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Search of human proteins with 148922920
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
(1496 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 3045 0.0
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 1041 0.0
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 1041 0.0
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 716 0.0
gi|29788755 SET binding factor 2 [Homo sapiens] 152 3e-36
gi|239735519 SET binding factor 1 [Homo sapiens] 128 4e-29
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 104 7e-22
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 100 8e-21
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 88 5e-17
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 86 3e-16
gi|209863002 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|209862998 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|209862994 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|18860873 MAP-kinase activating death domain-containing protei... 84 1e-15
gi|209862987 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|209862983 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|209862979 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|209862975 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|209862971 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|209571517 MAP-kinase activating death domain-containing prote... 84 1e-15
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 77 1e-13
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 75 4e-13
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 72 4e-12
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 72 5e-12
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 72 5e-12
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 72 5e-12
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 69 3e-11
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 69 4e-11
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 69 4e-11
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 62 4e-09
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 3045 bits (7894), Expect = 0.0
Identities = 1496/1496 (100%), Positives = 1496/1496 (100%)
Query: 1 MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE 60
MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE
Sbjct: 1 MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE 60
Query: 61 VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ 120
VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ
Sbjct: 61 VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ 120
Query: 121 VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC 180
VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC
Sbjct: 121 VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC 180
Query: 181 RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM 240
RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM
Sbjct: 181 RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM 240
Query: 241 GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA 300
GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA
Sbjct: 241 GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA 300
Query: 301 VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN 360
VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN
Sbjct: 301 VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN 360
Query: 361 VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE 420
VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE
Sbjct: 361 VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE 420
Query: 421 HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF 480
HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF
Sbjct: 421 HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF 480
Query: 481 DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE 540
DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE
Sbjct: 481 DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE 540
Query: 541 EEASLEFLLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVD 600
EEASLEFLLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVD
Sbjct: 541 EEASLEFLLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVD 600
Query: 601 NLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQ 660
NLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQ
Sbjct: 601 NLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQ 660
Query: 661 EKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFESLQEQ 720
EKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFESLQEQ
Sbjct: 661 EKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFESLQEQ 720
Query: 721 PGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLP 780
PGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLP
Sbjct: 721 PGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLP 780
Query: 781 AYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMR 840
AYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMR
Sbjct: 781 AYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMR 840
Query: 841 QAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRERQQQQQQ 900
QAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRERQQQQQQ
Sbjct: 841 QAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRERQQQQQQ 900
Query: 901 QQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVK 960
QQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVK
Sbjct: 901 QQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVK 960
Query: 961 SGSLGSARGAQPTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGG 1020
SGSLGSARGAQPTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGG
Sbjct: 961 SGSLGSARGAQPTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGG 1020
Query: 1021 SGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARLQQLLTPSRHSPASRIPPPE 1080
SGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARLQQLLTPSRHSPASRIPPPE
Sbjct: 1021 SGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARLQQLLTPSRHSPASRIPPPE 1080
Query: 1081 LPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSD 1140
LPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSD
Sbjct: 1081 LPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSD 1140
Query: 1141 TPGSFQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSV 1200
TPGSFQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSV
Sbjct: 1141 TPGSFQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSV 1200
Query: 1201 QTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLALDEPQLCNGHMGGASRRVE 1260
QTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLALDEPQLCNGHMGGASRRVE
Sbjct: 1201 QTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLALDEPQLCNGHMGGASRRVE 1260
Query: 1261 SGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGL 1320
SGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGL
Sbjct: 1261 SGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGL 1320
Query: 1321 VLASCDGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVW 1380
VLASCDGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVW
Sbjct: 1321 VLASCDGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVW 1380
Query: 1381 PGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAA 1440
PGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAA
Sbjct: 1381 PGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAA 1440
Query: 1441 LGKDHVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAPPEC 1496
LGKDHVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAPPEC
Sbjct: 1441 LGKDHVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAPPEC 1496
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 1041 bits (2691), Expect = 0.0
Identities = 516/906 (56%), Positives = 660/906 (72%), Gaps = 17/906 (1%)
Query: 1 MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE 60
M E++ PR+ DYFVVAGL P+ EE + + P+ EPITDV+VI ++LGEE
Sbjct: 1 MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPK--EPITDVSVIIKSLGEE 58
Query: 61 VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ 120
VPQ Y CI + G +L+ G L G Q +CYRRGRDKPPL +LGVLY+ KER K G +
Sbjct: 59 VPQDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCE 118
Query: 121 VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC 180
++ +TPY AN++ R Y+TYRRA+E + L +TD+C+++PSKGE PHT+C
Sbjct: 119 IIQSTPYGRPANISG-STSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFC 177
Query: 181 RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM 240
++ +NLN MWG AVYLCYK +AK NT+ Y+A L+ RYP+ED E+F LPESVP+FCLPM
Sbjct: 178 KVDKNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPM 237
Query: 241 GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA 300
GATIECWP+ +KYP+PVFSTFVLTGA+ +KVYGAA+QFYE + L+E+Q LGL SA
Sbjct: 238 GATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSA 297
Query: 301 VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN 360
G++ + + + + I +LS WP F AFR FLTFLYRYS+SGPH LP+E HISHF+H
Sbjct: 298 --DGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHK 355
Query: 361 VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE 420
VPFPSPQRPRILVQ+SP+DNL+L QPVSSPLPLSG F LLQ+LGPE A+TLL+ +TE
Sbjct: 356 VPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTE 415
Query: 421 HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF 480
HK+L+HSLRP +LTSV EALVSMIFP HW CPY+PLCPL LADVLSAP PFIVGI S YF
Sbjct: 416 HKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYF 475
Query: 481 DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE 540
DL+DPP DV CVD+DTNT+ Q +KK ++ + LP++P K L+ TL NL+QQL + P
Sbjct: 476 DLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPR 535
Query: 541 EEASLEFLLTDYEAVCGRRAR-LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDV 599
++ ++ + DY+ G+R ++ E+Q AFL FMA +LKGYR +LRP+TQAPSE A D
Sbjct: 536 DDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDA 595
Query: 600 DNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPE 659
+LF LQ FL+SR+RS K Y+ + TQMF +FIEECSF S + A+L FFD CV+KV +
Sbjct: 596 ASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKV--D 653
Query: 660 QEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFES--- 716
+K L+EL+E SE TVF+TPPE P LP G E QY Y+GFP LR LFE
Sbjct: 654 MDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEG 713
Query: 717 -LQEQPGALPVPGPSRSAPSSPAP--RRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYG 773
LQ + LP S+P+SP P RRTKQE+K A ++A++ +++P++W+RCLL HCYG
Sbjct: 714 FLQAKKNKLP---SKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYG 770
Query: 774 LWFLCLPAYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSV 833
LWF+CLPAYV+ S+V+AL TAY VL++M+S K+ PDEVCYR+LMQLC Y QPVL+V
Sbjct: 771 LWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAV 830
Query: 834 RVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRE 893
RV+ EM++AGI PN ITYGYYNKAVLES WPS + G W K+RNVVLG QF++ L++
Sbjct: 831 RVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKK 890
Query: 894 RQQQQQ 899
Q
Sbjct: 891 HAHLSQ 896
Score = 179 bits (455), Expect = 1e-44
Identities = 95/228 (41%), Positives = 142/228 (62%), Gaps = 3/228 (1%)
Query: 1266 YLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASC 1325
YLSPLV+ KELESL+ENEG + + + HPI+FWNL+WYF+RL LPS LPGL+L+S
Sbjct: 1680 YLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSE 1739
Query: 1326 DGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVP 1385
+S+ P ++ D V +++LWD + + PLY+LW H+Q V
Sbjct: 1740 HCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSD 1799
Query: 1386 ASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKDH 1445
S + LL+S+++ + +N+V+ + +LETL P QR +YREILFL++ ALG+++
Sbjct: 1800 NSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCP-HFKRQRSLYREILFLSLVALGREN 1858
Query: 1446 VDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAP 1493
+DI AFDK+YK A+++L S K H + P+ ++CRK FG P
Sbjct: 1859 IDIDAFDKEYKMAYDRLTPSQVKS--THNCDRPPSTGVMECRKTFGEP 1904
Score = 99.4 bits (246), Expect = 2e-20
