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Search of human proteins with 146260271
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|146260271 hypothetical protein LOC129881 [Homo sapiens]
(552 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|146260271 hypothetical protein LOC129881 [Homo sapiens] 1094 0.0
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 99 1e-20
gi|148746195 trichohyalin [Homo sapiens] 98 2e-20
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 95 1e-19
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 91 3e-18
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 90 5e-18
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 90 6e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 89 1e-17
gi|219803769 trichoplein [Homo sapiens] 87 4e-17
gi|14150056 trichoplein [Homo sapiens] 87 4e-17
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 86 9e-17
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 84 3e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 84 3e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 84 3e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 84 3e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 84 3e-16
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 84 4e-16
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 1e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 81 2e-15
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 81 2e-15
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 81 2e-15
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 81 2e-15
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 81 2e-15
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 81 2e-15
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 81 2e-15
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 81 2e-15
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 80 4e-15
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 80 4e-15
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 79 1e-14
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 79 1e-14
>gi|146260271 hypothetical protein LOC129881 [Homo sapiens]
Length = 552
Score = 1094 bits (2829), Expect = 0.0
Identities = 552/552 (100%), Positives = 552/552 (100%)
Query: 1 MDTSSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQD 60
MDTSSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQD
Sbjct: 1 MDTSSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQD 60
Query: 61 SLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQ 120
SLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQ
Sbjct: 61 SLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQ 120
Query: 121 ILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIK 180
ILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIK
Sbjct: 121 ILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIK 180
Query: 181 SDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDA 240
SDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDA
Sbjct: 181 SDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDA 240
Query: 241 EEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKF 300
EEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKF
Sbjct: 241 EEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKF 300
Query: 301 IKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWE 360
IKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWE
Sbjct: 301 IKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWE 360
Query: 361 KREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEK 420
KREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEK
Sbjct: 361 KREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEK 420
Query: 421 KCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIE 480
KCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIE
Sbjct: 421 KCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIE 480
Query: 481 LESETTNKYIYPLVKAVQEGPGGGRGPVFVDRGGLRPSYQANDVTGVQLPFYNSQGPKYN 540
LESETTNKYIYPLVKAVQEGPGGGRGPVFVDRGGLRPSYQANDVTGVQLPFYNSQGPKYN
Sbjct: 481 LESETTNKYIYPLVKAVQEGPGGGRGPVFVDRGGLRPSYQANDVTGVQLPFYNSQGPKYN 540
Query: 541 FQKSKRRLGFTW 552
FQKSKRRLGFTW
Sbjct: 541 FQKSKRRLGFTW 552
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 99.0 bits (245), Expect = 1e-20
Identities = 99/474 (20%), Positives = 229/474 (48%), Gaps = 49/474 (10%)
Query: 53 DEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRD 112
++ K+I+ +++ R+ LR + +E + K ++EQ+ E ++++
Sbjct: 283 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQK- 341
Query: 113 EEIEAERQILDLEEEIYKQGKRKKAIEN---AKQYQFYQTERVKNFHSGLLLSRV--MKE 167
E E E Q+ + EE++++Q ++ + E ++ + ++ E+ + + M E
Sbjct: 342 ELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401
Query: 168 RDAQIEFRKSKIK-SDKKWEEQLKLNIEKAFKEEQEKA---------EKRHRERVALAKD 217
+D ++ ++ +++ +K WE+ K+ EK +E+++K E+R RER ++
Sbjct: 402 QDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE 461
Query: 218 HLKQIKEHEE----EEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFL 273
+ ++E EE +EE + EEK+ ++ + ++ ++K++++ E++ E +
Sbjct: 462 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 521
Query: 274 EHM----QDKHIIKAVEQQQQE----EEDEKMR----KFIKAKKRLIQMGKEKEAETHRL 321
+ Q+K + + + ++QE E++EKMR K ++R+ + +E+E +T
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581
Query: 322 MEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYR 381
EK RE + E K+ + E+M+ R+ E E E++ +E++EK + + + E
Sbjct: 582 EEKMRE--EERMREREKKMREEEEMM--REQEEKMQEQEEKMQEQEEKMWEQEEKMQEQE 637
Query: 382 AIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEK-----------EKKCKADKEHQE 430
+ + +E+ Q + ++Q L K + WEHEK EK + +K ++
Sbjct: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQK--EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
Query: 431 VQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
Q+ + + K +++ + R E ++ E+E++ Q+ ++ E E E
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEE 749
Score = 92.8 bits (229), Expect = 7e-19
Identities = 103/470 (21%), Positives = 215/470 (45%), Gaps = 71/470 (15%)
Query: 19 KESTEIRNSEE----------DQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTRE 68
+E E+R EE +Q + K+ Q+ + ++ R Q+ R E
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 69 AACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKR----DEEIEAERQILDL 124
+ ER +KE +R QE K W +E+K++ ++K+ +E+++ E +I +
Sbjct: 398 RMWEQDERLREKEERMREQE--KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Query: 125 EEEIYKQGKRKKAIENAKQYQF----------YQTERVKNFHSGLLLSRVMKERDAQIEF 174
E+++ ++ + + E Q Q +Q +R+ L M+E++ +I
Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWE 515
Query: 175 RKSKIKS---------------------DKKWEEQLKL-NIEKAFKEEQEKAEKRHRERV 212
++ KI+ D+ WE++ K+ + E+ +++E+ EK+ +E+
Sbjct: 516 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQE 575
Query: 213 ALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRF 272
D ++++E E ER KK E+ EE+ R E +K++++ E+M E +
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREE--EEMMR-------EQEEKMQEQEEKMQEQEEKM 626
Query: 273 LEH---MQDKHIIKAVEQQQQEEEDEKM---RKFIKAKKRLIQMGKEKEAETHRLMEKR- 325
E MQ++ ++++ E++EKM ++ + K++L + K +E E + E++
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686
Query: 326 --RERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRE---REKDEKNKAELKTIAEY 380
+E++ E K+ D E M + E E + + E RE++EK + + + + E
Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ 746
Query: 381 RAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQE 430
+ + +E+ Q + ++Q L K + WEHEK ++ + E +E
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQK--EKLWEHEKMQEQEKIWEQEE 794
Score = 82.8 bits (203), Expect = 7e-16
Identities = 97/430 (22%), Positives = 200/430 (46%), Gaps = 64/430 (14%)
Query: 92 HWTNTYAGMKEQKLEA----KKKRD---EEIEAERQILDLE---EEIYKQGKRKKAIENA 141
H + +AG ++ L A KK D EE+ ER L LE I + +KK E
Sbjct: 172 HHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ 231
Query: 142 KQYQFYQTER------VKNFHSGL-----LLSRVM----------KERDAQIEFRKSKIK 180
++ ++E+ VK L LL +V +E + + + +K + +
Sbjct: 232 EKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 291
Query: 181 SDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDA 240
+K W ++ +L ++ EQE+ R +R+ ++ K+++E E+E +K+ E++
Sbjct: 292 EEKMWRQEERLREQEGKMREQEEKMWRQEKRL---REQEKELREQEKELREQKELREQEE 348
Query: 241 EEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKF 300
+ +++ ++E E +K+ ++ E+M R E +++Q E+++KMR
Sbjct: 349 QMQEQEEKMWEQE--EKMREQEEKMWRQEERLWE-----------QEKQMREQEQKMRD- 394
Query: 301 IKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWE 360
++R+ + + + R+ E+ E++ + ++ +EK E RD E E E
Sbjct: 395 --QEERMWEQDERLREKEERMREQ--EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE-E 449
Query: 361 KREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEK-- 418
+R RE+++K + E +T+ E + K +E Q + E ++Q L K + WE EK
Sbjct: 450 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK--EKLWEQEKMQ 507
Query: 419 EKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREV 478
E++ K ++ ++++D + + K +Q K E E + E+E++ +D +++
Sbjct: 508 EQEEKIWEQEEKIRDQE-EMWGQEKKMWRQEKMRE------QEDQMWEQEEKMRDQEQKM 560
Query: 479 IELESETTNK 488
+ E K
Sbjct: 561 WDQEERMEKK 570
Score = 82.8 bits (203), Expect = 7e-16
Identities = 108/507 (21%), Positives = 227/507 (44%), Gaps = 62/507 (12%)
Query: 43 DLQQVTIIPHDEWKRIQDSLDRLTREAACLRAE---------RKAKKEMHLRSQEVVKHW 93
+LQ+ K+ ++ LT+E L E KK L+ + +
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 94 TNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGK----RKKAIENAKQYQFYQT 149
+ + ++L+ K +R + + + Q L+EE+++Q + ++K I ++ + Q
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
Query: 150 ERVKNFHSGLL--------LSRVMKERDAQIEFRKSKIKSDKKW---EEQLKLNIEKAFK 198
ER++ + + ++E++ ++ ++ +++ K+ EEQ++ EK ++
Sbjct: 300 ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWE 359
Query: 199 EEQ---EKAEKRHRERVALAKDHLKQIKEHEE----EEERRKKYEEK---DAEEIKRQNA 248
+E+ E+ EK R+ L + KQ++E E+ +EER + +E+ E ++ Q
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQE-KQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Query: 249 LYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLI 308
++E + + EKK +E + R E MQ++ I+ E++ +EEE+ + K +K+
Sbjct: 419 MWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEE 478
Query: 309 QMGK--EKEAETHRLMEKRRERIHNFLSELLKEKL--------DNEDMI-----IARDIA 353
M + EKE + RL E++ + + +EK+ D E+M + R
Sbjct: 479 NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 538
Query: 354 EAEAE---WEKREREKDEKNKA-------ELKTIAEYRAIVMKNKE--EEERQRKIEAKE 401
E E WE+ E+ +D++ K E KT + + + ++ EEER R+ E K
Sbjct: 539 MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
+ M +Q E+E+K + +E Q+ +Q+ + + ++ + + +
Sbjct: 599 REEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQ 658
Query: 462 ALVAEKEKEFQDYAREVIELESETTNK 488
L +KEK ++ + E E K
Sbjct: 659 RLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Score = 77.8 bits (190), Expect = 2e-14
Identities = 99/451 (21%), Positives = 205/451 (45%), Gaps = 52/451 (11%)
Query: 54 EWKRIQDSLDRLTREAACLRA--ERKAKKEMHLRSQEVVKHWTNTYAGMKEQKL---EAK 108
E +RI++ ++ E +R E+ K+E ++ QE K W +++KL E
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE-KEWQQQRLPEQKEKLWEQEKM 506
Query: 109 KKRDEEI-EAERQILDLEEEIYKQGK---RKKAIENAKQYQFYQTERVKNFHSGLLLSRV 164
++++E+I E E +I D +EE++ Q K R++ + + + Q E++++ +
Sbjct: 507 QEQEEKIWEQEEKIRD-QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565
Query: 165 MKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQE----KAEKRHRERVALAKDHLK 220
E+ Q + +K+ + +K EE+ EK +EE+E + EK + + + K
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
Query: 221 QIKEHEEEEERRKKYEEKDAEEIKRQNALYEI----EMRKKL-----EKKREEMHESRRR 271
++ E+ +E+ +K E++ + +++ ++E E ++KL +++E+M E +
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 272 FLEHMQDKHIIKAVEQ------QQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKR 325
E Q+K K EQ Q++ E+E MR+ K + +M +E+E + EK
Sbjct: 686 IWE--QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKM 743
Query: 326 RERIHNFLSELLK-----EKL--------DNEDMIIARDIAEAEAEWEKREREKDEKNKA 372
+E+ + K EK+ E + + E E WE+ E+ +D++ K
Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM 803
Query: 373 ELKTIAEYRAIVMKNKEEEER----QRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEH 428
+ + R K + +EE+ + K+ +E+ + + E + E+K + +E
Sbjct: 804 RGQE-EKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEK 862
Query: 429 QEVQDAHI--QQMAKNKFNAKQAKQAELDYC 457
Q+ + Q+ + K Q E YC
Sbjct: 863 MREQEEKMRGQEEKMREQEEKMRGQEEKIYC 893
Score = 70.1 bits (170), Expect = 5e-12
Identities = 70/337 (20%), Positives = 173/337 (51%), Gaps = 30/337 (8%)
Query: 53 DEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRD 112
++ K+ D +++ E E+K ++E + ++ K M+EQ+ + +++ +
Sbjct: 573 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK--------MQEQEEKMQEQEE 624
Query: 113 EEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQI 172
+ E E ++ + EE++++Q ++ E + ++ +R+ L M+E++
Sbjct: 625 KMWEQEEKMQEQEEKMWEQEEKMWEQEE----KMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
Query: 173 EFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE-EER 231
E ++ KI +K E++ + +K + +E+ + E+ RER ++ + ++E EE+ +E+
Sbjct: 681 E-QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQ 739
Query: 232 RKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEH--MQDKHIIKAVEQQQ 289
+K +E++ E +++ ++E E K E++R + E + + EH MQ++ I E++
Sbjct: 740 EEKMQEQEEEMWEQEEKMWEQE-EKMWEQQR--LPEQKEKLWEHEKMQEQEKIWEQEEKM 796
Query: 290 QEEE------DEKMR---KFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEK 340
+++E +EKMR + ++ ++ + +EK M + E++ E ++EK
Sbjct: 797 RDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWG-QEEKMEEK 855
Query: 341 LDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTI 377
+ ++ + R+ E E++ RE++EK + + + I
Sbjct: 856 MQGQEEKM-REQEEKMRGQEEKMREQEEKMRGQEEKI 891
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 98.2 bits (243), Expect = 2e-20
Identities = 100/457 (21%), Positives = 225/457 (49%), Gaps = 43/457 (9%)
Query: 53 DEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAK--KK 110
++ +R + +L E R +++ ++E L E K+++LE + ++
Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE--------KQERLEQRDRQR 168
Query: 111 RDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDA 170
RDEE+ +RQ EE + ++ ++ + + +F E+++ L + +E+
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228
Query: 171 QIEFRKSKI---KSDKKWEEQ---LKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKE 224
Q R+ ++ + +K+W ++ L+ EK +EE ++ + E L K ++++
Sbjct: 229 QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRR 288
Query: 225 HEEEEE------RRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
+EEE RR++ + EE +R+ + E R++ +++RE+ E R + L Q+
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERRE----QQEERREQQERREQQEERREQQLRREQE 344
Query: 279 KHIIKAVEQQQQEE-EDEKMRKFIKAKKRLIQMGKE----KEAETHRLMEKRRERIHNFL 333
+ + + ++Q+EE ++++R+ + ++R Q+ +E +E + R + RRE+
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 334 SELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAE--LKTIAEYRAIVMKNKEEE 391
+L +E+ + + R+ + E+R +K E+ + E LK E R +K +EE
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Query: 392 ERQRKIEAKEQLLAVMKADQIFWEHEKEKKCK-ADKEHQEVQDAHIQQMAKNKFNAKQAK 450
ER + K+QL K DQ E +E+ K ++E +E Q+ QQ+ + + ++ +
Sbjct: 465 ERHEQERRKQQL----KRDQ--EEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518
Query: 451 -QAELDYCRLTEALVAEKE--KEFQDYAREVIELESE 484
+ + + RL + L +E++ +E ++ ++++ E E
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Score = 98.2 bits (243), Expect = 2e-20
Identities = 83/415 (20%), Positives = 201/415 (48%), Gaps = 21/415 (5%)
Query: 45 QQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQK 104
+++ + +E + ++ +L E L+ +++ ++ R + + +
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 105 LEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRV 164
L AK E++ E+Q+L EEE ++ +R+K ++ Q+ + E+++ LL
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 165 MKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKE 224
K R + E + K K ++ EEQL EE EK ++ RE+ ++ L+Q +E
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQL-------LGEEPEKRRRQEREKKYREEEELQQEEE 1001
Query: 225 HEEEEERRKKYEEKDAEEIKRQNALYEIE---MRKKLEKKREEMHESRRRFLEHMQDKHI 281
EER K+ ++ + ++++ L + E +R++ EK+R + E + R E +Q +
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE- 1060
Query: 282 IKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKL 341
EQ EE + + R+ ++ + R + +++E + R ++R R +E+L
Sbjct: 1061 ----EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 342 DNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
E+ + R+ E EKR R++ E+ E + + + +++ + E+ R++++E +
Sbjct: 1117 QQEEEQLLRE------EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDY 456
+ ++ ++ E+++K + ++E Q ++ +Q+ + + + ++++L +
Sbjct: 1171 REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225
Score = 97.1 bits (240), Expect = 4e-20
Identities = 103/450 (22%), Positives = 216/450 (48%), Gaps = 35/450 (7%)
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLR---SQEVVKHWTNTYAGMKEQKLEAKKK 110
E + ++ L +L R+ LR ER+ +++ R Q++ + +E++ E +++
Sbjct: 270 ELQEEEEQLRKLERQE--LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 111 RDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDA 170
R+++ E Q L E+E ++ + ++ E ++ Q + E+ + L R+
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 171 QIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEE 230
Q+ R+ +++ +++ + +L E+ + EQ+ ++ R + H +Q E E E+
Sbjct: 388 QLR-REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH-EQKHEQERREQ 445
Query: 231 RRKKYEEKDAEEIKRQNALYEIEM-RKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R K+ +E+ + +KR+ E R+K + KR++ E R R+L+ +++ + ++Q
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 290 Q-EEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMII 348
Q E E+ R ++RL +++ E RL ++ R +L +E+ + + ++
Sbjct: 506 QLRREQEERR-----EQRL-----KRQEEEERLQQRLRSE-----QQLRREQEERREQLL 550
Query: 349 ARDIAEAEAEWEKRE----REKDEKNKAELKTIAEYRAIVMKNKEEE--ERQRKIEAKEQ 402
R+ E E E+RE RE++E+ LK E R +K ++EE E++ K E E+
Sbjct: 551 KRE-EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609
Query: 403 LLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAK--QAKQAELDYCRLT 460
L + +Q E E++ + E Q+ QQ + + + Q + E + RL
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669
Query: 461 EALVAEKEKEFQDYAREVIELESETTNKYI 490
+ L E E+E ++ +E+ E E E + I
Sbjct: 670 QRLKREHEEERRE--QELAEEEQEQARERI 697
Score = 94.7 bits (234), Expect = 2e-19
Identities = 97/478 (20%), Positives = 224/478 (46%), Gaps = 48/478 (10%)
Query: 20 ESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAK 79
+ E R +EE+Q+ + P +E R ++ L+ L R+ + +++ +
Sbjct: 181 QEREERRAEEEQL-------QSCKGHETEEFPDEEQLRRRELLE-LRRKGREEKQQQRRE 232
Query: 80 KEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIE 139
++ + +E K W +++ E +K ++EE + +R++ + EE++ K +++ E
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRK---EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 140 NAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKE 199
++ Q Q +R++ L + +ER Q E R+ + + ++ EE+ + + + +E
Sbjct: 290 RQEEEQ--QQQRLRREQQ--LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 200 EQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLE 259
+E+ +R +E + ++ +E E++ R++ + + ++++R+ L + ++ +
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 260 KKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIK--AKKRLIQMGKEKEAE 317
+ R E R + L Q + E+ +Q+ E E+ + +K ++R + +E+E E
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 318 THRLMEKRRERIHNFLSELLKE---KLDNEDMIIARDIAEAEAEWEKRE----REKDEKN 370
H E+R++++ E +E KL+ E E + E+RE RE++E+
Sbjct: 466 RHE-QERRKQQLKRDQEEERRERWLKLEEE---------ERREQQERREQQLRREQEERR 515
Query: 371 KAELKTIAEYRAIVMKNKEEEE-RQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQ 429
+ LK E + + + E++ R+ + E +EQLL + E+EK+ + ++ Q
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL----------KREEEKRLEQERREQ 565
Query: 430 EV---QDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
+ Q+ Q+ K + +Q + RL + L E+ + + R L+ E
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623
Score = 92.0 bits (227), Expect = 1e-18
Identities = 95/428 (22%), Positives = 208/428 (48%), Gaps = 49/428 (11%)
Query: 64 RLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKL--EAKKKRDEEIEAERQI 121
+L RE R E++ ++E LR ++ ++ +EQ+L E + +R++++ E+Q
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLR---------REQQLRREQQLRREQQLRREQQ- 412
Query: 122 LDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQI--------- 172
L E+++ ++ + ++ E + Q ++ ER + L R +ER +
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQ-----RLKREQEERRDWLKREEETERH 467
Query: 173 --EFRKSKIKSDKKWEEQ---LKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEE 227
E RK ++K D++ E + LKL E+ ++++ + ++ RE+ + LK+ +E E
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527
Query: 228 EEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQ 287
++R + ++ E+ +R+ L + E K+LE++R E R + E +D+ + + E+
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ--EERRDQLLKREEER 585
Query: 288 QQQE---EEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLK--EKLD 342
+QQ E++E++ + +K ++ ++ +++E RL KR E +LLK E+ +
Sbjct: 586 RQQRLKREQEERLEQRLKREE--VERLEQEERREQRL--KREEPEEERRQQLLKSEEQEE 641
Query: 343 NEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQ 402
+ R+ E + KRE E++E+ + LK E + EEE+ Q + K +
Sbjct: 642 RRQQQLRREQQERREQRLKRE-EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 403 LLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEA 462
+ + W+ E E + K + + Q+ + + ++ +++EL + A
Sbjct: 701 I------PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Query: 463 LVAEKEKE 470
++E+E
Sbjct: 755 HRQQQEEE 762
Score = 91.7 bits (226), Expect = 2e-18
Identities = 93/403 (23%), Positives = 196/403 (48%), Gaps = 67/403 (16%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R E++ ++E LR ++ E++ E + KR EE E +Q L E+++ ++
Sbjct: 496 RREQQERREQQLRREQ-------------EERREQRLKRQEEEERLQQRLRSEQQLRREQ 542
Query: 133 --KRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQI-----EFRKSKIKSDKKW 185
+R++ ++ ++ + Q R + L R +ER Q+ E R+ ++K +++
Sbjct: 543 EERREQLLKREEEKRLEQERREQR------LKREQEERRDQLLKREEERRQQRLKREQEE 596
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR 245
+ +L E+ + EQE+ ++ +R ++ +Q+ + EE+EERR++ ++ +E +R
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE-RR 655
Query: 246 QNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKK 305
+ L E ++LE++ + HE RR EQ+ EEE E+ R+ IK++
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERR--------------EQELAEEEQEQARERIKSRI 701
Query: 306 RLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRER- 364
Q E EA+ + R R E + + + E+ R E+E +W++ ER
Sbjct: 702 PKWQWQLESEADARQSKVYSRPR----KQEGQRRRQEQEEK---RRRRESELQWQEEERA 754
Query: 365 -----EKDEKN------KAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIF 413
E++++ +AE K+ + + + E+R+R++ A+E+ + +Q F
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER----QQREQRF 810
Query: 414 W--EHEKEKKCKADKEHQ-EVQDAHIQQMAKNKFNAKQAKQAE 453
E EKE++ + +E + E+Q ++ + + A+Q ++ E
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE 853
Score = 88.2 bits (217), Expect = 2e-17
Identities = 99/499 (19%), Positives = 228/499 (45%), Gaps = 83/499 (16%)
Query: 53 DEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRD 112
+E ++++ R RE L ER+ E L QE + + ++ Q+ + +K R+
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQERE---EQQLHRQERDRKFLEEEQQLRRQERD-RKFRE 1505
Query: 113 EEI---EAERQILDLEEEIYKQGKRKKAIENAKQYQ---------------FYQTERVKN 154
+E+ E ER+ L+ E+++++Q +++K ++ +Q + F + E+++
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 155 FHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVAL 214
LSR +ERD + + K++ ++ E+ F E++++ ++ ++ L
Sbjct: 1566 EREEQQLSR--QERDRKFRLEEQKVRRQEQ---------ERKFMEDEQQLRRQEGQQ-QL 1613
Query: 215 AKDHLKQIKEHE----EEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRR 270
++ ++ +E E E EE++ +E+D + ++ + L E ++L R+
Sbjct: 1614 RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Query: 271 RFLEHMQDKHI------IKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEK 324
+ L+ +++ + K E++QQ E+ RKF++ +++L + E++ + +
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733
Query: 325 RRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIV 384
E+ E ++ L+ E + R+ E + R +E+D K + E + E
Sbjct: 1734 ETEQEQLRRQERYRKILEEEQLRPERE------EQQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 385 MKNKE------EEERQRKIEAKEQLLAVMKADQIFWE------HEKEKKCKADKEHQEVQ 432
++++E EEE+ R+ ++QL + + WE E+E++ + +++ Q
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRA 1847
Query: 433 DAHIQQMAKNK------FNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESETT 486
+ K++ + ++ K+ + +L E + ++KE Q + R+V E++S
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH-RQVGEIKS--- 1903
Query: 487 NKYIYPLVKAVQEGPGGGR 505
QEG G GR
Sbjct: 1904 -----------QEGKGHGR 1911
Score = 87.4 bits (215), Expect = 3e-17
Identities = 115/486 (23%), Positives = 221/486 (45%), Gaps = 76/486 (15%)
Query: 56 KRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI 115
K++Q ++L E R R+ ++E R +E ++ +EQ L ++++
Sbjct: 964 KKLQQKEEQLLGEEPEKR--RRQEREKKYREEEELQQ-------EEEQLLREEREKRRRQ 1014
Query: 116 EAERQI-----LDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDA 170
E ERQ L EEE + +R+K ++ Q+ + E ++ LL +ER+
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL----GEERET 1070
Query: 171 QIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEH---EE 227
+ R+ +++ + EE+L+ E+ +EE EK ++ RER ++ L+Q +E EE
Sbjct: 1071 R---RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Query: 228 EEERRKK-----Y-EEKDAEEIKRQNALYEIEMRKKLEKKR-----EEMHESRRRFLEHM 276
E+RR++ Y EE++ ++ + Q E E R++ E +R EE+ + + L
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187
Query: 277 QDKHIIKAVEQQQQEEE-----------DEKMRKFIK-----AKKRLIQMG----KEKEA 316
Q+K + Q ++EEE DE R +K K+ ++ K +E
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 317 ETHRLMEK---RRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAE 373
E R +E R + L LL E+ + RD + W++R+R E+ + E
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQE-------RDREQERRRWQQRDRHFPEEEQLE 1300
Query: 374 LKTIAEYRAIVMKNKEE-----EERQRKIEAKEQLLAVMKADQIFWEHEKE--KKCKADK 426
+ E + K++EE EER+ K +E + +Q+ E E++ ++ + D+
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Query: 427 EHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE---ALVAEKEKEF-QDYAREVIELE 482
+ +E + H +Q K ++ ++ E + L E E+E++ QD R+ E E
Sbjct: 1361 KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 483 SETTNK 488
+ + +
Sbjct: 1421 QQLSRQ 1426
Score = 85.5 bits (210), Expect = 1e-16
Identities = 94/442 (21%), Positives = 201/442 (45%), Gaps = 33/442 (7%)
Query: 55 WKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEE 114
W+ + R+ R + ++E LR++E + +E++ E ++++ E
Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP--EEEEKEQRRRQRRE 826
Query: 115 IEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQT-----ERVKNFHSGLLLSRVMKERD 169
E E Q L+ EE++ ++ + ++ E Q Q E+ ++ L K R
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886
Query: 170 AQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEH---E 226
+ + + + +K ++ L+ E+ +EE+EK ++ +ER ++ L+Q +E E
Sbjct: 887 HTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946
Query: 227 EEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVE 286
E E+RR++ E+ + K+ E + ++ EK+R + E + R E +Q + E
Sbjct: 947 EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Query: 287 QQQQEEEDEKMRKFIKAKKRLIQMGKEK----EAETHRLMEKRRERIHNFLSELLKEKLD 342
++++ E R++ KK +Q +E+ E E RL E RER + EL +E+
Sbjct: 1007 EREKRRRQEWERQY--RKKDELQQEEEQLLREEREKRRLQE--RERQYREEEELQQEE-- 1060
Query: 343 NEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQ 402
E ++ E E++ R+++E + E + + E + + +ER+R+ +E+
Sbjct: 1061 -EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP----EKRRRQERERQCREEEE 1115
Query: 403 LLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEA 462
L + ++ E+EK+ + + E Q ++ +QQ + + K+ + R
Sbjct: 1116 L---QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER---- 1168
Query: 463 LVAEKEKEFQDYAREVIELESE 484
+E+E Q +++ E E
Sbjct: 1169 -QYREEEELQQEEEQLLREEQE 1189
Score = 85.1 bits (209), Expect = 2e-16
Identities = 84/403 (20%), Positives = 197/403 (48%), Gaps = 30/403 (7%)
Query: 59 QDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAE 118
++ L+R ++ A R +RK+++E L +E + K ++ E + EE
Sbjct: 1296 EEQLEREEQKEA-KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 119 RQILDL---EEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFR 175
RQ D EEE+ Q + +K +E ++ + + ER + F L + ++ ++ + + R
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLR--RQERERKF---LKEEQQLRCQEREQQLR 1409
Query: 176 KSKIKSDKKWEEQL-KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKK 234
+ + + ++ E+QL + ++ F+EE+++ ++ RER L ++ + + H + E +
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESR-RRFLEH--MQDKHIIKAVEQQQQE 291
+E++ +++ RQ RK LE++++ + R R+F E + K +E++QQ
Sbjct: 1470 LQEREEQQLHRQE-----RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 292 EEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARD 351
++ RKF++ +++L R ++R++R F E + + + E+ ++R
Sbjct: 1525 HRQQRQRKFLQEEQQL--------RRQERGQQRRQDRDRKFREE-EQLRQEREEQQLSRQ 1575
Query: 352 IAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQ 411
+ + E+++ + E+ + ++ + R + + +ER RK EQLL + Q
Sbjct: 1576 ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635
Query: 412 IFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAEL 454
+ H +E+ K +E +++ +Q ++ + K ++ +L
Sbjct: 1636 L---HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQL 1675
Score = 84.3 bits (207), Expect = 3e-16
Identities = 115/496 (23%), Positives = 218/496 (43%), Gaps = 82/496 (16%)
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKK-----EMHLRSQEVVKHWTNTYAG-----MKEQ 103
EW+R D L +E L E + K+ E R +E ++ G + Q
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 104 KLEAKKKRDEEI------------------EAERQI-----LDLEEEIYKQGKRKKAIEN 140
+LE + +++EE+ E ERQ L EEE + +R+K
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 141 AKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEE 200
+ Q+ + E V+ LL R+ + R+ +++ + EE+L+ E+ +EE
Sbjct: 1135 ELERQYREEEEVQQEEEQLL-------REEPEKRRRQELERQYREEEELQQEEEQLLREE 1187
Query: 201 QEKA----EKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
QEK E+++RE L + KQ E++ K E + E R N +Y +
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY---CKG 1244
Query: 257 KLEKKREEMHESRRRFLEHMQD-KHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKE 315
+ ++ ++ +S+ R + QD +H++ EQQ+++ E E+ R ++R +E++
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLG--EQQERDREQERRRW----QQRDRHFPEEEQ 1298
Query: 316 AETHRLME-KRRERIHNFLSELLKEKLDNEDMIIARD--------IAEAEAEWEKREREK 366
E E KRR+R +LL+E+ + + D + + E R +E+
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 367 DEKNKAE--------LKTIAEYRAIVMKNKE----EEERQRKIEAKEQLLAVMKADQIFW 414
D K + E K + E + + + +E +EE+Q + + +EQ L D+ F
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR-QDRDRKFR 1417
Query: 415 EHEKE-KKCKADKEHQEVQDAHIQQMAKNKF--NAKQAKQAELDYCRLTEALVAEKEKE- 470
E E++ + + D++ +E + +Q + KF +Q +Q R E L+ E+E++
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 471 --FQDYAREVIELESE 484
Q+ R+ +E E +
Sbjct: 1478 LHRQERDRKFLEEEQQ 1493
Score = 84.0 bits (206), Expect = 3e-16
Identities = 103/497 (20%), Positives = 218/497 (43%), Gaps = 72/497 (14%)
Query: 19 KESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKA 78
+E E R +E + Y +V ++ ++ + KR + L+R RE L+ E +
Sbjct: 1125 REEREKRRRQELERQYRE--EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQ 1182
Query: 79 --KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDE------EIEAERQILDLEEEIYK 130
++E R QE + + ++++ + + D+ + E E++ + ++Y
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYC 1242
Query: 131 QGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLK 190
+G+ + + Q + ++ L +ERD + E R+ W+++ +
Sbjct: 1243 KGRENEQFRQLEDSQLRDRQSQQDLQH---LLGEQQERDREQERRR--------WQQRDR 1291
Query: 191 LNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEE-----IKR 245
E+ E +E+ E + R+R + + L ++E EE+ RR++ + K EE +
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDRKSQEEKQL--LREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 246 QNALYEIEMRKKLEKKREEMHESRRRFLEHMQ-------DKHIIKAVEQQQQEEEDEKM- 297
+ L E +K ++ E R+FLE Q ++ +K +Q + +E ++++
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR 1409
Query: 298 ----RKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSE-----------------L 336
RKF + +++L + ++++ +R+ER FL E L
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Query: 337 LKEKLDNEDMIIARDIAEAEAEWEKREREKDEK-NKAELKTIAEYRAIVMKNKE--EEER 393
L+E+ + + RD E E + R +E+D K + EL++ R + + ++ ++R
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Query: 394 QRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAE 453
QRK +EQ L + Q + +++ K +E Q Q+ QQ+++ + + K
Sbjct: 1530 QRKFLQEEQQLRRQERGQ---QRRQDRDRKFREEEQLRQEREEQQLSRQERDRK------ 1580
Query: 454 LDYCRLTEALVAEKEKE 470
RL E V +E+E
Sbjct: 1581 ---FRLEEQKVRRQEQE 1594
Score = 58.2 bits (139), Expect = 2e-08
Identities = 55/273 (20%), Positives = 131/273 (47%), Gaps = 17/273 (6%)
Query: 198 KEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKK 257
+E+Q + E R R+ +Q K E+E E + E+ + +E Q + ++
Sbjct: 116 EEDQRRFEPRDRQLEEEPGQRRRQ-KRQEQERELAEGEEQSEKQERLEQRDRQRRD--EE 172
Query: 258 LEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAE 317
L ++R+E E R E Q + ++ +EE + R+ ++ +++ G+E++
Sbjct: 173 LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRK----GREEK-- 226
