Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 110346445
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110346445 FERM and PDZ domain containing 2 like 1 isoform 4
[Homo sapiens]
(320 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110346445 FERM and PDZ domain containing 2 like 1 isoform 4 [... 650 0.0
gi|110346449 FERM and PDZ domain containing 2 like 2 isoform 4 [... 650 0.0
gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo sa... 647 0.0
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 632 0.0
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 632 0.0
gi|110346443 FERM and PDZ domain containing 2 like 1 isoform 2 [... 531 e-151
gi|110346447 FERM and PDZ domain containing 2 like 2 isoform 2 [... 531 e-151
gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo sap... 530 e-151
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 155 5e-38
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 155 5e-38
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 155 5e-38
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 155 5e-38
gi|148746189 multiple PDZ domain protein [Homo sapiens] 63 3e-10
gi|112382257 InaD-like [Homo sapiens] 61 1e-09
gi|87196343 PDZ domain containing 2 [Homo sapiens] 60 2e-09
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 59 6e-09
gi|45827729 scribble isoform b [Homo sapiens] 59 6e-09
gi|45827731 scribble isoform a [Homo sapiens] 59 6e-09
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 58 1e-08
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 58 1e-08
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 55 6e-08
gi|4759306 lin-7 homolog A [Homo sapiens] 54 1e-07
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 54 2e-07
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 54 2e-07
gi|8922944 lin-7 homolog C [Homo sapiens] 54 2e-07
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] 53 3e-07
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 53 4e-07
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 53 4e-07
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 52 5e-07
gi|11545920 lin-7 homolog B [Homo sapiens] 52 5e-07
>gi|110346445 FERM and PDZ domain containing 2 like 1 isoform 4
[Homo sapiens]
Length = 320
Score = 650 bits (1677), Expect = 0.0
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1 MTSIPFPGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSM 60
MTSIPFPGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSM
Sbjct: 1 MTSIPFPGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSM 60
Query: 61 GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 120
GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV
Sbjct: 61 GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 120
Query: 121 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG 180
RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG
Sbjct: 121 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG 180
Query: 181 ALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ 240
ALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ
Sbjct: 181 ALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ 240
Query: 241 KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI 300
KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI
Sbjct: 241 KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI 300
Query: 301 MRLGRYSFSSPLTRLSTDIF 320
MRLGRYSFSSPLTRLSTDIF
Sbjct: 301 MRLGRYSFSSPLTRLSTDIF 320
>gi|110346449 FERM and PDZ domain containing 2 like 2 isoform 4
[Homo sapiens]
Length = 320
Score = 650 bits (1677), Expect = 0.0
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1 MTSIPFPGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSM 60
MTSIPFPGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSM
Sbjct: 1 MTSIPFPGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSM 60
Query: 61 GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 120
GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV
Sbjct: 61 GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 120
Query: 121 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG 180
RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG
Sbjct: 121 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG 180
Query: 181 ALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ 240
ALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ
Sbjct: 181 ALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ 240
Query: 241 KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI 300
KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI
Sbjct: 241 KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI 300
Query: 301 MRLGRYSFSSPLTRLSTDIF 320
MRLGRYSFSSPLTRLSTDIF
Sbjct: 301 MRLGRYSFSSPLTRLSTDIF 320
>gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo
sapiens]
Length = 320
Score = 647 bits (1668), Expect = 0.0
Identities = 318/320 (99%), Positives = 319/320 (99%)
Query: 1 MTSIPFPGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSM 60
MTSIPFPGDRLLQVDGVILCGLTHKQAVQCL GPGQVARLVLERRVPRSTQQCPSANDSM
Sbjct: 1 MTSIPFPGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSM 60
Query: 61 GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 120
GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV
Sbjct: 61 GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLV 120
Query: 121 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG 180
RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG
Sbjct: 121 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG 180
Query: 181 ALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ 240
ALPE+EQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ
Sbjct: 181 ALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQ 240
Query: 241 KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI 300
KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI
Sbjct: 241 KAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDI 300
Query: 301 MRLGRYSFSSPLTRLSTDIF 320
MRLGRYSFSSPLTRLSTDIF
Sbjct: 301 MRLGRYSFSSPLTRLSTDIF 320
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 632 bits (1630), Expect = 0.0
Identities = 311/313 (99%), Positives = 312/313 (99%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GDRLLQVDGVILCGLTHKQAVQCL GPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV
Sbjct: 975 GDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 1034
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP
Sbjct: 1035 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 1094
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQ 187
GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPE+EQ
Sbjct: 1095 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQ 1154
Query: 188 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 247
EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ
Sbjct: 1155 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 1214
Query: 248 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 307
WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS
Sbjct: 1215 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 1274
Query: 308 FSSPLTRLSTDIF 320
FSSPLTRLSTDIF
Sbjct: 1275 FSSPLTRLSTDIF 1287
Score = 42.4 bits (98), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 73 LPGRPSSCV----SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 128
L G SSC ++ G + V+L K LGFS S + + +K + PG
Sbjct: 907 LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY---GGIYVKSIVPG 963
Query: 129 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
PA + G I GD +L V+G GL ++ + L G Q L+L R P
Sbjct: 964 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1014
Score = 41.6 bits (96), Expect = 0.001
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
V LK++ + GF FV E E + I + PG PAE+ I G ILA+N S
Sbjct: 754 VTLKRDPHR-GFGFVINEGEYSGQADPGIF-ISSIIPGGPAEKAKTIKPGGQILALNHIS 811
Query: 151 TEGLIFQEVLHLLRGAPQEVTLLL 174
EG F + +++ +P + L++
Sbjct: 812 LEGFTFNMAVRMIQNSPDNIELII 835
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 632 bits (1630), Expect = 0.0
Identities = 311/313 (99%), Positives = 312/313 (99%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GDRLLQVDGVILCGLTHKQAVQCL GPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV
Sbjct: 997 GDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 1056
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP
Sbjct: 1057 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 1116
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQ 187
GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPE+EQ
Sbjct: 1117 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQ 1176
Query: 188 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 247
EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ
Sbjct: 1177 EWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQ 1236
Query: 248 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 307
WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS
Sbjct: 1237 WGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYS 1296
Query: 308 FSSPLTRLSTDIF 320
FSSPLTRLSTDIF
Sbjct: 1297 FSSPLTRLSTDIF 1309
Score = 42.4 bits (98), Expect = 6e-04
Identities = 35/111 (31%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 73 LPGRPSSCV----SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPG 128
L G SSC ++ G + V+L K LGFS S + + +K + PG
Sbjct: 929 LKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY---GGIYVKSIVPG 985
Query: 129 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
PA + G I GD +L V+G GL ++ + L G Q L+L R P
Sbjct: 986 GPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVP 1036
Score = 41.6 bits (96), Expect = 0.001
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
V LK++ + GF FV E E + I + PG PAE+ I G ILA+N S
Sbjct: 776 VTLKRDPHR-GFGFVINEGEYSGQADPGIF-ISSIIPGGPAEKAKTIKPGGQILALNHIS 833
Query: 151 TEGLIFQEVLHLLRGAPQEVTLLL 174
EG F + +++ +P + L++
Sbjct: 834 LEGFTFNMAVRMIQNSPDNIELII 857
>gi|110346443 FERM and PDZ domain containing 2 like 1 isoform 2
[Homo sapiens]
Length = 261
Score = 531 bits (1369), Expect = e-151
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 60 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 119
MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL
Sbjct: 1 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 60
Query: 120 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP
Sbjct: 61 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Query: 180 GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 239
GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS
Sbjct: 121 GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 180
Query: 240 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 299
QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD
Sbjct: 181 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 240
Query: 300 IMRLGRYSFSSPLTRLSTDIF 320
IMRLGRYSFSSPLTRLSTDIF
Sbjct: 241 IMRLGRYSFSSPLTRLSTDIF 261
>gi|110346447 FERM and PDZ domain containing 2 like 2 isoform 2
[Homo sapiens]
Length = 261
Score = 531 bits (1369), Expect = e-151
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 60 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 119
MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL
Sbjct: 1 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 60
Query: 120 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP
Sbjct: 61 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Query: 180 GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 239
GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS
Sbjct: 121 GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 180
Query: 240 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 299
QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD
Sbjct: 181 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 240
Query: 300 IMRLGRYSFSSPLTRLSTDIF 320
IMRLGRYSFSSPLTRLSTDIF
Sbjct: 241 IMRLGRYSFSSPLTRLSTDIF 261
>gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo
sapiens]
Length = 261
Score = 530 bits (1366), Expect = e-151
Identities = 260/261 (99%), Positives = 261/261 (100%)
Query: 60 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 119
MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL
Sbjct: 1 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 60
Query: 120 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP
Sbjct: 61 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 120
Query: 180 GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 239
GALPE+EQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS
Sbjct: 121 GALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESS 180
Query: 240 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 299
QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD
Sbjct: 181 QKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCD 240
Query: 300 IMRLGRYSFSSPLTRLSTDIF 320
IMRLGRYSFSSPLTRLSTDIF
Sbjct: 241 IMRLGRYSFSSPLTRLSTDIF 261
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 155 bits (392), Expect = 5e-38
Identities = 101/249 (40%), Positives = 136/249 (54%), Gaps = 29/249 (11%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER--------RVPRSTQQCPSANDS 59
GDR+L V+GV L G THKQAV+ L+ GQV L+LE+ VP + Q S ++
Sbjct: 1420 GDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNA 1479
Query: 60 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 119
G V T + VT+ FEVKL KN++GLGFSF + + + + +
Sbjct: 1480 QGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI 1535
Query: 120 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
VR+K+LFPGQPA E+G I GD+IL VNG S +GL QEV+ LRG EV LLLCRPPP
Sbjct: 1536 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1595
Query: 180 GALPEMEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ----------EDSWRD 222
G LPE++ TP S + K+ ++ +C + TS ++ S RD
Sbjct: 1596 GVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRD 1655
Query: 223 SASPDAGEG 231
S S +G G
Sbjct: 1656 SYSDSSGSG 1664
Score = 56.2 bits (134), Expect = 4e-08
Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 9/101 (8%)
Query: 82 SVTDGPKFE---VKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGA 136
S+ P+ E V LKK+A GLGF + EK + DL + I + PG PA+ +G
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMG----RLDLGIFISSVAPGGPADLDGC 1137
Query: 137 IAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRP 177
+ GD +++VN S EG+ + +L+ AP++VTL++ +P
Sbjct: 1138 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQP 1178
Score = 53.1 bits (126), Expect = 3e-07
Identities = 36/91 (39%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 86 GPKFEVKLKKNANGLGFSF-VQMEKESCS-HLKSDLVRIKRLFPGQPAEENGAIAAGDII 143
G FEV+L KN N LG S V +K + ++ + +K + P AE +G I GD +
Sbjct: 1364 GDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRV 1423
Query: 144 LAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
LAVNG S EG ++ + LR Q V LLL
Sbjct: 1424 LAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1454
Score = 45.8 bits (107), Expect = 5e-05
Identities = 58/228 (25%), Positives = 86/228 (37%), Gaps = 45/228 (19%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTA 66
PGDRL++V+ + +TH AV L+ + RLV+ R
Sbjct: 1835 PGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR---------------------- 1872
Query: 67 VSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKR 124
V LP P + D + L N LGFS C S +V I
Sbjct: 1873 ---VLELPRIPMLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISD 1917
Query: 125 LFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPE 184
+ P A G + D+I VNG ST+G+ +EV L + + L R +P
Sbjct: 1918 INPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPS 1977
Query: 185 MEQEWQTPELSADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 230
++ +SA K + + SC+ P L DS+ A + E
Sbjct: 1978 SKRS----AVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 2021
Score = 31.6 bits (70), Expect = 0.98
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER 44
PGDRL+ V+ V L G++H A++ L+ + LV+ +
Sbjct: 1140 PGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 30.8 bits (68), Expect = 1.7
Identities = 14/47 (29%), Positives = 26/47 (55%)
Query: 130 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
PA+ +G + GD ++ VN + + ++LLR A + V L++ R
Sbjct: 1826 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1872
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 155 bits (392), Expect = 5e-38
Identities = 101/249 (40%), Positives = 136/249 (54%), Gaps = 29/249 (11%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER--------RVPRSTQQCPSANDS 59
GDR+L V+GV L G THKQAV+ L+ GQV L+LE+ VP + Q S ++
Sbjct: 1224 GDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNA 1283
Query: 60 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 119
G V T + VT+ FEVKL KN++GLGFSF + + + + +
Sbjct: 1284 QGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI 1339
Query: 120 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
VR+K+LFPGQPA E+G I GD+IL VNG S +GL QEV+ LRG EV LLLCRPPP
Sbjct: 1340 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1399
Query: 180 GALPEMEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ----------EDSWRD 222
G LPE++ TP S + K+ ++ +C + TS ++ S RD
Sbjct: 1400 GVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRD 1459
Query: 223 SASPDAGEG 231
S S +G G
Sbjct: 1460 SYSDSSGSG 1468
Score = 56.2 bits (134), Expect = 4e-08
Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 9/101 (8%)
Query: 82 SVTDGPKFE---VKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGA 136
S+ P+ E V LKK+A GLGF + EK + DL + I + PG PA+ +G
Sbjct: 891 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMG----RLDLGIFISSVAPGGPADLDGC 946
Query: 137 IAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRP 177
+ GD +++VN S EG+ + +L+ AP++VTL++ +P
Sbjct: 947 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQP 987
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/89 (40%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 86 GPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILA 145
