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Search of human proteins with 109715829
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
(260 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 519 e-148
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 92 5e-19
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 91 1e-18
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 89 4e-18
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 87 1e-17
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 82 5e-16
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 80 1e-15
gi|40254992 carbonic reductase 4 [Homo sapiens] 80 2e-15
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 78 9e-15
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 77 1e-14
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 74 1e-13
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 74 1e-13
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 72 5e-13
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 72 6e-13
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 70 1e-12
gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ... 70 1e-12
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 70 2e-12
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 67 2e-11
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B... 65 6e-11
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 64 2e-10
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 64 2e-10
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 64 2e-10
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 64 2e-10
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 63 2e-10
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo... 63 3e-10
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 63 3e-10
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 63 3e-10
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 62 7e-10
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ... 62 7e-10
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 61 9e-10
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 519 bits (1337), Expect = e-148
Identities = 260/260 (100%), Positives = 260/260 (100%)
Query: 1 MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGY 60
MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGY
Sbjct: 1 MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGY 60
Query: 61 PGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNV 120
PGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNV
Sbjct: 61 PGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNV 120
Query: 121 NVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGL 180
NVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGL
Sbjct: 121 NVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGL 180
Query: 181 RQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVL 240
RQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVL
Sbjct: 181 RQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVL 240
Query: 241 STPAHIQIGDIQMRPTEQVT 260
STPAHIQIGDIQMRPTEQVT
Sbjct: 241 STPAHIQIGDIQMRPTEQVT 260
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 92.0 bits (227), Expect = 5e-19
Identities = 63/194 (32%), Positives = 91/194 (46%), Gaps = 7/194 (3%)
Query: 13 LALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLS 72
+ L+TGA GIG ++ +V +EE AAEC+ G T Y D S
Sbjct: 38 IVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGV--TAHAYVVDCS 95
Query: 73 NEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREA 132
N E+I + ++ + V I +NNAG P LLS F VN+L T+
Sbjct: 96 NREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKAL 155
Query: 133 YQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE-AQTHI 191
