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Search of human proteins with 149363666
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo
sapiens]
(606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 1203 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 1203 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 1203 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 887 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 887 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 833 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 833 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 833 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 826 0.0
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 826 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 826 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 735 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 688 0.0
gi|4505677 phosphodiesterase 1B [Homo sapiens] 238 1e-62
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 234 2e-61
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 234 2e-61
gi|4826894 phosphodiesterase 1C [Homo sapiens] 229 4e-60
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 224 2e-58
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 224 2e-58
gi|9506959 phosphodiesterase 7B [Homo sapiens] 213 4e-55
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 209 6e-54
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 209 6e-54
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 209 6e-54
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 209 6e-54
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 209 6e-54
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 208 1e-53
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 194 2e-49
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 171 2e-42
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 171 2e-42
gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens] 171 2e-42
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 1203 bits (3112), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR
Sbjct: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
Query: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR
Sbjct: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
Query: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 180
HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP
Sbjct: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 180
Query: 181 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 240
MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL
Sbjct: 181 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 240
Query: 241 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 300
TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT
Sbjct: 241 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 300
Query: 301 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 360
PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF
Sbjct: 301 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 360
Query: 361 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 420
KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL
Sbjct: 361 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 420
Query: 421 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 480
LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC
Sbjct: 421 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 480
Query: 481 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 540
DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT
Sbjct: 481 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 540
Query: 541 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 600
NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP
Sbjct: 541 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 600
Query: 601 LDNQRT 606
LDNQRT
Sbjct: 601 LDNQRT 606
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 1203 bits (3112), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR
Sbjct: 75 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 134
Query: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR
Sbjct: 135 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 194
Query: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 180
HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP
Sbjct: 195 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 254
Query: 181 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 240
MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL
Sbjct: 255 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 314
Query: 241 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 300
TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT
Sbjct: 315 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 374
Query: 301 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 360
PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF
Sbjct: 375 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 434
Query: 361 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 420
KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL
Sbjct: 435 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 494
Query: 421 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 480
LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC
Sbjct: 495 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 554
Query: 481 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 540
DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT
Sbjct: 555 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 614
Query: 541 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 600
NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP
Sbjct: 615 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 674
Query: 601 LDNQRT 606
LDNQRT
Sbjct: 675 LDNQRT 680
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 1203 bits (3112), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR
Sbjct: 107 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 166
Query: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR
Sbjct: 167 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 226
