BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|148234215 guanylate binding protein 4-like [Homo sapiens] (638 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|148234215 guanylate binding protein 4-like [Homo sapiens] 1258 0.0 gi|31377634 guanylate binding protein 4 [Homo sapiens] 959 0.0 gi|157671915 guanylate binding protein family, member 6 [Homo sa... 868 0.0 gi|38327558 guanylate binding protein 2, interferon-inducible [H... 650 0.0 gi|166706903 guanylate binding protein 1, interferon-inducible, ... 649 0.0 gi|112382372 guanylate binding protein 3 [Homo sapiens] 647 0.0 gi|197333737 guanylate-binding protein 5 [Homo sapiens] 593 e-169 gi|16418425 guanylate-binding protein 5 [Homo sapiens] 593 e-169 gi|169160863 PREDICTED: similar to guanylate-binding protein 5 [... 102 1e-21 gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens] 73 9e-13 gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens] 73 9e-13 gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens] 71 3e-12 gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens] 71 3e-12 gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens] 71 3e-12 gi|45827806 atlastin 3 [Homo sapiens] 67 7e-11 gi|58530840 desmoplakin isoform I [Homo sapiens] 54 6e-07 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 54 6e-07 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 54 6e-07 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 54 6e-07 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 54 6e-07 gi|71061468 centromere protein E [Homo sapiens] 53 1e-06 gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 52 2e-06 gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 51 4e-06 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 50 6e-06 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 50 6e-06 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 50 6e-06 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 50 6e-06 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 50 6e-06 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 50 6e-06 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 50 6e-06 >gi|148234215 guanylate binding protein 4-like [Homo sapiens] Length = 638 Score = 1258 bits (3254), Expect = 0.0 Identities = 638/638 (100%), Positives = 638/638 (100%) Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG Sbjct: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV Sbjct: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120 Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV Sbjct: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180 Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI Sbjct: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240 Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL Sbjct: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300 Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE Sbjct: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360 Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES Sbjct: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420 Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA Sbjct: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480 Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN Sbjct: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540 Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVA 600 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVA Sbjct: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVA 600 Query: 601 GSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS 638 GSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS Sbjct: 601 GSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS 638 >gi|31377634 guanylate binding protein 4 [Homo sapiens] Length = 640 Score = 959 bits (2480), Expect = 0.0 Identities = 484/622 (77%), Positives = 547/622 (87%), Gaps = 1/622 (0%) Query: 3 SEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKN 62 SE M P+CL EN + L VNS+ALEIL I+QPVVVVAIVGLYRTGKSYLMN+LAGK Sbjct: 18 SESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKR 77 Query: 63 KGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLL 122 GFPLG TV+SETKGIWMWCVPH SKPNHTL+LLDTEGLGD+EKS+PK+DSWIFALAVLL Sbjct: 78 NGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLL 137 Query: 123 SSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRD 182 SSSFVYNS+ TINHQALEQLHYVTEL ELIRAKSCPRPDE EDSSEF SFFPDFIWTVRD Sbjct: 138 SSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRD 197 Query: 183 FTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPIND 242 FTLELKLDG+PITEDEYLENALKLI GKNP+IQNSN PRE IRHFF K+KCFVFDRP ND Sbjct: 198 FTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTND 257 Query: 243 KKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDA 302 K+ L H++EV E+ L+ +F MQS+NFCSYIFTHAKTKTLREGI+VTG RLG LV TY+DA Sbjct: 258 KQYLNHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDA 317 Query: 303 INSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCERE 362 INSGA PCLENA+ LAQ EN AAVQRAA+HYSQQMAQQ+R PTDTLQELLDVHA CERE Sbjct: 318 INSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACERE 377 Query: 363 AIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESIS 422 AIAVFME+SFKD++ EFQKKLVDT+EKKK DFVLQNEEASAKYCQAELKRLSE LTESI Sbjct: 378 AIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESIL 437 Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482 RG F VPGGHN+YLE KK++E DY LVPRKGVKA+EVLQ+FLQSQVV+EESILQSDKALT Sbjct: 438 RGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALT 497 Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYM 542 AGEKAIAA++A KEAAEKEQELLR+KQKEQQQMMEAQERSFQE +AQ++KK+E EREN + Sbjct: 498 AGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLL 557 Query: 543 RELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVAGS 602 RE ++L HK+KV EE+L E F++ E LN+EIN+LKE+IE+ +NE+ + +ILD+A + Sbjct: 558 REHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLRLL-KILDMASN 616 Query: 603 IFIAALPGAAKLVDLGMKILSS 624 I I LPGA+KL+ +G K L S Sbjct: 617 IMIVTLPGASKLLGVGTKYLGS 638 >gi|157671915 guanylate binding protein family, member 6 [Homo sapiens] Length = 633 Score = 868 bits (2244), Expect = 0.0 Identities = 437/632 (69%), Positives = 515/632 (81%) Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 M S M PVCL EN L+VN +A++IL I+QPVVVVAIVGLYRTGKSYLMN LAG Sbjct: 1 MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAG 60 Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120 +N GFPLG TV+SETKGIWMWCVPHPSKPNHTL+LLDTEGLGD+EK DPK+DSWIFALAV Sbjct: 61 QNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAV 120 Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180 LL S+FVYNSM TINHQALEQLHYVTELTELI+AKS PRPD VEDS+EFVSFFPDF+WTV Sbjct: 121 LLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTV 180 Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240 RDFTLELKL+GHPITEDEYLENALKLI G NP++Q SN PRE IR FFPK+KCFVFDRP Sbjct: 181 RDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPT 240 Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300 NDK LL ++E+V E QLD FQ Q+ FCSYIFTHA+TKTLREGI VTGNRLG L TY+ Sbjct: 241 NDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYV 300 Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360 +AINSGA PCLENA+ LAQ ENSAAVQRAA++YSQQMAQ+V+ PTDTLQELLD+HA CE Sbjct: 301 EAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACE 360 Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420 REAIA+FME+SFKD++QEFQKK ++T KK DF+LQNEE+S +YCQA+L LS+ L ES Sbjct: 361 REAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMES 420 Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480 IS G+F VPGGH +Y+E K++IEQDY VPRKGVKA EV Q FL+SQ+VIEESILQSDKA Sbjct: 421 ISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKA 480 Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540 LT EKA+A +AKKEAAEKEQELL+QK +EQQQ MEAQ++S +ENIAQLK+K++ ERE+ Sbjct: 481 LTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREH 540 Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDVA 600 +RE ML H KV + L EGFK+ +E +N EI++ K I+ +N++ ++ LD Sbjct: 541 LLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNL 600 Query: 601 GSIFIAALPGAAKLVDLGMKILSSLCNRLRNP 632 A L AKL+ G+K +SSL + + P Sbjct: 601 ADELTAILSAPAKLIGHGVKGVSSLFKKHKLP 632 >gi|38327558 guanylate binding protein 2, interferon-inducible [Homo sapiens] Length = 591 Score = 650 bits (1677), Expect = 0.0 Identities = 326/575 (56%), Positives = 435/575 (75%), Gaps = 1/575 (0%) Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 MA EI++PGP+ L +NTKG LVVN EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG Sbjct: 1 MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120 K GF LG TVKS TKGIWMWCVPHP KP HTL+LLDTEGLGD+EK D ++DSWIFALA+ Sbjct: 61 KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI 120 Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180 LLSS+FVYNSMGTIN QA++QLHYVTELT+ I+A S P + V+DS++FVSFFP F+WT+ Sbjct: 121 LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL 180 Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240 RDFTLEL++DG PIT D+YLE +LKL G + + ++ N PR IR FFPK+KCFVFD P Sbjct: 181 RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA 240 Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300 KK L H+E+++E++L+ +F Q FCSYI +H+ KTL GI V G RL LV TY+ Sbjct: 241 -PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYV 299 Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360 +AI+SG PC+ENA+ LAQ ENSAAV++A HY QQM Q+V+ PT+TLQELLD+H E Sbjct: 300 NAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSE 359 Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420 REAI VFM+ SFKD Q FQ+KL +E +++DF QN +AS+ C A L+ + L E Sbjct: 360 REAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEED 419 Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480 + +GTF PGG+ ++ + ++++ Y VPRKG++A EVL+ +L+S+ + +++LQ+D++ Sbjct: 420 VKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQS 479 Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540 L+ EKAI ++ K E+AE +++L + QK+ ++MME +E+S+QE++ QL +KMER+R Sbjct: 480 LSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQ 539 Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEI 575 M E K L+ K++ E LL EGF+ + L ++I Sbjct: 540 LMAEQEKTLALKLQEQERLLKEGFENESKRLQKDI 574 >gi|166706903 guanylate binding protein 1, interferon-inducible, 67kDa [Homo sapiens] Length = 592 Score = 649 bits (1673), Expect = 0.0 Identities = 324/584 (55%), Positives = 440/584 (75%), Gaps = 3/584 (0%) Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 MASEIHM GP+CL ENT G L+ N EAL+ILSAITQP+VVVAIVGLYRTGKSYLMNKLAG Sbjct: 1 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG 60 Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120 K KGF LG TV+S TKGIWMWCVPHP KP H L+LLDTEGLGD+EK D ++DSWIFALAV Sbjct: 61 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV 120 Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCP--RPDEVEDSSEFVSFFPDFIW 178 LLSS+FVYNS+GTIN QA++QL+YVTELT IR+KS P +EVEDS++FVSFFPDF+W Sbjct: 121 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW 180 Query: 179 TVRDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDR 238 T+RDF+L+L+ DG P+T DEYL +LKL G + + + N PR IR FFPK+KCFVFDR Sbjct: 181 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR 240 Query: 239 PINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVET 298 P++ +KL +E++++++LD F Q +FCSYIF+++KTKTL GI V G RL LV T Sbjct: 241 PVHRRKLA-QLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLT 299 Query: 299 YLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAV 358 Y++AI+SG PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ PT+TLQELLD+H Sbjct: 300 YVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRD 359 Query: 359 CEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLT 418 EREAI VF+ SFKD FQK+L +EKK++DF QN+EAS+ C A L+ + L Sbjct: 360 SEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLE 419 Query: 419 ESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSD 478 E + G + PGG+ ++++ + +++ Y PRKG++A+E+LQ++L+S+ + ++ILQ+D Sbjct: 420 EEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTD 479 Query: 479 KALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER 538 + LT EK I ++ K E+A+ ++L++ Q++ +QMME +ERS+QE++ QL +KME +R Sbjct: 480 QTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDR 539 Query: 539 ENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQI 582 ++E + L+ K++ E+LL EGF++ + EI L+ ++ Sbjct: 540 VQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKM 583 >gi|112382372 guanylate binding protein 3 [Homo sapiens] Length = 595 Score = 647 bits (1668), Expect = 0.0 Identities = 325/583 (55%), Positives = 432/583 (74%), Gaps = 1/583 (0%) Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 MA EIHM GP+CL ENT G LV N EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG Sbjct: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120 KNKGF LG TVKS TKGIWMWCVPHP KP HTL+LLDTEGLGD++K D ++DSWIF LAV Sbjct: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120 Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180 LLSS+ VYNSMGTIN QA++QL+YVTELT IR+KS P +E EDS++FVSFFPDF+WT+ Sbjct: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180 Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240 RDF+L+L+ DG P+T DEYLE +LKL G + + +N N PR IR FFPK+KCFVFD PI Sbjct: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240 Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300 + +K L +E++++++LD F Q +FCSYIF+++KTKTL GI V G RL LV TY+ Sbjct: 241 HRRK-LAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYI 299 Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360 +AI+ G PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ P +TLQELLD+H V E Sbjct: 300 NAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE 359 Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420 REA V+M+ SFKD FQKKL ++KK++DF QN+EAS+ C A L+ + L E Sbjct: 360 REATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEE 419 Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480 + G + PGG+ ++++ + +E+ Y PRKG++A+E+LQ++L+S+ + ++ILQ+D+ Sbjct: 420 VKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQI 479 Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540 LT EK I + K E+A+ +++ + Q + QQMME +E+S+QE++ QL +KMERER Sbjct: 480 LTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQ 539 Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIE 583 + E K L+ K++ +L E + L EI +L++ ++ Sbjct: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582 >gi|197333737 guanylate-binding protein 5 [Homo sapiens] Length = 586 Score = 593 bits (1529), Expect = e-169 Identities = 307/592 (51%), Positives = 415/592 (70%), Gaps = 8/592 (1%) Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 MA EIHM P+CL EN L VN EALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG Sbjct: 1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120 KNKGF + TV+S TKGIW+WCVPHP+ PNHTL+LLDTEGLGD+EK+D K+D IFALA+ Sbjct: 61 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120 Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180 LLSS+FVYN++ I+ A++ LH VTELT+L++A++ P D VED ++ SFFPD +WT+ Sbjct: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180 Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240 RDF L L++DG +T DEYLEN+L+ G + ++QN N PR I+ FFPK+KCF+FD P Sbjct: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240 Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300 + KK L +E + +D+L+ F Q FCSYIF+H+ TKTL GI+V G+RL LV TY+ Sbjct: 241 HQKK-LAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYV 299 Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360 +AI+SG PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ P +TLQELLD+H E Sbjct: 300 NAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE 359 Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420 REAI VFM+ SFKD Q FQK+L ++ K+ D +N EAS+ YC A LK + L E+ Sbjct: 360 REAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEA 419 Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480 + +G + PGGHN++++ ++++ Y PRKG++A+EVLQ +L+S+ + +ILQ+D+A Sbjct: 420 VKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQA 479 Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540 LT EK Q K EA + E + L Q++ +QMM+ +ER QE + Q ME ++N Sbjct: 480 LTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQN 535 Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSV 592 ++ E +KM +M+ L+ F+ SL E+ + + N++P V Sbjct: 536 WLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV---NNDDPCV 584 >gi|16418425 guanylate-binding protein 5 [Homo sapiens] Length = 586 Score = 593 bits (1529), Expect = e-169 Identities = 307/592 (51%), Positives = 415/592 (70%), Gaps = 8/592 (1%) Query: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 MA EIHM P+CL EN L VN EALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG Sbjct: 1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60 Query: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120 KNKGF + TV+S TKGIW+WCVPHP+ PNHTL+LLDTEGLGD+EK+D K+D IFALA+ Sbjct: 61 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120 Query: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180 LLSS+FVYN++ I+ A++ LH VTELT+L++A++ P D VED ++ SFFPD +WT+ Sbjct: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180 Query: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240 RDF L L++DG +T DEYLEN+L+ G + ++QN N PR I+ FFPK+KCF+FD P Sbjct: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240 Query: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300 + KK L +E + +D+L+ F Q FCSYIF+H+ TKTL GI+V G+RL LV TY+ Sbjct: 241 HQKK-LAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYV 299 Query: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360 +AI+SG PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ P +TLQELLD+H E Sbjct: 300 NAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSE 359 Query: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420 REAI VFM+ SFKD Q FQK+L ++ K+ D +N EAS+ YC A LK + L E+ Sbjct: 360 REAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEA 419 Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480 + +G + PGGHN++++ ++++ Y PRKG++A+EVLQ +L+S+ + +ILQ+D+A Sbjct: 420 VKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQA 479 Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540 LT EK Q K EA + E + L Q++ +QMM+ +ER QE + Q ME ++N Sbjct: 480 LTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQN 535 Query: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSV 592 ++ E +KM +M+ L+ F+ SL E+ + + N++P V Sbjct: 536 WLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV---NNDDPCV 584 >gi|169160863 PREDICTED: similar to guanylate-binding protein 5 [Homo sapiens] Length = 112 Score = 102 bits (253), Expect = 1e-21 Identities = 51/67 (76%), Positives = 60/67 (89%), Gaps = 1/67 (1%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQ 377 LAQ ENS A+QRAANHYSQQMAQ++RFPTD LQELLD+H CEREAIAVFME+S + ++Q Sbjct: 3 LAQRENSVALQRAANHYSQQMAQRMRFPTDMLQELLDMHTACEREAIAVFMEHS-RGENQ 61 Query: 378 EFQKKLV 384 EFQKKL+ Sbjct: 62 EFQKKLM 68 >gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens] Length = 583 Score = 72.8 bits (177), Expect = 9e-13 Identities = 89/395 (22%), Positives = 163/395 (41%), Gaps = 45/395 (11%) Query: 38 VVVVAIVGLYRTGKSYLM--------NK-----LAGKNK---GFPLGCTVKSETKGIWMW 81 +VVV++ G +R GKS+L+ NK + G N+ GF + ET GI +W Sbjct: 94 IVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVW 153 Query: 82 ----CVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137 + P+ ++L+DT+G D + S K + +FAL+ + SS VYN I Sbjct: 154 NEVFVIDRPNGTKVAVLLMDTQGAFDSQ-STIKDCATVFALSTMTSSVQVYNLSQNIQED 212 Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197 L+ L TE L + +P F ++ +RD++ + Sbjct: 213 DLQHLQLFTEYGRLAMEEIYQKP------------FQTLMFLIRDWSYPYEHSYGLEGGK 260 Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQL 257 ++LE L++ ++ ++QN R+ I + F CF+ P K + R + Sbjct: 261 QFLEKRLQVKQNQHEELQN---VRKHIHNCFSNLGCFLLPHP-GLKVATNPSFDGRLKDI 316 Query: 258 DSNFQMQSENFCSYIFTHAK-TKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMA 316 D +F+ + N + + G VT L + Y+ P ++ + Sbjct: 317 DEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQ 376 Query: 317 VLAQCENSAAVQRAANHYSQQMAQ------QVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 A+ N AAV A + Y + M Q P+D ++ LD+ V ++ +V + Sbjct: 377 ATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-KKM 435 Query: 371 SFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKY 405 + + +Q +L +E+ +F+ N+ + Y Sbjct: 436 GGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFY 470 >gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens] Length = 579 Score = 72.8 bits (177), Expect = 9e-13 Identities = 89/395 (22%), Positives = 163/395 (41%), Gaps = 45/395 (11%) Query: 38 VVVVAIVGLYRTGKSYLM--------NK-----LAGKNK---GFPLGCTVKSETKGIWMW 81 +VVV++ G +R GKS+L+ NK + G N+ GF + ET GI +W Sbjct: 94 IVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVW 153 Query: 82 ----CVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137 + P+ ++L+DT+G D + S K + +FAL+ + SS VYN I Sbjct: 154 NEVFVIDRPNGTKVAVLLMDTQGAFDSQ-STIKDCATVFALSTMTSSVQVYNLSQNIQED 212 Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197 L+ L TE L + +P F ++ +RD++ + Sbjct: 213 DLQHLQLFTEYGRLAMEEIYQKP------------FQTLMFLIRDWSYPYEHSYGLEGGK 260 Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQL 257 ++LE L++ ++ ++QN R+ I + F CF+ P K + R + Sbjct: 261 QFLEKRLQVKQNQHEELQN---VRKHIHNCFSNLGCFLLPHP-GLKVATNPSFDGRLKDI 316 Query: 258 DSNFQMQSENFCSYIFTHAK-TKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMA 316 D +F+ + N + + G VT L + Y+ P ++ + Sbjct: 317 DEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQ 376 Query: 317 VLAQCENSAAVQRAANHYSQQMAQ------QVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 A+ N AAV A + Y + M Q P+D ++ LD+ V ++ +V + Sbjct: 377 ATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-KKM 435 Query: 371 SFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKY 405 + + +Q +L +E+ +F+ N+ + Y Sbjct: 436 GGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFY 470 >gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens] Length = 553 Score = 71.2 bits (173), Expect = 3e-12 Identities = 83/385 (21%), Positives = 162/385 (42%), Gaps = 45/385 (11%) Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFPLGCTVKSETKGIWMW 81 VV V++ G +R GKS+LM+ + N+ GF + ET GI +W Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126 Query: 82 C----VPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137 + P ++L+DT+G D + S + + +FAL+ ++SS VYN + Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFDSQ-STLRDSATVFALSTMISSIQVYNLSQNVQED 185 Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197 L+ L TE L ++ +P F I+ VRD++ + Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233 Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVE-EVREDQ 256 ++LE LK+ ++ ++QN R+ I F CF+ P K+ + + + + Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHP--GLKVATNPNFDGKLKE 288 Query: 257 LDSNFQMQSENFCSYIFTHAKTKTLRE--GILVTGNRLGMLVETYLDAINSGATPCLENA 314 +D F + ++ + ++ ++E G +T L + Y+ P ++ Sbjct: 289 IDDEFIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSM 347 Query: 315 MAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL--QELLDVHAVCEREAIAVFMEYSF 372 + A+ N AAV A + Y+++M + L +L H + E++ +F Sbjct: 348 LQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVK- 406 Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQ 397 K +EF ++ + +E + ++ +Q Sbjct: 407 KMGGEEFSRRYLQQLESEIDELYIQ 431 >gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens] Length = 553 Score = 71.2 bits (173), Expect = 3e-12 Identities = 83/385 (21%), Positives = 162/385 (42%), Gaps = 45/385 (11%) Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFPLGCTVKSETKGIWMW 81 VV V++ G +R GKS+LM+ + N+ GF + ET GI +W Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126 Query: 82 C----VPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137 + P ++L+DT+G D + S + + +FAL+ ++SS VYN + Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFDSQ-STLRDSATVFALSTMISSIQVYNLSQNVQED 185 Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197 L+ L TE L ++ +P F I+ VRD++ + Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233 Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVE-EVREDQ 256 ++LE LK+ ++ ++QN R+ I F CF+ P K+ + + + + Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHP--GLKVATNPNFDGKLKE 288 Query: 257 LDSNFQMQSENFCSYIFTHAKTKTLRE--GILVTGNRLGMLVETYLDAINSGATPCLENA 314 +D F + ++ + ++ ++E G +T L + Y+ P ++ Sbjct: 289 IDDEFIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSM 347 Query: 315 MAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL--QELLDVHAVCEREAIAVFMEYSF 372 + A+ N AAV A + Y+++M + L +L H + E++ +F Sbjct: 348 LQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVK- 406 Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQ 397 K +EF ++ + +E + ++ +Q Sbjct: 407 KMGGEEFSRRYLQQLESEIDELYIQ 431 >gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens] Length = 558 Score = 71.2 bits (173), Expect = 3e-12 Identities = 83/385 (21%), Positives = 162/385 (42%), Gaps = 45/385 (11%) Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFPLGCTVKSETKGIWMW 81 VV V++ G +R GKS+LM+ + N+ GF + ET GI +W Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126 Query: 82 C----VPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQ 137 + P ++L+DT+G D + S + + +FAL+ ++SS VYN + Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFDSQ-STLRDSATVFALSTMISSIQVYNLSQNVQED 185 Query: 138 ALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197 L+ L TE L ++ +P F I+ VRD++ + Sbjct: 186 DLQHLQLFTEYGRLAMEETFLKP------------FQSLIFLVRDWSFPYEFSYGADGGA 233 Query: 198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVE-EVREDQ 256 ++LE LK+ ++ ++QN R+ I F CF+ P K+ + + + + Sbjct: 234 KFLEKRLKVSGNQHEELQN---VRKHIHSCFTNISCFLLPHP--GLKVATNPNFDGKLKE 288 Query: 257 LDSNFQMQSENFCSYIFTHAKTKTLRE--GILVTGNRLGMLVETYLDAINSGATPCLENA 314 +D F + ++ + ++ ++E G +T L + Y+ P ++ Sbjct: 289 IDDEFIKNLKILIPWLLS-PESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSM 347 Query: 315 MAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL--QELLDVHAVCEREAIAVFMEYSF 372 + A+ N AAV A + Y+++M + L +L H + E++ +F Sbjct: 348 LQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVK- 406 Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQ 397 K +EF ++ + +E + ++ +Q Sbjct: 407 KMGGEEFSRRYLQQLESEIDELYIQ 431 >gi|45827806 atlastin 3 [Homo sapiens] Length = 541 Score = 66.6 bits (161), Expect = 7e-11 Identities = 99/432 (22%), Positives = 165/432 (38%), Gaps = 52/432 (12%) Query: 2 ASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQP------VVVVAIVGLYRTGKSYLM 55 A E PGPV + K + + S + Q VVVV++ G +R GKS+++ Sbjct: 18 AMESSKPGPVQVVLVQKDQHSFELDEKALASILLQDHIRDLDVVVVSVAGAFRKGKSFIL 77 Query: 56 N---------KLAGKNK----------GFPLGCTVKSETKGIWMWC----VPHPSKPNHT 92 + K +G + GF ET GI +W V P Sbjct: 78 DFMLRYLYSQKESGHSNWLGDPEEPLTGFSWRGGSDPETTGIQIWSEVFTVEKPGGKKVA 137 Query: 93 LILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQALEQLHYVTELTELI 152 ++L+DT+G D + S K + IFAL+ + SS +YN I L+QL TE L Sbjct: 138 VVLMDTQGAFDSQ-STVKDCATIFALSTMTSSVQIYNLSQNIQEDDLQQLQLFTEYGRLA 196 Query: 153 RAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITEDEYLENALKLISGKNP 212 DE+ F F ++ VRD++ + +L+ L++ ++ Sbjct: 197 M-------DEI-----FQKPFQTLMFLVRDWSFPYEYSYGLQGGMAFLDKRLQVKEHQHE 244 Query: 213 QIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYI 272 +IQN R I F CF+ P + +D + F+ Q + Y+ Sbjct: 245 EIQN---VRNHIHSCFSDVTCFLLPHPGLQVATSPDFDGKLKD-IAGEFKEQLQALIPYV 300 Query: 273 FTHAKTKTLR-EGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAA 331 +K G VT L + Y+ P ++ + A+ N AA A Sbjct: 301 LNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSMLQATAEANNLAAAASAK 360 Query: 332 NHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAV-----FMEYSFKDKSQEFQKKLVDT 386 + Y M + L + CE + +A+ + KD S +Q++L + Sbjct: 361 DIYYNNMEEVCGGEKPYLSPDILEEKHCEFKQLALDHFKKTKKMGGKDFSFRYQQELEEE 420 Query: 387 MEKKKEDFVLQN 398 +++ E+F N Sbjct: 421 IKELYENFCKHN 432 >gi|58530840 desmoplakin isoform I [Homo sapiens] Length = 2871 Score = 53.5 bits (127), Expect = 6e-07 Identities = 82/432 (18%), Positives = 181/432 (41%), Gaps = 80/432 (18%) Query: 200 LENALKLISGKNPQIQN------SNKPREW--------IRHFFPKQKCFV---FDRPIND 242 LE A K I KN +I+ R W +R+ + ++ + F+ IN Sbjct: 1313 LEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINI 1372 Query: 243 KKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDA 302 K +H +++++ S ++ Q +N + ++L E I N L E Sbjct: 1373 TKTTIHQLTMQKEEDTSGYRAQIDNLTR------ENRSLSEEIKRLKNTLTQTTEN---- 1422 Query: 303 INSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCERE 362 L + E Q+A Q QQ+ + ++ +V ++ Sbjct: 1423 ---------------LRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQ 1467 Query: 363 AIAVFMEYSFKDKSQEFQ--KKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420 ++ + + +DK++E + K+L+D ++ L++E A + Q +L++ + TE+ Sbjct: 1468 SLDDAAK-TIQDKNKEIERLKQLIDKETNDRK--CLEDENARLQRVQYDLQKANSSATET 1524 Query: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480 I++ + + ++ DY V ++ D+ + F S ++ + ++ Sbjct: 1525 INK--------LKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEE 1576 Query: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQ--------QQMMEAQ--ERSFQENIAQL 530 L ++ + K++ E+E E +R+ KEQ QQ+ +A ++ ++++ Q Sbjct: 1577 LNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQ 1636 Query: 531 KKKME---RERENYMRELRKMLSH----KMKVLEE--------LLTEGFKEIFESLNEEI 575 + ++ RE++ ELR++ S + ++L+E L E F++ E + + Sbjct: 1637 RDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSL 1696 Query: 576 NRLKEQIEAAEN 587 N K +IE ++ Sbjct: 1697 NESKIEIERLQS 1708 Score = 35.8 bits (81), Expect = 0.12 Identities = 54/220 (24%), Positives = 88/220 (40%), Gaps = 32/220 (14%) Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGH 432 +DKS+E QK + + +D+ LQ A Y L LL I R P G Sbjct: 941 RDKSEEVQK-IAELCANSIKDYELQ----LASYTSG----LETLLNIPIKRTMIQSPSG- 990 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQ 492 + L+ + Y + + L L+S +E+ L++ K E+ A+ Sbjct: 991 -VILQEAADVHARYIELLTRSGDYYRFLSEMLKS---LEDLKLKNTKIEVLEEELRLARD 1046 Query: 493 AKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHK 552 A E K + L + QK +Q +Q K K+ + EL++ Sbjct: 1047 ANSENCNKNKFLDQNLQK------------YQAECSQFKAKLAS-----LEELKRQAELD 1089 Query: 553 MKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSV 592 K ++ L + + +I E LNE+I RL +IE + SV Sbjct: 1090 GKSAKQNLDKCYGQIKE-LNEKITRLTYEIEDEKRRRKSV 1128 Score = 34.7 bits (78), Expect = 0.28 Identities = 48/230 (20%), Positives = 103/230 (44%), Gaps = 36/230 (15%) Query: 375 KSQEFQKKLVDTMEKKKEDFVL--QNEEASAKYCQAELKRLSELLTESISRGTFFVPGGH 432 K Q + +L M+++ ED Q+ E +AK Q + K + L E Sbjct: 1287 KKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAE------------- 1333 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQ-------SQVVIEESILQSDKALTAGE 485 EAK++ E + L + +E++ Q ++ I + +Q ++ T+G Sbjct: 1334 -FQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEED-TSGY 1391 Query: 486 KA-----IAAKQAKKEAAEKEQELLRQKQKEQQQMME--AQERSFQENIAQLKKKMERER 538 +A ++ E ++ + L Q + +++ E Q+++ ++Q K+++E E Sbjct: 1392 RAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVE- 1450 Query: 539 ENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588 +R++ +M + + ++ L + K I + N+EI RLK+ I+ N+ Sbjct: 1451 ---LRQVTQMRTEESVRYKQSLDDAAKTI-QDKNKEIERLKQLIDKETND 1496 Score = 33.9 bits (76), Expect = 0.47 Identities = 53/269 (19%), Positives = 113/269 (42%), Gaps = 39/269 (14%) Query: 350 QELLDVHAVCEREAIAVFMEYSF--KDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQ 407 + L H + E E + +EY + +S+ K +E + + + N + Sbjct: 1711 ENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLI 1770 Query: 408 AELKRLSELLTESISRGTFFVPGGHNIYLEAKKKI-----EQDYTLVPRKGVKADEVLQS 462 +L+R E L + I + N E+K + E++ LV K ++ D+ Sbjct: 1771 NDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ 1830 Query: 463 FLQSQVVIEESILQSD----KALTAGEKAIA-------AKQAKKEAA-----------EK 500 L+ ++ +S L+++ + L ++ I + ++KE A E+ Sbjct: 1831 RLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1890 Query: 501 EQELLRQK----QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML-----SH 551 E+ LR + Q E +++ E R +++ + + ++E ER Y RE+ K+ SH Sbjct: 1891 EKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSH 1950 Query: 552 KMKVLE-ELLTEGFKEIFESLNEEINRLK 579 + E E + K +F+ L +++ ++ Sbjct: 1951 RETQTECEWTVDTSKLVFDGLRKKVTAMQ 1979 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 53.5 bits (127), Expect = 6e-07 Identities = 53/243 (21%), Positives = 101/243 (41%), Gaps = 28/243 (11%) Query: 377 QEFQKKLVDTMEKKKEDFVLQNE-EASAKYCQAELKRLSELLT-------------ESIS 422 ++FQ++L D + E F E E AK +A+L +L E L E ++ Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714 Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482 G N + K+++E + + + +++ + Q L Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774 Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERS----FQENIAQLKKKMERER 538 ++ ++ E++ + LR K E + ++++ +S + IAQL++++E+E Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834 Query: 539 ENYMRELRKMLSHKMKVLEELL---------TEGFKEIFESLNEEINRLKEQIEAAENEE 589 + K L K K L+E+L E +KE E N + +LK Q+E AE E Sbjct: 1835 RE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893 Query: 590 PSV 592 + Sbjct: 1894 QRI 1896 Score = 38.9 bits (89), Expect = 0.015 Identities = 36/165 (21%), Positives = 82/165 (49%), Gaps = 9/165 (5%) Query: 440 KKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAE 499 K++EQ ++ + + E LQ+ + EE ++ E+ + +A+ E E Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935 Query: 500 -KEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMER-ERENYMRELRKML------SH 551 + Q+L +++K QQM++ +E+ +E A+ K ++E+ E +++L + ++ Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995 Query: 552 KMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596 K+ +LL E ++ +L EE + K + +N+ S+ S++ Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAK-NLTKLKNKHESMISEL 1039 Score = 37.0 bits (84), Expect = 0.056 Identities = 67/299 (22%), Positives = 120/299 (40%), Gaps = 54/299 (18%) Query: 328 QRAANHYSQ--QMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVD 385 Q+A N + Q Q+ + LQE L A E A A M K QE ++ ++ Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQ--AETELYAEAEEMRVRLAAKKQELEE-ILH 925 Query: 386 TMEKKKEDFVLQNEEASAKYCQAELKRLSE--------LLTESISRGTFFVPGGHNIYLE 437 ME + L+ EE + QAE K++++ L E +R + + E Sbjct: 926 EMEAR-----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL---EKVTAE 977 Query: 438 AK-KKIEQDYTLVPRKGVKA-------DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 AK KK+E + ++ + K +E + + EE K E I+ Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037 Query: 490 AKQA---KKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE------- 539 + K+E + +E E L++K + Q Q IA+LK ++ ++ E Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097 Query: 540 ----------NYMRELRKMLSHKMKVLEELLTE-----GFKEIFESLNEEINRLKEQIE 583 N ++++R++ H + E+L +E ++ L EE+ LK ++E Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156 Score = 36.2 bits (82), Expect = 0.095 Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 18/140 (12%) Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQ 519 L+ L S +E + ++ +T +KA+ + EA +E +RQK + + + Q Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE---MRQKHAQAVEELTEQ 1211 Query: 520 ERSFQE---NIAQLKKKMERERENYMRELRKM------LSHKMKVLEELLTEGFKEIFE- 569 F+ N+ + K+ +E+E + ELR + + HK K LE + E + + Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271 Query: 570 -----SLNEEINRLKEQIEA 584 LN+++++L+ ++E+ Sbjct: 1272 ERARAELNDKVHKLQNEVES 1291 Score = 35.8 bits (81), Expect = 0.12 Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 22/176 (12%) Query: 380 QKKLVDTMEKKKEDF---VLQNEEASAKYC----QAELK-RLSELLTESISRGTFFVPGG 431 Q++LV +EKK+ F + + + S+KY +AE + R E S++R Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL------ 1492 Query: 432 HNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 LEAK+++E+ K +KA+ ++ + S+ + +++ + +K+ A E + Sbjct: 1493 -EEALEAKEELERT-----NKMLKAE--MEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544 Query: 492 QAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547 + + E E E + + + M+A + F+ ++ ++ E +R R+L + Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600 Score = 33.5 bits (75), Expect = 0.62 Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 49/288 (17%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 ++C + + N ++ +V T L E E +AI + + + Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNE-------AEGKAIKLAKDVA------S 1312 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKR--LSELLTESISRGTFFVPGGHNIYL 436 +L DT E +E+ Q S K Q E +R L + L E + Sbjct: 1313 LSSQLQDTQELLQEE-TRQKLNVSTKLRQLEEERNSLQDQLDEE---------------M 1356 Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496 EAK+ +E+ + + + + + LQ F + +EE + K + + K A + Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416 Query: 497 AAEKEQELLRQK----------QKEQQQMMEAQERSFQENIAQ---LKKKMERERENYMR 543 EK + L+Q+ Q++ +E ++R F + +A+ + K ER+ Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476 Query: 544 ELRKMLSHKM---KVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588 E R+ + + + LEE L KE E N+ + E + +++++ Sbjct: 1477 EAREKETKALSLARALEEALEA--KEELERTNKMLKAEMEDLVSSKDD 1522 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 53.5 bits (127), Expect = 6e-07 Identities = 53/243 (21%), Positives = 101/243 (41%), Gaps = 28/243 (11%) Query: 377 QEFQKKLVDTMEKKKEDFVLQNE-EASAKYCQAELKRLSELLT-------------ESIS 422 ++FQ++L D + E F E E AK +A+L +L E L E ++ Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721 Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482 G N + K+++E + + + +++ + Q L Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781 Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERS----FQENIAQLKKKMERER 538 ++ ++ E++ + LR K E + ++++ +S + IAQL++++E+E Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841 Query: 539 ENYMRELRKMLSHKMKVLEELL---------TEGFKEIFESLNEEINRLKEQIEAAENEE 589 + K L K K L+E+L E +KE E N + +LK Q+E AE E Sbjct: 1842 RE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900 Query: 590 PSV 592 + Sbjct: 1901 QRI 1903 Score = 38.9 bits (89), Expect = 0.015 Identities = 36/165 (21%), Positives = 82/165 (49%), Gaps = 9/165 (5%) Query: 440 KKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAE 499 K++EQ ++ + + E LQ+ + EE ++ E+ + +A+ E E Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942 Query: 500 -KEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMER-ERENYMRELRKML------SH 551 + Q+L +++K QQM++ +E+ +E A+ K ++E+ E +++L + ++ Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002 Query: 552 KMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596 K+ +LL E ++ +L EE + K + +N+ S+ S++ Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAK-NLTKLKNKHESMISEL 1046 Score = 37.0 bits (84), Expect = 0.056 Identities = 67/299 (22%), Positives = 120/299 (40%), Gaps = 54/299 (18%) Query: 328 QRAANHYSQ--QMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVD 385 Q+A N + Q Q+ + LQE L A E A A M K QE ++ ++ Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQ--AETELYAEAEEMRVRLAAKKQELEE-ILH 932 Query: 386 TMEKKKEDFVLQNEEASAKYCQAELKRLSE--------LLTESISRGTFFVPGGHNIYLE 437 ME + L+ EE + QAE K++++ L E +R + + E Sbjct: 933 EMEAR-----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL---EKVTAE 984 Query: 438 AK-KKIEQDYTLVPRKGVKA-------DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 AK KK+E + ++ + K +E + + EE K E I+ Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044 Query: 490 AKQA---KKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE------- 539 + K+E + +E E L++K + Q Q IA+LK ++ ++ E Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104 Query: 540 ----------NYMRELRKMLSHKMKVLEELLTE-----GFKEIFESLNEEINRLKEQIE 583 N ++++R++ H + E+L +E ++ L EE+ LK ++E Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163 Score = 36.2 bits (82), Expect = 0.095 Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 18/140 (12%) Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQ 519 L+ L S +E + ++ +T +KA+ + EA +E +RQK + + + Q Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE---MRQKHAQAVEELTEQ 1218 Query: 520 ERSFQE---NIAQLKKKMERERENYMRELRKM------LSHKMKVLEELLTEGFKEIFE- 569 F+ N+ + K+ +E+E + ELR + + HK K LE + E + + Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278 Query: 570 -----SLNEEINRLKEQIEA 584 LN+++++L+ ++E+ Sbjct: 1279 ERARAELNDKVHKLQNEVES 1298 Score = 35.8 bits (81), Expect = 0.12 Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 22/176 (12%) Query: 380 QKKLVDTMEKKKEDF---VLQNEEASAKYC----QAELK-RLSELLTESISRGTFFVPGG 431 Q++LV +EKK+ F + + + S+KY +AE + R E S++R Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL------ 1499 Query: 432 HNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 LEAK+++E+ K +KA+ ++ + S+ + +++ + +K+ A E + Sbjct: 1500 -EEALEAKEELERT-----NKMLKAE--MEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551 Query: 492 QAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547 + + E E E + + + M+A + F+ ++ ++ E +R R+L + Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607 Score = 33.5 bits (75), Expect = 0.62 Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 49/288 (17%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 ++C + + N ++ +V T L E E +AI + + + Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNE-------AEGKAIKLAKDVA------S 1319 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKR--LSELLTESISRGTFFVPGGHNIYL 436 +L DT E +E+ Q S K Q E +R L + L E + Sbjct: 1320 LSSQLQDTQELLQEE-TRQKLNVSTKLRQLEEERNSLQDQLDEE---------------M 1363 Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496 EAK+ +E+ + + + + + LQ F + +EE + K + + K A + Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423 Query: 497 AAEKEQELLRQK----------QKEQQQMMEAQERSFQENIAQ---LKKKMERERENYMR 543 EK + L+Q+ Q++ +E ++R F + +A+ + K ER+ Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483 Query: 544 ELRKMLSHKM---KVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588 E R+ + + + LEE L KE E N+ + E + +++++ Sbjct: 1484 EAREKETKALSLARALEEALEA--KEELERTNKMLKAEMEDLVSSKDD 1529 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 53.5 bits (127), Expect = 6e-07 Identities = 53/243 (21%), Positives = 101/243 (41%), Gaps = 28/243 (11%) Query: 377 QEFQKKLVDTMEKKKEDFVLQNE-EASAKYCQAELKRLSELLT-------------ESIS 422 ++FQ++L D + E F E E AK +A+L +L E L E ++ Sbjct: 1662 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1721 Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482 G N + K+++E + + + +++ + Q L Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781 Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERS----FQENIAQLKKKMERER 