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Search of human proteins with 149274651
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|149274651 centrosomal protein 78kDa isoform b [Homo sapiens]
(706 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|149274651 centrosomal protein 78kDa isoform b [Homo sapiens] 1405 0.0
gi|149274621 centrosomal protein 78kDa isoform a [Homo sapiens] 1395 0.0
gi|118918429 NOD3 protein [Homo sapiens] 69 2e-11
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 56 1e-07
gi|5174617 nucleotide-binding oligomerization domain containing ... 56 1e-07
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 55 3e-07
gi|23503285 leucine rich repeat containing 34 [Homo sapiens] 55 3e-07
gi|11545912 nucleotide-binding oligomerization domain containing... 54 6e-07
gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ... 52 2e-06
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ... 52 2e-06
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ... 52 2e-06
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 52 2e-06
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 50 5e-06
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 50 5e-06
gi|61175232 hypothetical protein LOC221424 [Homo sapiens] 50 9e-06
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 49 1e-05
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 48 4e-05
gi|113205085 leucine rich repeat containing 31 [Homo sapiens] 48 4e-05
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 6e-05
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 6e-05
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 6e-05
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 6e-05
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 6e-05
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 6e-05
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 6e-05
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 6e-05
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 46 1e-04
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 46 1e-04
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 45 2e-04
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 45 3e-04
>gi|149274651 centrosomal protein 78kDa isoform b [Homo sapiens]
Length = 706
Score = 1405 bits (3638), Expect = 0.0
Identities = 706/706 (100%), Positives = 706/706 (100%)
Query: 1 MIDSVKLRRDSAADFFSHYEYLCALQNSVPLPAVRACLREGVLDFNADRLRGVDWAPLLS 60
MIDSVKLRRDSAADFFSHYEYLCALQNSVPLPAVRACLREGVLDFNADRLRGVDWAPLLS
Sbjct: 1 MIDSVKLRRDSAADFFSHYEYLCALQNSVPLPAVRACLREGVLDFNADRLRGVDWAPLLS 60
Query: 61 TLKINKDLPLVSIKSFFQPWLGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISS 120
TLKINKDLPLVSIKSFFQPWLGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISS
Sbjct: 61 TLKINKDLPLVSIKSFFQPWLGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISS 120
Query: 121 VLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKT 180
VLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKT
Sbjct: 121 VLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKT 180
Query: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI 240
VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI
Sbjct: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI 240
Query: 241 GDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHS 300
GDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHS
Sbjct: 241 GDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHS 300
Query: 301 MMKAVIKKVLQNGRSAKSEYQWITSPSVKEPSKTAKQKRRTIILGSGHKGKATIRIVGLA 360
MMKAVIKKVLQNGRSAKSEYQWITSPSVKEPSKTAKQKRRTIILGSGHKGKATIRIVGLA
Sbjct: 301 MMKAVIKKVLQNGRSAKSEYQWITSPSVKEPSKTAKQKRRTIILGSGHKGKATIRIVGLA 360
Query: 361 TKKPVSSGRKHSLGKEYYAPAPLPPGVSGFLPWRTAERAKRHRGFPLIKTRDICNQLQQP 420
TKKPVSSGRKHSLGKEYYAPAPLPPGVSGFLPWRTAERAKRHRGFPLIKTRDICNQLQQP
Sbjct: 361 TKKPVSSGRKHSLGKEYYAPAPLPPGVSGFLPWRTAERAKRHRGFPLIKTRDICNQLQQP 420
Query: 421 GFPVTVTVESPSSSEVEEVDDSSESVHEVPEKTSIEQEALQEKLEECLKQLKEERVIRLK 480
GFPVTVTVESPSSSEVEEVDDSSESVHEVPEKTSIEQEALQEKLEECLKQLKEERVIRLK
Sbjct: 421 GFPVTVTVESPSSSEVEEVDDSSESVHEVPEKTSIEQEALQEKLEECLKQLKEERVIRLK 480
Query: 481 VDKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLK 540
VDKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLK
Sbjct: 481 VDKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLK 540
Query: 541 DAGLGQLATMAGIDQSDFQLLGHPQMTSTVSNPPKEEKKALEDEKPEPKQNALGQMQNIQ 600
DAGLGQLATMAGIDQSDFQLLGHPQMTSTVSNPPKEEKKALEDEKPEPKQNALGQMQNIQ
Sbjct: 541 DAGLGQLATMAGIDQSDFQLLGHPQMTSTVSNPPKEEKKALEDEKPEPKQNALGQMQNIQ 600
Query: 601 FQKITGDARIPLPLDSFPVPVSTPEGLGTSSNNLGVPATEQRQESFEGFIARMCSPSPDA 660
FQKITGDARIPLPLDSFPVPVSTPEGLGTSSNNLGVPATEQRQESFEGFIARMCSPSPDA
Sbjct: 601 FQKITGDARIPLPLDSFPVPVSTPEGLGTSSNNLGVPATEQRQESFEGFIARMCSPSPDA 660
Query: 661 TSGTGSQRKEEELSRNSRSSSEKKTKTGEYTKKHSDKQHPGKDLHS 706
TSGTGSQRKEEELSRNSRSSSEKKTKTGEYTKKHSDKQHPGKDLHS
Sbjct: 661 TSGTGSQRKEEELSRNSRSSSEKKTKTGEYTKKHSDKQHPGKDLHS 706
>gi|149274621 centrosomal protein 78kDa isoform a [Homo sapiens]
Length = 722
Score = 1395 bits (3611), Expect = 0.0
Identities = 706/722 (97%), Positives = 706/722 (97%), Gaps = 16/722 (2%)
Query: 1 MIDSVKLRRDSAADFFSHYEYLCALQNSVPLPAVRACLREGVLDFNADRLRGVDWAPLLS 60
MIDSVKLRRDSAADFFSHYEYLCALQNSVPLPAVRACLREGVLDFNADRLRGVDWAPLLS
Sbjct: 1 MIDSVKLRRDSAADFFSHYEYLCALQNSVPLPAVRACLREGVLDFNADRLRGVDWAPLLS 60
Query: 61 TLKINKDLPLVSIKSFFQPWLGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISS 120
TLKINKDLPLVSIKSFFQPWLGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISS
Sbjct: 61 TLKINKDLPLVSIKSFFQPWLGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISS 120
Query: 121 VLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKT 180
VLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKT
Sbjct: 121 VLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKT 180
Query: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI 240
VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI
Sbjct: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI 240
Query: 241 GDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHS 300
GDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHS
Sbjct: 241 GDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHS 300
Query: 301 MMKAVIKKVLQNGRSAKSEYQWITSPSVKEPSKTAKQKRRTIILGSGHKGKATIRIVGLA 360
MMKAVIKKVLQNGRSAKSEYQWITSPSVKEPSKTAKQKRRTIILGSGHKGKATIRIVGLA
Sbjct: 301 MMKAVIKKVLQNGRSAKSEYQWITSPSVKEPSKTAKQKRRTIILGSGHKGKATIRIVGLA 360
Query: 361 TKKPVSSGRKHSLGKEYYAPAPLPPGVSGFLPWRTAERAKRHRGFPLIKTRDICNQLQQP 420
TKKPVSSGRKHSLGKEYYAPAPLPPGVSGFLPWRTAERAKRHRGFPLIKTRDICNQLQQP
Sbjct: 361 TKKPVSSGRKHSLGKEYYAPAPLPPGVSGFLPWRTAERAKRHRGFPLIKTRDICNQLQQP 420
Query: 421 GFPVTVTVESPSSSEVEEVDDSSESVHEVPEKTSIEQEALQEKLEECLKQLKEERVIRLK 480
GFPVTVTVESPSSSEVEEVDDSSESVHEVPEKTSIEQEALQEKLEECLKQLKEERVIRLK
Sbjct: 421 GFPVTVTVESPSSSEVEEVDDSSESVHEVPEKTSIEQEALQEKLEECLKQLKEERVIRLK 480
Query: 481 VDKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLK 540
VDKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLK
Sbjct: 481 VDKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLK 540
Query: 541 DAGLGQLATMAGIDQSDFQLLGHPQMTSTVSNPPKEEKKALEDEKPEPKQNALGQMQNIQ 600
DAGLGQLATMAGIDQSDFQLLGHPQMTSTVSNPPKEEKKALEDEKPEPKQNALGQMQNIQ
Sbjct: 541 DAGLGQLATMAGIDQSDFQLLGHPQMTSTVSNPPKEEKKALEDEKPEPKQNALGQMQNIQ 600
Query: 601 ----------------FQKITGDARIPLPLDSFPVPVSTPEGLGTSSNNLGVPATEQRQE 644
FQKITGDARIPLPLDSFPVPVSTPEGLGTSSNNLGVPATEQRQE
Sbjct: 601 VSICMQSAYNEGTLMKFQKITGDARIPLPLDSFPVPVSTPEGLGTSSNNLGVPATEQRQE 660
Query: 645 SFEGFIARMCSPSPDATSGTGSQRKEEELSRNSRSSSEKKTKTGEYTKKHSDKQHPGKDL 704
SFEGFIARMCSPSPDATSGTGSQRKEEELSRNSRSSSEKKTKTGEYTKKHSDKQHPGKDL
Sbjct: 661 SFEGFIARMCSPSPDATSGTGSQRKEEELSRNSRSSSEKKTKTGEYTKKHSDKQHPGKDL 720
Query: 705 HS 706
HS
Sbjct: 721 HS 722
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 68.6 bits (166), Expect = 2e-11
Identities = 62/238 (26%), Positives = 105/238 (44%), Gaps = 7/238 (2%)
Query: 90 KFCRSRVPAIRYKDVTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSAS 149
K CR + ++ ++ + KAL L ++ L +L+L G + + LA L + +
Sbjct: 664 KDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRT 723