G FEV+L KN N LG S S H + +K + P AE +G I GD +LA
Sbjct: 1173 GDIFEVELAKNDNSLGISVTGGVNTSVRH---GGIYVKAVIPQGAAESDGRIHKGDRVLA 1229
Query: 146 VNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
VNG S EG ++ + LR Q V LLL
Sbjct: 1230 VNGVSLEGATHKQAVETLRNTGQVVHLLL 1258
Score = 45.8 bits (107), Expect = 5e-05
Identities = 58/228 (25%), Positives = 86/228 (37%), Gaps = 45/228 (19%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTA 66
PGDRL++V+ + +TH AV L+ + RLV+ R
Sbjct: 1639 PGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR---------------------- 1676
Query: 67 VSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKR 124
V LP P + D + L N LGFS C S +V I
Sbjct: 1677 ---VLELPRIPMLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISD 1721
Query: 125 LFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPE 184
+ P A G + D+I VNG ST+G+ +EV L + + L R +P
Sbjct: 1722 INPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPS 1781
Query: 185 MEQEWQTPELSADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 230
++ +SA K + + SC+ P L DS+ A + E
Sbjct: 1782 SKRS----AVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 1825
Score = 31.6 bits (70), Expect = 0.98
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER 44
PGDRL+ V+ V L G++H A++ L+ + LV+ +
Sbjct: 949 PGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 986
Score = 30.8 bits (68), Expect = 1.7
Identities = 14/47 (29%), Positives = 26/47 (55%)
Query: 130 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
PA+ +G + GD ++ VN + + ++LLR A + V L++ R
Sbjct: 1630 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1676
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 155 bits (392), Expect = 5e-38
Identities = 101/249 (40%), Positives = 136/249 (54%), Gaps = 29/249 (11%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER--------RVPRSTQQCPSANDS 59
GDR+L V+GV L G THKQAV+ L+ GQV L+LE+ VP + Q S ++
Sbjct: 1415 GDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNA 1474
Query: 60 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 119
G V T + VT+ FEVKL KN++GLGFSF + + + + +
Sbjct: 1475 QGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI 1530
Query: 120 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
VR+K+LFPGQPA E+G I GD+IL VNG S +GL QEV+ LRG EV LLLCRPPP
Sbjct: 1531 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1590
Query: 180 GALPEMEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ----------EDSWRD 222
G LPE++ TP S + K+ ++ +C + TS ++ S RD
Sbjct: 1591 GVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRD 1650
Query: 223 SASPDAGEG 231
S S +G G
Sbjct: 1651 SYSDSSGSG 1659
Score = 56.2 bits (134), Expect = 4e-08
Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 9/101 (8%)
Query: 82 SVTDGPKFE---VKLKKNAN-GLGFSFVQMEKESCSHLKSDL-VRIKRLFPGQPAEENGA 136
S+ P+ E V LKK+A GLGF + EK + DL + I + PG PA+ +G
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMG----RLDLGIFISSVAPGGPADLDGC 1137
Query: 137 IAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRP 177
+ GD +++VN S EG+ + +L+ AP++VTL++ +P
Sbjct: 1138 LKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQP 1178
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/89 (40%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 86 GPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILA 145
G FEV+L KN N LG S S H + +K + P AE +G I GD +LA
Sbjct: 1364 GDIFEVELAKNDNSLGISVTGGVNTSVRH---GGIYVKAVIPQGAAESDGRIHKGDRVLA 1420
Query: 146 VNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
VNG S EG ++ + LR Q V LLL
Sbjct: 1421 VNGVSLEGATHKQAVETLRNTGQVVHLLL 1449
Score = 45.8 bits (107), Expect = 5e-05
Identities = 58/228 (25%), Positives = 86/228 (37%), Gaps = 45/228 (19%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTA 66
PGDRL++V+ + +TH AV L+ + RLV+ R
Sbjct: 1830 PGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR---------------------- 1867
Query: 67 VSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKR 124
V LP P + D + L N LGFS C S +V I
Sbjct: 1868 ---VLELPRIPMLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISD 1912
Query: 125 LFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPE 184
+ P A G + D+I VNG ST+G+ +EV L + + L R +P
Sbjct: 1913 INPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPS 1972
Query: 185 MEQEWQTPELSADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 230
++ +SA K + + SC+ P L DS+ A + E
Sbjct: 1973 SKRS----AVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 2016
Score = 31.6 bits (70), Expect = 0.98
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER 44
PGDRL+ V+ V L G++H A++ L+ + LV+ +
Sbjct: 1140 PGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1177
Score = 30.8 bits (68), Expect = 1.7
Identities = 14/47 (29%), Positives = 26/47 (55%)
Query: 130 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
PA+ +G + GD ++ VN + + ++LLR A + V L++ R
Sbjct: 1821 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1867
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 155 bits (392), Expect = 5e-38
Identities = 101/249 (40%), Positives = 136/249 (54%), Gaps = 29/249 (11%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER--------RVPRSTQQCPSANDS 59
GDR+L V+GV L G THKQAV+ L+ GQV L+LE+ VP + Q S ++
Sbjct: 1396 GDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNA 1455
Query: 60 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDL 119
G V T + VT+ FEVKL KN++GLGFSF + + + + +
Sbjct: 1456 QGQGPEKVKKTTQV----KDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI 1511
Query: 120 VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP 179
VR+K+LFPGQPA E+G I GD+IL VNG S +GL QEV+ LRG EV LLLCRPPP
Sbjct: 1512 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1571
Query: 180 GALPEMEQEWQTPELS-------ADKEFTRATCTDSCTSPILDQ----------EDSWRD 222
G LPE++ TP S + K+ ++ +C + TS ++ S RD
Sbjct: 1572 GVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRD 1631
Query: 223 SASPDAGEG 231
S S +G G
Sbjct: 1632 SYSDSSGSG 1640
Score = 57.0 bits (136), Expect = 2e-08
Identities = 42/132 (31%), Positives = 69/132 (52%), Gaps = 6/132 (4%)
Query: 48 RSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNAN-GLGFSFVQ 106
RS ++ +DS E + V + + S VS + V LKK+A GLGF +
Sbjct: 1032 RSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIG 1091
Query: 107 MEKESCSHLKSDL-VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRG 165
EK + DL + I + PG PA+ +G + GD +++VN S EG+ + +L+
Sbjct: 1092 GEKMG----RLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQN 1147
Query: 166 APQEVTLLLCRP 177
AP++VTL++ +P
Sbjct: 1148 APEDVTLVISQP 1159
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/89 (40%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 86 GPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILA 145
G FEV+L KN N LG S S H + +K + P AE +G I GD +LA
Sbjct: 1345 GDIFEVELAKNDNSLGISVTGGVNTSVRH---GGIYVKAVIPQGAAESDGRIHKGDRVLA 1401
Query: 146 VNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
VNG S EG ++ + LR Q V LLL
Sbjct: 1402 VNGVSLEGATHKQAVETLRNTGQVVHLLL 1430
Score = 45.8 bits (107), Expect = 5e-05
Identities = 58/228 (25%), Positives = 86/228 (37%), Gaps = 45/228 (19%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTA 66
PGDRL++V+ + +TH AV L+ + RLV+ R
Sbjct: 1811 PGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR---------------------- 1848
Query: 67 VSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS--DLVRIKR 124
V LP P + D + L N LGFS C S +V I
Sbjct: 1849 ---VLELPRIPMLPHLLPD-----ITLTCNKEELGFSL-------CGGHDSLYQVVYISD 1893
Query: 125 LFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPE 184
+ P A G + D+I VNG ST+G+ +EV L + + L R +P
Sbjct: 1894 INPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPS 1953
Query: 185 MEQEWQTPELSADK--EFTRATCTDSCTSPILDQEDSWRDSASPDAGE 230
++ +SA K + + SC+ P L DS+ A + E
Sbjct: 1954 SKRS----AVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINE 1997
Score = 31.6 bits (70), Expect = 0.98
Identities = 14/38 (36%), Positives = 24/38 (63%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER 44
PGDRL+ V+ V L G++H A++ L+ + LV+ +
Sbjct: 1121 PGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQ 1158
Score = 30.8 bits (68), Expect = 1.7
Identities = 14/47 (29%), Positives = 26/47 (55%)
Query: 130 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
PA+ +G + GD ++ VN + + ++LLR A + V L++ R
Sbjct: 1802 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR 1848
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 63.2 bits (152), Expect = 3e-10
Identities = 53/171 (30%), Positives = 83/171 (48%), Gaps = 16/171 (9%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGP-GQVARLVL---ERRVPRSTQQCPSANDSMGDE 63
GDR++ + G G+TH QAV LK G + V+ + V QQ P+++
Sbjct: 1881 GDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTG 1940
Query: 64 RTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIK 123
T+ S+ G P C S+T L++ +GLGFS V L + +K