Identities = 54/97 (55%), Positives = 67/97 (69%), Gaps = 3/97 (3%)
Query: 1110 ESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYD 1169
ESSASL E LS+ +L S SS S+T FQ+ ++E+L+SSCS CR CD LV+D
Sbjct: 1449 ESSASL--EGSLSKFALPGKSEVTSSFNASNT-NIFQNYAMEVLISSCSRCRTCDCLVHD 1505
Query: 1170 EEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSR 1206
EEIMAGW DDSNLNTTCPFC F+P L+++ D R
Sbjct: 1506 EEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLR 1542
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 1041 bits (2691), Expect = 0.0
Identities = 516/906 (56%), Positives = 660/906 (72%), Gaps = 17/906 (1%)
Query: 1 MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE 60
M E++ PR+ DYFVVAGL P+ EE + + P+ EPITDV+VI ++LGEE
Sbjct: 1 MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPK--EPITDVSVIIKSLGEE 58
Query: 61 VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ 120
VPQ Y CI + G +L+ G L G Q +CYRRGRDKPPL +LGVLY+ KER K G +
Sbjct: 59 VPQDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCE 118
Query: 121 VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC 180
++ +TPY AN++ R Y+TYRRA+E + L +TD+C+++PSKGE PHT+C
Sbjct: 119 IIQSTPYGRPANISG-STSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFC 177
Query: 181 RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM 240
++ +NLN MWG AVYLCYK +AK NT+ Y+A L+ RYP+ED E+F LPESVP+FCLPM
Sbjct: 178 KVDKNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPM 237
Query: 241 GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA 300
GATIECWP+ +KYP+PVFSTFVLTGA+ +KVYGAA+QFYE + L+E+Q LGL SA
Sbjct: 238 GATIECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSA 297
Query: 301 VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN 360
G++ + + + + I +LS WP F AFR FLTFLYRYS+SGPH LP+E HISHF+H
Sbjct: 298 --DGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHK 355
Query: 361 VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE 420
VPFPSPQRPRILVQ+SP+DNL+L QPVSSPLPLSG F LLQ+LGPE A+TLL+ +TE
Sbjct: 356 VPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTE 415
Query: 421 HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF 480
HK+L+HSLRP +LTSV EALVSMIFP HW CPY+PLCPL LADVLSAP PFIVGI S YF
Sbjct: 416 HKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYF 475
Query: 481 DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE 540
DL+DPP DV CVD+DTNT+ Q +KK ++ + LP++P K L+ TL NL+QQL + P
Sbjct: 476 DLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPR 535
Query: 541 EEASLEFLLTDYEAVCGRRAR-LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDV 599
++ ++ + DY+ G+R ++ E+Q AFL FMA +LKGYR +LRP+TQAPSE A D
Sbjct: 536 DDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDA 595
Query: 600 DNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPE 659
+LF LQ FL+SR+RS K Y+ + TQMF +FIEECSF S + A+L FFD CV+KV +
Sbjct: 596 ASLFALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKV--D 653
Query: 660 QEKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFES--- 716
+K L+EL+E SE TVF+TPPE P LP G E QY Y+GFP LR LFE
Sbjct: 654 MDKSGEVRLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEG 713
Query: 717 -LQEQPGALPVPGPSRSAPSSPAP--RRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYG 773
LQ + LP S+P+SP P RRTKQE+K A ++A++ +++P++W+RCLL HCYG
Sbjct: 714 FLQAKKNKLP---SKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYG 770
Query: 774 LWFLCLPAYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSV 833
LWF+CLPAYV+ S+V+AL TAY VL++M+S K+ PDEVCYR+LMQLC Y QPVL+V
Sbjct: 771 LWFICLPAYVKVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAV 830
Query: 834 RVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRE 893
RV+ EM++AGI PN ITYGYYNKAVLES WPS + G W K+RNVVLG QF++ L++
Sbjct: 831 RVLFEMQKAGIDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKK 890
Query: 894 RQQQQQ 899
Q
Sbjct: 891 HAHLSQ 896
Score = 179 bits (455), Expect = 1e-44
Identities = 95/228 (41%), Positives = 142/228 (62%), Gaps = 3/228 (1%)
Query: 1266 YLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASC 1325
YLSPLV+ KELESL+ENEG + + + HPI+FWNL+WYF+RL LPS LPGL+L+S
Sbjct: 1637 YLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFRRLDLPSNLPGLILSSE 1696
Query: 1326 DGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVWPGPVP 1385
+S+ P ++ D V +++LWD + + PLY+LW H+Q V
Sbjct: 1697 HCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWNAHTQKYPMVHLLQKSD 1756
Query: 1386 ASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKDH 1445
S + LL+S+++ + +N+V+ + +LETL P QR +YREILFL++ ALG+++
Sbjct: 1757 NSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCP-HFKRQRSLYREILFLSLVALGREN 1815
Query: 1446 VDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAP 1493
+DI AFDK+YK A+++L S K H + P+ ++CRK FG P
Sbjct: 1816 IDIDAFDKEYKMAYDRLTPSQVKS--THNCDRPPSTGVMECRKTFGEP 1861
Score = 99.4 bits (246), Expect = 2e-20
Identities = 54/97 (55%), Positives = 67/97 (69%), Gaps = 3/97 (3%)
Query: 1110 ESSASLGSEWDLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYD 1169
ESSASL E LS+ +L S SS S+T FQ+ ++E+L+SSCS CR CD LV+D
Sbjct: 1406 ESSASL--EGSLSKFALPGKSEVTSSFNASNT-NIFQNYAMEVLISSCSRCRTCDCLVHD 1462
Query: 1170 EEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLDSR 1206
EEIMAGW DDSNLNTTCPFC F+P L+++ D R
Sbjct: 1463 EEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLR 1499
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 716 bits (1849), Expect = 0.0
Identities = 377/717 (52%), Positives = 481/717 (67%), Gaps = 21/717 (2%)
Query: 240 MGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLS 299
MGATIECW +TKYP+PVFSTFVLTG++ KVYGAA+QFYE + R LSE+Q LGLL+
Sbjct: 1 MGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMHLGLLT 60
Query: 300 AVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIH 359
VER + +++ + + I +LS WP F AFR FL F+Y+ SVSGPH LP+E HISHF+
Sbjct: 61 PVER--KMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQ 118
Query: 360 NVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLT 419