Query: 318 THRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTI 377
++RRER E +++ + ++ ++ + + E +R+RE E+ + K
Sbjct: 227 ----QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK-- 280
Query: 378 AEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQ 437
E + + + +EEE++Q+++ ++QL K ++ E ++E++ + ++ Q+ + Q
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLR--RKQEEERREQQEERREQQERREQQEERREQQ 338
Query: 438 QMAKNKFNAKQAKQAELDYCRLTEALVAEKEKE 470
+ + +Q + E + R + L E+E+E
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEE 371
Score = 54.3 bits (129), Expect = 3e-07
Identities = 74/319 (23%), Positives = 149/319 (46%), Gaps = 49/319 (15%)
Query: 19 KESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTR--EAACLRAER 76
+E ++ E D+ +L P ++ + HD ++ ++ L E R ER
Sbjct: 1631 REEQQLHRQERDRK-FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 77 KAK---KEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGK 133
K +E LR QE + + ++ Q+LE K + +E++ E + +E++ +Q +
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE----QEQLRRQER 1745
Query: 134 RKKAIENAK------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
+K +E + + Q + ER + F L + +E+ + + +SD+K+ E
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ------ESDRKFRE 1799
Query: 188 QLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQN 247
E+ ++E+E+ + R ++R + +Q++ EE+E+R + E + Q
Sbjct: 1800 ------EEQLRQEREEQQLRPQQRDGKYRWEEEQLQL--EEQEQRLRQERDRQYRAEEQF 1851
Query: 248 ALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRL 307
A E R++ E +EE E +RR Q++ E++ +EE +R+ K ++R
Sbjct: 1852 ATQEKSRREEQELWQEE--EQKRR-----QER------ERKLREEH---IRRQQKEEQRH 1895
Query: 308 IQMG--KEKEAETH-RLME 323
Q+G K +E + H RL+E
Sbjct: 1896 RQVGEIKSQEGKGHGRLLE 1914
Score = 53.5 bits (127), Expect = 5e-07
Identities = 47/243 (19%), Positives = 110/243 (45%), Gaps = 37/243 (15%)
Query: 226 EEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAV 285
+EE++RR + ++ EE Q ++R++ E R E + + +
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQ-------------RRRQKRQEQERELAEGEEQSEKQERL 161
Query: 286 EQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNED 345
EQ+ ++ DE++ + +++ Q +E+ AE +L + F E E+L +
Sbjct: 162 EQRDRQRRDEELWR----QRQEWQEREERRAEEEQLQSCKGHETEEFPDE---EQLRRRE 214
Query: 346 MIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMK-----NKEEEERQRKIEAK 400
++ R E + ++RER+ + E K + ++ K +EE +RQR+++ +
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 401 EQLLAVMKADQIFWEHEKEK------------KCKADKEHQEVQDAHIQQMAKNKFNAKQ 448
E+ L ++ ++ E ++E+ + K ++E +E Q+ +Q + + ++
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 449 AKQ 451
+Q
Sbjct: 335 REQ 337
Score = 30.0 bits (66), Expect = 5.8
Identities = 37/167 (22%), Positives = 77/167 (46%), Gaps = 21/167 (12%)
Query: 321 LMEKRRERIHNFLSELLKEKLDNEDM--IIARDIAEAEAEWEKREREKDEKNKAELKTIA 378
L E++R R S LL+++ ED RD + E E +R R+K ++ + EL
Sbjct: 95 LDEEKRARCDGKES-LLQDRRQEEDQRRFEPRD-RQLEEEPGQRRRQKRQEQEREL---- 148
Query: 379 EYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQ 438
+ +E+ E+Q ++E +++ + D+ W +E + + ++ +E Q +
Sbjct: 149 ------AEGEEQSEKQERLEQRDR----QRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 439 MAKNKF-NAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
+F + +Q ++ EL L EK+++ ++ V + E E
Sbjct: 199 HETEEFPDEEQLRRREL--LELRRKGREEKQQQRRERQDRVFQEEEE 243
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 95.1 bits (235), Expect = 1e-19
Identities = 94/432 (21%), Positives = 211/432 (48%), Gaps = 38/432 (8%)
Query: 41 KVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGM 100
K+ + I +E R Q+ R E + E +KE +R QE + W
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM-WEKEEKMR 366
Query: 101 KEQKL----EAKKKRDEEI--EAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKN 154
+++++ E K +R EE+ E E +I +LEE++++Q K ++ E ++ + + + +
Sbjct: 367 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 426
Query: 155 FHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEK----RHRE 210
+ + K R+ + + R+ + K W ++ K++ ++ +EE+++ E+ R E
Sbjct: 427 EQEAKMWRQEEKIREQEEKIREQE---KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 483
Query: 211 RVALAKDHLKQIKEHEEEEERRKKYEEK---DAEEIKRQNALYEIEMRKKLEKKREEMHE 267
++ ++ +Q ++ E+EE+ +K EEK E+I+ Q E +K+ ++ E++ E
Sbjct: 484 KIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR-EQEEKMWRQEEKIRE 542
Query: 268 SRRRFLEHMQDKHIIKAVEQQQQEEEDEKM----------RKFIKAKKRLIQMGKEKEAE 317
+ E + K E+++++E+++KM + + ++ I+ +EK E
Sbjct: 543 QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 318 THRLMEKRRERIHNFLSELLK--EKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAELK 375
M K+ E+I ++ + EK+ ++ I R+ E E E++ E++EK + +
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI-REQEEMTQEQEEKMGEQEEKMCEQEE 661
Query: 376 TIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHE------KEKKCKADKEHQ 429
+ E M +EE+ R+++ + +EQ + + +++ E E +EK C+ +++ Q
Sbjct: 662 KMQEQEE-TMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 720
Query: 430 EVQDAHIQQMAK 441
E ++ +Q K
Sbjct: 721 EQEEKMRRQEEK 732
Score = 87.8 bits (216), Expect = 2e-17
Identities = 109/509 (21%), Positives = 246/509 (48%), Gaps = 56/509 (11%)
Query: 17 RAKESTEIRNSEEDQV-LYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAE 75
+ +E ++ SE+ ++ L + L K++ ++ ++P + +Q D L +E + A+
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKL-LLPQQQ---LQAEADHLGKELQSVSAK 280
Query: 76 RKAKKEMH-----LRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI--EAERQILDLEEEI 128
+A+ E + L Q+ K W K Q+ E K + EE E E +I + EE++
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEE---KIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 129 YKQGK----RKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKS-KIKS-D 182
+Q + +++ + ++ + + E+++ + R ++ + K KI+ +
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 397
Query: 183 KKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHE---EEEERRKKYEEK- 238
+K EQ K+ + EE+ + E++ RE+ + K ++ E E+EE+ ++ E+K
Sbjct: 398 EKMHEQEKIREQ----EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 453
Query: 239 --DAEEIKRQNALYEIEMRKKLE---KKREEMHES----RRRFLEHMQDKHIIKAVE--- 286
E+I Q + E E R++ E ++ E++HE R++ H Q++ I K E
Sbjct: 454 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVW 513
Query: 287 ------QQQQE---EEDEKMRKFIKAKKRLIQMGKEKEA--ETHRLMEKRRERIHNFLSE 335
++Q+E E++EKM + + + +M +E+E E ++ E+ + +
Sbjct: 514 RQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 336 LLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQR 395
+EK+ ++ + R + + EKR+ ++++ K E K + I + ++ E++
Sbjct: 574 RQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE 633
Query: 396 KIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELD 455
KI +E++ + ++ E E EK C+ +++ QE ++ +Q K + K+ ++ E +
Sbjct: 634 KIREQEEM--TQEQEEKMGEQE-EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE-E 689
Query: 456 YCRLTEALVAEKEKEFQDYAREVIELESE 484
R E ++ E+E++ + ++ E E +
Sbjct: 690 KIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Score = 81.6 bits (200), Expect = 2e-15
Identities = 79/374 (21%), Positives = 185/374 (49%), Gaps = 49/374 (13%)
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDE 113
E ++I++ R +EA R E K +++ ++ K W +++K+ ++KR E
Sbjct: 415 EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQE 474
Query: 114 EIEAERQILDL--EEEIYKQGKR----KKAIENAKQYQFYQTERVKNFHSGLLLSRVMKE 167
+ E RQ + +EEI++Q ++ ++ I ++ + Q E+++ + +E
Sbjct: 475 QEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKI------RE 528
Query: 168 RDAQIEFRKSKIKSDKK-WEEQLKLNI-EKAFKEE--QEKAEKRHRERVALAKDHLKQIK 223
++ ++ ++ KI+ ++ W E+ K++ EK ++EE QE+ +K R+ + + K +
Sbjct: 529 QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588
Query: 224 EHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIK 283
+ E+ E+ +K +E++ + K++ + E E + + ++++ E + R E M + K
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEK 648
Query: 284 AVEQQQQE-EEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLD 342
EQ+++ E++EKM++ + R + +E+E + EK RE+ E+++E
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQ-----EEMMQE--- 700
Query: 343 NEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQ 402
+ E WE+ E+ +++ K M+ +EE+ R+++ + EQ
Sbjct: 701 -----------QEEKMWEQEEKMCEQEEK-------------MQEQEEKMRRQEEKMWEQ 736
Query: 403 LLAVMKADQIFWEH 416
+ + + ++ EH
Sbjct: 737 EVRLRQQEEKMQEH 750
Score = 55.8 bits (133), Expect = 1e-07
Identities = 55/292 (18%), Positives = 138/292 (47%), Gaps = 26/292 (8%)
Query: 198 KEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEK--DAEEIKRQNALYEIEMR 255
K+ E+ +ER AL+ + + EE +E+ K +EK E K + L E++
Sbjct: 189 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 248
Query: 256 KKLEKKREEMHESR-RRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK 314
+KLE+ + + + + + +H+ + + + Q Q EE+E + + ++ + +EK
Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 315 EAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAEL 374
E ++++ E+I +EK+ ++ + R + E WEK E+ + ++
Sbjct: 309 IQEWEEKIQEQEEKIRE-----QEEKIREQEEKMRR---QEEMMWEKEEKMRRQEE---- 356
Query: 375 KTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQE--VQ 432
+M KEE+ R+++ E+ + + +++ WE E++ + +K H++ ++
Sbjct: 357 ---------MMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR 407
Query: 433 DAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
+ ++ + K ++ +Q + E + E+E++ ++ +++ E +
Sbjct: 408 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 459
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 90.9 bits (224), Expect = 3e-18
Identities = 86/393 (21%), Positives = 201/393 (51%), Gaps = 50/393 (12%)
Query: 54 EWK-RIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKL----EAK 108
EW+ +IQ+ +++ + +R ++E +R QE + W +++++ E K
Sbjct: 372 EWEEKIQEQEEKIREQEEKIR-----EQEEKMRRQEEMM-WEKEEKMRRQEEMMWEKEEK 425
Query: 109 KKRDEEI--EAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK 166
+R EE+ E E +I +LEE++++Q K ++ E ++ + + + + + + K
Sbjct: 426 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 485
Query: 167 ERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHE 226
R+ + + R+ + +K W ++ K++ ++ +EE+++ E+ R ++I+E E
Sbjct: 486 IREQEEKIRE---QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWR------QEEKIREQE 536
Query: 227 EEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVE 286
E +++K E++ E+I++Q +K+ ++ E+MH+ + E Q++ + + E
Sbjct: 537 EIWRQKEKIHEQE-EKIRKQ--------EEKMWRQEEKMHDQEEKIRE--QEEKVWRQEE 585
Query: 287 Q-QQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNED 345
+ ++QEE+ + + I+ ++ + Q +EK E M ++ E++ +EK+ ++
Sbjct: 586 KIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE-----QEEKMRRQE 640
Query: 346 MIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLA 405
E E EK+ RE++EK + + + + E M +EE+ +++ + +EQ
Sbjct: 641 --------EKIREQEKKIREQEEKIREQEEMMQEQEE-KMWEQEEKMCEQEEKMQEQEEK 691
Query: 406 VMKADQIFWEHEKEKKCKADK--EHQEVQDAHI 436
+ + ++ WE E + + +K EHQE +A I
Sbjct: 692 MRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 84.3 bits (207), Expect = 3e-16
Identities = 105/488 (21%), Positives = 225/488 (46%), Gaps = 74/488 (15%)
Query: 17 RAKESTEIRNSEEDQV-LYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAE 75
+ +E ++ SE+ ++ L + L K++ ++ ++P + +Q D L +E + A+
Sbjct: 286 KLQEKLQLVESEKSEIQLNVKELKRKLERAKL-LLPQQQ---LQAEADHLGKELQSVSAK 341
Query: 76 RKAKKEMH-----LRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI--EAERQILDLEEEI 128
+A+ E + L Q+ K W K Q+ E K + EE E E +I + EE++
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEE---KIQEWEEKIQEQEEKIREQEEKIREQEEKM 398
Query: 129 YKQGK----RKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKK 184
+Q + +++ + ++ + + E+++ +M E++ +I + K+ +K
Sbjct: 399 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRR------QEEMMWEKEEKIRELEEKMHEQEK 452
Query: 185 WEEQLKLNIEKAFKEEQEKAEK------RHRERVALAKDHLKQIKEHEEEEERRKKYEEK 238
EQ + E+ EQEK ++ R E++ ++ +++ +E +E + +EK
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK 512
Query: 239 DAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQ-QQEEEDEKM 297
EE KRQ + EM ++ EK RE+ R++ H Q++ I K E+ +QEE+
Sbjct: 513 IREEEKRQE---QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQ 569
Query: 298 RKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEA 357
+ I+ ++ + +EK E + ++ E+I +E++ E + E
Sbjct: 570 EEKIREQEEKVWRQEEKIREQEEKIREQEEKIRE------QEEMTQEQEEKMGEQEEKMC 623
Query: 358 EWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHE 417
E E++ +E++EK M+ +EE+ R+++ + +EQ + + +++ E E
Sbjct: 624 EQEEKMQEQEEK---------------MRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 668
Query: 418 ------KEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEF 471
+EK C+ +++ QE ++ +Q K + +Q E EK +E
Sbjct: 669 EKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE------------EKMQEH 716
Query: 472 QDYAREVI 479
Q++ I
Sbjct: 717 QEHLEAAI 724
Score = 82.4 bits (202), Expect = 1e-15
Identities = 111/476 (23%), Positives = 224/476 (47%), Gaps = 63/476 (13%)
Query: 52 HDEWK---RIQDSLDRL-TREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD WK ++ +L + T++ R + KE S E+ ++ T T +KE+ +
Sbjct: 229 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKEKNAKL 287
Query: 108 KKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKE 167
++K + +E+E+ + L K+ KRK +E AK Q + + H G L V +
Sbjct: 288 QEKL-QLVESEKSEIQLN---VKELKRK--LERAKLLLPQQQLQAEADHLGKELQSVSAK 341
Query: 168 RDAQIEF-----RKSKIKSDKKW-----------------------EEQLKLNIEKAFKE 199
AQ+E R ++ + +K W EE+++ EK ++
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 200 EQ---EKAEKRHRERVALAKDHLKQIKEHE---EEEERRKKYEEK--DAEEIKRQNALYE 251
E+ EK EK R+ + + K ++ E E+EE+ ++ EEK + E+I+ Q
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE---- 457
Query: 252 IEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQ-QQQEEEDEKMRKFIKAKKRLIQM 310
E R++ EK RE+ + Q++ I + E+ ++QEE+ + + I ++++ +
Sbjct: 458 -EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREE 516
Query: 311 GKEKE-AETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEK 369
K +E E R EK RE+ + KEK+ ++ I + + E W + E+ D++
Sbjct: 517 EKRQEQEEMWRQEEKIREQEEIWRQ---KEKIHEQEEKIRK---QEEKMWRQEEKMHDQE 570
Query: 370 NKAELKTIAEYR-AIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEH 428
K + +R ++ +EE+ R+++ + +EQ + ++ E E EK C+ +++
Sbjct: 571 EKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE-EKMCEQEEKM 629
Query: 429 QEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
QE ++ +Q K + K+ ++ E + R E ++ E+E++ + ++ E E +
Sbjct: 630 QEQEEKMRRQEEKIREQEKKIREQE-EKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 90.1 bits (222), Expect = 5e-18
Identities = 93/440 (21%), Positives = 210/440 (47%), Gaps = 54/440 (12%)
Query: 57 RIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIE 116
++++ +++ R+ LR + K +E +E K ++EQ+ + +++ ++ E
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQEKELREQKK--------LREQEEQMQEQEEKMWE 321
Query: 117 AERQILDLEEEIYKQGKR----KKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQI 172
E ++ + EE++++Q +R +K + +Q Q ER M E+D ++
Sbjct: 322 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER-------------MWEQDERL 368
Query: 173 EFRKSKIKSDKK-WEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEER 231
++ +++ +K WE++ K+ E+ +E ++K R E ++ Q +E E+
Sbjct: 369 REKEERMREQEKMWEQEEKMQEEERIREREKKM--REEEETMREQEEKMQKQEENMWEQE 426
Query: 232 RKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHM-QDKHIIKAVEQQQQ 290
K+++++ E K + L+E E ++ E+K E E R E Q+K + + + ++Q
Sbjct: 427 EKEWQQQRLPEQKEK--LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 291 E----EEDEKMR----KFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLD 342
E E++EKMR K ++R+ + + + R+ E+++ + ++ +EK
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKK--MWQQEEKMREEKKT 542
Query: 343 NEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAK-- 400
E D E E E+R RE+++K + E + + E K +E+EE+ R+ E K
Sbjct: 543 QEQEKKTWDQEEKMRE-EERMREREKKMREEEEMMREQEE---KMQEQEEKMREQEEKMW 598
Query: 401 -------EQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAE 453
EQ + + ++ WE E+E K + +E Q+ +Q+ + + ++ + +
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 454 LDYCRLTEALVAEKEKEFQD 473
+ R E + +E++ ++
Sbjct: 659 EEKMREQEEKMQGQEEKMRE 678
Score = 86.7 bits (213), Expect = 5e-17
Identities = 97/484 (20%), Positives = 233/484 (48%), Gaps = 40/484 (8%)
Query: 19 KESTEIRNSEEDQV-LYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERK 77
+E + SE+ ++ L + L K++ + ++P + +Q+ + R E + +
Sbjct: 193 QEKLRLAESEKSEIQLNVKELKRKLERAKF-LLPQVQTNTLQEEMWRQEEELREQEKKIR 251
Query: 78 AKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
++E R +E ++ M+EQ+ + +++ E E+++ + E+E+ +Q K ++
Sbjct: 252 KQEEKMWRQEERLREQEGK---MREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQ 308
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKI----KSDKKWEEQLKLNI 193
E ++ + E+ + M+E++ ++ ++ ++ K ++ E++++
Sbjct: 309 EEQMQEQEEKMWEQEEK----------MREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 358
Query: 194 EKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIE 253
E+ +++++ EK R R ++ + + +E +EEER ++ E+K EE + E
Sbjct: 359 ERMWEQDERLREKEERMR---EQEKMWEQEEKMQEEERIREREKKMREEEETMR-----E 410
Query: 254 MRKKLEKKREEMHE-SRRRFLEHMQDKHIIKAVEQQQQEEEDEKM-RKFIKAKKRLIQMG 311
+K++K+ E M E + + + + K EQ++ +E++EK+ + K + + G
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Query: 312 KEKEAETHRLMEKRRERI---HNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK-- 366
+EK+ M ++ +++ + + ++ D E+ + +D E E RE++K
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMW 530
Query: 367 --DEKNKAELKTIAEYRAIVMKNKE--EEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC 422
+EK + E KT + + + ++ EEER R+ E K + M +Q E+E+K
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 590
Query: 423 KADKEHQEVQDAHIQQMAKNKF--NAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIE 480
+ +E Q+ +Q+ + + K +Q E D + E ++ E+E++ Q+ ++ E
Sbjct: 591 REQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWE 650
Query: 481 LESE 484
E +
Sbjct: 651 QEEK 654
Score = 80.1 bits (196), Expect = 5e-15
Identities = 84/356 (23%), Positives = 174/356 (48%), Gaps = 42/356 (11%)
Query: 54 EWKRIQDSLDRLTREAACLRA--ERKAKKEMHLRSQEVVKHWTNTYAGMKEQKL---EAK 108
E +RI++ ++ E +R E+ K+E ++ QE K W +++KL E
Sbjct: 390 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE-KEWQQQRLPEQKEKLWEQEKM 448
Query: 109 KKRDEEI-EAERQILDLEEEIYKQGK---RKKAIENAKQYQFYQTERVKNFHSGLL-LSR 163
++++E+I E E +I D +EE++ Q K R++ + + + Q E++++ +
Sbjct: 449 QEQEEKIWEQEEKIRD-QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 507
Query: 164 VMKERDAQIEFRKSKIKSDKK-WEEQLKLNIEKAFKEEQEKA---------EKRHRERVA 213
M E+D ++ ++ +++ KK W+++ K+ EK +E+++K E+R RER
Sbjct: 508 RMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREK 567
Query: 214 LAKDHLKQIKEHEE----EEERRKKYEEKDAEEIKR-----------QNALYEIEMRKKL 258
++ + ++E EE +EE+ ++ EEK E+ ++ + ++E E K+
Sbjct: 568 KMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKM 627
Query: 259 EKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAET 318
+++ E M E E MQ++ ++++ E++EKMR+ + + + +E+E +
Sbjct: 628 QEQEEMMWEQE----EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683
Query: 319 HRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEW-EKREREKDEKNKAE 373
EK RE+ + K E M + + E EK ER +D+K K +
Sbjct: 684 QGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQ 739
Score = 79.7 bits (195), Expect = 6e-15
Identities = 87/415 (20%), Positives = 196/415 (47%), Gaps = 31/415 (7%)
Query: 45 QQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQK 104
Q+ + ++ R Q+ R E + ER +KE +R QE K W +E++
Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE--KMWEQEEKMQEEER 393
Query: 105 L-EAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSR 163
+ E +KK EE E R+ EE++ KQ + E + +Q +R+ L
Sbjct: 394 IREREKKMREEEETMRE---QEEKMQKQEENMWEQEEKE----WQQQRLPEQKEKLWEQE 446
Query: 164 VMKERDAQIEFRKSKIKSDKK-WEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQI 222
M+E++ +I ++ KI+ ++ W ++ K+ ++ +E++++ ++ + + Q
Sbjct: 447 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 506
Query: 223 KEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMH------ESRRRFLEHM 276
+ E++ER ++ EE+ ++ Q +++ E + + EKK +E E + R E M
Sbjct: 507 ERMWEQDERLREKEER----MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERM 562
Query: 277 QDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSEL 336
+++ E++ E++EKM++ + + + E+E + EK E+ +
Sbjct: 563 REREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622
Query: 337 LKEKL-DNEDMIIARDIAEAEAE---WEKREREKDEKNK-AELKTIAEYRAIVMKNKEEE 391
++K+ + E+M+ ++ E E WE+ E+ ++++ K E + + + M+ +EE+
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEK 682
Query: 392 ERQRKIEAKEQLLAVMKADQIFWEHE-----KEKKCKADKEHQEVQDAHIQQMAK 441
+ ++ + +EQ + ++ W E +E+K +E +E ++ Q K
Sbjct: 683 MQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEK 737
Score = 71.2 bits (173), Expect = 2e-12
Identities = 90/430 (20%), Positives = 187/430 (43%), Gaps = 77/430 (17%)
Query: 92 HWTNTYAGMKEQKLEA----KKKRD---EEIEAERQILDLE---EEIYKQGKRKKAIENA 141
H + +AG ++ L A KK D EE+ ER L LE I + +KK E
Sbjct: 134 HHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ 193
Query: 142 KQYQFYQTER------VKNFHSGL-----LLSRVM----------KERDAQIEFRKSKIK 180
++ + ++E+ VK L LL +V +E + + + +K + +
Sbjct: 194 EKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 253
Query: 181 SDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDA 240
+K W ++ +L ++ EQE+ +R +R+ + L+ E+E+E R++ + ++
Sbjct: 254 EEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELR-----EQEKELREQKKLREQ 308
Query: 241 EEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKF 300
EE ++ E +K+ ++ E+M R E +++Q E+++KMR
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE-----------QEKQMREQEQKMRD- 356
Query: 301 IKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWE 360
+E+ E + ++ ER+ +EK+ + E + + E
Sbjct: 357 ----------QEERMWEQDERLREKEERMRE------QEKMWEQ---------EEKMQEE 391
Query: 361 KREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEK-- 418
+R RE+++K + E +T+ E + K +E Q + E ++Q L K + WE EK
Sbjct: 392 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK--EKLWEQEKMQ 449
Query: 419 EKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREV 478
E++ K ++ ++++D + K ++ + + D E + ++E++ D +
Sbjct: 450 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 509
Query: 479 IELESETTNK 488
E + K
Sbjct: 510 WEQDERLREK 519
Score = 56.6 bits (135), Expect = 6e-08
Identities = 58/272 (21%), Positives = 135/272 (49%), Gaps = 25/272 (9%)
Query: 53 DEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRD 112
D+ +++ D +R+ + ER +KE +R Q+ K W +E+K+ +KK
Sbjct: 497 DQEQKMWDQEERMWEQD-----ERLREKEERMREQK--KMW------QQEEKMREEKKTQ 543
Query: 113 EEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQI 172
E+ E++ D EE++ ++ + ++ + ++ + E+ + R +E+ +
Sbjct: 544 EQ---EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 173 EFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHE-EEEER 231
E K + + +K WE++ EK +++E+E + E + ++ +++ +E E+EE+
Sbjct: 601 E-EKMQEQEEKMWEQE-----EKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK 654
Query: 232 RKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQE 291
++ EEK E+ ++ E +MR++ E+K + E R E M+ + ++++
Sbjct: 655 MREQEEKMREQEEKMQGQEE-KMREQ-EEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMW 712
Query: 292 EEDEKMRKFIKAKKRLIQMGKEKEAETHRLME 323
++EKM + +++ ++ +KE RL E
Sbjct: 713 GQEEKMWGQEEMREKEERIRDQKEKMQERLPE 744
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 89.7 bits (221), Expect = 6e-18
Identities = 102/427 (23%), Positives = 210/427 (49%), Gaps = 43/427 (10%)
Query: 52 HDEWK---RIQDSLDRL-TREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD WK ++ +L + T++ R + KE S E+ ++ T T +KE+ +
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKEKNAKL 214
Query: 108 KKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKE 167
++K + +E+E+ + L K+ KRK +E AK Q + + H G L V +
Sbjct: 215 QEKL-QLVESEKSEIQLN---VKELKRK--LERAKLLLPQQQLQAEADHLGKELQSVSAK 268
Query: 168 RDAQIEF-----RKSKIKSDKKWEEQLKLNI-EKAFKEEQEKA----EKRHRERVALAKD 217
AQ+E R ++ + +K W ++ K+ E+ +E++EK EK R+ + +
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEK 328
Query: 218 HLKQIKEHE---EEEERRKKYEEK--DAEEIKRQNALYEIEMRKKLEKKREEMHESRRRF 272
K ++ E E+EE+ ++ EEK + E+I+ Q + E + + ++KR+E R
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 388
Query: 273 LEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNF 332
E ++++ +++ +E++EKM + + + +E+E + R EK RE+
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 333 LSELLKEKL-DNEDMIIARDIAEAE-----AEWEKREREKDEKNKAELKTIAEYRAIVMK 386
+ +EK+ + E+M+ ++ E E E + +E++EK + + + I E +
Sbjct: 449 REQ--EEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE------Q 500
Query: 387 NKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNA 446
K+ E++ KI +E+++ + ++ WE E EK C+ +++ QE ++ +Q K +
Sbjct: 501 EKKIREQEEKIREQEEMM--QEQEEKMWEQE-EKMCEQEEKMQEQEEKMRRQEEKMREQE 557
Query: 447 KQAKQAE 453
+ +Q E
Sbjct: 558 VRLRQQE 564
Score = 72.8 bits (177), Expect = 8e-13
Identities = 84/412 (20%), Positives = 207/412 (50%), Gaps = 66/412 (16%)
Query: 17 RAKESTEIRNSEEDQV-LYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAE 75
+ +E ++ SE+ ++ L + L K++ ++ ++P + +Q D L +E + A+
Sbjct: 213 KLQEKLQLVESEKSEIQLNVKELKRKLERAKL-LLPQQQ---LQAEADHLGKELQSVSAK 268
Query: 76 RKAKKEMH-----LRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI-EAERQILDLEEEIY 129
+A+ E + L Q+ K W +E+K++ +R+E+I E E +I + EE++
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWR------QEEKIQ---EREEKIQEQEEKIREQEEKMR 319
Query: 130 KQGK----RKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKW 185
+Q + +++ + ++ + + E+++ L M E++ +I ++ K + ++K
Sbjct: 320 RQEEMMWEKEEKMRRQEEMMWEKEEKIRE------LEEKMHEQE-KIREQEEKRQEEEKI 372
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE-EERRKKYEEKDAEEIK 244
EQ K ++EQE R E++ ++ ++I+E EE +E+ +K E++ + +
Sbjct: 373 REQEK-------RQEQEAKMWRQEEKI---REQEEKIREQEEMMQEQEEKMGEQEEKMWE 422
Query: 245 RQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAK 304
++ + E E +K+ ++ E++ E ++ E + + + Q+Q+E+ E+ K + +
Sbjct: 423 QEEEMQEQE--EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQE 480
Query: 305 KRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRER 364
++ +E+E + R EK RE+ + +EK+ ++ ++ + E WE+ E+
Sbjct: 481 AKM----QEQEEKMRRQEEKIREQEKKIREQ--EEKIREQEEMMQE---QEEKMWEQEEK 531
Query: 365 EKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEH 416
+++ K M+ +EE+ R+++ + +EQ + + + ++ EH
Sbjct: 532 MCEQEEK-------------MQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
Score = 70.5 bits (171), Expect = 4e-12
Identities = 86/378 (22%), Positives = 181/378 (47%), Gaps = 47/378 (12%)
Query: 116 EAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDA-QIEF 174
+ E + DL ++ K +E A Q ++ + + + KERDA +E
Sbjct: 143 QLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRY-----IEELTKERDALSLEL 197
Query: 175 RKSKIKSDKKWEEQLKLNIEKAFKEEQEKAE-----KRHRERVALAKDHLKQIKEHEEEE 229
++ I ++ E+ KL EK E EK+E K + ++ AK L Q + E +
Sbjct: 198 YRNTITDEELKEKNAKLQ-EKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 256
Query: 230 ERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
K+ + A K Q + E E+ +L +++EE + ++ ++K +++Q+
Sbjct: 257 HLGKELQSVSA---KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEK-----IQEQE 308
Query: 290 QE--EEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMI 347
++ E++EKMR+ ++ ++ +EK +M ++ E+I L+EK+ ++ I
Sbjct: 309 EKIREQEEKMRR----QEEMMWEKEEKMRRQEEMMWEKEEKIRE-----LEEKMHEQEKI 359
Query: 348 IARDIAEAEAEWEK-REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAV 406
R+ E E EK RE+EK ++ +A++ E ++ +EE+ R+++ +EQ +
Sbjct: 360 --REQEEKRQEEEKIREQEKRQEQEAKMWRQEEK----IREQEEKIREQEEMMQEQEEKM 413
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAE 466
+ ++ WE E+E QE ++ +Q K + K+ ++ E + R E ++ E
Sbjct: 414 GEQEEKMWEQEEEM--------QEQEEKMRRQEEKIREQEKKIREQE-EKIREQEEMMQE 464
Query: 467 KEKEFQDYAREVIELESE 484
+E++ + ++ E E++
Sbjct: 465 QEEKMGEQEGKMCEQEAK 482
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 89.0 bits (219), Expect = 1e-17
Identities = 96/476 (20%), Positives = 227/476 (47%), Gaps = 53/476 (11%)
Query: 17 RAKESTEIRNSEEDQV-LYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAE 75
+ +E ++ SE+ ++ L + L K++ ++ ++P + +Q D L +E + A+
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKL-LLPQQQ---LQAEADHLGKELQSVSAK 280
Query: 76 RKAKKEMH-----LRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI--EAERQILDLEEEI 128
+A+ E + L Q+ K W K Q+ E K + EE E E +I + EE++
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEE---KIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 129 YKQGK----RKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKK 184
+Q + +++ + ++ + + E+++ L +M E++ +I + K+ +K
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRR------LEEMMWEKEEKIRELEEKMHEQEK 391
Query: 185 WEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIK 244
EQ EE+ + E++ RE+ + K ++ E+ E+ +K E++ + +
Sbjct: 392 IREQ----------EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR 441
Query: 245 RQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAK 304
++ ++E E ++ E+KR+E E R+ + + + I + E+ ++E+ K + + +
Sbjct: 442 QEEKIHEQEKIRE-EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ 500
Query: 305 KRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRER 364
+ + +EK E M ++ E+I +EK+ ++ I R+ E E E++
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIRE-----QEEKIREQEEKI-REQEEMMQEQEEKMG 554
Query: 365 EKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKA 424
E++EK + + K M+ +EE+ R+++ + +EQ + + ++ W E+E+K +
Sbjct: 555 EQEEKMQEQEK---------MRRQEEKIREQEEKIREQKEKIREQEEKIW--EQEEKIRE 603
Query: 425 DKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIE 480
+E + Q+ + + + ++ Q + + R E + E+E + ++ E
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 84.7 bits (208), Expect = 2e-16
Identities = 97/412 (23%), Positives = 194/412 (47%), Gaps = 83/412 (20%)
Query: 54 EWK-RIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKL----EAK 108
EW+ +IQ+ +++ + +R ++E +R QE + W +++++ E K
Sbjct: 311 EWEEKIQEQEEKIREQEEKIR-----EQEEKMRRQEEMM-WEKEEKMRRQEEMMWEKEEK 364
Query: 109 KKRDEEI--EAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK 166
+R EE+ E E +I +LEE++++Q K ++ E ++ + + + + + + K
Sbjct: 365 MRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 424
Query: 167 ERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEK----RHRERVALAKDHLKQI 222
R+ + + R+ + K W ++ K++ ++ +EE+++ E+ R E++ ++ +Q
Sbjct: 425 IREQEEKIREQE---KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ- 480
Query: 223 KEHEEEEERRKKYEEK---------DAEEIKRQNA----LYEIEMRKKLEKKREEMHESR 269
KE E+E+ +K EEK D EE R+ E ++R++ EK RE+ E +
Sbjct: 481 KEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ--EEK 538
Query: 270 RRFLEHMQDKHIIKAVEQQQQEEEDEKMRK---FIKAKKRLIQMGKEKEAETHRLMEKRR 326
R E M + K EQ+++ +E EKMR+ I+ ++ I+ KEK E + ++
Sbjct: 539 IREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQE 598
Query: 327 ERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMK 386
E+I E+++E + E WE+ E+ +++ K +
Sbjct: 599 EKIRE-QEEMMQE--------------QEEKMWEQEEKMCEQEEKMQ------------- 630
Query: 387 NKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADK--EHQEVQDAHI 436
E+EE+ R+ E K WE E + + +K EHQE +A I
Sbjct: 631 --EQEEKMRRQEEK------------MWEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 81.3 bits (199), Expect = 2e-15
Identities = 100/454 (22%), Positives = 207/454 (45%), Gaps = 49/454 (10%)
Query: 52 HDEWK---RIQDSLDRL-TREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD WK ++ +L + T++ R + KE S E+ ++ T T +KE+ +
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKEKNAKL 226
Query: 108 KKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKE 167
++K + +E+E+ + L K+ KRK +E AK Q + + H G L V +
Sbjct: 227 QEKL-QLVESEKSEIQLN---VKELKRK--LERAKLLLPQQQLQAEADHLGKELQSVSAK 280
Query: 168 RDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQ--EKAEKRHRERVALAKDHLKQIKEH 225
AQ+E ++ W + EK +++E+ ++ E++ +E+ ++ ++I+E
Sbjct: 281 LQAQVE-------ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 226 EEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAV 285
EE+ R+++ + E+++RQ E+ E E RR E M +K K
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQ------------EEMMWEKEEKMRRLEEMMWEKEE-KIR 380
Query: 286 EQQQQEEEDEKMR-----KFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEK 340
E +++ E EK+R + + K R + +E+EA+ R EK RE+ + K
Sbjct: 381 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440
Query: 341 LDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAK 400
E + I E E E+ E + E+ E + I + + + ++ +++ K+ +
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ 500
Query: 401 EQLL-----AVMKADQIFWE-----HEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK 450
E+ + + + ++ W E+E+K + +E Q+ +Q+ + K ++ K
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ-EEKMGEQEEK 559
Query: 451 QAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
E + R E + E+E++ ++ ++ E E +
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 87.0 bits (214), Expect = 4e-17
Identities = 97/427 (22%), Positives = 200/427 (46%), Gaps = 61/427 (14%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQIL---DLEEEIYKQGKRK 135
++ MH +E +K K + LEA++++ ++ E Q L +LEE ++
Sbjct: 61 QRSMHAYQREKMKE-------EKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQE 113
Query: 136 KAI-ENAKQYQFYQTERVKNFHSGLLLSRVMKE----RDAQIEFRKSKI-------KSDK 183
+ I E + + + E+ K LL K R+ +++ + + K +K
Sbjct: 114 RRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEK 173
Query: 184 KWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEI 243
K +E K ++ E E+A + ER+ A++ +Q+++ + E ++ EE +E+
Sbjct: 174 KQQEATAEQENKRYENEYERARREALERMK-AEEERRQLEDKLQAEALLQQMEELKLKEV 232