Sbjct: 1941 LTSSSIFQDDLG-PPQCKSIT--------LERGPDGLGFSIVGGYGSPHGDLP---IYVK 1988
Query: 124 RLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
+F A E+G + GD I+AVNG+S EG+ +E + +L+ VTL++
Sbjct: 1989 TVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 61.2 bits (147), Expect = 1e-09
Identities = 56/197 (28%), Positives = 90/197 (45%), Gaps = 25/197 (12%)
Query: 6 FPGDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLVLERRVPRSTQQCPSANDSMGDER 64
F GD LL+V+G+ L G H+ V LK P +V + R VP +TQ + D E
Sbjct: 594 FSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIEL 653
Query: 65 TAVSLVTALPGRPSS-----CVSVTDGPKF----------------EVKLKKNANGLGFS 103
T V SS +++TD + ++L+K + GLGFS
Sbjct: 654 TEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFS 713
Query: 104 FVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLL 163
++ + S ++ I+ L PG AE++G + GD ++ VN + E +E + L
Sbjct: 714 I--LDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL 771
Query: 164 RGAPQ-EVTLLLCRPPP 179
+GAP V + + +P P
Sbjct: 772 KGAPSGTVRIGVAKPLP 788
Score = 56.2 bits (134), Expect = 4e-08
Identities = 47/179 (26%), Positives = 78/179 (43%), Gaps = 26/179 (14%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTA- 66
GD +L++ L G++ +Q Q L+ G +L++ R +ERTA
Sbjct: 299 GDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAI--------------EERTAP 344
Query: 67 VSLVTALPGRPSSCVSVT---------DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS 117
+L L P+S + + F+V+L KN GLG + + L+
Sbjct: 345 TALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDK--KLEP 402
Query: 118 DLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
+ +K + E +G I GD I+AV+G + +G Q+ + +LR Q V L L R
Sbjct: 403 SGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
Score = 55.5 bits (132), Expect = 6e-08
Identities = 57/220 (25%), Positives = 90/220 (40%), Gaps = 41/220 (18%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDE---- 63
GD+++ VDG L G T++QAV+ L+ GQ L L RR + + S D D
Sbjct: 425 GDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSP 484
Query: 64 --------------------RTAVSLVTALPGRP---SSCVSVTDGPKFEVKLK---KNA 97
R L T G P + + D K E L +
Sbjct: 485 VNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRI 544
Query: 98 NGLGFSFVQMEKESCSH-------LKSDLVR--IKRLFPGQPAEENGAIAAGDIILAVNG 148
G+ + V S L++ + I+ + P P +G + +GD +L VNG
Sbjct: 545 MGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNG 604
Query: 149 RSTEGLIFQEVLHLLRGAPQEVTLLLCR--PPPGALPEME 186
+ G Q+V+++L+ P EVT++ CR PP E++
Sbjct: 605 ITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELD 644
Score = 49.7 bits (117), Expect = 3e-06
Identities = 49/191 (25%), Positives = 77/191 (40%), Gaps = 28/191 (14%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDER--T 65
GD++L VD I+ G ++ + LK +L + P S Q PSA + E+ +
Sbjct: 1526 GDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDS-QAVPSAAGAASGEKKNS 1584
Query: 66 AVSLVTALPGRPS--------------------SCVSVTDGPKFEVKLKKNANGLGFSFV 105
+ SL+ G P + + G + +++ K GLG S V
Sbjct: 1585 SQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIV 1644
Query: 106 QMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRG 165
S + I ++ A ++G + AGD IL VNG E +++LR
Sbjct: 1645 -----GGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ 1699
Query: 166 APQEVTLLLCR 176
PQ V L L R
Sbjct: 1700 TPQRVRLTLYR 1710
Score = 48.5 bits (114), Expect = 8e-06
Identities = 44/182 (24%), Positives = 79/182 (43%), Gaps = 33/182 (18%)
Query: 9 DRLLQVDGVILCG-LTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
D++L ++G L +TH+QA+ L+ +LV+ R G V
Sbjct: 186 DQILAINGQALDQTITHQQAISILQKAKDTVQLVIAR----------------GSLPQLV 229
Query: 68 SLVTALPGRPSSCVSVTDGPKF-----EVKLKKNANGLGFSFVQMEKESCSHLKSDLVRI 122
S + + +S +S P ++L + +GLGF + K+ V +
Sbjct: 230 SPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG--------KATGVIV 281
Query: 123 KRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGAL 182
K + PG A+++G + +GD IL + G+ ++V +LR V L++ R GA+
Sbjct: 282 KTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR---GAI 338
Query: 183 PE 184
E
Sbjct: 339 EE 340
Score = 43.1 bits (100), Expect = 3e-04
Identities = 29/94 (30%), Positives = 51/94 (54%), Gaps = 7/94 (7%)
Query: 93 LKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTE 152
LK + GLGFS V + E+ L + ++ + G A +G + D ILA+NG++ +
Sbjct: 141 LKPPSGGLGFSVVGLRSENRGELG---IFVQEIQEGSVAHRDGRLKETDQILAINGQALD 197
Query: 153 GLI-FQEVLHLLRGAPQEVTLLLCRPPPGALPEM 185
I Q+ + +L+ A V L++ R G+LP++
Sbjct: 198 QTITHQQAISILQKAKDTVQLVIAR---GSLPQL 228
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/177 (23%), Positives = 79/177 (44%), Gaps = 23/177 (12%)
Query: 9 DRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQC----------PSAND 58
D LL+++G IL G +H+ A +K +++ R Q PS ++
Sbjct: 1396 DELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSE 1455
Query: 59 SMGDERTAVSLVTALPGRPSSCVSVTDGPKFE-VKLKKNANGLGFSFVQMEKESCSHLKS 117
++ ++ T ++ T+ + V ++ + ++L K+ GLG + E+++ S
Sbjct: 1456 NLQNKETEPTVTTS-----DAAVDLSSFKNVQHLELPKDQGGLGIAI--SEEDTLSG--- 1505
Query: 118 DLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
V IK L A +G + GD ILAV+ G ++ + LL+ A V L +
Sbjct: 1506 --VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/157 (26%), Positives = 65/157 (41%), Gaps = 37/157 (23%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GD++L+V+G+ L TH +A+ L+ Q RL L R + P + + D T
Sbjct: 1674 GDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR------DEAPYKEEEVCDTLT-- 1725
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
E++ KK GLG S V ++ + SD+V+
Sbjct: 1726 ---------------------IELQ-KKPGKGLGLSIVGKRNDTGVFV-SDIVK------ 1756
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLR 164
G A+ +G + GD IL VNG + V LL+
Sbjct: 1757 GGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793
Score = 33.5 bits (75), Expect = 0.26
Identities = 14/42 (33%), Positives = 27/42 (64%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPR 48
PGDR+++VDG+ L +H+QAV+ ++ G +++ + R
Sbjct: 1204 PGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINR 1245
Score = 32.7 bits (73), Expect = 0.44
Identities = 22/86 (25%), Positives = 40/86 (46%), Gaps = 5/86 (5%)
Query: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
++L+K +GLG S + S V I + P A ++G + D +L +NG+
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSRMS-----VFIVGIDPNGAAGKDGRLQIADELLEINGQI 1405
Query: 151 TEGLIFQEVLHLLRGAPQEVTLLLCR 176
G Q +++ AP +V ++ R
Sbjct: 1406 LYGRSHQNASSIIKCAPSKVKIIFIR 1431
Score = 30.8 bits (68), Expect = 1.7
Identities = 18/68 (26%), Positives = 30/68 (44%), Gaps = 4/68 (5%)
Query: 122 IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL----LLCRP 177
IK + PA +NG + GD I+ V+G ++ + +R A V ++ RP
Sbjct: 1187 IKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRP 1246
Query: 178 PPGALPEM 185
LP +
Sbjct: 1247 RKSPLPSL 1254
Score = 30.0 bits (66), Expect = 2.9
Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 1/47 (2%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLVLERRVPRSTQQ 52
PGDRL+ V+ V L + ++AV+ LKG P R+ + + +P S ++
Sbjct: 747 PGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEE 793
Score = 29.3 bits (64), Expect = 4.9
Identities = 14/51 (27%), Positives = 26/51 (50%)
Query: 122 IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL 172
I + P A + + GD I+ + G STEG+ + ++LL+ A + +
Sbjct: 1863 IAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1913
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 61.2 bits (147), Expect = 1e-09
Identities = 49/169 (28%), Positives = 79/169 (46%), Gaps = 7/169 (4%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GD +L++ G + G+T +Q Q L+ G R+++ R P A ++ V
Sbjct: 290 GDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAAL-----PV 344
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
+L T P S S+ + E+ ++K+ LG V S + S + +K + P
Sbjct: 345 ALPTVASKGPGSDSSLFETYNVEL-VRKDGQSLGIRIVGYVGTSHTGEASGIY-VKSIIP 402
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
G A NG I D I+AV+G + +G +V+ +LR A Q V L L R
Sbjct: 403 GSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451
Score = 54.3 bits (129), Expect = 1e-07
Identities = 45/159 (28%), Positives = 75/159 (47%), Gaps = 25/159 (15%)
Query: 22 LTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCV 81
++H+QA+ L+ RL++ R P T+ S + S+ D T LP
Sbjct: 197 ISHQQAIALLQQTTGSLRLIVARE-PVHTKS--STSSSLND--------TTLPE------ 239
Query: 82 SVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGD 141
+V G EV+L + +GLGF V K+ V ++ + PG A+ +G + GD
Sbjct: 240 TVCWGHVEEVELINDGSGLGFGIVGG--------KTSGVVVRTIVPGGLADRDGRLQTGD 291
Query: 142 IILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG 180
IL + G + +G+ ++V +LR V +L+ R P G
Sbjct: 292 HILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAG 330
Score = 45.4 bits (106), Expect = 7e-05
Identities = 59/226 (26%), Positives = 96/226 (42%), Gaps = 18/226 (7%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRV---------PRSTQQCPSAN 57