Query: 150 LVHLSLANCPIGDGGLEIICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHE 209
L LSL + D G + + + S+ TL ++ ++ GA MA LK +
Sbjct: 724 LTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKEL 783
Query: 210 ETWAESL-----RYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQ 264
+ S+ + L GL + L N+ I D G A +L + L +L L+
Sbjct: 784 MFSSNSIGDGGAKALAEALKVNQGLESLDLQSNS-ISDAGVAALMGALCTNQTLLSLSLR 842
Query: 265 QCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKSEYQW 322
+ ++ EGA+A+ AL N+TL LD+ N L D +A+ V +N QW
Sbjct: 843 ENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQG-ARAIAVAVRENRTLTSLHLQW 899
Score = 66.6 bits (161), Expect = 7e-11
Identities = 59/192 (30%), Positives = 91/192 (47%), Gaps = 6/192 (3%)
Query: 110 KALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIIC 169
KAL L ++ L++L+L + + + L L + +L+ LSL I G + I
Sbjct: 796 KALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIA 855
Query: 170 QGIKSSITLKTVNFTGCNLTWQGADHMA-KILKYQTMRRHEETW----AESLRYRRPDLD 224
+ ++ TLK ++ T L QGA +A + + +T+ W A + + L
Sbjct: 856 HALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQ 915
Query: 225 CMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNT 284
L + L N IGD GACA A +L + L AL LQ + GA+ L EAL N
Sbjct: 916 LNRSLTSLDLQENA-IGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNR 974
Query: 285 TLVVLDIRKNPL 296
TL +LD+R N +
Sbjct: 975 TLEILDLRGNAI 986
Score = 51.6 bits (122), Expect = 2e-06
Identities = 58/216 (26%), Positives = 94/216 (43%), Gaps = 41/216 (18%)
Query: 91 FCRS-RVPAIRYKDVTFQLCKALKGCLSISSVL--KNLELNGLILRERDLT-----ILAK 142
+CR R+ +++D +L + SVL K+ + + L E ++ LA+
Sbjct: 638 YCRKLRLDTNQFQDPVMEL---------LGSVLSGKDCRIQKISLAENQISNKGAKALAR 688
Query: 143 GLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKY 202
L + SL L L IG G + + +K + TL +++ G + GA MA
Sbjct: 689 SLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMA----- 743
Query: 203 QTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALD 262
E+L R L + L N+ IG +GA AD+L ++ L+ L
Sbjct: 744 -----------EALASNRT-------LSMLHLQKNS-IGPMGAQRMADALKQNRSLKELM 784
Query: 263 LQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ + GAKAL EAL+ N L LD++ N + D
Sbjct: 785 FSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISD 820
Score = 49.3 bits (116), Expect = 1e-05
Identities = 60/251 (23%), Positives = 113/251 (45%), Gaps = 14/251 (5%)
Query: 58 LLSTLKINKDLPLVSIKSFFQPWLGDTG--SDMNKFCRSRVP---AIRYKDVTFQLCKAL 112
L LK+N+ L + ++S + D G + M C ++ ++R ++ + +A+
Sbjct: 798 LAEALKVNQGLESLDLQSNS---ISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAI 854
Query: 113 KGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGI 172
L +S LKNL+L +L ++ +A + ++ +L L L I G + + Q +
Sbjct: 855 AHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQAL 914
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMR-----RHEETWAESLRYRRPDLDCMA 227
+ + +L +++ + GA +A+ LK T + A + L
Sbjct: 915 QLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNR 974
Query: 228 GLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLV 287
L + L N IG GA A A++L + LR L+LQ+ L +GA + AL N L
Sbjct: 975 TLEILDLRGNA-IGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQ 1033
Query: 288 VLDIRKNPLID 298
++++ N + D
Sbjct: 1034 HINLQGNHIGD 1044
Score = 46.6 bits (109), Expect = 8e-05
Identities = 43/182 (23%), Positives = 82/182 (45%), Gaps = 24/182 (13%)
Query: 110 KALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIIC 169
+AL L ++ L +L+L + + +A+ L + +L L L IG G +++
Sbjct: 908 QALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLG 967
Query: 170 QGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGL 229
+ + + TL+ ++ G + GA +A LK + L
Sbjct: 968 EALAVNRTLEILDLRGNAIGVAGAKALANALKVNS-----------------------SL 1004
Query: 230 RRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
RR+ L N+L D GA A +LS + L+ ++LQ + + GA+ + EA++TN +
Sbjct: 1005 RRLNLQENSLGMD-GAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTNAPTCTV 1063
Query: 290 DI 291
++
Sbjct: 1064 EM 1065
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/178 (29%), Positives = 78/178 (43%), Gaps = 28/178 (15%)
Query: 122 LKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIK-SSITLKT 180
L+ L L L E + LA L S L HL LA PIG+ G++ +C+G++ L+T
Sbjct: 842 LQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQT 901
Query: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCM-AGLRRITLNCNTL 239
+ C++T G + K+L+ + L C+ GL
Sbjct: 902 LVLWNCDITSDGCCDLTKLLQ-----------------EKSSLLCLDLGLNH-------- 936
Query: 240 IGDLGACAFADSLSEDLW-LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
IG G ++L + L LR L L C + + L AL N +LV LD+ +NPL
Sbjct: 937 IGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPL 994
Score = 33.1 bits (74), Expect = 0.91
Identities = 35/152 (23%), Positives = 65/152 (42%), Gaps = 6/152 (3%)
Query: 223 LDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALET 282
L+ L + L+ N L+ + + +L+ L L+ C LT K L L
Sbjct: 807 LEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVV 866
Query: 283 NTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKSEYQW---ITSPSVKEPSKTAKQKR 339
+ L L + KNP I ++ +K + + + ++ W ITS + +K ++K
Sbjct: 867 SRELTHLCLAKNP-IGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKS 925
Query: 340 RTII--LGSGHKGKATIRIVGLATKKPVSSGR 369
+ LG H G ++ + A +KP+ + R
Sbjct: 926 SLLCLDLGLNHIGVKGMKFLCEALRKPLCNLR 957
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 55.8 bits (133), Expect = 1e-07
Identities = 77/302 (25%), Positives = 129/302 (42%), Gaps = 34/302 (11%)
Query: 21 YLCALQNSVPLPAVRACLREGVLDFNADRLRGVDWAPLLSTLK-INKDLPLVSIKSFFQP 79
+LC L + +R + L R R WA L S+L+ K LP V ++SF Q
Sbjct: 591 FLCGLLSKAKQKLLRHLVPAAALR----RKRKALWAHLFSSLRGYLKSLPRVQVESFNQV 646
Query: 80 -------WL----GDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKG-CLSISSVLKN--- 124
W+ +T S +R Y +T+ C A C ++S VL +
Sbjct: 647 QAMPTFIWMLRCIYETQSQKVGQLAARGICANYLKLTY--CNACSADCSALSFVLHHFPK 704
Query: 125 ---LELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKTV 181
L+L+ L + + L ++ L L L+ I DGG++++ + + + +
Sbjct: 705 RLALDLDNNNLNDYGVRELQPCFSR---LTVLRLSVNQITDGGVKVLSEELTKYKIVTYL 761
Query: 182 NFTGCNLTWQGADHMAKILKYQTMRRH-----EETWAESLRYRRPDLDCMAGLRRITLNC 236
+T GA ++ KIL H + +E +Y + + + +
Sbjct: 762 GLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWG 821
Query: 237 NTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
N +GD GA AFA++L L L L G++ EG K+L AL+ NT+L +L + +N L
Sbjct: 822 NQ-VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNEL 880
Query: 297 ID 298
D
Sbjct: 881 ND 882
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 54.7 bits (130), Expect = 3e-07
Identities = 51/184 (27%), Positives = 84/184 (45%), Gaps = 26/184 (14%)
Query: 122 LKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKT 180
L+ L LN L LA L ++ L HLSL+ P+ D G++++C+ ++ S L+
Sbjct: 982 LQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQD 1041
Query: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI 240
+ C+LT + ++ ++ + RH L+ + L N L
Sbjct: 1042 LELVKCHLTAACCESLSCVI---SRSRH--------------------LKSLDLTDNAL- 1077
Query: 241 GDLGACAFADSLSE-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDH 299
GD G A + L + + L L L+ CGLT++ +AL AL N L L++ +N
Sbjct: 1078 GDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPK 1137
Query: 300 SMMK 303
MMK
Sbjct: 1138 GMMK 1141
Score = 42.7 bits (99), Expect = 0.001
Identities = 50/194 (25%), Positives = 85/194 (43%), Gaps = 32/194 (16%)
Query: 122 LKNLELNGLILRERDL-TILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKT 180
L+ L+L IL ER + T+ AK + + + L N I G ++ + + + ++ L++
Sbjct: 783 LRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPG-VQHLWRIVMANRNLRS 841
Query: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMA------------- 227
+N G +L + + LK H + ESLR LDC
Sbjct: 842 LNLGGTHLKEEDVRMACEALK------HPKCLLESLR-----LDCCGLTHACYLKISQIL 890
Query: 228 ----GLRRITLNCNTLIGDLGACAFADSLS-EDLWLRALDLQQCGLTNEGAKALLEALET 282
L+ ++L N + D G +D+L L+ L L+ CG+T G ++L AL +
Sbjct: 891 TTSPSLKSLSLAGNK-VTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVS 949