Query: 244 K-------RQNALYEIEMRKKLEKKREEMHESRR-----RFLEHMQDKHIIKAVEQQQQE 291
+ ++N L + ++LE++R++M R+ RFL H + + + +Q Q+E
Sbjct: 233 EATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE 292
Query: 292 EEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIH---NFLSELLKEKL------D 342
++A +R++Q EKE E+ RL RRE++ ++ + ++E+L +
Sbjct: 293 ---------LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
Query: 343 NEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEY---RAIVMKNKEEEERQRKIEA 399
E ++ R+ EA+ WEKRE E + A + ++E R ++ K E+ R+ + E+
Sbjct: 344 AELQMLLRE--EAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
Query: 400 ---KEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDY 456
+EQL+ ++ + EKE+ K ++ +A + + + A Q ++ E +
Sbjct: 402 LKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
Query: 457 CRLTEAL 463
R E L
Sbjct: 462 ARRVEQL 468
Score = 60.5 bits (145), Expect = 4e-09
Identities = 79/304 (25%), Positives = 143/304 (47%), Gaps = 49/304 (16%)
Query: 53 DEWKRIQ-DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKR 111
+E++R + ++L+R+ E + E K + E L+ E +K +KE + KK
Sbjct: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELK--------LKEVEATKLKKE 240
Query: 112 DEEIEAERQILDLEEEIYKQGK--RKKAIENA---KQYQFYQTERVKNFHSGL-----LL 161
E + +R L+ EE KQ + R+KA QY + R + L +L
Sbjct: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
Query: 162 SRVMKERDAQIEF---RKSKIKSDKKW-----EEQLKLN------IEKAFKEE-QEKAEK 206
++++ D R+ ++ +D W EEQL+L ++ +EE +E EK
Sbjct: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360
Query: 207 RHRE--RVALAKDHL---------KQIKEHEEEEERRKKYEEKDAEEIKRQNALYEI-EM 254
R E R A+D L +QI+E E+ R ++ K E++ R L E+ E+
Sbjct: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRN--LEEVREL 418
Query: 255 RKKLEKKREEMHESRRRFLEHMQDKHIIKAVE-QQQQEEEDEKMRKFIKAKKRLIQMGKE 313
++ +++ E++ +R++ LE + ++A E QQ+EEE+E+ R+ + L+Q E
Sbjct: 419 ARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
Query: 314 KEAE 317
AE
Sbjct: 479 TMAE 482
Score = 58.5 bits (140), Expect = 2e-08
Identities = 66/327 (20%), Positives = 154/327 (47%), Gaps = 35/327 (10%)
Query: 75 ERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDE------EIEAERQILDLEEEI 128
+++ KK+ +++ K + N Y + + LE K +E +++AE + +EE
Sbjct: 169 QKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELK 228
Query: 129 YKQ---GKRKKAIENAKQYQFYQTERVKN-------FHSGLLLSRVMKER-DAQIEFRKS 177
K+ K KK EN + Q ++ ER++ F L R ++ + +AQ+ R
Sbjct: 229 LKEVEATKLKKEQENLLK-QRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQ 287
Query: 178 KIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEE 237
+I+ + + + + I +A E+++++++ H R + +K+ EE+ + ++ E
Sbjct: 288 QIQEELEADRR----ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
Query: 238 KDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHM---QDKHIIKAVEQQQ--QEE 292
+ + + R+ A EM +K E + +R R + + + + I + +EQ + QEE
Sbjct: 344 AELQMLLREEAK---EMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEE 400
Query: 293 EDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDI 352
+ + I+ + + ++ + ++ E+ +L R++ + ++E + + + +
Sbjct: 401 SLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEAD-----QQE 455
Query: 353 AEAEAEWEKREREKDEKNKAELKTIAE 379
E E E + E+ D + E +T+AE
Sbjct: 456 EEEEEEARRVEQLSDALLQQEAETMAE 482
Score = 45.1 bits (105), Expect = 2e-04
Identities = 66/305 (21%), Positives = 136/305 (44%), Gaps = 41/305 (13%)
Query: 204 AEKRHRERVALAKDHLKQIKEHEEEEERRKKYEE----KDAE---EIKRQNALYEIEMRK 256
+++R +++A ++ ++++ E+ R + + K AE + Q +++ + K
Sbjct: 12 SQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
Query: 257 KLEKKREEMHESRRRFLEHMQDKHIIKAVE----------QQQQEEEDEKMRKFIKAKKR 306
E+KR + R + + MQ++ + A E Q+++ E K K ++R
Sbjct: 72 MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
Query: 307 ------LIQMGKEKEAETHRLMEKRRERIHNFLS-ELLKEKLDNEDMIIARDIAEAEAEW 359
L+ +K R ME + H S E+ KE+ ++ ++ E E+
Sbjct: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
Query: 360 EKREREKDEKNKAE---LKTIAEYRAIVMKNKEEEERQRKIEA----KEQLLAVMKADQI 412
E+ RE E+ KAE + + +A + + EE + +++EA KEQ + + ++
Sbjct: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251
Query: 413 FWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAK-----QAKQAELDYCRLTEALVAEK 467
E+ K+ +A + Q A + + ++++NA+ Q Q EL+ R + EK
Sbjct: 252 ERLEEERKQMEAFR-----QKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEK 306
Query: 468 EKEFQ 472
E E Q
Sbjct: 307 EDESQ 311
Score = 42.4 bits (98), Expect = 0.001
Identities = 62/294 (21%), Positives = 128/294 (43%), Gaps = 54/294 (18%)
Query: 19 KESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDE-----WKRIQDSLDRLTREAACLR 73
+E+ E +EE++ L ++ LQQ+ + E K+ Q++L + E L
Sbjct: 196 REALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLE 255
Query: 74 AERKAKKEMHLRSQ--EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILD--LEEEIY 129
ERK + +++ ++H N + Q+++ EE+EA+R+IL LE+E
Sbjct: 256 EERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQ------EELEADRRILQALLEKEDE 309
Query: 130 KQ----GKRKKAIENA---KQY--QFYQTERVKNFHSGLLLSRVMKE--RDAQIEFRKSK 178
Q +R++ + + KQ + Q ER + +LL KE + E+ + +
Sbjct: 310 SQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARER 369
Query: 179 IKSDKKWEEQL---KLNIEKAFKEEQEKAEK--RHRERVALAKDHLKQIKEHEEEEERRK 233
D+ E L + I++ ++ + E+ +HRE++ + ++++ E+EE +
Sbjct: 370 SARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKL 429
Query: 234 K-----------------------YEEKDAEEIKRQNALYEIEMRKKLEKKREE 264
K EE++ EE +R L + ++++ E E+
Sbjct: 430 KSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 87.0 bits (214), Expect = 4e-17
Identities = 97/427 (22%), Positives = 200/427 (46%), Gaps = 61/427 (14%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQIL---DLEEEIYKQGKRK 135
++ MH +E +K K + LEA++++ ++ E Q L +LEE ++
Sbjct: 61 QRSMHAYQREKMKE-------EKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQE 113
Query: 136 KAI-ENAKQYQFYQTERVKNFHSGLLLSRVMKE----RDAQIEFRKSKI-------KSDK 183
+ I E + + + E+ K LL K R+ +++ + + K +K
Sbjct: 114 RRIREQHGKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEK 173
Query: 184 KWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEI 243
K +E K ++ E E+A + ER+ A++ +Q+++ + E ++ EE +E+
Sbjct: 174 KQQEATAEQENKRYENEYERARREALERMK-AEEERRQLEDKLQAEALLQQMEELKLKEV 232
Query: 244 K-------RQNALYEIEMRKKLEKKREEMHESRR-----RFLEHMQDKHIIKAVEQQQQE 291
+ ++N L + ++LE++R++M R+ RFL H + + + +Q Q+E
Sbjct: 233 EATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE 292
Query: 292 EEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIH---NFLSELLKEKL------D 342
++A +R++Q EKE E+ RL RRE++ ++ + ++E+L +
Sbjct: 293 ---------LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
Query: 343 NEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEY---RAIVMKNKEEEERQRKIEA 399
E ++ R+ EA+ WEKRE E + A + ++E R ++ K E+ R+ + E+
Sbjct: 344 AELQMLLRE--EAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEES 401
Query: 400 ---KEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDY 456
+EQL+ ++ + EKE+ K ++ +A + + + A Q ++ E +
Sbjct: 402 LKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEE 461
Query: 457 CRLTEAL 463
R E L
Sbjct: 462 ARRVEQL 468
Score = 60.5 bits (145), Expect = 4e-09
Identities = 79/304 (25%), Positives = 143/304 (47%), Gaps = 49/304 (16%)
Query: 53 DEWKRIQ-DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKR 111
+E++R + ++L+R+ E + E K + E L+ E +K +KE + KK
Sbjct: 189 NEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELK--------LKEVEATKLKKE 240
Query: 112 DEEIEAERQILDLEEEIYKQGK--RKKAIENA---KQYQFYQTERVKNFHSGL-----LL 161
E + +R L+ EE KQ + R+KA QY + R + L +L
Sbjct: 241 QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL 300
Query: 162 SRVMKERDAQIEF---RKSKIKSDKKW-----EEQLKLN------IEKAFKEE-QEKAEK 206
++++ D R+ ++ +D W EEQL+L ++ +EE +E EK
Sbjct: 301 QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK 360
Query: 207 RHRE--RVALAKDHL---------KQIKEHEEEEERRKKYEEKDAEEIKRQNALYEI-EM 254
R E R A+D L +QI+E E+ R ++ K E++ R L E+ E+
Sbjct: 361 REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRN--LEEVREL 418
Query: 255 RKKLEKKREEMHESRRRFLEHMQDKHIIKAVE-QQQQEEEDEKMRKFIKAKKRLIQMGKE 313
++ +++ E++ +R++ LE + ++A E QQ+EEE+E+ R+ + L+Q E
Sbjct: 419 ARREKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAE 478
Query: 314 KEAE 317
AE
Sbjct: 479 TMAE 482
Score = 58.5 bits (140), Expect = 2e-08
Identities = 66/327 (20%), Positives = 154/327 (47%), Gaps = 35/327 (10%)
Query: 75 ERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDE------EIEAERQILDLEEEI 128
+++ KK+ +++ K + N Y + + LE K +E +++AE + +EE
Sbjct: 169 QKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELK 228
Query: 129 YKQ---GKRKKAIENAKQYQFYQTERVKN-------FHSGLLLSRVMKER-DAQIEFRKS 177
K+ K KK EN + Q ++ ER++ F L R ++ + +AQ+ R
Sbjct: 229 LKEVEATKLKKEQENLLK-QRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQ 287
Query: 178 KIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEE 237
+I+ + + + + I +A E+++++++ H R + +K+ EE+ + ++ E
Sbjct: 288 QIQEELEADRR----ILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERARE 343
Query: 238 KDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHM---QDKHIIKAVEQQQ--QEE 292
+ + + R+ A EM +K E + +R R + + + + I + +EQ + QEE
Sbjct: 344 AELQMLLREEAK---EMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEE 400
Query: 293 EDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDI 352
+ + I+ + + ++ + ++ E+ +L R++ + ++E + + + +
Sbjct: 401 SLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEAD-----QQE 455
Query: 353 AEAEAEWEKREREKDEKNKAELKTIAE 379
E E E + E+ D + E +T+AE
Sbjct: 456 EEEEEEARRVEQLSDALLQQEAETMAE 482
Score = 45.1 bits (105), Expect = 2e-04
Identities = 66/305 (21%), Positives = 136/305 (44%), Gaps = 41/305 (13%)
Query: 204 AEKRHRERVALAKDHLKQIKEHEEEEERRKKYEE----KDAE---EIKRQNALYEIEMRK 256
+++R +++A ++ ++++ E+ R + + K AE + Q +++ + K
Sbjct: 12 SQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREK 71
Query: 257 KLEKKREEMHESRRRFLEHMQDKHIIKAVE----------QQQQEEEDEKMRKFIKAKKR 306
E+KR + R + + MQ++ + A E Q+++ E K K ++R
Sbjct: 72 MKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQR 131
Query: 307 ------LIQMGKEKEAETHRLMEKRRERIHNFLS-ELLKEKLDNEDMIIARDIAEAEAEW 359
L+ +K R ME + H S E+ KE+ ++ ++ E E+
Sbjct: 132 KLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEY 191
Query: 360 EKREREKDEKNKAE---LKTIAEYRAIVMKNKEEEERQRKIEA----KEQLLAVMKADQI 412
E+ RE E+ KAE + + +A + + EE + +++EA KEQ + + ++
Sbjct: 192 ERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWEL 251
Query: 413 FWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAK-----QAKQAELDYCRLTEALVAEK 467
E+ K+ +A + Q A + + ++++NA+ Q Q EL+ R + EK
Sbjct: 252 ERLEEERKQMEAFR-----QKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEK 306
Query: 468 EKEFQ 472
E E Q
Sbjct: 307 EDESQ 311
Score = 42.4 bits (98), Expect = 0.001
Identities = 62/294 (21%), Positives = 128/294 (43%), Gaps = 54/294 (18%)
Query: 19 KESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDE-----WKRIQDSLDRLTREAACLR 73
+E+ E +EE++ L ++ LQQ+ + E K+ Q++L + E L
Sbjct: 196 REALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELERLE 255
Query: 74 AERKAKKEMHLRSQ--EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILD--LEEEIY 129
ERK + +++ ++H N + Q+++ EE+EA+R+IL LE+E
Sbjct: 256 EERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQ------EELEADRRILQALLEKEDE 309
Query: 130 KQ----GKRKKAIENA---KQY--QFYQTERVKNFHSGLLLSRVMKE--RDAQIEFRKSK 178
Q +R++ + + KQ + Q ER + +LL KE + E+ + +
Sbjct: 310 SQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARER 369
Query: 179 IKSDKKWEEQL---KLNIEKAFKEEQEKAEK--RHRERVALAKDHLKQIKEHEEEEERRK 233
D+ E L + I++ ++ + E+ +HRE++ + ++++ E+EE +
Sbjct: 370 SARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKL 429
Query: 234 K-----------------------YEEKDAEEIKRQNALYEIEMRKKLEKKREE 264
K EE++ EE +R L + ++++ E E+
Sbjct: 430 KSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQ 483
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 85.9 bits (211), Expect = 9e-17
Identities = 92/469 (19%), Positives = 220/469 (46%), Gaps = 61/469 (13%)
Query: 37 LLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNT 96
++P++ + II +E++RI+ + LTRE E+ R Q K T
Sbjct: 91 IVPTEDPSGESLIISPEEFERIKWASHVLTRE------------ELEARDQAFKKEKEAT 138
Query: 97 YAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFH 156
+ +K + K+++ +++ DLEE + + + ++ A + + Q E +K+
Sbjct: 139 MDAVMTRK-KIMKQKEMVWNNNKKLSDLEE--VAKERAQNLLQRANKLRMEQEEELKDMS 195
Query: 157 SGLLLSRVMKERDAQI----EFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERV 212
+L ++ RDAQI + +K +K+ ++ +++ +K+ + ++E KR ER+
Sbjct: 196 KIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERI 255
Query: 213 ALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRF 272
+ ++Q+++++EE + E++ E++ +E ++L++ E++ + RR
Sbjct: 256 RGRRQIVEQMEKNQEERSLLAEQREQEKEQM--------LEYMEQLQE--EDLKDMERRQ 305
Query: 273 LEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-------EAETHRLMEKR 325
+ ++ + IK + + Q+++ E + + A + +++ K+K EAE R+ ++
Sbjct: 306 QQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKKMAREAEFEAEQERIRREK 365
Query: 326 RERIHNF--LSELLKEKLDNEDMIIARDIAE-AEAEWEKREREKDEK--------NKAEL 374
+ I + E ++ +D + A+ E A+ EW ++E+E K K+ L
Sbjct: 366 EKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRRKEKENARKKMETEAELRKSRL 425
Query: 375 KTIA--EYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEH-QEV 431
+ +A E+ V ++ +E +R + A+ + + + E+EKK +H E+
Sbjct: 426 EQVAFKEHALAVQVQRDRDEFERILRAQREQIEKERL-------EEEKKATGRLQHANEL 478
Query: 432 QDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIE 480
+ +Q+ +N+ Q + A + R + ++ + + R+ +E
Sbjct: 479 R----RQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKRKKLE 523
Score = 38.9 bits (89), Expect = 0.012
Identities = 58/253 (22%), Positives = 115/253 (45%), Gaps = 34/253 (13%)
Query: 23 EIRNSEEDQVLYLPLLPSKVDL------QQVTIIPHDEWKRIQDSLDRLTREAACLRAER 76
E R E++Q+L + DL QQ + E KRI D + ++A L E+
Sbjct: 277 EQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQK--QKAELLAQEK 334
Query: 77 KA--------KKEMHLRSQEVVKHWTNTYAGMKE-QKLEAKKKRDEEIEAERQILDLE-- 125
A KK+M ++ + KE +L A +++ ++ +AE+ L +
Sbjct: 335 LADQMVMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRN 394
Query: 126 EEIYKQGKRKKAIENAKQYQFYQTERVKN------FHSGLLLSRVMKERD-------AQI 172
+E+ + R+K ENA++ + E K+ F L +V ++RD AQ
Sbjct: 395 QEVADREWRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDRDEFERILRAQR 454
Query: 173 E-FRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEER 231
E K +++ +KK +L+ + + ++ +E +K + R+A ++ + +E ++ ER
Sbjct: 455 EQIEKERLEEEKKATGRLQ-HANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRER 513
Query: 232 RKKYEEKDAEEIK 244
+ + K EE++
Sbjct: 514 IDEIKRKKLEELR 526
Score = 37.0 bits (84), Expect = 0.047
Identities = 49/194 (25%), Positives = 80/194 (41%), Gaps = 20/194 (10%)
Query: 20 ESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEW--KRIQDSLDRLTREAACLRAERK 77
E IR +E ++ L + K Q D KR Q+ DR R A +K
Sbjct: 357 EQERIRREKEKEIARLRAMQEKAQDYQAE---QDALRAKRNQEVADREWRRKEKENARKK 413
Query: 78 AKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEE-----IEAERQILD---LEEEIY 129
+ E LR + + KE L + +RD + + A+R+ ++ LEEE
Sbjct: 414 METEAELRKSRLEQ------VAFKEHALAVQVQRDRDEFERILRAQREQIEKERLEEEKK 467
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
G+ + A E +Q + Q + V+N + R +KE + R +IK KK EE
Sbjct: 468 ATGRLQHANELRRQVRENQQKEVQNRIATFEEGRRLKEEAQKRRERIDEIKR-KKLEELR 526
Query: 190 KLNIEKAFKEEQEK 203
+ + + E E+
Sbjct: 527 ATGLPEKYCIEAER 540
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 84.3 bits (207), Expect = 3e-16
Identities = 90/404 (22%), Positives = 180/404 (44%), Gaps = 43/404 (10%)
Query: 64 RLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER-QIL 122
R T + ER+ +K+ H + +H KE++ + ++RD + E ER +
Sbjct: 69 RQTERETDRKRERRREKDRHRKRD---RHRERQRDREKERERQTDRERDRQREKERNRQK 125
Query: 123 DLEEEIYKQGKR-----------KKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQ 171
+ E E ++G+R ++ +A++ + QT+R + + ER+ Q
Sbjct: 126 ERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQT---------ERNRQ 176
Query: 172 IEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEER 231
E + K + +++ E+ + K E+ +R RER + K+ + E + +R
Sbjct: 177 KEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQR 236
Query: 232 RKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVE---- 286
+ + E EK AE + E + ++ E+ R+ + R++ E D+ + E
Sbjct: 237 KTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRE 296
Query: 287 -----QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKL 341
++Q+E E E+ R + ++R + +E++ ET R EK RER +E+ +E+
Sbjct: 297 TERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRER- 355
Query: 342 DNEDMIIARDIAEAEAEWEK-------REREKDEKNKAELKTIAEYRAIVMKNKEEEERQ 394
+ + R AE E E E+ RERE+ E+++ + E K+++ +
Sbjct: 356 NRQTGREGRRQAERERERERERDRQSAREREERERDR-DRDRQKERERQTEKDRDGQRET 414
Query: 395 RKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQ 438
K +E+ + + E EK+K + D+E Q + A Q+
Sbjct: 415 EKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQR 458
Score = 77.8 bits (190), Expect = 2e-14
Identities = 68/303 (22%), Positives = 143/303 (47%), Gaps = 23/303 (7%)
Query: 166 KERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEH 225
KER+ + E R+++ ++D+K E + + + + K ++ + +R RE+ + ++ ++
Sbjct: 60 KERERRREKRQTERETDRKRERRREKDRHR--KRDRHRERQRDREKERERQTDRERDRQR 117
Query: 226 EEEEERRKKYEEKDAEEIKR-----QNALYEIEMRKKLEKKRE-EMHESRRRFLEHMQDK 279
E+E R+K+ E + E +R + E E ++ EK+RE + R+R E + K
Sbjct: 118 EKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQK 177
Query: 280 HIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK------EAETHRLMEKRRERIHNFL 333
+ +Q++ E + + K K + R + G+E+ E ET R + RER
Sbjct: 178 EREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRK 237
Query: 334 SELLKEKLDNEDMIIARDIAEAEAEWEK-REREKDEKNKAELKTIAEYRAIVMKNKEEEE 392
+E +EK + +E E E +K RERE+D + + R K + E
Sbjct: 238 TEREREKQAERER-----ASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 393 RQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQA 452
R R+ E K + + ++ E ++++ + ++E + + ++ + + K+ +Q
Sbjct: 293 RDRETERKRERQRERERER---ERNRKRERERERERERERQRETERDREKERERKRKRQT 349
Query: 453 ELD 455
E+D
Sbjct: 350 EMD 352
Score = 69.7 bits (169), Expect = 7e-12
Identities = 68/331 (20%), Positives = 151/331 (45%), Gaps = 25/331 (7%)
Query: 161 LSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLK 220
L + K+ D + +++ K ++ E+ + E K E+ + + RHR+R D +
Sbjct: 42 LGQAHKDADGD-DRERNRQKERERRREKRQTERETDRKRERRREKDRHRKR-----DRHR 95
Query: 221 QIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKH 280
+ + E+E R+ E+D + K +N E E + E +R R R + +++
Sbjct: 96 ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGER-----GRDRQTDGQRER- 149
Query: 281 IIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEK 340
++Q++ E E+ R+ + ++R + ++KE E + ++RRER E E
Sbjct: 150 ------ERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTED 203
Query: 341 LDNEDMIIARDIAEAEAEWEKR---EREKDEKNKAEL---KTIAEYRAIVMKNKEEEERQ 394
+E E E E E++ +RE+D + K E K RA + + ++ER+
Sbjct: 204 RHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERE 263
Query: 395 RKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAEL 454
R+ + K + + +++++ + D+E + ++ ++ + + N K+ ++ E
Sbjct: 264 RERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERER 323
Query: 455 DYCRLTE-ALVAEKEKEFQDYAREVIELESE 484
+ R + ++EKE + + E++ E
Sbjct: 324 ERERERQRETERDREKERERKRKRQTEMDRE 354
Score = 63.5 bits (153), Expect = 5e-10
Identities = 74/316 (23%), Positives = 139/316 (43%), Gaps = 47/316 (14%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R ER+ ++E ++++ +E + E ++KR + E +RQ E E KQ
Sbjct: 188 RRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQ-RKTEREREKQA 246
Query: 133 KRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLN 192
+R++A E + ER + R KER+ Q + RK + ++++ E + K
Sbjct: 247 ERERASERETERD---KERERERDRDRDRDRRQKERERQTD-RKRQRRTERDRETERKRE 302
Query: 193 IEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEI 252
++ + E+E+ KR RER E E E ER+++ E+D E+ + + +
Sbjct: 303 RQRERERERERNRKRERER------------ERERERERQRE-TERDREKERERKRKRQT 349
Query: 253 EMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEED--------EKMRKFIKAK 304
EM + E+ R+ E RR+ E++++ E D E+ R + +
Sbjct: 350 EMDR--ERNRQTGREGRRQAER-----------ERERERERDRQSAREREERERDRDRDR 396
Query: 305 KRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRER 364
++ + EK+ + R EK+RER + SE +E+ R+ + + RER
Sbjct: 397 QKERERQTEKDRDGQRETEKQREREKDRESERGRER--------GREREKQKGRERDRER 448
Query: 365 EKDEKNKAELKTIAEY 380
+ D + + K Y
Sbjct: 449 QTDRQAGRQRKRSTLY 464
Score = 61.2 bits (147), Expect = 2e-09
Identities = 69/307 (22%), Positives = 137/307 (44%), Gaps = 31/307 (10%)
Query: 189 LKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNA 248
+++ I F + +++ R R L + H K+ + ++ R + +E++ KRQ
Sbjct: 18 VEVTIPLDFSRRRPGSQESPRRR-GLGQAH----KDADGDDRERNRQKERERRREKRQT- 71
Query: 249 LYEIEMRKKLEKKRE-EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRL 307
E E +K E++RE + H R R E +D+ K E+Q E D + + K+R
Sbjct: 72 --ERETDRKRERRREKDRHRKRDRHRERQRDRE--KERERQTDRERDRQ-----REKERN 122
Query: 308 IQMGKEKEAETHRLMEKRRERIHNFLSE------LLKEKLDNEDMIIARDIAEAEAEWEK 361
Q KE+E ET R E+ R+R + E KE+ D R + +
Sbjct: 123 RQ--KERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERE 180
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
RE+ + E+ + E + E + ++ ER+R+ E + + + D+ E ++++K
Sbjct: 181 REKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR---ERDRQRK 237
Query: 422 CKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
+ ++E Q A ++ ++ + + ++ E D R + E+E++ + E
Sbjct: 238 TEREREKQ----AERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTER 293
Query: 482 ESETTNK 488
+ ET K
Sbjct: 294 DRETERK 300
Score = 45.8 bits (107), Expect = 1e-04
Identities = 54/257 (21%), Positives = 109/257 (42%), Gaps = 29/257 (11%)
Query: 43 DLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKE 102
D Q+ T ++ + + +R T ER ++ R +E + E
Sbjct: 233 DRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 103 QKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLS 162
+ E ++KR+ + E ER E E ++ +R++ E ++ Q +TER +
Sbjct: 293 RDRETERKRERQRERER-----ERERNRKRERERERERERERQ-RETERDRE-------- 338
Query: 163 RVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQI 222
KER+ RK K +++ E + E + E+E+ +R R+R + +
Sbjct: 339 ---KERE-----RKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARE------ 384
Query: 223 KEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHII 282
+E E + R + +E++ + K ++ E E +++ EK RE R R E + K
Sbjct: 385 REERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRES-ERGRERGREREKQKGRE 443
Query: 283 KAVEQQQQEEEDEKMRK 299
+ E+Q + + ++
Sbjct: 444 RDRERQTDRQAGRQRKR 460
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 84.3 bits (207), Expect = 3e-16
Identities = 111/527 (21%), Positives = 230/527 (43%), Gaps = 81/527 (15%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAER 76
+ K ++ EE+ L + QQ +E K ++ +LT E L+ +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKA---ENELKELEQKHSQLTEEKNLLQEQL 896
Query: 77 KAKKEMHLRSQEV------VKHWTNTYAGMKEQKLEAKKKRDEEIEAER-----QILDLE 125
+A+ E++ ++E+ K E +LE ++ R ++++AER Q+LDLE
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 126 EEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKW 185
E++ ++ ++ ++ K ++K +L+ ++ + +K+ ++K
Sbjct: 957 EQLEEEEAARQKLQLEK---VTAEAKIKKLEDEILV----------MDDQNNKLSKERKL 1003
Query: 186 EEQLKLNIEKAFKEEQEKA------EKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD 239
E+ ++ EE+EKA + +H ++ + LK+ ++ +E E+ K+ E D
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 240 AEEIKRQNALYE---IEMRKKLEKKREEMHESRRRFLEHM-QDKHIIKAVEQQQ------ 289
A + Q A + E++ +L KK EE+ + R + + Q + +K + + +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEA------------ETHRLMEKRRERIHNFLSELL 337
QE+ D + KA+K+ +G+E EA T + + +RE+ L + L
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 338 KEKLDNEDMII-------ARDIAEAEAEWE--KREREKDEKNKAELK-----TIAEYRAI 383
E+ + + + A+ + E + E KR + +KNK L+ E R +
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 384 VMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNK 443
+E E +++K+EA+ Q L +D E+ + DK H+ + N+
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSD-----GERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 444 FNAKQAKQAELDYCRL------TEALVAEKEKEFQDYAREVIELESE 484
K K A+ D L T+ L+ E+ ++ + + ++ +LE E
Sbjct: 1299 AEGKAIKLAK-DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
Score = 65.5 bits (158), Expect = 1e-10
Identities = 92/430 (21%), Positives = 188/430 (43%), Gaps = 65/430 (15%)
Query: 78 AKKEMHLRSQEVVKHWTNTYAGM----------KEQKLEAKKKRDEEIEAERQILDLEEE 127
AK++ L + +V++ Y + K + L +++EE++A+ E+E
Sbjct: 807 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAK------EDE 860
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERD--AQIEFRKSKIKSDKKW 185
+ K +R++ EN + + Q LL ++ E + A+ E + ++ + K+
Sbjct: 861 LQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 919
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYE-EKDAEEIK 244
E++ +E +EE+++ ++ ER +A+ L ++ EEEE R+K + EK E K
Sbjct: 920 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979
Query: 245 RQNALYEI----EMRKKLEKKREEM-------------HESRRRFLEHMQDKHIIKAVEQ 287
+ EI + KL K+R+ + E + + L +++KH E
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 288 QQQEEEDEKMRKFIKAKKRLIQMG-----------KEKEAETHRLMEKRRERIHNFLSEL 336
+ + +++EK R+ ++ KR ++ + + AE + K+ E + L+ L
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 337 LKEKLDNEDMIIARDIAEAEA---------EWEKREREKDEKNKAEL-KTIAEYRAIVMK 386
E + + + I E E + E+ R K EK K +L + + + +
Sbjct: 1100 DDEIAQKNNAL--KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 387 NKEEEERQRKIEAK-EQLLAVMK--ADQIFWEHEKEKKCKADKEHQEVQD--AHIQQMAK 441
+ Q+++ AK EQ + V+K D+ HE + + K Q V++ ++Q +
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 442 NKFNAKQAKQ 451
K N + KQ
Sbjct: 1218 AKANLDKNKQ 1227
Score = 60.8 bits (146), Expect = 3e-09
Identities = 102/490 (20%), Positives = 207/490 (42%), Gaps = 51/490 (10%)
Query: 2 DTSSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDS 61
+T + L R AKE E R ++ + L+ SK D+ + + ++
Sbjct: 1482 ETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 62 LDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI--EAER 119
++ + + L E +A ++ LR + ++ G E+ L+A+ +++EE + +R
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQ----ALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKI 179
Q+ + E E+ + K++ AK+ +++ L L + D+ I+ R+ I
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKK-------KLEGDLKDLEL-----QADSAIKGREEAI 1644
Query: 180 KSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD 239
K +K + Q+K F+ E E A E A AK E E++ K E D
Sbjct: 1645 KQLRKLQAQMK-----DFQRELEDARASRDEIFATAK-----------ENEKKAKSLEAD 1688
Query: 240 AEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEH----MQDKHIIKAVEQQQQEEEDE 295
+++ A E RK+ + ++EE+ E L +K ++A Q +EE +E
Sbjct: 1689 LMQLQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 296 KMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEA 355
+ R+ + ++ E ++ L +R N E +++L+ ++ E
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN---ESARQQLERQNK-------EL 1797
Query: 356 EAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWE 415
++ + E K K+ + + A + + E+E R+++ K K +I +
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 416 HEKEKK-CKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDY 474
E E+K + KE E +A ++Q+ + A++ Q R + + E + +
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 475 AREVIELESE 484
REV L+S+
Sbjct: 1918 GREVNALKSK 1927
Score = 59.3 bits (142), Expect = 9e-09
Identities = 98/479 (20%), Positives = 203/479 (42%), Gaps = 72/479 (15%)
Query: 56 KRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI 115
K+++ + L ++ C ER A+ E++ + ++ + + E + +A K +
Sbjct: 1255 KKLEAQVQEL--QSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 116 EAERQILDLEEEIYKQGKRK-----KAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDA 170
Q+ D +E + ++ ++K K + ++ Q + + + L R + +
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371
Query: 171 QIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEE- 229
Q+ K K++ E L+ +K F++E E +++ E+ A A D L++ K ++E
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEG-KKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQQEL 1429
Query: 230 ------------------ERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHE-SRR 270
++++K+++ AEE + + R + E + +E S
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 271 RFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIH 330
R LE E + +EE E+ K +KA+ + K+ + +EK + +
Sbjct: 1490 RALE-----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 331 NFLSELLKEKLDNEDMIIARDIAEAEAE---------WEKREREKDEKNKAELKTIAEYR 381
+ E+ + + ED + A + A+ E +E+ + +DE+N+ + + +
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 382 AIVMKNKEEEERQRKI--EAKEQLLAVMK-----ADQIFWEHEKE----KKCKADKE--H 428
E+E +QR + AK++L +K AD E+ +K +A +
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 429 QEVQDAHIQQ---MAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
+E++DA + A K N K+AK E D +L E L A + AR+ +LE E
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER------ARKQADLEKE 1711
Score = 55.5 bits (132), Expect = 1e-07
Identities = 94/451 (20%), Positives = 188/451 (41%), Gaps = 68/451 (15%)
Query: 57 RIQDSLDRLTREAACLRA-----ERKAKKEMHLRSQEVVKHWTNTYAGMKEQ-KLEAKKK 110
R+Q LD L + R E+K +K L ++E K+ ++ YA +++ + EA++K
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREK 1481
Query: 111 RDEEIEAERQI---LDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFH----SGLLLSR 163
+ + R + L+ +EE+ + K KA + + + KN H S L
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 164 VMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIK 223
M+E Q+E + ++++ + + +L++N++ + + + R + + +Q+
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 224 EHEEE-EERRKKYEEKDAEEIKRQNALYEIEMRKKLE-KKREEMHESRRRFLEHMQDKHI 281
E+E E E+ RK+ A + K + L ++E++ K REE + R+ M+D
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF-- 1657
Query: 282 IKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKL 341
Q+E ED + ++ + KE E + + L
Sbjct: 1658 -------QRELEDARA-----SRDEIFATAKENEKKA--------------------KSL 1685
Query: 342 DNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRA-----------IVMKNKEE 390
+ + M + D+A AE ++ + EK+E + +++ A I +E
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 391 EERQRKIEAKEQLL--AVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQ 448
EE Q +EA + A +A+Q+ E E+ E Q + ++K + +
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1805
Query: 449 --AKQAELDYCRLTEALVAEKEKEFQDYARE 477
K EA +A+ E++ + ARE
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Score = 49.7 bits (117), Expect = 7e-06
Identities = 79/401 (19%), Positives = 160/401 (39%), Gaps = 49/401 (12%)
Query: 5 SEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKR-IQDSLD 63
S++ +AK T+++N E + L + K + + + ++ KR ++
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL---EKLKRKLEGDAS 1065
Query: 64 RLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILD 123
+ A L+A+ K + +E ++ QK A KK E E I D
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISD 1122
Query: 124 LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDK 183
L+E++ + + E K+ + E +K L + Q E R +
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTE-----LEDTLDSTATQQELRAKR----- 1172
Query: 184 KWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEI 243
EQ ++KA EE E + +E ++++ E E+ +R K +K+ + +
Sbjct: 1173 ---EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 244 KRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKA 303
+++NA E+R + K+E +EH + K + E Q + + E+ R +
Sbjct: 1230 EKENADLAGELRVLGQAKQE---------VEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 304 KKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRE 363
K +Q E E+ T L E + I +A+D+A ++ + +
Sbjct: 1281 KVHKLQ--NEVESVTGMLNEAEGKAIK-----------------LAKDVASLSSQLQDTQ 1321
Query: 364 REKDEKNKAELKTIAEYRAI-VMKNKEEEERQRKIEAKEQL 403
E+ + +L + R + +N +++ ++EAK+ L
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 84.3 bits (207), Expect = 3e-16
Identities = 111/527 (21%), Positives = 230/527 (43%), Gaps = 81/527 (15%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAER 76
+ K ++ EE+ L + QQ +E K ++ +LT E L+ +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKA---ENELKELEQKHSQLTEEKNLLQEQL 903
Query: 77 KAKKEMHLRSQEV------VKHWTNTYAGMKEQKLEAKKKRDEEIEAER-----QILDLE 125
+A+ E++ ++E+ K E +LE ++ R ++++AER Q+LDLE
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 126 EEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKW 185
E++ ++ ++ ++ K ++K +L+ ++ + +K+ ++K
Sbjct: 964 EQLEEEEAARQKLQLEK---VTAEAKIKKLEDEILV----------MDDQNNKLSKERKL 1010
Query: 186 EEQLKLNIEKAFKEEQEKA------EKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD 239
E+ ++ EE+EKA + +H ++ + LK+ ++ +E E+ K+ E D
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 240 AEEIKRQNALYE---IEMRKKLEKKREEMHESRRRFLEHM-QDKHIIKAVEQQQ------ 289
A + Q A + E++ +L KK EE+ + R + + Q + +K + + +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEA------------ETHRLMEKRRERIHNFLSELL 337
QE+ D + KA+K+ +G+E EA T + + +RE+ L + L
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 338 KEKLDNEDMII-------ARDIAEAEAEWE--KREREKDEKNKAELK-----TIAEYRAI 383
E+ + + + A+ + E + E KR + +KNK L+ E R +
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 384 VMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNK 443
+E E +++K+EA+ Q L +D E+ + DK H+ + N+
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSD-----GERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 444 FNAKQAKQAELDYCRL------TEALVAEKEKEFQDYAREVIELESE 484