Query: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 180
HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP
Sbjct: 227 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQP 286
Query: 181 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 240
MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL
Sbjct: 287 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPL 346
Query: 241 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 300
TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT
Sbjct: 347 TAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLAT 406
Query: 301 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 360
PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF
Sbjct: 407 PALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGF 466
Query: 361 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 420
KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL
Sbjct: 467 KLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVL 526
Query: 421 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 480
LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC
Sbjct: 527 LLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMC 586
Query: 481 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 540
DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT
Sbjct: 587 DKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLT 646
Query: 541 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 600
NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP
Sbjct: 647 NPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLP 706
Query: 601 LDNQRT 606
LDNQRT
Sbjct: 707 LDNQRT 712
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 887 bits (2292), Expect = 0.0
Identities = 450/611 (73%), Positives = 516/611 (84%), Gaps = 12/611 (1%)
Query: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
+QA HSQRRESFLYRSDSDY+LSPK+MSRNSS+ASD+HG+D+IVTPFAQVLASLRTVR
Sbjct: 178 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 237
Query: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
+N AAL Q +K+ P+ N S N+ E+ QKLA ETL+ELDWCLDQLETLQTR
Sbjct: 238 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 297
Query: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ- 179
HSV EMASNKFKR+LNRELTHLSE SRSGNQVSE+IS TFLD+Q EVE+P T +E +
Sbjct: 298 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 357
Query: 180 --PMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGN 237
PMS+ISG+ L HS+SL+++++PRFGV+T+QE+ LAKELED NKWGL VF++AELSGN
Sbjct: 358 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 417
Query: 238 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 297
RPLT I+ +IFQERDLLKTF+IP DTL TYL+ LE HYHA+VAYHN++HAADV QSTHVL
Sbjct: 418 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 477
Query: 298 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 357
L+TPALEAVFTDLEILAA+FASAIHDVDHPGVSNQFLINTNSELALMYND+SVLENHHLA
Sbjct: 478 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 537
Query: 358 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 417
VGFKLLQ ENCDIFQNL+ KQR SLR+MVID+VLATDMSKHMNLLADLKTMVETKKVTS
Sbjct: 538 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 597
Query: 418 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 477
GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL LYRQWTDRIM EFF+QGDRERE G++IS
Sbjct: 598 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 657
Query: 478 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS 537
PMCDKH ASVEKSQVGFIDYI HPLWETWADLVHPDAQD+LDTLEDNREWYQS IP+SPS
Sbjct: 658 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 717
Query: 538 DLTNPERDG----PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAG 593
+ +G ++FQFELTLEE E D E++ + +E D++ L +
Sbjct: 718 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQ----VEEDTSCSDSKTLCTQ-D 772
Query: 594 PDPGDLPLDNQ 604
+ ++PLD Q
Sbjct: 773 SESTEIPLDEQ 783
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 887 bits (2292), Expect = 0.0
Identities = 450/611 (73%), Positives = 516/611 (84%), Gaps = 12/611 (1%)
Query: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
+QA HSQRRESFLYRSDSDY+LSPK+MSRNSS+ASD+HG+D+IVTPFAQVLASLRTVR
Sbjct: 42 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR 101
Query: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
+N AAL Q +K+ P+ N S N+ E+ QKLA ETL+ELDWCLDQLETLQTR
Sbjct: 102 NNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTR 161
Query: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQ- 179
HSV EMASNKFKR+LNRELTHLSE SRSGNQVSE+IS TFLD+Q EVE+P T +E +
Sbjct: 162 HSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKK 221
Query: 180 --PMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGN 237
PMS+ISG+ L HS+SL+++++PRFGV+T+QE+ LAKELED NKWGL VF++AELSGN
Sbjct: 222 KRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGN 281
Query: 238 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 297
RPLT I+ +IFQERDLLKTF+IP DTL TYL+ LE HYHA+VAYHN++HAADV QSTHVL
Sbjct: 282 RPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVL 341
Query: 298 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 357
L+TPALEAVFTDLEILAA+FASAIHDVDHPGVSNQFLINTNSELALMYND+SVLENHHLA
Sbjct: 342 LSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA 401
Query: 358 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 417
VGFKLLQ ENCDIFQNL+ KQR SLR+MVID+VLATDMSKHMNLLADLKTMVETKKVTS
Sbjct: 402 VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSS 461
Query: 418 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 477
GVLLLDNYSDRIQVLQN+VHCADLSNPTKPL LYRQWTDRIM EFF+QGDRERE G++IS
Sbjct: 462 GVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEIS 521
Query: 478 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS 537
PMCDKH ASVEKSQVGFIDYI HPLWETWADLVHPDAQD+LDTLEDNREWYQS IP+SPS
Sbjct: 522 PMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPS 581
Query: 538 DLTNPERDG----PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAG 593
+ +G ++FQFELTLEE E D E++ + +E D++ L +
Sbjct: 582 PAPDDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQ----VEEDTSCSDSKTLCTQ-D 636
Query: 594 PDPGDLPLDNQ 604
+ ++PLD Q
Sbjct: 637 SESTEIPLDEQ 647