P D LL+V+G+ L G + ++AV LK LV RR+ PR T+ S
Sbjct: 600 PEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTE--TSLP 657
Query: 58 DSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKS 117
++ D V+ G +++ V+L K+ GLGFS + + + +S
Sbjct: 658 ETEVDHNMDVNTEEDDDGE----LALWSPEVKIVELVKDCKGLGFSILDYQ-DPLDPTRS 712
Query: 118 DLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQE-VTLLLCR 176
+V I+ L AE +G + GD +++VN + E + +L+ P V L +C+
Sbjct: 713 VIV-IRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICK 771
Query: 177 PPPGALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRD 222
P E + DK T D +S IL+ +RD
Sbjct: 772 PLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRD 817
Score = 42.4 bits (98), Expect = 6e-04
Identities = 62/280 (22%), Positives = 102/280 (36%), Gaps = 52/280 (18%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER--RVPRSTQQCPS-ANDSMGD-- 62
GD++L+V GV L +H +AV+ +K G +++ PR + AN G+
Sbjct: 1122 GDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQN 1181
Query: 63 ----ERTAVSLVTALPGR--PSSCVSVTD------------------------GPKFEVK 92
E+ TA P P ++TD G ++
Sbjct: 1182 QDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIE 1241
Query: 93 LKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTE 152
L+K+ NGLG S + S + + + P PA +G + GD +L +N +
Sbjct: 1242 LEKDKNGLGLSLAGNKDRSRMS-----IFVVGINPEGPAAADGRMRIGDELLEINNQILY 1296
Query: 153 GLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQEWQTPELSADKEFTRATCTDSCTSP 212
G Q +++ AP +V L+ R + P S + S T P
Sbjct: 1297 GRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPS-----SIEDQSGTEP 1351
Query: 213 ILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNR 252
I +ED G+ PES + +Q Q +
Sbjct: 1352 ISSEEDG-------SVEVGIKQLPESESFKLAVSQMKQQK 1384
Score = 41.2 bits (95), Expect = 0.001
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 6/100 (6%)
Query: 77 PSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGA 136
P++C + G + +++ K +GLG S V + + + I ++ A +G
Sbjct: 1425 PATC-PIVPGQEMIIEISKGRSGLGLSIVGGKDTPLN-----AIVIHEVYEEGAAARDGR 1478
Query: 137 IAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
+ AGD IL VNG +E + LR PQ+V L++ R
Sbjct: 1479 LWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 38.9 bits (89), Expect = 0.006
Identities = 47/175 (26%), Positives = 72/175 (41%), Gaps = 39/175 (22%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GD++L+V+GV L +H++A+ L+ Q RLV+ R +E +
Sbjct: 1482 GDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYR----------DEAHYRDEENLEI 1531
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNA-NGLGFSFVQMEKESCSHLKSDLVRIKRLF 126
F V L+K A GLG S V S + SD+V+
Sbjct: 1532 ---------------------FPVDLQKKAGRGLGLSIVGKRNGSGVFI-SDIVK----- 1564
Query: 127 PGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGA 181
G A+ +G + GD IL+VNG + V +L+ A V L + R G+
Sbjct: 1565 -GGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGS 1618
Score = 37.0 bits (84), Expect = 0.023
Identities = 49/225 (21%), Positives = 77/225 (34%), Gaps = 60/225 (26%)
Query: 9 DRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERT--- 65
D+++ VDGV + G + V+ L+ GQV L L R R T S + D T
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR---RKTSSSTSPLEPPSDRGTVVE 472
Query: 66 -----------AVSLVTALPGRP------------------SSCVSVTDGPKFEVKLK-K 95
AV T + G V D P+ E+K + +
Sbjct: 473 PLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWE 532
Query: 96 NANGLGFSFVQMEKESCSHLKSDLVRIKRLFP------------------------GQPA 131
N G + + ++ ++L + +L P G P
Sbjct: 533 NLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPV 592
Query: 132 EENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
+ G + D +L VNG G +E + L+ P TL+ CR
Sbjct: 593 DTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637
Score = 33.5 bits (75), Expect = 0.26
Identities = 21/86 (24%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 94 KKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS-TE 152
+ + GLGFS V + ++ + + +K + PG A+ + + D ILA+N +
Sbjct: 139 RPSTGGLGFSVVALRSQNLGKVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQ 195
Query: 153 GLIFQEVLHLLRGAPQEVTLLLCRPP 178
+ Q+ + LL+ + L++ R P
Sbjct: 196 NISHQQAIALLQQTTGSLRLIVAREP 221
Score = 31.2 bits (69), Expect = 1.3
Identities = 41/183 (22%), Positives = 76/183 (41%), Gaps = 21/183 (11%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER-RVPRSTQQCPSANDSMGDERTA 66
GD++L V+G + + + LK + +L + R R T ++ +S G +++A
Sbjct: 1577 GDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSA 1636
Query: 67 VS--------LVTALPGR--------PSSCVSVTDGPKFEVKLKKN-ANGLGFSFVQMEK 109
S ++T L PS S TD V++ + ++ LG S
Sbjct: 1637 HSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRG 1696
Query: 110 ESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQE 169
+ V I + A + GD I+++NG+ +GL +V++LL+ A
Sbjct: 1697 SPLGDIP---VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGR 1753
Query: 170 VTL 172
+ L
Sbjct: 1754 IIL 1756
Score = 28.5 bits (62), Expect = 8.3
Identities = 14/53 (26%), Positives = 25/53 (47%)
Query: 122 IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
IK++ PA + A+ GD IL V+G + E + ++ A V ++
Sbjct: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIV 1156
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 60.5 bits (145), Expect = 2e-09
Identities = 55/175 (31%), Positives = 84/175 (48%), Gaps = 15/175 (8%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCL------KGPGQVARLVLERRVPRSTQQCPSANDSMG 61
GD LL V+G L GL H ++ L K V + +++ P + Q+ P+AN
Sbjct: 2668 GDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGL 2727
Query: 62 DERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVR 121
R + L + GR V+V D EV K + GLG S ++ S +
Sbjct: 2728 LSRKTIPLEPGI-GRS---VAVHDALCVEVL--KTSAGLGLS---LDGGKSSVTGDGPLV 2778
Query: 122 IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
IKR++ G AE+ G I AGD ILA+NG+ GL+ + ++++ P+ LL R
Sbjct: 2779 IKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIR 2833
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/71 (36%), Positives = 36/71 (50%), Gaps = 3/71 (4%)
Query: 94 KKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEG 153
K+ GLGFS C + + +K +FP A E+G + GD IL VNG +G
Sbjct: 591 KEKGKGLGFSIAG--GRDCIRGQMGIF-VKTIFPNGSAAEDGRLKEGDEILDVNGIPIKG 647
Query: 154 LIFQEVLHLLR 164
L FQE +H +
Sbjct: 648 LTFQEAIHTFK 658
Score = 42.4 bits (98), Expect = 6e-04
Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 9/116 (7%)
Query: 51 QQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKE 110
Q+ S S+G + T ++L+ + + V F V +K +GLGFS
Sbjct: 2588 QRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVC----FIVLNRKEGSGLGFSVA----- 2638
Query: 111 SCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGA 166
+ ++ + + R+F A + G + GD +L+VNG S GL VL +L A
Sbjct: 2639 GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQA 2694
Score = 41.6 bits (96), Expect = 0.001
Identities = 61/235 (25%), Positives = 92/235 (39%), Gaps = 29/235 (12%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLK--GPGQVARLVLERRVPRSTQQC-----------P 54
GD +L V+G+ + GLT ++A+ K G V + V S C P
Sbjct: 634 GDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASP 693
Query: 55 SANDSMGDERTAVSLVTALPGRPSSCVSVTDGPK----FEVKLKKNAN-GLGFSFVQMEK 109
+ N S G S + G SS T GPK EV L K GLG +
Sbjct: 694 NFNTSGG-----ASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLAL 748
Query: 110 ESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLL-RGAPQ 168
E+ + I L PG A+ ++ GD IL VN + +V +L + P
Sbjct: 749 EN----SPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG 804
Query: 169 EVTLLLCRPPPGALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDS 223
V L++ R P + E E + + S +E A + +P+ + +DS
Sbjct: 805 PVRLVIGRHPNPKVSEQEMD-EVIARSTYQESKEANSSPGLGTPLKSPSLAKKDS 858
Score = 40.8 bits (94), Expect = 0.002
Identities = 32/133 (24%), Positives = 64/133 (48%), Gaps = 9/133 (6%)
Query: 43 ERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTD-GPKFEVKLKKNANGLG 101
E R+P++ ++ND + S + S C++ + G ++++L K ++GLG
Sbjct: 291 EHRIPKTDAPLTTSND-----KRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLG 345
Query: 102 FSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLH 161
+Q+ S + + ++ G A +G ++ GD +L +NG GL +E +
Sbjct: 346 ---IQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
Query: 162 LLRGAPQEVTLLL 174
+LR A V L++
Sbjct: 403 ILRSATGMVQLVV 415
Score = 32.3 bits (72), Expect = 0.58
Identities = 18/65 (27%), Positives = 36/65 (55%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GD LL ++G +L GL+H++AV L+ + +LV+ + + + S+ D ++V
Sbjct: 381 GDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSV 440
Query: 68 SLVTA 72
V++
Sbjct: 441 EDVSS 445
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 58.9 bits (141), Expect = 6e-09
Identities = 58/213 (27%), Positives = 92/213 (43%), Gaps = 29/213 (13%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGP---GQVARLVLERRVPRSTQQCPSANDSMGDE 63
PGD L+ VDG+ + G TH+ + + GQV L + R+V + CP S G
