL+ + L ++ + L +D++ +Q L+ Q++
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQEL--------DDLTVDLDHQRQVASNLEKKQKKF 1453
Query: 431 KNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIG 490
AE K + + Y ++++ EA R E E K L+ EE+L E + + R
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAR-----EKETKALSLARALEEAL-EAKEEFERQNK 1507
Query: 491 RLKETYEALLARFPNLRFAYKDPEKNWN--RNCVKGLVASLISVKDT-SATTALELVAGE 547
+L+ E L++ ++ + EK+ V+ + L ++D AT +L
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 548 RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
+ + E + E+ E K+R I + ++ A E R + L + +
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL---EDERKQRALAVASKKKMEI 1624
Query: 608 SLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD-KRIMTRTVTLGGDVFDPHGTLSGG 666
L + + +++ A + V + + D +R + ++F
Sbjct: 1625 DLKDLEAQIEAANK---ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681
Query: 667 ARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTA-----EKYR------QL 715
+S A IL +EL + R E E L +E+ + EK R QL
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 716 KQQWEMKTEEADLLQTKLQQSSYH------KQQEELDALKKTIEESEETLKNTKEIQRKA 769
+++ E + +LL + ++++ + E A +K+ ++ + KE++ K
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1801
Query: 770 EEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEEL 829
+E +++K K + E ++ +++L+ + A++K ++ +++++ I +++E+
Sbjct: 1802 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDE 1861
Query: 830 KREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEV---TKQKEVITAQD 886
+R YK+Q+E N +K + Q+E E + S K Q E+ T+ E ++ +
Sbjct: 1862 RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921
Query: 887 TVIK 890
+ +K
Sbjct: 1922 STLK 1925
Score = 92.8 bits (229), Expect = 2e-18
Identities = 184/901 (20%), Positives = 374/901 (41%), Gaps = 161/901 (17%)
Query: 214 RSSYLEYQKVMREIEHLSRLYIAYQFLLAED-----TKVRSAEELKEMQDKVIKLQEELS 268
R ++ + Q+ + ++ L R AY L TKV+ ++ ++++ EEL
Sbjct: 803 RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELL 862
Query: 269 ENDKKIKALNHEIEELEKR----------------------------------KDKETGG 294
+ +K + E+EE+E++ K +E
Sbjct: 863 KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEE 922
Query: 295 ILRSLEDALAEAQRVN-------TKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAA 347
IL LE + E + N K Q+ ++ L EE R++L+ V
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV-------T 975
Query: 348 KEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE--ATLAGQMMAC 405
E ++KK+ + + L++ ++K + + S+ L+ E+ A+ A + +
Sbjct: 976 AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM 1035
Query: 406 KNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRK--DQEALEAVKRLKEKLEA 463
+D+ + + ++ + +L+ A+++L + +++ + + D+ L+ K+ +E+L+
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK-EEELQG 1094
Query: 464 EMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
+ + + E + + L+ R+L I L+E +E+ A ++ + R+ +
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFES--------EKASRNKAEKQKRDLSE 1146
Query: 524 GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA 583
L A ++DT TTA + E+ K+ E ELK
Sbjct: 1147 ELEALKTELEDTLDTTAAQ-------------QELRTKREQEVAELK------------- 1180
Query: 584 RCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTT-----FVCDNMDNAKK 638
+ + ET + H A +L E +L++A F DN + A +
Sbjct: 1181 KALEEETKNHEAQIQDMRQRH-ATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 639 VAFDKRIMT----RTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
V +++ + L V + H +S G R + + K +L++ D + E
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLR-VELAEKASKLQNELDNVSTLLEE 1298
Query: 695 LRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQ-QEELDALKKTIE 753
A ++ + K+ A QL+ E+ EE + KL SS +Q +EE ++L++ E
Sbjct: 1299 --AEKKGIKFAKDAASLESQLQDTQELLQEET---RQKLNLSSRIRQLEEEKNSLQEQQE 1353
Query: 754 ESEETLKNTKE-----IQRKAEEKYEVLEN--KMKNAEAERERELKDAQKKLDCAKTKAD 806
E EE KN ++ + A+ K +V ++ +++ E +++ LKDA+ + KA
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413
Query: 807 ASSKKMKEK---QQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK 863
A K K K QQE++ +T++L+ +R+ S ++ + + + + E I AE
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDH-QRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Query: 864 NKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD------HNI 917
E+ +A+E+ TK + A + ++AK ++K+ D + + D H +
Sbjct: 1473 RAEA--EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 918 SKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKE 977
K KR E ++ L++ + LQ ++ K
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELE---------------------------DELQATEDAKL 1563
Query: 978 KLGRNVNMRAMNVLTEAEERYNDLM--KKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ 1035
+L VNM+AM E + + D +KKR++ ++ +E D++K +AL +A +
Sbjct: 1564 RL--EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE--DERKQRALAVASK 1619
Query: 1036 K 1036
K
Sbjct: 1620 K 1620
Score = 92.0 bits (227), Expect = 3e-18
Identities = 174/803 (21%), Positives = 327/803 (40%), Gaps = 107/803 (13%)
Query: 183 KTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREI-EHLSRLYIAYQFLL 241
+T+ K A LK ++ L+ +I + + E++S + +K R++ E L L + L
Sbjct: 1102 ETLHKNNA-LKVVRE-LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159
Query: 242 AEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLED 301
DT E + + +V +L++ L E K NHE + + R+ T L L +
Sbjct: 1160 --DTTAAQQELRTKREQEVAELKKALEEETK-----NHEAQIQDMRQRHATA--LEELSE 1210
Query: 302 ALAEAQRVNT---KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK-KITD 357
L +A+R K++ + K LACE ++++ K L A+ +E+ K+++
Sbjct: 1211 QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSE 1270
Query: 358 GLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGA------EATLAGQMMACKNDISK 411
G E AE + Q + VS L E A+L Q+ + + +
Sbjct: 1271 GDRLRVEL----AEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE 1326
Query: 412 AQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYE 471
+ +++ ++E KN E ++ + RK+ E + V L+ +L KK++ +
Sbjct: 1327 ETRQKLNLSSRIRQLEEE-KNSLQEQQEEEEEARKNLE--KQVLALQSQLADTKKKVDDD 1383
Query: 472 ENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS 531
ESL E +++L +D EAL R AY EK NR
Sbjct: 1384 LGTIESLEEAKKKLLKDA-------EALSQRLEEKALAYDKLEKTKNR------------ 1424
Query: 532 VKDTSATTALELVAGERLYNVVVDTEVTGKKL--LERGELKRRYTIIPLNKISARCIAPE 589
+ L ++ VD + + LE+ + K + ISAR
Sbjct: 1425 -------------LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEER 1471
Query: 590 TLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRT 649
A+ + ALSL E +A E N + A + +M+
Sbjct: 1472 DRAEAE---AREKETKALSLARALEEALEAKEEF--------ERQNKQLRADMEDLMSSK 1520
Query: 650 VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTA 709
+G +V + L R+ + +L++++DEL+ E+ LE + +K A
Sbjct: 1521 DDVGKNVHE----LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK--A 1574
Query: 710 EKYRQLKQQWEMKTEEADLLQTKLQQ-----SSYHKQQEELDALKKTIEESEETLKNTKE 764
+ R L+ + E E+ LL ++++ KQ+ A KK +E + L+ E
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634
Query: 765 IQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITL 824
KA ++ K++ + +REL++A+ D ++ S KK+K + E+ +
Sbjct: 1635 AANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Query: 825 ELEELKREHTSYKQQLEAVNEAIKSYES-----------------QIEVMAAEVAKNKES 867
EL +R +Q+ + + + I + S Q+E E N E
Sbjct: 1695 ELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL 1754
Query: 868 VNKAQEEVTKQKEVITAQDTVIK--AKYAEVAKHK--EQNNDSQLKIKELDHNI-SKHKR 922
+N + T Q + + A+ + A+ ++ A+ + QN + + K++EL+ + SK K
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1814
Query: 923 EAEDGAAKVSKMLKDYDWINAER 945
AK+ ++ + + ER
Sbjct: 1815 TISALEAKIGQLEEQLEQEAKER 1837
Score = 31.6 bits (70), Expect = 4.7
Identities = 26/111 (23%), Positives = 49/111 (44%), Gaps = 19/111 (17%)
Query: 177 KKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIA 236
++ AA K + + E KLKEI +E+E Q ++ + +++ R++E
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE------- 1888
Query: 237 YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR 287
AE+ R+ + KLQ EL + + + L+ E+ L+ R
Sbjct: 1889 -----AEEEATRANASRR-------KLQRELDDATEANEGLSREVSTLKNR 1927
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 105 bits (262), Expect = 3e-22
Identities = 202/935 (21%), Positives = 401/935 (42%), Gaps = 121/935 (12%)
Query: 171 TRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL-----EYQKVMR 225
T+ + K ++ +E + A LK+ IL + ++ T +L+ ++S+ L +Y +++
Sbjct: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460
Query: 226 EI-EHLSRLYIA-YQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEE 283
E+ E +L Q AE + +L+E + + ++Q + + + +A +++
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
Query: 284 LEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
K+ E + L D L Q++ + + ++K + EES + +++ +++E ++
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ-DILEQNE 579
Query: 344 TLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMM 403
L A+ ++ Q A+ A LA + + V A E +LA +
Sbjct: 580 ALKAQIQQFHS--------QIAAQTSASVLA---EELHKVIAEKDKQIKQTEDSLASE-- 626
Query: 404 ACKNDISKAQTEAKQAQ---MKLKHAQQELK---NKQA----EVKKMD-SGYRKDQEALE 452
++ ++ + E K Q LK Q+L+ N+QA E++KM S Y KD +
Sbjct: 627 --RDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK--- 681
Query: 453 AVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKD 512
++ L+E+L+ E+ EE K L ++ + L ++ +L + L++ PN KD
Sbjct: 682 -IRLLEEQLQHEISN-KMEEFK--ILNDQNKALKSEVQKL----QTLVSEQPN-----KD 728
Query: 513 PEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVV------VDTEVTGKKLLER 566
+ + C++ L +V++ T +++ E N + + EV K +
Sbjct: 729 VVEQMEK-CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQN 787
Query: 567 GELKRRYTIIPLNKI----SARCIAPETLRVAQNL-VGPDNVHVALSLVEYKPELQKAME 621
++ + L K+ + + E L A+ L V V LS+ ELQ ++
Sbjct: 788 DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLK 847
Query: 622 FVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTLGGDVFDPHGTLSGGARSQA------ASI 674
G + M+ K V +K + + T D+ + + +L + A AS
Sbjct: 848 ---GKE---EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 901
Query: 675 LTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE-----MKTEEADLL 729
++F+EL+ V L+ KENEL+ LE L ++ QL Q + K++ L
Sbjct: 902 ASQFEELEIV---LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK 958
Query: 730 QTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERER 789
Q QQ+S EEL K I E E+ + + + + + +E++ K RE+
Sbjct: 959 QQNYQQASSFPPHEEL---LKVISEREKEISG---LWNELDSLKDAVEHQRKKNNDLREK 1012
Query: 790 ELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE---------HTSYKQQL 840
+ + K D +K KE+QQ+VEA+ LE +E+ ++ + SY + L
Sbjct: 1013 NWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWL 1072
Query: 841 EAVNEAIK------SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVI----K 890
+ K S +++V+ ++ + E Q E K K V+ + ++ +
Sbjct: 1073 HGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR 1132
Query: 891 AKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAER-HLFG 949
+ E K K + ++S IK++ + + ++E E ++ KD + + ER HL
Sbjct: 1133 SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE----RLRSENKDIENLRREREHLEM 1188
Query: 950 QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVE 1009
+ A ++ E + +L E KL N E ++ DL K ++ +E
Sbjct: 1189 ELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQN--------ERQKVAGDLHKAQQSLE 1240
Query: 1010 NDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSI 1044
+SKI+ D +N ++ + K+ S+
Sbjct: 1241 LIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1275
Score = 72.8 bits (177), Expect = 2e-12
Identities = 169/917 (18%), Positives = 357/917 (38%), Gaps = 125/917 (13%)
Query: 179 IAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQ 238
+ ++ +++ K K+ K +LEE++ +KE +S + +KV E +++
Sbjct: 105 VETSSSVRERKKKEKKQKPVLEEQV------IKESDASKIPGKKV--EPVPVTKQPTPPS 156
Query: 239 FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKAL--NHEIEELEKRKDKETGGIL 296
A K ++ K D K E L K+ +AL + E ++ K+
Sbjct: 157 EAAASKKKP-GQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKK 215
Query: 297 RSLEDALAEAQRV----------NTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLA 346
+ E+ + + N S D ++ + + + ++K+ + KT
Sbjct: 216 QKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTET 275
Query: 347 AKEKEVKKITDGLHALQEASNKDAEALAAA---QQHFNAVSAGLSSNEDGAEATLAGQMM 403
KE K D L +L+ + EAL ++ + L + G TL Q+
Sbjct: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
Query: 404 ACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEA 463
++ + +A + + K QE+ ++ + + + R+K+++
Sbjct: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-------------ERSNVVITRMKDRIGT 382
Query: 464 EMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
K+ N +NK ++ +Q+ +++E EA +A +D N
Sbjct: 383 LEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLES 442
Query: 524 GLVASLISVKDTSATTALEL------VAGERLYNVVVDTEVTGKKLLERGELKRRYTIIP 577
A L ++ A EL + E + + T K ++ E +RR+ +
Sbjct: 443 KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLK-VQLQEAERRWEEVQ 501
Query: 578 LNKISARCIAPETLR--VAQNLVGPDN----VHVAL--SLVEYKPELQKAMEFVFGTTFV 629
+ I R E + + V +N +H L +LV + Q+ M+ +
Sbjct: 502 -SYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKR 560
Query: 630 CDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAAS------ILTKFQELKD 683
+ ++ + D I+ + L + H ++ + + I K +++K
Sbjct: 561 VNKEESLQMQVQD--ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618
Query: 684 VQDELRIKENELRALEEELAGLKN---------------------TAEKYRQLKQQWEMK 722
+D L + + L + EEEL ++N A + +++Q +K
Sbjct: 619 TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678
Query: 723 TEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQR----KAEEKYEVLEN 778
++ LL+ +LQ +K +E K + + + LK+ E+Q+ +E+ + +
Sbjct: 679 DDKIRLLEEQLQHEISNKMEE-----FKILNDQNKALKS--EVQKLQTLVSEQPNKDVVE 731
Query: 779 KMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELK---REHTS 835
+M+ E++ +LK ++ L+ + +++ + E ++T E+++LK + S
Sbjct: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
Query: 836 YKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAE 895
+ +E + + I +E ++ + E E + A +E T Q + +
Sbjct: 792 FASLVEELKKVI--HEKDGKIKSVEELLEAELLKVANKEKTVQLSITS------------ 837
Query: 896 VAKHKEQNNDSQLKIKELDHNISKH-KREAEDGAAKVSKMLKDYDWINAERHLFGQPNSA 954
K Q + LK KE N K E E A K L+D N Q +
Sbjct: 838 ----KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ 893
Query: 955 YDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVEN--DK 1012
++ K + + L+ + +KEK + AM +ER +DL K +++++ D+
Sbjct: 894 HNLKEASSASQFEELEIV--LKEKENELKRLEAM-----LKERESDLSSKTQLLQDVQDE 946
Query: 1013 SKIL-TTIEDLDQKKNQ 1028
+K+ + IE L Q+ Q
Sbjct: 947 NKLFKSQIEQLKQQNYQ 963
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 105 bits (262), Expect = 3e-22
Identities = 189/862 (21%), Positives = 350/862 (40%), Gaps = 126/862 (14%)
Query: 154 LNMKPPEILSMIEEAAGTRMYEYKKIA-AQKTIEKKEAKLKEIKTILEEEITPTIQKLKE 212
L K E+ + IEE E A A+K +L+EI LEE T +++
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 213 ERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSE 269
+ E+QK+ R++E + + A L + D+ E++ +Q KL++E SE
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 270 NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAF-DLKKKNLACEE 328
+I L +E + K K + R+LED L+E + + Q DL
Sbjct: 1230 MKMEIDDLASNVETVSKAKGN-LEKMCRTLEDQLSELKSKEEEQQRLINDLT-------- 1280
Query: 329 SKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS 388
++R L+ E S+ L KE V +++ G A + + L
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL--------------- 1325
Query: 389 SNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD- 447
E A+ LA + + ++D + + ++ Q Q+ L EV + + Y D
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 448 ----QEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARF 503
+E EA K+L ++L+A + + K SL + +++L ++ L E A
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445
Query: 504 PNLRFAYKDPEK---NWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
L ++ +K W + C + A L + + + + EL + Y +D T
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEE-THAELEASQKEARSLGTELFKIKNAYEESLDQLET- 1503
Query: 561 KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVH----VALSLVEYKPEL 616
LKR NK + I+ T ++A+ G +H + + + K EL
Sbjct: 1504 --------LKRE------NKNLQQEISDLTEQIAE---GGKRIHELEKIKKQVEQEKCEL 1546
Query: 617 QKAMEFVF-------GTTFVCDNMDNAKKVAFDKRIMTRTVTLGG-------DVFDPHGT 662
Q A+E G N K D++I + + V T
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 663 LSGGARSQAASILTKFQELKDVQDELRIKENEL-RALEEELAGLKNTA------------ 709
L RS+ +I K ++++ +E+ I+ N R E L +NT
Sbjct: 1607 LDAEIRSRNDAIRLK-KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 710 --EKYRQLKQQWEMKTEEADLLQTKLQQ----------SSYHKQQEELDALKKT--IEES 755
LK+Q M A+LLQ ++++ S +QE LDA ++ +
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725
Query: 756 EETLKNTK-----EIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASS- 809
+L NTK +I + E ++L+ + +NAE + ++ + DA + K + D S+
Sbjct: 1726 NTSLINTKKKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 810 --KKMKEKQQEVEAITLELEELKR-EHTSYKQQLEAVNEAIKSYESQIEVMA---AEVAK 863
+ K +Q V+ + L L+E ++ K+Q++ + ++ E ++E AE K
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844
Query: 864 NKESVNKAQEEVTKQ-----KEVITAQDTV------IKAKYAEVAKHKEQNNDSQLKIKE 912
+ +E+T Q K ++ QD V +K+ + + +EQ+N + K ++
Sbjct: 1845 GLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRK 1904
Query: 913 LDHNISKHKREAEDGAAKVSKM 934
L H + + + A+ ++V+K+
Sbjct: 1905 LQHELEEAEERADIAESQVNKL 1926
Score = 100 bits (248), Expect = 1e-20
Identities = 178/950 (18%), Positives = 385/950 (40%), Gaps = 115/950 (12%)
Query: 149 RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKI---AAQKTIEKKEAKLKEIKTI-- 198
++ K + ++ ++ EE AG ++ + KK A Q+T++ +A+ ++ T+
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 199 ----LEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEEL 253
LE+++ L++E+ ++ ++ R++E L +A + ++ E+ K + E+L
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE--GDLKLAQESIMDIENEKQQLDEKL 1086
Query: 254 KEMQDKVIKLQEELSEND-------KKIKALNHEIEELEK----------RKDKETGGIL 296
K+ + ++ LQ ++ + KKIK L IEELE+ + +K+ +
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKE----V 352
R LE+ + + + ++ KK A + R++LE+ ++ T A K+ V
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 353 KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS------NEDGAEATLAGQMMACK 406
++ + + LQ K + + + + +++ + + N + TL Q+ K
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 407 NDISKAQT-----EAKQAQMKLKHAQ--QELKNKQAEVKKMDSGYRKDQEALEAVKRLKE 459
+ + Q A++ +++ + + ++L K+A V ++ G Q + ++ LK
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRG---KQAFTQQIEELKR 1323
Query: 460 KLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKN--- 516
+LE E+K N +L + D L+E YE L+ A
Sbjct: 1324 QLEEEIKAKN-------ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 517 WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTII 576
W + +++ A L A E V + +K +R + + ++
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436
Query: 577 PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
+ + +A C A L Q E EL+ + + + NA
Sbjct: 1437 DVERTNAACAA---LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493
Query: 637 KKVAFDK--RIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
+ + D+ + L ++ D ++ G + + EL+ ++ ++ ++ E
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCE 1545
Query: 695 LRA-LEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIE 753
L+A LEE A L++ K +++ + E D ++ EE+D LK+
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVD--------RKIAEKDEEIDQLKRNHI 1597
Query: 754 ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMK 813
E++++T + + ++ L+ KM E +L + + +L+ A A + + +
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKM-------EGDLNEMEIQLNHANRMAAEALRNYR 1650
Query: 814 EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQE 873
Q ++ + L++ R K+QL V +++IE + A + + + S A++
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 874 EVTKQKEVI----TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
E+ E + T ++I K + + + ++E + K K+ D A
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 930 KVSKMLKDYDW-INAERHLFGQPNSAYDFKTNNP-------KEAGQRLQKLQEMKEKLGR 981
++ K+ D + ER + D + K +++QKL+ +L
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEG 1830
Query: 982 NV------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
V N A+ L + E R +L + E D+ IL ++DL K
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQ---TEEDRKNIL-RLQDLVDK 1876
Score = 97.4 bits (241), Expect = 7e-20
Identities = 163/837 (19%), Positives = 341/837 (40%), Gaps = 95/837 (11%)
Query: 238 QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDK--ETGGI 295
+F +D +S + KE+++K++ L +E ++ +++A + + E+R D+ +T
Sbjct: 861 EFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQ 920
Query: 296 LRSLEDALAEAQRVNTKSQSAFDLKKKNL--ACEESKR--KELEKNMVEDSKTLAAKEKE 351
L + + E + + KK+ L C E K+ +LE + + K A E +
Sbjct: 921 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980
Query: 352 VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
VK +T+ + L E K + A Q+ L + ED N ++K
Sbjct: 981 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV------------NTLTK 1028
Query: 412 AQTEAKQAQMKLKHAQQELKNKQAEV----KKMDSGYRKDQEALEAVKRLKEKLEAEMKK 467
A+ + +Q L+ + ++ K + ++ +K++ + QE++ ++ K++L+ ++KK
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Query: 468 LNYEENKEESLLEKRR----QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
+E + +S +E + QL + I L+ E L R + EK + +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ-RSDLSR 1147
Query: 524 GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRRYTIIPLNK 580
L +++ T+ ++ ++ E +K+ LE L+ T L K
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKK-------REAEFQKMRRDLEEATLQHEATAATLRK 1200
Query: 581 ISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVA 640
A +A ++ DN L V+ K E +K+ E + N++ K
Sbjct: 1201 KHADSVAELGEQI-------DN----LQRVKQKLEKEKS-EMKMEIDDLASNVETVSKAK 1248
Query: 641 FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAA---SILTKFQELKDVQDELRIKENELRA 697
+ M RT+ D L Q + + L+ E + +E A
Sbjct: 1249 GNLEKMCRTLE------DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 698 LEEELA-GLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
L +L+ G + ++ +LK+Q E + + + L LQ S + + D L++ EE +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS-----RHDCDLLREQYEEEQ 1357
Query: 757 ETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKL-----------DCAKTKA 805
E+ + KA + K + +R EL++A+KKL + K
Sbjct: 1358 ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417
Query: 806 DASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEV-AKN 864
+ K + Q EVE + L++E + ++ ++ + ++ + E AE+ A
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 865 KES---------VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH 915
KE+ + A EE Q E + ++ K E++ EQ + +I H
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKREN---KNLQQEISDLTEQIAEGGKRI----H 1530
Query: 916 NISKHKREAEDGAAKVSKMLKDYD--WINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ 973
+ K K++ E ++ L++ + + E + K+ ++ ++ +++
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 974 EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
++K R V + E R ND ++ K+ +E D +++ + ++ +AL
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSR-NDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Score = 94.0 bits (232), Expect = 8e-19
Identities = 210/1011 (20%), Positives = 419/1011 (41%), Gaps = 202/1011 (19%)
Query: 146 MQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEE---- 201
++ ++ +L K L + EA G E + KT + EAK+KE+ E+
Sbjct: 879 LEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 938
Query: 202 --EITPTIQKLKEERSSY--------LEYQKVMRE-------IEHLSRLYIAYQFLLAED 244
E+T +KL++E S L KV +E +++L+ +A+
Sbjct: 939 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL 998
Query: 245 TKVRSA---------EELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
TK + A ++L+ +DKV L + + ++++ L +E+ EK+ +
Sbjct: 999 TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ-EKKLRMDLERA 1057
Query: 296 LRSLEDALAEAQRVNTKSQSAFDLK-KKNLACEESKRKELE----KNMVEDSKTLAAK-E 349
R LE L AQ +S D++ +K E+ K+KE E ++ +ED + L + +
Sbjct: 1058 KRKLEGDLKLAQ------ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111
Query: 350 KEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS----NEDGAEATLA------ 399
K++K++ + L+E + + A A++ + +S L E+ AT A
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK 1171
Query: 400 ---GQMMACKNDISKA--QTEAKQAQMKLKHA----------------QQELKNKQAEVK 438
+ + D+ +A Q EA A ++ KHA +Q+L+ +++E+K
Sbjct: 1172 KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1231
Query: 439 KMDSGYRKDQEALEAVKRLKEK----LEAEMKKLNYEENKEESLLE----KRRQLSRDIG 490
+ E + K EK LE ++ +L +E +++ L+ +R +L + G
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291
Query: 491 ---RLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
R + EAL+++ + A+ + R ++ A AL
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL----------EEEIKAKNALAHALQS 1341
Query: 548 RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
++ + E ++ + EL+R L+K + T + + + A
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQR-----ALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 608 SLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGA 667
+ + LQ A E V C +++ K +R+ L DV + +
Sbjct: 1397 KKLAQR--LQAAEEHVEAVNAKCASLEKTK-----QRLQNEVEDLMLDVERTNAACAALD 1449
Query: 668 RSQA--ASILTKF-QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTE 724
+ Q IL ++ Q+ ++ EL + E R+L EL +KN E+ L Q +K E
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE--SLDQLETLKRE 1507
Query: 725 EADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAE 784
+L Q+E+ L + I E + + ++I+++ E++ L+ ++ AE
Sbjct: 1508 NKNL-------------QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Query: 785 AERERE---LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLE 841
A E E + Q +L+ K++ D +K+ EK +E+ ++LKR H + ++
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVD---RKIAEKDEEI-------DQLKRNHIRIVESMQ 1604
Query: 842 AV--------NEAIKSYE------SQIEV-------MAAEVAKNKESVN----------- 869
+ N+AI+ + +++E+ MAAE +N +
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664
Query: 870 ---KAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAED 926
++QE++ +Q ++ + +++A+ E+ EQ S+ KI E +E D
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR-KIAE---------QELLD 1714
Query: 927 GAAKVSKM-LKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNM 985
+ +V + ++ IN ++ L +T+ + G+ LQE RN
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKL----------ETDISQMQGEMEDILQE-----ARNAEE 1759
Query: 986 RAMNVLTEAEERYNDLMKKKRI---VENDKSKILTTIEDLDQKKNQALNIA 1033
+A +T+A +L K++ +E K + T++DL + ++A +A
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Score = 77.0 bits (188), Expect = 1e-13
Identities = 152/764 (19%), Positives = 304/764 (39%), Gaps = 102/764 (13%)
Query: 304 AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ 363
AE ++ + F K LA E+KRKELE+ MV K + +V+ +GL +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 364 EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEAT-----LAGQMMACKNDISKAQTEAK 417
E ++ + + V+ E+ AE T L + K DI +
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 418 QAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEES 477
+ + + + ++KN E+ +D K + K L+E + + L EE+K +
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAK---LTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 478 LLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
L + + +L + + L+ + E +L A + E + +K S++ +++
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-----LKLAQESIMDIENEKQ 1080
Query: 538 TTALELVAGE----RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRV 593
+L E L + + D + G +L ++ + ++ AR E
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKK-----------IKELQARIEELEEEIE 1129
Query: 594 AQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTL 652
A+ L E+ + +E G T M+ ++ F K R TL
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 653 GGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENEL----------------- 695
+ TL A + + L+ V+ +L +++E+
Sbjct: 1190 QHEA--TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA 1247
Query: 696 --------RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDA 747
R LE++L+ LK+ E+ ++L T + LQT + + +Q +E +A
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQRLIND---LTAQRGRLQT--ESGEFSRQLDEKEA 1302
Query: 748 LKKTIEESEETL-KNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKAD 806
L + ++ + +E++R+ EE E K KNA A L+ ++ D + + +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEE-----EIKAKNALA---HALQSSRHDCDLLREQYE 1354
Query: 807 ASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNK 865
+ E Q+ + E+ + + ++ T Q+ E + EA K +++ AAE
Sbjct: 1355 EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ--AAEEHVEA 1412
Query: 866 ESVNKAQEEVTKQKEVITAQDTVI---KAKYAEVAKHKEQNNDSQLKIKELDHNISKHKR 922
+ A E TKQ+ +D ++ + A A K+Q N D +++ K+
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN--------FDKILAEWKQ 1464
Query: 923 EAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRN 982
+ E+ A++ K+ + E FK N E + L +L+ +K + +N
Sbjct: 1465 KCEETHAELEASQKEARSLGTEL-----------FKIKNAYE--ESLDQLETLKRE-NKN 1510
Query: 983 VNMRAMNV---LTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
+ ++ + E +R ++L K K+ VE +K ++ +E+ +
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Score = 68.2 bits (165), Expect = 5e-11
Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 88/430 (20%)
Query: 683 DVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHK 740
D++ R E +L+ +E + ++N + QL ++ + K E LQ+K++ Q+ +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQ---QLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109
Query: 741 QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDC 800
Q+++ L+ IEE EE ++ + + KAE++ ++ REL++ ++L+
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQ-----------RSDLSRELEEISERLEE 1158
Query: 801 AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK------------------QQLEA 842
A A + K+++ E + + +LEE +H + L+
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 843 VNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAK---------- 892
V + ++ +S++++ ++A N E+V+KA+ + K + Q + +K+K
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278
Query: 893 --------YAEVAKHKEQNNDSQLKIKELD-------HNISKHKREAEDG-------AAK 930
E + Q ++ + + +L I + KR+ E+ A
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338
Query: 931 VSKMLKDYDWI------------NAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEK 978
+ D D + +R L ++T +A QR ++L+E K+K
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398
Query: 979 LGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIED--LDQKKNQALNIAWQK 1036
L + L AEE + K +E K ++ +ED LD ++ A A K
Sbjct: 1399 LAQR--------LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1450
Query: 1037 VNKDFGSIFS 1046
++F I +
Sbjct: 1451 KQRNFDKILA 1460
Score = 52.0 bits (123), Expect = 3e-06
Identities = 89/408 (21%), Positives = 175/408 (42%), Gaps = 75/408 (18%)
Query: 149 RITKVLNMKPPEILSMIEEAAGTRMYEYKKIAA-------------QKTIEKKEA--KLK 193
+I K + + E+ + +EEA + +E KI +K EK E +LK
Sbjct: 1534 KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593
Query: 194 EIKTILEEEITPTIQKLKEERSSYLEYQKVMR--------EIEHLSRL-------YIAYQ 238
+ E + T+ R+ + +K M ++ H +R+ Y Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653
Query: 239 FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE---KRKDKETGGI 295
+L +DT++ + L+ +D L+E+L+ +++ L EIEEL ++ ++
Sbjct: 1654 GIL-KDTQIHLDDALRSQED----LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 296 LRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKI 355
+ L DA Q ++T++ S + KKK L + S+ + ++++++++ A+EK K I
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKK-LETDISQMQGEMEDILQEARN--AEEKAKKAI 1765
Query: 356 TDGLHALQEASNK-DAEA-LAAAQQHFNAVSAGLSSNEDGAEA-TLAG---QMMACKNDI 409
TD +E + D A L +++ L D AE L G Q+ + +
Sbjct: 1766 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1825
Query: 410 SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMK--K 467
+ + E + Q + A + L+ + VK++ +D++ + ++ L +KL+A++K K
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885
Query: 468 LNYEENKE--------------------------ESLLEKRRQLSRDI 489
EE +E ES + K R SR++
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 105 bits (262), Expect = 3e-22
Identities = 189/862 (21%), Positives = 350/862 (40%), Gaps = 126/862 (14%)
Query: 154 LNMKPPEILSMIEEAAGTRMYEYKKIA-AQKTIEKKEAKLKEIKTILEEEITPTIQKLKE 212
L K E+ + IEE E A A+K +L+EI LEE T +++
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM 1169
Query: 213 ERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSE 269
+ E+QK+ R++E + + A L + D+ E++ +Q KL++E SE
Sbjct: 1170 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1229
Query: 270 NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAF-DLKKKNLACEE 328
+I L +E + K K + R+LED L+E + + Q DL
Sbjct: 1230 MKMEIDDLASNVETVSKAKGN-LEKMCRTLEDQLSELKSKEEEQQRLINDLT-------- 1280
Query: 329 SKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS 388
++R L+ E S+ L KE V +++ G A + + L
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL--------------- 1325
Query: 389 SNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD- 447
E A+ LA + + ++D + + ++ Q Q+ L EV + + Y D
Sbjct: 1326 EEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDA 1385
Query: 448 ----QEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARF 503
+E EA K+L ++L+A + + K SL + +++L ++ L E A
Sbjct: 1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAAC 1445
Query: 504 PNLRFAYKDPEK---NWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
L ++ +K W + C + A L + + + + EL + Y +D T
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEE-THAELEASQKEARSLGTELFKIKNAYEESLDQLET- 1503
Query: 561 KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVH----VALSLVEYKPEL 616
LKR NK + I+ T ++A+ G +H + + + K EL
Sbjct: 1504 --------LKRE------NKNLQQEISDLTEQIAE---GGKRIHELEKIKKQVEQEKCEL 1546
Query: 617 QKAMEFVF-------GTTFVCDNMDNAKKVAFDKRIMTRTVTLGG-------DVFDPHGT 662
Q A+E G N K D++I + + V T
Sbjct: 1547 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 663 LSGGARSQAASILTKFQELKDVQDELRIKENEL-RALEEELAGLKNTA------------ 709
L RS+ +I K ++++ +E+ I+ N R E L +NT
Sbjct: 1607 LDAEIRSRNDAIRLK-KKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 710 --EKYRQLKQQWEMKTEEADLLQTKLQQ----------SSYHKQQEELDALKKT--IEES 755
LK+Q M A+LLQ ++++ S +QE LDA ++ +
Sbjct: 1666 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725
Query: 756 EETLKNTK-----EIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASS- 809
+L NTK +I + E ++L+ + +NAE + ++ + DA + K + D S+
Sbjct: 1726 NTSLINTKKKLETDISQMQGEMEDILQ-EARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 810 --KKMKEKQQEVEAITLELEELKR-EHTSYKQQLEAVNEAIKSYESQIEVMA---AEVAK 863
+ K +Q V+ + L L+E ++ K+Q++ + ++ E ++E AE K
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVK 1844
Query: 864 NKESVNKAQEEVTKQ-----KEVITAQDTV------IKAKYAEVAKHKEQNNDSQLKIKE 912
+ +E+T Q K ++ QD V +K+ + + +EQ+N + K ++
Sbjct: 1845 GLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRK 1904
Query: 913 LDHNISKHKREAEDGAAKVSKM 934
L H + + + A+ ++V+K+
Sbjct: 1905 LQHELEEAEERADIAESQVNKL 1926
Score = 100 bits (248), Expect = 1e-20
Identities = 178/950 (18%), Positives = 385/950 (40%), Gaps = 115/950 (12%)
Query: 149 RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKI---AAQKTIEKKEAKLKEIKTI-- 198
++ K + ++ ++ EE AG ++ + KK A Q+T++ +A+ ++ T+
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 199 ----LEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEEL 253
LE+++ L++E+ ++ ++ R++E L +A + ++ E+ K + E+L
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE--GDLKLAQESIMDIENEKQQLDEKL 1086
Query: 254 KEMQDKVIKLQEELSEND-------KKIKALNHEIEELEK----------RKDKETGGIL 296
K+ + ++ LQ ++ + KKIK L IEELE+ + +K+ +
Sbjct: 1087 KKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKE----V 352
R LE+ + + + ++ KK A + R++LE+ ++ T A K+ V
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 353 KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS------NEDGAEATLAGQMMACK 406
++ + + LQ K + + + + +++ + + N + TL Q+ K
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 407 NDISKAQT-----EAKQAQMKLKHAQ--QELKNKQAEVKKMDSGYRKDQEALEAVKRLKE 459
+ + Q A++ +++ + + ++L K+A V ++ G Q + ++ LK
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRG---KQAFTQQIEELKR 1323
Query: 460 KLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKN--- 516
+LE E+K N +L + D L+E YE L+ A
Sbjct: 1324 QLEEEIKAKN-------ALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ 1376
Query: 517 WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTII 576
W + +++ A L A E V + +K +R + + ++
Sbjct: 1377 WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1436
Query: 577 PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
+ + +A C A L Q E EL+ + + + NA
Sbjct: 1437 DVERTNAACAA---LDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNA 1493
Query: 637 KKVAFDK--RIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
+ + D+ + L ++ D ++ G + + EL+ ++ ++ ++ E
Sbjct: 1494 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGK--------RIHELEKIKKQVEQEKCE 1545
Query: 695 LRA-LEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIE 753
L+A LEE A L++ K +++ + E D ++ EE+D LK+
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVD--------RKIAEKDEEIDQLKRNHI 1597
Query: 754 ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMK 813
E++++T + + ++ L+ KM E +L + + +L+ A A + + +
Sbjct: 1598 RIVESMQSTLDAEIRSRNDAIRLKKKM-------EGDLNEMEIQLNHANRMAAEALRNYR 1650
Query: 814 EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQE 873
Q ++ + L++ R K+QL V +++IE + A + + + S A++
Sbjct: 1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1710
Query: 874 EVTKQKEVI----TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
E+ E + T ++I K + + + ++E + K K+ D A
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 930 KVSKMLKDYDW-INAERHLFGQPNSAYDFKTNNP-------KEAGQRLQKLQEMKEKLGR 981
++ K+ D + ER + D + K +++QKL+ +L
Sbjct: 1771 MAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEG 1830
Query: 982 NV------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
V N A+ L + E R +L + E D+ IL ++DL K
Sbjct: 1831 EVESEQKRNAEAVKGLRKHERRVKELTYQ---TEEDRKNIL-RLQDLVDK 1876
Score = 97.4 bits (241), Expect = 7e-20
Identities = 163/837 (19%), Positives = 341/837 (40%), Gaps = 95/837 (11%)
Query: 238 QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDK--ETGGI 295
+F +D +S + KE+++K++ L +E ++ +++A + + E+R D+ +T
Sbjct: 861 EFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQ 920
Query: 296 LRSLEDALAEAQRVNTKSQSAFDLKKKNL--ACEESKR--KELEKNMVEDSKTLAAKEKE 351
L + + E + + KK+ L C E K+ +LE + + K A E +
Sbjct: 921 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 980
Query: 352 VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
VK +T+ + L E K + A Q+ L + ED N ++K
Sbjct: 981 VKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV------------NTLTK 1028
Query: 412 AQTEAKQAQMKLKHAQQELKNKQAEV----KKMDSGYRKDQEALEAVKRLKEKLEAEMKK 467
A+ + +Q L+ + ++ K + ++ +K++ + QE++ ++ K++L+ ++KK
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Query: 468 LNYEENKEESLLEKRR----QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
+E + +S +E + QL + I L+ E L R + EK + +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ-RSDLSR 1147
Query: 524 GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRRYTIIPLNK 580
L +++ T+ ++ ++ E +K+ LE L+ T L K
Sbjct: 1148 ELEEISERLEEAGGATSAQIEMNKK-------REAEFQKMRRDLEEATLQHEATAATLRK 1200
Query: 581 ISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVA 640
A +A ++ DN L V+ K E +K+ E + N++ K
Sbjct: 1201 KHADSVAELGEQI-------DN----LQRVKQKLEKEKS-EMKMEIDDLASNVETVSKAK 1248
Query: 641 FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAA---SILTKFQELKDVQDELRIKENELRA 697
+ M RT+ D L Q + + L+ E + +E A
Sbjct: 1249 GNLEKMCRTLE------DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 698 LEEELA-GLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESE 756
L +L+ G + ++ +LK+Q E + + + L LQ S + + D L++ EE +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSS-----RHDCDLLREQYEEEQ 1357
Query: 757 ETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKL-----------DCAKTKA 805
E+ + KA + K + +R EL++A+KKL + K
Sbjct: 1358 ESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKC 1417
Query: 806 DASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEV-AKN 864
+ K + Q EVE + L++E + ++ ++ + ++ + E AE+ A
Sbjct: 1418 ASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 865 KES---------VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH 915
KE+ + A EE Q E + ++ K E++ EQ + +I H
Sbjct: 1478 KEARSLGTELFKIKNAYEESLDQLETLKREN---KNLQQEISDLTEQIAEGGKRI----H 1530
Query: 916 NISKHKREAEDGAAKVSKMLKDYD--WINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ 973
+ K K++ E ++ L++ + + E + K+ ++ ++ +++
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 974 EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
++K R V + E R ND ++ K+ +E D +++ + ++ +AL
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSR-NDAIRLKKKMEGDLNEMEIQLNHANRMAAEAL 1646
Score = 94.0 bits (232), Expect = 8e-19
Identities = 210/1011 (20%), Positives = 419/1011 (41%), Gaps = 202/1011 (19%)
Query: 146 MQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEE---- 201
++ ++ +L K L + EA G E + KT + EAK+KE+ E+
Sbjct: 879 LEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 938
Query: 202 --EITPTIQKLKEERSSY--------LEYQKVMRE-------IEHLSRLYIAYQFLLAED 244
E+T +KL++E S L KV +E +++L+ +A+
Sbjct: 939 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL 998
Query: 245 TKVRSA---------EELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
TK + A ++L+ +DKV L + + ++++ L +E+ EK+ +
Sbjct: 999 TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ-EKKLRMDLERA 1057
Query: 296 LRSLEDALAEAQRVNTKSQSAFDLK-KKNLACEESKRKELE----KNMVEDSKTLAAK-E 349
R LE L AQ +S D++ +K E+ K+KE E ++ +ED + L + +
Sbjct: 1058 KRKLEGDLKLAQ------ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ 1111
Query: 350 KEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS----NEDGAEATLA------ 399
K++K++ + L+E + + A A++ + +S L E+ AT A
Sbjct: 1112 KKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK 1171
Query: 400 ---GQMMACKNDISKA--QTEAKQAQMKLKHA----------------QQELKNKQAEVK 438
+ + D+ +A Q EA A ++ KHA +Q+L+ +++E+K
Sbjct: 1172 KREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK 1231
Query: 439 KMDSGYRKDQEALEAVKRLKEK----LEAEMKKLNYEENKEESLLE----KRRQLSRDIG 490
+ E + K EK LE ++ +L +E +++ L+ +R +L + G
Sbjct: 1232 MEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESG 1291
Query: 491 ---RLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
R + EAL+++ + A+ + R ++ A AL
Sbjct: 1292 EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQL----------EEEIKAKNALAHALQS 1341
Query: 548 RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
++ + E ++ + EL+R L+K + T + + + A
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQR-----ALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 608 SLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGA 667
+ + LQ A E V C +++ K +R+ L DV + +
Sbjct: 1397 KKLAQR--LQAAEEHVEAVNAKCASLEKTK-----QRLQNEVEDLMLDVERTNAACAALD 1449
Query: 668 RSQA--ASILTKF-QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTE 724
+ Q IL ++ Q+ ++ EL + E R+L EL +KN E+ L Q +K E
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE--SLDQLETLKRE 1507
Query: 725 EADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAE 784
+L Q+E+ L + I E + + ++I+++ E++ L+ ++ AE
Sbjct: 1508 NKNL-------------QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Query: 785 AERERE---LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLE 841
A E E + Q +L+ K++ D +K+ EK +E+ ++LKR H + ++
Sbjct: 1555 ASLEHEEGKILRIQLELNQVKSEVD---RKIAEKDEEI-------DQLKRNHIRIVESMQ 1604
Query: 842 AV--------NEAIKSYE------SQIEV-------MAAEVAKNKESVN----------- 869
+ N+AI+ + +++E+ MAAE +N +
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664
Query: 870 ---KAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAED 926
++QE++ +Q ++ + +++A+ E+ EQ S+ KI E +E D
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR-KIAE---------QELLD 1714
Query: 927 GAAKVSKM-LKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNM 985
+ +V + ++ IN ++ L +T+ + G+ LQE RN
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKL----------ETDISQMQGEMEDILQE-----ARNAEE 1759
Query: 986 RAMNVLTEAEERYNDLMKKKRI---VENDKSKILTTIEDLDQKKNQALNIA 1033
+A +T+A +L K++ +E K + T++DL + ++A +A
Sbjct: 1760 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLA 1810
Score = 77.0 bits (188), Expect = 1e-13
Identities = 152/764 (19%), Positives = 304/764 (39%), Gaps = 102/764 (13%)
Query: 304 AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ 363
AE ++ + F K LA E+KRKELE+ MV K + +V+ +GL +
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 364 EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEAT-----LAGQMMACKNDISKAQTEAK 417
E ++ + + V+ E+ AE T L + K DI +
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 418 QAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEES 477
+ + + + ++KN E+ +D K + K L+E + + L EE+K +
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAK---LTKEKKALQEAHQQTLDDLQAEEDKVNT 1025
Query: 478 LLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSA 537
L + + +L + + L+ + E +L A + E + +K S++ +++
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-----LKLAQESIMDIENEKQ 1080
Query: 538 TTALELVAGE----RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRV 593
+L E L + + D + G +L ++ + ++ AR E
Sbjct: 1081 QLDEKLKKKEFEISNLQSKIEDEQALGIQLQKK-----------IKELQARIEELEEEIE 1129
Query: 594 AQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK-RIMTRTVTL 652
A+ L E+ + +E G T M+ ++ F K R TL
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 653 GGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENEL----------------- 695
+ TL A + + L+ V+ +L +++E+
Sbjct: 1190 QHEA--TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKA 1247
Query: 696 --------RALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDA 747
R LE++L+ LK+ E+ ++L T + LQT + + +Q +E +A
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQRLIND---LTAQRGRLQT--ESGEFSRQLDEKEA 1302
Query: 748 LKKTIEESEETL-KNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKAD 806
L + ++ + +E++R+ EE E K KNA A L+ ++ D + + +
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEE-----EIKAKNALA---HALQSSRHDCDLLREQYE 1354
Query: 807 ASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNK 865
+ E Q+ + E+ + + ++ T Q+ E + EA K +++ AAE
Sbjct: 1355 EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ--AAEEHVEA 1412
Query: 866 ESVNKAQEEVTKQKEVITAQDTVI---KAKYAEVAKHKEQNNDSQLKIKELDHNISKHKR 922
+ A E TKQ+ +D ++ + A A K+Q N D +++ K+
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN--------FDKILAEWKQ 1464
Query: 923 EAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRN 982
+ E+ A++ K+ + E FK N E + L +L+ +K + +N
Sbjct: 1465 KCEETHAELEASQKEARSLGTEL-----------FKIKNAYE--ESLDQLETLKRE-NKN 1510
Query: 983 VNMRAMNV---LTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
+ ++ + E +R ++L K K+ VE +K ++ +E+ +
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAE 1554
Score = 68.2 bits (165), Expect = 5e-11
Identities = 86/430 (20%), Positives = 178/430 (41%), Gaps = 88/430 (20%)
Query: 683 DVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHK 740
D++ R E +L+ +E + ++N + QL ++ + K E LQ+K++ Q+ +
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQ---QLDEKLKKKEFEISNLQSKIEDEQALGIQ 1109
Query: 741 QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDC 800
Q+++ L+ IEE EE ++ + + KAE++ ++ REL++ ++L+
Sbjct: 1110 LQKKIKELQARIEELEEEIEAERASRAKAEKQ-----------RSDLSRELEEISERLEE 1158
Query: 801 AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK------------------QQLEA 842
A A + K+++ E + + +LEE +H + L+
Sbjct: 1159 AGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 843 VNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAK---------- 892
V + ++ +S++++ ++A N E+V+KA+ + K + Q + +K+K
Sbjct: 1219 VKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278
Query: 893 --------YAEVAKHKEQNNDSQLKIKELD-------HNISKHKREAEDG-------AAK 930
E + Q ++ + + +L I + KR+ E+ A
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338
Query: 931 VSKMLKDYDWI------------NAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEK 978
+ D D + +R L ++T +A QR ++L+E K+K
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKK 1398
Query: 979 LGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIED--LDQKKNQALNIAWQK 1036
L + L AEE + K +E K ++ +ED LD ++ A A K
Sbjct: 1399 LAQR--------LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1450
Query: 1037 VNKDFGSIFS 1046
++F I +
Sbjct: 1451 KQRNFDKILA 1460
Score = 52.0 bits (123), Expect = 3e-06
Identities = 89/408 (21%), Positives = 175/408 (42%), Gaps = 75/408 (18%)
Query: 149 RITKVLNMKPPEILSMIEEAAGTRMYEYKKIAA-------------QKTIEKKEA--KLK 193
+I K + + E+ + +EEA + +E KI +K EK E +LK
Sbjct: 1534 KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1593
Query: 194 EIKTILEEEITPTIQKLKEERSSYLEYQKVMR--------EIEHLSRL-------YIAYQ 238
+ E + T+ R+ + +K M ++ H +R+ Y Q
Sbjct: 1594 RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1653
Query: 239 FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE---KRKDKETGGI 295
+L +DT++ + L+ +D L+E+L+ +++ L EIEEL ++ ++
Sbjct: 1654 GIL-KDTQIHLDDALRSQED----LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 296 LRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKI 355
+ L DA Q ++T++ S + KKK L + S+ + ++++++++ A+EK K I
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKK-LETDISQMQGEMEDILQEARN--AEEKAKKAI 1765
Query: 356 TDGLHALQEASNK-DAEA-LAAAQQHFNAVSAGLSSNEDGAEA-TLAG---QMMACKNDI 409
TD +E + D A L +++ L D AE L G Q+ + +
Sbjct: 1766 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1825
Query: 410 SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMK--K 467
+ + E + Q + A + L+ + VK++ +D++ + ++ L +KL+A++K K
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885
Query: 468 LNYEENKE--------------------------ESLLEKRRQLSRDI 489
EE +E ES + K R SR++
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 104 bits (260), Expect = 4e-22
Identities = 166/867 (19%), Positives = 360/867 (41%), Gaps = 115/867 (13%)
Query: 238 QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILR 297
+F +D +S + KE+++K++ L +E ++ +++A + + + E+R D+ +++
Sbjct: 856 EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQ----LIK 911
Query: 298 SLEDALAEAQRVNTKSQSAFDL------KKKNL--ACEESKR--KELEKNMVEDSKTLAA 347
+ A+ + V +++ ++ KK+ L C E K+ +LE + + K A
Sbjct: 912 AKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 971
Query: 348 KEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKN 407
E +VK +T+ L L E K A Q+ L + ED N
Sbjct: 972 TENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKV------------N 1019
Query: 408 DISKAQTEAKQAQMKLKHAQQELKNKQAEV----KKMDSGYRKDQEALEAVKRLKEKLEA 463
++K +++ +Q L+ + ++ K + ++ +K++ + QE++ ++ K++L+
Sbjct: 1020 SLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079
Query: 464 EMKKLNYEENKEESLLEKRR----QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR 519
+KK ++E + +S +E + Q + I L+ E L R EK
Sbjct: 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ-RS 1138
Query: 520 NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLN 579
+ + L +++ T+ ++ ++ + ++ LE L+ + L
Sbjct: 1139 DYARELEELSERLEEAGGVTSTQIELNKKREAEFLKL----RRDLEEATLQHEAMVAALR 1194
Query: 580 KISARCIAP-----ETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMD 634
K A +A + L+ + + + L + + ++ + +C ++
Sbjct: 1195 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE 1254
Query: 635 NAKKVAFDK----------------RIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKF 678
+ A K R+ T L + + +S +RS+ A
Sbjct: 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT---- 1310
Query: 679 QELKDVQDELRIKENELRALEEELAGLKNTAEKYR-QLKQQWEMKTEEADLLQTKLQQSS 737
Q+ ++++ +L + AL L ++ + R Q +++ E K E L + +
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370
Query: 738 YHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERER---ELKDA 794
+ + E DA+++T EE EE K + + +EE+ E + K + E ++R E++D
Sbjct: 1371 QWRTKYETDAIQRT-EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL 1429
Query: 795 QKKLDCAKTKADASSKKMK--------------EKQQEVEA-------ITLELEELKREH 833
++ A + A A KK + E Q E+EA ++ EL +LK +
Sbjct: 1430 MVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 1489
Query: 834 TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKY 893
QLE V K+ E +I + ++A+N +++++ E+ KQ E+ A D + +
Sbjct: 1490 EEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL-EKSRKQIELEKA-DIQLALEE 1547
Query: 894 AEVAKHKEQ-------------NNDSQLKIKELDHNISKHKREAEDGAAKVSKML----- 935
AE A E+ ++ KI E D I + KR + + L
Sbjct: 1548 AEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR 1607
Query: 936 KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAE 995
+ I ++ + G N ++ ++A + L+ L+ ++ +L ++ + L +A
Sbjct: 1608 SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL-KDTQLH----LDDAL 1662
Query: 996 ERYNDLMKKKRIVENDKSKILTTIEDL 1022
DL ++ IVE + + +E+L
Sbjct: 1663 RGQEDLKEQLAIVERRANLLQAEVEEL 1689
Score = 98.6 bits (244), Expect = 3e-20
Identities = 189/886 (21%), Positives = 353/886 (39%), Gaps = 143/886 (16%)
Query: 131 FCSVGLNVNNPHFLIMQ-GRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE 189
+C + V + L +Q + K L + E+ IE TR K Q++ +E
Sbjct: 1088 YCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRA----KTEKQRSDYARE 1143
Query: 190 AKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTK 246
L+E+ LEE T +++ + E+ K+ R++E + + A L + D+
Sbjct: 1144 --LEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSV 1201
Query: 247 VRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEA 306
E++ +Q KL++E SE +I L+ +E + K K I R+LED L+EA
Sbjct: 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSK-ANLEKICRTLEDQLSEA 1260
Query: 307 QRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEAS 366
+ N + Q ++L+ +++ L+ E S+ L KE V +++ A + +
Sbjct: 1261 RGKNEEIQ-------RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQT 1313
Query: 367 NKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHA 426
+ L E+ A+ LA + + ++D + + ++ Q
Sbjct: 1314 EELKRQL---------------EEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1358
Query: 427 QQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLS 486
Q+ L +EV + + Y D A++ + L+E + ++L E + E++ K L
Sbjct: 1359 QRALSKANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLE 1416
Query: 487 RDIGRLKETYEALLA---RFPNLRFAYKDPEKN-------WNRNCVKGLVASLISVKDTS 536
+ RL+ E L+ R +L A ++N W C + S+K+ S
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE-S 1475
Query: 537 ATTALELVAGERLYNVVVDTEVTGKK---------------LLERG----ELKRRYTIIP 577
+ + EL + Y +D T K+ + E G EL++ I
Sbjct: 1476 RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE 1535
Query: 578 LNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAM----EFVFGTTFVCDNM 633
L K + +A E A + + L L + K E+ + + E +
Sbjct: 1536 LEKADIQ-LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRT 1594
Query: 634 DNAKKVAFDKRIMTRTVTLG------GDVFDPHGTLSGGARSQAASILTKFQ----ELKD 683
+ A D + +R + GD+ + LS R QAA L + +LKD
Sbjct: 1595 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR-QAAETLKHLRSVQGQLKD 1653
Query: 684 VQ----DELRIKE-------------NELRALEEELAGLKNTAEKYRQLKQQWEMKTEE- 725
Q D LR +E N L+A EEL E+ R+L +Q + + E
Sbjct: 1654 TQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNER 1713
Query: 726 ADLLQTKLQQSSYHKQQEELDA--LKKTIEESEETLKNTKEIQRKAEEKYEVLENKMK-- 781
LL T+ + K++ E D L+ +E++ +N +E +KA ++ ++K
Sbjct: 1714 VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1773
Query: 782 ---NAEAER-----ERELKDAQKKLDCAKTKADASSKKMKEK------------------ 815
+A ER E+ +KD Q +LD A+ A KK +K
Sbjct: 1774 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKK 1833
Query: 816 -----------QQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
++ V+ +T + EE ++ + ++ + +KSY+ Q E + +
Sbjct: 1834 NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAH 1893
Query: 865 KESVNKAQ---EEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQ 907
KAQ EE ++ ++ +Q ++AK + + ++S+
Sbjct: 1894 LTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESE 1939
Score = 94.7 bits (234), Expect = 5e-19
Identities = 182/877 (20%), Positives = 360/877 (41%), Gaps = 143/877 (16%)
Query: 175 EYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY 234
E K + ++KK+ + ++++ +E+E T +Q K+ + +++ EIE
Sbjct: 1071 ENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE------ 1124
Query: 235 IAYQFLLAEDTKVRS--AEELKEMQDK------VIKLQEELS-ENDKKIKALNHEIEELE 285
A + A+ K RS A EL+E+ ++ V Q EL+ + + + L ++EE
Sbjct: 1125 -AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEAT 1183
Query: 286 KRKDKETGGILRSLEDALAE-------AQRVN---TKSQSAFDLKKKNLACEESKRKELE 335
+ + + + D++AE QRV K +S F L+ +L+ + +
Sbjct: 1184 LQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSK 1243
Query: 336 KNMVEDSKTL-------AAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS 388
N+ + +TL K +E+++ L + +A L+ + ++ + LS
Sbjct: 1244 ANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303
Query: 389 -----------------SNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELK 431
E+ A+ LA + + ++D + + ++ Q Q+ L
Sbjct: 1304 RSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363
Query: 432 NKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGR 491
+EV + + Y D A++ + L+E + ++L E + E++ K L + R
Sbjct: 1364 KANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQR 1421
Query: 492 LKETYEALLA---RFPNLRFAYKDPEKN-------WNRNCVKGLVASLISVKDTSATTAL 541
L+ E L+ R +L A ++N W C + S+K+ S + +
Sbjct: 1422 LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE-SRSLST 1480
Query: 542 ELVAGERLYNVVVDTEVTGKK---------------LLERG----ELKRRYTIIPLNKIS 582
EL + Y +D T K+ + E G EL++ I L K
Sbjct: 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKAD 1540
Query: 583 ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAM----EFVFGTTFVCDNMDNAKK 638
+ +A E A + + L L + K E+ + + E + +
Sbjct: 1541 IQ-LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Query: 639 VAFDKRIMTRTVT------LGGDVFDPHGTLSGGARSQAASILTKFQ----ELKDVQ--- 685
A D + +R + GD+ + LS A QAA L + +LKD Q
Sbjct: 1600 SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLS-HANRQAAETLKHLRSVQGQLKDTQLHL 1658
Query: 686 -DELRIKE-------------NELRALEEELAGLKNTAEKYRQLKQQWEM-KTEEADLLQ 730
D LR +E N L+A EEL E+ R+L +Q + E LL
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718
Query: 731 TKLQQSSYHKQQEELD--ALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMK-----NA 783
T+ + K++ E D L+ +E++ +N +E +KA ++ ++K +A