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 833 bits (2153), Expect = 0.0
Identities = 433/606 (71%), Positives = 494/606 (81%), Gaps = 30/606 (4%)
Query: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
+ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+IVTPFAQVLASLR+VR
Sbjct: 72 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR 131
Query: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
SN + L + + K+ P+G P+ + +E+T Q+LA ETL+ELDWCL+QLET+QT
Sbjct: 132 SNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTY 190
Query: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE---- 176
SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E
Sbjct: 191 RSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQ 250
Query: 177 -AP---------------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELED 220
AP QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+
Sbjct: 251 QAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELEN 310
Query: 221 TNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVA 280
NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VA
Sbjct: 311 LNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVA 370
Query: 281 YHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSE 340
YHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSE
Sbjct: 371 YHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSE 430
Query: 341 LALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMN 400
LALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM
Sbjct: 431 LALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMT 490
Query: 401 LLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMA 460
LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMA
Sbjct: 491 LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMA 550
Query: 461 EFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDT 520
EFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDT
Sbjct: 551 EFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDT 610
Query: 521 LEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETA 574
LEDNR+WY S I +SPS E G PD+FQFELTL EEE+EEE +
Sbjct: 611 LEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPC 667
Query: 575 LAKEAL 580
A+EAL
Sbjct: 668 TAQEAL 673
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 833 bits (2153), Expect = 0.0
Identities = 433/606 (71%), Positives = 494/606 (81%), Gaps = 30/606 (4%)
Query: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
+ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+IVTPFAQVLASLR+VR
Sbjct: 107 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR 166
Query: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
SN + L + + K+ P+G P+ + +E+T Q+LA ETL+ELDWCL+QLET+QT
Sbjct: 167 SNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTY 225
Query: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE---- 176
SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E
Sbjct: 226 RSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQ 285
Query: 177 -AP---------------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELED 220
AP QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+
Sbjct: 286 QAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELEN 345
Query: 221 TNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVA 280
NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VA
Sbjct: 346 LNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVA 405
Query: 281 YHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSE 340
YHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSE
Sbjct: 406 YHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSE 465
Query: 341 LALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMN 400
LALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM
Sbjct: 466 LALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMT 525
Query: 401 LLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMA 460
LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMA
Sbjct: 526 LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMA 585
Query: 461 EFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDT 520
EFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDT
Sbjct: 586 EFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDT 645
Query: 521 LEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETA 574
LEDNR+WY S I +SPS E G PD+FQFELTL EEE+EEE +
Sbjct: 646 LEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPC 702
Query: 575 LAKEAL 580
A+EAL
Sbjct: 703 TAQEAL 708
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 833 bits (2153), Expect = 0.0
Identities = 433/606 (71%), Positives = 494/606 (81%), Gaps = 30/606 (4%)
Query: 1 MQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVR 60
+ A SQRRESFLYRSDSDY++SPK MSRNSSV S+ H ED+IVTPFAQVLASLR+VR
Sbjct: 133 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR 192
Query: 61 SNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTR 120
SN + L + + K+ P+G P+ + +E+T Q+LA ETL+ELDWCL+QLET+QT
Sbjct: 193 SNFSLLTNVP-VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTY 251
Query: 121 HSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE---- 176
SV EMAS+KFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E
Sbjct: 252 RSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQ 311
Query: 177 -AP---------------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELED 220
AP QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+
Sbjct: 312 QAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELEN 371
Query: 221 TNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVA 280
NKWGL++F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VA
Sbjct: 372 LNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVA 431
Query: 281 YHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSE 340
YHNSLHAADV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSE
Sbjct: 432 YHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSE 491
Query: 341 LALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMN 400
LALMYND SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM
Sbjct: 492 LALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMT 551
Query: 401 LLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMA 460
LLADLKTMVETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMA
Sbjct: 552 LLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMA 611
Query: 461 EFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDT 520
EFFQQGDRERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDT
Sbjct: 612 EFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDT 671
Query: 521 LEDNREWYQSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETA 574
LEDNR+WY S I +SPS E G PD+FQFELTL EEE+EEE +
Sbjct: 672 LEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPC 728
Query: 575 LAKEAL 580
A+EAL
Sbjct: 729 TAQEAL 734
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 826 bits (2134), Expect = 0.0
Identities = 420/589 (71%), Positives = 491/589 (83%), Gaps = 10/589 (1%)
Query: 7 HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAAL 66
HSQRRESFLYRSDSDY+LSPKAMSRNSS+ S+ HG+D+IVTPFAQVLASLR+VR+N L
Sbjct: 127 HSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTIL 186
Query: 67 ARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEM 126
+ K+ P + +++ P E++ QKLA+ETL+ELDWCLDQLET+QT SV EM
Sbjct: 187 TNLHGT-SNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEM 245
Query: 127 ASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPM 181
ASNKFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M
Sbjct: 246 ASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLM 305
Query: 182 SRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLT 241
++ISG+ L HS+SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT
Sbjct: 306 TQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLT 365
Query: 242 AIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATP 301
I+++IFQERDLLKTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TP
Sbjct: 366 CIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP 425
Query: 302 ALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 361
AL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFK
Sbjct: 426 ALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFK 485
Query: 362 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 421
LLQ E+CDIF NL+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLL
Sbjct: 486 LLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLL 545
Query: 422 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 481
LDNY+DRIQVL+N+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCD
Sbjct: 546 LDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCD 605
Query: 482 KHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---D 538
KHTASVEKSQVGFIDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D
Sbjct: 606 KHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLD 665
Query: 539 LTNPERDG-PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 586
N + G ++FQFELTL+E + E E+E EG + + L + D E
Sbjct: 666 EQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 714
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 826 bits (2134), Expect = 0.0
Identities = 420/589 (71%), Positives = 491/589 (83%), Gaps = 10/589 (1%)
Query: 7 HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAAL 66
HSQRRESFLYRSDSDY+LSPKAMSRNSS+ S+ HG+D+IVTPFAQVLASLR+VR+N L
Sbjct: 112 HSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTIL 171
Query: 67 ARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEM 126
+ K+ P + +++ P E++ QKLA+ETL+ELDWCLDQLET+QT SV EM
Sbjct: 172 TNLHGT-SNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEM 230
Query: 127 ASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPM 181
ASNKFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M
Sbjct: 231 ASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLM 290
Query: 182 SRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLT 241
++ISG+ L HS+SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT
Sbjct: 291 TQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLT 350
Query: 242 AIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATP 301
I+++IFQERDLLKTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TP
Sbjct: 351 CIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP 410
Query: 302 ALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 361
AL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFK
Sbjct: 411 ALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFK 470
Query: 362 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 421
LLQ E+CDIF NL+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLL
Sbjct: 471 LLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLL 530
Query: 422 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 481
LDNY+DRIQVL+N+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCD
Sbjct: 531 LDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCD 590
Query: 482 KHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---D 538
KHTASVEKSQVGFIDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D
Sbjct: 591 KHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLD 650
Query: 539 LTNPERDG-PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 586
N + G ++FQFELTL+E + E E+E EG + + L + D E
Sbjct: 651 EQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 699
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 826 bits (2134), Expect = 0.0
Identities = 420/589 (71%), Positives = 491/589 (83%), Gaps = 10/589 (1%)
Query: 7 HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAAL 66
HSQRRESFLYRSDSDY+LSPKAMSRNSS+ S+ HG+D+IVTPFAQVLASLR+VR+N L
Sbjct: 127 HSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTIL 186
Query: 67 ARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEM 126
+ K+ P + +++ P E++ QKLA+ETL+ELDWCLDQLET+QT SV EM
Sbjct: 187 TNLHGT-SNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEM 245
Query: 127 ASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPM 181
ASNKFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M
Sbjct: 246 ASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLM 305
Query: 182 SRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLT 241
++ISG+ L HS+SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT
Sbjct: 306 TQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLT 365
Query: 242 AIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATP 301
