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Search of human proteins with 109659849
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109659849 filamin A interacting protein 1-like isoform 2
[Homo sapiens]
(893 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 1739 0.0
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom... 1739 0.0
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 1729 0.0
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 741 0.0
gi|216548091 leucine zipper protein 1 [Homo sapiens] 259 8e-69
gi|216548085 leucine zipper protein 1 [Homo sapiens] 259 8e-69
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 114 4e-25
gi|71061468 centromere protein E [Homo sapiens] 112 1e-24
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 112 2e-24
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 112 2e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 111 3e-24
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 111 3e-24
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 111 3e-24
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 111 3e-24
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 111 3e-24
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 110 8e-24
gi|45439327 periplakin [Homo sapiens] 110 8e-24
gi|28416946 myosin 18A isoform a [Homo sapiens] 109 1e-23
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 109 1e-23
gi|38044112 restin isoform b [Homo sapiens] 108 2e-23
gi|4506751 restin isoform a [Homo sapiens] 108 2e-23
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 108 3e-23
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 108 3e-23
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 107 6e-23
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 106 8e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 106 8e-23
gi|156104908 myosin heavy chain 6 [Homo sapiens] 105 1e-22
gi|42794779 myosin 18A isoform b [Homo sapiens] 103 5e-22
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 103 9e-22
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 102 1e-21
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 1739 bits (4504), Expect = 0.0
Identities = 893/893 (100%), Positives = 893/893 (100%)
Query: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
Query: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 301 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
Query: 121 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 361 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
Query: 181 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240
SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
Query: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 481 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360
EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 541 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
Query: 361 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
Query: 421 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 480
RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 661 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
Query: 481 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 540
ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 721 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
Query: 541 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 600
LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 781 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
Query: 601 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 660
EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 841 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
Query: 661 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 720
PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
Query: 721 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 780
TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
Query: 781 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 840
EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
Query: 841 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN 893
ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN
Sbjct: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN 1133
Score = 103 bits (258), Expect = 5e-22
Identities = 103/427 (24%), Positives = 197/427 (46%), Gaps = 24/427 (5%)
Query: 76 EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 135
ED L L+ L ++ +E L+ + +L + + +YG +E L
Sbjct: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLA-----LLEAQYGFVTPKKVLEAL 119
Query: 136 RKRVLDMEGKDEELIKMEEQCRDLNKRLER--ETLQSKDFKLEVEKLSKRIMALEKLEDA 193
++ + + E+ +L+K +E+ E+ + +L V + S+R LE LE+
Sbjct: 120 QRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILE-LEEE 178
Query: 194 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKV----RIKELEAIESRLEKTEFTLKED 249
K K+ +EK L QE E LK IK E E EK TLKE+
Sbjct: 179 KRKHKEY-------MEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEE 231
Query: 250 LTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKS 309
LTKLK+ +M VDE++ ++ +L K+Q ++ + K+ ++ EE ++A +
Sbjct: 232 LTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRL 291
Query: 310 KTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQ 369
+ +++ + +++D + KL E+ + L ++ L ++ LE + K +
Sbjct: 292 EKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
Query: 370 DSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDK 429
K + + N + EVE L+ ++ DM+ +++L+K E++ L +R E +
Sbjct: 352 QDIKEKISKGEYGN--AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ 409
Query: 430 AQFLSKELEHV-KMELAKYKLAEKTETSHEQW--LFKRLQEEEAKSGHLSREVDALKEKI 486
++ E+E + K +A KL + S ++ L L++E + LS+E+++LK +I
Sbjct: 410 SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI 469
Query: 487 HEYMATE 493
E A E
Sbjct: 470 KELEAIE 476
>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
sapiens]
Length = 893
Score = 1739 bits (4504), Expect = 0.0
Identities = 893/893 (100%), Positives = 893/893 (100%)
Query: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
Query: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
Query: 121 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 121 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
Query: 181 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240
SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 181 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240
Query: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
Query: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360
EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360
Query: 361 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 361 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
Query: 421 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 480
RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 421 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 480
Query: 481 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 540
ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 481 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 540
Query: 541 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 600
LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 541 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 600
Query: 601 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 660
EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 601 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 660
Query: 661 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 720
PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 661 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 720
Query: 721 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 780
TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 721 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 780
Query: 781 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 840
EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 781 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 840
Query: 841 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN 893
ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN
Sbjct: 841 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVSNIYN 893
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 1729 bits (4477), Expect = 0.0
Identities = 888/888 (100%), Positives = 888/888 (100%)
Query: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
Query: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 301 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
Query: 121 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 361 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
Query: 181 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240
SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
Query: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 481 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360
EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 541 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
Query: 361 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
Query: 421 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 480
RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 661 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
Query: 481 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 540
ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 721 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
Query: 541 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 600
LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 781 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
Query: 601 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 660
EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 841 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
Query: 661 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 720
PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
Query: 721 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 780
TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
Query: 781 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 840
EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
Query: 841 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV 888
ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV
Sbjct: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV 1128
Score = 103 bits (258), Expect = 5e-22
Identities = 103/427 (24%), Positives = 197/427 (46%), Gaps = 24/427 (5%)
Query: 76 EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 135
ED L L+ L ++ +E L+ + +L + + +YG +E L
Sbjct: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLA-----LLEAQYGFVTPKKVLEAL 119
Query: 136 RKRVLDMEGKDEELIKMEEQCRDLNKRLER--ETLQSKDFKLEVEKLSKRIMALEKLEDA 193
++ + + E+ +L+K +E+ E+ + +L V + S+R LE LE+
Sbjct: 120 QRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILE-LEEE 178
Query: 194 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKV----RIKELEAIESRLEKTEFTLKED 249
K K+ +EK L QE E LK IK E E EK TLKE+
Sbjct: 179 KRKHKEY-------MEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEE 231
Query: 250 LTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKS 309
LTKLK+ +M VDE++ ++ +L K+Q ++ + K+ ++ EE ++A +
Sbjct: 232 LTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRL 291
Query: 310 KTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQ 369
+ +++ + +++D + KL E+ + L ++ L ++ LE + K +
Sbjct: 292 EKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
Query: 370 DSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDK 429
K + + N + EVE L+ ++ DM+ +++L+K E++ L +R E +
Sbjct: 352 QDIKEKISKGEYGN--AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ 409
Query: 430 AQFLSKELEHV-KMELAKYKLAEKTETSHEQW--LFKRLQEEEAKSGHLSREVDALKEKI 486
++ E+E + K +A KL + S ++ L L++E + LS+E+++LK +I
Sbjct: 410 SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI 469
Query: 487 HEYMATE 493
E A E
Sbjct: 470 KELEAIE 476
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 741 bits (1914), Expect = 0.0
Identities = 416/903 (46%), Positives = 596/903 (66%), Gaps = 26/903 (2%)
Query: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
M+VDE+Q QL LQ QK+Q+LT +E KL ++ +E+ QK +LE + + + +
Sbjct: 249 MLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKAS 308
Query: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
+F Q+ + + AKL N++S NRQL+ KL L+++I+ELEETN++L+KAEEELQ++++KI+K
Sbjct: 309 RFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAK 368
Query: 121 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
GE GN+ +MAEVE LRKRVL+MEGKDEE+ K E QCR+L K+L+ E SK+ +LEVEKL
Sbjct: 369 GECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKL 428
Query: 181 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240
KR+ LEKLE+AF+KSK EC L NLEKE+ TK L ELE +K R+KELE ESRLE
Sbjct: 429 QKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLE 488
Query: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
K E +LK+DLTKLK+ TVM VDERK M EK+K+ E K+ + +VEQ KV VTEKLI
Sbjct: 489 KAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLI 548
Query: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360
EE+K+ LK K+++EEK+Y++T+ERD+L KLK+EEEK ++L V++LK RL +E +E+
Sbjct: 549 EESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVER 608
Query: 361 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
+ + + S K + E+NKIKEL+ E+ERLK +L+ ++ +E DLMKTEDEY+ LE
Sbjct: 609 EITRGR----SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLE 664
Query: 421 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTE-TSHEQWLFKRLQEEEAKSGHLSREV 479
+++ E+DKA FLS++LE +K ++AK K EK E S E L R + EEAKS L EV
Sbjct: 665 QKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEV 724
Query: 480 DALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSK 539
ALKEKIHE M ED + LQ D+SVLQ++ ++EN+N+++G+E+ NLTKELE + +S+
Sbjct: 725 QALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSR 784
Query: 540 SLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQD---E 596
+LRPS+NGRR+ D V S VQT+AV E + ++ R + + S + +
Sbjct: 785 ALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLK 844
Query: 597 DPNDEGSVLSFKCSQSTPCPVNRKLWIPWMKSKE-GHLQNGKMQTKPNANFVQPGDLVLS 655
P + SVL + + RK WIPWM+ +E G + + N++ PG++VLS
Sbjct: 845 KPVERSSVLDRYPPAANELTM-RKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLS 903
Query: 656 HTPGQPLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASIT 715
GQPLHI+VTPDH +TATLEITSPT+E ++ST VIP G K RITI+ + ++
Sbjct: 904 PKQGQPLHIRVTPDHENSTATLEITSPTSE--EFFSSTTVIPTLGNQKPRITIIPSPNVM 961
Query: 716 PVKSKTSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPE 775
P K K S + + E+ MSP+T+ TF+R +TPES +R SPIQ++ V+ SA+ E
Sbjct: 962 PQKQK-SGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAE 1020
Query: 776 QGRSPEPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVA 835
SPE E+ I +V+P++Q+ R ++++++ITTEDNKIHIHLGS + ++
Sbjct: 1021 IAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPG 1080
Query: 836 SP---VRPASPSAPLQDNRTQGLINGALNKT----------TNKVTSSITITPTATPLPR 882
+ V P P+ + + G + ++ +KVTS+ITITP T R
Sbjct: 1081 TSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSAR 1140
Query: 883 QSQ 885
+Q
Sbjct: 1141 GTQ 1143
Score = 112 bits (279), Expect = 2e-24
Identities = 115/473 (24%), Positives = 218/473 (46%), Gaps = 47/473 (9%)
Query: 43 EEEQKATRLEKELQTQ-TTKFHQDQDTIMAKLTNEDSQ--NRQLQQKLAALSRQIDELEE 99
++++K+ R E ++ T K H + T + + L Q L+ + ++ E+
Sbjct: 37 KKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQARED 96
Query: 100 TNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL-RKRVLDME---GKD------EEL 149
L+ + K ++ + YG+A + L R +L E G+D EL
Sbjct: 97 VIHMLKT-----EKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISEL 151
Query: 150 IKMEEQCRDLNKRLERETLQSKD------FKLEVEKLSKRIMALEKLEDAFNKSKQECYS 203
++EE+ ++ +R+ + L ++ ++LE EK K + K +D N +QE
Sbjct: 152 DRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEK-HKHTDYMNKSDDFTNLLEQERER 210
Query: 204 LKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDE 263
LK LE+E+ Q +E E+ K RL K L+++L KLK+ +M VDE
Sbjct: 211 LKKLLEQEK--AYQARKEKENAK-----------RLNK----LRDELVKLKSFALMLVDE 253
Query: 264 RKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKE 323
R+ E+L K+Q + +L+ E+ K+ +T K E+ ++ LK + D E K ++E
Sbjct: 254 RQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQE 313
Query: 324 RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENN 383
+++ KL +E L ++ L R++ LE K+ K + + A + N
Sbjct: 314 HEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGN 373
Query: 384 KIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVK-- 441
L EVE L+ ++ +M+ ++++ KTE + L ++ E ++ L E+E ++
Sbjct: 374 --SSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKR 431
Query: 442 -MELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATE 493
EL K + A S L L++E+ + L E++ +K ++ E +E
Sbjct: 432 MSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSE 484
>gi|216548091 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 259 bits (662), Expect = 8e-69
Identities = 152/423 (35%), Positives = 262/423 (61%), Gaps = 43/423 (10%)
Query: 70 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 127
MA+ T+ E + +R L+ KL +LSR++DELEE ++L+KAE+EL D+++K+ + E N+
Sbjct: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
Query: 128 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 187
++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E +++ K E+E+L KR+ L
Sbjct: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
Query: 188 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 247
EKLE+AF++SK +C L +L +ER TK++S ELE L+V++KELE+ E RL+KTE +L
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
Query: 248 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 307
+L KLK+LT+ FV ERK ++EK K+ E ++ + +L EQNK + +
Sbjct: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------KMNRDYT 229
Query: 308 KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 367
++ +++E +N L+ E+ + L S+ + K L L+ +E + +NK
Sbjct: 230 RNASNLE-------------RNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKS 275
Query: 368 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER 427
+ + +QE+NK+K+L+QE+E+LK ++K +++E++L K + + L+ Y +E+
Sbjct: 276 ENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQ 330
Query: 428 DKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHLS 476
+K + L+ +LE +K+++ K K E E HE+ F+ E + S H +
Sbjct: 331 NKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTA 390
Query: 477 REV 479
RE+
Sbjct: 391 REL 393
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)
Query: 210 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 269
KE +++ L +L+SL R+ ELE L+K E DE + +
Sbjct: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
Query: 270 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 329
K+ + E + ++++V + +V + K EE KRA E + + KE
Sbjct: 50 KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
Query: 330 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 389
KL+ EE +L S + L+ R+ LE +E+ F ++K D + +L++E N K++S
Sbjct: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
Query: 390 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 436
E+E L++K+K++++ ED L KTE E E L ER+Y NE++K K
Sbjct: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
Query: 437 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 495
++ + +L + K + T + L + L+ E+ S L + K + E+
Sbjct: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
Query: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 555
+ S +K NQ++N+ +DL +EIE L +++ + + L+ +
Sbjct: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
Query: 556 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 590
S++ + + + ++ + K I ++ + NG++ E
Sbjct: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
Score = 70.5 bits (171), Expect = 7e-12
Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)
Query: 274 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 333
T K A+S L+ + ++ ++L E TK K++ ++ DL++K+
Sbjct: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
Query: 334 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 392
E + +L+ + +L+ R+ +E +++ K +D + L +E N +EL E+
Sbjct: 54 AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
Query: 393 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 452
ERL+ ++ +++ +E+ +++++ L ER+ + +S ELE +++++ + + +E
Sbjct: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
Query: 453 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 512
EQ L L++ ++ + E L EK E E LI L +KL Q
Sbjct: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
Query: 513 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 549
+ NRD R NL + R S PS RR
Sbjct: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
Score = 69.7 bits (169), Expect = 1e-11
Identities = 82/360 (22%), Positives = 159/360 (44%), Gaps = 39/360 (10%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
+E +R L ++K++E +E +++ + R+ E E+ L+ ++
Sbjct: 80 EEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK--------LEEAFSRSK 131
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
D + L E + +++ +L L ++ ELE + L K E+ L EK+
Sbjct: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK---- 187
Query: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------TLQSKDFKLE- 176
+ RK + + E ++E+LIK Q + NK++ R+ L+ D ++E
Sbjct: 188 ---SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
Query: 177 ------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
K S+R L+ L+ N+++ + + K N +E K L+QE+E LK +IK
Sbjct: 245 GISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLNQEIEKLKTQIK 303
Query: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDKLQAASSQLQVE 288
E++E L+K +K L+ + ++ K ++ +L+ K + K Q +VE
Sbjct: 304 HFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
Query: 289 QNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKAEEEKGNDLLSR 344
++ E TK R S+ V + + S +R+ L+N+ A + L +R
Sbjct: 360 GEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNR 419
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/342 (20%), Positives = 136/342 (39%), Gaps = 71/342 (20%)
Query: 12 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 71
QL L + + LT K+ ++L + +V+E E RL+K Q+ ++ + + ++
Sbjct: 136 QLCLSLNEERNLT---KKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLS 192
Query: 72 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 131
++ N + ++ + +LE+ + R +++ + E G + +
Sbjct: 193 FVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPS 252
Query: 132 VEELRKRVLDMEGKDEELIKMEEQCRDLN---KRLERETLQSKDFKLEVEKLSKRIMALE 188
E RK LD L ++E + R+ + K +E + KD E+EKL +I E
Sbjct: 253 KESRRKGGLDY------LKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
Query: 189 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES----------- 237
LE+ K K + L+ N E+ K L+ +LE +K++IK+ + +E+
Sbjct: 307 SLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS 366
Query: 238 ----------------------------------RLEKTEFTLKED---LTKLKTLTVMF 260
RL EF L + L+ + + F
Sbjct: 367 SKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSF 426
Query: 261 VDERKTMS-----------EKLKKTEDKLQAASSQLQVEQNK 291
+ R + ++ KKTED+ SSQ + ++++
Sbjct: 427 TNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
>gi|216548085 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 259 bits (662), Expect = 8e-69
Identities = 152/423 (35%), Positives = 262/423 (61%), Gaps = 43/423 (10%)
Query: 70 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 127
MA+ T+ E + +R L+ KL +LSR++DELEE ++L+KAE+EL D+++K+ + E N+
Sbjct: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
Query: 128 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 187
++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E +++ K E+E+L KR+ L
Sbjct: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
Query: 188 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 247
EKLE+AF++SK +C L +L +ER TK++S ELE L+V++KELE+ E RL+KTE +L
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
Query: 248 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 307
+L KLK+LT+ FV ERK ++EK K+ E ++ + +L EQNK + +
Sbjct: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------KMNRDYT 229
Query: 308 KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 367
++ +++E +N L+ E+ + L S+ + K L L+ +E + +NK
Sbjct: 230 RNASNLE-------------RNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKS 275
Query: 368 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER 427
+ + +QE+NK+K+L+QE+E+LK ++K +++E++L K + + L+ Y +E+
Sbjct: 276 ENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQ 330
Query: 428 DKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHLS 476
+K + L+ +LE +K+++ K K E E HE+ F+ E + S H +
Sbjct: 331 NKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTA 390
Query: 477 REV 479
RE+
Sbjct: 391 REL 393
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)
Query: 210 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 269
KE +++ L +L+SL R+ ELE L+K E DE + +
Sbjct: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
Query: 270 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 329
K+ + E + ++++V + +V + K EE KRA E + + KE
Sbjct: 50 KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
Query: 330 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 389
KL+ EE +L S + L+ R+ LE +E+ F ++K D + +L++E N K++S
Sbjct: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
Query: 390 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 436
E+E L++K+K++++ ED L KTE E E L ER+Y NE++K K
Sbjct: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
Query: 437 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 495
++ + +L + K + T + L + L+ E+ S L + K + E+
Sbjct: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
Query: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 555
+ S +K NQ++N+ +DL +EIE L +++ + + L+ +
Sbjct: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
Query: 556 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 590
S++ + + + ++ + K I ++ + NG++ E
Sbjct: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
Score = 70.5 bits (171), Expect = 7e-12
Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)
Query: 274 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 333
T K A+S L+ + ++ ++L E TK K++ ++ DL++K+
Sbjct: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
Query: 334 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 392
E + +L+ + +L+ R+ +E +++ K +D + L +E N +EL E+
Sbjct: 54 AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
Query: 393 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 452
ERL+ ++ +++ +E+ +++++ L ER+ + +S ELE +++++ + + +E
Sbjct: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
Query: 453 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 512
EQ L L++ ++ + E L EK E E LI L +KL Q
Sbjct: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
Query: 513 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 549
+ NRD R NL + R S PS RR
Sbjct: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
Score = 69.7 bits (169), Expect = 1e-11
Identities = 82/360 (22%), Positives = 159/360 (44%), Gaps = 39/360 (10%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
+E +R L ++K++E +E +++ + R+ E E+ L+ ++
Sbjct: 80 EEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEK--------LEEAFSRSK 131
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
D + L E + +++ +L L ++ ELE + L K E+ L EK+
Sbjct: 132 NDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK---- 187
Query: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------TLQSKDFKLE- 176
+ RK + + E ++E+LIK Q + NK++ R+ L+ D ++E
Sbjct: 188 ---SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIED 244
Query: 177 ------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
K S+R L+ L+ N+++ + + K N +E K L+QE+E LK +IK
Sbjct: 245 GISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLNQEIEKLKTQIK 303
Query: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDKLQAASSQLQVE 288
E++E L+K +K L+ + ++ K ++ +L+ K + K Q +VE
Sbjct: 304 HFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVE 359
Query: 289 QNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKAEEEKGNDLLSR 344
++ E TK R S+ V + + S +R+ L+N+ A + L +R
Sbjct: 360 GEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNR 419
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/342 (20%), Positives = 136/342 (39%), Gaps = 71/342 (20%)
Query: 12 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 71
QL L + + LT K+ ++L + +V+E E RL+K Q+ ++ + + ++
Sbjct: 136 QLCLSLNEERNLT---KKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLS 192
Query: 72 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 131
++ N + ++ + +LE+ + R +++ + E G + +
Sbjct: 193 FVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPS 252
Query: 132 VEELRKRVLDMEGKDEELIKMEEQCRDLN---KRLERETLQSKDFKLEVEKLSKRIMALE 188
E RK LD L ++E + R+ + K +E + KD E+EKL +I E
Sbjct: 253 KESRRKGGLDY------LKQVENETRNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFE 306
Query: 189 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES----------- 237
LE+ K K + L+ N E+ K L+ +LE +K++IK+ + +E+
Sbjct: 307 SLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLS 366
Query: 238 ----------------------------------RLEKTEFTLKED---LTKLKTLTVMF 260
RL EF L + L+ + + F
Sbjct: 367 SKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENYSLSNRQVSSPSF 426
Query: 261 VDERKTMS-----------EKLKKTEDKLQAASSQLQVEQNK 291
+ R + ++ KKTED+ SSQ + ++++
Sbjct: 427 TNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 114 bits (285), Expect = 4e-25
Identities = 136/617 (22%), Positives = 273/617 (44%), Gaps = 92/617 (14%)
Query: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK---ELQT 57
++ D ++QL + +K + L + ++ E R+++EE+ LEK +L
Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 58 QTTKFHQDQDTIMAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLR----------K 106
+TT + A++ Q + +++L AL+R DE N +L+ +
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKR 162
+E+ + K +K E + E+E L+ + LD +EL K E++ +L K
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Query: 163 LERETLQSKDFKLEVEKLSKR-IMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE 221
LE ET K+ + +++ + +R ALE+L + ++K+ K NLEK + + L +
Sbjct: 1183 LEEET---KNHEAQIQDMRQRHATALEELSEQLEQAKR----FKANLEKNK---QGLETD 1232
Query: 222 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 281
+ L +K L+ +++ E L + +L R ++EK K +++L
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 282 SSQLQ------VEQNKVTTVTEKLIEETKRALKSKT----DVEEKMYSVTKERDDLKNKL 331
S+ L+ ++ K E +++T+ L+ +T ++ ++ + +E++ L+ +
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 332 KAEEEKGNDLLSRVNMLKNRL--------------QSLEAIEKDFLKN--KLNQDSGKST 375
+ EEE +L +V L+++L +SLE +K LK+ L+Q +
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 376 TALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYE-------TLERRYANERD 428
A + L QE++ L + L + + +L K + +++ ++ RYA ERD
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Query: 429 KAQFLSKELEHVKMELAK-----YKLAEKTETSHEQW-------------LFKRLQEEEA 470
+A+ ++E E + LA+ + E+ E ++Q + K + E E
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 471 KSGHLSREVDALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNR 518
L ++V+ ++ ++ E ATED L+ + LQ + Q E + R
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKR 1592
Query: 519 DLGREIENLTKELERYR 535
L +++ L ELE R
Sbjct: 1593 LLIKQVRELEAELEDER 1609
Score = 104 bits (259), Expect = 4e-22
Identities = 134/626 (21%), Positives = 275/626 (43%), Gaps = 71/626 (11%)
Query: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQ 64
E + +L Q Q++ + +LA +++Q E + L +E + + KF +
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 65 DQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYG 124
D ++ ++L + ++ ++ LS +I +LEE SL++ +EE ++ ++ + K
Sbjct: 1309 DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK---- 1364
Query: 125 NAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRI 184
+V L+ ++ D + K ++ + E + K+L KD + ++L ++
Sbjct: 1365 ------QVLALQSQLADTKKKVDDDLGTIESLEEAKKKL------LKDAEALSQRLEEKA 1412
Query: 185 MALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRL----E 240
+A +KLE N+ +QE L +L+ +R L ++ + + E ++I +R +
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Query: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
+ E +E TK +L + + E L+ E+ + + QL+ + + + + +
Sbjct: 1473 RAEAEAREKETKALSLA-------RALEEALEAKEE-FERQNKQLRADMEDLMSSKDDVG 1524
Query: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360
+ KSK +E+++ + + ++L+++L+A E+ L VNM Q+++A +
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA--KLRLEVNM-----QAMKAQFE 1577
Query: 361 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
L+ + Q+ K + Q EL E ++ L + K +E DL E + E
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637
Query: 421 RRYANERDKAQFLSKELEHVKMEL-----------AKYKLAEKTETSHEQWLFKRLQEEE 469
+ + + L +++ + EL A+ K +EK S E + +LQEE
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEIL-QLQEEL 1696
Query: 470 AKS----GHLSREVDALKEKI-----------HEYMATEDLICHLQGDHSVLQKKLNQQE 514
A S H +E D L ++I E E I L+ + Q +
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Query: 515 NRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE---PPD 571
+R R +++ L EL R + + S N R+ + Q +KE++ + + E
Sbjct: 1757 DRFRKTTLQVDTLNAELAAER---SAAQKSDNARQQLERQ--NKELKAKLQELEGAVKSK 1811
Query: 572 YKSLIPLERAVINGQLYEESENQDED 597
+K+ I A I GQL E+ E + ++
Sbjct: 1812 FKATISALEAKI-GQLEEQLEQEAKE 1836
Score = 99.0 bits (245), Expect = 2e-20
Identities = 117/571 (20%), Positives = 245/571 (42%), Gaps = 74/571 (12%)
Query: 70 MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIM 129
+ ++T ++ + + ++L + + ++E + + ++L + K +++ +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 130 AEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK 189
AE EE+R R + K +EL EE DL R+E E +++ + E +K+ I LE+
Sbjct: 904 AEAEEMRAR---LAAKKQEL---EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 190 LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVR------IKELEAIESRLEKTE 243
D ++Q K LEK K E E L + IKE + +E R+ +
Sbjct: 958 QLDEEEGARQ-----KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 244 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEET 303
L E+ K K L K +K + S L+ E+ K T + +E+
Sbjct: 1013 SQLAEEEEKAKNLA---------------KIRNKQEVMISDLE-ERLKKEEKTRQELEKA 1056
Query: 304 KRALKSK-TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN----MLKNRLQSLEAI 358
KR L + TD+++++ + + D+LK +L +EE+ L+R + N L+ + +
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 359 EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD----------------- 401
+ +L +D + ++ + ++LS+E+E LK +L+D
Sbjct: 1117 QAQIA--ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174
Query: 402 -----MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 456
KA+E++ E + + + +R+A ++ ++ + K L K K +T+
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234
Query: 457 HEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLI--------CHLQGDHSVLQK 508
K LQ+ +A+S H +++DA +++H ++ D + LQ + +
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 509 KLNQQENRNRDLGREIENLTKELERYRH-FSKSLRPSLN-GRRISDPQVFSKEVQTEAVD 566
L + E + ++ +L +L+ + + R LN RI + +Q + +
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 567 NEPPDYKSLIPLERAVINGQLYEESENQDED 597
E + + + + + QL + + D+D
Sbjct: 1355 EE--EARKNLEKQVLALQSQLADTKKKVDDD 1383
Score = 96.7 bits (239), Expect = 9e-20
Identities = 129/592 (21%), Positives = 243/592 (41%), Gaps = 72/592 (12%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRL------- 51
+D Q+++ + L +++K +L K + A AEA +E+E KA L
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 52 ---EKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 108
++E + Q + D + +M+ + +L++ AL +Q++E+ L + E
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT---QLEELE 1552
Query: 109 EELQDIKEKISKGEYGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERET 167
+ELQ ++ + E + A+ E +L+ R E K LIK Q R+L LE E
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK---QVRELEAELEDER 1609
Query: 168 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 227