N+PFPSPQRPRILVQ+S +D L+L QPVS+PLPLSGA+F LL +LGPE TLLL VL
Sbjct: 119 NIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLL 178
Query: 420 EHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSY 479
E K+L+HSLRP +LT V EA+V+MIFP WQCPYIPLCPL LA VLSAP+PFIVG+ S Y
Sbjct: 179 ESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRY 238
Query: 480 FDLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGP 539
FDLHDPP DV+C+DLDTN L+ ++EKK ++ + LP++P K LL+TL LY QL +
Sbjct: 239 FDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKT 298
Query: 540 EEEASLEFLLTDYEAVCG---RRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGA 596
+E ++++ +T EA + +LE E+Q AFLRFMA +LKGYR +LRP+T+APS A
Sbjct: 299 QEGSAID--MTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKA 356
Query: 597 RDVDNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKV 656
D+LF QGFLKSR+R+ K Y+ L TQ+F +FIEECSF S + L FFD C+EK+
Sbjct: 357 TAADSLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSDKDTGLAFFDDCIEKL 416
Query: 657 HPEQ----------EKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGF 706
P++ + E T L+EL++ SE TVFI PPE P +G + +P+Y Y F
Sbjct: 417 FPDKGTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPEPPP-DDGKDLSPKYSYKYF 475
Query: 707 PELRAELFESLQEQPGALPVPGPSRSAPSSP--APRRTKQEMKVAQRMAQKSAAVPELWA 764
P L +LF+ QE S SP +RTKQE+K A ++A++ P WA
Sbjct: 476 PRLDLKLFDRPQELKLCFSRHPTGNSITKSPPLMAKRTKQEIKTAHKLAKRCYTNPPQWA 535
Query: 765 RCLLGHCYGLWFLCLPAYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCS 824
+CL HCY LWF+CLPAYVR + +V+AL AY VL +M V DEVCYRV+MQLC
Sbjct: 536 KCLFSHCYSLWFICLPAYVRVSHPKVRALQQAYDVLIKMRKTDVDPLDEVCYRVVMQLCG 595
Query: 825 HYGQPVLSVRVMLEMRQAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGA 884
+G PVL+VRV+ EM+ A I PN ITYGYYNK VLES WPS T G W K+RNVV G
Sbjct: 596 LWGHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWPSSTRSGIFLWTKVRNVVRGL 655
Query: 885 AQFRQPLRERQQQQQQQQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQT 941
AQFRQPL++ Q+ Q Q Q + E AE ++ R L +T
Sbjct: 656 AQFRQPLKKTVQRSQVSSISGGQSDQ-GYGSKDELIKDDAEIHVPEEQAARELITKT 711
Score = 168 bits (426), Expect = 3e-41
Identities = 98/230 (42%), Positives = 140/230 (60%), Gaps = 11/230 (4%)
Query: 1266 YLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGLVLASC 1325
YLSPLVLRKELESL+ENEG +V+ + HPIIFWNL+WYF+RL LPS LPGL+L S
Sbjct: 1451 YLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSE 1510
Query: 1326 DGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWR-VHSQIPQRVVWPGPV 1384
Q P L+ D V ++LLWD + PLYV WR +S+ ++
Sbjct: 1511 HCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFNSEKKSSLLSEEQQ 1570
Query: 1385 PASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAALGKD 1444
S L+E++ + + N V K + LL + + P G+ QR +YREILFL++ +LG++
Sbjct: 1571 ETS---TLVETIRQSIQHNNVLKPINLLSQQMKP---GMKRQRSLYREILFLSLVSLGRE 1624
Query: 1445 HVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAID-CRKCFGAP 1493
++DI AFD +Y A+N L+S + + R ++ P +++ CRKCFGAP
Sbjct: 1625 NIDIEAFDNEYGIAYNSLSSEILE---RLQKIDAPPSASVEWCRKCFGAP 1671
Score = 93.6 bits (231), Expect = 1e-18
Identities = 49/108 (45%), Positives = 66/108 (61%), Gaps = 6/108 (5%)
Query: 1145 FQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSVQTLD 1204
+Q+ ++E+L+SSCS CRAC +LVYDEEIMAGW DDSNLNT CPFC F+PLL+++ D
Sbjct: 1244 YQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKD 1303
Query: 1205 SRPSVPSPKSAGASGSKDAPVPGGPGPVLS---DRRLCLALDEPQLCN 1249
R S SG + G P+ + + + +L EP L N
Sbjct: 1304 LRGSASFFLKPSTSGDS---LQSGSIPLANESLEHKPVSSLAEPDLIN 1348
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 152 bits (383), Expect = 3e-36
Identities = 133/461 (28%), Positives = 210/461 (45%), Gaps = 49/461 (10%)
Query: 214 ELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYG 273
+++ R+P++D + P P+ + +FC P G W + P F VLT D+ Y
Sbjct: 26 KIIQRFPQKDWDDTPFPQGIELFCQPGG-----WQLSRERKQPTFFVVVLTDIDSDRHYC 80
Query: 274 AALQFYEAF-----PRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFP 328
+ L FYEA + E +A+ GL+ E V + +++ ++SR
Sbjct: 81 SCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAE---------VFAPKSLVLVSRLYYPE 131
Query: 329 AFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVS 388
FRA L +Y V + + LE+ I++ + P+ + L + D L+ P+
Sbjct: 132 IFRACLGLIYTVYVDSLN-VSLESLIANLCACL-VPAAGGSQKLFSLGAGDRQLIQTPLH 189
Query: 389 SPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLH 448
LP++G S L Q LG + ++L AVLTE+K+L HS L+ C AL S++FPL
Sbjct: 190 DSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLK 249
Query: 449 WQCPYIPLCPLVLADVLSAPVPFIVGIHSSY-FDLHDPPADVICVDLDTNTLFQTEEKKL 507
+ PYIP+ P L +VLS+P PFI+G+HS + D+H+ DVI DLD T+ E L
Sbjct: 250 YSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHE-LLDVIIADLDGGTIKIPECIHL 308
Query: 508 LS-PRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRARLEREV 566
S P L + L L + D + P S L++EV
Sbjct: 309 SSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALS-------------HSKMLDKEV 355
Query: 567 QGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHT 626
+ FLR A L +GYR L+ L + +E F FL R + +++L
Sbjct: 356 RAVFLRLFAQLFQGYRSCLQ-LIRIHAEPVIH----FHKTAFLGQRGLVENDFLTKVLSG 410
Query: 627 QMFSQFIEECSFGSARHAALEFFDSC----VEKVHPEQEKP 663
F+ F+ E + + + FD VE++ E+ P
Sbjct: 411 MAFAGFVSE---RGPPYRSCDLFDELVAFEVERIKVEENNP 448
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 128 bits (322), Expect = 4e-29
Identities = 117/437 (26%), Positives = 181/437 (41%), Gaps = 42/437 (9%)
Query: 212 EAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKV 271
+ ++L R+PE+D E P P+ + +FC P G W + P F VLT ++
Sbjct: 24 QGQILQRFPEKDWEDNPFPQGIELFCQPSG-----WQLCPERNPPTFFVAVLTDINSERH 78
Query: 272 YGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRA------------IA 319
Y A L F+E A S+ R E G GG+ S A +
Sbjct: 79 YCACLTFWEP---AEPSQETTRVEDATEREEEGDE-GGQTHLSPTAPAPSAQLFAPKTLV 134
Query: 320 VLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYD 379
++SR FR L +Y V G + + LE I + + P + + + D