I+++IFQERDLLKTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TP
Sbjct: 366 CIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP 425
Query: 302 ALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 361
AL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFK
Sbjct: 426 ALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFK 485
Query: 362 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 421
LLQ E+CDIF NL+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLL
Sbjct: 486 LLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLL 545
Query: 422 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 481
LDNY+DRIQVL+N+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCD
Sbjct: 546 LDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCD 605
Query: 482 KHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---D 538
KHTASVEKSQVGFIDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D
Sbjct: 606 KHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLD 665
Query: 539 LTNPERDG-PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 586
N + G ++FQFELTL+E + E E+E EG + + L + D E
Sbjct: 666 EQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 714
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 735 bits (1897), Expect = 0.0
Identities = 373/516 (72%), Positives = 432/516 (83%), Gaps = 12/516 (2%)
Query: 83 PSSSNQLPP---AEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNREL 139
P N +P AE++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNREL
Sbjct: 27 PLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNREL 86
Query: 140 THLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSA 194
THLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+
Sbjct: 87 THLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSS 146
Query: 195 SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL 254
SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLL
Sbjct: 147 SLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLL 206
Query: 255 KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA 314
KTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILA
Sbjct: 207 KTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILA 266
Query: 315 ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL 374
A+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL
Sbjct: 267 AIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNL 326
Query: 375 SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN 434
+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N
Sbjct: 327 TKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRN 386
Query: 435 LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF 494
+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGF
Sbjct: 387 MVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGF 446
Query: 495 IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRF 550
IDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++F
Sbjct: 447 IDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKF 506
Query: 551 QFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 586
QFELTL+E + E E+E EG + + L + D E
Sbjct: 507 QFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 542
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 688 bits (1775), Expect = 0.0
Identities = 354/478 (74%), Positives = 397/478 (83%), Gaps = 29/478 (6%)
Query: 129 NKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEE-----AP----- 178
++FKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q EVE+P T +E AP
Sbjct: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
Query: 179 ----------QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDV 228
QPMS+I+GL L HS SL+++ +PRFGV+TDQEE LA+ELE+ NKWGL++
Sbjct: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Query: 229 FKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAA 288
F V++ +G R LT I++ IFQERDLLK F+IP DT+ TY+L LE HYHA+VAYHNSLHAA
Sbjct: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
Query: 289 DVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDA 348
DV QSTHVLLATPAL+AVFTDLEILAALFA+AIHDVDHPGVSNQFLINTNSELALMYND
Sbjct: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
Query: 349 SVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTM 408
SVLENHHLAVGFKLLQ +NCDIFQNLS +QR SLR+MVIDMVLATDMSKHM LLADLKTM
Sbjct: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
Query: 409 VETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDR 468
VETKKVTS GVLLLDNYSDRIQVL+N+VHCADLSNPTKPL LYRQWTDRIMAEFFQQGDR
Sbjct: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
Query: 469 ERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWY 528
ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLVHPDAQ++LDTLEDNR+WY
Sbjct: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
Query: 529 QSKIPRSPSDLTNPERDG------PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 580
S I +SPS E G PD+FQFELTL EEE+EEE + A+EAL
Sbjct: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTL---EEEEEEEISMAQIPCTAQEAL 495
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 238 bits (607), Expect = 1e-62
Identities = 134/383 (34%), Positives = 213/383 (55%), Gaps = 16/383 (4%)
Query: 218 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLE-GHYH 276
L++ + W DVF + + + + L I+F + +L+ F+IP L ++L LE G+
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 277 ANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLIN 336
YHN +HAADV Q+ H L + +++E+LA +FA+AIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 337 TNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMS 396
T SE A++YND SVLENHH++ F+L+Q + +IF NL+ + + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 397 KHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTD 456
H + +KT ++ + D+ + L L+H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 457 RIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQD 516
+M EFF+QGD+E E GL SP+CD+ + V +SQ+GFID+I P + D+ Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 517 LLDTLEDNREWYQSKIP-RSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETAL 575
L D ED++ Q R PS PD F T + +E++++ +E + +
Sbjct: 447 LAD--EDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGI 504