Q +K+ + LE +A NK++ E L K + K +ELE +
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK---QLRKLQAQMKDYQRELEEARA 1666
Query: 228 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 287
E+ A EK +L+ ++ +L+ E SE+ ++ ++ + +L
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQ--------EELASSERARRHAEQER---DELAD 1715
Query: 288 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNM 347
E + L++E +R +EE++ EEE+ N L
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEEL----------------EEEQSNMELLNDRF 1759
Query: 348 LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE-RLKLKLK-DMKAI 405
K LQ + + Q S + L ++N ++K QE+E +K K K + A+
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISAL 1819
Query: 406 EDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 465
E + + E++ E + A + K+L+ + M++ + E H +++
Sbjct: 1820 EAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV-------EDERRHADQYKEQM 1872
Query: 466 QEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIE 525
++ A+ L R+++ +E+ A+ LQ++L+ N L RE+
Sbjct: 1873 EKANARMKQLKRQLEEAEEEATRANASR----------RKLQRELDDATEANEGLSREVS 1922
Query: 526 NLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIP 577
L L R S S S +GRR + S E+ + +++ D P
Sbjct: 1923 TLKNRLRRGGPISFS--SSRSGRRQLHLEGASLELSDDDTESKTSDVNETQP 1972
Score = 95.1 bits (235), Expect = 3e-19
Identities = 136/622 (21%), Positives = 272/622 (43%), Gaps = 79/622 (12%)
Query: 11 AQLTLQRQKIQELTTNAKETHTKLALA-------------EARVQEEEQKATRLEKE--- 54
A L Q Q QEL +ET KL L+ + + +EEE+ LEK+
Sbjct: 1311 ASLESQLQDTQELLQ--EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLA 1368
Query: 55 LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQI-------DELEETNRSLRKA 107
LQ+Q + D + + + + ++L + ALS+++ D+LE+T L++
Sbjct: 1369 LQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQE 1428
Query: 108 EEEL-------QDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE-ELIKMEEQCRDL 159
++L + + + K + ++AE + + R + + E E + E + L
Sbjct: 1429 LDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488
Query: 160 NKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKE----RMTT 215
+ LE ++F+ + ++L + L +D K+ E K LE++ R
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1548
Query: 216 KQLSQEL---ESLKVRIK-ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKL 271
++L EL E K+R++ ++A++++ E+ T E + K L + V E + E
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Query: 272 KK-------TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 324
+K ++ K++ L+ + +++I++ ++ D + ++ R
Sbjct: 1609 RKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASR 1668
Query: 325 DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI------EKDFLKNKL-NQDSGKSTTA 377
D++ + K E+K L + + L+ L S E E+D L +++ N SGKS A
Sbjct: 1669 DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKS--A 1726
Query: 378 LHQENNKIK-ELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQ----- 431
L E +++ ++Q E L+ + +M+ + D KT + +TL A ER AQ
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786
Query: 432 -----FLSKELEHVKMEL-----AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDA 481
+KEL+ EL +K+K + L ++L++E + ++ V
Sbjct: 1787 RQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846
Query: 482 LKEKIHE-YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 540
++K+ E +M ED H ++++ + R + L R++E +E R +
Sbjct: 1847 TEKKLKEIFMQVEDERRHA----DQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRK 1902
Query: 541 LRPSLNGRRISDPQVFSKEVQT 562
L+ L+ ++ + S+EV T
Sbjct: 1903 LQRELDDATEAN-EGLSREVST 1923
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 112 bits (281), Expect = 1e-24
Identities = 141/573 (24%), Positives = 261/573 (45%), Gaps = 78/573 (13%)
Query: 17 RQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNE 76
++K++EL T K+ + L +++++ +++ LEKELQ+ + + I K+ +
Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711
Query: 77 DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELR 136
N +L+ K+ L +++++ E N +LR+ L ++K + +EVE LR
Sbjct: 712 LLCNLELEGKITDLQKELNKEVEENEALREEVILLSELK-----------SLPSEVERLR 760
Query: 137 KRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNK 196
K + D K EEL + + L + + + + E+ K + + + ++
Sbjct: 761 KEIQD---KSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQ 817
Query: 197 SKQECYSLKCNLE-KERMT---TKQLSQELESLKVRIKELEAIESRLE--KTEFTLKEDL 250
Q +L + E K +M ++++QE+ +L KE + +S L KTE + K
Sbjct: 818 EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS---KEAQKFDSSLGALKTELSYKTQE 874
Query: 251 TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL---IEETKRAL 307
+ KT V ER E+LK ++L+ S LQ + + T +TEKL +EE K
Sbjct: 875 LQEKTRE---VQERLNEMEQLK---EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLT 928
Query: 308 KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK--DFLKN 365
+ K D+++ S+ ERD LK+ + + N + L+N L+SL+ ++ + LK+
Sbjct: 929 QEKDDLKQLQESLQIERDQLKSDI---HDTVNMNIDTQEQLRNALESLKQHQETINTLKS 985
Query: 366 KLNQDSGKSTTALHQENNKIK---ELSQEV----ERLKLKLKDMKAIEDDLMKTEDEYET 418
K++++ ++ LH E N + E Q++ ++ L+ K+ + + D+ ++E
Sbjct: 986 KISEEVSRN---LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADV--KDNEIIE 1040
Query: 419 LERRYANERDKAQFLSKELEHV--KMELAKYKLAEKTETSHEQWLFKRLQEEE------- 469
+R+ + + L + LE V + E K L E E + E RL +E
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI 1100
Query: 470 ---------AKSGHLSREVD-------ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 513
K G LSR D LKEK + + + ++Q + S +QKK+N+
Sbjct: 1101 VAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEI 1160
Query: 514 ENRNRDLGREIENLTKELERYRHFSKSLRPSLN 546
EN L E++N LE L LN
Sbjct: 1161 EN----LKNELKNKELTLEHMETERLELAQKLN 1189
Score = 111 bits (278), Expect = 3e-24
Identities = 147/674 (21%), Positives = 297/674 (44%), Gaps = 123/674 (18%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 62
+DE +R ++ T Q Q+L +++HTKL + EE++ +++ +TQ T
Sbjct: 1251 IDELRRSVSEKTAQIINTQDL----EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETM- 1305
Query: 63 HQDQDTIMAKLTNEDSQN-RQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 121
+ + + + T +DS +++ + L+ + E +E +SL K + L+ IKE +
Sbjct: 1306 -NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL--- 1361
Query: 122 EYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRL-ERETLQSKD---FKLEV 177
E + + + E ++ + + K E+ + M+E+ + K + E E + KD ++E+
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEI 1421
Query: 178 EKL--SKRIMA--------------LEKLEDAFN------------------KSKQECYS 203
E L SKR+ L++L++ ++++E
Sbjct: 1422 EMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKV 1481
Query: 204 LKCNLEKERMTTKQLSQELESLKVRI----KELEAIESRLEKTEFTLKEDLTKLKTLTVM 259
C L+++ T +L L + I K+LEAI +L+ ++E K + +
Sbjct: 1482 AHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQN---KIQEIYEKEEQFNIK 1538
Query: 260 FVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL---IEETKRALKSKTDVEEK 316
+ E + +LK+ ++ +A S LQ ++K+ +T +L EE + +K K +++
Sbjct: 1539 QISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRV 1598
Query: 317 MYSVTKERDDLKN-------KLKAEEEKGNDLL--SRVNMLKNRLQSLEAIEKDFLKNKL 367
++ ERD LK K+K +EK L + VN + ++ +E +++ F KL
Sbjct: 1599 QEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL 1658
Query: 368 NQDSGKS-----TTALHQENNKIKELSQE------------VERLKLKLKDMKAIEDDLM 410
N ++ ++ T LH+ +++ +++E VER +LK + I DL
Sbjct: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
Query: 411 KTE----------DEYETLERRYANERDKAQFLS---KELEHVK--MELAKYKLAEKTET 455
K E + ET+++ +K +S K+LEH ++ K+ E+
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778
Query: 456 SH-----EQWLFKRLQ----EEEAKSGHLSREVD----ALKEKIHEYMATEDLICHLQGD 502
+H +Q +L+ E+ K ++ ++++ L+EKI E A E + L+ D
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD 1838
Query: 503 HSVLQKKLNQQENRNRDL--------GREIENLT---KELERYRHFSKSLRPSLNGRRIS 551
+ QKK+++ E + + EIENL K E ++ N RR+
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE 1898
Query: 552 DPQVFSKEVQTEAV 565
+ ++ E++
Sbjct: 1899 ETLKLERDQLKESL 1912
Score = 95.9 bits (237), Expect = 1e-19
Identities = 125/593 (21%), Positives = 264/593 (44%), Gaps = 74/593 (12%)
Query: 4 DEQQRLTAQLTLQ----RQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE---KELQ 56
D+ QRL L + ++ I+E+ ET +L +A ++E+E+ L E +
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 57 TQTTKFHQDQDTIMAKLTNEDSQNRQLQQK-----LAALSRQIDELEETNRSLRKAEEEL 111
T+ + + + I KL N+ + + +++ ++ + +++EL++ + + L
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL 1564
Query: 112 QDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSK 171
Q I+ K+ + E++ + K +M+ E L +Q ++ K + + +S+
Sbjct: 1565 QSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 172 DFKLEVEKLS------KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE-LES 224
+ + + K++ +++ +E L++ F K N+E E + Q+ E LE
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE----NIETENIRLTQILHENLEE 1680
Query: 225 LKVRIKE---LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 281
++ KE L ++E L+ LKE+L + T + +E K + LK+ ++ +
Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKL 1740
Query: 282 SSQLQVEQNKVTTVTEKLIEETKRALKSKT-DVEEKM---YSVTKERDDLKNKLKAEEEK 337
+ + N+++ + +K +E + ALK++ ++E++ + KE+ + +KL+ +
Sbjct: 1741 RGIVSEKTNEISNM-QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSE 1799
Query: 338 GNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKL 397
D LS NM K+ S +++ + K N+ L ++ N+ ++ E+E+LK
Sbjct: 1800 KTDKLS--NMQKDLENSNAKLQEKIQELKANEHQ---LITLKKDVNETQKKVSEMEQLKK 1854
Query: 398 KLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSH 457
++KD L K E E L ++ ++ + + KE ++++ E+T
Sbjct: 1855 QIKDQSLT---LSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR-------VEETLKLE 1904
Query: 458 EQWLFKRLQEEEAKSGHLSRE--------------VDALKEKIHE-YMATEDLICHLQGD 502
L + LQE +A+ + +E VD L+EKI E + D+ L
Sbjct: 1905 RDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKS 1964
Query: 503 HSVLQKKLNQQENRNRDLGR-------------EIENLTKELERYRHFSKSLR 542
LQKK+ + + + L R E+E L K+ E +S+R
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017
Score = 94.7 bits (234), Expect = 3e-19
Identities = 129/618 (20%), Positives = 278/618 (44%), Gaps = 81/618 (13%)
Query: 7 QRLTA-----QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTK 61
Q LTA ++ Q++KI L E L E+ + E+EQ T L++ ++ T +
Sbjct: 1027 QTLTADVKDNEIIEQQRKIFSLIQEKNELQQML---ESVIAEKEQLKTDLKENIE-MTIE 1082
Query: 62 FHQDQDTIMAKLTNEDS----QNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 117
++ + +L + + +K LSR D L E L++ ++LQ+ +++
Sbjct: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142
Query: 118 ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDL-NKRLERETLQSKDFKLE 176
+ + E+ E++K++ ++E EL E + +RLE +++++ E
Sbjct: 1143 L-------LNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYE-E 1194
Query: 177 VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAI- 235
V+ ++K L++L+ +F + L+ + + T Q +EL+ + +KE +
Sbjct: 1195 VKSITKERKVLKELQKSFETERDH---LRGYIREIEATGLQTKEELKIAHIHLKEHQETI 1251
Query: 236 -ESRLEKTEFT--------LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 286
E R +E T L++ TKL+ + +E++ + + +E + +L
Sbjct: 1252 DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELL 1311
Query: 287 VEQN--KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSR 344
EQ+ K +T ++ E R + + +E++ S+TKERD+LK +A E K + L
Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371
Query: 345 VNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL----K 400
+ ++Q ++ ++ L K + TT + E + K + R+++++ K
Sbjct: 1372 IRETLAKIQESQSKQEQSLNMK---EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK 1428
Query: 401 DMKAIEDDL---MKTEDEYETLERRYANERDK-----AQFLSKELE-HVKMELAKYKLAE 451
++ D++ K +D+ + L+ +E D+ + ++K LE ++++A L E
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488
Query: 452 KTETSHEQWLFKRLQEEEAKSGHLSREVDA----LKEKIHEYMATEDLIC---------- 497
+ ET +E L L E+E + + ++++A L+ KI E E+
Sbjct: 1489 QEETINE--LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546
Query: 498 ---------HLQGDHSVLQ---KKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 545
H + S LQ K+ + NR ++ EI+ + KE E + ++L+
Sbjct: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606
Query: 546 NGRRISDPQVFSKEVQTE 563
+ + + ++ +K +++
Sbjct: 1607 DQLKENTKEIVAKMKESQ 1624
Score = 91.7 bits (226), Expect = 3e-18
Identities = 124/570 (21%), Positives = 241/570 (42%), Gaps = 66/570 (11%)
Query: 9 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 68
L +L+ + Q++QE T +E ++ + +++ + +E+E T K Q +
Sbjct: 864 LKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE 923
Query: 69 IMAKLTNEDSQNRQLQQKLAALSRQI-DELEETNRSLRKAEEELQDIKEKISKGEYGNAG 127
+ LT E +QLQ+ L Q+ ++ +T +E+L++ E + + +
Sbjct: 924 VKT-LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINT 982
Query: 128 IMAEVEELRKRVLDME---GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRI 184
+ +++ E R L ME G+ ++ + + D + LE + Q+ ++ ++ ++
Sbjct: 983 LKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQ 1042
Query: 185 MALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEF 244
+ L N+ +Q S+ EKE++ T L + +E +EL + L+K +
Sbjct: 1043 RKIFSLIQEKNELQQMLESVIA--EKEQLKT-DLKENIEMTIENQEELRLLGDELKKQQ- 1098
Query: 245 TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL----- 299
E + + K + E ++L + E+KL+ S QLQ +Q ++ V E++
Sbjct: 1099 ---EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK 1155
Query: 300 ----IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 355
IE K LK+K E M + ER +L KL E+ + +LK +S
Sbjct: 1156 KINEIENLKNELKNKELTLEHMET---ERLELAQKLNENYEEVKSITKERKVLKELQKSF 1212
Query: 356 EAIEKDFLKNKLN--QDSGKSTTA--------LHQENNKIKELSQEVERLKLKLKDMKAI 405
E E+D L+ + + +G T L + I EL + V ++ + + +
Sbjct: 1213 ET-ERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDL 1271
Query: 406 EDDLMKTEDEYETLERRY-----ANERDKAQFLSKELEHV-------------KMELAKY 447
E K ++E L E + Q ELE + ++E+ +
Sbjct: 1272 EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERL 1331
Query: 448 KLAEKTETSHEQWLFKRLQEEEAKSGHLSREV--DALKEKIHEYMATEDLICHLQGDHSV 505
+L EK + S E+ + + K+ + EV D LKE I E +A +Q S
Sbjct: 1332 RLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA------KIQESQSK 1385
Query: 506 LQKKLNQQENRNRDLGREIENLTKELERYR 535
++ LN +E N E + E+E+++
Sbjct: 1386 QEQSLNMKEKDN-----ETTKIVSEMEQFK 1410
Score = 88.6 bits (218), Expect = 2e-17
Identities = 124/614 (20%), Positives = 275/614 (44%), Gaps = 52/614 (8%)
Query: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQ 64
E +RL ++ + +++ +T+ + +++ E+RVQ ++ + + +L T + +
Sbjct: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814
Query: 65 -DQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
DQ+ K + D + ++ + L R E+ ++ +K + L +K ++S Y
Sbjct: 815 TDQEFQNFKTLHMDFE-QKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS---Y 870
Query: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKR 183
+ + E+++R+ +ME E+L + + + + T + + EV+ L++
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE 930
Query: 184 IMALEKLEDAFNKSKQECYS-LKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK- 241
L++L+++ + + S + + T +QL LESLK + + ++S++ +
Sbjct: 931 KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEE 990
Query: 242 --TEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ---LQVEQNKVTTVT 296
++E+ + K DE + + K +D L+A ++Q V+ N++
Sbjct: 991 VSRNLHMEENTGETK-------DEFQQKMVGIDKKQD-LEAKNTQTLTADVKDNEIIEQQ 1042
Query: 297 EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 356
K+ ++ K ++++ + SV E++ LK LK E + + +L + L+ +
Sbjct: 1043 RKIFS----LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQ 1098
Query: 357 AIEKDFLKNKLNQDSGKSTTA--LHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTED 414
I + + ++ S T L + K+KE SQ+++ + +L +++ ++ K +
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN 1158
Query: 415 EYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE----TSHEQWLFKRLQEE-E 469
E E L+ NE + + +E ++ELA+ KL E E + E+ + K LQ+ E
Sbjct: 1159 EIENLK----NELKNKELTLEHMETERLELAQ-KLNENYEEVKSITKERKVLKELQKSFE 1213
Query: 470 AKSGHLS---REVDALKEKIHEYMATEDLICHLQGDHSVLQK------KLNQQENRNRDL 520
+ HL RE++A + E + + HL+ + + + Q +DL
Sbjct: 1214 TERDHLRGYIREIEATGLQTKEELKIAHI--HLKEHQETIDELRRSVSEKTAQIINTQDL 1271
Query: 521 GREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSL--IPL 578
+ L +E+ H + L P N + +S+ Q E++ + D +L I +
Sbjct: 1272 EKSHTKLQEEIP-VLHEEQELLP--NVKEVSETQETMNELELLTEQSTTKDSTTLARIEM 1328
Query: 579 ERAVINGQLYEESE 592
ER +N + E E
Sbjct: 1329 ERLRLNEKFQESQE 1342
Score = 76.3 bits (186), Expect = 1e-13
Identities = 121/587 (20%), Positives = 267/587 (45%), Gaps = 92/587 (15%)
Query: 15 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 74
+Q +KI+ LT T + L L + + +++ T ++ + DQ I +T
Sbjct: 389 VQNEKIENLT-RMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNIT 447
Query: 75 NEDSQN-----RQLQQKLAA----LSRQIDELEET--NRSLRKAEEELQDIKEKISKGEY 123
+ + R++ + + + S +D L E N + + +E + + + +Y
Sbjct: 448 TKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADY 507
Query: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKR 183
N ++ + E+LR +ME K +E ++E + LER+T + ++ +L + ++S
Sbjct: 508 DN--LVLDYEQLRTEKEEMELKLKEKNDLDEF-----EALERKTKKDQEMQL-IHEISN- 558
Query: 184 IMALEKLEDAFNKSKQECYSLKCNLEKERMTT-KQL-----SQELESLKVRIK-ELEAIE 236
+ L K + +N+ + S K L +E+ K+L SQ+LE++K+ + LE+IE
Sbjct: 559 LKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIE 618
Query: 237 S--RLEKTEFT---------------------LKEDLTKLKTLTVMFVDERKTMSEKLKK 273
++++T F LKE + +L T ++ + +L+
Sbjct: 619 DPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEA 678
Query: 274 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 333
+ +LQ N++T +T + + + L ++E K+ DL+ +L
Sbjct: 679 KKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKI-------TDLQKELNK 731
Query: 334 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI-KELSQEV 392
E E+ N+ L +L + L+SL + E + L+ ++ QD + + E +K+ E+ +
Sbjct: 732 EVEE-NEALREEVILLSELKSLPS-EVERLRKEI-QDKSEELHIITSEKDKLFSEVVHKE 788
Query: 393 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER--------------DKAQFLSKELE 438
R++ L+++ +DDL T+ Y++ ++ + N + ++ + +++E+
Sbjct: 789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIV 848
Query: 439 HVKMELAKYKL---AEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 495
++ E K+ A KTE S++ + LQE+ + E++ LKE++ +T
Sbjct: 849 NLSKEAQKFDSSLGALKTELSYKT---QELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
Query: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 542
+ + + +++ +KL Q E++ LT+E + + +SL+
Sbjct: 906 V---EREKTLITEKLQQTL-------EEVKTLTQEKDDLKQLQESLQ 942
Score = 73.2 bits (178), Expect = 1e-12
Identities = 119/564 (21%), Positives = 251/564 (44%), Gaps = 105/564 (18%)
Query: 13 LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF---HQDQDTI 69
L Q KIQE +L +A ++E+++ +L + +T K +D +
Sbjct: 1765 LKAQDLKIQE----------ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 70 MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIM 129
AKL + + + + +L L + ++E ++ + + +++++D +SK E N +
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL- 1873
Query: 130 AEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK 189
++L + + +M+ +E RD +R+E ETL KLE ++
Sbjct: 1874 --AQKLHENLEEMKSVMKE--------RDNLRRVE-ETL-----KLE----------RDQ 1907
Query: 190 LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE----LEAIESRLEKTEFT 245
L+++ ++K ++ L+ RM +K+ + ++ L+ +I E + I+ L+K++
Sbjct: 1908 LKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967
Query: 246 LKEDLTKL--KTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEET 303
L++ + +L K L ++ V E MS K ++++ Q + + + +V + T
Sbjct: 1968 LQKKIQELQKKELQLLRVKEDVNMSH---KKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024
Query: 304 KRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFL 363
K+ +S E++ V KERD+L+ ++ + + + ++ + + R + ++ +
Sbjct: 2025 KKLHESL----EEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE-- 2078
Query: 364 KNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRY 423
K L+ T +L ++ ++IKEL + + +D YE L R
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEM-----------------DDHYECLNRLS 2121
Query: 424 ANERDKAQFLSKELEHVKMELA----KYKLAEKTETSHEQ--WLFKRLQEEEAKSGHLSR 477
+ + +F + VK L+ + K EK T++++ F R+ + K ++
Sbjct: 2122 LDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMK---KLKYVLS 2178
Query: 478 EVDALKEKIHEYMATEDL---------------ICHLQGDHSVLQKKLNQQE-NRNRDLG 521
V +KE+ HE + ++ I HLQ D V ++L + N+N DL
Sbjct: 2179 YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL- 2237
Query: 522 REIENLTKELERYRHFSKSLRPSL 545
IE + K+ FS+S PS+
Sbjct: 2238 -HIEEILKD------FSESEFPSI 2254
Score = 63.5 bits (153), Expect = 8e-10
Identities = 119/620 (19%), Positives = 256/620 (41%), Gaps = 110/620 (17%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKL--ALAEARVQEEEQKATRLEKELQTQTT 60
++E ++L Q Q +Q + + + KL +L E R+ +E+ R KE +
Sbjct: 1996 INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE----SL 2051
Query: 61 KFHQDQD-TIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 119
K +DQ + ++ D QN Q++ + LS D + SLR+ ++++ ++ S
Sbjct: 2052 KMERDQFIATLREMIARDRQNHQVKPEKRLLS---DGQQHLTESLREKCSRIKELLKRYS 2108
Query: 120 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK----- 174
+ + E L + LD+E +E+ +E + L LQ+K +
Sbjct: 2109 EMD-------DHYECLNRLSLDLE---KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTA 2158
Query: 175 -----LEVEKLSKRIMAL--------EKLEDAFNKSKQECYSLKCNLEKER---MTTKQL 218
+E ++ K++ + E+ ++ NK + + +EK++ + + L
Sbjct: 2159 NQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFID---EVEKQKELLIKIQHL 2215
Query: 219 SQELESLKVRIKELEAIESRLEKTEFTLKE----DLTKLKTLTVMFVDERKTMSEKLKK- 273
Q+ + +++L+ ++ E LK+ + +KT + RK M++ L++
Sbjct: 2216 QQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEW 2275
Query: 274 --TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKL 331
T ++ + +Q E +++ V + T+ EE+ +++KE + L
Sbjct: 2276 LNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE---WEQDL 2332
Query: 332 KAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST---------------- 375
K+ +EK L LK L S + NK + ++T
Sbjct: 2333 KSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHE 2392
Query: 376 ---TALHQENNKIKELSQEVE-------RLKLKLKDMKAIEDDLMKTEDEYETLERRYA- 424
+A+H+E +KI ++ +E+E +L+ K+ + L KT++ + L+ + A
Sbjct: 2393 AKESAMHKE-SKIIKMQKELEVTNDIIAKLQAKVHESNKC---LEKTKETIQVLQDKVAL 2448
Query: 425 -NERDKAQFLSKELEHVKMELAKYKLAEKTE--------TSHEQWLFKRLQEEEAKSGHL 475
+ K + +++ VK++L K K A++ E T Q RL E +
Sbjct: 2449 GAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQ 2508
Query: 476 SREVDALKEKIHEYMATEDLICH-------------LQGDHSVLQKKLNQQENRNRDLGR 522
+++ + E + + L C L+ +H L+K++++ + +N L
Sbjct: 2509 AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQL-- 2566
Query: 523 EIENLTKELERYRHFSKSLR 542
I+ + L +H S ++
Sbjct: 2567 -IKQKNELLSNNQHLSNEVK 2585
Score = 54.3 bits (129), Expect = 5e-07
Identities = 133/631 (21%), Positives = 244/631 (38%), Gaps = 89/631 (14%)
Query: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
++ D QQ LT L + +I+EL E R+ + +K +KEL +
Sbjct: 2081 LLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLN-RLSLDLEKEIEFQKELSMR-- 2137
Query: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK--- 117
+ A L+ Q + +++ A R E + L+ + IKE+
Sbjct: 2138 --------VKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHE 2189
Query: 118 -ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDL----NKRLERETLQSKD 172
I+K E + EVE+ ++ ++ ++ ++ + RDL N L E + KD
Sbjct: 2190 SINKFEMD---FIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEIL-KD 2245
Query: 173 F--------KLEVEK-LSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE 223
F K E ++ LS R + LE+ N ++ + LK ++KE Q++
Sbjct: 2246 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLN-TRFDIEKLKNGIQKENDRICQVNNFFN 2304
Query: 224 SLKVRI-KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKK-------TE 275
+ + I E E R ++DL LK +T+ L T+
Sbjct: 2305 NRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQ 2364
Query: 276 DKLQ--AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 333
D S Q+ K+ + L E + A+ ++ + KM + +D+ KL+A
Sbjct: 2365 DNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII-KMQKELEVTNDIIAKLQA 2423
Query: 334 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 393
+ + N L + LQ A+ K ++ K ++ KE +E+
Sbjct: 2424 KVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEIS 2483
Query: 394 RLKLKLKDMKAI----EDDLMKTEDEYETLERRYANERDKAQFLSKEL------------ 437
K ++ K + ++L +++ +T +E Q +K L
Sbjct: 2484 ATKATVEYQKEVIRLLRENLRRSQQAQDT---SVISEHTDPQPSNKPLTCGGGSGIVQNT 2540
Query: 438 -------EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYM 490
EH+++E KL ++ E L K+ E + + HLS EV KE+ +
Sbjct: 2541 KALILKSEHIRLEKEISKLKQQNEQ-----LIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595
Query: 491 ATEDLICH-------LQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRP 543
A + + C + G S +K++ + + R+L + + + + SKSL P
Sbjct: 2596 AHKQVTCENSPKSPKVTGTAS-KKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSL-P 2653
Query: 544 SLNGRRISDPQVFS--KEVQ---TEAVDNEP 569
S + R D EVQ E+VD++P
Sbjct: 2654 SPHPVRYFDNSSLGLCPEVQNAGAESVDSQP 2684
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 112 bits (280), Expect = 2e-24
Identities = 122/547 (22%), Positives = 255/547 (46%), Gaps = 73/547 (13%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ T +F + +D +L +++ ++L++K+ L ++ ++L+ ++
Sbjct: 847 KSAETEKEMATMKEEFQKIKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQA 899
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 161
E L D +E+ + + A+++E+ +R D E + EL K+E++C +L K
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 959
Query: 162 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 207
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 208 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD-E 263
+K TK +L Q+++ L+ +++ + + LE+ + L+ DL KL ++M ++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENE 1078
Query: 264 RKTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 313
++ + EKLKK E ++ QA QLQ + ++ E+L EE + S+
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138
Query: 314 EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK 373
E++ +++E +++ +L EE G +++ M K R + + +D L+ Q
Sbjct: 1139 EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRD-LEEATLQHEAT 1194
Query: 374 STTALHQENNKIKELSQEV---ERLKLKLK----DMKAIEDDLMKTEDEYETLERRYANE 426
+ T + + + EL +++ +R+K KL+ +MK DDL ET+ + N
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL---ASNVETVSKAKGNL 1251
Query: 427 RDKAQFLSKELEHVK------MELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSR-- 477
+ L +L +K L A++ E F R L E+EA LSR
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 478 -----EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLT 528
+++ LK ++ E + ++ + H + D +L+++ +++ +L R +
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 529 KELERYR 535
E+ ++R
Sbjct: 1372 TEVAQWR 1378
Score = 100 bits (248), Expect = 8e-21
Identities = 111/561 (19%), Positives = 236/561 (42%), Gaps = 74/561 (13%)
Query: 18 QKIQELTTNAKETHTKLALAEARVQEEEQ---KATRLEKELQTQTTKFHQDQDTIMAKLT 74
++ +L + K+ R ++EE+ + T +++L+ + ++ +D D + L
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 75 NEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI---SKGEYGNAGIMAE 131
+ + + K+ L+ ++ L+ET L K ++ LQ+ ++ + E + +
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 132 VE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKL 190
+ +L ++V D+EG E+ K+ ++LE D KL E + ++L
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE------GDLKLAQESIMDIENEKQQL 1082
Query: 191 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------AIESRLEKTE 243
++ K + E +L+ +E E+ QL ++++ L+ RI+ELE A ++ EK
Sbjct: 1083 DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 244 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ--VEQNKVTTVT----- 296
L +L ++ E KK E + Q L+ Q++ T T
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202
Query: 297 ----EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 352
+L E+ + K +E++ + E DDL + ++ + +L L+++L
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 353 QSLEAIEKD---------FLKNKLNQDSGKSTTALHQENNKIKELS-------QEVERLK 396
L++ E++ + +L +SG+ + L ++ + +LS Q++E LK
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 397 LKL----KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 452
+L K A+ L + + + L +Y E++ L + L E+A+++
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR---- 1378
Query: 453 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 512
T +E +R +E E L++ + A +E + + K
Sbjct: 1379 --TKYETDAIQRTEELEEAKKKLAQRLQAAEEHV-----------------EAVNAKCAS 1419
Query: 513 QENRNRDLGREIENLTKELER 533
E + L E+E+L ++ER
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVER 1440
Score = 95.5 bits (236), Expect = 2e-19
Identities = 136/680 (20%), Positives = 288/680 (42%), Gaps = 128/680 (18%)
Query: 4 DEQQRLTAQLTLQRQKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKEL 55
+EQQRL LT QR ++Q E +++ K AL +A Q+ E+ +LE+E+
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI 1329
Query: 56 QTQTTKFH------QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI--------------- 94
+ + H D D + + E +LQ+ L+ + ++
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389
Query: 95 DELEETNRSLRK----AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI 150
+ELEE + L + AEE ++ + K + E + EVE+L +LD+E +
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---MLDVERTNAACA 1446
Query: 151 KMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC 206
++++ R+ +K L + ++ E+E K +L K+++A+ +S + +LK
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKR 1506
Query: 207 ---NLEKERMT-TKQLSQ------ELESLKVRIKE--------LEAIESRLE-------- 240
NL++E T+Q+++ ELE +K ++++ LE E+ LE
Sbjct: 1507 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566
Query: 241 --------KTEFTLK-----EDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQA 280
K+E K E++ +LK + V+ + T+ +++ D K++
Sbjct: 1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626
Query: 281 ASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGND 340
++++++ N + + + + D + + + ++DLK +L E + N
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL 1686
Query: 341 LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLK 396
L + + L+ L+ E K + L D+ + LH +N + K+L ++ +++
Sbjct: 1687 LQAEIEELRATLEQTERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 397 LKLKDM------------KAIED------DLMKTEDEYETLERRYANER----------D 428
+++D+ KAI D +L K +D LER N D
Sbjct: 1745 GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD 1804
Query: 429 KAQFLS-----KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALK 483
+A+ L+ K+++ ++ + + + ++E K L++ E + L+ + + +
Sbjct: 1805 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1864
Query: 484 EKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRP 543
+ I + +DL+ LQ +++ + E ++ + L ELE +
Sbjct: 1865 KNI---LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAES 1921
Query: 544 SLNGRRISDPQVFSKEVQTE 563
+N R+ +V +K + E
Sbjct: 1922 QVNKLRVKSREVHTKVISEE 1941
Score = 93.6 bits (231), Expect = 7e-19
Identities = 125/567 (22%), Positives = 240/567 (42%), Gaps = 70/567 (12%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
D+ L ++ Q++ I +LT T+ ++ E+E ++L + Q F
Sbjct: 1260 DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA----FT 1315
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS---- 119
Q + + +L E L L + D L E ++++ ELQ K +
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 120 --KGEYGNAGIM--AEVEELRKRVLD-MEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 174
+ +Y I E+EE +K++ ++ +E + + +C L K +R + +D
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435
Query: 175 LEVEKLSKRIMALEKLEDAFNKS----KQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
L+VE+ + AL+K + F+K KQ+C LE + + L EL +K +
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495
Query: 231 E-LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDK--------LQAA 281
E L+ +E+ L++ L+++++ L T + +R EK+KK ++ L+ A
Sbjct: 1496 ESLDQLET-LKRENKNLQQEISDL-TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEA 1553
Query: 282 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLK-NKLKAEEEKGND 340
+ L+ E+ K+ + +L + K++V+ K+ +E D LK N ++ E +
Sbjct: 1554 EASLEHEEGKILRIQLELNQ-------VKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 341 LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLK 400
L + + + ++ LK K+ D + L+ N E + + LK
Sbjct: 1607 LDAEIRSRNDAIR---------LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 401 DMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQW 460
D + DD ++++ E L+ + A +A L E+E ++ L E+TE S
Sbjct: 1658 DTQIHLDDALRSQ---EDLKEQLAMVERRANLLQAEIEELRATL------EQTERS---- 1704
Query: 461 LFKRLQEEEAKSGHLSREVDALKEK----IHEYMATEDLICHLQGD-HSVLQKKLNQQEN 515
+++ E+E S V L + I+ E I +QG+ +LQ+ N +E
Sbjct: 1705 --RKIAEQELLDA--SERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEK 1760
Query: 516 RNR---DLGREIENLTKELERYRHFSK 539
+ D E L KE + H +
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLER 1787
Score = 92.8 bits (229), Expect = 1e-18
Identities = 119/565 (21%), Positives = 252/565 (44%), Gaps = 72/565 (12%)
Query: 9 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 68
L L +++ +L ++ L LA+ + + E + +L+++L+ + +
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI----SN 1095
Query: 69 IMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGI 128
+ +K+ +E + QLQ+K+ L +I+EL EEE++ + +K E + +
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEEL----------EEEIEAERASRAKAEKQRSDL 1145
Query: 129 MAEVEELRKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQSKDFKLEVEKLSKRI 184
E+EE+ +R+ + G I+M E + + + + LE TLQ + + K K
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK--KHA 1203
Query: 185 MALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEF 244
++ +L + + ++ +K LEKE+ ++ E++ L ++ + + LEK
Sbjct: 1204 DSVAELGEQIDNLQR----VKQKLEKEK---SEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 245 TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETK 304
TL++ L++L K+ E+ ++ + L A +LQ E + + ++ K
Sbjct: 1257 TLEDQLSEL-----------KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE-----K 1300
Query: 305 RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EAIEKDF 362
AL S+ ++ + T++ ++LK +L+ E + N L + ++ L + E+
Sbjct: 1301 EALVSQLSRGKQAF--TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 363 LKNKLNQDSGKSTTALHQENNKIK----ELSQEVERLKLKLKDMKAIEDDLMKTEDEYET 418
K +L + K+ T + Q K + + ++E+E K KL L E+ E
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR------LQAAEEHVEA 1412
Query: 419 LERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSRE 478
+ + A+ Q L E+E + +++ + A ++ K L E + K E
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1472
Query: 479 VDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFS 538
++A +K + TE + S+ Q + ++EN+N L +EI +LT+++
Sbjct: 1473 LEA-SQKEARSLGTELFKIKNAYEESLDQLETLKRENKN--LQQEISDLTEQIAE----- 1524
Query: 539 KSLRPSLNGRRISDPQVFSKEVQTE 563
G+RI + + K+V+ E
Sbjct: 1525 -------GGKRIHELEKIKKQVEQE 1542
Score = 64.7 bits (156), Expect = 4e-10
Identities = 96/500 (19%), Positives = 203/500 (40%), Gaps = 79/500 (15%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 62
+D+ + L + +Q+I +LT E ++ E ++ EQ+ L+ L+
Sbjct: 1498 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL 1557
Query: 63 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE 122
++ I+ + ++ +K+A +ID+L+ + + ++ + D
Sbjct: 1558 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD--------- 1608
Query: 123 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQS--------KDFK 174
AE+ + + + +L +ME Q N R+ E L++ KD +
Sbjct: 1609 -------AEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN-RMAAEALRNYRNTQGILKDTQ 1660
Query: 175 LEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
+ ++ + L++ +E N + E L+ LE+ + K QEL R++
Sbjct: 1661 IHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1720
Query: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 290
L + L T+ L+ D+++++ + E + EK KK + +L+ EQ+
Sbjct: 1721 LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780
Query: 291 KVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
+ +K +E+T + L+ + D E++ LK +++ L +RV L
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQL------------ALKGGKKQIQKLEARVREL 1828
Query: 349 KNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDD 408