Query: 283 NTTLVVLDIRKNPL 296
N +L L + N L
Sbjct: 950 NRSLTHLCLSNNSL 963
Score = 30.4 bits (67), Expect = 5.9
Identities = 23/90 (25%), Positives = 42/90 (46%), Gaps = 1/90 (1%)
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGL-NKSASLVHLSLANCPIGD 162
+T C++L +S S LK+L+L L + + L +GL K++ L L L C +
Sbjct: 1049 LTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
Query: 163 GGLEIICQGIKSSITLKTVNFTGCNLTWQG 192
E + + + L ++N N + +G
Sbjct: 1109 DCCEALSLALSCNRHLTSLNLVQNNFSPKG 1138
>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
Length = 419
Score = 54.7 bits (130), Expect = 3e-07
Identities = 58/219 (26%), Positives = 101/219 (46%), Gaps = 18/219 (8%)
Query: 108 LCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEI 167
L K LK CL I+ L++ +L + AK L K +L++L+L IG G E+
Sbjct: 102 LSKILKNCLYING----LDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGEL 157
Query: 168 ICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRH--------EETWAESLRYR 219
I + + + TLK + TG + +G A +L+ + EE+ R
Sbjct: 158 IAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEESTVHVGRML 217
Query: 220 RPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEA 279
+ + C+ L C I + G D+L + LR LD+ +T++G L +
Sbjct: 218 KEN-HCLVALHM----CKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADV 272
Query: 280 LETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKS 318
L++NTTL V+D+ N I+++ + + + + RS K+
Sbjct: 273 LKSNTTLEVIDLSFN-RIENAGANYLSETLTSHNRSLKA 310
Score = 38.9 bits (89), Expect = 0.017
Identities = 41/171 (23%), Positives = 78/171 (45%), Gaps = 26/171 (15%)
Query: 116 LSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSS 175
L I+S L+ L+L L E + + + L ++ LV L + I + G++ +C + +
Sbjct: 190 LQINSSLEKLDLGDCDLEESTVHV-GRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLN 248
Query: 176 ITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLN 235
+L+ ++ + +T G ++A +LK T L I L+
Sbjct: 249 SSLRYLDVSCNKITHDGMVYLADVLKSNTT-----------------------LEVIDLS 285
Query: 236 CNTLIGDLGACAFADSL-SEDLWLRALDLQQCGLTNEGAKALLEALETNTT 285
N I + GA +++L S + L+AL + + EG AL ++++TN T
Sbjct: 286 FNR-IENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLT 335
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 53.5 bits (127), Expect = 6e-07
Identities = 58/227 (25%), Positives = 102/227 (44%), Gaps = 20/227 (8%)
Query: 81 LGDTGSDMNKFCRSRVPAIRYKDVTFQ---LCKALKGCLSISSVLKNLELNGLILRERDL 137
+GD G + C A+ +D +CK ++ C L+ L L L +
Sbjct: 802 VGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIE-CALHCEQLQKLALFNNKLTDGCA 860
Query: 138 TILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKTVNFTGCNLTWQGADHMA 197
+AK L + + L L N I G +++ +G++ + +L+ + F G + +GA +A
Sbjct: 861 HSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALA 920
Query: 198 KIL-KYQTMRRHEETWAESLRYRRPDLDCMA---------GLRRITLNCNTLIGDLGACA 247
+ L +Q++R W + + A L + L N L D G C+
Sbjct: 921 EALGDHQSLR-----WLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHL-QDEGVCS 974
Query: 248 FADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKN 294
A+ L ++ L+ L L +T GA+ALL+ALE N T++ + +R N
Sbjct: 975 LAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGN 1021
Score = 32.7 bits (73), Expect = 1.2
Identities = 22/62 (35%), Positives = 32/62 (51%)
Query: 240 IGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDH 299
+GD GA A A++L + LR L L + + GA+AL L N L L + +N L D
Sbjct: 911 VGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDE 970
Query: 300 SM 301
+
Sbjct: 971 GV 972
Score = 31.6 bits (70), Expect = 2.6
Identities = 25/87 (28%), Positives = 45/87 (51%)
Query: 110 KALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIIC 169
+AL L+ + +L+ L L L++ + LA+GL K++SL L L+N I G E +
Sbjct: 945 QALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALL 1004
Query: 170 QGIKSSITLKTVNFTGCNLTWQGADHM 196
Q ++ + T+ V G + + D +
Sbjct: 1005 QALERNDTILEVWLRGNTFSLEEVDKL 1031
>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 52.0 bits (123), Expect = 2e-06
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 18/221 (8%)
Query: 108 LCKALKGCLSISSV-LKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLE 166
L ALK +++ + L + +LNGL +D L L + SL L L N + D GL
Sbjct: 252 LATALKMNMNLRELYLADNKLNGL----QDSAQLGNLLKFNCSLQILDLRNNHVLDSGLA 307
Query: 167 IICQGIKSSIT-LKTVNFTGCNLTWQGADHMAKILKY----QTMRR-HEETWAESLRYRR 220
IC+G+K L T+ LT G + L + +T+ H E +R+ +
Sbjct: 308 YICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLK 367
Query: 221 PDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEAL 280
L + R+ L L + GA A A+ ++E L LDL++ + G AL AL
Sbjct: 368 NGLISNRSVLRLGLASTKLTCE-GAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLAL 426
Query: 281 ETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKSEYQ 321
+ N +L+ LD+ + P K +K ++ ++ +E Q
Sbjct: 427 KVNHSLLRLDLDREP------KKEAVKSFIETQKALLAEIQ 461
>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 52.0 bits (123), Expect = 2e-06
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 18/221 (8%)
Query: 108 LCKALKGCLSISSV-LKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLE 166
L ALK +++ + L + +LNGL +D L L + SL L L N + D GL
Sbjct: 252 LATALKMNMNLRELYLADNKLNGL----QDSAQLGNLLKFNCSLQILDLRNNHVLDSGLA 307
Query: 167 IICQGIKSSIT-LKTVNFTGCNLTWQGADHMAKILKY----QTMRR-HEETWAESLRYRR 220
IC+G+K L T+ LT G + L + +T+ H E +R+ +
Sbjct: 308 YICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLK 367
Query: 221 PDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEAL 280
L + R+ L L + GA A A+ ++E L LDL++ + G AL AL
Sbjct: 368 NGLISNRSVLRLGLASTKLTCE-GAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLAL 426
Query: 281 ETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKSEYQ 321
+ N +L+ LD+ + P K +K ++ ++ +E Q
Sbjct: 427 KVNHSLLRLDLDREP------KKEAVKSFIETQKALLAEIQ 461
>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 52.0 bits (123), Expect = 2e-06
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 18/221 (8%)
Query: 108 LCKALKGCLSISSV-LKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLE 166
L ALK +++ + L + +LNGL +D L L + SL L L N + D GL
Sbjct: 252 LATALKMNMNLRELYLADNKLNGL----QDSAQLGNLLKFNCSLQILDLRNNHVLDSGLA 307
Query: 167 IICQGIKSSIT-LKTVNFTGCNLTWQGADHMAKILKY----QTMRR-HEETWAESLRYRR 220
IC+G+K L T+ LT G + L + +T+ H E +R+ +
Sbjct: 308 YICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLK 367
Query: 221 PDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEAL 280
L + R+ L L + GA A A+ ++E L LDL++ + G AL AL
Sbjct: 368 NGLISNRSVLRLGLASTKLTCE-GAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLAL 426
Query: 281 ETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKSEYQ 321
+ N +L+ LD+ + P K +K ++ ++ +E Q
Sbjct: 427 KVNHSLLRLDLDREP------KKEAVKSFIETQKALLAEIQ 461
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/179 (25%), Positives = 81/179 (45%), Gaps = 29/179 (16%)
Query: 122 LKNLELNGLILRERDLTI-----LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSI 176
L L L L + LT+ L K L + L L++C + + G ++ +G+ ++
Sbjct: 27 LHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANT 86
Query: 177 TLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNC 236
L+ ++ G NL GA+ + K+L+ ++ +TL
Sbjct: 87 VLRFLDLKGNNLRAAGAEALGKLLQQNK-----------------------SIQSLTLEW 123
Query: 237 NTL-IGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKN 294
N+L D F L+ + L+ LDL+ ++++GA+ L AL+ NTTL LD+R N
Sbjct: 124 NSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWN 182
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/193 (23%), Positives = 81/193 (41%), Gaps = 22/193 (11%)
Query: 102 KDVTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIG 161
+ +T + C+AL L ++ L L+ +L E T+L +GL + L L L +
Sbjct: 40 QSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLR 99
Query: 162 DGGLEIICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRP 221
G E + + ++ + +++++ L W TW ++
Sbjct: 100 AAGAEALGKLLQQNKSIQSL-----TLEWNSLG----------------TWDDAFATFCG 138
Query: 222 DLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALE 281
L L+R+ L N I GA A +L + L+ LDL+ + G +AL+ L
Sbjct: 139 GLAANGALQRLDLR-NNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLP 197