Sbjct: 821 PGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV-NLTVRRKVLCGGEPCPENGRSPGSV 879
Query: 64 RTAVS--------LVTALPGRPSSCVSVTDG------PKFEVKLKKNANGLGFSFVQMEK 109
T S + PSS S +G +V + + N GF FV +
Sbjct: 880 STHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENE-GFGFVIISS 938
Query: 110 ESCSHLKSDLV---RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGA 166
+ S + +I R+ G PA+ + GD ILAVNG+S + +++ L++ A
Sbjct: 939 LNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDA 998
Query: 167 PQEVTLLLCRPPPGALPEMEQEWQTPELSADKE 199
VTL + +P+ E T S++K+
Sbjct: 999 GLSVTLRI-------IPQEELNSPTSAPSSEKQ 1024
Score = 51.2 bits (121), Expect = 1e-06
Identities = 36/110 (32%), Positives = 52/110 (47%), Gaps = 9/110 (8%)
Query: 89 FEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNG 148
F V ++K A G GFS K DL + RL PA NG + GD I+ +NG
Sbjct: 1146 FTVDMEKGAKGFGFSI-----RGGREYKMDLY-VLRLAEDGPAIRNGRMRVGDQIIEING 1199
Query: 149 RSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQ--EWQTPELSA 196
ST + + L++ + V LLL R G +PE ++ W +P +A
Sbjct: 1200 ESTRDMTHARAIELIKSGGRRVRLLLKR-GTGQVPEYDEPAPWSSPAAAA 1248
Score = 38.5 bits (88), Expect = 0.008
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 14/82 (17%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLER---RVPRSTQQCPSANDSMGDER 64
GD++++++G +TH +A++ +K G+ RL+L+R +VP + P +
Sbjct: 1191 GDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWS-------- 1242
Query: 65 TAVSLVTALPGRPSSCVSVTDG 86
S A PG P VS+ DG
Sbjct: 1243 ---SPAAAAPGLPEVGVSLDDG 1261
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 58.9 bits (141), Expect = 6e-09
Identities = 59/210 (28%), Positives = 86/210 (40%), Gaps = 19/210 (9%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVA-------RLVLERRVPRSTQQCPSANDSM 60
GD+LL+V+GV L G H +AV+ L+G G R+V T P + S
Sbjct: 777 GDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSP 836
Query: 61 GDERTAVSLVTALPGRPSSCVSVTDGP---KFEVKLKKNANGLGFSFVQMEKESCSHLKS 117
+ R + LP P S GP + L ++ GLGFS + K S +
Sbjct: 837 RERRGGGLRLPLLP--PES-----PGPLRQRHVACLARSERGLGFS-IAGGKGSTPYRAG 888
Query: 118 DL-VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
D + + R+ G A G + GD +L++NG + LL A + LLL R
Sbjct: 889 DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER 948
Query: 177 PPPGALPEMEQEWQTPELSADKEFTRATCT 206
G LP +P +A + T T
Sbjct: 949 EAGGPLPPSPLPHSSPPTAAVATTSITTAT 978
Score = 58.2 bits (139), Expect = 1e-08
Identities = 59/192 (30%), Positives = 83/192 (43%), Gaps = 16/192 (8%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GDR+L ++GV + H AV L L+LER P + S A
Sbjct: 912 GDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVAT 971
Query: 68 -SLVTALPG-------RPSSCVSVTDGPK--FEVKLKKNANGLGFSFVQMEKESCSH--- 114
S+ TA PG PS + +GP E++L + LG S V S SH
Sbjct: 972 TSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHS-SHPFG 1030
Query: 115 LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
++ V I ++ P A +G + GD ILAVNG+ QE + L E++LL+
Sbjct: 1031 VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV 1089
Query: 175 CR-PPPGALPEM 185
R P P L E+
Sbjct: 1090 RRDPAPPGLREL 1101
Score = 42.4 bits (98), Expect = 6e-04
Identities = 42/168 (25%), Positives = 66/168 (39%), Gaps = 33/168 (19%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GDR+L V+G + TH++AV L P L++ RR P
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV-RRDP-------------------- 1093
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
A PG C+ G + + ++ A G + E + I ++ P
Sbjct: 1094 ----APPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEG--------IFISKVSP 1141
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLC 175
A +G + G +L VN +S GL E + LLR +T+L+C
Sbjct: 1142 TGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189
Score = 30.8 bits (68), Expect = 1.7
Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 95 KNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGL 154
+ GLG S + + + + I R+ PA G + GD +L VNG + +G
Sbjct: 733 RQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791
Query: 155 IFQEVLHLLRGAPQEVTLLLCR 176
E + LRGA V + + R
Sbjct: 792 EHHEAVEALRGAGTAVQMRVWR 813
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 58.9 bits (141), Expect = 6e-09
Identities = 59/210 (28%), Positives = 86/210 (40%), Gaps = 19/210 (9%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVA-------RLVLERRVPRSTQQCPSANDSM 60
GD+LL+V+GV L G H +AV+ L+G G R+V T P + S
Sbjct: 777 GDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSP 836
Query: 61 GDERTAVSLVTALPGRPSSCVSVTDGP---KFEVKLKKNANGLGFSFVQMEKESCSHLKS 117
+ R + LP P S GP + L ++ GLGFS + K S +
Sbjct: 837 RERRGGGLRLPLLP--PES-----PGPLRQRHVACLARSERGLGFS-IAGGKGSTPYRAG 888
Query: 118 DL-VRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 176
D + + R+ G A G + GD +L++NG + LL A + LLL R
Sbjct: 889 DAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLER 948
Query: 177 PPPGALPEMEQEWQTPELSADKEFTRATCT 206
G LP +P +A + T T
Sbjct: 949 EAGGPLPPSPLPHSSPPTAAVATTSITTAT 978
Score = 58.2 bits (139), Expect = 1e-08
Identities = 59/192 (30%), Positives = 83/192 (43%), Gaps = 16/192 (8%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GDR+L ++GV + H AV L L+LER P + S A
Sbjct: 912 GDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVAT 971
Query: 68 -SLVTALPG-------RPSSCVSVTDGPK--FEVKLKKNANGLGFSFVQMEKESCSH--- 114
S+ TA PG PS + +GP E++L + LG S V S SH
Sbjct: 972 TSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHS-SHPFG 1030
Query: 115 LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
++ V I ++ P A +G + GD ILAVNG+ QE + L E++LL+
Sbjct: 1031 VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV 1089
Query: 175 CR-PPPGALPEM 185
R P P L E+
Sbjct: 1090 RRDPAPPGLREL 1101
Score = 42.4 bits (98), Expect = 6e-04
Identities = 42/168 (25%), Positives = 66/168 (39%), Gaps = 33/168 (19%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GDR+L V+G + TH++AV L P L++ RR P
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV-RRDP-------------------- 1093
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
A PG C+ G + + ++ A G + E + I ++ P
Sbjct: 1094 ----APPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEG--------IFISKVSP 1141
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLC 175
A +G + G +L VN +S GL E + LLR +T+L+C
Sbjct: 1142 TGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189
Score = 30.8 bits (68), Expect = 1.7
Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 95 KNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGL 154
+ GLG S + + + + I R+ PA G + GD +L VNG + +G
Sbjct: 733 RQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGA 791
Query: 155 IFQEVLHLLRGAPQEVTLLLCR 176
E + LRGA V + + R
Sbjct: 792 EHHEAVEALRGAGTAVQMRVWR 813
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 57.8 bits (138), Expect = 1e-08
Identities = 55/180 (30%), Positives = 79/180 (43%), Gaps = 19/180 (10%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQ---VARLVLERRVPRSTQQCPSANDSM---- 60
GD LL VDGV L ++ +AV LK + L ++ P+ P+A DS
Sbjct: 555 GDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMA 614
Query: 61 --GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSD 118
D + + LP +C + V + A LGF V +E + +
Sbjct: 615 PPSDWSPSWVMWLELPRCLYNCKDI-------VLRRNTAGSLGFCIVGGYEE---YNGNK 664
Query: 119 LVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPP 178
IK + G PA +G I GDI+LAVNGRST G+I + LL+ +TL + P
Sbjct: 665 PFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWP 724
Score = 41.2 bits (95), Expect = 0.001
Identities = 46/187 (24%), Positives = 73/187 (39%), Gaps = 37/187 (19%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVP---RSTQQCPSANDSMGDE 63
PGD +L+V+G+ + + H AV+ L+ P QV L + R R+ Q P A D
Sbjct: 320 PGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDS 379
Query: 64 RTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNA--NGLGFSFVQMEKESCSHLKSDLVR 121
F V L K++ LG V+ E V
Sbjct: 380 -------------------------FHVILNKSSPEEQLGIKLVRKVDEPG-------VF 407
Query: 122 IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGA 181
I + G A +G + D +LA+NG + HL++ + + V L++ R
Sbjct: 408 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQR 467
Query: 182 LPEMEQE 188
P++ QE
Sbjct: 468 SPDIFQE 474
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 57.8 bits (138), Expect = 1e-08
Identities = 55/180 (30%), Positives = 79/180 (43%), Gaps = 19/180 (10%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQ---VARLVLERRVPRSTQQCPSANDSM---- 60
GD LL VDGV L ++ +AV LK + L ++ P+ P+A DS
Sbjct: 459 GDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMA 518
Query: 61 --GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSD 118
D + + LP +C + V + A LGF V +E + +
Sbjct: 519 PPSDWSPSWVMWLELPRCLYNCKDI-------VLRRNTAGSLGFCIVGGYEE---YNGNK 568
Query: 119 LVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPP 178
IK + G PA +G I GDI+LAVNGRST G+I + LL+ +TL + P
Sbjct: 569 PFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWP 628
Score = 41.2 bits (95), Expect = 0.001