+ ++S + K N ++ K L + ++KEL+ + E + + ++ + D
Sbjct: 1829 EGEVES---------EQKRNAEAVK---GLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 409 LMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEE 468
L Y +R A E + E LAK++ + HE L+E
Sbjct: 1877 LQAKVKSY----KRQAEEAE---------EQSNTNLAKFR-----KLQHE------LEEA 1912
Query: 469 EAKSGHLSREVDALKEKIHE 488
E ++ +V+ L+ K E
Sbjct: 1913 EERADIAESQVNKLRVKSRE 1932
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 112 bits (280), Expect = 2e-24
Identities = 122/547 (22%), Positives = 255/547 (46%), Gaps = 73/547 (13%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ T +F + +D +L +++ ++L++K+ L ++ ++L+ ++
Sbjct: 847 KSAETEKEMATMKEEFQKIKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQA 899
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 161
E L D +E+ + + A+++E+ +R D E + EL K+E++C +L K
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 959
Query: 162 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 207
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 208 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD-E 263
+K TK +L Q+++ L+ +++ + + LE+ + L+ DL KL ++M ++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENE 1078
Query: 264 RKTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 313
++ + EKLKK E ++ QA QLQ + ++ E+L EE + S+
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138
Query: 314 EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK 373
E++ +++E +++ +L EE G +++ M K R + + +D L+ Q
Sbjct: 1139 EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRD-LEEATLQHEAT 1194
Query: 374 STTALHQENNKIKELSQEV---ERLKLKLK----DMKAIEDDLMKTEDEYETLERRYANE 426
+ T + + + EL +++ +R+K KL+ +MK DDL ET+ + N
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL---ASNVETVSKAKGNL 1251
Query: 427 RDKAQFLSKELEHVK------MELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSR-- 477
+ L +L +K L A++ E F R L E+EA LSR
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 478 -----EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLT 528
+++ LK ++ E + ++ + H + D +L+++ +++ +L R +
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 529 KELERYR 535
E+ ++R
Sbjct: 1372 TEVAQWR 1378
Score = 100 bits (248), Expect = 8e-21
Identities = 111/561 (19%), Positives = 236/561 (42%), Gaps = 74/561 (13%)
Query: 18 QKIQELTTNAKETHTKLALAEARVQEEEQ---KATRLEKELQTQTTKFHQDQDTIMAKLT 74
++ +L + K+ R ++EE+ + T +++L+ + ++ +D D + L
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 75 NEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI---SKGEYGNAGIMAE 131
+ + + K+ L+ ++ L+ET L K ++ LQ+ ++ + E + +
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 132 VE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKL 190
+ +L ++V D+EG E+ K+ ++LE D KL E + ++L
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE------GDLKLAQESIMDIENEKQQL 1082
Query: 191 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------AIESRLEKTE 243
++ K + E +L+ +E E+ QL ++++ L+ RI+ELE A ++ EK
Sbjct: 1083 DEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQR 1142
Query: 244 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ--VEQNKVTTVT----- 296
L +L ++ E KK E + Q L+ Q++ T T
Sbjct: 1143 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202
Query: 297 ----EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 352
+L E+ + K +E++ + E DDL + ++ + +L L+++L
Sbjct: 1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQL 1262
Query: 353 QSLEAIEKD---------FLKNKLNQDSGKSTTALHQENNKIKELS-------QEVERLK 396
L++ E++ + +L +SG+ + L ++ + +LS Q++E LK
Sbjct: 1263 SELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 397 LKL----KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 452
+L K A+ L + + + L +Y E++ L + L E+A+++
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR---- 1378
Query: 453 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 512
T +E +R +E E L++ + A +E + + K
Sbjct: 1379 --TKYETDAIQRTEELEEAKKKLAQRLQAAEEHV-----------------EAVNAKCAS 1419
Query: 513 QENRNRDLGREIENLTKELER 533
E + L E+E+L ++ER
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVER 1440
Score = 95.5 bits (236), Expect = 2e-19
Identities = 136/680 (20%), Positives = 288/680 (42%), Gaps = 128/680 (18%)
Query: 4 DEQQRLTAQLTLQRQKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKEL 55
+EQQRL LT QR ++Q E +++ K AL +A Q+ E+ +LE+E+
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEI 1329
Query: 56 QTQTTKFH------QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI--------------- 94
+ + H D D + + E +LQ+ L+ + ++
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389
Query: 95 DELEETNRSLRK----AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI 150
+ELEE + L + AEE ++ + K + E + EVE+L +LD+E +
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---MLDVERTNAACA 1446
Query: 151 KMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC 206
++++ R+ +K L + ++ E+E K +L K+++A+ +S + +LK
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKR 1506
Query: 207 ---NLEKERMT-TKQLSQ------ELESLKVRIKE--------LEAIESRLE-------- 240
NL++E T+Q+++ ELE +K ++++ LE E+ LE
Sbjct: 1507 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566
Query: 241 --------KTEFTLK-----EDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQA 280
K+E K E++ +LK + V+ + T+ +++ D K++
Sbjct: 1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626
Query: 281 ASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGND 340
++++++ N + + + + D + + + ++DLK +L E + N
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL 1686
Query: 341 LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLK 396
L + + L+ L+ E K + L D+ + LH +N + K+L ++ +++
Sbjct: 1687 LQAEIEELRATLEQTERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Query: 397 LKLKDM------------KAIED------DLMKTEDEYETLERRYANER----------D 428
+++D+ KAI D +L K +D LER N D
Sbjct: 1745 GEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD 1804
Query: 429 KAQFLS-----KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALK 483
+A+ L+ K+++ ++ + + + ++E K L++ E + L+ + + +
Sbjct: 1805 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDR 1864
Query: 484 EKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRP 543
+ I + +DL+ LQ +++ + E ++ + L ELE +
Sbjct: 1865 KNI---LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAES 1921
Query: 544 SLNGRRISDPQVFSKEVQTE 563
+N R+ +V +K + E
Sbjct: 1922 QVNKLRVKSREVHTKVISEE 1941
Score = 93.6 bits (231), Expect = 7e-19
Identities = 125/567 (22%), Positives = 240/567 (42%), Gaps = 70/567 (12%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
D+ L ++ Q++ I +LT T+ ++ E+E ++L + Q F
Sbjct: 1260 DQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQA----FT 1315
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS---- 119
Q + + +L E L L + D L E ++++ ELQ K +
Sbjct: 1316 QQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA 1375
Query: 120 --KGEYGNAGIM--AEVEELRKRVLD-MEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 174
+ +Y I E+EE +K++ ++ +E + + +C L K +R + +D
Sbjct: 1376 QWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1435
Query: 175 LEVEKLSKRIMALEKLEDAFNKS----KQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
L+VE+ + AL+K + F+K KQ+C LE + + L EL +K +
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495
Query: 231 E-LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDK--------LQAA 281
E L+ +E+ L++ L+++++ L T + +R EK+KK ++ L+ A
Sbjct: 1496 ESLDQLET-LKRENKNLQQEISDL-TEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEA 1553
Query: 282 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLK-NKLKAEEEKGND 340
+ L+ E+ K+ + +L + K++V+ K+ +E D LK N ++ E +
Sbjct: 1554 EASLEHEEGKILRIQLELNQ-------VKSEVDRKIAEKDEEIDQLKRNHIRIVESMQST 1606
Query: 341 LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLK 400
L + + + ++ LK K+ D + L+ N E + + LK
Sbjct: 1607 LDAEIRSRNDAIR---------LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 401 DMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQW 460
D + DD ++++ E L+ + A +A L E+E ++ L E+TE S
Sbjct: 1658 DTQIHLDDALRSQ---EDLKEQLAMVERRANLLQAEIEELRATL------EQTERS---- 1704
Query: 461 LFKRLQEEEAKSGHLSREVDALKEK----IHEYMATEDLICHLQGD-HSVLQKKLNQQEN 515
+++ E+E S V L + I+ E I +QG+ +LQ+ N +E
Sbjct: 1705 --RKIAEQELLDA--SERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEK 1760
Query: 516 RNR---DLGREIENLTKELERYRHFSK 539
+ D E L KE + H +
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLER 1787
Score = 92.8 bits (229), Expect = 1e-18
Identities = 119/565 (21%), Positives = 252/565 (44%), Gaps = 72/565 (12%)
Query: 9 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 68
L L +++ +L ++ L LA+ + + E + +L+++L+ + +
Sbjct: 1040 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI----SN 1095
Query: 69 IMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGI 128
+ +K+ +E + QLQ+K+ L +I+EL EEE++ + +K E + +
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEEL----------EEEIEAERASRAKAEKQRSDL 1145
Query: 129 MAEVEELRKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQSKDFKLEVEKLSKRI 184
E+EE+ +R+ + G I+M E + + + + LE TLQ + + K K
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK--KHA 1203
Query: 185 MALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEF 244
++ +L + + ++ +K LEKE+ ++ E++ L ++ + + LEK
Sbjct: 1204 DSVAELGEQIDNLQR----VKQKLEKEK---SEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 245 TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETK 304
TL++ L++L K+ E+ ++ + L A +LQ E + + ++ K
Sbjct: 1257 TLEDQLSEL-----------KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE-----K 1300
Query: 305 RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EAIEKDF 362
AL S+ ++ + T++ ++LK +L+ E + N L + ++ L + E+
Sbjct: 1301 EALVSQLSRGKQAF--TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358
Query: 363 LKNKLNQDSGKSTTALHQENNKIK----ELSQEVERLKLKLKDMKAIEDDLMKTEDEYET 418
K +L + K+ T + Q K + + ++E+E K KL L E+ E
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR------LQAAEEHVEA 1412
Query: 419 LERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSRE 478
+ + A+ Q L E+E + +++ + A ++ K L E + K E
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1472
Query: 479 VDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFS 538
++A +K + TE + S+ Q + ++EN+N L +EI +LT+++
Sbjct: 1473 LEA-SQKEARSLGTELFKIKNAYEESLDQLETLKRENKN--LQQEISDLTEQIAE----- 1524
Query: 539 KSLRPSLNGRRISDPQVFSKEVQTE 563
G+RI + + K+V+ E
Sbjct: 1525 -------GGKRIHELEKIKKQVEQE 1542
Score = 64.7 bits (156), Expect = 4e-10
Identities = 96/500 (19%), Positives = 203/500 (40%), Gaps = 79/500 (15%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 62
+D+ + L + +Q+I +LT E ++ E ++ EQ+ L+ L+
Sbjct: 1498 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL 1557
Query: 63 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE 122
++ I+ + ++ +K+A +ID+L+ + + ++ + D
Sbjct: 1558 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD--------- 1608
Query: 123 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQS--------KDFK 174
AE+ + + + +L +ME Q N R+ E L++ KD +
Sbjct: 1609 -------AEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN-RMAAEALRNYRNTQGILKDTQ 1660
Query: 175 LEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
+ ++ + L++ +E N + E L+ LE+ + K QEL R++
Sbjct: 1661 IHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1720
Query: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 290
L + L T+ L+ D+++++ + E + EK KK + +L+ EQ+
Sbjct: 1721 LLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQD 1780
Query: 291 KVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
+ +K +E+T + L+ + D E++ LK +++ L +RV L
Sbjct: 1781 TSAHLERMKKNMEQTVKDLQLRLDEAEQL------------ALKGGKKQIQKLEARVREL 1828
Query: 349 KNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDD 408
+ ++S + K N ++ K L + ++KEL+ + E + + ++ + D
Sbjct: 1829 EGEVES---------EQKRNAEAVK---GLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 409 LMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEE 468
L Y +R A E + E LAK++ + HE L+E
Sbjct: 1877 LQAKVKSY----KRQAEEAE---------EQSNTNLAKFR-----KLQHE------LEEA 1912
Query: 469 EAKSGHLSREVDALKEKIHE 488
E ++ +V+ L+ K E
Sbjct: 1913 EERADIAESQVNKLRVKSRE 1932
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 111 bits (278), Expect = 3e-24
Identities = 137/583 (23%), Positives = 252/583 (43%), Gaps = 77/583 (13%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
D Q L+ ++ QE+T K + EA+VQE QK + +EL Q +F
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
+ + + + +N L +L L + E+E +K E ++Q+++ K S GE
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGER 1273
Query: 124 GNAGIMAEVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ--- 169
A + +V +L+ V + EGK +L K + Q +D + L+ ET Q
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 170 --SKDFKLEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMT 214
+K +LE E+ S + E++E N SK++ +E
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 215 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 274
K+ +E+E+L + +E A +LEKT+ L+++L L V+ +D ++ + L+K
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKK 1449
Query: 275 EDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAE 334
+ K QL E+ +++ K +E RA + E K S+ + L+ L+A+
Sbjct: 1450 QRKF----DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAK 1499
Query: 335 EEKGNDLLSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQE 391
EE L R N MLK ++ L + + D KN +L + T + + +++EL E
Sbjct: 1500 EE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 392 VE-------RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQF 432
++ RL++ ++ +K E DL +++ E R+ +ER +
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 433 LSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 492
+ + ++ +L +L + + K+L++ +A+ RE++ + E AT
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 493 ----EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
E L+ D LQ+ L E + E E L +EL
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Score = 107 bits (266), Expect = 6e-23
Identities = 126/541 (23%), Positives = 233/541 (43%), Gaps = 49/541 (9%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQ 58
+D Q++L + L +++K +L K +K A AEA +E+E KA L + L+
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 59 T-TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQD 113
K ++ M K ED L + + + ELE++ R+L EE L++
Sbjct: 1496 LEAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 114 IKEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+++++ E + ++ L+ + D++ +DE+ EE+ R L ++L + +D
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELED 1607
Query: 173 FKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 225
+ + +KL + LE D+ K ++E L K + K +ELE
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDA 1664
Query: 226 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS-- 283
+ E+ A EK +L+ DL +L+ + ER L+K E + ASS
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLS 1722
Query: 284 ---QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE----- 335
LQ E+ ++ +L EE + + + +++ T++ + L N+L E
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 336 -EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 393
E L R N L+++L +E K K+ + K Q + +E +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 394 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKT 453
LK K K +K I L++ EDE + E+ Y + +K K+L K +L + + +
Sbjct: 1843 SLKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQR 1895
Query: 454 ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 513
++ + L + L E + + REV+ALK K+ T + G V++ +
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSE 1955
Query: 514 E 514
E
Sbjct: 1956 E 1956
Score = 106 bits (264), Expect = 1e-22
Identities = 126/586 (21%), Positives = 257/586 (43%), Gaps = 65/586 (11%)
Query: 5 EQQRLTAQLTLQRQKIQ-------ELTTNAKETHTKLAL-----------AEARVQEEEQ 46
E ++ +QLT ++ +Q EL A+E +LA EAR++EEE
Sbjct: 877 ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED 936
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEE----TNR 102
+ ++LQ + K Q + +L E++ ++LQ + +I +LE+ +
Sbjct: 937 RG----QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 103 SLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI-------KMEEQ 155
K +E + ++E+IS +AE EE K + ++ K E +I K EE+
Sbjct: 993 QNNKLSKERKLLEERISDLTTN----LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048
Query: 156 CRDLNKRLERETL-QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT 214
R ++L+R+ + DF ++ L +I L K++ A K ++E + L+ E
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAEL-KMQLA--KKEEELQAALARLDDEIAQ 1105
Query: 215 TKQLSQELESLKVRIKELE-------AIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTM 267
+++ L+ I +L+ A ++ EK + L E+L LKT +D T
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 268 SEKLKKTE-----------DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 316
E K E ++ ++ +Q+Q + K E+L E+ ++ ++K ++++
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 317 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 376
++ KE DL +L+ + ++ + L+ ++Q L++ D + +
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD--GERARAELNDKVH 1283
Query: 377 ALHQENNKIKELSQEVERLKLKL-KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 435
L E + + E E +KL KD+ ++ L T++ + R+ N K + L +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1343
Query: 436 ELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 495
E ++ +L + A++ H L +L + + K + V+AL+E + +
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1403
Query: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSL 541
+ + + KL + +NR L +E+++L +L+ R +L
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNL 1446
Score = 100 bits (250), Expect = 5e-21
Identities = 128/551 (23%), Positives = 245/551 (44%), Gaps = 66/551 (11%)
Query: 6 QQRLTAQLTLQRQ-----KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
QQ+LTA +QR K++ T K L R QEEE +A E ELQ +T
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR-QEEEMQAK--EDELQ-KTK 865
Query: 61 KFHQDQDTIMAKLTNEDSQNRQ----LQQKLAALSRQIDELEETNRSLRKAEEELQDI-- 114
+ Q + + +L + SQ + LQ++L A + E EE L ++EL++I
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 115 --KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+ ++ + E + AE +++ +++LD+E + EE EE R +LE+ T ++K
Sbjct: 926 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----EEAARQ-KLQLEKVTAEAK- 979
Query: 173 FKLEVEKLSKRIMALEKLEDAFNKSK----QECYSLKCNLEKERMTTKQLSQ-------E 221
++KL I+ ++ + +K + + L NL +E K L++
Sbjct: 980 ----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Query: 222 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 281
+ L+VR+K+ E LEK + L+ D + + + +L K E++LQAA
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 282 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 341
++L E I + ALK ++E + + ++ D + E++ DL
Sbjct: 1096 LARLDDE-----------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 342 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 401
+ LK L+ + ++ + +L + T L + ++ + S E + +++ K
Sbjct: 1145 GEELEALKTELE--DTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKH 1201
Query: 402 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWL 461
+A+E+ ++ E +R AN Q L KE + EL A++ ++ L
Sbjct: 1202 AQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 462 FKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLG 521
++QE ++K R L +K+H+ LQ + + LN+ E + L
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHK----------LQNEVESVTGMLNEAEGKAIKLA 1307
Query: 522 REIENLTKELE 532
+++ +L+ +L+
Sbjct: 1308 KDVASLSSQLQ 1318
Score = 77.4 bits (189), Expect = 5e-14
Identities = 95/426 (22%), Positives = 187/426 (43%), Gaps = 55/426 (12%)
Query: 179 KLSKRIMALEKL------EDAFNKSKQECYSLKC------------NLEKERMTTK---- 216
K++ IMA + + AF K +Q+ ++K N + R+ TK
Sbjct: 785 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 844
Query: 217 -QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTE 275
Q++++ E ++ + EL+ + R +K E LKE K LT E K + ++ + E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT-----EEKNLLQEQLQAE 899
Query: 276 DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD----DLKNKL 331
+L A + +++V E+++ E + L+ + D +++ + K+ DL+ +L
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 332 KAEEEKGNDLLSRVNMLKNRLQSLE--AIEKDFLKNKLNQDS-------GKSTTALHQEN 382
+ EE L + +++ LE + D NKL+++ TT L +E
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 383 NKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKM 442
K K L++ + + + +++ K+ E E L+R+ E D + F +++ ++
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL--EGDASDF-HEQIADLQA 1076
Query: 443 ELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGD 502
++A+ K+ + Q RL +E A+ + +++ L+ I + LQ D
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD----------LQED 1126
Query: 503 HSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQT 562
+ N+ E + RDLG E+E L ELE S + + L +R + V K +
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDE 1185
Query: 563 EAVDNE 568
E +E
Sbjct: 1186 ETRSHE 1191
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 111 bits (278), Expect = 3e-24
Identities = 137/583 (23%), Positives = 252/583 (43%), Gaps = 77/583 (13%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
D Q L+ ++ QE+T K + EA+VQE QK + +EL Q +F
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
+ + + + +N L +L L + E+E +K E ++Q+++ K S GE
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGER 1280
Query: 124 GNAGIMAEVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ--- 169
A + +V +L+ V + EGK +L K + Q +D + L+ ET Q
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 170 --SKDFKLEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMT 214
+K +LE E+ S + E++E N SK++ +E
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 215 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 274
K+ +E+E+L + +E A +LEKT+ L+++L L V+ +D ++ + L+K
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKK 1456
Query: 275 EDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAE 334
+ K QL E+ +++ K +E RA + E K S+ + L+ L+A+
Sbjct: 1457 QRKF----DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAK 1506
Query: 335 EEKGNDLLSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQE 391
EE L R N MLK ++ L + + D KN +L + T + + +++EL E
Sbjct: 1507 EE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 392 VE-------RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQF 432
++ RL++ ++ +K E DL +++ E R+ +ER +
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 433 LSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 492
+ + ++ +L +L + + K+L++ +A+ RE++ + E AT
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 493 ----EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
E L+ D LQ+ L E + E E L +EL
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Score = 107 bits (266), Expect = 6e-23
Identities = 126/541 (23%), Positives = 233/541 (43%), Gaps = 49/541 (9%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQ 58
+D Q++L + L +++K +L K +K A AEA +E+E KA L + L+
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 59 T-TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQD 113
K ++ M K ED L + + + ELE++ R+L EE L++
Sbjct: 1503 LEAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 114 IKEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+++++ E + ++ L+ + D++ +DE+ EE+ R L ++L + +D
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELED 1614
Query: 173 FKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 225
+ + +KL + LE D+ K ++E L K + K +ELE
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDA 1671
Query: 226 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS-- 283
+ E+ A EK +L+ DL +L+ + ER L+K E + ASS
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLS 1729
Query: 284 ---QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE----- 335
LQ E+ ++ +L EE + + + +++ T++ + L N+L E
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 336 -EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 393
E L R N L+++L +E K K+ + K Q + +E +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 394 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKT 453
LK K K +K I L++ EDE + E+ Y + +K K+L K +L + + +
Sbjct: 1850 SLKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQR 1902
Query: 454 ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 513
++ + L + L E + + REV+ALK K+ T + G V++ +
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSE 1962
Query: 514 E 514
E
Sbjct: 1963 E 1963
Score = 106 bits (264), Expect = 1e-22
Identities = 126/586 (21%), Positives = 257/586 (43%), Gaps = 65/586 (11%)
Query: 5 EQQRLTAQLTLQRQKIQ-------ELTTNAKETHTKLAL-----------AEARVQEEEQ 46
E ++ +QLT ++ +Q EL A+E +LA EAR++EEE
Sbjct: 884 ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED 943
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEE----TNR 102
+ ++LQ + K Q + +L E++ ++LQ + +I +LE+ +
Sbjct: 944 RG----QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 103 SLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI-------KMEEQ 155
K +E + ++E+IS +AE EE K + ++ K E +I K EE+
Sbjct: 1000 QNNKLSKERKLLEERISDLTTN----LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055
Query: 156 CRDLNKRLERETL-QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT 214
R ++L+R+ + DF ++ L +I L K++ A K ++E + L+ E
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAEL-KMQLA--KKEEELQAALARLDDEIAQ 1112
Query: 215 TKQLSQELESLKVRIKELE-------AIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTM 267
+++ L+ I +L+ A ++ EK + L E+L LKT +D T
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 268 SEKLKKTE-----------DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 316
E K E ++ ++ +Q+Q + K E+L E+ ++ ++K ++++
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 317 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 376
++ KE DL +L+ + ++ + L+ ++Q L++ D + +
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD--GERARAELNDKVH 1290
Query: 377 ALHQENNKIKELSQEVERLKLKL-KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 435
L E + + E E +KL KD+ ++ L T++ + R+ N K + L +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1350
Query: 436 ELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 495
E ++ +L + A++ H L +L + + K + V+AL+E + +
Sbjct: 1351 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1410
Query: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSL 541
+ + + KL + +NR L +E+++L +L+ R +L
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNL 1453
Score = 100 bits (250), Expect = 5e-21
Identities = 128/551 (23%), Positives = 245/551 (44%), Gaps = 66/551 (11%)
Query: 6 QQRLTAQLTLQRQ-----KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
QQ+LTA +QR K++ T K L R QEEE +A E ELQ +T
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR-QEEEMQAK--EDELQ-KTK 872
Query: 61 KFHQDQDTIMAKLTNEDSQNRQ----LQQKLAALSRQIDELEETNRSLRKAEEELQDI-- 114
+ Q + + +L + SQ + LQ++L A + E EE L ++EL++I
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 115 --KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+ ++ + E + AE +++ +++LD+E + EE EE R +LE+ T ++K
Sbjct: 933 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----EEAARQ-KLQLEKVTAEAK- 986
Query: 173 FKLEVEKLSKRIMALEKLEDAFNKSK----QECYSLKCNLEKERMTTKQLSQ-------E 221
++KL I+ ++ + +K + + L NL +E K L++
Sbjct: 987 ----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Query: 222 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 281
+ L+VR+K+ E LEK + L+ D + + + +L K E++LQAA
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 282 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 341
++L E I + ALK ++E + + ++ D + E++ DL
Sbjct: 1103 LARLDDE-----------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 342 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 401
+ LK L+ + ++ + +L + T L + ++ + S E + +++ K
Sbjct: 1152 GEELEALKTELE--DTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKH 1208
Query: 402 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWL 461
+A+E+ ++ E +R AN Q L KE + EL A++ ++ L
Sbjct: 1209 AQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 462 FKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLG 521
++QE ++K R L +K+H+ LQ + + LN+ E + L
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHK----------LQNEVESVTGMLNEAEGKAIKLA 1314
Query: 522 REIENLTKELE 532
+++ +L+ +L+
Sbjct: 1315 KDVASLSSQLQ 1325
Score = 77.4 bits (189), Expect = 5e-14
Identities = 95/426 (22%), Positives = 187/426 (43%), Gaps = 55/426 (12%)
Query: 179 KLSKRIMALEKL------EDAFNKSKQECYSLKC------------NLEKERMTTK---- 216
K++ IMA + + AF K +Q+ ++K N + R+ TK
Sbjct: 792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 851
Query: 217 -QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTE 275
Q++++ E ++ + EL+ + R +K E LKE K LT E K + ++ + E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT-----EEKNLLQEQLQAE 906
Query: 276 DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD----DLKNKL 331
+L A + +++V E+++ E + L+ + D +++ + K+ DL+ +L
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 332 KAEEEKGNDLLSRVNMLKNRLQSLE--AIEKDFLKNKLNQDS-------GKSTTALHQEN 382
+ EE L + +++ LE + D NKL+++ TT L +E
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 383 NKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKM 442
K K L++ + + + +++ K+ E E L+R+ E D + F +++ ++
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL--EGDASDF-HEQIADLQA 1083
Query: 443 ELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGD 502
++A+ K+ + Q RL +E A+ + +++ L+ I + LQ D
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD----------LQED 1133
Query: 503 HSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQT 562
+ N+ E + RDLG E+E L ELE S + + L +R + V K +
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDE 1192
Query: 563 EAVDNE 568
E +E
Sbjct: 1193 ETRSHE 1198
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 111 bits (278), Expect = 3e-24
Identities = 137/583 (23%), Positives = 252/583 (43%), Gaps = 77/583 (13%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
D Q L+ ++ QE+T K + EA+VQE QK + +EL Q +F
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1223
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
+ + + + +N L +L L + E+E +K E ++Q+++ K S GE
Sbjct: 1224 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGER 1280
Query: 124 GNAGIMAEVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ--- 169
A + +V +L+ V + EGK +L K + Q +D + L+ ET Q
Sbjct: 1281 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 170 --SKDFKLEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMT 214
+K +LE E+ S + E++E N SK++ +E
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1400
Query: 215 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 274
K+ +E+E+L + +E A +LEKT+ L+++L L V+ +D ++ + L+K
Sbjct: 1401 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKK 1456
Query: 275 EDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAE 334
+ K QL E+ +++ K +E RA + E K S+ + L+ L+A+
Sbjct: 1457 QRKF----DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAK 1506
Query: 335 EEKGNDLLSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQE 391
EE L R N MLK ++ L + + D KN +L + T + + +++EL E
Sbjct: 1507 EE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 392 VE-------RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQF 432
++ RL++ ++ +K E DL +++ E R+ +ER +
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 433 LSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 492
+ + ++ +L +L + + K+L++ +A+ RE++ + E AT
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 493 ----EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
E L+ D LQ+ L E + E E L +EL
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Score = 106 bits (264), Expect = 1e-22
Identities = 126/586 (21%), Positives = 257/586 (43%), Gaps = 65/586 (11%)
Query: 5 EQQRLTAQLTLQRQKIQ-------ELTTNAKETHTKLAL-----------AEARVQEEEQ 46
E ++ +QLT ++ +Q EL A+E +LA EAR++EEE
Sbjct: 884 ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED 943
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEE----TNR 102
+ ++LQ + K Q + +L E++ ++LQ + +I +LE+ +
Sbjct: 944 RG----QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 103 SLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI-------KMEEQ 155
K +E + ++E+IS +AE EE K + ++ K E +I K EE+
Sbjct: 1000 QNNKLSKERKLLEERISDLTTN----LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055
Query: 156 CRDLNKRLERETL-QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT 214
R ++L+R+ + DF ++ L +I L K++ A K ++E + L+ E
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAEL-KMQLA--KKEEELQAALARLDDEIAQ 1112
Query: 215 TKQLSQELESLKVRIKELE-------AIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTM 267
+++ L+ I +L+ A ++ EK + L E+L LKT +D T
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 268 SEKLKKTE-----------DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 316
E K E ++ ++ +Q+Q + K E+L E+ ++ ++K ++++
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 317 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 376
++ KE DL +L+ + ++ + L+ ++Q L++ D + +
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD--GERARAELNDKVH 1290
Query: 377 ALHQENNKIKELSQEVERLKLKL-KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 435
L E + + E E +KL KD+ ++ L T++ + R+ N K + L +
Sbjct: 1291 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1350
Query: 436 ELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 495
E ++ +L + A++ H L +L + + K + V+AL+E + +
Sbjct: 1351 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1410
Query: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSL 541
+ + + KL + +NR L +E+++L +L+ R +L
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNL 1453
Score = 105 bits (261), Expect = 2e-22
Identities = 122/513 (23%), Positives = 225/513 (43%), Gaps = 49/513 (9%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQ 58
+D Q++L + L +++K +L K +K A AEA +E+E KA L + L+
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 59 T-TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQD 113
K ++ M K ED L + + + ELE++ R+L EE L++
Sbjct: 1503 LEAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 114 IKEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+++++ E + ++ L+ + D++ +DE+ EE+ R L ++L + +D
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELED 1614
Query: 173 FKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 225
+ + +KL + LE D+ K ++E L K + K +ELE
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDA 1671
Query: 226 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS-- 283
+ E+ A EK +L+ DL +L+ + ER L+K E + ASS
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLS 1729
Query: 284 ---QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE----- 335
LQ E+ ++ +L EE + + + +++ T++ + L N+L E
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 336 -EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 393
E L R N L+++L +E K K+ + K Q + +E +
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1849
Query: 394 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKT 453
LK K K +K I L++ EDE + E+ Y + +K K+L K +L + + +
Sbjct: 1850 SLKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQR 1902
Query: 454 ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 486
++ + L + L E + + REV+ALK K+
Sbjct: 1903 INANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 100 bits (250), Expect = 5e-21
Identities = 128/551 (23%), Positives = 245/551 (44%), Gaps = 66/551 (11%)
Query: 6 QQRLTAQLTLQRQ-----KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
QQ+LTA +QR K++ T K L R QEEE +A E ELQ +T
Sbjct: 817 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR-QEEEMQAK--EDELQ-KTK 872
Query: 61 KFHQDQDTIMAKLTNEDSQNRQ----LQQKLAALSRQIDELEETNRSLRKAEEELQDI-- 114
+ Q + + +L + SQ + LQ++L A + E EE L ++EL++I
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 932
Query: 115 --KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+ ++ + E + AE +++ +++LD+E + EE EE R +LE+ T ++K
Sbjct: 933 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----EEAARQ-KLQLEKVTAEAK- 986
Query: 173 FKLEVEKLSKRIMALEKLEDAFNKSK----QECYSLKCNLEKERMTTKQLSQ-------E 221