Query: 282 TNTTLVVLDIRKN 294
+N TL LD+ N
Sbjct: 198 SNRTLWRLDLAGN 210
Score = 33.5 bits (75), Expect = 0.69
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 261 LDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAKS 318
L L C L+ EGA LL L NT L LD++ N L + + K+LQ +S +S
Sbjct: 63 LVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNL--RAAGAEALGKLLQQNKSIQS 118
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 50.4 bits (119), Expect = 5e-06
Identities = 46/161 (28%), Positives = 64/161 (39%), Gaps = 26/161 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSI-TLKTVNFTGCNLTWQGADHMAK 198
+A L + LV L L + D GL ++CQG++ + L+T+ C LT D +A
Sbjct: 102 MASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAS 161
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLW- 257
L LR + L+ N L GDLG + L
Sbjct: 162 TLSVN-----------------------QSLRELDLSLNEL-GDLGVLLLCEGLRHPTCK 197
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
L+ L L CGLT + + L L N TL L + N L D
Sbjct: 198 LQTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGD 238
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 50.4 bits (119), Expect = 5e-06
Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 8/192 (4%)
Query: 110 KALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIIC 169
KAL L +LK L+L+ L+L L +L L++ L L L IGD G +
Sbjct: 1540 KALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLS 1599
Query: 170 QGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLR-----YRRPDLD 224
+ ++++ +L+ ++ + + G H+A IL R + S+ L
Sbjct: 1600 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLV 1659
Query: 225 CMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNT 284
L + L CN L GD A A L + LR L L L GA +L +AL+ +
Sbjct: 1660 LCRRLEELMLGCNAL-GDPTALGLAQELPQH--LRVLHLPFSHLGPGGALSLAQALDGSP 1716
Query: 285 TLVVLDIRKNPL 296
L + + +N L
Sbjct: 1717 HLEEISLAENNL 1728
Score = 36.6 bits (83), Expect = 0.082
Identities = 58/230 (25%), Positives = 90/230 (39%), Gaps = 23/230 (10%)
Query: 81 LGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISSVLKNLELNGLILRERDLTIL 140
L +T + + + S+V D + L ++L LS+S LK L + L L
Sbjct: 1458 LMETCARLQQLSLSQVNLCEDDDASSLLLQSL--LLSLSE-LKTFRLTSSCVSTEGLAHL 1514
Query: 141 AKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKTVNFTGCNLTWQGADHMAKIL 200
A GL L L L+N + G + + + ++ LK ++ + L + L
Sbjct: 1515 ASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLN-------SSTL 1567
Query: 201 KYQTMRRHEETWAESLRYRRP---DLDCM---------AGLRRITLNCNTLIGDLGACAF 248
T R + T +SLR R D+ C L + L+ N IGD G
Sbjct: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQ-IGDAGVQHL 1626
Query: 249 ADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
A L LR +DL +++ G L E+L L L + N L D
Sbjct: 1627 ATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGD 1676
Score = 32.3 bits (72), Expect = 1.5
Identities = 49/226 (21%), Positives = 92/226 (40%), Gaps = 17/226 (7%)
Query: 81 LGDTGSDMNKFCRSRVPAIRYKDVTFQLCKALKGCLSISSV-----LKNLELNGLILRER 135
+GD G +P +R D++ + G S+ L+ L L L +
Sbjct: 1618 IGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDP 1677
Query: 136 DLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLKTVNFTGCNLTWQGADH 195
LA+ L + ++HL ++ +G GG + Q + S L+ ++ NL A
Sbjct: 1678 TALGLAQELPQHLRVLHLPFSH--LGPGGALSLAQALDGSPHLEEISLAENNL----AGG 1731
Query: 196 MAKILKYQTMRRHEETWA-----ESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFAD 250
+ + + R + + ++ + L I L+ N L+GD A A
Sbjct: 1732 VLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWN-LLGDEAAAELAQ 1790
Query: 251 SLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L + L+ +DL++ +T GA L E L +++ V+ + NP+
Sbjct: 1791 VLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1836
>gi|61175232 hypothetical protein LOC221424 [Homo sapiens]
Length = 316
Score = 49.7 bits (117), Expect = 9e-06
Identities = 52/212 (24%), Positives = 87/212 (41%), Gaps = 38/212 (17%)
Query: 87 DMNKFCRSRVPAIRYKDVTFQL--------CKALKGCLSISSVLKNLELNGLILRERDLT 138
D + CR+ A + L K L L + +++L L+G L + L
Sbjct: 44 DFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLA 103
Query: 139 ILAKGLNKSASLVHLSLANCPIGDGGLEIIC-----QGIKSSITLKTVNFTGCNLTWQGA 193
+L L +LV L L +C +GD + +IC G KS + T++ +T +G
Sbjct: 104 LLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLS-ANPGITPKGW 162
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+A + + + +R + L+ N L GD A A +++
Sbjct: 163 SRLAIAVAHSSQ-----------------------VRVLNLDYNPL-GDHVAGMLAVAVA 198
Query: 254 EDLWLRALDLQQCGLTNEGAKALLEALETNTT 285
L LDL+ GLTN+ A+ LL+ +E T
Sbjct: 199 SSRTLEVLDLEGTGLTNQSAQTLLDMVENYPT 230
Score = 46.6 bits (109), Expect = 8e-05
Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 23/194 (11%)
Query: 107 QLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLE 166
++C+AL G S++ + NL G++ + LA+ L + S+ L L P+ D GL
Sbjct: 47 RICRALAGATSLAQLNLNL---GVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLA 103
Query: 167 IICQGIKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCM 226
++ + L ++ C L + + + +L P
Sbjct: 104 LLNPALALHPALVALDLGDCMLGDEAINLICGLL--------------------PPDGAK 143
Query: 227 AGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTL 286
+GL+ +TL+ N I G A +++ +R L+L L + A L A+ ++ TL
Sbjct: 144 SGLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTL 203
Query: 287 VVLDIRKNPLIDHS 300
VLD+ L + S
Sbjct: 204 EVLDLEGTGLTNQS 217
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 49.3 bits (116), Expect = 1e-05
Identities = 47/182 (25%), Positives = 81/182 (44%), Gaps = 15/182 (8%)
Query: 108 LCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEI 167
LC+AL+ L+ L L L E L+ L + L HL LA+ +GDGG+++
Sbjct: 806 LCEALR---HPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKL 862
Query: 168 ICQGIK-SSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCM 226
+ ++ + TLK++ C+ T +++++ L + H + + L+ L C
Sbjct: 863 MSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCD 922
Query: 227 AGLRRITLNCNTLIGDLGACAFADSLSEDLW--------LRALDLQQCGLTNEGAKALLE 278
+CN +L C ++ DL LR+LDL L ++G K L +
Sbjct: 923 VFRHP---SCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCD 979
Query: 279 AL 280
AL
Sbjct: 980 AL 981
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/197 (23%), Positives = 90/197 (45%), Gaps = 33/197 (16%)
Query: 114 GCLSISSVLKNLE--LNGLILRERDLTI-----LAKGLNKSASLVHLSLANCPIGDGGLE 166
G S+ LK+ E L L L +LT+ ++ L +S SL+ L+L+ + D G++
Sbjct: 745 GVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQ 804
Query: 167 IICQGIKS-SITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDC 225
++C+ ++ L+ ++ C LT G ++++ L H C
Sbjct: 805 LLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHL---------------C 849
Query: 226 MAGLRRITLNCNTLIGDLGACAFADSLSE-DLWLRALDLQQCGLTNEGAKALLEALETNT 284
+A + ++GD G +D+L L++L L++C T+ ++ L +L N
Sbjct: 850 LA---------DNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNK 900
Query: 285 TLVVLDIRKNPLIDHSM 301
+L LD+ N L D+ +
Sbjct: 901 SLTHLDLGSNWLQDNGV 917
Score = 45.4 bits (106), Expect = 2e-04
Identities = 43/161 (26%), Positives = 71/161 (44%), Gaps = 26/161 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L+HL L IGD G++ +C+ +K L+T+ CNLT +++
Sbjct: 721 ISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISN 780
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSED-LW 257
L ++SL + + L+ N L+ D G ++L +
Sbjct: 781 AL----------IRSQSLIF-------------LNLSTNNLLDD-GVQLLCEALRHPKCY 816
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
L L L+ CGLT G + L AL +N L L + N L D
Sbjct: 817 LERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGD 857
Score = 31.6 bits (70), Expect = 2.6
Identities = 19/69 (27%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 122 LKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIK-SSITLKT 180
L++LEL G +L LA + + +L L L N + D G++I+C ++ + ++
Sbjct: 931 LQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQR 990
Query: 181 VNFTGCNLT 189
+ C LT
Sbjct: 991 LGLEYCGLT 999
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 47.8 bits (112), Expect = 4e-05
Identities = 52/195 (26%), Positives = 86/195 (44%), Gaps = 30/195 (15%)