Identities = 46/187 (24%), Positives = 73/187 (39%), Gaps = 37/187 (19%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVP---RSTQQCPSANDSMGDE 63
PGD +L+V+G+ + + H AV+ L+ P QV L + R R+ Q P A D
Sbjct: 224 PGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDS 283
Query: 64 RTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNA--NGLGFSFVQMEKESCSHLKSDLVR 121
F V L K++ LG V+ E V
Sbjct: 284 -------------------------FHVILNKSSPEEQLGIKLVRKVDEPG-------VF 311
Query: 122 IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGA 181
I + G A +G + D +LA+NG + HL++ + + V L++ R
Sbjct: 312 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQR 371
Query: 182 LPEMEQE 188
P++ QE
Sbjct: 372 SPDIFQE 378
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 55.5 bits (132), Expect = 6e-08
Identities = 54/180 (30%), Positives = 87/180 (48%), Gaps = 19/180 (10%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVL--------ERRVPRSTQQCPSANDS 59
GD LL ++G+ L L+H +AV LK + L E + +Q + +++
Sbjct: 516 GDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSEN 575
Query: 60 MGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGL-GFSFVQMEKESCSHLKSD 118
D + S V L G PS+ S D + L+++ G GFS V +E+ H
Sbjct: 576 EYDASWSPSWVMWL-GLPSTLHSCHD-----IVLRRSYLGSWGFSIVGGYEEN--HTNQP 627
Query: 119 LVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL-LLCRP 177
IK + G PA +G + GD+I+AVNG ST G+ ++ +L+ +VTL ++C P
Sbjct: 628 FF-IKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWP 686
Score = 32.3 bits (72), Expect = 0.58
Identities = 38/172 (22%), Positives = 66/172 (38%), Gaps = 32/172 (18%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GD++LQV+ + ++H A L P L + R R + + +DS
Sbjct: 280 GDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRE-RRFGNRAHNHSDSNSPREEI- 337
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANG--LGFSFVQMEKESCSHLKSDLVRIKRL 125
F+V L K +G LG V+ E V I L
Sbjct: 338 ---------------------FQVALHKRDSGEQLGIKLVRRTDEPG-------VFILDL 369
Query: 126 FPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRP 177
G A ++G +++ D +LA+NG + + +++ + + V L + RP
Sbjct: 370 LEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARP 421
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 54.3 bits (129), Expect = 1e-07
Identities = 34/100 (34%), Positives = 55/100 (55%), Gaps = 7/100 (7%)
Query: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
V+L K GLGF+ + ++++ + I R+ PG AE +G + GD +L+VNG S
Sbjct: 109 VELPKTDEGLGFNVMGGKEQNSP------IYISRIIPGGVAERHGGLKRGDQLLSVNGVS 162
Query: 151 TEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQEWQ 190
EG ++ + LL+ A V L++ R P L EME ++
Sbjct: 163 VEGEHHEKAVELLKAAKDSVKLVV-RYTPKVLEEMEARFE 201
Score = 30.4 bits (67), Expect = 2.2
Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 1/45 (2%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQ 52
GD+LL V+GV + G H++AV+ LK +LV+ R P+ ++
Sbjct: 152 GDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVV-RYTPKVLEE 195
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 53.9 bits (128), Expect = 2e-07
Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 24/186 (12%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLV--------LERRVPRSTQQCPSAND 58
GDRL++V+GV + G TH Q VQ +K GQ LV L RR T++
Sbjct: 53 GDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGL 112
Query: 59 SMGDERTAVSLVTALPGRPSSCVSVTD--GPKFEVK-----LKKNANGLGFSFVQMEKES 111
+ A G SS D GP E++ L+K G GF+ +
Sbjct: 113 PPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRP 172
Query: 112 CSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVT 171
+++S + PG PA +G + A D ++ VNG++ EGL EV+ ++ E
Sbjct: 173 GQYIRS-------VDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEAR 224
Query: 172 LLLCRP 177
LL+ P
Sbjct: 225 LLVVDP 230
Score = 36.2 bits (82), Expect = 0.040
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 7/81 (8%)
Query: 122 IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGA 181
I+R+ PG PAE A+ AGD ++ VNG + EG +V+ ++ + LL+
Sbjct: 36 IRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVD----- 89
Query: 182 LPEMEQEWQTPELSADKEFTR 202
E ++E + +L+ +E +
Sbjct: 90 -QETDEELRRRQLTCTEEMAQ 109
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 53.9 bits (128), Expect = 2e-07
Identities = 55/186 (29%), Positives = 82/186 (44%), Gaps = 24/186 (12%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKG-PGQVARLV--------LERRVPRSTQQCPSAND 58
GDRL++V+GV + G TH Q VQ +K GQ LV L RR T++
Sbjct: 53 GDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGL 112
Query: 59 SMGDERTAVSLVTALPGRPSSCVSVTD--GPKFEVK-----LKKNANGLGFSFVQMEKES 111
+ A G SS D GP E++ L+K G GF+ +
Sbjct: 113 PPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRP 172
Query: 112 CSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVT 171
+++S + PG PA +G + A D ++ VNG++ EGL EV+ ++ E
Sbjct: 173 GQYIRS-------VDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEAR 224
Query: 172 LLLCRP 177
LL+ P
Sbjct: 225 LLVVDP 230
Score = 36.2 bits (82), Expect = 0.040
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 7/81 (8%)
Query: 122 IKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGA 181
I+R+ PG PAE A+ AGD ++ VNG + EG +V+ ++ + LL+
Sbjct: 36 IRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVD----- 89
Query: 182 LPEMEQEWQTPELSADKEFTR 202
E ++E + +L+ +E +
Sbjct: 90 -QETDEELRRRQLTCTEEMAQ 109
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 53.5 bits (127), Expect = 2e-07
Identities = 33/100 (33%), Positives = 56/100 (56%), Gaps = 7/100 (7%)
Query: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
V+L K GLGF+ + ++++ + I R+ PG A+ +G + GD +L+VNG S
Sbjct: 94 VELPKTEEGLGFNIMGGKEQNSP------IYISRIIPGGIADRHGGLKRGDQLLSVNGVS 147
Query: 151 TEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQEWQ 190
EG ++ + LL+ A +V L++ R P L EME ++
Sbjct: 148 VEGEHHEKAVELLKAAQGKVKLVV-RYTPKVLEEMESRFE 186
Score = 31.6 bits (70), Expect = 0.98
Identities = 19/53 (35%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSM 60
GD+LL V+GV + G H++AV+ LK +LV+ R P+ ++ S + M
Sbjct: 137 GDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV-RYTPKVLEEMESRFEKM 188
>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
Length = 1434
Score = 53.1 bits (126), Expect = 3e-07
Identities = 39/97 (40%), Positives = 50/97 (51%), Gaps = 14/97 (14%)
Query: 94 KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
K+ GLGF + KE S + SDL+R G AE++G I AGDIILAVNGR
Sbjct: 22 KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71
Query: 151 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPEME 186
L + L +LRG E +L+ R P G +E
Sbjct: 72 LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 52.8 bits (125), Expect = 4e-07
Identities = 55/192 (28%), Positives = 85/192 (44%), Gaps = 15/192 (7%)
Query: 53 CPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESC 112
CP A + G R SL TA +PS + + V +K A GLGFS V +
Sbjct: 182 CP-AGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNI-VLMKGQAKGLGFSIVGGKDSIY 239
Query: 113 SHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL 172
+ + +K +F G A +G + GD IL +NG S GL Q+ L + A + +
Sbjct: 240 GPIG---IYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLT 296
Query: 173 LLCRPPPGALPEMEQEWQTP---ELSADKEFTRATCT---DSCTSPILDQEDSWR----D 222
L R A P + P LS+ T+ + + +S ++PI + ++R
Sbjct: 297 LTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEV 356
Query: 223 SASPDAGEGLGL 234
S +AG GLG+
Sbjct: 357 SLQKEAGVGLGI 368
Score = 51.6 bits (122), Expect = 9e-07
Identities = 29/103 (28%), Positives = 55/103 (53%), Gaps = 7/103 (6%)
Query: 85 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 144
DG + K+ GLGFS + L++ ++ + R+FP A + G I G+ +L
Sbjct: 1109 DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163
Query: 145 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEM 185
++NG+S +G + L +LR A P++ ++ + P A+P++
Sbjct: 1164 SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 1206
Score = 51.2 bits (121), Expect = 1e-06
Identities = 44/172 (25%), Positives = 76/172 (44%), Gaps = 15/172 (8%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERR--VPRSTQQCPSANDSMGDERT 65
G+ +L ++G L G TH A+ L+ + + V+ R P + S+ DS
Sbjct: 1159 GNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA 1218
Query: 66 AVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRL 125
A + + C V L+K + GLGFS +E S + I R+
Sbjct: 1219 ASDVSVESTAEATVCT---------VTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRI 1266
Query: 126 FPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 176
F G +E++ + GD IL + G + +GL E ++++ P VT+++ R
Sbjct: 1267 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
Score = 47.0 bits (110), Expect = 2e-05
Identities = 62/272 (22%), Positives = 104/272 (38%), Gaps = 21/272 (7%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQ-VARLVLERRVPR--------STQQCPSAND 58
GD +L+++G + GLTH+ A+Q K + + L + R+ S C S +
Sbjct: 264 GDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSS 323
Query: 59 SMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNAN-GLGFSFVQMEKESCSHLKS 117