++KL I+ ++ + +K + + L NL +E K L++
Sbjct: 987 ----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1042
Query: 222 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 281
+ L+VR+K+ E LEK + L+ D + + + +L K E++LQAA
Sbjct: 1043 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 282 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 341
++L E I + ALK ++E + + ++ D + E++ DL
Sbjct: 1103 LARLDDE-----------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 342 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 401
+ LK L+ + ++ + +L + T L + ++ + S E + +++ K
Sbjct: 1152 GEELEALKTELE--DTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKH 1208
Query: 402 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWL 461
+A+E+ ++ E +R AN Q L KE + EL A++ ++ L
Sbjct: 1209 AQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 462 FKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLG 521
++QE ++K R L +K+H+ LQ + + LN+ E + L
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHK----------LQNEVESVTGMLNEAEGKAIKLA 1314
Query: 522 REIENLTKELE 532
+++ +L+ +L+
Sbjct: 1315 KDVASLSSQLQ 1325
Score = 77.4 bits (189), Expect = 5e-14
Identities = 95/426 (22%), Positives = 187/426 (43%), Gaps = 55/426 (12%)
Query: 179 KLSKRIMALEKL------EDAFNKSKQECYSLKC------------NLEKERMTTK---- 216
K++ IMA + + AF K +Q+ ++K N + R+ TK
Sbjct: 792 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 851
Query: 217 -QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTE 275
Q++++ E ++ + EL+ + R +K E LKE K LT E K + ++ + E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT-----EEKNLLQEQLQAE 906
Query: 276 DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD----DLKNKL 331
+L A + +++V E+++ E + L+ + D +++ + K+ DL+ +L
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 332 KAEEEKGNDLLSRVNMLKNRLQSLE--AIEKDFLKNKLNQDS-------GKSTTALHQEN 382
+ EE L + +++ LE + D NKL+++ TT L +E
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 383 NKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKM 442
K K L++ + + + +++ K+ E E L+R+ E D + F +++ ++
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL--EGDASDF-HEQIADLQA 1083
Query: 443 ELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGD 502
++A+ K+ + Q RL +E A+ + +++ L+ I + LQ D
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD----------LQED 1133
Query: 503 HSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQT 562
+ N+ E + RDLG E+E L ELE S + + L +R + V K +
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDE 1192
Query: 563 EAVDNE 568
E +E
Sbjct: 1193 ETRSHE 1198
Score = 68.6 bits (166), Expect = 3e-11
Identities = 84/405 (20%), Positives = 164/405 (40%), Gaps = 92/405 (22%)
Query: 15 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 74
L++ K + L T +E T+L E +Q E RLE +Q +F +D + A+
Sbjct: 1537 LEKSK-RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD---LQARDE 1592
Query: 75 NEDSQNRQLQQKLAALSRQIDE--------------------------------LEETNR 102
+ + RQLQ++L ++++ EE +
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 103 SLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL------------- 149
LRK + +++D + ++ I A +E K+ +E +L
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 150 --IKMEEQCRDLNKRLE-RETLQSKDFKLEV------EKLSKRIMALEKLEDAFNKSKQE 200
++ EE +L L R LQ + +LE E+L + +E + D K+ Q+
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 201 CYSLKCNLEKERMTTK-------QLSQELESLKVRIKELE------------AIESRLEK 241
L L ER T + QL ++ + L+ ++ E+E A+E+++ +
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 242 TEF--------------TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 287
E +LK+ KLK + + DERK M+E+ K+ +K A QL+
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-MAEQYKEQAEKGNARVKQLKR 1891
Query: 288 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 332
+ + ++++ ++ + + E ++ +E + LK+KL+
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 111 bits (278), Expect = 3e-24
Identities = 137/583 (23%), Positives = 252/583 (43%), Gaps = 77/583 (13%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
D Q L+ ++ QE+T K + EA+VQE QK + +EL Q +F
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK 1216
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
+ + + + +N L +L L + E+E +K E ++Q+++ K S GE
Sbjct: 1217 RAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGER 1273
Query: 124 GNAGIMAEVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ--- 169
A + +V +L+ V + EGK +L K + Q +D + L+ ET Q
Sbjct: 1274 ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 170 --SKDFKLEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMT 214
+K +LE E+ S + E++E N SK++ +E
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEG 1393
Query: 215 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 274
K+ +E+E+L + +E A +LEKT+ L+++L L V+ +D ++ + L+K
Sbjct: 1394 KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKK 1449
Query: 275 EDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAE 334
+ K QL E+ +++ K +E RA + E K S+ + L+ L+A+
Sbjct: 1450 QRKF----DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAK 1499
Query: 335 EEKGNDLLSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQE 391
EE L R N MLK ++ L + + D KN +L + T + + +++EL E
Sbjct: 1500 EE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 392 VE-------RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQF 432
++ RL++ ++ +K E DL +++ E R+ +ER +
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 433 LSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT 492
+ + ++ +L +L + + K+L++ +A+ RE++ + E AT
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 493 ----EDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
E L+ D LQ+ L E + E E L +EL
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Score = 106 bits (264), Expect = 1e-22
Identities = 126/586 (21%), Positives = 257/586 (43%), Gaps = 65/586 (11%)
Query: 5 EQQRLTAQLTLQRQKIQ-------ELTTNAKETHTKLAL-----------AEARVQEEEQ 46
E ++ +QLT ++ +Q EL A+E +LA EAR++EEE
Sbjct: 877 ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED 936
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEE----TNR 102
+ ++LQ + K Q + +L E++ ++LQ + +I +LE+ +
Sbjct: 937 RG----QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 103 SLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI-------KMEEQ 155
K +E + ++E+IS +AE EE K + ++ K E +I K EE+
Sbjct: 993 QNNKLSKERKLLEERISDLTTN----LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048
Query: 156 CRDLNKRLERETL-QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT 214
R ++L+R+ + DF ++ L +I L K++ A K ++E + L+ E
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAEL-KMQLA--KKEEELQAALARLDDEIAQ 1105
Query: 215 TKQLSQELESLKVRIKELE-------AIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTM 267
+++ L+ I +L+ A ++ EK + L E+L LKT +D T
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 268 SEKLKKTE-----------DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK 316
E K E ++ ++ +Q+Q + K E+L E+ ++ ++K ++++
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 317 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT 376
++ KE DL +L+ + ++ + L+ ++Q L++ D + +
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD--GERARAELNDKVH 1283
Query: 377 ALHQENNKIKELSQEVERLKLKL-KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 435
L E + + E E +KL KD+ ++ L T++ + R+ N K + L +
Sbjct: 1284 KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEE 1343
Query: 436 ELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 495
E ++ +L + A++ H L +L + + K + V+AL+E + +
Sbjct: 1344 ERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIEN 1403
Query: 496 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSL 541
+ + + KL + +NR L +E+++L +L+ R +L
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNL 1446
Score = 105 bits (261), Expect = 2e-22
Identities = 122/513 (23%), Positives = 225/513 (43%), Gaps = 49/513 (9%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQ 58
+D Q++L + L +++K +L K +K A AEA +E+E KA L + L+
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 59 T-TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQD 113
K ++ M K ED L + + + ELE++ R+L EE L++
Sbjct: 1496 LEAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 114 IKEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+++++ E + ++ L+ + D++ +DE+ EE+ R L ++L + +D
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELED 1607
Query: 173 FKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 225
+ + +KL + LE D+ K ++E L K + K +ELE
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDA 1664
Query: 226 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS-- 283
+ E+ A EK +L+ DL +L+ + ER L+K E + ASS
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLS 1722
Query: 284 ---QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE----- 335
LQ E+ ++ +L EE + + + +++ T++ + L N+L E
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 336 -EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 393
E L R N L+++L +E K K+ + K Q + +E +
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATK 1842
Query: 394 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKT 453
LK K K +K I L++ EDE + E+ Y + +K K+L K +L + + +
Sbjct: 1843 SLKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQR 1895
Query: 454 ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 486
++ + L + L E + + REV+ALK K+
Sbjct: 1896 INANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 100 bits (250), Expect = 5e-21
Identities = 128/551 (23%), Positives = 245/551 (44%), Gaps = 66/551 (11%)
Query: 6 QQRLTAQLTLQRQ-----KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
QQ+LTA +QR K++ T K L R QEEE +A E ELQ +T
Sbjct: 810 QQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR-QEEEMQAK--EDELQ-KTK 865
Query: 61 KFHQDQDTIMAKLTNEDSQNRQ----LQQKLAALSRQIDELEETNRSLRKAEEELQDI-- 114
+ Q + + +L + SQ + LQ++L A + E EE L ++EL++I
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILH 925
Query: 115 --KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+ ++ + E + AE +++ +++LD+E + EE EE R +LE+ T ++K
Sbjct: 926 EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE----EEAARQ-KLQLEKVTAEAK- 979
Query: 173 FKLEVEKLSKRIMALEKLEDAFNKSK----QECYSLKCNLEKERMTTKQLSQ-------E 221
++KL I+ ++ + +K + + L NL +E K L++
Sbjct: 980 ----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM 1035
Query: 222 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 281
+ L+VR+K+ E LEK + L+ D + + + +L K E++LQAA
Sbjct: 1036 ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 282 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 341
++L E I + ALK ++E + + ++ D + E++ DL
Sbjct: 1096 LARLDDE-----------IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 342 LSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD 401
+ LK L+ + ++ + +L + T L + ++ + S E + +++ K
Sbjct: 1145 GEELEALKTELE--DTLDSTATQQELRAKREQEVTVLKKALDE-ETRSHEAQVQEMRQKH 1201
Query: 402 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWL 461
+A+E+ ++ E +R AN Q L KE + EL A++ ++ L
Sbjct: 1202 AQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 462 FKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLG 521
++QE ++K R L +K+H+ LQ + + LN+ E + L
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHK----------LQNEVESVTGMLNEAEGKAIKLA 1307
Query: 522 REIENLTKELE 532
+++ +L+ +L+
Sbjct: 1308 KDVASLSSQLQ 1318
Score = 77.4 bits (189), Expect = 5e-14
Identities = 95/426 (22%), Positives = 187/426 (43%), Gaps = 55/426 (12%)
Query: 179 KLSKRIMALEKL------EDAFNKSKQECYSLKC------------NLEKERMTTK---- 216
K++ IMA + + AF K +Q+ ++K N + R+ TK
Sbjct: 785 KITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPL 844
Query: 217 -QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTE 275
Q++++ E ++ + EL+ + R +K E LKE K LT E K + ++ + E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT-----EEKNLLQEQLQAE 899
Query: 276 DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD----DLKNKL 331
+L A + +++V E+++ E + L+ + D +++ + K+ DL+ +L
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 332 KAEEEKGNDLLSRVNMLKNRLQSLE--AIEKDFLKNKLNQDS-------GKSTTALHQEN 382
+ EE L + +++ LE + D NKL+++ TT L +E
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 383 NKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKM 442
K K L++ + + + +++ K+ E E L+R+ E D + F +++ ++
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL--EGDASDF-HEQIADLQA 1076
Query: 443 ELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGD 502
++A+ K+ + Q RL +E A+ + +++ L+ I + LQ D
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD----------LQED 1126
Query: 503 HSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQT 562
+ N+ E + RDLG E+E L ELE S + + L +R + V K +
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDE 1185
Query: 563 EAVDNE 568
E +E
Sbjct: 1186 ETRSHE 1191
Score = 68.6 bits (166), Expect = 3e-11
Identities = 84/405 (20%), Positives = 164/405 (40%), Gaps = 92/405 (22%)
Query: 15 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 74
L++ K + L T +E T+L E +Q E RLE +Q +F +D + A+
Sbjct: 1530 LEKSK-RALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD---LQARDE 1585
Query: 75 NEDSQNRQLQQKLAALSRQIDE--------------------------------LEETNR 102
+ + RQLQ++L ++++ EE +
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 103 SLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL------------- 149
LRK + +++D + ++ I A +E K+ +E +L
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 150 --IKMEEQCRDLNKRLE-RETLQSKDFKLEV------EKLSKRIMALEKLEDAFNKSKQE 200
++ EE +L L R LQ + +LE E+L + +E + D K+ Q+
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 201 CYSLKCNLEKERMTTK-------QLSQELESLKVRIKELE------------AIESRLEK 241
L L ER T + QL ++ + L+ ++ E+E A+E+++ +
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 242 TEF--------------TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 287
E +LK+ KLK + + DERK M+E+ K+ +K A QL+
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-MAEQYKEQAEKGNARVKQLKR 1884
Query: 288 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 332
+ + ++++ ++ + + E ++ +E + LK+KL+
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 111 bits (277), Expect = 3e-24
Identities = 145/632 (22%), Positives = 270/632 (42%), Gaps = 122/632 (19%)
Query: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK------- 53
++ D T LT + +K + L + + E R++ EE++ LEK
Sbjct: 996 LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG 1055
Query: 54 -----------------ELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 96
EL+ Q K ++ +A++ E +Q +K+ L QI E
Sbjct: 1056 DSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE 1115
Query: 97 LEETNRSLR----KAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL-IK 151
L+E S R KAE++ +D+ E++ + E+E+ LD +EL K
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELE-------ALKTELED----TLDSTAAQQELRSK 1164
Query: 152 MEEQCRDLNKRLERETLQSKDFKLEVEKL-SKRIMALEKLEDAFNKSKQECYSLKCNLEK 210
E++ L K LE E +K + +++++ K A+E+L + ++K+ +K NLEK
Sbjct: 1165 REQEVNILKKTLEEE---AKTHEAQIQEMRQKHSQAVEELAEQLEQTKR----VKANLEK 1217
Query: 211 ERMTTKQLSQEL-ESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 269
+ T + EL +KV ++ E + +K E L+E L V F + + +E
Sbjct: 1218 AKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE-------LQVKFNEGERVRTE 1270
Query: 270 ------KLKKTEDKLQAASSQLQVEQNKVT---TVTEKLIEETKRAL----KSKTDVEEK 316
KL+ D + SQ + +K+T + E +++T+ L + K + K
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 317 MYSVTKERDDLKNKLKAEEEKGNDLLSRV--------NMLKNRLQSLEAIE-KDFLKNKL 367
+ V E++ + +L+ EEE ++L ++ +M K S+ +E + +K KL
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKL 1390
Query: 368 NQD------SGKSTTALHQENNKIK-ELSQEVERLKLKLKDMKAIEDDLMKTEDEYE--- 417
+D + A + + K K L QE++ L + L + +L K + +++
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 418 ----TLERRYANERDKAQFLSKELEHVKMELAK------------YKLAEKTETSHEQWL 461
T+ +YA ERD+A+ ++E E + LA+ +L ++ T E +
Sbjct: 1451 AEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510
Query: 462 F------KRLQEEEAKSGHLSREVDALKEKIH----EYMATEDLICHLQGDHSV------ 505
K + E E L ++V+ +K ++ E ATED L+ +
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 506 --LQKKLNQQENRNRDLGREIENLTKELERYR 535
LQ + Q E + + L R++ + ELE R
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Score = 102 bits (255), Expect = 1e-21
Identities = 142/566 (25%), Positives = 246/566 (43%), Gaps = 68/566 (12%)
Query: 6 QQRLTAQLTLQRQ-----KIQELTTNAKETHTKLALAEARVQEEEQKATRLE----KELQ 56
QQ+LTA LQR K++ T K L +R QEEE A E +E Q
Sbjct: 803 QQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSR-QEEEMMAKEEELVKVREKQ 861
Query: 57 TQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ---- 112
+ +T+ ++L E QLQ++L A + E EE L ++EL+
Sbjct: 862 LAAENRLTEMETLQSQLMAE---KLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 918
Query: 113 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
D++ ++ + E + AE +++++ + ++E + EE EE R +LE+ T ++K
Sbjct: 919 DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE----EESARQ-KLQLEKVTTEAKL 973
Query: 173 FKLEVE---------KLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE 223
KLE E KL+K LE F + E +L K + + + +LE
Sbjct: 974 KKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLE 1033
Query: 224 SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS 283
R++ E LEKT L+ D T L + + +L K E++LQAA +
Sbjct: 1034 E---RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 284 QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYS---VTKERDDLKNKLKAEEEKGND 340
+++ E + +K+ E + + + D+E + S K++ DL +L+A + + D
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 341 LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLK 400
L + L+S E + LK L +++ K+ A QE ++ SQ VE L +L+
Sbjct: 1151 TLDS-TAAQQELRSKREQEVNILKKTLEEEA-KTHEAQIQEMR--QKHSQAVEELAEQLE 1206
Query: 401 DMKAIEDDLMKTEDEYETLERRYANE--------------RDKAQFLSKEL-------EH 439
K ++ +L K + E ANE R K + +EL E
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 440 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHL 499
V+ ELA + E + L L + ++KS L+++ AL+ ++ + T++L+
Sbjct: 1267 VRTELADKVTKLQVELDNVTGL---LSQSDSKSSKLTKDFSALESQLQD---TQELLQEE 1320
Query: 500 QGDHSVLQKKLNQQENRNRDLGREIE 525
L KL Q E+ ++E
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLE 1346
Score = 102 bits (254), Expect = 2e-21
Identities = 119/504 (23%), Positives = 222/504 (44%), Gaps = 56/504 (11%)
Query: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTK-LALAEARVQEEEQKAT--RLEKELQTQTTK 61
E++ ++A+ +R + + A+E TK L+LA A + EQKA RL K+ +T+
Sbjct: 1452 EEKTISAKYAEERDRAE---AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED 1508
Query: 62 FHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 121
+D + + + R L+Q++ + Q++EL E+ELQ ++ +
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL----------EDELQATEDAKLRL 1558
Query: 122 EYGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
E + A+ E +L+ R E K ++L++ Q R++ LE E Q +KL
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVR---QVREMEAELEDERKQRSMAVAARKKL 1615
Query: 181 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQEL-------ESLKVRIKELE 233
+ LE D+ NK++ E L K + K +EL E + + KE E
Sbjct: 1616 EMDLKDLEAHIDSANKNRDEAIK---QLRKLQAQMKDCMRELDDTRASREEILAQAKENE 1672
Query: 234 AIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVT 293
+E L+E+L + ER +++++ + K A + + + ++
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIA 1732
Query: 294 TVTEKLIEETKRALKSKTD-VEEKMYSVTKERDDLKNKLKAE------EEKGNDLLSRVN 346
+ E+L EE + T+ + +++ + D + L E E L R N
Sbjct: 1733 QLEEELEEE-----QGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 347 M-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKE---LSQEVERLKLKLKDM 402
LK +LQ +E K K + K Q +N+ KE ++V R + KLKD+
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847
Query: 403 KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLF 462
L++ +DE E +Y ++ DKA S L+ +K +L + + + + + L
Sbjct: 1848 ------LLQVDDERRNAE-QYKDQADKA---STRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Query: 463 KRLQEEEAKSGHLSREVDALKEKI 486
+ L++ + ++REV +LK K+
Sbjct: 1898 RELEDATETADAMNREVSSLKNKL 1921
Score = 99.4 bits (246), Expect = 1e-20
Identities = 115/562 (20%), Positives = 241/562 (42%), Gaps = 69/562 (12%)
Query: 19 KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDS 78
K +++ +E K E E K T+L+ EL D + L+ DS
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL-----------DNVTGLLSQSDS 1294
Query: 79 QNRQLQQKLAALSRQIDE----LEETNR-------SLRKAEEELQDIKEKISKGEYGNAG 127
++ +L + +AL Q+ + L+E NR L++ E+E +E++ + E
Sbjct: 1295 KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN 1354
Query: 128 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 187
+ ++ L +V DM+ K E+ + E ++ ++L+ KD + ++ +++ A
Sbjct: 1355 LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ------KDLEGLSQRHEEKVAAY 1408
Query: 188 EKLEDAFNKSKQECYSL----------KCNLEKERMTTKQLSQELESL------------ 225
+KLE + +QE L CNLEK++ QL E +++
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 226 -KVRIKELEAIE-SRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS 283
+ R KE +A+ +R + K +L +L +++ + + + K+ +L+ +
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR 1528
Query: 284 QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD-DLKNKLKAEEEKGNDLL 342
L+ + ++ T E+L +E + +K +E + ++ + + DL+ + + EEK L+
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLV 1588
Query: 343 SRVNMLKNRLQSLEAIEKDF---LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL 399
+V ++ L+ E ++ + KL D + N E +++ +L+ ++
Sbjct: 1589 RQVREMEAELED-ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 400 KD-MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHE 458
KD M+ ++D E E L + NE+ K + + E+ ++ ELA + A++
Sbjct: 1648 KDCMRELDDTRASRE---EILAQAKENEK-KLKSMEAEMIQLQEELAAAERAKRQAQQER 1703
Query: 459 QWLFKRLQEEEAKSG-------HLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLN 511
L + K L + L+E++ E +LI ++ ++N
Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQIN 1763
Query: 512 QQENRNRDLGREIENLTKELER 533
N R ++ EN ++LER
Sbjct: 1764 TDLNLERSHAQKNENARQQLER 1785
Score = 95.9 bits (237), Expect = 1e-19
Identities = 129/582 (22%), Positives = 248/582 (42%), Gaps = 75/582 (12%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
D AQ L+ ++ QE+ K + EA++QE QK ++ +EL Q +
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
+ + + +++ +L ++ L + ++ +K E +LQ+++ K ++GE
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVL---LQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 124 GNAGIMAEVEELRKRVLDMEG-------KDEELIK----MEEQCRDLNKRLERE-----T 167
+ +V +L+ + ++ G K +L K +E Q +D + L+ E +
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Query: 168 LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECY--------------SLKCNLEKERM 213
L +K ++E EK S R E+ E N KQ S+ C LE
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC-LETAEE 1385
Query: 214 TTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKK 273
++L ++LE L R +E A +LEKT+ L+++L L ++ +D ++ + L+K
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL----LVDLDHQRQSACNLEK 1441
Query: 274 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 333
+ K QL E+ T++ K EE RA + E K S+ + ++ + KA
Sbjct: 1442 KQKKF----DQLLAEEK---TISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ-KA 1493
Query: 334 EEEKGN--------DLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI 385
E E+ N DL+S + + + LE K L Q + T L + +++
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEK-----SKRALEQQVEEMKTQLEELEDEL 1548
Query: 386 KELSQEVERLKLKLKDMKA-IEDDLMKTEDEYE-----------TLERRYANERDKAQFL 433
+ RL++ L+ MKA E DL +++ E +E +ER +
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMA 1608
Query: 434 SKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMA-- 491
+ ++M+L + + + K+L++ +A+ RE+D + E +A
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA 1668
Query: 492 --TEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
E + ++ + LQ++L E R +E + L E+
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Score = 83.6 bits (205), Expect = 8e-16
Identities = 101/457 (22%), Positives = 201/457 (43%), Gaps = 51/457 (11%)
Query: 126 AGIMAEVEELRK-RVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRI 184
AG++A +EE R ++ D+ +I + CR L R+ + +L K+ +R
Sbjct: 765 AGVLAHLEEERDLKITDV------IIGFQACCRGY---LARKAFAKRQQQLTAMKVLQRN 815
Query: 185 MA-------------LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE 231
A K++ S+QE + E ++ KQL+ E R+ E
Sbjct: 816 CAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAEN-----RLTE 870
Query: 232 LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNK 291
+E ++S+L + L+E L L + R ++ K ++ E+ ++++ E+ +
Sbjct: 871 METLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEER 930
Query: 292 VTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNR 351
+ L E K+ ++ ++EE++ R L+ + E K L +L+++
Sbjct: 931 C----QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986
Query: 352 LQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 411
L A EK L++++ + TT L +E K K L++ + + + D+ E+ L +
Sbjct: 987 NCKL-AKEKKLLEDRI----AEFTTNLTEEEEKSKSLAKLKNKHEAMITDL---EERLRR 1038
Query: 412 TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAK 471
E + + LE+ + LS ++ ++ ++A+ K+ + Q R++EE A+
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098
Query: 472 SGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
+++ L+ +I E LQ D + N+ E + RDLG E+E L EL
Sbjct: 1099 KNMALKKIRELESQISE----------LQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 532 ERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 568
E S + + L +R + + K ++ EA +E
Sbjct: 1149 EDTLD-STAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Score = 73.6 bits (179), Expect = 8e-13
Identities = 71/353 (20%), Positives = 155/353 (43%), Gaps = 29/353 (8%)
Query: 18 QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQD-----QDTIMAK 72
+K ++L +E +L + R Q A R + E+ + + H D +D + +
Sbjct: 1582 EKKKQLVRQVREMEAELE--DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 73 LTNEDSQN----RQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGI 128
L +Q R+L A+ + + +E + L+ E E+ ++E+++ E
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 129 MAEVEELRKRVLDMEGKD----EELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRI 184
E +EL + + GK EE ++E + L + LE E + +L ++L K
Sbjct: 1700 QQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE---QGNTELINDRLKKAN 1756
Query: 185 MALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEA-IESRLEKTE 243
+ ++++ N + +K +QL ++ + LKV+++E+E ++S+ + +
Sbjct: 1757 LQIDQINTDLNLERSHA-------QKNENARQQLERQNKELKVKLQEMEGTVKSKYKASI 1809
Query: 244 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTV---TEKLI 300
L+ + +L+ ER+ +++++TE KL+ Q+ E+ +K
Sbjct: 1810 TALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS 1869
Query: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ 353
K+ + + EE+ R L+ +L+ E + + V+ LKN+L+
Sbjct: 1870 TRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 70.9 bits (172), Expect = 5e-12
Identities = 72/347 (20%), Positives = 153/347 (44%), Gaps = 27/347 (7%)
Query: 2 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQ---EEEQKATRLEKELQTQ 58
+V + + + A+L +R++ K+ L EA + + +A + ++LQ Q
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 59 TTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEE----TNRSLRKAEEELQDI 114
++ D A +Q ++ ++KL ++ ++ +L+E R+ R+A++E ++
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
Query: 115 KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ----S 170
++I+ A + E L R+ +E EEL + + +N RL++ LQ +
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLE---EELEEEQGNTELINDRLKKANLQIDQIN 1763
Query: 171 KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT-----KQLSQELESL 225
D LE K A ++LE + K + ++ ++ + + +++Q E L
Sbjct: 1764 TDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQL 1823
Query: 226 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 285
KE +A ++ +TE LK+ L + VD+ + +E+ K DK QL
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQ--------VDDERRNAEQYKDQADKASTRLKQL 1875
Query: 286 QVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 332
+ + + ++ ++ + D E ++ +E LKNKL+
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 110 bits (274), Expect = 8e-24
Identities = 107/545 (19%), Positives = 258/545 (47%), Gaps = 69/545 (12%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ +F + ++ +L +++ ++L++K+ L ++ ++L+ ++
Sbjct: 845 KSAETEKEMANMKEEFEKTKE----ELAKTEAKRKELEEKMVTLMQEKNDLQ---LQVQA 897
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 161
+ L D +E+ + + A+++E+ +R D E + EL K+E++C +L K
Sbjct: 898 EADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 957
Query: 162 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 207
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 958 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME 1017
Query: 208 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 264
+K TK +L Q+++ L+ +++ + + LE+ + L+ DL + T+ +++
Sbjct: 1018 EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDK 1077
Query: 265 KTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 314
+ ++EKLKK E ++ QA + QLQ + ++ E+L EE + S+ E
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 315 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS--- 371
++ +++E +++ +L EE G +++ M K R + + +D ++ L ++
Sbjct: 1138 KQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAA 1194
Query: 372 ------GKSTTALHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETLER 421
S L ++ + ++ + Q++E+ LK+++ D+ + + + K + +E + R
Sbjct: 1195 ALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCR 1254
Query: 422 RYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR---- 477
++ + + +E + + EL+ K TE+ ++L E++A LSR
Sbjct: 1255 TLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGE---FSRQLDEKDAMVSQLSRGKQA 1311
Query: 478 ---EVDALKEKIHEYMATEDLICH----LQGDHSVLQKKLNQQENRNRDLGREIENLTKE 530
+++ LK ++ E + + H + D +L+++ +++ +L R + E
Sbjct: 1312 FTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSE 1371
Query: 531 LERYR 535
+ ++R
Sbjct: 1372 VAQWR 1376
Score = 94.4 bits (233), Expect = 4e-19
Identities = 130/680 (19%), Positives = 283/680 (41%), Gaps = 128/680 (18%)
Query: 4 DEQQRLTAQLTLQRQKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKEL 55
+EQQRL +L+ Q+ ++ E +++ K A+ +A Q+ E+ +LE+E
Sbjct: 1268 EEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEET 1327
Query: 56 QTQTTKFH------QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI--------------- 94
+ ++T H D D + + E +LQ+ ++ + ++
Sbjct: 1328 KAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRT 1387
Query: 95 DELEETNRSLRK----AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI 150
+ELEE + L + AEE ++ + K + E + EVE+L ++D+E + I
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDL---MIDVERSNAACI 1444
Query: 151 KMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC 206
++++ R+ +K L + ++ + E+E K +L K+++A+ +S +LK
Sbjct: 1445 ALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKR 1504
Query: 207 ---NLEKE------------------RMTTKQLSQELESLKVRIKELEA----------- 234
NL++E KQL E L+ ++E EA
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILR 1564
Query: 235 -------IESRLEKTEFTLKEDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQA 280
++S +++ E+L +LK + V+ + T+ +++ D K++
Sbjct: 1565 IQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEG 1624
Query: 281 ASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGND 340
++++++ N + + + D + + + +DDLK +L E + N
Sbjct: 1625 DLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANL 1684
Query: 341 LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLK 396
+ + V L+ L+ E K + L D+ + LH +N + K+L ++ +++
Sbjct: 1685 MQAEVEELRASLERTERGRKMAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQIQ 1742
Query: 397 LKLKDM------------KAIED------DLMKTEDEYETLERRYANER----------D 428
+++D+ KAI D +L K +D LER N D
Sbjct: 1743 GEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLD 1802
Query: 429 KAQFLS-----KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALK 483
+A+ L+ K+++ ++ + + + ++E H K L++ E + L+ + + +
Sbjct: 1803 EAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDR 1862
Query: 484 EKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRP 543
+ I + +DL+ LQ +++ + E ++ + L ELE + +
Sbjct: 1863 KNI---LRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAES 1919
Query: 544 SLNGRRISDPQVFSKEVQTE 563
+N R+ +V +K + E
Sbjct: 1920 QVNKLRVKSREVHTKVISEE 1939
Score = 90.1 bits (222), Expect = 8e-18
Identities = 129/613 (21%), Positives = 264/613 (43%), Gaps = 76/613 (12%)
Query: 1 MVVDEQQRLTAQLTLQ---------RQKIQELTTNAKETHTKLALAEARVQEEEQ---KA 48
MV Q++ QL +Q ++ +L + K+ R ++EE+ +
Sbjct: 881 MVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAEL 940
Query: 49 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 108
T +++L+ + ++ +D D + L + + + K+ L+ ++ L+ET L K +
Sbjct: 941 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 109 EELQDIKEKI---SKGEYGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 164
+ LQ+ ++ + E + + + +L ++V D+EG E+ K+ C DL +R +
Sbjct: 1001 KALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKL---CMDL-ERAK 1056
Query: 165 RETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELES 224
R+ D KL E ++L + K + E +L+ +E E+ QL ++++
Sbjct: 1057 RKL--EGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE 1114
Query: 225 LKVRIKELE-------AIESRLEKTEFTLKEDLTKLK----------TLTVMFVDERKTM 267
L+ RI+ELE A ++ EK L +L ++ + + +R+
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 268 SEKLKK--TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD 325
+K+++ E LQ ++ + + +V E L E+ + K +E++ + E +
Sbjct: 1175 FQKMRRDLEESTLQHEATAAALRKKHADSVAE-LGEQIDSLQRVKQKLEKEKSELKMEIN 1233
Query: 326 DLK------NKLKAEEEKG----NDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST 375
DL +K KA EK D LS + + Q L E K +L+ +SG+ +
Sbjct: 1234 DLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRL-INELSAQKARLHTESGEFS 1292
Query: 376 TALHQENNKIKELS-------QEVERLKLKL----KDMKAIEDDLMKTEDEYETLERRYA 424
L +++ + +LS Q++E LK +L K + L + + L +Y
Sbjct: 1293 RQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYE 1352
Query: 425 NERDKAQFLSKELEHVKMELAKYKLAEKTET--------SHEQWLFKRLQEEEAKSGHLS 476
E++ L + + E+A+++ +T+ ++ L +RLQ+ E ++
Sbjct: 1353 EEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN 1412
Query: 477 REVDAL-KEKIHEYMATEDLICHLQGDHS---VLQKKLNQQENRNRDLGREIENLTKELE 532
+ +L K K EDL+ ++ ++ L KK + + ++ E ELE
Sbjct: 1413 SKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELE 1472
Query: 533 RYRHFSKSLRPSL 545
+ S+SL L
Sbjct: 1473 ASQKESRSLSTEL 1485
Score = 89.7 bits (221), Expect = 1e-17
Identities = 112/565 (19%), Positives = 239/565 (42%), Gaps = 64/565 (11%)
Query: 9 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 68
L L +++ +L ++ L LA+ + E +L ++L+ K +
Sbjct: 1038 LEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLK----KKEFEMSN 1093
Query: 69 IMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGI 128
+ K+ +E + QLQ+K+ L +I+EL EEE++ + +K E + +
Sbjct: 1094 LQGKIEDEQALAIQLQKKIKELQARIEEL----------EEEIEAERASRAKAEKQRSDL 1143
Query: 129 MAEVEELRKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQSKDFKLEV-EKLSKR 183
E+EE+ +R+ + G I+M E + + + + LE TLQ + + +K +
Sbjct: 1144 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADS 1203
Query: 184 IMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE 243
+ L + D+ + KQ+ LEKE+ +L E+ L ++ + ++ EK
Sbjct: 1204 VAELGEQIDSLQRVKQK-------LEKEK---SELKMEINDLASNMETVSKAKANFEKMC 1253
Query: 244 FTLKEDLTKLKT--------LTVMFVDERK--TMSEKLKKTEDKLQAASSQLQVEQNKVT 293
TL++ L+++KT + + + + T S + + D+ A SQL + T
Sbjct: 1254 RTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFT 1313
Query: 294 TVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL---LSRVN---- 346
E+L + + K+K+ + + S + D L+ + + E+E +L +S+ N
Sbjct: 1314 QQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVA 1373
Query: 347 --MLKNRLQSLEAIEK-DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMK 403
K +++ E+ + K KL Q + + N+K L + +RL+ +++D+
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433
Query: 404 -----------AIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 452
A++ + +++Y + + + KE + EL K K A +
