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Search of human proteins with 109659845
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109659845 filamin A interacting protein 1-like isoform 1
[Homo sapiens]
(1135 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 2216 0.0
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 2201 0.0
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom... 1729 0.0
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 934 0.0
gi|216548091 leucine zipper protein 1 [Homo sapiens] 259 1e-68
gi|216548085 leucine zipper protein 1 [Homo sapiens] 259 1e-68
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 146 1e-34
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 146 1e-34
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 146 1e-34
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 146 1e-34
gi|24308179 CTTNBP2 N-terminal like [Homo sapiens] 145 2e-34
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 134 6e-31
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 132 2e-30
gi|71061468 centromere protein E [Homo sapiens] 132 2e-30
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 127 5e-29
gi|45439327 periplakin [Homo sapiens] 124 4e-28
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 124 5e-28
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 122 2e-27
gi|58530840 desmoplakin isoform I [Homo sapiens] 120 6e-27
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 120 7e-27
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 119 2e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 119 2e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 119 2e-26
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 118 4e-26
gi|28416946 myosin 18A isoform a [Homo sapiens] 117 6e-26
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 116 1e-25
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 116 1e-25
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 116 1e-25
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 115 2e-25
gi|4506751 restin isoform a [Homo sapiens] 115 3e-25
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 2216 bits (5741), Expect = 0.0
Identities = 1135/1135 (100%), Positives = 1135/1135 (100%)
Query: 1 MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN 60
MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN
Sbjct: 1 MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN 60
Query: 61 GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ 120
GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ
Sbjct: 61 GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ 120
Query: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR
Sbjct: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
Query: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL
Sbjct: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
Query: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
Query: 301 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 301 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
Query: 361 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 361 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
Query: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
Query: 481 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 481 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 541 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 541 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
Query: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
Query: 661 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 661 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
Query: 721 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 721 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
Query: 781 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 781 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
Query: 841 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 841 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
Query: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
Query: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
Query: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
Query: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVEPLLLPH 1135
ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVEPLLLPH
Sbjct: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITVEPLLLPH 1135
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 2201 bits (5702), Expect = 0.0
Identities = 1128/1128 (100%), Positives = 1128/1128 (100%)
Query: 1 MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN 60
MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN
Sbjct: 1 MRSRGSDTEGSAQKKFPRHTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGN 60
Query: 61 GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ 120
GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ
Sbjct: 61 GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQ 120
Query: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR
Sbjct: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
Query: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL
Sbjct: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
Query: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
Query: 301 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 301 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
Query: 361 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 361 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
Query: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
Query: 481 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 481 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
Query: 541 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 541 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
Query: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
Query: 661 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 661 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
Query: 721 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 721 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
Query: 781 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 781 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
Query: 841 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 841 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
Query: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
Query: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
Query: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
Query: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV 1128
ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV
Sbjct: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV 1128
>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
sapiens]
Length = 893
Score = 1729 bits (4477), Expect = 0.0
Identities = 888/888 (100%), Positives = 888/888 (100%)
Query: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT
Sbjct: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
Query: 301 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 360
KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK
Sbjct: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
Query: 361 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL
Sbjct: 121 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 180
Query: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE
Sbjct: 181 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 240
Query: 481 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 540
KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI
Sbjct: 241 KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 300
Query: 541 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 600
EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK
Sbjct: 301 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK 360
Query: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE
Sbjct: 361 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 420
Query: 661 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD
Sbjct: 421 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 480
Query: 721 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 780
ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS
Sbjct: 481 ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKS 540
Query: 781 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 840
LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND
Sbjct: 541 LRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPND 600
Query: 841 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ
Sbjct: 601 EGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 660
Query: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK
Sbjct: 661 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 720
Query: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP
Sbjct: 721 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 780
Query: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 1080
EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP
Sbjct: 781 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASPVRP 840
Query: 1081 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV 1128
ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV
Sbjct: 841 ASPSAPLQDNRTQGLINGALNKTTNKVTSSITITPTATPLPRQSQITV 888
Score = 103 bits (258), Expect = 7e-22
Identities = 103/427 (24%), Positives = 197/427 (46%), Gaps = 24/427 (5%)
Query: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLA-----LLEAQYGFVTPKKVLEAL 119
ED L L+ L ++ +E L+ + +L + + +YG +E L
Sbjct: 76 EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 135
Query: 120 QRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILE-LEEE 178
++ + + E+ +L+K +E+ E+ + +L V + S+R LE LE+
Sbjct: 136 RKRVLDMEGKDEELIKMEEQCRDLNKRLER--ETLQSKDFKLEVEKLSKRIMALEKLEDA 193
Query: 179 KRKHKEY-------MEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEE 231
K K+ +EK L QE E LK IK E E EK TLKE+
Sbjct: 194 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKV----RIKELEAIESRLEKTEFTLKED 249
Query: 232 LTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRL 291
LTKLK+ +M VDE++ ++ +L K+Q ++ + K+ ++ EE ++A +
Sbjct: 250 LTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKS 309
Query: 292 EKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
+ +++ + +++D + KL E+ + L ++ L ++ LE + K +
Sbjct: 310 KTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQ 369
Query: 352 QDIKEKISKGEYGN--AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ 409
K + + N + EVE L+ ++ DM+ +++L+K E++ L +R E +
Sbjct: 370 DSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDK 429
Query: 410 SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI 469
++ E+E + K +A KL + S ++ L L++E + LS+E+++LK +I
Sbjct: 430 AQFLSKELEHV-KMELAKYKLAEKTETSHEQW--LFKRLQEEEAKSGHLSREVDALKEKI 486
Query: 470 KELEAIE 476
E A E
Sbjct: 487 HEYMATE 493
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 934 bits (2413), Expect = 0.0
Identities = 518/1078 (48%), Positives = 727/1078 (67%), Gaps = 26/1078 (2%)
Query: 66 DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQ 125
+LS++DL+ LLSI+EGELQAR++VI +LK EK +LEA YG P+KVL L RDA
Sbjct: 74 ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAIL 133
Query: 126 AKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEY 185
A+ ED+YEKP++ELD++ EK KE+YRR+L QLL+AEK R+T+ ELE EK KH +Y
Sbjct: 134 AQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDY 193
Query: 186 MEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDE 245
M KSD+F LLEQE ERLKKL++QE Q KE+E KR+ L++EL KLKSFALM+VDE
Sbjct: 194 MNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDE 253
Query: 246 QQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQD 305
+Q QL LQ QK+Q+LT +E KL ++ +E+ QK +LE + + + ++F Q+
Sbjct: 254 RQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQE 313
Query: 306 QDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN 365
+ + AKL N++S NRQL+ KL L+++I+ELEETN++L+KAEEELQ++++KI+KGE GN
Sbjct: 314 HEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGN 373
Query: 366 AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIM 425
+ +MAEVE LRKRVL+MEGKDEE+ K E QCR+L K+L+ E SK+ +LEVEKL KR+
Sbjct: 374 SSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMS 433
Query: 426 ALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 485
LEKLE+AF+KSK EC L NLEKE+ TK L ELE +K R+KELE ESRLEK E +
Sbjct: 434 ELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELS 493
Query: 486 LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKR 545
LK+DLTKLK+ TVM VDERK M EK+K+ E K+ + +VEQ KV VTEKLIEE+K+
Sbjct: 494 LKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKK 553
Query: 546 ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 605
LK K+++EEK+Y++T+ERD+L KLK+EEEK ++L V++LK RL +E +E++ +
Sbjct: 554 LLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRG 613
Query: 606 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
+ S K + E+NKIKEL+ E+ERLK +L+ ++ +E DLMKTEDEY+ LE+++
Sbjct: 614 R----SRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRT 669
Query: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTE-TSHEQWLFKRLQEEEAKSGHLSREVDALKE 724
E+DKA FLS++LE +K ++AK K EK E S E L R + EEAKS L EV ALKE
Sbjct: 670 EQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKE 729
Query: 725 KIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 784
KIHE M ED + LQ D+SVLQ++ ++EN+N+++G+E+ NLTKELE + +S++LRPS
Sbjct: 730 KIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPS 789
Query: 785 LNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQD---EDPNDE 841
+NGRR+ D V S VQT+AV E + ++ R + + S + + P +
Sbjct: 790 VNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVER 849
Query: 842 GSVLSFKCSQSTPCPVNRKLWIPWMKSKE-GHLQNGKMQTKPNANFVQPGDLVLSHTPGQ 900
SVL + + RK WIPWM+ +E G + + N++ PG++VLS GQ
Sbjct: 850 SSVLDRYPPAANELTM-RKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQ 908
Query: 901 PLHIKVTPDHVQNTATLEITSPTTESPHSYTSTAVIPNCGTPKQRITILQNASITPVKSK 960
PLHI+VTPDH +TATLEITSPT+E ++ST VIP G K RITI+ + ++ P K K
Sbjct: 909 PLHIRVTPDHENSTATLEITSPTSE--EFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQK 966
Query: 961 TSTEDLMNLEQGMSPITMATFARAQTPESCGSLTPERTMSPIQVLAVTGSASSPEQGRSP 1020
S + + E+ MSP+T+ TF+R +TPES +R SPIQ++ V+ SA+ E SP
Sbjct: 967 -SGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSP 1025
Query: 1021 EPTEISAKHAIFRVSPDRQSSWQFQRSNSNSSSVITTEDNKIHIHLGSPYMQAVASP--- 1077
E E+ I +V+P++Q+ R ++++++ITTEDNKIHIHLGS + ++ +
Sbjct: 1026 ESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTSGEG 1085
Query: 1078 VRPASPSAPLQDNRTQGLINGALNKT----------TNKVTSSITITPTATPLPRQSQ 1125
V P P+ + + G + ++ +KVTS+ITITP T R +Q
Sbjct: 1086 VSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSARGTQ 1143
>gi|216548091 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 259 bits (662), Expect = 1e-68
Identities = 152/423 (35%), Positives = 262/423 (61%), Gaps = 43/423 (10%)
Query: 310 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367
MA+ T+ E + +R L+ KL +LSR++DELEE ++L+KAE+EL D+++K+ + E N+
Sbjct: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
Query: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E +++ K E+E+L KR+ L
Sbjct: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487
EKLE+AF++SK +C L +L +ER TK++S ELE L+V++KELE+ E RL+KTE +L
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
Query: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547
+L KLK+LT+ FV ERK ++EK K+ E ++ + +L EQNK + +
Sbjct: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------KMNRDYT 229
Query: 548 KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 607
++ +++E +N L+ E+ + L S+ + K L L+ +E + +NK
Sbjct: 230 RNASNLE-------------RNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKS 275
Query: 608 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER 667
+ + +QE+NK+K+L+QE+E+LK ++K +++E++L K + + L+ Y +E+
Sbjct: 276 ENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQ 330
Query: 668 DKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHLS 716
+K + L+ +LE +K+++ K K E E HE+ F+ E + S H +
Sbjct: 331 NKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTA 390
Query: 717 REV 719
RE+
Sbjct: 391 REL 393
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)
Query: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
KE +++ L +L+SL R+ ELE L+K E DE + +
Sbjct: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
Query: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
K+ + E + ++++V + +V + K EE KRA E + + KE
Sbjct: 50 KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
Query: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
KL+ EE +L S + L+ R+ LE +E+ F ++K D + +L++E N K++S
Sbjct: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
Query: 630 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 676
E+E L++K+K++++ ED L KTE E E L ER+Y NE++K K
Sbjct: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
Query: 677 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
++ + +L + K + T + L + L+ E+ S L + K + E+
Sbjct: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 795
+ S +K NQ++N+ +DL +EIE L +++ + + L+ +
Sbjct: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
Query: 796 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 830
S++ + + + ++ + K I ++ + NG++ E
Sbjct: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
Score = 77.8 bits (190), Expect = 5e-14
Identities = 96/431 (22%), Positives = 183/431 (42%), Gaps = 51/431 (11%)
Query: 191 EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
EF E R + Q + + ++ +E K + ++EL L+ + +
Sbjct: 3 EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62
Query: 251 AQLTLQRQKIQELTTNAKETHTKLA-----LAEARVQEEEQKATRLEKE----------- 294
A++ + RQ++ L K+ K A L + +++EEE L+ E
Sbjct: 63 AEIEVLRQRV--LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
Query: 295 --LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
L+ ++ D + L E + +++ +L L ++ ELE + L K E+ L
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
Query: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------ 406
EK+ + RK + + E ++E+LIK Q + NK++ R+
Sbjct: 181 SELEKLK-------SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
Query: 407 TLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
L+ D ++E K S+R L+ L+ N+++ + + K N +E K L+
Sbjct: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLN 292
Query: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDK 517
QE+E LK +IK E++E L+K +K L+ + ++ K ++ +L+ K + K
Sbjct: 293 QEIEKLKTQIKHFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348
Query: 518 LQAASSQLQVEQNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKA 573
Q +VE ++ E TK R S+ V + + S +R+ L+N+ A
Sbjct: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
Query: 574 EEEKGNDLLSR 584
+ L +R
Sbjct: 409 LNNENYSLSNR 419
Score = 70.5 bits (171), Expect = 9e-12
Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)
Query: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
T K A+S L+ + ++ ++L E TK K++ ++ DL++K+
Sbjct: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
Query: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 632
E + +L+ + +L+ R+ +E +++ K +D + L +E N +EL E+
Sbjct: 54 AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
Query: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
ERL+ ++ +++ +E+ +++++ L ER+ + +S ELE +++++ + + +E
Sbjct: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
Query: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752
EQ L L++ ++ + E L EK E E LI L +KL Q
Sbjct: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
Query: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 789
+ NRD R NL + R S PS RR
Sbjct: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
Score = 70.5 bits (171), Expect = 9e-12
Identities = 83/414 (20%), Positives = 165/414 (39%), Gaps = 59/414 (14%)
Query: 149 KHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF----------ICLLEQ 198
K E R++ + L E++ + + E +K +EK +E +CL
Sbjct: 83 KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
Query: 199 ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA 251
E L K I E +K E E +K +L EL KLKS L V E++ L
Sbjct: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
Query: 252 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311
+ + I+ELT ++ ++ + TR L+ + +D I +
Sbjct: 203 KEKENEKLIKELTQKLEQN-----------KKMNRDYTRNASNLERNDLRI---EDGISS 248
Query: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
L +++S+ + L + + E ++ + + +++D+ + E
Sbjct: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQ--------------E 294
Query: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
+E+L+ ++ E +EEL KM+ + DL E ++K ++E++ +I ++LE
Sbjct: 295 IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354
Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED-- 489
+ + + S K E+ + + R + RL EF L +
Sbjct: 355 NGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY 414
Query: 490 -LTKLKTLTVMFVDERKTM-----------SEKLKKTEDKLQAASSQLQVEQNK 531
L+ + + F + R +++ KKTED+ SSQ + ++++
Sbjct: 415 SLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
>gi|216548085 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 259 bits (662), Expect = 1e-68
Identities = 152/423 (35%), Positives = 262/423 (61%), Gaps = 43/423 (10%)
Query: 310 MAKLTN--EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367
MA+ T+ E + +R L+ KL +LSR++DELEE ++L+KAE+EL D+++K+ + E N+
Sbjct: 1 MAEFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSS 60
Query: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
++AE+E LR+RVL +EGKDEE+ + E+ CR + ++LE E +++ K E+E+L KR+ L
Sbjct: 61 MLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK 487
EKLE+AF++SK +C L +L +ER TK++S ELE L+V++KELE+ E RL+KTE +L
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
Query: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRAL 547
+L KLK+LT+ FV ERK ++EK K+ E ++ + +L EQNK + +
Sbjct: 181 SELEKLKSLTLSFVSERKYLNEKEKENEKLIKELTQKL--EQNK---------KMNRDYT 229
Query: 548 KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 607
++ +++E +N L+ E+ + L S+ + K L L+ +E + +NK
Sbjct: 230 RNASNLE-------------RNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE-TRNKS 275
Query: 608 NQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER 667
+ + +QE+NK+K+L+QE+E+LK ++K +++E++L K + + L+ Y +E+
Sbjct: 276 ENEKNR-----NQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQ 330
Query: 668 DKAQFLSKELEHVKMELAKYKLAEKTETS-----------HEQWLFKRLQEEEAKSGHLS 716
+K + L+ +LE +K+++ K K E E HE+ F+ E + S H +
Sbjct: 331 NKNKLLASQLEEIKLQIKKQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTA 390
Query: 717 REV 719
RE+
Sbjct: 391 REL 393
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/395 (24%), Positives = 183/395 (46%), Gaps = 55/395 (13%)
Query: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
KE +++ L +L+SL R+ ELE L+K E DE + +
Sbjct: 8 KETASSRHLRFKLQSLSRRLDELEEATKNLQKAE------------------DELLDLQD 49
Query: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
K+ + E + ++++V + +V + K EE KRA E + + KE
Sbjct: 50 KVIQAEGSNSSMLAEIEVLRQRVLRIEGK-DEEIKRA--------EDLCRLMKE------ 94
Query: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
KL+ EE +L S + L+ R+ LE +E+ F ++K D + +L++E N K++S
Sbjct: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSK--NDCTQLCLSLNEERNLTKKIS 152
Query: 630 QEVERLKLKLKDMKAIEDDLMKTED----EYETL---------ERRYANERDKAQFLSKE 676
E+E L++K+K++++ ED L KTE E E L ER+Y NE++K K
Sbjct: 153 SELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKEN--EKL 210
Query: 677 LEHVKMELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
++ + +L + K + T + L + L+ E+ S L + K + E+
Sbjct: 211 IKELTQKLEQNKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENE 270
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQV 795
+ S +K NQ++N+ +DL +EIE L +++ + + L+ +
Sbjct: 271 T----RNKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMKSKNNDLQDNY 326
Query: 796 FSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEE 830
S++ + + + ++ + K I ++ + NG++ E
Sbjct: 327 LSEQNKNKLLASQLEEIKLQIKKQKELENGEVEGE 361
Score = 77.8 bits (190), Expect = 5e-14
Identities = 96/431 (22%), Positives = 183/431 (42%), Gaps = 51/431 (11%)
Query: 191 EFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
EF E R + Q + + ++ +E K + ++EL L+ + +
Sbjct: 3 EFTSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSML 62
Query: 251 AQLTLQRQKIQELTTNAKETHTKLA-----LAEARVQEEEQKATRLEKE----------- 294
A++ + RQ++ L K+ K A L + +++EEE L+ E
Sbjct: 63 AEIEVLRQRV--LRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAEL 120
Query: 295 --LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
L+ ++ D + L E + +++ +L L ++ ELE + L K E+ L
Sbjct: 121 EKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLA 180
Query: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE------ 406
EK+ + RK + + E ++E+LIK Q + NK++ R+
Sbjct: 181 SELEKLK-------SLTLSFVSERKYLNEKEKENEKLIKELTQKLEQNKKMNRDYTRNAS 233
Query: 407 TLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
L+ D ++E K S+R L+ L+ N+++ + + K N +E K L+
Sbjct: 234 NLERNDLRIEDGISSTLPSKESRRKGGLDYLKQVENETRNKSENEK-NRNQEDNKVKDLN 292
Query: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK--KTEDK 517
QE+E LK +IK E++E L+K +K L+ + ++ K ++ +L+ K + K
Sbjct: 293 QEIEKLKTQIKHFESLEEELKK----MKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIK 348
Query: 518 LQAASSQLQVEQNKVTTVTEKLIEETK-RALKSKTDVEE---KMYSVTKERDDLKNKLKA 573
Q +VE ++ E TK R S+ V + + S +R+ L+N+ A
Sbjct: 349 KQKELENGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFA 408
Query: 574 EEEKGNDLLSR 584
+ L +R
Sbjct: 409 LNNENYSLSNR 419
Score = 70.5 bits (171), Expect = 9e-12
Identities = 66/277 (23%), Positives = 128/277 (46%), Gaps = 25/277 (9%)
Query: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
T K A+S L+ + ++ ++L E TK K++ ++ DL++K+
Sbjct: 5 TSYKETASSRHLRFKLQSLSRRLDELEEATKNLQKAEDELL-----------DLQDKVIQ 53
Query: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK-STTALHQENNKIKELSQEV 632
E + +L+ + +L+ R+ +E +++ K +D + L +E N +EL E+
Sbjct: 54 AEGSNSSMLAEIEVLRQRVLRIEGKDEEI---KRAEDLCRLMKEKLEEEENLTRELKSEI 110
Query: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
ERL+ ++ +++ +E+ +++++ L ER+ + +S ELE +++++ + + +E
Sbjct: 111 ERLQKRMAELEKLEEAFSRSKNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSED 170
Query: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752
EQ L L++ ++ + E L EK E E LI L +KL Q
Sbjct: 171 RLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE---NEKLI-------KELTQKLEQ 220
Query: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRR 789
+ NRD R NL + R S PS RR
Sbjct: 221 NKKMNRDYTRNASNLERNDLRIEDGISSTLPSKESRR 257
Score = 70.5 bits (171), Expect = 9e-12
Identities = 83/414 (20%), Positives = 165/414 (39%), Gaps = 59/414 (14%)
Query: 149 KHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF----------ICLLEQ 198
K E R++ + L E++ + + E +K +EK +E +CL
Sbjct: 83 KRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRSKNDCTQLCLSLN 142
Query: 199 ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA 251
E L K I E +K E E +K +L EL KLKS L V E++ L
Sbjct: 143 EERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNE 202
Query: 252 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311
+ + I+ELT ++ ++ + TR L+ + +D I +
Sbjct: 203 KEKENEKLIKELTQKLEQN-----------KKMNRDYTRNASNLERNDLRI---EDGISS 248
Query: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
L +++S+ + L + + E ++ + + +++D+ + E
Sbjct: 249 TLPSKESRRKGGLDYLKQVENETRNKSENEKNRNQEDNKVKDLNQ--------------E 294
Query: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
+E+L+ ++ E +EEL KM+ + DL E ++K ++E++ +I ++LE
Sbjct: 295 IEKLKTQIKHFESLEEELKKMKSKNNDLQDNYLSEQNKNKLLASQLEEIKLQIKKQKELE 354
Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED-- 489
+ + + S K E+ + + R + RL EF L +
Sbjct: 355 NGEVEGEDAFLSSKGRHERTKFRGHGSEASVSKHTARELSPQHKRERLRNREFALNNENY 414
Query: 490 -LTKLKTLTVMFVDERKTM-----------SEKLKKTEDKLQAASSQLQVEQNK 531
L+ + + F + R +++ KKTED+ SSQ + ++++
Sbjct: 415 SLSNRQVSSPSFTNRRAAKASHMGVSTDSGTQETKKTEDRFVPGSSQSEGKKSR 468
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 146 bits (368), Expect = 1e-34
Identities = 192/788 (24%), Positives = 345/788 (43%), Gaps = 137/788 (17%)
Query: 109 FVTPKKVLEAL-QRDAFQAKSTPWQE--DIYEKPMNELDKVVEKHKESYRRILGQLLVAE 165
F K +L+ Q + QAK Q+ + +K NEL ++ +KH + + L+ E
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQE 894
Query: 166 KSRRQTILELEEEKR------KHKEYMEKSDEFICLLEQECER-------LKKLIDQEIK 212
+ + +T L E E+ K +E E E LE+E +R KK+ Q +
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 213 SQEEKEQEKEKRVTTLKEELT------KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
+E+ E+E+ R E++T KL+ L++ D+ +L+ + L ++I +LTTN
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 267 AKETHTK--------------LALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTI 309
E K ++ E R+++EE+ LEK +L+ + FH+ +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 310 MAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLRKAEE---ELQDIKEKI------- 358
A++ Q + +++L AAL+R DE+ + N +L+K E + D++E +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 359 SKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFK 414
+K E + E+E L+ + LD +EL K E++ L K L+ ET +S + +
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-RSHEAQ 1193
Query: 415 LE---------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-- 463
++ VE+L++++ ++ + +K+KQ +L E Q QE+E
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 464 --SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
L+ +++EL++ S E+ L + + KL+ K K + +
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
SSQLQ Q E L EET++ K +V K+ + +ER+ L+++L E E +L
Sbjct: 1314 SSQLQDTQ-------ELLQEETRQ----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 582 LSRVNML-------KNRLQ----SLEAIE---KDFLK--NKLNQDSGKSTTALHQENNKI 625
++ L K +LQ ++EA+E K F K L Q + A +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 626 KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL-------ERRYANERDKAQFLSKELE 678
L QE++ L + L + + + +L K + +++ L +YA+ERD+A+ ++E E
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 679 HVKMELAKYKLAEKTETSHE-------------------QWLFKRLQEEEAKSGHLSREV 719
+ LA+ L E E E + K + E E L ++
Sbjct: 1483 TKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 720 DALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENL 767
+ +K ++ E ATED L+ + LQ + Q E + R L R++
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 768 TKELERYR 775
ELE R
Sbjct: 1602 ETELEDER 1609
Score = 127 bits (319), Expect = 6e-29
Identities = 157/696 (22%), Positives = 302/696 (43%), Gaps = 86/696 (12%)
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
EK EL+K+ K + Q+ + + ++L +++ + + + + D+ I
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 197 EQECERLKKL------IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
+++++L + +++ S+ + EK+ L EEL LK+ + D
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTA 1163