Sbjct: 1719 TQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSA 1778
Query: 784 EAER-----ERELKDAQKKLDCAKTKADASSKKMKEK-QQEVEAITLELEELKREHTSYK 837
ER E+ +KD Q +LD A+ A KK +K + + + ELE ++++T
Sbjct: 1779 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT--- 1835
Query: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVA 897
E+V + ++ YE +++ + + +++++V + Q+ V K + +K+ +
Sbjct: 1836 ---ESV-KGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQ-------VKVKSYKRQAE 1884
Query: 898 KHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM 934
+ EQ N K ++ H + + + A+ ++V+K+
Sbjct: 1885 EADEQANAHLTKFRKAQHELEEAEERADIAESQVNKL 1921
Score = 94.4 bits (233), Expect = 6e-19
Identities = 190/931 (20%), Positives = 370/931 (39%), Gaps = 165/931 (17%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AED 244
E K L + K+ LE+++ L++E+ ++ ++ R++E L +A + +L E+
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLE--GDLKLAQESILDLEN 1072
Query: 245 TKVRSAEELKEMQDKVIKLQEELSEND-------KKIKALNHEIEELEK----------R 287
K + E LK+ + +LQ ++ + KKIK L IEELE+ +
Sbjct: 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 1132
Query: 288 KDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAA 347
+K+ R LE+ + + + +L KK A R++LE+ ++ +AA
Sbjct: 1133 TEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAA 1192
Query: 348 KEKE----VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMM 403
K+ V ++ + + LQ K L + F LSS+ + + A
Sbjct: 1193 LRKKHADSVAELGEQIDNLQRVKQK----LEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248
Query: 404 ACK---NDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEK 460
C+ + +S+A+ + ++ Q L + Q E ++ + + + + R K+
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA 1308
Query: 461 LEA---EMKKLNYEENKEESLLEKRRQLSR-DIGRLKETYEALLARFPNLRFAYKDPEKN 516
E+K+ EENK ++ L Q SR D L+E YE L+ A
Sbjct: 1309 FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1368
Query: 517 WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTII 576
VA + +T A E + E KKL +R +
Sbjct: 1369 ---------VAQWRTKYETDAIQRTE------------ELEEAKKKLAQRLQDSEEQ--- 1404
Query: 577 PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
+ ++A+C + E + Q L G V + VE L A++
Sbjct: 1405 -VEAVNAKCASLE--KTKQRLQG--EVEDLMVDVERANSLAAALD--------------K 1445
Query: 637 KKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELR 696
K+ FDK + + +L +RS + + ++ D+L + E +
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKE-SRSLSTELFKLKNAYEEALDQLETVKRENK 1504
Query: 697 ALEEELAGLKN-------TAEKYRQLKQQWEMKT----------------EEADLLQTKL 733
LE+E+A L T + + ++Q E++ EEA +L+ +L
Sbjct: 1505 NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL 1564
Query: 734 QQSSYHKQ--------QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKN--- 782
+ + + EE++ LK+ + + ET+++ + + ++ + L+ KM+
Sbjct: 1565 ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 1624
Query: 783 ------AEAERER------------ELKDAQKKLDCA-------KTKADASSKKMKEKQQ 817
+ A R+ +LKD Q LD A K + ++ Q
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Query: 818 EVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTK 877
EVE + LE+ +R +Q+L NE ++ +Q + K + + + Q EV
Sbjct: 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV-- 1742
Query: 878 QKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKD 937
+D A+ AE K K+ D+ + +EL ++ +D +A + +M K+
Sbjct: 1743 -------EDASRDARNAE-EKAKKAITDAAMMAEEL--------KKEQDTSAHLERMKKN 1786
Query: 938 YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQ-KLQEMKEKL--GRNVNMRAMNVLTEA 994
+ + L + + A K+ Q+L+ +++E++ +L + N ++ L +
Sbjct: 1787 LE--QTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKY 1844
Query: 995 EERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
E R +L + E D+ +L ++DL K
Sbjct: 1845 ERRVKELTYQS---EEDRKNVL-RLQDLVDK 1871
Score = 73.6 bits (179), Expect = 1e-12
Identities = 154/707 (21%), Positives = 289/707 (40%), Gaps = 96/707 (13%)
Query: 163 SMIEEAAG--TRMYEYKKIAAQKTIEKKEA---KLKEIKTILEEE------ITPTIQKLK 211
S ++ AG +R E K+ + K+A + +E+K LEEE + +Q +
Sbjct: 1279 SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338
Query: 212 EE----RSSYLEYQKVMREIEHL---SRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQ 264
+ R Y E Q+ E++ + +A E ++ EEL+E + K L
Sbjct: 1339 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK---LA 1395
Query: 265 EELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL 324
+ L +++++++A+N + LEK K + G +ED + + +R N+ + +A D K++N
Sbjct: 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQG----EVEDLMVDVERANSLA-AALDKKQRNF 1450
Query: 325 ACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS 384
+ E + E L A KE + ++ L L+ A + + L ++ +
Sbjct: 1451 ---DKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLE 1507
Query: 385 AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQA--QMKLKHAQQELKNKQAEVKKMDS 442
++ D E + + S+ Q E ++A Q+ L+ A+ L++++A++ ++
Sbjct: 1508 QEIA---DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ- 1563
Query: 443 GYRKDQEALEAVKRLKEK-LEAEMKKLNYEENKE--ESLLEKRRQLSRDIGRLKETYEAL 499
Q E +++ EK E E K NY+ E +S L+ + + RLK+ E
Sbjct: 1564 -LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGD 1622
Query: 500 LARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVT 559
L ++ ++ NR + L L SV+ T L L D +
Sbjct: 1623 LNEI-EIQLSHA------NRQAAETL-KHLRSVQGQLKDTQLHL-----------DDALR 1663
Query: 560 GKKLLER--GELKRRYTIIPLNKISARCIAPETLR---VAQNLVGPDNVHVAL------S 608
G++ L+ ++RR ++ R +T R +A+ + N V L S
Sbjct: 1664 GQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723
Query: 609 LVEYKPEL-----QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTL 663
L+ K +L Q E + + + AKK D +M + D +
Sbjct: 1724 LIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1783
Query: 664 SGGARSQAASILTKFQE-----LKDVQDELRIKENELRALEEELAG--LKNT-----AEK 711
+ + E LK + +++ E +R LE EL G KNT K
Sbjct: 1784 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRK 1843
Query: 712 YRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEE 771
Y + ++ ++EE D Q K Q ++ + K+ EE++E RKA+
Sbjct: 1844 YERRVKELTYQSEE-DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQH 1902
Query: 772 KYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQE 818
+ E EAE ++ ++Q AKT+ SS+ + + +E
Sbjct: 1903 ELE---------EAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Score = 70.9 bits (172), Expect = 7e-12
Identities = 139/735 (18%), Positives = 292/735 (39%), Gaps = 68/735 (9%)
Query: 388 SSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD 447
S+ + AT+ + K++++K++ + K+ + KL QE + Q +V+
Sbjct: 843 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 448 QEALEAVKRLKEKLEAEMKKLNYEENKEES----LLEKRRQLSRDIGRLKETYEALLARF 503
+E + + + K +LEA++K++ EE L K+R+L + LK+ + L
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL---- 958
Query: 504 PNLRFAYKDPEKNWNRNCVKGLVASLISVKD-----TSATTALELVAGERLYNVVVDTEV 558
L A + EK+ N VK L L + + T AL+ + L ++ + +
Sbjct: 959 -ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK 1017
Query: 559 TGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNV--HVALSLVEYKPEL 616
+ +L+++ + + + + + R + L G + L L K +L
Sbjct: 1018 VNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQL 1077
Query: 617 Q---KAMEFVFGTTFVCDNMDNAKKVAFDKRI---MTRTVTLGGDVFDPHGTLSGGARSQ 670
K +F + + + F K+I R L ++ T + Q
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK-TEKQ 1136
Query: 671 AASILTKFQELKDVQDEL-----------RIKENELRALEEEL--AGLKNTAEKYRQLKQ 717
+ + +EL + +E + +E E L +L A L++ A K+
Sbjct: 1137 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKK 1196
Query: 718 QWEMKTE---EADLLQTKLQQSSYHKQQE--ELDALKKTIEESEETLKNTKEIQRKAEEK 772
+ E + D LQ Q+ K + E+D L ++E ++ N ++I R E+
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED- 1255
Query: 773 YEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE 832
++ E + KN E +R QK +T+A S++++EK+ V ++ + ++
Sbjct: 1256 -QLSEARGKNEEIQRSLSELTTQKSR--LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQ 1312
Query: 833 HTSYKQQLEAVNE-------AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVIT-- 883
K+QLE N+ A++S +++ + + +E + Q ++K +
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Query: 884 ----AQDTVIKAKYAEVAKHK--EQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKD 937
D + + + E AK K ++ DS+ +++ ++ + ++ + +V ++ D
Sbjct: 1373 RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVD 1432
Query: 938 YDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEER 997
+ N+ + +D K + Q E K R+++ + EE
Sbjct: 1433 VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA 1492
Query: 998 YNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLA 1057
+ L KR +N + +I E + + + +K K L A+ LA
Sbjct: 1493 LDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL--EKSRKQIE------LEKADIQLA 1544
Query: 1058 PPEGQTVLDGLEFKV 1072
E + L+ E K+
Sbjct: 1545 LEEAEAALEHEEAKI 1559
Score = 48.5 bits (114), Expect = 4e-05
Identities = 57/259 (22%), Positives = 114/259 (44%), Gaps = 33/259 (12%)
Query: 780 MKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELE------ELKREH 833
+K+AE E+E A K + KTK + + + K K+ E + +TL E +++ E
Sbjct: 841 LKSAETEKEM----ATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAES 896
Query: 834 TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKY 893
+ E ++ IK+ + Q+E EV + E + E+T +K + + + +K
Sbjct: 897 ENLLDAEERCDQLIKA-KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955
Query: 894 AE----VAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFG 949
+ +AK +++ + ++ K+K L +S ++ AK+++ K
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNLTEELS----GLDETIAKLTREKKAL----------- 1000
Query: 950 QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVE 1009
A+ ++ + ++ L + K KL + V ++ E + R DL + KR +E
Sbjct: 1001 --QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV-DLERNKRKLE 1057
Query: 1010 NDKSKILTTIEDLDQKKNQ 1028
D +I DL+ K Q
Sbjct: 1058 GDLKLAQESILDLENDKQQ 1076
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 104 bits (260), Expect = 4e-22
Identities = 182/875 (20%), Positives = 369/875 (42%), Gaps = 128/875 (14%)
Query: 183 KTIEKKEAKLKEIKTILEE--EITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL 240
K + K KE+ T+ EE I T++K E R LE +K++ ++ + L + Q
Sbjct: 839 KPLLKSAETEKEMATMKEEFGRIKETLEK-SEARRKELE-EKMVSLLQEKNDLQLQVQ-- 894
Query: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLE 300
AE + AEE D++IK + +L + K+K +N +E+ E+ + E R LE
Sbjct: 895 -AEQDNLNDAEE---RCDQLIKNKIQL---EAKVKEMNERLED-EEEMNAELTAKKRKLE 946
Query: 301 DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
D +E ++ D + LA E ++ E + ++ +A ++ + K+T
Sbjct: 947 DECSELKK-------DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKK 999
Query: 361 ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
ALQEA + + L + N++S E + D+ + + K+ +
Sbjct: 1000 ALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVD------------DLEGSLEQEKKVR 1047
Query: 421 MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLE 480
M L+ A+ +K++ + QE++ ++ K +LE ++KK ++ N++ S +E
Sbjct: 1048 MDLERAK----------RKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIE 1097
Query: 481 K--------RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISV 532
+++L + R++E E L A R A EK + S +S
Sbjct: 1098 DEQVLALQLQKKLKENQARIEELEEELEAE----RTARAKVEK----------LRSDLSR 1143
Query: 533 KDTSATTALELVAGERLYNVVVDT--EVTGKKL---LERGELKRRYTIIPLNKISARCIA 587
+ + LE G + ++ E +K+ LE L+ T L K A +A
Sbjct: 1144 ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVA 1203
Query: 588 PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMT 647
++ DN L V+ K E +K+ EF V NM+ K + ++
Sbjct: 1204 ELGEQI-------DN----LQRVKQKLEKEKS-EFKLELDDVTSNMEQIIKAKANLEKVS 1251
Query: 648 RTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELA-GLK 706
RT+ D + + A+ T+ +L+ EL + E AL +L G
Sbjct: 1252 RTLE---DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKL 1308
Query: 707 NTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQ 766
+ ++ LK+Q E + + + L LQ + + + D L++ EE E + +
Sbjct: 1309 SYTQQMEDLKRQLEEEGKAKNALAHALQSARH-----DCDLLREQYEEETEAKAELQRVL 1363
Query: 767 RKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLEL 826
KA + K + +R EL++A+KKL ++++++ ++ VEA+ +
Sbjct: 1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKL----------AQRLQDAEEAVEAVNAKC 1413
Query: 827 EELKREHTSYKQQLEAV-------NEAIKSYESQIEVMAAEVAKNKESVNKAQEEV-TKQ 878
L++ + ++E + N A + + + +A+ K+ ++Q E+ + Q
Sbjct: 1414 SSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1473
Query: 879 KEVITAQDTVIKAK--YAEVAKH----KEQNNDSQLKIKELD----------HNISKHKR 922
KE + + K K Y E +H K +N + Q +I +L H + K ++
Sbjct: 1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRK 1533
Query: 923 EAEDGAAKVSKMLKDYD--WINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLG 980
+ E ++ L++ + + E + K ++ ++ +++++ K
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQ 1593
Query: 981 RNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKI 1015
R V+ ++ E R N++++ K+ +E D +++
Sbjct: 1594 RVVDSLQTSLDAETRSR-NEVLRVKKKMEGDLNEM 1627
Score = 102 bits (254), Expect = 2e-21
Identities = 169/779 (21%), Positives = 337/779 (43%), Gaps = 125/779 (16%)
Query: 185 IEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQ----KVMREIEHLSRLYIAYQFL 240
I K +A L+++ LE++ KL+E + S ++ K+ E L+R + L
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL 1299
Query: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALN---HEIEELEKRKDKETGGILR 297
+++ T+ + + ++M+D +L+EE + AL H+ + L ++ ++ET
Sbjct: 1300 ISQLTRGKLSYT-QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEET----- 1353
Query: 298 SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKR-KELEKNMVEDSKTLAAKEKEVKKIT 356
+A AE QRV +K+ S + + +R +ELE+ + ++ L E+ V+ +
Sbjct: 1354 ---EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN 1410
Query: 357 DGLHALQEASNK---DAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQ 413
+L++ ++ + E L + NA +A L + + LA + +
Sbjct: 1411 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA-----------EWK 1459
Query: 414 TEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNY--- 470
+ +++Q +L+ +Q+E ++ E+ K+ + Y + E LE KR + L+ E+ L
Sbjct: 1460 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1519
Query: 471 EENKEESLLEK-RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASL 529
E K LEK R+QL + L+ E A + + +N+ +K +
Sbjct: 1520 EGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ--IKAEIERK 1577
Query: 530 ISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPE 589
++ KD E+ +R + VVD+ T R E
Sbjct: 1578 LAEKDE------EMEQAKRNHQRVVDSLQTSLDAETRSR-------------------NE 1612
Query: 590 TLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRT 649
LRV + + G N + E+Q + +A ++A + + ++
Sbjct: 1613 VLRVKKKMEGDLN----------EMEIQ---------------LSHANRMAAEAQKQVKS 1647
Query: 650 VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTA 709
+ +L + Q + +LK+ + + N L+A EEL +
Sbjct: 1648 LQ----------SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1697
Query: 710 EKYRQLKQQWEMKTEEADLLQTKLQQSSYH---KQQEELDALKKTIEESEETLKNTKEIQ 766
E+ R+L +Q ++T E L S + K + +L L+ +EE+ + +N +E
Sbjct: 1698 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKA 1757
Query: 767 RKAEEKYEVLENKMK-----NAEAER-----ERELKDAQKKLDCAKTKADASSKKMKEKQ 816
+KA ++ ++K +A ER E+ +KD Q +LD A+ A KK +K
Sbjct: 1758 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQK- 1816
Query: 817 QEVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEV 875
+EA ELE EL+ E K+ E+V KS E +I+ + + ++K+++ + Q+ V
Sbjct: 1817 --LEARVRELEGELEAEQ---KRNAESVKGMRKS-ERRIKELTYQTEEDKKNLLRLQDLV 1870
Query: 876 TKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM 934
K + +KA + + +EQ N + K +++ H + + + A+ ++V+K+
Sbjct: 1871 DKLQ-------LKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1922
Score = 98.6 bits (244), Expect = 3e-20
Identities = 189/953 (19%), Positives = 378/953 (39%), Gaps = 146/953 (15%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
E K L + K LE+++ L++E+ ++ ++ R++E +L + E+
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKL-TQESIMDLEND 1074
Query: 246 KVRSAEELKEMQDKV--------------IKLQEELSENDKKIKALNHEIEE---LEKRK 288
K++ E+LK+ + + ++LQ++L EN +I+ L E+E +
Sbjct: 1075 KLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKV 1134
Query: 289 DKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAK 348
+K + R LE+ + + ++ KK A + R++LE+ ++ T AA
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 349 EKE----VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLS------SNEDGAEATL 398
K+ V ++ + + LQ K + + + + V++ + +N + TL
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254
Query: 399 AGQMMACKNDISKAQ-------TEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEAL 451
Q + + +AQ T+ + Q + ++L+ K+A + ++ G + +
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQM 1314
Query: 452 EAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSR-DIGRLKETYEA---LLARFPNLR 507
E +KR E EE K ++ L Q +R D L+E YE A +
Sbjct: 1315 EDLKRQLE-----------EEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVL 1363
Query: 508 FAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERG 567
W + +++ A +RL + E K
Sbjct: 1364 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLA------QRLQDAEEAVEAVNAKCSSLE 1417
Query: 568 ELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKP-------ELQKAM 620
+ K R N+I + E A + + L E+K EL+ +
Sbjct: 1418 KTKHRLQ----NEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQ 1473
Query: 621 EFVFGTTFVCDNMDNAKKVAFD--KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKF 678
+ + + NA + + + + L ++ D L G ++
Sbjct: 1474 KEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKN--------V 1525
Query: 679 QELKDVQDELRIKENELR-ALEEELAGLKNTAEK-------YRQLKQQWEMKTEEADLLQ 730
EL+ V+ +L +++ EL+ ALEE A L++ K + Q+K + E K E D
Sbjct: 1526 HELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD--- 1582
Query: 731 TKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAE---AER 787
+ + + Q +D+L+ +++ + +++K E +E ++ +A AE
Sbjct: 1583 -EEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEA 1641
Query: 788 ERELKDAQKKLDCAKTKAD---ASSKKMKEK-----------QQEVEAITLELEELKREH 833
++++K Q L + + D ++ +KE Q E+E + +E+ +R
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701
Query: 834 TSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQ-KEVITAQDTVIK-- 890
+Q+L +E ++ SQ + + K + + + Q EV + +E A++ K
Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761
Query: 891 ---AKYAEVAKHKEQNNDSQLK---------IKELDHNISKHKREAEDGAAKVSKMLK-- 936
A AE K KEQ+ + L+ IK+L H + + ++ A G K + L+
Sbjct: 1762 TDAAMMAEELK-KEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEAR 1820
Query: 937 --------DYDWINAERHLFGQPNSAYDFK--TNNPKEAGQRLQKLQEMKEKLGRNVNMR 986
+ + + G S K T +E + L +LQ++ +KL V
Sbjct: 1821 VRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAY 1880
Query: 987 AMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNK 1039
EAEE+ N + K R V++ +LD+ + +A +IA +VNK
Sbjct: 1881 KRQA-EEAEEQANTNLSKFRKVQH----------ELDEAEERA-DIAESQVNK 1921
Score = 65.1 bits (157), Expect = 4e-10
Identities = 85/411 (20%), Positives = 177/411 (43%), Gaps = 77/411 (18%)
Query: 171 TRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHL 230
T +++ K A ++++E E +E K L+EEI+ ++L E + E +KV +++E
Sbjct: 1481 TELFKLKN-AYEESLEHLETFKRENKN-LQEEISDLTEQLGEGGKNVHELEKVRKQLE-- 1536
Query: 231 SRLYIAYQFLLAEDTKVRSAEE-----LKEMQDKVIKLQEELSENDKKI-KALNHEIEEL 284
E +++SA E L+ + K+++ Q E ++ +I + L + EE+
Sbjct: 1537 -----------VEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM 1585
Query: 285 EKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKT 344
E+ K + + D+L + T+S++ KK + E E+E + ++
Sbjct: 1586 EQAKRNH-----QRVVDSLQTSLDAETRSRNEVLRVKKKM---EGDLNEMEIQLSHANRM 1637
Query: 345 LAAKEKEVKKITDGLHALQ-------EASNKDAEALAAAQQHFNAVSAGLSSNEDGAEAT 397
A +K+VK + L Q A++ E +A ++ N + A L E T
Sbjct: 1638 AAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT 1697
Query: 398 ---------------------------LAGQMMACKNDISKAQTEAKQAQMKLKHAQQEL 430
L Q ++D+++ Q+E ++A + ++A+++
Sbjct: 1698 ERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKA 1757
Query: 431 KNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEK--RRQLSRD 488
K + M +K+Q+ ++R+K+ +E +K L + ++ E + K ++QL +
Sbjct: 1758 KKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKL 1817
Query: 489 IGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATT 539
R++E L + E+ N VKG+ S +K+ + T
Sbjct: 1818 EARVRELEGEL------------EAEQKRNAESVKGMRKSERRIKELTYQT 1856
Score = 55.5 bits (132), Expect = 3e-07
Identities = 92/446 (20%), Positives = 184/446 (41%), Gaps = 94/446 (21%)
Query: 127 VQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIA------ 180
+ DL +G N H L ++ K L ++ E+ S +EEA + +E KI
Sbjct: 1511 ISDLTEQLGEGGKNVHEL---EKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEF 1567
Query: 181 -----------AQKTIEKKEAK------LKEIKTILEEEITPTIQKLKEERSSYLEYQKV 223
A+K E ++AK + ++T L+ E + L+ ++ + ++
Sbjct: 1568 NQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEM 1627
Query: 224 MREIEHLSRLYI-------AYQFLLAE-----DTKVRSAEELKE-----------MQDKV 260
++ H +R+ + Q LL + D VR+ ++LKE +Q ++
Sbjct: 1628 EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAEL 1687
Query: 261 IKL--------------QEELSENDKKIKALNHEIEELEKRKDKETGGILR---SLEDAL 303
+L ++EL E ++++ L+ + L +K K + + +E+A+
Sbjct: 1688 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAV 1747
Query: 304 AEAQRVNTKSQSAFDLKKKNLACEESKRKE--------LEKNMVEDSKTLAAKEKEVKKI 355
E + K++ A + + EE K+++ ++KNM + K L + E ++I
Sbjct: 1748 QECRNAEEKAKKA--ITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805
Query: 356 T--DGLHALQ--EASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
G LQ EA ++ E A+Q NA S + L Q K ++ +
Sbjct: 1806 ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR 1865
Query: 412 AQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYE 471
Q + Q+K+K +++ + + + S +RK Q L+ + + E+++ KL
Sbjct: 1866 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL--- 1922
Query: 472 ENKEESLLEKRRQLSRDIGRLKETYE 497
R SRDIG ++ ++
Sbjct: 1923 -----------RAKSRDIGAKQKMHD 1937
Score = 49.3 bits (116), Expect = 2e-05
Identities = 66/293 (22%), Positives = 117/293 (39%), Gaps = 38/293 (12%)
Query: 149 RITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQ 208
R +L + E+ +++E+ +R K+A Q+ IE E +L + T I
Sbjct: 1678 RRNNLLQAELEELRAVVEQTERSR-----KLAEQELIETSERV-----QLLHSQNTSLIN 1727
Query: 209 KLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELS 268
+ K+ S + Q + E R D + AEELK+ QD L+
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMM-AEELKKEQDTSAHLERMKK 1786
Query: 269 ENDKKIKALNHEIEELE-------KRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKK 321
++ IK L H ++E E K++ ++ +R LE L Q+ N +S
Sbjct: 1787 NMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES-------V 1839
Query: 322 KNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFN 381
K + E + KEL ED K L + V K+ + A + + + E F
Sbjct: 1840 KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1899
Query: 382 AVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
V L E+ A DI+++Q +A+ + A+Q++ +++
Sbjct: 1900 KVQHELDEAEERA-------------DIAESQVNKLRAKSRDIGAKQKMHDEE 1939
Score = 33.1 bits (74), Expect = 1.6
Identities = 32/133 (24%), Positives = 61/133 (45%), Gaps = 16/133 (12%)
Query: 892 KYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQP 951
K AE K + +IKE ++E E+ K+ +L++ + + +
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKSEARRKELEE---KMVSLLQEKNDLQLQ------- 892
Query: 952 NSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYN-DLMKKKRIVEN 1010
+ +N +A +R +L +K K+ ++ MN E EE N +L KKR +E+
Sbjct: 893 ---VQAEQDNLNDAEERCDQL--IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED 947
Query: 1011 DKSKILTTIEDLD 1023
+ S++ I+DL+
Sbjct: 948 ECSELKKDIDDLE 960
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 103 bits (258), Expect = 7e-22
Identities = 185/879 (21%), Positives = 378/879 (43%), Gaps = 141/879 (16%)
Query: 239 FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDK--ETGGIL 296
F ++ RS KE+++K++ L +E ++ ++++ + + E+R + ++ +L
Sbjct: 860 FERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILL 919
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNL--ACEESKRK-----------ELEKNMVED-- 341
+ L E + S KK+NL C KR E EK+ E+
Sbjct: 920 EAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKV 979
Query: 342 ---SKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNA---VSAGLSSNEDGAE 395
S+ + A E+ + K+T +LQEA + + L + N ++A L D E
Sbjct: 980 KNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLE 1039
Query: 396 ATLAGQMMACKNDISKAQTE-------AKQAQMKLKHAQQE----LKNKQAEVKKMDSGY 444
+L Q + D+ +A+ + ++++ M L++ +Q+ LK K+ E+ ++ +
Sbjct: 1040 GSLE-QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKI 1098
Query: 445 RKDQ-EALEAVKRLKEKLEAEMKKLNYEENKEESL---LEKRR-QLSRDI----GRLKET 495
+Q +L+ K++KE L+A +++L E E +L +EK+R L+R++ RL+E
Sbjct: 1099 DDEQVHSLQFQKKIKE-LQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEA 1157
Query: 496 YEALLARFPNLRFAYKDPEKNWNRNCVKGLV---ASLISVKDTSATTALELVAGERLYNV 552
A A+ + + +K R+ + + A+ +++ A + EL GE++ N+
Sbjct: 1158 SGATSAQIEMNKKREAEFQK-MRRDLEEATLQHEATAATLRKKQADSVAEL--GEQIDNL 1214
Query: 553 VVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEY 612
V K E+ ELK + N + R + V S ++
Sbjct: 1215 ---QRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCR------TVEDQFSEIKA 1265
Query: 613 KPELQKAMEFVFGTTFVCD-NMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQA 671
K E Q T + D NM A R+ T+ L V + +S +S+
Sbjct: 1266 KDEQQ--------TQLIHDLNMQKA-------RLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 672 ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQT 731
A + + +ELK R E E +A L+++ L++Q+E + E LQ
Sbjct: 1311 A-LTQQLEELK------RQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 732 KLQQSSYH----KQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAER 787
L +++ + + E DA+++T EE EE K + ++AEE E +K + E +
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRT-EELEEAKKKLAQRLQEAEENTETANSKCASLEKTK 1422
Query: 788 ER---ELKDAQKKLD-----CA----------------KTKADASSKKMKEKQQEVEAIT 823
+R E++D + L+ CA K K D S +++ Q+E +++
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLS 1482
Query: 824 LELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVIT 883
EL +++ + QLE + K+ + +I + ++A+ +++ +A+ K K+++
Sbjct: 1483 TELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE----KTKKLVE 1538
Query: 884 AQDTVIKAKYAEV---AKHKEQ------------NNDSQLKIKELDHNISKHKREAEDGA 928
+ + ++ EV +H+E ++ K+ E D I + KR ++ A
Sbjct: 1539 QEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAA 1598
Query: 929 AKVSKML-----KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV 983
+ +L D + ++ + G N ++ ++ + + L+ ++ +L
Sbjct: 1599 EALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL---- 1654
Query: 984 NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDL 1022
+ L +A DL ++ IVE +L +E++
Sbjct: 1655 -KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEM 1692
Score = 95.5 bits (236), Expect = 3e-19
Identities = 195/982 (19%), Positives = 417/982 (42%), Gaps = 170/982 (17%)
Query: 152 KVLNMKPPEILSMIEEAAGTRMYEYKKI--AAQKTI------EKKEAKLKEIKTILEEEI 203
KV N+ E ++ +EE E K + A Q+T+ E K L +I LE++
Sbjct: 978 KVKNLS--EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT 1035
Query: 204 TPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEELKEMQDKVIK 262
L++E+ + ++ R++E L ++ + ++ E+ K + E+LK+ + ++ +
Sbjct: 1036 DDLEGSLEQEKKLRADLERAKRKLE--GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093
Query: 263 LQEELSEND-------KKIKALNHEIEELEK----------RKDKETGGILRSLEDALAE 305
LQ ++ + KKIK L IEELE+ + +K+ + R LE+
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER 1153
Query: 306 AQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEK-------EVKKITDG 358
+ + + + ++ KK A + R++LE+ ++ T A K E+ + D
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 359 LHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLA------GQMMACKNDISKA 412
L +++ K+ L + LS ++ E T ++ A ++
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 413 QTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEE 472
+ + +L+ EL ++ E + + S K ++A L ++LE E+K+ EE
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQA------LTQQLE-ELKRQMEEE 1326
Query: 473 NKEESLLEKRRQLSR-DIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS 531
K ++ + Q SR D L+E YE L+ A VA +
Sbjct: 1327 TKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSE---------VAQWRT 1377
Query: 532 VKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETL 591
+T A E + E KKL +R + T +++C + E
Sbjct: 1378 KYETDAIQRTE------------ELEEAKKKLAQRLQEAEENT----ETANSKCASLE-- 1419
Query: 592 RVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVT 651
+ Q L G E++ M + + C +D K+ FDK +
Sbjct: 1420 KTKQRLQG---------------EVEDLMRDLERSHTACATLDK-KQRNFDKVLAEWKQK 1463
Query: 652 LGGDVFDPHGTLSGGARSQAASILTKFQELK----DVQDELRIKENELRALEEELAGL-- 705
L D A+ ++ S+ T+ +++ +V D+L E + L+EE++ L
Sbjct: 1464 L-----DESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTE 1518
Query: 706 ------KN--TAEKYRQLKQQ-------------WEMKTEEADLLQTKLQQSSYHKQQEE 744
KN AEK ++L +Q ++ EE+ +L+ +L+ S + + E
Sbjct: 1519 QIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELS---QVKSE 1575
Query: 745 LDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKN------AEAERERELKDAQKKL 798
LD +K IE+ EE + + QR AE VL+ ++++ + + E +L + + +L
Sbjct: 1576 LD--RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQL 1633
Query: 799 DCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMA 858