S + + S P P S EV L+K A GLG + C
Sbjct: 324 STCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQC----I 379
Query: 118 DLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGA-PQEVTLLLCR 176
+ + L PG A +G + GD I+ ++ L EV +L P V +++ R
Sbjct: 380 SGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
Query: 177 PPPGALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRP 236
P + E + + + + +F + S + E SW + + R
Sbjct: 440 HPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEG-VKRLESSWHGRPTLEKE-----RE 493
Query: 237 ESSQKAIREAQWGQNRERPWASSLTHSPESHP 268
++S R AQ R +S ++ SP P
Sbjct: 494 KNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSP 525
Score = 29.6 bits (65), Expect = 3.7
Identities = 16/53 (30%), Positives = 27/53 (50%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDS 59
PGD +LQ+ G + GLT +A +K ++ RR +++ +A DS
Sbjct: 1280 PGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 52.8 bits (125), Expect = 4e-07
Identities = 58/234 (24%), Positives = 84/234 (35%), Gaps = 36/234 (15%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GDRLL VDG+ L G +H A+ L+ A +E V
Sbjct: 293 GDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDV--------------------- 331
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
A P V+ GP +K + LG S + S ++ I R+ P
Sbjct: 332 ----ATP----DTVANASGPLMVEIVKTPGSALGISLT-----TTSLRNKSVITIDRIKP 378
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQ 187
+ +GA+ GD IL+++G S E E LL ++V L + P P Q
Sbjct: 379 ASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPQ 438
Query: 188 EWQTPELSADKEFTRATCTDSCTSPILD--QEDSWRDSASPDAGEGLGLRPESS 239
+++ C SC SP + +W A D L P SS
Sbjct: 439 RQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSS 492
Score = 48.9 bits (115), Expect = 6e-06
Identities = 47/166 (28%), Positives = 68/166 (40%), Gaps = 35/166 (21%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTA 66
PGD+LL +D + L + AVQ L+ + +L + + DE +
Sbjct: 700 PGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRK-----------------DEDNS 742
Query: 67 VSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLF 126
L T T + V+LK+ LG + E+ D + I L
Sbjct: 743 DELET------------TGAVSYTVELKRYGGPLGITISGTEEPF------DPIVISGLT 784
Query: 127 PGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL 172
AE GAI GD ILA+N S +G E +HLL+ A + VTL
Sbjct: 785 KRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGETVTL 830
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/190 (25%), Positives = 72/190 (37%), Gaps = 40/190 (21%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GD + V+G+ L L H + + LK G+ L +E +P P A
Sbjct: 190 GDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELP------PPA----------- 232
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
P +S T +V L K N GF E H LV + + P
Sbjct: 233 ------PENNPRIISKT----VDVSLYKEGNSFGFVLRGGAHED-GHKSRPLV-LTYVRP 280
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQ 187
G PA+ G++ GD +L+V+G G L LR E AL ++E
Sbjct: 281 GGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHE-----------ALFQVEY 329
Query: 188 EWQTPELSAD 197
+ TP+ A+
Sbjct: 330 DVATPDTVAN 339
Score = 35.0 bits (79), Expect = 0.089
Identities = 17/40 (42%), Positives = 23/40 (57%)
Query: 127 PGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGA 166
P PAE G + GD +L++NG +TE +E LLR A
Sbjct: 590 PDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDA 629
Score = 31.6 bits (70), Expect = 0.98
Identities = 36/166 (21%), Positives = 62/166 (37%), Gaps = 36/166 (21%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GDR+L ++G+ T ++A Q L+ ++VLE + PS+
Sbjct: 603 GDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEFDVAESVIPSSGT--------- 653
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKL-KKNANGLGFSFVQMEKESCSHLKSDLVRIKRLF 126
F VKL KK + LG + S S + + + I +
Sbjct: 654 ---------------------FHVKLPKKRSVELGITI-----SSASRKRGEPLIISDIK 687
Query: 127 PGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL 172
G A G + GD +LA++ + ++ + +LR V L
Sbjct: 688 KGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKL 733
Score = 31.2 bits (69), Expect = 1.3
Identities = 20/64 (31%), Positives = 29/64 (45%)
Query: 121 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPG 180
R+ L PG A + + GD I +VNG L E++ LL+ + V L + P
Sbjct: 171 RVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPP 230
Query: 181 ALPE 184
PE
Sbjct: 231 PAPE 234
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 52.4 bits (124), Expect = 5e-07
Identities = 48/166 (28%), Positives = 66/166 (39%), Gaps = 34/166 (20%)
Query: 7 PGDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTA 66
PGDRLL VDG+ L G TH +A+ LK GQ A L++E V S DS
Sbjct: 199 PGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDV--------SVMDS------- 243
Query: 67 VSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLF 126
V+ GP K LG V + C + ++ I ++
Sbjct: 244 --------------VATASGPLLVEVAKTPGASLG---VALTTSMCCN--KQVIVIDKIK 284
Query: 127 PGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL 172
A+ GA+ GD IL+++G S E E L +V L
Sbjct: 285 SASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL 330
Score = 51.2 bits (121), Expect = 1e-06
Identities = 73/315 (23%), Positives = 117/315 (37%), Gaps = 68/315 (21%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GD+LL +D + L + + AVQ L+ + +L + + S +Q E +
Sbjct: 568 GDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQ----------ESSGA 617
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
+ T V+LK+ LG + E+ D + I L
Sbjct: 618 IIYT-------------------VELKRYGGPLGITISGTEEPF------DPIIISSLTK 652
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPP-------- 179
G AE GAI GD ILA+N S +G E +HLL+ A + VTL + +
Sbjct: 653 GGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPK 712
Query: 180 -----------GALPEMEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDA 228
G + E Q P +D + DS DSW SA +
Sbjct: 713 KFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDSAV-------DSWDGSAIDTS 765
Query: 229 GEGLGLRPESSQKAIREAQWGQNRERPWASSLTH-SPESHPHLCKLHQERDEST------ 281
G ++S W ++R S +T +++P + +++ D ST
Sbjct: 766 YGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAG 825
Query: 282 LATSLEKDVRQNCYS 296
A S E + +N +S
Sbjct: 826 AADSAETEQEENFWS 840
Score = 44.7 bits (104), Expect = 1e-04
Identities = 45/167 (26%), Positives = 66/167 (39%), Gaps = 30/167 (17%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAV 67
GD + V+G+ L H + + LK G+ L +E +P + Q
Sbjct: 98 GDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQ--------------- 142
Query: 68 SLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFP 127
SS + T EV L K N GF + + KS V I + P
Sbjct: 143 ---------GSSVIFRT----VEVTLHKEGNTFGFVIRGGAHDDRN--KSRPVVITCVRP 187
Query: 128 GQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLL 174
G PA+ G I GD +L+V+G G E + +L+ QE LL+
Sbjct: 188 GGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
Score = 34.7 bits (78), Expect = 0.12
Identities = 16/35 (45%), Positives = 21/35 (60%)
Query: 130 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLR 164
PAE G + GD ++A+NG TE F+E LLR
Sbjct: 459 PAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLR 493
Score = 30.0 bits (66), Expect = 2.9
Identities = 22/80 (27%), Positives = 37/80 (46%), Gaps = 1/80 (1%)
Query: 121 RIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL-LLCRPPP 179
R+ L G A + + GD I AVNG + E++ LL+ + V L + PP
Sbjct: 79 RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPP 138
Query: 180 GALPEMEQEWQTPELSADKE 199
++ ++T E++ KE
Sbjct: 139 VSVQGSSVIFRTVEVTLHKE 158
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 52.4 bits (124), Expect = 5e-07
Identities = 33/100 (33%), Positives = 55/100 (55%), Gaps = 7/100 (7%)
Query: 91 VKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
V+L K GLGF+ + ++++ + I R+ PG A+ +G + GD +L+VNG S
Sbjct: 94 VELPKTDEGLGFNIMGGKEQNSP------IYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
Query: 151 TEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPEMEQEWQ 190
EG ++ + LL+ A V L++ R P L EME ++
Sbjct: 148 VEGEQHEKAVELLKAAQGSVKLVV-RYTPRVLEEMEARFE 186
Score = 32.7 bits (73), Expect = 0.44
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 1/57 (1%)
Query: 8 GDRLLQVDGVILCGLTHKQAVQCLKGPGQVARLVLERRVPRSTQQCPSANDSMGDER 64
GD+LL V+GV + G H++AV+ LK +LV+ R PR ++ + + M R
Sbjct: 137 GDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV-RYTPRVLEEMEARFEKMRSAR 192
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,596,018
Number of Sequences: 37866
Number of extensions: 715968
Number of successful extensions: 2585
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 2118
Number of HSP's gapped (non-prelim): 433
length of query: 320
length of database: 18,247,518
effective HSP length: 102
effective length of query: 218
effective length of database: 14,385,186
effective search space: 3135970548
effective search space used: 3135970548
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.