Query: 108 LCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEI 167
LC+AL S +VL L L L E+ +++ L ++ S+ +L L+ + D GL+
Sbjct: 770 LCEAL---CSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKT 826
Query: 168 ICQGIKS-SITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCM 226
+C+ +K L ++ C +T G + +A L
Sbjct: 827 LCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQ---------------------- 864
Query: 227 AGLRRITLNCNTLIGDLGACAFADSLSE-DLWLRALDLQQCGLTNEGAKALLEALETNTT 285
L+ + + CN IGD+G +L+ D L L L++CGLT+ K L L + T
Sbjct: 865 -NLKILQIGCNE-IGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKT 922
Query: 286 LVVLDIRKNPLIDHS 300
L L++ N L DH+
Sbjct: 923 LQQLNLTLNTL-DHT 936
>gi|113205085 leucine rich repeat containing 31 [Homo sapiens]
Length = 552
Score = 47.8 bits (112), Expect = 4e-05
Identities = 48/178 (26%), Positives = 74/178 (41%), Gaps = 30/178 (16%)
Query: 120 SVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSITLK 179
S ++ +EL L D T L + L SL L L+ G L I QG+KS+ LK
Sbjct: 198 SKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLK 257
Query: 180 TVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTL 239
+ C L+ + + +Y + LR++ L+CN
Sbjct: 258 VLKLHSCGLSQKSVKILDAAFRY-----------------------LGELRKLDLSCNK- 293
Query: 240 IGDLGACAFADSLSEDLWLR---ALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKN 294
DLG F DS ++ + L+ LDL QC LT + +L + + + L LD+ N
Sbjct: 294 --DLGG-GFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSAN 348
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 112 LKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG 171
L+G + S ++ L L L +L+ L +L L L++ +GD GL+++C+G
Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136
Query: 172 -IKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLR 230
+ L+ + C+L+ + +A +L+ +PD +
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLR-----------------AKPD------FK 173
Query: 231 RITLNCNTLIGDLGACAFADSLSED-LWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
+T++ N I + G L + L AL L+ CG+T++ + L + + +L L
Sbjct: 174 ELTVS-NNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 290 DIRKNPLIDHSM 301
+ N L D M
Sbjct: 233 ALGSNKLGDVGM 244
Score = 43.1 bits (100), Expect = 9e-04
Identities = 64/286 (22%), Positives = 101/286 (35%), Gaps = 64/286 (22%)
Query: 50 LRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDM------NKFCRSRVPAIRYKD 103
L G L STL+ LP + LGD G + + CR + Y
Sbjct: 97 LTGAGCGVLSSTLRT---LPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKS---------------- 147
++ C+ L L K L ++ + E + +L +GL S
Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213
Query: 148 -------------ASLVHLSLANCPIGDGGLEIICQG-IKSSITLKTVNFTGCNLTWQGA 193
ASL L+L + +GD G+ +C G + S L+T+ C +T +G
Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+ ++L+ L+ ++L N L GD GA ++L
Sbjct: 274 GDLCRVLR-----------------------AKESLKELSLAGNEL-GDEGARLLCETLL 309
Query: 254 E-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
E L +L ++ C T L N L+ L I N L D
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/201 (24%), Positives = 85/201 (42%), Gaps = 25/201 (12%)
Query: 114 GCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG-I 172
G L SS L+ L + + + L + L SL LSLA +GD G ++C+ +
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRI 232
+ L+++ C+ T H + +L + + L+ L+ AG+R +
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLA-------QNRFLLELQISNNRLE-DAGVREL 361
Query: 233 TLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIR 292
C L G G+ LR L L C +++ +L L N +L LD+
Sbjct: 362 ---CQGL-GQPGSV-----------LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406
Query: 293 KNPLIDHSMMKAVIKKVLQNG 313
N L D +++ +++ V Q G
Sbjct: 407 NNCLGDAGILQ-LVESVRQPG 426
Score = 32.7 bits (73), Expect = 1.2
Identities = 32/159 (20%), Positives = 63/159 (39%), Gaps = 26/159 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L L+L + +GD G+ + QG+++ S ++ ++ C LT G ++
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSE-DLW 257
L+ + L+ + L+ N L+GD G + L +
Sbjct: 108 TLR-----------------------TLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCR 143
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L L L+ C L+ + L L L + N +
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 250 DSLSEDLWLRALDLQQ---------CGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ LS+ W L L Q CGLT K + AL N L L++R N L D
Sbjct: 13 EELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD 70
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 112 LKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG 171
L+G + S ++ L L L +L+ L +L L L++ +GD GL+++C+G
Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136
Query: 172 -IKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLR 230
+ L+ + C+L+ + +A +L+ +PD +
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLR-----------------AKPD------FK 173
Query: 231 RITLNCNTLIGDLGACAFADSLSED-LWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
+T++ N I + G L + L AL L+ CG+T++ + L + + +L L
Sbjct: 174 ELTVS-NNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 290 DIRKNPLIDHSM 301
+ N L D M
Sbjct: 233 ALGSNKLGDVGM 244
Score = 43.1 bits (100), Expect = 9e-04
Identities = 64/286 (22%), Positives = 101/286 (35%), Gaps = 64/286 (22%)
Query: 50 LRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDM------NKFCRSRVPAIRYKD 103
L G L STL+ LP + LGD G + + CR + Y
Sbjct: 97 LTGAGCGVLSSTLRT---LPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKS---------------- 147
++ C+ L L K L ++ + E + +L +GL S
Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213
Query: 148 -------------ASLVHLSLANCPIGDGGLEIICQG-IKSSITLKTVNFTGCNLTWQGA 193
ASL L+L + +GD G+ +C G + S L+T+ C +T +G
Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+ ++L+ L+ ++L N L GD GA ++L
Sbjct: 274 GDLCRVLR-----------------------AKESLKELSLAGNEL-GDEGARLLCETLL 309
Query: 254 E-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
E L +L ++ C T L N L+ L I N L D
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/201 (24%), Positives = 85/201 (42%), Gaps = 25/201 (12%)
Query: 114 GCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG-I 172
G L SS L+ L + + + L + L SL LSLA +GD G ++C+ +
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRI 232
+ L+++ C+ T H + +L + + L+ L+ AG+R +
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLA-------QNRFLLELQISNNRLE-DAGVREL 361
Query: 233 TLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIR 292
C L G G+ LR L L C +++ +L L N +L LD+
Sbjct: 362 ---CQGL-GQPGSV-----------LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406
Query: 293 KNPLIDHSMMKAVIKKVLQNG 313
N L D +++ +++ V Q G
Sbjct: 407 NNCLGDAGILQ-LVESVRQPG 426
Score = 32.7 bits (73), Expect = 1.2
Identities = 32/159 (20%), Positives = 63/159 (39%), Gaps = 26/159 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L L+L + +GD G+ + QG+++ S ++ ++ C LT G ++
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSE-DLW 257
L+ + L+ + L+ N L+GD G + L +
Sbjct: 108 TLR-----------------------TLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCR 143
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L L L+ C L+ + L L L + N +
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 250 DSLSEDLWLRALDLQQ---------CGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ LS+ W L L Q CGLT K + AL N L L++R N L D
Sbjct: 13 EELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD 70
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 112 LKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG 171
L+G + S ++ L L L +L+ L +L L L++ +GD GL+++C+G
Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136
Query: 172 -IKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLR 230
+ L+ + C+L+ + +A +L+ +PD +
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLR-----------------AKPD------FK 173
Query: 231 RITLNCNTLIGDLGACAFADSLSED-LWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
+T++ N I + G L + L AL L+ CG+T++ + L + + +L L
Sbjct: 174 ELTVS-NNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 290 DIRKNPLIDHSM 301
+ N L D M
Sbjct: 233 ALGSNKLGDVGM 244