Query: 576 AKEALELPDTELLSPEAGPDPGD 598
+ + + + EA P P +
Sbjct: 505 TNQ-MSIDELSPCEEEAPPSPAE 526
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 234 bits (596), Expect = 2e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 144 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 203
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
Query: 204 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 263
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
Query: 264 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 322
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
Query: 323 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 382
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
Query: 383 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 442
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
Query: 443 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 502
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
Query: 503 WETWAD 508
+ D
Sbjct: 429 FSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 234 bits (596), Expect = 2e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 144 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 203
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
Query: 204 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 263
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
Query: 264 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 322
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
Query: 323 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 382
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
Query: 383 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 442
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
Query: 443 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 502
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
Query: 503 WETWAD 508
+ D
Sbjct: 429 FSLLTD 434
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 229 bits (585), Expect = 4e-60
Identities = 123/305 (40%), Positives = 178/305 (58%), Gaps = 15/305 (4%)
Query: 218 LEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHY-- 275
L+D +KW DVF + E SG+ L I + + DL+ F+IP L +++ LE Y
Sbjct: 163 LKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSK 222
Query: 276 HANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLI 335
H N YHN +HAADV Q+ H LL + T+LEI A +F++AIHD +H G +N F I
Sbjct: 223 HKN-PYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHI 281
Query: 336 NTNSELALMYNDASVLENHHLAVGFKLLQ-AENCDIFQNLSAKQRLSLRRMVIDMVLATD 394
T S+ A++YND SVLENHHL+ ++LLQ E +I NLS R +VI+MV+ATD
Sbjct: 282 QTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATD 341
Query: 395 MSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQW 454
MS H + +KT ++ + ++ + L ++H AD+S+P K L+ +W
Sbjct: 342 MSCHFQQIKAMKTALQQPEAI-----------EKPKALSLMLHTADISHPAKAWDLHHRW 390
Query: 455 TDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDA 514
T ++ EFF+QGDRE E GL SP+CD+ + V +SQVGFID+I P + D+
Sbjct: 391 TMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIV 450
Query: 515 QDLLD 519
L+D
Sbjct: 451 SPLID 455
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 224 bits (570), Expect = 2e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 209 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 437 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 496
Query: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 328
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 497 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 556
Query: 329 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 387
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 557 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 616
Query: 388 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 436
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 617 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 676
Query: 437 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 495
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 677 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 736
Query: 496 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 529
DY +++ W V D DL+ L++N ++++
Sbjct: 737 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 768
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 224 bits (570), Expect = 2e-58
Identities = 119/334 (35%), Positives = 194/334 (58%), Gaps = 15/334 (4%)
Query: 209 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
D ++A+ +E+ W D+F++ + NRPL + +F + + TL ++L
Sbjct: 483 DVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWL 542
Query: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 328
++E +YH++ YHNS H+ADV +T L+ ++ ++ +AAL A+ IHDVDHPG
Sbjct: 543 QIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPG 602
Query: 329 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAEN-CDIFQNLSAKQRLSLRRMVI 387
+N FL N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +I
Sbjct: 603 RTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGII 662
Query: 388 DMVLATDMSKHM-----------NLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLV 436
DMVLAT+M+KH LA L+ ET K + +L +R + + L+
Sbjct: 663 DMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLI 722
Query: 437 HCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFI 495
CAD+SNP +PL +W RI E+F Q D E++ GL + P+ D++T S+ KSQ+ FI
Sbjct: 723 KCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFI 782
Query: 496 DYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 529
DY +++ W V D DL+ L++N ++++
Sbjct: 783 DYFITDMFDAWDAFV--DLPDLMQHLDNNFKYWK 814
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 213 bits (542), Expect = 4e-55
Identities = 122/396 (30%), Positives = 204/396 (51%), Gaps = 21/396 (5%)
Query: 181 MSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKE---LEDTNKWGLDVFKVAELSGN 237
+ R+ H++ L +P+ + E+ L + L W D+F L+
Sbjct: 69 VKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNG 128
Query: 238 RPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVL 297
L ++ +F L+ F++ TL +L+M++ YH+ YHN++HAADV Q+ H
Sbjct: 129 NSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCY 188