K K A+ D L T+ L+ E+ ++ + + ++ +LE E
Sbjct: 1306 AEGKAIKLAK-DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
Score = 65.5 bits (158), Expect = 1e-10
Identities = 92/430 (21%), Positives = 188/430 (43%), Gaps = 65/430 (15%)
Query: 78 AKKEMHLRSQEVVKHWTNTYAGM----------KEQKLEAKKKRDEEIEAERQILDLEEE 127
AK++ L + +V++ Y + K + L +++EE++A+ E+E
Sbjct: 814 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAK------EDE 867
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERD--AQIEFRKSKIKSDKKW 185
+ K +R++ EN + + Q LL ++ E + A+ E + ++ + K+
Sbjct: 868 LQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 926
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYE-EKDAEEIK 244
E++ +E +EE+++ ++ ER +A+ L ++ EEEE R+K + EK E K
Sbjct: 927 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986
Query: 245 RQNALYEI----EMRKKLEKKREEM-------------HESRRRFLEHMQDKHIIKAVEQ 287
+ EI + KL K+R+ + E + + L +++KH E
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 288 QQQEEEDEKMRKFIKAKKRLIQMG-----------KEKEAETHRLMEKRRERIHNFLSEL 336
+ + +++EK R+ ++ KR ++ + + AE + K+ E + L+ L
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 337 LKEKLDNEDMIIARDIAEAEA---------EWEKREREKDEKNKAEL-KTIAEYRAIVMK 386
E + + + I E E + E+ R K EK K +L + + + +
Sbjct: 1107 DDEIAQKNNAL--KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 387 NKEEEERQRKIEAK-EQLLAVMK--ADQIFWEHEKEKKCKADKEHQEVQD--AHIQQMAK 441
+ Q+++ AK EQ + V+K D+ HE + + K Q V++ ++Q +
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 442 NKFNAKQAKQ 451
K N + KQ
Sbjct: 1225 AKANLDKNKQ 1234
Score = 60.8 bits (146), Expect = 3e-09
Identities = 102/490 (20%), Positives = 207/490 (42%), Gaps = 51/490 (10%)
Query: 2 DTSSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDS 61
+T + L R AKE E R ++ + L+ SK D+ + + ++
Sbjct: 1489 ETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 62 LDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI--EAER 119
++ + + L E +A ++ LR + ++ G E+ L+A+ +++EE + +R
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQ----ALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKI 179
Q+ + E E+ + K++ AK+ +++ L L + D+ I+ R+ I
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKK-------KLEGDLKDLEL-----QADSAIKGREEAI 1651
Query: 180 KSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD 239
K +K + Q+K F+ E E A E A AK E E++ K E D
Sbjct: 1652 KQLRKLQAQMK-----DFQRELEDARASRDEIFATAK-----------ENEKKAKSLEAD 1695
Query: 240 AEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEH----MQDKHIIKAVEQQQQEEEDE 295
+++ A E RK+ + ++EE+ E L +K ++A Q +EE +E
Sbjct: 1696 LMQLQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Query: 296 KMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEA 355
+ R+ + ++ E ++ L +R N E +++L+ ++ E
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN---ESARQQLERQNK-------EL 1804
Query: 356 EAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWE 415
++ + E K K+ + + A + + E+E R+++ K K +I +
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 416 HEKEKK-CKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDY 474
E E+K + KE E +A ++Q+ + A++ Q R + + E + +
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 475 AREVIELESE 484
REV L+S+
Sbjct: 1925 GREVNALKSK 1934
Score = 59.3 bits (142), Expect = 9e-09
Identities = 98/479 (20%), Positives = 203/479 (42%), Gaps = 72/479 (15%)
Query: 56 KRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI 115
K+++ + L ++ C ER A+ E++ + ++ + + E + +A K +
Sbjct: 1262 KKLEAQVQEL--QSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 116 EAERQILDLEEEIYKQGKRK-----KAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDA 170
Q+ D +E + ++ ++K K + ++ Q + + + L R + +
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378
Query: 171 QIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEE- 229
Q+ K K++ E L+ +K F++E E +++ E+ A A D L++ K ++E
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEG-KKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQQEL 1436
Query: 230 ------------------ERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHE-SRR 270
++++K+++ AEE + + R + E + +E S
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 271 RFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIH 330
R LE E + +EE E+ K +KA+ + K+ + +EK + +
Sbjct: 1497 RALE-----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545
Query: 331 NFLSELLKEKLDNEDMIIARDIAEAEAE---------WEKREREKDEKNKAELKTIAEYR 381
+ E+ + + ED + A + A+ E +E+ + +DE+N+ + + +
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 382 AIVMKNKEEEERQRKI--EAKEQLLAVMK-----ADQIFWEHEKE----KKCKADKE--H 428
E+E +QR + AK++L +K AD E+ +K +A +
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 429 QEVQDAHIQQ---MAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
+E++DA + A K N K+AK E D +L E L A + AR+ +LE E
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER------ARKQADLEKE 1718
Score = 55.5 bits (132), Expect = 1e-07
Identities = 94/451 (20%), Positives = 188/451 (41%), Gaps = 68/451 (15%)
Query: 57 RIQDSLDRLTREAACLRA-----ERKAKKEMHLRSQEVVKHWTNTYAGMKEQ-KLEAKKK 110
R+Q LD L + R E+K +K L ++E K+ ++ YA +++ + EA++K
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREK 1488
Query: 111 RDEEIEAERQI---LDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFH----SGLLLSR 163
+ + R + L+ +EE+ + K KA + + + KN H S L
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 164 VMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIK 223
M+E Q+E + ++++ + + +L++N++ + + + R + + +Q+
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 224 EHEEE-EERRKKYEEKDAEEIKRQNALYEIEMRKKLE-KKREEMHESRRRFLEHMQDKHI 281
E+E E E+ RK+ A + K + L ++E++ K REE + R+ M+D
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF-- 1664
Query: 282 IKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKL 341
Q+E ED + ++ + KE E + + L
Sbjct: 1665 -------QRELEDARA-----SRDEIFATAKENEKKA--------------------KSL 1692
Query: 342 DNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRA-----------IVMKNKEE 390
+ + M + D+A AE ++ + EK+E + +++ A I +E
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 391 EERQRKIEAKEQLL--AVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQ 448
EE Q +EA + A +A+Q+ E E+ E Q + ++K + +
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1812
Query: 449 --AKQAELDYCRLTEALVAEKEKEFQDYARE 477
K EA +A+ E++ + ARE
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Score = 49.7 bits (117), Expect = 7e-06
Identities = 79/401 (19%), Positives = 160/401 (39%), Gaps = 49/401 (12%)
Query: 5 SEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKR-IQDSLD 63
S++ +AK T+++N E + L + K + + + ++ KR ++
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL---EKLKRKLEGDAS 1072
Query: 64 RLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILD 123
+ A L+A+ K + +E ++ QK A KK E E I D
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISD 1129
Query: 124 LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDK 183
L+E++ + + E K+ + E +K L + Q E R +
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTE-----LEDTLDSTATQQELRAKR----- 1179
Query: 184 KWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEI 243
EQ ++KA EE E + +E ++++ E E+ +R K +K+ + +
Sbjct: 1180 ---EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 244 KRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKA 303
+++NA E+R + K+E +EH + K + E Q + + E+ R +
Sbjct: 1237 EKENADLAGELRVLGQAKQE---------VEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 304 KKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRE 363
K +Q E E+ T L E + I +A+D+A ++ + +
Sbjct: 1288 KVHKLQ--NEVESVTGMLNEAEGKAIK-----------------LAKDVASLSSQLQDTQ 1328
Query: 364 REKDEKNKAELKTIAEYRAI-VMKNKEEEERQRKIEAKEQL 403
E+ + +L + R + +N +++ ++EAK+ L
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 84.3 bits (207), Expect = 3e-16
Identities = 111/527 (21%), Positives = 230/527 (43%), Gaps = 81/527 (15%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAER 76
+ K ++ EE+ L + QQ +E K ++ +LT E L+ +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKA---ENELKELEQKHSQLTEEKNLLQEQL 903
Query: 77 KAKKEMHLRSQEV------VKHWTNTYAGMKEQKLEAKKKRDEEIEAER-----QILDLE 125
+A+ E++ ++E+ K E +LE ++ R ++++AER Q+LDLE
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 126 EEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKW 185
E++ ++ ++ ++ K ++K +L+ ++ + +K+ ++K
Sbjct: 964 EQLEEEEAARQKLQLEK---VTAEAKIKKLEDEILV----------MDDQNNKLSKERKL 1010
Query: 186 EEQLKLNIEKAFKEEQEKA------EKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD 239
E+ ++ EE+EKA + +H ++ + LK+ ++ +E E+ K+ E D
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1070
Query: 240 AEEIKRQNALYE---IEMRKKLEKKREEMHESRRRFLEHM-QDKHIIKAVEQQQ------ 289
A + Q A + E++ +L KK EE+ + R + + Q + +K + + +
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1130
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEA------------ETHRLMEKRRERIHNFLSELL 337
QE+ D + KA+K+ +G+E EA T + + +RE+ L + L
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 338 KEKLDNEDMII-------ARDIAEAEAEWE--KREREKDEKNKAELK-----TIAEYRAI 383
E+ + + + A+ + E + E KR + +KNK L+ E R +
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 384 VMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNK 443
+E E +++K+EA+ Q L +D E+ + DK H+ + N+
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSD-----GERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 444 FNAKQAKQAELDYCRL------TEALVAEKEKEFQDYAREVIELESE 484
K K A+ D L T+ L+ E+ ++ + + ++ +LE E
Sbjct: 1306 AEGKAIKLAK-DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
Score = 65.5 bits (158), Expect = 1e-10
Identities = 92/430 (21%), Positives = 188/430 (43%), Gaps = 65/430 (15%)
Query: 78 AKKEMHLRSQEVVKHWTNTYAGM----------KEQKLEAKKKRDEEIEAERQILDLEEE 127
AK++ L + +V++ Y + K + L +++EE++A+ E+E
Sbjct: 814 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAK------EDE 867
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERD--AQIEFRKSKIKSDKKW 185
+ K +R++ EN + + Q LL ++ E + A+ E + ++ + K+
Sbjct: 868 LQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 926
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYE-EKDAEEIK 244
E++ +E +EE+++ ++ ER +A+ L ++ EEEE R+K + EK E K
Sbjct: 927 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986
Query: 245 RQNALYEI----EMRKKLEKKREEM-------------HESRRRFLEHMQDKHIIKAVEQ 287
+ EI + KL K+R+ + E + + L +++KH E
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 288 QQQEEEDEKMRKFIKAKKRLIQMG-----------KEKEAETHRLMEKRRERIHNFLSEL 336
+ + +++EK R+ ++ KR ++ + + AE + K+ E + L+ L
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 337 LKEKLDNEDMIIARDIAEAEA---------EWEKREREKDEKNKAEL-KTIAEYRAIVMK 386
E + + + I E E + E+ R K EK K +L + + + +
Sbjct: 1107 DDEIAQKNNAL--KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1164
Query: 387 NKEEEERQRKIEAK-EQLLAVMK--ADQIFWEHEKEKKCKADKEHQEVQD--AHIQQMAK 441
+ Q+++ AK EQ + V+K D+ HE + + K Q V++ ++Q +
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 442 NKFNAKQAKQ 451
K N + KQ
Sbjct: 1225 AKANLDKNKQ 1234
Score = 60.8 bits (146), Expect = 3e-09
Identities = 102/490 (20%), Positives = 207/490 (42%), Gaps = 51/490 (10%)
Query: 2 DTSSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDS 61
+T + L R AKE E R ++ + L+ SK D+ + + ++
Sbjct: 1489 ETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 62 LDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI--EAER 119
++ + + L E +A ++ LR + ++ G E+ L+A+ +++EE + +R
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQ----ALKGQFERDLQARDEQNEEKRRQLQR 1603
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKI 179
Q+ + E E+ + K++ AK+ +++ L L + D+ I+ R+ I
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKK-------KLEGDLKDLEL-----QADSAIKGREEAI 1651
Query: 180 KSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD 239
K +K + Q+K F+ E E A E A AK E E++ K E D
Sbjct: 1652 KQLRKLQAQMK-----DFQRELEDARASRDEIFATAK-----------ENEKKAKSLEAD 1695
Query: 240 AEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEH----MQDKHIIKAVEQQQQEEEDE 295
+++ A E RK+ + ++EE+ E L +K ++A Q +EE +E
Sbjct: 1696 LMQLQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1754
Query: 296 KMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEA 355
+ R+ + ++ E ++ L +R N E +++L+ ++ E
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN---ESARQQLERQNK-------EL 1804
Query: 356 EAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWE 415
++ + E K K+ + + A + + E+E R+++ K K +I +
Sbjct: 1805 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1864
Query: 416 HEKEKK-CKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDY 474
E E+K + KE E +A ++Q+ + A++ Q R + + E + +
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Query: 475 AREVIELESE 484
REV L+S+
Sbjct: 1925 GREVNALKSK 1934
Score = 59.3 bits (142), Expect = 9e-09
Identities = 98/479 (20%), Positives = 203/479 (42%), Gaps = 72/479 (15%)
Query: 56 KRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI 115
K+++ + L ++ C ER A+ E++ + ++ + + E + +A K +
Sbjct: 1262 KKLEAQVQEL--QSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 116 EAERQILDLEEEIYKQGKRK-----KAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDA 170
Q+ D +E + ++ ++K K + ++ Q + + + L R + +
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378
Query: 171 QIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEE- 229
Q+ K K++ E L+ +K F++E E +++ E+ A A D L++ K ++E
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEG-KKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQQEL 1436
Query: 230 ------------------ERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHE-SRR 270
++++K+++ AEE + + R + E + +E S
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 271 RFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIH 330
R LE E + +EE E+ K +KA+ + K+ + +EK + +
Sbjct: 1497 RALE-----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545
Query: 331 NFLSELLKEKLDNEDMIIARDIAEAEAE---------WEKREREKDEKNKAELKTIAEYR 381
+ E+ + + ED + A + A+ E +E+ + +DE+N+ + + +
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 382 AIVMKNKEEEERQRKI--EAKEQLLAVMK-----ADQIFWEHEKE----KKCKADKE--H 428
E+E +QR + AK++L +K AD E+ +K +A +
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 429 QEVQDAHIQQ---MAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
+E++DA + A K N K+AK E D +L E L A + AR+ +LE E
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER------ARKQADLEKE 1718
Score = 55.5 bits (132), Expect = 1e-07
Identities = 94/451 (20%), Positives = 188/451 (41%), Gaps = 68/451 (15%)
Query: 57 RIQDSLDRLTREAACLRA-----ERKAKKEMHLRSQEVVKHWTNTYAGMKEQ-KLEAKKK 110
R+Q LD L + R E+K +K L ++E K+ ++ YA +++ + EA++K
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREK 1488
Query: 111 RDEEIEAERQI---LDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFH----SGLLLSR 163
+ + R + L+ +EE+ + K KA + + + KN H S L
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 164 VMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIK 223
M+E Q+E + ++++ + + +L++N++ + + + R + + +Q+
Sbjct: 1547 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1606
Query: 224 EHEEE-EERRKKYEEKDAEEIKRQNALYEIEMRKKLE-KKREEMHESRRRFLEHMQDKHI 281
E+E E E+ RK+ A + K + L ++E++ K REE + R+ M+D
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF-- 1664
Query: 282 IKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKL 341
Q+E ED + ++ + KE E + + L
Sbjct: 1665 -------QRELEDARA-----SRDEIFATAKENEKKA--------------------KSL 1692
Query: 342 DNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRA-----------IVMKNKEE 390
+ + M + D+A AE ++ + EK+E + +++ A I +E
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 391 EERQRKIEAKEQLL--AVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQ 448
EE Q +EA + A +A+Q+ E E+ E Q + ++K + +
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1812
Query: 449 --AKQAELDYCRLTEALVAEKEKEFQDYARE 477
K EA +A+ E++ + ARE
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843
Score = 49.7 bits (117), Expect = 7e-06
Identities = 79/401 (19%), Positives = 160/401 (39%), Gaps = 49/401 (12%)
Query: 5 SEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKR-IQDSLD 63
S++ +AK T+++N E + L + K + + + ++ KR ++
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL---EKLKRKLEGDAS 1072
Query: 64 RLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILD 123
+ A L+A+ K + +E ++ QK A KK E E I D
Sbjct: 1073 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISD 1129
Query: 124 LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDK 183
L+E++ + + E K+ + E +K L + Q E R +
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTE-----LEDTLDSTATQQELRAKR----- 1179
Query: 184 KWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEI 243
EQ ++KA EE E + +E ++++ E E+ +R K +K+ + +
Sbjct: 1180 ---EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236
Query: 244 KRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKA 303
+++NA E+R + K+E +EH + K + E Q + + E+ R +
Sbjct: 1237 EKENADLAGELRVLGQAKQE---------VEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 304 KKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRE 363
K +Q E E+ T L E + I +A+D+A ++ + +
Sbjct: 1288 KVHKLQ--NEVESVTGMLNEAEGKAIK-----------------LAKDVASLSSQLQDTQ 1328
Query: 364 REKDEKNKAELKTIAEYRAI-VMKNKEEEERQRKIEAKEQL 403
E+ + +L + R + +N +++ ++EAK+ L
Sbjct: 1329 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 84.3 bits (207), Expect = 3e-16
Identities = 111/527 (21%), Positives = 230/527 (43%), Gaps = 81/527 (15%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAER 76
+ K ++ EE+ L + QQ +E K ++ +LT E L+ +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKA---ENELKELEQKHSQLTEEKNLLQEQL 896
Query: 77 KAKKEMHLRSQEV------VKHWTNTYAGMKEQKLEAKKKRDEEIEAER-----QILDLE 125
+A+ E++ ++E+ K E +LE ++ R ++++AER Q+LDLE
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 126 EEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKW 185
E++ ++ ++ ++ K ++K +L+ ++ + +K+ ++K
Sbjct: 957 EQLEEEEAARQKLQLEK---VTAEAKIKKLEDEILV----------MDDQNNKLSKERKL 1003
Query: 186 EEQLKLNIEKAFKEEQEKA------EKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD 239
E+ ++ EE+EKA + +H ++ + LK+ ++ +E E+ K+ E D
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD 1063
Query: 240 AEEIKRQNALYE---IEMRKKLEKKREEMHESRRRFLEHM-QDKHIIKAVEQQQ------ 289
A + Q A + E++ +L KK EE+ + R + + Q + +K + + +
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL 1123
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEA------------ETHRLMEKRRERIHNFLSELL 337
QE+ D + KA+K+ +G+E EA T + + +RE+ L + L
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 338 KEKLDNEDMII-------ARDIAEAEAEWE--KREREKDEKNKAELK-----TIAEYRAI 383
E+ + + + A+ + E + E KR + +KNK L+ E R +
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 384 VMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNK 443
+E E +++K+EA+ Q L +D E+ + DK H+ + N+
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSD-----GERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 444 FNAKQAKQAELDYCRL------TEALVAEKEKEFQDYAREVIELESE 484
K K A+ D L T+ L+ E+ ++ + + ++ +LE E
Sbjct: 1299 AEGKAIKLAK-DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
Score = 65.5 bits (158), Expect = 1e-10
Identities = 92/430 (21%), Positives = 188/430 (43%), Gaps = 65/430 (15%)
Query: 78 AKKEMHLRSQEVVKHWTNTYAGM----------KEQKLEAKKKRDEEIEAERQILDLEEE 127
AK++ L + +V++ Y + K + L +++EE++A+ E+E
Sbjct: 807 AKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAK------EDE 860
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERD--AQIEFRKSKIKSDKKW 185
+ K +R++ EN + + Q LL ++ E + A+ E + ++ + K+
Sbjct: 861 LQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQE 919
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYE-EKDAEEIK 244
E++ +E +EE+++ ++ ER +A+ L ++ EEEE R+K + EK E K
Sbjct: 920 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979
Query: 245 RQNALYEI----EMRKKLEKKREEM-------------HESRRRFLEHMQDKHIIKAVEQ 287
+ EI + KL K+R+ + E + + L +++KH E
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 288 QQQEEEDEKMRKFIKAKKRLIQMG-----------KEKEAETHRLMEKRRERIHNFLSEL 336
+ + +++EK R+ ++ KR ++ + + AE + K+ E + L+ L
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 337 LKEKLDNEDMIIARDIAEAEA---------EWEKREREKDEKNKAEL-KTIAEYRAIVMK 386
E + + + I E E + E+ R K EK K +L + + + +
Sbjct: 1100 DDEIAQKNNAL--KKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED 1157
Query: 387 NKEEEERQRKIEAK-EQLLAVMK--ADQIFWEHEKEKKCKADKEHQEVQD--AHIQQMAK 441
+ Q+++ AK EQ + V+K D+ HE + + K Q V++ ++Q +
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 442 NKFNAKQAKQ 451
K N + KQ
Sbjct: 1218 AKANLDKNKQ 1227
Score = 60.8 bits (146), Expect = 3e-09
Identities = 102/490 (20%), Positives = 207/490 (42%), Gaps = 51/490 (10%)
Query: 2 DTSSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDS 61
+T + L R AKE E R ++ + L+ SK D+ + + ++
Sbjct: 1482 ETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 62 LDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI--EAER 119
++ + + L E +A ++ LR + ++ G E+ L+A+ +++EE + +R
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQ----ALKGQFERDLQARDEQNEEKRRQLQR 1596
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKI 179
Q+ + E E+ + K++ AK+ +++ L L + D+ I+ R+ I
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKK-------KLEGDLKDLEL-----QADSAIKGREEAI 1644
Query: 180 KSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD 239
K +K + Q+K F+ E E A E A AK E E++ K E D
Sbjct: 1645 KQLRKLQAQMK-----DFQRELEDARASRDEIFATAK-----------ENEKKAKSLEAD 1688
Query: 240 AEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEH----MQDKHIIKAVEQQQQEEEDE 295
+++ A E RK+ + ++EE+ E L +K ++A Q +EE +E
Sbjct: 1689 LMQLQEDLAAAE-RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE 1747
Query: 296 KMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEA 355
+ R+ + ++ E ++ L +R N E +++L+ ++ E
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN---ESARQQLERQNK-------EL 1797
Query: 356 EAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWE 415
++ + E K K+ + + A + + E+E R+++ K K +I +
Sbjct: 1798 RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ 1857
Query: 416 HEKEKK-CKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDY 474
E E+K + KE E +A ++Q+ + A++ Q R + + E + +
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Query: 475 AREVIELESE 484
REV L+S+
Sbjct: 1918 GREVNALKSK 1927
Score = 59.3 bits (142), Expect = 9e-09
Identities = 98/479 (20%), Positives = 203/479 (42%), Gaps = 72/479 (15%)
Query: 56 KRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI 115
K+++ + L ++ C ER A+ E++ + ++ + + E + +A K +
Sbjct: 1255 KKLEAQVQEL--QSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 116 EAERQILDLEEEIYKQGKRK-----KAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDA 170
Q+ D +E + ++ ++K K + ++ Q + + + L R + +
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371
Query: 171 QIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEE- 229
Q+ K K++ E L+ +K F++E E +++ E+ A A D L++ K ++E
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEG-KKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQQEL 1429
Query: 230 ------------------ERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHE-SRR 270
++++K+++ AEE + + R + E + +E S
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 271 RFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIH 330
R LE E + +EE E+ K +KA+ + K+ + +EK + +
Sbjct: 1490 RALE-----------EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 331 NFLSELLKEKLDNEDMIIARDIAEAEAE---------WEKREREKDEKNKAELKTIAEYR 381
+ E+ + + ED + A + A+ E +E+ + +DE+N+ + + +
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 382 AIVMKNKEEEERQRKI--EAKEQLLAVMK-----ADQIFWEHEKE----KKCKADKE--H 428
E+E +QR + AK++L +K AD E+ +K +A +
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 429 QEVQDAHIQQ---MAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
+E++DA + A K N K+AK E D +L E L A + AR+ +LE E
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER------ARKQADLEKE 1711
Score = 55.5 bits (132), Expect = 1e-07
Identities = 94/451 (20%), Positives = 188/451 (41%), Gaps = 68/451 (15%)
Query: 57 RIQDSLDRLTREAACLRA-----ERKAKKEMHLRSQEVVKHWTNTYAGMKEQ-KLEAKKK 110
R+Q LD L + R E+K +K L ++E K+ ++ YA +++ + EA++K
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE--KNISSKYADERDRAEAEAREK 1481
Query: 111 RDEEIEAERQI---LDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFH----SGLLLSR 163
+ + R + L+ +EE+ + K KA + + + KN H S L
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 164 VMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIK 223
M+E Q+E + ++++ + + +L++N++ + + + R + + +Q+
Sbjct: 1540 QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH 1599
Query: 224 EHEEE-EERRKKYEEKDAEEIKRQNALYEIEMRKKLE-KKREEMHESRRRFLEHMQDKHI 281
E+E E E+ RK+ A + K + L ++E++ K REE + R+ M+D
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDF-- 1657
Query: 282 IKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKL 341
Q+E ED + ++ + KE E + + L
Sbjct: 1658 -------QRELEDARA-----SRDEIFATAKENEKKA--------------------KSL 1685
Query: 342 DNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRA-----------IVMKNKEE 390
+ + M + D+A AE ++ + EK+E + +++ A I +E
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 391 EERQRKIEAKEQLL--AVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQ 448
EE Q +EA + A +A+Q+ E E+ E Q + ++K + +
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1805
Query: 449 --AKQAELDYCRLTEALVAEKEKEFQDYARE 477
K EA +A+ E++ + ARE
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836
Score = 49.7 bits (117), Expect = 7e-06
Identities = 79/401 (19%), Positives = 160/401 (39%), Gaps = 49/401 (12%)
Query: 5 SEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKR-IQDSLD 63
S++ +AK T+++N E + L + K + + + ++ KR ++
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL---EKLKRKLEGDAS 1065
Query: 64 RLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILD 123
+ A L+A+ K + +E ++ QK A KK E E I D
Sbjct: 1066 DFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE---LEGHISD 1122
Query: 124 LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDK 183
L+E++ + + E K+ + E +K L + Q E R +
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTE-----LEDTLDSTATQQELRAKR----- 1172
Query: 184 KWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEI 243
EQ ++KA EE E + +E ++++ E E+ +R K +K+ + +
Sbjct: 1173 ---EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229
Query: 244 KRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKA 303
+++NA E+R + K+E +EH + K + E Q + + E+ R +
Sbjct: 1230 EKENADLAGELRVLGQAKQE---------VEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 304 KKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKRE 363
K +Q E E+ T L E + I +A+D+A ++ + +
Sbjct: 1281 KVHKLQ--NEVESVTGMLNEAEGKAIK-----------------LAKDVASLSSQLQDTQ 1321
Query: 364 REKDEKNKAELKTIAEYRAI-VMKNKEEEERQRKIEAKEQL 403
E+ + +L + R + +N +++ ++EAK+ L
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 83.6 bits (205), Expect = 4e-16
Identities = 79/337 (23%), Positives = 169/337 (50%), Gaps = 31/337 (9%)
Query: 84 LRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQ 143
L S+E+ K + +T+ ++E+K + +K+R +EIE ER+ + E E ++ + ++ ++
Sbjct: 276 LISREISK-FRDTHKKLEEEKGKKEKER-QEIEKERRERERERERERERRERERERERER 333
Query: 144 YQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLK---LNIEKAFKEE 200
+ + ER + R KERD + + + + ++ ++ K + EK+ E
Sbjct: 334 EREKEKERERERERDRDRDRT-KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRE 392
Query: 201 QEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEK 260
+E+ +R RER + ++ +E E E ER ++ ++K E ++A YE R+KLE+
Sbjct: 393 REREREREREREREREREREREREREREREREREKDKKRDREEDEEDA-YE---RRKLER 448
Query: 261 KREEMHESRRRFLEHMQDKHIIKAVEQQQQ-EEEDEKMRKFIKAKKRLIQMGKEKEAETH 319
K E + + L++ + + K E +++ E E+E+ R+ K KRL + ++ + +
Sbjct: 449 KLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRD 508
Query: 320 --------RLMEKRRERIHNFLSELLKEKLDNEDM------IIARDIAEAEAEWEKRERE 365
L ++ R+R ++ K + E++ ++A + +AE ++ E+E
Sbjct: 509 DPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQE 568
Query: 366 KDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQ 402
+ + + ++K E +EEEE+Q K E +E+
Sbjct: 569 AERRRQPQIKQEPE------SEEEEEEKQEKEEKREE 599
Score = 67.0 bits (162), Expect = 4e-11
Identities = 94/418 (22%), Positives = 179/418 (42%), Gaps = 46/418 (11%)
Query: 55 WKRIQDSLDRLTREAAC--------LRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLE 106
WKR+Q + +L C LRA R + +VK T A + E K +
Sbjct: 116 WKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAK 175
Query: 107 AKKKRDEEIEAERQILDLEEEIYKQGKRK-KAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
KK + E D EE + ++ KR+ + I+ A + + N S
Sbjct: 176 -KKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPS-------- 226
Query: 166 KERDAQIEFRKSKIKSD--KKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIK 223
+E D+ +K + K D +++ + KE+ E +R ++++ K
Sbjct: 227 QESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRD 286
Query: 224 EHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIK 283
H++ EE + K E++ R+++EK+R E R R E + + +
Sbjct: 287 THKKLEEEKGKKEKE----------------RQEIEKERRERERERERERERRERERERE 330
Query: 284 AVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDN 343
++++E+E E+ R+ + + R + ++++ E R ++ R N +EK +
Sbjct: 331 REREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRD 390
Query: 344 EDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEE----RQRKIEA 399
+ R+ E E E E RERE++ + + E + E +++EE+E +RK+E
Sbjct: 391 RERERERE-RERERERE-REREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448
Query: 400 K-EQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDY 456
K + A + WE + KK + ++ E ++ ++MAK AK+ K+ DY
Sbjct: 449 KLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK---EAKRLKEFLEDY 503
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/278 (24%), Positives = 132/278 (47%), Gaps = 25/278 (8%)
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDE 113
E +R +D T+E R + + RS + K + + ++++ E +++R+
Sbjct: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERER 401
Query: 114 EIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIE 173
E E ER+ E E ++ +R++ E K + + E ++ + L R ++E++A +
Sbjct: 402 ERERERE---REREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQ 458
Query: 174 FRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
R K WE + + + +++E E+ E+R RE AK LK+ E +++
Sbjct: 459 ERL------KNWEIRERKKTRE-YEKEAEREEERRREMAKEAK-RLKEFLEDYDDDRDDP 510
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKK-REEMHESRRRFLE--HMQDKHIIKAVEQQ-- 288
KY A + + ++ E+E ++ K+ +EE+ E R+R L H ++ +EQ+
Sbjct: 511 KYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAE 570
Query: 289 -------QQE--EEDEKMRKFIKAKKRLIQMGKEKEAE 317
+QE E+E+ K K +KR M +E+E E
Sbjct: 571 RRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPE 608
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.4 bits (202), Expect = 1e-15
Identities = 109/443 (24%), Positives = 199/443 (44%), Gaps = 62/443 (13%)
Query: 56 KRIQDSLDRLTREAACLRAERKAKKE-MHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEE 114
KR ++++ + L +E++A +E + R QE+ K +K+ + K K +
Sbjct: 296 KRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK--------IKDLHMAEKTKLITQ 347
Query: 115 IEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEF 174
+ + +++ E+ + I K+ Q ++T +K L SR+ + E
Sbjct: 348 LRDAKNLIEQLEQ-----DKGMVIAETKR-QMHETLEMKEEEIAQLRSRIKQMTTQGEEL 401
Query: 175 RKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEE---- 230
R+ K KS++ E+L EKA Q K E+ R+ A + +K I++ EEE
Sbjct: 402 REQKEKSERAAFEEL----EKALSTAQ-KTEEARRKLKAEMDEQIKTIEKTSEEERISLQ 456
Query: 231 -------------RRKKYEEKDAEEIK---RQNALYEIEMRKKLEKKREEMHESRRRFLE 274
+K EE+ A+ K ++ A E E+ KKL+ + E E + LE
Sbjct: 457 QELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALE 516
Query: 275 HMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLS 334
Q +++ + Q+++++E + + KK ++ + K + + E R RI S
Sbjct: 517 KSQSEYL--KISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 335 ELLKEKLDNEDMIIARDIA-EAEAEWEKRERE---KDEKNKAELKTIAEYRAIVMKNKEE 390
L K +N++ ++D+A EAE K +E EK+K EL++ +K++++
Sbjct: 575 SLEKSLQENKNQ--SKDLAVHLEAEKNKHNKEITVMVEKHKTELES--------LKHQQD 624
Query: 391 EERQRKIEA-KEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQA 449
K++ K+Q M+ + E EKE K DKE + AHI++M +
Sbjct: 625 ALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK-DKE--IIFQAHIEEMNEKTLEKLDV 681
Query: 450 KQAELD--YCRLTEALVAEKEKE 470
KQ EL+ L+E L A + E
Sbjct: 682 KQTELESLSSELSEVLKARHKLE 704
Score = 72.4 bits (176), Expect = 1e-12
Identities = 100/502 (19%), Positives = 224/502 (44%), Gaps = 66/502 (13%)
Query: 17 RAKESTEIRNSEEDQVLYLP--LLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRA 74
R KE+ E + E+QV + L K +L+ V + + + ++ DRL E+A A
Sbjct: 1579 RVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLA 1638
Query: 75 ERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI-EAERQILDLEEEIYKQGK 133
E K K E Q++ + M+E++ + KK + + E ++ + E E++ +
Sbjct: 1639 ELKRKAE-----QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEE 1693
Query: 134 RKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNI 193
+ K++E+++ KN + + Q + + + E+ KL +
Sbjct: 1694 KLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL-L 1752
Query: 194 EKAFKEEQEKA----EKRHRERVALAKDHLKQIKEHEEE----------EERRKKYEEKD 239
++ +E++E E R + + L K + K+HE++ EE+ KKY
Sbjct: 1753 QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIV 1812
Query: 240 AEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRK 299
A+ ++++ I+ ++ LE +++ ++ +Q+K + + +Q+ +E D + +
Sbjct: 1813 AQHVEKEGGKNNIQAKQNLENVFDDVQKT-------LQEKELTCQILEQKIKELDSCLVR 1865