Score = 43.1 bits (100), Expect = 9e-04
Identities = 64/286 (22%), Positives = 101/286 (35%), Gaps = 64/286 (22%)
Query: 50 LRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDM------NKFCRSRVPAIRYKD 103
L G L STL+ LP + LGD G + + CR + Y
Sbjct: 97 LTGAGCGVLSSTLRT---LPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKS---------------- 147
++ C+ L L K L ++ + E + +L +GL S
Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213
Query: 148 -------------ASLVHLSLANCPIGDGGLEIICQG-IKSSITLKTVNFTGCNLTWQGA 193
ASL L+L + +GD G+ +C G + S L+T+ C +T +G
Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+ ++L+ L+ ++L N L GD GA ++L
Sbjct: 274 GDLCRVLR-----------------------AKESLKELSLAGNEL-GDEGARLLCETLL 309
Query: 254 E-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
E L +L ++ C T L N L+ L I N L D
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/201 (24%), Positives = 85/201 (42%), Gaps = 25/201 (12%)
Query: 114 GCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG-I 172
G L SS L+ L + + + L + L SL LSLA +GD G ++C+ +
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRI 232
+ L+++ C+ T H + +L + + L+ L+ AG+R +
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLA-------QNRFLLELQISNNRLE-DAGVREL 361
Query: 233 TLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIR 292
C L G G+ LR L L C +++ +L L N +L LD+
Sbjct: 362 ---CQGL-GQPGSV-----------LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406
Query: 293 KNPLIDHSMMKAVIKKVLQNG 313
N L D +++ +++ V Q G
Sbjct: 407 NNCLGDAGILQ-LVESVRQPG 426
Score = 32.7 bits (73), Expect = 1.2
Identities = 32/159 (20%), Positives = 63/159 (39%), Gaps = 26/159 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L L+L + +GD G+ + QG+++ S ++ ++ C LT G ++
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSE-DLW 257
L+ + L+ + L+ N L+GD G + L +
Sbjct: 108 TLR-----------------------TLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCR 143
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L L L+ C L+ + L L L + N +
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 250 DSLSEDLWLRALDLQQ---------CGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ LS+ W L L Q CGLT K + AL N L L++R N L D
Sbjct: 13 EELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD 70
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 112 LKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG 171
L+G + S ++ L L L +L+ L +L L L++ +GD GL+++C+G
Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136
Query: 172 -IKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLR 230
+ L+ + C+L+ + +A +L+ +PD +
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLR-----------------AKPD------FK 173
Query: 231 RITLNCNTLIGDLGACAFADSLSED-LWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
+T++ N I + G L + L AL L+ CG+T++ + L + + +L L
Sbjct: 174 ELTVS-NNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 290 DIRKNPLIDHSM 301
+ N L D M
Sbjct: 233 ALGSNKLGDVGM 244
Score = 43.1 bits (100), Expect = 9e-04
Identities = 64/286 (22%), Positives = 101/286 (35%), Gaps = 64/286 (22%)
Query: 50 LRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDM------NKFCRSRVPAIRYKD 103
L G L STL+ LP + LGD G + + CR + Y
Sbjct: 97 LTGAGCGVLSSTLRT---LPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKS---------------- 147
++ C+ L L K L ++ + E + +L +GL S
Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213
Query: 148 -------------ASLVHLSLANCPIGDGGLEIICQG-IKSSITLKTVNFTGCNLTWQGA 193
ASL L+L + +GD G+ +C G + S L+T+ C +T +G
Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+ ++L+ L+ ++L N L GD GA ++L
Sbjct: 274 GDLCRVLR-----------------------AKESLKELSLAGNEL-GDEGARLLCETLL 309
Query: 254 E-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
E L +L ++ C T L N L+ L I N L D
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/201 (24%), Positives = 85/201 (42%), Gaps = 25/201 (12%)
Query: 114 GCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG-I 172
G L SS L+ L + + + L + L SL LSLA +GD G ++C+ +
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRI 232
+ L+++ C+ T H + +L + + L+ L+ AG+R +
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLA-------QNRFLLELQISNNRLE-DAGVREL 361
Query: 233 TLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIR 292
C L G G+ LR L L C +++ +L L N +L LD+
Sbjct: 362 ---CQGL-GQPGSV-----------LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406
Query: 293 KNPLIDHSMMKAVIKKVLQNG 313
N L D +++ +++ V Q G
Sbjct: 407 NNCLGDAGILQ-LVESVRQPG 426
Score = 32.7 bits (73), Expect = 1.2
Identities = 32/159 (20%), Positives = 63/159 (39%), Gaps = 26/159 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L L+L + +GD G+ + QG+++ S ++ ++ C LT G ++
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSE-DLW 257
L+ + L+ + L+ N L+GD G + L +
Sbjct: 108 TLR-----------------------TLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCR 143
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L L L+ C L+ + L L L + N +
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 250 DSLSEDLWLRALDLQQ---------CGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ LS+ W L L Q CGLT K + AL N L L++R N L D
Sbjct: 13 EELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD 70
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 112 LKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG 171
L+G + S ++ L L L +L+ L +L L L++ +GD GL+++C+G
Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136
Query: 172 -IKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLR 230
+ L+ + C+L+ + +A +L+ +PD +
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLR-----------------AKPD------FK 173
Query: 231 RITLNCNTLIGDLGACAFADSLSED-LWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
+T++ N I + G L + L AL L+ CG+T++ + L + + +L L
Sbjct: 174 ELTVS-NNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 290 DIRKNPLIDHSM 301
+ N L D M
Sbjct: 233 ALGSNKLGDVGM 244
Score = 43.1 bits (100), Expect = 9e-04
Identities = 64/286 (22%), Positives = 101/286 (35%), Gaps = 64/286 (22%)
Query: 50 LRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDM------NKFCRSRVPAIRYKD 103
L G L STL+ LP + LGD G + + CR + Y
Sbjct: 97 LTGAGCGVLSSTLRT---LPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKS---------------- 147
++ C+ L L K L ++ + E + +L +GL S
Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213
Query: 148 -------------ASLVHLSLANCPIGDGGLEIICQG-IKSSITLKTVNFTGCNLTWQGA 193
ASL L+L + +GD G+ +C G + S L+T+ C +T +G
Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+ ++L+ L+ ++L N L GD GA ++L
Sbjct: 274 GDLCRVLR-----------------------AKESLKELSLAGNEL-GDEGARLLCETLL 309
Query: 254 E-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
E L +L ++ C T L N L+ L I N L D
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/201 (24%), Positives = 85/201 (42%), Gaps = 25/201 (12%)
Query: 114 GCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG-I 172
G L SS L+ L + + + L + L SL LSLA +GD G ++C+ +
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRI 232
+ L+++ C+ T H + +L + + L+ L+ AG+R +
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLA-------QNRFLLELQISNNRLE-DAGVREL 361
Query: 233 TLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIR 292
C L G G+ LR L L C +++ +L L N +L LD+
Sbjct: 362 ---CQGL-GQPGSV-----------LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406
Query: 293 KNPLIDHSMMKAVIKKVLQNG 313
N L D +++ +++ V Q G
Sbjct: 407 NNCLGDAGILQ-LVESVRQPG 426
Score = 32.7 bits (73), Expect = 1.2
Identities = 32/159 (20%), Positives = 63/159 (39%), Gaps = 26/159 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L L+L + +GD G+ + QG+++ S ++ ++ C LT G ++
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSE-DLW 257
L+ + L+ + L+ N L+GD G + L +
Sbjct: 108 TLR-----------------------TLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCR 143
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L L L+ C L+ + L L L + N +
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 250 DSLSEDLWLRALDLQQ---------CGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ LS+ W L L Q CGLT K + AL N L L++R N L D