+ + + K ++ Q +++ L L++ R + K+QL V ++E M
Sbjct: 1634 GHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMK 1693
Query: 859 AEVAKNKESVNKAQEEV---TKQKEVITAQDT-VIKAK----------YAEVAKHKEQNN 904
+ + + + +++E+ + + +++ +Q+T +I K AEV +++
Sbjct: 1694 VALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESR 1753
Query: 905 DSQLKIKELDHN---ISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNN 961
+++ K K+ + +++ ++ +D +A + +M K+ + + L + + A
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE--QTVKDLQHRLDEAEQLALKG 1811
Query: 962 PKEAGQRLQ-KLQEMKEKL------------GRNVNMRAMNVLT-EAEERYNDLMKKKRI 1007
K+ Q+L+ +++E++ +L G + R + +T +AEE + ++++ + +
Sbjct: 1812 GKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDL 1871
Query: 1008 VENDKSKILTTIEDLDQKKNQA 1029
V+ ++K+ + ++ + QA
Sbjct: 1872 VDKLQAKVKSYKRQAEEAEEQA 1893
Score = 84.0 bits (206), Expect = 8e-16
Identities = 152/768 (19%), Positives = 315/768 (41%), Gaps = 110/768 (14%)
Query: 304 AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGL---- 359
AEA++ + F+ K+ LA E++RKELE+ MV + + +V+ T+ L
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906
Query: 360 ---------HALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDIS 410
L EA K+ ++ N+ N + ++L + + ++
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966
Query: 411 KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA----LEAVKRLKEKLEAEMK 466
K + E + K+K+ +E+ + + K+ + QEA L+ ++ ++K+ +K
Sbjct: 967 KVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIK 1026
Query: 467 ---KLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
KL + + E LE+ ++L D+ R K E L + D E + K
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE---SIMDLEND------K 1077
Query: 524 GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA 583
+ + K+ + + E+++++ ++ EL+ R + ++
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK--------ELQAR-----IEELEE 1124
Query: 584 RCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK 643
A TLR D L E+ + +E G T M+ ++ F K
Sbjct: 1125 EIEAEHTLRAKIEKQRSD-------LARELEEISERLEEASGATSAQIEMNKKREAEFQK 1177
Query: 644 -RIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELR------ 696
R TL + TL A + + L+ V+ +L +++EL+
Sbjct: 1178 MRRDLEEATLQHEA--TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235
Query: 697 -----ALEEELAGLKNTA----EKYRQLKQQWEMKTE---EADLLQTKLQQSS---YHKQ 741
AL + + ++ T +++ ++K + E +T+ + ++ + +LQ + H+
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRV 1295
Query: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCA 801
+E+ + + + + + +E++R+ EE E K KNA A L+ ++ D
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEE-----ETKAKNAMA---HALQSSRHDCDLL 1347
Query: 802 KTKADASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIKSYESQIEVMAAE 860
+ + + + E Q+ + E+ + + ++ T Q+ E + EA K +++ E
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ----E 1403
Query: 861 VAKNKESVNK--AQEEVTKQK---EVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH 915
+N E+ N A E TKQ+ EV + ++ A K+Q N D
Sbjct: 1404 AEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN--------FDK 1455
Query: 916 NISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEM 975
+++ K++ ++ A++ K+ ++ E LF N AY+ + + + + LQE
Sbjct: 1456 VLAEWKQKLDESQAELEAAQKESRSLSTE--LFKMRN-AYEEVVDQLETLRRENKNLQEE 1512
Query: 976 KEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
L + N L EAE K K++VE +KS + +E+++
Sbjct: 1513 ISDLTEQIAETGKN-LQEAE-------KTKKLVEQEKSDLQVALEEVE 1552
Score = 82.8 bits (203), Expect = 2e-15
Identities = 177/832 (21%), Positives = 334/832 (40%), Gaps = 128/832 (15%)
Query: 177 KKIAAQKTIEKKEAK--------LKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIE 228
++I A+ T+ K K L+EI LEE T +++ + E+QK+ R++E
Sbjct: 1124 EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 229 HLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE 285
+ + A L + D+ E++ +Q KL++E SE +I + IE L
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 286 KRKDKETGGILRSLEDALAEAQ-RVNTKSQSAFDL-------------------KKKNLA 325
K K R++ED +E + + ++Q DL +K++L
Sbjct: 1244 KSKSN-IERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLI 1302
Query: 326 CEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSA 385
+ +K K+ +E+ K +E + K HALQ +S D + L + A
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAM--AHALQ-SSRHDCDLLREQYEEEQEAKA 1359
Query: 386 GLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNK------------ 433
L A + +A + D + E ++A+ KL QE +
Sbjct: 1360 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLE 1419
Query: 434 ------QAEVKKMDSGYRKDQEA---LEAVKRLKEKLEAEMK-KLNYEENKEESLLEKRR 483
Q EV+ + + A L+ +R +K+ AE K KL+ + + E+ ++ R
Sbjct: 1420 KTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR 1479
Query: 484 QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWN----------RNCVKG-LVASLISV 532
LS ++ +++ YE ++ + LR K+ ++ + +N + L+
Sbjct: 1480 SLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQ 1539
Query: 533 KDTSATTALELVAG----ERLYNVVVDTEVTG-KKLLERGELKRRYTIIPLNKISARCIA 587
+ + ALE V G E + V E++ K L+R +++ I L + S R
Sbjct: 1540 EKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAE 1599
Query: 588 P-------------ETLRVAQNLVGPDNV------HVALSLVEYKPELQKAMEFVFGTTF 628
+ LR+ + + G N H + E + L+ + +
Sbjct: 1600 ALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQL 1659
Query: 629 VCD-----NMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKD 683
D N D +++A +R R L ++ + L R++ S QEL D
Sbjct: 1660 HLDDALRSNEDLKEQLAIVER---RNGLLLEELEEMKVALEQTERTRRLSE----QELLD 1712
Query: 684 VQDELRIKE-------NELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQS 736
D +++ N + LE ++A + E Q + E K ++A + +
Sbjct: 1713 ASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA-ITDAAMMAE 1771
Query: 737 SYHKQQE---ELDALKKTIEESEETLKNT-KEIQRKAEEKYEVLENKMKNAEAERERELK 792
K+Q+ L+ +KK +E++ + L++ E ++ A + + K++N E E EL
Sbjct: 1772 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELD 1831
Query: 793 DAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYES 852
QK+ A A +K+KE +T + EE + + ++ + +KSY+
Sbjct: 1832 VEQKRGAEALKGAHKYERKVKE-------MTYQAEEDHKNILRLQDLVDKLQAKVKSYKR 1884
Query: 853 QIEVMAAEVAKNKES----VNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHK 900
Q E A E A + S V EE ++ ++ +Q ++AK +V K
Sbjct: 1885 QAE-EAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQK 1935
Score = 82.0 bits (201), Expect = 3e-15
Identities = 127/673 (18%), Positives = 278/673 (41%), Gaps = 74/673 (10%)
Query: 388 SSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD 447
S+ + AT+ K ++++++ K+ + K+ QE + Q +V+
Sbjct: 846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905
Query: 448 QEALEAVKRLKEKLEAEMK----KLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARF 503
+E E + + K LEA++K +L EE L+ K+R L LK + L
Sbjct: 906 EERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDL---- 961
Query: 504 PNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL 563
L + EK+ N VK L + ++++ + E + + + +D
Sbjct: 962 -ELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD------- 1013
Query: 564 LERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPE--LQKAME 621
L+ E K + L KI+A+ + +T + +L + L + K E L+ + E
Sbjct: 1014 LQVEEDK----VNGLIKINAK-LEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE 1068
Query: 622 FVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQEL 681
+ +++N K+ ++++ + L L + L +++
Sbjct: 1069 SIM-------DLENDKQ-QIEEKLKKKEFEL--------SQLQAKIDDEQVHSLQFQKKI 1112
Query: 682 KDVQDELRIKENELRALEEELAGL-KNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHK 740
K++Q + E E+ A A + K ++ R+L++ E E + +++ + K
Sbjct: 1113 KELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNK--K 1170
Query: 741 QQEELDALKKTIEESEETLKNTKEIQRKAE-----EKYEVLENKMKNAEAERERELKDAQ 795
++ E +++ +EE+ + T RK + E E ++N ++ + + E+E + +
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN-LQRVKQKLEKEKSELK 1229
Query: 796 KKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIE 855
++D + +A SK ++ + + E+K + +QQ + +++ + +++++
Sbjct: 1230 MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD---EQQTQLIHD-LNMQKARLQ 1285
Query: 856 VMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH 915
E++ E ++TK K+ +T Q +K + E K K + L+ D
Sbjct: 1286 TQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHA-LQSSRHDC 1344
Query: 916 NISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEM 975
++ + + E E A +R L + ++T +A QR ++L+E
Sbjct: 1345 DLLREQYEEEQEAK-----------AELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 976 KEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDL--DQKKNQALNIA 1033
K+KL + L EAEE K +E K ++ +EDL D +++
Sbjct: 1394 KKKLAQR--------LQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT 1445
Query: 1034 WQKVNKDFGSIFS 1046
K ++F + +
Sbjct: 1446 LDKKQRNFDKVLA 1458
Score = 67.0 bits (162), Expect = 1e-10
Identities = 142/705 (20%), Positives = 280/705 (39%), Gaps = 73/705 (10%)
Query: 147 QGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEA--KLKEIKTILEEE-- 202
Q ++ LNM+ + + E + R+ E + + +Q T K+ +L+E+K +EEE
Sbjct: 1270 QTQLIHDLNMQKARLQTQNGELSH-RVEEKESLISQLTKSKQALTQQLEELKRQMEEETK 1328
Query: 203 ----ITPTIQKLKEE----RSSYLEYQKVMREIEHL---SRLYIAYQFLLAEDTKVRSAE 251
+ +Q + + R Y E Q+ E++ + +A E ++ E
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388
Query: 252 ELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNT 311
EL+E + KL + L E ++ + N + LEK K + G +ED + + +R +T
Sbjct: 1389 ELEEAKK---KLAQRLQEAEENTETANSKCASLEKTKQRLQG----EVEDLMRDLERSHT 1441
Query: 312 KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAE 371
+ + D K++N + E ++ + E L A +KE + ++ L ++ A + +
Sbjct: 1442 -ACATLDKKQRNF---DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 372 ALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACK------NDISKAQTEAKQAQMKLKH 425
L ++ + +S + T A K + S Q ++ + L+H
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 426 AQQELKNKQAEVKKMDSGY-RKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ 484
+ ++ Q E+ ++ S RK E E +++LK + + L +S+L+ +
Sbjct: 1558 EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEAL-------QSVLDAEIR 1610
Query: 485 LSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELV 544
D RLK+ E L ++ + + + + ++ + L KD+ L
Sbjct: 1611 SRNDALRLKKKMEGDLNEM-EIQLGHSNRQMAETQKHLRTVQGQL---KDSQLHLDDALR 1666
Query: 545 AGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQ--NLVGPDN 602
+ E L + E LLE EL+ + + + R E L + L+ N
Sbjct: 1667 SNEDLKEQLAIVERRNGLLLE--ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQN 1724
Query: 603 VHVALSLVEYKPELQKAMEFVFGTTFVCDNM-DNAKKVAFDKRIMTRTVTLGGDVFDPHG 661
+ + + + ++ + V + N + AKK D +M + D
Sbjct: 1725 TSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
Query: 662 TLSGGARSQAASILTKFQE-----LKDVQDELRIKENELRALEEEL-------AGLKNTA 709
+ + + E LK + +++ EN +R LE EL A A
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGA 1844
Query: 710 EKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKA 769
KY + ++ + EE D Q K Q ++ + K+ EE+EE R+
Sbjct: 1845 HKYERKVKEMTYQAEE-DHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRV 1903
Query: 770 EEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKE 814
+ + E EA ++ ++Q AK++ D S+KM+E
Sbjct: 1904 QHELE---------EAAERADIAESQVNKLRAKSR-DVGSQKMEE 1938
Score = 44.3 bits (103), Expect = 7e-04
Identities = 72/334 (21%), Positives = 140/334 (41%), Gaps = 33/334 (9%)
Query: 703 AGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNT 762
AGL E+ R K M + +A + + L + + K E D++ I+ + + N
Sbjct: 771 AGLLGLLEEMRDEKLVTLMTSTQA-VCRGYLMRVEFKKMMERRDSIF-CIQYNIRSFMNV 828
Query: 763 KEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAI 822
K + ++ +K+AEAE+E A K D +TK + + + + K+ E + +
Sbjct: 829 KHWPWM--NLFFKIKPLLKSAEAEKEM----ATMKEDFERTKEELARSEARRKELEEKMV 882
Query: 823 TLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVI 882
+L L+E + + E + +A + E I+ AK KE + +EE E++
Sbjct: 883 SL-LQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELV 941
Query: 883 TAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDH-------NISKHKREAEDGAAKVSKML 935
A+ ++ K + + + + + K+++ H N+S+ E+ +K++K
Sbjct: 942 -AKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK 1000
Query: 936 KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRL-QKLQEMKEKLGRNVNMRAMNVLTEA 994
K A + D K N + +L Q+ +++ L + +RA
Sbjct: 1001 KSLQ--EAHQQTLDDLQVEED-KVNGLIKINAKLEQQTDDLEGSLEQEKKLRA------- 1050
Query: 995 EERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQ 1028
DL + KR +E D +I DL+ K Q
Sbjct: 1051 -----DLERAKRKLEGDLKMSQESIMDLENDKQQ 1079
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 103 bits (258), Expect = 7e-22
Identities = 215/1005 (21%), Positives = 421/1005 (41%), Gaps = 142/1005 (14%)
Query: 78 SVSITFDNSDKKQSPL-GFEVHDEITVTRQVVIG---GRNKYLINGVNANNTRVQDLFCS 133
+V++ D ++ ++ L + H E T + I RN ++ N +D F
Sbjct: 955 TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHM----EENTGETKDEFQQ 1010
Query: 134 VGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLK 193
+ ++ L + T ++K EI IE+ +K Q+ +E A+ +
Sbjct: 1011 KMVGIDKKQDLEAKNTQTLTADVKDNEI---IEQQRKIFSLIQEKNELQQMLESVIAEKE 1067
Query: 194 EIKTILEEEITPTIQKLKEERSSYLEYQK----VMREIEH-------LSRLYIAYQFLLA 242
++KT L+E I TI+ +E R E +K V +E H LSR +
Sbjct: 1068 QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSR--TCDRLAEV 1125
Query: 243 EDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR-KDKETGGILRSLE- 300
E+ +++L+E Q +++ +QEE+SE KKI +EIE L+ K+KE L +E
Sbjct: 1126 EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI----NEIENLKNELKNKEL--TLEHMET 1179
Query: 301 DALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLH 360
+ L AQ++N + K++ E KEL+K+ + L +E++ GL
Sbjct: 1180 ERLELAQKLNENYEEV-----KSITKERKVLKELQKSFETERDHLRGYIREIE--ATGLQ 1232
Query: 361 ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQ 420
+E L A H + A + D+ K+ T+ Q +
Sbjct: 1233 TKEE--------LKIAHIHLKEHQETIDELRRSVSEKTA--QIINTQDLEKSHTKL-QEE 1281
Query: 421 MKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEK---------LEAEMKKLNYE 471
+ + H +QEL EV + QE + ++ L E+ EM++L
Sbjct: 1282 IPVLHEEQELLPNVKEVS-------ETQETMNELELLTEQSTTKDSTTLARIEMERLRLN 1334
Query: 472 ENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS 531
E +ES E+ + L+++ LK EAL + L+ ++ +L
Sbjct: 1335 EKFQES-QEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRE---------------TLAK 1378
Query: 532 VKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETL 591
++++ + L E+ D E T K + E + K P + R I E L
Sbjct: 1379 IQESQSKQEQSLNMKEK------DNETT-KIVSEMEQFK------PKDSALLR-IEIEML 1424
Query: 592 RVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFG-TTFVCDNMDN--AKKVAFDKRIMTR 648
+++ L ++ S+ + K +LQ+ E + + + +N+ AK + ++ +
Sbjct: 1425 GLSKRL--QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVA 1482
Query: 649 TVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEE--LAGLK 706
L + + L + I T ++L+ + D+L+ K E+ EE+ + +
Sbjct: 1483 HCCL-KEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQIS 1541
Query: 707 NTAEKYRQLKQQWEMKTEEADLLQT----------KLQQSSYH-----KQQEELDALKKT 751
EK +LKQ E + + LQ+ +LQ+S K++EE+ +++
Sbjct: 1542 EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEA 1601
Query: 752 IEESEETLK-NTKEIQRKAEEKYE----------VLENKMKNAEAERERELKDAQK-KLD 799
++ + LK NTKEI K +E E V E + K E E +E + QK L+
Sbjct: 1602 LQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE 1661
Query: 800 CAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIK-------SYES 852
+T+ ++ + E +E+ ++T E ++L+ + K + + + E ++ +
Sbjct: 1662 NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQE 1721
Query: 853 QIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIK----AKYAEVAKHKEQNNDSQL 908
+++++ + +++E+++K + V+++ I+ ++ A A+ K +E+ + +
Sbjct: 1722 ELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781
Query: 909 KIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQR 968
+KE I K + + K+S M KD + NA+ Q A + + K+
Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE 1841
Query: 969 LQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKS 1013
QK E+L + + +++ + E N K +E KS
Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS 1886
Score = 102 bits (253), Expect = 3e-21
Identities = 189/937 (20%), Positives = 401/937 (42%), Gaps = 116/937 (12%)
Query: 151 TKVLNMKPPEI-LSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQK 209
TK+LN + E L+ + + +Y+++ +K E+ E KLKE + E E K
Sbjct: 488 TKLLNQENIESELNSLRADYDNLVLDYEQLRTEK--EEMELKLKEKNDLDEFEALERKTK 545
Query: 210 LKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEEL-S 268
+E E + ++H + Q L E+ E L+E +D++ KLQE + S
Sbjct: 546 KDQEMQLIHEISNLKNLVKHAE---VYNQDL--ENELSSKVELLREKEDQIKKLQEYIDS 600
Query: 269 ENDKKIKA-LNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACE 327
+ + IK L++ +E +E K + ++L DA E ++ K +SAF L+ +NL
Sbjct: 601 QKLENIKMDLSYSLESIEDPKQMK-----QTLFDA--ETVALDAKRESAF-LRSENL--- 649
Query: 328 ESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGL 387
EL++ M E + T E +++ L A ++ + L +A FN ++ L
Sbjct: 650 -----ELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA---FNEITK-L 700
Query: 388 SSNEDG-------AEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKM 440
+S DG L G++ + +++K + E +A + ELK+ +EV+++
Sbjct: 701 TSLIDGKVPKDLLCNLELEGKITDLQKELNK-EVEENEALREEVILLSELKSLPSEVERL 759
Query: 441 DSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALL 500
+ E L + K+KL +E+ ++E++ + LLE+ + D+ + Y++
Sbjct: 760 RKEIQDKSEELHIITSEKDKLFSEVV---HKESRVQGLLEEIGKTKDDLATTQSNYKSTD 816
Query: 501 ARFPNLRFAYKDPEKNW------NRNCVKGLV-ASLISVKDTSATTALELVAGERLYNVV 553
F N + + D E+ + N + +V S + K S+ AL+ + +
Sbjct: 817 QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ 876
Query: 554 VDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK 613
T ++L E +LK + + + + + E + + L + +L + K
Sbjct: 877 EKTREVQERLNEMEQLKEQ---LENRDSTLQTVEREKTLITEKL--QQTLEEVKTLTQEK 931
Query: 614 PELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDP-HGTLSGGARSQAA 672
+L++ E + D K D TV + D + L + Q
Sbjct: 932 DDLKQLQE------SLQIERDQLKSDIHD------TVNMNIDTQEQLRNALESLKQHQET 979
Query: 673 SILTKFQELKDVQDELRIKENELRALEE---ELAGLKNTAEKYRQLKQQWEMKTEEADLL 729
K + ++V L ++EN +E ++ G+ + + Q ++ +++
Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 730 QTKLQQSSYHKQQEELDALKKTI------------EESEETLKNTKEIQRKAEE--KYEV 775
+ + + S +++ EL + +++ E E T++N +E++ +E K +
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 776 LENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTS 835
+ + KN ++E EL +L + K S++++EKQQ++ + E+ E++++
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK--- 1156
Query: 836 YKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEV---TKQKEVI--------TA 884
++E + +K+ E +E M E + + +N+ EEV TK+++V+ T
Sbjct: 1157 -INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETE 1215
Query: 885 QDTV---IKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKV---------- 931
+D + I+ A + KE+ + + +KE I + +R + A++
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSH 1275
Query: 932 SKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVL 991
+K+ ++ ++ E+ L PN + + +E L+ L E R
Sbjct: 1276 TKLQEEIPVLHEEQELL--PNVK---EVSETQETMNELELLTEQSTTKDSTTLARIEMER 1330
Query: 992 TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQ 1028
E++ + ++ + + ++ + T E L+ K +Q
Sbjct: 1331 LRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQ 1367
Score = 90.1 bits (222), Expect = 1e-17
Identities = 171/938 (18%), Positives = 396/938 (42%), Gaps = 155/938 (16%)
Query: 152 KVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTIL--EEEITPTIQK 209
K+ ++ E I+E + + +I + +EK KL+E +L E+E+ P +++
Sbjct: 1238 KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKE 1297
Query: 210 LKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSE 269
+ E Q+ M E+E LL E + + + L ++ + ++L E+ E
Sbjct: 1298 VSET-------QETMNELE-----------LLTEQSTTKDSTTLARIEMERLRLNEKFQE 1339
Query: 270 NDKKIKALNHEIEELEKRKDK---ETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLAC 326
+ ++IK+L E + L+ K+ + + + + LA+ Q +K + + ++K+K+
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD--- 1396
Query: 327 EESKR--KELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS 384
E+ + E+E+ +DS L E++ + GL + S+ + +++A + +
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRI---EIEML--GLSKRLQESHDEMKSVAKEKDDLQRLQ 1451
Query: 385 AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGY 444
L S D K +I + + + + +LK A LK ++ + ++
Sbjct: 1452 EVLQSESD-----------QLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL 1500
Query: 445 RKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFP 504
+ + + +++ +LEA KL +NK + + EK Q + I ++ E E +
Sbjct: 1501 SEKETEISTIQK---QLEAINDKL---QNKIQEIYEKEEQFN--IKQISEVQEKV----- 1547
Query: 505 NLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLL 564
N +K+ K KD SA ++E E + E +
Sbjct: 1548 NELKQFKEHRK----------------AKD-SALQSIESKMLELTNRLQESQEEIQIMIK 1590
Query: 565 ERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVF 624
E+ E+KR + + + + E VA+ + + L + +K E
Sbjct: 1591 EKEEMKRVQEALQIERDQLKENTKEI--VAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648
Query: 625 GTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDV 684
N + + + +T+ + H L + S+ + +L+ V
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQIL---------HENLE-----EMRSVTKERDDLRSV 1694
Query: 685 QDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEE 744
++ L+++ ++L+ L+ T R L++Q E+K L + QE
Sbjct: 1695 EETLKVERDQLKE------NLRETIT--RDLEKQEELKIVHMHLKE----------HQET 1736
Query: 745 LDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLD----C 800
+D L+ + E + N ++ + + + + K++ LK+ Q+ +D
Sbjct: 1737 IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGI 1796
Query: 801 AKTKADA----------SSKKMKEKQQEVEA-----ITL------------ELEELKRE- 832
K D S+ K++EK QE++A ITL E+E+LK++
Sbjct: 1797 VSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQI 1856
Query: 833 ----HTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTV 888
T K ++E +N A K +E+ E+ + V K ++++ + +E + +++ +
Sbjct: 1857 KDQSLTLSKLEIENLNLAQKLHENLEEMKS--VMKERDNLRRVEETLKLERDQLKESLQE 1914
Query: 889 IKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLF 948
KA+ E+ +++ +++ KE + K + + + ++S + KD D E
Sbjct: 1915 TKARDLEI---QQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKK 1971
Query: 949 GQPNSAYDFKTNNPKE----AGQRLQKLQEMKEKL-GRNVNMRAMNVLT-EAEERYNDLM 1002
Q + + KE + +++ +++++K++ +N++M+++ + + ++ ++ +
Sbjct: 1972 IQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESL 2031
Query: 1003 KKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKD 1040
++ RIV ++ ++ E L +++Q + + + +D
Sbjct: 2032 EEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD 2069
Score = 87.0 bits (214), Expect = 9e-17
Identities = 175/901 (19%), Positives = 356/901 (39%), Gaps = 129/901 (14%)
Query: 183 KTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLY--IAYQFL 240
K +K ++ L +KT L + +K +E + E +++ ++E+ + +
Sbjct: 852 KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT 911
Query: 241 LAEDTKVRSAEELKEM---QDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILR 297
L + ++ EE+K + +D + +LQE L ++K+ H+ + ++ L
Sbjct: 912 LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971
Query: 298 SLEDALAEAQRVNTKSQSAFDLKKKNLACEESK---RKELEKNMVEDSKTLAAKEKEVKK 354
SL+ + +NT + +NL EE+ + E ++ MV K + K +
Sbjct: 972 SLKQ---HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT 1028
Query: 355 ITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQT 414
+T A KD E + ++ F+ + + + E+ +A + K D+ +
Sbjct: 1029 LT--------ADVKDNEIIEQQRKIFSLIQEK-NELQQMLESVIA-EKEQLKTDLKENIE 1078
Query: 415 EAKQAQMKLKHAQQELKNKQAEV-KKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEEN 473
+ Q +L+ ELK +Q V ++ + +K+ E RL E E +K +
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Query: 474 KEESLLEKRRQLSRDIGRLKETYEALLARFPN--LRFAYKDPEK-------NWNRNCVKG 524
K++ LL + ++S ++ E E L N L + + E+ N N VK
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEI-ENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197
Query: 525 LVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA- 583
+ +K+ + E + L + + E TG + E ELK + + ++ +
Sbjct: 1198 ITKERKVLKELQKSFETER---DHLRGYIREIEATGLQTKE--ELKIAHIHLKEHQETID 1252
Query: 584 ---RCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVA 640
R ++ +T ++ N + H L E P L + E + N K+V+
Sbjct: 1253 ELRRSVSEKTAQII-NTQDLEKSHTKLQ--EEIPVLHEEQEL----------LPNVKEVS 1299
Query: 641 FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQE--------------LKDVQD 686
+ M L T + + KFQE LK +++
Sbjct: 1300 ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359
Query: 687 ELRIKENELRA-LEEELAGLKNTAEKYRQLKQQWEMKTEEADLL----QTKLQQSSYHKQ 741
L +K ++L+ + E LA ++ + K Q E E ++ Q K + S+ +
Sbjct: 1360 ALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRI 1419
Query: 742 QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA----------EREREL 791
+ E+ L K ++ES + +K+ + + + EVL+++ + E E EL
Sbjct: 1420 EIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL 1479
Query: 792 KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYE 851
K A L + + + EK+ E+ I ++QLEA+N+ ++
Sbjct: 1480 KVAHCCLKEQEETINELRVNLSEKETEISTI--------------QKQLEAINDKLQ--- 1522
Query: 852 SQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK 911
NK QE K+++ Q + ++ K E+ + KE ++
Sbjct: 1523 -----------------NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565
Query: 912 ELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRL-Q 970
++ + + ++ ++ M+K E+ + A + + KE + +
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIK-------EKEEMKRVQEALQIERDQLKENTKEIVA 1618
Query: 971 KLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL 1030
K++E +EK + + M A+N E +E+ ++ K E K L IE + + Q L
Sbjct: 1619 KMKESQEKEYQFLKMTAVN---ETQEKMCEIEHLKEQFETQKLN-LENIETENIRLTQIL 1674
Query: 1031 N 1031
+
Sbjct: 1675 H 1675
Score = 78.6 bits (192), Expect = 3e-14
Identities = 171/814 (21%), Positives = 329/814 (40%), Gaps = 131/814 (16%)
Query: 262 KLQEELSENDKKIKALNH--EIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDL 319
+L+ E E + K+K N E E LE++ K+ E Q ++ S
Sbjct: 516 QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ------------EMQLIHEISNL---- 559
Query: 320 KKKNLACE-ESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQ 378
KNL E ++LE + + L KE ++KK+ + + + Q+ N +
Sbjct: 560 --KNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS-QKLENIKMD------- 609
Query: 379 HFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEV- 437
+S L S ED QM D +AK+ L+ ELK K E+
Sbjct: 610 ----LSYSLESIEDPK------QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELA 659
Query: 438 ---KKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKE 494
K+M++ + Q LEA K+++ LE E++ E K SL++ + + +D+
Sbjct: 660 TTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGK--VPKDL----- 712
Query: 495 TYEALLARFPNLRFAYK--DPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNV 552
NL K D +K N+ V++ A E++ L ++
Sbjct: 713 --------LCNLELEGKITDLQKELNKE-----------VEENEALRE-EVILLSELKSL 752
Query: 553 VVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNL--VGPDNVHVALSLV 610
+ E K++ ++ E T +K+ + + E+ RV L +G +A +
Sbjct: 753 PSEVERLRKEIQDKSEELHIITS-EKDKLFSEVVHKES-RVQGLLEEIGKTKDDLATTQS 810
Query: 611 EYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQ 670
YK Q+ F T D K V + M + + + G +++
Sbjct: 811 NYKSTDQEFQNF---KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
Query: 671 AASILTKFQELKDVQDELRIKENELRALEEELAGLKNT-----------AEKYRQLKQQW 719
+ K QEL++ E++ + NE+ L+E+L +T EK +Q ++
Sbjct: 868 LSY---KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924
Query: 720 EMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES-------EETLKNTKEIQRKAEEK 772
+ T+E D L+ +LQ+S Q E D LK I ++ +E L+N E ++ +E
Sbjct: 925 KTLTQEKDDLK-QLQESL----QIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979
Query: 773 YEVLENKMKNAEA------ERERELKDA-QKKLDCAKTKADASSKKMKE-----KQQEVE 820
L++K+ + E E KD Q+K+ K D +K + K E+
Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 821 AITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKE 880
++ L +E +Q LE+V + ++ ++ +N+E + +E+ KQ+E
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 881 VITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDW 940
++ + K E+++ ++ + + K+KE + + +++ + ++S+M K +
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
Query: 941 I-NAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYN 999
I N + L + + +T +RL+ Q++ E N + +T+ +
Sbjct: 1160 IENLKNELKNKELTLEHMET-------ERLELAQKLNE------NYEEVKSITKERKVLK 1206
Query: 1000 DLMKKKRIVENDKSKILTTIEDLDQKKNQALNIA 1033
+L K + + IE + + L IA
Sbjct: 1207 ELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240
Score = 75.5 bits (184), Expect = 3e-13
Identities = 147/795 (18%), Positives = 326/795 (41%), Gaps = 91/795 (11%)
Query: 282 EELEKRKDKETGGILRSLEDALAEAQ-RVNTKSQSAFDLKKKNLA--CEESKRKELEKNM 338
E L KR KE + + LE+ E + + K Q A L++K+L + K + L + +
Sbjct: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRML 401
Query: 339 VEDSKTLAAKE---KEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNE---- 391
V S +E K +++T L + + N + + + LS N
Sbjct: 402 VTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI 461
Query: 392 DGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEAL 451
D + + + + +S+ + + ++ + EL + +A+ + Y
Sbjct: 462 DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDY------- 514
Query: 452 EAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYK 511
E ++ KE++E ++K+ N + E LE++ + +++ L+ NL+ K
Sbjct: 515 EQLRTEKEEMELKLKEKN--DLDEFEALERKTKKDQEM--------QLIHEISNLKNLVK 564