Query: 251 AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
Q L+ ++ QE+T K + EA+VQE QK + +EL Q +F + + +
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 311 AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
+ +N L +L L + E+E +K E ++Q+++ K S GE A +
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGERARAELND 1280
Query: 371 EVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ-----SKDFK 414
+V +L+ V + EGK +L K + Q +D + L+ ET Q +K +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 415 LEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMTTKQLSQE 461
LE E+ S + E++E N SK++ +E K+ +E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
+E+L + +E A +LEKT+ L+++L L V+ +D ++ + L+K + K
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKKQRKF--- 1453
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
QL E+ +++ K +E RA + E K S+ + L+ L+A+EE
Sbjct: 1454 -DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAKEE----- 1501
Query: 582 LSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQEVE----- 633
L R N MLK ++ L + + D KN +L + T + + +++EL E++
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 634 --RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQFLSKELEH 679
RL++ ++ +K E DL +++ E R+ +ER + + +
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Query: 680 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT----EDL 735
++ +L +L + + K+L++ +A+ RE++ + E AT E
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
L+ D LQ+ L E + E E L +EL
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Score = 121 bits (303), Expect = 4e-27
Identities = 151/660 (22%), Positives = 288/660 (43%), Gaps = 61/660 (9%)
Query: 132 QEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
QE + E+ +L+ + +E+ + S + L + + A+++ + I L + K+ +
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 187 EKSDEFICLLEQECERLKKLIDQEIKSQEEKE---QEKEKRVTTLKEELTKLKSFALMVV 243
+ + LE+ +R +K I+ + EEK + EK L++EL L ++ +
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDL 1436
Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQT 299
D Q++L + L +++K +L K +K A AEA +E+E KA L + L+
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496
Query: 300 -TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQDI 354
K ++ M K ED L + + + ELE++ R+L EE L+++
Sbjct: 1497 EAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 355 KEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 413
++++ E + ++ L+ + D++ +DE+ EE+ R L ++L + +D
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELEDE 1608
Query: 414 KLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
+ + +KL + LE D+ K ++E L K + K +ELE +
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDAR 1665
Query: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS--- 523
E+ A EK +L+ DL +L+ + ER L+K E + ASS
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 524 --QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE------ 575
LQ E+ ++ +L EE + + + +++ T++ + L N+L E
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 576 EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
E L R N L+++L +E K K+ + K Q + +E +
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE 694
LK K K +K I L++ EDE + E+ Y + +K K+L K +L + + +
Sbjct: 1844 LKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQRI 1896
Query: 695 TSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQE 754
++ + L + L E + + REV+ALK K+ T + G V++ +E
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1956
Score = 62.8 bits (151), Expect = 2e-09
Identities = 75/370 (20%), Positives = 155/370 (41%), Gaps = 43/370 (11%)
Query: 80 EGELQARDEVIGILKAE-KMDLALLEAQYGFVTPKKVLEALQRDAFQA--KSTPWQEDIY 136
E +LQARDE + + + L E + ++ L A + + K Q D
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK----EYMEKSDEF 192
K E K + K + + +L A SR + +E ++K K + M+ ++
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 193 ICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
ER +K D E + E+ L++E +L++ + +E +
Sbjct: 1697 AA-----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 253 LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
+ ++++ T A++ +LA + Q+ E +LE++ + +K H+ + + +K
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 313 LTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDI-------------- 354
S L+ K+A L Q++ E + +SL++ +++L++I
Sbjct: 1812 F---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 355 KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
KE+ KG A V++L+++ +E +EE ++ R L + L+ T ++
Sbjct: 1869 KEQAEKGN-------ARVKQLKRQ---LEEAEEESQRINANRRKLQRELDEATESNEAMG 1918
Query: 415 LEVEKLSKRI 424
EV L ++
Sbjct: 1919 REVNALKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 146 bits (368), Expect = 1e-34
Identities = 192/788 (24%), Positives = 345/788 (43%), Gaps = 137/788 (17%)
Query: 109 FVTPKKVLEAL-QRDAFQAKSTPWQE--DIYEKPMNELDKVVEKHKESYRRILGQLLVAE 165
F K +L+ Q + QAK Q+ + +K NEL ++ +KH + + L+ E
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQE 901
Query: 166 KSRRQTILELEEEKR------KHKEYMEKSDEFICLLEQECER-------LKKLIDQEIK 212
+ + +T L E E+ K +E E E LE+E +R KK+ Q +
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 213 SQEEKEQEKEKRVTTLKEELT------KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
+E+ E+E+ R E++T KL+ L++ D+ +L+ + L ++I +LTTN
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 267 AKETHTK--------------LALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTI 309
E K ++ E R+++EE+ LEK +L+ + FH+ +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 310 MAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLRKAEE---ELQDIKEKI------- 358
A++ Q + +++L AAL+R DE+ + N +L+K E + D++E +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 359 SKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFK 414
+K E + E+E L+ + LD +EL K E++ L K L+ ET +S + +
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-RSHEAQ 1200
Query: 415 LE---------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-- 463
++ VE+L++++ ++ + +K+KQ +L E Q QE+E
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 464 --SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
L+ +++EL++ S E+ L + + KL+ K K + +
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
SSQLQ Q E L EET++ K +V K+ + +ER+ L+++L E E +L
Sbjct: 1321 SSQLQDTQ-------ELLQEETRQ----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 582 LSRVNML-------KNRLQ----SLEAIE---KDFLK--NKLNQDSGKSTTALHQENNKI 625
++ L K +LQ ++EA+E K F K L Q + A +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 626 KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL-------ERRYANERDKAQFLSKELE 678
L QE++ L + L + + + +L K + +++ L +YA+ERD+A+ ++E E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 679 HVKMELAKYKLAEKTETSHE-------------------QWLFKRLQEEEAKSGHLSREV 719
+ LA+ L E E E + K + E E L ++
Sbjct: 1490 TKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 720 DALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENL 767
+ +K ++ E ATED L+ + LQ + Q E + R L R++
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 768 TKELERYR 775
ELE R
Sbjct: 1609 ETELEDER 1616
Score = 127 bits (319), Expect = 6e-29
Identities = 157/696 (22%), Positives = 302/696 (43%), Gaps = 86/696 (12%)
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
EK EL+K+ K + Q+ + + ++L +++ + + + + D+ I
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 197 EQECERLKKL------IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
+++++L + +++ S+ + EK+ L EEL LK+ + D
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTA 1170
Query: 251 AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
Q L+ ++ QE+T K + EA+VQE QK + +EL Q +F + + +
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 311 AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
+ +N L +L L + E+E +K E ++Q+++ K S GE A +
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGERARAELND 1287
Query: 371 EVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ-----SKDFK 414
+V +L+ V + EGK +L K + Q +D + L+ ET Q +K +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 415 LEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMTTKQLSQE 461
LE E+ S + E++E N SK++ +E K+ +E
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
+E+L + +E A +LEKT+ L+++L L V+ +D ++ + L+K + K
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKKQRKF--- 1460
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
QL E+ +++ K +E RA + E K S+ + L+ L+A+EE
Sbjct: 1461 -DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAKEE----- 1508
Query: 582 LSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQEVE----- 633
L R N MLK ++ L + + D KN +L + T + + +++EL E++
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 634 --RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQFLSKELEH 679
RL++ ++ +K E DL +++ E R+ +ER + + +
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Query: 680 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT----EDL 735
++ +L +L + + K+L++ +A+ RE++ + E AT E
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
L+ D LQ+ L E + E E L +EL
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Score = 121 bits (303), Expect = 4e-27
Identities = 151/660 (22%), Positives = 288/660 (43%), Gaps = 61/660 (9%)
Query: 132 QEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
QE + E+ +L+ + +E+ + S + L + + A+++ + I L + K+ +
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 187 EKSDEFICLLEQECERLKKLIDQEIKSQEEKE---QEKEKRVTTLKEELTKLKSFALMVV 243
+ + LE+ +R +K I+ + EEK + EK L++EL L ++ +
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDL 1443
Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQT 299
D Q++L + L +++K +L K +K A AEA +E+E KA L + L+
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503
Query: 300 -TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQDI 354
K ++ M K ED L + + + ELE++ R+L EE L+++
Sbjct: 1504 EAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 355 KEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 413
++++ E + ++ L+ + D++ +DE+ EE+ R L ++L + +D
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELEDE 1615
Query: 414 KLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
+ + +KL + LE D+ K ++E L K + K +ELE +
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDAR 1672
Query: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS--- 523
E+ A EK +L+ DL +L+ + ER L+K E + ASS
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 524 --QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE------ 575
LQ E+ ++ +L EE + + + +++ T++ + L N+L E
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 576 EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
E L R N L+++L +E K K+ + K Q + +E +
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE 694
LK K K +K I L++ EDE + E+ Y + +K K+L K +L + + +
Sbjct: 1851 LKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQRI 1903
Query: 695 TSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQE 754
++ + L + L E + + REV+ALK K+ T + G V++ +E
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEE 1963
Score = 62.8 bits (151), Expect = 2e-09
Identities = 75/370 (20%), Positives = 155/370 (41%), Gaps = 43/370 (11%)
Query: 80 EGELQARDEVIGILKAE-KMDLALLEAQYGFVTPKKVLEALQRDAFQA--KSTPWQEDIY 136
E +LQARDE + + + L E + ++ L A + + K Q D
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK----EYMEKSDEF 192
K E K + K + + +L A SR + +E ++K K + M+ ++
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 193 ICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
ER +K D E + E+ L++E +L++ + +E +
Sbjct: 1704 AA-----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 253 LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
+ ++++ T A++ +LA + Q+ E +LE++ + +K H+ + + +K
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 313 LTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDI-------------- 354
S L+ K+A L Q++ E + +SL++ +++L++I
Sbjct: 1819 F---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 355 KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
KE+ KG A V++L+++ +E +EE ++ R L + L+ T ++
Sbjct: 1876 KEQAEKGN-------ARVKQLKRQ---LEEAEEESQRINANRRKLQRELDEATESNEAMG 1925
Query: 415 LEVEKLSKRI 424
EV L ++
Sbjct: 1926 REVNALKSKL 1935
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 146 bits (368), Expect = 1e-34
Identities = 192/788 (24%), Positives = 345/788 (43%), Gaps = 137/788 (17%)
Query: 109 FVTPKKVLEAL-QRDAFQAKSTPWQE--DIYEKPMNELDKVVEKHKESYRRILGQLLVAE 165
F K +L+ Q + QAK Q+ + +K NEL ++ +KH + + L+ E
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQE 901
Query: 166 KSRRQTILELEEEKR------KHKEYMEKSDEFICLLEQECER-------LKKLIDQEIK 212
+ + +T L E E+ K +E E E LE+E +R KK+ Q +
Sbjct: 902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 213 SQEEKEQEKEKRVTTLKEELT------KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
+E+ E+E+ R E++T KL+ L++ D+ +L+ + L ++I +LTTN
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021
Query: 267 AKETHTK--------------LALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTI 309
E K ++ E R+++EE+ LEK +L+ + FH+ +
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1081
Query: 310 MAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLRKAEE---ELQDIKEKI------- 358
A++ Q + +++L AAL+R DE+ + N +L+K E + D++E +
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 359 SKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFK 414
+K E + E+E L+ + LD +EL K E++ L K L+ ET +S + +
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-RSHEAQ 1200
Query: 415 LE---------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-- 463
++ VE+L++++ ++ + +K+KQ +L E Q QE+E
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 464 --SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
L+ +++EL++ S E+ L + + KL+ K K + +
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
SSQLQ Q E L EET++ K +V K+ + +ER+ L+++L E E +L
Sbjct: 1321 SSQLQDTQ-------ELLQEETRQ----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 582 LSRVNML-------KNRLQ----SLEAIE---KDFLK--NKLNQDSGKSTTALHQENNKI 625
++ L K +LQ ++EA+E K F K L Q + A +
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 626 KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL-------ERRYANERDKAQFLSKELE 678
L QE++ L + L + + + +L K + +++ L +YA+ERD+A+ ++E E
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 679 HVKMELAKYKLAEKTETSHE-------------------QWLFKRLQEEEAKSGHLSREV 719
+ LA+ L E E E + K + E E L ++
Sbjct: 1490 TKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 720 DALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENL 767
+ +K ++ E ATED L+ + LQ + Q E + R L R++
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 768 TKELERYR 775
ELE R
Sbjct: 1609 ETELEDER 1616
Score = 127 bits (319), Expect = 6e-29
Identities = 157/696 (22%), Positives = 302/696 (43%), Gaps = 86/696 (12%)
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
EK EL+K+ K + Q+ + + ++L +++ + + + + D+ I
Sbjct: 1054 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1113
Query: 197 EQECERLKKL------IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
+++++L + +++ S+ + EK+ L EEL LK+ + D
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTA 1170
Query: 251 AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
Q L+ ++ QE+T K + EA+VQE QK + +EL Q +F + + +
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 311 AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
+ +N L +L L + E+E +K E ++Q+++ K S GE A +
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGERARAELND 1287
Query: 371 EVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ-----SKDFK 414
+V +L+ V + EGK +L K + Q +D + L+ ET Q +K +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 415 LEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMTTKQLSQE 461
LE E+ S + E++E N SK++ +E K+ +E
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
+E+L + +E A +LEKT+ L+++L L V+ +D ++ + L+K + K
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKKQRKF--- 1460
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
QL E+ +++ K +E RA + E K S+ + L+ L+A+EE
Sbjct: 1461 -DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAKEE----- 1508
Query: 582 LSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQEVE----- 633
L R N MLK ++ L + + D KN +L + T + + +++EL E++
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 634 --RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQFLSKELEH 679
RL++ ++ +K E DL +++ E R+ +ER + + +
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628
Query: 680 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT----EDL 735
++ +L +L + + K+L++ +A+ RE++ + E AT E
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
L+ D LQ+ L E + E E L +EL
Sbjct: 1689 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1724
Score = 119 bits (298), Expect = 2e-26
Identities = 147/632 (23%), Positives = 280/632 (44%), Gaps = 61/632 (9%)
Query: 132 QEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
QE + E+ +L+ + +E+ + S + L + + A+++ + I L + K+ +
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 187 EKSDEFICLLEQECERLKKLIDQEIKSQEEKE---QEKEKRVTTLKEELTKLKSFALMVV 243
+ + LE+ +R +K I+ + EEK + EK L++EL L ++ +
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDL 1443
Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQT 299
D Q++L + L +++K +L K +K A AEA +E+E KA L + L+
Sbjct: 1444 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503
Query: 300 -TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQDI 354
K ++ M K ED L + + + ELE++ R+L EE L+++
Sbjct: 1504 EAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 355 KEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 413
++++ E + ++ L+ + D++ +DE+ EE+ R L ++L + +D
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELEDE 1615
Query: 414 KLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
+ + +KL + LE D+ K ++E L K + K +ELE +
Sbjct: 1616 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDAR 1672
Query: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS--- 523
E+ A EK +L+ DL +L+ + ER L+K E + ASS
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 524 --QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE------ 575
LQ E+ ++ +L EE + + + +++ T++ + L N+L E
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 576 EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
E L R N L+++L +E K K+ + K Q + +E +
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE 694
LK K K +K I L++ EDE + E+ Y + +K K+L K +L + + +
Sbjct: 1851 LKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQRI 1903
Query: 695 TSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 726
++ + L + L E + + REV+ALK K+
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 85.5 bits (210), Expect = 3e-16
Identities = 114/542 (21%), Positives = 218/542 (40%), Gaps = 125/542 (23%)
Query: 136 YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICL 195
YE+ DK+ EK K ++ L L+V ++RQ + LE+++RK + L
Sbjct: 1415 YEEKAAAYDKL-EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ----------L 1463
Query: 196 LEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
L +E K D+ +++ E +EKE + +L L + AL +E +R L
Sbjct: 1464 LAEEKNISSKYADERDRAEAEA-REKETKALSLARALEE----ALEAKEELERTNKMLKA 1518
Query: 256 QRQKI------------------QELTTNAKETHTKLALAEARVQEEEQKATRLEKELQT 297
+ + + + L T +E T+L E +Q E RLE +Q
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1578
Query: 298 QTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE--------------------- 336
+F +D + A+ + + RQLQ++L ++++
Sbjct: 1579 LKGQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 337 -----------LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGK 385
EE + LRK + +++D + ++ I A +E K+ +E
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 386 DEEL---------------IKMEEQCRDLNKRLE-RETLQSKDFKLEV------EKLSKR 423
+L ++ EE +L L R LQ + +LE E+L +
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 424 IMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-------QLSQELESLKVRIKELE--- 473
+E + D K+ Q+ L L ER T + QL ++ + L+ ++ E+E
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Query: 474 ---------AIESRLEKTEF--------------TLKEDLTKLKTLTVMFVDERKTMSEK 510
A+E+++ + E +LK+ KLK + + DERK M+E+
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-MAEQ 1874
Query: 511 LKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK 570
K+ +K A QL+ + + ++++ ++ + + E ++ +E + LK+K
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Query: 571 LK 572
L+
Sbjct: 1935 LR 1936
Score = 62.8 bits (151), Expect = 2e-09
Identities = 75/370 (20%), Positives = 155/370 (41%), Gaps = 43/370 (11%)
Query: 80 EGELQARDEVIGILKAE-KMDLALLEAQYGFVTPKKVLEALQRDAFQA--KSTPWQEDIY 136
E +LQARDE + + + L E + ++ L A + + K Q D
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK----EYMEKSDEF 192
K E K + K + + +L A SR + +E ++K K + M+ ++
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 193 ICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
ER +K D E + E+ L++E +L++ + +E +
Sbjct: 1704 AA-----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 253 LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
+ ++++ T A++ +LA + Q+ E +LE++ + +K H+ + + +K
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 313 LTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDI-------------- 354
S L+ K+A L Q++ E + +SL++ +++L++I
Sbjct: 1819 F---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 355 KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
KE+ KG A V++L+++ +E +EE ++ R L + L+ T ++
Sbjct: 1876 KEQAEKGN-------ARVKQLKRQ---LEEAEEESQRINANRRKLQRELDEATESNEAMG 1925
Query: 415 LEVEKLSKRI 424
EV L ++
Sbjct: 1926 REVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 146 bits (368), Expect = 1e-34
Identities = 192/788 (24%), Positives = 345/788 (43%), Gaps = 137/788 (17%)
Query: 109 FVTPKKVLEAL-QRDAFQAKSTPWQE--DIYEKPMNELDKVVEKHKESYRRILGQLLVAE 165
F K +L+ Q + QAK Q+ + +K NEL ++ +KH + + L+ E
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQE 894
Query: 166 KSRRQTILELEEEKR------KHKEYMEKSDEFICLLEQECER-------LKKLIDQEIK 212
+ + +T L E E+ K +E E E LE+E +R KK+ Q +
Sbjct: 895 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 213 SQEEKEQEKEKRVTTLKEELT------KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
+E+ E+E+ R E++T KL+ L++ D+ +L+ + L ++I +LTTN
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014
Query: 267 AKETHTK--------------LALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTI 309
E K ++ E R+++EE+ LEK +L+ + FH+ +
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL 1074
Query: 310 MAKLTNEDSQNRQLQQKL-AALSRQIDELEETNRSLRKAEE---ELQDIKEKI------- 358
A++ Q + +++L AAL+R DE+ + N +L+K E + D++E +
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 359 SKGEYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFK 414
+K E + E+E L+ + LD +EL K E++ L K L+ ET +S + +
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET-RSHEAQ 1193
Query: 415 LE---------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE-- 463
++ VE+L++++ ++ + +K+KQ +L E Q QE+E
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 464 --SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
L+ +++EL++ S E+ L + + KL+ K K + +
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
SSQLQ Q E L EET++ K +V K+ + +ER+ L+++L E E +L
Sbjct: 1314 SSQLQDTQ-------ELLQEETRQ----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 582 LSRVNML-------KNRLQ----SLEAIE---KDFLK--NKLNQDSGKSTTALHQENNKI 625
++ L K +LQ ++EA+E K F K L Q + A +
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 626 KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL-------ERRYANERDKAQFLSKELE 678
L QE++ L + L + + + +L K + +++ L +YA+ERD+A+ ++E E
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 679 HVKMELAKYKLAEKTETSHE-------------------QWLFKRLQEEEAKSGHLSREV 719
+ LA+ L E E E + K + E E L ++
Sbjct: 1483 TKALSLAR-ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 720 DALKEKIH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENL 767
+ +K ++ E ATED L+ + LQ + Q E + R L R++
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 768 TKELERYR 775
ELE R
Sbjct: 1602 ETELEDER 1609
Score = 127 bits (319), Expect = 6e-29
Identities = 157/696 (22%), Positives = 302/696 (43%), Gaps = 86/696 (12%)
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
EK EL+K+ K + Q+ + + ++L +++ + + + + D+ I
Sbjct: 1047 EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK 1106
Query: 197 EQECERLKKL------IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
+++++L + +++ S+ + EK+ L EEL LK+ + D
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTA 1163
Query: 251 AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
Q L+ ++ QE+T K + EA+VQE QK + +EL Q +F + + +
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 311 AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
+ +N L +L L + E+E +K E ++Q+++ K S GE A +
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKK---KKLEAQVQELQSKCSDGERARAELND 1280
Query: 371 EVEELRKRV-------LDMEGKDEELIK----MEEQCRDLNKRLERETLQ-----SKDFK 414
+V +L+ V + EGK +L K + Q +D + L+ ET Q +K +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 415 LEVEKLSKRIMALEKLEDAFN-------------KSKQECYSLKCNLEKERMTTKQLSQE 461
LE E+ S + E++E N SK++ +E K+ +E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
+E+L + +E A +LEKT+ L+++L L V+ +D ++ + L+K + K
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDLDNQRQLVSNLEKKQRKF--- 1453
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
QL E+ +++ K +E RA + E K S+ + L+ L+A+EE
Sbjct: 1454 -DQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARA---LEEALEAKEE----- 1501
Query: 582 LSRVN-MLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQEVE----- 633
L R N MLK ++ L + + D KN +L + T + + +++EL E++
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 634 --RLKLKLKDMKA-IEDDLMKTEDEYETLERR-----------YANERDKAQFLSKELEH 679
RL++ ++ +K E DL +++ E R+ +ER + + +
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Query: 680 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMAT----EDL 735
++ +L +L + + K+L++ +A+ RE++ + E AT E
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
L+ D LQ+ L E + E E L +EL
Sbjct: 1682 AKSLEADLMQLQEDLAAAERARKQADLEKEELAEEL 1717
Score = 119 bits (298), Expect = 2e-26
Identities = 147/632 (23%), Positives = 280/632 (44%), Gaps = 61/632 (9%)
Query: 132 QEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
QE + E+ +L+ + +E+ + S + L + + A+++ + I L + K+ +
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 187 EKSDEFICLLEQECERLKKLIDQEIKSQEEKE---QEKEKRVTTLKEELTKLKSFALMVV 243
+ + LE+ +R +K I+ + EEK + EK L++EL L ++ +
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL----VVDL 1436
Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQKATRLEKELQTQT 299
D Q++L + L +++K +L K +K A AEA +E+E KA L + L+
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496
Query: 300 -TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE----LQDI 354
K ++ M K ED L + + + ELE++ R+L EE L+++
Sbjct: 1497 EAKEELERTNKMLKAEMED-----LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 355 KEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDF 413
++++ E + ++ L+ + D++ +DE+ EE+ R L ++L + +D
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ---NEEKRRQLQRQLHEYETELEDE 1608
Query: 414 KLE-------VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 466
+ + +KL + LE D+ K ++E L K + K +ELE +
Sbjct: 1609 RKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK---QLRKLQAQMKDFQRELEDAR 1665
Query: 467 VRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASS--- 523
E+ A EK +L+ DL +L+ + ER L+K E + ASS
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 524 --QLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE------ 575
LQ E+ ++ +L EE + + + +++ T++ + L N+L E
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 576 EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 634
E L R N L+++L +E K K+ + K Q + +E +
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 635 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE 694
LK K K +K I L++ EDE + E+ Y + +K K+L K +L + + +
Sbjct: 1844 LKQKDKKLKEI---LLQVEDERKMAEQ-YKEQAEKGNARVKQL---KRQLEEAEEESQRI 1896
Query: 695 TSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 726
++ + L + L E + + REV+ALK K+
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 85.5 bits (210), Expect = 3e-16
Identities = 114/542 (21%), Positives = 218/542 (40%), Gaps = 125/542 (23%)
Query: 136 YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICL 195
YE+ DK+ EK K ++ L L+V ++RQ + LE+++RK + L
Sbjct: 1408 YEEKAAAYDKL-EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ----------L 1456
Query: 196 LEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
L +E K D+ +++ E +EKE + +L L + AL +E +R L
Sbjct: 1457 LAEEKNISSKYADERDRAEAEA-REKETKALSLARALEE----ALEAKEELERTNKMLKA 1511
Query: 256 QRQKI------------------QELTTNAKETHTKLALAEARVQEEEQKATRLEKELQT 297
+ + + + L T +E T+L E +Q E RLE +Q
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQA 1571
Query: 298 QTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE--------------------- 336
+F +D + A+ + + RQLQ++L ++++
Sbjct: 1572 LKGQFERD---LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 337 -----------LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGK 385
EE + LRK + +++D + ++ I A +E K+ +E
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 386 DEEL---------------IKMEEQCRDLNKRLE-RETLQSKDFKLEV------EKLSKR 423
+L ++ EE +L L R LQ + +LE E+L +
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 424 IMALEKLEDAFNKSKQECYSLKCNLEKERMTTK-------QLSQELESLKVRIKELE--- 473
+E + D K+ Q+ L L ER T + QL ++ + L+ ++ E+E
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Query: 474 ---------AIESRLEKTEF--------------TLKEDLTKLKTLTVMFVDERKTMSEK 510
A+E+++ + E +LK+ KLK + + DERK M+E+
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERK-MAEQ 1867
Query: 511 LKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK 570
K+ +K A QL+ + + ++++ ++ + + E ++ +E + LK+K
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Query: 571 LK 572
L+
Sbjct: 1928 LR 1929
Score = 62.8 bits (151), Expect = 2e-09
Identities = 75/370 (20%), Positives = 155/370 (41%), Gaps = 43/370 (11%)
Query: 80 EGELQARDEVIGILKAE-KMDLALLEAQYGFVTPKKVLEALQRDAFQA--KSTPWQEDIY 136
E +LQARDE + + + L E + ++ L A + + K Q D
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK----EYMEKSDEF 192
K E K + K + + +L A SR + +E ++K K + M+ ++
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 193 ICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ 252
ER +K D E + E+ L++E +L++ + +E +
Sbjct: 1697 AA-----AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 253 LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
+ ++++ T A++ +LA + Q+ E +LE++ + +K H+ + + +K
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 313 LTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDI-------------- 354
S L+ K+A L Q++ E + +SL++ +++L++I
Sbjct: 1812 F---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 355 KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK 414
KE+ KG A V++L+++ +E +EE ++ R L + L+ T ++
Sbjct: 1869 KEQAEKGN-------ARVKQLKRQ---LEEAEEESQRINANRRKLQRELDEATESNEAMG 1918