Sbjct: 13 EELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD 70
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 112 LKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG 171
L+G + S ++ L L L +L+ L +L L L++ +GD GL+++C+G
Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136
Query: 172 -IKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLR 230
+ L+ + C+L+ + +A +L+ +PD +
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLR-----------------AKPD------FK 173
Query: 231 RITLNCNTLIGDLGACAFADSLSED-LWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
+T++ N I + G L + L AL L+ CG+T++ + L + + +L L
Sbjct: 174 ELTVS-NNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 290 DIRKNPLIDHSM 301
+ N L D M
Sbjct: 233 ALGSNKLGDVGM 244
Score = 43.1 bits (100), Expect = 9e-04
Identities = 64/286 (22%), Positives = 101/286 (35%), Gaps = 64/286 (22%)
Query: 50 LRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDM------NKFCRSRVPAIRYKD 103
L G L STL+ LP + LGD G + + CR + Y
Sbjct: 97 LTGAGCGVLSSTLRT---LPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKS---------------- 147
++ C+ L L K L ++ + E + +L +GL S
Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213
Query: 148 -------------ASLVHLSLANCPIGDGGLEIICQG-IKSSITLKTVNFTGCNLTWQGA 193
ASL L+L + +GD G+ +C G + S L+T+ C +T +G
Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+ ++L+ L+ ++L N L GD GA ++L
Sbjct: 274 GDLCRVLR-----------------------AKESLKELSLAGNEL-GDEGARLLCETLL 309
Query: 254 E-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
E L +L ++ C T L N L+ L I N L D
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/201 (24%), Positives = 85/201 (42%), Gaps = 25/201 (12%)
Query: 114 GCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG-I 172
G L SS L+ L + + + L + L SL LSLA +GD G ++C+ +
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRI 232
+ L+++ C+ T H + +L + + L+ L+ AG+R +
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLA-------QNRFLLELQISNNRLE-DAGVREL 361
Query: 233 TLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIR 292
C L G G+ LR L L C +++ +L L N +L LD+
Sbjct: 362 ---CQGL-GQPGSV-----------LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406
Query: 293 KNPLIDHSMMKAVIKKVLQNG 313
N L D +++ +++ V Q G
Sbjct: 407 NNCLGDAGILQ-LVESVRQPG 426
Score = 32.7 bits (73), Expect = 1.2
Identities = 32/159 (20%), Positives = 63/159 (39%), Gaps = 26/159 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L L+L + +GD G+ + QG+++ S ++ ++ C LT G ++
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSE-DLW 257
L+ + L+ + L+ N L+GD G + L +
Sbjct: 108 TLR-----------------------TLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCR 143
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L L L+ C L+ + L L L + N +
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 250 DSLSEDLWLRALDLQQ---------CGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ LS+ W L L Q CGLT K + AL N L L++R N L D
Sbjct: 13 EELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD 70
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 112 LKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG 171
L+G + S ++ L L L +L+ L +L L L++ +GD GL+++C+G
Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136
Query: 172 -IKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLR 230
+ L+ + C+L+ + +A +L+ +PD +
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLR-----------------AKPD------FK 173
Query: 231 RITLNCNTLIGDLGACAFADSLSED-LWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
+T++ N I + G L + L AL L+ CG+T++ + L + + +L L
Sbjct: 174 ELTVS-NNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 290 DIRKNPLIDHSM 301
+ N L D M
Sbjct: 233 ALGSNKLGDVGM 244
Score = 43.1 bits (100), Expect = 9e-04
Identities = 64/286 (22%), Positives = 101/286 (35%), Gaps = 64/286 (22%)
Query: 50 LRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDM------NKFCRSRVPAIRYKD 103
L G L STL+ LP + LGD G + + CR + Y
Sbjct: 97 LTGAGCGVLSSTLRT---LPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKS---------------- 147
++ C+ L L K L ++ + E + +L +GL S
Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213
Query: 148 -------------ASLVHLSLANCPIGDGGLEIICQG-IKSSITLKTVNFTGCNLTWQGA 193
ASL L+L + +GD G+ +C G + S L+T+ C +T +G
Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+ ++L+ L+ ++L N L GD GA ++L
Sbjct: 274 GDLCRVLR-----------------------AKESLKELSLAGNEL-GDEGARLLCETLL 309
Query: 254 E-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
E L +L ++ C T L N L+ L I N L D
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/201 (24%), Positives = 85/201 (42%), Gaps = 25/201 (12%)
Query: 114 GCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG-I 172
G L SS L+ L + + + L + L SL LSLA +GD G ++C+ +
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRI 232
+ L+++ C+ T H + +L + + L+ L+ AG+R +
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLA-------QNRFLLELQISNNRLE-DAGVREL 361
Query: 233 TLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIR 292
C L G G+ LR L L C +++ +L L N +L LD+
Sbjct: 362 ---CQGL-GQPGSV-----------LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406
Query: 293 KNPLIDHSMMKAVIKKVLQNG 313
N L D +++ +++ V Q G
Sbjct: 407 NNCLGDAGILQ-LVESVRQPG 426
Score = 32.7 bits (73), Expect = 1.2
Identities = 32/159 (20%), Positives = 63/159 (39%), Gaps = 26/159 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L L+L + +GD G+ + QG+++ S ++ ++ C LT G ++
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSE-DLW 257
L+ + L+ + L+ N L+GD G + L +
Sbjct: 108 TLR-----------------------TLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCR 143
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L L L+ C L+ + L L L + N +
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 250 DSLSEDLWLRALDLQQ---------CGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ LS+ W L L Q CGLT K + AL N L L++R N L D
Sbjct: 13 EELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD 70
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/192 (22%), Positives = 82/192 (42%), Gaps = 26/192 (13%)
Query: 112 LKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG 171
L+G + S ++ L L L +L+ L +L L L++ +GD GL+++C+G
Sbjct: 77 LQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEG 136
Query: 172 -IKSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLR 230
+ L+ + C+L+ + +A +L+ +PD +
Sbjct: 137 LLDPQCRLEKLQLEYCSLSAASCEPLASVLR-----------------AKPD------FK 173
Query: 231 RITLNCNTLIGDLGACAFADSLSED-LWLRALDLQQCGLTNEGAKALLEALETNTTLVVL 289
+T++ N I + G L + L AL L+ CG+T++ + L + + +L L
Sbjct: 174 ELTVS-NNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLREL 232
Query: 290 DIRKNPLIDHSM 301
+ N L D M
Sbjct: 233 ALGSNKLGDVGM 244
Score = 43.1 bits (100), Expect = 9e-04
Identities = 64/286 (22%), Positives = 101/286 (35%), Gaps = 64/286 (22%)
Query: 50 LRGVDWAPLLSTLKINKDLPLVSIKSFFQPWLGDTGSDM------NKFCRSRVPAIRYKD 103
L G L STL+ LP + LGD G + + CR + Y
Sbjct: 97 LTGAGCGVLSSTLRT---LPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCS 153
Query: 104 VTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKS---------------- 147
++ C+ L L K L ++ + E + +L +GL S
Sbjct: 154 LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTS 213
Query: 148 -------------ASLVHLSLANCPIGDGGLEIICQG-IKSSITLKTVNFTGCNLTWQGA 193
ASL L+L + +GD G+ +C G + S L+T+ C +T +G
Sbjct: 214 DNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 194 DHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLS 253
+ ++L+ L+ ++L N L GD GA ++L
Sbjct: 274 GDLCRVLR-----------------------AKESLKELSLAGNEL-GDEGARLLCETLL 309
Query: 254 E-DLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
E L +L ++ C T L N L+ L I N L D
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLED 355
Score = 37.4 bits (85), Expect = 0.048
Identities = 49/201 (24%), Positives = 85/201 (42%), Gaps = 25/201 (12%)
Query: 114 GCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQG-I 172
G L SS L+ L + + + L + L SL LSLA +GD G ++C+ +
Sbjct: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
Query: 173 KSSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRI 232