Sbjct: 135 LVSRLDHTEVFRNSLGLIYAIHVEGLN-VCLENVIGNLL-TCTVPLAGGSQRTISLGAGD 192
Query: 380 NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEA 439
++ P++ LP+S S L + LG ++L A LTEHK+L S L C
Sbjct: 193 RQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRG 252
Query: 440 LVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPADVICVDLDTNTL 499
L++++FPL + Y+P+ P L +VLS P PFI+G+++++ DVI DLD T+
Sbjct: 253 LLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVADLDGGTV 312
Query: 500 FQTEEKKLLS-PRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGR 558
E + P L + + VL L + D + P S
Sbjct: 313 TIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTS-------------S 359
Query: 559 RARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHK 618
++E++ FLR A LL+GYR L + P R F FL R
Sbjct: 360 LKMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIR-----FHKAAFLGQRGLVEDD 414
Query: 619 LYSQLLHTQMFSQFIEE 635
++L F+ F+ E
Sbjct: 415 FLMKVLEGMAFAGFVSE 431
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 104 bits (259), Expect = 7e-22
Identities = 84/334 (25%), Positives = 148/334 (44%), Gaps = 46/334 (13%)
Query: 211 YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270
+++++L YP+ ++V + C+P G + QT P F +F++T G +
Sbjct: 55 FKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFR---TQTDNKDPQFHSFIITREDGSR 111
Query: 271 VYGAALQFYEAFPRARL--------------------SERQARALGLLSAVERGRA---- 306
YG L FYE ++ + L S+++ G
Sbjct: 112 TYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLL 171
Query: 307 ---------LGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSG-PHRLPLEAHISH 356
+ + ++I +++ P A + FL LY+ S P LPLE++I +
Sbjct: 172 KLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHN 231
Query: 357 FIHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLA 416
++ VP P P R L Y+ ++ +P S LPLS + + LG E + +
Sbjct: 232 ILYEVPLPPPGRS--LKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFTC 289
Query: 417 VLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIH 476
VL E ++L++S L +V E + +++FP WQ Y+P+ P L L APVP+++G+
Sbjct: 290 VLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQ 349
Query: 477 S------SYFDLHDPPADVICVDLDTNTLFQTEE 504
S S +L A++ VD+D + + EE
Sbjct: 350 SKEGTDRSKLEL-PQEANLCFVDIDNHFIELPEE 382
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 100 bits (250), Expect = 8e-21
Identities = 87/347 (25%), Positives = 151/347 (43%), Gaps = 51/347 (14%)
Query: 211 YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270
+++++L RYPE ++V + C+P G + Q P F F++T G +
Sbjct: 73 FKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFK---TQADPREPQFHAFIITREDGSR 129
Query: 271 VYGAALQFYEAFPRARLSERQARALGL-----------------LSAVERGRA------- 306
+G AL FYE ++ + S++E G
Sbjct: 130 TFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQ 189
Query: 307 ------LGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSG-PHRLPLEAHISHFIH 359
+ + + I +++ A R+ L L++ S P LPLE++I + ++
Sbjct: 190 RFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLY 249
Query: 360 NVPFPSPQRPRILVQMSPYDNLLLCQ-PVSSPLPLSGASFLQLLQSLGPELAITLLLAVL 418
VP P P R ++ S ++CQ P ++ LPL ++ + LG E L L
Sbjct: 250 EVPLPPPGRS---LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCAL 306
Query: 419 TEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSS 478
E ++L++S L +V E + +++FP WQ Y+P+ P L L APVP+++G+HS+
Sbjct: 307 LEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSN 366
Query: 479 YFD----LHDPPADVIC-VDLDTNTLFQTEEKKLLSPRTLPRRPYKV 520
D L P +C VD+D + + P LP+ P K+
Sbjct: 367 GLDDRSKLELPQEANLCFVDIDNHF--------IELPEDLPQFPNKL 405
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 88.2 bits (217), Expect = 5e-17
Identities = 101/443 (22%), Positives = 183/443 (41%), Gaps = 81/443 (18%)
Query: 211 YEAELLGRYPEEDNEAFPLP-------ESVPVFCLPMGATIECWPAQTKYPVPVFSTFVL 263
Y EL ++P + +F +++P FC P + W ++ FS FVL
Sbjct: 582 YVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFP---DAKDWVPVQQFTSETFS-FVL 637
Query: 264 TGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSR 323
TG G + +G + GG+ R ++SR
Sbjct: 638 TGEDGSRRFGYCRRLLP---------------------------GGKGKRLPEVYCIVSR 670
Query: 324 WPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDN--- 380
F F L + + P L + + PFP+ + ++ P
Sbjct: 671 LGCFSLFSRILDEVEKRRGISP---ALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEV 727
Query: 381 LLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEAL 440
+ LC+P+ S L F L SL + + ++L E +++ + + +L+ C A+
Sbjct: 728 IELCRPLDSRL--EHVDFESLFSSLSVRHLVCVFASLLLERRVIFIADKLSILSKCCHAM 785
Query: 441 VSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDL--HDPPADVICVDL-DTN 497
V++I+P WQ YIP+ P + D++ +P PF++G+ SS L P +V+ VDL ++
Sbjct: 786 VALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSR 845
Query: 498 TLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCG 557
L Q +++ + PR L L ++ +Q ++ ++E L+ G
Sbjct: 846 FLRQMDDEDSILPRKLQ--------VALEHILEQRNE-LACEQDEGPLD----------G 886
Query: 558 RR----ARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRE 613
R + L V AF+RF ++ Y +FL + G R+ + + F K+
Sbjct: 887 RHGPESSPLNEVVSEAFVRFFVEIVGHYSLFL-------TSGERE-ERTLQREAFRKAVS 938
Query: 614 RSSHKLYSQL-LHTQMFSQFIEE 635
S + + ++ + TQMF FI+E
Sbjct: 939 SKSLRHFLEVFMETQMFRGFIQE 961
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 85.9 bits (211), Expect = 3e-16
Identities = 101/428 (23%), Positives = 176/428 (41%), Gaps = 47/428 (10%)
Query: 218 RYPEEDNEAFPLPE---SVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGA 274
R PE ++ A P ++P C P G + P + VLT G++ YG
Sbjct: 24 RAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKED-----CVHFLVLTDVCGNRTYGV 78
Query: 275 ALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFL 334
Q+Y L + G + R G V A+ V+SR+P + + + L
Sbjct: 79 VAQYYRP-----LHDEYCFYNG-----KTHRECPGCFVPF--AVCVVSRFPYYNSLKDCL 126
Query: 335 TFLYRYSVSGPHRLPLEAHISHF---IHNVPFPSPQRPRILVQMSPYDNLLLCQPVSSPL 391
+ L + +++HI F + +P P P ++ M ++L
Sbjct: 127 SCLLAL-LKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQ-IVLPARADPES 184