Query: 512 DPEKNWNRNCVKGLVAS--LISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGEL 569
E +N++ L + L+ K+ E + ++L N+ +D + + + + ++
Sbjct: 565 HAEV-YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623
Query: 570 KRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFV 629
K+ A +A + R + L + L L E EL + + +
Sbjct: 624 KQTL-------FDAETVALDAKRESAFLRSEN-----LELKEKMKELATTYKQMENDIQL 671
Query: 630 CDNMDNAKK---VAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD 686
+ AKK V +K + + ++ + G L ++ D+Q
Sbjct: 672 YQSQLEAKKKMQVDLEKELQSAF----NEITKLTSLIDGKVPKDLLCNLELEGKITDLQK 727
Query: 687 ELRIKENELRALEEE---LAGLKNTAEKYRQLKQQWEMKTEEADLLQT---KLQQSSYHK 740
EL + E AL EE L+ LK+ + +L+++ + K+EE ++ + KL HK
Sbjct: 728 ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787
Query: 741 Q-------------QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAER 787
+ +++L + + +++ +N K + E+KY+++ + + E
Sbjct: 788 ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
Query: 788 ERELKDAQK---KLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVN 844
K+AQK L KT+ +++++EK +EV+ E+E+L K+QLE +
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL-------KEQLENRD 900
Query: 845 EAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNN 904
+++ E + ++ ++ + E V +E K++ + +++ N
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 905 DSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE 964
D+Q +++ ++ +H+ +K+S+ R+L + N+ K
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISE--------EVSRNLHMEENTGETKDEFQQKM 1012
Query: 965 AGQRLQKLQEMKEKLGRNVNMRAM-NVLTEAEERYNDLMKKKRIVENDKSKILTTIEDL- 1022
G + K Q+++ K + + N + E + + L+++K ++ ++ E L
Sbjct: 1013 VG--IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLK 1070
Query: 1023 -DQKKNQALNIAWQK 1036
D K+N + I Q+
Sbjct: 1071 TDLKENIEMTIENQE 1085
Score = 72.8 bits (177), Expect = 2e-12
Identities = 178/956 (18%), Positives = 375/956 (39%), Gaps = 153/956 (16%)
Query: 149 RITKVLNMKPPEILSMIEEAAGTRMYEYK--------KIAAQKTIEKKEAKLKEIKTILE 200
R+T++L+ E+ S+ +E R E K ++TI + K +E+K +
Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHM 1728
Query: 201 --EEITPTIQKLK---EERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKE 255
+E TI KL+ E+++ E + +++EH + A + E+ ++ LKE
Sbjct: 1729 HLKEHQETIDKLRGIVSEKTN--EISNMQKDLEHSNDALKAQDLKIQEELRIAHMH-LKE 1785
Query: 256 MQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI------LRSLEDALAEAQRV 309
Q+ + KL+ +SE K+ + ++E + ++ + L +L+ + E Q+
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK 1845
Query: 310 NTKSQ-------------SAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKIT 356
++ + S +++ NLA + + E K+++++ L E+ +K
Sbjct: 1846 VSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLER 1905
Query: 357 DGL-HALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTE 415
D L +LQE +D E QQ LS L ++ IS Q +
Sbjct: 1906 DQLKESLQETKARDLEI----QQELKTARM-LSKEHKETVDKLREKISEKTIQISDIQKD 1960
Query: 416 AKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKE 475
+++ +L+ QEL+ K+ ++ ++ + + +++LK++ EA+ +
Sbjct: 1961 LDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM------- 2013
Query: 476 ESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDT 535
+S+ QL++ +L E+ E +R K+ R+ ++ + SL +D
Sbjct: 2014 QSVRMDNFQLTK---KLHESLE-------EIRIVAKE------RDELRRIKESLKMERDQ 2057
Query: 536 SATTALELVAGERLYNVVVD------------TEVTGKKLLERGELKRRYTIIP-----L 578
T E++A +R + V TE +K EL +RY+ + L
Sbjct: 2058 FIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL 2117
Query: 579 NKIS------ARCIAPETLRVAQNLVGP------------DNVHVALSLVEYKPELQKAM 620
N++S ++RV NL P N ++ +L+ +
Sbjct: 2118 NRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVL 2177
Query: 621 EFVFG---------TTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQA 671
+V F D +D +K K ++ + L D P L +Q
Sbjct: 2178 SYVTKIKEEQHESINKFEMDFIDEVEK---QKELLIKIQHLQQDCDVPSRELRDLKLNQN 2234
Query: 672 ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQT 731
+ + + LKD E+E +++ E + + ++ Q ++W + + L+
Sbjct: 2235 MDLHIE-EILKD------FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKN 2287
Query: 732 KLQQS----------------SYHKQQEELDALKKTI-EESEETLKNTKEIQRKAEEKYE 774
+Q+ + + E + TI +E E+ LK+ KE K + Y+
Sbjct: 2288 GIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQ 2347
Query: 775 VLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHT 834
L+ + A + K +++K++E + + + +
Sbjct: 2348 TLKTSL--ASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405
Query: 835 SYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYA 894
+++LE N+ I ++++ + K KE++ Q++V + + +K K
Sbjct: 2406 KMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLV 2465
Query: 895 EVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSA 954
++ K +N KE + IS K E +V ++L++ N R Q S
Sbjct: 2466 KIDLEKMKN------AKEFEKEISATKATVE-YQKEVIRLLRE----NLRRSQQAQDTSV 2514
Query: 955 YDFKT-----NNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKK 1005
T N P G +Q K + ++ ++R +++ +++ L+K+K
Sbjct: 2515 ISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQK 2570
Score = 71.6 bits (174), Expect = 4e-12
Identities = 167/878 (19%), Positives = 362/878 (41%), Gaps = 142/878 (16%)
Query: 156 MKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERS 215
+K E + ++EA + K+ + + KE++ KE + + + T +K+ E
Sbjct: 1589 IKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEH 1648
Query: 216 SYLEYQKVMREIEHLSRLYIAYQFLLAEDTK-----------VRSAEELKEMQDKVIK-- 262
+++ +E++ I +L E+ + +RS EE +++ +K
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708
Query: 263 LQEELS---ENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDL 319
L+E ++ E +++K ++ ++E ++ DK GI+ + ++ Q+ S A L
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDK-LRGIVSEKTNEISNMQKDLEHSNDA--L 1765
Query: 320 KKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ-EASNKDAEALAAAQQ 378
K ++L +E R ++ E +T+ V + TD L +Q + N +A+ Q+
Sbjct: 1766 KAQDLKIQEELR-IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQE 1824
Query: 379 HFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTE-AKQAQMKLKHAQQELKNKQAEV 437
L +NE Q++ K D+++ Q + ++ Q+K + Q L + E+
Sbjct: 1825 --------LKANEH--------QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEI 1868
Query: 438 KKMDSGYRKDQEALEAVKRLKE-----------KLEAEMKKLNYEENKEESL-----LEK 481
+ ++ + + E +KE KLE + K + +E K L L+
Sbjct: 1869 ENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKT 1928
Query: 482 RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTAL 541
R LS++ KET + L + D +K+ +++ KD
Sbjct: 1929 ARMLSKE---HKETVDKLREKISEKTIQISDIQKDLDKS------------KDELQKKIQ 1973
Query: 542 ELVAGE-RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGP 600
EL E +L V D ++ KK+ E +LK+++ +S + + + ++ + L
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQF---EAQNLSMQSVRMDNFQLTKKL--H 2028
Query: 601 DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
+++ + + + EL++ E + M+ + +A + ++ R V
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESL--------KMERDQFIATLREMIARD-RQNHQVKPEK 2079
Query: 661 GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
LS G + S+ K +K++ ++ L L+ E ++L + +
Sbjct: 2080 RLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVK 2139
Query: 721 -------MKTEEADLLQTKLQQSS--YHK---------------QQEELDALKK------ 750
++T+ + L T Q+ S +H+ ++E+ +++ K
Sbjct: 2140 ANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFI 2199
Query: 751 -TIEESEETLKNTKEIQRKAE-EKYEVLENKM-KNAEAERERELKD-AQKKLDCAKTKAD 806
+E+ +E L + +Q+ + E+ + K+ +N + E LKD ++ + KT+
Sbjct: 2200 DEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQ 2259
Query: 807 ASSKKMKEKQQEVEA---ITLELEELKREHTSYKQQLEAVNE-------AIKSYESQIEV 856
KE Q +E ++E+LK ++ VN AI + ++ E
Sbjct: 2260 QVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEE 2319
Query: 857 MAAEVAKNKESVNKAQEEVTKQ--KEVITAQDTVIKAKYAEVAKHKEQNNDSQL------ 908
+A ++K E K+ +E ++ K T + ++ A A+V + N + +
Sbjct: 2320 RSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSL--ASGAQVNPTTQDNKNPHVTSRATQ 2377
Query: 909 ----KIKELDHNISKHKREAEDGAAKVSKMLKDYDWIN 942
KI+EL++++ + K A +K+ KM K+ + N
Sbjct: 2378 LTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415
Score = 55.1 bits (131), Expect = 4e-07
Identities = 80/408 (19%), Positives = 169/408 (41%), Gaps = 63/408 (15%)
Query: 692 ENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEA-DLLQTKLQQSSYHKQQE-----EL 745
E+EL +L + L E+ R K++ E+K +E DL + + + K QE E+
Sbjct: 497 ESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEI 556
Query: 746 DALKKTIEESE-------ETLKNTKEIQRKAEEKYEVLEN-----KMKNAEAERERELKD 793
LK ++ +E L + E+ R+ E++ + L+ K++N + + L+
Sbjct: 557 SNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLES 616
Query: 794 AQKKLDCAKTKADASSKKMKEKQQE--VEAITLELEELKRE-HTSYKQQLEAVNEAIKSY 850
+ +T DA + + K++ + + LEL+E +E T+YKQ + I+ Y
Sbjct: 617 IEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ----MENDIQLY 672
Query: 851 ESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQ-------DTVIKAKYAEVAK--HKE 901
+SQ+E ++ + A E+TK +I + + ++ K ++ K +KE
Sbjct: 673 QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKE 732
Query: 902 QNNDSQLK--------IKELDHNISKHKREAEDGAAKVSKMLKDYDWINAE--------- 944
+ L+ +K L + + ++E +D + ++ + + D + +E
Sbjct: 733 VEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQ 792
Query: 945 --RHLFGQPNSAYDFKTNNPKEAGQRLQKLQ------EMKEKL----GRNVNMRAMNVLT 992
G+ +N K Q Q + E K K+ +N +N+
Sbjct: 793 GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK 852
Query: 993 EAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKD 1040
EA++ + L K + ++ ++ ++ N+ + Q N+D
Sbjct: 853 EAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Score = 48.1 bits (113), Expect = 5e-05
Identities = 72/331 (21%), Positives = 133/331 (40%), Gaps = 49/331 (14%)
Query: 116 LINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYE 175
L NG+ N R+ C V NN RI ++N + EE + T E
Sbjct: 2285 LKNGIQKENDRI----CQVNNFFNN--------RIIAIMNES-----TEFEERSATISKE 2327
Query: 176 YKKIAAQKTIEKKEAKL----KEIKTILEE--EITPTIQKLKEERSSYLEYQKVMREIEH 229
+++ K++++K KL + +KT L ++ PT Q K + Q +I
Sbjct: 2328 WEQDL--KSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE 2385
Query: 230 LSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEK--R 287
L E++ + E + K+IK+Q+EL + I L ++ E K
Sbjct: 2386 L------------ENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLE 2433
Query: 288 KDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKR-KELEKNMVEDSKTLA 346
K KET ++ L+D +A + + +K + E+ K KE EK + T+
Sbjct: 2434 KTKET---IQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVE 2490
Query: 347 AKEKEVKKITDGLHALQEASNKDAEALAAAQQHFN---AVSAGLSSNEDGAEATLAGQMM 403
+++ ++ + + L Q+A + + Q N G ++ L + +
Sbjct: 2491 YQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHI 2550
Query: 404 ACKNDISKAQTEAKQAQMKLKHAQQELKNKQ 434
+ +ISK + +Q + +K + L N Q
Sbjct: 2551 RLEKEISKLK---QQNEQLIKQKNELLSNNQ 2578
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 103 bits (258), Expect = 7e-22
Identities = 180/850 (21%), Positives = 364/850 (42%), Gaps = 102/850 (12%)
Query: 154 LNMKPPEILSMIEEAAGTRMYEYKKIA-AQKTIEKKEAKLKEIKTILEEEITPTIQKLKE 212
L K E+ + IEE E A A+K +L+EI LEE T +++
Sbjct: 1107 LQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVEL 1166
Query: 213 ERSSYLEYQKVMREIEHLSRLYIAYQFLLAE---DTKVRSAEELKEMQDKVIKLQEELSE 269
+ E+QK+ R++E + + A L + D+ E++ +Q KL++E SE
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226
Query: 270 NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEES 329
+ L+ E + K K + RSLED ++E + + Q + A ++
Sbjct: 1227 LKMETDDLSSNAEAISKAKGN-LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQT 1285
Query: 330 KRKELEKNMVED----SKTLAAKEKEVKKITDGLHALQE---ASNKDAEALAAAQQHFNA 382
+ E + + E S+ +K+ ++I + H L+E A N A AL +++ +
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDL 1345
Query: 383 VSAGLSSNEDGAEATLAGQMMACKNDIS----KAQTEAKQAQMKLKHAQQELKNKQAEVK 438
+ ++G +A L + ++++ K +T+A Q +L+ A+++L + E +
Sbjct: 1346 LREQYEEEQEG-KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1404
Query: 439 KMDSGYRKDQEALEAVK-RLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYE 497
+ +LE K RL+ ++E M + +L +K+R + + K+ YE
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464
Query: 498 ALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTE 557
A L + K+ + L L VK+ + L+ + R N + E
Sbjct: 1465 ETQAE---LEASQKES---------RSLSTELFKVKNVYEES-LDQLETLRRENKNLQQE 1511
Query: 558 VTG--KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDN---VHVALSLVEY 612
++ +++ E G+ I +C L A+ + + + + L L +
Sbjct: 1512 ISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV 1571
Query: 613 KPELQKAM--------EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLG------GDVFD 658
K E+ + + + T V + M + D I +R L GD+ +
Sbjct: 1572 KSEVDRKIAEKDEEIDQLKRNHTRVVETMQST----LDAEIRSRNDALRVKKKMEGDLNE 1627
Query: 659 PHGTLSGGARSQAASI--------LTKFQEL---------KDVQDELRIKENELRALEEE 701
L+ R A S+ + K +L +D++++L I E L+ E
Sbjct: 1628 MEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAE 1687
Query: 702 LAGLKNTAEKYRQLKQQWEMK----TEEADLLQTKLQQ--SSYHKQQEELDALKKTIEES 755
+ L T E+ + ++ E + +E LL T+ ++ K + ++ L+ +EE
Sbjct: 1688 IEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEV 1747
Query: 756 EETLKNTKEIQRKAEEKYEVLENKMK-----NAEAER-----ERELKDAQKKLDCAKTKA 805
+ +N +E +KA ++ ++K +A ER E+ +KD Q +LD A+ A
Sbjct: 1748 IQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1807
Query: 806 DASSKKMKEKQQEVEAITLELE-ELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
KK +K +EA ELE E++ E K+ EAV + ++ +E +++ + + ++
Sbjct: 1808 LKGGKKQIQK---LEARVRELEGEVENEQ---KRNAEAV-KGLRKHERRVKELTYQTEED 1860
Query: 865 KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREA 924
+++V + Q+ V K + +K+ + + +EQ+N + K ++L H + + + A
Sbjct: 1861 RKNVLRLQDLVDKLQ-------AKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERA 1913
Query: 925 EDGAAKVSKM 934
+ ++V+K+
Sbjct: 1914 DIAESQVNKL 1923
Score = 100 bits (248), Expect = 1e-20
Identities = 138/691 (19%), Positives = 284/691 (41%), Gaps = 110/691 (15%)
Query: 388 SSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD 447
S+ + AT+ + K++++K++ + K+ + K+ +E + Q +V+
Sbjct: 845 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADA 904
Query: 448 QEALEAVKRLKEKLEAEMKKLNYEENKEE----SLLEKRRQLSRDIGRLKETYEALLARF 503
+E E + + K +LEA++K++ +EE L K+R+L + LK+ + L
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL---- 960
Query: 504 PNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVD---TEVTG 560
L A + EK+ N VK L + + +T A + E A + + +D E
Sbjct: 961 -ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDK 1019
Query: 561 KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAM 620
+L + + K + L +L + L + L K +L+ +
Sbjct: 1020 VNILTKAKTKLEQQVDDLE---------GSLEQEKKL--------RMDLERAKRKLEGDL 1062
Query: 621 EFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQE 680
+ +T +M+N K+ D+++ + + +++++K ++
Sbjct: 1063 KLAQESTM---DMENDKQ-QLDEKLEKK-------------------EFEISNLISKIED 1099
Query: 681 LKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHK 740
+ V+ +L+ K EL+A EEL E++ E A + + Q+S +
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGE---------------EIEAERASRAKAEKQRSDLSR 1144
Query: 741 QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDC 800
EL+ + + +EE+ E+ +K E +++ L ++ A + E + +KK
Sbjct: 1145 ---ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK--- 1198
Query: 801 AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860
AD S ++ E+ ++ + +LE+ K E L + EAI + +E M
Sbjct: 1199 ---HAD-SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRS 1254
Query: 861 VAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNND--SQL---------K 909
+ + +EE + +TAQ ++ + E ++ ++ + SQL +
Sbjct: 1255 LEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQ 1314
Query: 910 IKELDHNISKHKREAEDGAAKVSKMLKDYDWI------------NAERHLFGQPNSAYDF 957
I+EL H + + + A + D D + +R L + +
Sbjct: 1315 IEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1374
Query: 958 KTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILT 1017
+T +A QR ++L+E K+KL + L EAEE + K +E K ++
Sbjct: 1375 RTKYETDAIQRTEELEEAKKKLAQR--------LQEAEEHVEAVNAKCASLEKTKQRLQN 1426
Query: 1018 TIED--LDQKKNQALNIAWQKVNKDFGSIFS 1046
+ED LD +++ A A K ++F + S
Sbjct: 1427 EVEDLMLDVERSNAACAALDKKQRNFDKVLS 1457
Score = 94.4 bits (233), Expect = 6e-19
Identities = 179/949 (18%), Positives = 390/949 (41%), Gaps = 113/949 (11%)
Query: 149 RITKVLNMKPPEILSMIEEAAG-----TRMYEYKKIAA---QKTIEKKEAK------LKE 194
++ K + ++ ++ EE AG ++ + KK Q+T++ +A+ L +
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025
Query: 195 IKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL-AEDTKVRSAEEL 253
KT LE+++ L++E+ ++ ++ R++E L +A + + E+ K + E+L
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE--GDLKLAQESTMDMENDKQQLDEKL 1083
Query: 254 K----EMQDKVIKLQEELS---ENDKKIKALNHEIEELEK----------RKDKETGGIL 296
+ E+ + + K+++E + + KKIK L IEEL + + +K+ +
Sbjct: 1084 EKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLS 1143
Query: 297 RSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEK------ 350
R LE+ + + + +L KK A + R++LE+ ++ +AA K
Sbjct: 1144 RELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSM 1203
Query: 351 -EVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDI 409
E+ + D L +++ K+ L ++ + +S A+ L + ++ +
Sbjct: 1204 AELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK----AKGNLEKMCRSLEDQV 1259
Query: 410 SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLN 469
S+ +T+ ++ Q + + Q E + + + + R K+ ++++L
Sbjct: 1260 SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELK 1319
Query: 470 Y---EENKEESLLEKRRQLSR-DIGRLKETYEALLARFPNLRFAYKDPEK---NWNRNCV 522
+ EE K ++ L Q SR D L+E YE L+ A W
Sbjct: 1320 HQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE 1379
Query: 523 KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
+ +++ A L E V + +K +R + + ++ + + +
Sbjct: 1380 TDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSN 1439
Query: 583 ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFD 642
A C A L Q E + EL+ + + + + N + + D
Sbjct: 1440 AACAA---LDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 1496
Query: 643 --KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELR-ALE 699
+ + L ++ D ++ G + + EL+ ++ ++ ++ E++ ALE
Sbjct: 1497 QLETLRRENKNLQQEISDLTEQIAEGGK--------QIHELEKIKKQVEQEKCEIQAALE 1548
Query: 700 EELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETL 759
E A L++ K +++ + E D ++ EE+D LK+ ET+
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVD--------RKIAEKDEEIDQLKRNHTRVVETM 1600
Query: 760 KNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV 819
++T + + ++ ++ KM E +L + + +L+ A A S + + Q +
Sbjct: 1601 QSTLDAEIRSRNDALRVKKKM-------EGDLNEMEIQLNHANRLAAESLRNYRNTQGIL 1653
Query: 820 EAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEV---T 876
+ L L++ R K+QL V +++IE + A + + + S A++E+ +
Sbjct: 1654 KETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDAS 1713
Query: 877 KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLK------IKELDHNISKHKREAEDGAAK 930
++ +++ Q+T + K K +N+ SQL+ I+E + K K+ D A
Sbjct: 1714 ERVQLLHTQNTSLIN-----TKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMM 1768
Query: 931 VSKMLKDYDWI--------NAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRN 982
++ K+ D N E+ + + + + K +++QKL+ +L
Sbjct: 1769 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE 1828
Query: 983 V------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQK 1025
V N A+ L + E R +L + E D+ +L ++DL K
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKELTYQ---TEEDRKNVL-RLQDLVDK 1873
Score = 93.6 bits (231), Expect = 1e-18
Identities = 156/816 (19%), Positives = 338/816 (41%), Gaps = 83/816 (10%)
Query: 238 QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDK------E 291
+F +D +S + KE+++K++ L +E ++ ++++ + + E+R ++ +
Sbjct: 858 EFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQ 917
Query: 292 TGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL--ACEESKR--KELEKNMVEDSKTLAA 347
++ + + E + +N + KK+ L C E K+ +LE + + K A
Sbjct: 918 LEAKIKEVTERAEEEEEINAE----LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 973
Query: 348 KEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKN 407
E +VK +T+ + L E K ++ A Q+ L + ED N
Sbjct: 974 TENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKV------------N 1021
Query: 408 DISKAQTEAKQAQMKLKHAQQELKNKQAEV----KKMDSGYRKDQEALEAVKRLKEKLEA 463
++KA+T+ +Q L+ + ++ K + ++ +K++ + QE+ ++ K++L+
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE 1081
Query: 464 EMKKLNYEENKEESLLEKRR----QLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR 519
+++K +E + S +E + QL + I L+ E L R + EK
Sbjct: 1082 KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ-RS 1140
Query: 520 NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKL---LERGELKRRYTII 576
+ + L +++ T+ ++ ++ E +KL LE L+ +
Sbjct: 1141 DLSRELEEISERLEEAGGATSAQVELNKK-------REAEFQKLRRDLEEATLQHEAMVA 1193
Query: 577 PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
L K A +A ++ DN L V+ K E +K+ E T + N +
Sbjct: 1194 ALRKKHADSMAELGEQI-------DN----LQRVKQKLEKEKS-ELKMETDDLSSNAEAI 1241
Query: 637 KKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELR 696
K + M R++ D T + + + L+ E + +E
Sbjct: 1242 SKAKGNLEKMCRSLE---DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKD 1298
Query: 697 ALEEELAGLKN-TAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEES 755
AL +L+ K + ++ +LK Q E +T+ + L LQ S + + D L++ EE
Sbjct: 1299 ALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSS-----RHDCDLLREQYEEE 1353
Query: 756 EETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKAD--------- 806
+E + KA + K + +R EL++A+KKL +A+
Sbjct: 1354 QEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAK 1413
Query: 807 -ASSKKMKEK-QQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKN 864
AS +K K++ Q EVE + L++E + ++ ++ + ++ + E AE+ +
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS 1473
Query: 865 KESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKE---LDHNISKHK 921
++ E+ K K V ++ E +++ +D +I E H + K K
Sbjct: 1474 QKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK 1533
Query: 922 REAEDGAAKVSKMLKDYD--WINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKL 979
++ E ++ L++ + + E + K+ ++ ++ +++ ++K
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH 1593
Query: 980 GRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKI 1015
R V + E R ND ++ K+ +E D +++
Sbjct: 1594 TRVVETMQSTLDAEIRSR-NDALRVKKKMEGDLNEM 1628
Score = 93.2 bits (230), Expect = 1e-18
Identities = 185/939 (19%), Positives = 396/939 (42%), Gaps = 144/939 (15%)
Query: 189 EAKLKEIKTILEE------EITPTIQKLKEERSSY--------LEYQKVMREIEHLSR-- 232
EAK+KE+ EE E+T +KL++E S L KV +E +H +
Sbjct: 919 EAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE-KHATENK 977
Query: 233 -LYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKE 291
+ + ++T + ++E K +Q+ + ++L + K+ L +LE++ D +
Sbjct: 978 VKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVD-D 1036
Query: 292 TGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNM------------- 338
G L + + +R K + L +++ E+ +++L++ +
Sbjct: 1037 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISK 1096
Query: 339 VEDSKTLAAK-EKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSS----NEDG 393
+ED + + + +K++K++ + L E + + A A++ + +S L E+
Sbjct: 1097 IEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEA 1156
Query: 394 AEATLA---------GQMMACKNDISKA--QTEAKQAQMKLKHA---------------- 426
AT A + + D+ +A Q EA A ++ KHA
Sbjct: 1157 GGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRV 1216
Query: 427 QQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEK----LEAEMKKLNYEENKEESLLE-- 480
+Q+L+ +++E+K + EA+ K EK LE ++ +L +E +++ L+
Sbjct: 1217 KQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDL 1276
Query: 481 --KRRQLSRDIG---RLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDT 535
+R +L + G R + +AL+++ K + ++ L L ++T
Sbjct: 1277 TAQRARLQTEAGEYSRQLDEKDALVSQLSR--------SKQASTQQIEELKHQL--EEET 1326
Query: 536 SATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQ 595
A AL ++ + E ++ + EL+R L+K ++ T
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR-----ALSKANSEVAQWRTKYETD 1381
Query: 596 NLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGD 655
+ + + A + + LQ+A E V C +++ K +R+ L D
Sbjct: 1382 AIQRTEELEEAKKKLAQR--LQEAEEHVEAVNAKCASLEKTK-----QRLQNEVEDLMLD 1434
Query: 656 VFDPHGTLSGGARSQA--ASILTKF-QELKDVQDELRIKENELRALEEELAGLKNTAEKY 712
V + + + Q +L+++ Q+ ++ Q EL + E R+L EL +KN E
Sbjct: 1435 VERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYE-- 1492
Query: 713 RQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEK 772
E D L+T +++ Q+E+ L + I E + + ++I+++ E++
Sbjct: 1493 -----------ESLDQLETLRRENK--NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQE 1539
Query: 773 YEVLENKMKNAEAERERE---LKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEEL 829
++ ++ AEA E E + Q +L+ K++ D +K+ EK +E+ ++L
Sbjct: 1540 KCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVD---RKIAEKDEEI-------DQL 1589
Query: 830 KREHTSYKQQLEAVNEA-IKSYESQIEV---MAAEVAKNKESVNKAQEEVTKQKEVITAQ 885
KR HT + +++ +A I+S + V M ++ + + +N A +
Sbjct: 1590 KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNT 1649
Query: 886 DTVIKAK--YAEVAKHKEQNNDSQLKIKELDHNISKHKRE---AEDGAAKVSKMLKDYDW 940
++K + + A +++ QL I E N+ + + E A + S+ + + +
Sbjct: 1650 QGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL 1709
Query: 941 INAERH---LFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEER 997
++A L Q S + K + Q +++E+ ++ RN +A +T+A
Sbjct: 1710 LDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQE-SRNAEEKAKKAITDAAMM 1768
Query: 998 YNDLMKKKRI---VENDKSKILTTIEDLDQKKNQALNIA 1033
+L K++ +E K + T++DL + ++A +A
Sbjct: 1769 AEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1807
Score = 82.4 bits (202), Expect = 2e-15
Identities = 156/767 (20%), Positives = 310/767 (40%), Gaps = 108/767 (14%)
Query: 304 AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ 363
AE ++ + F K LA E+KRKELE+ MV K + +V+ D L +
Sbjct: 846 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 364 EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEAT-----LAGQMMACKNDISKAQTEAK 417
E + + + V+ E+ AE T L + K DI +
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965
Query: 418 QAQMKLKHAQQELKNKQAEVKKMD---SGYRKDQEAL-EAVKRLKEKLEAEMKKLN---- 469
+ + + + ++KN E+ +D + K+++AL E ++ + L+AE K+N
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025
Query: 470 ------YEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVK 523
+ + E LE+ ++L D+ R K E +L+ A E + K
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG------DLKLA---QESTMDMENDK 1076
Query: 524 GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISA 583
+ + K+ + + + E+ + + ++ EL+ R + ++
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIK--------ELQAR-----IEELGE 1123
Query: 584 RCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDK 643
A R D L E+ + +E G T ++ ++ F K
Sbjct: 1124 EIEAERASRAKAEKQRSD-------LSRELEEISERLEEAGGATSAQVELNKKREAEFQK 1176
Query: 644 -RIMTRTVTLGGDVF-----DPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRA 697
R TL + H Q ++ Q+L+ + EL+++ ++L +
Sbjct: 1177 LRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSS 1236
Query: 698 LEEELAGLKNTAEKY-RQLKQQ-WEMKTEE-----------ADLLQTKLQQSSYHKQQEE 744
E ++ K EK R L+ Q E+KT+E A + + + Y +Q +E
Sbjct: 1237 NAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDE 1296
Query: 745 LDALKKTIEESEE-TLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKT 803
DAL + S++ + + +E++ + EE E K KNA A L+ ++ D +
Sbjct: 1297 KDALVSQLSRSKQASTQQIEELKHQLEE-----ETKAKNALA---HALQSSRHDCDLLRE 1348
Query: 804 KADASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIKSYESQIEVMAAEVA 862
+ + + E Q+ + E+ + + ++ T Q+ E + EA K +++ E
Sbjct: 1349 QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ----EAE 1404
Query: 863 KNKESVNK--AQEEVTKQKEVITAQDTVI---KAKYAEVAKHKEQNNDSQLKIKELDHNI 917
++ E+VN A E TKQ+ +D ++ ++ A A K+Q N D +
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRN--------FDKVL 1456
Query: 918 SKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNP-KEAGQRLQKLQEMK 976
S+ K++ E+ A++ K+ ++ E FK N +E+ +L+ L+
Sbjct: 1457 SEWKQKYEETQAELEASQKESRSLSTEL-----------FKVKNVYEESLDQLETLRREN 1505
Query: 977 EKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
+ L + ++ + E ++ ++L K K+ VE +K +I +E+ +
Sbjct: 1506 KNLQQEIS-DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAE 1551
Score = 77.4 bits (189), Expect = 8e-14
Identities = 153/759 (20%), Positives = 319/759 (42%), Gaps = 118/759 (15%)
Query: 182 QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSY-LEYQKVMREIEHLSRLYIAYQFL 240
+K E ++ E+KT EEE I L +R+ E + R+++ L Q
Sbjct: 1249 EKMCRSLEDQVSELKT-KEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDAL--VSQLS 1305
Query: 241 LAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGG---ILR 297
++ + EELK ++ K + L+ +++ H+ + L ++ ++E G + R
Sbjct: 1306 RSKQASTQQIEELKHQLEEETKAKNALAH---ALQSSRHDCDLLREQYEEEQEGKAELQR 1362
Query: 298 SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRK------ELEKNMVEDSKTLAAKEKE 351
+L A +E + TK ++ D ++ EE+K+K E E+++ + A+ EK
Sbjct: 1363 ALSKANSEVAQWRTKYET--DAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKT 1420
Query: 352 VKKITDGLHALQ---EASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKN- 407
+++ + + L E SN AL Q++F+ V + + +A L ++