+ L+++ C+ T H + +L + + L+ L+ AG+R +
Sbjct: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLA-------QNRFLLELQISNNRLE-DAGVREL 361
Query: 233 TLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIR 292
C L G G+ LR L L C +++ +L L N +L LD+
Sbjct: 362 ---CQGL-GQPGSV-----------LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLS 406
Query: 293 KNPLIDHSMMKAVIKKVLQNG 313
N L D +++ +++ V Q G
Sbjct: 407 NNCLGDAGILQ-LVESVRQPG 426
Score = 32.7 bits (73), Expect = 1.2
Identities = 32/159 (20%), Positives = 63/159 (39%), Gaps = 26/159 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKS-SITLKTVNFTGCNLTWQGADHMAK 198
++ L + +L L+L + +GD G+ + QG+++ S ++ ++ C LT G ++
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSE-DLW 257
L+ + L+ + L+ N L+GD G + L +
Sbjct: 108 TLR-----------------------TLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCR 143
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPL 296
L L L+ C L+ + L L L + N +
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 9/58 (15%)
Query: 250 DSLSEDLWLRALDLQQ---------CGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
+ LS+ W L L Q CGLT K + AL N L L++R N L D
Sbjct: 13 EELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGD 70
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 45.8 bits (107), Expect = 1e-04
Identities = 48/183 (26%), Positives = 75/183 (40%), Gaps = 25/183 (13%)
Query: 122 LKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIK-SSITLKT 180
L+ L L L E LA L S L HL LA PIGD G++ +C+G+ L+T
Sbjct: 820 LQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQT 879
Query: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI 240
+ C++T G ++++ L+ E+ DL R + + C L
Sbjct: 880 LVLQQCSITKLGCRYLSEALQ------------EACSLTNLDLSINQIARGLWILCQAL- 926
Query: 241 GDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHS 300
+ + L+ L L C L + L AL +N L LD+ +N L
Sbjct: 927 -----------ENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSG 975
Query: 301 MMK 303
++K
Sbjct: 976 IIK 978
Score = 35.0 bits (79), Expect = 0.24
Identities = 44/195 (22%), Positives = 70/195 (35%), Gaps = 19/195 (9%)
Query: 117 SISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSI 176
S +S LK LE+ L + + IL + +S + D C
Sbjct: 672 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKK 731
Query: 177 TLKTVNFTGCNLTWQGA----------DHMAKILKYQTMRRH---EETWAESLRYRRPDL 223
TL + G ++ W+ +H L+Y + H E WAE L
Sbjct: 732 TLTHLTLAG-HIEWERTMMLMLCDLLRNHKCN-LQYLRLGGHCATPEQWAEFFYV----L 785
Query: 224 DCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETN 283
L+ + L+ N L+ + + +L+ L L+ C LT K L L +
Sbjct: 786 KANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVS 845
Query: 284 TTLVVLDIRKNPLID 298
L L + KNP+ D
Sbjct: 846 KKLTHLCLAKNPIGD 860
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 45.8 bits (107), Expect = 1e-04
Identities = 48/183 (26%), Positives = 75/183 (40%), Gaps = 25/183 (13%)
Query: 122 LKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIK-SSITLKT 180
L+ L L L E LA L S L HL LA PIGD G++ +C+G+ L+T
Sbjct: 792 LQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQT 851
Query: 181 VNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLI 240
+ C++T G ++++ L+ E+ DL R + + C L
Sbjct: 852 LVLQQCSITKLGCRYLSEALQ------------EACSLTNLDLSINQIARGLWILCQAL- 898
Query: 241 GDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLIDHS 300
+ + L+ L L C L + L AL +N L LD+ +N L
Sbjct: 899 -----------ENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSG 947
Query: 301 MMK 303
++K
Sbjct: 948 IIK 950
Score = 35.0 bits (79), Expect = 0.24
Identities = 44/195 (22%), Positives = 70/195 (35%), Gaps = 19/195 (9%)
Query: 117 SISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSI 176
S +S LK LE+ L + + IL + +S + D C
Sbjct: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKK 703
Query: 177 TLKTVNFTGCNLTWQGA----------DHMAKILKYQTMRRH---EETWAESLRYRRPDL 223
TL + G ++ W+ +H L+Y + H E WAE L
Sbjct: 704 TLTHLTLAG-HIEWERTMMLMLCDLLRNHKCN-LQYLRLGGHCATPEQWAEFFYV----L 757
Query: 224 DCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETN 283
L+ + L+ N L+ + + +L+ L L+ C LT K L L +
Sbjct: 758 KANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVS 817
Query: 284 TTLVVLDIRKNPLID 298
L L + KNP+ D
Sbjct: 818 KKLTHLCLAKNPIGD 832
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/161 (27%), Positives = 63/161 (39%), Gaps = 26/161 (16%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIKSSIT-LKTVNFTGCNLTWQGADHMAK 198
+A L + LV L L + D GL ++CQG++ + L+T+ C LT D +A
Sbjct: 819 MASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAS 878
Query: 199 ILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLW- 257
L LR + L+ N L GDLG + L
Sbjct: 879 TLSVNQ-----------------------SLRELDLSLNEL-GDLGVLLLCEGLRHPTCK 914
Query: 258 LRALDLQQCGLTNEGAKALLEALETNTTLVVLDIRKNPLID 298
L+ L L C L + + L L+ N L LD+ N L D
Sbjct: 915 LQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGD 955
Score = 38.1 bits (87), Expect = 0.028
Identities = 49/209 (23%), Positives = 80/209 (38%), Gaps = 54/209 (25%)
Query: 92 CRSRVPAIRYKDVTFQLCKALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLV 151
CR R ++ +T C L LS++ L+ L+L+ LN+
Sbjct: 856 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLS---------------LNE----- 895
Query: 152 HLSLANCPIGDGGLEIICQGIK-SSITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEE 210
+GD G+ ++C+G++ + L+T+ C L + ++ +L+
Sbjct: 896 --------LGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQ--------- 938
Query: 211 TWAESLRYRRPDLDCMAGLRRITLNCNTLIGDLGACAFADSLSEDLW-LRALDLQQCGLT 269
LR + L+ N L GD G A+ L L+ L L CGLT
Sbjct: 939 --------------ANHNLRELDLSFNDL-GDWGLWLLAEGLQHPACRLQKLWLDSCGLT 983
Query: 270 NEGAKALLEALETNTTLVVLDIRKNPLID 298
+ + L L N TL L + N L D
Sbjct: 984 AKACENLYFTLGINQTLTDLYLTNNALGD 1012
Score = 37.0 bits (84), Expect = 0.063
Identities = 47/196 (23%), Positives = 75/196 (38%), Gaps = 39/196 (19%)
Query: 140 LAKGLNKSASLVHLSLANCPIGDGGLEIICQGIK------------------------SS 175
LA L + +L+ LSL +G G++++CQG++ S+
Sbjct: 705 LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764
Query: 176 ITLKTVNFTGCNLTWQGADHMAKILKYQTMRRHEETWAESLRYRRPDLDCMA-------- 227
+ N T +L+ G +L + + RH + + ++ R+ L+ A
Sbjct: 765 ALIANKNLTRMDLSGNGVGFPGMMLLCEGL-RHPQCRLQMIQLRKCQLESGACQEMASVL 823
Query: 228 ----GLRRITLNCNTLIGDLGACAFADSLSEDLW-LRALDLQQCGLTNEGAKALLEALET 282
L + L N L DLG L + LR L L+ C LT L L
Sbjct: 824 GTNPHLVELDLTGNAL-EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSV 882
Query: 283 NTTLVVLDIRKNPLID 298
N +L LD+ N L D
Sbjct: 883 NQSLRELDLSLNELGD 898
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 44.7 bits (104), Expect = 3e-04
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 9/214 (4%)
Query: 110 KALKGCLSISSVLKNLELNGLILRERDLTILAKGLNKSASLVHLSLANCPIGDGGLEIIC 169
KA+ L + + LEL + E + L + L ++ L ++++N +G G II
Sbjct: 123 KAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIIS 182
Query: 170 QGI-KSSITLKTVNFTGCNLTWQGADHMAKIL--KYQTMR---RHEETWAESLRYRRPDL 223
++S ++ ++ +G + A + + L YQ + H + + L
Sbjct: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQML 242
Query: 224 DCMAGLRRITLNCNTLIGDLGACAFADSLSEDLWLRALDLQQCGLTNEGAKALLEALETN 283
GL + L+ N GA A + L ++ L LDL G NE A AL E L N
Sbjct: 243 AINVGLTSLDLSWNN-FHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLN 301
Query: 284 TTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSAK 317
LV LDI N + + K I K L++ S +
Sbjct: 302 RCLVYLDIGGNDIGNEGASK--ISKGLESNESLR 333
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,229,804
Number of Sequences: 37866
Number of extensions: 1312436
Number of successful extensions: 7349
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 130
Number of HSP's that attempted gapping in prelim test: 6771
Number of HSP's gapped (non-prelim): 590
length of query: 706
length of database: 18,247,518
effective HSP length: 109
effective length of query: 597
effective length of database: 14,120,124
effective search space: 8429714028
effective search space used: 8429714028
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.