Query: 300 FIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNED---MIIARDIAEAE 356
+ + ++M +E ++ +L ++ N +ELL+E + + ++ + ++ E
Sbjct: 1866 --QKEVHRVEM-EELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNME 1922
Query: 357 AEWEK-------REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKA 409
A+ EREK + K ++ + R + ++E +++ +I KE
Sbjct: 1923 AQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRML----RKEHQQELEILKKE-------- 1970
Query: 410 DQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQA-KQAELDYCRLTEALVAEKE 468
++ E+E+K K ++E E++ + +FN + A K+ EL E + E
Sbjct: 1971 ----YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL------EMTIKETI 2020
Query: 469 KEFQDYAREVIELESETTNKYI 490
+ Q+ E++E E TN+ +
Sbjct: 2021 NKAQEVEAELLESHQEETNQLL 2042
Score = 70.5 bits (171), Expect = 4e-12
Identities = 91/425 (21%), Positives = 186/425 (43%), Gaps = 64/425 (15%)
Query: 100 MKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGL 159
+KE +++ + K E E + QI L+EE+ +Q KR ++ + + E+ ++
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519
Query: 160 LLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHL 219
L S+ + + + + I+ + ++ + K ++ + H+E V L
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIE---------SLNEVLKNYNQQKDIEHKELV----QKL 1566
Query: 220 KQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDK 279
+ +E EE++ R K E + + + +N +Y M+ +LE K++E+ L +
Sbjct: 1567 QHFQELGEEKDNRVK--EAEEKILTLENQVY--SMKAELETKKKELEHVN---LSVKSKE 1619
Query: 280 HIIKAVEQQQQEEEDEKM--------RKFIKAKKRLIQMGKEKEAETHRLME-------- 323
+KA+E + + E K+ +K KK+L+ +EKE + + E
Sbjct: 1620 EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT 1679
Query: 324 --KRRERIHNFLSELLK--EKLDNEDMIIARDIAEAEAEWEKREREK--------DEKNK 371
+ RER + L E LK E +E +I+ R A E+ E + +EK
Sbjct: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739
Query: 372 AELKTIAEYRAIVMKNKEEEER------QRKIEAKEQLLAVMKA------DQIFWEHEKE 419
+ + E ++ + +E+E + + + +E+L+ + A DQ H +E
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799
Query: 420 KKCKADKEHQEVQDAHIQ-QMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREV 478
+ + +K++ + H++ + KN AKQ + D + T + EKE Q +++
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKT---LQEKELTCQILEQKI 1856
Query: 479 IELES 483
EL+S
Sbjct: 1857 KELDS 1861
Score = 59.3 bits (142), Expect = 9e-09
Identities = 110/517 (21%), Positives = 209/517 (40%), Gaps = 109/517 (21%)
Query: 59 QDSLDRLTREAA-CLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEA 117
Q L+ L+ E + L+A K ++E+ + + K A M EQK +++ D I+
Sbjct: 683 QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIK- 741
Query: 118 ERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKS 177
E E+ Q K + Q + ER K+ +KE A +E ++
Sbjct: 742 -------EHEVSIQRTEKALKDQINQLELLLKERDKH----------LKEHQAHVENLEA 784
Query: 178 KIKSDKKWEEQLKLNIE-------------KAFKEE----QEKAEKRHRERVALAK---- 216
IK + +Q ++ KA++E+ Q+K ER+ L K
Sbjct: 785 DIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAE 844
Query: 217 --------------------DHLKQIKEHEEEEERRKK-----YEEKDAEEIKRQNALYE 251
D ++Q+++ E E++ K YE K + K Q +
Sbjct: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 904
Query: 252 IEMRKKLEKKREEMHESRRRFLEHMQDK--------HIIKAVEQQQQEEEDEKMRKFIKA 303
I + K E +M E +++ +E + K HI+ + + + +++KM K +
Sbjct: 905 ILVEK--ENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK 962
Query: 304 KKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMI-----IARDIAEAEAE 358
K + + K+K + ++K E LS+ KEK N M+ + I++A +
Sbjct: 963 AKEMQETLKKKLLDQEAKLKKELENTALELSQ--KEKQFNAKMLEMAQANSAGISDAVSR 1020
Query: 359 WEKREREKDEK-NKAELKTIAEYRAIVMK--NKEEEERQR----KIEAKEQLLAVMKADQ 411
E ++E+ E + + + + +I K N++ EE Q +++ KEQ +A +K
Sbjct: 1021 LETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKI 1080
Query: 412 IFWEHEKEKK-----------CKADKEHQEVQD------AHIQQMAKNKFNAK---QAKQ 451
+ + EKE+ K D E+Q+ AH+ +A+++ K + +
Sbjct: 1081 LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLE 1140
Query: 452 AELDYCRLTEALVAEKEKEFQDYAREVIELESETTNK 488
+L+ + E+ E + A E SE T+K
Sbjct: 1141 VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
Score = 56.6 bits (135), Expect = 6e-08
Identities = 102/516 (19%), Positives = 219/516 (42%), Gaps = 63/516 (12%)
Query: 13 RRCGRAKESTEIRN-SEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAAC 71
+ C ++ ++R +EE L + + L++ ++ K ++ ++ L E
Sbjct: 1267 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEE----KENQIKSMKADIESLVTEKEA 1322
Query: 72 LRAE----RKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEE 127
L+ E ++A E ++ K + + K E K+K+ E +Q+ DL +
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 128 IYKQ---GKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKK 184
+ +++ AI + ++ Y E+ + LL +V + F+ + +K
Sbjct: 1383 LQNSISLSEKEAAISSLRKQ--YDEEKCE------LLDQVQ-----DLSFKVDTLSKEKI 1429
Query: 185 WEEQLKLNIEKAFKEEQEKAEKRHRERVALAKD-----HLKQIKEHEEEEERRKKYEEKD 239
+ + F E ++KA+ R + K+ LK + +E++E+ EE D
Sbjct: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD 1489
Query: 240 AEEIKRQNALYEIEMRK-KLEKKRE----EMHESRRRFLE---HMQDKHI----IKAVEQ 287
+ + E+E K K+EKK E+ R +E H+ K I + V +
Sbjct: 1490 QQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
Query: 288 QQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEK---RRERIHNFLSEL--LKEKLD 342
+++D + ++ ++ + ++G+EK+ EK ++++ +EL K++L+
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1609
Query: 343 NEDMIIARDIAEAEAEWEKREREK-----DEKNKAELKTIAEYRAIVMKNKEEEERQRK- 396
+ ++ + E +A ++ E E + K KAE K A + ++ + +E+EE+ +K
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 397 IEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDY 456
E+ L ++ H E+K K+ E + + + + AKN + ++A+
Sbjct: 1670 TESHLSELNTKLQEREREVHILEEKLKS-VESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728
Query: 457 C---------RLTEALVAEKEKEFQDYAREVIELES 483
C + + + EKEK Q +E E S
Sbjct: 1729 CVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764
Score = 53.5 bits (127), Expect = 5e-07
Identities = 73/377 (19%), Positives = 168/377 (44%), Gaps = 44/377 (11%)
Query: 134 RKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNI 193
R K E YQ Q E+ K L ++ + + R ++++ + + ++Q K ++
Sbjct: 154 RGKYSELVTAYQMLQREKKK-------LQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206
Query: 194 EKAFK---EEQEKAEKRHRERVALAK----------DHLKQIKEHEEEEERRKKYE--EK 238
++ F EE+++ + +V+L K D LK + + E + E K E E
Sbjct: 207 QEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES 266
Query: 239 DAEEIKRQNALYEI--EMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEK 296
D E + + ++++++++ + + H + ++ + ++ QE+ DE+
Sbjct: 267 DGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER 326
Query: 297 MRKFIKAKKRLIQMGKEKEAETH-----RLMEKRRERIHNFLSEL---LKEKLDNEDMII 348
+++ K K + M ++ + T L+E+ + ++E + E L+ ++ I
Sbjct: 327 LQELEKIKD--LHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEI 384
Query: 349 ARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAK--EQLLAV 406
A+ + + + E +++K K+E E + ++ EE +RK++A+ EQ+ +
Sbjct: 385 AQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTI 444
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAE 466
K + E + + + QEV D + + + + AK K E + R + L +
Sbjct: 445 EKTSE---EERISLQQELSRVKQEVVD--VMKKSSEEQIAKLQKLHEKELARKEQELTKK 499
Query: 467 ---KEKEFQDYAREVIE 480
+E+EFQ+ + +E
Sbjct: 500 LQTREREFQEQMKVALE 516
Score = 48.9 bits (115), Expect = 1e-05
Identities = 67/307 (21%), Positives = 128/307 (41%), Gaps = 44/307 (14%)
Query: 41 KVDLQQVTIIPHDEWKRIQ--DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYA 98
+V+++++T +++++Q +D + L + K + HL +++ + +
Sbjct: 1871 RVEMEELT----SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHN 1926
Query: 99 GMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
+ E KL ++ +++ E L + + ++ +++ K+Y + E++K
Sbjct: 1927 DL-EFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQED 1985
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDH 218
L L + EF + +++ E +K I KA + E E E
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLE------------- 2032
Query: 219 LKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRF---LEH 275
EE + KK EKD +++KR YE + L+ + EEM R LE
Sbjct: 2033 ----SHQEETNQLLKKIAEKD-DDLKRTAKRYE----EILDAREEEMTAKVRDLQTQLEE 2083
Query: 276 MQDKHIIKAVEQQQQEEEDE----KMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHN 331
+Q K+ K +EQ++ D +++ + K LI K KE E RE+IHN
Sbjct: 2084 LQKKYQQK-LEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF-------REQIHN 2135
Query: 332 FLSELLK 338
L K
Sbjct: 2136 LEDRLKK 2142
Score = 48.5 bits (114), Expect = 2e-05
Identities = 90/421 (21%), Positives = 174/421 (41%), Gaps = 54/421 (12%)
Query: 70 ACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEI------EAERQILD 123
A R E K+++ + EV + N + E+KL + + +EI E E+++ +
Sbjct: 1017 AVSRLETNQKEQIESLT-EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAE 1075
Query: 124 LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDK 183
L+++I G K+ E K+ + + E VK + L +K++ A + K
Sbjct: 1076 LKQKILLFGCEKE--EMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK 1133
Query: 184 KWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLK------QIKEHEEEEERRKKYEE 237
E+L++++ K+ KE E+ ++ +D K ++K +EE + K E
Sbjct: 1134 AHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHE 1193
Query: 238 KDAEEIKRQNALYEI---EMRKKLE---KKREEMHESRRRFLEHMQDKH---IIKAVEQQ 288
K + ++ ++ ++ E+ +L+ KK E + E++ L ++ I+ +
Sbjct: 1194 KSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHC 1253
Query: 289 QQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNF--LSELLKEKLDNEDM 346
Q K IK E EA+ +L E++ +F + L+EK +N+
Sbjct: 1254 QHRTTKVKEALLIKTCTV-----SELEAQLRQLTEEQNTLNISFQQATHQLEEK-ENQIK 1307
Query: 347 IIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAV 406
+ DI E E ++E + +A KE Q K E E + AV
Sbjct: 1308 SMKADIESLVTEKEALQKEGGNQQQAA------------SEKESCITQLKKELSENINAV 1355
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQA------KQAELDYCRLT 460
+ E KEKK + +++ D ++Q + K+A KQ + + C L
Sbjct: 1356 T----LMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELL 1411
Query: 461 E 461
+
Sbjct: 1412 D 1412
Score = 47.0 bits (110), Expect = 5e-05
Identities = 77/356 (21%), Positives = 149/356 (41%), Gaps = 32/356 (8%)
Query: 68 EAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEE 127
E C ER K L E +H + G +++LE K K+ I A+ +E+E
Sbjct: 1768 EMRCQYQERLIK----LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH----VEKE 1819
Query: 128 IYKQG-KRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKS--KIKSDKK 184
K + K+ +EN + Q + + +L + +KE D+ + +K +++ ++
Sbjct: 1820 GGKNNIQAKQNLENV--FDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEEL 1877
Query: 185 WEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEK--DAEE 242
+ KL + + E +K HL Q K E + E K AE
Sbjct: 1878 TSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER 1937
Query: 243 IKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIK 302
K++ + ++K L R+E H Q+ I+K Q++EE+ ++ ++ ++
Sbjct: 1938 EKQKLGKEIVRLQKDLRMLRKE----------HQQELEILKKEYDQEREEKIKQEQEDLE 1987
Query: 303 AKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKR 362
K +E T +L +K +E L +KE + N+ + ++ E+ E +
Sbjct: 1988 LKHNSTLKQLMREFNT-QLAQKEQE-----LEMTIKETI-NKAQEVEAELLESHQEETNQ 2040
Query: 363 EREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEK 418
+K + +LK A+ ++ +EEE + + + QL + K Q E E+
Sbjct: 2041 LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEE 2096
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 81.3 bits (199), Expect = 2e-15
Identities = 91/432 (21%), Positives = 195/432 (45%), Gaps = 29/432 (6%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAI 138
K E+ L + + +T ++ +LEA ++R E ER+ + EE + K ++
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 139 ENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFK 198
++ + ER+K R E+++ + + ++ + K+ + + K + +
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 199 EEQEKAEKRHRERVAL--AKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
+EQE + +E+ L + + + EE E + E++A + +RQ +E +
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-----VEEAE 2115
Query: 257 KLEKKREEMHESR---RRFLEHMQDKHIIKAVEQQQQEE-----------EDEKMRKFIK 302
+L++ EE ++R + E ++ + +A + Q E+ E EK +KF
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2173
Query: 303 AKKRLIQMGK-EKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEK 361
A++ L Q + E+E T RL + + N L E L ++L E AR ++ E E
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-QRLKAEATEAARQRSQVEEELFS 2232
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ +E +K + + AE RA+++++K+ +R + EA++ +A ++ ++ +
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 422 CKADKEHQEVQD-AHIQQMAKNKFNAKQAK---QAELDYCRLTEALVAEKEKEFQDYARE 477
+ E Q A ++M K K A Q +AE + + + L E+ + Q+ +
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 478 VIELESETTNKY 489
+ + +E T +
Sbjct: 2353 MAQQLAEETQGF 2364
Score = 80.9 bits (198), Expect = 3e-15
Identities = 90/438 (20%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
+AER+AK E+ R QE V ++QK + EE++ RQ E EI +
Sbjct: 1385 QAEREAK-ELQQRMQEEVVRREEAAVDAQQQK----RSIQEELQQLRQ--SSEAEIQAKA 1437
Query: 133 KRKKAIENAK----------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSK---- 178
++ +A E ++ + Q TER + G L + + +A+ + R+++
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 179 -----IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
++ + + + Q ++ + K E E A ++ R AL + L+ EE E R +
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA----EEAERRLR 1553
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
+ E + A +++ + +L+ KR E + +Q++H+ AV Q ++E
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE-- 1609
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
A++R Q + + A E+ ER +E L+ +L E++ + +A
Sbjct: 1610 ---------AERRAQQQAEAERAREEA--ERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 354 EAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEER-------QRKIEAKEQLLAV 406
+AEAE +K E E++ + + + + A + + + + E++R Q+++ A+++L+ +
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK-QAELDYCRLTEALVA 465
+ + E++++ ++ + ++A + + A+ AK +AE++ ++A
Sbjct: 1719 RAETE---QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Query: 466 EKEKEFQDYAREVIELES 483
E+ + + +++ +E E+
Sbjct: 1776 EESRSTSEKSKQRLEAEA 1793
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/586 (22%), Positives = 241/586 (41%), Gaps = 111/586 (18%)
Query: 4 SSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKV-------DLQQVTIIPHD--- 53
SSE ++ R A E + +R EE +V+ L L ++ +LQ + +
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQ-----EVVKHWTNTYAGMKEQKLEA- 107
+ ++ Q+ +RL R+ ++RK + E+ L S+ E + ++E +L+A
Sbjct: 1488 QKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 108 ---KKKRDEEIEAERQILDLEE------EIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
++ R E+E RQ+ E E Q KR E Q + ++ H
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVA 1602
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWE-EQLKLNIEKAFKEEQEKAEKRHRERVALAKD 217
+ R ER AQ + + + + + E E+ +L +A + + E ++ +A A+
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 218 HLKQIKEHEEEEERRKKYEEKDA-------EEIKRQNALYEIEMRKKLEKKRE------- 263
KQ +E E E RR K EE+ +E+++Q L E +++L ++E
Sbjct: 1663 E-KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721
Query: 264 -EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-EAETHRL 321
E E +R+ LE + +A Q+ +E E ++A+ ++ K + E E+
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 322 MEKRRERIH----------------NFLSELLKEKLDNEDMIIARDIAEAE--------- 356
EK ++R+ L+E K + + AR AEAE
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 357 --------AEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMK 408
E E +EK+ +N+ L+ +AE A + EE+ Q K + +E+L + K
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 409 ADQIFWEHEKE-----------------------KKCKADKEHQEVQDAHIQQMAKNKFN 445
A E +K +K A K E++ I+ A++
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 446 AKQAKQAELDYCRLTEALVAEKE---KEFQDYAREVIELESETTNK 488
+K+ QAEL+ R + L AE+E +E ++ ++ + E E +
Sbjct: 1961 SKE--QAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQ 2003
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/515 (20%), Positives = 212/515 (41%), Gaps = 58/515 (11%)
Query: 13 RRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACL 72
R+ A+E+ + R E++ + + +LQQ ++ Q LD+L EA
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL-------QQEQSVLDQLRGEAEAA 2086
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R + +E ++++ + K A+++ +A+ L +E ++
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 133 KRKKAIENA----KQYQFYQTERVKNFHSGLLLSRVMKERDA---QIEFRKSKIKSDKKW 185
R+ E A KQ + E+ K F L + E++ +++ ++ + +
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD------ 239
EE +L E Q + V + + L ++K E E R +KD
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 240 AEEIKRQNALYEIEMR--------KKLEKKREEMHESRRRFLEHMQDKHIIKAVE----- 286
EE ++ + E R +L + EE +R E M K ++AV+
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-KEKMQAVQEATRL 2325
Query: 287 -------QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKE 339
QQQ+E E+ R+ + K+++ Q E+ R +E R+R +E +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 340 KLDNEDMIIARDIAEAEAEWEKREREK--DEKNKAELKTIAEYRAIVMKNKEEEERQRKI 397
KL +M A+ AE +A+ +++ E+ ++ ++ EL T + + +++ E + +Q
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDH 2443
Query: 398 EAKEQLLAVMKADQIFWEHEKEKKCKADK----EHQEVQDAHIQQMAKNKFNAKQAKQAE 453
+A+ A+ + E EKEK + K + +E+Q +Q+ + +Q+ +E
Sbjct: 2444 DAERLREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 454 LDYC----RLTEALVAEKEKEFQDYAREVIELESE 484
D R E A+ E+ FQD + +L E
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Score = 65.5 bits (158), Expect = 1e-10
Identities = 115/509 (22%), Positives = 206/509 (40%), Gaps = 54/509 (10%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVT---IIPHDEWKRIQDSLDRLTREAACLR 73
RA+E E R E Q+ L ++ ++V + E ++ ++ +R R +
Sbjct: 1622 RAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG--K 1678
Query: 74 AERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKK----RDEEIEAERQILDLEEEIY 129
AE +A ++ L QE+ K G +Q+L A+++ R E + E+Q LEEE+
Sbjct: 1679 AEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
+ + A +Q + +V+ LL S+ E +++ KSK + + +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE---------EERRKKYE---- 236
+L E A + AE+ R+R +D +Q E E E R K E
Sbjct: 1798 ELAEEAA--RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 237 --EKDAE-EIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
EK+AE E R+ A E R++LE++ + L ++ + Q+ E+
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
+ R+ ++ + ++ EK A +E RI + + L+ K E +
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 354 EAEAEWEKREREK------------DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
AE E +RE E+ + KA L+ + +A V + + ER + A++
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
LA A + EK ++ QE+Q Q +Q+ LD R E
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ------------QTLQQEQSVLDQLR-GE 2082
Query: 462 ALVAEKEKEFQDYAREVIELESETTNKYI 490
A A + E + AR E E+ + + +
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Score = 60.5 bits (145), Expect = 4e-09
Identities = 59/346 (17%), Positives = 161/346 (46%), Gaps = 17/346 (4%)
Query: 60 DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER 119
+ + ++ EAA L + + ++E + M ++K++A ++ ++AE
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEA 2329
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK-ERDAQIEFRKSK 178
++L ++E+ ++ R+ E+ +Q E + F L R + E A+ E K +
Sbjct: 2330 ELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388
Query: 179 IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHR------ERVALAK--DHLKQIKEHEEEEE 230
+ + + + + + ++ K+ +E EK HR E+V L + + +Q +H+ E
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 231 RRKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R E E++ E+++++ L +++ + ++E++ + + + + ++
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIA 349
E+E K+ + + + Q +E++ + ME+ R+R+ + E + + + E+ +
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 350 RDIAEAEAEWEKRER-----EKDEKNKAELKTIAEYRAIVMKNKEE 390
+ + E ++R++ E++++ + +L+ + E + + EE
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 59.3 bits (142), Expect = 9e-09
Identities = 106/480 (22%), Positives = 202/480 (42%), Gaps = 50/480 (10%)
Query: 22 TEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKE 81
T++R E +Q L ++ + + P W +QD+ R + A A+ +A +E
Sbjct: 1195 TDVRQRELEQ------LGRQLRYYRESADPLGAW--LQDARRRQEQIQAMPLADSQAVRE 1246
Query: 82 MHLRSQ----EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
+ Q E+ +H + K +D E++ LE K K
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMK---ERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
+ Q Y R L S+ +K E ++E + ++ ++ EE+ +L
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQQRAEERERLAEV 1365
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR--QNALYEI 252
+A E+Q + + H + A A+ K++++ +EE R++ DA++ KR Q L ++
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 253 EMRKKLE-----KKREEMHESRRRFLEHMQDKHI-IKAVEQQQQEEEDEKMRKFIKAKKR 306
+ E ++ E SR R E ++ + ++A E+Q+ E E +
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE--------LQA 1477
Query: 307 LIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK 366
L +E EA+ + E+ ER+ + + + K E + +R AEAEA RE+++
Sbjct: 1478 LRARAEEAEAQKRQAQEE-AERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQR 1533
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC---- 422
+ EL+ AE E RQ ++E Q+ ++ Q E E + K
Sbjct: 1534 ALQALEELRLQAE-------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 423 -KADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
K + + +Q+ H+ +A+ + A++ Q + + R E E E+ +Q A E + L
Sbjct: 1587 EKTAQLERSLQEEHV-AVAQLREEAERRAQQQAEAERAREEAERELER-WQLKANEALRL 1644
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/284 (19%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 44 LQQVTIIPHDEWKRIQDSLDRLTREAA--------CLRAERKAKKEMHLRSQEV---VKH 92
LQQ + ++ +R+Q+ +++ ++ A L AER+ + EM ++ + V
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2391
Query: 93 WTNTYAGMKEQKLEAKKKRDE--------------------EIEAERQILD-----LEEE 127
+ A +E +K+ +E +E +RQ D L E
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
I + + K+ ++ + ++E ++ LL + + + + S ++ ++ + E
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIE 2510
Query: 188 QLKLNIEKAFKEEQEKAEK-------------RHRERVALAKDHLKQIKEHEEEEERRKK 234
Q K +E+ F++E KA++ + R+R+ + + ++ + EE RRK+
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
E + E+ +RQ E ++L ++ + + E R L H ++
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 31.2 bits (69), Expect = 2.6
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 52 HDEWKRIQDSLDRLTREAACLRAERKA----KKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD +R+++++ L RE L+ E K +EM QE + T + ++
Sbjct: 2443 HDA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 108 KKKRDEEIEAERQILD--LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
+R+ IE E+ L+ ++E+ K + ++ E +Q Q + ER + S R
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 166 KERDAQIEFRKSKIKSDKKW---------EEQLKLNIEKAFKEEQEKAEKRHRERVALAK 216
E + + ++ +++ ++ EE +L + EEQ +A H E V ++
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 81.3 bits (199), Expect = 2e-15
Identities = 91/432 (21%), Positives = 195/432 (45%), Gaps = 29/432 (6%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAI 138
K E+ L + + +T ++ +LEA ++R E ER+ + EE + K ++
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2004
Query: 139 ENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFK 198
++ + ER+K R E+++ + + ++ + K+ + + K + +
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 199 EEQEKAEKRHRERVAL--AKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
+EQE + +E+ L + + + EE E + E++A + +RQ +E +
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-----VEEAE 2119
Query: 257 KLEKKREEMHESR---RRFLEHMQDKHIIKAVEQQQQEE-----------EDEKMRKFIK 302
+L++ EE ++R + E ++ + +A + Q E+ E EK +KF
Sbjct: 2120 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2177
Query: 303 AKKRLIQMGK-EKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEK 361
A++ L Q + E+E T RL + + N L E L ++L E AR ++ E E
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-QRLKAEATEAARQRSQVEEELFS 2236
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ +E +K + + AE RA+++++K+ +R + EA++ +A ++ ++ +
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 422 CKADKEHQEVQD-AHIQQMAKNKFNAKQAK---QAELDYCRLTEALVAEKEKEFQDYARE 477
+ E Q A ++M K K A Q +AE + + + L E+ + Q+ +
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 478 VIELESETTNKY 489
+ + +E T +
Sbjct: 2357 MAQQLAEETQGF 2368
Score = 80.9 bits (198), Expect = 3e-15
Identities = 90/438 (20%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
+AER+AK E+ R QE V ++QK + EE++ RQ E EI +
Sbjct: 1389 QAEREAK-ELQQRMQEEVVRREEAAVDAQQQK----RSIQEELQQLRQ--SSEAEIQAKA 1441
Query: 133 KRKKAIENAK----------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSK---- 178
++ +A E ++ + Q TER + G L + + +A+ + R+++
Sbjct: 1442 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1501
Query: 179 -----IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
++ + + + Q ++ + K E E A ++ R AL + L+ EE E R +
Sbjct: 1502 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA----EEAERRLR 1557
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
+ E + A +++ + +L+ KR E + +Q++H+ AV Q ++E
Sbjct: 1558 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE-- 1613
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
A++R Q + + A E+ ER +E L+ +L E++ + +A
Sbjct: 1614 ---------AERRAQQQAEAERAREEA--ERELERWQLKANEALRLRLQAEEVAQQKSLA 1662
Query: 354 EAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEER-------QRKIEAKEQLLAV 406
+AEAE +K E E++ + + + + A + + + + E++R Q+++ A+++L+ +
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1722
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK-QAELDYCRLTEALVA 465
+ + E++++ ++ + ++A + + A+ AK +AE++ ++A
Sbjct: 1723 RAETE---QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779
Query: 466 EKEKEFQDYAREVIELES 483
E+ + + +++ +E E+
Sbjct: 1780 EESRSTSEKSKQRLEAEA 1797
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/586 (22%), Positives = 241/586 (41%), Gaps = 111/586 (18%)
Query: 4 SSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKV-------DLQQVTIIPHD--- 53
SSE ++ R A E + +R EE +V+ L L ++ +LQ + +
Sbjct: 1432 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1491
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQ-----EVVKHWTNTYAGMKEQKLEA- 107
+ ++ Q+ +RL R+ ++RK + E+ L S+ E + ++E +L+A
Sbjct: 1492 QKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1550
Query: 108 ---KKKRDEEIEAERQILDLEE------EIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
++ R E+E RQ+ E E Q KR E Q + ++ H
Sbjct: 1551 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVA 1606
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWE-EQLKLNIEKAFKEEQEKAEKRHRERVALAKD 217
+ R ER AQ + + + + + E E+ +L +A + + E ++ +A A+
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666
Query: 218 HLKQIKEHEEEEERRKKYEEKDA-------EEIKRQNALYEIEMRKKLEKKRE------- 263
KQ +E E E RR K EE+ +E+++Q L E +++L ++E
Sbjct: 1667 E-KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1725
Query: 264 -EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-EAETHRL 321
E E +R+ LE + +A Q+ +E E ++A+ ++ K + E E+
Sbjct: 1726 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1785
Query: 322 MEKRRERIH----------------NFLSELLKEKLDNEDMIIARDIAEAE--------- 356
EK ++R+ L+E K + + AR AEAE
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 357 --------AEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMK 408
E E +EK+ +N+ L+ +AE A + EE+ Q K + +E+L + K
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904
Query: 409 ADQIFWEHEKE-----------------------KKCKADKEHQEVQDAHIQQMAKNKFN 445
A E +K +K A K E++ I+ A++
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964
Query: 446 AKQAKQAELDYCRLTEALVAEKE---KEFQDYAREVIELESETTNK 488
+K+ QAEL+ R + L AE+E +E ++ ++ + E E +
Sbjct: 1965 SKE--QAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQ 2007
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/515 (20%), Positives = 212/515 (41%), Gaps = 58/515 (11%)
Query: 13 RRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACL 72
R+ A+E+ + R E++ + + +LQQ ++ Q LD+L EA
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL-------QQEQSVLDQLRGEAEAA 2090
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R + +E ++++ + K A+++ +A+ L +E ++
Sbjct: 2091 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 133 KRKKAIENA----KQYQFYQTERVKNFHSGLLLSRVMKERDA---QIEFRKSKIKSDKKW 185
R+ E A KQ + E+ K F L + E++ +++ ++ + +
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD------ 239
EE +L E Q + V + + L ++K E E R +KD
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270
Query: 240 AEEIKRQNALYEIEMR--------KKLEKKREEMHESRRRFLEHMQDKHIIKAVE----- 286
EE ++ + E R +L + EE +R E M K ++AV+
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-KEKMQAVQEATRL 2329
Query: 287 -------QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKE 339
QQQ+E E+ R+ + K+++ Q E+ R +E R+R +E +
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 340 KLDNEDMIIARDIAEAEAEWEKREREK--DEKNKAELKTIAEYRAIVMKNKEEEERQRKI 397
KL +M A+ AE +A+ +++ E+ ++ ++ EL T + + +++ E + +Q
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDH 2447
Query: 398 EAKEQLLAVMKADQIFWEHEKEKKCKADK----EHQEVQDAHIQQMAKNKFNAKQAKQAE 453
+A+ A+ + E EKEK + K + +E+Q +Q+ + +Q+ +E
Sbjct: 2448 DAERLREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502
Query: 454 LDYC----RLTEALVAEKEKEFQDYAREVIELESE 484
D R E A+ E+ FQD + +L E
Sbjct: 2503 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2537
Score = 65.5 bits (158), Expect = 1e-10
Identities = 115/509 (22%), Positives = 206/509 (40%), Gaps = 54/509 (10%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVT---IIPHDEWKRIQDSLDRLTREAACLR 73
RA+E E R E Q+ L ++ ++V + E ++ ++ +R R +
Sbjct: 1626 RAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG--K 1682
Query: 74 AERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKK----RDEEIEAERQILDLEEEIY 129
AE +A ++ L QE+ K G +Q+L A+++ R E + E+Q LEEE+
Sbjct: 1683 AEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
+ + A +Q + +V+ LL S+ E +++ KSK + + +
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE---------EERRKKYE---- 236
+L E A + AE+ R+R +D +Q E E E R K E
Sbjct: 1802 ELAEEAA--RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859
Query: 237 --EKDAE-EIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
EK+AE E R+ A E R++LE++ + L ++ + Q+ E+
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
+ R+ ++ + ++ EK A +E RI + + L+ K E +
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979
Query: 354 EAEAEWEKREREK------------DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
AE E +RE E+ + KA L+ + +A V + + ER + A++
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
LA A + EK ++ QE+Q Q +Q+ LD R E
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ------------QTLQQEQSVLDQLR-GE 2086
Query: 462 ALVAEKEKEFQDYAREVIELESETTNKYI 490
A A + E + AR E E+ + + +
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQV 2115
Score = 60.5 bits (145), Expect = 4e-09
Identities = 59/346 (17%), Positives = 161/346 (46%), Gaps = 17/346 (4%)
Query: 60 DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER 119
+ + ++ EAA L + + ++E + M ++K++A ++ ++AE
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEA 2333
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK-ERDAQIEFRKSK 178
++L ++E+ ++ R+ E+ +Q E + F L R + E A+ E K +
Sbjct: 2334 ELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2392
Query: 179 IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHR------ERVALAK--DHLKQIKEHEEEEE 230
+ + + + + + ++ K+ +E EK HR E+V L + + +Q +H+ E
Sbjct: 2393 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2452
Query: 231 RRKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R E E++ E+++++ L +++ + ++E++ + + + + ++
Sbjct: 2453 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIA 349
E+E K+ + + + Q +E++ + ME+ R+R+ + E + + + E+ +
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 350 RDIAEAEAEWEKRER-----EKDEKNKAELKTIAEYRAIVMKNKEE 390
+ + E ++R++ E++++ + +L+ + E + + EE
Sbjct: 2573 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618
Score = 59.3 bits (142), Expect = 9e-09
Identities = 106/480 (22%), Positives = 202/480 (42%), Gaps = 50/480 (10%)
Query: 22 TEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKE 81
T++R E +Q L ++ + + P W +QD+ R + A A+ +A +E
Sbjct: 1199 TDVRQRELEQ------LGRQLRYYRESADPLGAW--LQDARRRQEQIQAMPLADSQAVRE 1250
Query: 82 MHLRSQ----EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
+ Q E+ +H + K +D E++ LE K K
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1310
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMK---ERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
+ Q Y R L S+ +K E ++E + ++ ++ EE+ +L
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQQRAEERERLAEV 1369
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR--QNALYEI 252
+A E+Q + + H + A A+ K++++ +EE R++ DA++ KR Q L ++
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429
Query: 253 EMRKKLE-----KKREEMHESRRRFLEHMQDKHI-IKAVEQQQQEEEDEKMRKFIKAKKR 306
+ E ++ E SR R E ++ + ++A E+Q+ E E +
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE--------LQA 1481
Query: 307 LIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK 366
L +E EA+ + E+ ER+ + + + K E + +R AEAEA RE+++
Sbjct: 1482 LRARAEEAEAQKRQAQEE-AERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQR 1537
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC---- 422