SM ERN GHI+ + S+ GH +P + Y ++K+A GL EL+ +T I
Sbjct: 156 LPSMMERN--HGHIVTVASVCGHEGIPYLIP--YCSSKFAAVGFHRGLTSELQALGKTGI 211
Query: 192 RATCISPGVVETQF 205
+ +C+ P V T F
Sbjct: 212 KTSCLCPVFVNTGF 225
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 90.5 bits (223), Expect = 1e-18
Identities = 77/260 (29%), Positives = 133/260 (51%), Gaps = 22/260 (8%)
Query: 1 MARPGMERWRD----RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECK 56
MA GM R RD ++ALVT ++ GIG A+AR L Q G VV +R N+++ A +
Sbjct: 19 MASSGMTR-RDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQ 77
Query: 57 SAG--YPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARP--DTLLSGSTS 112
G GT+ C + ED + + H G+DI ++NA + P +++ +
Sbjct: 78 GEGLSVTGTV----CHVGKAEDRERLVATAVKLHGGIDILVSNAAV-NPFFGSIMDVTEE 132
Query: 113 GWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYA 172
W ++NV A ++ T+ M++R G ++ ++S++ P Y+ +K A
Sbjct: 133 VWDKTLDINVKAPALMTKAVVPEMEKRG--GGSVVIVSSIAAFS--PSPGFSPYNVSKTA 188
Query: 173 VTALTEGLRQELREAQTHIRATCISPGVVETQFAFKL-HDKDPEKAAATYEQMKCL-KPE 230
+ LT+ L EL A +IR C++PG+++T F+ L DK+ E++ +++ L +PE
Sbjct: 189 LLGLTKTLAIEL--APRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPE 246
Query: 231 DVAEAVIYVLSTPAHIQIGD 250
D A V ++ S A G+
Sbjct: 247 DCAGIVSFLCSEDASYITGE 266
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 89.0 bits (219), Expect = 4e-18
Identities = 68/231 (29%), Positives = 107/231 (46%), Gaps = 17/231 (7%)
Query: 13 LALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLS 72
+ L+TGA GIG A + K+V +EE AA+CK G + + D S
Sbjct: 38 IVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLG--AKVHTFVVDCS 95
Query: 73 NEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREA 132
N EDI S ++++ V I +NNAG+ L + + F VNVLA T+
Sbjct: 96 NREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAF 155
Query: 133 YQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQ-THI 191
+M + N GHI+ + S +GH +P + Y ++K+A + L EL Q T +
Sbjct: 156 LPAMTKNN--HGHIVTVASAAGHVSVPFLLA--YCSSKFAAVGFHKTLTDELAALQITGV 211
Query: 192 RATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLST 242
+ TC+ P V T F K+P + L+PE+V +++ + T
Sbjct: 212 KTTCLCPNFVNTGFI-----KNPSTSLG-----PTLEPEEVVNRLMHGILT 252
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 87.0 bits (214), Expect = 1e-17
Identities = 70/241 (29%), Positives = 115/241 (47%), Gaps = 20/241 (8%)
Query: 8 RWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPY 67
R+ ++ +VTG GIGA + RA V G +VV C + +E PG +
Sbjct: 6 RYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDK-----DESGGRALEQELPGAVF-I 59
Query: 68 RCDLSNEEDILSMFSAIRSQHSGVDICINNAG-LARPDTLLSGSTSGWKDMFNVNVLALS 126
CD++ E+D+ ++ S + +D +NNAG P S G++ + +N+L
Sbjct: 60 LCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTY 119
Query: 127 ICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE 186
T+ A +++ G++INI+S+ G +V Y ATK AVTA+T+ L L E
Sbjct: 120 TLTKLALPYLRK---SQGNVINISSLVGAIGQAQAVP--YVATKGAVTAMTKAL--ALDE 172
Query: 187 AQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQM------KCLKPEDVAEAVIYVL 240
+ +R CISPG + T +L P+ A E M + +P +V A +++
Sbjct: 173 SPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLA 232
Query: 241 S 241
S
Sbjct: 233 S 233
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 82.0 bits (201), Expect = 5e-16
Identities = 62/201 (30%), Positives = 96/201 (47%), Gaps = 10/201 (4%)
Query: 10 RDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAE--CKSAGYPGTLIPY 67
R+ + ++TGA+ G+G A+ G K+V C R G +EEL E A T PY
Sbjct: 51 RNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPY 110
Query: 68 --RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLAL 125
DL++ I++ + I VDI +NNAG++ T++ + K + N
Sbjct: 111 LVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGP 170