Query: 392 PLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQC 451
P+ L PE + +L +LTE +++ S LLT V E ++ ++PL WQ
Sbjct: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
Query: 452 PYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPAD-VICVDLDTNTLFQTEEKKLLSP 510
P++P+ + D + AP F++G H +F+ AD ++ +++D ++ T K
Sbjct: 245 PFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSI--TYSKSTDDN 302
Query: 511 RTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDY-EAVCGRRA---RLEREV 566
+P P LLA T Q++ E A+ TD E RR+ +L ++
Sbjct: 303 VDIPDVP---LLAAQT-FIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQI 358
Query: 567 QGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHT 626
Q L+ + + + + L +F + FLK+R H+ Y Q+L T
Sbjct: 359 QQTTLQLLVSIFRDVKNHL-----------NYEHRVFNSEEFLKTRAPGDHQFYKQVLDT 407
Query: 627 QMFSQFIE 634
MF F++
Sbjct: 408 YMFHSFLK 415
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
Query: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
G YG + FY +F + E+ +
Sbjct: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
Query: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
Query: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
RL +E S +H++ P P
Sbjct: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
Query: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
Query: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
Query: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
F P DV VDLD+N + ++L
Sbjct: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 77.4 bits (189), Expect = 1e-13
Identities = 101/449 (22%), Positives = 180/449 (40%), Gaps = 88/449 (19%)
Query: 205 KANTLVYEAELLGRYPEEDNEAFPLPES-------VPVFCLPMGATIECWPAQTKYPVPV 257
K + + Y +++ ++P +D+ + + +P FC P W ++
Sbjct: 445 KPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKD---WMPTSELKSET 501
Query: 258 FSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRA 317
FS FVLTG G + +G + G+ R
Sbjct: 502 FS-FVLTGEDGSRWFGYCKKLLPV---------------------------GKGKRLPEV 533
Query: 318 IAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQ 374
++SR F F L + + P A + F+ +V PFP+P R +
Sbjct: 534 YCMVSRLGCFNLFSKILDEVEKRREMSP------ALVYPFMRSVMEAPFPAPGRTITVKS 587
Query: 375 MSPY---DNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPD 431
P +++ LC+P+ S L F L + L I + ++L E +++ +
Sbjct: 588 YLPGAGDESIELCRPLDSRL--EHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLS 645
Query: 432 LLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHS-SYFDLHD-PPADV 489
L+ A+V+ ++P WQ YIP+ P + D++ +P PF++GI S S L D P +V
Sbjct: 646 TLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEV 705
Query: 490 ICVDLDTNTLFQ--TEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEF 547
+ VDL + Q ++E ++L P+ L A L + ++ ++ T E+ S +
Sbjct: 706 LIVDLCADKFLQEVSDEDEILPPK---------LQAALMQILEERNEILT-QEQNFSQDV 755
Query: 548 LLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQG 607
L V AF+RF L+ Y + + + + +F +
Sbjct: 756 TLNSL-------------VSEAFVRFFVELVGHYSLNMTVTERG--------ERVFQREP 794
Query: 608 FLKSR-ERSSHKLYSQLLHTQMFSQFIEE 635
F KS RS + TQMF+ FI++
Sbjct: 795 FRKSHTSRSVRHFLDLFMETQMFAGFIQD 823
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 75.5 bits (184), Expect = 4e-13
Identities = 99/473 (20%), Positives = 186/473 (39%), Gaps = 96/473 (20%)
Query: 211 YEAELLGRYPEEDN-------EAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVL 263
YE + ++P+ +N E L +++P+FC P G W + T+YP FS FVL
Sbjct: 71 YEPIITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNE---WASLTEYPRETFS-FVL 126
Query: 264 TGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSR 323
T G + G + A P RL + ++S
Sbjct: 127 TNVDGSRKIGYCRRLLPAGPGPRLP---------------------------KVYCIISC 159
Query: 324 WPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQMSPYDN 380
F F L V H++ + A I F+ + FP+P + L P
Sbjct: 160 IGCFGLFSKILD-----EVEKRHQISM-AVIYPFMQGLREAAFPAPGKTVTLKSFIPDSG 213
Query: 381 ---LLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVC 437
+ L +P+ S L F LL L E + + + + E K++ + L+
Sbjct: 214 TEFISLTRPLDSHL--EHVDFSSLLHCLSFEQILQIFASAVLERKIIFLAEGLSTLSQCI 271
Query: 438 EALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICVDLD 495
A ++++P W YIP+ P L + P PF+VG+ + + P +V+ V+L
Sbjct: 272 HAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFQQEVMDSPMEEVLLVNLC 331
Query: 496 TNTLFQT--EEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYE 553
T + +EK +L P K+ L +L Q +++ T +
Sbjct: 332 EGTFLMSVGDEKDILPP--------KLQDDILDSLGQGINELKTAEQ------------- 370
Query: 554 AVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS-R 612
+ V G F++F ++ Y +++ +A +G F + F K+
Sbjct: 371 --------INEHVSGPFVQFFVKIVGHYASYIK--REANGQGH------FQERSFCKALT 414
Query: 613 ERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQEKPEP 665
+++ + + + TQ+FS FI+E +++ +F + + ++++ +P
Sbjct: 415 SKTNRRFVKKFVKTQLFSLFIQEAE--KSKNPPAGYFQQKILEYEEQKKQKKP 465
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 72.0 bits (175), Expect = 4e-12
Identities = 77/323 (23%), Positives = 126/323 (39%), Gaps = 57/323 (17%)
Query: 318 IAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFI---HNVPFPSPQRPRILVQ 374
+ +LS P F + L L Y LE ++ + +N P P P V
Sbjct: 95 LCILSYLPWFEVYYKLLNTLADYLAK-----ELENDLNETLRSLYNHPVPKANTP---VN 146
Query: 375 MSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLT 434
+S + + P + + ++ + L ++L E ++++ S + LT
Sbjct: 147 LSVHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLT 206
Query: 435 SVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICV 492
+ ++++P++WQ YIP+ P L D AP+P+++GIHSS + + DV+ +
Sbjct: 207 ACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVML 266
Query: 493 DLDTNTLFQTEEKKLLSP-RTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTD 551
++DTNT L SP L P V+ A L +Q T G
Sbjct: 267 NVDTNT--------LESPFSDLNNLPSDVVSALKNKLKKQSTATGDG------------- 305
Query: 552 YEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS 611
V AFLR A L YR LR P F + F+K