Query: 298 LATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLA 357
L P L + T L+I+ L A+A HDVDHPGV+ FLI TN LA +Y + SVLENHH
Sbjct: 189 LKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWR 248
Query: 358 VGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSL 417
+L+ + +L + + + + ++LATD+++ L LK + K
Sbjct: 249 STIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKD---- 302
Query: 418 GVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDIS 477
L L++ DR +LQ + CAD+ NP + + +QW++R+ EF++QG+ E++ L+IS
Sbjct: 303 --LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS 360
Query: 478 PMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPD--AQDLLDTLEDNREWYQSKIPRS 535
P+C++ S+ Q+GF+ YI PL+ WA ++++L L N+ ++S +PR
Sbjct: 361 PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ 420
Query: 536 PSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGE 571
GPD + A + E EE+EG+
Sbjct: 421 HRS-RGSSGSGPDH-------DHAGQGTESEEQEGD 448
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 209 bits (532), Expect = 6e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 214 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 273
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
Query: 274 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 333
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
Query: 334 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 392
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
Query: 393 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 445
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 739
Query: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 504
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 740 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 799
Query: 505 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 538
W H A L+ L DN + W + K R PSD
Sbjct: 800 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 837
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 209 bits (532), Expect = 6e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 214 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 273
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 527 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586
Query: 274 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 333
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 646
Query: 334 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 392
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 647 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 706
Query: 393 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 445
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 707 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 766
Query: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 504
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 767 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 826
Query: 505 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 538
W H A L+ L DN + W + K R PSD
Sbjct: 827 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 864
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 209 bits (532), Expect = 6e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 214 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 273
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 492 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551
Query: 274 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 333
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 611
Query: 334 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 392
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 612 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 671
Query: 393 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 445
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 672 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 731
Query: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 504
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 732 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 791
Query: 505 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 538
W H A L+ L DN + W + K R PSD
Sbjct: 792 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 829
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 209 bits (532), Expect = 6e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 214 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 273
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 450 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509
Query: 274 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 333
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 569
Query: 334 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 392
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 570 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 629
Query: 393 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 445
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 630 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 689
Query: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 504
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 690 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 749
Query: 505 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 538
W H A L+ L DN + W + K R PSD
Sbjct: 750 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 787
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 209 bits (532), Expect = 6e-54
Identities = 115/340 (33%), Positives = 189/340 (55%), Gaps = 17/340 (5%)
Query: 214 LAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEG 273
+++ L++ W ++F++ ++ RPL + +F + + TL + ++E
Sbjct: 547 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606
Query: 274 HYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQF 333
+YH++ AYHNS HAADV +T L ++ L+ +AAL A+ +HDVDHPG +N F
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 666
Query: 334 LINTNSELALMYNDASVLENHHLAVGFKL-LQAENCDIFQNLSAKQRLSLRRMVIDMVLA 392
L N SELA++YND +VLE+HH A+ F+L ++ C+IF+N+ +LR+ +IDMVLA
Sbjct: 667 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 726