Sbjct: 1421 KQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSL 1480
Query: 408 --DISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEM 465
++ K + +++ +L+ ++E KN Q E+ + + + + ++++K+++E E
Sbjct: 1481 STELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEK 1540
Query: 466 KKLNYEENKEESLLE----KRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNW---N 518
++ + E+ LE K ++ ++ ++K + +A KD E + N
Sbjct: 1541 CEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE--------KDEEIDQLKRN 1592
Query: 519 RNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPL 578
V + S + + S AL + KK +E G+L I L
Sbjct: 1593 HTRVVETMQSTLDAEIRSRNDALRV-----------------KKKME-GDLNEME--IQL 1632
Query: 579 NKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKK 638
N A +A E+LR +N G L E + L A+ D ++
Sbjct: 1633 NH--ANRLAAESLRNYRNTQG--------ILKETQLHLDDALR---------GQEDLKEQ 1673
Query: 639 VAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKE------ 692
+A +R R L ++ + TL RS+ + QEL D + +++
Sbjct: 1674 LAIVER---RANLLQAEIEELWATLEQTERSRKIAE----QELLDASERVQLLHTQNTSL 1726
Query: 693 -NELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQE---ELDAL 748
N + LE +++ L++ E+ Q + E K ++A + + K+Q+ L+ +
Sbjct: 1727 INTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKA-ITDAAMMAEELKKEQDTSAHLERM 1785
Query: 749 KKTIEESEE------------TLKNTKEIQRKAEEKYEVLENKMKNAE---AERERELKD 793
KK +E++ + LK K+ +K E + LE +++N + AE + L+
Sbjct: 1786 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRK 1845
Query: 794 AQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQ 853
++++ + + K + Q V+ + +++ SYK+Q E E + S+
Sbjct: 1846 HERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVK-------SYKRQAEEAEEQSNANLSK 1898
Query: 854 IEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAK 892
+ E+ + +E + A+ +V K + T I A+
Sbjct: 1899 FRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 53.1 bits (126), Expect = 2e-06
Identities = 94/408 (23%), Positives = 174/408 (42%), Gaps = 75/408 (18%)
Query: 149 RITKVLNMKPPEILSMIEEAAGTRMYEYKKIAA-------------QKTIEKKEA--KLK 193
+I K + + EI + +EEA + +E KI +K EK E +LK
Sbjct: 1531 KIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLK 1590
Query: 194 EIKTILEEEITPTIQKLKEERSSYLEYQKVMR--------EIEHLSRL-------YIAYQ 238
T + E + T+ R+ L +K M ++ H +RL Y Q
Sbjct: 1591 RNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQ 1650
Query: 239 FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE---KRKDKETGGI 295
+L E T++ + L+ +D L+E+L+ +++ L EIEEL ++ ++
Sbjct: 1651 GILKE-TQLHLDDALRGQED----LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA 1705
Query: 296 LRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKI 355
+ L DA Q ++T++ S + KKK L + S+ + + ++++S+ A+EK K I
Sbjct: 1706 EQELLDASERVQLLHTQNTSLINTKKK-LENDVSQLQSEVEEVIQESRN--AEEKAKKAI 1762
Query: 356 TDGLHALQEASNK-DAEA-LAAAQQHFNAVSAGLSSNEDGAEA-TLAG---QMMACKNDI 409
TD +E + D A L +++ L D AE L G Q+ + +
Sbjct: 1763 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1822
Query: 410 SKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMK--K 467
+ + E + Q + A + L+ + VK++ +D++ + ++ L +KL+A++K K
Sbjct: 1823 RELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYK 1882
Query: 468 LNYEENKE--------------------------ESLLEKRRQLSRDI 489
EE +E ES + K R SR++
Sbjct: 1883 RQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1930
Score = 45.4 bits (106), Expect = 3e-04
Identities = 60/251 (23%), Positives = 114/251 (45%), Gaps = 17/251 (6%)
Query: 780 MKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQ 839
+K+AE E+E A K + KTK + + + K K+ E + +TL L+E + +
Sbjct: 843 LKSAETEKEM----ATMKEEFQKTKDELAKSEAKRKELEEKMVTL-LKEKNDLQLQVQSE 897
Query: 840 LEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYA-EVAK 898
+++ +A + E I+ AK KE +A+EE E I A+ T K K E ++
Sbjct: 898 ADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEE-----EEINAELTAKKRKLEDECSE 952
Query: 899 HKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFK 958
K+ +D +L + + + K K E+ +++ + D A+ + +
Sbjct: 953 LKKDIDDLELTLAK----VEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQ 1008
Query: 959 TNNPKEAGQ-RLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILT 1017
T + +A + ++ L + K KL + V+ ++ E + R DL + KR +E D
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRM-DLERAKRKLEGDLKLAQE 1067
Query: 1018 TIEDLDQKKNQ 1028
+ D++ K Q
Sbjct: 1068 STMDMENDKQQ 1078
Score = 44.7 bits (104), Expect = 5e-04
Identities = 57/279 (20%), Positives = 113/279 (40%), Gaps = 31/279 (11%)
Query: 160 EILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEI---TPTIQKLKEERSS 216
E L+++E A E +++ A T+E+ E K I E+E+ + +Q L + +S
Sbjct: 1672 EQLAIVERRANLLQAEIEELWA--TLEQTERSRK----IAEQELLDASERVQLLHTQNTS 1725
Query: 217 YLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRS------------AEELKEMQDKVIKLQ 264
+ +K + +S+L + ++ E AEELK+ QD L+
Sbjct: 1726 LINTKKKLEN--DVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1783
Query: 265 EELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL 324
++ +K L H ++E E+ K ++ LE + E + Q K L
Sbjct: 1784 RMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGL 1843
Query: 325 ACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS 384
E + KEL ED K + + V K+ + + + + + E A F +
Sbjct: 1844 RKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQ 1903
Query: 385 AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKL 423
L E+ A+ ++ ++K + ++++ K+
Sbjct: 1904 HELEEAEERAD--------IAESQVNKLRVKSREVHTKI 1934
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 103 bits (257), Expect = 1e-21
Identities = 206/988 (20%), Positives = 426/988 (43%), Gaps = 132/988 (13%)
Query: 147 QGRITKVLNM--KPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEA-----KLKEIKTIL 199
+G +T +++ + ++L+ ++E A K++ + EK+ + ++K+ L
Sbjct: 324 KGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTL 383
Query: 200 EEEITPTIQKL----KEERSSYLEYQKVMREIE----HLSRLYIAYQFLLAEDT---KVR 248
E+E K+ +E + +++Q+V ++E HL + + ++ T + +
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESK 443
Query: 249 SAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQR 308
+ EL +++ +L EL+E K++ EE++K+ ++ L+ L EA+R
Sbjct: 444 QSAELNKLRQDYARLVNELTEKTGKLQQ-----EEVQKKNAEQAA---TQLKVQLQEAER 495
Query: 309 VNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK----KITDGLHALQE 364
+ QS +K A E+ +++L+ V AKE EV+ K+TD L + Q+
Sbjct: 496 RWEEVQSYI---RKRTAEHEAAQQDLQSKFV-------AKENEVQSLHSKLTDTLVSKQQ 545
Query: 365 ASNKDAEALAAAQQHFNAVSAGLSSNEDGAEAT--LAGQMMACKNDISKAQTEAKQAQMK 422
+ + + + Q+ N + +D E L Q+ + I+ AQT A +
Sbjct: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA-AQTSASVLAEE 604
Query: 423 LKHAQQELKNKQAEVKKMDSGYRKD-----QEALEAVKRLKEKLEAEMKKLNYEENKEES 477
L E K+KQ + + +D +E L+ ++ + L+AE++KL N++ +
Sbjct: 605 LHKVIAE-KDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAA 663
Query: 478 LLEKRRQLSRDI----GRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS-V 532
+ ++ + + +++ E L N +K N +K V L + V
Sbjct: 664 AAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI--LNDQNKALKSEVQKLQTLV 721
Query: 533 KDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLR 592
+ +E + E+ + T ++LLE G ++ LN I R +
Sbjct: 722 SEQPNKDVVEQM--EKCIQEKDEKLKTVEELLETGLIQVATKEEELNAI--RTENSSLTK 777
Query: 593 VAQNLVGPDNVHVAL-SLVEYKPELQKAMEFVFGTTFVCDNMDNAK--KVAFDKRIMTRT 649
Q+L N V+ SLVE EL+K + G + + A+ KVA ++ +
Sbjct: 778 EVQDLKAKQNDQVSFASLVE---ELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
Query: 650 VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRA-LEEELAGLKNT 708
+ + G + ++Q SI +K QEL+++ + N ++A LEE+ L NT
Sbjct: 835 KQEIKALKEEIGNVQL-EKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANT 893
Query: 709 AEKYRQLKQQWE-MKTEEADLLQTKLQQSSYHKQQEELDALKKT-----------IEESE 756
+ + L+++ E +K ++ Q L+++S Q EEL+ + K ++E E
Sbjct: 894 GKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERE 953
Query: 757 ETLKNTKEIQRKAEEKYEVLENKMKNAE--------------------AERERELKDAQK 796
L + ++ + +++ ++ +++++ + +ERE+E+
Sbjct: 954 SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWN 1013
Query: 797 KLDCAKTKADASSKKMKEKQQEVEAITLELEELKRE---------HTSYKQQLEAVNEAI 847
+LD K + KK E+QQ+VEA+ LE +E+ ++ + SY + L +
Sbjct: 1014 ELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKA 1073
Query: 848 K------SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVI----KAKYAEVA 897
K S +++V+ ++ + E Q E K K V+ + ++ ++ E
Sbjct: 1074 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN 1133
Query: 898 KHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAER-HLFGQPNSAYD 956
K K + ++S IK++ + + ++E E ++ KD + + ER HL + A
Sbjct: 1134 KWKVKVDESHKTIKQMQSSFTSSEQELE----RLRSENKDIENLRREREHLEMELEKAEM 1189
Query: 957 FKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKIL 1016
++ E + +L E KL N E ++ DL K ++ +E +SKI+
Sbjct: 1190 ERSTYVTEVRELKAQLNETLTKLRTEQN--------ERQKVAGDLHKAQQSLELIQSKIV 1241
Query: 1017 TTIEDLDQKKNQALNIAWQKVNKDFGSI 1044
D +N ++ + K+ S+
Sbjct: 1242 KAAGDTTVIENSDVSPETESSEKETMSV 1269
Score = 88.6 bits (218), Expect = 3e-17
Identities = 183/934 (19%), Positives = 393/934 (42%), Gaps = 114/934 (12%)
Query: 160 EILSMI--EEAAGTRMYEYKKIAAQKTIEKKEAKLKE----IKTIL--EEEITPTIQKLK 211
E++ ++ ++ G + KK+ + E E K K+ +KT++ E+E + LK
Sbjct: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
Query: 212 EE---------RSSYLEYQKVMREIEHLSRLYIAY---------------QFLLAEDTKV 247
E+ +SS E ++ +++ +L A Q ++ E K
Sbjct: 310 EKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTE--KE 367
Query: 248 RSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQ 307
RS + M+D++ L++E + KI E ++++ + + + +E +A +
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQ----VREQMEAEIAHLK 423
Query: 308 RVN-----TKSQSAFDLKKKNLACEESKRKELEKNMVE-DSKTLAAKEKEVKKITDGLHA 361
+ N S + L+ K A R++ + + E KT +++EV+K
Sbjct: 424 QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN----- 478
Query: 362 LQEASNKDAEALAAAQQHFNAVSAGL---SSNEDGAEATLAGQMMACKNDISKAQTEAKQ 418
++A+ + L A++ + V + + ++ + A+ L + +A +N++ ++
Sbjct: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538
Query: 419 AQMKLKHAQQEL----KNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENK 474
+ + +Q L +++Q V K +S + Q+ LE + LK +++ ++ + +
Sbjct: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
Query: 475 EESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRN-CVKGLVASLISVK 533
E + ++ ++K+T ++L + L ++ + N N +K V L ++
Sbjct: 599 SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 658
Query: 534 DTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRV 593
+ A A EL ++ V D ++ L+ E+ + + + + E ++
Sbjct: 659 NEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-EISNKMEEFKILNDQNKALKSEVQKL 717
Query: 594 AQNLV----GPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRT 649
Q LV D V ++ K E K +E + T + A K I T
Sbjct: 718 -QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLI----QVATKEEELNAIRTEN 772
Query: 650 VTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEE----ELAGL 705
+L +V D ++ S + +ELK V E K+ +++++EE EL +
Sbjct: 773 SSLTKEVQD-----LKAKQNDQVSFASLVEELKKVIHE---KDGKIKSVEELLEAELLKV 824
Query: 706 KNTAEKYRQLKQQWEMKTEEADLLQ----------TKLQ--QSSYHKQQEELDALKKTIE 753
N + + LKQ+ + EE +Q +K+Q Q+ ++E+++ +K +E
Sbjct: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
Query: 754 ESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMK 813
E E+ L NT + + +E+ E L+ + + + LK+A + ++ + +K
Sbjct: 885 EKEKDLANTGKWLQDLQEENESLK---AHVQEVAQHNLKEAS-----SASQFEELEIVLK 936
Query: 814 EKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQE 873
EK+ E++ + L+E + + +S Q L+ V + K ++SQIE + + + S E
Sbjct: 937 EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSF-PPHE 995
Query: 874 EVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAK--- 930
E+ K VI+ ++ I + E+ K+ + K E + + EA++ K
Sbjct: 996 ELLK---VISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFP 1052
Query: 931 ---VSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRA 987
V L +W+ H F + T+ +E KL+E E + + +
Sbjct: 1053 KVSVPSNLSYGEWL----HGFEKKAKECMAGTSGSEEVKVLEHKLKEADE-MHTLLQLEC 1107
Query: 988 MNVLTEAEERYNDLMKKKRIVENDKSKILTTIED 1021
+ E L K +R VE +++K +++
Sbjct: 1108 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDE 1141
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 103 bits (256), Expect = 1e-21
Identities = 197/915 (21%), Positives = 362/915 (39%), Gaps = 157/915 (17%)
Query: 142 HFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKE--AKLKEIKTIL 199
H L +Q I + L+ K E + EA G R+ E ++++++K ++K++ A L+ + L
Sbjct: 408 HGLQLQSEINQ-LHSKLLETERQLGEAHG-RLKEQRQLSSEKLMDKEQQVADLQLKLSRL 465
Query: 200 EEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDK 259
EE++ K K S+ L++Q + +H Q L + T + L+E Q+
Sbjct: 466 EEQL-----KEKVTNSTELQHQLDKTKQQHQE------QQALQQSTTAK----LREAQND 510
Query: 260 VIKLQEELSENDKKIKALNHEIEELEKRKDKETGGIL-RSLEDALAEAQRVNTKSQSAFD 318
+ ++ ++ + D+KI+ L E +K KE +L + ED A+ Q ++
Sbjct: 511 LEQVLRQIGDKDQKIQNL-----EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 319 LKKKNLACEES-------------KRKELEKNM---VEDSKT-LAAKEKEVKKITDGLHA 361
L++KN +E K+ ++N+ V++ K L A + V + ++
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 362 LQEASNKDAEALAAAQQHFNAVSAGLSSNE---DGAEATLAGQMMACKNDISKAQTEAKQ 418
L N+ E ++ A + L S E A L + +N + Q E +
Sbjct: 626 LNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNK 685
Query: 419 AQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEE-----N 473
+L +L++KQ +++S ++ +E ++++ E+LE ++KKL + +
Sbjct: 686 ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS 745
Query: 474 KEESL--LEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLIS 531
KE++L L+++RQL+ D+ LR + + V L
Sbjct: 746 KEQALQDLQQQRQLNTDL---------------ELRATELSKQLEMEKEIVSSTRLDLQK 790
Query: 532 VKDTSATTALELVAGERLYNVVV-DTEVTGKKL-LERGELKRRY--TIIPLNKISARCIA 587
+ + +L E ++ D E ++ ++ EL R T+ L K+ +
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK---ME 847
Query: 588 PETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMT 647
E L + V V+ SL K E +K E G + D K++ ++
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEK--ENQKGKAAILDLEKTCKELKHQLQVQM 905
Query: 648 RTVTLGGDVFDPHGTLSGGARSQAASILTKFQE-LKDVQDELRIKENELRALEEELAGLK 706
A Q L QE L Q+ L+ E E + L+ + LK
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 707 NTAEKYR--------QLKQQWEMKTEEADLLQTKLQQSS----------------YHKQQ 742
++E+ + +LK KTE + LQ +L Q++ Y K Q
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ 1025
Query: 743 EELDALKKTIEESEETLKNTKEIQRKAEEKYE-------------------VLENKMKNA 783
E L+ E L T++ + EEK + E K A
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085
Query: 784 EAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITL-ELEELKREHTSYKQQLEA 842
E++ K+ Q + C + K +KEK+ E L E+EE+K ++++
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK---CRQEKEITK 1142
Query: 843 VNEAIKSY--ESQIEVMAAEVAKN------------------------------KESVNK 870
+NE +KS+ ES E+ + AK K+ V K
Sbjct: 1143 LNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKK 1202
Query: 871 AQEEVTKQ-KEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAA 929
+EE+ K+ E + IK K + KH+E ++I L+ N+ K+E +
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQR 1262
Query: 930 KVSKMLKDYDWINAE 944
+VS++ K D + E
Sbjct: 1263 RVSELEKQTDDLRGE 1277
Score = 99.8 bits (247), Expect = 1e-20
Identities = 154/768 (20%), Positives = 324/768 (42%), Gaps = 82/768 (10%)
Query: 180 AAQKTIEKKEAKLKEIKTILEEEITPTIQ-----KLKEERSSYLEYQKVMREIE---HLS 231
AAQ + E + E+ + L E Q K K E E K + + HL
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670
Query: 232 RLYIAYQFLLAEDTKVRS-----AEELKEMQDKVIKLQEELSENDKKIKALNHEIEELE- 285
A Q E K+ + +L++ Q+ +L+ L E +K +L + EELE
Sbjct: 671 TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730
Query: 286 --KRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
K+ + ++ + S E AL + Q+ + Q DL+ + A E SK+ E+EK +V ++
Sbjct: 731 QIKKLEADSLEVKASKEQALQDLQQ---QRQLNTDLELR--ATELSKQLEMEKEIVSSTR 785
Query: 344 TLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAE---ATLAG 400
+++K ++ L ++++ K E +Q F +S + T
Sbjct: 786 L------DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVT 839
Query: 401 QMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDS-GYRKDQEALEAVKRLKE 459
++ K + TE + KL LKN ++E +K + G + + K LK
Sbjct: 840 ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 460 KLEAEMKKLNYEENKEESLLEKRRQLSRDIG-RLKETYEALLARFPNLRFAYKDPEKNWN 518
+L+ +M+ E+ + + LEK ++ S + L E L+ L+ K+ ++
Sbjct: 900 QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQ--- 956
Query: 519 RNCVKGLVASLISVKDTSATTA--LELVAGERLYNVVVDTEVTGK-------KLLERGEL 569
L ++ +K +S +E + GE V+ TE+ K E
Sbjct: 957 ------LQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
Query: 570 KRRYTIIPLNKISARCIAPETLRVAQN-LVGPDNVHVAL--SLVEYKPELQKAMEFVFGT 626
K + +++ N ++ ET + Q+ G ++ +A L + +L A E
Sbjct: 1011 KEKISVLQNNYEKSQ----ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE----- 1061
Query: 627 TFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQD 686
D + N ++ +++ T TL + + + + + L+D+Q
Sbjct: 1062 ----DLISNRNQIGNQNKLIQELKTA-------KATLEQDSAKKEQQLQERCKALQDIQK 1110
Query: 687 ELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTE-EADLLQTKLQQSSYHKQQEEL 745
E +KE EL + +LA ++ K RQ K+ ++ E ++ L++ + ++ ++ L
Sbjct: 1111 EKSLKEKELVNEKSKLAEIEEI--KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL 1168
Query: 746 DALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKA 805
K ++ ++LK E +++ ++ +L++++K E E ++E + + KL +
Sbjct: 1169 IQQKLELQGKADSLKAAVEQEKRNQQ---ILKDQVKKEEEELKKEFIEKEAKLHSEIKEK 1225
Query: 806 DASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNK 865
+ KK +E + + +T+++ L + K++ ++ + E Q + + E+A +
Sbjct: 1226 EVGMKKHEENEAK---LTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE 1282
Query: 866 ESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKEL 913
+V Q+E E + I+ +V + + + +++ ++EL
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQEL 1330
Score = 85.9 bits (211), Expect = 2e-16
Identities = 167/877 (19%), Positives = 358/877 (40%), Gaps = 134/877 (15%)
Query: 185 IEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAED 244
+ +K L E E++ T +K EE S Q + + + L + + +E
Sbjct: 300 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ-KDLDCQQLQSRLSASET 358
Query: 245 TKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEEL-EKRKDKETGGILRSLEDAL 303
+ R EL E + KL+EELSE + K + L E ++L ++R++KE G+ E
Sbjct: 359 SLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQ 418
Query: 304 AEAQRVNTKSQ--SAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHA 361
++ + T+ Q A K+ K + E+ + + L+ E+++K+
Sbjct: 419 LHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478
Query: 362 LQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQM 421
LQ +K QQH + S+ + ++AQ
Sbjct: 479 LQHQLDK------TKQQHQEQQALQQSTT-----------------------AKLREAQN 509
Query: 422 KLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEK 481
L+ +++ +K +++ +++ +K +E + +++ +E L A+++ E L EK
Sbjct: 510 DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569
Query: 482 RRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTAL 541
L + +L E + N ++K ++N + + V+ A L + +D
Sbjct: 570 NHTLQEQVTQLTE-------KLKNQSESHKQAQENLH-DQVQEQKAHLRAAQD------- 614
Query: 542 ELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPD 601
R+ ++ +L E E K I + + ++ E + AQ
Sbjct: 615 ------RVLSLETSVNELNSQLNESKE-KVSQLDIQIKAKTELLLSAEAAKTAQ------ 661
Query: 602 NVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHG 661
+ +LQ +++D A+ DK+ +T D
Sbjct: 662 -----------RADLQ-------------NHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
Query: 662 TLSGGARSQAASILTKFQE----LKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ 717
SQ S L +++E L+ +EL E +++ LE + +K + E+ Q Q
Sbjct: 698 QDKQEHCSQLESHLKEYKEKYLSLEQKTEEL---EGQIKKLEADSLEVKASKEQALQDLQ 754
Query: 718 QWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
Q + +L T+ L K +E +E + +T+ +K E E ++
Sbjct: 755 QQRQLNTDLELRATE---------------LSKQLEMEKEIVSSTRLDLQKKSEALESIK 799
Query: 778 NKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
K+ E E++ +D + K + + + +++ E++ + +E E L E ++ K
Sbjct: 800 QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKESV---NKAQEEVTKQKEVITAQDTVIKAKYA 894
+L V++++K+ +S+ E E K K ++ K +E+ Q +V ++T+ + K
Sbjct: 860 DKLSKVSDSLKNSKSEFE---KENQKGKAAILDLEKTCKELKHQLQV-QMENTLKEQKEL 915
Query: 895 EVAKHKEQNNDSQLKIK---------ELDHNISKHKREAEDGAAKVSKMLKDYDWINAE- 944
+ + KE+ QLK++ + + + ++++E + ++++ + + +
Sbjct: 916 KKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 945 RHLFGQPNSAYDFKTNNPKEAGQRL----QKLQEMKEKLG--RNVNMRAMNVLTEAEE-- 996
L G+ A KT + Q+L Q+L KEK+ +N ++ + +
Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 997 --RYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALN 1031
R ++L+ ++ +++ + K+ EDL +NQ N
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN 1072
Score = 79.7 bits (195), Expect = 2e-14
Identities = 161/871 (18%), Positives = 340/871 (39%), Gaps = 116/871 (13%)
Query: 199 LEEEITP--TIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFL--LAEDTKVRSAEELK 254
L+ TP T+ E S + M+ + L+ Y+ + D+ L
Sbjct: 20 LDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLA 79
Query: 255 EMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETG----------------GILRS 298
+D V L++E+ + +K EEL+K +K G L+S
Sbjct: 80 LKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQS 139
Query: 299 LEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDG 358
LE L EAQ N + DL ++ A ++ +++ E+ A E++V ++T+
Sbjct: 140 LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEE 199
Query: 359 LHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQ 418
L NK+A + + G E + K ++ + QT
Sbjct: 200 L-------NKEATVIQDLKTEL--------LQRPGIE-----DVAVLKKELVQVQTLMDN 239
Query: 419 AQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVK----RLKEKLEAEMKKLNYEENK 474
++ + ++LK+ E KK+ S Y + + ++ + +++ +++L ++
Sbjct: 240 MTLERERESEKLKD---ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
Query: 475 EESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKD 534
L +K + L+ ++ + ++ Y L + + K+ + ++ K L + +
Sbjct: 297 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ---KDLDCQQLQSRL 353
Query: 535 TSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVA 594
+++ T+L + E + E T K E E++ +Y + + E +
Sbjct: 354 SASETSLHRIHVE----LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHG 409
Query: 595 QNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGG 654
L N + L+E + +L +A G + + K + ++++ + L
Sbjct: 410 LQLQSEIN-QLHSKLLETERQLGEA----HGRLKEQRQLSSEKLMDKEQQVADLQLKLSR 464
Query: 655 DVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEEL-AGLKNTAEKYR 713
Q +T EL+ D+ + + E +AL++ A L+
Sbjct: 465 ------------LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE 512
Query: 714 QLKQQWEMKTEEADLLQTKLQQSSYH-----KQQEELDALKKTIEESEETLKNTKEIQRK 768
Q+ +Q K ++ L+ LQ+S + K++E+L A + E L +E
Sbjct: 513 QVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT 572
Query: 769 AEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEE 828
+E+ L K+KN ++ ++ ++ K A+ ++ + V + +L E
Sbjct: 573 LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
Query: 829 LKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTV 888
K + + Q++A E + S E+ A++ + ++ A ++ ++ IT Q
Sbjct: 633 SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692
Query: 889 IKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLF 948
+ AK + +H Q + +KE +++ E+ ++ K+ D + A +
Sbjct: 693 VTAKLQDKQEHCSQ---LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE-- 747
Query: 949 GQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIV 1008
Q LQ LQ+ ++ + T+ E R +L K+ +
Sbjct: 748 ------------------QALQDLQQQRQ------------LNTDLELRATELSKQ---L 774
Query: 1009 ENDKSKILTTIEDLDQKKNQALNIAWQKVNK 1039
E +K + +T DL QKK++AL QK+ K
Sbjct: 775 EMEKEIVSSTRLDL-QKKSEALESIKQKLTK 804
Score = 77.8 bits (190), Expect = 6e-14
Identities = 178/914 (19%), Positives = 378/914 (41%), Gaps = 119/914 (13%)
Query: 192 LKEIKTILEEEITPTIQKLKEERSSYLEY--------QKVMREIEHLSRLYIAYQFLLAE 243
+K++K + E++ ++ + +S Y E QKV R E L++ Q L E
Sbjct: 154 IKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTE 213
Query: 244 DTKVRSAEELKEMQDKVIKLQEELS----ENDKKIKALNHEIEELEKR--KDKETGGILR 297
+ E++ ++ +++++Q + E +++ + L E ++L+ + + T LR
Sbjct: 214 LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR 273
Query: 298 SL-----EDALAEAQRVNTKSQSAFDLKKKNLACEESK-RKELEKNMVEDSKTLAAKEKE 351
S ++ Q + S +L +KN E+ +KE + +E+ + K
Sbjct: 274 SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK- 332
Query: 352 VKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISK 411
K I LH + L+A++ + + LS EAT K ++S+
Sbjct: 333 -KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK---GEAT-----QKLKEELSE 383
Query: 412 AQTEAKQAQMKLKHAQQELKNK-------QAEVKKMDSGYRKDQEAL-EAVKRLKEKLEA 463
+T+ + + + K QQ+ + K Q+E+ ++ S + + L EA RLKE+ +
Sbjct: 384 VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQL 443
Query: 464 EMKKLNYEENK-----------EESLLEK---RRQLSRDIGRLKETYEALLA----RFPN 505
+KL +E + EE L EK +L + + K+ ++ A
Sbjct: 444 SSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 506 LRFAYKDPEKNWNR-----NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTE--- 557
LR A D E+ + ++ L A L K+ + E E LY + E
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER---EDLYAKIQAGEGET 560
Query: 558 VTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQ 617
+L E+ + K+ + E+ + AQ +N+H + E K L+
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQS---ESHKQAQ-----ENLHDQVQ--EQKAHLR 610
Query: 618 KAMEFVFGTTFVCDNM-----DNAKKVA-FDKRIMTRT-VTLGGDVFDP--HGTLSGGAR 668
A + V + + ++ +KV+ D +I +T + L + L
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670
Query: 669 SQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADL 728
+ ++ K QEL + +L +L+ +E + L++ ++Y++ E KTEE +
Sbjct: 671 TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730
Query: 729 LQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERE 788
KL+ S + + AL ++ ++ + +++ +A E + LE + + + R
Sbjct: 731 QIKKLEADSLEVKASKEQAL----QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR- 785
Query: 789 RELKDAQKKLDCAKTKADASSKKMKEKQ---QEVEAITLELEELKREHTSYKQQLEAVNE 845
D QKK + ++ +K+ +EKQ Q+ E ++ +E K +H +++
Sbjct: 786 ---LDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS---QETKIQHEELNNRIQTTVT 839
Query: 846 AIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKH-KEQNN 904
++ + + E + E++ K+ ++K + + K ++ KA ++ K KE +
Sbjct: 840 ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH 899
Query: 905 DSQLKI-------KELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDF 957
Q+++ KEL ++ K K + +++ M + I A+ L
Sbjct: 900 QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL--IQAQNTLKQNEKEEQQL 957
Query: 958 KTN------NPKEAGQRLQKLQ-EMKEKLGRNVNM--RAMNVLTEAEERYNDLMKKKRIV 1008
+ N + ++ ++++ LQ E+K + + + + LT+A + +K ++
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVL 1017
Query: 1009 ENDKSKILTTIEDL 1022
+N+ K T + L
Sbjct: 1018 QNNYEKSQETFKQL 1031
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 103 bits (256), Expect = 1e-21
Identities = 172/905 (19%), Positives = 375/905 (41%), Gaps = 130/905 (14%)
Query: 182 QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY------QKVMREIEHLSRL-- 233
Q+ I K+ +++ +KT+ E ++ SS L+ +++ +++ L +L
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402
Query: 234 -------YIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELS----ENDKKIKALNHEIE 282
Y++ Q E + E+ E +D + L +L E+D++IK L E+
Sbjct: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462
Query: 283 ELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELE------- 335
E+ K+K +E G E++ A+ Q++ K Q+A +K+ L +S ++EL
Sbjct: 1463 EM-KQKPEEIG------EESRAK-QQIQRKLQAALISRKEALKENKSLQEELSLARGTIE 1514
Query: 336 ---KNMVEDSKTLAAKEKEVKKITDGLHALQEASNK----------DAEALAAAQQHFNA 382
K++ + ++A+ KE + L LQE +K + ++L+++ +
Sbjct: 1515 RLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKL 1574
Query: 383 VSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDS 442
GL+ +++ L ++ + K S E+ + Q K K Q+E + + + +
Sbjct: 1575 ALEGLTEDKE----KLVKEIESLK---SSKIAESTEWQEKHKELQKEYEILLQSYENVSN 1627
Query: 443 GYRKDQEALEAVKRLKEKL-------EAEMKKLNYEENKEESLLEKRRQLSRDIGRLKET 495
+ Q +EAV++ K++L EA K+ + + E +E+ ++ R + K+
Sbjct: 1628 EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQ 1687
Query: 496 YEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVD 555
L + A P + + C++ L++S S+K E L V ++
Sbjct: 1688 KILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMK-------------EELERVKME 1734
Query: 556 TEVTGKK----LLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVE 611
E KK + E+ L + ++I L + NV
Sbjct: 1735 YETLSKKFQSLMSEKDSLSEEVQDLK-HQIEGNVSKQANLEATEKHDNQTNV-------- 1785
Query: 612 YKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQA 671
++ + + G T D++ + + + + + A+S
Sbjct: 1786 ----TEEGTQSIPGETEEQDSLSMSTRPTCSESVPS-------------------AKSAN 1822
Query: 672 ASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQT 731
++ F ++ + L+ ++ L+E +AGL+ +K ++ Q E + L Q
Sbjct: 1823 PAVSKDFSSHDEINNYLQ----QIDQLKERIAGLEEEKQKNKEFSQTLENEKNTL-LSQI 1877
Query: 732 KLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAEREREL 791
+ QEE+ + ++ +E L +++ AEE+ + LE ++ N AE +
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI 1937
Query: 792 KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSY-----KQQLEAVNEA 846
+ + + A+ K + +MK ++ V + E ++L +E T K+ LE + A
Sbjct: 1938 GNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGA 1997