Sbjct: 1434 IDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYE 1493
Query: 453 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH----LQGDHSVLQK 508
H + L + + + + L+ ++ + IHE + + H LQ +
Sbjct: 1494 ESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEA 1553
Query: 509 KLNQQENRNRDLGREIENLTKELER 533
L +E + + E+ + E++R
Sbjct: 1554 SLEHEEGKILRIQLELNQVKSEIDR 1578
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 110 bits (274), Expect = 8e-24
Identities = 105/401 (26%), Positives = 197/401 (49%), Gaps = 47/401 (11%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAE---ARVQEE--EQKATRLEKE--LQ 56
+E L A+L+ +++K +L ++A E +RV+E +Q+ R E+E L+
Sbjct: 1306 EEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLR 1365
Query: 57 TQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 116
+ + F + D + ++ ++ R+LQ++ L RQ++ELE ++ R+AE E+Q +++
Sbjct: 1366 AEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQ 1425
Query: 117 KISKGEYGNAGIMAEVEELRKRVLD---MEGKDEELIKM---EEQCRDLNKRLERETLQS 170
+++ E A +V +K VL + ++ L+++ EEQ R E ETL+
Sbjct: 1426 RLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRR 1485
Query: 171 KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
K LE ++ ++++ E ++ ++QE LK +LE+E + ++L E+ L+ R+
Sbjct: 1486 KLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLS 1545
Query: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 290
ELE S+ K L+E+ + KL+ LQ + +LQ E N
Sbjct: 1546 ELEFHNSKSSKELDFLREE------------------NHKLQLERQNLQLETRRLQSEIN 1587
Query: 291 KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKN 350
T T L T S T+ + +++S+ +E DDLK K DL ++ L+
Sbjct: 1588 MAATETRDLRNMT--VADSGTNHDSRLWSLERELDDLKRL-----SKDKDL--EIDELQK 1638
Query: 351 RLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQE 391
RL S+ A++++ +N L +S +H + +ELS E
Sbjct: 1639 RLGSV-AVKREQRENHLR----RSIVVIHPDTG--RELSPE 1672
Score = 85.9 bits (211), Expect = 2e-16
Identities = 122/559 (21%), Positives = 241/559 (43%), Gaps = 79/559 (14%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
++ QR Q +++ L K + A+AE ++ +E ++EK+ T+
Sbjct: 1075 EDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKE--VLKVEKDAATE----- 1127
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
++ + + +E ++ R Q++ L R+I LEE N + +E++++I K E
Sbjct: 1128 REVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKV-VVQEKVREIVRPDPKAE- 1185
Query: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKR 183
+EV LR +++ E K EEQ R LE L+ + ++EV++++K
Sbjct: 1186 ------SEVANLRLELVEQERKYRGA---EEQLRSYQSELE--ALRRRGPQVEVKEVTKE 1234
Query: 184 IMALE---KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240
++ + ++E + ++E +E+ + QL +E+++LK +++ E E
Sbjct: 1235 VIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQE 1294
Query: 241 KTEF-----------TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQ 289
+F +L+ L++ + V ER + E++ + E++L ++ V+Q
Sbjct: 1295 ILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERV-VQQ 1353
Query: 290 NKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK 349
V E + A DVE ++ D L+ +L+ + + +L ++ L+
Sbjct: 1354 EVVRYEEEPGLRAEASAFAESIDVE------LRQIDKLRAELRRLQRRRTELERQLEELE 1407
Query: 350 NRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDL 409
Q+ E++ Q + AL QE + +E +++ L+ +A E L
Sbjct: 1408 RERQARREAEREV------QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHAL 1461
Query: 410 MKT------------EDEYETLERRYANERDKAQFLSKEL--EHVKMELA---------K 446
++ E E ETL R+ A +KA+ K + E V++E K
Sbjct: 1462 LRLQLEEEQHRRQLLEGELETLRRKLA-ALEKAEVKEKVVLSESVQVEKGDTEQEIQRLK 1520
Query: 447 YKLAEKTETSHE-----QWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQG 501
L E++ + E L RL E E + S+E+D L+E+ H+ +LQ
Sbjct: 1521 SSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQ---NLQL 1577
Query: 502 DHSVLQKKLNQQENRNRDL 520
+ LQ ++N RDL
Sbjct: 1578 ETRRLQSEINMAATETRDL 1596
Score = 76.6 bits (187), Expect = 9e-14
Identities = 120/563 (21%), Positives = 250/563 (44%), Gaps = 102/563 (18%)
Query: 44 EEQKATRLEKE--------LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQID 95
EE +A R +K LQ + +++ K+T ++ Q +L A +Q+
Sbjct: 1015 EELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQ 1074
Query: 96 ELEETNRSLR-KAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEE 154
E + LR K EEEL +++K+ + E A MAE + K VL +E KD E
Sbjct: 1075 EDHQRQDQLREKQEEELSFLQDKLKRLEKERA--MAEGKITVKEVLKVE-KDAAT---ER 1128
Query: 155 QCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE----------KLEDAFN---KSKQEC 201
+ DL ++ E E +++ + E +L ++I ALE K+ + K++ E
Sbjct: 1129 EVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEV 1188
Query: 202 YSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFV 261
+L+ L ++ + ++L S + ELEA+ R + E +++TK
Sbjct: 1189 ANLRLELVEQERKYRGAEEQLRSYQ---SELEALRRRGPQVEV---KEVTK--------- 1233
Query: 262 DERKTMSEKLK-KTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSV 320
E +K KT+ +++ +L+ E+++++T+ L + D+E +Y +
Sbjct: 1234 -------EVIKYKTDPEMEKELQRLR----------EEIVDKTR--LIERCDLE--IYQL 1272
Query: 321 TKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQ 380
KE LK+ + K +++ + + Q+ E + L+ KL+++ K +
Sbjct: 1273 KKEIQALKDTKPQVQTK--EVVQEILQFQEDPQTKEEVAS--LRAKLSEEQKKQVDLERE 1328
Query: 381 ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHV 440
++ ++++++ E L ++K+ + ++ ++++ E+E A A+ + EL +
Sbjct: 1329 RASQEEQIARKEEELS-RVKE-RVVQQEVVRYEEE----PGLRAEASAFAESIDVELRQI 1382
Query: 441 KMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI----HEYMATEDLI 496
A+ + ++ T E+ L + L+ E REV L++++ E + +
Sbjct: 1383 DKLRAELRRLQRRRTELERQL-EELERERQARREAEREVQRLQQRLAALEQEEAEAREKV 1441
Query: 497 CHLQG-----------DHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 545
H Q +H++L+ +L ++++R + L E+E L ++L +L
Sbjct: 1442 THTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-----------AAL 1490
Query: 546 NGRRISDPQVFSKEVQTEAVDNE 568
+ + V S+ VQ E D E
Sbjct: 1491 EKAEVKEKVVLSESVQVEKGDTE 1513
Score = 75.1 bits (183), Expect = 3e-13
Identities = 129/632 (20%), Positives = 263/632 (41%), Gaps = 81/632 (12%)
Query: 15 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQ-----TTKFHQDQDTI 69
L R ++++ TN K H L A QE+ A RLEK LQ T + H +QD
Sbjct: 585 LLRTRVED--TNRKYEHLLQLLDLA--QEKVDVANRLEKSLQQSWELLATHENHLNQDDT 640
Query: 70 MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIM 129
+ + +R L K L+ EL+ L + E+ LQ K+ S
Sbjct: 641 VPE------SSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSS---------- 684
Query: 130 AEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK-RIMALE 188
++ D+E ++ E+ K+ ++ +L +++ER + K E + L+
Sbjct: 685 TLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQ 744
Query: 189 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKE 248
L + QE SL +E + K L E+ S + ++++ A + ++
Sbjct: 745 FLVSIPSYEPQETDSLS-QMETKLKNQKNLLDEIASREQEVQKICANSQQYQQA------ 797
Query: 249 DLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALK 308
V + + +EKL+ D SS + + T+ ++E + AL
Sbjct: 798 ------------VKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATK--VKEEEAALA 843
Query: 309 SKTDVEEKMYSVTKER-DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 367
+K ++Y++ ++R +L+ L ++ ++ + +NR S +E+ + K+
Sbjct: 844 AKFT---EVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDS--GVEEAW---KI 895
Query: 368 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT------EDEYETLER 421
++ + T Q N++K +E+ L+ + + +++K E+ ++ L+R
Sbjct: 896 RKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQR 955
Query: 422 RYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK---RLQEEEAKSG---HL 475
A E+ K Q L +ELE ++++L L ++T ++++ K R++ + A++ L
Sbjct: 956 TLAEEQHKNQLLQEELEALQLQLR--ALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQL 1013
Query: 476 SREVDALKE----KIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
E++AL+ + E + + + L + S Q+K+ ++E ++E ++L
Sbjct: 1014 REELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQL 1073
Query: 532 ERYRHFSKSLRPSLNGRRISDPQVFSKEVQTE-AVDNEPPDYKSLIPLERAVINGQLYEE 590
+ LR +S Q K ++ E A+ K ++ +E+ E
Sbjct: 1074 QEDHQRQDQLREK-QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT-----E 1127
Query: 591 SENQDEDPNDEGSVLSFKCSQSTPCPVNRKLW 622
E D E + SQ + RK+W
Sbjct: 1128 REVSDLTRQYEDEAAKARASQREKTELLRKIW 1159
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 109 bits (272), Expect = 1e-23
Identities = 146/642 (22%), Positives = 289/642 (45%), Gaps = 114/642 (17%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL-------- 55
+E QR QL ++K Q LT ++T L + R E E+K R + EL
Sbjct: 1419 EESQRALQQL---KKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ 1475
Query: 56 --QTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQD 113
+ Q K +++D ++A+ + Q + +A ++++ LE ELQD
Sbjct: 1476 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEA----------ELQD 1525
Query: 114 IKEKISKGEYGNAGIMAEVEELRKRVLDMEGK----DEEL------IKMEEQCRDLNKRL 163
I + SK E A + +++K++ D+E K +EEL I+M EQ + L +
Sbjct: 1526 ISSQESKDE-------ASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK-LRLEM 1577
Query: 164 ERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE 223
E E ++ K E+E E++E+A +++ ++ LE+E +++ +E
Sbjct: 1578 EMERMRQTHSK-EMESRD------EEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKR 1630
Query: 224 SLKVRIKEL-EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAAS 282
L+ ++ L + + R ++E L++DL + K L D + + K + A
Sbjct: 1631 ELEGKLATLSDQVNRRDFESEKRLRKDLKRTKAL---LADAQLMLDHLKNSAPSKREIAQ 1687
Query: 283 SQLQVEQNKVTTVT------------EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK 330
+ Q+E+++ T E L + K+KT +EE++ + +E+++++N+
Sbjct: 1688 LKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNR 1747
Query: 331 LKAEEEKGNDL--------------LSRVNMLKNRLQSLEAIEKDFLKNKLN-------- 368
L+ ++E N+L L+++N L+ +L+ EK L+ KL
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANK-EKQELQEKLQALQSQVEF 1806
Query: 369 -QDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEY-ETLERRYA-- 424
+ S + + ++ KI+EL +E + ++K ++++ L + ++ E ++R A
Sbjct: 1807 LEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAE 1866
Query: 425 -NERDKAQFLSKELEHVKMELAKY--KLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDA 481
E+++ + L ++L K E+ + K AE + HE L L+ EA + L ++
Sbjct: 1867 NREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE--LEMDLESLEAANQSLQADLKL 1924
Query: 482 LKEKIHEYMA----------TEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
++I + A EDLI LQ + QK+ N+ E + D+ E+E+ +
Sbjct: 1925 AFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEG-DSDVDSELEDRVDGV 1983
Query: 532 ERYRHFSKSLRPSL-----NGRRISDPQVFSKEVQTEAVDNE 568
+ + SK+ PS + S P + K + + D+E
Sbjct: 1984 KSW--LSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDE 2023
Score = 90.5 bits (223), Expect = 6e-18
Identities = 120/624 (19%), Positives = 267/624 (42%), Gaps = 109/624 (17%)
Query: 12 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT--- 68
++ L ++I+ ++ +KL AE E + RLE + T++ +++T
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGES 1307
Query: 69 -------IMAKLTNEDSQNRQLQQKLAALSRQID--ELEETNRSLRKAEEELQDIKEKIS 119
A+ + + ++LQ + AL +Q++ E+E L +A E ++ + +
Sbjct: 1308 ASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDA 1367
Query: 120 KGEYGNAGIMA-------------------EVEELRKRVLDMEGKDEELIKMEEQ--CRD 158
GE+ A EVE+ KR L+ D + E Q +
Sbjct: 1368 GGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQ 1427
Query: 159 LNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQ------------------- 199
L K+ +R T + +D KL +E R LEK + F+
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1487
Query: 200 ------ECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKL 253
E +SLK LE++ M +Q++ SL+ ++++ + ES+ E + +K+ L L
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDL 1547
Query: 254 KTL-------------TVMFVDE------------RKTMSEKLKKTEDKLQAASSQLQVE 288
+ T+ +++ R+T S++++ +++++ A Q +
Sbjct: 1548 EAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKK 1607
Query: 289 QNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKE---RD-DLKNKLKAEEEKGNDLLSR 344
++ E+ E+ ++ L+ K ++E K+ +++ + RD + + +L+ + ++ LL+
Sbjct: 1608 LKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLAD 1667
Query: 345 VNMLKNRLQSLEAIEKDF--LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDM 402
++ + L++ +++ LKN+L + A+ K + E+E L L++
Sbjct: 1668 AQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR----KAMEVEIEDLHLQI--- 1720
Query: 403 KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLF 462
DD+ K + E R E+++ Q +E + EL K A + S +
Sbjct: 1721 ----DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD---L 1773
Query: 463 KRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL-NQQENRNRDLG 521
++ + +A+ ++E L+EK+ + + + + S++ K L ++QE + R+L
Sbjct: 1774 AQINDLQAQLEEANKEKQELQEKLQALQSQVEFL-----EQSMVDKSLVSRQEAKIRELE 1828
Query: 522 REIENLTKELERYRHFSKSLRPSL 545
+E +++R + L+ ++
Sbjct: 1829 TRLEFERTQVKRLESLASRLKENM 1852
Score = 77.8 bits (190), Expect = 4e-14
Identities = 84/451 (18%), Positives = 200/451 (44%), Gaps = 53/451 (11%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTK-LALAEARVQEEEQKATRLEKELQTQTTK 61
+DEQ L + +++ ++TH+K + + V+E Q + K+++ Q +
Sbjct: 1558 LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 62 FHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE-ETNRSLRK-------------- 106
++D+ ++ + R+L+ KLA LS Q++ + E+ + LRK
Sbjct: 1618 EYEDKQKVLR-------EKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQL 1670
Query: 107 ----------AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 156
++ E+ +K ++ + E+ A + + + + D+ + +++ K +
Sbjct: 1671 MLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTAL 1730
Query: 157 RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA-FNKSKQECYSLKCNLEKERMTT 215
+ RL+RE + ++ E ++ +M K A ++ + L+ LE+
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEK 1790
Query: 216 KQLSQELESLKVRIKELEAI---ESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK 272
++L ++L++L+ +++ LE +S + + E ++E T+L+ V ++++ +LK
Sbjct: 1791 QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ-VKRLESLASRLK 1849
Query: 273 KTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 332
+ +KL Q +N+ ++L + + + ++ K ++++ +L+ L+
Sbjct: 1850 ENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLE 1909
Query: 333 AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKS----TTALHQENNKIK-- 386
+ E L + + + R+ L+A +D +++ N+D S T + NK++
Sbjct: 1910 SLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGD 1969
Query: 387 -----ELSQEVERLKLKLK----DMKAIEDD 408
EL V+ +K L KA DD
Sbjct: 1970 SDVDSELEDRVDGVKSWLSKNKGPSKAASDD 2000
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 109 bits (272), Expect = 1e-23
Identities = 105/545 (19%), Positives = 255/545 (46%), Gaps = 69/545 (12%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ T +F + +D +L +++ ++L++K+ L ++ ++L+ ++
Sbjct: 844 KSAETEKEMATMKEEFQKTKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQS 896
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 161
+ L D +E+ + + A+++E+ +R + E + EL K+E++C +L K
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD 956
Query: 162 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 207
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 957 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE 1016
Query: 208 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 264
+K + TK +L Q+++ L+ +++ + + LE+ + L+ DL + T+ +++
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDK 1076
Query: 265 KTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 314
+ + EKL+K E ++ QA QLQ + ++ E+L EE + S+ E
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 1136
Query: 315 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS--- 371
++ +++E +++ +L EE G ++V + K R + + +D + L ++
Sbjct: 1137 KQRSDLSRELEEISERL---EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVA 1193
Query: 372 ------GKSTTALHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETLER 421
S L ++ + ++ + Q++E+ LK++ D+ + + + K + E + R
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253
Query: 422 RYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR---- 477
++ + + +E + + +L + +TE ++L E++A LSR
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYS---RQLDEKDALVSQLSRSKQA 1310
Query: 478 ---EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLTKE 530
+++ LK ++ E ++ + H + D +L+++ +++ +L R + E
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1370
Query: 531 LERYR 535
+ ++R
Sbjct: 1371 VAQWR 1375
Score = 102 bits (254), Expect = 2e-21
Identities = 123/595 (20%), Positives = 250/595 (42%), Gaps = 83/595 (13%)
Query: 18 QKIQELTTNAKETHTKLALAEARVQEEEQ---KATRLEKELQTQTTKFHQDQDTIMAKLT 74
++ ++L N + K+ R +EEE+ + T +++L+ + ++ +D D + L
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965
Query: 75 NEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI---SKGEYGNAGIMAE 131
+ + + K+ L+ ++ L+ET L K ++ LQ+ ++ + E I+ +
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025
Query: 132 VE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKL 190
+ +L ++V D+EG E+ K+ ++LE D KL E ++L
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE------GDLKLAQESTMDMENDKQQL 1079
Query: 191 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI--------------------- 229
++ K + E +L +E E+ QL ++++ L+ RI
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQR 1139
Query: 230 ----KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE---------------- 269
+ELE I RLE+ + K F R+ + E
Sbjct: 1140 SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKH 1199
Query: 270 -----KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 324
+L + D LQ +L+ E++++ T+ L + K+K ++E+ S+ +
Sbjct: 1200 ADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQV 1259
Query: 325 DDLKNKLKAEEEKGNDLLSRVNMLKNRL--QSLEAIEKDFLKNKLNQDSGKSTTALHQEN 382
+LK K + ++ NDL ++ L+ S + EKD L ++L++ ST
Sbjct: 1260 SELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST------- 1312
Query: 383 NKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKM 442
+I+EL ++E + K A+ L + + + L +Y E++ L + L
Sbjct: 1313 QQIEELKHQLEE---ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS 1369
Query: 443 ELAKYKLAEKTET--------SHEQWLFKRLQEEEAKSGHLSREVDAL-KEKIHEYMATE 493
E+A+++ +T+ ++ L +RLQE E ++ + +L K K E
Sbjct: 1370 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVE 1429
Query: 494 DLICHLQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERYRHFSKSLRPSL 545
DL+ ++ ++ +Q N ++ L ++ E ELE + S+SL L
Sbjct: 1430 DLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Score = 91.7 bits (226), Expect = 3e-18
Identities = 138/606 (22%), Positives = 255/606 (42%), Gaps = 95/606 (15%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
+EQQRL LT QR ++Q T A E +L E++ ++L + Q T
Sbjct: 1267 EEQQRLINDLTAQRARLQ---TEAGEYSRQL-------DEKDALVSQLSRSKQAST---- 1312
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS---- 119
Q + + +L E L L + D L E ++ + ELQ K +
Sbjct: 1313 QQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1372
Query: 120 --KGEYGNAGIMA--EVEELRKRVLD-MEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 174
+ +Y I E+EE +K++ ++ +E + + +C L K +R + +D
Sbjct: 1373 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1432
Query: 175 LEVEKLSKRIMALEKLEDAFNKS----KQECYSLKCNLEKERMTTKQLSQELESLK-VRI 229
L+VE+ + AL+K + F+K KQ+ + LE + ++ LS EL +K V
Sbjct: 1433 LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYE 1492
Query: 230 KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMS--EKLKKTEDK--------LQ 279
+ L+ +E+ L + L+++++ LT + K + EK+KK ++ L+
Sbjct: 1493 ESLDQLET-LRRENKNLQQEIS---DLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALE 1548
Query: 280 AASSQLQVEQNKVTTVTEKL----IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE 335
A + L+ E+ K+ + +L E ++ + ++++ + T+ + +++ L AE
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608
Query: 336 EKGNDLL-------SRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQEN-----N 383
ND L +N ++ +L + + L+N N T LH ++
Sbjct: 1609 RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE 1668
Query: 384 KIKE-----------LSQEVERLKLKL----KDMKAIEDDLMKTEDEYETLERRYAN--- 425
+KE L E+E L L + K E +L+ + + L + +
Sbjct: 1669 DLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN 1728
Query: 426 -----ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 480
E D +Q L E+E V E + K + + + L++E+ S HL R
Sbjct: 1729 TKKKLENDVSQ-LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1787
Query: 481 ALKEKI----HEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRH 536
L++ + H E L L+G +K++ + E R R+L E+EN E +R
Sbjct: 1788 NLEQTVKDLQHRLDEAEQLA--LKGG----KKQIQKLEARVRELEGEVEN---EQKRNAE 1838
Query: 537 FSKSLR 542
K LR
Sbjct: 1839 AVKGLR 1844
Score = 84.0 bits (206), Expect = 6e-16
Identities = 121/573 (21%), Positives = 245/573 (42%), Gaps = 88/573 (15%)
Query: 9 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 68
L L +++ +L ++ L LA+ + E +L+++L+ + +
Sbjct: 1037 LEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEI----SN 1092
Query: 69 IMAKLTNEDSQNRQLQQKLAALSRQIDEL----EETNRSLRKAEEELQDIKEKISKGEYG 124
+++K+ +E + QLQ+K+ L +I+EL E S KAE++ D+
Sbjct: 1093 LISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR-------- 1144
Query: 125 NAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
E+EE+ +R+ + G + K E + + L + LE TLQ + + K
Sbjct: 1145 ------ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK 1198
Query: 181 SKRIMA-LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRL 239
MA L + D + KQ+ LEKE+ +L E + L + + + L
Sbjct: 1199 HADSMAELGEQIDNLQRVKQK-------LEKEK---SELKMETDDLSSNAEAISKAKGNL 1248
Query: 240 EKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL 299
EK +L++ V E KT E+ ++ + L A ++LQ E + + ++
Sbjct: 1249 EKMCRSLEDQ-----------VSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDE- 1296
Query: 300 IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EA 357
K AL S+ + + T++ ++LK++L+ E + N L + ++ L +
Sbjct: 1297 ----KDALVSQ--LSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQY 1350
Query: 358 IEKDFLKNKLNQDSGKSTTALHQENNKIK----ELSQEVERLKLKLKDMKAIEDDLMKTE 413
E+ K +L + K+ + + Q K + + ++E+E K KL L + E
Sbjct: 1351 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR------LQEAE 1404
Query: 414 DEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSG 473
+ E + + A+ Q L E+E + +++ + A ++ K L E + K
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464
Query: 474 HLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQE---NRNRDLGREIENLTKE 530
E++A +++ + L L +V ++ L+Q E N++L +EI +LT++
Sbjct: 1465 ETQAELEASQKE------SRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQ 1518
Query: 531 LERYRHFSKSLRPSLNGRRISDPQVFSKEVQTE 563
+ G++I + + K+V+ E
Sbjct: 1519 IAE------------GGKQIHELEKIKKQVEQE 1539
Score = 63.5 bits (153), Expect = 8e-10
Identities = 88/445 (19%), Positives = 193/445 (43%), Gaps = 45/445 (10%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 62
+D+ + L + +Q+I +LT E ++ E ++ EQ+ ++ L+
Sbjct: 1495 LDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASL 1554
Query: 63 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE 122
++ I+ + ++ +K+A +ID+L+ + + + + D
Sbjct: 1555 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD--------- 1605
Query: 123 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQS--------KDFK 174
A I + + LR + MEG +L +ME Q N RL E+L++ K+ +
Sbjct: 1606 ---AEIRSRNDALRVK-KKMEG---DLNEMEIQLNHAN-RLAAESLRNYRNTQGILKETQ 1657
Query: 175 LEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
L ++ + L++ +E N + E L LE+ + K QEL R++
Sbjct: 1658 LHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQ 1717
Query: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 290
L + L T+ L+ D+++L++ + E + EK KK + +L+ EQ+
Sbjct: 1718 LLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQD 1777
Query: 291 KVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
+ +K +E+T + L+ + D E++ LK +++ L +RV L
Sbjct: 1778 TSAHLERMKKNLEQTVKDLQHRLDEAEQL------------ALKGGKKQIQKLEARVREL 1825
Query: 349 KNRLQSLEAIEKDFLKN-KLNQDSGKSTTALHQENNK-IKELSQEVERLKLKLKDMKAIE 406
+ +++ + + +K + ++ K T +E+ K + L V++L+ K+K K
Sbjct: 1826 EGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQA 1885
Query: 407 DDLMKTEDEYETLERRYANERDKAQ 431
++ + + + R+ +E ++A+
Sbjct: 1886 EEAEEQSNANLSKFRKLQHELEEAE 1910
Score = 58.5 bits (140), Expect = 3e-08
Identities = 61/268 (22%), Positives = 118/268 (44%), Gaps = 23/268 (8%)
Query: 83 LQQKLAALSRQIDEL----EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKR 138
++++ L +I+EL E+T RS + AE+EL D E++ N ++ ++L
Sbjct: 1677 VERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLEND 1736
Query: 139 VLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSK 198
V ++ + EE+I+ + K+ D + E+L K LE +
Sbjct: 1737 VSQLQSEVEEVIQESRNAEEKAKK------AITDAAMMAEELKKEQDTSAHLERMKKNLE 1790
Query: 199 QECYSLKCNL-EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTK----L 253
Q L+ L E E++ K ++++ L+ R++ELE +K + L K +
Sbjct: 1791 QTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRV 1850
Query: 254 KTLTVMFVDERKTMSEKLKKTEDKLQA-------ASSQLQVEQNKVTTVTEKLIEETKRA 306
K LT ++RK + +L+ DKLQA + + + + N + KL E + A
Sbjct: 1851 KELTYQTEEDRKNVL-RLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEA 1909
Query: 307 LKSKTDVEEKMYSVTKERDDLKNKLKAE 334
+ E ++ + + ++ K+ AE
Sbjct: 1910 EERADIAESQVNKLRVKSREVHTKISAE 1937
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 108 bits (271), Expect = 2e-23
Identities = 138/580 (23%), Positives = 247/580 (42%), Gaps = 89/580 (15%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 62
VD L +++ ++K++ T+ + T L +E QK K L T T K
Sbjct: 496 VDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI---KALYTATEKL 552
Query: 63 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE 122
++ +++ +KL + + +N + ++ +LE S ++A EEL K SKG
Sbjct: 553 SKENESLKSKLEHANKENSDV------IALWKSKLETAIASHQQAMEEL---KVSFSKGL 603
Query: 123 YGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLS 181
AE++ ++ K LD + + E L ++ R + + E E L++K K+ EK +
Sbjct: 604 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK-EMEALRAKLMKVIKEKEN 662
Query: 182 KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK 241
KL+ A ++ E L++ + K+L + K ++ S+L+
Sbjct: 663 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 722
Query: 242 TEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL-- 299
TE L DL L+ + E K + ++L+ E +++ + E +K +++T +L
Sbjct: 723 TEEKLL-DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG 781
Query: 300 ---------------------IEETKRALKSK-TDVEEKMYSVTKERDDLKNKLKAEEEK 337
+E+ + LK K + E+ SV + + NKL +EE+
Sbjct: 782 RELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ 841
Query: 338 GNDLLSRVNMLKNRLQSLEA--IEKD-------FLKNKLNQD-------SGKSTTALHQE 381
N L S + L+ L +EA EKD K KL D SG +++ L +
Sbjct: 842 FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 901
Query: 382 NNKIKELSQEVERLKLKLKD--------MKAIEDDLMKTEDEYETLERRYANERDKAQFL 433
N++++ ++VE L+LKL K+IED +K E + +++ E+
Sbjct: 902 NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK------ 955
Query: 434 SKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATE 493
KELE +L K K ETSH Q + + E A S ++ + L+ + TE
Sbjct: 956 -KELERKLSDLEK-----KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE 1009
Query: 494 DLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 533
D KL N L +E+E L K+ ++
Sbjct: 1010 D--------------KLKGAREENSGLLQELEELRKQADK 1035
Score = 91.3 bits (225), Expect = 4e-18
Identities = 121/551 (21%), Positives = 242/551 (43%), Gaps = 58/551 (10%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKL----ALAEARVQEEEQKATRLEKELQTQ 58
V E + L A+ Q + I T+ K T KL AL +A E + + +L ++L+
Sbjct: 696 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS-SEGKSEMKKLRQQLEAA 754
Query: 59 TTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI 118
+ + A+ + S R+LQ + L+ + L E ++ E+ELQ +KEK
Sbjct: 755 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 814
Query: 119 SKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE 178
++ + ++E V + K+E+ + DL K E F+ + E
Sbjct: 815 AEASEEAVSVQRSMQET---VNKLHQKEEQFNMLSS---DLEKLRENLADMEAKFREKDE 868
Query: 179 KLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESR 238
+ + I A EKLE+ + + L K + +++E L++++ + S
Sbjct: 869 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 928
Query: 239 LEKT--EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVT 296
L+K+ + T+K + ++ + +E+K + KL E K++ + +Q Q + + T
Sbjct: 929 LQKSIEDMTVKAEQSQQEAAK-KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT 987
Query: 297 EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNR----- 351
+ +KT EE + ++ K D ++KLK E+ + LL + L+ +
Sbjct: 988 SE----------TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAK 1037
Query: 352 --------LQSLEAIEKDFLKNKLNQDSGKSTTA-LHQENNKIKELS-QEVERLKLKLKD 401
+Q +E + K+ + + + K T A L E + +KE + + VE L K K+
Sbjct: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN-KSKE 1096
Query: 402 MKAIEDDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQW 460
+ +E+ M+ E ETL++ A + + L +E + EL + + TSH+
Sbjct: 1097 LLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR---SRDEVTSHQ-- 1151
Query: 461 LFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDL 520
+L+EE + L+ ++ +K++ +++ D + + LQK ++ +
Sbjct: 1152 ---KLEEERSV---LNNQLLEMKKRESKFIKDAD------EEKASLQKSISITSALLTEK 1199
Query: 521 GREIENLTKEL 531
E+E L E+
Sbjct: 1200 DAELEKLRNEV 1210
Score = 71.2 bits (173), Expect = 4e-12
Identities = 101/490 (20%), Positives = 205/490 (41%), Gaps = 44/490 (8%)
Query: 72 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN----AG 127
K++ + L++K + + + E + + KA + +I+++++ G+
Sbjct: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE 405
Query: 128 IMAEVEELRKRVLDMEGKDEELI-KMEEQCR---DLNKRLERETLQSKDFKLEVEKLSKR 183
+ A++++LR V + + EL+ ++EE+ R DL R+E E++ D ++ R
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
Query: 184 IMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE 243
IM LEK QE L+ LE + + +++ ++E+ +++ +LE T
Sbjct: 466 IMELEK---DLALRVQEVAELRRRLESNKP-----AGDVDMSLSLLQEISSLQEKLEVTR 517
Query: 244 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEET 303
+ ++T LK E E+ Q L K++ E L +
Sbjct: 518 TDHQREITSLK--------------EHFGAREETHQKEIKALYTATEKLSKENESLKSKL 563
Query: 304 KRALKSKTDV----EEKMYSVTKERDDLKNKLKAEEEKG-NDLLSRVNMLKNRLQSLEAI 358
+ A K +DV + K+ + +LK KG + LK +++ +
Sbjct: 564 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 623
Query: 359 EKDFLKNKLNQ-DSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYE 417
+ ++N NQ DS ++ A E + K + +K K ++AI L K ED++
Sbjct: 624 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKV----IKEKENSLEAIRSKLDKAEDQHL 679
Query: 418 TLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR 477
N+ +A+ KELE ++ + + TS + ++L + +A S
Sbjct: 680 VEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSE 739
Query: 478 EVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ--QENRNRDLGREIENLTKELERYR 535
+K+ + A E I HL+ + + K + +E + R+L ++ NL + L
Sbjct: 740 GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL--KLTNLQENLSEVS 797
Query: 536 HFSKSLRPSL 545
++L L
Sbjct: 798 QVKETLEKEL 807
Score = 62.8 bits (151), Expect = 1e-09
Identities = 94/418 (22%), Positives = 180/418 (43%), Gaps = 90/418 (21%)
Query: 10 TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTI 69
++QLT +++ + +E KL A + A+ L+K ++ T K Q Q
Sbjct: 895 SSQLTKMNDELRLKERDVEELQLKLTKAN-------ENASFLQKSIEDMTVKAEQSQQEA 947
Query: 70 MAKLTNEDSQNRQLQQKLAALSRQID-------ELEE-----TNRSLRKAEEELQ----- 112
K + + ++L++KL+ L ++++ EL+ T+ + K EE LQ
Sbjct: 948 AKK---HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKT 1004
Query: 113 --DIKEKISKGEYGNAGIMAEVEELRKR---------------VLDMEGKDE-ELIKMEE 154
D ++K+ N+G++ E+EELRK+ +++ K++ E + E
Sbjct: 1005 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLE 1064
Query: 155 QCRDLNKRLERE--TLQSKDFKLEVEKL--SKRIMALE--KLED-----------AFNKS 197
+ N +L+ E TL+ + K VE+L SK ++ +E K+E+ A KS
Sbjct: 1065 DTKQTNAKLQNELDTLKENNLK-NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1123
Query: 198 KQECYSLKCNLE--------KERMTTKQ-LSQELESLKVRIKELEAIESRLEKTEFTLKE 248
+Q + N++ ++ +T+ Q L +E L ++ E++ ES+ K K
Sbjct: 1124 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA 1183
Query: 249 DLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTV------------- 295
L K ++T + E+ EKL+ L+ ++ + + V T+
Sbjct: 1184 SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN 1243
Query: 296 TEKLIEETKRALKSK-----TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
E ++E KR L S T +E + + D L + + + K DL +V M+
Sbjct: 1244 LELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1301
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 108 bits (271), Expect = 2e-23
Identities = 138/580 (23%), Positives = 247/580 (42%), Gaps = 89/580 (15%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 62
VD L +++ ++K++ T+ + T L +E QK K L T T K
Sbjct: 531 VDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI---KALYTATEKL 587
Query: 63 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE 122
++ +++ +KL + + +N + ++ +LE S ++A EEL K SKG
Sbjct: 588 SKENESLKSKLEHANKENSDV------IALWKSKLETAIASHQQAMEEL---KVSFSKGL 638
Query: 123 YGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLS 181
AE++ ++ K LD + + E L ++ R + + E E L++K K+ EK +
Sbjct: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK-EMEALRAKLMKVIKEKEN 697
Query: 182 KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK 241
KL+ A ++ E L++ + K+L + K ++ S+L+
Sbjct: 698 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 757
Query: 242 TEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL-- 299
TE L DL L+ + E K + ++L+ E +++ + E +K +++T +L
Sbjct: 758 TEEKLL-DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG 816
Query: 300 ---------------------IEETKRALKSK-TDVEEKMYSVTKERDDLKNKLKAEEEK 337
+E+ + LK K + E+ SV + + NKL +EE+
Sbjct: 817 RELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ 876
Query: 338 GNDLLSRVNMLKNRLQSLEA--IEKD-------FLKNKLNQD-------SGKSTTALHQE 381
N L S + L+ L +EA EKD K KL D SG +++ L +
Sbjct: 877 FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 936
Query: 382 NNKIKELSQEVERLKLKLKD--------MKAIEDDLMKTEDEYETLERRYANERDKAQFL 433
N++++ ++VE L+LKL K+IED +K E + +++ E+
Sbjct: 937 NDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK------ 990
Query: 434 SKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATE 493
KELE +L K K ETSH Q + + E A S ++ + L+ + TE
Sbjct: 991 -KELERKLSDLEK-----KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE 1044
Query: 494 DLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 533
D KL N L +E+E L K+ ++
Sbjct: 1045 D--------------KLKGAREENSGLLQELEELRKQADK 1070
Score = 91.3 bits (225), Expect = 4e-18
Identities = 151/652 (23%), Positives = 278/652 (42%), Gaps = 106/652 (16%)
Query: 7 QRLTAQLTLQRQKIQELTTNAKETHTKLALA----EARVQEEEQK----------ATRLE 52
++L A+ L+R ++ + T++ E +LALA + V E E K A R +
Sbjct: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
Query: 53 KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEET----NRSLRKAE 108
EL Q + + + + ++ E L+ + +I ELE++ K +
Sbjct: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQ 484
Query: 109 EELQDI-------KEKISKGEYGNAGIMAEVEELRKRVLDME--GKDEELIKMEEQCRDL 159
EL+D K +I + E A + EV ELR+R+ + G + + + ++ L
Sbjct: 485 RELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSL 544
Query: 160 NKRLE-------------------RETLQSKDFK---LEVEKLSKRIMALEKLEDAFNKS 197
++LE RE K+ K EKLSK +L+ + NK
Sbjct: 545 QEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE 604
Query: 198 KQECYSL-KCNLEKERMTTKQLSQEL-----ESLKVRIKELEAIESRLEKTEFTLKEDLT 251
+ +L K LE + +Q +EL + L E +++++EK + ++
Sbjct: 605 NSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIE 664
Query: 252 KLK----TLTVMFVDERKTMSEKL----KKTEDKLQAASSQL-QVEQNKVTTVTEKL--I 300
L+ + E + + KL K+ E+ L+A S+L + E + + + L +
Sbjct: 665 NLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL 724
Query: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL--LSRVNM-----LKNRLQ 353
+E + +K ++ K TK D+ ++LKA EEK DL L + + +K Q
Sbjct: 725 QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 784
Query: 354 SLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTE 413
LEA EK ++ +++ E++K +++E++ +LKL + ++++L +
Sbjct: 785 QLEAAEKQIKHLEIEKNA---------ESSKASSITRELQGRELKLTN---LQENLSEVS 832
Query: 414 DEYETLERRYANERDKAQFLSKELEHVK--MELAKYKLAEKTE-----TSHEQWLFKRLQ 466