Query: 415 LEVEKLSKRI 424
EV L ++
Sbjct: 1919 REVNALKSKL 1928
>gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]
Length = 639
Score = 145 bits (366), Expect = 2e-34
Identities = 90/299 (30%), Positives = 174/299 (58%), Gaps = 5/299 (1%)
Query: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD-- 122
E LS+ +LL L SILEGEL+ARD VI LKA+ D +E +YG L ALQRD
Sbjct: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRD-TFIEERYGKYNISDPLMALQRDFE 62
Query: 123 AFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH 182
+ K+ ++ + P++ L V+++ K R+L QL AE R+ IL+LEEE+++H
Sbjct: 63 TLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRH 122
Query: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
+ + D+ +LE+E ERL + ++ E ++ E+E++K + L+EE ++ K + M+
Sbjct: 123 AQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSML 182
Query: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 302
V E ++ T + + QK EL+ ++ ++++ E + E ++ + E +++ Q ++F
Sbjct: 183 VLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF 242
Query: 303 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 361
+++ + AKL E+++ + L++++ +L + + +LE +++ E+ + + +SKG
Sbjct: 243 DIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV--TVSKG 299
Score = 76.3 bits (186), Expect = 2e-13
Identities = 61/230 (26%), Positives = 115/230 (50%), Gaps = 17/230 (7%)
Query: 394 EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM 453
+QC+++ +R+ + ++ + K I+ LE+ + E + LEKER
Sbjct: 88 KQCKNMQERMLSQLAAAES------RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER- 140
Query: 454 TTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKK 513
++L+Q+LE K ++K+ E + +L L+E+ ++ K L+ M V E K + K +
Sbjct: 141 --ERLTQQLEFEKSQVKKFEKEQKKLSSQ---LEEERSRHKQLSSMLVLECKKATNKAAE 195
Query: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
K S +L+ E+++V+ + E+L E KR L+++ VE+++ ER+ L+ KL
Sbjct: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
Query: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEK-----DFLKNKLNQDSGKSTTAL 618
EE + L + LK ++ LEA + + LK + G +T L
Sbjct: 256 EENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPL 305
Score = 52.8 bits (125), Expect = 2e-06
Identities = 71/319 (22%), Positives = 143/319 (44%), Gaps = 22/319 (6%)
Query: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL--IEETKR 545
E L+K + LT+ + E + + L K Q + ++ K +++ L ++
Sbjct: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYN-ISDPLMALQRDFE 62
Query: 546 ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 605
LK K D EK T LK +K + +LS++ ++R + + ++ + +
Sbjct: 63 TLKEKND-GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKV-ILDLEEERQ 120
Query: 606 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
+ QD+ + + + + L+Q++E K ++K K E E + L +
Sbjct: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVK----------KFEKEQKKLSSQLEE 170
Query: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
ER + + LS L ++ + A K AE+ + + E L +L++E+++ L E+ A +++
Sbjct: 171 ERSRHKQLSSMLV-LECKKATNKAAEEGQKAGE--LSLKLEKEKSRVSKLEEELAAERKR 227
Query: 726 -IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 784
+ E + + L+ KLN++ENR + L E+E+L K + + S + S
Sbjct: 228 GLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIV---KDLEASHQHS 284
Query: 785 LNGRRISDPQVFSKEVQTE 803
++ P SK TE
Sbjct: 285 SPNEQLKKPVTVSKGTATE 303
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 134 bits (336), Expect = 6e-31
Identities = 172/782 (21%), Positives = 349/782 (44%), Gaps = 109/782 (13%)
Query: 80 EGELQARDEVIGILKAE--KMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYE 137
E ELQA+DE + +K + K++ L E + +K + L+ A+ + +++
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEME------RKHQQLLEEKNILAEQLQAETELFA 904
Query: 138 KPMNELDKVVEKHKESYRRILGQL--LVAEKSRRQTILELEEEKRKHKEYMEKSDEFICL 195
+ ++ K K+ IL L V E+ R IL+ EK+K + +++ +E +
Sbjct: 905 EAEEMRARLAAK-KQELEEILHDLESRVEEEEERNQILQ--NEKKKMQAHIQDLEEQL-- 959
Query: 196 LEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
E E ++ + E + E K ++ E+ + L+++ +K ++ D ++QL
Sbjct: 960 --DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 256 QRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK---ELQTQTTKFHQDQDTIMAK 312
+ +K + L + ++ E R+++EE+ LEK +L +TT + A+
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQ 1077
Query: 313 LTNEDSQNRQLQQKL-AALSRQIDELEETNRSLR----------KAEEELQDIKEKISKG 361
+ Q + +++L AL+R DE N +L+ + +E+ + K +K
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA 1137
Query: 362 EYGNAGIMAEVEELRKRV---LDMEGKDEEL-IKMEEQCRDLNKRLERETLQSKDFKLEV 417
E + E+E L+ + LD +EL K E++ +L K LE ET K+ + ++
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET---KNHEAQI 1194
Query: 418 EKLSKR-IMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE 476
+ + +R ALE+L + ++K+ K NLEK + + L + + L +K L+ ++
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKR----FKANLEKNK---QGLETDNKELACEVKVLQQVK 1247
Query: 477 SRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ------VEQN 530
+ E L + +L R ++EK K +++L S+ L+ ++
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFA 1307
Query: 531 KVTTVTEKLIEETKRALKSKT----DVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 586
K E +++T+ L+ +T ++ ++ + +E++ L+ + + EEE +L +V
Sbjct: 1308 KDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVL 1367
Query: 587 MLKNRL--------------QSLEAIEKDFLKN--KLNQDSGKSTTALHQENNKIKELSQ 630
L+++L +SLE +K LK+ L+Q + A + L Q
Sbjct: 1368 ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 631 EVERLKLKLKDMKAIEDDLMKTEDEYE-------TLERRYANERDKAQFLSKELEHVKME 683
E++ L + L + + +L K + +++ ++ RYA ERD+A+ ++E E +
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALS 1487
Query: 684 LAK-----YKLAEKTETSHEQW-------------LFKRLQEEEAKSGHLSREVDALKEK 725
LA+ + E+ E ++Q + K + E E L ++V+ ++ +
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 726 IH----EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENLTKELER 773
+ E ATED L+ + LQ + Q E + R L +++ L ELE
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 774 YR 775
R
Sbjct: 1608 ER 1609
Score = 130 bits (327), Expect = 7e-30
Identities = 185/837 (22%), Positives = 362/837 (43%), Gaps = 110/837 (13%)
Query: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAF 124
E+ +R +L L+GE + I L+A+ +L L A K E LQ
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA--------KKEEELQGALA 1097
Query: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
+ ++ K + EL + + +E + AEK +R ELE K + ++
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157
Query: 185 YMEKS---DEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTT----LKEELTKLKS 237
++ + E EQE LKK +++E K+ E + Q+ +R T L E+L + K
Sbjct: 1158 TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKR 1217
Query: 238 FALMVVDEQQ-------RLTAQLTLQRQ-------KIQELTTNAKETHTKLALAEARVQE 283
F + +Q L ++ + +Q K ++L +E H K++ + E
Sbjct: 1218 FKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE 1277
Query: 284 EEQKATRLEKELQTQTT----------KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQ 333
+KA++L+ EL +T KF +D ++ ++L + ++ ++ LS +
Sbjct: 1278 LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337
Query: 334 IDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKME 393
I +LEE SL++ +EE ++ ++ + K +V L+ ++ D + K ++ +
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEK----------QVLALQSQLADTKKKVDDDLGTI 1387
Query: 394 EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM 453
E + K+L KD + ++L ++ +A +KLE N+ +QE L +L+ +R
Sbjct: 1388 ESLEEAKKKL------LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441
Query: 454 TTKQLSQELESLKVRIKELEAIESRL----EKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
L ++ + + E ++I +R ++ E +E TK +L + + E
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLA-------RALEE 1494
Query: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
L+ E+ + + QL+ + + + + + + KSK +E+++ + + ++L++
Sbjct: 1495 ALEAKEE-FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
+L+A E+ L VNM Q+++A + L+ + Q+ K + Q EL
Sbjct: 1554 ELQATEDA--KLRLEVNM-----QAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 630 QEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL----- 684
E ++ L + K +E DL E + E + + + L +++ + EL
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 685 ------AKYKLAEKTETSHEQWLFKRLQEEEAKS----GHLSREVDALKEKI-------- 726
A+ K +EK S E + +LQEE A S H +E D L ++I
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEIL-QLQEELASSERARRHAEQERDELADEITNSASGKS 1725
Query: 727 ---HEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRP 783
E E I L+ + Q + +R R +++ L EL R + +
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER---SAAQK 1782
Query: 784 SLNGRRISDPQVFSKEVQTEAVDNE---PPDYKSLIPLERAVINGQLYEESENQDED 837
S N R+ + Q +KE++ + + E +K+ I A I GQL E+ E + ++
Sbjct: 1783 SDNARQQLERQ--NKELKAKLQELEGAVKSKFKATISALEAKI-GQLEEQLEQEAKE 1836
Score = 116 bits (290), Expect = 1e-25
Identities = 137/692 (19%), Positives = 308/692 (44%), Gaps = 74/692 (10%)
Query: 160 QLLVAEKSRRQT-----ILELEEEKRKHKEYMEKSDEF-------ICLLEQECERLKKLI 207
Q L+ E++R++ I +LEEEK +E E+ +E + L+ + KK +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 208 DQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNA 267
D ++ + E E+ K+K + + +L+ AL D+ ++ +L +Q++ +LT +
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL-AYDKLEKTKNRL---QQELDDLTVDL 1436
Query: 268 KETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
+ ++++++K +L E ++ + ++ +++D A+ ++++ L + L
Sbjct: 1437 DHQRQ----VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 328 AALSRQIDELEETNRSLRKAEEELQDIKEKISKG----EYGNAGIMAEVEELRKRVLDME 383
+E E N+ LR E+L K+ + K E + +VEE+R ++ ++E
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552
Query: 384 GK----DEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQ 439
+ ++ +++E + + + ER+ LQ++D E + KR++ + E
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERD-LQTRD---EQNEEKKRLLIKQVRE-------- 1600
Query: 440 ECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVM 499
L+ LE ER KQ + + S K +L+ +E+++E E + +L+ L
Sbjct: 1601 ----LEAELEDER---KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 500 FVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYS 559
D ++ + E+ + + D++ A S + + + + +L EE + +++ E++
Sbjct: 1654 MKDYQREL-EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712
Query: 560 VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ----SLEAIEKDFLK-----NKLNQD 610
+ E + + A ++ L +R+ L+ L+ ++E + F K + LN +
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772
Query: 611 SGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT-----EDEYETLERRYAN 665
+A + +N ++L ++ + LK KL++++ K E + LE +
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
E + +K + + +L + + + E H +++++ A+ L R+++ +E+
Sbjct: 1833 EAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEE 1892
Query: 726 IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
A+ LQ++L+ N L RE+ L L R S S S
Sbjct: 1893 ATRANASR----------RKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFS--SSR 1940
Query: 786 NGRRISDPQVFSKEVQTEAVDNEPPDYKSLIP 817
+GRR + S E+ + +++ D P
Sbjct: 1941 SGRRQLHLEGASLELSDDDTESKTSDVNETQP 1972
Score = 110 bits (276), Expect = 6e-24
Identities = 131/615 (21%), Positives = 275/615 (44%), Gaps = 57/615 (9%)
Query: 210 EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQ---ELTTN 266
++ QEE+ Q K++ + +KE+ TK++ + + Q+L + + +++Q EL
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 267 AKETHTKLAL-----------AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTN 315
A+E +LA E+RV+EEE++ + LQ + K + +L
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEER----NQILQNEKKKMQAHIQDLEEQLDE 961
Query: 316 EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
E+ ++LQ + +I ++EE L + K+ + + +AE EE
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 376 RKRVLDMEGKD-------EELIKMEEQCR-DLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
K + + K EE +K EE+ R +L K + ++ D + ++ +L +I
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI--- 1078
Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------AIESRLE 480
++L+ K ++E + E + + + L+ +I EL+ A ++ E
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 481 KTEFTLKEDLTKLKTL------TVMFVDERKTMSE----KLKKT-EDKLQAASSQLQVEQ 529
K + L E+L LKT T E +T E +LKK E++ + +Q+Q +
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 530 NKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK 589
+ T E+L E+ ++A + K ++E+ + + +L ++K ++ + + L
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 590 NRLQSLEA--IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL-KDMKAIE 646
++Q L A E D L+ +L + + K L E + + L +E E+ +K KD ++E
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASK----LQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 647 DDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQ 706
L T++ + R+ N + + L +E ++ + + + A K L +L
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 707 EEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIEN 766
+ + K +++L+E + + + + + ++ KL + +NR L +E+++
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR---LQQELDD 1431
Query: 767 LTKELERYRHFSKSL 781
LT +L+ R + +L
Sbjct: 1432 LTVDLDHQRQVASNL 1446
Score = 108 bits (270), Expect = 3e-23
Identities = 112/526 (21%), Positives = 237/526 (45%), Gaps = 65/526 (12%)
Query: 82 ELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMN 141
+L A ++ I AE+ D A EA+ + AL+ +A +AK +E+
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE-EALEAKEE------FERQNK 1507
Query: 142 ELDKVVEKHKESYRRILGQLLVAEKSRR---QTILELEEEKRKHKEYMEKSDEFICLLEQ 198
+L +E S + + EKS+R Q + E+ + + ++ ++ +++ LE
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 199 ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQ 258
+ +K ++++++++E+ +EK++ +++ + + L A+L +R+
Sbjct: 1568 NMQAMKAQFERDLQTRDEQNEEKKR-----------------LLIKQVRELEAELEDERK 1610
Query: 259 KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKEL---QTQTTKFHQDQDTIMAKLTN 315
+ + K+ L EA+++ + + K+L Q Q + ++ + A
Sbjct: 1611 QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDE 1670
Query: 316 EDSQNRQLQQKLAALSRQI----DELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
+Q+++ ++KL +L +I +EL + R+ R AE+E ++ ++I+ G + ++ E
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 372 VEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
L R+ +E EEL + + LN R + TLQ E L+ A +K +
Sbjct: 1731 KRRLEARIAQLE---EELEEEQSNMELLNDRFRKTTLQVDTLNAE---LAAERSAAQKSD 1784
Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-AIESRLEKTEFTLKEDL 490
+A +QL ++ + LK +++ELE A++S+ + T L+ +
Sbjct: 1785 NA---------------------RQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 491 TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSK 550
+L+ ER ++ +++TE KL+ Q++ E+ E++ + R + K
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Query: 551 TDVEEKMYSVTK---ERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ 593
+EE T+ R L+ +L E L V+ LKNRL+
Sbjct: 1884 RQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 99.0 bits (245), Expect = 2e-20
Identities = 117/571 (20%), Positives = 245/571 (42%), Gaps = 74/571 (12%)
Query: 310 MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIM 369
+ ++T ++ + + ++L + + ++E + + ++L + K +++ +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 370 AEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK 429
AE EE+R R + K +EL EE DL R+E E +++ + E +K+ I LE+
Sbjct: 904 AEAEEMRAR---LAAKKQEL---EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 430 LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVR------IKELEAIESRLEKTE 483
D ++Q K LEK K E E L + IKE + +E R+ +
Sbjct: 958 QLDEEEGARQ-----KLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 484 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEET 543
L E+ K K L K +K + S L+ E+ K T + +E+
Sbjct: 1013 SQLAEEEEKAKNLA---------------KIRNKQEVMISDLE-ERLKKEEKTRQELEKA 1056
Query: 544 KRALKSK-TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN----MLKNRLQSLEAI 598
KR L + TD+++++ + + D+LK +L +EE+ L+R + N L+ + +
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 599 EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD----------------- 641
+ +L +D + ++ + ++LS+E+E LK +L+D
Sbjct: 1117 QAQIA--ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174
Query: 642 -----MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETS 696
KA+E++ E + + + +R+A ++ ++ + K L K K +T+
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234
Query: 697 HEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLI--------CHLQGDHSVLQK 748
K LQ+ +A+S H +++DA +++H ++ D + LQ + +
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 749 KLNQQENRNRDLGREIENLTKELERYRH-FSKSLRPSLN-GRRISDPQVFSKEVQTEAVD 806
L + E + ++ +L +L+ + + R LN RI + +Q + +
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 807 NEPPDYKSLIPLERAVINGQLYEESENQDED 837
E + + + + + QL + + D+D
Sbjct: 1355 EE--EARKNLEKQVLALQSQLADTKKKVDDD 1383
Score = 65.1 bits (157), Expect = 4e-10
Identities = 80/336 (23%), Positives = 141/336 (41%), Gaps = 47/336 (13%)
Query: 79 LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEK 138
LE E + R + K ++DL LEAQ + Q QA+ +Q ++ E
Sbjct: 1605 LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA 1664
Query: 139 PMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ 198
+ D++ + KES +++ + L AE + Q L E R+H E ++ DE +
Sbjct: 1665 RASR-DEIFAQSKESEKKL--KSLEAEILQLQEELASSERARRHAE--QERDELADEITN 1719
Query: 199 ECERLKKLIDQEIK-----SQEEKEQEKEK---------------RVTTLKEELTKLKSF 238
L+D++ + +Q E+E E+E+ +V TL EL +S
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779
Query: 239 ALMVVDEQQRLTAQLTLQRQKIQELTTNAKET--------HTKLALAEARVQEEEQKATR 290
A + +Q+L Q + K+QEL K K+ E ++++E ++
Sbjct: 1780 AQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAA 1839
Query: 291 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQ---KLAALSRQIDELEE----TNRS 343
K ++ K + + + + D Q+++ ++ L RQ++E EE N S
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 344 LRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRV 379
RK + EL D E N G+ EV L+ R+
Sbjct: 1900 RRKLQRELDDATE-------ANEGLSREVSTLKNRL 1928
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 132 bits (332), Expect = 2e-30
Identities = 185/778 (23%), Positives = 325/778 (41%), Gaps = 152/778 (19%)
Query: 132 QEDIYEKPMNELDKVVEKHKESYRRI-----LGQLLVAEKSRRQTILELEEE-------- 178
QE+ EL KV EK + R+ L L+AEK + Q L+ E E
Sbjct: 843 QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902
Query: 179 ----KRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQ----------EEKEQEKEK- 223
K +E E + +E+E ER + L ++ K Q EE+E ++K
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 224 ---RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEAR 280
+VTT + +L KL+ +++ D+ +L + L +I E TTN E K
Sbjct: 963 QLEKVTT-EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 281 VQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEET 340
+ E T LE+ L+ + K Q+ + KL + + L ++A L QI EL+
Sbjct: 1022 KNKHEAMITDLEERLRRE-EKQRQELEKTRRKL---EGDSTDLSDQIAELQAQIAELK-- 1075
Query: 341 NRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVL----DMEGKDEELIKMEEQC 396
L K EEELQ ++ + + ++ EL ++ D+E + K E+Q
Sbjct: 1076 -MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQK 1134
Query: 397 RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT-- 454
RDL + LE K E+E A ++L +K +QE LK LE+E T
Sbjct: 1135 RDLGEELEA-------LKTELEDTLDSTAAQQELR---SKREQEVNILKKTLEEEAKTHE 1184
Query: 455 ------TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMS 508
++ SQ +E L ++++ + +++ LEK + TL+ + +L + + +
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 509 EKLKKTEDKLQAAS-----------------SQLQVEQNKVT-----------------T 534
K KK E +LQ ++LQVE + VT +
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 535 VTEKLIEETKRAL----KSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRV----- 585
E +++T+ L + K + K+ V E++ + +L+ EEE ++L ++
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 586 ---NMLKNRLQSLEAIE-KDFLKNKLNQD------SGKSTTALHQENNKIK-ELSQEVER 634
+M K S+ +E + +K KL +D + A + + K K L QE++
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 635 LKLKLKDMKAIEDDLMKTEDEYE-------TLERRYANERDKAQFLSKELEHVKMELAK- 686
L + L + +L K + +++ T+ +YA ERD+A+ ++E E + LA+
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA 1484
Query: 687 -----------YKLAEKTETSHEQWLF------KRLQEEEAKSGHLSREVDALKEKIH-- 727
+L ++ T E + K + E E L ++V+ +K ++
Sbjct: 1485 LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 728 --EYMATEDLICHLQGDHSV--------LQKKLNQQENRNRDLGREIENLTKELERYR 775
E ATED L+ + LQ + Q E + + L R++ + ELE R
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Score = 128 bits (322), Expect = 3e-29
Identities = 163/777 (20%), Positives = 330/777 (42%), Gaps = 98/777 (12%)
Query: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAF 124
E+ R +L LEG+ + I L+A+ +L + A K E LQ
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA--------KKEEELQAALA 1090
Query: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
+ + Q+++ K + EL+ + + +E AEK +R ELE K + ++
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 185 YMEKS---DEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKR----VTTLKEELTKLKS 237
++ + E EQE LKK +++E K+ E + QE ++ V L E+L + K
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
Query: 238 FALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEE------------ 285
+ +Q L + +++ L ++ K EA++QE +
Sbjct: 1211 VKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTE 1270
Query: 286 --QKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE----LEE 339
K T+L+ EL D + L+ DS++ +L + +AL Q+ + L+E
Sbjct: 1271 LADKVTKLQVEL-----------DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319
Query: 340 TNR-------SLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM 392
NR L++ E+E +E++ + E + ++ L +V DM+ K E+ +
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 393 EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL-------- 444
E ++ ++L+ KD + ++ +++ A +KLE + +QE L
Sbjct: 1380 LETAEEVKRKLQ------KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR 1433
Query: 445 --KCNLEKERMTTKQLSQELESL-------------KVRIKELEAIE-SRLEKTEFTLKE 488
CNLEK++ QL E +++ + R KE +A+ +R + K
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA 1493
Query: 489 DLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALK 548
+L +L +++ + + + K+ +L+ + L+ + ++ T E+L +E +
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 549 SKTDVEEKMYSVTKERD-DLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF---LK 604
+K +E + ++ + + DL+ + + EEK L+ +V ++ L+ E ++ +
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED-ERKQRSMAVAAR 1612
Query: 605 NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD-MKAIEDDLMKTEDEYETLERRY 663
KL D + N E +++ +L+ ++KD M+ ++D E E L +
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE---EILAQAK 1669
Query: 664 ANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSG-------HLS 716
NE+ K + + E+ ++ ELA + A++ L + K L
Sbjct: 1670 ENEK-KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 717 REVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 773
+ L+E++ E +LI ++ ++N N R ++ EN ++LER
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER 1785
Score = 127 bits (318), Expect = 8e-29
Identities = 151/652 (23%), Positives = 284/652 (43%), Gaps = 83/652 (12%)
Query: 123 AFQAKSTPWQEDIYEKPMNELD-----KVVEKHKESYRRILGQLLVAEKSRRQTILELEE 177
A +++ QE + E+ +L K VE K S+R L + A+ + + I L
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 178 EKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEK-------EKRVTTLKE 230
+ K+ ME D CL + E +K+ + ++++ ++ +EK EK T L++
Sbjct: 1365 QVADMKKKME--DSVGCL--ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420
Query: 231 ELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA----LAEARVQEEEQ 286
EL L L+ +D Q++ L +++K +L K K A AEA +E+E
Sbjct: 1421 ELDDL----LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET 1476
Query: 287 KATRLEK----------ELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
KA L + EL+ +F + + +M+ + +L++ AL +Q++E
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536
Query: 337 LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 396
++ L + E+ELQ ++ + E + A+ E D++G+DE+ + ++Q
Sbjct: 1537 MKT---QLEELEDELQATEDAKLRLEVNLQAMKAQFER------DLQGRDEQSEEKKKQL 1587
Query: 397 ----RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKER 452
R++ LE E Q +KL + LE D+ NK++ E L K +
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK---QLRKLQ 1644
Query: 453 MTTKQLSQEL-------ESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERK 505
K +EL E + + KE E +E L+E+L + ER
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704
Query: 506 TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTD-VEEKMYSVTKER 564
+++++ + K A + + + ++ + E+L EE + T+ + +++ +
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE-----QGNTELINDRLKKANLQI 1759
Query: 565 DDLKNKLKAEE------EKGNDLLSRVNM-LKNRLQSLEAIEKDFLKNKLNQDSGKSTTA 617
D + L E E L R N LK +LQ +E K K + K
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 618 LHQENNKIKELS---QEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLS 674
Q +N+ KE ++V R + KLKD+ L++ +DE E +Y ++ DKA S
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDV------LLQVDDERRNAE-QYKDQADKA---S 1869
Query: 675 KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 726
L+ +K +L + + + + + L + L++ + ++REV +LK K+
Sbjct: 1870 TRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 116 bits (290), Expect = 1e-25
Identities = 168/751 (22%), Positives = 317/751 (42%), Gaps = 124/751 (16%)
Query: 175 LEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQE-IKSQEEKEQEKEKRVTTLKEELT 233
L + R+ +E M K +E + + E++ +L + E ++SQ E+ + + + EL
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 234 KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK 293
E + L A+LT ++Q+++E+ + EARV+EEE++ +
Sbjct: 897 A----------EAEELRARLTAKKQELEEICHDL----------EARVEEEEERC----Q 932
Query: 294 ELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQD 353
LQ + K Q+ + +L E+S ++LQ E T L+K EEE
Sbjct: 933 HLQAEKKKMQQNIQELEEQLEEEESARQKLQL----------EKVTTEAKLKKLEEEQII 982
Query: 354 IKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQ 409
++++ K + + E + + E K + L K+ E DL +RL RE Q
Sbjct: 983 LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 410 SKDF-----KLEVEK--LSKRIMALE----KLEDAFNKSKQECYSLKCNLEKERMTTKQL 458
++ KLE + LS +I L+ +L+ K ++E + +E+E
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102
Query: 459 SQELESLKVRIKELE-------AIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEK- 510
+++ L+ +I EL+ A ++ EK + L E+L LKT +D E
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR 1162
Query: 511 ---------LKKT-EDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSV 560
LKKT E++ + +Q+Q + K + E+L E+ ++ + K ++E+ ++
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222
Query: 561 TKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEA--------------------IEK 600
ER +L N++K + D + ++ +LQ L+ +E
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 601 DFLKNKLNQDSGKST------TALHQENNKIKELSQEVERLKLKLK-DMKAIEDD----- 648
D + L+Q KS+ +AL + +EL QE R KL L +K +ED+
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342
Query: 649 --LMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQ 706
L + E+ LE++ A + + K++E L + ++ + L +R +
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 707 EEEAKSGHLSREVDALKEKIHEYMATED----LICHLQGDHSVLQKKLNQQ--------E 754
E+ A L + L++++ + + D C+L+ + L ++ E
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 755 NRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVD---NEPPD 811
R+R E TK L R +++ R+ +K+ +TE D ++
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERL------NKQFRTEMEDLMSSKDDV 1516
Query: 812 YKSLIPLERAV-INGQLYEESENQDEDPNDE 841
KS+ LE++ Q EE + Q E+ DE
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547
Score = 92.0 bits (227), Expect = 3e-18
Identities = 104/506 (20%), Positives = 228/506 (45%), Gaps = 46/506 (9%)
Query: 82 ELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMN 141
+L A ++ I AE+ D A EA+ + AL+ +A + K+ E + ++
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE-EAMEQKAE--LERLNKQFRT 1504
Query: 142 ELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECE 201
E++ ++ K+ + + +L ++++ Q + E++ + + ++ ++ +++ LE +
Sbjct: 1505 EMEDLMSS-KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQ 1563
Query: 202 RLKKLIDQEIKSQEEKEQEKEKR----VTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
+K +++++ ++E+ +EK+K+ V ++ EL + M V +++L L
Sbjct: 1564 AMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 258 QKIQELTTNAKETHTKLALAEARVQE--EEQKATRLEKELQTQTTKFHQDQDTIMAKLTN 315
I N E +L +A++++ E TR +E K ++ KL +
Sbjct: 1624 AHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK------KLKS 1677
Query: 316 EDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
+++ QLQ++LAA R+ R+A++E ++ ++I+ A + E L
Sbjct: 1678 MEAEMIQLQEELAA----------AERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 376 RKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ----SKDFKLEVEKLSKRIMALEKLE 431
R+ +E EEL + + +N RL++ LQ + D LE K A ++LE
Sbjct: 1728 EARIAQLE---EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784
Query: 432 DAFNKSKQECYSLKCNLEKERMTT-----KQLSQELESLKVRIKELEAIESRLEKTEFTL 486
+ K + ++ ++ + + +++Q E L KE +A ++ +TE L
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKL 1844
Query: 487 KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRA 546
K+ L + VD+ + +E+ K DK QL+ + + ++ ++
Sbjct: 1845 KDVLLQ--------VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKL 1896
Query: 547 LKSKTDVEEKMYSVTKERDDLKNKLK 572
+ D E ++ +E LKNKL+
Sbjct: 1897 QRELEDATETADAMNREVSSLKNKLR 1922
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 132 bits (331), Expect = 2e-30
Identities = 173/718 (24%), Positives = 325/718 (45%), Gaps = 100/718 (13%)
Query: 114 KVLEALQRDAFQAKSTPWQEDIYEKPMNELD--KVVEKHKESYRRILGQLLVAEKSRRQT 171
K+ E D F+A ++D + ++E+ K + KH E Y + L L S+ +
Sbjct: 527 KLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENEL---SSKVEL 583
Query: 172 ILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEE 231
+ E E++ +K +EY++ Q+ E +K + ++S E+ +Q +K+
Sbjct: 584 LREKEDQIKKLQEYIDS---------QKLENIKMDLSYSLESIEDPKQ--------MKQT 626
Query: 232 LTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRL 291
L ++ AL E L ++ ++K++EL T K+ + L +++++ +++ L
Sbjct: 627 LFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDL 686
Query: 292 EKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
EKELQ+ + + I K+ + N +L+ K+ L +++++ E N +LR+ L
Sbjct: 687 EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746
Query: 352 QDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSK 411
++K + +EVE LRK + D K EEL + + L + + + +
Sbjct: 747 SELK-----------SLPSEVERLRKEIQD---KSEELHIITSEKDKLFSEVVHKESRVQ 792
Query: 412 DFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLE-KERMT---TKQLSQELESLKV 467
E+ K + + + ++ Q +L + E K +M ++++QE+ +L
Sbjct: 793 GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS- 851
Query: 468 RIKELEAIESRLE--KTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
KE + +S L KTE + K + KT V ER E+LK ++L+ S L
Sbjct: 852 --KEAQKFDSSLGALKTELSYKTQELQEKTRE---VQERLNEMEQLK---EQLENRDSTL 903