Query: 126 SICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELR 185
T+ SM +R GHI+ I+S+ G +P Y+A+K+A A + LR E+
Sbjct: 171 VALTKALLPSMIKRR--QGHIVAISSIQGKMSIPFRSA--YAASKHATQAFFDCLRAEME 226
Query: 186 EAQTHIRATCISPGVVETQFA 206
Q I T ISPG + T +
Sbjct: 227 --QYEIEVTVISPGYIHTNLS 245
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 80.5 bits (197), Expect = 1e-15
Identities = 69/260 (26%), Positives = 123/260 (47%), Gaps = 23/260 (8%)
Query: 1 MARPGMER---WRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKS 57
M+ G++R +R+A+VTG++ GIG A+AR L + G VV +R N++ A+ +
Sbjct: 23 MSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG 82
Query: 58 AGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSG---- 113
G ++ C + ED + + GVD + +AG+ L GST G
Sbjct: 83 EGL--SVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGV----NPLVGSTLGTSEQ 136
Query: 114 -WKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYA 172
W + +VNV + ++ + M+ R G +I ++S++ + P+ Y+ +K A
Sbjct: 137 IWDKILSVNVKSPALLLSQLLPYMENRR---GAVILVSSIAAYN--PVVALGVYNVSKTA 191
Query: 173 VTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDP--EKAAATYEQMKCLKPE 230
+ LT L EL A IR C+ PG+++T F+ H + + ++ + + E
Sbjct: 192 LLGLTRTLALEL--APKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESE 249
Query: 231 DVAEAVIYVLSTPAHIQIGD 250
D A V ++ S A G+
Sbjct: 250 DCAGIVSFLCSPDASYVNGE 269
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 80.1 bits (196), Expect = 2e-15
Identities = 63/243 (25%), Positives = 115/243 (47%), Gaps = 17/243 (6%)
Query: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70
D++ V G S GIG AVA+ + ++G ++ AR N+E A G G + + CD
Sbjct: 2 DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIAR---NLEGAKAAAGDLG--GDHLAFSCD 56
Query: 71 LSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTR 130
++ E D+ + F + V+ +N AG+ R L+ T + N+L + +
Sbjct: 57 VAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCK 116
Query: 131 EAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTH 190
A ++M ++ G I+N+ S+ G + S YSA+K + + L +E+ A+
Sbjct: 117 AAMRTMIQQ--QGGSIVNVGSIVG--LKGNSGQSVYSASKGGLVGFSRALAKEV--ARKK 170
Query: 191 IRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTP---AHIQ 247
IR ++PG V T L ++ +K + + +VA AV+++L +P H+
Sbjct: 171 IRVNVVAPGFVHTDMTKDLKEEHLKKNIPLGRFGETI---EVAHAVVFLLESPYITGHVL 227
Query: 248 IGD 250
+ D
Sbjct: 228 VVD 230
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 77.8 bits (190), Expect = 9e-15
Identities = 61/214 (28%), Positives = 106/214 (49%), Gaps = 21/214 (9%)
Query: 1 MARPGMER---WRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKS 57
M+ G++R +R+A+VTG++ GIG A+AR L + G VV +R N++ A+ +
Sbjct: 23 MSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQG 82
Query: 58 AGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSG---- 113
G ++ C + ED + + GVD + +AG+ L GST G
Sbjct: 83 EGL--SVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGV----NPLVGSTLGTSEQ 136
Query: 114 -WKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYA 172
W + +VNV + ++ + M+ R G +I ++S++ + P+ Y+ +K A
Sbjct: 137 IWDKILSVNVKSPALLLSQLLPYMENRR---GAVILVSSIAAYN--PVVALGVYNVSKTA 191
Query: 173 VTALTEGLRQELREAQTHIRATCISPGVVETQFA 206
+ LT L EL A IR C+ PG+++T F+
Sbjct: 192 LLGLTRTLALEL--APKDIRVNCVVPGIIKTDFS 223
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 77.4 bits (189), Expect = 1e-14
Identities = 72/247 (29%), Positives = 111/247 (44%), Gaps = 11/247 (4%)
Query: 1 MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGC----ARTVGNIEELAAECK 56
MA R R LALVTGA GIG AV+ L +G V C A + L
Sbjct: 1 MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGS 60
Query: 57 SAGYP-GTLIPYRCDLSNEEDILSMFSAIRSQHS-GVDICINNAGLARPDTLLSGSTSGW 114
G P G ++ D+S + +++ S + ++ AG+ + + LL S W