Query: 393 TDMSKHMNLLADLKTMVETKKVTSLGVLLLD------NY-SDRIQVLQNLVHCADLSNPT 445
T+M+KH + + + + N+ ++I + + ++ CAD++NP
Sbjct: 727 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPC 786
Query: 446 KPLPLYRQWTDRIMAEFFQQGDRERESGLD-ISPMCDKHTASVEKSQVGFIDYIAHPLWE 504
+PL L +W RI E+F Q D E+ GL + P+ D++T S+ KSQ+ FIDY +++
Sbjct: 787 RPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFD 846
Query: 505 TWADLVHPDAQDLLDTLEDN-REW-----YQSKIPRSPSD 538
W H A L+ L DN + W + K R PSD
Sbjct: 847 AWDAFAHLPA--LMQHLADNYKHWKTLDDLKCKSLRLPSD 884
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 208 bits (529), Expect = 1e-53
Identities = 108/299 (36%), Positives = 166/299 (55%), Gaps = 8/299 (2%)
Query: 209 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 113 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 172
Query: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 328
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 173 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 232
Query: 329 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 388
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 233 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 290
Query: 389 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 448
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 291 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 344
Query: 449 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWA 507
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+GF+ Y+ PL+ WA
Sbjct: 345 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 194 bits (493), Expect = 2e-49
Identities = 103/290 (35%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 209 DQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYL 268
D Q LE W D+F L+ L ++ F +F L++ F + L +L
Sbjct: 139 DYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFL 198
Query: 269 LMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPG 328
+M++ YH+ YHN++HAADV Q+ H L P L T +IL +L A+A HD+DHPG
Sbjct: 199 VMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPG 258
Query: 329 VSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVID 388
V+ FLI TN LA +Y + SVLENHH LL+ +F +L + R + +
Sbjct: 259 VNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESG--LFSHLPLESRQQMETQIGA 316
Query: 389 MVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPL 448
++LATD+S+ L+ ++ ++ G L L++ R VLQ + CAD+ NP +
Sbjct: 317 LILATDISRQNEYLSLFRSHLDR------GDLCLEDTRHRHLVLQMALKCADICNPCRTW 370
Query: 449 PLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 498
L +QW++++ EFF QGD E++ L +SP+CD+HT S+ Q+G Y+
Sbjct: 371 ELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGNYTYL 420
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 171 bits (432), Expect = 2e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 247 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 306
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 129
Query: 307 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 366
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 130 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 189
Query: 367 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 426
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 243
Query: 427 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 486
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 244 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 301
Query: 487 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 529
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 302 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 344
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 171 bits (432), Expect = 2e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 247 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 306
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 71 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 129
Query: 307 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 366
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 130 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 189
Query: 367 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 426
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 190 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 243
Query: 427 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 486
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 244 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 301
Query: 487 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 529
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 302 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 344
>gi|48762750 phosphodiesterase 9A isoform o [Homo sapiens]
Length = 567
Score = 171 bits (432), Expect = 2e-42
Identities = 88/283 (31%), Positives = 158/283 (55%), Gaps = 9/283 (3%)
Query: 247 IFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAV 306
++ + L++ F I TL +L + +Y N +HN H VAQ + ++ +L+
Sbjct: 252 MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCFCVAQMMYSMVWLCSLQEK 310
Query: 307 FTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAE 366
F+ +IL + A+ HD+DHPG +N + IN +ELA+ YND S LENHH AV F++L
Sbjct: 311 FSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEP 370
Query: 367 NCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYS 426
C+IF N+ +R+ +I ++LATDM++H ++ K +E ++ + +
Sbjct: 371 ECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSN------EEHM 424
Query: 427 DRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTAS 486
++++ L+ C D+SN +P+ + W D ++ E+F Q DRE+ GL ++P D+ +
Sbjct: 425 TLLKMI--LIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVT 482
Query: 487 VEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQ 529
+Q+GFI ++ P++ET L + +L L ++R+ Y+
Sbjct: 483 KATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYE 525
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,523,857
Number of Sequences: 37866
Number of extensions: 1017218
Number of successful extensions: 11963
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 8528
Number of HSP's gapped (non-prelim): 1606
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.