Sbjct: 306 --------------VARAFLRAQAALFGSYRDALRYKPGEPI--------TFCEESFVKH 343
Query: 612 RERSSHKLYSQLLHTQMFSQFIE 634
R + ++ Q+F QFI+
Sbjct: 344 RSSVMKQFLETAINLQLFKQFID 366
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 71.6 bits (174), Expect = 5e-12
Identities = 105/455 (23%), Positives = 184/455 (40%), Gaps = 78/455 (17%)
Query: 211 YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270
Y+ L R ++ EA +++P FC P + W ++Y FS F+LTG G +
Sbjct: 720 YQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDGSR 775
Query: 271 VYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAF 330
+G + + G+ R V+SR F F
Sbjct: 776 RFGYCRRLLPS---------------------------GKGPRLPEVYCVISRLGCFGLF 808
Query: 331 RAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQMSP---YDNLLLC 384
L + R R A + F+ ++ PFP+P + + P + L L
Sbjct: 809 SKVLDEVER------RRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELR 862
Query: 385 QPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMI 444
+P+ S L F L L I + ++L E +++ + + L+S A+V+++
Sbjct: 863 RPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALL 920
Query: 445 FPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICVDLDTNTLF-Q 501
+P WQ +IP+ P + D++ P PF+VG+ SS P + + V+L ++ Q
Sbjct: 921 YPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQ 980
Query: 502 TEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRAR 561
+++ L PR L A L ++ ++ + + +D + C
Sbjct: 981 MDDEDTLLPRKLQ--------AALEQALERKNELISQDSD--------SDSDDECNTLNG 1024
Query: 562 LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS-RERSSHKLY 620
L EV F+RF + Y +F LTQ+ +G R F + F KS +S +
Sbjct: 1025 LVSEV---FIRFFVETVGHYSLF---LTQS-EKGER----AFQREAFRKSVASKSIRRFL 1073
Query: 621 SQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEK 655
+ +QMF+ FI++ R L F+ VE+
Sbjct: 1074 EVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 1106
Score = 32.0 bits (71), Expect = 4.6
Identities = 60/248 (24%), Positives = 88/248 (35%), Gaps = 46/248 (18%)
Query: 960 KSGSLGSARGAQPTVEAGVAHMIEALGVLEPRGS--PVPWHDGSLSDLSLTGEEPLPGGS 1017
K+G+LGS +P A V+ A+GV G P P +GS S G+
Sbjct: 316 KTGTLGSLE--EPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGSTKP---------GT 364
Query: 1018 PGGSGSALSAQSTEALEGLSGRGPKAG------GRQDEAGTPRRGLGARLQQLLTPSRHS 1071
PG S S+ S +L+ PK ++ P GL S
Sbjct: 365 PGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPP-----------S 413
Query: 1072 PASRIPPPELPPDLPPPARRSPMDSLLHPRERP-GSTASESSASL-----------GSEW 1119
P PPP PP RR D H + + S E ++SL G+E
Sbjct: 414 PTPAAPPPLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTEN 473
Query: 1120 DLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYD--EEIMAGWA 1177
S S L + + D P ++P ++ L S R L + + + W+
Sbjct: 474 QPKFGSKSTLEENAYEDIVGDLPK--ENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWS 531
Query: 1178 PDDSNLNT 1185
P D N+
Sbjct: 532 PQDRKYNS 539
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 71.6 bits (174), Expect = 5e-12
Identities = 105/455 (23%), Positives = 184/455 (40%), Gaps = 78/455 (17%)
Query: 211 YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270
Y+ L R ++ EA +++P FC P + W ++Y FS F+LTG G +
Sbjct: 720 YQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDGSR 775
Query: 271 VYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAF 330
+G + + G+ R V+SR F F
Sbjct: 776 RFGYCRRLLPS---------------------------GKGPRLPEVYCVISRLGCFGLF 808
Query: 331 RAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQMSP---YDNLLLC 384
L + R R A + F+ ++ PFP+P + + P + L L
Sbjct: 809 SKVLDEVER------RRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELR 862
Query: 385 QPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMI 444
+P+ S L F L L I + ++L E +++ + + L+S A+V+++
Sbjct: 863 RPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALL 920
Query: 445 FPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICVDLDTNTLF-Q 501
+P WQ +IP+ P + D++ P PF+VG+ SS P + + V+L ++ Q
Sbjct: 921 YPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQ 980
Query: 502 TEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRAR 561
+++ L PR L A L ++ ++ + + +D + C
Sbjct: 981 MDDEDTLLPRKLQ--------AALEQALERKNELISQDSD--------SDSDDECNTLNG 1024
Query: 562 LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS-RERSSHKLY 620
L EV F+RF + Y +F LTQ+ +G R F + F KS +S +
Sbjct: 1025 LVSEV---FIRFFVETVGHYSLF---LTQS-EKGER----AFQREAFRKSVASKSIRRFL 1073
Query: 621 SQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEK 655
+ +QMF+ FI++ R L F+ VE+
Sbjct: 1074 EVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 1106
Score = 32.0 bits (71), Expect = 4.6
Identities = 60/248 (24%), Positives = 88/248 (35%), Gaps = 46/248 (18%)
Query: 960 KSGSLGSARGAQPTVEAGVAHMIEALGVLEPRGS--PVPWHDGSLSDLSLTGEEPLPGGS 1017
K+G+LGS +P A V+ A+GV G P P +GS S G+
Sbjct: 316 KTGTLGSLE--EPAGGASVSAGSRAVGVAGVAGEAGPPPEREGSGSTKP---------GT 364
Query: 1018 PGGSGSALSAQSTEALEGLSGRGPKAG------GRQDEAGTPRRGLGARLQQLLTPSRHS 1071
PG S S+ S +L+ PK ++ P GL S
Sbjct: 365 PGNSPSSQRLPSKSSLDPAVNPVPKPKRTFEYEADKNPKSKPSNGLPP-----------S 413
Query: 1072 PASRIPPPELPPDLPPPARRSPMDSLLHPRERP-GSTASESSASL-----------GSEW 1119
P PPP PP RR D H + + S E ++SL G+E
Sbjct: 414 PTPAAPPPLPSTPAPPVTRRPKKDMRGHRKSQSRKSFEFEDASSLQSLYPSSPTENGTEN 473
Query: 1120 DLSESSLSNLSLRRSSERLSDTPGSFQSPSLEILLSSCSLCRACDSLVYD--EEIMAGWA 1177
S S L + + D P ++P ++ L S R L + + + W+
Sbjct: 474 QPKFGSKSTLEENAYEDIVGDLPK--ENPYEDVDLKSRRAGRKSQQLSENSLDSLHRMWS 531
Query: 1178 PDDSNLNT 1185
P D N+
Sbjct: 532 PQDRKYNS 539
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 71.6 bits (174), Expect = 5e-12
Identities = 105/455 (23%), Positives = 184/455 (40%), Gaps = 78/455 (17%)
Query: 211 YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270
Y+ L R ++ EA +++P FC P + W ++Y FS F+LTG G +
Sbjct: 300 YQFPKLDRPTKQMREAEERLKAIPQFCFP---DAKDWLPVSEYSSETFS-FMLTGEDGSR 355
Query: 271 VYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFPAF 330
+G + + G+ R V+SR F F
Sbjct: 356 RFGYCRRLLPS---------------------------GKGPRLPEVYCVISRLGCFGLF 388