Query: 526 QVEQNKVTTVTEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLL 582
Q + + T +TEKL +EE K + K D+++ S+ ERD LK+ + + N +
Sbjct: 904 QTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI---HDTVNMNI 960
Query: 583 SRVNMLKNRLQSLEAIEK--DFLKNKLNQDSGKSTTALHQENNKIK---ELSQEV----E 633
L+N L+SL+ ++ + LK+K++++ ++ LH E N + E Q++ +
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRN---LHMEENTGETKDEFQQKMVGIDK 1017
Query: 634 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHV--KMELAKYKLAE 691
+ L+ K+ + + D+ ++E +R+ + + L + LE V + E K L E
Sbjct: 1018 KQDLEAKNTQTLTADV--KDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 692 KTETSHEQWLFKRLQEEE----------------AKSGHLSREVD-------ALKEKIHE 728
E + E RL +E K G LSR D LKEK +
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135
Query: 729 YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLN 786
+ + ++Q + S +QKK+N+ EN L E++N LE L LN
Sbjct: 1136 LQEKQQQLLNVQEEMSEMQKKINEIEN----LKNELKNKELTLEHMETERLELAQKLN 1189
Score = 118 bits (295), Expect = 4e-26
Identities = 182/850 (21%), Positives = 370/850 (43%), Gaps = 144/850 (16%)
Query: 76 LSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPK--KVLEALQRDAFQAKSTPWQE 133
L +L EL+ + E++ EK E + + +V E L+ + Q + Q
Sbjct: 1087 LRLLGDELKKQQEIVA---QEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQL 1143
Query: 134 DIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFI 193
++ M+E+ K + + + + K++ T+ +E E+ + + + ++ E +
Sbjct: 1144 LNVQEEMSEMQKKINEIENLKNEL--------KNKELTLEHMETERLELAQKLNENYEEV 1195
Query: 194 CLLEQECERLKKLIDQ-EIKSQEEKEQEKEKRVTTL--KEELTKLKSFALM----VVDEQ 246
+ +E + LK+L E + + +E T L KEEL K+ L +DE
Sbjct: 1196 KSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEEL-KIAHIHLKEHQETIDEL 1254
Query: 247 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
+R ++ T Q Q+L +++HTKL + EE++ +++ +TQ T +
Sbjct: 1255 RRSVSEKTAQIINTQDL----EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETM--NEL 1308
Query: 307 DTIMAKLTNEDSQN-RQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN 365
+ + + T +DS +++ + L+ + E +E +SL K + L+ IKE + E +
Sbjct: 1309 ELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL---EVKH 1365
Query: 366 AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRL-ERETLQSKD---FKLEVEKL- 420
+ + E ++ + + K E+ + M+E+ + K + E E + KD ++E+E L
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG 1425
Query: 421 -SKRIMA--------------LEKLEDAFN------------------KSKQECYSLKCN 447
SKR+ L++L++ ++++E C
Sbjct: 1426 LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC 1485
Query: 448 LEKERMTTKQLSQELESLKVRI----KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDE 503
L+++ T +L L + I K+LEAI +L+ ++E K + + + E
Sbjct: 1486 LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQN---KIQEIYEKEEQFNIKQISE 1542
Query: 504 RKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL---IEETKRALKSKTDVEEKMYSV 560
+ +LK+ ++ +A S LQ ++K+ +T +L EE + +K K +++ ++
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602
Query: 561 TKERDDLKN-------KLKAEEEKGNDLL--SRVNMLKNRLQSLEAIEKDFLKNKLNQDS 611
ERD LK K+K +EK L + VN + ++ +E +++ F KLN ++
Sbjct: 1603 QIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 612 GKS-----TTALHQENNKIKELSQE------------VERLKLKLKDMKAIEDDLMKTE- 653
++ T LH+ +++ +++E VER +LK + I DL K E
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEE 1722
Query: 654 ---------DEYETLERRYANERDKAQFLS---KELEHVK--MELAKYKLAEKTETSH-- 697
+ ET+++ +K +S K+LEH ++ K+ E+ +H
Sbjct: 1723 LKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMH 1782
Query: 698 ---EQWLFKRLQ----EEEAKSGHLSREVD----ALKEKIHEYMATEDLICHLQGDHSVL 746
+Q +L+ E+ K ++ ++++ L+EKI E A E + L+ D +
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNET 1842
Query: 747 QKKLNQQENRNRDL--------GREIENLT---KELERYRHFSKSLRPSLNGRRISDPQV 795
QKK+++ E + + EIENL K E ++ N RR+ +
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
Query: 796 FSKEVQTEAV 805
++ E++
Sbjct: 1903 LERDQLKESL 1912
Score = 108 bits (271), Expect = 2e-23
Identities = 162/798 (20%), Positives = 353/798 (44%), Gaps = 96/798 (12%)
Query: 79 LEGELQARDEVIGILKAE------KMDLALLEAQYGFVTPKKVLEALQ-RDAFQAKSTPW 131
L E Q D +G LK E ++ E Q +++ E L+ RD+
Sbjct: 850 LSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVERE 909
Query: 132 QEDIYEKPMNELDKV--VEKHKESYRRILGQLLVAEKSRRQTI-------LELEEEKRKH 182
+ I EK L++V + + K+ +++ L + + I ++ +E+ R
Sbjct: 910 KTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNA 969
Query: 183 KEYMEKSDEFICLLEQEC-ERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALM 241
E +++ E I L+ + E + + + E + E K++ ++K V K++ + K+ +
Sbjct: 970 LESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029
Query: 242 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTK 301
D + ++ Q++KI L E L E+ + E+EQ T L++ ++ T +
Sbjct: 1030 TADVKDN---EIIEQQRKIFSLIQEKNELQQML---ESVIAEKEQLKTDLKENIE-MTIE 1082
Query: 302 FHQDQDTIMAKLTNEDS----QNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 357
++ + +L + + +K LSR D L E L++ ++LQ+ +++
Sbjct: 1083 NQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQ 1142
Query: 358 ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDL-NKRLERETLQSKDFKLE 416
+ + E+ E++K++ ++E EL E + +RLE +++++ E
Sbjct: 1143 L-------LNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYE-E 1194
Query: 417 VEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAI- 475
V+ ++K L++L+ +F + L+ + + T Q +EL+ + +KE +
Sbjct: 1195 VKSITKERKVLKELQKSFETERDH---LRGYIREIEATGLQTKEELKIAHIHLKEHQETI 1251
Query: 476 -ESRLEKTEFT--------LKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQ 526
E R +E T L++ TKL+ + +E++ + + +E + +L
Sbjct: 1252 DELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELL 1311
Query: 527 VEQN--KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSR 584
EQ+ K +T ++ E R + + +E++ S+TKERD+LK +A E K + L
Sbjct: 1312 TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH 1371
Query: 585 VNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL----K 640
+ ++Q ++ ++ L K + TT + E + K + R+++++ K
Sbjct: 1372 IRETLAKIQESQSKQEQSLNMK---EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK 1428
Query: 641 DMKAIEDDL---MKTEDEYETLERRYANERDK-----AQFLSKELE-HVKMELAKYKLAE 691
++ D++ K +D+ + L+ +E D+ + ++K LE ++++A L E
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488
Query: 692 KTETSHEQWLFKRLQEEEAKSGHLSREVDA----LKEKIHEYMATEDLIC---------- 737
+ ET +E L L E+E + + ++++A L+ KI E E+
Sbjct: 1489 QEETINE--LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546
Query: 738 ---------HLQGDHSVLQ---KKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
H + S LQ K+ + NR ++ EI+ + KE E + ++L+
Sbjct: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606
Query: 786 NGRRISDPQVFSKEVQTE 803
+ + + ++ +K +++
Sbjct: 1607 DQLKENTKEIVAKMKESQ 1624
Score = 107 bits (268), Expect = 5e-23
Identities = 154/723 (21%), Positives = 316/723 (43%), Gaps = 97/723 (13%)
Query: 117 EALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELE 176
E Q + KS + D + L+ ++ KE R L ++ ++ + Q++ E
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE 1394
Query: 177 EEKRKHK-----EYMEKSDEFICLLEQECERLKKLIDQ---EIKSQEEKEQEKEKRVTTL 228
++ K E + D + +E E L K + + E+KS +++ + ++ L
Sbjct: 1395 KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVL 1454
Query: 229 KEELTKLKSFALMVVDEQQRLTAQLTL-------QRQKIQELTTNAKETHTKLALAEARV 281
+ E +LK +V + +L + Q + I EL N E T+++ + ++
Sbjct: 1455 QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQL 1514
Query: 282 QEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE--LEE 339
+ K +E+ + +F+ Q + + + NE Q ++ ++ + + I+ LE
Sbjct: 1515 EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574
Query: 340 TNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDL 399
TNR L++++EE+Q IM + +E KRV E E +++E +++
Sbjct: 1575 TNR-LQESQEEIQ---------------IMIKEKEEMKRV--QEALQIERDQLKENTKEI 1616
Query: 400 NKRLERETLQSKDFKL----EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 455
+++ Q K+++ V + +++ +E L++ F K N+E E +
Sbjct: 1617 VAKMKES--QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLE----NIETENIRL 1670
Query: 456 KQLSQE-LESLKVRIKE---LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKL 511
Q+ E LE ++ KE L ++E L+ LKE+L + T + +E K + L
Sbjct: 1671 TQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730
Query: 512 KKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKT-DVEEKM---YSVTKERDDL 567
K+ ++ + + + N+++ + +K +E + ALK++ ++E++ + KE+ +
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNM-QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
Query: 568 KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKE 627
+KL+ + D LS NM K+ S +++ + K N+ L ++ N+ ++
Sbjct: 1790 IDKLRGIVSEKTDKLS--NMQKDLENSNAKLQEKIQELKANEHQ---LITLKKDVNETQK 1844
Query: 628 LSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKY 687
E+E+LK ++KD L K E E L ++ ++ + + KE ++++
Sbjct: 1845 KVSEMEQLKKQIKDQSLT---LSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR----- 1896
Query: 688 KLAEKTETSHEQWLFKRLQEEEAKSGHLSRE--------------VDALKEKIHE-YMAT 732
E+T L + LQE +A+ + +E VD L+EKI E +
Sbjct: 1897 --VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQI 1954
Query: 733 EDLICHLQGDHSVLQKKLNQQENRNRDLGR-------------EIENLTKELERYRHFSK 779
D+ L LQKK+ + + + L R E+E L K+ E +
Sbjct: 1955 SDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ 2014
Query: 780 SLR 782
S+R
Sbjct: 2015 SVR 2017
Score = 86.7 bits (213), Expect = 1e-16
Identities = 131/635 (20%), Positives = 289/635 (45%), Gaps = 91/635 (14%)
Query: 210 EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKE 269
E+ + E + K + LK++L ++ E+ +L AQL ++ +Q++ E
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQL-AQLLEEKDLLQKVQNEKIE 395
Query: 270 THTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAA 329
T++ + + + +++ + ++ + K ++ +++ A N + KL+
Sbjct: 396 NLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLS- 454
Query: 330 LSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA-------GIMAEVEELR----KR 378
I+ L E + S+ + + + +S+ E+ A I +E+ LR
Sbjct: 455 ----INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNL 510
Query: 379 VLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKL---EDAFN 435
VLD E E +ME + ++ N E E L+ K K + +L I L+ L + +N
Sbjct: 511 VLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYN 570
Query: 436 KSKQECYSLKCNLEKERM-TTKQL-----SQELESLKVRIK-ELEAIE--SRLEKTEF-- 484
+ + S K L +E+ K+L SQ+LE++K+ + LE+IE ++++T F
Sbjct: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
Query: 485 -----TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQ---------- 529
K + L++ + ++ K ++ K+ E+ +Q SQL+ ++
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
Query: 530 ----NKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRV 585
N++T +T + + + L ++E K+ DL+ +L E E+ N+ L
Sbjct: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELEGKI-------TDLQKELNKEVEE-NEALREE 742
Query: 586 NMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI-KELSQEVERLKLKLKDMKA 644
+L + L+SL + E + L+ ++ QD + + E +K+ E+ + R++ L+++
Sbjct: 743 VILLSELKSLPS-EVERLRKEI-QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 645 IEDDLMKTEDEYETLERRYANER--------------DKAQFLSKELEHVKMELAKYKL- 689
+DDL T+ Y++ ++ + N + ++ + +++E+ ++ E K+
Sbjct: 801 TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860
Query: 690 --AEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQ 747
A KTE S++ + LQE+ + E++ LKE++ +T + + + +++
Sbjct: 861 LGALKTELSYKT---QELQEKTREVQERLNEMEQLKEQLENRDSTLQTV---EREKTLIT 914
Query: 748 KKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 782
+KL Q E++ LT+E + + +SL+
Sbjct: 915 EKLQQTL-------EEVKTLTQEKDDLKQLQESLQ 942
Score = 85.1 bits (209), Expect = 3e-16
Identities = 157/782 (20%), Positives = 335/782 (42%), Gaps = 144/782 (18%)
Query: 63 QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
+A+D + + + L LQ E I I+ EK ++ K+V EALQ +
Sbjct: 1558 KAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEM------------KRVQEALQIE 1605
Query: 123 AFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH 182
Q K E + K+ E ++ Y+ + + + + I L+E+
Sbjct: 1606 RDQLK---------ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQ 1656
Query: 183 KEYMEKSD----EFICLLEQECERLKKLIDQ--EIKSQEE-----KEQEKEKRVTTLKEE 231
K +E + +L + E ++ + + +++S EE ++Q KE T+ +
Sbjct: 1657 KLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRD 1716
Query: 232 LTK---LKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETH--------------TKL 274
L K LK + + + Q+ + + +K E++ K+ +L
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL 1776
Query: 275 ALAEARVQEEEQKATRLEKELQTQTTKF---HQDQDTIMAKLTNEDSQNRQLQQKLAALS 331
+A ++E+++ +L + +T K +D + AKL + + + + +L L
Sbjct: 1777 RIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836
Query: 332 RQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK 391
+ ++E ++ + + +++++D +SK E N + ++L + + +M+ +E
Sbjct: 1837 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL---AQKLHENLEEMKSVMKE--- 1890
Query: 392 MEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKE 451
RD +R+E ETL KLE ++L+++ ++K ++ L+
Sbjct: 1891 -----RDNLRRVE-ETL-----KLE----------RDQLKESLQETKARDLEIQQELKTA 1929
Query: 452 RMTTKQLSQELESLKVRIKE----LEAIESRLEKTEFTLKEDLTKL--KTLTVMFVDERK 505
RM +K+ + ++ L+ +I E + I+ L+K++ L++ + +L K L ++ V E
Sbjct: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Query: 506 TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERD 565
MS K ++++ Q + + + +V + TK+ +S E++ V KERD
Sbjct: 1990 NMSH---KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESL----EEIRIVAKERD 2042
Query: 566 DLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI 625
+L+ ++ + + + ++ + + R + ++ + K L+ T +L ++ ++I
Sbjct: 2043 ELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE--KRLLSDGQQHLTESLREKCSRI 2100
Query: 626 KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELA 685
KEL + + +D YE L R + + +F + VK L+
Sbjct: 2101 KELLKRYSEM-----------------DDHYECLNRLSLDLEKEIEFQKELSMRVKANLS 2143
Query: 686 ----KYKLAEKTETSHEQ--WLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL---- 735
+ K EK T++++ F R+ + K ++ V +KE+ HE + ++
Sbjct: 2144 LPYLQTKHIEKLFTANQRCSMEFHRIMK---KLKYVLSYVTKIKEEQHESINKFEMDFID 2200
Query: 736 -----------ICHLQGDHSVLQKKLNQQE-NRNRDLGREIENLTKELERYRHFSKSLRP 783
I HLQ D V ++L + N+N DL IE + K+ FS+S P
Sbjct: 2201 EVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDL--HIEEILKD------FSESEFP 2252
Query: 784 SL 785
S+
Sbjct: 2253 SI 2254
Score = 80.1 bits (196), Expect = 1e-14
Identities = 142/735 (19%), Positives = 313/735 (42%), Gaps = 131/735 (17%)
Query: 145 KVVEKHKESYRRILGQLLVAEKSRRQTI-------LELEEE-------KRKHKEYMEKSD 190
K V K +++ RR+ L + ++++ LE+++E ++HKE ++K
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLR 1944
Query: 191 EFICLLEQECERLKKLIDQ---EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQ 247
E I + ++K +D+ E++ + ++ Q+KE ++ +KE++ + + ++E +
Sbjct: 1945 EKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV----NMSHKKINEME 2000
Query: 248 RLTAQLTLQRQKIQELTTNAKETHTKL--ALAEARVQEEEQKATRLEKELQTQTTKFHQD 305
+L Q Q +Q + + + KL +L E R+ +E+ R KE + K +D
Sbjct: 2001 QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE----SLKMERD 2056
Query: 306 QD-TIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYG 364
Q + ++ D QN Q++ + LS D + SLR+ ++++ ++ S+ +
Sbjct: 2057 QFIATLREMIARDRQNHQVKPEKRLLS---DGQQHLTESLREKCSRIKELLKRYSEMD-- 2111
Query: 365 NAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK---------- 414
E L + LD+E +E+ +E + L LQ+K +
Sbjct: 2112 -----DHYECLNRLSLDLE---KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCS 2163
Query: 415 LEVEKLSKRIMAL--------EKLEDAFNKSKQECYSLKCNLEKER---MTTKQLSQELE 463
+E ++ K++ + E+ ++ NK + + +EK++ + + L Q+ +
Sbjct: 2164 MEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFID---EVEKQKELLIKIQHLQQDCD 2220
Query: 464 SLKVRIKELEAIESRLEKTEFTLKE----DLTKLKTLTVMFVDERKTMSEKLKK---TED 516
+++L+ ++ E LK+ + +KT + RK M++ L++ T
Sbjct: 2221 VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRF 2280
Query: 517 KLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE 576
++ + +Q E +++ V + T+ EE+ +++KE + LK+ +E
Sbjct: 2281 DIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE---WEQDLKSLKE 2337
Query: 577 KGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST-------------------TA 617
K L LK L S + NK + ++T +A
Sbjct: 2338 KNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESA 2397
Query: 618 LHQENNKIKELSQEVE-------RLKLKLKDMKAIEDDLMKTEDEYETLERRYA--NERD 668
+H+E +KI ++ +E+E +L+ K+ + L KT++ + L+ + A +
Sbjct: 2398 MHKE-SKIIKMQKELEVTNDIIAKLQAKVHESNKC---LEKTKETIQVLQDKVALGAKPY 2453
Query: 669 KAQFLSKELEHVKMELAKYKLAEKTE--------TSHEQWLFKRLQEEEAKSGHLSREVD 720
K + +++ VK++L K K A++ E T Q RL E + +++
Sbjct: 2454 KEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTS 2513
Query: 721 ALKEKIHEYMATEDLICH-------------LQGDHSVLQKKLNQQENRNRDLGREIENL 767
+ E + + L C L+ +H L+K++++ + +N L I+
Sbjct: 2514 VISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQL---IKQK 2570
Query: 768 TKELERYRHFSKSLR 782
+ L +H S ++
Sbjct: 2571 NELLSNNQHLSNEVK 2585
Score = 34.3 bits (77), Expect = 0.69
Identities = 49/245 (20%), Positives = 101/245 (41%), Gaps = 30/245 (12%)
Query: 79 LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEK 138
++ EL+ +++I L+A+ + E+ K+ ++ LQ D + P++E+I +
Sbjct: 2407 MQKELEVTNDIIAKLQAK-----VHESNKCLEKTKETIQVLQ-DKVALGAKPYKEEIEDL 2460
Query: 139 PMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ 198
M + +EK K + E E+E K +E E I LL +
Sbjct: 2461 KMKLVKIDLEKMKNAK-------------------EFEKEISATKATVEYQKEVIRLLRE 2501
Query: 199 ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQ 258
R ++ D + S+ Q K +T + AL++ E RL +++ +Q
Sbjct: 2502 NLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQ 2561
Query: 259 KIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDS 318
+ ++L E + V+ +++ L++E Q T + + K+T S
Sbjct: 2562 QNEQLIKQKNELLSNNQHLSNEVKTWKERT--LKREAHKQVTCENSPKS---PKVTGTAS 2616
Query: 319 QNRQL 323
+ +Q+
Sbjct: 2617 KKKQI 2621
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 127 bits (320), Expect = 5e-29
Identities = 193/832 (23%), Positives = 357/832 (42%), Gaps = 131/832 (15%)
Query: 34 RQQDKDSPSESDVILPCP----------KAEKPHSGNGHQAEDLSRDDLLFLLSILEGEL 83
+Q+ ++ P DV+ P P K E P S ED + + LE
Sbjct: 232 KQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTS------VKTLETLQ 285
Query: 84 QARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNEL 143
Q +LK K + + Q +T +K EALQ ++ + EL
Sbjct: 286 QRVKRQENLLKRCKETIQSHKEQCTLLTSEK--EALQEQL-------------DERLQEL 330
Query: 144 DKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH-KEYMEKSDEFICLLEQECER 202
+K+ + H +++ QL + + I +LE++K E + E + + E+E +
Sbjct: 331 EKIKDLHMAEKTKLITQL----RDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ 386
Query: 203 LKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFA--------------------LMV 242
L+ I Q EE ++KEK EEL K S A +
Sbjct: 387 LRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK 446
Query: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLA-LAEARVQEEEQKATRLEKELQTQTTK 301
E++R++ Q L R K + + K + ++A L + +E +K L K+LQT+ +
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRERE 506
Query: 302 FHQDQDTIMAKLTNE---DSQNRQLQQKLAALSRQIDELEETNRS-LRKAEEELQDIKEK 357
F + + K +E SQ ++ Q+ LA ++ELE ++ L ++E +L+D+++
Sbjct: 507 FQEQMKVALEKSQSEYLKISQEKEQQESLA-----LEELELQKKAILTESENKLRDLQQ- 560
Query: 358 ISKGEYGNAGIMAEVEELRKRVLDMEGK-DEELIKMEEQCRDLNKRLERE-TLQSKDFKL 415
E E R R+L++E ++ L + + Q +DL LE E +K+ +
Sbjct: 561 -------------EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607
Query: 416 EVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKEL--- 472
VEK + +L+ +DA K + + E E++ K QE E+L ++ KE+
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK-CEQEKETL-LKDKEIIFQ 665
Query: 473 EAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKV 532
IE EKT L T+L++L+ +SE L K KL+ S L+ + +K+
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLS-------SELSEVL-KARHKLEEELSVLKDQTDKM 717
Query: 533 TTVTEKLIEETKRALKSKTD--VEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKN 590
E ++E K + + D ++E S+ + LK+++ E L R LK
Sbjct: 718 KQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELL---LKERDKHLKE 774
Query: 591 RLQSLEAIEKDFLKN--KLNQDSGK------STTALHQENNKIKELSQEVERLKLKLKDM 642
+E +E D ++ +L Q S K +A H++ K +++ +L+ KL D+
Sbjct: 775 HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT---KAYEEQLAQLQQKLLDL 831
Query: 643 KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLF 702
+ L K E E ++ E D + ++L + EK + EQ +
Sbjct: 832 ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDL---------MQQLEKQNSEMEQKVK 882
Query: 703 KRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNR 758
Q E+K ++E + K+ + E E++I + + + +L +KL+ +E+
Sbjct: 883 SLTQVYESKLEDGNKEQEQTKQILVE---KENMILQMREGQKKEIEILTQKLSAKEDSIH 939
Query: 759 DLGREIE----NLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVD 806
L E E N K++E+ + +K ++ +L + + KE++ A++
Sbjct: 940 ILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991
Score = 107 bits (266), Expect = 8e-23
Identities = 149/698 (21%), Positives = 303/698 (43%), Gaps = 111/698 (15%)
Query: 167 SRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERL---KKLIDQEIKSQEEKEQEKEK 223
+ Q L + ++ H+ +E+ + I ++ + E L K+ + +E +Q++ EKE
Sbjct: 1282 TEEQNTLNISFQQATHQ--LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
Query: 224 RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKET----HTKLALAEA 279
+T LK+EL++ + ++ +E + +++ +++ +L + + + A++
Sbjct: 1340 CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSL 1399
Query: 280 RVQEEEQKATRLEK--------------------ELQTQTTKFHQDQDTIMAKLTNEDSQ 319
R Q +E+K L++ ++ + KF + + ++ T +
Sbjct: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459
Query: 320 NRQLQQKLAALSRQI-----------DELEETNRSLRKAEEELQDIKEKISKGEYGNAGI 368
++LQ +L S++ +EL++ N+ + E++D K K+ K E + +
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKE---SNL 1516
Query: 369 MAEVEELRKRVLDMEG----KDEELIKMEEQCRDLN--KRLERETLQSK--DFKLEVEKL 420
E++ R++++E K E+ + E ++ N K +E + L K F+ E+
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEK 1576
Query: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE 480
R+ ++ E+ + + YS+K LE ++ K+L S+K + +EL+A+E RLE
Sbjct: 1577 DNRV---KEAEEKILTLENQVYSMKAELETKK---KELEHVNLSVKSKEEELKALEDRLE 1630
Query: 481 KTEFTLKEDLT-----KLKTLTVMFVDERKTMSEKLKK-TEDKLQAASSQLQVEQNKVTT 534
+L K+ + + + + E+ KK TE L +++LQ + +V
Sbjct: 1631 SESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHI 1690
Query: 535 VTEKL----IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK----------GND 580
+ EKL +++ + ++ Y+ +E D K EEK
Sbjct: 1691 LEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
Query: 581 LLSRVNMLKN---------RLQSLEAIEK-DFLKNKLNQDS---GKSTTALHQENNKIKE 627
LL RV K R Q E + K + + K ++D G L ++N K
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
Query: 628 L-SQEVERLKLK-----LKDMKAIEDDLMKTEDEYET----LERRYANERDKAQFLSKEL 677
+ +Q VE+ K ++++ + DD+ KT E E LE++ E D KE+
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI-KELDSCLVRQKEV 1869
Query: 678 EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
V+ME +L K E + LQ+ + ++ + +EK ++ L+
Sbjct: 1870 HRVEME----ELTSKYEK------LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
Query: 738 HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 775
+++ H+ L+ KL E + LG+EI L K+L R
Sbjct: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
Score = 95.9 bits (237), Expect = 2e-19
Identities = 153/712 (21%), Positives = 306/712 (42%), Gaps = 89/712 (12%)
Query: 114 KVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTIL 173
K EA ++D Q + D K + L +E K + L KS+ I+
Sbjct: 1470 KSKEAYEKDE-QINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528
Query: 174 ELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELT 233
ELE+ + +E +E + Q+ + K + Q+++ +E +EK+ RV +E++
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 234 KLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEE--------- 284
L+ ++ + A+L ++++++ + + K +L E R++ E
Sbjct: 1589 TLE-------NQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELK 1641
Query: 285 ---EQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETN 341
EQK ++K+L +Q ++++ K T +S +L KL R++ LEE
Sbjct: 1642 RKAEQKIAAIKKQLLSQM----EEKEEQYKKGT--ESHLSELNTKLQEREREVHILEEKL 1695
Query: 342 RSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNK 401
+S+ ++ E + N E EE + + +E++ ++ + K
Sbjct: 1696 KSVESSQSETLIVPRSAK-----NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK 1750
Query: 402 RL-----ERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNL-EKERMTT 455
L E+E S F++ + +R++ LE E ++ + L+ L EK + +
Sbjct: 1751 LLQRVGQEKEETVSSHFEMRCQ-YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYS 1809
Query: 456 KQLSQ--ELESLKVRIKELEAIESRLEKTEFTLKE-DLT------KLKTLTVMFVDERKT 506
++Q E E K I+ + +E+ + + TL+E +LT K+K L V +++
Sbjct: 1810 LIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEV 1869
Query: 507 MSEKLKKTEDKLQAASSQLQVE-QNKVTTVTEKLIEETKRALKSKTD-VEEKMYS-VTKE 563
++++ K + + Q++ +NK T + E+ EE KSK+ V+ K+ S + +
Sbjct: 1870 HRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE-----KSKSHLVQPKLLSNMEAQ 1924
Query: 564 RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL---EAIEKDFLKNKLNQDSGKSTTALHQ 620
+DL+ KL E + L + L+ L+ L E + LK + +Q+
Sbjct: 1925 HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQE---------- 1974
Query: 621 ENNKIKELSQEVERLKLK----LKD-MKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 675
+ +++ QE E L+LK LK M+ L + E E E + N+ + +
Sbjct: 1975 ---REEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELL 2031
Query: 676 ELEHVKMELAKYKLAEK------TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEY 729
E + K+AEK T +E+ L R +E AK L +++ L++K +
Sbjct: 2032 ESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK 2091
Query: 730 MATED-------LICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERY 774
+ E+ I LQ + ++ + + ++ +I NL L++Y
Sbjct: 2092 LEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKY 2143
Score = 90.1 bits (222), Expect = 1e-17
Identities = 138/707 (19%), Positives = 293/707 (41%), Gaps = 88/707 (12%)
Query: 31 MKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVI 90
++ ++Q+ + ++ C K E + E + +D L + L+ +L+ + +
Sbjct: 1066 LQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTL---NELQEQLKQKSAHV 1122
Query: 91 GILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKH 150
L ++ L K LE L+ D ++ + ++ + EL + E+
Sbjct: 1123 NSLAQDETKL------------KAHLEKLEVDLNKSLK---ENTFLQEQLVELKMLAEED 1167
Query: 151 KESYRRILGQLLVAEKSRRQTILELEEEKR----KHKEYMEKSDEFICLLEQECERLKKL 206
K + +L ++ + E+ + K E+ + S+E L+ C++ + L
Sbjct: 1168 KRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227
Query: 207 IDQE----IKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQE 262
++ + I K R++ + TK+K L+ L AQL ++
Sbjct: 1228 LEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNT 1287
Query: 263 LTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQ 322
L + ++ +L E +++ + L E + + Q K + ++
Sbjct: 1288 LNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKE 1347
Query: 323 LQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDM 382
L + + A++ +EL+E + ++L D+ ++ + + A + LRK+
Sbjct: 1348 LSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL-QNSISLSEKEAAISSLRKQY--- 1403
Query: 383 EGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK-RIMALEKLEDAFNKSKQEC 441
DEE ++ +Q +DL+ +V+ LSK +I ALE+++D NK +
Sbjct: 1404 ---DEEKCELLDQVQDLS--------------FKVDTLSKEKISALEQVDDWSNKFSEWK 1446
Query: 442 YSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFV 501
+ + + T K+L +LE ++ KE + ++ + L + + L
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLE---LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 502 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVT--TVTEKLIEETKRALKSKTDVEEKMYS 559
D++ M +K E +L++ ++++ ++ +T T+ + + E + + D+E K
Sbjct: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHK--- 1560
Query: 560 VTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALH 619
+L KL+ +E G + +RV + ++ +LE N++ + T
Sbjct: 1561 ------ELVQKLQHFQELGEEKDNRVKEAEEKILTLE--------NQVYSMKAELET--- 1603
Query: 620 QENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEH 679
K KEL +K K +++KA+ED L ++E + E + E+ A + L
Sbjct: 1604 ----KKKELEHVNLSVKSKEEELKALEDRL-ESESAAKLAELKRKAEQKIAAIKKQLLSQ 1658
Query: 680 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI 726
++ + +YK K SH L +LQE E REV L+EK+
Sbjct: 1659 MEEKEEQYK---KGTESHLSELNTKLQERE-------REVHILEEKL 1695
Score = 51.6 bits (122), Expect = 4e-06
Identities = 82/380 (21%), Positives = 167/380 (43%), Gaps = 48/380 (12%)
Query: 19 HTKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSI 78
H + + + H Q++ + ++ ++ EK N QA + +L +
Sbjct: 1782 HAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA----KQNLENVFDD 1837
Query: 79 LEGELQARDEVIGIL--KAEKMDLALLE------AQYGFVTPK-KVLEALQRDAFQAKST 129
++ LQ ++ IL K +++D L+ + +T K + L+ALQ+ + K T
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT 1897
Query: 130 PW-QEDIYEKPMNEL--DKVVEKHKESYRRILGQLLVAEKSRRQT---ILELEEE----K 179
+E+ EK + L K++ + + + +L AE+ +++ I+ L+++ +
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
Query: 180 RKH--------KEYMEKSDEFICLLEQECE-----RLKKLIDQEIKSQEEKEQEKEKRVT 226
++H KEY ++ +E I +++ E LK+L+ + +KEQE E
Sbjct: 1958 KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM--- 2014
Query: 227 TLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQ 286
T+KE + K + +++ Q T QL +KI E + K T + E + E+
Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLL---KKIAEKDDDLKRTAKRY---EEILDAREE 2068
Query: 287 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQN---RQLQQKLAALSRQIDELEETNRS 343
+ T ++LQTQ + + + + N + N +LQ +LA + I + + +
Sbjct: 2069 EMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
Query: 344 LRKAEEELQDIKEKISKGEY 363
R+ L+D +K K Y
Sbjct: 2129 FREQIHNLEDRLKKYEKNVY 2148
Score = 42.7 bits (99), Expect = 0.002
Identities = 99/445 (22%), Positives = 184/445 (41%), Gaps = 109/445 (24%)
Query: 478 RLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTE 537
R+E++ + + ++L T M E+K + L +++DK ++L+ E +
Sbjct: 145 RMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKK 204
Query: 538 KLIEETKRALKSK---TDVEEKMYSVTKER--------DDLK---------NKLKAEEEK 577
L EE +L+ K V + S+ K+R D LK EE
Sbjct: 205 HLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENP 264
Query: 578 GND----------------LLSRVNMLKNRLQ-------------SLEAIEKDFLKNKLN 608
+D L RV +N L+ +L EK+ L+ +L+
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLD 324
Query: 609 Q--------------DSGKSTTALHQENNKIKELSQEV------------ERLKLKLKDM 642
+ + K T L N I++L Q+ E L++K +++
Sbjct: 325 ERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEI 384
Query: 643 KAIEDDL--MKTEDEYETLERRYANERDKAQFLSKELEHV-KMELAKYKLAEKTETSHEQ 699
+ + M T+ E E E++ +ER + L K L K E A+ KL K E +
Sbjct: 385 AQLRSRIKQMTTQGE-ELREQKEKSERAAFEELEKALSTAQKTEEARRKL--KAEMDEQI 441
Query: 700 WLFKRLQEEEAKSGHLSREVDALKEKIHEYM--ATEDLICHLQGDHSVLQKKLNQQENRN 757
++ EEE S L +E+ +K+++ + M ++E+ I LQ KL+++E
Sbjct: 442 KTIEKTSEEERIS--LQQELSRVKQEVVDVMKKSSEEQIAKLQ--------KLHEKE--- 488