Sbjct: 61 KEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDW 120
Query: 115 KDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVT 174
+ VN+ + T+ A Q++ N G IINI+S+ G +V + T+ Y+A+K V
Sbjct: 121 DKVIAVNLKGTFLVTQAAAQALVS-NGCRGSIINISSIVG-KVGNVGQTN-YAASKAGVI 177
Query: 175 ALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAE 234
LT+ +EL + IR + PG + T K+ K +K PEDVA+
Sbjct: 178 GLTQTAAREL--GRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVAD 235
Query: 235 AVIYVLS 241
V ++ S
Sbjct: 236 VVAFLAS 242
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/197 (27%), Positives = 97/197 (49%), Gaps = 19/197 (9%)
Query: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSA----GYPGTLIPY 67
++ALVTGA+ GIG A A AL+ +G KV A N+ E +CK+A P +
Sbjct: 6 KVALVTGAAQGIGRAFAEALLLKGAKV---ALVDWNL-EAGVQCKAALDEQFEPQKTLFI 61
Query: 68 RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSI 127
+CD+++++ + F + +DI +NNAG+ + W+ +N++++
Sbjct: 62 QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVIS 113
Query: 128 CTREAYQSMKERNVDDGH-IININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE 186
T M ++N +G IIN++S++G ++P++ Y A+K+ + T
Sbjct: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAG--LMPVAQQPVYCASKHGIVGFTRSAALAANL 171
Query: 187 AQTHIRATCISPGVVET 203
+ +R I PG V T
Sbjct: 172 MNSGVRLNAICPGFVNT 188
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 73.9 bits (180), Expect = 1e-13
Identities = 66/247 (26%), Positives = 118/247 (47%), Gaps = 18/247 (7%)
Query: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGT----LIPY 67
++A+VTG + GIG A+ + L++ G VV +R + ++ A E + A P T +IP
Sbjct: 19 QVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQ-ANLPPTKQARVIPI 77
Query: 68 RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSI 127
+C++ NEE++ ++ + ++ +NN G S+ GW + N+
Sbjct: 78 QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFY 137
Query: 128 CTREAYQS-MKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE 186
+ Y S MKE G I+NI + PL+V A + V LT+ L L
Sbjct: 138 MCKAVYSSWMKEHG---GSIVNI-IVPTKAGFPLAV--HSGAARAGVYNLTKSL--ALEW 189
Query: 187 AQTHIRATCISPGVVETQFAFKLHDKDPEK-AAATYEQMKCLK---PEDVAEAVIYVLST 242
A + IR C++PGV+ +Q A + + + +++++ + PE+V+ V ++LS
Sbjct: 190 ACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSP 249
Query: 243 PAHIQIG 249
A G
Sbjct: 250 AASFITG 256
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 72.0 bits (175), Expect = 5e-13
Identities = 56/195 (28%), Positives = 92/195 (47%), Gaps = 7/195 (3%)
Query: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAG--YPGTLIPYR 68
D + VTGAS GIG +A L + G+ +V AR V +E + C G ++
Sbjct: 50 DMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLP 109
Query: 69 CDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSIC 128
DL++ + A+ + +DI +NN G+++ + S ++ + +N L
Sbjct: 110 LDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSL 169
Query: 129 TREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQ 188
T+ M ER G I+ +NS+ G +PLS+ Y A+K+A+ GLR EL
Sbjct: 170 TKCVLPHMIERK--QGKIVTVNSILGIISVPLSIG--YCASKHALRGFFNGLRTEL-ATY 224
Query: 189 THIRATCISPGVVET 203
I + I PG V++
Sbjct: 225 PGIIVSNICPGPVQS 239
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 71.6 bits (174), Expect = 6e-13
Identities = 68/241 (28%), Positives = 110/241 (45%), Gaps = 19/241 (7%)
Query: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDL 71
R LVTGA GIG +AL G +VV +RT +++ L EC PG + P DL
Sbjct: 8 RRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVREC-----PG-IEPVCVDL 61
Query: 72 SNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTRE 131
+ E ++ VD+ +NNA +A L + + F VN+ A+ ++
Sbjct: 62 GDWEATERALGSV----GPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQI 117
Query: 132 AYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHI 191