Query: 847 IK--SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKA-KYAEVAKHKEQN 903
K +S + + + + ++ V + Q++ + +E I+A + +KA ++ + K+
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLE 2057
Query: 904 NDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPK 963
+ + ++H + K +AE + KV L D A R L + ++N
Sbjct: 2058 ITKENLAQAVEH---RKKAQAELASFKV---LLDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 964 EAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
Q QK ++++ +L + + +E+ + L ++K +E +I T+ D
Sbjct: 2112 VKSQMKQKDEDLERRL-EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKD 2170
Query: 1024 QKKNQ 1028
++ Q
Sbjct: 2171 KEVQQ 2175
Score = 91.3 bits (225), Expect = 5e-18
Identities = 191/975 (19%), Positives = 382/975 (39%), Gaps = 158/975 (16%)
Query: 163 SMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQK 222
S++E + + E K+A + E KE +KEI+++ +I + + ++ + EY+
Sbjct: 1558 SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEI 1617
Query: 223 VMREIEHLS----RLYIAYQFLLAEDT----KVRSAE-ELKEMQDKVIKLQEELSENDKK 273
+++ E++S R+ + + E K+RS E KE + ++ + ++E+ E +K
Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK 1677
Query: 274 I----KALNHEIEELEKRKDK---------------------ETGGILRSLEDALAEAQR 308
+ K+ +I ELE+ D+ + LE E +
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737
Query: 309 VNTKSQSAFDLK----------KKNLACEESKRKELEKNMVEDSKTLAAKE--KEVKKIT 356
++ K QS K K + SK+ LE D++T +E + + T
Sbjct: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGET 1797
Query: 357 DGLHALQEASNKD-AEALAAAQQHFNAVSAGLSSNE---------DGAEATLAGQMMACK 406
+ +L ++ +E++ +A+ AVS SS++ D + +AG +
Sbjct: 1798 EEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ 1857
Query: 407 NDISKAQT---EAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEA 463
+ +QT E ++ ELK Q EV KM+ ++ QE L V +LKE E
Sbjct: 1858 KNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE 1917
Query: 464 EMKKLNYEENKEESLLEKRRQLSRDIGRLKETY-------EALLARFPNLRFAYKDPEKN 516
E +++ EE L+ + +L+ IG + E L + NL+ + E+
Sbjct: 1918 E------KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE 1971
Query: 517 WNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTII 576
+ LV V+ LE + G + K+ + K ++
Sbjct: 1972 KQQ-----LVKEKTKVESEIRKEYLEKIQGAQ------------KEPGNKSHAKELQELL 2014
Query: 577 PLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA 636
+ + + + +R + + + AL V+ E QK +E + +++
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQ--TESQKDLEIT--KENLAQAVEHR 2070
Query: 637 KK----VAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKE 692
KK +A K ++ T + V + L +S S+ ++ ++ KD E R+++
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ-KDEDLERRLEQ 2129
Query: 693 NELRALEEELAGLKNTAEKYRQLKQQ--------------WEMKTEEADLLQ-------- 730
E + L+E+ KN EK L+++ K +E LQ
Sbjct: 2130 AEEKHLKEK----KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185
Query: 731 -----TKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEA 785
TK S + +D KK + + +++ +E R E+ VL+++++
Sbjct: 2186 QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSI 2245
Query: 786 ERERELK--------DAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
E ELK D Q A+T+ K Q E + + +LEE + + S +
Sbjct: 2246 HME-ELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQ 2304
Query: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKES-------VNKAQEEVTKQKEVITAQDTVIK 890
+L + +KS + Q+ ++ + K KE + + + ++ K +T ++
Sbjct: 2305 NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364
Query: 891 AKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQ 950
A ++ E+ N + KI L K EA A + D + E L +
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISL----LSGKEEAIQVAIAELRQQHDKEIKELENLLSQE 2420
Query: 951 PNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVEN 1010
+ N K + Q ++ +K N+ +A + + +K ++N
Sbjct: 2421 EEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKA---------QLDSFVKSMSSLQN 2471
Query: 1011 DKSKILTTIEDLDQK 1025
D+ +I+ + L+++
Sbjct: 2472 DRDRIVGDYQQLEER 2486
Score = 91.3 bits (225), Expect = 5e-18
Identities = 170/870 (19%), Positives = 365/870 (41%), Gaps = 109/870 (12%)
Query: 183 KTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVMREIEHLSRLYIAYQ 238
K ++K ++L+E K L +E T ++++E YLE QK H L Q
Sbjct: 1959 KNLKKCVSELEEEKQQLVKEKTKVESEIRKE---YLEKIQGAQKEPGNKSHAKEL----Q 2011
Query: 239 FLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKD--------- 289
LL E +E+K++Q I+ QE++S ++ +KAL E + E +KD
Sbjct: 2012 ELLKE-----KQQEVKQLQKDCIRYQEKISALERTVKAL--EFVQTESQKDLEITKENLA 2064
Query: 290 ------KETGGILRS----LEDALAEAQRV---NTKSQSAFDLKKKNLACEESKRKELEK 336
K+ L S L+D +EA RV N K + K+++ + ++ E +
Sbjct: 2065 QAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 337 NMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
+E ++ KEK K + + L AL+ E + Q N + ++ ++
Sbjct: 2125 RRLEQAEEKHLKEK--KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDS 2182
Query: 397 TLAG------QMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
T+ M + ++D + EAK+ + K A Q K ++ +K+ + KDQ
Sbjct: 2183 TVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS-KEEEIRLKEDNCSVLKDQ-- 2239
Query: 451 LEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDI-GRLKETYEALLARFPNLRFA 509
L + E+L+ + +L +++ ES + QL + + L+ + LL++ R
Sbjct: 2240 LRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHL 2299
Query: 510 YKDPEKNWNRNCVKGLVASLISVKD--TSATTALELVAGER--LYNVVVDTEV---TGKK 562
Y ++N + L + L S+KD T + +LE ++ L ++ E K
Sbjct: 2300 YHS-----SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKF 2354
Query: 563 LLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK-----PELQ 617
E+ E + + +++ E ++ + + VA++ + + EL+
Sbjct: 2355 SYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE 2414
Query: 618 KAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTK 677
+ V + +N K V ++M T+ + L +S ++
Sbjct: 2415 NLLSQEEEENIVLEE-ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKS-----MSS 2468
Query: 678 FQELKD--VQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQ 735
Q +D V D +++E L + E+ ++ A + +LK++ D L +
Sbjct: 2469 LQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS---- 2524
Query: 736 SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENK-MKNAEAERERELKDA 794
+ +LDA E + K+ Q+K + ++ +NK ++N A+ E +LK++
Sbjct: 2525 -----ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKES 2579
Query: 795 QKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQI 854
++ + + +A ++ ++ +E+E++ + + +L R+ T+ +++ + Y +Q+
Sbjct: 2580 EEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE-----GTLGLYHAQL 2634
Query: 855 EVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD 914
+V EV + + +Q+ + + +E + K E+ + + ++K L
Sbjct: 2635 KVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEI------EDKLKKELKHLH 2688
Query: 915 HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQE 974
H+ + E E +V+++ +D + + + + N T + G+ + LQ
Sbjct: 2689 HDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL---TAQIQSFGRSMSSLQN 2745
Query: 975 MKEKLGRNVNMRAMNVLTEAEERYNDLMKK 1004
++ A L E + +Y+ +K+
Sbjct: 2746 SRD--------HANEELDELKRKYDASLKE 2767
Score = 89.0 bits (219), Expect = 2e-17
Identities = 187/961 (19%), Positives = 380/961 (39%), Gaps = 140/961 (14%)
Query: 172 RMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL--------EYQKV 223
+M ++ K QK +E L+E L E+ P KE + L E ++V
Sbjct: 1677 KMRKFAKSKQQKILE-----LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731
Query: 224 MREIEHLSRLYIAYQFLLAE-DTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIE 282
E E LS+ +Q L++E D+ ++LK + + Q L +K N E
Sbjct: 1732 KMEYETLSK---KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEE 1788
Query: 283 ELEK--RKDKETGGILRSLEDALAEA------------------QRVNTKSQSAFDLKKK 322
+ + +E + S +E+ +N Q LK++
Sbjct: 1789 GTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKER 1848
Query: 323 NLACEESKRK--ELEKNMVEDSKTL----AAKEKEVKKITDGLHALQEASNKDAEALAAA 376
EE K+K E + + + TL + K+ E+K + + + + + + E L+
Sbjct: 1849 IAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908
Query: 377 QQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKN---- 432
+ + +D E L Q+ I + AQ+K + + E+KN
Sbjct: 1909 TK----LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKC 1964
Query: 433 -KQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKK---LNYEENKEESLLEKR---RQL 485
+ E +K K + E K EK++ K+ ++ + +E L EK+ +QL
Sbjct: 1965 VSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024
Query: 486 SRDIGRLKETYEALLARFPNLRFAYKDPEKNW------------NRNCVKGLVASL-ISV 532
+D R +E AL L F + +K+ +R + +AS + +
Sbjct: 2025 QKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLL 2084
Query: 533 KDTSATTALELVAGERLYNVVVDTEVTGKKLLERGE--LKRRYTIIPLNKISARCIAPET 590
DT + A L +L + + + K +++ + L+RR + + E
Sbjct: 2085 DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEK 2144
Query: 591 LRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNA--KKVAFDKRIMTR 648
L + + VH+ ++ E + L K + V + +N+D+ + AF K + +
Sbjct: 2145 LDALRR----EKVHLEETIGEIQVTLNKKDKEV---QQLQENLDSTVTQLAAFTKSMSS- 2196
Query: 649 TVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNT 708
L D R + +I +K +E++ +D + +++LR + + LK
Sbjct: 2197 ---LQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKIN 2253
Query: 709 AEKYRQLKQQWEMKTEEADLLQTKL-----------------QQSSYHKQQEELDALKKT 751
+ KQ WE K + LQ K+ + YH Q EL L+
Sbjct: 2254 ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE 2313
Query: 752 IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERER---ELKDAQKKLDCAKTKADAS 808
++ ++ L + K +E+ LE ++ EA+ + + + L ++
Sbjct: 2314 LKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRL 2373
Query: 809 SKKMKEKQQEV--------EAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860
+++ K+Q++ EAI + + EL+++H ++L E + S E + ++ E
Sbjct: 2374 HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKEL----ENLLSQEEEENIVLEE 2429
Query: 861 VAKNKESVNKAQEEV----TKQKEVITAQ---DTVIKAKYA-EVAKHKEQNNDSQLKIKE 912
+NK++V+K + + T +KE I + D+ +K+ + + + + + QL+ +
Sbjct: 2430 --ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERH 2487
Query: 913 LDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE-------- 964
L + K + ++ AA+ +K+ ++ + + N+ D + +E
Sbjct: 2488 LSIILEKDQL-IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITI 2546
Query: 965 ---AGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIED 1021
++L ++Q + K N + L E+EE DL + ++ +K + IE
Sbjct: 2547 KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIES 2606
Query: 1022 L 1022
L
Sbjct: 2607 L 2607
Score = 79.3 bits (194), Expect = 2e-14
Identities = 146/746 (19%), Positives = 313/746 (41%), Gaps = 99/746 (13%)
Query: 146 MQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITP 205
+Q ++ L + E+LS +EE +Y ++Q + K E++LK +K L + ++
Sbjct: 2274 LQQKVCDTLQGENKELLSQLEETR--HLYH----SSQNELAKLESELKSLKDQLTD-LSN 2326
Query: 206 TIQKLKEERSSYLEYQKVMREIE-HLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQ 264
+++K KE++ + + ++R+ E + +Y+ L +T ++++ EL + I ++
Sbjct: 2327 SLEKCKEQKGNL---EGIIRQQEADIQNSKFSYEQL---ETDLQASRELTSRLHEEINMK 2380
Query: 265 EE--LSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKK 322
E+ +S K +A+ I EL ++ DKE ++ LE+ L++ + ++
Sbjct: 2381 EQKIISLLSGKEEAIQVAIAELRQQHDKE----IKELENLLSQEE-------------EE 2423
Query: 323 NLACEESKRKELEKN--MVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHF 380
N+ EE +K ++K ++E KT+ + + K D + D + + Q
Sbjct: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
Query: 381 NAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKM 440
+ +D I +A E + + +++ + + + +E K+
Sbjct: 2484 EERHLSIILEKDQL--------------IQEAAAENNKLKEEIRGLRSHMDDLNSENAKL 2529
Query: 441 DSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALL 500
D+ + +E L V +K+ + ++ ++ ++NKE L K +L + +E E L
Sbjct: 2530 DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKE--LENKYAKLEEKLKESEEANEDLR 2587
Query: 501 ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNV---VVDTE 557
F L+ +D K ++ L S+ + T TAL+ LY+ V + E
Sbjct: 2588 RSFNALQEEKQDLSKE-----IESLKVSISQL--TRQVTALQEEGTLGLYHAQLKVKEEE 2640
Query: 558 VTGKKLLERGELKR----RYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK 613
V L KR ++ + K +A+ + ++ + L ++H ++ +
Sbjct: 2641 VHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKEL---KHLHHDAGIMRNE 2697
Query: 614 PELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAAS 673
E + V + V + + +T + G A +
Sbjct: 2698 TETAEERVAELARDLV-EMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDE 2756
Query: 674 ILTKFQ-ELKDVQD--ELRIKENELRALEEELAGLKNTAEK-----YRQLKQQWEMKTEE 725
+ K+ LK++ E + E AL E A N+ E+ +L QQ K E+
Sbjct: 2757 LKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQ 2816
Query: 726 ADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEE-------------- 771
L ++L+ S + Q + +++ + L N E RK+EE
Sbjct: 2817 LLHLSSQLEDS--YNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPA 2874
Query: 772 KYEVLENKMKNAEAERER---ELKDAQK---KLDCAKTKADASSKKMKEKQQEVEAITLE 825
+ + L+ M + + +R+R ELK+ Q+ +++ T+ +++E Q + +A +
Sbjct: 2875 EVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIM 2934
Query: 826 LEELKREHTSYKQQLEAVNEAIKSYE 851
EEL++E+ S++ +L + S+E
Sbjct: 2935 QEELRQENLSWQHELHQLRMEKSSWE 2960
Score = 77.0 bits (188), Expect = 1e-13
Identities = 155/872 (17%), Positives = 350/872 (40%), Gaps = 126/872 (14%)
Query: 186 EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDT 245
+K E ++ +TI +++ +Q+ +E S +L + +H + ++ + E T
Sbjct: 408 DKNEQAVQSAQTI--QQLEDQLQQKSKEISQFLNRLPLQ---QHETASQTSFPDVYNEGT 462
Query: 246 KVRSAEELKEMQDKVIKLQEELSENDKKIKALNH-EIEELEKRKDKETGGI-LRSLEDAL 303
+ + E + +Q +V++L EN+K L+ E+EEL+ +K + I L ++
Sbjct: 463 QAVTEENIASLQKRVVEL-----ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
Query: 304 AEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQ 363
EA R ++ K++ + EES + LE + K L+ E+K+ + + L+
Sbjct: 518 GEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLK 577
Query: 364 -------------------EASNKDAEALAAAQQHFNAVSAG----LSSNEDGAEATLAG 400
E + E +A + G L NE+ + +
Sbjct: 578 LQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEK 637
Query: 401 QMMACKNDI-SKAQTEAKQAQMKLKHAQQ------------------ELKNKQAEVKKMD 441
+ + ++ + + A ++LK +Q EL+ ++++ +++
Sbjct: 638 EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELE 697
Query: 442 SGYRKDQEALEA--------VKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLK 493
+ K QE E + L + +E K + + +L E+R QL + L
Sbjct: 698 LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS 757
Query: 494 ETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVV 553
E L A+ L + E+ D + TA + + E+++++
Sbjct: 758 MVTE-LRAQVKQLEMNLAEAERQRRL--------------DYESQTAHDNLLTEQIHSLS 802
Query: 554 VDTEVTGKKL-LERGELKRRYTIIPLNKISARCIAPETL-RVAQNLVGPDNV-HVALSLV 610
++ + K+ + + EL R + + + ++ L G + V H++ +
Sbjct: 803 IEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVE 862
Query: 611 EYKPEL-QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVT-LGGDVFDPHGTLSGGAR 668
E L QK +E + + + + + + VT + + + L+
Sbjct: 863 ELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF 922
Query: 669 SQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKY--------RQLKQQWE 720
S I T ++L + K+ ++ E +GLK ++ +L+ +++
Sbjct: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
Query: 721 MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
+ +E + + KLQ + ++++ L + + EE L N K+ E K E+ ++
Sbjct: 983 LLKKENEQRKRKLQAALINRKE-----LLQRVSRLEEELANLKD-----ESKKEIPLSET 1032
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMK----EKQQEVEAITLELEELKREHTSY 836
+ E E ++E K+ +K C +K +K EK+ E++ I +LEE +
Sbjct: 1033 ERGEVEEDKENKEYSEK--CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQF 1090
Query: 837 KQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKE----VITAQDTVIKAK 892
+ ++ +N+ ++ +QI+++ AE+++N+ + K T + + + VI
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150
Query: 893 YAEVAKH-KEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHL---- 947
++H K + + L +++ + K +EA + K ++ ERHL
Sbjct: 1151 CTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQE-----KERHLREEL 1205
Query: 948 ------FGQPNSAYDFKTNNPKEAGQRLQKLQ 973
+ + +D ++ + G +L++LQ
Sbjct: 1206 KQQKDDYNRLQEQFDEQSKENENIGDQLRQLQ 1237
Score = 73.2 bits (178), Expect = 1e-12
Identities = 186/968 (19%), Positives = 397/968 (41%), Gaps = 146/968 (15%)
Query: 182 QKTIEKKEAKLKEI---------KTILEEEITPTIQKLKEERSSYLEYQK--VMREIEHL 230
Q+ +++K+ ++K++ K E ++ ++ E LE K + + +EH
Sbjct: 2011 QELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHR 2070
Query: 231 SRLY--IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKA-LNHEIEELEKR 287
+ +A +L +DT+ +A L + +KL++EL N + +K+ + + E+LE+R
Sbjct: 2071 KKAQAELASFKVLLDDTQSEAARVLADN----LKLKKELQSNKESVKSQMKQKDEDLERR 2126
Query: 288 KDKETGGILR---SLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKT 344
++ L+ ++++ L +R + + L ++ + ++L++N+
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 345 LAAKEKEVKKITDGL-HALQEASN---KDAEALAAAQQHFNAVSAGLSSNEDGAEATLAG 400
LAA K + + D + EA K ++A+ + ++ S +D ++
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ-MSI 2245
Query: 401 QMMACKNDISKAQTEAK----QAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKR 456
M K +IS+ + + + +AQ +++ Q+ Q E K++ S + + + +
Sbjct: 2246 HMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQN 2305
Query: 457 LKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKN 516
KLE+E+K L + + LEK ++ G L+ A N +F+Y+ E +
Sbjct: 2306 ELAKLESELKSLKDQLTDLSNSLEKCKEQK---GNLEGIIRQQEADIQNSKFSYEQLETD 2362
Query: 517 WNR------------NCVKGLVASLISVKDTSATTAL---------------ELVAGERL 549
N + + SL+S K+ + A+ L++ E
Sbjct: 2363 LQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE 2422
Query: 550 YNVVVDTEVTGKKLLER-GELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVA-- 606
N+V++ E KK +++ +L I I + ++ +L + V
Sbjct: 2423 ENIVLEEE--NKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDY 2480
Query: 607 -------LSLVEYKPEL--------QKAMEFVFGTTFVCD--NMDNAK---KVAFDKRIM 646
LS++ K +L K E + G D N +NAK ++ + +
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDL 2540
Query: 647 TRTVTLGGD----VFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEEL 702
+ +T+ + + + ++ A + K +E ++ ++LR N AL+EE
Sbjct: 2541 NQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN---ALQEEK 2597
Query: 703 AGLKNTAEKYR----QLKQQWEMKTEEADL----LQTKLQQSSYHKQQEELDALKKTIEE 754
L E + QL +Q EE L Q K+++ H+ + +K I E
Sbjct: 2598 QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAE 2657
Query: 755 SEETL--------KNTKEIQRKAEEKYE-------VLENKMKNAE---AERERELKDAQK 796
EE L K EI+ K +++ + ++ N+ + AE AE R+L + ++
Sbjct: 2658 LEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ 2717
Query: 797 KLDCAK-------TKADASSKKMKEKQQEVEAITLELEELKREH-TSYKQQLEAVNEAIK 848
KL + + + M Q + EL+ELKR++ S K+ + + +
Sbjct: 2718 KLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2777
Query: 849 SYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQL 908
+ E A +++ S+N +E E + Q + +K ++ Q DS
Sbjct: 2778 NRERD-----ALLSETAFSMNSTEENSLSHLEKLNQQ---LLSKDEQLLHLSSQLEDSYN 2829
Query: 909 KIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQR 968
+++ ++ + E + ++ K K + ++ QP+++ + + K+A
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEE---GKQRSAAQPSTS-PAEVQSLKKAMSS 2885
Query: 969 LQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTI-EDLDQKKN 1027
LQ ++ K +N+ + + + E E + +K + DK+K + E+L Q+
Sbjct: 2886 LQNDRDRLLKELKNLQQQYLQINQEITELHP--LKAQLQEYQDKTKAFQIMQEELRQE-- 2941
Query: 1028 QALNIAWQ 1035
N++WQ
Sbjct: 2942 ---NLSWQ 2946
Score = 65.1 bits (157), Expect = 4e-10
Identities = 173/921 (18%), Positives = 374/921 (40%), Gaps = 160/921 (17%)
Query: 189 EAKLKEIKT-ILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKV 247
EAK K++K +L+ E L + + + E ++R ++ Q E +
Sbjct: 804 EAKSKDVKIEVLQNE-------LDDVQLQFSEQSTLIRSLQS--------QLQNKESEVL 848
Query: 248 RSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQ 307
AE ++ + KV +L + LS+ + +I ++ + LEK++D ET L+ + E
Sbjct: 849 EGAERVRHISSKVEELSQALSQKELEITKMDQLL--LEKKRDVET------LQQTIEEKD 900
Query: 308 RVNTKSQSAFDLKKKNLACEESKRK-ELEKNMVEDSKTLAAKEKEVKKITDGLHALQEAS 366
+ T + +F + +K + E K +E +++ L ++ +E KK E
Sbjct: 901 QQVT--EISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKK---------EQV 949
Query: 367 NKDAEALAAAQQHFNAVS-AGLSSNED--------------------------------- 392
+D E + +Q+++ +S AG S E+
Sbjct: 950 EEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRV 1009
Query: 393 -GAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQE-----LKNKQAEVKKMDSGYRK 446
E LA K +I ++TE + + ++ + K ++ E+ + K
Sbjct: 1010 SRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEK 1069
Query: 447 DQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNL 506
+ E K L+EKL AE + + ++L +K Q+ + E +A++ + L
Sbjct: 1070 EVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISEN-QAIIQK---L 1125
Query: 507 RFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLER 566
+ D + VK V +IS T ++ + E++ + + E KKL E
Sbjct: 1126 ITSNTDASDGDSVALVKETV--VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA 1183
Query: 567 GELKRRYTIIPLNKISARCIAPET---------LRVAQNLVGPDNVHVALSLVEYKPELQ 617
L R I+ + R + E L+ + +N ++ L + + +++
Sbjct: 1184 --LTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241
Query: 618 KAMEFVFGTTFV---CDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASI 674
++++ +T C + ++ F T V + + + S+ AS
Sbjct: 1242 ESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQP----VLESNLCPDWPSHSEDASA 1297
Query: 675 LTKFQELKDVQDELRIKENELRALEEELAG----LKNTAEKYRQLKQQWEMKTEEADLLQ 730
L + ++ +L+ E E LE +++ L +E+ QL++Q + E + L+
Sbjct: 1298 LQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLK 1357
Query: 731 TKLQQSSYHKQQEELDALKKTIEESE---ETLKNTKEIQRKAEEKYEVLENKMKNAE--- 784
T ++ H + +L++ +E S+ L++ +E+Q K +E +++ K ++
Sbjct: 1358 TVSHEAEVHAE-----SLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLS 1412
Query: 785 ---AERERELKDAQKKL----DCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
+E+E L Q ++ D K + KE + ++ + +EL E+ K
Sbjct: 1413 GQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEM-------K 1465
Query: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVA 897
Q+ E + E ++ + + A + KE++ +E + Q+E+ A+ T+ + +
Sbjct: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEAL---KENKSLQEELSLARGTIERLTKS--- 1519
Query: 898 KHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDF 957
+ +++ +S +E + +++ + ++ D + E N +
Sbjct: 1520 ------------LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSS 1567
Query: 958 KTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVL---TEAEERYNDLMKKKRI------- 1007
+ K A L+ L E KEKL + + + + TE +E++ +L K+ I
Sbjct: 1568 SCESLKLA---LEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYEN 1624
Query: 1008 VENDKSKILTTIEDLDQKKNQ 1028
V N+ +I +E + Q+K +
Sbjct: 1625 VSNEAERIQHVVEAVRQEKQE 1645
Score = 62.0 bits (149), Expect = 3e-09
Identities = 167/915 (18%), Positives = 361/915 (39%), Gaps = 105/915 (11%)
Query: 166 EEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQK----LKEERSSY-LEY 220
EE A + K+I +T + + KE K E+ +T Q+ LK+ S +E
Sbjct: 1014 EELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVEL 1073
Query: 221 QKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHE 280
Q + +++E +Q L+ + + L++ +++ LQ E+SEN I+ L
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQMNQT-----LQDKTNQIDLLQAEISENQAIIQKL--- 1125
Query: 281 IEELEKRKDKETGGILRSLEDALAEAQRVNTKSQS-AFDLKKKNLACEESKRKELEKNMV 339
+ D G + +++ + + S+ +L++K LA E+ K ++L+K +
Sbjct: 1126 ---ITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEK-EQLQKKLQ 1181
Query: 340 EDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLA 399
E L +++ +KK + L+E + + Q+ F+ S NE+ +
Sbjct: 1182 E---ALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQS---KENENIGDQLRQ 1235
Query: 400 GQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDS-----------GYRKDQ 448
Q+ ++ K + +Q +E K E + +D
Sbjct: 1236 LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDA 1295
Query: 449 EALEA------VKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLAR 502
AL+ +K +++EAE +L + + S L K+ S ++ +L+E
Sbjct: 1296 SALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK---SEEVFQLQEQINKQGLE 1352
Query: 503 FPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKK 562
+L+ + E + S++ ++ L++ E L + + +K
Sbjct: 1353 IESLKTVSHEAEVHAE------------SLQQKLESSQLQIAGLEHLRELQPKLDEL-QK 1399
Query: 563 LLERGELKRRYTIIPLNKISARCIAPETLRVAQ-NLVGPDNVHVALSLVEYKPELQKAME 621
L+ + E Y L++ A +T + Q +L+ + + + E+ +++
Sbjct: 1400 LISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ- 1458
Query: 622 FVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTK--FQ 679
+C+ +++ + R + + QAA I K +
Sbjct: 1459 -----VELCEMKQKPEEIGEESRAKQQIQR----------------KLQAALISRKEALK 1497
Query: 680 ELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ----QWEMKTEEADLLQTKLQQ 735
E K +Q+EL + + L + LA +++ + K + + EE D L T++ +
Sbjct: 1498 ENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557
Query: 736 SSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQ 795
S Q +L + E + L+ E + K ++ E L++ E + + K+ Q
Sbjct: 1558 SLLENQ-----SLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612
Query: 796 KKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIE 855
K+ + + S + + Q VEA+ E +EL + S + + + ++ E ++E
Sbjct: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME 1672
Query: 856 VMAAEVAK----NKESVNKAQEEVTK-QKEVITAQDTV---IKAKYAEVAKHKEQNNDSQ 907
M ++ K ++ + + +EE + + EV A DT ++ + A KE+ +
Sbjct: 1673 EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK 1732
Query: 908 LKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQ 967
++ + L E +D ++ + LK N + + +D +TN +E Q
Sbjct: 1733 MEYETLSKKFQSLMSE-KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791
Query: 968 RLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKN 1027
+ E ++ L + + A+ + K + +I ++ +DQ K
Sbjct: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKD----FSSHDEINNYLQQIDQLKE 1847
Query: 1028 QALNIAWQK-VNKDF 1041
+ + +K NK+F
Sbjct: 1848 RIAGLEEEKQKNKEF 1862
Score = 61.2 bits (147), Expect = 6e-09
Identities = 139/779 (17%), Positives = 308/779 (39%), Gaps = 119/779 (15%)
Query: 180 AAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREI-EHLSRL----- 233
AAQ+ + +K+A+ + + E+E+ + + E + + + R++ EH L
Sbjct: 214 AAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ 273
Query: 234 ---YIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIE-ELEKRK- 288
+ + AE +++L++M+ + L+ + ++ K L ++E E+ +RK
Sbjct: 274 VVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKL 333
Query: 289 -----DKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSK 343
+E +L E A Q+ +L+ + A E+ + E+E E +
Sbjct: 334 SFHNLQEEMHHLLEQFEQA----------GQAQAELESRYSALEQKHKAEME----EKTS 379
Query: 344 TLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMM 403
+ + +K +++ AL++ ++K + NE ++ Q +
Sbjct: 380 HILSLQKTGQELQSACDALKDQNSKLLQ----------------DKNEQAVQSAQTIQQL 423
Query: 404 ACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRK-DQEALEAVKRLKEKLE 462
++ + + E Q +L Q E ++ + + G + +E + ++++ +LE
Sbjct: 424 --EDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELE 481
Query: 463 AEMKKLNYEENKEESLLEKRRQLSRDIGRL----------KETYEALLARFPNLRFAY-- 510
E L + E L + +LS I L +E E + N R +
Sbjct: 482 NEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE 541
Query: 511 ---KDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERG 567
+D +N K L L+ +K+ A E +A +L E ++L++
Sbjct: 542 ESGQDVLENTFSQKHKELSVLLLEMKE-----AQEEIAFLKLQLQGKRAEEADHEVLDQK 596
Query: 568 ELKRRYTIIPLNKISARCIAPETLRVAQNLVGPD-----NVHVALSLVEYKPELQKAMEF 622
E+K ++ IAP ++V G D N +L VE + Q + E
Sbjct: 597 EMK---------QMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE---QASTEH 644
Query: 623 VFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELK 682
T+ D ++ K+ ++++ D+ H +SQ + F + +
Sbjct: 645 QSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQ 704
Query: 683 DVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQ 742
+ I E L +E++ L E++++
Sbjct: 705 E------IYEKNLDEKAKEISNLNQLIEEFKK-------------------------NAD 733
Query: 743 EELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELK-DAQKKLDCA 801
A EE ++ L KE+ E + +V + +M AEAER+R L ++Q D
Sbjct: 734 NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793
Query: 802 KTKADAS-SKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAE 860
T+ S S + K K ++E + EL++++ + + + ++ +++ ES++ A
Sbjct: 794 LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853
Query: 861 VAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISK 919
V V + + +++++ IT D ++ K +V ++ + ++ E+ ++++
Sbjct: 854 VRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTE 912
Score = 56.2 bits (134), Expect = 2e-07
Identities = 172/928 (18%), Positives = 368/928 (39%), Gaps = 137/928 (14%)
Query: 182 QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLL 241
Q+TIE+K+ ++ EI + E++ +Q +E+ S +E + + ++ LSR
Sbjct: 893 QQTIEEKDQQVTEISFSMTEKM---VQLNEEKFSLGVEIKTLKEQLNLLSR--------- 940
Query: 242 AEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKA-LNHEIEELEKRKDKETGGILRSLE 300
AE+ K EE E+ + + +E+S + K L HE + L+K ++ + +L
Sbjct: 941 AEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALI 1000
Query: 301 DALAEAQRVNTKSQSAFDLK---KKNLACEESKRKELEK---NMVEDSKTLAAKEKEVKK 354
+ QRV+ + +LK KK + E++R E+E+ N K + +K +E++
Sbjct: 1001 NRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI 1060
Query: 355 ITDGLHALQEAS----NKDAEALAAAQQHFNAV------------------SAGLSSNE- 391
+ +E KD E AA++ F A+ A +S N+
Sbjct: 1061 YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQA 1120