+ EL+ AE E RQ ++E Q+ ++ Q E E + K
Sbjct: 1538 ALQALEELRLQAE-------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1590
Query: 423 -KADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
K + + +Q+ H+ +A+ + A++ Q + + R E E E+ +Q A E + L
Sbjct: 1591 EKTAQLERSLQEEHV-AVAQLREEAERRAQQQAEAERAREEAERELER-WQLKANEALRL 1648
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/284 (19%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 44 LQQVTIIPHDEWKRIQDSLDRLTREAA--------CLRAERKAKKEMHLRSQEV---VKH 92
LQQ + ++ +R+Q+ +++ ++ A L AER+ + EM ++ + V
Sbjct: 2336 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2395
Query: 93 WTNTYAGMKEQKLEAKKKRDE--------------------EIEAERQILD-----LEEE 127
+ A +E +K+ +E +E +RQ D L E
Sbjct: 2396 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2455
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
I + + K+ ++ + ++E ++ LL + + + + S ++ ++ + E
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIE 2514
Query: 188 QLKLNIEKAFKEEQEKAEK-------------RHRERVALAKDHLKQIKEHEEEEERRKK 234
Q K +E+ F++E KA++ + R+R+ + + ++ + EE RRK+
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
E + E+ +RQ E ++L ++ + + E R L H ++
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618
Score = 31.2 bits (69), Expect = 2.6
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 52 HDEWKRIQDSLDRLTREAACLRAERKA----KKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD +R+++++ L RE L+ E K +EM QE + T + ++
Sbjct: 2447 HDA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2505
Query: 108 KKKRDEEIEAERQILD--LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
+R+ IE E+ L+ ++E+ K + ++ E +Q Q + ER + S R
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQ 2563
Query: 166 KERDAQIEFRKSKIKSDKKW---------EEQLKLNIEKAFKEEQEKAEKRHRERVALAK 216
E + + ++ +++ ++ EE +L + EEQ +A H E V ++
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 81.3 bits (199), Expect = 2e-15
Identities = 91/432 (21%), Positives = 195/432 (45%), Gaps = 29/432 (6%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAI 138
K E+ L + + +T ++ +LEA ++R E ER+ + EE + K ++
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000
Query: 139 ENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFK 198
++ + ER+K R E+++ + + ++ + K+ + + K + +
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 199 EEQEKAEKRHRERVAL--AKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
+EQE + +E+ L + + + EE E + E++A + +RQ +E +
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-----VEEAE 2115
Query: 257 KLEKKREEMHESR---RRFLEHMQDKHIIKAVEQQQQEE-----------EDEKMRKFIK 302
+L++ EE ++R + E ++ + +A + Q E+ E EK +KF
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2173
Query: 303 AKKRLIQMGK-EKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEK 361
A++ L Q + E+E T RL + + N L E L ++L E AR ++ E E
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-QRLKAEATEAARQRSQVEEELFS 2232
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ +E +K + + AE RA+++++K+ +R + EA++ +A ++ ++ +
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 422 CKADKEHQEVQD-AHIQQMAKNKFNAKQAK---QAELDYCRLTEALVAEKEKEFQDYARE 477
+ E Q A ++M K K A Q +AE + + + L E+ + Q+ +
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 478 VIELESETTNKY 489
+ + +E T +
Sbjct: 2353 MAQQLAEETQGF 2364
Score = 80.9 bits (198), Expect = 3e-15
Identities = 90/438 (20%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
+AER+AK E+ R QE V ++QK + EE++ RQ E EI +
Sbjct: 1385 QAEREAK-ELQQRMQEEVVRREEAAVDAQQQK----RSIQEELQQLRQ--SSEAEIQAKA 1437
Query: 133 KRKKAIENAK----------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSK---- 178
++ +A E ++ + Q TER + G L + + +A+ + R+++
Sbjct: 1438 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1497
Query: 179 -----IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
++ + + + Q ++ + K E E A ++ R AL + L+ EE E R +
Sbjct: 1498 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA----EEAERRLR 1553
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
+ E + A +++ + +L+ KR E + +Q++H+ AV Q ++E
Sbjct: 1554 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE-- 1609
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
A++R Q + + A E+ ER +E L+ +L E++ + +A
Sbjct: 1610 ---------AERRAQQQAEAERAREEA--ERELERWQLKANEALRLRLQAEEVAQQKSLA 1658
Query: 354 EAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEER-------QRKIEAKEQLLAV 406
+AEAE +K E E++ + + + + A + + + + E++R Q+++ A+++L+ +
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1718
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK-QAELDYCRLTEALVA 465
+ + E++++ ++ + ++A + + A+ AK +AE++ ++A
Sbjct: 1719 RAETE---QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775
Query: 466 EKEKEFQDYAREVIELES 483
E+ + + +++ +E E+
Sbjct: 1776 EESRSTSEKSKQRLEAEA 1793
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/586 (22%), Positives = 241/586 (41%), Gaps = 111/586 (18%)
Query: 4 SSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKV-------DLQQVTIIPHD--- 53
SSE ++ R A E + +R EE +V+ L L ++ +LQ + +
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQ-----EVVKHWTNTYAGMKEQKLEA- 107
+ ++ Q+ +RL R+ ++RK + E+ L S+ E + ++E +L+A
Sbjct: 1488 QKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1546
Query: 108 ---KKKRDEEIEAERQILDLEE------EIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
++ R E+E RQ+ E E Q KR E Q + ++ H
Sbjct: 1547 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVA 1602
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWE-EQLKLNIEKAFKEEQEKAEKRHRERVALAKD 217
+ R ER AQ + + + + + E E+ +L +A + + E ++ +A A+
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662
Query: 218 HLKQIKEHEEEEERRKKYEEKDA-------EEIKRQNALYEIEMRKKLEKKRE------- 263
KQ +E E E RR K EE+ +E+++Q L E +++L ++E
Sbjct: 1663 E-KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1721
Query: 264 -EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-EAETHRL 321
E E +R+ LE + +A Q+ +E E ++A+ ++ K + E E+
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 322 MEKRRERIH----------------NFLSELLKEKLDNEDMIIARDIAEAE--------- 356
EK ++R+ L+E K + + AR AEAE
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 357 --------AEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMK 408
E E +EK+ +N+ L+ +AE A + EE+ Q K + +E+L + K
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 409 ADQIFWEHEKE-----------------------KKCKADKEHQEVQDAHIQQMAKNKFN 445
A E +K +K A K E++ I+ A++
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 446 AKQAKQAELDYCRLTEALVAEKE---KEFQDYAREVIELESETTNK 488
+K+ QAEL+ R + L AE+E +E ++ ++ + E E +
Sbjct: 1961 SKE--QAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQ 2003
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/515 (20%), Positives = 212/515 (41%), Gaps = 58/515 (11%)
Query: 13 RRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACL 72
R+ A+E+ + R E++ + + +LQQ ++ Q LD+L EA
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL-------QQEQSVLDQLRGEAEAA 2086
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R + +E ++++ + K A+++ +A+ L +E ++
Sbjct: 2087 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 133 KRKKAIENA----KQYQFYQTERVKNFHSGLLLSRVMKERDA---QIEFRKSKIKSDKKW 185
R+ E A KQ + E+ K F L + E++ +++ ++ + +
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD------ 239
EE +L E Q + V + + L ++K E E R +KD
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 240 AEEIKRQNALYEIEMR--------KKLEKKREEMHESRRRFLEHMQDKHIIKAVE----- 286
EE ++ + E R +L + EE +R E M K ++AV+
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-KEKMQAVQEATRL 2325
Query: 287 -------QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKE 339
QQQ+E E+ R+ + K+++ Q E+ R +E R+R +E +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 340 KLDNEDMIIARDIAEAEAEWEKREREK--DEKNKAELKTIAEYRAIVMKNKEEEERQRKI 397
KL +M A+ AE +A+ +++ E+ ++ ++ EL T + + +++ E + +Q
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDH 2443
Query: 398 EAKEQLLAVMKADQIFWEHEKEKKCKADK----EHQEVQDAHIQQMAKNKFNAKQAKQAE 453
+A+ A+ + E EKEK + K + +E+Q +Q+ + +Q+ +E
Sbjct: 2444 DAERLREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 454 LDYC----RLTEALVAEKEKEFQDYAREVIELESE 484
D R E A+ E+ FQD + +L E
Sbjct: 2499 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Score = 65.5 bits (158), Expect = 1e-10
Identities = 115/509 (22%), Positives = 206/509 (40%), Gaps = 54/509 (10%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVT---IIPHDEWKRIQDSLDRLTREAACLR 73
RA+E E R E Q+ L ++ ++V + E ++ ++ +R R +
Sbjct: 1622 RAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG--K 1678
Query: 74 AERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKK----RDEEIEAERQILDLEEEIY 129
AE +A ++ L QE+ K G +Q+L A+++ R E + E+Q LEEE+
Sbjct: 1679 AEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
+ + A +Q + +V+ LL S+ E +++ KSK + + +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE---------EERRKKYE---- 236
+L E A + AE+ R+R +D +Q E E E R K E
Sbjct: 1798 ELAEEAA--RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855
Query: 237 --EKDAE-EIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
EK+AE E R+ A E R++LE++ + L ++ + Q+ E+
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
+ R+ ++ + ++ EK A +E RI + + L+ K E +
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 354 EAEAEWEKREREK------------DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
AE E +RE E+ + KA L+ + +A V + + ER + A++
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
LA A + EK ++ QE+Q Q +Q+ LD R E
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ------------QTLQQEQSVLDQLR-GE 2082
Query: 462 ALVAEKEKEFQDYAREVIELESETTNKYI 490
A A + E + AR E E+ + + +
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Score = 60.5 bits (145), Expect = 4e-09
Identities = 59/346 (17%), Positives = 161/346 (46%), Gaps = 17/346 (4%)
Query: 60 DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER 119
+ + ++ EAA L + + ++E + M ++K++A ++ ++AE
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEA 2329
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK-ERDAQIEFRKSK 178
++L ++E+ ++ R+ E+ +Q E + F L R + E A+ E K +
Sbjct: 2330 ELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2388
Query: 179 IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHR------ERVALAK--DHLKQIKEHEEEEE 230
+ + + + + + ++ K+ +E EK HR E+V L + + +Q +H+ E
Sbjct: 2389 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2448
Query: 231 RRKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R E E++ E+++++ L +++ + ++E++ + + + + ++
Sbjct: 2449 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIA 349
E+E K+ + + + Q +E++ + ME+ R+R+ + E + + + E+ +
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 350 RDIAEAEAEWEKRER-----EKDEKNKAELKTIAEYRAIVMKNKEE 390
+ + E ++R++ E++++ + +L+ + E + + EE
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 59.3 bits (142), Expect = 9e-09
Identities = 106/480 (22%), Positives = 202/480 (42%), Gaps = 50/480 (10%)
Query: 22 TEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKE 81
T++R E +Q L ++ + + P W +QD+ R + A A+ +A +E
Sbjct: 1195 TDVRQRELEQ------LGRQLRYYRESADPLGAW--LQDARRRQEQIQAMPLADSQAVRE 1246
Query: 82 MHLRSQ----EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
+ Q E+ +H + K +D E++ LE K K
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMK---ERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
+ Q Y R L S+ +K E ++E + ++ ++ EE+ +L
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQQRAEERERLAEV 1365
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR--QNALYEI 252
+A E+Q + + H + A A+ K++++ +EE R++ DA++ KR Q L ++
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 253 EMRKKLE-----KKREEMHESRRRFLEHMQDKHI-IKAVEQQQQEEEDEKMRKFIKAKKR 306
+ E ++ E SR R E ++ + ++A E+Q+ E E +
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE--------LQA 1477
Query: 307 LIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK 366
L +E EA+ + E+ ER+ + + + K E + +R AEAEA RE+++
Sbjct: 1478 LRARAEEAEAQKRQAQEE-AERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQR 1533
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC---- 422
+ EL+ AE E RQ ++E Q+ ++ Q E E + K
Sbjct: 1534 ALQALEELRLQAE-------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 423 -KADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
K + + +Q+ H+ +A+ + A++ Q + + R E E E+ +Q A E + L
Sbjct: 1587 EKTAQLERSLQEEHV-AVAQLREEAERRAQQQAEAERAREEAERELER-WQLKANEALRL 1644
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/284 (19%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 44 LQQVTIIPHDEWKRIQDSLDRLTREAA--------CLRAERKAKKEMHLRSQEV---VKH 92
LQQ + ++ +R+Q+ +++ ++ A L AER+ + EM ++ + V
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2391
Query: 93 WTNTYAGMKEQKLEAKKKRDE--------------------EIEAERQILD-----LEEE 127
+ A +E +K+ +E +E +RQ D L E
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
I + + K+ ++ + ++E ++ LL + + + + S ++ ++ + E
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIE 2510
Query: 188 QLKLNIEKAFKEEQEKAEK-------------RHRERVALAKDHLKQIKEHEEEEERRKK 234
Q K +E+ F++E KA++ + R+R+ + + ++ + EE RRK+
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
E + E+ +RQ E ++L ++ + + E R L H ++
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 31.2 bits (69), Expect = 2.6
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 52 HDEWKRIQDSLDRLTREAACLRAERKA----KKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD +R+++++ L RE L+ E K +EM QE + T + ++
Sbjct: 2443 HDA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 108 KKKRDEEIEAERQILD--LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
+R+ IE E+ L+ ++E+ K + ++ E +Q Q + ER + S R
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 166 KERDAQIEFRKSKIKSDKKW---------EEQLKLNIEKAFKEEQEKAEKRHRERVALAK 216
E + + ++ +++ ++ EE +L + EEQ +A H E V ++
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 81.3 bits (199), Expect = 2e-15
Identities = 91/432 (21%), Positives = 195/432 (45%), Gaps = 29/432 (6%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAI 138
K E+ L + + +T ++ +LEA ++R E ER+ + EE + K ++
Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1968
Query: 139 ENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFK 198
++ + ER+K R E+++ + + ++ + K+ + + K + +
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028
Query: 199 EEQEKAEKRHRERVAL--AKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
+EQE + +E+ L + + + EE E + E++A + +RQ +E +
Sbjct: 2029 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-----VEEAE 2083
Query: 257 KLEKKREEMHESR---RRFLEHMQDKHIIKAVEQQQQEE-----------EDEKMRKFIK 302
+L++ EE ++R + E ++ + +A + Q E+ E EK +KF
Sbjct: 2084 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2141
Query: 303 AKKRLIQMGK-EKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEK 361
A++ L Q + E+E T RL + + N L E L ++L E AR ++ E E
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-QRLKAEATEAARQRSQVEEELFS 2200
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ +E +K + + AE RA+++++K+ +R + EA++ +A ++ ++ +
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260
Query: 422 CKADKEHQEVQD-AHIQQMAKNKFNAKQAK---QAELDYCRLTEALVAEKEKEFQDYARE 477
+ E Q A ++M K K A Q +AE + + + L E+ + Q+ +
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 478 VIELESETTNKY 489
+ + +E T +
Sbjct: 2321 MAQQLAEETQGF 2332
Score = 80.9 bits (198), Expect = 3e-15
Identities = 90/438 (20%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
+AER+AK E+ R QE V ++QK + EE++ RQ E EI +
Sbjct: 1353 QAEREAK-ELQQRMQEEVVRREEAAVDAQQQK----RSIQEELQQLRQ--SSEAEIQAKA 1405
Query: 133 KRKKAIENAK----------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSK---- 178
++ +A E ++ + Q TER + G L + + +A+ + R+++
Sbjct: 1406 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1465
Query: 179 -----IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
++ + + + Q ++ + K E E A ++ R AL + L+ EE E R +
Sbjct: 1466 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA----EEAERRLR 1521
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
+ E + A +++ + +L+ KR E + +Q++H+ AV Q ++E
Sbjct: 1522 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE-- 1577
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
A++R Q + + A E+ ER +E L+ +L E++ + +A
Sbjct: 1578 ---------AERRAQQQAEAERAREEA--ERELERWQLKANEALRLRLQAEEVAQQKSLA 1626
Query: 354 EAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEER-------QRKIEAKEQLLAV 406
+AEAE +K E E++ + + + + A + + + + E++R Q+++ A+++L+ +
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1686
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK-QAELDYCRLTEALVA 465
+ + E++++ ++ + ++A + + A+ AK +AE++ ++A
Sbjct: 1687 RAETE---QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743
Query: 466 EKEKEFQDYAREVIELES 483
E+ + + +++ +E E+
Sbjct: 1744 EESRSTSEKSKQRLEAEA 1761
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/586 (22%), Positives = 241/586 (41%), Gaps = 111/586 (18%)
Query: 4 SSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKV-------DLQQVTIIPHD--- 53
SSE ++ R A E + +R EE +V+ L L ++ +LQ + +
Sbjct: 1396 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1455
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQ-----EVVKHWTNTYAGMKEQKLEA- 107
+ ++ Q+ +RL R+ ++RK + E+ L S+ E + ++E +L+A
Sbjct: 1456 QKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1514
Query: 108 ---KKKRDEEIEAERQILDLEE------EIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
++ R E+E RQ+ E E Q KR E Q + ++ H
Sbjct: 1515 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVA 1570
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWE-EQLKLNIEKAFKEEQEKAEKRHRERVALAKD 217
+ R ER AQ + + + + + E E+ +L +A + + E ++ +A A+
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630
Query: 218 HLKQIKEHEEEEERRKKYEEKDA-------EEIKRQNALYEIEMRKKLEKKRE------- 263
KQ +E E E RR K EE+ +E+++Q L E +++L ++E
Sbjct: 1631 E-KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1689
Query: 264 -EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-EAETHRL 321
E E +R+ LE + +A Q+ +E E ++A+ ++ K + E E+
Sbjct: 1690 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1749
Query: 322 MEKRRERIH----------------NFLSELLKEKLDNEDMIIARDIAEAE--------- 356
EK ++R+ L+E K + + AR AEAE
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 357 --------AEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMK 408
E E +EK+ +N+ L+ +AE A + EE+ Q K + +E+L + K
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868
Query: 409 ADQIFWEHEKE-----------------------KKCKADKEHQEVQDAHIQQMAKNKFN 445
A E +K +K A K E++ I+ A++
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928
Query: 446 AKQAKQAELDYCRLTEALVAEKE---KEFQDYAREVIELESETTNK 488
+K+ QAEL+ R + L AE+E +E ++ ++ + E E +
Sbjct: 1929 SKE--QAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQ 1971
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/515 (20%), Positives = 212/515 (41%), Gaps = 58/515 (11%)
Query: 13 RRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACL 72
R+ A+E+ + R E++ + + +LQQ ++ Q LD+L EA
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL-------QQEQSVLDQLRGEAEAA 2054
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R + +E ++++ + K A+++ +A+ L +E ++
Sbjct: 2055 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 133 KRKKAIENA----KQYQFYQTERVKNFHSGLLLSRVMKERDA---QIEFRKSKIKSDKKW 185
R+ E A KQ + E+ K F L + E++ +++ ++ + +
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD------ 239
EE +L E Q + V + + L ++K E E R +KD
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234
Query: 240 AEEIKRQNALYEIEMR--------KKLEKKREEMHESRRRFLEHMQDKHIIKAVE----- 286
EE ++ + E R +L + EE +R E M K ++AV+
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-KEKMQAVQEATRL 2293
Query: 287 -------QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKE 339
QQQ+E E+ R+ + K+++ Q E+ R +E R+R +E +
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 340 KLDNEDMIIARDIAEAEAEWEKREREK--DEKNKAELKTIAEYRAIVMKNKEEEERQRKI 397
KL +M A+ AE +A+ +++ E+ ++ ++ EL T + + +++ E + +Q
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDH 2411
Query: 398 EAKEQLLAVMKADQIFWEHEKEKKCKADK----EHQEVQDAHIQQMAKNKFNAKQAKQAE 453
+A+ A+ + E EKEK + K + +E+Q +Q+ + +Q+ +E
Sbjct: 2412 DAERLREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466
Query: 454 LDYC----RLTEALVAEKEKEFQDYAREVIELESE 484
D R E A+ E+ FQD + +L E
Sbjct: 2467 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2501
Score = 65.5 bits (158), Expect = 1e-10
Identities = 115/509 (22%), Positives = 206/509 (40%), Gaps = 54/509 (10%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVT---IIPHDEWKRIQDSLDRLTREAACLR 73
RA+E E R E Q+ L ++ ++V + E ++ ++ +R R +
Sbjct: 1590 RAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG--K 1646
Query: 74 AERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKK----RDEEIEAERQILDLEEEIY 129
AE +A ++ L QE+ K G +Q+L A+++ R E + E+Q LEEE+
Sbjct: 1647 AEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
+ + A +Q + +V+ LL S+ E +++ KSK + + +
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE---------EERRKKYE---- 236
+L E A + AE+ R+R +D +Q E E E R K E
Sbjct: 1766 ELAEEAA--RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823
Query: 237 --EKDAE-EIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
EK+AE E R+ A E R++LE++ + L ++ + Q+ E+
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
+ R+ ++ + ++ EK A +E RI + + L+ K E +
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943
Query: 354 EAEAEWEKREREK------------DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
AE E +RE E+ + KA L+ + +A V + + ER + A++
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2003
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
LA A + EK ++ QE+Q Q +Q+ LD R E
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ------------QTLQQEQSVLDQLR-GE 2050
Query: 462 ALVAEKEKEFQDYAREVIELESETTNKYI 490
A A + E + AR E E+ + + +
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQV 2079
Score = 60.5 bits (145), Expect = 4e-09
Identities = 59/346 (17%), Positives = 161/346 (46%), Gaps = 17/346 (4%)
Query: 60 DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER 119
+ + ++ EAA L + + ++E + M ++K++A ++ ++AE
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEA 2297
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK-ERDAQIEFRKSK 178
++L ++E+ ++ R+ E+ +Q E + F L R + E A+ E K +
Sbjct: 2298 ELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2356
Query: 179 IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHR------ERVALAK--DHLKQIKEHEEEEE 230
+ + + + + + ++ K+ +E EK HR E+V L + + +Q +H+ E
Sbjct: 2357 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2416
Query: 231 RRKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R E E++ E+++++ L +++ + ++E++ + + + + ++
Sbjct: 2417 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIA 349
E+E K+ + + + Q +E++ + ME+ R+R+ + E + + + E+ +
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 350 RDIAEAEAEWEKRER-----EKDEKNKAELKTIAEYRAIVMKNKEE 390
+ + E ++R++ E++++ + +L+ + E + + EE
Sbjct: 2537 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582
Score = 59.3 bits (142), Expect = 9e-09
Identities = 106/480 (22%), Positives = 202/480 (42%), Gaps = 50/480 (10%)
Query: 22 TEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKE 81
T++R E +Q L ++ + + P W +QD+ R + A A+ +A +E
Sbjct: 1163 TDVRQRELEQ------LGRQLRYYRESADPLGAW--LQDARRRQEQIQAMPLADSQAVRE 1214
Query: 82 MHLRSQ----EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
+ Q E+ +H + K +D E++ LE K K
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1274
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMK---ERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
+ Q Y R L S+ +K E ++E + ++ ++ EE+ +L
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQQRAEERERLAEV 1333
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR--QNALYEI 252
+A E+Q + + H + A A+ K++++ +EE R++ DA++ KR Q L ++
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393
Query: 253 EMRKKLE-----KKREEMHESRRRFLEHMQDKHI-IKAVEQQQQEEEDEKMRKFIKAKKR 306
+ E ++ E SR R E ++ + ++A E+Q+ E E +
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE--------LQA 1445
Query: 307 LIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK 366
L +E EA+ + E+ ER+ + + + K E + +R AEAEA RE+++
Sbjct: 1446 LRARAEEAEAQKRQAQEE-AERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQR 1501
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC---- 422
+ EL+ AE E RQ ++E Q+ ++ Q E E + K
Sbjct: 1502 ALQALEELRLQAE-------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1554
Query: 423 -KADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
K + + +Q+ H+ +A+ + A++ Q + + R E E E+ +Q A E + L
Sbjct: 1555 EKTAQLERSLQEEHV-AVAQLREEAERRAQQQAEAERAREEAERELER-WQLKANEALRL 1612
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/284 (19%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 44 LQQVTIIPHDEWKRIQDSLDRLTREAA--------CLRAERKAKKEMHLRSQEV---VKH 92
LQQ + ++ +R+Q+ +++ ++ A L AER+ + EM ++ + V
Sbjct: 2300 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2359
Query: 93 WTNTYAGMKEQKLEAKKKRDE--------------------EIEAERQILD-----LEEE 127
+ A +E +K+ +E +E +RQ D L E
Sbjct: 2360 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2419
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
I + + K+ ++ + ++E ++ LL + + + + S ++ ++ + E
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIE 2478
Query: 188 QLKLNIEKAFKEEQEKAEK-------------RHRERVALAKDHLKQIKEHEEEEERRKK 234
Q K +E+ F++E KA++ + R+R+ + + ++ + EE RRK+
Sbjct: 2479 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
E + E+ +RQ E ++L ++ + + E R L H ++
Sbjct: 2539 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582
Score = 31.2 bits (69), Expect = 2.6
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 52 HDEWKRIQDSLDRLTREAACLRAERKA----KKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD +R+++++ L RE L+ E K +EM QE + T + ++
Sbjct: 2411 HDA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2469
Query: 108 KKKRDEEIEAERQILD--LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
+R+ IE E+ L+ ++E+ K + ++ E +Q Q + ER + S R
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQ 2527
Query: 166 KERDAQIEFRKSKIKSDKKW---------EEQLKLNIEKAFKEEQEKAEKRHRERVALAK 216
E + + ++ +++ ++ EE +L + EEQ +A H E V ++
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 81.3 bits (199), Expect = 2e-15
Identities = 91/432 (21%), Positives = 195/432 (45%), Gaps = 29/432 (6%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAI 138
K E+ L + + +T ++ +LEA ++R E ER+ + EE + K ++
Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2137
Query: 139 ENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFK 198
++ + ER+K R E+++ + + ++ + K+ + + K + +
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197
Query: 199 EEQEKAEKRHRERVAL--AKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
+EQE + +E+ L + + + EE E + E++A + +RQ +E +
Sbjct: 2198 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-----VEEAE 2252
Query: 257 KLEKKREEMHESR---RRFLEHMQDKHIIKAVEQQQQEE-----------EDEKMRKFIK 302
+L++ EE ++R + E ++ + +A + Q E+ E EK +KF
Sbjct: 2253 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2310
Query: 303 AKKRLIQMGK-EKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEK 361
A++ L Q + E+E T RL + + N L E L ++L E AR ++ E E
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-QRLKAEATEAARQRSQVEEELFS 2369
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ +E +K + + AE RA+++++K+ +R + EA++ +A ++ ++ +
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429
Query: 422 CKADKEHQEVQD-AHIQQMAKNKFNAKQAK---QAELDYCRLTEALVAEKEKEFQDYARE 477
+ E Q A ++M K K A Q +AE + + + L E+ + Q+ +
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Query: 478 VIELESETTNKY 489
+ + +E T +
Sbjct: 2490 MAQQLAEETQGF 2501
Score = 80.9 bits (198), Expect = 3e-15
Identities = 90/438 (20%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
+AER+AK E+ R QE V ++QK + EE++ RQ E EI +
Sbjct: 1522 QAEREAK-ELQQRMQEEVVRREEAAVDAQQQK----RSIQEELQQLRQ--SSEAEIQAKA 1574
Query: 133 KRKKAIENAK----------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSK---- 178
++ +A E ++ + Q TER + G L + + +A+ + R+++
Sbjct: 1575 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1634
Query: 179 -----IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
++ + + + Q ++ + K E E A ++ R AL + L+ EE E R +
Sbjct: 1635 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA----EEAERRLR 1690
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
+ E + A +++ + +L+ KR E + +Q++H+ AV Q ++E
Sbjct: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE-- 1746
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
A++R Q + + A E+ ER +E L+ +L E++ + +A
Sbjct: 1747 ---------AERRAQQQAEAERAREEA--ERELERWQLKANEALRLRLQAEEVAQQKSLA 1795
Query: 354 EAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEER-------QRKIEAKEQLLAV 406
+AEAE +K E E++ + + + + A + + + + E++R Q+++ A+++L+ +
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1855
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK-QAELDYCRLTEALVA 465
+ + E++++ ++ + ++A + + A+ AK +AE++ ++A
Sbjct: 1856 RAETE---QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912
Query: 466 EKEKEFQDYAREVIELES 483
E+ + + +++ +E E+
Sbjct: 1913 EESRSTSEKSKQRLEAEA 1930
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/586 (22%), Positives = 241/586 (41%), Gaps = 111/586 (18%)
Query: 4 SSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKV-------DLQQVTIIPHD--- 53
SSE ++ R A E + +R EE +V+ L L ++ +LQ + +
Sbjct: 1565 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1624
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQ-----EVVKHWTNTYAGMKEQKLEA- 107
+ ++ Q+ +RL R+ ++RK + E+ L S+ E + ++E +L+A
Sbjct: 1625 QKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683
Query: 108 ---KKKRDEEIEAERQILDLEE------EIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
++ R E+E RQ+ E E Q KR E Q + ++ H
Sbjct: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVA 1739
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWE-EQLKLNIEKAFKEEQEKAEKRHRERVALAKD 217
+ R ER AQ + + + + + E E+ +L +A + + E ++ +A A+
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799
Query: 218 HLKQIKEHEEEEERRKKYEEKDA-------EEIKRQNALYEIEMRKKLEKKRE------- 263
KQ +E E E RR K EE+ +E+++Q L E +++L ++E
Sbjct: 1800 E-KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1858
Query: 264 -EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-EAETHRL 321
E E +R+ LE + +A Q+ +E E ++A+ ++ K + E E+
Sbjct: 1859 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1918
Query: 322 MEKRRERIH----------------NFLSELLKEKLDNEDMIIARDIAEAE--------- 356
EK ++R+ L+E K + + AR AEAE
Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978
Query: 357 --------AEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMK 408
E E +EK+ +N+ L+ +AE A + EE+ Q K + +E+L + K
Sbjct: 1979 IGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037
Query: 409 ADQIFWEHEKE-----------------------KKCKADKEHQEVQDAHIQQMAKNKFN 445
A E +K +K A K E++ I+ A++
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097
Query: 446 AKQAKQAELDYCRLTEALVAEKE---KEFQDYAREVIELESETTNK 488
+K+ QAEL+ R + L AE+E +E ++ ++ + E E +
Sbjct: 2098 SKE--QAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQ 2140
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/515 (20%), Positives = 212/515 (41%), Gaps = 58/515 (11%)
Query: 13 RRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACL 72
R+ A+E+ + R E++ + + +LQQ ++ Q LD+L EA
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL-------QQEQSVLDQLRGEAEAA 2223
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R + +E ++++ + K A+++ +A+ L +E ++
Sbjct: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 133 KRKKAIENA----KQYQFYQTERVKNFHSGLLLSRVMKERDA---QIEFRKSKIKSDKKW 185
R+ E A KQ + E+ K F L + E++ +++ ++ + +
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD------ 239
EE +L E Q + V + + L ++K E E R +KD
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403
Query: 240 AEEIKRQNALYEIEMR--------KKLEKKREEMHESRRRFLEHMQDKHIIKAVE----- 286
EE ++ + E R +L + EE +R E M K ++AV+
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-KEKMQAVQEATRL 2462
Query: 287 -------QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKE 339
QQQ+E E+ R+ + K+++ Q E+ R +E R+R +E +
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 340 KLDNEDMIIARDIAEAEAEWEKREREK--DEKNKAELKTIAEYRAIVMKNKEEEERQRKI 397
KL +M A+ AE +A+ +++ E+ ++ ++ EL T + + +++ E + +Q
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDH 2580
Query: 398 EAKEQLLAVMKADQIFWEHEKEKKCKADK----EHQEVQDAHIQQMAKNKFNAKQAKQAE 453
+A+ A+ + E EKEK + K + +E+Q +Q+ + +Q+ +E
Sbjct: 2581 DAERLREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635
Query: 454 LDYC----RLTEALVAEKEKEFQDYAREVIELESE 484
D R E A+ E+ FQD + +L E
Sbjct: 2636 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2670
Score = 65.5 bits (158), Expect = 1e-10
Identities = 115/509 (22%), Positives = 206/509 (40%), Gaps = 54/509 (10%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVT---IIPHDEWKRIQDSLDRLTREAACLR 73
RA+E E R E Q+ L ++ ++V + E ++ ++ +R R +
Sbjct: 1759 RAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG--K 1815
Query: 74 AERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKK----RDEEIEAERQILDLEEEIY 129
AE +A ++ L QE+ K G +Q+L A+++ R E + E+Q LEEE+
Sbjct: 1816 AEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
+ + A +Q + +V+ LL S+ E +++ KSK + + +
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE---------EERRKKYE---- 236
+L E A + AE+ R+R +D +Q E E E R K E
Sbjct: 1935 ELAEEAA--RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992
Query: 237 --EKDAE-EIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