Query: 758 RDLGREIENLTKELE-RYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLI 816
L R+ + LTK+L+ R R F + ++ +L + ++ ++ Q E++ E + +
Sbjct: 489 --LARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ--- 543
Query: 817 PLERAVINGQLYEESENQDEDPNDE 841
++A++ ESEN+ D E
Sbjct: 544 --KKAILT-----ESENKLRDLQQE 561
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 124 bits (312), Expect = 4e-28
Identities = 164/667 (24%), Positives = 293/667 (43%), Gaps = 106/667 (15%)
Query: 32 KHRQQDKDSPSESDVILPCPKAEKPHSG--NGHQAEDLSRDDLLFLLSILEGELQARDE- 88
K R Q+K + E + P+ E + HQ +D R+ LS L+ +L+ ++
Sbjct: 1045 KSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKE 1104
Query: 89 ---------VIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKP 139
V +LK EK A E + +T + EA + A Q + T I+
Sbjct: 1105 RAMAEGKITVKEVLKVEKD--AATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALE 1162
Query: 140 MNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQE 199
VV+ E R I+ AE LEL E++RK++ E+ + LE
Sbjct: 1163 EENAKVVVQ---EKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEAL 1219
Query: 200 CER-----LKKLIDQEIKSQEEKEQEKEKR-------------------VTTLKEELTKL 235
R +K++ + IK + + E EKE + + LK+E+ L
Sbjct: 1220 RRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQAL 1279
Query: 236 KSFALMVV------------------DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALA 277
K V +E L A+L+ +++K +L ++A
Sbjct: 1280 KDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARK 1339
Query: 278 E---ARVQEE--EQKATRLEKE--LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAAL 330
E +RV+E +Q+ R E+E L+ + + F + D + ++ ++ R+LQ++ L
Sbjct: 1340 EEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTEL 1399
Query: 331 SRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLD---MEGKDE 387
RQ++ELE ++ R+AE E+Q ++++++ E A +V +K VL + ++
Sbjct: 1400 ERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREH 1459
Query: 388 ELIKM---EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 444
L+++ EEQ R E ETL+ K LE ++ ++++ E ++ ++QE L
Sbjct: 1460 ALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRL 1519
Query: 445 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
K +LE+E + ++L E+ L+ R+ ELE S+ K L+E+
Sbjct: 1520 KSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREE--------------- 1564
Query: 505 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
+ KL+ LQ + +LQ E N T T L T S T+ + +++S+ +E
Sbjct: 1565 ---NHKLQLERQNLQLETRRLQSEINMAATETRDLRNMT--VADSGTNHDSRLWSLEREL 1619
Query: 565 DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK 624
DDLK K DL ++ L+ RL S+ A++++ +N L +S +H +
Sbjct: 1620 DDLKRL-----SKDKDL--EIDELQKRLGSV-AVKREQRENHLR----RSIVVIHPDTG- 1666
Query: 625 IKELSQE 631
+ELS E
Sbjct: 1667 -RELSPE 1672
Score = 102 bits (254), Expect = 2e-21
Identities = 161/734 (21%), Positives = 320/734 (43%), Gaps = 98/734 (13%)
Query: 79 LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEA----LQRDAF--QAKSTPWQ 132
LE E+++ E I L+ + +++ + P VLE LQR Q K+ Q
Sbjct: 909 LENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQ 968
Query: 133 EDI--YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQT--ILELEEEKRKHKEYMEK 188
E++ + + L++ + Y ++ ++L E R Q +L+L EE +
Sbjct: 969 EELEALQLQLRALEQETRDGGQEY--VVKEVLRIEPDRAQADEVLQLREELEALRRQKGA 1026
Query: 189 SDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQR 248
+ + LL+Q R+ L +++ ++QE+ EK V L+ + +L++ + ++ QR
Sbjct: 1027 REAEVLLLQQ---RVAALAEEKSRAQEKVT---EKEVVKLQND-PQLEAEYQQLQEDHQR 1079
Query: 249 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 308
Q +++ L K + A+AE ++ +E ++EK+ T+ ++
Sbjct: 1080 QDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKE--VLKVEKDAATE-----REVSD 1132
Query: 309 IMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGI 368
+ + +E ++ R Q++ L R+I LEE N + +E++++I K E
Sbjct: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKV-VVQEKVREIVRPDPKAE------ 1185
Query: 369 MAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 428
+EV LR +++ E K EEQ R LE L+ + ++EV++++K ++ +
Sbjct: 1186 -SEVANLRLELVEQERKYRGA---EEQLRSYQSELE--ALRRRGPQVEVKEVTKEVIKYK 1239
Query: 429 ---KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEF- 484
++E + ++E +E+ + QL +E+++LK +++ E E +F
Sbjct: 1240 TDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQ 1299
Query: 485 ----------TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTT 534
+L+ L++ + V ER + E++ + E++L ++ V+Q V
Sbjct: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERV-VQQEVVRY 1358
Query: 535 VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 594
E + A DVE ++ D L+ +L+ + + +L ++ L+ Q+
Sbjct: 1359 EEEPGLRAEASAFAESIDVE------LRQIDKLRAELRRLQRRRTELERQLEELERERQA 1412
Query: 595 LEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT-- 652
E++ Q + AL QE + +E +++ L+ +A E L++
Sbjct: 1413 RREAEREV------QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQL 1466
Query: 653 ----------EDEYETLERRYANERDKAQFLSKEL--EHVKMELA---------KYKLAE 691
E E ETL R+ A +KA+ K + E V++E K L E
Sbjct: 1467 EEEQHRRQLLEGELETLRRKLA-ALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEE 1525
Query: 692 KTETSHE-----QWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVL 746
++ + E L RL E E + S+E+D L+E+ H+ +LQ + L
Sbjct: 1526 ESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQ---NLQLETRRL 1582
Query: 747 QKKLNQQENRNRDL 760
Q ++N RDL
Sbjct: 1583 QSEINMAATETRDL 1596
Score = 85.5 bits (210), Expect = 3e-16
Identities = 147/689 (21%), Positives = 302/689 (43%), Gaps = 111/689 (16%)
Query: 164 AEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ-------ECERLKKLIDQEIKSQEE 216
A K R++ E E ++ E +E L Q E LKK+ D ++ +
Sbjct: 892 AWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQ 951
Query: 217 KEQ----EKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHT 272
+ Q E++ + L+EEL L+ L ++++ R Q + ++ ++ + + +
Sbjct: 952 QLQRTLAEEQHKNQLLQEELEALQ-LQLRALEQETRDGGQEYVVKEVLR-IEPDRAQADE 1009
Query: 273 KLALAEARVQEEEQKATRLEKE---LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAA 329
L L E QK R E E LQ + +++ K+T ++ Q +L A
Sbjct: 1010 VLQLREELEALRRQKGAR-EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEA 1068
Query: 330 LSRQIDELEETNRSLR-KAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEE 388
+Q+ E + LR K EEEL +++K+ + E A MAE + K VL +E KD
Sbjct: 1069 EYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERA--MAEGKITVKEVLKVE-KDAA 1125
Query: 389 LIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE----------KLEDAFN--- 435
E + DL ++ E E +++ + E +L ++I ALE K+ +
Sbjct: 1126 T---EREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDP 1182
Query: 436 KSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKT 495
K++ E +L+ L ++ + ++L S + ELEA+ R + E +++TK
Sbjct: 1183 KAESEVANLRLELVEQERKYRGAEEQLRSYQ---SELEALRRRGPQVEV---KEVTK--- 1233
Query: 496 LTVMFVDERKTMSEKLK-KTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 554
E +K KT+ +++ +L+ E+++++T+ L + D+E
Sbjct: 1234 -------------EVIKYKTDPEMEKELQRLR----------EEIVDKTR--LIERCDLE 1268
Query: 555 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKS 614
+Y + KE LK+ + K +++ + + Q+ E + L+ KL+++ K
Sbjct: 1269 --IYQLKKEIQALKDTKPQVQTK--EVVQEILQFQEDPQTKEEVAS--LRAKLSEEQKKQ 1322
Query: 615 TTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLS 674
+ ++ ++++++ E L ++K+ + ++ ++++ E+E A A+ +
Sbjct: 1323 VDLERERASQEEQIARKEEELS-RVKE-RVVQQEVVRYEEE----PGLRAEASAFAESID 1376
Query: 675 KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI----HEYM 730
EL + A+ + ++ T E+ L + L+ E REV L++++ E
Sbjct: 1377 VELRQIDKLRAELRRLQRRRTELERQL-EELERERQARREAEREVQRLQQRLAALEQEEA 1435
Query: 731 ATEDLICHLQG-----------DHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSK 779
+ + H Q +H++L+ +L ++++R + L E+E L ++L
Sbjct: 1436 EAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-------- 1487
Query: 780 SLRPSLNGRRISDPQVFSKEVQTEAVDNE 808
+L + + V S+ VQ E D E
Sbjct: 1488 ---AALEKAEVKEKVVLSESVQVEKGDTE 1513
Score = 81.6 bits (200), Expect = 4e-15
Identities = 159/744 (21%), Positives = 317/744 (42%), Gaps = 114/744 (15%)
Query: 165 EKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQE--IKSQEEKEQEKE 222
+K+ I E+E +K ++ + + E E E+L+ L+D E S K +
Sbjct: 770 QKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
Query: 223 KRVTTLKEELTKL--KSFALMVVDEQ--QRLTAQLTLQRQKIQELTTNAKETHTKLALAE 278
T +KEE L K + ++ Q Q L L L RQ+ + T+ L
Sbjct: 830 SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHE-------TLQR 882
Query: 279 ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE 338
R ++A ++ KEL +T + Q ++ + K T E+ + Q ++ R+ + L+
Sbjct: 883 NRPDSGVEEAWKIRKELDEETERRRQLENEV--KSTQEEIWTLRNQGPQESVVRK-EVLK 939
Query: 339 ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVE--ELRKRVLDMEGKD-------EEL 389
+ + EE Q ++ +++ ++ N + E+E +L+ R L+ E +D +E+
Sbjct: 940 KVPDPV--LEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEV 997
Query: 390 IKME------EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL--EKLEDAFNKSKQEC 441
+++E ++ L + LE Q + EV L +R+ AL EK +++E
Sbjct: 998 LRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEV 1057
Query: 442 YSLKCN---------LEKERMTTKQL----SQELESLKVRIKELEAIESRLEKTEFTLKE 488
L+ + L+++ QL +EL L+ ++K LE E + + + T+KE
Sbjct: 1058 VKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEK-ERAMAEGKITVKE 1116
Query: 489 DL---------TKLKTLTVMFVDE-RKTMSEKLKKTE--DKLQAASSQLQVEQNKVTTVT 536
L ++ LT + DE K + + +KTE K+ A E+N V
Sbjct: 1117 VLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALE-----EENAKVVVQ 1171
Query: 537 EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 596
EK+ E + K++++V + ++ + K + EE+ S + L+ R +E
Sbjct: 1172 EKVREIVRPDPKAESEVANLRLELVEQ----ERKYRGAEEQLRSYQSELEALRRRGPQVE 1227
Query: 597 A--IEKDFLKNKLNQDSGKSTTALHQE-----------NNKIKELSQEVERL---KLKLK 640
+ K+ +K K + + K L +E + +I +L +E++ L K +++
Sbjct: 1228 VKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQ 1287
Query: 641 DMKAIEDDLM-----KTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTET 695
+ +++ L +T++E +L + + E+ K L +E + ++A+ + E+
Sbjct: 1288 TKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKE--EELSR 1345
Query: 696 SHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQEN 755
E+ + + + E + G L E A E I + D L+ +L + +
Sbjct: 1346 VKERVVQQEVVRYEEEPG-LRAEASAFAESIDVELRQID----------KLRAELRRLQR 1394
Query: 756 RNRDLGREIENLTKELERYRHFSKS---LRPSLNGRRISDPQVFSKEVQTEAV--DNEPP 810
R +L R++E L +E + R + L+ L + + K T+ V +P
Sbjct: 1395 RRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQ 1454
Query: 811 DYKSLIPLERAVINGQLYEESENQ 834
+ E A++ QL EE +
Sbjct: 1455 QAR-----EHALLRLQLEEEQHRR 1473
Score = 75.5 bits (184), Expect = 3e-13
Identities = 139/681 (20%), Positives = 279/681 (40%), Gaps = 98/681 (14%)
Query: 219 QEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQ-------------LTLQRQKIQELTT 265
Q+ +R LK +L L + E+ R TA+ L R ++++ T
Sbjct: 540 QDSAERAKDLKNITNEL----LRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVED--T 593
Query: 266 NAKETHTKLALAEARVQEEEQKATRLEKELQTQ-----TTKFHQDQDTIMAKLTNEDSQN 320
N K H L A QE+ A RLEK LQ T + H +QD + + +
Sbjct: 594 NRKYEHLLQLLDLA--QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPE------SS 645
Query: 321 RQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVL 380
R L K L+ EL+ L + E+ LQ K+ S ++
Sbjct: 646 RVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSS----------TLASRFQEHCP 695
Query: 381 DMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK-RIMALEKLEDAFNKSKQ 439
D+E ++ E+ K+ ++ +L +++ER + K E + L+ L + Q
Sbjct: 696 DLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
Query: 440 ECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVM 499
E SL +E + K L E+ S + ++++ A + ++
Sbjct: 756 ETDSLS-QMETKLKNQKNLLDEIASREQEVQKICANSQQYQQA----------------- 797
Query: 500 FVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYS 559
V + + +EKL+ D SS + + T+ ++E + AL +K ++Y+
Sbjct: 798 -VKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATK--VKEEEAALAAKFT---EVYA 851
Query: 560 VTKER-DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTAL 618
+ ++R +L+ L ++ ++ + +NR S +E+ + K+ ++ + T
Sbjct: 852 INRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDS--GVEEAW---KIRKELDEETERR 906
Query: 619 HQENNKIKELSQEVERLKLKLKDMKAIEDDLMKT------EDEYETLERRYANERDKAQF 672
Q N++K +E+ L+ + + +++K E+ ++ L+R A E+ K Q
Sbjct: 907 RQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQL 966
Query: 673 LSKELEHVKMELAKYKLAEKTETSHEQWLFK---RLQEEEAKSG---HLSREVDALKE-- 724
L +ELE ++++L L ++T ++++ K R++ + A++ L E++AL+
Sbjct: 967 LQEELEALQLQLR--ALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQK 1024
Query: 725 --KIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 782
+ E + + + L + S Q+K+ ++E ++E ++L+ LR
Sbjct: 1025 GAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLR 1084
Query: 783 PSLNGRRISDPQVFSKEVQTE-AVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDE 841
+S Q K ++ E A+ K ++ +E+ E E D E
Sbjct: 1085 EK-QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT-----EREVSDLTRQYE 1138
Query: 842 GSVLSFKCSQSTPCPVNRKLW 862
+ SQ + RK+W
Sbjct: 1139 DEAAKARASQREKTELLRKIW 1159
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 124 bits (311), Expect = 5e-28
Identities = 157/762 (20%), Positives = 329/762 (43%), Gaps = 79/762 (10%)
Query: 79 LEGELQARDEVIGILKAEKMDL-ALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYE 137
LE LQ E I +L+ E+ DL A ++A G E + Q K+ QE + +
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEG--------ETAVLNQLQEKNHTLQEQVTQ 579
Query: 138 KPMNELDKVVEKHKESYRRILGQLLVAE---KSRRQTILELEEEKRKHKEYMEKSDEFIC 194
+L E HK++ + Q+ + ++ + +L LE + + +S E +
Sbjct: 580 LT-EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVS 638
Query: 195 LLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLT 254
L+ + + +L+ ++ + + + + T + L + + + ++TA+L
Sbjct: 639 QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ 698
Query: 255 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKE-LQTQTTKFHQDQDTIMAKL 313
+++ +L ++ KE K E + +E E + +LE + L+ + +K QD +
Sbjct: 699 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758
Query: 314 TNED--------SQNRQLQQKLAA-----LSRQIDELEETNRSLRKAEEELQDIKE---- 356
N D S+ ++++++ + L ++ + LE + L K EEE Q +K+
Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 357 -----KISKGEYGNAGIMAEVEELRKRVLDMEGK-------DEELIKMEEQCRDLNKRLE 404
KI E N I V EL+K ++ E ++L K+ + ++ E
Sbjct: 819 LSQETKIQHEELNNR-IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877
Query: 405 RETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELES 464
+E + K L++EK K + +L+ + +E LK +LEKE+ + QL EL S
Sbjct: 878 KENQKGKAAILDLEKTCKELK--HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
Query: 465 LKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK-----------K 513
++ ++ + + + EK E L+ ++ +LK + + + + +LK K
Sbjct: 936 MQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENK 995
Query: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
+ +L A+ +L E+ K++ + + + + ++D + + R DLK+ +
Sbjct: 996 LQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055
Query: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL----- 628
DL+S N + N+ + ++ ++ K L QDS K L + ++++
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKT--AKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113
Query: 629 --SQEVERLKLKLKDMKAI----EDDLMKTEDEYETLE----RRYANERDKAQFLSKELE 678
+E+ K KL +++ I E ++ K +E ++ + + N +D Q L ++
Sbjct: 1114 LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1173
Query: 679 HVKMELAKYKLAEKTETSHEQWLFKRL--QEEEAKSGHLSREV---DALKEKIHEYMATE 733
++ + K A + E ++Q L ++ +EEE K + +E +KEK E
Sbjct: 1174 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 734 DLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 775
+ L + L + L + + R + L K+ + R
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Score = 117 bits (292), Expect = 8e-26
Identities = 125/644 (19%), Positives = 290/644 (45%), Gaps = 42/644 (6%)
Query: 160 QLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQ 219
+LL E+ + L+E+++ E + ++ + L+ + RL++ + +++ + E +
Sbjct: 422 KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQH 481
Query: 220 EKEKRVTTLKEELTKLKSFALMVVDEQ---QRLTAQLTLQRQKIQELTTNAKETHTKLAL 276
+ +K +E+ +S + + Q +++ Q+ + QKIQ L +++ ++L
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
Query: 277 AE-------ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAA 329
E A++Q E + T + +LQ + + + KL N+ ++Q Q+ L
Sbjct: 542 LEKEREDLYAKIQAGEGE-TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH- 599
Query: 330 LSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEEL 389
D+++E LR A++ + ++ +++ N+ + E++ + + ++ K E L
Sbjct: 600 -----DQVQEQKAHLRAAQDRVLSLETSVNEL---NSQLNESKEKVSQLDIQIKAKTELL 651
Query: 390 IKMEE----QCRDLNKRLERETLQSKDFKLEVEKLSKRI-MALEKLEDAFNKSKQECYSL 444
+ E Q DL L+ +D + E+ K++ ++ KL+D ++ C L
Sbjct: 652 LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD----KQEHCSQL 707
Query: 445 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
+ +L++ + L Q+ E L+ +IK+LEA ++ ++ +DL + + L
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 505 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKER 564
+S++L+ ++ + + LQ + + ++ +KL ++ + K D E +
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 565 DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK 624
++L N+++ + L +V M K L + + KD L +K++ S + +EN K
Sbjct: 828 EELNNRIQTTVTE----LQKVKMEKEALMTELSTVKDKL-SKVSDSLKNSKSEFEKENQK 882
Query: 625 IKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL 684
K ++E+ +LK ++ + T E + L++ E++ + L EL ++ +L
Sbjct: 883 GKAAILDLEKTCKELKHQLQVQ--MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQL 940
Query: 685 AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHS 744
+ + K EQ L + E + S ++++AL+ ++ + + + +
Sbjct: 941 IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL------EN 994
Query: 745 VLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGR 788
LQ++L Q +I L E+ + K L+ GR
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Score = 113 bits (283), Expect = 9e-25
Identities = 161/798 (20%), Positives = 350/798 (43%), Gaps = 76/798 (9%)
Query: 80 EGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKP 139
+G Q + G++ +L LE Q LE Q + F K +D++E+
Sbjct: 117 QGLQQQEAKPDGLVTDSSAELQSLEQQ---------LEEAQTENFNIKQ---MKDLFEQK 164
Query: 140 MNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR-----KHKEYMEKSDEFIC 194
+L + K Y AE+ + EL +E K + E +
Sbjct: 165 AAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVA 224
Query: 195 LLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLT 254
+L++E +++ L+D +E + ++ + L+ + ++ + E + ++
Sbjct: 225 VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 284
Query: 255 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 314
+ Q++Q+L ++ E K + ++EQ T+LE++ ++ + I A L
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESV----SKKNIQATLH 340
Query: 315 NEDSQNRQLQQKLAA----LSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
+D +QLQ +L+A L R EL E + +K +EEL +++ K + +
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400
Query: 371 EVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRL-ERETLQSKDFKLEVEKLSKRIM 425
+ EE + L ++ + +L++ E Q + + RL E+ L S+ + ++++ +
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460
Query: 426 ALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL-KVRIKELEAIESRLEKTEF 484
L +LE+ + L+ L+K TKQ QE ++L + +L ++ LE+
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDK----TKQQHQEQQALQQSTTAKLREAQNDLEQVLR 516
Query: 485 TLKEDLTKLKTLTVMFVDERKTMSEKLKKTED---KLQAAS------SQLQVE----QNK 531
+ + K++ L + ++ +S K+ ED K+QA +QLQ + Q +
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576
Query: 532 VTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNR 591
VT +TEKL +++ +++ ++ +++ ++++ + E N+L S++N K +
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636
Query: 592 LQSLEAIEKDFLKNKLNQDSGKSTTALHQEN------NKIKELSQEVERLKLKLKDMKAI 645
+ L+ K + L+ ++ K+ +N N +++ QE+ ++ +L + A
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA- 695
Query: 646 EDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRL 705
L ++ LE ++K L ++ E ++ ++ K + + ++ + L
Sbjct: 696 --KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753
Query: 706 QEE-------EAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNR 758
Q++ E ++ LS++++ KE + DL + S+ Q KL +QE +
Sbjct: 754 QQQRQLNTDLELRATELSKQLEMEKEIVSS--TRLDLQKKSEALESIKQ-KLTKQEEEKQ 810
Query: 759 DLGREIENLTKELERYRHFSKSLRPSLNGR-RISDPQVFSKEVQTEAVDNEPPDYK-SLI 816
L ++ E L++E +K LN R + + ++ +++ EA+ E K L
Sbjct: 811 ILKQDFETLSQE-------TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS 863
Query: 817 PLERAVINGQLYEESENQ 834
+ ++ N + E ENQ
Sbjct: 864 KVSDSLKNSKSEFEKENQ 881
Score = 102 bits (254), Expect = 2e-21
Identities = 156/724 (21%), Positives = 291/724 (40%), Gaps = 131/724 (18%)
Query: 169 RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
RQ + +L+ ++ K Y E+ L++E E+ + L QE K + VT
Sbjct: 89 RQEVQDLQASLKEEKWYSEE-------LKKELEKYQGLQQQEAKP--------DGLVTDS 133
Query: 229 KEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKA 288
EL L+ E + L QK +L T + +K + + EQK
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193
Query: 289 TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ--NRQLQQKLAALSRQIDELEETNRSLR- 345
TRL +EL + T + ++ + ED ++L Q + E E + L+
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD 253
Query: 346 ----------KAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKD----EELIK 391
+E + ++ +++KG A + E+++L+ V ++ K+ E L+K
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 313
Query: 392 MEEQCRDLNKRLERETLQSKDFK-------LEVEKLSKRIMA-----------LEKLEDA 433
E+ L ++ E++ K+ + L+ ++L R+ A L + +A
Sbjct: 314 KEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 373
Query: 434 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKVR----IKELEAIESRLEKTEFTLKED 489
K K+E ++ + + KQL Q+ E + E+ + S+L +TE L E
Sbjct: 374 TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEA 433
Query: 490 LTKLKTLTVMFVDERKTMSEKLKKTEDK---LQAASSQLQVE-QNKVTTVTE--KLIEET 543
+LK ++R+ SEKL E + LQ S+L+ + + KVT TE +++T
Sbjct: 434 HGRLK-------EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 544 KRALKSKTDVEEKMYSVTKE-RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK-- 600
K+ + + +++ + +E ++DL+ L+ +K + + +L+ +++ +EK
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER 546
Query: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD------------------- 641
+ L K+ G+ T L+Q K L ++V +L KLK+
Sbjct: 547 EDLYAKIQAGEGE-TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605
Query: 642 ---MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE---- 694
++A +D ++ E L + ++K L +++ K EL A KT
Sbjct: 606 KAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK-AKTELLLSAEAAKTAQRAD 664
Query: 695 -TSHEQWLFKRLQEEEA------------------KSGHLSREVDALKEKIHEYMATEDL 735
+H LQ+++ K H S+ LKE +Y++ E
Sbjct: 665 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724
Query: 736 ICHLQGDHSVLQ--------------KKLNQQENRNRDLGREIENLTKELERYRHFSKSL 781
L+G L+ + L QQ N DL L+K+LE + S
Sbjct: 725 TEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSST 784
Query: 782 RPSL 785
R L
Sbjct: 785 RLDL 788
Score = 99.4 bits (246), Expect = 2e-20
Identities = 141/665 (21%), Positives = 286/665 (43%), Gaps = 111/665 (16%)
Query: 116 LEALQRDAFQAKSTPWQ--EDIYEKPM---------NELDKVVEKHKE---SYRRILGQL 161
++ L+ D+ + K++ Q +D+ ++ EL K +E KE S R L +
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 162 LVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEK 221
A +S +Q + + EEEK+ +L+Q+ E L QE K Q E E
Sbjct: 792 SEALESIKQKLTKQEEEKQ--------------ILKQDFETLS----QETKIQHE---EL 830
Query: 222 EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL----A 277
R+ T EL K+K E++ L +L+ + K+ +++ + K + ++
Sbjct: 831 NNRIQTTVTELQKVKM-------EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG 883
Query: 278 EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL 337
+A + + E+ L+ +LQ Q ++Q + L E + QL+ +L ++ Q+ +
Sbjct: 884 KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943
Query: 338 EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCR 397
+ T + K E++LQ GN + + E +K+ +E EL Q
Sbjct: 944 QNTLKQNEKEEQQLQ-----------GNINELKQSSEQKKK--QIEALQGELKIAVLQKT 990
Query: 398 DLNKRLERETLQS-KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK 456
+L +L+++ Q+ ++ E EK+S EK ++ F + + + Y + L R K
Sbjct: 991 ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Query: 457 QLSQELE--------------SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD 502
+ ++L + I+EL+ ++ LE+ + KE + + + +
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ-DSAKKEQQLQERCKALQDIQ 1109
Query: 503 ERKTMSEKLKKTEDKLQAASSQLQVEQNK-VTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
+ K++ EK E A +++ Q K +T + E+L ++K T++++ +
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLI 1169
Query: 562 KERDDLKNK---LKA--EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN----------- 605
+++ +L+ K LKA E+EK N + + + K E ++K+F++
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE----EELKKEFIEKEAKLHSEIKEK 1225
Query: 606 -----KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE 660
K ++ K T + N + + +E + + ++ +++ DDL E LE
Sbjct: 1226 EVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL---RGEIAVLE 1282
Query: 661 RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD 720
N +D+ + L + + E+ EK +T + L ++L A L RE
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEI------EKLQTKVLE-LQRKLDNTTAAVQELGRENQ 1335
Query: 721 ALKEK 725
+L+ K
Sbjct: 1336 SLQIK 1340
Score = 95.5 bits (236), Expect = 3e-19
Identities = 126/602 (20%), Positives = 253/602 (42%), Gaps = 73/602 (12%)
Query: 253 LTLQRQKIQELTTNAKE-----THTKLALAEAR-VQEEEQKATRLEKELQTQTTKFHQDQ 306
+TL RQ++Q+L + KE K L + + +Q++E K L + + Q
Sbjct: 85 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELE---ETNRSLRK-AEEELQDIKEKISKGE 362
+ + N +QK A L+ +I +++ + RSLR+ AE+++ + E+++K
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEA 204
Query: 363 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK 422
+ E+ + R + D+ +EL++++ ++ ERE+ + KD
Sbjct: 205 TVIQDLKTELLQ-RPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKD---------- 253
Query: 423 RIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT 482
+KL+ + S+ L+ L K QEL+ LK + EL L +
Sbjct: 254 ---ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 483 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 542
++D TKL+ +K + L + + Q S+L + + + +L E+
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 543 ---TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIE 599
T++ + ++VE K + E L+ + + +E+ G L S +N L ++L E
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE--- 427
Query: 600 KDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETL 659
+L + G+ + K+ + Q+V L+LKL ++ E L
Sbjct: 428 -----RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE-------------EQL 469
Query: 660 ERRYANERDKAQFLSK-ELEHVKMELAKYKLAEKTETSHE--QWLFKRLQEEEAKSGHLS 716
+ + N + L K + +H + + + K + + + +++ +++ K +L
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 529
Query: 717 REVDALKEKIHEY-MATEDLICHLQ---GDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
+ KE I EDL +Q G+ +V LNQ + +N L ++ LT++L+
Sbjct: 530 ALLQKSKENISLLEKEREDLYAKIQAGEGETAV----LNQLQEKNHTLQEQVTQLTEKLK 585
Query: 773 RYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAV--INGQLYEE 830
K + +L+ QV ++ A + ++ LE +V +N QL E
Sbjct: 586 NQSESHKQAQENLH------DQVQEQKAHLRAAQDR------VLSLETSVNELNSQLNES 633
Query: 831 SE 832
E
Sbjct: 634 KE 635
Score = 78.6 bits (192), Expect = 3e-14
Identities = 105/507 (20%), Positives = 227/507 (44%), Gaps = 33/507 (6%)
Query: 93 LKAEKMDLALLEAQYGFVTPK--KVLEALQ--RDAFQAKSTPWQEDIY--EKPMNELDKV 146
L+ KM+ L + V K KV ++L+ + F+ ++ + I EK EL
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900
Query: 147 VEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKL 206
++ E+ + +L + + ++ +L+ E +E + ++ + E+E ++L+
Sbjct: 901 LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 207 IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTN 266
I++ +S E+K+++ E LK + + + + + +L +++KI L N
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 267 AKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQK 326
+++ ++ E + ++L++ K Q+ +++ +QN+ +Q+
Sbjct: 1021 YEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL 1080
Query: 327 LAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE---YGNAGIMAEVEELRKRVLDME 383
A + + + + L++ + LQDI+++ S E +AE+EE++ R
Sbjct: 1081 KTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCR----- 1135
Query: 384 GKDEELIKMEEQCRDLNKRLERETLQSKDFK--LEVEKLSKRIMALEKLEDAFNKSKQEC 441
+++E+ K+ E+ + +E KD K L +KL + A + L+ A + K+
Sbjct: 1136 -QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA-DSLKAAVEQEKRNQ 1193
Query: 442 YSLKCNLEKERMTTKQLSQELES-LKVRIKELEAIESRLEKTEFTLKEDLTKLK----TL 496
LK ++KE K+ E E+ L IKE E + E+ E L +T L T+
Sbjct: 1194 QILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTV 1253
Query: 497 TVMFVDERKTMSEKLKKTED---KLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 553
+ ++ +SE K+T+D ++ + +Q Q++ + E R LK + ++
Sbjct: 1254 KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE-------RCLKGEGEI 1306
Query: 554 EEKMYSVTKERDDLKNKLKAEEEKGND 580
E+ V + + L N A +E G +
Sbjct: 1307 EKLQTKVLELQRKLDNTTAAVQELGRE 1333
Score = 70.9 bits (172), Expect = 7e-12
Identities = 92/452 (20%), Positives = 184/452 (40%), Gaps = 79/452 (17%)
Query: 385 KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK--------------LSKRIMALEKL 430
K +++ + ++ +DL L+ E S++ K E+EK ++ L+ L
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSL 140
Query: 431 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLE---------- 480
E +++ E +++K + QL+ E+ +K + E ++ E
Sbjct: 141 EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEEL 200
Query: 481 ----------KTEF----------TLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ- 519
KTE LK++L +++TL ER+ SEKLK KLQ
Sbjct: 201 NKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQS 260
Query: 520 ------AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT-----KERDDLK 568
A SQL+ E K ++E ++ S ++ +K ++T KE+D
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD--- 317
Query: 569 NKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL 628
K EE+ + +S+ N+ Q KD +L S T+LH+ + ++ E
Sbjct: 318 -YTKLEEKHNEESVSKKNIQATLHQ------KDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 629 SQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL---- 684
+ ++LK +++ +E + E++ L+++ + L E+ + +L
Sbjct: 371 GEATQKLK---EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETE 427
Query: 685 -----AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHL 739
A +L E+ + S E+ + K Q + + LSR + LKEK+ + +
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL-KLSRLEEQLKEKVTNSTELQHQLDKT 486
Query: 740 QGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
+ H Q + R+ ++E + +++
Sbjct: 487 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 518
Score = 60.5 bits (145), Expect = 9e-09
Identities = 90/418 (21%), Positives = 181/418 (43%), Gaps = 68/418 (16%)
Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE----LEAIESRLEKTE 483