ETLE+ ++K S+E V+ M+ KL +K E +S + L + L
Sbjct: 833 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA 892
Query: 467 EEEAKSGHLSREVDAL---KEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 523
+ EAK + L KEK+ +A I + GD+S K+N + R+
Sbjct: 893 DMEAKFREKDEREEQLIKAKEKLENDIAE---IMKMSGDNSSQLTKMNDELRLKE---RD 946
Query: 524 IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSL 575
+E L +L + + L+ S I D V +++ Q EA + K L
Sbjct: 947 VEELQLKLTKANENASFLQKS-----IEDMTVKAEQSQQEAAKKHEEEKKEL 993
Score = 91.3 bits (225), Expect = 4e-18
Identities = 121/551 (21%), Positives = 242/551 (43%), Gaps = 58/551 (10%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKL----ALAEARVQEEEQKATRLEKELQTQ 58
V E + L A+ Q + I T+ K T KL AL +A E + + +L ++L+
Sbjct: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS-SEGKSEMKKLRQQLEAA 789
Query: 59 TTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI 118
+ + A+ + S R+LQ + L+ + L E ++ E+ELQ +KEK
Sbjct: 790 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 849
Query: 119 SKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE 178
++ + ++E V + K+E+ + DL K E F+ + E
Sbjct: 850 AEASEEAVSVQRSMQET---VNKLHQKEEQFNMLSS---DLEKLRENLADMEAKFREKDE 903
Query: 179 KLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESR 238
+ + I A EKLE+ + + L K + +++E L++++ + S
Sbjct: 904 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 963
Query: 239 LEKT--EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVT 296
L+K+ + T+K + ++ + +E+K + KL E K++ + +Q Q + + T
Sbjct: 964 LQKSIEDMTVKAEQSQQEAAK-KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT 1022
Query: 297 EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNR----- 351
+ +KT EE + ++ K D ++KLK E+ + LL + L+ +
Sbjct: 1023 SE----------TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAK 1072
Query: 352 --------LQSLEAIEKDFLKNKLNQDSGKSTTA-LHQENNKIKELS-QEVERLKLKLKD 401
+Q +E + K+ + + + K T A L E + +KE + + VE L K K+
Sbjct: 1073 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN-KSKE 1131
Query: 402 MKAIEDDLMKT-EDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQW 460
+ +E+ M+ E ETL++ A + + L +E + EL + + TSH+
Sbjct: 1132 LLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR---SRDEVTSHQ-- 1186
Query: 461 LFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDL 520
+L+EE + L+ ++ +K++ +++ D + + LQK ++ +
Sbjct: 1187 ---KLEEERSV---LNNQLLEMKKRESKFIKDAD------EEKASLQKSISITSALLTEK 1234
Query: 521 GREIENLTKEL 531
E+E L E+
Sbjct: 1235 DAELEKLRNEV 1245
Score = 75.9 bits (185), Expect = 2e-13
Identities = 110/506 (21%), Positives = 220/506 (43%), Gaps = 41/506 (8%)
Query: 72 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN----AG 127
K++ + L++K + + + E + + KA + +I+++++ G+
Sbjct: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE 405
Query: 128 IMAEVEELRKRVLDMEGKDEELI-KMEEQCR---DLNKRLERETLQSKDFKLEVEKLSKR 183
+ A++++LR V + + EL+ ++EE+ R DL R+E E++ D + + + R
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHAR 465
Query: 184 IMALEKLEDAFNKSKQECYSLKCNLEKERMTT---KQLSQELES-LKVRIKELEAIESRL 239
I LE+ F K+K + L+ LE R+ T K ELE L +R++E+ + RL
Sbjct: 466 IKELEQ-SLLFEKTKAD--KLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRL 522
Query: 240 EKTE--------FTLKEDLTKLKT-LTVMFVDERK---TMSEKLKKTEDKLQAASSQLQV 287
E + +L ++++ L+ L V D ++ ++ E E+ Q L
Sbjct: 523 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 582
Query: 288 EQNKVTTVTEKLIEETKRALKSKTDV----EEKMYSVTKERDDLKNKLKAEEEKG-NDLL 342
K++ E L + + A K +DV + K+ + +LK KG
Sbjct: 583 ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 642
Query: 343 SRVNMLKNRLQSLEAIEKDFLKNKLNQ-DSGKSTTALHQENNKIKELSQEVERLKLKLKD 401
+ LK +++ + + ++N NQ DS ++ A E + K + +K K
Sbjct: 643 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKV----IKEKENS 698
Query: 402 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWL 461
++AI L K ED++ N+ +A+ KELE ++ + + TS +
Sbjct: 699 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758
Query: 462 FKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ--QENRNRD 519
++L + +A S +K+ + A E I HL+ + + K + +E + R+
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
Query: 520 LGREIENLTKELERYRHFSKSLRPSL 545
L ++ NL + L ++L L
Sbjct: 819 L--KLTNLQENLSEVSQVKETLEKEL 842
Score = 62.8 bits (151), Expect = 1e-09
Identities = 94/418 (22%), Positives = 180/418 (43%), Gaps = 90/418 (21%)
Query: 10 TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTI 69
++QLT +++ + +E KL A + A+ L+K ++ T K Q Q
Sbjct: 930 SSQLTKMNDELRLKERDVEELQLKLTKAN-------ENASFLQKSIEDMTVKAEQSQQEA 982
Query: 70 MAKLTNEDSQNRQLQQKLAALSRQID-------ELEE-----TNRSLRKAEEELQ----- 112
K + + ++L++KL+ L ++++ EL+ T+ + K EE LQ
Sbjct: 983 AKK---HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKT 1039
Query: 113 --DIKEKISKGEYGNAGIMAEVEELRKR---------------VLDMEGKDE-ELIKMEE 154
D ++K+ N+G++ E+EELRK+ +++ K++ E + E
Sbjct: 1040 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLE 1099
Query: 155 QCRDLNKRLERE--TLQSKDFKLEVEKL--SKRIMALE--KLED-----------AFNKS 197
+ N +L+ E TL+ + K VE+L SK ++ +E K+E+ A KS
Sbjct: 1100 DTKQTNAKLQNELDTLKENNLK-NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1158
Query: 198 KQECYSLKCNLE--------KERMTTKQ-LSQELESLKVRIKELEAIESRLEKTEFTLKE 248
+Q + N++ ++ +T+ Q L +E L ++ E++ ES+ K K
Sbjct: 1159 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA 1218
Query: 249 DLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTV------------- 295
L K ++T + E+ EKL+ L+ ++ + + V T+
Sbjct: 1219 SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN 1278
Query: 296 TEKLIEETKRALKSK-----TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
E ++E KR L S T +E + + D L + + + K DL +V M+
Sbjct: 1279 LELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1336
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 108 bits (269), Expect = 3e-23
Identities = 105/547 (19%), Positives = 254/547 (46%), Gaps = 73/547 (13%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ T +F + +D +L +++ ++L++KL L ++ ++L+ ++
Sbjct: 842 KSAETEKEMATMKEEFQKTKD----ELAKSEAKRKELEEKLVTLVQEKNDLQ---LQVQA 894
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNKR 162
E L D +E+ + + A+++E+ +R D E + EL K+E++C +L K
Sbjct: 895 ESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 954
Query: 163 LERETLQSKDFKLE-------VEKLSKRIMALEK-----------LEDAFNKSKQECYSL 204
++ L + E V+ L++ + L++ L++A ++ + +
Sbjct: 955 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014
Query: 205 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 264
+ + T +L Q++E L+ +++ + + LE+ + L+ DL + + +++
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 265 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIE------------ETKRALKSKTD 312
+ + E+LKK + + S+++ EQ +K+ E E +RA ++KT+
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 313 VEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS- 371
+ Y+ +E ++L +L EE G +++ + K R + +D + L ++
Sbjct: 1135 KQRSDYA--RELEELSERL---EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAM 1189
Query: 372 --------GKSTTALHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETL 419
S L ++ + ++ + Q++E+ KL++ D+ + + + K++ E +
Sbjct: 1190 VAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKI 1249
Query: 420 ERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR-- 477
R ++ +A+ ++E++ EL K +TE L ++L+E+E+ LSR
Sbjct: 1250 CRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGE---LSRQLEEKESIVSQLSRSK 1306
Query: 478 -----EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLT 528
+ + LK ++ E ++ + H + D +L+++ +++ +L R +
Sbjct: 1307 QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN 1366
Query: 529 KELERYR 535
E+ ++R
Sbjct: 1367 SEVAQWR 1373
Score = 90.9 bits (224), Expect = 5e-18
Identities = 127/621 (20%), Positives = 254/621 (40%), Gaps = 81/621 (13%)
Query: 13 LTLQRQKIQELTTNAKETHTKLALA----EARVQEEEQKA----------TRLEKELQTQ 58
L LQ Q E +A+E +L A EA+++E ++A T +++L+ +
Sbjct: 888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 947
Query: 59 TTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI 118
++ +D D + L + + + K+ L+ ++ L+ET L + ++ LQ+ ++
Sbjct: 948 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQA 1007
Query: 119 SKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSK-DFKLEV 177
+V L K +E + E+L EQ + L LER + + D KL
Sbjct: 1008 LDDLQAEED---KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ 1064
Query: 178 EKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE---- 233
E + ++L++ K E L+ +E E+ Q ++++ L+ RI+ELE
Sbjct: 1065 ESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Query: 234 ---AIESRLEKTEFTLKEDLTKL------------------KTLTVMFVDERKTMSEKLK 272
A ++ EK +L +L K F+ R+ + E
Sbjct: 1125 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 1184
Query: 273 KTEDKLQA-------ASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD 325
+ E + A + ++L + + + V +KL +E D+ M SV+K +
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244
Query: 326 DLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI 385
+L+ + E++ ++ + ++ L L K++L ++G+ + L ++ + +
Sbjct: 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTT-----QKSRLQTEAGELSRQLEEKESIV 1299
Query: 386 KELS-------QEVERLKLKL----KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLS 434
+LS Q+ E LK +L K A+ L + + + L +Y E++ L
Sbjct: 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1359
Query: 435 KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMA--- 491
+ L E+A+++ T +E +R +E E L++ + +E++ A
Sbjct: 1360 RALSKANSEVAQWR------TKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCA 1413
Query: 492 -TEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR----HFSKSLRPSLN 546
E LQG+ L + + + L ++ N K L ++ L SL
Sbjct: 1414 SLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLK 1473
Query: 547 GRRISDPQVFS-KEVQTEAVD 566
R ++F K EA+D
Sbjct: 1474 ESRSLSTELFKLKNAYEEALD 1494
Score = 86.3 bits (212), Expect = 1e-16
Identities = 132/574 (22%), Positives = 243/574 (42%), Gaps = 71/574 (12%)
Query: 99 ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE----VEELRKRVLDMEGKDEELIKMEE 154
ET + + +EE Q K++++K E + + V+E L ++ + E L+ EE
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904
Query: 155 QCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT 214
+C L K K ++E K + + E+ N E + K LE E
Sbjct: 905 RCDQLIKA-----------KFQLEAKIKEVTERAEDEEEIN---AELTAKKRKLEDE--- 947
Query: 215 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 274
+L ++++ L++ + ++E + E L E+L+ L E+K + E ++
Sbjct: 948 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQA 1007
Query: 275 EDKLQAASSQLQVEQNKVTTV--TEKLIEETKRALKSKTDVEEKM-YSVTKERDDLKNKL 331
D LQA E++KV ++ T+ +E+ L+S + E+K+ + + + L+ L
Sbjct: 1008 LDDLQA-------EEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDL 1060
Query: 332 KAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQE 391
K +E DL + L RL+ +KDF +L T Q KIKEL
Sbjct: 1061 KLAQESILDLENDKQQLDERLK-----KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQAR 1115
Query: 392 VERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHV-KMELAKYKLA 450
+E L+ +++ +A T + E YA E ++ LS+ LE + + +L
Sbjct: 1116 IEELEEEIEAERA-------TRAKTEKQRSDYARELEE---LSERLEEAGGVTSTQIELN 1165
Query: 451 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMA-TEDLICHLQGDHSVLQKK 509
+K E ++L R EEA H V AL++K + +A + I +LQ L+K+
Sbjct: 1166 KKREA---EFLKLRRDLEEATLQH-EAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1221
Query: 510 LNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLN---------GRRISDPQVFSKEV 560
++ + DL +E+++K ++L L+ R +S+ +
Sbjct: 1222 KSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRL 1281
Query: 561 QTEAVD-----NEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVLSFKCSQST-P 614
QTEA + E S + + Q EE + Q E+ N + L+ S
Sbjct: 1282 QTEAGELSRQLEEKESIVSQLSRSKQAFTQQT-EELKRQLEEENKAKNALAHALQSSRHD 1340
Query: 615 CPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQ 648
C + R+ + + +EG + + +K N+ Q
Sbjct: 1341 CDLLRE---QYEEEQEGKAELQRALSKANSEVAQ 1371
Score = 84.7 bits (208), Expect = 3e-16
Identities = 117/559 (20%), Positives = 236/559 (42%), Gaps = 77/559 (13%)
Query: 36 LAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ-------QKLA 88
L+EAR + EE + R EL TQ ++ + + +L ++S QL Q+
Sbjct: 1257 LSEARGKNEEIQ--RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTE 1314
Query: 89 ALSRQIDELEETNRS--------------LRKAEEELQDIKEKISKG------------- 121
L RQ++E + + LR+ EE Q+ K ++ +
Sbjct: 1315 ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1374
Query: 122 EYGNAGIM--AEVEELRKRVLD-MEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE 178
+Y I E+EE +K++ ++ +E++ + +C L K +R + +D ++VE
Sbjct: 1375 KYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVE 1434
Query: 179 KLSKRIMALEKLEDAFNKS----KQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEA 234
+ + AL+K + F+K K +C + LE ++ LS EL LK A
Sbjct: 1435 RANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLK------NA 1488
Query: 235 IESRLEKTEFTLKEDLT---KLKTLTVMFVDERKTMSEKLK-KTEDKLQAASSQLQVEQN 290
E L++ E +E+ ++ LT + KT+ E K + + +L+ A QL +E+
Sbjct: 1489 YEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEA 1548
Query: 291 KVTTVTE--KLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
+ E K++ + K++++ K+ +E + LK + E L
Sbjct: 1549 EAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRS 1608
Query: 349 KNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDD 408
+N EAI LK K+ D + L N + E + + ++ +LKD + DD
Sbjct: 1609 RN-----EAIR---LKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDD 1660
Query: 409 LMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK---TETSHEQWLFKRL 465
++ + E L+ + A +A L E+E ++ L + + A K E + L
Sbjct: 1661 ALRGQ---EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLL 1717
Query: 466 QEEEAKSGHLSREVDA--------LKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRN 517
+ H ++++ +++ + E+ D +++ ++L ++++ +
Sbjct: 1718 HTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTS 1777
Query: 518 RDLGREIENLTKELERYRH 536
L R +NL + ++ +H
Sbjct: 1778 AHLERMKKNLEQTVKDLQH 1796
Score = 83.6 bits (205), Expect = 8e-16
Identities = 107/528 (20%), Positives = 230/528 (43%), Gaps = 51/528 (9%)
Query: 14 TLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKL 73
+L++ K Q L ++ + A + ++K +K L TK + Q + A L
Sbjct: 1414 SLEKTK-QRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL 1472
Query: 74 TNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVE 133
S + +L + A +D+LE R + E+E+ D+ E+I++ N + E+E
Sbjct: 1473 KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAE----NGKTIHELE 1528
Query: 134 ELRKRVLDMEGKDEELIKME-------EQCRDLNKRLERETLQSK-DFKL-----EVEKL 180
+ RK++ ++E D +L E E+ + L +LE ++S+ D K+ E+E+L
Sbjct: 1529 KSRKQI-ELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQL 1587
Query: 181 SKR----IMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-QLSQELESLKVRIKELEAI 235
+ + ++ DA +S+ E LK +E + + QLS +K L ++
Sbjct: 1588 KRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSV 1647
Query: 236 ESRLEKTEFTL------KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQ 289
+ +L+ T+ L +EDL + + + + E+L+ T ++ + A + E
Sbjct: 1648 QGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQEL 1707
Query: 290 NKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK 349
+ L + + +K +E + + E +D + EEK ++ M+
Sbjct: 1708 LDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMA 1767
Query: 350 NRLQS-------LEAIEKDF---LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL 399
L+ LE ++K+ +K+ ++ AL +I++L + L+ +L
Sbjct: 1768 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFEL 1827
Query: 400 KDMKAIEDDLMKTEDEYE--TLERRYANERDKAQFLSKE--LEHVKMELAKYK-LAEKTE 454
+ + + +K +YE E Y +E D+ L + ++ +++++ YK AE+ +
Sbjct: 1828 EGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEAD 1887
Query: 455 TSHEQWLFK------RLQEEEAKSGHLSREVDALKEKIHEYMATEDLI 496
L K L+E E ++ +V+ L+ K ++ ++ ++
Sbjct: 1888 EQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVV 1935
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 108 bits (269), Expect = 3e-23
Identities = 114/546 (20%), Positives = 249/546 (45%), Gaps = 71/546 (13%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ +F + ++ +L +++ ++L++K+ L ++ ++L+ ++
Sbjct: 845 KSAETEKEMANMKEEFEKTKE----ELAKTEAKRKELEEKMVTLMQEKNDLQ---LQVQA 897
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 161
+ L D +E+ + + A+++E+ +R D E + EL K+E++C +L K
Sbjct: 898 EADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 957
Query: 162 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 207
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 958 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1017
Query: 208 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 264
+K TK +L Q+++ L+ +++ + I LE+ + L+ DL + T+ +++
Sbjct: 1018 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDK 1077
Query: 265 KTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 314
+ + EKLKK E ++ QA QLQ + ++ E+L EE + S+ E
Sbjct: 1078 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 315 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKS 374
++ +++E +++ +L EE G +++ M K R + + +D L+ Q +
Sbjct: 1138 KQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRD-LEEATLQHEATA 1193
Query: 375 TTALHQENNKIKELSQEV---ERLKLKLK----DMKAIEDDLMKTEDEYETLERRYANER 427
T + + + EL +++ +R+K KL+ +MK DDL ET+ + N
Sbjct: 1194 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL---ASNMETVSKAKGNLE 1250
Query: 428 DKAQFLSKELEHVK------MELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSR--- 477
+ L +L +K L A++ E + R L E++ LSR
Sbjct: 1251 KMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ 1310
Query: 478 ----EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLTK 529
+++ LK ++ E + + + H + D +L+++ +++ +L R +
Sbjct: 1311 AFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS 1370
Query: 530 ELERYR 535
E+ ++R
Sbjct: 1371 EVAQWR 1376
Score = 98.6 bits (244), Expect = 2e-20
Identities = 119/611 (19%), Positives = 262/611 (42%), Gaps = 72/611 (11%)
Query: 1 MVVDEQQRLTAQLTLQ---------RQKIQELTTNAKETHTKLALAEARVQEEEQ---KA 48
MV Q++ QL +Q ++ +L + K+ R ++EE+ +
Sbjct: 881 MVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAEL 940
Query: 49 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAE 108
T +++L+ + ++ +D D + L + + + K+ L+ ++ L+ET L K +
Sbjct: 941 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEK 1000
Query: 109 EELQDIKEKI---SKGEYGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 164
+ LQ+ ++ + E + + + +L ++V D+EG E+ K+ ++LE
Sbjct: 1001 KALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE 1060
Query: 165 RETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELES 224
+ +++ +++E ++L++ K + E L+ +E E+ QL ++++
Sbjct: 1061 GDLKLAQESTMDIEN------DKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKE 1114
Query: 225 LKVRIKELE-------AIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDK 277
L+ RI+ELE A ++ EK L +L ++ E KK E +
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 278 LQAASSQLQ--VEQNKVTTVT---------EKLIEETKRALKSKTDVEEKMYSVTKERDD 326
Q L+ Q++ T T +L E+ + K +E++ + E DD
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1234
Query: 327 LKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKD---------FLKNKLNQDSGKSTTA 377
L + ++ + +L L+++L ++ E++ + +L +SG+ +
Sbjct: 1235 LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ 1294
Query: 378 LHQENNKIKELS-------QEVERLKLKL----KDMKAIEDDLMKTEDEYETLERRYANE 426
L +++ + +LS Q++E LK +L K A+ L + + + L +Y E
Sbjct: 1295 LDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE 1354
Query: 427 RDKAQFLSKELEHVKMELAKYKLAEKTET--------SHEQWLFKRLQEEEAKSGHLSRE 478
++ L + + E+A+++ +T+ ++ L +RLQ+ E ++ +
Sbjct: 1355 QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Query: 479 VDAL-KEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERY 534
+L K K EDL+ ++ ++ +Q N ++ L ++ E ELE
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1474
Query: 535 RHFSKSLRPSL 545
+ S+SL L
Sbjct: 1475 QKESRSLSTEL 1485
Score = 93.6 bits (231), Expect = 7e-19
Identities = 132/688 (19%), Positives = 288/688 (41%), Gaps = 139/688 (20%)
Query: 4 DEQQRLTAQLTLQRQKIQ----ELTTNAKETHTKLALA----EARVQEEEQKATRLEKEL 55
+EQQRL LT QR ++Q E + E T ++ +A Q+ E+ +LE+E+
Sbjct: 1268 EEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327
Query: 56 QTQTTKFH------QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI--------------- 94
+ ++ H D D + + E +LQ+ ++ + ++
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387
Query: 95 DELEETNRSLRK----AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI 150
+ELEE + L + AEE ++ + K + E + EVE+L ++D+E +
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL---MIDVERTNAACA 1444
Query: 151 KMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC 206
++++ R+ +K L + ++ E+E K +L K+++A+ +S + +LK
Sbjct: 1445 ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKR 1504
Query: 207 ---NLEKE------------------RMTTKQLSQELESLKVRIKELEA----------- 234
NL++E KQ+ QE L+ ++E EA
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILR 1564
Query: 235 -------IESRLEKTEFTLKEDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQA 280
++S +++ E++ ++K + V+ + T+ +++ D K++
Sbjct: 1565 IQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1624
Query: 281 ASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGND 340
++++++ N + + + + D + + + ++DLK +L E + N
Sbjct: 1625 DLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL 1684
Query: 341 LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLK 396
L + + L+ L+ E K + L D+ + LH +N + K+L ++ +++
Sbjct: 1685 LQAEIEELRATLEQTERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQIQ 1742
Query: 397 LKLKDM------------KAIED------DLMKTEDEYETLERRYAN----------ERD 428
+++D+ KAI D +L K +D LER N D
Sbjct: 1743 GEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1802
Query: 429 KAQFLS-----KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALK 483
+A+ L+ K+++ ++ + + + ++E K L++ E K L+ + + +
Sbjct: 1803 EAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDR 1862
Query: 484 EKIHEYMATEDLICHLQG---DHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 540
+ I + +DL+ LQ + ++ +Q N N R I++ +E E ++S
Sbjct: 1863 KNI---LRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAES 1919
Query: 541 LRPSLNGRRISDPQVFSKEVQTEAVDNE 568
+++ +V S+EV T+ + E
Sbjct: 1920 --------QVNKLRVKSREVHTKIISEE 1939
Score = 89.7 bits (221), Expect = 1e-17
Identities = 119/568 (20%), Positives = 243/568 (42%), Gaps = 91/568 (16%)
Query: 16 QRQKIQ-ELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 74
Q +KI+ +L ++ L LA+ + E +L+++L+ K + + +K+
Sbjct: 1044 QEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLK----KKEFEMSGLQSKIE 1099
Query: 75 NEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEE 134
+E + QLQ+K+ L +I+EL EEE++ + +K E + + E+EE
Sbjct: 1100 DEQALGMQLQKKIKELQARIEEL----------EEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 135 LRKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKL 190
+ +R+ + G I+M E + + + + LE TLQ + + K K ++ +L
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK--KHADSVAEL 1207
Query: 191 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDL 250
+ + ++ +K LEKE+ ++ E++ L ++ + + LEK L++ L
Sbjct: 1208 GEQIDNLQR----VKQKLEKEK---SEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQL 1260
Query: 251 TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL----------I 300
+++KT +E++ + L +LQ S + + ++ T+ +L I
Sbjct: 1261 SEIKTKE----EEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQI 1316
Query: 301 EETKRAL----KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 356
EE KR L K+K+ + + S + D L+ + + E+E +L R S
Sbjct: 1317 EELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAEL--------QRAMSKA 1368
Query: 357 AIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV-ERLKLKLKDMKAIEDDLMKTEDE 415
E + K D+ + T L + K+ + Q+ E ++ ++E + ++E
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNE 1428
Query: 416 YETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHL 475
E L L K+ + LA++K +K E +H + L+ + +S L
Sbjct: 1429 VEDLMIDVERTNAACAALDKKQRNFDKILAEWK--QKCEETHAE-----LEASQKESRSL 1481
Query: 476 SREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 535
S E+ +K E + +L + N++L +EI +LT+++
Sbjct: 1482 STELFKIKNAYEESL-----------------DQLETLKRENKNLQQEISDLTEQIAE-- 1522
Query: 536 HFSKSLRPSLNGRRISDPQVFSKEVQTE 563
G+RI + + K+V+ E
Sbjct: 1523 ----------GGKRIHELEKIKKQVEQE 1540
Score = 68.2 bits (165), Expect = 3e-11
Identities = 90/490 (18%), Positives = 208/490 (42%), Gaps = 60/490 (12%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 62
+D+ + L + +Q+I +LT E ++ E ++ EQ+ + L+ L+
Sbjct: 1496 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASL 1555
Query: 63 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE 122
++ I+ + ++ +K+A +ID+++ + + ++ + D
Sbjct: 1556 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLD--------- 1606
Query: 123 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQS--------KDFK 174
AE+ + + + +L +ME Q N R+ E L++ KD +
Sbjct: 1607 -------AEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN-RMAAEALRNYRNTQAILKDTQ 1658
Query: 175 LEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
L ++ + L++ +E N + E L+ LE+ + K QEL R++
Sbjct: 1659 LHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQ 1718
Query: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 290
L + L T+ L+ D+++++ + E + EK KK + +L+ EQ+
Sbjct: 1719 LLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQD 1778
Query: 291 KVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
+ +K +E+T + L+ + D E++ LK +++ L +RV L
Sbjct: 1779 TSAHLERMKKNLEQTVKDLQHRLDEAEQL------------ALKGGKKQIQKLEARVREL 1826
Query: 349 KNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDD 408
+ ++S + K N ++ K L + K+KEL+ + E + K++ ++D
Sbjct: 1827 EGEVES---------EQKRNVEAVK---GLRKHERKVKELTYQTEEDR---KNILRLQDL 1871
Query: 409 LMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEE 468
+ K + + ++ +R+ +++ + ++ EL + + E+ + + Q R++
Sbjct: 1872 VDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE--ERADIAESQVNKLRVKSR 1929
Query: 469 EAKSGHLSRE 478
E + +S E
Sbjct: 1930 EVHTKIISEE 1939
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 107 bits (266), Expect = 6e-23
Identities = 106/545 (19%), Positives = 258/545 (47%), Gaps = 69/545 (12%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ + +F + ++ L +++ ++L++K+ +L ++ ++L+ ++
Sbjct: 841 KSAEREKEMASMKEEFTRLKEA----LEKSEARRKELEEKMVSLLQEKNDLQ---LQVQA 893
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 161
++ L D +E+ + + A+V+E+ +R+ D E + EL K+E++C +L +
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRD 953
Query: 162 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 207
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 954 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE 1013
Query: 208 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 264
+K TK +L Q+++ L+ +++ + + LE+ + L+ DL + + +++
Sbjct: 1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1073
Query: 265 KTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 314
+ + E+LKK + +L QA SQLQ + ++ E+L EE + ++ VE
Sbjct: 1074 QQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVE 1133
Query: 315 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS--- 371
+ +++E +++ +L EE G ++ M K R + + +D + L ++
Sbjct: 1134 KLRSDLSRELEEISERL---EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190
Query: 372 ------GKSTTALHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETLER 421
S L ++ + ++ + Q++E+ KL+L D+ + + ++K + E + R
Sbjct: 1191 ALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCR 1250
Query: 422 RYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR---- 477
++ ++ + ++E + +L + +TE L ++L E+EA L+R
Sbjct: 1251 TLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE---LSRQLDEKEALISQLTRGKLT 1307
Query: 478 ---EVDALKEKIHEYMATEDLICH----LQGDHSVLQKKLNQQENRNRDLGREIENLTKE 530
+++ LK ++ E + ++ + H + D +L+++ ++ +L R + E
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367
Query: 531 LERYR 535
+ ++R
Sbjct: 1368 VAQWR 1372
Score = 93.6 bits (231), Expect = 7e-19
Identities = 134/628 (21%), Positives = 278/628 (44%), Gaps = 60/628 (9%)
Query: 3 VDEQQRLTAQLTLQR----QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQ 58
+DE++ L +QLT + Q++++L +E K A A + + L +E +
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEE-EVKAKNALAHALQSARHDCDLLREQYEE 1349
Query: 59 TTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSL----RKAEEELQDI 114
T+ + +++K +E +Q R + A ++ +ELEE + L ++AEE ++ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYETDAI--QRTEELEEAKKKLAQRLQEAEEAVEAV 1407
Query: 115 KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 174
K S E + E+E+L ++D+E + ++++ R+ +K L + ++ +
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDL---MVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ 1464
Query: 175 LEVEKLSKRIMALE----KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK 230
E+E K +L KL++A+ +S + + K + + L+++L S I
Sbjct: 1465 SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIH 1524
Query: 231 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK----KTEDKLQAASSQLQ 286
ELE + +LE + L+ L + + + +E K + +L+ K E + + A +
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEAS--LEHEEGKILRAQLEFNQIKAEIERKLAEKDEE 1582
Query: 287 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 346
+EQ K + ++++ + +L ++T + V K+ + N+++ + N + +
Sbjct: 1583 MEQAKRNHL--RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQ 1640
Query: 347 MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENN----KIKELSQEVERLKLKLK 400
LQSL + L + + N D ++ + + NN +++EL VE+ + +
Sbjct: 1641 KQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTE---R 1697
Query: 401 DMKAIEDDLMKTEDEYETLERRYA---NERDKAQF----LSKELEHVKMELAKYKLAEKT 453
K E +L++T + + L + N++ K L E+E E + K
Sbjct: 1698 SRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKK 1757
Query: 454 ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 513
+ + + L++E+ S HL R +++ I +DL L + K +Q
Sbjct: 1758 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTI------KDLQHRLDEAEQIALKGGKKQ 1811
Query: 514 ENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYK 573
+ RE+EN ELE + K S+ G R S+ ++ QTE D K
Sbjct: 1812 LQKLEARVRELEN---ELEAEQ---KRNAESVKGMRKSERRIKELTYQTE------EDRK 1859
Query: 574 SLIPLERAVINGQLYEESENQDEDPNDE 601
+L+ L+ V QL ++ + + +E
Sbjct: 1860 NLLRLQDLVDKLQLKVKAYKRQAEEAEE 1887
Score = 82.8 bits (203), Expect = 1e-15
Identities = 110/558 (19%), Positives = 221/558 (39%), Gaps = 65/558 (11%)
Query: 6 QQRLTAQLTLQRQKI-------QELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQ 58
+++L L L ++ I Q+L K+ +L AR+++E+ ++L+K+L+
Sbjct: 1052 KRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKEL 1111
Query: 59 TTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSL-----------RKA 107
+ + ++ + A E + ++++ + LSR+++E+ E +K
Sbjct: 1112 QARIEELEEELEA----ERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR 1167
Query: 108 EEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGK-DEELIKMEEQCRDLNKRLERE 166
E E Q ++ + + + A LRK+ D + E++ ++ + L K
Sbjct: 1168 EAEFQKMRRDLEEATLQHE---ATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEF 1224
Query: 167 TLQSKDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQEL 222
L+ D +E++ K LEK LED N+ + + + ++ +L E
Sbjct: 1225 KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 223 ESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAAS 282
L ++ E EA+ S+L + + T + L LK V + ++ L+
Sbjct: 1285 GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR 1344
Query: 283 SQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLL 342
Q + E + L + + +T E T+E ++ K KL ++ + +
Sbjct: 1345 EQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAV 1404
Query: 343 SRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL--- 399
VN + SLE + H+ N+I++L +VER
Sbjct: 1405 EAVNA---KCSSLEKTK-------------------HRLQNEIEDLMVDVERSNAAAAAL 1442
Query: 400 -KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVK---MELAKYKLAEKTET 455
K + + L + + +YE + + + +A+ LS EL +K E ++ K E
Sbjct: 1443 DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1502
Query: 456 SHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQEN 515
+ Q L E+ SG E+ EK+ + + E + LQ + L +E
Sbjct: 1503 KNLQEEISDLTEQLGSSGKTIHEL----EKVRKQLEAEKM--ELQSALEEAEASLEHEEG 1556
Query: 516 RNRDLGREIENLTKELER 533
+ E + E+ER
Sbjct: 1557 KILRAQLEFNQIKAEIER 1574
Score = 73.2 bits (178), Expect = 1e-12
Identities = 87/432 (20%), Positives = 185/432 (42%), Gaps = 35/432 (8%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
+E LT QL + I EL K+ + ++ ++E E E ++ +F+
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
Q + I KL +D + Q ++ R +D L+ + + ++ E +K+K+
Sbjct: 1567 QIKAEIERKLAEKDEEMEQAKRNHL---RVVDSLQTSLDAETRSRNEALRVKKKME---- 1619
Query: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKR 183
G + E+E + + + + ++Q + L L+ +Q D + L +
Sbjct: 1620 ---GDLNEME------IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN 1670
Query: 184 IMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE 243
I +E+ + +E L+ +E+ + K QEL R++ L + + L +
Sbjct: 1671 IAIVERRNNLLQAELEE---LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1727
Query: 244 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTV--TEKLIE 301
+ DL++L+T V E + EK KK + +L+ EQ+ + +K +E
Sbjct: 1728 KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1787
Query: 302 ETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKD 361
+T + L+ + D E++ LK +++ L +RV L+N L++ + +
Sbjct: 1788 QTIKDLQHRLDEAEQI------------ALKGGKKQLQKLEARVRELENELEAEQKRNAE 1835
Query: 362 FLK--NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL 419
+K K + + T ++ + L V++L+LK+K K ++ + + +
Sbjct: 1836 SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSK 1895
Query: 420 ERRYANERDKAQ 431
R+ +E D+A+
Sbjct: 1896 FRKVQHELDEAE 1907
Score = 68.9 bits (167), Expect = 2e-11
Identities = 99/487 (20%), Positives = 204/487 (41%), Gaps = 70/487 (14%)
Query: 42 QEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQ-------I 94
Q E + + + + L T+ K + + L +N+ LQ++++ L+ Q I
Sbjct: 1464 QSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTI 1523
Query: 95 DELEETNRSLRKAEEELQD-IKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKME 153
ELE+ + L + ELQ ++E + E+ I+ E + ++E K E +
Sbjct: 1524 HELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEM 1583
Query: 154 EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM 213
EQ + + R+ S D E ++ + +K+E N+ + + + +
Sbjct: 1584 EQAKRNHLRVVDSLQTSLD--AETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQK 1641
Query: 214 TTKQLSQELESLKVRI-------KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKT 266
K L L+ ++++ +L+ + +E+ L+ +L +L+ + RK
Sbjct: 1642 QVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL 1701
Query: 267 MSEKLKKTEDKLQAASSQ----------LQVEQNKVTTVTEKLIEETK----RALKSKTD 312
++L +T +++Q SQ + + +++ T E+ ++E + +A K+ TD
Sbjct: 1702 AEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITD 1761
Query: 313 VEEKMYSVTKERD---DLKNKLKAEEEKGNDLLSRVNML--------KNRLQSLEAIEKD 361
+ KE+D L+ K E+ DL R++ K +LQ LEA ++
Sbjct: 1762 AAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1821
Query: 362 FLKNKLNQD---SGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYET 418
L+N+L + + +S + + +IKEL+ + E + L ++ + D L Y
Sbjct: 1822 -LENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAY-- 1878
Query: 419 LERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSRE 478
+R A E + E L+K++ + HE L E E ++ +
Sbjct: 1879 --KRQAEEAE---------EQANTNLSKFR-----KVQHE------LDEAEERADIAESQ 1916
Query: 479 VDALKEK 485
V+ L+ K
Sbjct: 1917 VNKLRAK 1923
Score = 66.2 bits (160), Expect = 1e-10
Identities = 116/585 (19%), Positives = 242/585 (41%), Gaps = 79/585 (13%)
Query: 15 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 74
L R+ + +L TN + TH + E + ++ L + + + I ++
Sbjct: 650 LHRENLNKLMTNLRSTHPHFV--RCIIPNETKSPGVMDNPLVMHQLRCNGVLEGI--RIC 705
Query: 75 NEDSQNRQL----QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN----- 125
+ NR L +Q+ L+ + S + AE+ L + ++ ++G+
Sbjct: 706 RKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFF 765
Query: 126 -AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE-RETLQSKDFKLEVE----- 178