Query: 392 -------------DGAEATLAGQMMAC---------------KNDISKAQTEAKQAQMKL 423
DG L + + + I + E +Q Q KL
Sbjct: 1121 IIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL 1180
Query: 424 -----------KHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYE- 471
K AQ++ ++ + E+K+ Y + QE + + E + ++++L +
Sbjct: 1181 QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQV 1240
Query: 472 -ENKEESLLEKRRQ--------LSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCV 522
E+ + L +Q L + + E + NL + P + + + +
Sbjct: 1241 RESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDW--PSHSEDASAL 1298
Query: 523 KGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS 582
+G S+ +K + +E E V T KK E +L+ + L S
Sbjct: 1299 QG-GTSVAQIK--AQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIES 1355
Query: 583 ARCIAPETLRVAQNL---VGPDNVHVA--LSLVEYKP---ELQKAMEFVFGTTFVCDNMD 634
+ ++ E A++L + + +A L E +P ELQK +
Sbjct: 1356 LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQL 1415
Query: 635 NAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENE 694
+ K+ A K I T + + H L A+ I EL +++ + E
Sbjct: 1416 SEKEAALTK-IQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE 1474
Query: 695 LRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEE 754
RA ++ L+ ++ ++ + EE L + +++ + K ++++ +
Sbjct: 1475 SRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT--KSLADVESQVSAQNK 1532
Query: 755 SEETLKNTKEIQRKAEEKY------EVLENKMKNAEAER-----ERELKDAQK---KLDC 800
++T+ + ++ +K +LEN+ ++ E E +D +K +++
Sbjct: 1533 EKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592
Query: 801 AKTKADASS----KKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEV 856
K+ A S +K KE Q+E E + E + E + +EAV + + ++
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652
Query: 857 MAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHN 916
A + ++ + +A++E+ + KE + K+K ++ + +E+N+ + ++ H
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMR---KFAKSKQQKILELEEENDRLRAEV----HP 1705
Query: 917 ISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMK 976
+E + + +K+ ER + F+ + E +++Q++K
Sbjct: 1706 AGDTAKECMETLLSSNASMKE----ELERVKMEYETLSKKFQ-SLMSEKDSLSEEVQDLK 1760
Query: 977 EKLGRNVNMRAMNVLTEAEERYNDLMKK 1004
++ NV+ +A TE + ++ ++
Sbjct: 1761 HQIEGNVSKQANLEATEKHDNQTNVTEE 1788
Score = 55.8 bits (133), Expect = 2e-07
Identities = 178/915 (19%), Positives = 345/915 (37%), Gaps = 190/915 (20%)
Query: 235 IAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK-----------ALNHEIEE 283
+AY L + K ++ ++Q K LQEE D KIK +LN IEE
Sbjct: 54 LAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEE 113
Query: 284 LE----------------------------------KRKDKETGGILRSLEDALAEAQRV 309
++ K K +E ++ +L+ L +AQ
Sbjct: 114 MKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQ-A 172
Query: 310 NTKSQSAFDLKKKNLACEESKRKE---------LEKNMVEDSKTLAAKEKEVKKITD-GL 359
+QS+ ++++ + ++ + KE L + E + +EK+ + T L
Sbjct: 173 EQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232
Query: 360 H---ALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEA 416
H LQ + D E QQ + L +E+ +L G+ + Q E
Sbjct: 233 HEDELLQLVTQADVE--TEMQQKLRVLQRKLEEHEE----SLVGRAQV----VDLLQQEL 282
Query: 417 KQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEM--KKLNYEENK 474
A+ + + Q+L+ +AE + + ++ E K L EK+E E+ +KL++ +
Sbjct: 283 TAAEQRNQILSQQLQQMEAEHNTLRNTVETER---EESKILLEKMELEVAERKLSFHNLQ 339
Query: 475 EE--SLLEKRRQLSRDIGRLKETYEALLARFPN---------LRFAYKDPEKNWNRNCVK 523
EE LLE+ Q + L+ Y AL + L E + +K
Sbjct: 340 EEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK 399
Query: 524 GLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLN---- 579
+ L+ K+ A + + + ++L + + + L R L++ T +
Sbjct: 400 DQNSKLLQDKNEQAVQSAQTI--QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDV 457
Query: 580 -KISARCIAPETLRVAQ-NLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAK 637
+ + E + Q +V +N AL L + E KA + N
Sbjct: 458 YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRT 517
Query: 638 KVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASIL-----TKFQELKDVQDELRIKE 692
A D+ + ++ D S A +L K +EL + E++ +
Sbjct: 518 GEA-DREVSEISIV------DIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQ 570
Query: 693 NELRALEEELAGLKNTAEKYRQLKQQWEMK---------------------------TEE 725
E+ L+ +L G K E ++ Q EMK EE
Sbjct: 571 EEIAFLKLQLQG-KRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEE 629
Query: 726 ADLLQTKLQQSSYHKQ---QEELD------ALKKTIEESEETLKNTKEIQRKAEEKYEVL 776
+ L + +Q+S Q EE+ LK T ++ +++L +I + +++ E L
Sbjct: 630 SSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERL 689
Query: 777 ENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSY 836
++++ E + + +K LD EK +E+ + +EE K+ +
Sbjct: 690 KSQILELELNFHKAQEIYEKNLD--------------EKAKEISNLNQLIEEFKKNADNN 735
Query: 837 KQQLEAVNEAIKSYESQIEVMA------AEVAKNKESVNKAQEEVTKQKEVITAQDTVIK 890
A++E SQ++ ++ A+V + + ++ +A+ + E TA D ++
Sbjct: 736 SSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLL- 794
Query: 891 AKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQ 950
EQ + ++ K D I + E +D + S+ + L
Sbjct: 795 ---------TEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE----------QSTLIRS 835
Query: 951 PNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVEN 1010
S K + E +R++ + E+L + ++ + + + T+ ++ L++KKR VE
Sbjct: 836 LQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEI-TKMDQL---LLEKKRDVET 891
Query: 1011 DKSKILTTIEDLDQK 1025
+ TIE+ DQ+
Sbjct: 892 ----LQQTIEEKDQQ 902
Score = 55.8 bits (133), Expect = 2e-07
Identities = 81/374 (21%), Positives = 161/374 (43%), Gaps = 66/374 (17%)
Query: 680 ELKDVQDELRIKENELRALEEELAGLKNTAE-KYRQLKQQWEMKTEEADLLQTKLQQSSY 738
ELKD+ +R K+ +L+ +E L + A+ K ++LK L K + +S
Sbjct: 63 ELKDI---IRQKDVQLQQKDEALQEERKAADNKIKKLK------------LHAKAKLTSL 107
Query: 739 HKQQEELDALKKTI----EESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDA 794
+K EE+ A T+ +SEE L +K + EE+ E+ K+K+ E+E +
Sbjct: 108 NKYIEEMKAQGGTVLPTEPQSEEQL--SKHDKSSTEEEMEI--EKIKHKLQEKEELISTL 163
Query: 795 QKKLDCAKTKADASSK-------KMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAI 847
Q +L A+ + A S MK++ QE E L+ + + + + V E
Sbjct: 164 QAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKD 223
Query: 848 KSYESQIEVMAAEV----------AKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVA 897
+E+Q+ + E+ + ++ + Q ++ + +E + + V+ E+
Sbjct: 224 ARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELT 283
Query: 898 KHKEQNN--DSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAY 955
+++N QL+ E +HN ++ E E +K+ +L+ + AER L S +
Sbjct: 284 AAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI--LLEKMELEVAERKL-----SFH 336
Query: 956 DFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKI 1015
+ + + + L E E+ G+ E E RY+ L +K + +K+
Sbjct: 337 NLQ--------EEMHHLLEQFEQAGQ--------AQAELESRYSALEQKHKAEMEEKTSH 380
Query: 1016 LTTIEDLDQKKNQA 1029
+ +++ Q+ A
Sbjct: 381 ILSLQKTGQELQSA 394
Score = 54.3 bits (129), Expect = 7e-07
Identities = 89/448 (19%), Positives = 179/448 (39%), Gaps = 78/448 (17%)
Query: 663 LSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQ----- 717
L+ Q A T+ +E ++ +L+ KE + L+ +L+ + + +++
Sbjct: 167 LTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARF 226
Query: 718 QWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
+ +++ E +LLQ Q + Q++L L++ +EE EE+L ++ ++L+
Sbjct: 227 ETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV-------VDLLQ 279
Query: 778 NKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYK 837
++ AE Q + ++ +L++++ EH + +
Sbjct: 280 QELTAAE--------------------------------QRNQILSQQLQQMEAEHNTLR 307
Query: 838 QQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEE---VTKQKEVITAQDTVIKAKYA 894
+E E K +E M EVA+ K S + QEE + +Q E ++++Y+
Sbjct: 308 NTVETEREESKIL---LEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYS 364
Query: 895 EV-AKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQP-N 952
+ KHK + + I L + + + + SK+L+D N + Q
Sbjct: 365 ALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDK---NEQAVQSAQTIQ 421
Query: 953 SAYDFKTNNPKEAGQRLQKLQ-EMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIV--E 1009
D KE Q L +L + E + N T+A N +KR+V E
Sbjct: 422 QLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELE 481
Query: 1010 NDKSKILTTIEDLDQKKNQALNIAWQ-----------KVNKDFGSIFSTLLPGANAMLAP 1058
N+K +L + +L++ K + ++ Q + +++ I + + A
Sbjct: 482 NEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAE 541
Query: 1059 PEGQTVLDGLEFKVALGNTWKENLTELS 1086
GQ VL+ NT+ + ELS
Sbjct: 542 ESGQDVLE---------NTFSQKHKELS 560
Score = 44.3 bits (103), Expect = 7e-04
Identities = 67/334 (20%), Positives = 139/334 (41%), Gaps = 49/334 (14%)
Query: 177 KKIAAQKTIEKKEAK-LKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI 235
++ AAQ + E + LK+ + L+ + +++LK + YL+ + + E+ L
Sbjct: 2863 QRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQ 2922
Query: 236 AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKR-------- 287
YQ + TK + +E++ + + Q EL + +++ + EI E +
Sbjct: 2923 EYQ----DKTKAFQIMQ-EELRQENLSWQHEL--HQLRMEKSSWEIHERRMKEQYLMAIS 2975
Query: 288 -KDKETG---GILRSLEDALAEAQRVNTKSQ-------SAFDLKKKNLACEESKRKELEK 336
KD++ ++R L + ++ Q + + Q SA +NL E EL +
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYE----TELLR 3031
Query: 337 NMVEDS-KTLAAKEKEVKKITDGLHALQEASN-------KDAEALAAAQQHFNAVSAGLS 388
+ DS K + KE ++++ L E N +++L QQH+ + +
Sbjct: 3032 TQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCA 3091
Query: 389 SNEDGAEATLAGQMMAC--------KNDISKAQ--TEAKQAQMKLKHAQQELKNKQAEVK 438
E + AG + KN + + E ++ Q AQQ+L N + EV
Sbjct: 3092 VLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVN 3151
Query: 439 KMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEE 472
++ ++++ A + E ++++L + E
Sbjct: 3152 ELRKLLEEERDQRVAAENALSVAEEQIRRLEHSE 3185
Score = 37.0 bits (84), Expect = 0.11
Identities = 62/293 (21%), Positives = 132/293 (45%), Gaps = 23/293 (7%)
Query: 734 QQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKD 793
Q+S + +++ + +E+ + K+I R+ + ++ + K+ + ER+ D
Sbjct: 36 QESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKD-----VQLQQKDEALQEERKAAD 90
Query: 794 AQ-KKLDC-AKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYE 851
+ KKL AK K + +K ++E + + + L E S ++QL +++ E
Sbjct: 91 NKIKKLKLHAKAKLTSLNKYIEEMKAQGGTV------LPTEPQS-EEQLSKHDKSSTEEE 143
Query: 852 SQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIK 911
+IE + ++ + +E ++ Q ++T+ + AQ + + E K+Q + + I
Sbjct: 144 MEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSS---TEMEEFVMMKQQLQEKEEFIS 200
Query: 912 ELDHNISKHKREAEDGAAKV--SKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRL 969
L +S + +AE A +V K + + Q + D +T ++
Sbjct: 201 TLQAQLS--QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQ 258
Query: 970 QKLQEMKEKL-GR-NVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIE 1020
+KL+E +E L GR V LT AE+R L ++ + +E + + + T+E
Sbjct: 259 RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVE 311
Score = 32.7 bits (73), Expect = 2.1
Identities = 55/269 (20%), Positives = 109/269 (40%), Gaps = 44/269 (16%)
Query: 674 ILTKFQELKDVQDELRIKENELRALEEELAGLKNTA-------EKYRQLKQQWEMKTEEA 726
+L+K ++L + +L N++++ + +A L+N EK+R K+EE
Sbjct: 2810 LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR--------KSEEG 2861
Query: 727 DLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAE 786
+S + Q A+ + + LK K +Q ++Y + ++
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQ----QQYLQINQEI------ 2911
Query: 787 RERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNE- 845
EL + +L + K A +E +QE + EL +L+ E +S++ + E
Sbjct: 2912 --TELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQ 2969
Query: 846 ---AIKSYESQIEVMAAEVAKNKESVN-----KAQEEVTKQKEVITAQDTVIKAKYAEVA 897
AI + Q+ + + + + S + K Q + E + D Y E
Sbjct: 2970 YLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVY-ETE 3028
Query: 898 KHKEQNNDS-------QLKIKELDHNISK 919
+ Q NDS +L+I++L+ N S+
Sbjct: 3029 LLRTQLNDSLKEIHQKELRIQQLNSNFSQ 3057
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 102 bits (255), Expect = 2e-21
Identities = 189/959 (19%), Positives = 396/959 (41%), Gaps = 130/959 (13%)
Query: 150 ITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQK 209
+T+ L+ K I + EE YE K +K +EK + K KE++ L++++ K
Sbjct: 927 LTQKLSAKEDSIHILNEE------YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK 980
Query: 210 LKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSE 269
LK+E + E+ + + A +A+ ++ + ++ + E L+E
Sbjct: 981 LKKE------LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 270 NDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL--ACE 327
++ LN I EK+ +++ + E L E K Q +LK+K L CE
Sbjct: 1035 VHRR--ELNDVISIWEKKLNQQAEELQEIHEIQLQE------KEQEVAELKQKILLFGCE 1086
Query: 328 -ESKRKE---LEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAV 383
E KE L++ V+ TL ++++K+ + +++L + K L + N
Sbjct: 1087 KEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK- 1145
Query: 384 SAGLSSNEDGAEATLAGQMMA--CKNDISKAQTEAKQAQMKLKH--AQQELKNKQAEVKK 439
L N E + +M+A K +S+ ++ K + + + E NK E K
Sbjct: 1146 --SLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
Query: 440 MDSGYRKDQEALE---AVKRLKEKLEAEMKKL-NYEENKEESLLEKRRQLSRDIGRLKET 495
++ ++ A++ K+ + LEA+ +L N +K ++L + ++KE
Sbjct: 1204 LEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEA 1263
Query: 496 Y----------EALLARFP------NLRFAYKDPEKNWNRNCVKGLVA---SLISVKDT- 535
EA L + N+ F + N +K + A SL++ K+
Sbjct: 1264 LLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL 1323
Query: 536 ---------------SATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNK 580
S T L+ E + V + E +K +E L ++ T + +
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ- 1382
Query: 581 ISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVA 640
QN + A+S + + + +K C+ +D + ++
Sbjct: 1383 -------------LQNSISLSEKEAAISSLRKQYDEEK-----------CELLDQVQDLS 1418
Query: 641 FDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQE-LKDVQDELRIKENELRALE 699
F +++ + D + +A S T+ Q +K++Q +L +K E +
Sbjct: 1419 FKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD 1478
Query: 700 EELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETL 759
E++ LK E+ Q ++++ E + ++K+++ + + E + +E +
Sbjct: 1479 EQINLLK---EELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 760 KNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEV 819
+ T EI E L +KN +++ E K+ +KL + + ++KE ++++
Sbjct: 1536 QKTIEI--------ESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI 1587
Query: 820 EAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVM-----AAEVAKNKESVNKAQEE 874
+ ++ +K E + K++LE VN ++KS E +++ + + AK E KA+++
Sbjct: 1588 LTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQK 1647
Query: 875 VTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAK---- 930
+ K+ + +Q + +Y + + +++L+ +E + +I + K ++ + +
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707
Query: 931 VSKMLKDYDWINAERHLFGQ--PNSAYDFKTN----NPKEAGQRLQKL-QEMKEKLGRNV 983
V + K+ + Q Y+ K + N E + LQ++ QE +E + +
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
Query: 984 NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFG 1042
MR + +ER L + D+S I E+L++K + I Q V K+ G
Sbjct: 1768 EMRC-----QYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGG 1821
Score = 89.7 bits (221), Expect = 1e-17
Identities = 187/946 (19%), Positives = 374/946 (39%), Gaps = 166/946 (17%)
Query: 196 KTILEEEITPTIQKLKEERSSYL-EYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELK 254
K L+E++ +Q+L++ + ++ E K++ ++ L L +D + AE +
Sbjct: 316 KEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQ----LEQDKGMVIAETKR 371
Query: 255 EMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNT--- 311
+M + + +EE+++ +IK + + EEL ++K+K LE AL+ AQ+
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 312 KSQSAFDLKKKNL------------------------ACEESKRKELEKNMVEDSKTLAA 347
K ++ D + K + ++S +++ K K LA
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR 491
Query: 348 KEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKN 407
KE+E+ K LQ + E + A + + +S ++ E+ ++ K
Sbjct: 492 KEQELTK------KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKK 545
Query: 408 DISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKD-QEALEAVKRLKEKLEAEMK 466
I +++ KL+ QQE + + + +++S K QE K L LEAE
Sbjct: 546 AI------LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 467 KLNYEENKEESLLEKRRQLSRDIGRLKETYEALLA-RFPNLRFAYKDPEKNWNRNCVKGL 525
K NKE +++ ++ + ++ LK +AL + L+ Y+ + C +
Sbjct: 600 K----HNKEITVMVEKHKT--ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEK 653
Query: 526 VASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKIS--- 582
L KD + E +K LE+ ++K+ +++S
Sbjct: 654 ETLL---KDKEIIFQAHI-------------EEMNEKTLEKLDVKQTELESLSSELSEVL 697
Query: 583 -ARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAF 641
AR E L V ++ + + E K Q+ ++ + V ++ +K
Sbjct: 698 KARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEV--SIQRTEKALK 755
Query: 642 D----------------KRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDV- 684
D K L D+ G L QA++ L FQ +
Sbjct: 756 DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQ-----QASAKLDVFQSYQSAT 810
Query: 685 QDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEE 744
++ + E +L L+++L L+ E+ KQ E++ ++ D+ E
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLET--ERILLTKQVAEVEAQKKDVCT-------------E 855
Query: 745 LDALKKTIEESEETL-KNTKEIQRKAEEKYEVLENKMKNAEAERER-------------E 790
LDA K +++ + L K E+++K + +V E+K+++ E+E+ +
Sbjct: 856 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
Query: 791 LKDAQKK---------------LDCAKTKADASSKKMKEKQQEVEAITLELEE-----LK 830
+++ QKK + + + K ++K ++V+ E++E L
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
Query: 831 REHTSYKQQLEAVNEAIKSYESQIEVMAAEVAK-NKESVNKAQEEV-TKQKEVITAQDTV 888
+ K++LE + E Q E+A+ N ++ A + T QKE I + V
Sbjct: 976 DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035
Query: 889 IKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAK---------VSKMLKDYD 939
+ + +V E+ + Q + + H I ++E E K +M K+
Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEIT 1095
Query: 940 WINAE----RHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAE 995
W+ E + K+ + Q KL+ EKL ++N +++ T +
Sbjct: 1096 WLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN-KSLKENTFLQ 1154
Query: 996 ERYNDLMKKKRIVENDKSKI--LTTIEDLDQKKNQALNIAWQKVNK 1039
E+ L++ K + E DK K+ LT+ ++ Q+L + +K NK
Sbjct: 1155 EQ---LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
Score = 89.0 bits (219), Expect = 2e-17
Identities = 167/842 (19%), Positives = 339/842 (40%), Gaps = 129/842 (15%)
Query: 184 TIEKKEAKLKEIKTILEEEITPTIQKLKEE--RSSYLEYQKV--MREIEHLSRLYIAYQF 239
++ +KEA + ++ +EE + ++++ + L +K+ + +++ S + ++
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK- 1446
Query: 240 LLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSL 299
A+ + +KE+Q ++ +E E D++I L E+++ KR D G +
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKG----EM 1502
Query: 300 EDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGL 359
ED +S + K+ NL E++ K ++E + K E++ + + L
Sbjct: 1503 ED-----------DKSKMEKKESNL---ETELKSQTARIMELEDHITQKTIEIESLNEVL 1548
Query: 360 HALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQA 419
+ + + + L QHF L +D +++ +N + + E +
Sbjct: 1549 KNYNQQKDIEHKELVQKLQHFQE----LGEEKDNRVKEAEEKILTLENQVYSMKAELETK 1604
Query: 420 QMKLKHAQQELKNKQAEVKKMDSGYRKDQEA-LEAVKRLKEKLEAEMKK--LNYEENKEE 476
+ +L+H +K+K+ E+K ++ + A L +KR E+ A +KK L+ E KEE
Sbjct: 1605 KKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEE 1664
Query: 477 S-----------LLEKRRQLSRDIGRLKETYEA---------LLARFPNLRFAYKDPEKN 516
L K ++ R++ L+E ++ ++ R AY + E+
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEA 1724
Query: 517 WNRNCVKGLVASLISVKDTSATTA---LELVAGERLYNVVVDTEVTGKKL-----LERGE 568
++ CV+ ISV + T L+ V E+ V E+ + LE E
Sbjct: 1725 DSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAE 1784
Query: 569 LKRRYTIIPLNKISARCIAPE---TLRVAQNLV---GPDNVHVALSLVEYKPELQKAMEF 622
K+ + + +L VAQ++ G +N+ +L ++QK ++
Sbjct: 1785 AKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQ- 1843
Query: 623 VFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELK 682
C ++ K + + V R + + +K+++L+
Sbjct: 1844 --EKELTCQILEQKIKELDSCLVRQKEVH----------------RVEMEELTSKYEKLQ 1885
Query: 683 DVQD-ELRIKENELRALEEELAGLKNTAEKYR----QLKQQWEMKTEEADLLQTKLQQSS 737
+Q + R K EL LEE NT EK + Q K M+ + DL + KL +
Sbjct: 1886 ALQQMDGRNKPTEL--LEE------NTEEKSKSHLVQPKLLSNMEAQHNDL-EFKLAGAE 1936
Query: 738 YHKQ---------QEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERE 788
KQ Q++L L+K ++ E LK KE ++ EEK ++ + ++ E +
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQELEILK--KEYDQEREEK---IKQEQEDLELKHN 1991
Query: 789 RELKDAQKKLDCA----KTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVN 844
LK ++ + + + + + K+ K QEVEA LE + E N
Sbjct: 1992 STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQ------------EETN 2039
Query: 845 EAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNN 904
+ +K + + + + +E ++ +EE+T + + Q ++ KY + + +E
Sbjct: 2040 QLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPG 2099
Query: 905 DSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKE 964
+ + I EL +++ D K + + N E L + Y P +
Sbjct: 2100 NDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIH--NLEDRLKKYEKNVYATTVGTPYK 2157
Query: 965 AG 966
G
Sbjct: 2158 GG 2159
Score = 85.5 bits (210), Expect = 3e-16
Identities = 186/933 (19%), Positives = 393/933 (42%), Gaps = 126/933 (13%)
Query: 152 KVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLK 211
K + + E+ E++ E +K A T +K E +++K ++E+I TI+K
Sbjct: 392 KQMTTQGEELREQKEKSERAAFEELEK--ALSTAQKTEEARRKLKAEMDEQI-KTIEKTS 448
Query: 212 EERSSYLEY------QKVMREIEHLSRLYIAYQFLLAEDTKVRSAEEL-KEMQDKVIKLQ 264
EE L+ Q+V+ ++ S IA L E R +EL K++Q + + Q
Sbjct: 449 EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQ 508
Query: 265 EELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNL 324
E++ K+ + E L+ ++KE L +LE+ + + + T+S++ ++
Sbjct: 509 EQM-----KVALEKSQSEYLKISQEKEQQESL-ALEELELQKKAILTESENKLRDLQQEA 562
Query: 325 ACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS 384
++ ELE ++ K+L + + K + L A + NK E ++H
Sbjct: 563 ETYRTRILELESSL---EKSLQENKNQSKDLAVHLEAEKNKHNK--EITVMVEKH----K 613
Query: 385 AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQE-LKNK----QAEVKK 439
L S + +A ++ K + QTE ++ + K + ++ LK+K QA +++
Sbjct: 614 TELESLKHQQDALWTEKLQVLK---QQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670
Query: 440 MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEAL 499
M+ ++ EKL+ + +L ++ +L+ R +L ++ LK+ + +
Sbjct: 671 MN-------------EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKM 717
Query: 500 LARFPNLRFAYKDPEKNWNRNCVKGLVAS-LISVKDTSAT-----TALELVAGERLYNV- 552
A D +KN ++ V ++ +S++ T LEL+ ER ++
Sbjct: 718 KQELE----AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLK 773
Query: 553 -----VVDTEVTGKKLLERGELKRRYTIIPL-------NKISARCIAPETLRVAQNLVGP 600
V + E K+ GEL++ + + + + ++ Q L+
Sbjct: 774 EHQAHVENLEADIKR--SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDL 831
Query: 601 DNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPH 660
+ + L+ + E QK VC +D K D +M + ++
Sbjct: 832 ETERILLTKQVAEVEAQK--------KDVCTELDAHKIQVQD--LMQQLEKQNSEMEQKV 881
Query: 661 GTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWE 720
+L+ S+ + ++ K + E KEN + + E G K E L Q+
Sbjct: 882 KSLTQVYESKLEDGNKEQEQTKQILVE---KENMILQMRE---GQKKEIE---ILTQKLS 932
Query: 721 MKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM 780
K + +L + ++ + Q+++++ +K+ +E +ETLK K + ++A+ K E+ +
Sbjct: 933 AKEDSIHILNEE-YETKFKNQEKKMEKVKQKAKEMQETLKK-KLLDQEAKLKKELENTAL 990
Query: 781 KNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAIT-LELEELKREHTSYKQQ 839
+ ++ E++ K + + +DA S+ +++++E++T + EL + ++++
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKK 1050
Query: 840 LEAVNEAIKS-YESQIEVMAAEVAKNKESV-------NKAQEEVTKQKEVITAQDTVIKA 891
L E ++ +E Q++ EVA+ K+ + + +E+T KE QDT +
Sbjct: 1051 LNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN- 1109
Query: 892 KYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAE----RHL 947
+ +EQ + L + +K K E ++K LK+ ++ + + L
Sbjct: 1110 ------ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163
Query: 948 FGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEER--YNDLMKKK 1005
+ T+ K + Q L+ EK +++ +++ +EE D+ KK
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK 1223
Query: 1006 RIVENDKSKILTTIEDLDQKKNQALNIAWQKVN 1038
T L+ K N+ +NI+ K N
Sbjct: 1224 ------------TEALLEAKTNELINISSSKTN 1244
Score = 78.2 bits (191), Expect = 4e-14
Identities = 170/870 (19%), Positives = 344/870 (39%), Gaps = 136/870 (15%)
Query: 207 IQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDK----VIK 262
IQ+L+ S Y+ S L AYQ L E K++ L + QDK + +
Sbjct: 140 IQRLRRMERSLSSYRG------KYSELVTAYQMLQREKKKLQGI--LSQSQDKSLRRIAE 191
Query: 263 LQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKK 322
L+EEL + + K L E + + KD+ +L++ L QR+ + LK
Sbjct: 192 LREELQMDQQAKKHLQEEFDASLEEKDQYIS-VLQTQVSLLK--QRLRNGPMNVDVLKPL 248
Query: 323 NLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNA 382
+++ E+N D + + VK L LQ+ + L ++
Sbjct: 249 PQLEPQAEVFTKEENPESDGEPVVEDGTSVKT----LETLQQRVKRQENLLKRCKE---- 300
Query: 383 VSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDS 442
T+ C S+ + +Q +L+ ++ AE K+ +
Sbjct: 301 --------------TIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLIT 346
Query: 443 GYRKDQEALEAVKRLKEKLEAEMKKLNYE--ENKEESLLEKRRQLSRDIGRLKETYEALL 500
R + +E +++ K + AE K+ +E E KEE + + R ++ + + +E E
Sbjct: 347 QLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ-- 404
Query: 501 ARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTG 560
+ + R A+++ EK + + + +E + E ++ +
Sbjct: 405 -KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK 463
Query: 561 KKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAM 620
+++++ + I L K+ + +A + + + L + E++ +++ A+
Sbjct: 464 QEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER--------EFQEQMKVAL 515
Query: 621 EFVFGTTF-VCDNMDNAKKVAFD------KRIMTRTVTLGGDVFDPHGTLSGGARSQAAS 673
E + + + +A + K I+T + D+ + +A +
Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDL-----------QQEAET 564
Query: 674 ILTKFQELKD-VQDELRIKENELRALEEELAGLKNTAEK-----YRQLKQQWEMKTEEAD 727
T+ EL+ ++ L+ +N+ + L L KN K + K + E + D
Sbjct: 565 YRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQD 624
Query: 728 LLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAER 787
L T+ Q + Q E++ L++ E+ +ETL KEI +A + E
Sbjct: 625 ALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA------------HIEEMN 672
Query: 788 ERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAI 847
E+ L+ KLD +T+ ++ S ++ E + + EL LK + KQ+LE
Sbjct: 673 EKTLE----KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE------ 722
Query: 848 KSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKH----KEQN 903
AK E N Q++V D++IK + + K+Q
Sbjct: 723 --------------AKMDEQKNHHQQQV----------DSIIKEHEVSIQRTEKALKDQI 758
Query: 904 NDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPK 963
N +L +KE D ++ +H+ E+ A + + + +A+ +F +Y T+
Sbjct: 759 NQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVF----QSYQSATHEQT 814
Query: 964 EAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLD 1023
+A + ++L ++++KL +++ +L + + KK E D KI ++DL
Sbjct: 815 KAYE--EQLAQLQQKL---LDLETERILLTKQVAEVEAQKKDVCTELDAHKI--QVQDLM 867
Query: 1024 QKKNQALNIAWQKVNKDFGSIFSTLLPGAN 1053
Q+ + + QKV K ++ + L N
Sbjct: 868 QQLEKQNSEMEQKV-KSLTQVYESKLEDGN 896
Score = 61.6 bits (148), Expect = 4e-09
Identities = 83/329 (25%), Positives = 142/329 (43%), Gaps = 55/329 (16%)
Query: 182 QKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLE----YQKVMREIEHLSRLYIAY 237
QKT E+K + L+ T E+ + Q+ +E SS+ E YQ+ + ++EH
Sbjct: 1731 QKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEH-------- 1782
Query: 238 QFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILR 297
+ + E Q + LQEEL E +KK + + +EK K +
Sbjct: 1783 -----------AEAKQHEDQSMIGHLQEELEEKNKKYSLI--VAQHVEKEGGKNNIQAKQ 1829
Query: 298 SLEDALAEAQRVNTKSQSAFDLKKKNLACE--ESKRKELEKNMVEDSKTLAAKEKEVKKI 355
+LE+ + Q+ L++K L C+ E K KEL+ +V + + +E+
Sbjct: 1830 NLENVFDDVQKT---------LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK 1880
Query: 356 TDGLHALQ--EASNKDAEAL---AAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDIS 410
+ L ALQ + NK E L + + V L SN + L ++ + +
Sbjct: 1881 YEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQ 1940
Query: 411 KAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLE----AEMK 466
K E + Q L+ ++E + + +KK DQE E +K+ +E LE + +K
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQQELEILKK-----EYDQEREEKIKQEQEDLELKHNSTLK 1995
Query: 467 KLNYEENKEESLLEKRRQLSRDIGRLKET 495
+L E N + L +K ++L I KET
Sbjct: 1996 QLMREFNTQ--LAQKEQELEMTI---KET 2019
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,071,307
Number of Sequences: 37866
Number of extensions: 1695530
Number of successful extensions: 29146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 518
Number of HSP's successfully gapped in prelim test: 1363
Number of HSP's that attempted gapping in prelim test: 9107
Number of HSP's gapped (non-prelim): 10398
length of query: 1197
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1083
effective length of database: 13,930,794
effective search space: 15087049902
effective search space used: 15087049902
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.