E + DA N S + + NL +R L QE++ L+ +KE E ++ LEK +
Sbjct: 61 EAVHDAGNDSG---HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ 117
Query: 484 FTLKEDL----------TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVT 533
+++ +L++L ++E +T + +K+ +D + ++QL E +
Sbjct: 118 GLQQQEAKPDGLVTDSSAELQSLEQQ-LEEAQTENFNIKQMKDLFEQKAAQLATE---IA 173
Query: 534 TVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSR-----VNML 588
+ K EE R+L+ E VT+ ++L + ++ +LL R V +L
Sbjct: 174 DIKSKYDEE--RSLR-----EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
Query: 589 KNRLQSLEAI----------EKDFLKN---KLNQDSGKSTTALHQENNKIKELSQEV--- 632
K L ++ + E + LK+ KL S + Q +++ + QEV
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 633 ----ERLKLKLKDM----KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL 684
++LK + ++ + + ++L+K E +Y LE ++ E + + L ++
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 685 AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHS 744
+ ++ S + R+ E ++ G +++ LKE++ E E HL+ +
Sbjct: 347 QQL----QSRLSASETSLHRIHVELSEKGEATQK---LKEELSE---VETKYQHLKAEFK 396
Query: 745 VLQKKLNQQENRNRDLGREIENL-TKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQ 801
LQ++ ++E L EI L +K LE R ++ R++S ++ KE Q
Sbjct: 397 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 122 bits (306), Expect = 2e-27
Identities = 173/773 (22%), Positives = 333/773 (43%), Gaps = 99/773 (12%)
Query: 53 AEKPHSGNGHQAEDLSRDDLLFL------LSILEGELQAR-DEVIG----ILKAEKMDLA 101
+E P GH+ +L+ LL L L+ EL+ D V G ILK EK +
Sbjct: 443 SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR 502
Query: 102 LLEAQYGFVTPKKVLEALQRDAFQAKSTPWQ-EDIYEKPMNE---LDKVVEKHKESYRRI 157
L K +E L+ + Q K + +++ + M E L+K +E +E+ R
Sbjct: 503 L----------SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 158 LGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEK 217
+ L + QT+ L + + E K + E+ K++ + IK K
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVK----------DIEKENKILHESIKETSSK 602
Query: 218 EQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALA 277
+ E +K+EL K + + L L + + +Q+ TN K T K+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKENELLQKKITNLKITCEKIEAL 661
Query: 278 EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL 337
E E E++ +L+K L + + L +L +L ++ +L
Sbjct: 662 EQENSELERENRKLKKTLDSF----------------------KNLTFQLESLEKENSQL 699
Query: 338 EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRK--RVLDMEGKDEELIKMEEQ 395
+E N LR+ E L+ K+++ + N + +E E+L+K +L K E +++ Q
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 396 CRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 455
D+ + ++TL++ + K +++L + LE K+ +E LE+
Sbjct: 760 GLDIENQRLQKTLENSNKK--IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 456 KQLSQELESLKVRIKELEAIESRL----EKTEFTLKEDLTKLKTLTVMFVDERKTMSE-- 509
K L QE L+ K+LE RL E + TL+E+ K+ L E KT+S+
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE----KENKTLSKEI 873
Query: 510 --------KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
+LK+ E + + + ++ + T+ E L+ E + + D+E+ + +
Sbjct: 874 GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE 933
Query: 562 KERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQE 621
K + K +L +E+ +D SR +L+++L+S + + K+ L +
Sbjct: 934 KIGLN-KERLLHDEQSTDD--SRYKLLESKLESTLKKSLEIKEEKI----AALEARLEES 986
Query: 622 NNKIKELSQEVERLKLKLKDMKAIEDD--LMKTEDEYETLERRYANERDKAQFLSKELEH 679
N ++L QE++ +K + +K +D+ ++++ + ++ E +Q ++EL
Sbjct: 987 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE---SQETTRELLK 1043
Query: 680 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK---IHEYMAT-EDL 735
VK L + + T + +Q L +L++ E ++ +L ++ AL+ + + E T +
Sbjct: 1044 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1103
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDL---GREIENLTKELERYRHFSKSLRPSL 785
LQ ++S L + N+N L +EN + + + R KSL SL
Sbjct: 1104 NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
Score = 110 bits (274), Expect = 1e-23
Identities = 156/716 (21%), Positives = 319/716 (44%), Gaps = 95/716 (13%)
Query: 133 EDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSR---RQTILELEEEKRKHKEYMEKS 189
ED E DK+ E KE+ + + +L E R R+ I EL EE + ++S
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422
Query: 190 DEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD-EQQR 248
+ L E E++ + E+ +K +L E+ +L S L+ ++ E Q
Sbjct: 423 MDESLHLGWELEQISR--TSELSEAPQK---------SLGHEVNELTSSRLLKLEMENQS 471
Query: 249 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 308
LT + R + + NA +++ + E++ RL K+++ + Q++ +
Sbjct: 472 LTKTVEELRTTVDSVEGNA-----------SKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 309 IMAKLTNEDSQNRQLQQKLAALSRQIDEL-EETNRSLRKAEEELQDIKEKISKGEYGNAG 367
L N + ++ L ++ A L + I+ L E + R ++ E+E + + + +S +
Sbjct: 521 ----LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQ 575
Query: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
I AE RV D+E +++ L E ++ + +L + + + K E+E ++
Sbjct: 576 ISAEA-----RVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627
Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE---SRLEKTEF 484
E+LE+ + +LEKE + L +++ +LK+ +++EA+E S LE+
Sbjct: 628 EELENELH-----------HLEKE---NELLQKKITNLKITCEKIEALEQENSELERENR 673
Query: 485 TLKEDLTKLKTLTVMFVDERKTMSE------KLKKTEDKLQAAS---SQLQVEQNKVTTV 535
LK+ L K LT K S+ +L++ + L+ AS +QLQ+E ++ +
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733
Query: 536 TEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592
E+L +E K + K +E + E L+ L+ +K L S + L+
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 593 QSLEA-IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 651
Q+L+ +E+ + +K + K +L QE +++++ +++E+ +L+ I+D ++
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 652 --------TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAE-------KTETS 696
E E +TL + ++ L KELE EL K + + +
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVTLREDLV 912
Query: 697 HEQWLFKRLQEEEAKSGHLSREVDALKEK-IHEYMATEDLICHLQGDHSVLQKKLNQQEN 755
E+ +++ + K H ++ KE+ +H+ +T+D + +L+ KL
Sbjct: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD------SRYKLLESKLESTLK 966
Query: 756 RNRDLGRE-IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPP 810
++ ++ E I L LE ++++ LR L + + + ++ + V + PP
Sbjct: 967 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022
Score = 110 bits (274), Expect = 1e-23
Identities = 162/753 (21%), Positives = 327/753 (43%), Gaps = 88/753 (11%)
Query: 61 GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTP-----KKV 115
G +AE+L + L LE E + + I LK + LE + + KK
Sbjct: 624 GERAEELENE-----LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT 678
Query: 116 LEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK-----HKESYRRILGQLLVAEKSRRQ 170
L++ + FQ +S + ++ EL + VE K + ++ + L +EK + +
Sbjct: 679 LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 171 TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
LEL + K E +E S + + + Q ++ + +++I+ E + Q+ E TL++
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 231 ELTKLK--SFALMVVDEQQRLTAQLTLQRQKIQ-ELTTNAKETHTKLALAEARVQEEEQK 287
L +LK S L ++++ + Q T Q +K + +L K + + + ++E K
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 288 ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA 347
LEKE +T + + +++ + +L + +N++L ++ + + L E S +
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Query: 348 EEELQDIKEKISKGEYGNAGIMAE--------VEELRKRVLDMEGKDEELIKM-----EE 394
+++ + EK++ E G+ E ++ R ++L E K E +K EE
Sbjct: 918 TQQMNNDLEKLTH-ELEKIGLNKERLLHDEQSTDDSRYKLL--ESKLESTLKKSLEIKEE 974
Query: 395 QCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMT 454
+ L RLE T ++ + E++ + K AL++ +D + Q + K
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERE 1033
Query: 455 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLT-----VMFVDERKTMSE 509
+++ ++EL +K R+ E+E + L+ + LK L +L+T + +R+T+S
Sbjct: 1034 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS- 1092
Query: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
L++ LQ +++LQVE + + + + L+ + + L ++ +E + SV KER+DLK+
Sbjct: 1093 -LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 570 KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELS 629
+ + ++ E +E L++ +L ++ +K
Sbjct: 1152 -----------------LYDSLIKDHEKLEL------LHERQASEYESLISKHGTLKSAH 1188
Query: 630 QEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAK--- 686
+ +E ++ +D++ + L+K + + E LE+ E++K +K E V E K
Sbjct: 1189 KNLE---VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1245
Query: 687 ------------YKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATED 734
K E +T H+ L L + + L E LKE +Y +
Sbjct: 1246 ENDRLNHTYSQLLKETEVLQTDHKN-LKSLLNNSKLEQTRLEAEFSKLKE---QYQQLDI 1301
Query: 735 LICHLQGDHSVLQKKLNQQENRNRDLGREIENL 767
L +L + E NR L +I+ L
Sbjct: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 1334
Score = 100 bits (248), Expect = 1e-20
Identities = 165/707 (23%), Positives = 312/707 (44%), Gaps = 98/707 (13%)
Query: 184 EYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVV 243
++ME +D + +++ E L K + +K ++ E + + L EE L F
Sbjct: 174 QWMEVTD----MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH-FLPHAS 228
Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 303
Q ++R + ++ H + LA+A+ K RL +EL+ +T +
Sbjct: 229 SSAQSPCGSPGMKRTESRQ--------HLSVELADAKA-----KIRRLRQELEEKTEQ-- 273
Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 363
L + + Q++ +L L ++ L RS R +EL ++EK + +
Sbjct: 274 ---------LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324
Query: 364 GNAGI------MAEVEELRKRVLDMEGKDEELIK----MEEQCRDLNKR------LERET 407
+ + + ++E + RV +++ ++ L++ +E+Q R LE+E
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
Query: 408 LQSK----DFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
LQ K D ++E + K+I L + LE A +S E L LE+ T++
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE 444
Query: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
+SL + EL + SRL K E + LTK VD + + K+ K E + Q
Sbjct: 445 APQKSLGHEVNELTS--SRLLKLEME-NQSLTKTVEELRTTVDSVEGNASKILKMEKENQ 501
Query: 520 AASSQLQVEQNKVTTVTEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE 576
S ++++ +N++ + L +K +K K +E+ + ++ R++ + ++K E+
Sbjct: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL---RENSERQIKILEQ 558
Query: 577 KGNDLLSRVNMLKNRLQ-SLEAIEKDFLK-NKLNQDSGKSTTA-LHQENNKIKELSQEVE 633
+ L V+ L+ R Q S EA KD K NK+ +S K T++ L + + +++ +E+E
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 634 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANER---DKAQFLSKELEHVKMELAKYKLA 690
K K + + +E++L E E E L+++ N + +K + L +E ++ E K K
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-- 676
Query: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750
KT S + F +L+ E ++ L E L+ + E L C K+
Sbjct: 677 -KTLDSFKNLTF-QLESLEKENSQLDEENLELRRNV------ESLKC--------ASMKM 720
Query: 751 NQQENRNRDLGREIENLTKELERYR-HFSKS--LRPSLNGRRISDPQVFS---------K 798
Q + N++L E E L K LE + F K+ L S G I + ++ +
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 799 EVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVL 845
++++E D E + LE I+ + E+ E +++ E S L
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Score = 84.0 bits (206), Expect = 8e-16
Identities = 144/578 (24%), Positives = 248/578 (42%), Gaps = 94/578 (16%)
Query: 54 EKPHSGNGHQAE--DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVT 111
EK + QAE D + ++ + LE E + + IGI K + L LE + +
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 112 PK-----KVLEALQRDAFQAK-STPWQEDIYEKPMNELDKV----------VEKHKESYR 155
+ K L L+ D K T + EK +EL+K+ + +S
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRY 954
Query: 156 RILGQLLVAEKSRRQTILELEEEKRKHKEY-MEKSDEFICLLEQEC-------ERLKKLI 207
++L L +S + LE++EEK E +E+S + L QE E LK+
Sbjct: 955 KLLESKL---ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
Query: 208 DQEIKSQ-------EEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKI 260
D+E Q E+ + E+E + TT EL K+K + V L A+ + ++
Sbjct: 1012 DEERMVQSSPPISGEDNKWERESQETT--RELLKVKDRLIEVERNNATLQAEKQALKTQL 1069
Query: 261 QELTTNAKETHTK-LALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 319
++L T + LAL V +EQ T LQTQ K + T+ ++ T+ +Q
Sbjct: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTT-----LQTQNAKLQVENSTLNSQSTSLMNQ 1124
Query: 320 NRQLQQKLAALS-------RQIDELEETNRSLRKAEEELQDIKEK--------ISK-GEY 363
N QL + ++L ++ ++L+ SL K E+L+ + E+ ISK G
Sbjct: 1125 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184
Query: 364 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKR 423
+A EVE D+E + +L+K + Q DL K L K+E EK+
Sbjct: 1185 KSAHKNLEVEH-----RDLEDRYNQLLKQKGQLEDLEKML----------KVEQEKM--- 1226
Query: 424 IMALEKLEDAFNKSKQECYSLKCNLEKERM--TTKQLSQELESLKVRIKELEAI--ESRL 479
LE+ +++ Y C E +R+ T QL +E E L+ K L+++ S+L
Sbjct: 1227 -----LLENKNHETVAAEYKKLCG-ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280
Query: 480 EKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL 539
E+T L+ + +KLK + S KL + L L+ E + + L
Sbjct: 1281 EQTR--LEAEFSKLKEQ----YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL 1334
Query: 540 IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 577
+ + + L+ + ++ + ++ D N+L+ ++EK
Sbjct: 1335 MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1372
Score = 42.4 bits (98), Expect = 0.003
Identities = 58/248 (23%), Positives = 97/248 (39%), Gaps = 59/248 (23%)
Query: 133 EDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF 192
E ++E+ +E + ++ KH G L A K+ LE E R + D +
Sbjct: 1164 ELLHERQASEYESLISKH--------GTLKSAHKN-------LEVEHR------DLEDRY 1202
Query: 193 ICLLEQ--ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
LL+Q + E L+K++ K ++EK + K T+ E KL E RL
Sbjct: 1203 NQLLKQKGQLEDLEKML----KVEQEKMLLENKNHETVAAEYKKL-------CGENDRLN 1251
Query: 251 ---AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQD 307
+QL + + +Q N K L + R++ E K ++L +TK + +
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1311
Query: 308 TIMAKLTNEDSQNRQLQQKLAALSRQ----------------------IDELEETNRSLR 345
+ N + +NR L ++ L Q ID+L E R
Sbjct: 1312 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1371
Query: 346 KAEEELQD 353
K EE++ D
Sbjct: 1372 KLEEKIMD 1379
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 120 bits (302), Expect = 6e-27
Identities = 148/718 (20%), Positives = 313/718 (43%), Gaps = 88/718 (12%)
Query: 169 RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTL 228
+Q + + E+ +HK+ +E++ + I +E ERLK +E K + E E E K
Sbjct: 1296 KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNY 1355
Query: 229 KEELTKLKSFALMVVDEQQRLTAQLTLQ--------RQKIQELTTNAKETHTKLALAEAR 280
EE+ LK+ ++ + QLT+Q R +I LT + ++ +
Sbjct: 1356 DEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNT 1415
Query: 281 VQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEET 340
+ + + R+E+++Q Q + K E + Q + R L++
Sbjct: 1416 LTQTTENLRRVEEDIQQQKA---TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDA 1472
Query: 341 NRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDME----GKDEELIKMEEQC 396
++++ +E++ +K+ I K + E L++ D++ E + K++ Q
Sbjct: 1473 AKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQE 1532
Query: 397 RDLNK-RLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 455
++L + R++ E + S++ ++ + +++ +L++L+ K ++E LK ++
Sbjct: 1533 QELTRLRIDYERV-SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKR 1591
Query: 456 KQLSQELESLKVRIKE----LEAIESRLEKTEFTLK---EDLTKLKTLTVMFVDERKTMS 508
K+L +ELE ++ +KE + + +LE+ K +DL + + + + E++
Sbjct: 1592 KKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQ 1651
Query: 509 EKLKKTEDKLQAASSQLQVEQNKVTTV------TEKLIEETKRAL-KSKTDV-------- 553
E+L++ +++A QL EQ V +K IE+ R+L +SK ++
Sbjct: 1652 EELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTE 1711
Query: 554 ---------EEKMYSVTKERDDL-KNKLKAEEEKGNDLL---SRVNMLKNRLQSLEAIEK 600
EE++ ++ E DDL + + +A+ +K +L S++ + NR L+ +
Sbjct: 1712 NLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLIN 1771
Query: 601 DFLK---------NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 651
D + K + + +++ + + N+ ++ QE E L +K+K ++ + L +
Sbjct: 1772 DLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR 1831
Query: 652 TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAK 711
EDE + E Q L E + ++ +L ++ KT+ S ++ ++++ E K
Sbjct: 1832 LEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW----KTQYSRKEEAIRKIESEREK 1887
Query: 712 SGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 771
S RE ++L+ +I LQ ++ + E R R R++E+ T+E
Sbjct: 1888 S---EREKNSLRSEIER-----------------LQAEIKRIEERCR---RKLEDSTRET 1924
Query: 772 ERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYE 829
+ +S + P +E QTE L + V QLYE
Sbjct: 1925 QSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYE 1982
Score = 109 bits (273), Expect = 1e-23
Identities = 124/546 (22%), Positives = 249/546 (45%), Gaps = 82/546 (15%)
Query: 164 AEKSRRQTILELE---------EEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQ 214
+E S+R+ LE+E EE ++K+ ++ + + I +E ERLK+LID+E +
Sbjct: 1438 SEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR 1497
Query: 215 EEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKL 274
+ E E R+ ++ +L K S +A T+ + K+QE + T+L
Sbjct: 1498 KCLEDE-NARLQRVQYDLQKANS------------SATETINKLKVQE------QELTRL 1538
Query: 275 ALAEARVQEE----EQKATRLE---KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKL 327
+ RV +E +Q TR + KELQ Q K ++ + + + + + ++L+++L
Sbjct: 1539 RIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL 1598
Query: 328 AALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
+ R + E +L + E+ +K++ + + + L + + + E
Sbjct: 1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKR------SEDDLRQQRDVLDGHLREKQRTQE 1652
Query: 388 ELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSK---QECYSL 444
EL ++ + L ++L +E K L E K A+E + N+SK + SL
Sbjct: 1653 ELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQK---AIEDKSRSLNESKIEIERLQSL 1709
Query: 445 KCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK----TEFTLKEDL-------TKL 493
NL KE + L +EL +L++ +L S + T L+ L +L
Sbjct: 1710 TENLTKEHL---MLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766
Query: 494 KTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTE---------KLIEETK 544
+ L ER+ + ++++K + + AS+++Q +N+ T V + K++E+ K
Sbjct: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
Query: 545 RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK-GNDLLSRVNMLKNRLQSLEAIEKDFL 603
L+ D + S + +K +L+ E+++ NDL + +++ IE +
Sbjct: 1827 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1886
Query: 604 KNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRY 663
K++ ++S +S +I+ L E++R++ + + + +ED +T+ + ET RY
Sbjct: 1887 KSEREKNSLRS---------EIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRY 1935
Query: 664 ANERDK 669
E DK
Sbjct: 1936 QREIDK 1941
Score = 108 bits (271), Expect = 2e-23
Identities = 145/673 (21%), Positives = 288/673 (42%), Gaps = 87/673 (12%)
Query: 101 ALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQ 160
+L EA K +E L+ + + W+ YE NEL KV + E + Q
Sbjct: 1312 SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWE---YE---NELSKVRNNYDEEIISLKNQ 1365
Query: 161 ----LLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKS--- 213
+ + + + Q ++ EE+ ++ ++ L +E +RLK + Q ++
Sbjct: 1366 FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425
Query: 214 -QEEKEQEKE--KRVTTLKEEL-TKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNA-- 267
+E+ +Q+K V+ K++L +L+ M +E R L + IQ+
Sbjct: 1426 VEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIER 1485
Query: 268 ------KETHTKLALAE-----ARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNE 316
KET+ + L + RVQ + QKA +T Q+Q+ ++ E
Sbjct: 1486 LKQLIDKETNDRKCLEDENARLQRVQYDLQKAN--SSATETINKLKVQEQELTRLRIDYE 1543
Query: 317 D-SQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
SQ R ++ + ++R + L+E +K EEEL +K S+ + E+E +
Sbjct: 1544 RVSQERTVKDQ--DITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM 1601
Query: 376 RKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFN 435
R+ + + K L + EQ + KR E + Q +D L + ++ ++
Sbjct: 1602 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV------LDGHLREKQRTQEELR 1655
Query: 436 KSKQECYSLKCNLEKERMTTKQL--------------SQELESLKVRIKELEAIESRLEK 481
+ E +L+ L +E+ + KQ S+ L K+ I+ L+++ L K
Sbjct: 1656 RLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTK 1715
Query: 482 TEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIE 541
L+E+ L+ L + + D R+ SE + SQLQ+ N+ T + LI
Sbjct: 1716 EHLMLEEE---LRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNR-TLELQGLIN 1771
Query: 542 ETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNR-LQSLEAIEK 600
+ +R ER++L+ +++ +++ + +R+ KN+ Q ++ E
Sbjct: 1772 DLQR-----------------ERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERES 1814
Query: 601 DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLK-DMKAIEDDLMKTEDEYETL 659
+K K+ + L E N+ K + R+K +L+ + + I++DL + + +Y
Sbjct: 1815 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRK 1874
Query: 660 E---RRYANERDKAQ----FLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKS 712
E R+ +ER+K++ L E+E ++ E+ ++ E+ E + + E +
Sbjct: 1875 EEAIRKIESEREKSEREKNSLRSEIERLQAEIK--RIEERCRRKLEDSTRETQSQLETER 1932
Query: 713 GHLSREVDALKEK 725
RE+D L+++
Sbjct: 1933 SRYQREIDKLRQR 1945
Score = 73.9 bits (180), Expect = 8e-13
Identities = 133/668 (19%), Positives = 278/668 (41%), Gaps = 84/668 (12%)
Query: 145 KVVEKHKESYRRILGQLLVAEKSRRQTILE-------------LEEEKRKHKEYMEKSDE 191
K + ++++Y+ L A+ RRQ LE L E+K H E K D+
Sbjct: 886 KQLRNYRDNYQAFCKWLYDAK--RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDK 943
Query: 192 FICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE---ELTKLKSFALMVVDEQQR 248
+E +++ +L IK E + + TL + T ++S + +++ E
Sbjct: 944 -----SEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
Query: 249 LTAQ----LTLQRQKIQELTTNAKETHT-KLALAEARVQEEEQKATRLEKELQTQTTKFH 303
+ A+ LT + L+ K KL + V EEE RL ++ ++ +
Sbjct: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEE---LRLARDANSENCNKN 1055
Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQID-ELEETNRSLRKAEEELQDIKEKISKGE 362
+ D + K E SQ + L L RQ + + + ++L K +++++ EKI++
Sbjct: 1056 KFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLT 1115
Query: 363 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK 422
Y E+E+ ++R +E + ++ +Q + ++ E+E L + KLE EK
Sbjct: 1116 Y-------EIEDEKRRRKSVEDRFDQQKNDYDQLQKA-RQCEKENLGWQ--KLESEK--- 1162
Query: 423 RIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKT 482
A + + E L+ L++E T++ E E KVR E + + K
Sbjct: 1163 ----------AIKEKEYEIERLRVLLQEEG--TRKREYENELAKVRNHYNEEMSNLRNKY 1210
Query: 483 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 542
E + T +K +++ D+ K + +L + + + ++ + + TE+
Sbjct: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRA 1270
Query: 543 TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKG----NDLLSRVNMLKNRLQSLEAI 598
+ AL+ K E M +LK ++ E L ++++ + +E +
Sbjct: 1271 EENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERL 1330
Query: 599 EKDFLKNKLNQDSGKSTTALHQENNKIK-ELSQEVERLKLKLKDMKAIEDDLMKTEDEYE 657
+ +F Q+ K E +K++ +E+ + LK+ E ++ KT
Sbjct: 1331 KAEF------QEEAKRRWEYENELSKVRNNYDEEI----ISLKNQFETEINITKTTIHQL 1380
Query: 658 TLERRYANERDKAQF--LSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHL 715
T+++ +AQ L++E + E+ + K T + + + + +Q+++A +
Sbjct: 1381 TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV 1440
Query: 716 SREVDALKEKIHE--YMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 773
S+ L+ ++ + M TE+ + + Q L+ +D +EIE L + +++
Sbjct: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQ--------SLDDAAKTIQDKNKEIERLKQLIDK 1492
Query: 774 YRHFSKSL 781
+ K L
Sbjct: 1493 ETNDRKCL 1500
Score = 52.4 bits (124), Expect = 2e-06
Identities = 103/557 (18%), Positives = 208/557 (37%), Gaps = 119/557 (21%)
Query: 333 QIDELEETNRSLRKAEEELQDIKEKIS--KGEYGNAGIMAEVEELRKRVLDMEGKDE--- 387
+I+EL+ + E L +K+ ++ +G + EV L +++ ++ G +
Sbjct: 705 KINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYL 764
Query: 388 -------ELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQE 440
L++ Q D+ K E + + L+++K+ L+K+++ N K
Sbjct: 765 NSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSL 824
Query: 441 CYSLKCNLEKERMTTKQLSQE--------------------------------LESLKVR 468
++K L+K + Q SQ+ L L+ +
Sbjct: 825 LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ 884
Query: 469 IKELEAIESRLE---KTEFTLKEDLTKLKTL------TVM-FVDERKTMSEKLKKTEDKL 518
IK+L + K + K L+++ TVM F++E+K + ++ DK
Sbjct: 885 IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS 944
Query: 519 QAASSQLQVEQNKVTTVTEKLIEET-----------KRA---------LKSKTDVEEK-- 556
+ ++ N + +L T KR L+ DV +
Sbjct: 945 EEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYI 1004
Query: 557 ------------MYSVTKERDDLKNK----------LKAEEEKGNDLLSRVNMLKNRLQS 594
+ + K +DLK K L+ + ++ ++ L LQ
Sbjct: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQK 1064
Query: 595 LEAIEKDF---------LKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD---- 641
+A F LK + D + L + +IKEL++++ RL +++D
Sbjct: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRR 1124
Query: 642 MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWL 701
K++ED + +++Y+ L++ E++ + E E E +Y++ E+
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKE-KEYEIERLRVLLQEEGT 1183
Query: 702 FKRLQEEEAKS--GHLSREVDALKEKIHEYM-----ATEDLICHLQGDHSVLQKKLNQQE 754
KR E E H + E+ L+ K + +++ + D L+ +L++
Sbjct: 1184 RKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
Query: 755 NRNRDLGREIENLTKEL 771
NRDL EI L +
Sbjct: 1244 RENRDLKDEIVRLNDSI 1260
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 120 bits (301), Expect = 7e-27
Identities = 171/773 (22%), Positives = 330/773 (42%), Gaps = 100/773 (12%)
Query: 53 AEKPHSGNGHQAEDLSRDDLLFL------LSILEGELQAR-DEVIG----ILKAEKMDLA 101
+E P GH+ +L+ LL L L+ EL+ D V G ILK EK +
Sbjct: 443 SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR 502
Query: 102 LLEAQYGFVTPKKVLEALQRDAFQAKSTPWQ-EDIYEKPMNE---LDKVVEKHKESYRRI 157
L K +E L+ + Q K + +++ + M E L+K +E +E+ R
Sbjct: 503 L----------SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQ 552
Query: 158 LGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEK 217
+ L + QT+ L + + E K + E+ K++ + IK K
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVK----------DIEKENKILHESIKETSSK 602
Query: 218 EQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALA 277
+ E +K+EL K + + L L + + +Q+ TN K T K+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELH-HLEKENELLQKKITNLKITCEKIEAL 661
Query: 278 EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL 337
E E E++ +L+K L + + L +L +L ++ +L
Sbjct: 662 EQENSELERENRKLKKTLDSF----------------------KNLTFQLESLEKENSQL 699
Query: 338 EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRK--RVLDMEGKDEELIKMEEQ 395
+E N LR+ E L+ K+++ + N + +E E+L+K +L K E +++ Q
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 396 CRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 455
D+ + ++TL++ + K +++L + LE K+ +E LE+
Sbjct: 760 GLDIENQRLQKTLENSNKK--IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN 817
Query: 456 KQLSQELESLKVRIKELEAIESRL----EKTEFTLKEDLTKLKTLTVMFVDERKTMSE-- 509
K L QE L+ K+LE RL E + TL+E+ K+ L E KT+S+
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE----KENKTLSKEI 873
Query: 510 --------KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 561
+LK+ E + + + ++ + T+ E L+ E + + D+E+ + +
Sbjct: 874 GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL- 932
Query: 562 KERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQE 621
E+ L + +E+ D R +L+++L+S + + K+ L +
Sbjct: 933 -EKIGLNKERLLHDEQSTD--DRYKLLESKLESTLKKSLEIKEEKI----AALEARLEES 985
Query: 622 NNKIKELSQEVERLKLKLKDMKAIEDD--LMKTEDEYETLERRYANERDKAQFLSKELEH 679
N ++L QE++ +K + +K +D+ ++++ + ++ E +Q ++EL
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE---SQETTRELLK 1042
Query: 680 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK---IHEYMAT-EDL 735
VK L + + T + +Q L +L++ E ++ +L ++ AL+ + + E T +
Sbjct: 1043 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1102
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDL---GREIENLTKELERYRHFSKSLRPSL 785
LQ ++S L + N+N L +EN + + + R KSL SL
Sbjct: 1103 NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1155
Score = 112 bits (280), Expect = 2e-24
Identities = 157/749 (20%), Positives = 323/749 (43%), Gaps = 81/749 (10%)
Query: 61 GHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTP-----KKV 115
G +AE+L + L LE E + + I LK + LE + + KK
Sbjct: 624 GERAEELENE-----LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKT 678
Query: 116 LEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEK-----HKESYRRILGQLLVAEKSRRQ 170
L++ + FQ +S + ++ EL + VE K + ++ + L +EK + +
Sbjct: 679 LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK 738
Query: 171 TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKE 230
LEL + K E +E S + + + Q ++ + +++I+ E + Q+ E TL++
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 231 ELTKLK--SFALMVVDEQQRLTAQLTLQRQKIQ-ELTTNAKETHTKLALAEARVQEEEQK 287
L +LK S L ++++ + Q T Q +K + +L K + + + ++E K
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 288 ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQK----LAALSRQIDELEETNRS 343
LEKE +T + + +++ + +L + +N++L ++ + L ++L
Sbjct: 859 IGNLEKENKTLSKEIGIYKESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
Query: 344 LRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM-----EEQCRD 398
++ +L+ + ++ K ++ + + R +E K E +K EE+
Sbjct: 918 TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977
Query: 399 LNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQL 458
L RLE T ++ + E++ + K AL++ +D + Q + K +++
Sbjct: 978 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQET 1036
Query: 459 SQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLT-----VMFVDERKTMSEKLKK 513
++EL +K R+ E+E + L+ + LK L +L+T + +R+T+S L++
Sbjct: 1037 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS--LQE 1094
Query: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
LQ +++LQVE + + + + L+ + + L ++ +E + SV KER+DLK+
Sbjct: 1095 QNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS---- 1150
Query: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
+ + ++ E +E L++ +L ++ +K + +E
Sbjct: 1151 -------------LYDSLIKDHEKLEL------LHERQASEYESLISKHGTLKSAHKNLE 1191
Query: 634 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAK------- 686
++ +D++ + L+K + + E LE+ E++K +K E V E K
Sbjct: 1192 ---VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1248
Query: 687 --------YKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH 738
K E +T H+ L L + + L E LKE +Y +
Sbjct: 1249 LNHTYSQLLKETEVLQTDHKN-LKSLLNNSKLEQTRLEAEFSKLKE---QYQQLDITSTK 1304
Query: 739 LQGDHSVLQKKLNQQENRNRDLGREIENL 767
L +L + E NR L +I+ L
Sbjct: 1305 LNNQCELLSQLKGNLEEENRHLLDQIQTL 1333
Score = 110 bits (275), Expect = 8e-24
Identities = 156/713 (21%), Positives = 320/713 (44%), Gaps = 90/713 (12%)
Query: 133 EDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSR---RQTILELEEEKRKHKEYMEKS 189
ED E DK+ E KE+ + + +L E R R+ I EL EE + ++S
Sbjct: 364 EDQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422
Query: 190 DEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD-EQQR 248