EK+AE E R+ A E R++LE++ + L ++ + Q+ E+
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
+ R+ ++ + ++ EK A +E RI + + L+ K E +
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112
Query: 354 EAEAEWEKREREK------------DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
AE E +RE E+ + KA L+ + +A V + + ER + A++
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2172
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
LA A + EK ++ QE+Q Q +Q+ LD R E
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ------------QTLQQEQSVLDQLR-GE 2219
Query: 462 ALVAEKEKEFQDYAREVIELESETTNKYI 490
A A + E + AR E E+ + + +
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQV 2248
Score = 60.5 bits (145), Expect = 4e-09
Identities = 59/346 (17%), Positives = 161/346 (46%), Gaps = 17/346 (4%)
Query: 60 DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER 119
+ + ++ EAA L + + ++E + M ++K++A ++ ++AE
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEA 2466
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK-ERDAQIEFRKSK 178
++L ++E+ ++ R+ E+ +Q E + F L R + E A+ E K +
Sbjct: 2467 ELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525
Query: 179 IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHR------ERVALAK--DHLKQIKEHEEEEE 230
+ + + + + + ++ K+ +E EK HR E+V L + + +Q +H+ E
Sbjct: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585
Query: 231 RRKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R E E++ E+++++ L +++ + ++E++ + + + + ++
Sbjct: 2586 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIA 349
E+E K+ + + + Q +E++ + ME+ R+R+ + E + + + E+ +
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 350 RDIAEAEAEWEKRER-----EKDEKNKAELKTIAEYRAIVMKNKEE 390
+ + E ++R++ E++++ + +L+ + E + + EE
Sbjct: 2706 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751
Score = 59.3 bits (142), Expect = 9e-09
Identities = 106/480 (22%), Positives = 202/480 (42%), Gaps = 50/480 (10%)
Query: 22 TEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKE 81
T++R E +Q L ++ + + P W +QD+ R + A A+ +A +E
Sbjct: 1332 TDVRQRELEQ------LGRQLRYYRESADPLGAW--LQDARRRQEQIQAMPLADSQAVRE 1383
Query: 82 MHLRSQ----EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
+ Q E+ +H + K +D E++ LE K K
Sbjct: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMK---ERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
+ Q Y R L S+ +K E ++E + ++ ++ EE+ +L
Sbjct: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQQRAEERERLAEV 1502
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR--QNALYEI 252
+A E+Q + + H + A A+ K++++ +EE R++ DA++ KR Q L ++
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562
Query: 253 EMRKKLE-----KKREEMHESRRRFLEHMQDKHI-IKAVEQQQQEEEDEKMRKFIKAKKR 306
+ E ++ E SR R E ++ + ++A E+Q+ E E +
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE--------LQA 1614
Query: 307 LIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK 366
L +E EA+ + E+ ER+ + + + K E + +R AEAEA RE+++
Sbjct: 1615 LRARAEEAEAQKRQAQEE-AERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQR 1670
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC---- 422
+ EL+ AE E RQ ++E Q+ ++ Q E E + K
Sbjct: 1671 ALQALEELRLQAE-------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1723
Query: 423 -KADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
K + + +Q+ H+ +A+ + A++ Q + + R E E E+ +Q A E + L
Sbjct: 1724 EKTAQLERSLQEEHV-AVAQLREEAERRAQQQAEAERAREEAERELER-WQLKANEALRL 1781
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/284 (19%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 44 LQQVTIIPHDEWKRIQDSLDRLTREAA--------CLRAERKAKKEMHLRSQEV---VKH 92
LQQ + ++ +R+Q+ +++ ++ A L AER+ + EM ++ + V
Sbjct: 2469 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2528
Query: 93 WTNTYAGMKEQKLEAKKKRDE--------------------EIEAERQILD-----LEEE 127
+ A +E +K+ +E +E +RQ D L E
Sbjct: 2529 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2588
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
I + + K+ ++ + ++E ++ LL + + + + S ++ ++ + E
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIE 2647
Query: 188 QLKLNIEKAFKEEQEKAEK-------------RHRERVALAKDHLKQIKEHEEEEERRKK 234
Q K +E+ F++E KA++ + R+R+ + + ++ + EE RRK+
Sbjct: 2648 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
E + E+ +RQ E ++L ++ + + E R L H ++
Sbjct: 2708 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751
Score = 31.2 bits (69), Expect = 2.6
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 52 HDEWKRIQDSLDRLTREAACLRAERKA----KKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD +R+++++ L RE L+ E K +EM QE + T + ++
Sbjct: 2580 HDA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2638
Query: 108 KKKRDEEIEAERQILD--LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
+R+ IE E+ L+ ++E+ K + ++ E +Q Q + ER + S R
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQ 2696
Query: 166 KERDAQIEFRKSKIKSDKKW---------EEQLKLNIEKAFKEEQEKAEKRHRERVALAK 216
E + + ++ +++ ++ EE +L + EEQ +A H E V ++
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 81.3 bits (199), Expect = 2e-15
Identities = 91/432 (21%), Positives = 195/432 (45%), Gaps = 29/432 (6%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAI 138
K E+ L + + +T ++ +LEA ++R E ER+ + EE + K ++
Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1978
Query: 139 ENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFK 198
++ + ER+K R E+++ + + ++ + K+ + + K + +
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038
Query: 199 EEQEKAEKRHRERVAL--AKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
+EQE + +E+ L + + + EE E + E++A + +RQ +E +
Sbjct: 2039 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-----VEEAE 2093
Query: 257 KLEKKREEMHESR---RRFLEHMQDKHIIKAVEQQQQEE-----------EDEKMRKFIK 302
+L++ EE ++R + E ++ + +A + Q E+ E EK +KF
Sbjct: 2094 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2151
Query: 303 AKKRLIQMGK-EKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEK 361
A++ L Q + E+E T RL + + N L E L ++L E AR ++ E E
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-QRLKAEATEAARQRSQVEEELFS 2210
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ +E +K + + AE RA+++++K+ +R + EA++ +A ++ ++ +
Sbjct: 2211 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270
Query: 422 CKADKEHQEVQD-AHIQQMAKNKFNAKQAK---QAELDYCRLTEALVAEKEKEFQDYARE 477
+ E Q A ++M K K A Q +AE + + + L E+ + Q+ +
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Query: 478 VIELESETTNKY 489
+ + +E T +
Sbjct: 2331 MAQQLAEETQGF 2342
Score = 80.9 bits (198), Expect = 3e-15
Identities = 90/438 (20%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
+AER+AK E+ R QE V ++QK + EE++ RQ E EI +
Sbjct: 1363 QAEREAK-ELQQRMQEEVVRREEAAVDAQQQK----RSIQEELQQLRQ--SSEAEIQAKA 1415
Query: 133 KRKKAIENAK----------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSK---- 178
++ +A E ++ + Q TER + G L + + +A+ + R+++
Sbjct: 1416 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1475
Query: 179 -----IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
++ + + + Q ++ + K E E A ++ R AL + L+ EE E R +
Sbjct: 1476 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA----EEAERRLR 1531
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
+ E + A +++ + +L+ KR E + +Q++H+ AV Q ++E
Sbjct: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE-- 1587
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
A++R Q + + A E+ ER +E L+ +L E++ + +A
Sbjct: 1588 ---------AERRAQQQAEAERAREEA--ERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
Query: 354 EAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEER-------QRKIEAKEQLLAV 406
+AEAE +K E E++ + + + + A + + + + E++R Q+++ A+++L+ +
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1696
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK-QAELDYCRLTEALVA 465
+ + E++++ ++ + ++A + + A+ AK +AE++ ++A
Sbjct: 1697 RAETE---QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753
Query: 466 EKEKEFQDYAREVIELES 483
E+ + + +++ +E E+
Sbjct: 1754 EESRSTSEKSKQRLEAEA 1771
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/586 (22%), Positives = 241/586 (41%), Gaps = 111/586 (18%)
Query: 4 SSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKV-------DLQQVTIIPHD--- 53
SSE ++ R A E + +R EE +V+ L L ++ +LQ + +
Sbjct: 1406 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1465
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQ-----EVVKHWTNTYAGMKEQKLEA- 107
+ ++ Q+ +RL R+ ++RK + E+ L S+ E + ++E +L+A
Sbjct: 1466 QKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1524
Query: 108 ---KKKRDEEIEAERQILDLEE------EIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
++ R E+E RQ+ E E Q KR E Q + ++ H
Sbjct: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVA 1580
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWE-EQLKLNIEKAFKEEQEKAEKRHRERVALAKD 217
+ R ER AQ + + + + + E E+ +L +A + + E ++ +A A+
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640
Query: 218 HLKQIKEHEEEEERRKKYEEKDA-------EEIKRQNALYEIEMRKKLEKKRE------- 263
KQ +E E E RR K EE+ +E+++Q L E +++L ++E
Sbjct: 1641 E-KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1699
Query: 264 -EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-EAETHRL 321
E E +R+ LE + +A Q+ +E E ++A+ ++ K + E E+
Sbjct: 1700 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1759
Query: 322 MEKRRERIH----------------NFLSELLKEKLDNEDMIIARDIAEAE--------- 356
EK ++R+ L+E K + + AR AEAE
Sbjct: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
Query: 357 --------AEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMK 408
E E +EK+ +N+ L+ +AE A + EE+ Q K + +E+L + K
Sbjct: 1820 IGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
Query: 409 ADQIFWEHEKE-----------------------KKCKADKEHQEVQDAHIQQMAKNKFN 445
A E +K +K A K E++ I+ A++
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938
Query: 446 AKQAKQAELDYCRLTEALVAEKE---KEFQDYAREVIELESETTNK 488
+K+ QAEL+ R + L AE+E +E ++ ++ + E E +
Sbjct: 1939 SKE--QAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQ 1981
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/515 (20%), Positives = 212/515 (41%), Gaps = 58/515 (11%)
Query: 13 RRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACL 72
R+ A+E+ + R E++ + + +LQQ ++ Q LD+L EA
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL-------QQEQSVLDQLRGEAEAA 2064
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R + +E ++++ + K A+++ +A+ L +E ++
Sbjct: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 133 KRKKAIENA----KQYQFYQTERVKNFHSGLLLSRVMKERDA---QIEFRKSKIKSDKKW 185
R+ E A KQ + E+ K F L + E++ +++ ++ + +
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD------ 239
EE +L E Q + V + + L ++K E E R +KD
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244
Query: 240 AEEIKRQNALYEIEMR--------KKLEKKREEMHESRRRFLEHMQDKHIIKAVE----- 286
EE ++ + E R +L + EE +R E M K ++AV+
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-KEKMQAVQEATRL 2303
Query: 287 -------QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKE 339
QQQ+E E+ R+ + K+++ Q E+ R +E R+R +E +
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363
Query: 340 KLDNEDMIIARDIAEAEAEWEKREREK--DEKNKAELKTIAEYRAIVMKNKEEEERQRKI 397
KL +M A+ AE +A+ +++ E+ ++ ++ EL T + + +++ E + +Q
Sbjct: 2364 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDH 2421
Query: 398 EAKEQLLAVMKADQIFWEHEKEKKCKADK----EHQEVQDAHIQQMAKNKFNAKQAKQAE 453
+A+ A+ + E EKEK + K + +E+Q +Q+ + +Q+ +E
Sbjct: 2422 DAERLREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476
Query: 454 LDYC----RLTEALVAEKEKEFQDYAREVIELESE 484
D R E A+ E+ FQD + +L E
Sbjct: 2477 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2511
Score = 65.5 bits (158), Expect = 1e-10
Identities = 115/509 (22%), Positives = 206/509 (40%), Gaps = 54/509 (10%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVT---IIPHDEWKRIQDSLDRLTREAACLR 73
RA+E E R E Q+ L ++ ++V + E ++ ++ +R R +
Sbjct: 1600 RAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG--K 1656
Query: 74 AERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKK----RDEEIEAERQILDLEEEIY 129
AE +A ++ L QE+ K G +Q+L A+++ R E + E+Q LEEE+
Sbjct: 1657 AEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
+ + A +Q + +V+ LL S+ E +++ KSK + + +
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE---------EERRKKYE---- 236
+L E A + AE+ R+R +D +Q E E E R K E
Sbjct: 1776 ELAEEAA--RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833
Query: 237 --EKDAE-EIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
EK+AE E R+ A E R++LE++ + L ++ + Q+ E+
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
+ R+ ++ + ++ EK A +E RI + + L+ K E +
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953
Query: 354 EAEAEWEKREREK------------DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
AE E +RE E+ + KA L+ + +A V + + ER + A++
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
LA A + EK ++ QE+Q Q +Q+ LD R E
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ------------QTLQQEQSVLDQLR-GE 2060
Query: 462 ALVAEKEKEFQDYAREVIELESETTNKYI 490
A A + E + AR E E+ + + +
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQV 2089
Score = 60.5 bits (145), Expect = 4e-09
Identities = 59/346 (17%), Positives = 161/346 (46%), Gaps = 17/346 (4%)
Query: 60 DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER 119
+ + ++ EAA L + + ++E + M ++K++A ++ ++AE
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEA 2307
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK-ERDAQIEFRKSK 178
++L ++E+ ++ R+ E+ +Q E + F L R + E A+ E K +
Sbjct: 2308 ELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
Query: 179 IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHR------ERVALAK--DHLKQIKEHEEEEE 230
+ + + + + + ++ K+ +E EK HR E+V L + + +Q +H+ E
Sbjct: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
Query: 231 RRKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R E E++ E+++++ L +++ + ++E++ + + + + ++
Sbjct: 2427 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2486
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIA 349
E+E K+ + + + Q +E++ + ME+ R+R+ + E + + + E+ +
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546
Query: 350 RDIAEAEAEWEKRER-----EKDEKNKAELKTIAEYRAIVMKNKEE 390
+ + E ++R++ E++++ + +L+ + E + + EE
Sbjct: 2547 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
Score = 59.3 bits (142), Expect = 9e-09
Identities = 106/480 (22%), Positives = 202/480 (42%), Gaps = 50/480 (10%)
Query: 22 TEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKE 81
T++R E +Q L ++ + + P W +QD+ R + A A+ +A +E
Sbjct: 1173 TDVRQRELEQ------LGRQLRYYRESADPLGAW--LQDARRRQEQIQAMPLADSQAVRE 1224
Query: 82 MHLRSQ----EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
+ Q E+ +H + K +D E++ LE K K
Sbjct: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMK---ERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
+ Q Y R L S+ +K E ++E + ++ ++ EE+ +L
Sbjct: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQQRAEERERLAEV 1343
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR--QNALYEI 252
+A E+Q + + H + A A+ K++++ +EE R++ DA++ KR Q L ++
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
Query: 253 EMRKKLE-----KKREEMHESRRRFLEHMQDKHI-IKAVEQQQQEEEDEKMRKFIKAKKR 306
+ E ++ E SR R E ++ + ++A E+Q+ E E +
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE--------LQA 1455
Query: 307 LIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK 366
L +E EA+ + E+ ER+ + + + K E + +R AEAEA RE+++
Sbjct: 1456 LRARAEEAEAQKRQAQEE-AERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQR 1511
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC---- 422
+ EL+ AE E RQ ++E Q+ ++ Q E E + K
Sbjct: 1512 ALQALEELRLQAE-------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1564
Query: 423 -KADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
K + + +Q+ H+ +A+ + A++ Q + + R E E E+ +Q A E + L
Sbjct: 1565 EKTAQLERSLQEEHV-AVAQLREEAERRAQQQAEAERAREEAERELER-WQLKANEALRL 1622
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/284 (19%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 44 LQQVTIIPHDEWKRIQDSLDRLTREAA--------CLRAERKAKKEMHLRSQEV---VKH 92
LQQ + ++ +R+Q+ +++ ++ A L AER+ + EM ++ + V
Sbjct: 2310 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2369
Query: 93 WTNTYAGMKEQKLEAKKKRDE--------------------EIEAERQILD-----LEEE 127
+ A +E +K+ +E +E +RQ D L E
Sbjct: 2370 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2429
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
I + + K+ ++ + ++E ++ LL + + + + S ++ ++ + E
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIE 2488
Query: 188 QLKLNIEKAFKEEQEKAEK-------------RHRERVALAKDHLKQIKEHEEEEERRKK 234
Q K +E+ F++E KA++ + R+R+ + + ++ + EE RRK+
Sbjct: 2489 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
E + E+ +RQ E ++L ++ + + E R L H ++
Sbjct: 2549 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
Score = 31.2 bits (69), Expect = 2.6
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 52 HDEWKRIQDSLDRLTREAACLRAERKA----KKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD +R+++++ L RE L+ E K +EM QE + T + ++
Sbjct: 2421 HDA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2479
Query: 108 KKKRDEEIEAERQILD--LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
+R+ IE E+ L+ ++E+ K + ++ E +Q Q + ER + S R
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQ 2537
Query: 166 KERDAQIEFRKSKIKSDKKW---------EEQLKLNIEKAFKEEQEKAEKRHRERVALAK 216
E + + ++ +++ ++ EE +L + EEQ +A H E V ++
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 81.3 bits (199), Expect = 2e-15
Identities = 91/432 (21%), Positives = 195/432 (45%), Gaps = 29/432 (6%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAI 138
K E+ L + + +T ++ +LEA ++R E ER+ + EE + K ++
Sbjct: 1927 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1986
Query: 139 ENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFK 198
++ + ER+K R E+++ + + ++ + K+ + + K + +
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046
Query: 199 EEQEKAEKRHRERVAL--AKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
+EQE + +E+ L + + + EE E + E++A + +RQ +E +
Sbjct: 2047 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-----VEEAE 2101
Query: 257 KLEKKREEMHESR---RRFLEHMQDKHIIKAVEQQQQEE-----------EDEKMRKFIK 302
+L++ EE ++R + E ++ + +A + Q E+ E EK +KF
Sbjct: 2102 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2159
Query: 303 AKKRLIQMGK-EKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEK 361
A++ L Q + E+E T RL + + N L E L ++L E AR ++ E E
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-QRLKAEATEAARQRSQVEEELFS 2218
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ +E +K + + AE RA+++++K+ +R + EA++ +A ++ ++ +
Sbjct: 2219 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278
Query: 422 CKADKEHQEVQD-AHIQQMAKNKFNAKQAK---QAELDYCRLTEALVAEKEKEFQDYARE 477
+ E Q A ++M K K A Q +AE + + + L E+ + Q+ +
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Query: 478 VIELESETTNKY 489
+ + +E T +
Sbjct: 2339 MAQQLAEETQGF 2350
Score = 80.9 bits (198), Expect = 3e-15
Identities = 90/438 (20%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
+AER+AK E+ R QE V ++QK + EE++ RQ E EI +
Sbjct: 1371 QAEREAK-ELQQRMQEEVVRREEAAVDAQQQK----RSIQEELQQLRQ--SSEAEIQAKA 1423
Query: 133 KRKKAIENAK----------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSK---- 178
++ +A E ++ + Q TER + G L + + +A+ + R+++
Sbjct: 1424 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1483
Query: 179 -----IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
++ + + + Q ++ + K E E A ++ R AL + L+ EE E R +
Sbjct: 1484 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA----EEAERRLR 1539
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
+ E + A +++ + +L+ KR E + +Q++H+ AV Q ++E
Sbjct: 1540 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE-- 1595
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
A++R Q + + A E+ ER +E L+ +L E++ + +A
Sbjct: 1596 ---------AERRAQQQAEAERAREEA--ERELERWQLKANEALRLRLQAEEVAQQKSLA 1644
Query: 354 EAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEER-------QRKIEAKEQLLAV 406
+AEAE +K E E++ + + + + A + + + + E++R Q+++ A+++L+ +
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1704
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK-QAELDYCRLTEALVA 465
+ + E++++ ++ + ++A + + A+ AK +AE++ ++A
Sbjct: 1705 RAETE---QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761
Query: 466 EKEKEFQDYAREVIELES 483
E+ + + +++ +E E+
Sbjct: 1762 EESRSTSEKSKQRLEAEA 1779
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/586 (22%), Positives = 241/586 (41%), Gaps = 111/586 (18%)
Query: 4 SSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKV-------DLQQVTIIPHD--- 53
SSE ++ R A E + +R EE +V+ L L ++ +LQ + +
Sbjct: 1414 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1473
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQ-----EVVKHWTNTYAGMKEQKLEA- 107
+ ++ Q+ +RL R+ ++RK + E+ L S+ E + ++E +L+A
Sbjct: 1474 QKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1532
Query: 108 ---KKKRDEEIEAERQILDLEE------EIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
++ R E+E RQ+ E E Q KR E Q + ++ H
Sbjct: 1533 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVA 1588
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWE-EQLKLNIEKAFKEEQEKAEKRHRERVALAKD 217
+ R ER AQ + + + + + E E+ +L +A + + E ++ +A A+
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648
Query: 218 HLKQIKEHEEEEERRKKYEEKDA-------EEIKRQNALYEIEMRKKLEKKRE------- 263
KQ +E E E RR K EE+ +E+++Q L E +++L ++E
Sbjct: 1649 E-KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1707
Query: 264 -EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-EAETHRL 321
E E +R+ LE + +A Q+ +E E ++A+ ++ K + E E+
Sbjct: 1708 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1767
Query: 322 MEKRRERIH----------------NFLSELLKEKLDNEDMIIARDIAEAE--------- 356
EK ++R+ L+E K + + AR AEAE
Sbjct: 1768 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1827
Query: 357 --------AEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMK 408
E E +EK+ +N+ L+ +AE A + EE+ Q K + +E+L + K
Sbjct: 1828 IGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886
Query: 409 ADQIFWEHEKE-----------------------KKCKADKEHQEVQDAHIQQMAKNKFN 445
A E +K +K A K E++ I+ A++
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946
Query: 446 AKQAKQAELDYCRLTEALVAEKE---KEFQDYAREVIELESETTNK 488
+K+ QAEL+ R + L AE+E +E ++ ++ + E E +
Sbjct: 1947 SKE--QAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQ 1989
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/515 (20%), Positives = 212/515 (41%), Gaps = 58/515 (11%)
Query: 13 RRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACL 72
R+ A+E+ + R E++ + + +LQQ ++ Q LD+L EA
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL-------QQEQSVLDQLRGEAEAA 2072
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R + +E ++++ + K A+++ +A+ L +E ++
Sbjct: 2073 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 133 KRKKAIENA----KQYQFYQTERVKNFHSGLLLSRVMKERDA---QIEFRKSKIKSDKKW 185
R+ E A KQ + E+ K F L + E++ +++ ++ + +
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD------ 239
EE +L E Q + V + + L ++K E E R +KD
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252
Query: 240 AEEIKRQNALYEIEMR--------KKLEKKREEMHESRRRFLEHMQDKHIIKAVE----- 286
EE ++ + E R +L + EE +R E M K ++AV+
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-KEKMQAVQEATRL 2311
Query: 287 -------QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKE 339
QQQ+E E+ R+ + K+++ Q E+ R +E R+R +E +
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371
Query: 340 KLDNEDMIIARDIAEAEAEWEKREREK--DEKNKAELKTIAEYRAIVMKNKEEEERQRKI 397
KL +M A+ AE +A+ +++ E+ ++ ++ EL T + + +++ E + +Q
Sbjct: 2372 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDH 2429
Query: 398 EAKEQLLAVMKADQIFWEHEKEKKCKADK----EHQEVQDAHIQQMAKNKFNAKQAKQAE 453
+A+ A+ + E EKEK + K + +E+Q +Q+ + +Q+ +E
Sbjct: 2430 DAERLREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484
Query: 454 LDYC----RLTEALVAEKEKEFQDYAREVIELESE 484
D R E A+ E+ FQD + +L E
Sbjct: 2485 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2519
Score = 65.5 bits (158), Expect = 1e-10
Identities = 115/509 (22%), Positives = 206/509 (40%), Gaps = 54/509 (10%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVT---IIPHDEWKRIQDSLDRLTREAACLR 73
RA+E E R E Q+ L ++ ++V + E ++ ++ +R R +
Sbjct: 1608 RAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG--K 1664
Query: 74 AERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKK----RDEEIEAERQILDLEEEIY 129
AE +A ++ L QE+ K G +Q+L A+++ R E + E+Q LEEE+
Sbjct: 1665 AEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
+ + A +Q + +V+ LL S+ E +++ KSK + + +
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE---------EERRKKYE---- 236
+L E A + AE+ R+R +D +Q E E E R K E
Sbjct: 1784 ELAEEAA--RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841
Query: 237 --EKDAE-EIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
EK+AE E R+ A E R++LE++ + L ++ + Q+ E+
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
+ R+ ++ + ++ EK A +E RI + + L+ K E +
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961
Query: 354 EAEAEWEKREREK------------DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
AE E +RE E+ + KA L+ + +A V + + ER + A++
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2021
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
LA A + EK ++ QE+Q Q +Q+ LD R E
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ------------QTLQQEQSVLDQLR-GE 2068
Query: 462 ALVAEKEKEFQDYAREVIELESETTNKYI 490
A A + E + AR E E+ + + +
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQV 2097
Score = 60.5 bits (145), Expect = 4e-09
Identities = 59/346 (17%), Positives = 161/346 (46%), Gaps = 17/346 (4%)
Query: 60 DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER 119
+ + ++ EAA L + + ++E + M ++K++A ++ ++AE
Sbjct: 2257 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEA 2315
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK-ERDAQIEFRKSK 178
++L ++E+ ++ R+ E+ +Q E + F L R + E A+ E K +
Sbjct: 2316 ELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2374
Query: 179 IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHR------ERVALAK--DHLKQIKEHEEEEE 230
+ + + + + + ++ K+ +E EK HR E+V L + + +Q +H+ E
Sbjct: 2375 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2434
Query: 231 RRKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R E E++ E+++++ L +++ + ++E++ + + + + ++
Sbjct: 2435 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2494
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIA 349
E+E K+ + + + Q +E++ + ME+ R+R+ + E + + + E+ +
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2554
Query: 350 RDIAEAEAEWEKRER-----EKDEKNKAELKTIAEYRAIVMKNKEE 390
+ + E ++R++ E++++ + +L+ + E + + EE
Sbjct: 2555 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2600
Score = 59.3 bits (142), Expect = 9e-09
Identities = 106/480 (22%), Positives = 202/480 (42%), Gaps = 50/480 (10%)
Query: 22 TEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKE 81
T++R E +Q L ++ + + P W +QD+ R + A A+ +A +E
Sbjct: 1181 TDVRQRELEQ------LGRQLRYYRESADPLGAW--LQDARRRQEQIQAMPLADSQAVRE 1232
Query: 82 MHLRSQ----EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
+ Q E+ +H + K +D E++ LE K K
Sbjct: 1233 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1292
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMK---ERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
+ Q Y R L S+ +K E ++E + ++ ++ EE+ +L
Sbjct: 1293 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQQRAEERERLAEV 1351
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR--QNALYEI 252
+A E+Q + + H + A A+ K++++ +EE R++ DA++ KR Q L ++
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411
Query: 253 EMRKKLE-----KKREEMHESRRRFLEHMQDKHI-IKAVEQQQQEEEDEKMRKFIKAKKR 306
+ E ++ E SR R E ++ + ++A E+Q+ E E +
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE--------LQA 1463
Query: 307 LIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK 366
L +E EA+ + E+ ER+ + + + K E + +R AEAEA RE+++
Sbjct: 1464 LRARAEEAEAQKRQAQEE-AERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQR 1519
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC---- 422
+ EL+ AE E RQ ++E Q+ ++ Q E E + K
Sbjct: 1520 ALQALEELRLQAE-------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1572
Query: 423 -KADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
K + + +Q+ H+ +A+ + A++ Q + + R E E E+ +Q A E + L
Sbjct: 1573 EKTAQLERSLQEEHV-AVAQLREEAERRAQQQAEAERAREEAERELER-WQLKANEALRL 1630
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/284 (19%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 44 LQQVTIIPHDEWKRIQDSLDRLTREAA--------CLRAERKAKKEMHLRSQEV---VKH 92
LQQ + ++ +R+Q+ +++ ++ A L AER+ + EM ++ + V
Sbjct: 2318 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2377
Query: 93 WTNTYAGMKEQKLEAKKKRDE--------------------EIEAERQILD-----LEEE 127
+ A +E +K+ +E +E +RQ D L E
Sbjct: 2378 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2437
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
I + + K+ ++ + ++E ++ LL + + + + S ++ ++ + E
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIE 2496
Query: 188 QLKLNIEKAFKEEQEKAEK-------------RHRERVALAKDHLKQIKEHEEEEERRKK 234
Q K +E+ F++E KA++ + R+R+ + + ++ + EE RRK+
Sbjct: 2497 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
E + E+ +RQ E ++L ++ + + E R L H ++
Sbjct: 2557 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2600
Score = 31.2 bits (69), Expect = 2.6
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 52 HDEWKRIQDSLDRLTREAACLRAERKA----KKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD +R+++++ L RE L+ E K +EM QE + T + ++
Sbjct: 2429 HDA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2487
Query: 108 KKKRDEEIEAERQILD--LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
+R+ IE E+ L+ ++E+ K + ++ E +Q Q + ER + S R
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQ 2545
Query: 166 KERDAQIEFRKSKIKSDKKW---------EEQLKLNIEKAFKEEQEKAEKRHRERVALAK 216
E + + ++ +++ ++ EE +L + EEQ +A H E V ++
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 81.3 bits (199), Expect = 2e-15
Identities = 91/432 (21%), Positives = 195/432 (45%), Gaps = 29/432 (6%)
Query: 79 KKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAI 138
K E+ L + + +T ++ +LEA ++R E ER+ + EE + K ++
Sbjct: 1968 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2027
Query: 139 ENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFK 198
++ + ER+K R E+++ + + ++ + K+ + + K + +
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087
Query: 199 EEQEKAEKRHRERVAL--AKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRK 256
+EQE + +E+ L + + + EE E + E++A + +RQ +E +
Sbjct: 2088 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ-----VEEAE 2142
Query: 257 KLEKKREEMHESR---RRFLEHMQDKHIIKAVEQQQQEE-----------EDEKMRKFIK 302
+L++ EE ++R + E ++ + +A + Q E+ E EK +KF
Sbjct: 2143 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKF-- 2200
Query: 303 AKKRLIQMGK-EKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEK 361
A++ L Q + E+E T RL + + N L E L ++L E AR ++ E E
Sbjct: 2201 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-QRLKAEATEAARQRSQVEEELFS 2259
Query: 362 REREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ +E +K + + AE RA+++++K+ +R + EA++ +A ++ ++ +
Sbjct: 2260 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319
Query: 422 CKADKEHQEVQD-AHIQQMAKNKFNAKQAK---QAELDYCRLTEALVAEKEKEFQDYARE 477
+ E Q A ++M K K A Q +AE + + + L E+ + Q+ +
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Query: 478 VIELESETTNKY 489
+ + +E T +
Sbjct: 2380 MAQQLAEETQGF 2391
Score = 80.9 bits (198), Expect = 3e-15
Identities = 90/438 (20%), Positives = 203/438 (46%), Gaps = 56/438 (12%)
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
+AER+AK E+ R QE V ++QK + EE++ RQ E EI +
Sbjct: 1412 QAEREAK-ELQQRMQEEVVRREEAAVDAQQQK----RSIQEELQQLRQ--SSEAEIQAKA 1464
Query: 133 KRKKAIENAK----------QYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSK---- 178
++ +A E ++ + Q TER + G L + + +A+ + R+++
Sbjct: 1465 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAE 1524
Query: 179 -----IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRK 233
++ + + + Q ++ + K E E A ++ R AL + L+ EE E R +
Sbjct: 1525 RLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA----EEAERRLR 1580
Query: 234 KYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
+ E + A +++ + +L+ KR E + +Q++H+ AV Q ++E
Sbjct: 1581 QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV--AVAQLREE-- 1636
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
A++R Q + + A E+ ER +E L+ +L E++ + +A
Sbjct: 1637 ---------AERRAQQQAEAERAREEA--ERELERWQLKANEALRLRLQAEEVAQQKSLA 1685
Query: 354 EAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEER-------QRKIEAKEQLLAV 406
+AEAE +K E E++ + + + + A + + + + E++R Q+++ A+++L+ +
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1745
Query: 407 MKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK-QAELDYCRLTEALVA 465
+ + E++++ ++ + ++A + + A+ AK +AE++ ++A
Sbjct: 1746 RAETE---QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802
Query: 466 EKEKEFQDYAREVIELES 483
E+ + + +++ +E E+
Sbjct: 1803 EESRSTSEKSKQRLEAEA 1820
Score = 78.6 bits (192), Expect = 1e-14
Identities = 131/586 (22%), Positives = 241/586 (41%), Gaps = 111/586 (18%)
Query: 4 SSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKV-------DLQQVTIIPHD--- 53
SSE ++ R A E + +R EE +V+ L L ++ +LQ + +
Sbjct: 1455 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1514