Query: 331 RAFLTFLYRYSVSGPHRLPLEAHISHFIHNV---PFPSPQRPRILVQMSP---YDNLLLC 384
L + R R A + F+ ++ PFP+P + + P + L L
Sbjct: 389 SKVLDEVER------RRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGAGNEVLELR 442
Query: 385 QPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMI 444
+P+ S L F L L I + ++L E +++ + + L+S A+V+++
Sbjct: 443 RPMDSRL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALL 500
Query: 445 FPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFD--LHDPPADVICVDLDTNTLF-Q 501
+P WQ +IP+ P + D++ P PF+VG+ SS P + + V+L ++ Q
Sbjct: 501 YPFSWQHTFIPVLPASMIDIVCCPTPFLVGLLSSSLPKLKELPVEEALMVNLGSDRFIRQ 560
Query: 502 TEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRAR 561
+++ L PR L A L ++ ++ + + +D + C
Sbjct: 561 MDDEDTLLPRKLQ--------AALEQALERKNELISQDSD--------SDSDDECNTLNG 604
Query: 562 LEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKS-RERSSHKLY 620
L EV F+RF + Y +F LTQ+ +G R F + F KS +S +
Sbjct: 605 LVSEV---FIRFFVETVGHYSLF---LTQS-EKGER----AFQREAFRKSVASKSIRRFL 653
Query: 621 SQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEK 655
+ +QMF+ FI++ R L F+ VE+
Sbjct: 654 EVFMESQMFAGFIQDRELRKCRAKGL--FEQRVEQ 686
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 69.3 bits (168), Expect = 3e-11
Identities = 61/227 (26%), Positives = 96/227 (42%), Gaps = 46/227 (20%)
Query: 411 ITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVP 470
+ L ++L E ++++ S + LT+ ++++P++WQ YIP+ P L D AP+P
Sbjct: 203 LQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMP 262
Query: 471 FIVGIHSSYFD--LHDPPADVICVDLDTNTLFQTEEKKLLSP-RTLPRRPYKVLLATLTN 527
+++GIHSS + + DV+ +++DTNT L SP L P V+ A
Sbjct: 263 YLIGIHSSLIERVKNKSLEDVVMLNVDTNT--------LESPFSDLNNLPSDVVSALKNK 314
Query: 528 LYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRP 587
L +Q T G V AFLR A L YR LR
Sbjct: 315 LKKQSTATGDG---------------------------VARAFLRAQAALFGSYRDALRY 347
Query: 588 LTQAPSEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIE 634
P F + F+K R + ++ Q+F QFI+
Sbjct: 348 KPGEPI--------TFCEESFVKHRSSVMKQFLETAINLQLFKQFID 386
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 68.6 bits (166), Expect = 4e-11
Identities = 47/188 (25%), Positives = 85/188 (45%), Gaps = 7/188 (3%)
Query: 314 SRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILV 373
++ +LS P F F L L Y+ E + +H +P P P + V
Sbjct: 93 AKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNE--LLETLHKLPIPDPG---VSV 147
Query: 374 QMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLL 433
+S + + P + + ++ + L ++L E ++L+ + L
Sbjct: 148 HLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTL 207
Query: 434 TSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPA--DVIC 491
T+ +M++P++WQ YIP+ P L D AP+P+++GIH S + A DV+
Sbjct: 208 TACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI 267
Query: 492 VDLDTNTL 499
+++DTNTL
Sbjct: 268 LNVDTNTL 275
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 68.6 bits (166), Expect = 4e-11
Identities = 47/188 (25%), Positives = 85/188 (45%), Gaps = 7/188 (3%)
Query: 314 SRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILV 373
++ +LS P F F L L Y+ E + +H +P P P + V
Sbjct: 93 AKSCFCILSYLPWFEVFYKLLNILADYTTKRQENQWNE--LLETLHKLPIPDPG---VSV 147
Query: 374 QMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLL 433
+S + + P + + ++ + L ++L E ++L+ + L
Sbjct: 148 HLSVHSYFTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTL 207
Query: 434 TSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPA--DVIC 491
T+ +M++P++WQ YIP+ P L D AP+P+++GIH S + A DV+
Sbjct: 208 TACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGIHLSLMEKVRNMALDDVVI 267
Query: 492 VDLDTNTL 499
+++DTNTL
Sbjct: 268 LNVDTNTL 275
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 62.0 bits (149), Expect = 4e-09
Identities = 105/438 (23%), Positives = 166/438 (37%), Gaps = 83/438 (18%)
Query: 208 TLVYEAELLGRYPEE--DNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
+L + +L ++P + D EA + VP FC P E P TF LT
Sbjct: 24 SLQEDPPILRQFPPDFRDQEAMQM---VPKFCFPFDVERE-----PPSPAVQHFTFALTD 75
Query: 266 AAGDKVYGAALQFYEAFPRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWP 325
AG++ +G RL L +LS + + + L
Sbjct: 76 LAGNRRFGFC----------RLRAGTQSCLCILSHLPWFEVF----YKLLNTVGDLLAQD 121
Query: 326 AFPAFRAFLTFLYRYSVSGPHR---LPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLL 382
L L++ S+SGP L L + ++ P P R L
Sbjct: 122 QVTEAEELLQNLFQQSLSGPQASVGLELGSGVT-VSSGQGIPPPTRGN--------SKPL 172
Query: 383 LC--QPVSSPLPL--SGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCE 438
C P S LP + +L+ ++ E + L A+L E ++L+ + + LTS
Sbjct: 173 SCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVH 232
Query: 439 ALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYFDLHDPPA--DVICVDLDT 496
A ++++P+ W+ IP P L D AP+P+++G+H+S + A DV+ +++D
Sbjct: 233 ASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDA 292
Query: 497 NTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVC 556
NTL E + LP P V L L +L + P E S
Sbjct: 293 NTL----ETTFNDVQALP--PDVVSLLRL-----RLRKVALAPGEGVS------------ 329
Query: 557 GRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSS 616
RL FL+ A L GYR L +P + + +F Q
Sbjct: 330 ----RL-------FLKAQALLFGGYR---DALVCSPGQPVTFSEEVFLAQ----KPGAPL 371
Query: 617 HKLYSQLLHTQMFSQFIE 634
+ + +H Q+F QFIE
Sbjct: 372 QAFHRRAVHLQLFKQFIE 389
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,342,006
Number of Sequences: 37866
Number of extensions: 4303437
Number of successful extensions: 34480
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 241
Number of HSP's successfully gapped in prelim test: 489
Number of HSP's that attempted gapping in prelim test: 24239
Number of HSP's gapped (non-prelim): 6639
length of query: 1496
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1381
effective length of database: 13,892,928
effective search space: 19186133568
effective search space used: 19186133568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.