538 ++ ++ E++ + LR K E + ++++ +S + IAQL++++E+E Sbjct: 1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1841 Query: 539 ENYMRELRKMLSHKMKVLEELL---------TEGFKEIFESLNEEINRLKEQIEAAENEE 589 + K L K K L+E+L E +KE E N + +LK Q+E AE E Sbjct: 1842 RE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900 Query: 590 PSV 592 + Sbjct: 1901 QRI 1903 Score = 38.9 bits (89), Expect = 0.015 Identities = 36/165 (21%), Positives = 82/165 (49%), Gaps = 9/165 (5%) Query: 440 KKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAE 499 K++EQ ++ + + E LQ+ + EE ++ E+ + +A+ E E Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942 Query: 500 -KEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMER-ERENYMRELRKML------SH 551 + Q+L +++K QQM++ +E+ +E A+ K ++E+ E +++L + ++ Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002 Query: 552 KMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596 K+ +LL E ++ +L EE + K + +N+ S+ S++ Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAK-NLTKLKNKHESMISEL 1046 Score = 37.0 bits (84), Expect = 0.056 Identities = 67/299 (22%), Positives = 120/299 (40%), Gaps = 54/299 (18%) Query: 328 QRAANHYSQ--QMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVD 385 Q+A N + Q Q+ + LQE L A E A A M K QE ++ ++ Sbjct: 876 QKAENELKELEQKHSQLTEEKNLLQEQLQ--AETELYAEAEEMRVRLAAKKQELEE-ILH 932 Query: 386 TMEKKKEDFVLQNEEASAKYCQAELKRLSE--------LLTESISRGTFFVPGGHNIYLE 437 ME + L+ EE + QAE K++++ L E +R + + E Sbjct: 933 EMEAR-----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL---EKVTAE 984 Query: 438 AK-KKIEQDYTLVPRKGVKA-------DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 AK KK+E + ++ + K +E + + EE K E I+ Sbjct: 985 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1044 Query: 490 AKQA---KKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE------- 539 + K+E + +E E L++K + Q Q IA+LK ++ ++ E Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1104 Query: 540 ----------NYMRELRKMLSHKMKVLEELLTE-----GFKEIFESLNEEINRLKEQIE 583 N ++++R++ H + E+L +E ++ L EE+ LK ++E Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163 Score = 36.2 bits (82), Expect = 0.095 Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 18/140 (12%) Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQ 519 L+ L S +E + ++ +T +KA+ + EA +E +RQK + + + Q Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE---MRQKHAQAVEELTEQ 1218 Query: 520 ERSFQE---NIAQLKKKMERERENYMRELRKM------LSHKMKVLEELLTEGFKEIFE- 569 F+ N+ + K+ +E+E + ELR + + HK K LE + E + + Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278 Query: 570 -----SLNEEINRLKEQIEA 584 LN+++++L+ ++E+ Sbjct: 1279 ERARAELNDKVHKLQNEVES 1298 Score = 35.8 bits (81), Expect = 0.12 Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 22/176 (12%) Query: 380 QKKLVDTMEKKKEDF---VLQNEEASAKYC----QAELK-RLSELLTESISRGTFFVPGG 431 Q++LV +EKK+ F + + + S+KY +AE + R E S++R Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL------ 1499 Query: 432 HNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 LEAK+++E+ K +KA+ ++ + S+ + +++ + +K+ A E + Sbjct: 1500 -EEALEAKEELERT-----NKMLKAE--MEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1551 Query: 492 QAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547 + + E E E + + + M+A + F+ ++ ++ E +R R+L + Sbjct: 1552 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1607 Score = 33.5 bits (75), Expect = 0.62 Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 49/288 (17%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 ++C + + N ++ +V T L E E +AI + + + Sbjct: 1273 SKCSDGERARAELNDKVHKLQNEVESVTGMLNE-------AEGKAIKLAKDVA------S 1319 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKR--LSELLTESISRGTFFVPGGHNIYL 436 +L DT E +E+ Q S K Q E +R L + L E + Sbjct: 1320 LSSQLQDTQELLQEE-TRQKLNVSTKLRQLEEERNSLQDQLDEE---------------M 1363 Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496 EAK+ +E+ + + + + + LQ F + +EE + K + + K A + Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423 Query: 497 AAEKEQELLRQK----------QKEQQQMMEAQERSFQENIAQ---LKKKMERERENYMR 543 EK + L+Q+ Q++ +E ++R F + +A+ + K ER+ Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483 Query: 544 ELRKMLSHKM---KVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588 E R+ + + + LEE L KE E N+ + E + +++++ Sbjct: 1484 EAREKETKALSLARALEEALEA--KEELERTNKMLKAEMEDLVSSKDD 1529 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 53.5 bits (127), Expect = 6e-07 Identities = 53/243 (21%), Positives = 101/243 (41%), Gaps = 28/243 (11%) Query: 377 QEFQKKLVDTMEKKKEDFVLQNE-EASAKYCQAELKRLSELLT-------------ESIS 422 ++FQ++L D + E F E E AK +A+L +L E L E ++ Sbjct: 1655 KDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELA 1714 Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482 G N + K+++E + + + +++ + Q L Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1774 Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERS----FQENIAQLKKKMERER 538 ++ ++ E++ + LR K E + ++++ +S + IAQL++++E+E Sbjct: 1775 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEA 1834 Query: 539 ENYMRELRKMLSHKMKVLEELL---------TEGFKEIFESLNEEINRLKEQIEAAENEE 589 + K L K K L+E+L E +KE E N + +LK Q+E AE E Sbjct: 1835 RE-KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893 Query: 590 PSV 592 + Sbjct: 1894 QRI 1896 Score = 38.9 bits (89), Expect = 0.015 Identities = 36/165 (21%), Positives = 82/165 (49%), Gaps = 9/165 (5%) Query: 440 KKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAE 499 K++EQ ++ + + E LQ+ + EE ++ E+ + +A+ E E Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935 Query: 500 -KEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMER-ERENYMRELRKML------SH 551 + Q+L +++K QQM++ +E+ +E A+ K ++E+ E +++L + ++ Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995 Query: 552 KMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596 K+ +LL E ++ +L EE + K + +N+ S+ S++ Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAK-NLTKLKNKHESMISEL 1039 Score = 37.0 bits (84), Expect = 0.056 Identities = 67/299 (22%), Positives = 120/299 (40%), Gaps = 54/299 (18%) Query: 328 QRAANHYSQ--QMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVD 385 Q+A N + Q Q+ + LQE L A E A A M K QE ++ ++ Sbjct: 869 QKAENELKELEQKHSQLTEEKNLLQEQLQ--AETELYAEAEEMRVRLAAKKQELEE-ILH 925 Query: 386 TMEKKKEDFVLQNEEASAKYCQAELKRLSE--------LLTESISRGTFFVPGGHNIYLE 437 ME + L+ EE + QAE K++++ L E +R + + E Sbjct: 926 EMEAR-----LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL---EKVTAE 977 Query: 438 AK-KKIEQDYTLVPRKGVKA-------DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 AK KK+E + ++ + K +E + + EE K E I+ Sbjct: 978 AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMIS 1037 Query: 490 AKQA---KKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE------- 539 + K+E + +E E L++K + Q Q IA+LK ++ ++ E Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALA 1097 Query: 540 ----------NYMRELRKMLSHKMKVLEELLTE-----GFKEIFESLNEEINRLKEQIE 583 N ++++R++ H + E+L +E ++ L EE+ LK ++E Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156 Score = 36.2 bits (82), Expect = 0.095 Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 18/140 (12%) Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQ 519 L+ L S +E + ++ +T +KA+ + EA +E +RQK + + + Q Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE---MRQKHAQAVEELTEQ 1211 Query: 520 ERSFQE---NIAQLKKKMERERENYMRELRKM------LSHKMKVLEELLTEGFKEIFE- 569 F+ N+ + K+ +E+E + ELR + + HK K LE + E + + Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271 Query: 570 -----SLNEEINRLKEQIEA 584 LN+++++L+ ++E+ Sbjct: 1272 ERARAELNDKVHKLQNEVES 1291 Score = 35.8 bits (81), Expect = 0.12 Identities = 38/176 (21%), Positives = 83/176 (47%), Gaps = 22/176 (12%) Query: 380 QKKLVDTMEKKKEDF---VLQNEEASAKYC----QAELK-RLSELLTESISRGTFFVPGG 431 Q++LV +EKK+ F + + + S+KY +AE + R E S++R Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARAL------ 1492 Query: 432 HNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 LEAK+++E+ K +KA+ ++ + S+ + +++ + +K+ A E + Sbjct: 1493 -EEALEAKEELERT-----NKMLKAE--MEDLVSSKDDVGKNVHELEKSKRALETQMEEM 1544 Query: 492 QAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547 + + E E E + + + M+A + F+ ++ ++ E +R R+L + Sbjct: 1545 KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE 1600 Score = 33.5 bits (75), Expect = 0.62 Identities = 58/288 (20%), Positives = 114/288 (39%), Gaps = 49/288 (17%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 ++C + + N ++ +V T L E E +AI + + + Sbjct: 1266 SKCSDGERARAELNDKVHKLQNEVESVTGMLNE-------AEGKAIKLAKDVA------S 1312 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKR--LSELLTESISRGTFFVPGGHNIYL 436 +L DT E +E+ Q S K Q E +R L + L E + Sbjct: 1313 LSSQLQDTQELLQEE-TRQKLNVSTKLRQLEEERNSLQDQLDEE---------------M 1356 Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496 EAK+ +E+ + + + + + LQ F + +EE + K + + K A + Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416 Query: 497 AAEKEQELLRQK----------QKEQQQMMEAQERSFQENIAQ---LKKKMERERENYMR 543 EK + L+Q+ Q++ +E ++R F + +A+ + K ER+ Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476 Query: 544 ELRKMLSHKM---KVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588 E R+ + + + LEE L KE E N+ + E + +++++ Sbjct: 1477 EAREKETKALSLARALEEALEA--KEELERTNKMLKAEMEDLVSSKDD 1522 >gi|71061468 centromere protein E [Homo sapiens] Length = 2701 Score = 52.8 bits (125), Expect = 1e-06 Identities = 48/223 (21%), Positives = 106/223 (47%), Gaps = 21/223 (9%) Query: 368 MEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFF 427 +E + K + + ++ L +T K D +Q E +A+ E K + L E IS T Sbjct: 1897 VEETLKLERDQLKESLQET---KARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953 Query: 428 VPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKA 487 + ++K ++++ + +K ++ V + S I E + +K Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINE--------MEQLKKQ 2005 Query: 488 IAAKQAKKEAAEKEQELLRQKQKEQQQMME--AQERSFQENIAQLKKKMERERENYMREL 545 A+ ++ + L +K E + + A+ER + + ++K+ ++ ER+ ++ L Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKER---DELRRIKESLKMERDQFIATL 2062 Query: 546 RKMLS-----HKMKVLEELLTEGFKEIFESLNEEINRLKEQIE 583 R+M++ H++K + LL++G + + ESL E+ +R+KE ++ Sbjct: 2063 REMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK 2105 Score = 38.1 bits (87), Expect = 0.025 Identities = 60/307 (19%), Positives = 122/307 (39%), Gaps = 33/307 (10%) Query: 290 NRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL 349 N L ++E+ + T EN + EN ++ + +Q + + Sbjct: 1053 NELQQMLESVIAEKEQLKTDLKENIEMTI---ENQEELRLLGDELKKQQEIVAQEKNHAI 1109 Query: 350 QELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAE 409 ++ ++ C+R A +E K+KSQ+ Q+K + ++E +Q + + + E Sbjct: 1110 KKEGELSRTCDRLAE---VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNE 1166 Query: 410 LKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVV 469 LK EL E + LE +K+ ++Y V K + + + LQ Sbjct: 1167 LKN-KELTLEHMETER----------LELAQKLNENYEEV--KSITKERKVLKELQKSFE 1213 Query: 470 IEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQ 529 E L+ I +A ++E ++ KE Q+ ++ RS E AQ Sbjct: 1214 TERDHLRG---------YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQ 1264 Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEE 589 + + E+ + + + H+ E+ L KE+ E+ E +N L+ E + ++ Sbjct: 1265 IINTQDLEKSHTKLQEEIPVLHE----EQELLPNVKEVSET-QETMNELELLTEQSTTKD 1319 Query: 590 PSVFSQI 596 + ++I Sbjct: 1320 STTLARI 1326 Score = 33.1 bits (74), Expect = 0.80 Identities = 65/353 (18%), Positives = 138/353 (39%), Gaps = 35/353 (9%) Query: 251 EVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPC 310 E+ +L+ FQ E S KT++E + V ++L + L I + Sbjct: 1327 EMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSK- 1385 Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTL---QELLDVHAVCEREAIAVF 367 E ++ + + + + + + + +R + L + L + H E +++A Sbjct: 1386 QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD--EMKSVA-- 1441 Query: 368 MEYSFKDKSQEFQKKLVDTMEKKKEDF-------VLQNEEASAKYC-----QAELKRLSE 415 KD Q Q+ L ++ KE+ + EE +C + + L Sbjct: 1442 ---KEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRV 1498 Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESIL 475 L+E + + I + + KI++ Y + +K +Q + +E Sbjct: 1499 NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRK 1558 Query: 476 QSDKALTAGE-KAIAAKQAKKEAAEKEQELLRQKQ--KEQQQMMEAQERSFQEN----IA 528 D AL + E K + +E+ E+ Q ++++K+ K Q+ ++ + +EN +A Sbjct: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618 Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQ 581 ++K+ E+E + KM +E L KE FE+ + ++ + Sbjct: 1619 KMKESQEKEYQFLKMTAVNETQEKMCEIEHL-----KEQFETQKLNLENIETE 1666 Score = 32.3 bits (72), Expect = 1.4 Identities = 51/222 (22%), Positives = 94/222 (42%), Gaps = 31/222 (13%) Query: 375 KSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNI 434 K+QE Q+K + E+ E L+ + + ++R L+TE + Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKL------------- 917 Query: 435 YLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAK 494 ++ +E+ TL K D++ Q LQ + IE L+SD T +Q + Sbjct: 918 ----QQTLEEVKTLTQEK----DDLKQ--LQESLQIERDQLKSDIHDTVNMNIDTQEQLR 967 Query: 495 K--EAAEKEQE---LLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549 E+ ++ QE L+ K E+ E + E + ++KM + E + Sbjct: 968 NALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQ 1027 Query: 550 SHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEA--AENEE 589 + V + + E ++IF SL +E N L++ +E+ AE E+ Sbjct: 1028 TLTADVKDNEIIEQQRKIF-SLIQEKNELQQMLESVIAEKEQ 1068 Score = 32.3 bits (72), Expect = 1.4 Identities = 46/232 (19%), Positives = 102/232 (43%), Gaps = 27/232 (11%) Query: 374 DKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHN 433 DK Q+ + K T+ +D + ++ E L ++L I+ Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK-------EQ 1068 Query: 434 IYLEAKKKIE------QDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKA 487 + + K+ IE ++ L+ + K E++ + E + ++ L E+ Sbjct: 1069 LKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEK 1128 Query: 488 IAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRK 547 + K+ ++ EK+Q+LL Q++M E Q++ I ++ + ++ E +N L Sbjct: 1129 L--KEKSQQLQEKQQQLL----NVQEEMSEMQKK-----INEI-ENLKNELKNKELTLEH 1176 Query: 548 MLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599 M + +++ L + L E ++E+ +S+ +E LKE ++ E E + I ++ Sbjct: 1177 