AG++ +EE+R L + +++ Q R + R+E ++ L+ +D L ++
Sbjct: 766 KAGLLGLLEEMRDERLS-----RIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRA 820
Query: 179 ----------KLSKRIMALEKL---EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 225
KL +I L K E K+E LK LEK K+L +++ SL
Sbjct: 821 FMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSL 880
Query: 226 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 285
+L+ + +E +L + + K M+E+L+ E+
Sbjct: 881 LQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM-------- 932
Query: 286 QVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK--AEEEKGNDLLS 343
++T KL +E + D+E + V KE+ +NK+K EE G D
Sbjct: 933 ---NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD--- 986
Query: 344 RVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMK 403
+ + + K+ K L + ++ L E +K+ L++ +L+ ++ D++
Sbjct: 987 ---------EIIAKLTKE--KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Query: 404 AIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK 463
+ K + E +R+ + Q +LE+ K +L + + E + L
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA---LNA 1092
Query: 464 RLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 523
R+++E+A L +++ L+ +I E+L L+ + + K E DL RE
Sbjct: 1093 RIEDEQALGSQLQKKLKELQARI------EELEEELEAERTARAK----VEKLRSDLSRE 1142
Query: 524 IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 568
+E +++ LE + S++ +N +R ++ Q ++++ + +E
Sbjct: 1143 LEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1186
Score = 62.4 bits (150), Expect = 2e-09
Identities = 80/377 (21%), Positives = 173/377 (45%), Gaps = 39/377 (10%)
Query: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQ 64
E ++ A++ + + E AK H ++ + +Q TR E K
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS---LQTSLDAETRSRNEALRVKKKMEG 1620
Query: 65 DQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYG 124
D + + +L++ + + Q+++ +L L++T L A D+KE I+ E
Sbjct: 1621 DLNEMEIQLSHANRMAAEAQKQVKSLQSL---LKDTQIQLDDAVRANDDLKENIAIVERR 1677
Query: 125 NAGIMAEVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
N + AE+EELR V E ++ELI+ E+ + L+ + Q K ++ +L
Sbjct: 1678 NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1737
Query: 181 SKRIM-ALEKLEDAFNKSKQ---ECYSLKCNLEKERMTT-------KQLSQELESLKVRI 229
+ A+++ +A K+K+ + + L+KE+ T+ K + Q ++ L+ R+
Sbjct: 1738 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1797
Query: 230 KELEAI-----ESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK---KTEDKLQAA 281
E E I + +L+K E ++E +L+ E+K +E +K K+E +++
Sbjct: 1798 DEAEQIALKGGKKQLQKLEARVRELENELEA-------EQKRNAESVKGMRKSERRIKEL 1850
Query: 282 SSQLQVEQN---KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKG 338
+ Q + ++ ++ + +KL + K + + EE+ + + ++++L EE+
Sbjct: 1851 TYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 339 NDLLSRVNMLKNRLQSL 355
+ S+VN L+ + + +
Sbjct: 1911 DIAESQVNKLRAKSRDI 1927
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 106 bits (265), Expect = 8e-23
Identities = 121/573 (21%), Positives = 251/573 (43%), Gaps = 83/573 (14%)
Query: 40 RVQEEEQKATRL---EKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 96
R++EEE+ + L ++ L+ + + +D D + LT + + + K+ LS ++
Sbjct: 929 RLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTA 988
Query: 97 LEETNRSLRKAEEELQDIKEK----ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM 152
LEE L K ++ LQ+ ++ + E G++ +L ++ D+EG E+ K+
Sbjct: 989 LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKL 1048
Query: 153 EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKER 212
++LE + S++ +++E ++I E+ K + E L+ ++ E+
Sbjct: 1049 RADLERAKRKLEGDLKMSQESIMDLENDKQQI------EEKLKKKEFELSQLQAKIDDEQ 1102
Query: 213 MTTKQLSQELESLKVRIKELE-------AIESRLEKTEFTLKEDLTKL------------ 253
+ + Q ++++ L+ RI+ELE + +++EK L +L ++
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATS 1162
Query: 254 ------KTLTVMFVDERKTMSE---------------------KLKKTEDKLQAASSQLQ 286
K F R+ + E +L + D LQ +L+
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLE 1222
Query: 287 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 346
E++++ + + + KSK+++E +V +D +++KA++E+ L+ +N
Sbjct: 1223 KEKSELKMEIDDMASNIEALSKSKSNIERTCRTV----EDQFSEIKAKDEQQTQLIHDLN 1278
Query: 347 MLKNRLQSL--EAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKA 404
M K RLQ+ E + K L KS AL Q+ ++EL +++E + K A
Sbjct: 1279 MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQ---LEELKRQMEE---ETKAKNA 1332
Query: 405 IEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTET--------S 456
+ L + + + L +Y E++ L + L E+A+++ +T+
Sbjct: 1333 MAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1392
Query: 457 HEQWLFKRLQEEEAKSGHLSREVDAL-KEKIHEYMATEDLICHLQGDHSVLQKKLNQQEN 515
++ L +RLQE E + + + +L K K EDL+ L+ H+ +Q N
Sbjct: 1393 AKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN 1452
Query: 516 RNRDLG---REIENLTKELERYRHFSKSLRPSL 545
++ L ++++ ELE + S+SL L
Sbjct: 1453 FDKVLAEWKQKLDESQAELEAAQKESRSLSTEL 1485
Score = 99.8 bits (247), Expect = 1e-20
Identities = 106/543 (19%), Positives = 253/543 (46%), Gaps = 65/543 (11%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ T F + ++ +L +++ ++L++K+ +L ++ ++L+ ++
Sbjct: 845 KSAEAEKEMATMKEDFERTKE----ELARSEARRKELEEKMVSLLQEKNDLQ---LQVQS 897
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNKR 162
E L D +E+ + A+V+EL +R+ + E + EL+ +E++C L +
Sbjct: 898 ETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD 957
Query: 163 LERETLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSK---QECYSLKCN---LE 209
++ L + E V+ LS+ + ALE+ K K QE + + +E
Sbjct: 958 IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 210 KERMT-----TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 264
++++ +L Q+ + L+ +++ + + + LE+ + L+ DL + + +++
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK 1077
Query: 265 KTMSEKLKKTE----------DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 314
+ + EKLKK E D Q S Q Q + ++ E+L EE + + +E
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137
Query: 315 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKS 374
++ + +E +++ +L EE +++ M K R + + +D + L ++ +
Sbjct: 1138 KQRSDLARELEEISERL---EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194
Query: 375 TTALHQENN------------KIKE-LSQEVERLKLKLKDMKAIEDDLMKTEDEYE---- 417
T Q ++ ++K+ L +E LK+++ DM + + L K++ E
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCR 1254
Query: 418 TLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGH-LS 476
T+E +++ + K + ++ + + M+ A+ + + E SH + L + KS L+
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNMQKARLQ-TQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 477 REVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLTKELE 532
++++ LK ++ E ++ + H + D +L+++ +++ +L R + E+
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVA 1373
Query: 533 RYR 535
++R
Sbjct: 1374 QWR 1376
Score = 90.5 bits (223), Expect = 6e-18
Identities = 119/563 (21%), Positives = 241/563 (42%), Gaps = 60/563 (10%)
Query: 4 DEQQ-RLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 62
DEQQ +L L +Q+ ++Q T N + +H RV+E+E ++L K Q T
Sbjct: 1267 DEQQTQLIHDLNMQKARLQ--TQNGELSH--------RVEEKESLISQLTKSKQALT--- 1313
Query: 63 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS--- 119
Q + + ++ E + L + D L E ++A+ ELQ K +
Sbjct: 1314 -QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372
Query: 120 ---KGEYGNAGIM--AEVEELRKRVLD-MEGKDEELIKMEEQCRDLNKRLERETLQSKDF 173
+ +Y I E+EE +K++ ++ +E +C L K +R + +D
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDL 1432
Query: 174 KLEVEKLSKRIMALEKLEDAFNKS----KQECYSLKCNLEKERMTTKQLSQELESLKVRI 229
++E+ L+K + F+K KQ+ + LE + ++ LS EL ++
Sbjct: 1433 MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAY 1492
Query: 230 KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQ 289
+E+ L + L+E+++ LT + K + E +KT+ ++ S LQV
Sbjct: 1493 EEVVDQLETLRRENKNLQEEIS---DLTEQIAETGKNLQE-AEKTKKLVEQEKSDLQVAL 1548
Query: 290 NKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRV--NM 347
+V E + R + V+ ++ E+D+ +LK ++ + L V
Sbjct: 1549 EEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAE 1608
Query: 348 LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIED 407
+++R +L LK K+ D + L N ++ E + + ++ +LKD + D
Sbjct: 1609 IRSRNDALR------LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLD 1662
Query: 408 DLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLF----- 462
D +++ E L+ + A + L +ELE +K+ L + E+T EQ L
Sbjct: 1663 DALRSN---EDLKEQLAIVERRNGLLLEELEEMKVALEQ---TERTRRLSEQELLDASDR 1716
Query: 463 -KRLQEEEAKSGHLSREVDA--------LKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 513
+ L + + ++++A ++ I E E+ D +++ ++L ++
Sbjct: 1717 VQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKE 1776
Query: 514 ENRNRDLGREIENLTKELERYRH 536
++ + L R +NL + ++ +H
Sbjct: 1777 QDTSAHLERMKKNLEQTVKDLQH 1799
Score = 80.9 bits (198), Expect = 5e-15
Identities = 89/442 (20%), Positives = 195/442 (44%), Gaps = 39/442 (8%)
Query: 2 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTK 61
VVD+ + L + +++I +LT ET L AE + EQ+ + L+ L
Sbjct: 1495 VVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVAL------ 1548
Query: 62 FHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQID--------ELEETNRSLRKAEEELQD 113
+ + L +E+S+ ++Q +L+ + ++D E+E+ R+ ++A E LQ
Sbjct: 1549 -----EEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQS 1603
Query: 114 IKEKISKGEYGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKD 172
+ + + + ++E +L + + + + ++ + ++ R + +L+ L D
Sbjct: 1604 VLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDD 1663
Query: 173 FKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKEL 232
E L +++ +E+ + +E +K LE+ T + QEL R++ L
Sbjct: 1664 ALRSNEDLKEQLAIVERRNGLLLEELEE---MKVALEQTERTRRLSEQELLDASDRVQLL 1720
Query: 233 EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKV 292
+ + L T+ L+ D+ + + + E + EK KK + +L+ EQ+
Sbjct: 1721 HSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTS 1780
Query: 293 TTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKN 350
+ +K +E+T + L+ + D E++ LK +++ L +RV L+N
Sbjct: 1781 AHLERMKKNLEQTVKDLQHRLDEAEQL------------ALKGGKKQIQKLENRVRELEN 1828
Query: 351 RLQSLEAIEKDFLK--NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDD 408
L + + LK +K + + T +++ I L V++L+ K+K K ++
Sbjct: 1829 ELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEE 1888
Query: 409 LMKTEDEYETLERRYANERDKA 430
+ + + RR +E ++A
Sbjct: 1889 AEEQANTQLSRCRRVQHELEEA 1910
Score = 78.6 bits (192), Expect = 2e-14
Identities = 103/474 (21%), Positives = 206/474 (43%), Gaps = 76/474 (16%)
Query: 95 DELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK--- 151
++ E T L ++E ++++EK+ + +V+ + ++D E + E LIK
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917
Query: 152 -MEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK-LEDAFNKSKQECYSLKCNLE 209
+E + ++L +RLE E E+++ ++A ++ LED +C SLK +++
Sbjct: 918 LLEAKVKELTERLEEE-----------EEMNSELVAKKRNLED-------KCSSLKRDID 959
Query: 210 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 269
+T ++ +E + + ++K L + LE E+++KL E+K++ E
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTALE-------ENISKL-------TKEKKSLQE 1005
Query: 270 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 329
++T D LQVE++KV LI+ + + D+E + K R DL+
Sbjct: 1006 AHQQTLD-------DLQVEEDKVNG----LIKINAKLEQQTDDLEGSLEQEKKLRADLER 1054
Query: 330 -KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL 388
K K E + LK +S+ +E D K ++ + K L Q KI +
Sbjct: 1055 AKRKLEGD-----------LKMSQESIMDLEND--KQQIEEKLKKKEFELSQLQAKIDDE 1101
Query: 389 SQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL---- 444
+ + K+K+++A ++L + + TL + +R L++ELE + L
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSD---LARELEEISERLEEAS 1158
Query: 445 ----AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQ 500
A+ ++ +K E ++ R EEA H + K++ + I +LQ
Sbjct: 1159 GATSAQIEMNKKREAEFQKM---RRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 501 GDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQ 554
L+K+ ++ + D+ IE L+K +++ + + D Q
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Score = 76.6 bits (187), Expect = 9e-14
Identities = 104/528 (19%), Positives = 227/528 (42%), Gaps = 92/528 (17%)
Query: 18 QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT----------------- 60
Q++QE N + ++K A E Q + + L ++L+ T
Sbjct: 1399 QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLA 1458
Query: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLA----ALSRQIDELEETNRSLRKAEEELQDIKE 116
++ Q D A+L ++R L +L A +D+LE R + +EE+ D+ E
Sbjct: 1459 EWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTE 1518
Query: 117 KIS-------KGEYGNAGIMAEVEELRKRVLDMEG----KDEELIKMEEQCRDLNKRLER 165
+I+ + E + E +L+ + ++EG ++ ++++++ + + L+R
Sbjct: 1519 QIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDR 1578
Query: 166 ETLQSKDFKLEVEKLSKRIM-ALEKLEDAFNKSKQECYSLKCNLEKERMTTK-QLSQELE 223
+ ++ + ++++ S+R AL+ + DA +S+ + LK +E + + QL
Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNR 1638
Query: 224 SLKVRIKELEAIESRLEKTEF----------TLKEDLTKLKTLTVMFVDERKTMSEKLKK 273
+ K L ++ +L+ ++ LKE L ++ + ++E + M L++
Sbjct: 1639 QMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ 1698
Query: 274 T-------EDKLQAASSQLQV--EQNKVTTVTEKLIE--------ETKRALKSKTDVEEK 316
T E +L AS ++Q+ QN T+K +E E + +++ + EEK
Sbjct: 1699 TERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEK 1758
Query: 317 MYSVTKERDDLKNKLKAE--------------EEKGNDLLSRVNML--------KNRLQS 354
+ + +LK E E+ DL R++ K ++Q
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1818
Query: 355 LEAIEKDFLKNKLNQDSGKSTTAL---HQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 411
LE ++ L+N+L+ + + AL H+ K+KE++ + E K++ ++D + K
Sbjct: 1819 LENRVRE-LENELDVEQKRGAEALKGAHKYERKVKEMTYQAEE---DHKNILRLQDLVDK 1874
Query: 412 TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQ 459
+ + ++ +R+ ++A V+ EL + AE+ + + Q
Sbjct: 1875 LQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELE--EAAERADIAESQ 1920
Score = 75.5 bits (184), Expect = 2e-13
Identities = 117/588 (19%), Positives = 255/588 (43%), Gaps = 59/588 (10%)
Query: 6 QQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQD 65
+Q+L + + + +I ++ +N + + E + E + + ++ + + QT H D
Sbjct: 1218 KQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH-D 1276
Query: 66 QDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN 125
+ A+L +QN +L ++ I +L ++ ++L + EEL+ E+ +K +
Sbjct: 1277 LNMQKARL---QTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAM 1333
Query: 126 AGIMA----EVEELRKRVLD-MEGKDE---ELIKMEEQCRDLNKRLERETLQSKDFKLEV 177
A + + + LR++ + E K E L K + + E + +Q + E+
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE---EL 1390
Query: 178 EKLSKRI-MALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 236
E+ K++ L++ E+ + +C SL+ ++ + + L ++LE L+ +
Sbjct: 1391 EEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQ 1450
Query: 237 SRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV-------EQ 289
+K K+ L + + E +++S +L K + + QL+ Q
Sbjct: 1451 RNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQ 1510
Query: 290 NKVTTVTEKLIEETK---RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 346
+++ +TE++ E K A K+K VE++ + ++++ L+ EE K + ++
Sbjct: 1511 EEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELS 1570
Query: 347 MLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIE 406
+K+ L + IEKD +L ++S ++ AL + E+ + L+LK K +E
Sbjct: 1571 QVKSELDR-KVIEKDEEIEQLKRNSQRAAEALQSVLD--AEIRSRNDALRLK----KKME 1623
Query: 407 DDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQ 466
DL + E + R+ A + K L V+ +L +L + L ++L
Sbjct: 1624 GDLNEMEIQLGHSNRQMAETQ-------KHLRTVQGQLKDSQLHLDDALRSNEDLKEQLA 1676
Query: 467 EEEAKSGHLSREVDALKEKIHEYMATE--------DLICHLQGDHSVLQKKLNQQENRNR 518
E ++G L E++ +K + + T D +Q HS +N ++
Sbjct: 1677 IVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEA 1736
Query: 519 DLGR---EIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTE 563
D+ + E+EN +E +K + I+D + ++E++ E
Sbjct: 1737 DIAQCQAEVENSIQESRNAEEKAK--------KAITDAAMMAEELKKE 1776
Score = 68.9 bits (167), Expect = 2e-11
Identities = 81/350 (23%), Positives = 155/350 (44%), Gaps = 68/350 (19%)
Query: 282 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGND- 340
S++ + E + E+ EE R+ + ++EEKM S+ +E++DL+ ++++E E D
Sbjct: 846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905
Query: 341 -------------LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS---------------- 371
L ++V L RL+ E + + + K N +
Sbjct: 906 EERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTL 965
Query: 372 GKSTTALHQENNKIKELSQEV----ERLKLKLKDMKAIE-------DDLMKTEDEYETLE 420
K H NK+K LS+E+ E + K+ K+++ DDL ED+ L
Sbjct: 966 TKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLI 1025
Query: 421 RRYANERDKAQFLSKELEHVK-----MELAKYKLAEKTETSHE---------QWLFKRLQ 466
+ A + L LE K +E AK KL + S E Q + ++L+
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085
Query: 467 EEEAKSGHLSREVD-------ALKEKIHEYMA-TEDLICHLQGDHSVLQKKLNQQENRNR 518
++E + L ++D ++KI E A E+L ++ +H+ L+ K+ +Q +
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT-LRAKIEKQRS--- 1141
Query: 519 DLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 568
DL RE+E +++ LE + S + +N +R ++ Q ++++ + +E
Sbjct: 1142 DLARELEEISERLEE-ASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 106 bits (265), Expect = 8e-23
Identities = 124/598 (20%), Positives = 254/598 (42%), Gaps = 71/598 (11%)
Query: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE---KELQTQTTK 61
E ++T QL K+Q+ + + + L + + EQK LE K+L+ + +
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 62 FHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEE----TNRSLRKAEEELQDIKEK 117
++ + L + N L+ + LS+Q++ +E T L+K E L+ IK+K
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 118 ISKGEYG----------------------NAGIMAEVEELRKRVLDMEGK-------DEE 148
++K E N I V EL+K ++ E ++
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 149 LIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNL 208
L K+ + ++ E+E + K L++EK K + +L+ + +E LK +L
Sbjct: 862 LSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK--HQLQVQMENTLKEQKELKKSL 919
Query: 209 EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMS 268
EKE+ + QL EL S++ ++ + + + EK E L+ ++ +LK + + + +
Sbjct: 920 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 979
Query: 269 EKLK-----------KTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKM 317
+LK K + +L A+ +L E+ K++ + + + + ++D +
Sbjct: 980 GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
Query: 318 YSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTA 377
+ R DLK+ + DL+S N + N+ + ++ ++ K L QDS K
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT--AKATLEQDSAKKEQQ 1097
Query: 378 LHQENNKIKEL-------SQEVERLKLKLKDMKAI----EDDLMKTEDEYETLE----RR 422
L + ++++ +E+ K KL +++ I E ++ K +E ++ + +
Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKE 1157
Query: 423 YANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL--QEEEAKSGHLSREV- 479
N +D Q L ++ ++ + K A + E ++Q L ++ +EEE K + +E
Sbjct: 1158 ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAK 1217
Query: 480 --DALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 535
+KEK E+ L + L + L + + R + L K+ + R
Sbjct: 1218 LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Score = 105 bits (263), Expect = 1e-22
Identities = 112/564 (19%), Positives = 251/564 (44%), Gaps = 55/564 (9%)
Query: 8 RLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQD 67
RL Q L +K+ + + KL+ E +++E+ +T ELQ Q K Q
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNST----ELQHQLDKTKQQHQ 491
Query: 68 TIMAKLTNEDSQNRQLQQKLAALSRQIDE-----------LEETNRSLRKAEEELQDIKE 116
A + ++ R+ Q L + RQI + L+++ ++ E+E +D+
Sbjct: 492 EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYA 551
Query: 117 KISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 176
KI GE G ++ +++E + + + E K++ Q + E Q ++ K
Sbjct: 552 KIQAGE-GETAVLNQLQEKNHTLQEQVTQLTE--KLKNQSESHKQAQENLHDQVQEQKAH 608
Query: 177 VEKLSKRIMALE----KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI--- 229
+ R+++LE +L N+SK++ L +++ + T LS E R
Sbjct: 609 LRAAQDRVLSLETSVNELNSQLNESKEKVSQL--DIQIKAKTELLLSAEAAKTAQRADLQ 666
Query: 230 KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE-------------KLKKTED 276
L+ ++ L+ + L + T+L +T D+++ S+ L++ +
Sbjct: 667 NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726
Query: 277 KLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD---DLKNKLKA 333
+L+ +L+ + +V E+ +++ ++ + TD+E + ++K+ + ++ + +
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 334 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 393
+ +K ++ L + K +L E EK LK S ++ + NN+I+ E++
Sbjct: 787 DLQKKSEALESI---KQKLTKQEE-EKQILKQDFETLSQETKIQHEELNNRIQTTVTELQ 842
Query: 394 RLKLK----LKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKL 449
++K++ + ++ ++D L K D + + + E K + +LE EL
Sbjct: 843 KVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQ 902
Query: 450 AEKTETSHEQWLFKRLQEEEAKSGH-LSREVDALKEKIHEYMATEDLICHLQGDHSVLQK 508
+ T EQ K+ E+E ++ H L E+++++E++ + ++ + + + LQ
Sbjct: 903 VQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL---IQAQNTLKQNEKEEQQLQG 959
Query: 509 KLNQQENRNRDLGREIENLTKELE 532
+N+ + + ++IE L EL+
Sbjct: 960 NINELKQSSEQKKKQIEALQGELK 983
Score = 104 bits (259), Expect = 4e-22
Identities = 111/563 (19%), Positives = 248/563 (44%), Gaps = 41/563 (7%)
Query: 6 QQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQD 65
QQ TA+L + ++++ + K+ EA +Q+ ++ + LEKE + K
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAG 556
Query: 66 QDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSLRKAEEE 110
+ A L +N LQ+++ L+ ++ D+++E LR A++
Sbjct: 557 EGET-AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 111 LQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEE----QCRDLNKRLERE 166
+ ++ +++ N+ + E++ + + ++ K E L+ E Q DL L+
Sbjct: 616 VLSLETSVNEL---NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
Query: 167 TLQSKDFKLEVEKLSKRI-MALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 225
+D + E+ K++ ++ KL+D ++ C L+ +L++ + L Q+ E L
Sbjct: 673 QNALQDKQQELNKITTQLDQVTAKLQD----KQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 226 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 285
+ +IK+LEA ++ ++ +DL + + L +S++L+ ++ + + L
Sbjct: 729 EGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDL 788
Query: 286 QVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRV 345
Q + + ++ +KL ++ + K D E + ++L N+++ + L +V
Sbjct: 789 QKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE----LQKV 844
Query: 346 NMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAI 405
M K L + + KD L +K++ S + +EN K K ++E+ +LK +
Sbjct: 845 KMEKEALMTELSTVKDKL-SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903
Query: 406 EDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 465
+ + T E + L++ E++ + L EL ++ +L + + K EQ L +
Sbjct: 904 Q--MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Query: 466 QEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIE 525
E + S ++++AL+ ++ + + + + LQ++L Q +I
Sbjct: 962 NELKQSSEQKKKQIEALQGELKIAVLQKTEL------ENKLQQQLTQAAQELAAEKEKIS 1015
Query: 526 NLTKELERYRHFSKSLRPSLNGR 548
L E+ + K L+ GR
Sbjct: 1016 VLQNNYEKSQETFKQLQSDFYGR 1038
Score = 95.5 bits (236), Expect = 2e-19
Identities = 126/602 (20%), Positives = 253/602 (42%), Gaps = 73/602 (12%)
Query: 13 LTLQRQKIQELTTNAKE-----THTKLALAEAR-VQEEEQKATRLEKELQTQTTKFHQDQ 66
+TL RQ++Q+L + KE K L + + +Q++E K L + + Q
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 67 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELE---ETNRSLRK-AEEELQDIKEKISKGE 122
+ + N +QK A L+ +I +++ + RSLR+ AE+++ + E+++K
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 123 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK 182
+ E+ + R + D+ +EL++++ ++ ERE+ + KD
Sbjct: 205 TVIQDLKTELLQ-RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD---------- 253
Query: 183 RIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT 242
+KL+ + S+ L+ L K QEL+ LK + EL L +
Sbjct: 254 ---ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 243 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 302
++D TKL+ +K + L + + Q S+L + + + +L E+
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 303 ---TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIE 359
T++ + ++VE K + E L+ + + +E+ G L S +N L ++L E
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE--- 427
Query: 360 KDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL 419
+L + G+ + K+ + Q+V L+LKL ++ E L
Sbjct: 428 -----RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE-------------EQL 469
Query: 420 ERRYANERDKAQFLSK-ELEHVKMELAKYKLAEKTETSHE--QWLFKRLQEEEAKSGHLS 476
+ + N + L K + +H + + + K + + + +++ +++ K +L
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 529
Query: 477 REVDALKEKIHEY-MATEDLICHLQ---GDHSVLQKKLNQQENRNRDLGREIENLTKELE 532
+ KE I EDL +Q G+ +V LNQ + +N L ++ LT++L+
Sbjct: 530 ALLQKSKENISLLEKEREDLYAKIQAGEGETAV----LNQLQEKNHTLQEQVTQLTEKLK 585
Query: 533 RYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAV--INGQLYEE 590
K + +L+ QV ++ A + ++ LE +V +N QL E
Sbjct: 586 NQSESHKQAQENLH------DQVQEQKAHLRAAQDR------VLSLETSVNELNSQLNES 633
Query: 591 SE 592
E
Sbjct: 634 KE 635
Score = 91.3 bits (225), Expect = 4e-18
Identities = 152/778 (19%), Positives = 325/778 (41%), Gaps = 77/778 (9%)
Query: 12 QLTLQRQKI--QELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTI 69
Q TL ++ + Q+L + + T L + E+ + +L++EL TK+ +
Sbjct: 336 QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQH----L 391
Query: 70 MAKLTNEDSQNRQLQQKLAALSRQIDELE----ETNRSLRKA----EEELQDIKEKISKG 121
A+ Q + +Q L +I++L ET R L +A +E+ Q EK+
Sbjct: 392 KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK 451
Query: 122 EYGNAGIMAEV----EELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEV 177
E A + ++ E+L+++V + +L K ++Q ++ + T + ++ + ++
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511
Query: 178 EKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE---A 234
E++ ++I Q+ +L+ L+K + L +E E L +I+ E A
Sbjct: 512 EQVLRQI----------GDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 235 IESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTT 294
+ ++L++ TL+E +T+ LT ++ ++ + + D++Q + L+ Q++V +
Sbjct: 562 VLNQLQEKNHTLQEQVTQ---LTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618
Query: 295 VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 354
+ + E + +SK V + + + + L + A+ + DL + ++ +N LQ
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 355 LEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDL-MKTE 413
+ Q+ K TT L Q K+++ + +L+ LK+ K L KTE
Sbjct: 679 KQ------------QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTE 726
Query: 414 D--------EYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 465
+ E ++LE + + E+ + + +EL +L+++ E E RL
Sbjct: 727 ELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 786
Query: 466 QEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIE 525
++ S ++++K+K+ + + + L+ D L ++ Q + +L I+
Sbjct: 787 DLQKK-----SEALESIKQKLTKQEEEKQI---LKQDFETLSQETKIQ---HEELNNRIQ 835
Query: 526 NLTKELERYRHFSKSLRPSLN--GRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVI 583
EL++ + ++L L+ ++S K ++E +++ LE+
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC- 894
Query: 584 NGQLYEESENQDEDPNDEGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPN 643
+L + + Q E+ E L + KL + M+ + QN Q +
Sbjct: 895 -KELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 644 ANFVQPGDLVLSHTPGQPLHIKVTPDHVQNTATLEITSPT-TESPHSYTSTAVIPNCGTP 702
+Q L + Q K + +Q + + T E+ T
Sbjct: 954 EQQLQGNINELKQSSEQK---KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
Query: 703 KQRITILQNASITPVKSKTSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMS 760
K++I++LQN KS+ + + L + G +AT ++ E SL E +S
Sbjct: 1011 KEKISVLQN---NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Score = 86.3 bits (212), Expect = 1e-16
Identities = 107/522 (20%), Positives = 228/522 (43%), Gaps = 35/522 (6%)
Query: 15 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 74
L QK +L T + +K + + EQK TRL +EL + T + ++ +
Sbjct: 160 LFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPG 219
Query: 75 NEDSQNRQLQQKLAALSRQIDELE-ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVE 133
ED L+++L + +D + E R K ++E + ++ + + E A I
Sbjct: 220 IEDVA--VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSE---ATISQLRS 274
Query: 134 ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA 193
EL K ++ +EL K++ +L ++ + T E L K+ KLE+
Sbjct: 275 ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT----------ENLLKKEQDYTKLEEK 324
Query: 194 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKL 253
N+ +++ L ++ + +QL L + + + + S + LKE+L+++
Sbjct: 325 HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV 384
Query: 254 KTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 313
+T E K + ++ ++ E S++ +K+ +L E R + +
Sbjct: 385 ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 444
Query: 314 EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK 373
EK+ ++ DL+ KL EE+ + ++ L+++L +K +++ Q +
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL------DKTKQQHQEQQALQQ 498
Query: 374 STTA-LHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQF 432
STTA L + N ++++ +++ K+++++A+ L K+++ LE+ + K Q
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL---LQKSKENISLLEKEREDLYAKIQA 555
Query: 433 LSKELEHVKMELAKYKLAEKTETSHEQ--WLFKRLQEEEAKSGHLSREV-DALKEKIHEY 489
E + +L EK T EQ L ++L+ + + D ++E+
Sbjct: 556 GEGETAVLN------QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 609
Query: 490 MATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
A +D + L+ + L +LN+ + + L +I+ T+ L
Sbjct: 610 RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL 651
Score = 83.2 bits (204), Expect = 1e-15
Identities = 104/522 (19%), Positives = 226/522 (43%), Gaps = 69/522 (13%)
Query: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTKLAL----AEARVQEEEQKATRLEKELQTQTT 60
E++ L +L+ + K+ +++ + K + ++ +A + + E+ L+ +LQ Q
Sbjct: 847 EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQME 906
Query: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
++Q + L E + QL+ +L ++ Q+ + + T + K E++LQ
Sbjct: 907 NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ-------- 958
Query: 121 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQS-KDFKLEVEK 179
GN + + E +K+ +E EL Q +L +L+++ Q+ ++ E EK
Sbjct: 959 ---GNINELKQSSEQKKK--QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
Query: 180 LSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE--------------SL 225
+S EK ++ F + + + Y + L R K + ++L +
Sbjct: 1014 ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQ 1073
Query: 226 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 285
I+EL+ ++ LE+ + KE + + + + + K++ EK E A ++
Sbjct: 1074 NKLIQELKTAKATLEQ-DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEI 1132
Query: 286 QVEQNK-VTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK---LKA--EEEKGN 339
+ Q K +T + E+L ++K T++++ + +++ +L+ K LKA E+EK N
Sbjct: 1133 KCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 340 DLLSRVNMLKNRLQSLEAIEKDFLKN----------------KLNQDSGKSTTALHQENN 383
+ + + K E ++K+F++ K ++ K T + N
Sbjct: 1193 QQILKDQVKKEE----EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE 1248
Query: 384 KIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKME 443
+ + +E + + ++ +++ DDL E LE N +D+ + L + + E
Sbjct: 1249 NLGTVKKEWQSSQRRVSELEKQTDDL---RGEIAVLEATVQNNQDERRALLERCLKGEGE 1305
Query: 444 LAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 485
+ EK +T + L ++L A L RE +L+ K
Sbjct: 1306 I------EKLQTKVLE-LQRKLDNTTAAVQELGRENQSLQIK 1340
Score = 70.9 bits (172), Expect = 5e-12
Identities = 92/452 (20%), Positives = 184/452 (40%), Gaps = 79/452 (17%)
Query: 145 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK--------------LSKRIMALEKL 190
K +++ + ++ +DL L+ E S++ K E+EK ++ L+ L
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSL 140
Query: 191 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE---------- 240
E +++ E +++K + QL+ E+ +K + E ++ E
Sbjct: 141 EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200
Query: 241 ----------KTEF----------TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ- 279
KTE LK++L +++TL ER+ SEKLK KLQ
Sbjct: 201 NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260
Query: 280 ------AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT-----KERDDLK 328
A SQL+ E K ++E ++ S ++ +K ++T KE+D
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD--- 317
Query: 329 NKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL 388
K EE+ + +S+ N+ Q KD +L S T+LH+ + ++ E
Sbjct: 318 -YTKLEEKHNEESVSKKNIQATLHQ------KDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 389 SQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL---- 444
+ ++LK +++ +E + E++ L+++ + L E+ + +L
Sbjct: 371 GEATQKLK---EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 445 -----AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHL 499
A +L E+ + S E+ + K Q + + LSR + LKEK+ + +
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL-KLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 500 QGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
+ H Q + R+ ++E + +++
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518
Score = 60.5 bits (145), Expect = 7e-09
Identities = 90/418 (21%), Positives = 181/418 (43%), Gaps = 68/418 (16%)
Query: 188 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE----LEAIESRLEKTE 243
E + DA N S + + NL +R L QE++ L+ +KE E ++ LEK +
Sbjct: 61 EAVHDAGNDSG---HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
Query: 244 FTLKEDL----------TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVT 293
+++ +L++L ++E +T + +K+ +D + ++QL E +
Sbjct: 118 GLQQQEAKPDGLVTDSSAELQSLEQQ-LEEAQTENFNIKQMKDLFEQKAAQLATE---IA 173
Query: 294 TVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSR-----VNML 348
+ K EE R+L+ E VT+ ++L + ++ +LL R V +L
Sbjct: 174 DIKSKYDEE--RSLR-----EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
Query: 349 KNRLQSLEAI----------EKDFLKN---KLNQDSGKSTTALHQENNKIKELSQEV--- 392
K L ++ + E + LK+ KL S + Q +++ + QEV
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 393 ----ERLKLKLKDM----KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL 444
++LK + ++ + + ++L+K E +Y LE ++ E + + L ++
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 445 AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHS 504
+ ++ S + R+ E ++ G +++ LKE++ E E HL+ +
Sbjct: 347 QQL----QSRLSASETSLHRIHVELSEKGEATQK---LKEELSE---VETKYQHLKAEFK 396
Query: 505 VLQKKLNQQENRNRDLGREIENL-TKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQ 561
LQ++ ++E L EI L +K LE R ++ R++S ++ KE Q
Sbjct: 397 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 105 bits (263), Expect = 1e-22
Identities = 108/542 (19%), Positives = 254/542 (46%), Gaps = 63/542 (11%)
Query: 47 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 106
K+ EKE+ T +F + ++T L +++ ++L++K+ +L ++ ++L+ ++
Sbjct: 843 KSAETEKEMATMKEEFGRIKET----LEKSEARRKELEEKMVSLLQEKNDLQ---LQVQA 895
Query: 107 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 161
++ L D +E+ + + A+V+E+ +R+ D E + EL K+E++C +L K
Sbjct: 896 EQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKD 955
Query: 162 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 207
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 956 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE 1015
Query: 208 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 264
+K +K +L Q+++ L+ +++ + + LE+ + L+ DL + + +++
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075
Query: 265 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYS---VT 321
+ EKLKK E + +S+++ EQ + +KL E R + + ++E + + V
Sbjct: 1076 LQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVE 1135
Query: 322 KERDDLKNKL----KAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS------ 371
K R DL +L + EE G ++ M K R + + +D + L ++
Sbjct: 1136 KLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1195
Query: 372 ---GKSTTALHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETLERRYA 424
S L ++ + ++ + Q++E+ KL+L D+ + + ++K + E + R
Sbjct: 1196 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLE 1255