+ + R V G I+N++S R ++ Y +TK A+ LT+ + EL I
Sbjct: 118 VARGLIARGV-PGAIVNVSSQCSQRA--VTNHSVYCSTKGALDMLTKVMALEL--GPHKI 172
Query: 192 RATCISPGVVETQFAFKLHDKDPEKAAATYEQM---KCLKPEDVAEAVIYVLSTPAHIQI 248
R ++P VV T + DP KA ++ K + E V A++++LS + +
Sbjct: 173 RVNAVNPTVVMTSMG-QATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTT 231
Query: 249 G 249
G
Sbjct: 232 G 232
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 70.5 bits (171), Expect = 1e-12
Identities = 60/209 (28%), Positives = 110/209 (52%), Gaps = 21/209 (10%)
Query: 4 PGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGT 63
PG+ W A+VTG++ GIG + A L + G+KVV +R+ ++++++E K +
Sbjct: 47 PGLGEW----AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEK-FKVE 101
Query: 64 LIPYRCDLSNEEDILSMFSAIRSQHSGVD--ICINNAGLA--RPDTLLS--GSTSGWKDM 117
D ++E+ ++ I++ +G++ I +NN G++ P+ L + K M
Sbjct: 102 TRTIAVDFASED----IYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKM 157
Query: 118 FNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALT 177
N+N+L++ T+ M ER+ G I+NI+S SG +LP+ + YSATK V +
Sbjct: 158 ININILSVCKMTQLVLPGMVERS--KGAILNISSGSG--MLPVPLLTIYSATKTFVDFFS 213
Query: 178 EGLRQELREAQTHIRATCISPGVVETQFA 206
+ L +E R +++ + P V T+ A
Sbjct: 214 QCLHEEYRSKGVFVQS--VLPYFVATKLA 240
>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
[Homo sapiens]
Length = 281
Score = 70.5 bits (171), Expect = 1e-12
Identities = 73/265 (27%), Positives = 125/265 (47%), Gaps = 23/265 (8%)
Query: 1 MARPGMERWRD----RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECK 56
+A GM R RD ++ALVT ++ IG AVA+ L Q G VV R N+++ A +
Sbjct: 19 LASSGMTR-RDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQ 77
Query: 57 SAG--YPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPD----TLLSGS 110
G GT+ C + +D + + H +DI + ++ TLL +
Sbjct: 78 GEGLSMTGTV----CHVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTA 133
Query: 111 TSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATK 170
W ++N AL++ + M++R G + + S++ R PL Y+ +K
Sbjct: 134 EEAWDRNLDINGKALALMIKAVVPEMEKRG--GGSVGFLASVAAFR--PLPGFSPYNVSK 189
Query: 171 YAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKL-HDKDPEKAAATYEQMKCL-K 228
A+ L + L EL A +IR C++PG+++T F+ L DK+ E++ +++ L +
Sbjct: 190 TALLGLNKTLAIEL--APRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGE 247
Query: 229 PEDVAEAVIYVLSTPAHIQIGDIQM 253
PED V ++ S A G+ M
Sbjct: 248 PEDSLGIVSFLCSEDASYLTGETVM 272
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 69.7 bits (169), Expect = 2e-12
Identities = 69/253 (27%), Positives = 111/253 (43%), Gaps = 32/253 (12%)
Query: 12 RLALVTGASGGIGAAVARALVQQGLK---VVGCARTVGNIEELAAECKSAGYPGTLIPYR 68
R L++G S GIG +A L K VV R +G E L A A TL +
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEA-LGQTLTVAQ 64
Query: 69 CDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSIC 128
D+ ++E + S I+ + VD+ +NNAG+ L S + +++F+ N
Sbjct: 65 LDVCSDESVAQCLSCIQGE---VDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRL 121
Query: 129 TREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQ 188
+ MK R GHI+ I+S+ G + + Y+A+K+A+ E L +L Q
Sbjct: 122 VKAVLPGMKRRR--QGHIVVISSVMG--LQGVIFNDVYAASKFALEGFFESLAIQL--LQ 175
Query: 189 THIRATCISPGVVETQFAFKL---------HDKDPEKA-------AATYEQMKC---LKP 229
+I + + PG V T+F KL DPE ++ C P
Sbjct: 176 FNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNP 235
Query: 230 EDVAEAVIYVLST 242
+DV +A++ V+S+
Sbjct: 236 QDVVQAIVNVISS 248
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 66.6 bits (161), Expect = 2e-11
Identities = 48/171 (28%), Positives = 89/171 (52%), Gaps = 19/171 (11%)
Query: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSA----GYPGTLIPY 67
++ALVTGA+ GIG A A AL+ +G KV A N+ E +CK+A P +
Sbjct: 6 KVALVTGAAQGIGRAFAEALLLKGAKV---ALVDWNL-EAGVQCKAALDEQFEPQKTLFI 61