METERLE-LAQKLNENYEEV-KSITKERKVLKELQKSFETERDHLRGYIREI 1226 Score = 32.3 bits (72), Expect = 1.4 Identities = 29/144 (20%), Positives = 68/144 (47%), Gaps = 16/144 (11%) Query: 460 LQSFLQSQVVIEESILQSDKALTAGEKAIAA-KQAKKEAAEKEQEL---------LRQKQ 509 LQ +Q E ++ K + +K ++ +Q KK+ ++ L L QK Sbjct: 1818 LQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877 Query: 510 KEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEEL-----LTEGF 564 E + M++ + ++N+ ++++ ++ ER+ L++ + +++ +EL L++ Sbjct: 1878 HENLEEMKSVMKE-RDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEH 1936 Query: 565 KEIFESLNEEINRLKEQIEAAENE 588 KE + L E+I+ QI + + Sbjct: 1937 KETVDKLREKISEKTIQISDIQKD 1960 Score = 30.0 bits (66), Expect = 6.8 Identities = 28/98 (28%), Positives = 49/98 (50%), Gaps = 21/98 (21%) Query: 499 EKEQELLRQKQKEQQQMMEAQERSFQEN--------IAQLKKKMERERENYMRELRKMLS 550 EKE+ L+ K+K EA ER +++ I+ L K + + E Y ++L LS Sbjct: 520 EKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNL-KNLVKHAEVYNQDLENELS 578 Query: 551 HKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENE 588 K+++L E KE ++I +L+E I++ + E Sbjct: 579 SKVELLRE------KE------DQIKKLQEYIDSQKLE 604 >gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 899 Score = 52.0 bits (123), Expect = 2e-06 Identities = 51/226 (22%), Positives = 104/226 (46%), Gaps = 19/226 (8%) Query: 369 EYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFV 428 E + K+QE +KK D EK +E+ ++ E + + ++ E + E + Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK----- 618 Query: 429 PGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAI 488 + + +K EQ+ + ++ ++ + + Q + + E+ L K + + Sbjct: 619 -----MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673 Query: 489 AAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELR 546 ++ +E EK EQE + +K +EQ++ QE+ +E + ++K RE E MRE Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733 Query: 547 KMLSHKMKVLEELLTEGFKEIF---ESLNEEINRLKEQIEAAENEE 589 + KM+ EE + E +E++ E + E+ ++ EQ E +E Sbjct: 734 E----KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775 Score = 49.7 bits (117), Expect = 8e-06 Identities = 52/221 (23%), Positives = 107/221 (48%), Gaps = 13/221 (5%) Query: 376 SQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGH-NI 434 S E + + E KK++ LQ + A+ ++E++ + L + R F +P N Sbjct: 210 SLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNT 269 Query: 435 YLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAK 494 E + E++ +K K +E + + E + + ++ + EK + ++ + Sbjct: 270 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRL--REQE 327 Query: 495 KEAAEKEQELLRQKQKE----QQQMMEAQERSF--QENIAQLKKKMERERENYMRELRKM 548 KE E+E+EL ++QKE ++QM E +E+ + +E + + ++KM R+ E + ++M Sbjct: 328 KELREQEKEL--REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385 Query: 549 LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEE 589 + K+ ++ E E E L E+ R++EQ + E E Sbjct: 386 REQEQKMRDQ--EERMWEQDERLREKEERMREQEKMWEQVE 424 Score = 48.1 bits (113), Expect = 2e-05 Identities = 49/233 (21%), Positives = 101/233 (43%), Gaps = 25/233 (10%) Query: 375 KSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNI 434 K QE +KK D EK +E+ ++ E + + ++ E + + N+ Sbjct: 431 KMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQ----------EENM 480 Query: 435 YLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAK 494 + + +K+ +Q ++ + E +Q Q + + E+ D+ G++ +Q K Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQE--QEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 538 Query: 495 KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKM------------ERERENYM 542 E + +K ++Q+Q M QE ++ + +KK RERE M Sbjct: 539 MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598 Query: 543 RELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQ 595 RE +M+ + + ++E E +E E + E+ +++EQ E +E ++ Q Sbjct: 599 REEEEMMREQEEKMQE-QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650 Score = 46.2 bits (108), Expect = 9e-05 Identities = 47/233 (20%), Positives = 103/233 (44%), Gaps = 15/233 (6%) Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAEL----------KRLSELLTESIS 422 K++ Q+K+ + +EK +E+ +Q +E + + ++ K++ E Sbjct: 409 KEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMRE 468 Query: 423 RGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALT 482 + N++ + +K+ +Q ++ + E +Q Q + + E+ D+ Sbjct: 469 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE--QEEKIWEQEEKIRDQEEM 526 Query: 483 AGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYM 542 G++ +Q K E + +K ++Q+Q M QE ++ + +KK ++E M Sbjct: 527 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK-TWDQEEKM 585 Query: 543 RELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQ 595 RE +M + K+ EE E +E E + E+ +++EQ E +E + Q Sbjct: 586 REEERMREREKKMREE--EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ 636 Score = 45.1 bits (105), Expect = 2e-04 Identities = 49/260 (18%), Positives = 124/260 (47%), Gaps = 11/260 (4%) Query: 336 QQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFV 395 ++M +Q + D +++ + + ERE E + +++ ++ QK+ + E++++++ Sbjct: 430 KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489 Query: 396 LQN--EEASAKYCQAELKRLSELLTESIS--RGTFFVPGGHNIYLEAKKKIEQDYTLVPR 451 Q E+ + Q +++ E + E R + G +K EQ+ + + Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549 Query: 452 KGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAK-KEAAEKEQELLRQKQK 510 + D+ + + Q + + +++ Q K EK ++ + +E +E+E + ++Q+ Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609 Query: 511 EQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLE-ELLTEGFKEIFE 569 E+ Q E + + +E + + ++KM+ + E + KM + K+ E + L E ++++E Sbjct: 610 EKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWE 669 Query: 570 SLNEEINRLKEQIEAAENEE 589 +++EQ + E EE Sbjct: 670 H-----EKMQEQEKMQEQEE 684 Score = 42.4 bits (98), Expect = 0.001 Identities = 32/120 (26%), Positives = 62/120 (51%), Gaps = 9/120 (7%) Query: 471 EESILQSDKALTAGEKAIAAKQAKKEAAEK----EQELLRQKQ---KEQQQMMEAQERSF 523 EE + + ++ L EK + ++ K E+ + E LR+K+ +EQ++M E E+ Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR 427 Query: 524 QENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIE 583 +E Q ++K R++E M+E ++ + K+ EE E +E E + ++ + EQ E Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE--EETMREQEEKMQKQEENMWEQEE 485 Score = 40.8 bits (94), Expect = 0.004 Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 33/245 (13%) Query: 360 EREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTE 419 +R AV + D+ E K D + + + NEE K AEL+ L Sbjct: 182 QRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKK--NAELQEKLPLAES 239 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 S V E K+K+E+ L+P+ ++E + + ++ Sbjct: 240 EKSEIQLNVK-------ELKRKLERAKFLLPQVQTNT-------------LQEEMWRQEE 279 Query: 480 ALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERE 539 L EK I ++ K E+ K +EQ++ M QE+ +E +L+++ + RE Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE 339 Query: 540 NYMRELRKM------LSHKMKVLEELLTEGFKEIF---ESLNEEINRLKEQIEAAENEEP 590 +ELR+ KM EE + E ++++ E L E+ +++EQ + ++E Sbjct: 340 --QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397 Query: 591 SVFSQ 595 ++ Q Sbjct: 398 RMWEQ 402 Score = 40.4 bits (93), Expect = 0.005 Identities = 53/262 (20%), Positives = 111/262 (42%), Gaps = 28/262 (10%) Query: 336 QQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFV 395 ++M +Q R P + ++L + + E+E + E K QE +K EKK D Sbjct: 652 EKMWEQQRLP-EQKEKLWEHEKMQEQEKM---QEQEEKIWEQEKMEKKTQEQEKKTWDQE 707 Query: 396 LQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVK 455 EE S + + +++ E++ E + +K EQ+ + ++ Sbjct: 708 KMREEESMREREKKMREEEEMMRE-----------------QEEKMQEQEEKMQEQEEEM 750 Query: 456 ADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQM 515 ++ + + Q + + E+ L K EK ++ +++ EQE + Q+E+ + Sbjct: 751 WEQEEKMWEQEEKMWEQQRLPEQK-----EKLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805 Query: 516 MEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKV--LEELLTEGFKEIFESLNE 573 E + R +E + ++KM + E + KM + K+ EE + E + E + E Sbjct: 806 QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMRE 865 Query: 574 EINRLKEQIEAAENEEPSVFSQ 595 + +++ Q E +E + Q Sbjct: 866 QEEKMRGQEEKMREQEEKMRGQ 887 Score = 39.7 bits (91), Expect = 0.009 Identities = 36/164 (21%), Positives = 78/164 (47%), Gaps = 11/164 (6%) Query: 437 EAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKE 496 + K+ EQ+ L +K ++ E +Q Q EE + + ++ + E+ + ++ + Sbjct: 326 QEKELREQEKELREQKELREQE---EQMQEQ---EEKMWEQEEKMREQEEKMWRQEERLW 379 Query: 497 AAEKEQELLRQKQKEQQQMM-EAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKV 555 EK+ QK ++Q++ M E ER ++ +++ E+ MRE +KM + K Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439 Query: 556 LEE----LLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQ 595 ++ E +E + + EE ++EQ E + +E +++ Q Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483 Score = 38.5 bits (88), Expect = 0.019 Identities = 45/229 (19%), Positives = 107/229 (46%), Gaps = 16/229 (6%) Query: 373 KDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGH 432 ++K QE ++K+ + EK +E E+ + Q E + L E + H Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK-----LWEH 670 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKA---DEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 E +K EQ+ + ++ ++ ++ +++ Q ++ EES+ + +K + E+ + Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730 Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSF--QENIAQLKKKM-ERERENYMRELR 546 ++ K + E++ + ++ EQ++ M QE Q+ + + K+K+ E E+ M+E Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEK---MQEQE 787 Query: 547 KMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQ 595 K+ + K+ ++ E + E + + +++ Q E +E ++ Q Sbjct: 788 KIWEQEEKMRDQ--EEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQ 834 Score = 35.8 bits (81), Expect = 0.12 Identities = 29/134 (21%), Positives = 66/134 (49%), Gaps = 20/134 (14%) Query: 471 EESILQSDKALTAGEKAIAAK-----QAKKEAAEKEQELLRQKQKEQQQMMEAQER---- 521 EE + + D+ L E+ + + Q +K EK+ + +K ++Q++ M+ +ER Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455 Query: 522 -----SFQENIAQLKKKMEREREN-YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEI 575 +E + + ++KM+++ EN + +E ++ ++ +E L E E + E+ Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ-----EKMQEQE 510 Query: 576 NRLKEQIEAAENEE 589 ++ EQ E ++E Sbjct: 511 EKIWEQEEKIRDQE 524 >gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sapiens] Length = 1843 Score = 50.8 bits (120), Expect = 4e-06 Identities = 73/326 (22%), Positives = 139/326 (42%), Gaps = 30/326 (9%) Query: 300 LDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVC 359 LD N LEN+ + Q E+ N Q+ ++++ + L++L + Sbjct: 761 LDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSL 820 Query: 360 EREAIAVFMEYSFKDKSQEFQKKLVD----TMEK--------KKEDFVLQNEEASAKYCQ 407 E+E + + +K + ++ + T+E+ +KE+ L E K Sbjct: 821 EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC 880 Query: 408 AELKRLSELLTESISRGTF----FVPGGHNIYLEAKKKIEQDYTL------VPRKGVKAD 457 LK L + E + R T V ++ E K + + L + + G+ + Sbjct: 881 VRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940 Query: 458 EVL---QSFLQSQVVIEESILQSD--KALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQ 512 +L QS S+ + ES L+S K+L E+ IAA +A+ E + + LRQ+ K Sbjct: 941 RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 1000 Query: 513 QQMMEA-QERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESL 571 ++ EA ++R +E + Q + E + RE ++ +KV + L+ + +L Sbjct: 1001 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE--VERNNATL 1058 Query: 572 NEEINRLKEQIEAAENEEPSVFSQIL 597 E LK Q++ E + ++ +QIL Sbjct: 1059 QAEKQALKTQLKQLETQNNNLQAQIL 1084 Score = 39.7 bits (91), Expect = 0.009 Identities = 67/358 (18%), Positives = 140/358 (39%), Gaps = 38/358 (10%) Query: 238 RPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVE 297 R D+ L + VR D+L+S E F A+ + L+E N++ + + Sbjct: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE-----DNQVLLETK 360 Query: 298 TYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHA 357 T L+ G + L + E +A H + R + L E Sbjct: 361 TMLEDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416 Query: 358 VCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELL 417 + +++++ + ++ + +L + +K V NE S++ + E++ S Sbjct: 417 MAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV--NELTSSRLLKLEMENQSLTK 474 Query: 418 TESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQS 477 T R T G+ K +K ++ Q + ++E I+Q Sbjct: 475 TVEELRTTVDSVEGN-----------------ASKILKMEKENQRLSKKVEILENEIVQE 517 Query: 478 DKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 ++L + +K EK E LR+ + Q +++E + + ++ L+++ + Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEI----FE--SLNEEINRLKEQIEAAENEE 589 E ++++ K + K+L E + E ++ FE + +E+ KE+ E AE E Sbjct: 578 AEARVKDIEK----ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELE 631 Score = 35.4 bits (80), Expect = 0.16 Identities = 44/220 (20%), Positives = 98/220 (44%), Gaps = 31/220 (14%) Query: 390 KKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLV 449 K L+N+E ++ + +LK+ ELL S + + +E +++++ Sbjct: 719 KMAQLQLENKELESE--KEQLKKGLELLKASFKKTERLEVSYQGLDIE-NQRLQKTLENS 775 Query: 450 PRKGVKADEVLQSFLQSQVVIEESILQ---SDKALTAGEKAIAAKQAKKEAAEKEQELLR 506 +K + + LQ +++++ + S K L EK + + + EK+++ L Sbjct: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835 Query: 507 QKQKEQQQMMEAQERSFQEN---IAQLKKKME----------------RERENYMRELRK 547 ++ K +Q E ++ + +EN I L+K+ + +E E +EL K Sbjct: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK 895 Query: 548 MLSHKMKVL----EELLTEGFKEIFESLNEEINRLKEQIE 583 + +K L E+L++E K + +N ++ +L ++E Sbjct: 896 RATIDIKTLVTLREDLVSEKLKT--QQMNNDLEKLTHELE 933 Score = 35.0 bits (79), Expect = 0.21 Identities = 66/287 (22%), Positives = 120/287 (41%), Gaps = 41/287 (14%) Query: 300 LDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVC 359 L+ N T +E + E +A+ +Q+++++V E+L+ V Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV--------EILENEIVQ 516 Query: 360 EREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTE 419 E++++ S KD +E + +L T+E +E N E K + E + L++ ++ Sbjct: 517 EKQSLQNCQNLS-KDLMKE-KAQLEKTIETLRE-----NSERQIKILEQENEHLNQTVSS 569 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 R I EA+ K + + + +K S ++ + + L+ K Sbjct: 570 