+ L E E++ + E+ +K +L E+ +L S L+ ++ E Q
Sbjct: 423 MDESLHLGWELEQISR--TSELSEAPQK---------SLGHEVNELTSSRLLKLEMENQS 471
Query: 249 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDT 308
LT + R + + NA +++ + E++ RL K+++ + Q++ +
Sbjct: 472 LTKTVEELRTTVDSVEGNA-----------SKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 309 IMAKLTNEDSQNRQLQQKLAALSRQIDEL-EETNRSLRKAEEELQDIKEKISKGEYGNAG 367
L N + ++ L ++ A L + I+ L E + R ++ E+E + + + +S +
Sbjct: 521 ----LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQ 575
Query: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
I AE RV D+E +++ L E ++ + +L + + + K E+E ++
Sbjct: 576 ISAEA-----RVKDIEKENKIL---HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627
Query: 428 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIE---SRLEKTEF 484
E+LE+ + +LEKE + L +++ +LK+ +++EA+E S LE+
Sbjct: 628 EELENELH-----------HLEKE---NELLQKKITNLKITCEKIEALEQENSELERENR 673
Query: 485 TLKEDLTKLKTLTVMFVDERKTMSE------KLKKTEDKLQAAS---SQLQVEQNKVTTV 535
LK+ L K LT K S+ +L++ + L+ AS +QLQ+E ++ +
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733
Query: 536 TEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRL 592
E+L +E K + K +E + E L+ L+ +K L S + L+
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 593 QSLEA-IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMK 651
Q+L+ +E+ + +K + K +L QE +++++ +++E+ +L+ I+D ++
Sbjct: 794 QTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 652 --------TEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAE-KTETSHEQWLF 702
E E +TL + ++ L KELE EL K + KT + L
Sbjct: 854 ENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVT----LR 908
Query: 703 KRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH----LQGDHSVLQKKLNQQENRNR 758
+ L E+ K+ ++ +++ L ++ + ++ + H + +L+ KL ++
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968
Query: 759 DLGRE-IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPP 810
++ E I L LE ++++ LR L + + + ++ + V + PP
Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1021
Score = 100 bits (248), Expect = 1e-20
Identities = 165/707 (23%), Positives = 312/707 (44%), Gaps = 98/707 (13%)
Query: 184 EYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVV 243
++ME +D + +++ E L K + +K ++ E + + L EE L F
Sbjct: 174 QWMEVTD----MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH-FLPHAS 228
Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 303
Q ++R + ++ H + LA+A+ K RL +EL+ +T +
Sbjct: 229 SSAQSPCGSPGMKRTESRQ--------HLSVELADAKA-----KIRRLRQELEEKTEQ-- 273
Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 363
L + + Q++ +L L ++ L RS R +EL ++EK + +
Sbjct: 274 ---------LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324
Query: 364 GNAGI------MAEVEELRKRVLDMEGKDEELIK----MEEQCRDLNKR------LERET 407
+ + + ++E + RV +++ ++ L++ +E+Q R LE+E
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
Query: 408 LQSK----DFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLS 459
LQ K D ++E + K+I L + LE A +S E L LE+ T++
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE 444
Query: 460 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
+SL + EL + SRL K E + LTK VD + + K+ K E + Q
Sbjct: 445 APQKSLGHEVNELTS--SRLLKLEME-NQSLTKTVEELRTTVDSVEGNASKILKMEKENQ 501
Query: 520 AASSQLQVEQNKVTTVTEKL---IEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE 576
S ++++ +N++ + L +K +K K +E+ + ++ R++ + ++K E+
Sbjct: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL---RENSERQIKILEQ 558
Query: 577 KGNDLLSRVNMLKNRLQ-SLEAIEKDFLK-NKLNQDSGKSTTA-LHQENNKIKELSQEVE 633
+ L V+ L+ R Q S EA KD K NK+ +S K T++ L + + +++ +E+E
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 634 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANER---DKAQFLSKELEHVKMELAKYKLA 690
K K + + +E++L E E E L+++ N + +K + L +E ++ E K K
Sbjct: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-- 676
Query: 691 EKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKL 750
KT S + F +L+ E ++ L E L+ + E L C K+
Sbjct: 677 -KTLDSFKNLTF-QLESLEKENSQLDEENLELRRNV------ESLKC--------ASMKM 720
Query: 751 NQQENRNRDLGREIENLTKELERYR-HFSKS--LRPSLNGRRISDPQVFS---------K 798
Q + N++L E E L K LE + F K+ L S G I + ++ +
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 799 EVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVL 845
++++E D E + LE I+ + E+ E +++ E S L
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Score = 85.1 bits (209), Expect = 3e-16
Identities = 146/574 (25%), Positives = 250/574 (43%), Gaps = 87/574 (15%)
Query: 54 EKPHSGNGHQAE--DLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVT 111
EK + QAE D + ++ + LE E + + IGI K + L LE + +
Sbjct: 835 EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV 894
Query: 112 PK-----KVLEALQRDAFQAK-STPWQEDIYEKPMNELDKV-VEK----HKESYRRILGQ 160
+ K L L+ D K T + EK +EL+K+ + K H E +
Sbjct: 895 KRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYK 954
Query: 161 LLVAE-KSRRQTILELEEEKRKHKEY-MEKSDEFICLLEQEC-------ERLKKLIDQEI 211
LL ++ +S + LE++EEK E +E+S + L QE E LK+ D+E
Sbjct: 955 LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1014
Query: 212 KSQ-------EEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELT 264
Q E+ + E+E + TT EL K+K + V L A+ + ++++L
Sbjct: 1015 MVQSSPPISGEDNKWERESQETT--RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE 1072
Query: 265 TNAKETHTK-LALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQL 323
T + LAL V +EQ T LQTQ K + T+ ++ T+ +QN QL
Sbjct: 1073 TQNNNLQAQILALQRQTVSLQEQNTT-----LQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 324 QQKLAALS-------RQIDELEETNRSLRKAEEELQDIKEK--------ISK-GEYGNAG 367
+ ++L ++ ++L+ SL K E+L+ + E+ ISK G +A
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1187
Query: 368 IMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL 427
EVE D+E + +L+K + Q DL K L K+E EK+
Sbjct: 1188 KNLEVEH-----RDLEDRYNQLLKQKGQLEDLEKML----------KVEQEKM------- 1225
Query: 428 EKLEDAFNKSKQECYSLKCNLEKERM--TTKQLSQELESLKVRIKELEAI--ESRLEKTE 483
LE+ +++ Y C E +R+ T QL +E E L+ K L+++ S+LE+T
Sbjct: 1226 -LLENKNHETVAAEYKKLCG-ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTR 1283
Query: 484 FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEET 543
L+ + +KLK + S KL + L L+ E + + L+ +
Sbjct: 1284 --LEAEFSKLKEQ----YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQN 1337
Query: 544 KRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 577
+ L+ + ++ + ++ D N+L+ ++EK
Sbjct: 1338 RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1371
Score = 42.4 bits (98), Expect = 0.003
Identities = 58/248 (23%), Positives = 97/248 (39%), Gaps = 59/248 (23%)
Query: 133 EDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEF 192
E ++E+ +E + ++ KH G L A K+ LE E R + D +
Sbjct: 1163 ELLHERQASEYESLISKH--------GTLKSAHKN-------LEVEHR------DLEDRY 1201
Query: 193 ICLLEQ--ECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
LL+Q + E L+K++ K ++EK + K T+ E KL E RL
Sbjct: 1202 NQLLKQKGQLEDLEKML----KVEQEKMLLENKNHETVAAEYKKL-------CGENDRLN 1250
Query: 251 ---AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQD 307
+QL + + +Q N K L + R++ E K ++L +TK + +
Sbjct: 1251 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1310
Query: 308 TIMAKLTNEDSQNRQLQQKLAALSRQ----------------------IDELEETNRSLR 345
+ N + +NR L ++ L Q ID+L E R
Sbjct: 1311 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1370
Query: 346 KAEEELQD 353
K EE++ D
Sbjct: 1371 KLEEKIMD 1378
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 119 bits (298), Expect = 2e-26
Identities = 142/683 (20%), Positives = 311/683 (45%), Gaps = 60/683 (8%)
Query: 54 EKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPK 113
E SG H ED + L EL+A+ I IL +K +L + A Y
Sbjct: 97 ETTTSGGCHSPEDEQKASHQHQ-EALRRELEAQVHTIRILTCQKTELQM--ALYYSQHAV 153
Query: 114 KVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTIL 173
K LE RD W+ + + + V K+ R + +L K R L
Sbjct: 154 KQLEGEARDLISRLHDSWK---FAGELEQALSAVATQKKKADRYIEELT---KERDALSL 207
Query: 174 ELEEEKRKHKEYMEKS---DEFICLLEQECERLKKLIDQEIKSQEEK------EQEKEKR 224
EL +E EK+ E + L+E E ++ + +E+K + E+ +Q+ +
Sbjct: 208 ELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV-KELKRKLERAKLLLPQQQLQAE 266
Query: 225 VTTLKEELTKLKSFALMVVDEQQ---RLTAQ----LTLQRQKIQELTTNAKETHTKLALA 277
L +EL + + V+E + RL Q + Q +KIQE +E K+
Sbjct: 267 ADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ 326
Query: 278 EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL 337
E +++E+E+K R E+ + + K + ++ + K Q + +K + RQ + +
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 386
Query: 338 EETNRSLRKAEEELQDIKEKISKGE--YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQ 395
E +R+ EE++ + +EKI + E + E E+ +++ M ++E++ + EE+
Sbjct: 387 WEKEEKIRELEEKMHE-QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 396 CRDLNKRL--------ERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 447
R+ K++ E+E ++ ++ + E E++ ++ + + E+ + + K++ + +
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW-RQKEKMHEQE-- 502
Query: 448 LEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTM 507
EK R +++ ++ E ++ + +++ E ++ + E ++E + M E+
Sbjct: 503 -EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWE 561
Query: 508 SEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDL 567
EK ++ EDK+ +++ ++ KV EK+ E+ ++ + + EEKM+ ++ +
Sbjct: 562 EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK----RQEQEEKMWKQEEKIREQ 617
Query: 568 KNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKE 627
+ K++ +EE K R Q + E++ + + + G+ + ++ K++E
Sbjct: 618 EEKIQEQEE------------KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Query: 628 LSQEVERLKLKLKDM-KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAK 686
+ + R + K+++ K I + K ++ E ++ + ++ + + ++ E KM+ +
Sbjct: 666 QEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE--KMQEQE 723
Query: 687 YKLAEKTETSHEQWLFKRLQEEE 709
K+ + E EQ + R QEE+
Sbjct: 724 EKMRRQEEKMWEQEVRLRQQEEK 746
Score = 107 bits (267), Expect = 6e-23
Identities = 140/687 (20%), Positives = 311/687 (45%), Gaps = 89/687 (12%)
Query: 145 KVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLK 204
K +H+E+ RR L +++ TI L +K + + + S + LE E L
Sbjct: 112 KASHQHQEALRREL-------EAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 164
Query: 205 KLIDQEIKSQEEKEQE------KEKRVTTLKEELTK------LKSFALMVVDEQ-----Q 247
+ K E EQ ++K+ EELTK L+ + + DE+
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 224
Query: 248 RLTAQLTLQRQKIQELTTNAKETHTKLALAEARV--QEEEQKATRLEKELQTQTTKFHQD 305
+L +L L + E+ N KE KL A+ + Q+ + +A L KELQ+ + K
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAK---- 280
Query: 306 QDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYG- 364
+ A++ + NR QQ+ + RQ ++++E +++ EE++++ +EKI + E
Sbjct: 281 ---LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 365 --NAGIMAEVEELRKRVLDMEG-KDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLS 421
+M E EE +R +M K+E++ + EE + +++ R+ + + ++ +L
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 397
Query: 422 KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK 481
+++ EK+ + K ++E EK R K+ QE + + K E E ++ +
Sbjct: 398 EKMHEQEKIREQEEKRQEE--------EKIREQEKRQEQEAKMWRQEEKIREQ-EEKIRE 448
Query: 482 TEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIE 541
E + K+ + +E++ E++ + E+K+ EQ ++ EK+ E
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIH--------EQEEIWRQKEKMHE 500
Query: 542 ETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK---GNDLLSRVNMLKNRLQSLEAI 598
+ ++ K EEK++ ++ + + K++ +EEK + + + + +
Sbjct: 501 QEEKIRKQ----EEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ 556
Query: 599 EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYET 658
EK + + K + K + ++ KI+E ++V R + K+++ + K +++ E
Sbjct: 557 EKIWEEEKRQEQEDK----MWRQEEKIREQEEKVWRQEEKIREQEE------KRQEQEEK 606
Query: 659 LERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSRE 718
+ ++ R++ + + ++ E ++ + + K+ E+ E + QE+E K G +
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQ--EEKIREQEEMT---------QEQEEKMGEQEEK 655
Query: 719 VDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRD----LGREIENLTKELERY 774
+ +EK+ E E+ + + +KK+ +QE + R+ + + E + ++ E+
Sbjct: 656 MCEQEEKMQEQ---EETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 712
Query: 775 RHFSKSLRPSLNGRRISDPQVFSKEVQ 801
+ ++ R + +++ +EV+
Sbjct: 713 CEQEEKMQEQEEKMRRQEEKMWEQEVR 739
Score = 107 bits (267), Expect = 6e-23
Identities = 98/478 (20%), Positives = 228/478 (47%), Gaps = 44/478 (9%)
Query: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
+ K W+E I E+ EK +E +I Q EK RRQ + E+E++
Sbjct: 306 EEKIQEWEEKIQEQE--------EKIREQEEKIREQ---EEKMRRQEEMMWEKEEK---- 350
Query: 185 YMEKSDEFICLLEQECERLKKLI---DQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALM 241
M + +E + E++ R ++++ +++++ QEE EKE+++ L+E++ +
Sbjct: 351 -MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHE------- 402
Query: 242 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTK 301
E+ R + + +KI+E +E K+ E +++E+E+K EK++ Q K
Sbjct: 403 --QEKIREQEEKRQEEEKIRE-QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 459
Query: 302 FHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 361
H+ + + + RQ Q+++ +I E EE R K E+ + I+++ K
Sbjct: 460 IHEQEKI-------REEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKV 512
Query: 362 EYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLS 421
I + E++R++ M ++E++ + EE R+ K E+E + ++ + E E
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQE--D 570
Query: 422 KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK 481
K EK+ + K ++ ++ EK + +++ ++ E ++ + ++++ E ++ +
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630
Query: 482 TEFTLKEDLTKLKTLTVMFVDERKTM---SEKLKKTEDKLQAASSQLQVEQNKVTTVTEK 538
E ++E + ++ + M EK+++ E+ + +++ ++ K+ EK
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEK 690
Query: 539 LIEETKRALKSKTDV---EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQ 593
+ E+ + + + + EEKM ++ + + K++ +EEK + R+ + ++Q
Sbjct: 691 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 64.3 bits (155), Expect = 6e-10
Identities = 55/241 (22%), Positives = 122/241 (50%), Gaps = 34/241 (14%)
Query: 120 QRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEK 179
Q + + + W+E E+ M+E +K+ E+ K + +K RQ EE+
Sbjct: 536 QEEKIREQEEMWRE---EEKMHEQEKIWEEEKRQEQE--------DKMWRQ-----EEKI 579
Query: 180 RKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRV----TTLKEELTKL 235
R+ +E + + +E I EQE +R ++ ++++ QEEK +E+E+++ ++E+ K+
Sbjct: 580 REQEEKVWRQEEKI--REQEEKRQEQ--EEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635
Query: 236 KSFALMVVDEQQRLTAQ---LTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE 292
+ M ++++++ Q + Q +K+QE K+ E +++E+E+K E
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQE 695
Query: 293 KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
+ +Q Q K + ++ + Q ++Q++ + RQ +++ E LR+ EE++Q
Sbjct: 696 EMMQEQEEKMWEQEEKMC-------EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Query: 353 D 353
+
Sbjct: 749 E 749
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 119 bits (297), Expect = 2e-26
Identities = 138/680 (20%), Positives = 302/680 (44%), Gaps = 91/680 (13%)
Query: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
R K PW + ++ + L K E KE + ++ ++++E
Sbjct: 825 RSFMNVKHWPWMKLFFK--IKPLLKSAETEKEM------------ATMKEEFQKIKDELA 870
Query: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
K + ++ +E + L +E L+ + E + + E+ ++ + T + K+K
Sbjct: 871 KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTE 930
Query: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
DE++ + A+LT +++K+++ + K+ L L A+V++E+ K L T
Sbjct: 931 RAEDEEE-INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL----T 985
Query: 301 KFHQDQDTIMAKLTNEDSQNRQL-QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
+ D +AKLT E ++ QQ L L + D++ ++ K E+++ D++ +
Sbjct: 986 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045
Query: 360 KG-------EYGNAGIMAEVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRLERETL 408
+ E + +++ ++ ++D+E + DE+L K E + +L ++E E
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQA 1105
Query: 409 QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE----- 463
+ ++++L RI LE+ +A S+ + + +L +E +++S+ LE
Sbjct: 1106 LGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE---LEEISERLEEAGGA 1162
Query: 464 -SLKVRI---KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
S ++ + +E E + R + E TL+ + T TL D + E++ D LQ
Sbjct: 1163 TSAQIEMNKKREAEFQKMRRDLEEATLQHEAT-AATLRKKHADSVAELGEQI----DNLQ 1217
Query: 520 AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
+L+ E++++ + L + K+K ++E+ + + +D ++LK++EE+
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK----MCRTLEDQLSELKSKEEEQQ 1273
Query: 580 DLLSRVNMLKNRLQ------SLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
L++ + + RLQ S + EK+ L ++L++ T +I+EL +++E
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT-------QQIEELKRQLE 1326
Query: 634 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKT 693
++K A+ L + + + L +Y E++ L + L E+A+++
Sbjct: 1327 E---EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR----- 1378
Query: 694 ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 753
T +E +R +E E L++ + A +E + + K
Sbjct: 1379 -TKYETDAIQRTEELEEAKKKLAQRLQAAEEHV-----------------EAVNAKCASL 1420
Query: 754 ENRNRDLGREIENLTKELER 773
E + L E+E+L ++ER
Sbjct: 1421 EKTKQRLQNEVEDLMLDVER 1440
Score = 116 bits (290), Expect = 1e-25
Identities = 176/846 (20%), Positives = 361/846 (42%), Gaps = 144/846 (17%)
Query: 82 ELQAR-DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
ELQAR +E+ ++AE+ A E Q ++ +++ E +R +T Q ++ +K
Sbjct: 1116 ELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQIEMNKKRE 1174
Query: 141 NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
E K+ +E+ + K ++ EL E+ + +K LE+E
Sbjct: 1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK-------LEKEK 1227
Query: 201 ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
+K ID + E + K EK TL+++L++LKS +EQQRL LT QR
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE----EEQQRLINDLTAQR 1283
Query: 258 QKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKELQTQTTKFH------ 303
++Q E +++ K AL +A Q+ E+ +LE+E++ + H
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR 1343
Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSLRK-- 346
D D + + E +LQ+ L+ + ++ +ELEE + L +
Sbjct: 1344 HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403
Query: 347 --AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 404
AEE ++ + K + E + EVE+L +LD+E + ++++ R+ +K L
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---MLDVERTNAACAALDKKQRNFDKILA 1460
Query: 405 RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC---NLEKERMT-TK 456
+ ++ E+E K +L K+++A+ +S + +LK NL++E T+
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 457 QLSQ------ELESLKVRIKE--------LEAIESRLE----------------KTEFTL 486
Q+++ ELE +K ++++ LE E+ LE K+E
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 487 K-----EDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQAASSQLQVEQNKVTT 534
K E++ +LK + V+ + T+ +++ D K++ ++++++ N
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640
Query: 535 VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 594
+ + + + D + + + ++DLK +L E + N L + + L+ L+
Sbjct: 1641 MAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700
Query: 595 LEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLKLKLKDM-------- 642
E K + L D+ + LH +N + K+L ++ +++ +++D+
Sbjct: 1701 TERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE 1758
Query: 643 ----KAIED------DLMKTEDEYETLERRYANER----------DKAQFLS-----KEL 677
KAI D +L K +D LER N D+A+ L+ K++
Sbjct: 1759 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818
Query: 678 EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
+ ++ + + + ++E K L++ E + L+ + + ++ I + +DL+
Sbjct: 1819 QKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI---LRLQDLVD 1875
Query: 738 HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFS 797
LQ +++ + E ++ + L ELE + +N R+ +V +
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHT 1935
Query: 798 KEVQTE 803
K + E
Sbjct: 1936 KVISEE 1941
Score = 112 bits (280), Expect = 2e-24
Identities = 122/547 (22%), Positives = 255/547 (46%), Gaps = 73/547 (13%)
Query: 287 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 346
K+ EKE+ T +F + +D +L +++ ++L++K+ L ++ ++L+ ++
Sbjct: 847 KSAETEKEMATMKEEFQKIKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQA 899
Query: 347 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 401
E L D +E+ + + A+++E+ +R D E + EL K+E++C +L K
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 959
Query: 402 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 447
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 448 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD-E 503
+K TK +L Q+++ L+ +++ + + LE+ + L+ DL KL ++M ++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENE 1078
Query: 504 RKTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 553
++ + EKLKK E ++ QA QLQ + ++ E+L EE + S+
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138
Query: 554 EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK 613
E++ +++E +++ +L EE G +++ M K R + + +D L+ Q
Sbjct: 1139 EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRD-LEEATLQHEAT 1194
Query: 614 STTALHQENNKIKELSQEV---ERLKLKLK----DMKAIEDDLMKTEDEYETLERRYANE 666
+ T + + + EL +++ +R+K KL+ +MK DDL ET+ + N
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL---ASNVETVSKAKGNL 1251
Query: 667 RDKAQFLSKELEHVK------MELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSR-- 717
+ L +L +K L A++ E F R L E+EA LSR
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 718 -----EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLT 768
+++ LK ++ E + ++ + H + D +L+++ +++ +L R +
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 769 KELERYR 775
E+ ++R
Sbjct: 1372 TEVAQWR 1378
Score = 102 bits (254), Expect = 2e-21
Identities = 160/738 (21%), Positives = 323/738 (43%), Gaps = 105/738 (14%)
Query: 82 ELQARDEVIGILKAEKMDLALLEAQYGFVTP-KKVLE-ALQRDAFQAKSTPWQEDIYEKP 139
+LQ + E G+ AE+ L++ + K+V E A + A+ T + + E
Sbjct: 894 QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL-EDE 952
Query: 140 MNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQE 199
+EL K ++ + + ++ EK + T E + + E M DE I L +E
Sbjct: 953 CSELKKDIDDLELTLAKV-------EKEKHAT----ENKVKNLTEEMAGLDETIAKLTKE 1001
Query: 200 CERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQK 259
KK + + + + Q +E +V TL + KL+ VD+ L L +++
Sbjct: 1002 ----KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ----QVDD---LEGSLEQEKKL 1050
Query: 260 IQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 319
+L ++ L LA+ + + E + +L+++L+ + + + +K+ +E +
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI----SNLQSKIEDEQAL 1106
Query: 320 NRQLQQKLAALSRQIDELEETNRSLR----KAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
QLQ+K+ L +I+ELEE + R KAE++ D+ E+EE+
Sbjct: 1107 GIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR--------------ELEEI 1152
Query: 376 RKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
+R+ + G I+M E + + + + LE TLQ + + K K ++ +L
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK--KHADSVAELG 1210
Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT 491
+ + ++ +K LEKE+ ++ E++ L ++ + + LEK TL++ L+
Sbjct: 1211 EQIDNLQR----VKQKLEKEK---SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS 1263
Query: 492 KLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKT 551
+L K+ E+ ++ + L A +LQ E + + ++ K AL S+
Sbjct: 1264 EL-----------KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE-----KEALVSQL 1307
Query: 552 DVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EAIEKDFLKNKLNQ 609
++ + T++ ++LK +L+ E + N L + ++ L + E+ K +L +
Sbjct: 1308 SRGKQAF--TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365
Query: 610 DSGKSTTALHQENNKIK----ELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
K+ T + Q K + + ++E+E K KL L E+ E + + A+
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR------LQAAEEHVEAVNAKCAS 1419
Query: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
Q L E+E + +++ + A ++ K L E + K E++A +K
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA-SQK 1478
Query: 726 IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
+ TE + S+ Q + ++EN+N L +EI +LT+++
Sbjct: 1479 EARSLGTELFKIKNAYEESLDQLETLKRENKN--LQQEISDLTEQIAE------------ 1524
Query: 786 NGRRISDPQVFSKEVQTE 803
G+RI + + K+V+ E
Sbjct: 1525 GGKRIHELEKIKKQVEQE 1542
Score = 85.9 bits (211), Expect = 2e-16
Identities = 144/696 (20%), Positives = 293/696 (42%), Gaps = 110/696 (15%)
Query: 63 QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
Q E+L R LE E++A++ + L++ + D LL QY K LQR
Sbjct: 1317 QIEELKRQ--------LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKA--ELQRA 1366
Query: 123 AFQAKSTPWQEDIYEKPMNELDKV--VEKHKESYRRILGQLLVAEK----------SRRQ 170
+A + E + E D + E+ +E+ +++ +L AE+ S +
Sbjct: 1367 LSKANT----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 171 TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTT 227
T L+ E +E+++ L+++ K++ + + EE E E K +
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 228 LKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQK 287
L EL K+K+ +D+ + L + +Q+I +LT ++A R+ E E
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT-------EQIAEGGKRIHELE-- 1533
Query: 288 ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA 347
+++K+++ + + + A L +E+ + ++Q +L + ++D R + +
Sbjct: 1534 --KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD------RKIAEK 1585
Query: 348 EEELQDIKEK-ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE 406
+EE+ +K I E + + AE+ + + + +L +ME Q N R+ E
Sbjct: 1586 DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN-RMAAE 1644
Query: 407 TLQS--------KDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMT 454
L++ KD ++ ++ + L++ +E N + E L+ LE+ +
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1704
Query: 455 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 514
K QEL R++ L + L T+ L+ D+++++ + E + EK KK
Sbjct: 1705 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKA 1764
Query: 515 EDKLQAASSQLQVEQNKVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 572
+ +L+ EQ+ + +K +E+T + L+ + D E++ LK
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL------------ALK 1812
Query: 573 AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV 632
+++ L +RV L+ ++S + K N ++ K L + ++KEL+ +
Sbjct: 1813 GGKKQIQKLEARVRELEGEVES---------EQKRNAEAVK---GLRKHERRVKELTYQT 1860
Query: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
E + + ++ + D L Y +R A E + E LAK++
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSY----KRQAEEAE---------EQSNTNLAKFR---- 1903
Query: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHE 728
+ HE L+E E ++ +V+ L+ K E
Sbjct: 1904 -KLQHE------LEEAEERADIAESQVNKLRVKSRE 1932
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 119 bits (297), Expect = 2e-26
Identities = 138/680 (20%), Positives = 302/680 (44%), Gaps = 91/680 (13%)
Query: 121 RDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
R K PW + ++ + L K E KE + ++ ++++E
Sbjct: 825 RSFMNVKHWPWMKLFFK--IKPLLKSAETEKEM------------ATMKEEFQKIKDELA 870
Query: 181 KHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAL 240
K + ++ +E + L +E L+ + E + + E+ ++ + T + K+K
Sbjct: 871 KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTE 930
Query: 241 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 300
DE++ + A+LT +++K+++ + K+ L L A+V++E+ K L T
Sbjct: 931 RAEDEEE-INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL----T 985
Query: 301 KFHQDQDTIMAKLTNEDSQNRQL-QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
+ D +AKLT E ++ QQ L L + D++ ++ K E+++ D++ +
Sbjct: 986 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045
Query: 360 KG-------EYGNAGIMAEVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRLERETL 408
+ E + +++ ++ ++D+E + DE+L K E + +L ++E E
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQA 1105
Query: 409 QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELE----- 463
+ ++++L RI LE+ +A S+ + + +L +E +++S+ LE
Sbjct: 1106 LGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE---LEEISERLEEAGGA 1162
Query: 464 -SLKVRI---KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ 519
S ++ + +E E + R + E TL+ + T TL D + E++ D LQ
Sbjct: 1163 TSAQIEMNKKREAEFQKMRRDLEEATLQHEAT-AATLRKKHADSVAELGEQI----DNLQ 1217
Query: 520 AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
+L+ E++++ + L + K+K ++E+ + + +D ++LK++EE+
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEK----MCRTLEDQLSELKSKEEEQQ 1273
Query: 580 DLLSRVNMLKNRLQ------SLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVE 633
L++ + + RLQ S + EK+ L ++L++ T +I+EL +++E
Sbjct: 1274 RLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFT-------QQIEELKRQLE 1326
Query: 634 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKT 693
++K A+ L + + + L +Y E++ L + L E+A+++
Sbjct: 1327 E---EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWR----- 1378
Query: 694 ETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQ 753
T +E +R +E E L++ + A +E + + K
Sbjct: 1379 -TKYETDAIQRTEELEEAKKKLAQRLQAAEEHV-----------------EAVNAKCASL 1420
Query: 754 ENRNRDLGREIENLTKELER 773
E + L E+E+L ++ER
Sbjct: 1421 EKTKQRLQNEVEDLMLDVER 1440
Score = 116 bits (290), Expect = 1e-25
Identities = 176/846 (20%), Positives = 361/846 (42%), Gaps = 144/846 (17%)
Query: 82 ELQAR-DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
ELQAR +E+ ++AE+ A E Q ++ +++ E +R +T Q ++ +K
Sbjct: 1116 ELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQIEMNKKRE 1174
Query: 141 NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
E K+ +E+ + K ++ EL E+ + +K LE+E
Sbjct: 1175 AEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQK-------LEKEK 1227
Query: 201 ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
+K ID + E + K EK TL+++L++LKS +EQQRL LT QR
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE----EEQQRLINDLTAQR 1283
Query: 258 QKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKELQTQTTKFH------ 303
++Q E +++ K AL +A Q+ E+ +LE+E++ + H
Sbjct: 1284 GRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSR 1343
Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSLRK-- 346
D D + + E +LQ+ L+ + ++ +ELEE + L +
Sbjct: 1344 HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403
Query: 347 --AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 404
AEE ++ + K + E + EVE+L +LD+E + ++++ R+ +K L
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---MLDVERTNAACAALDKKQRNFDKILA 1460
Query: 405 RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC---NLEKERMT-TK 456
+ ++ E+E K +L K+++A+ +S + +LK NL++E T+
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 457 QLSQ------ELESLKVRIKE--------LEAIESRLE----------------KTEFTL 486
Q+++ ELE +K ++++ LE E+ LE K+E
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 487 K-----EDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQAASSQLQVEQNKVTT 534
K E++ +LK + V+ + T+ +++ D K++ ++++++ N