Query: 68 RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSI 127
+CD+++++ + F + +DI +NNAG+ + W+ +N++++
Sbjct: 62 QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVIS 113
Query: 128 CTREAYQSMKERNVDDGH-IININSMSGHRVLPLSVTHFYSATKYAVTALT 177
T M ++N +G IIN++S++G ++P++ Y A+K+ + T
Sbjct: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAG--LMPVAQQPVYCASKHGIVGFT 162
>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
[Homo sapiens]
Length = 264
Score = 65.1 bits (157), Expect = 6e-11
Identities = 42/130 (32%), Positives = 63/130 (48%), Gaps = 5/130 (3%)
Query: 77 ILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSM 136
+L + ++ + V I +NNAG P LLS F VN+L T+ SM
Sbjct: 64 VLWDINKVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSM 123
Query: 137 KERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE-AQTHIRATC 195
ERN GHI+ + S+ GH +P + Y ++K+A GL EL+ +T I+ +C
Sbjct: 124 MERN--HGHIVTVASVCGHEGIPYLIP--YCSSKFAAVGFHRGLTSELQALGKTGIKTSC 179
Query: 196 ISPGVVETQF 205
+ P V T F
Sbjct: 180 LCPVFVNTGF 189
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 63.5 bits (153), Expect = 2e-10
Identities = 58/220 (26%), Positives = 98/220 (44%), Gaps = 24/220 (10%)
Query: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70
D+ +TG G G AR ++G V+ T L AE L D
Sbjct: 29 DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE-----RLRTVLLD 83
Query: 71 LSNEEDILSMFSAIRSQ--HSGVDICINNAG----LARPDTLLSGSTSGWKDMFNVNVLA 124
+++ E++ +++Q G+ INNAG LA D L + +++ VN+
Sbjct: 84 VTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL---TLEDYREPIEVNLFG 140
Query: 125 LSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQEL 184
L T +K+ G +IN++S+ G + V Y+ +KYAV + LR+++
Sbjct: 141 LISVTLNMLPLVKKA---QGRVINVSSVGGRLAI---VGGGYTPSKYAVEGFNDSLRRDM 194
Query: 185 REAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQM 224
+ H+ +CI PG+ +T A + K EK A +EQ+
Sbjct: 195 KAFGVHV--SCIEPGLFKTNLADPV--KVIEKKLAIWEQL 230
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 63.5 bits (153), Expect = 2e-10
Identities = 58/220 (26%), Positives = 98/220 (44%), Gaps = 24/220 (10%)
Query: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70
D+ +TG G G AR ++G V+ T L AE L D
Sbjct: 29 DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE-----RLRTVLLD 83
Query: 71 LSNEEDILSMFSAIRSQ--HSGVDICINNAG----LARPDTLLSGSTSGWKDMFNVNVLA 124
+++ E++ +++Q G+ INNAG LA D L + +++ VN+
Sbjct: 84 VTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL---TLEDYREPIEVNLFG 140
Query: 125 LSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQEL 184
L T +K+ G +IN++S+ G + V Y+ +KYAV + LR+++
Sbjct: 141 LISVTLNMLPLVKKA---QGRVINVSSVGGRLAI---VGGGYTPSKYAVEGFNDSLRRDM 194
Query: 185 REAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQM 224
+ H+ +CI PG+ +T A + K EK A +EQ+
Sbjct: 195 KAFGVHV--SCIEPGLFKTNLADPV--KVIEKKLAIWEQL 230
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 63.5 bits (153), Expect = 2e-10
Identities = 58/220 (26%), Positives = 98/220 (44%), Gaps = 24/220 (10%)
Query: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70
D+ +TG G G AR ++G V+ T L AE L D
Sbjct: 29 DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE-----RLRTVLLD 83
Query: 71 LSNEEDILSMFSAIRSQ--HSGVDICINNAG----LARPDTLLSGSTSGWKDMFNVNVLA 124
+++ E++ +++Q G+ INNAG LA D L + +++ VN+
Sbjct: 84 VTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL---TLEDYREPIEVNLFG 140
Query: 125 LSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQEL 184
L T +K+ G +IN++S+ G + V Y+ +KYAV + LR+++
Sbjct: 141 LISVTLNMLPLVKKA---QGRVINVSSVGGRLAI---VGGGYTPSKYAVEGFNDSLRRDM 194
Query: 185 REAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQM 224
+ H+ +CI PG+ +T A + K EK A +EQ+
Sbjct: 195 KAFGVHV--SCIEPGLFKTNLADPV--KVIEKKLAIWEQL 230