Query: 54 EWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQ-----EVVKHWTNTYAGMKEQKLEA- 107
+ ++ Q+ +RL R+ ++RK + E+ L S+ E + ++E +L+A
Sbjct: 1515 QKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1573
Query: 108 ---KKKRDEEIEAERQILDLEE------EIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
++ R E+E RQ+ E E Q KR E Q + ++ H
Sbjct: 1574 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE----RSLQEEHVA 1629
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWE-EQLKLNIEKAFKEEQEKAEKRHRERVALAKD 217
+ R ER AQ + + + + + E E+ +L +A + + E ++ +A A+
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689
Query: 218 HLKQIKEHEEEEERRKKYEEKDA-------EEIKRQNALYEIEMRKKLEKKRE------- 263
KQ +E E E RR K EE+ +E+++Q L E +++L ++E
Sbjct: 1690 E-KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE 1748
Query: 264 -EMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEK-EAETHRL 321
E E +R+ LE + +A Q+ +E E ++A+ ++ K + E E+
Sbjct: 1749 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1808
Query: 322 MEKRRERIH----------------NFLSELLKEKLDNEDMIIARDIAEAE--------- 356
EK ++R+ L+E K + + AR AEAE
Sbjct: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868
Query: 357 --------AEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMK 408
E E +EK+ +N+ L+ +AE A + EE+ Q K + +E+L + K
Sbjct: 1869 IGEATRLKTEAEIALKEKEAENE-RLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
Query: 409 ADQIFWEHEKE-----------------------KKCKADKEHQEVQDAHIQQMAKNKFN 445
A E +K +K A K E++ I+ A++
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987
Query: 446 AKQAKQAELDYCRLTEALVAEKE---KEFQDYAREVIELESETTNK 488
+K+ QAEL+ R + L AE+E +E ++ ++ + E E +
Sbjct: 1988 SKE--QAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQ 2030
Score = 68.6 bits (166), Expect = 1e-11
Identities = 107/515 (20%), Positives = 212/515 (41%), Gaps = 58/515 (11%)
Query: 13 RRCGRAKESTEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACL 72
R+ A+E+ + R E++ + + +LQQ ++ Q LD+L EA
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL-------QQEQSVLDQLRGEAEAA 2113
Query: 73 RAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQG 132
R + +E ++++ + K A+++ +A+ L +E ++
Sbjct: 2114 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 133 KRKKAIENA----KQYQFYQTERVKNFHSGLLLSRVMKERDA---QIEFRKSKIKSDKKW 185
R+ E A KQ + E+ K F L + E++ +++ ++ + +
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 186 EEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKD------ 239
EE +L E Q + V + + L ++K E E R +KD
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293
Query: 240 AEEIKRQNALYEIEMR--------KKLEKKREEMHESRRRFLEHMQDKHIIKAVE----- 286
EE ++ + E R +L + EE +R E M K ++AV+
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML-KEKMQAVQEATRL 2352
Query: 287 -------QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKE 339
QQQ+E E+ R+ + K+++ Q E+ R +E R+R +E +
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412
Query: 340 KLDNEDMIIARDIAEAEAEWEKREREK--DEKNKAELKTIAEYRAIVMKNKEEEERQRKI 397
KL +M A+ AE +A+ +++ E+ ++ ++ EL T + + +++ E + +Q
Sbjct: 2413 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT--QEKVTLVQTLEIQRQQSDH 2470
Query: 398 EAKEQLLAVMKADQIFWEHEKEKKCKADK----EHQEVQDAHIQQMAKNKFNAKQAKQAE 453
+A+ A+ + E EKEK + K + +E+Q +Q+ + +Q+ +E
Sbjct: 2471 DAERLREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525
Query: 454 LDYC----RLTEALVAEKEKEFQDYAREVIELESE 484
D R E A+ E+ FQD + +L E
Sbjct: 2526 KDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2560
Score = 65.5 bits (158), Expect = 1e-10
Identities = 115/509 (22%), Positives = 206/509 (40%), Gaps = 54/509 (10%)
Query: 17 RAKESTEIRNSEEDQVLYLPLLPSKVDLQQVT---IIPHDEWKRIQDSLDRLTREAACLR 73
RA+E E R E Q+ L ++ ++V + E ++ ++ +R R +
Sbjct: 1649 RAREEAE-RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG--K 1705
Query: 74 AERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKK----RDEEIEAERQILDLEEEIY 129
AE +A ++ L QE+ K G +Q+L A+++ R E + E+Q LEEE+
Sbjct: 1706 AEEQAVRQRELAEQELEKQ-RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764
Query: 130 KQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQL 189
+ + A +Q + +V+ LL S+ E +++ KSK + + +
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEE---------EERRKKYE---- 236
+L E A + AE+ R+R +D +Q E E E R K E
Sbjct: 1825 ELAEEAA--RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882
Query: 237 --EKDAE-EIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEE 293
EK+AE E R+ A E R++LE++ + L ++ + Q+ E+
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942
Query: 294 DEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIA 353
+ R+ ++ + ++ EK A +E RI + + L+ K E +
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002
Query: 354 EAEAEWEKREREK------------DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKE 401
AE E +RE E+ + KA L+ + +A V + + ER + A++
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2062
Query: 402 QLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTE 461
LA A + EK ++ QE+Q Q +Q+ LD R E
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ------------QTLQQEQSVLDQLR-GE 2109
Query: 462 ALVAEKEKEFQDYAREVIELESETTNKYI 490
A A + E + AR E E+ + + +
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQV 2138
Score = 60.5 bits (145), Expect = 4e-09
Identities = 59/346 (17%), Positives = 161/346 (46%), Gaps = 17/346 (4%)
Query: 60 DSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAER 119
+ + ++ EAA L + + ++E + M ++K++A ++ ++AE
Sbjct: 2298 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR-LKAEA 2356
Query: 120 QILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK-ERDAQIEFRKSK 178
++L ++E+ ++ R+ E+ +Q E + F L R + E A+ E K +
Sbjct: 2357 ELLQQQKELAQEQARRLQ-EDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2415
Query: 179 IKSDKKWEEQLKLNIEKAFKEEQEKAEKRHR------ERVALAK--DHLKQIKEHEEEEE 230
+ + + + + + ++ K+ +E EK HR E+V L + + +Q +H+ E
Sbjct: 2416 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2475
Query: 231 RRKKYE-EKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQ 289
R E E++ E+++++ L +++ + ++E++ + + + + ++
Sbjct: 2476 REAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2535
Query: 290 QEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIA 349
E+E K+ + + + Q +E++ + ME+ R+R+ + E + + + E+ +
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2595
Query: 350 RDIAEAEAEWEKRER-----EKDEKNKAELKTIAEYRAIVMKNKEE 390
+ + E ++R++ E++++ + +L+ + E + + EE
Sbjct: 2596 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2641
Score = 59.3 bits (142), Expect = 9e-09
Identities = 106/480 (22%), Positives = 202/480 (42%), Gaps = 50/480 (10%)
Query: 22 TEIRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKE 81
T++R E +Q L ++ + + P W +QD+ R + A A+ +A +E
Sbjct: 1222 TDVRQRELEQ------LGRQLRYYRESADPLGAW--LQDARRRQEQIQAMPLADSQAVRE 1273
Query: 82 MHLRSQ----EVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKA 137
+ Q E+ +H + K +D E++ LE K K
Sbjct: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333
Query: 138 IENAKQYQFYQTERVKNFHSGLLLSRVMK---ERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
+ Q Y R L S+ +K E ++E + ++ ++ EE+ +L
Sbjct: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQQRAEERERLAEV 1392
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKR--QNALYEI 252
+A E+Q + + H + A A+ K++++ +EE R++ DA++ KR Q L ++
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
Query: 253 EMRKKLE-----KKREEMHESRRRFLEHMQDKHI-IKAVEQQQQEEEDEKMRKFIKAKKR 306
+ E ++ E SR R E ++ + ++A E+Q+ E E +
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE--------LQA 1504
Query: 307 LIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK 366
L +E EA+ + E+ ER+ + + + K E + +R AEAEA RE+++
Sbjct: 1505 LRARAEEAEAQKRQAQEE-AERLRRQVQDESQRKRQAEVELASRVKAEAEA---AREKQR 1560
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKC---- 422
+ EL+ AE E RQ ++E Q+ ++ Q E E + K
Sbjct: 1561 ALQALEELRLQAE-------EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1613
Query: 423 -KADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIEL 481
K + + +Q+ H+ +A+ + A++ Q + + R E E E+ +Q A E + L
Sbjct: 1614 EKTAQLERSLQEEHV-AVAQLREEAERRAQQQAEAERAREEAERELER-WQLKANEALRL 1671
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/284 (19%), Positives = 122/284 (42%), Gaps = 50/284 (17%)
Query: 44 LQQVTIIPHDEWKRIQDSLDRLTREAA--------CLRAERKAKKEMHLRSQEV---VKH 92
LQQ + ++ +R+Q+ +++ ++ A L AER+ + EM ++ + V
Sbjct: 2359 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2418
Query: 93 WTNTYAGMKEQKLEAKKKRDE--------------------EIEAERQILD-----LEEE 127
+ A +E +K+ +E +E +RQ D L E
Sbjct: 2419 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2478
Query: 128 IYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEE 187
I + + K+ ++ + ++E ++ LL + + + + S ++ ++ + E
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER-FIE 2537
Query: 188 QLKLNIEKAFKEEQEKAEK-------------RHRERVALAKDHLKQIKEHEEEEERRKK 234
Q K +E+ F++E KA++ + R+R+ + + ++ + EE RRK+
Sbjct: 2538 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597
Query: 235 YEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
E + E+ +RQ E ++L ++ + + E R L H ++
Sbjct: 2598 EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2641
Score = 31.2 bits (69), Expect = 2.6
Identities = 39/180 (21%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 52 HDEWKRIQDSLDRLTREAACLRAERKA----KKEMHLRSQEVVKHWTNTYAGMKEQKLEA 107
HD +R+++++ L RE L+ E K +EM QE + T + ++
Sbjct: 2470 HDA-ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2528
Query: 108 KKKRDEEIEAERQILD--LEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLLSRVM 165
+R+ IE E+ L+ ++E+ K + ++ E +Q Q + ER + S R
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLRE--EQQRQQQQMEQERQRLVASMEEARRRQ 2586
Query: 166 KERDAQIEFRKSKIKSDKKW---------EEQLKLNIEKAFKEEQEKAEKRHRERVALAK 216
E + + ++ +++ ++ EE +L + EEQ +A H E V ++
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 80.5 bits (197), Expect = 4e-15
Identities = 91/391 (23%), Positives = 189/391 (48%), Gaps = 38/391 (9%)
Query: 77 KAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKK 136
K KE S E+ ++ T T +KE+ E ++K +E+E+ + L K KRK
Sbjct: 194 KLTKERDAPSLELYRN-TITDEELKEKNAELQEKL-RLVESEKSEIQLN---VKDLKRK- 247
Query: 137 AIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRK-----SKIKSDKKWEEQLKL 191
+E A+ Q +V+ G L V + AQ+E + ++ + +K W ++
Sbjct: 248 -LERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE--- 303
Query: 192 NIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEE--KDAEEIKRQNAL 249
EK ++E++ E+ + R K ++ K HE+EE+ R++ ++ + E+I+ Q
Sbjct: 304 --EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEK 361
Query: 250 YEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQ 309
E +K+ ++ E++ E + E ++ + ++Q+E+ EKM + K + +
Sbjct: 362 IR-EQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDE 420
Query: 310 MGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEK 369
+E+E E R EK RE L E+++ D E+ + R++ E E E++ +E++EK
Sbjct: 421 KIREQEEEMWRQEEKIRE-----LEEMMQ---DQEEKL--REVEEKMQEEEEKMQEQEEK 470
Query: 370 NKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWE-----HEKEKKCKA 424
+ + + I E + ++ +++ KI +E+ + + ++ WE E+E+K +
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE--KMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 425 DKEHQEVQDAHIQQMAKNKFNAKQAKQAELD 455
+E Q+ + Q + K ++ + EL+
Sbjct: 529 QEEKMREQEVRLWQQ-EEKMQEQEVRLQELE 558
Score = 63.9 bits (154), Expect = 4e-10
Identities = 86/395 (21%), Positives = 174/395 (44%), Gaps = 31/395 (7%)
Query: 109 KKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNF----HSGLLLSRV 164
KKR E++ + I K R + K+ + E +F G + ++
Sbjct: 136 KKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKL 195
Query: 165 MKERDA-QIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAE--------KRHRERVALA 215
KERDA +E ++ I ++ E+ +L EK E EK+E KR ER L
Sbjct: 196 TKERDAPSLELYRNTITDEELKEKNAELQ-EKLRLVESEKSEIQLNVKDLKRKLERAQLL 254
Query: 216 KDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEH 275
+ + + + E + +E + K Q + E E+ L +++EE + ++
Sbjct: 255 ------LPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQE 308
Query: 276 MQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSE 335
++K + ++ ++QEE+ + + + ++ I+ ++K + ++ E+I +
Sbjct: 309 QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK 368
Query: 336 LLK--EKLDNEDMIIARDIAEAEAE-WEKRE--REKDEKNKAEL-KTIAEYRAIVMKNKE 389
+ + EK+ +D I E E E W + E RE++EK + ++ + + R K +E
Sbjct: 369 MWRQEEKIREQD----EKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIRE 424
Query: 390 EEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQA 449
+EE + E K + L M DQ E E+K + ++E + Q+ IQ+ + K ++
Sbjct: 425 QEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQ-EEKIQEQEE 483
Query: 450 KQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
K + E + E+E++ ++ E E +
Sbjct: 484 KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEK 518
Score = 58.9 bits (141), Expect = 1e-08
Identities = 73/343 (21%), Positives = 160/343 (46%), Gaps = 37/343 (10%)
Query: 19 KESTEIRNSEEDQV-LYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERK 77
+E + SE+ ++ L + L K++ Q+ ++P + +Q DRL +E + A+ +
Sbjct: 224 QEKLRLVESEKSEIQLNVKDLKRKLERAQL-LLPQQQ---LQVEADRLGKELQSVSAKLQ 279
Query: 78 AKKEMH-----LRSQEVVKHWTNTYA------GMKEQKL-----EAKKKRDEEI--EAER 119
A+ E + L Q+ K W M EQ+L E K R EE E E
Sbjct: 280 AQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE 339
Query: 120 QILDLEEEIYKQGKR----KKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFR 175
+I + E+++++Q ++ ++ I ++ + Q E+++ + R +
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 176 KSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEH-EEEEERRKK 234
+ + + +K W ++ K+ + EQE+ R E++ ++ ++ +E E EE+ ++
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459
Query: 235 YEEK---DAEEIKRQNALYEIEMRK-----KLEKKREEMHESRRRFLEHMQDKHIIKAVE 286
EEK E+I+RQ + + K KL K+ E++ E + + ++K + +
Sbjct: 460 EEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK-MWRQEEKMWEQEEK 518
Query: 287 QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERI 329
Q+QEE+ ++ + ++ ++ + +EK E +++ ER+
Sbjct: 519 MQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 48.1 bits (113), Expect = 2e-05
Identities = 81/417 (19%), Positives = 168/417 (40%), Gaps = 76/417 (18%)
Query: 112 DEEIEAERQILDLEEEIYKQGK-----RKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK 166
DE+ + + I LE++ + K R+K+I + K +Q +
Sbjct: 27 DEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADEKFFQ-------------------LS 67
Query: 167 ERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKE-------------EQEKAEKRHRERVA 213
E +A +E RK + K+W+E L + K+ + E E V
Sbjct: 68 EMEAYLENRKRR--GTKRWDEDDDLEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVK 125
Query: 214 LAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQ-NALYEIEMRKKLEKK--REEMHESRR 270
D +K + +E+ K Y + IK+ L E+ +K+ E E +H
Sbjct: 126 KNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHA 185
Query: 271 ----RFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETH---RLME 323
++E + + ++E + DE++ KEK AE RL+E
Sbjct: 186 VRMGTYIEKLTKERDAPSLELYRNTITDEEL--------------KEKNAELQEKLRLVE 231
Query: 324 KRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK-DEKNKAELKTIAEYRA 382
+ I + +L K KL+ +++ + + EA+ +E + K +A+++ +
Sbjct: 232 SEKSEIQLNVKDL-KRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNL 290
Query: 383 IVMKNKE----EEERQRKIEAK--EQLLAVMKADQIFWE-----HEKEKKCKADKEHQEV 431
+ + +E +EE+ ++ E K EQ L + + ++ W HE+E+K + ++
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWR 350
Query: 432 QDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESETTNK 488
Q+ I++ + ++ + + R + + E+E+E ++ E E + K
Sbjct: 351 QEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEK 407
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 80.5 bits (197), Expect = 4e-15
Identities = 91/391 (23%), Positives = 189/391 (48%), Gaps = 38/391 (9%)
Query: 77 KAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKK 136
K KE S E+ ++ T T +KE+ E ++K +E+E+ + L K KRK
Sbjct: 194 KLTKERDALSLELYRN-TITDEELKEKNAELQEKL-RLVESEKSEIQLN---VKDLKRK- 247
Query: 137 AIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRK-----SKIKSDKKWEEQLKL 191
+E A+ Q +V+ G L V + AQ+E + ++ + +K W ++
Sbjct: 248 -LERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE--- 303
Query: 192 NIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEE--KDAEEIKRQNAL 249
EK ++E++ E+ + R K ++ K HE+EE+ R++ ++ + E+I+ Q
Sbjct: 304 --EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEK 361
Query: 250 YEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQ 309
E +K+ ++ E++ E + E ++ + ++Q+E+ EKM + K + +
Sbjct: 362 IR-EQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDE 420
Query: 310 MGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEK 369
+E+E E R EK RE L E+++ D E+ + R++ E E E++ +E++EK
Sbjct: 421 KIREQEEEMWRQEEKIRE-----LEEMMQ---DQEEKL--REVEEKMQEEEEKMQEQEEK 470
Query: 370 NKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWE-----HEKEKKCKA 424
+ + + I E + ++ +++ KI +E+ + + ++ WE E+E+K +
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEE--KMWRQEEKMWEQEEKMQEQEEKMQR 528
Query: 425 DKEHQEVQDAHIQQMAKNKFNAKQAKQAELD 455
+E Q+ + Q + K ++ + EL+
Sbjct: 529 QEEKMREQEVRLWQQ-EEKMQEQEVRLQELE 558
Score = 63.9 bits (154), Expect = 4e-10
Identities = 86/395 (21%), Positives = 174/395 (44%), Gaps = 31/395 (7%)
Query: 109 KKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNF----HSGLLLSRV 164
KKR E++ + I K R + K+ + E +F G + ++
Sbjct: 136 KKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEKL 195
Query: 165 MKERDA-QIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAE--------KRHRERVALA 215
KERDA +E ++ I ++ E+ +L EK E EK+E KR ER L
Sbjct: 196 TKERDALSLELYRNTITDEELKEKNAELQ-EKLRLVESEKSEIQLNVKDLKRKLERAQLL 254
Query: 216 KDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEH 275
+ + + + E + +E + K Q + E E+ L +++EE + ++
Sbjct: 255 ------LPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQE 308
Query: 276 MQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSE 335
++K + ++ ++QEE+ + + + ++ I+ ++K + ++ E+I +
Sbjct: 309 QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK 368
Query: 336 LLK--EKLDNEDMIIARDIAEAEAE-WEKRE--REKDEKNKAEL-KTIAEYRAIVMKNKE 389
+ + EK+ +D I E E E W + E RE++EK + ++ + + R K +E
Sbjct: 369 MWRQEEKIREQD----EKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIRE 424
Query: 390 EEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQA 449
+EE + E K + L M DQ E E+K + ++E + Q+ IQ+ + K ++
Sbjct: 425 QEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQ-EEKIQEQEE 483
Query: 450 KQAELDYCRLTEALVAEKEKEFQDYAREVIELESE 484
K + E + E+E++ ++ E E +
Sbjct: 484 KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEK 518
Score = 58.9 bits (141), Expect = 1e-08
Identities = 73/343 (21%), Positives = 160/343 (46%), Gaps = 37/343 (10%)
Query: 19 KESTEIRNSEEDQV-LYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERK 77
+E + SE+ ++ L + L K++ Q+ ++P + +Q DRL +E + A+ +
Sbjct: 224 QEKLRLVESEKSEIQLNVKDLKRKLERAQL-LLPQQQ---LQVEADRLGKELQSVSAKLQ 279
Query: 78 AKKEMH-----LRSQEVVKHWTNTYA------GMKEQKL-----EAKKKRDEEI--EAER 119
A+ E + L Q+ K W M EQ+L E K R EE E E
Sbjct: 280 AQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEE 339
Query: 120 QILDLEEEIYKQGKR----KKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFR 175
+I + E+++++Q ++ ++ I ++ + Q E+++ + R +
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 176 KSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEH-EEEEERRKK 234
+ + + +K W ++ K+ + EQE+ R E++ ++ ++ +E E EE+ ++
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQE 459
Query: 235 YEEK---DAEEIKRQNALYEIEMRK-----KLEKKREEMHESRRRFLEHMQDKHIIKAVE 286
EEK E+I+RQ + + K KL K+ E++ E + + ++K + +
Sbjct: 460 EEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK-MWRQEEKMWEQEEK 518
Query: 287 QQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERI 329
Q+QEE+ ++ + ++ ++ + +EK E +++ ER+
Sbjct: 519 MQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 48.1 bits (113), Expect = 2e-05
Identities = 83/421 (19%), Positives = 172/421 (40%), Gaps = 84/421 (19%)
Query: 112 DEEIEAERQILDLEEEIYKQGK-----RKKAIENAKQYQFYQTERVKNFHSGLLLSRVMK 166
DE+ + + I LE++ + K R+K+I + K +Q +
Sbjct: 27 DEDSDLDFHINKLEQQSKVRNKGHGKPREKSIADEKFFQ-------------------LS 67
Query: 167 ERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHE 226
E +A +E RK + K+W+E L + E K K +RV + + E
Sbjct: 68 EMEAYLENRKRR--GTKRWDEDDDLE-----ESEDSKQCKESLKRVTFT------LPDDE 114
Query: 227 EEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVE 286
E+ + +K+++E+K +K+ EK E+ + R+R + + +
Sbjct: 115 AIEDAGVSHVKKNSDEVKSS-------FKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTA 167
Query: 287 QQQQEEE--------DEKMR------KFIKAKKRLI----------QMGKEKEAETH--- 319
Q++ E D +R K K + L + KEK AE
Sbjct: 168 QKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAELQEKL 227
Query: 320 RLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREK-DEKNKAELKTIA 378
RL+E + I + +L K KL+ +++ + + EA+ +E + K +A+++
Sbjct: 228 RLVESEKSEIQLNVKDL-KRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENE 286
Query: 379 EYRAIVMKNKE----EEERQRKIEAK--EQLLAVMKADQIFWE-----HEKEKKCKADKE 427
+ + + +E +EE+ ++ E K EQ L + + ++ W HE+E+K + ++
Sbjct: 287 LWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQED 346
Query: 428 HQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYAREVIELESETTN 487
Q+ I++ + ++ + + R + + E+E+E ++ E E +
Sbjct: 347 KMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQE 406
Query: 488 K 488
K
Sbjct: 407 K 407
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 78.6 bits (192), Expect = 1e-14
Identities = 63/260 (24%), Positives = 123/260 (47%), Gaps = 38/260 (14%)
Query: 192 NIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNALYE 251
+I K + ++E R RER + K+ +E E ++ERR++ + K E +R+ +
Sbjct: 24 HISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGK 83
Query: 252 IEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMG 311
E KK E+K+EE +RR + E ++ EE++++ +K K + R + G
Sbjct: 84 KE--KKGERKKEERERKKRR-----------REKENKEGEEKEKRKKKEKKERGRTSKEG 130
Query: 312 KEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNK 371
KE+E + R E+R+ER E + E ++ERE+ E+ K
Sbjct: 131 KERERKEERKREERKER-------------------------ERKKEEREKERERKERKK 165
Query: 372 AELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEV 431
E K + E + + +E ++R+ KE+ + ++ + E++KK + KE Q+
Sbjct: 166 RERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKD 225
Query: 432 QDAHIQQMAKNKFNAKQAKQ 451
+ + ++ + K K+ K+
Sbjct: 226 RQTNWREKERGKRERKERKK 245
Score = 74.3 bits (181), Expect = 3e-13
Identities = 67/237 (28%), Positives = 110/237 (46%), Gaps = 30/237 (12%)
Query: 165 MKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKE 224
++ER+ +IE RK + K+ E + K + K ++E+ ++R RER K ++ KE
Sbjct: 38 IREREREIETRK---EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERK-KE 93
Query: 225 HEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKA 284
E ++RR++ E K+ EE E RKK EKK + E +++ +
Sbjct: 94 ERERKKRRREKENKEGEEK---------EKRKKKEKKERGRTSKEGKERERKEERKREER 144
Query: 285 VEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNE 344
E+++++EE EK R+ + KKR + EKE E K R++ E KE+
Sbjct: 145 KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER---- 200
Query: 345 DMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEY-RAIVMKNKEEEERQRKIEAK 400
E+RER+K+ K K E K + R + KE +R+RK K
Sbjct: 201 ------------ERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 65.9 bits (159), Expect = 9e-11
Identities = 72/271 (26%), Positives = 127/271 (46%), Gaps = 69/271 (25%)
Query: 101 KEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLL 160
+E+++E +K+ +E E+ER+ +E ++ KRK+ E ++ ER K G
Sbjct: 41 REREIETRKEGKKERESERK-----KERREREKRKREREKERK-----RERGKKEKKG-- 88
Query: 161 LSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDHLK 220
R +ER+ + ++ + K +K+ EE KE+++K EK+ R R + K
Sbjct: 89 -ERKKEERERK---KRRREKENKEGEE----------KEKRKKKEKKERGRTS------K 128
Query: 221 QIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQDKH 280
+ KE E +EER++ E RK+ E+K+EE + R R K
Sbjct: 129 EGKERERKEERKR-------------------EERKERERKKEEREKERER-------KE 162
Query: 281 IIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLSELLKEK 340
K +Q E+E+E+ K K +K+ + KE++ E R ++RRER KE+
Sbjct: 163 RKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERER--KERRER--------KKER 212
Query: 341 LDNEDMIIARDIAEAEAEWEKREREKDEKNK 371
E+ R + + W ++ER K E+ +
Sbjct: 213 KKKEERKKERQ-KDRQTNWREKERGKRERKE 242
Score = 60.8 bits (146), Expect = 3e-09
Identities = 57/198 (28%), Positives = 93/198 (46%), Gaps = 21/198 (10%)
Query: 99 GMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSG 158
G KE++ E KK+R E + +R+ +E ++GK++K E K+ + ER K
Sbjct: 51 GKKERESERKKERREREKRKRE--REKERKRERGKKEKKGERKKE----ERERKKR---- 100
Query: 159 LLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDH 218
R KE E K K K K+ K E+ KEE+ K E+R ++
Sbjct: 101 ----RREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEER-KREERKE------RER 149
Query: 219 LKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
K+ +E E E + RKK E K E + + E + RKK E+ R+E + R R +
Sbjct: 150 KKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERK 209
Query: 279 KHIIKAVEQQQQEEEDEK 296
K K E++++ ++D +
Sbjct: 210 KERKKKEERKKERQKDRQ 227
Score = 57.0 bits (136), Expect = 4e-08
Identities = 50/191 (26%), Positives = 94/191 (49%), Gaps = 7/191 (3%)
Query: 76 RKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKRK 135
+K ++E R +E K G KE+K E KK+ E + R+ + E E ++ K+K
Sbjct: 60 KKERREREKRKREREKE-RKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKK 118
Query: 136 KAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFR-KSKIKSDKKWEEQLKLNIE 194
+ E + + + K KER+ + E R K + + ++K E+ ++ +
Sbjct: 119 EKKERGRTSKEGKERERKEERK----REERKERERKKEEREKERERKERKKRERKQVGEK 174
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEE-EEERRKKYEEKDAEEIKRQNALYEIE 253
+ ++E+E+ E++ RER + ++ KE E ++ER+KK E K + RQ E E
Sbjct: 175 EEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKE 234
Query: 254 MRKKLEKKREE 264
K+ K+R++
Sbjct: 235 RGKRERKERKK 245
Score = 52.4 bits (124), Expect = 1e-06
Identities = 55/222 (24%), Positives = 102/222 (45%), Gaps = 31/222 (13%)
Query: 251 EIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQM 310
EIE RK+ +K+RE + RR E+++++ E EK RK + KK +
Sbjct: 44 EIETRKEGKKERESERKKERR--------------EREKRKREREKERKRERGKKE--KK 87
Query: 311 GKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKN 370
G+ K+ E R +KRR N E +++ E R E + K ER+++E+
Sbjct: 88 GERKKEERER--KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK 145
Query: 371 KAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKAD---KE 427
+ E K + +E+E R+RK K + V + ++ E E++++ K + KE
Sbjct: 146 ERERKK---------EEREKE-RERKERKKRERKQVGEKEEERKEKERKERKKRERNRKE 195
Query: 428 HQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEK 469
++ ++ ++ K + K+ ++ E R T E+ K
Sbjct: 196 RKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGK 237
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/160 (23%), Positives = 79/160 (49%), Gaps = 19/160 (11%)
Query: 75 ERKAKKEMHLRSQEVVKHWTNTYAGMKEQKLEAKKKRDEEIEAERQILDLEEEIYKQGKR 134
E K +E R ++ K T KE++ + ++KR+E E ER+ + E+E ++ ++
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERK 164
Query: 135 KKAIENAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIE 194
K+ KQ + ER KE++ + ++ + + ++K E + K E
Sbjct: 165 KR---ERKQVGEKEEER--------------KEKERKERKKRERNRKERKKERERKERRE 207
Query: 195 KAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKK 234
+ K+E++K E+R +ER + + ++ + + E + RKK
Sbjct: 208 R--KKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 38.5 bits (88), Expect = 0.016
Identities = 40/166 (24%), Positives = 77/166 (46%), Gaps = 22/166 (13%)
Query: 312 KEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNK 371
+E+E ET + +K RE SE KE+ + E R E E + E+ ++EK + K
Sbjct: 41 REREIETRKEGKKERE------SERKKERREREKRKRER---EKERKRERGKKEKKGERK 91
Query: 372 AELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEV 431
E + + R + EE+ +RK + K++ K + E ++E+K + KE +
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGK-ERERKEERKREERKERERK 150
Query: 432 QDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYARE 477
++ ++ + + ++ KQ V EKE+E ++ R+
Sbjct: 151 KEEREKERERKERKKRERKQ------------VGEKEEERKEKERK 184
Score = 33.5 bits (75), Expect = 0.52
Identities = 29/133 (21%), Positives = 58/133 (43%), Gaps = 8/133 (6%)
Query: 359 WEKREREKD---EKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKADQIFWE 415
W+ RE++ E K K R + +E+ +R+R+ E K + K + E
Sbjct: 34 WQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKE 93
Query: 416 HEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKEFQDYA 475
+ KK + +KE++E ++ ++ + K + +K+ + E K +E ++
Sbjct: 94 ERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEG-----KERERKEERKREERKERE 148
Query: 476 REVIELESETTNK 488
R+ E E E K
Sbjct: 149 RKKEEREKERERK 161
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 78.6 bits (192), Expect = 1e-14
Identities = 74/351 (21%), Positives = 167/351 (47%), Gaps = 25/351 (7%)
Query: 106 EAKKKRDEEI----EAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLLL 161
EA K+++E++ E +R + ++ KR+ + + K Y + E+++ + L
Sbjct: 576 EALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMK-EQMEKVEADLTR 634
Query: 162 SRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKA---EKRHRERVALAKDH 218
S+ ++E+ ++ EF +++E+Q+ +E + EQEK ++ + E+ +L +DH
Sbjct: 635 SKSLREKQSK-EFLWQLEDIRQRYEQQI---VELKLEHEQEKTHLLQQHNAEKDSLVRDH 690
Query: 219 LKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHMQD 278
++I+ E++ E +E K+++A +M ++ K REE+ + + + +
Sbjct: 691 EREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVE 750
Query: 279 KHIIKAVEQQQQEEEDEKMRKFIKA--KKRLIQMGKEKEAETHRLMEKRRERIHNFLSEL 336
+++ E+Q+ E E + +KA +K I++ K AET +EK ++ E
Sbjct: 751 LGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKE- 809
Query: 337 LKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRK 396
+KL I IAE + + E ++ A AE R ++ K E+E+++
Sbjct: 810 YTQKLAKSSQI----IAELQTTISSLKEENSQQQLA-----AERRLQDVRQKFEDEKKQL 860
Query: 397 IEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAK 447
I +Q + V++ D++ + + + +H+E++ + ++ K
Sbjct: 861 IRDNDQAIKVLQ-DELENRSNQVRCAEKKLQHKELESQEQITYIRQEYETK 910
Score = 62.8 bits (151), Expect = 8e-10
Identities = 99/487 (20%), Positives = 202/487 (41%), Gaps = 77/487 (15%)
Query: 24 IRNSEEDQVLYLPLLPSKVDLQQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKEMH 83
IR ++EDQ+ L K +Q T +++W++ +L A + E+ ++ H
Sbjct: 329 IRETKEDQIAEL-----KKICEQSTESLNNDWEK------KLHNAVAEMEQEKFDLQKQH 377
Query: 84 LRSQEVVKHWTNTYAGMKEQKLEAKKKRD----EEIEAERQILDLEEEIYKQGKRKKAIE 139
+ + + TN E + A+ + +E+EA Q L E E ++K E
Sbjct: 378 TENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQE 437
Query: 140 NAKQYQFYQTERVKNFHSGLLLSRVMKERDAQIEFRKSKIKS-DKKWEEQLKLNIEKAFK 198
A+ + YQ + + + KE+D + + +K K++ + L K
Sbjct: 438 KAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINL-----LK 492
Query: 199 EEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAE-----EIKRQNALYEI- 252
+E + + + + ++ Q+K+ +E E ++K + +D E E +YE
Sbjct: 493 QEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKK 552
Query: 253 --EMRKKLEKKREEMHESRRRFLEHMQDKHI----IKAVEQQQQEEEDEKMRKFIKAKKR 306
+++ +L+K +E+ + +F E +++K + V++ Q ++ D + +F KR
Sbjct: 553 AHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEF----KR 608
Query: 307 LIQMGKEKE-AETHRLMEKRRERIHNFLSELLKEKLDNEDMIIARDI--------AEAEA 357
+++ EK AE MEK + S+ L+EK E + DI E +
Sbjct: 609 QVELNSEKVYAEMKEQMEKVEADLTR--SKSLREKQSKEFLWQLEDIRQRYEQQIVELKL 666
Query: 358 EWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEERQRKIEAKEQLLAVMKAD-QIFWEH 416
E E+ + +++ AE ++ ++N E++ R +E + Q+ K D Q+ +
Sbjct: 667 EHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADM 726
Query: 417 E----------------------------KEKKCKADKEHQEVQDAHIQQMAKNKFNAKQ 448
E +E+K +A +EH+ V + + K K K+
Sbjct: 727 EAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKK 786
Query: 449 AKQAELD 455
AE +
Sbjct: 787 THAAETE 793
Score = 51.6 bits (122), Expect = 2e-06
Identities = 63/304 (20%), Positives = 133/304 (43%), Gaps = 27/304 (8%)
Query: 190 KLNIEKAFKEEQEKAEKRHRERVALAKDHLKQIKEHEEEEERRKKYEEKDAEEIKRQNAL 249
K ++ K+ + R RE+ K + + K HEE+ + ++K++ + ++R+N
Sbjct: 234 KFSLRKSSSFHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNE 293
Query: 250 YEIEMRKKLEKKREEMHESRRRFLEHMQDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQ 309
E E++ K+ E E+ R+ + +Q +I+ + ++ +ED+ + +
Sbjct: 294 IE-ELKTLYRSKQHETEETIRKLEKKVQT--LIRDCQVIRETKEDQ-----------IAE 339
Query: 310 MGKEKEAETHRLMEKRRERIHNFLSELLKEKLDNEDM---IIARDIAEAEAEWEKREREK 366
+ K E T L +++HN ++E+ +EK D + I + + K E E
Sbjct: 340 LKKICEQSTESLNNDWEKKLHNAVAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEY 399
Query: 367 DEKNKAELKTIAEYRAIVMKNKEEEE-----RQRKIEAKEQLLAVMKADQIFWEHEKEKK 421
+ ++ I E A V + E E RQ+ I+ K +L + QI +E K
Sbjct: 400 MAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAEL---ERCYQITCSELQEVK 456
Query: 422 CKADKEHQEVQDAHIQQMAKNKFNAKQAKQAELDYCRLTEALVAEKEKE-FQDYAREVIE 480
+ + H+E +D + +N + A+++ + AL A K ++ + V +
Sbjct: 457 ARRNTLHKE-KDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQ 515
Query: 481 LESE 484
L+ +
Sbjct: 516 LKQQ 519
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,118,227
Number of Sequences: 37866
Number of extensions: 1014447
Number of successful extensions: 28250
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 524
Number of HSP's successfully gapped in prelim test: 1364
Number of HSP's that attempted gapping in prelim test: 7561
Number of HSP's gapped (non-prelim): 7921
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.