LRQRS--------QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621 Query: 480 ALTAGEKAIAAKQAKKEA--AEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 EK A++ + E EKE ELL++K + E E QEN E E Sbjct: 622 -----EKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQEN-------SELE 669 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEA 584 REN R+L+K L + +L E ++ L+EE L+ +E+ Sbjct: 670 REN--RKLKKTLDSFKNLTFQL--ESLEKENSQLDEENLELRRNVES 712 Score = 35.0 bits (79), Expect = 0.21 Identities = 53/245 (21%), Positives = 104/245 (42%), Gaps = 50/245 (20%) Query: 375 KSQEFQKKLVDTMEKKKEDFVLQNEEASAKY----------------CQAELKRLSELLT 418 K +E K L D++ K E L +E +++Y + E + L + Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203 Query: 419 ESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKA------------DEVLQSFLQS 466 + + + G LE K+EQ+ L+ K + D + ++ S Sbjct: 1204 QLLKQK------GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY--S 1255 Query: 467 QVVIEESILQSD-KALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQ- 524 Q++ E +LQ+D K L + +K E E E + K++ QQ + + + + Q Sbjct: 1256 QLLKETEVLQTDHKNLKS-----LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1310 Query: 525 ENIAQLKKKMERERENYMRELRKMLSHKMKVLE------ELLTEGFKEIFESLNEEINRL 578 E ++QLK +E E + + +++ ++ +LE +L ++ + LN E+ R Sbjct: 1311 ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN-ELRRQ 1369 Query: 579 KEQIE 583 KE++E Sbjct: 1370 KEKLE 1374 Score = 29.6 bits (65), Expect = 8.9 Identities = 30/167 (17%), Positives = 68/167 (40%), Gaps = 23/167 (13%) Query: 453 GVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQK---- 508 G + +E+ S L + +S+ ++ + L ++ +K EKE + L +K Sbjct: 451 GHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510 Query: 509 ------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELR-------------KML 549 +K+ Q + + + AQL+K +E REN R+++ L Sbjct: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570 Query: 550 SHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQI 596 + ++ E + ++ + L+E I ++ E E+ + ++ Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 50.1 bits (118), Expect = 6e-06 Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369 LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V + Sbjct: 2338 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396 Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421 ++ +Q F+K+ + EK +++ ++Q E + + +RL E + E Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2454 Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479 LE +K K++Q+ L+ K + V Q LQ +++S L Sbjct: 2455 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500 Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533 +L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++ Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2558 Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591 E R+ ++ L + + EELL EE RL+EQ++ E + + Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2607 Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616 + +V S A LP +D Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALD 2634 Score = 47.4 bits (111), Expect = 4e-05 Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%) Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 +E A V A+ E + QRA Q +++R + + L V + V +E Sbjct: 1515 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1569 Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429 + + E Q K EK + + LQ E + + E +R ++ E+ Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1620 Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 EA++++E R +KA+E L+ LQ++ V A +K++A Sbjct: 1621 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1658 Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549 +A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L Sbjct: 1659 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1709 Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599 + + +++ TE ++ + L EE+ RL+ + AA + + +++ V Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760 Score = 41.6 bits (96), Expect = 0.002 Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%) Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355 +E L I S A E+ + Q E AA QR + + ++ R + +Q+ L Sbjct: 1944 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1996 Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415 R+ A E E ++L + E++ + +EA+ K QAE K + Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056 Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468 + + E ++ ++Q+ +++ + +A+ E ++ +Q++ Sbjct: 2057 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102 Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528 +S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++ Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2159 Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583 K+ + E E + + + L K +V +EL T E L+EE+ RLK + Sbjct: 2160 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217 Query: 584 AAENEEPSVFSQILDV 599 A + V ++ V Sbjct: 2218 EAARQRSQVEEELFSV 2233 Score = 40.0 bits (92), Expect = 0.007 Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%) Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529 E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q Sbjct: 1366 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424 Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584 L++ E E + R+ ++++ EE L E + E+ L+ + E Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484 Query: 585 AENEE 589 AE ++ Sbjct: 1485 AEAQK 1489 Score = 38.5 bits (88), Expect = 0.019 Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2184 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432 Q+ ++ L+ + EL+RL TE+ + F V Sbjct: 2185 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2233 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 + +E K++ R + D + Q FLQ EE+ A A ++AA+ Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2288 Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544 +A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2348 Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582 ++ ++ ++ EE T+GF+ E+ ++ E RLK ++ Sbjct: 2349 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2389 Score = 37.7 bits (86), Expect = 0.033 Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368 LA+ E Q A Q++A + +R +T Q +LL+ A +REA A Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1746 Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419 K QE + +L + + E+ E S + +AE R EL E Sbjct: 1747 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 + + EAK++ + R+ +A+ VL L + I ++ + Sbjct: 1803 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1847 Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1905 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583 E + L + +V EE+L K FE L E+ R++ E Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1956 Score = 36.2 bits (82), Expect = 0.095 Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%) Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495 E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+ Sbjct: 1506 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1557 Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553 E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + + Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617 Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589 E E +E+ ++ E RL+ Q E ++ Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 50.1 bits (118), Expect = 6e-06 Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369 LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V + Sbjct: 2342 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400 Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421 ++ +Q F+K+ + EK +++ ++Q E + + +RL E + E Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2458 Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479 LE +K K++Q+ L+ K + V Q LQ +++S L Sbjct: 2459 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2504 Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533 +L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++ Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2562 Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591 E R+ ++ L + + EELL EE RL+EQ++ E + + Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2611 Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616 + +V S A LP +D Sbjct: 2612 ALAHSEEVTASQVAATKTLPNGRDALD 2638 Score = 47.4 bits (111), Expect = 4e-05 Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%) Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 +E A V A+ E + QRA Q +++R + + L V + V +E Sbjct: 1519 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1573 Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429 + + E Q K EK + + LQ E + + E +R ++ E+ Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1624 Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 EA++++E R +KA+E L+ LQ++ V A +K++A Sbjct: 1625 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1662 Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549 +A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L Sbjct: 1663 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1713 Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599 + + +++ TE ++ + L EE+ RL+ + AA + + +++ V Sbjct: 1714 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764 Score = 41.6 bits (96), Expect = 0.002 Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%) Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355 +E L I S A E+ + Q E AA QR + + ++ R + +Q+ L Sbjct: 1948 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 2000 Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415 R+ A E E ++L + E++ + +EA+ K QAE K + Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060 Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468 + + E ++ ++Q+ +++ + +A+ E ++ +Q++ Sbjct: 2061 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106 Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528 +S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++ Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2163 Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583 K+ + E E + + + L K +V +EL T E L+EE+ RLK + Sbjct: 2164 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2221 Query: 584 AAENEEPSVFSQILDV 599 A + V ++ V Sbjct: 2222 EAARQRSQVEEELFSV 2237 Score = 40.0 bits (92), Expect = 0.007 Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%) Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529 E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q Sbjct: 1370 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1428 Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584 L++ E E + R+ ++++ EE L E + E+ L+ + E Sbjct: 1429 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1488 Query: 585 AENEE 589 AE ++ Sbjct: 1489 AEAQK 1493 Score = 38.5 bits (88), Expect = 0.019 Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q Sbjct: 2131 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2188 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432 Q+ ++ L+ + EL+RL TE+ + F V Sbjct: 2189 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2237 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 + +E K++ R + D + Q FLQ EE+ A A ++AA+ Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2292 Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544 +A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E Sbjct: 2293 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2352 Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582 ++ ++ ++ EE T+GF+ E+ ++ E RLK ++ Sbjct: 2353 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2393 Score = 37.7 bits (86), Expect = 0.033 Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368 LA+ E Q A Q++A + +R +T Q +LL+ A +REA A Sbjct: 1693 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1750 Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419 K QE + +L + + E+ E S + +AE R EL E Sbjct: 1751 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 + + EAK++ + R+ +A+ VL L + I ++ + Sbjct: 1807 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1851 Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1909 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583 E + L + +V EE+L K FE L E+ R++ E Sbjct: 1910 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1960 Score = 36.2 bits (82), Expect = 0.095 Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%) Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495 E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+ Sbjct: 1510 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1561 Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553 E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + + Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1621 Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589 E E +E+ ++ E RL+ Q E ++ Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1659 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 50.1 bits (118), Expect = 6e-06 Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369 LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V + Sbjct: 2338 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396 Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421 ++ +Q F+K+ + EK +++ ++Q E + + +RL E + E Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2454 Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479 LE +K K++Q+ L+ K + V Q LQ +++S L Sbjct: 2455 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2500 Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533 +L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++ Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2558 Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591 E R+ ++ L + + EELL EE RL+EQ++ E + + Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2607 Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616 + +V S A LP +D Sbjct: 2608 ALAHSEEVTASQVAATKTLPNGRDALD 2634 Score = 47.4 bits (111), Expect = 4e-05 Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%) Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 +E A V A+ E + QRA Q +++R + + L V + V +E Sbjct: 1515 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1569 Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429 + + E Q K EK + + LQ E + + E +R ++ E+ Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1620 Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 EA++++E R +KA+E L+ LQ++ V A +K++A Sbjct: 1621 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1658 Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549 +A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L Sbjct: 1659 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1709 Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599 + + +++ TE ++ + L EE+ RL+ + AA + + +++ V Sbjct: 1710 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760 Score = 41.6 bits (96), Expect = 0.002 Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%) Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355 +E L I S A E+ + Q E AA QR + + ++ R + +Q+ L Sbjct: 1944 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1996 Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415 R+ A E E ++L + E++ + +EA+ K QAE K + Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056 Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468 + + E ++ ++Q+ +++ + +A+ E ++ +Q++ Sbjct: 2057 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102 Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528 +S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++ Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2159 Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583 K+ + E E + + + L K +V +EL T E L+EE+ RLK + Sbjct: 2160 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217 Query: 584 AAENEEPSVFSQILDV 599 A + V ++ V Sbjct: 2218 EAARQRSQVEEELFSV 2233 Score = 40.0 bits (92), Expect = 0.007 Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%) Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529 E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q Sbjct: 1366 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424 Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584 L++ E E + R+ ++++ EE L E + E+ L+ + E Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1484 Query: 585 AENEE 589 AE ++ Sbjct: 1485 AEAQK 1489 Score = 38.5 bits (88), Expect = 0.019 Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2184 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432 Q+ ++ L+ + EL+RL TE+ + F V Sbjct: 2185 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2233 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 + +E K++ R + D + Q FLQ EE+ A A ++AA+ Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2288 Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544 +A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2348 Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582 ++ ++ ++ EE T+GF+ E+ ++ E RLK ++ Sbjct: 2349 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2389 Score = 37.7 bits (86), Expect = 0.033 Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368 LA+ E Q A Q++A + +R +T Q +LL+ A +REA A Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1746 Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419 K QE + +L + + E+ E S + +AE R EL E Sbjct: 1747 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 + + EAK++ + R+ +A+ VL L + I ++ + Sbjct: 1803 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1847 Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1905 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583 E + L + +V EE+L K FE L E+ R++ E Sbjct: 1906 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1956 Score = 36.2 bits (82), Expect = 0.095 Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%) Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495 E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+ Sbjct: 1506 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1557 Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553 E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + + Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617 Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589 E E +E+ ++ E RL+ Q E ++ Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 50.1 bits (118), Expect = 6e-06 Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369 LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V + Sbjct: 2306 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364 Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421 ++ +Q F+K+ + EK +++ ++Q E + + +RL E + E Sbjct: 2365 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2422 Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479 LE +K K++Q+ L+ K + V Q LQ +++S L Sbjct: 2423 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2468 Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533 +L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++ Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2526 Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591 E R+ ++ L + + EELL EE RL+EQ++ E + + Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2575 Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616 + +V S A LP +D Sbjct: 2576 ALAHSEEVTASQVAATKTLPNGRDALD 2602 Score = 47.4 bits (111), Expect = 4e-05 Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%) Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 +E A V A+ E + QRA Q +++R + + L V + V +E Sbjct: 1483 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1537 Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429 + + E Q K EK + + LQ E + + E +R ++ E+ Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1588 Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 EA++++E R +KA+E L+ LQ++ V A +K++A Sbjct: 1589 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1626 Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549 +A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L Sbjct: 1627 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1677 Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599 + + +++ TE ++ + L EE+ RL+ + AA + + +++ V Sbjct: 1678 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728 Score = 41.6 bits (96), Expect = 0.002 Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%) Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355 +E L I S A E+ + Q E AA QR + + ++ R + +Q+ L Sbjct: 1912 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1964 Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415 R+ A E E ++L + E++ + +EA+ K QAE K + Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024 Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468 + + E ++ ++Q+ +++ + +A+ E ++ +Q++ Sbjct: 2025 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070 Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528 +S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++ Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2127 Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583 K+ + E E + + + L K +V +EL T E L+EE+ RLK + Sbjct: 2128 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2185 Query: 584 AAENEEPSVFSQILDV 599 A + V ++ V Sbjct: 2186 EAARQRSQVEEELFSV 2201 Score = 40.0 bits (92), Expect = 0.007 Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%) Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529 E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q Sbjct: 1334 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1392 Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584 L++ E E + R+ ++++ EE L E + E+ L+ + E Sbjct: 1393 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1452 Query: 585 AENEE 589 AE ++ Sbjct: 1453 AEAQK 1457 Score = 38.5 bits (88), Expect = 0.019 Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q Sbjct: 2095 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2152 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432 Q+ ++ L+ + EL+RL TE+ + F V Sbjct: 2153 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2201 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 + +E K++ R + D + Q FLQ EE+ A A ++AA+ Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2256 Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544 +A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E Sbjct: 2257 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2316 Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582 ++ ++ ++ EE T+GF+ E+ ++ E RLK ++ Sbjct: 2317 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2357 Score = 37.7 bits (86), Expect = 0.033 Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368 LA+ E Q A Q++A + +R +T Q +LL+ A +REA A Sbjct: 1657 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1714 Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419 K QE + +L + + E+ E S + +AE R EL E Sbjct: 1715 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1770 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 + + EAK++ + R+ +A+ VL L + I ++ + Sbjct: 1771 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1815 Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1873 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583 E + L + +V EE+L K FE L E+ R++ E Sbjct: 1874 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1924 Score = 36.2 bits (82), Expect = 0.095 Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%) Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495 E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+ Sbjct: 1474 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1525 Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553 E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + + Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1585 Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589 E E +E+ ++ E RL+ Q E ++ Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1623 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 50.1 bits (118), Expect = 6e-06 Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369 LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V + Sbjct: 2475 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533 Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421 ++ +Q F+K+ + EK +++ ++Q E + + +RL E + E Sbjct: 2534 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2591 Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479 LE +K K++Q+ L+ K + V Q LQ +++S L Sbjct: 2592 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2637 Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533 +L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++ Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2695 Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591 E R+ ++ L + + EELL EE RL+EQ++ E + + Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2744 Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616 + +V S A LP +D Sbjct: 2745 ALAHSEEVTASQVAATKTLPNGRDALD 2771 Score = 47.4 bits (111), Expect = 4e-05 Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%) Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 +E A V A+ E + QRA Q +++R + + L V + V +E Sbjct: 1652 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1706 Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429 + + E Q K EK + + LQ E + + E +R ++ E+ Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1757 Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 EA++++E R +KA+E L+ LQ++ V A +K++A Sbjct: 1758 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1795 Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549 +A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L Sbjct: 1796 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1846 Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599 + + +++ TE ++ + L EE+ RL+ + AA + + +++ V Sbjct: 1847 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897 Score = 41.6 bits (96), Expect = 0.002 Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%) Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355 +E L I S A E+ + Q E AA QR + + ++ R + +Q+ L Sbjct: 2081 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 2133 Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415 R+ A E E ++L + E++ + +EA+ K QAE K + Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193 Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468 + + E ++ ++Q+ +++ + +A+ E ++ +Q++ Sbjct: 2194 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239 Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528 +S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++ Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2296 Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583 K+ + E E + + + L K +V +EL T E L+EE+ RLK + Sbjct: 2297 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2354 Query: 584 AAENEEPSVFSQILDV 599 A + V ++ V Sbjct: 2355 EAARQRSQVEEELFSV 2370 Score = 40.0 bits (92), Expect = 0.007 Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%) Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529 E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q Sbjct: 1503 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1561 Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584 L++ E E + R+ ++++ EE L E + E+ L+ + E Sbjct: 1562 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1621 Query: 585 AENEE 589 AE ++ Sbjct: 1622 AEAQK 1626 Score = 38.5 bits (88), Expect = 0.019 Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q Sbjct: 2264 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2321 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432 Q+ ++ L+ + EL+RL TE+ + F V Sbjct: 2322 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2370 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 + +E K++ R + D + Q FLQ EE+ A A ++AA+ Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2425 Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544 +A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E Sbjct: 2426 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2485 Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582 ++ ++ ++ EE T+GF+ E+ ++ E RLK ++ Sbjct: 2486 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2526 Score = 37.7 bits (86), Expect = 0.033 Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368 LA+ E Q A Q++A + +R +T Q +LL+ A +REA A Sbjct: 1826 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1883 Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419 K QE + +L + + E+ E S + +AE R EL E Sbjct: 1884 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1939 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 + + EAK++ + R+ +A+ VL L + I ++ + Sbjct: 1940 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1984 Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 2042 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583 E + L + +V EE+L K FE L E+ R++ E Sbjct: 2043 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 2093 Score = 36.2 bits (82), Expect = 0.095 Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%) Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495 E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+ Sbjct: 1643 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1694 Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553 E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + + Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754 Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589 E E +E+ ++ E RL+ Q E ++ Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 50.1 bits (118), Expect = 6e-06 Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369 LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V + Sbjct: 2316 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374 Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421 ++ +Q F+K+ + EK +++ ++Q E + + +RL E + E Sbjct: 2375 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2432 Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479 LE +K K++Q+ L+ K + V Q LQ +++S L Sbjct: 2433 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2478 Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533 +L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++ Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2536 Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591 E R+ ++ L + + EELL EE RL+EQ++ E + + Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2585 Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616 + +V S A LP +D Sbjct: 2586 ALAHSEEVTASQVAATKTLPNGRDALD 2612 Score = 47.4 bits (111), Expect = 4e-05 Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%) Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 +E A V A+ E + QRA Q +++R + + L V + V +E Sbjct: 1493 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1547 Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429 + + E Q K EK + + LQ E + + E +R ++ E+ Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1598 Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 EA++++E R +KA+E L+ LQ++ V A +K++A Sbjct: 1599 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1636 Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549 +A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L Sbjct: 1637 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1687 Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599 + + +++ TE ++ + L EE+ RL+ + AA + + +++ V Sbjct: 1688 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738 Score = 41.6 bits (96), Expect = 0.002 Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%) Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355 +E L I S A E+ + Q E AA QR + + ++ R + +Q+ L Sbjct: 1922 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1974 Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415 R+ A E E ++L + E++ + +EA+ K QAE K + Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034 Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468 + + E ++ ++Q+ +++ + +A+ E ++ +Q++ Sbjct: 2035 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080 Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528 +S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++ Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2137 Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583 K+ + E E + + + L K +V +EL T E L+EE+ RLK + Sbjct: 2138 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2195 Query: 584 AAENEEPSVFSQILDV 599 A + V ++ V Sbjct: 2196 EAARQRSQVEEELFSV 2211 Score = 40.0 bits (92), Expect = 0.007 Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%) Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529 E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q Sbjct: 1344 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1402 Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584 L++ E E + R+ ++++ EE L E + E+ L+ + E Sbjct: 1403 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1462 Query: 585 AENEE 589 AE ++ Sbjct: 1463 AEAQK 1467 Score = 38.5 bits (88), Expect = 0.019 Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q Sbjct: 2105 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2162 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432 Q+ ++ L+ + EL+RL TE+ + F V Sbjct: 2163 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2211 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 + +E K++ R + D + Q FLQ EE+ A A ++AA+ Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2266 Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544 +A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E Sbjct: 2267 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2326 Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582 ++ ++ ++ EE T+GF+ E+ ++ E RLK ++ Sbjct: 2327 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2367 Score = 37.7 bits (86), Expect = 0.033 Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368 LA+ E Q A Q++A + +R +T Q +LL+ A +REA A Sbjct: 1667 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1724 Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419 K QE + +L + + E+ E S + +AE R EL E Sbjct: 1725 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 + + EAK++ + R+ +A+ VL L + I ++ + Sbjct: 1781 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1825 Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1883 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583 E + L + +V EE+L K FE L E+ R++ E Sbjct: 1884 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1934 Score = 36.2 bits (82), Expect = 0.095 Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%) Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495 E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+ Sbjct: 1484 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1535 Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553 E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + + Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595 Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589 E E +E+ ++ E RL+ Q E ++ Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 50.1 bits (118), Expect = 6e-06 Identities = 73/327 (22%), Positives = 139/327 (42%), Gaps = 58/327 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQVRFPTDTL----QELLDVHAVCEREAIAVF----ME 369 LAQ E + +Q +QQ+A++ + TL Q L++ A ER + V + Sbjct: 2324 LAQ-EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382 Query: 370 YSFKDKSQEFQKKLVDTMEK--------KKEDFVLQNEEASAKYCQAELKRLSELLTESI 421 ++ +Q F+K+ + EK +++ ++Q E + + +RL E + E Sbjct: 2383 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE-- 2440 Query: 422 SRGTFFVPGGHNIYLEAKK-KIEQDYTLVPRKGVKADEVLQS-FLQSQVVIEESILQSDK 479 LE +K K++Q+ L+ K + V Q LQ +++S L Sbjct: 2441 --------------LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKD 2486 Query: 480 ALTAGEKAIAAKQAK------KEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKK 533 +L E+ I ++AK E A+ +Q Q++++QQ ME + + ++ + +++ Sbjct: 2487 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQ--MEQERQRLVASMEEARRR 2544 Query: 534 MERERENYMRELRKM--LSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPS 591 E R+ ++ L + + EELL EE RL+EQ++ E + + Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEELLA-----------EENQRLREQLQLLEEQHRA 2593 Query: 592 VFSQILDVAGSIFIA--ALPGAAKLVD 616 + +V S A LP +D Sbjct: 2594 ALAHSEEVTASQVAATKTLPNGRDALD 2620 Score = 47.4 bits (111), Expect = 4e-05 Identities = 63/291 (21%), Positives = 128/291 (43%), Gaps = 47/291 (16%) Query: 311 LENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEY 370 +E A V A+ E + QRA Q +++R + + L V + V +E Sbjct: 1501 VELASRVKAEAEAAREKQRAL-----QALEELRLQAEEAERRLRQAEVERARQVQVALET 1555 Query: 371 SFKDKSQEFQKKLVDTMEKKKE-DFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVP 429 + + E Q K EK + + LQ E + + E +R ++ E+ Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEA--------- 1606 Query: 430 GGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIA 489 EA++++E R +KA+E L+ LQ++ V A +K++A Sbjct: 1607 --ERAREEAERELE-------RWQLKANEALRLRLQAEEV-------------AQQKSLA 1644 Query: 490 AKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKML 549 +A+K+ E E+E R++ K ++Q + +E + QE +E++R+ ++ L Sbjct: 1645 QAEAEKQKEEAERE-ARRRGKAEEQAVRQRELAEQE--------LEKQRQLAEGTAQQRL 1695 Query: 550 SHKMKVLE-ELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILDV 599 + + +++ TE ++ + L EE+ RL+ + AA + + +++ V Sbjct: 1696 AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1746 Score = 41.6 bits (96), Expect = 0.002 Identities = 62/316 (19%), Positives = 132/316 (41%), Gaps = 38/316 (12%) Query: 296 VETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355 +E L I S A E+ + Q E AA QR + + ++ R + +Q+ L Sbjct: 1930 LELELGRIRSNA----EDTLRSKEQAELEAARQR---QLAAEEERRRREAEERVQKSLAA 1982 Query: 356 HAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSE 415 R+ A E E ++L + E++ + +EA+ K QAE K + Sbjct: 1983 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2042 Query: 416 LLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKAD-------EVLQSFLQSQV 468 + + E ++ ++Q+ +++ + +A+ E ++ +Q++ Sbjct: 2043 AVQQKEQ--------------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088 Query: 469 VIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIA 528 +S Q ++A + A QA+ +A ++L ++ ++E + +A++ + ++ Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ--- 2145 Query: 529 QLKKKMERERENYMRELRKMLSHKMKVLEELLT-----EGFKEIFESLNEEINRLKEQIE 583 K+ + E E + + + L K +V +EL T E L+EE+ RLK + Sbjct: 2146 --KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2203 Query: 584 AAENEEPSVFSQILDV 599 A + V ++ V Sbjct: 2204 EAARQRSQVEEELFSV 2219 Score = 40.0 bits (92), Expect = 0.007 Identities = 32/125 (25%), Positives = 61/125 (48%), Gaps = 8/125 (6%) Query: 472 ESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE--RSFQENIAQ 529 E+ L+ + L A A A QA++EA E +Q + + + ++ ++AQ+ RS QE + Q Sbjct: 1352 EAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1410 Query: 530 LKKKMERERENYMRELRKMLSHKMKVLEE-----LLTEGFKEIFESLNEEINRLKEQIEA 584 L++ E E + R+ ++++ EE L E + E+ L+ + E Sbjct: 1411 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEE 1470 Query: 585 AENEE 589 AE ++ Sbjct: 1471 AEAQK 1475 Score = 38.5 bits (88), Expect = 0.019 Identities = 58/285 (20%), Positives = 121/285 (42%), Gaps = 43/285 (15%) Query: 319 AQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQE 378 A+ + AA ++ Q+ A++ + L++ A E E F E + + K+Q Sbjct: 2113 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA--EMEKHKKFAEQTLRQKAQV 2170 Query: 379 FQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES------ISRGTFFVPGGH 432 Q+ ++ L+ + EL+RL TE+ + F V Sbjct: 2171 EQELTTLRLQ-------LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2219 Query: 433 NIYLEAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAK 491 + +E K++ R + D + Q FLQ EE+ A A ++AA+ Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-----EEAEKMKQVAEEAARLSVAAQ 2274 Query: 492 QAKKEAAEKEQELLRQK-------QKEQQQMMEAQERSFQENIAQLKKKMERERENYMRE 544 +A + E++L +Q+ +++ Q + EA + + Q +K++ +E+ ++E Sbjct: 2275 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2334 Query: 545 LRKMLSHKMKVLEELLTEGFKEIFES-------LNEEINRLKEQI 582 ++ ++ ++ EE T+GF+ E+ ++ E RLK ++ Sbjct: 2335 DKEQMAQQL--AEE--TQGFQRTLEAERQRQLEMSAEAERLKLRV 2375 Score = 37.7 bits (86), Expect = 0.033 Identities = 68/293 (23%), Positives = 117/293 (39%), Gaps = 52/293 (17%) Query: 318 LAQCENSAAVQRAANHYSQQMAQQ---VRFPTDTLQ-----ELLDVH-AVCEREAIAVFM 368 LA+ E Q A Q++A + +R +T Q +LL+ A +REA A Sbjct: 1675 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA-- 1732 Query: 369 EYSFKDKSQEFQKKLVDTMEK---------KKEDFVLQNEEASAKYCQAELKRLSELLTE 419 K QE + +L + + E+ E S + +AE R EL E Sbjct: 1733 ----TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1788 Query: 420 SISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDK 479 + + EAK++ + R+ +A+ VL L + I ++ + Sbjct: 1789 AARLRA--------LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA-------IGEATR 1833 Query: 480 ALTAGEKAIAAKQAKKEAAEK--EQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERE 537 T E A+ K+A+ E + E E ++++ E+Q + +E +AQL+K + E Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD--IEERLAQLRKASDSE 1891 Query: 538 RENYMRELRKMLSHKMKVLEELLTEGFKEIFE-------SLNEEINRLKEQIE 583 E + L + +V EE+L K FE L E+ R++ E Sbjct: 1892 LERQKGLVEDTLRQRRQVEEEIL--ALKASFEKAAAGKAELELELGRIRSNAE 1942 Score = 36.2 bits (82), Expect = 0.095 Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 13/158 (8%) Query: 437 EAKKKIEQDYTLVPRKGVKAD-EVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKK 495 E+++K + + L R VKA+ E + ++ +EE LQ+++A E+ + +QA+ Sbjct: 1492 ESQRKRQAEVELASR--VKAEAEAAREKQRALQALEELRLQAEEA----ERRL--RQAEV 1543 Query: 496 EAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER--ENYMRELRKMLSHKM 553 E A + Q L Q+ + ++++ SF E AQL++ ++ E +RE + + + Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1603 Query: 554 KVLEELLTEGFKEI--FESLNEEINRLKEQIEAAENEE 589 E E +E+ ++ E RL+ Q E ++ Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1641 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.131 0.369 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,773,572 Number of Sequences: 37866 Number of extensions: 1006071 Number of successful extensions: 13563 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 291 Number of HSP's successfully gapped in prelim test: 850 Number of HSP's that attempted gapping in prelim test: 6825 Number of HSP's gapped (non-prelim): 4243 length of query: 638 length of database: 18,247,518 effective HSP length: 109 effective length of query: 529 effective length of database: 14,120,124 effective search space: 7469545596 effective search space used: 7469545596 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.