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 63.5 bits (153), Expect = 2e-10
Identities = 58/220 (26%), Positives = 98/220 (44%), Gaps = 24/220 (10%)
Query: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70
D+ +TG G G AR ++G V+ T L AE L D
Sbjct: 29 DKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE-----RLRTVLLD 83
Query: 71 LSNEEDILSMFSAIRSQ--HSGVDICINNAG----LARPDTLLSGSTSGWKDMFNVNVLA 124
+++ E++ +++Q G+ INNAG LA D L + +++ VN+
Sbjct: 84 VTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWL---TLEDYREPIEVNLFG 140
Query: 125 LSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQEL 184
L T +K+ G +IN++S+ G + V Y+ +KYAV + LR+++
Sbjct: 141 LISVTLNMLPLVKKA---QGRVINVSSVGGRLAI---VGGGYTPSKYAVEGFNDSLRRDM 194
Query: 185 REAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQM 224
+ H+ +CI PG+ +T A + K EK A +EQ+
Sbjct: 195 KAFGVHV--SCIEPGLFKTNLADPV--KVIEKKLAIWEQL 230
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 63.2 bits (152), Expect = 2e-10
Identities = 52/190 (27%), Positives = 92/190 (48%), Gaps = 15/190 (7%)
Query: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAG--YPGTLIPYR 68
+++ALVT ++ GIG A+AR L Q VV +R N+++ A + G GT+
Sbjct: 32 NKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTV---- 87
Query: 69 CDLSNEEDILSMFSAIRSQHSGVDICINNAGLARP--DTLLSGSTSGWKDMFNVNVLALS 126
C + ED + + H G+DI ++NA + P +L+ + W ++NV A +
Sbjct: 88 CHVGKAEDRERLVAMAVKLHGGIDILVSNAAV-NPFFGSLMDVTEEVWDKTLDINVKAPA 146
Query: 127 ICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE 186
+ T+ M++R G ++ ++S++ P Y+ +K A+ L L EL
Sbjct: 147 LMTKAVVPEMEKRG--GGSVVIVSSIAAFS--PSPGFSPYNVSKTALLGLNNTLAIEL-- 200
Query: 187 AQTHIRATCI 196
A +IR C+
Sbjct: 201 APRNIRVNCL 210
>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
sapiens]
Length = 330
Score = 62.8 bits (151), Expect = 3e-10
Identities = 49/206 (23%), Positives = 91/206 (44%), Gaps = 16/206 (7%)
Query: 11 DRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCD 70
DR+A+VTG + GIG + A+ L + G+ V+ +++ ++ K + CD
Sbjct: 43 DRVAIVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCD 102
Query: 71 LSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTR 130
L++ I + + + + INNAG+ + G+++ F +N L + T
Sbjct: 103 LASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQ--RKTRDGFEEHFGLNYLGHFLLTN 160
Query: 131 EAYQSMKERNVDDGHIININSMSG--HRVLPLSVTHF-----------YSATKYAVTALT 177
++KE GH + ++S H V L++ Y+ +K A+ T
Sbjct: 161 LLLDTLKESG-SPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFT 219
Query: 178 EGLRQELREAQTHIRATCISPGVVET 203
L++ L +H+ A + PGVV T
Sbjct: 220 YHLQRLLAAEGSHVTANVVDPGVVNT 245
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 62.8 bits (151), Expect = 3e-10
Identities = 57/226 (25%), Positives = 101/226 (44%), Gaps = 9/226 (3%)
Query: 15 LVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECK--SAGYPGTLIPYRCDLS 72
+VTG S GIG +A +QG + AR + + E + S ++ D+S
Sbjct: 36 VVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVS 95
Query: 73 NE-EDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTRE 131
+ + ++ + + VD+ +N AG+A S ++ + ++N L +R
Sbjct: 96 QDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRA 155
Query: 132 AYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHI 191
+MKER V G I+ ++S +G L L YSA+K+A+ L E L+ E++ +I
Sbjct: 156 VITTMKERRV--GRIVFVSSQAGQ--LGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYI 211
Query: 192 RATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVI 237
T P +T + + P + E KPE VA+ ++
Sbjct: 212 --TVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIV 255
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 62.8 bits (151), Expect = 3e-10
Identities = 53/198 (26%), Positives = 90/198 (45%), Gaps = 16/198 (8%)
Query: 6 MERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLI 65