Query: 425 NERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR------- 477
++ ++ + +E + + + +TE L ++L+E+EA L+R
Sbjct: 1256 DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE---LARQLEEKEALISQLTRGKLSYTQ 1312
Query: 478 EVDALKEKIHEYMATEDLICH----LQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 533
+++ LK ++ E ++ + H + D +L+++ ++ +L R + E+ +
Sbjct: 1313 QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1372
Query: 534 YR 535
+R
Sbjct: 1373 WR 1374
Score = 91.3 bits (225), Expect = 4e-18
Identities = 118/592 (19%), Positives = 248/592 (41%), Gaps = 77/592 (13%)
Query: 18 QKIQELTTNAKETHTKLALAEARVQEEEQ---KATRLEKELQTQTTKFHQDQDTIMAKLT 74
++ +L N + K+ R+++EE+ + T +++L+ + ++ +D D + L
Sbjct: 905 ERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLA 964
Query: 75 NEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEE 134
+ + + K+ L+ ++ L+E L K ++ LQ+ ++ +++
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQ-------------ALDD 1011
Query: 135 LRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL-------SKRIMAL 187
L+ + + +K+E+Q DL LE+E D + KL + IM L
Sbjct: 1012 LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071
Query: 188 E----KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------AIE 236
E +LE+ K + + +E E++ QL ++L+ + RI+ELE
Sbjct: 1072 ENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTAR 1131
Query: 237 SRLEKTEFTLKEDLTKLKT-------LTVMFVDERKTMSEKLKKTEDKLQAASSQLQVE- 288
+++EK L +L ++ T + ++ K + +K L+ A+ Q +
Sbjct: 1132 AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATA 1191
Query: 289 ---QNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN------KLKAEEEK-G 338
+ K +L E+ + K +E++ E DD+ + K KA EK
Sbjct: 1192 AALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVS 1251
Query: 339 NDLLSRVNMLKNRLQSLEAIEKDFL--KNKLNQDSGKSTTALHQENNKIKEL-------S 389
L + N + +L+ + DF + KL ++G+ L ++ I +L +
Sbjct: 1252 RTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYT 1311
Query: 390 QEVERLKLKL----KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELA 445
Q++E LK +L K A+ L + + L +Y E + L + L E+A
Sbjct: 1312 QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371
Query: 446 KYKLAEKTET--------SHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYM-ATEDLI 496
+++ +T+ ++ L +RLQ+ E ++ + +L++ H EDL+
Sbjct: 1372 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431
Query: 497 CHLQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERYRHFSKSLRPSL 545
++ ++ +Q N ++ L ++ E ELE + ++SL L
Sbjct: 1432 VDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483
Score = 72.8 bits (177), Expect = 1e-12
Identities = 100/488 (20%), Positives = 207/488 (42%), Gaps = 62/488 (12%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
+E LT QL + + EL K+ + ++ ++E E E ++ +F+
Sbjct: 1509 EEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFN 1568
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
Q + I KL +D + Q ++ R +D L+ + + ++ E+ +K+K+
Sbjct: 1569 QIKAEIERKLAEKDEEMEQAKRNH---QRVVDSLQTSLDAETRSRNEVLRVKKKME---- 1621
Query: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKR 183
G + E+E + + + + ++Q + L L+ +Q D + L +
Sbjct: 1622 ---GDLNEME------IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN 1672
Query: 184 IMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE 243
I +E+ + +E L+ +E+ + K QEL R++ L + + L +
Sbjct: 1673 IAIVERRNNLLQAELEE---LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729
Query: 244 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTV--TEKLIE 301
++ DLT+L++ V E + EK KK + +L+ EQ+ + +K +E
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789
Query: 302 ETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKD 361
+T + L+ + D E++ LK +++ L +RV L+ L++
Sbjct: 1790 QTIKDLQHRLDEAEQI------------ALKGGKKQLQKLEARVRELEGELEA------- 1830
Query: 362 FLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLER 421
+ K N +S K + + +IKEL+ + E K L ++ + D L Y +
Sbjct: 1831 --EQKRNAESVK---GMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAY----K 1881
Query: 422 RYANERDKAQFLSKELEHVKMELAKY-KLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 480
R A E + E L+K+ K+ + + + E+ Q + ++ SR++
Sbjct: 1882 RQAEEAE---------EQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA--KSRDIG 1930
Query: 481 ALKEKIHE 488
A K+K+H+
Sbjct: 1931 A-KQKMHD 1937
Score = 65.5 bits (158), Expect = 2e-10
Identities = 96/465 (20%), Positives = 206/465 (44%), Gaps = 67/465 (14%)
Query: 126 AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE-RETLQSKDFKLEVE------ 178
AG++ +EE+R L + +M+ Q R R+E ++ ++ +D L ++
Sbjct: 769 AGLLGLLEEMRDERLS-----RIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAF 823
Query: 179 ---------KLSKRIMALEK---LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 226
KL +I L K E K+E +K LEK K+L +++ SL
Sbjct: 824 MGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSL- 882
Query: 227 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 286
++E ++ +++ + L + + L + + + K+K+ ++L+ +
Sbjct: 883 --LQEKNDLQLQVQAEQDNLNDAEERCDQL----IKNKIQLEAKVKEMNERLED-----E 931
Query: 287 VEQN-KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK--AEEEKGNDLLS 343
E N ++T KL +E K D+E + V KE+ +NK+K EE G D
Sbjct: 932 EEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD--- 988
Query: 344 RVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMK 403
+ + + K+ K L + ++ L E +K+ LS+ +L+ ++ D++
Sbjct: 989 ---------EIIAKLTKE--KKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLE 1037
Query: 404 AIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK 463
+ K + E +R+ + Q +LE+ K++L + KL +K ++Q
Sbjct: 1038 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE-KLKKKEFDINQQ--NS 1094
Query: 464 RLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 523
++++E+ + L +++ + +I E+L L+ + + K E DL RE
Sbjct: 1095 KIEDEQVLALQLQKKLKENQARI------EELEEELEAERTARAK----VEKLRSDLSRE 1144
Query: 524 IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 568
+E +++ LE + S++ +N +R ++ Q ++++ + +E
Sbjct: 1145 LEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1188
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 103 bits (258), Expect = 5e-22
Identities = 129/563 (22%), Positives = 246/563 (43%), Gaps = 83/563 (14%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL-------- 55
+E QR QL ++K Q LT ++T L + R E E+K R + EL
Sbjct: 1419 EESQRALQQL---KKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ 1475
Query: 56 --QTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQD 113
+ Q K +++D ++A+ + Q + +A ++++ LE ELQD
Sbjct: 1476 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEA----------ELQD 1525
Query: 114 IKEKISKGEYGNAGIMAEVEELRKRVLDMEGK----DEEL------IKMEEQCRDLNKRL 163
I + SK E A + +++K++ D+E K +EEL I+M EQ + L +
Sbjct: 1526 ISSQESKDE-------ASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAK-LRLEM 1577
Query: 164 ERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE 223
E E ++ K E+E E++E+A +++ ++ LE+E +++ +E
Sbjct: 1578 EMERMRQTHSK-EMESRD------EEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKR 1630
Query: 224 SLKVRIKEL-EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAAS 282
L+ ++ L + + R ++E L++DL + K L D + + K + A
Sbjct: 1631 ELEGKLATLSDQVNRRDFESEKRLRKDLKRTKAL---LADAQLMLDHLKNSAPSKREIAQ 1687
Query: 283 SQLQVEQNKVTTVT------------EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK 330
+ Q+E+++ T E L + K+KT +EE++ + +E+++++N+
Sbjct: 1688 LKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNR 1747
Query: 331 LKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQ 390
L+ ++E N+L M K++ +A N L ++ + K++ L
Sbjct: 1748 LEEDQEDMNEL-----MKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQS 1802
Query: 391 EVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDK-------AQFLSKELEHVKME 443
+VE L+ + D + + E + LE R ER + A L + +E + E
Sbjct: 1803 QVEFLEQSMVDKSLVS----RQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEE 1858
Query: 444 LAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDH 503
+ AE E + L ++L++ + + G L+R+ K HE E + L+ +
Sbjct: 1859 RDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE---LEMDLESLEAAN 1915
Query: 504 SVLQKKLNQQENRNRDLGREIEN 526
LQ L R DL IE+
Sbjct: 1916 QSLQADLKLAFKRIGDLQAAIED 1938
Score = 90.5 bits (223), Expect = 6e-18
Identities = 120/624 (19%), Positives = 267/624 (42%), Gaps = 109/624 (17%)
Query: 12 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT--- 68
++ L ++I+ ++ +KL AE E + RLE + T++ +++T
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGES 1307
Query: 69 -------IMAKLTNEDSQNRQLQQKLAALSRQID--ELEETNRSLRKAEEELQDIKEKIS 119
A+ + + ++LQ + AL +Q++ E+E L +A E ++ + +
Sbjct: 1308 ASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDA 1367
Query: 120 KGEYGNAGIMA-------------------EVEELRKRVLDMEGKDEELIKMEEQ--CRD 158
GE+ A EVE+ KR L+ D + E Q +
Sbjct: 1368 GGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQ 1427
Query: 159 LNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQ------------------- 199
L K+ +R T + +D KL +E R LEK + F+
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1487
Query: 200 ------ECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKL 253
E +SLK LE++ M +Q++ SL+ ++++ + ES+ E + +K+ L L
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDL 1547
Query: 254 KTL-------------TVMFVDE------------RKTMSEKLKKTEDKLQAASSQLQVE 288
+ T+ +++ R+T S++++ +++++ A Q +
Sbjct: 1548 EAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKK 1607
Query: 289 QNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKE---RD-DLKNKLKAEEEKGNDLLSR 344
++ E+ E+ ++ L+ K ++E K+ +++ + RD + + +L+ + ++ LL+
Sbjct: 1608 LKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLAD 1667
Query: 345 VNMLKNRLQSLEAIEKDF--LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDM 402
++ + L++ +++ LKN+L + A+ K + E+E L L++
Sbjct: 1668 AQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR----KAMEVEIEDLHLQI--- 1720
Query: 403 KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLF 462
DD+ K + E R E+++ Q +E + EL K A + S +
Sbjct: 1721 ----DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD---L 1773
Query: 463 KRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL-NQQENRNRDLG 521
++ + +A+ ++E L+EK+ + + + + S++ K L ++QE + R+L
Sbjct: 1774 AQINDLQAQLEEANKEKQELQEKLQALQSQVEFL-----EQSMVDKSLVSRQEAKIRELE 1828
Query: 522 REIENLTKELERYRHFSKSLRPSL 545
+E +++R + L+ ++
Sbjct: 1829 TRLEFERTQVKRLESLASRLKENM 1852
Score = 76.6 bits (187), Expect = 9e-14
Identities = 81/440 (18%), Positives = 197/440 (44%), Gaps = 46/440 (10%)
Query: 3 VDEQQRLTAQLTLQRQKIQELTTNAKETHTK-LALAEARVQEEEQKATRLEKELQTQTTK 61
+DEQ L + +++ ++TH+K + + V+E Q + K+++ Q +
Sbjct: 1558 LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 62 FHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE-ETNRSLRK-------------- 106
++D+ ++ + R+L+ KLA LS Q++ + E+ + LRK
Sbjct: 1618 EYEDKQKVLR-------EKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQL 1670
Query: 107 ----------AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 156
++ E+ +K ++ + E+ A + + + + D+ + +++ K +
Sbjct: 1671 MLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTAL 1730
Query: 157 RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA-FNKSKQECYSLKCNLEKERMTT 215
+ RL+RE + ++ E ++ +M K A ++ + L+ LE+
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEK 1790
Query: 216 KQLSQELESLKVRIKELEAI---ESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK 272
++L ++L++L+ +++ LE +S + + E ++E T+L+ V ++++ +LK
Sbjct: 1791 QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQ-VKRLESLASRLK 1849
Query: 273 KTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 332
+ +KL Q +N+ ++L + + + ++ K ++++ +L+ L+
Sbjct: 1850 ENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLE 1909
Query: 333 AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV 392
+ E L + + + R+ L+A +D +++ N+D S +++ EL V
Sbjct: 1910 SLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINS----EGDSDVDSELEDRV 1965
Query: 393 ERLKLKLK----DMKAIEDD 408
+ +K L KA DD
Sbjct: 1966 DGVKSWLSKNKGPSKAASDD 1985
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 103 bits (256), Expect = 9e-22
Identities = 130/582 (22%), Positives = 264/582 (45%), Gaps = 76/582 (13%)
Query: 23 LTTNAKETHTKLALAE-------ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTN 75
L + KET +KL+ E ++ ++K R E EL+ + ++ + + K+TN
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKITN 650
Query: 76 -------------EDSQ----NRQLQQ----------KLAALSRQIDELEETNRSLRKAE 108
E+S+ NR+L++ +L +L ++ +L+E N LR+
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 109 EELQDIKEKISKGEYGNAGIMAEVEELRK--RVLDMEGKDEELIKMEEQCRDLNKRLERE 166
E L+ K+++ + N + +E E+L+K +L K E +++ Q D+ + ++
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK 770
Query: 167 TLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 226
TL++ + K +++L + LE K+ +E LE+ K L QE L+
Sbjct: 771 TLENSNKK--IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 227 VRIKELEAIESRL----EKTEFTLKEDLTKLKTLTVMFVDERKTMSE----------KLK 272
K+LE RL E + TL+E+ K+ L E KT+S+ +LK
Sbjct: 829 KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE----KENKTLSKEIGIYKESCVRLK 884
Query: 273 KTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 332
+ E + + + ++ + T+ E L+ E + + D+E+ + + K + K +L
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN-KERLL 943
Query: 333 AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV 392
+E+ +D SR +L+++L+S + + K+ L + N ++L QE+
Sbjct: 944 HDEQSTDD--SRYKLLESKLESTLKKSLEIKEEKI----AALEARLEESTNYNQQLRQEL 997
Query: 393 ERLKLKLKDMKAIEDD--LMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLA 450
+ +K + +K +D+ ++++ + ++ E +Q ++EL VK L + +
Sbjct: 998 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE---SQETTRELLKVKDRLIEVERN 1054
Query: 451 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK---IHEYMAT-EDLICHLQGDHSVL 506
T + +Q L +L++ E ++ +L ++ AL+ + + E T + LQ ++S L
Sbjct: 1055 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL 1114
Query: 507 QKKLNQQENRNRDL---GREIENLTKELERYRHFSKSLRPSL 545
+ N+N L +EN + + + R KSL SL
Sbjct: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
Score = 101 bits (252), Expect = 3e-21
Identities = 145/616 (23%), Positives = 260/616 (42%), Gaps = 71/616 (11%)
Query: 17 RQKIQELTTNAK---ETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH-----QDQDT 68
+ +++EL + + ET T L + K LEKE K H +D D
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 69 IMAKLTNEDSQNRQLQQK------------LAALSRQIDELEETNRSLRKAEEELQDIKE 116
+ E++ ++ QK L +SR + E +SL EL
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS--S 460
Query: 117 KISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKR---LERETLQSKDF 173
++ K E N + VEELR V +EG +++KME++ + L+K+ LE E +Q K
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 174 KLEVEKLSKRIM----ALEK-LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-SLKV 227
+ LSK +M LEK +E S+++ L+ E T L Q + S +
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 228 RIKELEAIESRLEKTEFTLKEDLTKL---KTLTVMFVDERKTMSEKLKKTEDKLQAASSQ 284
R+K++E L ++ L+K+ K ++ K E+ ++ E++L +
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 285 LQVEQNKVTTVTEKLIEETKRALKSK-TDVEEKMYSVTKERDDLKNKLKAEE--EKGNDL 341
++ Q K+T + K+ E AL+ + +++E + + K D KN E EK N
Sbjct: 641 NELLQKKITNL--KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
Query: 342 LSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLK 400
L N+ L+ ++SL+ + +L +S + ++L + +E LK K
Sbjct: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELES---------EKEQLKKGLELLKASFK 749
Query: 401 DMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKME-LAKYKLAEKTETSHEQ 459
+ +E + E + L++ N K Q L EL+ ++ME K E+ + S
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS-- 807
Query: 460 WLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRD 519
KRL++ E ++ L +E L EK + + E+ L+ + L + + +
Sbjct: 808 ---KRLEQLEKENKSLEQETSQL-EKDKKQLEKENK--RLRQQAEIKDTTLEENNVKIGN 861
Query: 520 LGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLE 579
L +E + L+KE+ Y+ L+ KE E V D K+L+ L
Sbjct: 862 LEKENKTLSKEIGIYKESCVRLKE------------LEKE-NKELVKRATIDIKTLVTLR 908
Query: 580 RAVINGQLYEESENQD 595
+++ +L + N D
Sbjct: 909 EDLVSEKLKTQQMNND 924
Score = 100 bits (250), Expect = 5e-21
Identities = 130/597 (21%), Positives = 263/597 (44%), Gaps = 89/597 (14%)
Query: 2 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTK 61
+V E+Q L L + ++E K T +E +++ EQ+ L QT ++
Sbjct: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN---QTVSSL 570
Query: 62 FHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 121
+ Q + A++ + + +N+ L + + S ++ ++E R ++K E ++ E+ +
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 122 EYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLS 181
E + E E L+K++ +++ E++ +E++ N LERE + K + L+
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQE----NSELERENRKLKKTLDSFKNLT 686
Query: 182 KRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES 237
++ +LEK L++ + ++ SLKC S ++ L++ KELE+ +
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKC-----------ASMKMAQLQLENKELESEKE 735
Query: 238 RLEKTEFTLKEDLTKLKTLTVMFVD---ERKTMSEKLKKTEDKLQAASSQLQ-------- 286
+L+K LK K + L V + E + + + L+ + K+Q S+LQ
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 287 ----VEQNKVTTVTEKLIEETKRALKSKT-DVEEKMYSVTKERDDLKNKLKAEE------ 335
+E+ K+++ + +E+ ++L+ +T +E+ + KE L+ + + ++
Sbjct: 796 LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Query: 336 -------EKGNDLLSR-VNMLKN---RLQSLEAIEKDFLKN---------KLNQDSGKST 375
EK N LS+ + + K RL+ LE K+ +K L +D
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK 915
Query: 376 TALHQENNKIKELSQEVERLKLK----LKDMKAIEDDLMK----------------TEDE 415
Q NN +++L+ E+E++ L L D ++ +D K E++
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEK 975
Query: 416 YETLERRYANERDKAQFLSKELEHVK--MELAKYKLAEKTETSHEQWLFKRLQEEEAKSG 473
LE R + Q L +EL+ VK E K + E+ + + E +S
Sbjct: 976 IAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQ 1035
Query: 474 HLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKE 530
+RE+ +K+++ E E LQ + L+ +L Q E +N +L +I L ++
Sbjct: 1036 ETTRELLKVKDRLIE---VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Score = 98.6 bits (244), Expect = 2e-20
Identities = 150/620 (24%), Positives = 279/620 (45%), Gaps = 85/620 (13%)
Query: 31 HTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAAL 90
H + LA+A+ K RL +EL+ +T + L + + Q++ +L L
Sbjct: 248 HLSVELADAKA-----KIRRLRQELEEKTEQ-----------LLDCKQELEQMEIELKRL 291
Query: 91 SRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGI------MAEVEELRKRVLDMEG 144
++ L RS R +EL ++EK + + + + + ++E + RV +++
Sbjct: 292 QQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
Query: 145 KDEELIK----MEEQCRDLNKR------LERETLQSK----DFKLEVEKLSKRIMALEK- 189
++ L++ +E+Q R LE+E LQ K D ++E + K+I L +
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411
Query: 190 ---LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL 246
LE A +S E L LE+ T++ +SL + EL + SRL K E
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS--SRLLKLEME- 468
Query: 247 KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL---IEET 303
+ LTK VD + + K+ K E + Q S ++++ +N++ + L +
Sbjct: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS 528
Query: 304 KRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ-SLEAIEKDF 362
K +K K +E+ + ++ R++ + ++K E++ L V+ L+ R Q S EA KD
Sbjct: 529 KDLMKEKAQLEKTIETL---RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
Query: 363 LK-NKLNQDSGKSTTA-LHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
K NK+ +S K T++ L + + +++ +E+E K K + + +E++L E E E L+
Sbjct: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
Query: 421 RRYANER---DKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR 477
++ N + +K + L +E ++ E K K KT S + F +L+ E ++ L
Sbjct: 646 KKITNLKITCEKIEALEQENSELERENRKLK---KTLDSFKNLTF-QLESLEKENSQLDE 701
Query: 478 EVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR-H 536
E L+ + E L C K+ Q + N++L E E L K LE +
Sbjct: 702 ENLELRRNV------ESLKC--------ASMKMAQLQLENKELESEKEQLKKGLELLKAS 747
Query: 537 FSKS--LRPSLNGRRISDPQVFS---------KEVQTEAVDNEPPDYKSLIPLERAVING 585
F K+ L S G I + ++ +++++E D E + LE I+
Sbjct: 748 FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISS 807
Query: 586 QLYEESENQDEDPNDEGSVL 605
+ E+ E +++ E S L
Sbjct: 808 KRLEQLEKENKSLEQETSQL 827
Score = 97.8 bits (242), Expect = 4e-20
Identities = 133/600 (22%), Positives = 260/600 (43%), Gaps = 79/600 (13%)
Query: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQ 64
E Q LT + R + + NA +K+ E Q +K LE E+ Q + Q
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNA----SKILKMEKENQRLSKKVEILENEI-VQEKQSLQ 522
Query: 65 DQDTIMAKLTNEDSQNRQLQQKLAALS-RQIDELEETNRSLRKAEEELQDIKEKISKGEY 123
+ + L E +Q + + L S RQI LE+ N L + L+
Sbjct: 523 NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ---------- 572
Query: 124 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKR 183
+ I AE RV D+E +++ L E ++ + +L + + + K E+E ++
Sbjct: 573 -RSQISAEA-----RVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
Query: 184 IMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE---SRLE 240
E+LE+ + +LEKE + L +++ +LK+ +++EA+E S LE
Sbjct: 624 GERAEELENELH-----------HLEKE---NELLQKKITNLKITCEKIEALEQENSELE 669
Query: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSE------KLKKTEDKLQAAS---SQLQVEQNK 291
+ LK+ L K LT K S+ +L++ + L+ AS +QLQ+E +
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 292 VTTVTEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 348
+ + E+L +E K + K +E + E L+ L+ +K L S + L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 349 KNRLQSLEA-IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIED 407
+ Q+L+ +E+ + +K + K +L QE +++++ +++E+ +L+ I+D
Sbjct: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
Query: 408 DLMK--------TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAE-------K 452
++ E E +TL + ++ L KELE EL K + +
Sbjct: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVTLR 908
Query: 453 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEK-IHEYMATEDLICHLQGDHSVLQKKLN 511
+ E+ +++ + K H ++ KE+ +H+ +T+D + +L+ KL
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD------SRYKLLESKLE 962
Query: 512 QQENRNRDLGRE-IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPP 570
++ ++ E I L LE ++++ LR L + + + ++ + V + PP
Sbjct: 963 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022
Score = 89.0 bits (219), Expect = 2e-17
Identities = 129/604 (21%), Positives = 257/604 (42%), Gaps = 114/604 (18%)
Query: 5 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE------KELQTQ 58
E QRL L +KIQ+L + ++ + + ++E + + RLE K L+ +
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQE 823
Query: 59 TTKFHQDQ-----------------DTIM----AKLTNEDSQNRQLQQKLAALSR---QI 94
T++ +D+ DT + K+ N + +N+ L +++ ++
Sbjct: 824 TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL 883
Query: 95 DELEETNRSLRKAE----EELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI 150
ELE+ N+ L K + L ++E + + + ++E+L L+ G ++E +
Sbjct: 884 KELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE-LEKIGLNKERL 942
Query: 151 KMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE-KLEDAFNKS---KQECYSLKC 206
+EQ D ++ E+ K +E ++I ALE +LE++ N + +QE ++K
Sbjct: 943 LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002
Query: 207 NLE-------KERMT----------------TKQLSQELESLKVRIKELEAIESRLEKTE 243
N E +ERM +++ ++EL +K R+ E+E + L+ +
Sbjct: 1003 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062
Query: 244 FTLKEDLTKLKTLT-----VMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEK 298
LK L +L+T + +R+T+S L++ LQ +++LQVE + + + +
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVS--LQEQNTTLQTQNAKLQVENSTLNSQSTS 1120
Query: 299 LIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 358
L+ + + L ++ +E + SV KER+DLK+ + + ++ E +
Sbjct: 1121 LMNQNAQLLIQQSSLENENESVIKEREDLKS-----------------LYDSLIKDHEKL 1163
Query: 359 EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYET 418
E L++ +L ++ +K + +E ++ +D++ + L+K + + E
Sbjct: 1164 EL------LHERQASEYESLISKHGTLKSAHKNLE---VEHRDLEDRYNQLLKQKGQLED 1214
Query: 419 LERRYANERDKAQFLSKELEHVKMELAK---------------YKLAEKTETSHEQWLFK 463
LE+ E++K +K E V E K K E +T H+ L
Sbjct: 1215 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN-LKS 1273
Query: 464 RLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 523
L + + L E LKE +Y + L +L + E NR L +
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKE---QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ 1330
Query: 524 IENL 527
I+ L
Sbjct: 1331 IQTL 1334
Score = 65.5 bits (158), Expect = 2e-10
Identities = 86/347 (24%), Positives = 159/347 (45%), Gaps = 54/347 (15%)
Query: 14 TLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKE---LQTQTTKFHQDQDTIM 70
TLQ +K Q L T K+ T+ +A++ +++ L+++ LQTQ K + T+
Sbjct: 1057 TLQAEK-QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
Query: 71 AKLTNEDSQNRQLQQKLAALS-------RQIDELEETNRSLRKAEEELQDIKEK------ 117
++ T+ +QN QL + ++L ++ ++L+ SL K E+L+ + E+
Sbjct: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
Query: 118 --ISK-GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 174
ISK G +A EVE D+E + +L+K + Q DL K L K
Sbjct: 1176 SLISKHGTLKSAHKNLEVEH-----RDLEDRYNQLLKQKGQLEDLEKML----------K 1220
Query: 175 LEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM--TTKQLSQELESLKVRIKEL 232
+E EK+ LE+ +++ Y C E +R+ T QL +E E L+ K L
Sbjct: 1221 VEQEKM--------LLENKNHETVAAEYKKLCG-ENDRLNHTYSQLLKETEVLQTDHKNL 1271
Query: 233 EAI--ESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 290
+++ S+LE+T L+ + +KLK + S KL + L L+ E
Sbjct: 1272 KSLLNNSKLEQTR--LEAEFSKLKEQ----YQQLDITSTKLNNQCELLSQLKGNLEEENR 1325
Query: 291 KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 337
+ + L+ + + L+ + ++ + ++ D N+L+ ++EK
Sbjct: 1326 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1372
Score = 32.7 bits (73), Expect = 1.5
Identities = 28/132 (21%), Positives = 48/132 (36%), Gaps = 22/132 (16%)
Query: 4 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 63
D +QL + + +Q N K L + R++ E K ++L +TK +
Sbjct: 1248 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1307
Query: 64 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQ----------------------IDELEETN 101
+ + N + +NR L ++ L Q ID+L E
Sbjct: 1308 NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR 1367
Query: 102 RSLRKAEEELQD 113
R K EE++ D
Sbjct: 1368 RQKEKLEEKIMD 1379
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 102 bits (255), Expect = 1e-21
Identities = 151/651 (23%), Positives = 278/651 (42%), Gaps = 98/651 (15%)
Query: 20 IQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT-------KFHQDQDTIMA- 71
I+ + KE + +++E EQ+ +L+ E++ K H++QD ++
Sbjct: 1017 IEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKE 1076
Query: 72 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 131
K T +LQ+K L QI + E R+L + + + K KI + E E
Sbjct: 1077 KETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVE 1136
Query: 132 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 191
K D+ K+ ++K+E ++ + L+ +KD ++ KL + I L
Sbjct: 1137 CSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLT--- 1193
Query: 192 DAFNKSKQECYSLKCNLEKE---RMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKE 248
N + + L+ E+E R T++L +EL + R + L+A R E+ LKE
Sbjct: 1194 ---NNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKE 1250
Query: 249 DLTKLKT--------LTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL- 299
LT K ++VM DE K + K+ + E K S +L ++Q + + E+L
Sbjct: 1251 KLTDAKKQIKQVQKEVSVMR-DEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLN 1309
Query: 300 -------IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 352
I++ +RA K +V+EK+ +D++ L+ +E+ + + +L+ +L
Sbjct: 1310 NQKVEEAIQQYERACKD-LNVKEKII------EDMRMTLEEQEQTQ---VEQDQVLEAKL 1359
Query: 353 QSLE--AIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLM 410
+ +E A E + K K N K+ +Q +NK E + +V L + ++D+L
Sbjct: 1360 EEVERLATELEKWKEKCNDLETKN----NQRSNKEHENNTDV------LGKLTNLQDELQ 1409
Query: 411 KTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEA 470
++E +Y +++ E+ +KE E+++ + K K AE E FK+ E E
Sbjct: 1410 ESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMK-KYAEDRER-----FFKQQNEMEI 1463
Query: 471 KSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKE 530
+ L+ E D+ +K E + L+ L+ L Q++N L R I +K
Sbjct: 1464 LTAQLT-EKDSDLQKWRE--ERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSK- 1519
Query: 531 LERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 590
+ Q+ +++ + + + PD PL + +E
Sbjct: 1520 --------------------IETQIM--DIKPKRISSADPDKLQTEPLSTS------FEI 1551
Query: 591 SENQDEDPNDEGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTK 641
S N+ ED GSV+ C ST + + P ++ + LQ KM K
Sbjct: 1552 SRNKIED----GSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVK 1598
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/557 (21%), Positives = 244/557 (43%), Gaps = 52/557 (9%)
Query: 2 VVDEQQRLTAQ----LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQT 57
+V QQ L+ LTL ++ +Q++ +N +L + +++ QE+E+K +L E++T
Sbjct: 872 IVHFQQELSLSEKKNLTLSKE-VQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIET 930
Query: 58 QTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 117
T + I KL + + ++ +S ID L + S E+ L + +
Sbjct: 931 ATRSITNNVSQI--KLMHTKIDELRTLDSVSQISN-IDLLNLRDLSNGSEEDNLPNTQLD 987
Query: 118 ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK-MEEQCRDLNKRLERETLQSKDFKLE 176
+ +Y + +V+E R + + E I+ + E+C+++ K +++ Q ++ + +
Sbjct: 988 LLGNDYL---VSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQ 1044
Query: 177 VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT-KQLSQELESLKVR--IKELE 233
+EKL + + D N+ K++ + + +L KE+ T +QL +EL+ V ++
Sbjct: 1045 IEKLQAEVKGYK---DENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQH 1101
Query: 234 AIESRLEKTEFTLKEDL--TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNK 291
+E + +E T K+K L + ++ S K +D L+ S L++E+N
Sbjct: 1102 VVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERN- 1160
Query: 292 VTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNR 351
++ E + ++K+ D+ K + +E L N L+ + + LK
Sbjct: 1161 ----LKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQD--------MKHLLQLKEE 1208
Query: 352 LQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 411
+ E + LK +L+ S ++ K ++ + E+L K +K ++ ++
Sbjct: 1209 EEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSV 1268
Query: 412 TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAK 471
DE + L + K S+EL+ + + + K E + Q + + +Q+ E
Sbjct: 1269 MRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLK-----EQLNNQKVEEAIQQYERA 1323
Query: 472 SGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 531
L+ +KEKI ED+ L+ Q ++ Q + L E+E L EL
Sbjct: 1324 CKDLN-----VKEKI-----IEDMRMTLEEQE---QTQVEQDQVLEAKL-EEVERLATEL 1369
Query: 532 ERYRHFSKSLRPSLNGR 548
E+++ L N R
Sbjct: 1370 EKWKEKCNDLETKNNQR 1386
Score = 72.0 bits (175), Expect = 2e-12
Identities = 117/590 (19%), Positives = 241/590 (40%), Gaps = 80/590 (13%)
Query: 20 IQELTTNAKETHTKLALAEARVQEEEQKATRLE-----KELQTQTTKFHQDQDTIMAKLT 74
IQEL T+ K+ T+ + + +QK + K T K + DT +
Sbjct: 709 IQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIIN 768
Query: 75 NEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE---------LQDIKEKISKGEYGN 125
N+ N ++ + S+ E + N + + +E I E K E
Sbjct: 769 NKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVR 828
Query: 126 AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIM 185
I AE+E++R + EG L+ +E + ++ + Q F+ E+ K+ +
Sbjct: 829 PNI-AEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNL 887
Query: 186 ALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE----SLKVRIKELEAIES 237
L K ++ ++ + E + K +++ +LS E+E S+ + +++ + +
Sbjct: 888 TLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHT 947
Query: 238 RLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVE--------- 288
+++ E + ++++ + ++ + + SE+ +L + V
Sbjct: 948 KID--ELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQ 1005
Query: 289 ----QNKVTTVTEKLIEETKRALKSKTDVE----------EKMYSVTKERDDLKNKLKAE 334
+N + E + EE K +K+ + EK+ + K D N+LK +
Sbjct: 1006 EPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEK 1065
Query: 335 EEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQD-------SGKS-----TTALHQEN 382
E K D ++LK + ++ ++++ + + D GK T +
Sbjct: 1066 EHKNQD-----DLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYK 1120
Query: 383 NKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKM 442
KIKEL +E K++ +E D+++ E LER ++ Q K + + +
Sbjct: 1121 AKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNV 1180
Query: 443 ELAKYK--LAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMA-TEDLICHL 499
+ K K + + T + +L+EEE ++ +E + LKE++ A T++L L
Sbjct: 1181 KELKLKEEITQLTNNLQDMKHLLQLKEEEEETNR--QETEKLKEELSASSARTQNLKADL 1238
Query: 500 Q---GDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLN 546
Q D++ L++KL D ++I+ + KE+ R K LR +N
Sbjct: 1239 QRKEEDYADLKEKLT-------DAKKQIKQVQKEVSVMRDEDKLLRIKIN 1281
Score = 70.1 bits (170), Expect = 9e-12
Identities = 141/708 (19%), Positives = 292/708 (41%), Gaps = 132/708 (18%)
Query: 1 MVVDEQQRLTAQLTLQRQKIQELTTN--AKETHTKLALAEARVQEEEQKATRLE--KELQ 56
++ +++++LT + ++ + QE T +E K L + R EE RL K+L
Sbjct: 587 LINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLV 646
Query: 57 TQT-TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIK 115
+ T+ +D K+ E++ A L + ++++ L K + EL K
Sbjct: 647 GKCDTREEAAKDICATKVETEEAT--------ACLELKFNQIKA---ELAKTKGELIKTK 695
Query: 116 EKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDL---------------- 159
E++ K E + ++ E+E K+++ + +ELI + +Q D
Sbjct: 696 EELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFK 755
Query: 160 -------------NKRLERETLQ-SKDFKLEVEKLSKRI--MALEKLEDAFNKSKQECYS 203
NK + ET++ KD K ++ KR+ L++ E K S
Sbjct: 756 CNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSS 815
Query: 204 LKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL---KEDLTKLKTLTVMF 260
+K+ + E+E ++V + E + + L E L KE+ +L V F
Sbjct: 816 AITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHF 875
Query: 261 -----VDERK--TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIE---ETKRALKSK 310
+ E+K T+S+++++ + A ++L V+++K EK+++ E + A +S
Sbjct: 876 QQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSI 935
Query: 311 TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ------SLEAIEKDFLK 364
T+ ++ + + D+L+ + DLL+ ++ + L+ + D+L
Sbjct: 936 TNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLV 995
Query: 365 NK----------------------LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDM 402
+K + ++ + A +++++I+EL Q++E+L+ ++K
Sbjct: 996 SKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGY 1055
Query: 403 K-----------AIEDDLMKTEDEYETLERRYANE-RDKAQFLSKELEHVK--------- 441
K +DDL+K E ETL ++ E ++K L +++HV
Sbjct: 1056 KDENNRLKEKEHKNQDDLLK---EKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSEL 1112
Query: 442 -----------MELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYM 490
EL +K E SH L + + E+E+ L R + +E + + +
Sbjct: 1113 TQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSV 1172
Query: 491 A-TEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 549
T+D L L++++ Q N +D+ ++ +E E R ++ L+ L+
Sbjct: 1173 KNTKD----LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSA-- 1226
Query: 550 ISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDED 597
S + + + + + + D K + + I E S +DED
Sbjct: 1227 -SSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDED 1273
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.124 0.329
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,146,131
Number of Sequences: 37866
Number of extensions: 1585981
Number of successful extensions: 22437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 424
Number of HSP's successfully gapped in prelim test: 1386
Number of HSP's that attempted gapping in prelim test: 8018
Number of HSP's gapped (non-prelim): 6846
length of query: 893
length of database: 18,247,518
effective HSP length: 111
effective length of query: 782
effective length of database: 14,044,392
effective search space: 10982714544
effective search space used: 10982714544
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.