M R ++ ++T A+ GIG A A A ++G KV+ ++EL YPG +
Sbjct: 1 MGRLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELEK------YPG-IQ 53
Query: 66 PYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLAL 125
D++ ++ I ++ +D+ N AG T+L W N+NV ++
Sbjct: 54 TRVLDVTKKKQI----DQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSM 109
Query: 126 SICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELR 185
+ + M + G+IIN++S++ V + YS TK AV LT+ + +
Sbjct: 110 YLMIKAFLPKMLAQK--SGNIINMSSVAS-SVKGVVNRCVYSTTKAAVIGLTKSVAADF- 165
Query: 186 EAQTHIRATCISPGVVET 203
Q IR C+ PG V+T
Sbjct: 166 -IQQGIRCNCVCPGTVDT 182
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 61.6 bits (148), Expect = 7e-10
Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 23/204 (11%)
Query: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDL 71
++ +VTGAS GIG +A L + G V R + + +A E +S G G +P CD
Sbjct: 8 QVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLG--GQCVPVVCDS 65
Query: 72 SNEEDILSMFSAI-RSQHSGVDICINNAGLARPDTLLS--------GSTSGWKDMFNVNV 122
S E ++ S+F + R Q +D+ +NNA A T+L+ S W D+ NV +
Sbjct: 66 SQESEVRSLFEQVDREQQGRLDVLVNNA-YAGVQTILNTRNKAFWETPASMWDDINNVGL 124
Query: 123 LALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQ 182
C+ Y + G I+ I+S L Y K A L
Sbjct: 125 RGHYFCS--VYGARLMVPAGQGLIVVISSPGS---LQYMFNVPYGVGKAACDKLAADCAH 179
Query: 183 ELREAQTHIRATCIS--PGVVETQ 204
ELR +C+S PG+V+T+
Sbjct: 180 ELRRH----GVSCVSLWPGIVQTE 199
>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 61.6 bits (148), Expect = 7e-10
Identities = 59/204 (28%), Positives = 89/204 (43%), Gaps = 23/204 (11%)
Query: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDL 71
++ +VTGAS GIG +A L + G V R + + +A E +S G G +P CD
Sbjct: 8 QVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRVVAQEAQSLG--GQCVPVVCDS 65
Query: 72 SNEEDILSMFSAI-RSQHSGVDICINNAGLARPDTLLS--------GSTSGWKDMFNVNV 122
S E ++ S+F + R Q +D+ +NNA A T+L+ S W D+ NV +
Sbjct: 66 SQESEVRSLFEQVDREQQGRLDVLVNNA-YAGVQTILNTRNKAFWETPASMWDDINNVGL 124
Query: 123 LALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQ 182
C+ Y + G I+ I+S L Y K A L
Sbjct: 125 RGHYFCS--VYGARLMVPAGQGLIVVISSPGS---LQYMFNVPYGVGKAACDKLAADCAH 179
Query: 183 ELREAQTHIRATCIS--PGVVETQ 204
ELR +C+S PG+V+T+
Sbjct: 180 ELRRH----GVSCVSLWPGIVQTE 199
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 61.2 bits (147), Expect = 9e-10
Identities = 55/224 (24%), Positives = 94/224 (41%), Gaps = 15/224 (6%)
Query: 15 LVTGASGGIGAAVARALVQQGL-KVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSN 73
L+TG GIG +AR ++G K+V RT ++E E + G + CD+ N
Sbjct: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHY--FICDVGN 99
Query: 74 EEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAY 133
E++ A+R + + I +NNA + +L+ ++N L T+
Sbjct: 100 REEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFL 159
Query: 134 QSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRA 193
M E + +GHI+ +NS+ +P ++ Y +K + A E L L + + A
Sbjct: 160 PRMLE--LQNGHIVCLNSVLALSAIPGAID--YCTSKASAFAFMESLTLGLLDC-PGVSA 214
Query: 194 TCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVI 237
T + P T+ + + P LKPE VA +
Sbjct: 215 TTVLPFHTSTEMFQGMRVRFP-------NLFPPLKPETVARRTV 251
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,461,257
Number of Sequences: 37866
Number of extensions: 362409
Number of successful extensions: 885
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 771
Number of HSP's gapped (non-prelim): 79
length of query: 260
length of database: 18,247,518
effective HSP length: 100
effective length of query: 160
effective length of database: 14,460,918
effective search space: 2313746880
effective search space used: 2313746880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.