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640
Query: 535 VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 594
+ + + + D + + + ++DLK +L E + N L + + L+ L+
Sbjct: 1641 MAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700
Query: 595 LEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLKLKLKDM-------- 642
E K + L D+ + LH +N + K+L ++ +++ +++D+
Sbjct: 1701 TERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE 1758
Query: 643 ----KAIED------DLMKTEDEYETLERRYANER----------DKAQFLS-----KEL 677
KAI D +L K +D LER N D+A+ L+ K++
Sbjct: 1759 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1818
Query: 678 EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
+ ++ + + + ++E K L++ E + L+ + + ++ I + +DL+
Sbjct: 1819 QKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI---LRLQDLVD 1875
Query: 738 HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFS 797
LQ +++ + E ++ + L ELE + +N R+ +V +
Sbjct: 1876 KLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHT 1935
Query: 798 KEVQTE 803
K + E
Sbjct: 1936 KVISEE 1941
Score = 112 bits (280), Expect = 2e-24
Identities = 122/547 (22%), Positives = 255/547 (46%), Gaps = 73/547 (13%)
Query: 287 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 346
K+ EKE+ T +F + +D +L +++ ++L++K+ L ++ ++L+ ++
Sbjct: 847 KSAETEKEMATMKEEFQKIKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQA 899
Query: 347 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 401
E L D +E+ + + A+++E+ +R D E + EL K+E++C +L K
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 959
Query: 402 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 447
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 448 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD-E 503
+K TK +L Q+++ L+ +++ + + LE+ + L+ DL KL ++M ++ E
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENE 1078
Query: 504 RKTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDV 553
++ + EKLKK E ++ QA QLQ + ++ E+L EE + S+
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA 1138
Query: 554 EEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGK 613
E++ +++E +++ +L EE G +++ M K R + + +D L+ Q
Sbjct: 1139 EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKMRRD-LEEATLQHEAT 1194
Query: 614 STTALHQENNKIKELSQEV---ERLKLKLK----DMKAIEDDLMKTEDEYETLERRYANE 666
+ T + + + EL +++ +R+K KL+ +MK DDL ET+ + N
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDL---ASNVETVSKAKGNL 1251
Query: 667 RDKAQFLSKELEHVK------MELAKYKLAEKTETSHEQWLFKR-LQEEEAKSGHLSR-- 717
+ L +L +K L A++ E F R L E+EA LSR
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 718 -----EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLT 768
+++ LK ++ E + ++ + H + D +L+++ +++ +L R +
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 769 KELERYR 775
E+ ++R
Sbjct: 1372 TEVAQWR 1378
Score = 102 bits (254), Expect = 2e-21
Identities = 160/738 (21%), Positives = 323/738 (43%), Gaps = 105/738 (14%)
Query: 82 ELQARDEVIGILKAEKMDLALLEAQYGFVTP-KKVLE-ALQRDAFQAKSTPWQEDIYEKP 139
+LQ + E G+ AE+ L++ + K+V E A + A+ T + + E
Sbjct: 894 QLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL-EDE 952
Query: 140 MNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQE 199
+EL K ++ + + ++ EK + T E + + E M DE I L +E
Sbjct: 953 CSELKKDIDDLELTLAKV-------EKEKHAT----ENKVKNLTEEMAGLDETIAKLTKE 1001
Query: 200 CERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQK 259
KK + + + + Q +E +V TL + KL+ VD+ L L +++
Sbjct: 1002 ----KKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ----QVDD---LEGSLEQEKKL 1050
Query: 260 IQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQ 319
+L ++ L LA+ + + E + +L+++L+ + + + +K+ +E +
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI----SNLQSKIEDEQAL 1106
Query: 320 NRQLQQKLAALSRQIDELEETNRSLR----KAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
QLQ+K+ L +I+ELEE + R KAE++ D+ E+EE+
Sbjct: 1107 GIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR--------------ELEEI 1152
Query: 376 RKRVLDMEGKDEELIKM----EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLE 431
+R+ + G I+M E + + + + LE TLQ + + K K ++ +L
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK--KHADSVAELG 1210
Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT 491
+ + ++ +K LEKE+ ++ E++ L ++ + + LEK TL++ L+
Sbjct: 1211 EQIDNLQR----VKQKLEKEK---SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS 1263
Query: 492 KLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKT 551
+L K+ E+ ++ + L A +LQ E + + ++ K AL S+
Sbjct: 1264 EL-----------KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE-----KEALVSQL 1307
Query: 552 DVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EAIEKDFLKNKLNQ 609
++ + T++ ++LK +L+ E + N L + ++ L + E+ K +L +
Sbjct: 1308 SRGKQAF--TQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQR 1365
Query: 610 DSGKSTTALHQENNKIK----ELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
K+ T + Q K + + ++E+E K KL L E+ E + + A+
Sbjct: 1366 ALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQR------LQAAEEHVEAVNAKCAS 1419
Query: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
Q L E+E + +++ + A ++ K L E + K E++A +K
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA-SQK 1478
Query: 726 IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
+ TE + S+ Q + ++EN+N L +EI +LT+++
Sbjct: 1479 EARSLGTELFKIKNAYEESLDQLETLKRENKN--LQQEISDLTEQIAE------------ 1524
Query: 786 NGRRISDPQVFSKEVQTE 803
G+RI + + K+V+ E
Sbjct: 1525 GGKRIHELEKIKKQVEQE 1542
Score = 85.9 bits (211), Expect = 2e-16
Identities = 144/696 (20%), Positives = 293/696 (42%), Gaps = 110/696 (15%)
Query: 63 QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
Q E+L R LE E++A++ + L++ + D LL QY K LQR
Sbjct: 1317 QIEELKRQ--------LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKA--ELQRA 1366
Query: 123 AFQAKSTPWQEDIYEKPMNELDKV--VEKHKESYRRILGQLLVAEK----------SRRQ 170
+A + E + E D + E+ +E+ +++ +L AE+ S +
Sbjct: 1367 LSKANT----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 171 TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTT 227
T L+ E +E+++ L+++ K++ + + EE E E K +
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS 1482
Query: 228 LKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQK 287
L EL K+K+ +D+ + L + +Q+I +LT ++A R+ E E
Sbjct: 1483 LGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT-------EQIAEGGKRIHELE-- 1533
Query: 288 ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA 347
+++K+++ + + + A L +E+ + ++Q +L + ++D R + +
Sbjct: 1534 --KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD------RKIAEK 1585
Query: 348 EEELQDIKEK-ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE 406
+EE+ +K I E + + AE+ + + + +L +ME Q N R+ E
Sbjct: 1586 DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN-RMAAE 1644
Query: 407 TLQS--------KDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMT 454
L++ KD ++ ++ + L++ +E N + E L+ LE+ +
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERS 1704
Query: 455 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 514
K QEL R++ L + L T+ L+ D+++++ + E + EK KK
Sbjct: 1705 RKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKA 1764
Query: 515 EDKLQAASSQLQVEQNKVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 572
+ +L+ EQ+ + +K +E+T + L+ + D E++ LK
Sbjct: 1765 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL------------ALK 1812
Query: 573 AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV 632
+++ L +RV L+ ++S + K N ++ K L + ++KEL+ +
Sbjct: 1813 GGKKQIQKLEARVRELEGEVES---------EQKRNAEAVK---GLRKHERRVKELTYQT 1860
Query: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
E + + ++ + D L Y +R A E + E LAK++
Sbjct: 1861 EEDRKNILRLQDLVDKLQAKVKSY----KRQAEEAE---------EQSNTNLAKFR---- 1903
Query: 693 TETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHE 728
+ HE L+E E ++ +V+ L+ K E
Sbjct: 1904 -KLQHE------LEEAEERADIAESQVNKLRVKSRE 1932
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 118 bits (295), Expect = 4e-26
Identities = 126/593 (21%), Positives = 270/593 (45%), Gaps = 95/593 (16%)
Query: 217 KEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL 276
K E EK + +KEE K K +++ L ++ Q+ +L + LA
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 277 AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
AE R + + +LE +++ + T+ +D++ I A+LT ++ R+L+ + + L + ID+
Sbjct: 905 AEERCDQLIKTKIQLEAKIK-EVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDD 960
Query: 337 LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 396
LE T L K E+E + K+ + +M G DE + K+ ++
Sbjct: 961 LELT---LAKVEKEKHATENKV-----------------KNLTEEMAGLDETIAKLTKEK 1000
Query: 397 RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK 456
+ L + ++TL D ++E +K++ A KLE Q+ L+ +LE+E K
Sbjct: 1001 KALQEA-HQQTLD--DLQMEEDKVNTLTKAKTKLE-------QQVDDLEGSLEQE----K 1046
Query: 457 QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTED 516
+L +LE K + L+ DL + T+ ++++ ++EKLKK E
Sbjct: 1047 KLCMDLERAKRK-----------------LEGDLKLAQESTMDTENDKQQLNEKLKKKEF 1089
Query: 517 KL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDD 566
++ QA + QLQ + ++ E+L EE + S+ E++ +++E ++
Sbjct: 1090 EMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 567 LKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS---------GKSTTA 617
+ +L EE G +++ M K R + + +D ++ L ++ S
Sbjct: 1150 ISERL---EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAE 1206
Query: 618 LHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFL 673
L ++ + ++ + Q++E+ LK+++ D+ + + + K + +E + R ++ + +
Sbjct: 1207 LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTK 1266
Query: 674 SKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR-------EVDALKEKI 726
+E + + EL+ K TE+ ++L E++A LSR +++ LK ++
Sbjct: 1267 EEEQQRLINELSAQKARLHTESGE---FSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL 1323
Query: 727 HEYMATEDLICH----LQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 775
E + + H + D +L+++ +++ +L R + E+ ++R
Sbjct: 1324 EEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376
Score = 114 bits (284), Expect = 7e-25
Identities = 169/846 (19%), Positives = 356/846 (42%), Gaps = 144/846 (17%)
Query: 82 ELQAR-DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
ELQAR +E+ ++AE+ A E Q ++ +++ E +R +T Q ++ +K
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQIEMNKKRE 1172
Query: 141 NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
E K+ +ES + K ++ EL E+ + +K LE+E
Sbjct: 1173 AEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQK-------LEKEK 1225
Query: 201 ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
LK I+ + E + K EK TL+++L+++K+ +EQQRL +L+ Q+
Sbjct: 1226 SELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKE----EEQQRLINELSAQK 1281
Query: 258 QKIQ-ELTTNAKETHTKLALA-------EARVQEEEQKATRLEKELQTQTTKFH------ 303
++ E +++ K A+ +A Q+ E+ +LE+E + ++T H
Sbjct: 1282 ARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSAR 1341
Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSLRK-- 346
D D + + E +LQ+ ++ + ++ +ELEE + L +
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 347 --AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 404
AEE ++ + K + E + EVE+L ++D+E + I ++++ R+ +K L
Sbjct: 1402 QDAEEHVEAVNSKCASLEKTKQRLQNEVEDL---MIDVERSNAACIALDKKQRNFDKVLA 1458
Query: 405 RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKC---NLEKE------ 451
+ ++ + E+E K +L K+++A+ +S +LK NL++E
Sbjct: 1459 EWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTE 1518
Query: 452 ------------RMTTKQLSQELESLKVRIKELEA------------------IESRLEK 481
KQL E L+ ++E EA ++S +++
Sbjct: 1519 QIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDR 1578
Query: 482 TEFTLKEDLTKLKTLTVMFVDE-RKTMSEKLKKTED------KLQAASSQLQVEQNKVTT 534
E+L +LK + V+ + T+ +++ D K++ ++++++ N
Sbjct: 1579 KIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANR 1638
Query: 535 VTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQS 594
+ + + D + + + +DDLK +L E + N + + V L+ L+
Sbjct: 1639 QAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER 1698
Query: 595 LEAIEKDFLKNKLNQDSGKSTTALHQENNKI----KELSQEVERLKLKLKDM-------- 642
E K + L D+ + LH +N + K+L ++ +++ +++D+
Sbjct: 1699 TERGRKMAEQELL--DASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE 1756
Query: 643 ----KAIED------DLMKTEDEYETLERRYANER----------DKAQFLS-----KEL 677
KAI D +L K +D LER N D+A+ L+ K++
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQI 1816
Query: 678 EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
+ ++ + + + ++E H K L++ E + L+ + + ++ I + +DL+
Sbjct: 1817 QKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNI---LRLQDLVD 1873
Query: 738 HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFS 797
LQ +++ + E ++ + L ELE + + +N R+ +V +
Sbjct: 1874 KLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHT 1933
Query: 798 KEVQTE 803
K + E
Sbjct: 1934 KVISEE 1939
Score = 105 bits (261), Expect = 3e-22
Identities = 153/761 (20%), Positives = 307/761 (40%), Gaps = 125/761 (16%)
Query: 116 LEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQ----- 170
++ L + A K ++ +EK EL K K KE +++ L+ EK+ Q
Sbjct: 840 IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMV--TLMQEKNDLQLQVQA 897
Query: 171 -----------------TILELEEEKRKHKEYMEKSDEFIC-------LLEQECERLKKL 206
T ++LE + ++ E E +E LE EC LKK
Sbjct: 898 EADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 957
Query: 207 IDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTA-------QLTLQ 256
ID + + E+EK E +V L EE+ L + E++ L L ++
Sbjct: 958 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQME 1017
Query: 257 RQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEK----------------------- 293
K+ LT + ++ E +++E++ LE+
Sbjct: 1018 EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDK 1077
Query: 294 -ELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 352
+L + K + + K+ +E + QLQ+K+ L +I+EL EEE++
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEEL----------EEEIE 1127
Query: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKM----EEQCRDLNKRLERETL 408
+ +K E + + E+EE+ +R+ + G I+M E + + + + LE TL
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTL 1187
Query: 409 QSKDFKLEV-EKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Q + + +K + + L + D+ + KQ+ LEKE+ +L E+ L
Sbjct: 1188 QHEATAAALRKKHADSVAELGEQIDSLQRVKQK-------LEKEK---SELKMEINDLAS 1237
Query: 468 RIKELEAIESRLEKTEFTLKEDLTKLKT--------LTVMFVDERK--TMSEKLKKTEDK 517
++ + ++ EK TL++ L+++KT + + + + T S + + D+
Sbjct: 1238 NMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE 1297
Query: 518 LQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 577
A SQL + T E+L + + K+K+ + + S + D L+ + + E+E
Sbjct: 1298 KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEA 1357
Query: 578 GNDL---LSRVN------MLKNRLQSLEAIEK-DFLKNKLNQDSGKSTTALHQENNKIKE 627
+L +S+ N K +++ E+ + K KL Q + + N+K
Sbjct: 1358 KAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS 1417
Query: 628 LSQEVERLKLKLKDMK-----------AIEDDLMKTEDEYETLERRYANERDKAQFLSKE 676
L + +RL+ +++D+ A++ + +++Y + + + KE
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE 1477
Query: 677 LEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLI 736
+ EL K K A + H + L + + + + L+ ++ + IHE + +
Sbjct: 1478 SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQL 1537
Query: 737 CH----LQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 773
H LQ + L +E + + E+ + E++R
Sbjct: 1538 DHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDR 1578
Score = 85.1 bits (209), Expect = 3e-16
Identities = 142/686 (20%), Positives = 294/686 (42%), Gaps = 91/686 (13%)
Query: 63 QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
Q E+L R LE E +A+ + L++ + D LL QY K LQR
Sbjct: 1315 QIEELKRQ--------LEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA--ELQRG 1364
Query: 123 AFQAKSTPWQEDIYEKPMNELDKV--VEKHKESYRRILGQLLVAEK----------SRRQ 170
+A S E + E D + E+ +E+ +++ +L AE+ S +
Sbjct: 1365 MSKANS----EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEK 1420
Query: 171 TILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTT 227
T L+ E +E+S+ L+++ K++ + + EE + E E K +
Sbjct: 1421 TKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRS 1480
Query: 228 LKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQK 287
L EL K+K+ +D + L + +Q+I +LT ++A + E E
Sbjct: 1481 LSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTE-------QIAEGGKHIHELE-- 1531
Query: 288 ATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA 347
+++K+L + ++ + A L +E+ + ++Q +L + +ID R + +
Sbjct: 1532 --KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEID------RKIAEK 1583
Query: 348 EEELQDIKEK-ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE 406
+EEL +K + E + + AE+ + + + +L +ME Q N++ E
Sbjct: 1584 DEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAA-E 1642
Query: 407 TLQS--------KDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMT 454
L++ KD +L ++ + L++ +E N + E L+ +LE+
Sbjct: 1643 ALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERG 1702
Query: 455 TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT 514
K QEL R++ L + L T+ L+ D+++++ V E + EK KK
Sbjct: 1703 RKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKA 1762
Query: 515 EDKLQAASSQLQVEQNKVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK 572
+ +L+ EQ+ + +K +E+T + L+ + D E++ LK
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQL------------ALK 1810
Query: 573 AEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV 632
+++ L +RV L++ ++S + K N ++ K L + ++KEL+ +
Sbjct: 1811 GGKKQIQKLEARVRELESEVES---------EQKHNVEAVK---GLRKHERRVKELTYQT 1858
Query: 633 ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEK 692
E + K++ ++D + K + + + +R+ +++ + ++ EL + K E+
Sbjct: 1859 EEDR---KNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAK--ER 1913
Query: 693 TETSHEQWLFKRLQEEEAKSGHLSRE 718
+ + Q R++ E + +S E
Sbjct: 1914 ADIAESQVNKLRVKSREVHTKVISEE 1939
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 117 bits (293), Expect = 6e-26
Identities = 156/737 (21%), Positives = 335/737 (45%), Gaps = 101/737 (13%)
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
EK M EL + K+ + +++ A R I ++ E+ K + + +
Sbjct: 1323 EKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREV 1382
Query: 197 EQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLT-- 254
+ +RL++ + +++ +++ +++ E+R+ L+ + + + + + QRLTA+L
Sbjct: 1383 DFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDT 1442
Query: 255 ---LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA 311
L+ Q+++ K+ L++A EE + +L++E K +++D ++A
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQA---HEEAQREKLQRE------KLQREKDMLLA 1493
Query: 312 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAE 371
+ + Q + +A ++++ L E ELQDI + SK E A + +
Sbjct: 1494 EAFSLKQQLEEKDMDIAGFTQKVVSL----------EAELQDISSQESKDEASLAKVKKQ 1543
Query: 372 VEELRKRVLDMEGKDEE---LIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 428
+ +L +V D E + +E I+M EQ + L +E E ++ K E+E E
Sbjct: 1544 LRDLEAKVKDQEEELDEQAGTIQMLEQAK-LRLEMEMERMRQTHSK-EMESRD------E 1595
Query: 429 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKEL-EAIESRLEKTEFTLK 487
++E+A +++ ++ LE+E +++ +E L+ ++ L + + R ++E L+
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLR 1655
Query: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVT----------- 536
+DL + K L D + + K + A + Q+E+++ T
Sbjct: 1656 KDLKRTKAL---LADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVE 1712
Query: 537 -EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL-------------- 581
E L + K+KT +EE++ + +E+++++N+L+ ++E N+L
Sbjct: 1713 IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRD 1772
Query: 582 LSRVNMLKNRLQSLEAIEKDFLKNKLN---------QDSGKSTTALHQENNKIKELSQEV 632
L+++N L+ +L+ EK L+ KL + S + + ++ KI+EL +
Sbjct: 1773 LAQINDLQAQLEEANK-EKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRL 1831
Query: 633 ERLKLKLKDMKAIEDDLMKTEDEY-ETLERRYA---NERDKAQFLSKELEHVKMELAKY- 687
E + ++K ++++ L + ++ E ++R A E+++ + L ++L K E+ +
Sbjct: 1832 EFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELA 1891
Query: 688 -KLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMA----------TEDLI 736
K AE + HE L L+ EA + L ++ ++I + A EDLI
Sbjct: 1892 RKEAEASRKKHE--LEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLI 1949
Query: 737 CHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL-----NGRRIS 791
LQ + QK+ N+ E + D+ E+E+ ++ + SK+ PS + S
Sbjct: 1950 NSLQDMVTKYQKRKNKLEG-DSDVDSELEDRVDGVKSW--LSKNKGPSKAASDDGSLKSS 2006
Query: 792 DPQVFSKEVQTEAVDNE 808
P + K + + D+E
Sbjct: 2007 SPTSYWKSLAPDRSDDE 2023
Score = 95.9 bits (237), Expect = 2e-19
Identities = 119/647 (18%), Positives = 277/647 (42%), Gaps = 113/647 (17%)
Query: 210 EIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKE 269
E++ EE+ + K++ + L+ +L K + E+ L +I ELT+ +
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEK-------ERNELRLNSDRLESRISELTSELTD 1300
Query: 270 THTKLALAEARVQEEEQKATRLEKELQTQTTKFH--------QDQDTIMAKLTNEDSQNR 321
A + E + R EKE++ T++ + + + A+L N
Sbjct: 1301 ERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEING 1360
Query: 322 QLQQKLAA------LSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 375
++ A R + E++ T + L++ E+ +++++ + +L
Sbjct: 1361 EVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKR-------------QL 1407
Query: 376 RKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFN 435
+R+ D++ EE + + L K+ +R T + +D KL +E R LEK + F+
Sbjct: 1408 ERRLGDLQADSEE---SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFD 1464
Query: 436 KSKQ-------------------------ECYSLKCNLEKERMTTKQLSQELESLKVRIK 470
E +SLK LE++ M +Q++ SL+ ++
Sbjct: 1465 SELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQ 1524
Query: 471 ELEAIESRLEKTEFTLKEDLTKLKTL-------------TVMFVDE------------RK 505
++ + ES+ E + +K+ L L+ T+ +++ R+
Sbjct: 1525 DISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQ 1584
Query: 506 TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKE-- 563
T S++++ +++++ A Q + ++ E+ E+ ++ L+ K ++E K+ +++ +
Sbjct: 1585 THSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVN 1644
Query: 564 -RD-DLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDF--LKNKLNQDSGKSTTALH 619
RD + + +L+ + ++ LL+ ++ + L++ +++ LKN+L + A+
Sbjct: 1645 RRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVK 1704
Query: 620 QENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEH 679
K + E+E L L++ DD+ K + E R E+++ Q +E +
Sbjct: 1705 AR----KAMEVEIEDLHLQI-------DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE 1753
Query: 680 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHL 739
EL K A + S + ++ + +A+ ++E L+EK+ + + +
Sbjct: 1754 DMNELMKKHKAAVAQASRD---LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFL--- 1807
Query: 740 QGDHSVLQKKL-NQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 785
+ S++ K L ++QE + R+L +E +++R + L+ ++
Sbjct: 1808 --EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENM 1852
Score = 91.3 bits (225), Expect = 5e-18
Identities = 127/611 (20%), Positives = 256/611 (41%), Gaps = 103/611 (16%)
Query: 20 TKGHSFQGPKNMKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSIL 79
TK H +G + H + K +S++ +A++ Q E L R+ + L
Sbjct: 1442 TKLH-LEGQQVRNHELEKKQRRFDSELSQAHEEAQREKL----QREKLQREKDMLLAEAF 1496
Query: 80 EGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEA-LQRDAFQAKSTPWQEDIYEK 138
+ Q L+ + MD+A GF LEA LQ + Q +K
Sbjct: 1497 SLKQQ--------LEEKDMDIA------GFTQKVVSLEAELQDISSQESKDEASLAKVKK 1542
Query: 139 PMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ 198
+ +L+ V+ +E G + + E+++ + +E+E ++ H + ME DE + Q
Sbjct: 1543 QLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQ 1602
Query: 199 ECERLKKLIDQEIKSQEEKE---------QEKEKRVTTLKEELTKLKSFALMVVDEQQRL 249
C+ KKL E++ +EE E +E E ++ TL +++ + + + + +
Sbjct: 1603 SCQ--KKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKR 1660
Query: 250 TAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEE---------QKATRLEKE------ 294
T L Q + + N+ + ++A + +++E E +KA +E E
Sbjct: 1661 TKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720
Query: 295 ---------LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQK----LAALSRQIDELEETN 341
L+ Q ++ ++++ I +L + +L +K +A SR + ++ +
Sbjct: 1721 DDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQ 1780
Query: 342 RSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNK 401
L +A +E Q+++EK+ + ++VE L + ++D + + E + R+L
Sbjct: 1781 AQLEEANKEKQELQEKLQ-------ALQSQVEFLEQSMVD----KSLVSRQEAKIRELET 1829
Query: 402 RLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE 461
RLE E Q K +E L+ R+ E +E + Q + N EKE+ K+L ++
Sbjct: 1830 RLEFERTQVK----RLESLASRLK--ENMEKLTEERDQRIAAE--NREKEQ--NKRLQRQ 1879
Query: 462 LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 521
L K + EL E+ + + L+ DL L+ + K K+ D A
Sbjct: 1880 LRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKL---AFKRIGDLQAAI 1936
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 581
+++ ++N+ D+ + + + KNKL+ + + ++L
Sbjct: 1937 EDEMESDENE--------------------DLINSLQDMVTKYQKRKNKLEGDSDVDSEL 1976
Query: 582 LSRVNMLKNRL 592
RV+ +K+ L
Sbjct: 1977 EDRVDGVKSWL 1987
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 116 bits (290), Expect = 1e-25
Identities = 138/665 (20%), Positives = 292/665 (43%), Gaps = 94/665 (14%)
Query: 188 KSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQ 247
++++ + ++++ ER K +E+ E + +E E+++ +L +E L+ L V E
Sbjct: 848 EAEKEMATMKEDFERTK----EELARSEARRKELEEKMVSLLQEKNDLQ---LQVQSE-- 898
Query: 248 RLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRL---EKELQTQTTKFHQ 304
T L ++ + L + K+ R++EEE+ + L ++ L+ + + +
Sbjct: 899 --TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR 956
Query: 305 DQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK----ISK 360
D D + LT + + + K+ LS ++ LEE L K ++ LQ+ ++ +
Sbjct: 957 DIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQV 1016
Query: 361 GEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKL 420
E G++ +L ++ D+EG E+ K+ ++LE + S++ +++E
Sbjct: 1017 EEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEND 1076
Query: 421 SKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE------- 473
++I E+ K + E L+ ++ E++ + Q ++++ L+ RI+ELE
Sbjct: 1077 KQQI------EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH 1130
Query: 474 AIESRLEKTEFTLKEDLTKL------------------KTLTVMFVDERKTMSE------ 509
+ +++EK L +L ++ K F R+ + E
Sbjct: 1131 TLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
Query: 510 ---------------KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 554
+L + D LQ +L+ E++++ + + + KSK+++E
Sbjct: 1191 ATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250
Query: 555 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL--EAIEKDFLKNKLNQDSG 612
+V +D +++KA++E+ L+ +NM K RLQ+ E + K L
Sbjct: 1251 RTCRTV----EDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLT 1306
Query: 613 KSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQF 672
KS AL Q+ ++EL +++E + K A+ L + + + L +Y E++
Sbjct: 1307 KSKQALTQQ---LEELKRQMEE---ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE 1360
Query: 673 LSKELEHVKMELAKYKLAEKTET--------SHEQWLFKRLQEEEAKSGHLSREVDAL-K 723
L + L E+A+++ +T+ ++ L +RLQE E + + + +L K
Sbjct: 1361 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEK 1420
Query: 724 EKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERYRHFSKS 780
K EDL+ L+ H+ +Q N ++ L ++++ ELE + S+S
Sbjct: 1421 TKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRS 1480
Query: 781 LRPSL 785
L L
Sbjct: 1481 LSTEL 1485
Score = 102 bits (255), Expect = 2e-21
Identities = 136/668 (20%), Positives = 293/668 (43%), Gaps = 76/668 (11%)
Query: 31 MKHRQQDKDSPSESDVILPCPKAEKPHSGNGHQAEDLSRDDLLFLLSILEGELQARDEVI 90
+ HR ++K+S +I K+++ + Q E+L R +E E +A++ +
Sbjct: 1291 LSHRVEEKES-----LISQLTKSKQALT---QQLEELKRQ--------MEEETKAKNAMA 1334
Query: 91 GILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKS------TPWQEDIY------EK 138
L++ + D LL QY K LQR +A S T ++ D E+
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKA--ELQRALSKANSEVAQWRTKYETDAIQRTEELEE 1392
Query: 139 PMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQ 198
+L + +++ +E+ + EK++++ E+E+ R +E+S L++
Sbjct: 1393 AKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRD----LERSHTACATLDK 1448
Query: 199 ECERLKKLIDQEIKSQEEKEQEKE---KRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
+ K++ + + +E + E E K +L EL K+++ VVD+ + L +
Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKN 1508
Query: 256 QRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTN 315
+++I +LT ET L AE + EQ+ + L+ L + + L +
Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVAL-----------EEVEGSLEH 1557
Query: 316 EDSQNRQLQQKLAALSRQID--------ELEETNRSLRKAEEELQDIKEKISKGEYGNAG 367
E+S+ ++Q +L+ + ++D E+E+ R+ ++A E LQ + + +
Sbjct: 1558 EESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR 1617
Query: 368 IMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMA 426
+ ++E +L + + + + ++ + ++ R + +L+ L D E L +++
Sbjct: 1618 LKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI 1677
Query: 427 LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTL 486
+E+ + +E +K LE+ T + QEL R++ L + + L T+ L
Sbjct: 1678 VERRNGLLLEELEE---MKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKL 1734
Query: 487 KEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTV--TEKLIEETK 544
+ D+ + + + E + EK KK + +L+ EQ+ + +K +E+T
Sbjct: 1735 EADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1794
Query: 545 RALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK 604
+ L+ + D E++ LK +++ L +RV L+N L + + LK
Sbjct: 1795 KDLQHRLDEAEQL------------ALKGGKKQIQKLENRVRELENELDVEQKRGAEALK 1842
Query: 605 --NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERR 662
+K + + T +++ I L V++L+ K+K K ++ + + + RR
Sbjct: 1843 GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRR 1902
Query: 663 YANERDKA 670
+E ++A
Sbjct: 1903 VQHELEEA 1910
Score = 102 bits (254), Expect = 2e-21
Identities = 162/772 (20%), Positives = 346/772 (44%), Gaps = 100/772 (12%)
Query: 70 DDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKST 129
DDL L+ +E E A + + L E + LE +T +K ++LQ +A Q
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEE---MTALEENISKLTKEK--KSLQ-EAHQQTLD 1012
Query: 130 PWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKS 189
Q + E +N L K+ K ++ + G L +K R +LE KRK + ++ S
Sbjct: 1013 DLQ--VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRA----DLERAKRKLEGDLKMS 1066
Query: 190 DEFICLLEQECERL-KKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQR 248
E I LE + +++ +KL +E + + + + +++V +L+ + K+K + + ++
Sbjct: 1067 QESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQ-KKIKELQARIEELEEE 1125
Query: 249 LTAQLTLQRQKIQELTTNAKETHTKLA--LAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
+ A+ TL R KI++ ++ +++ L EA Q ++E + Q + ++
Sbjct: 1126 IEAEHTL-RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ----DIKEKISKGE 362
T+ + T + +Q +A L QID L+ + L K + EL+ D+ I
Sbjct: 1185 ATLQHEATAATLRKKQ-ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 363 YGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSK 422
+ I + + +++ KDE+ ++ DLN + R Q+ + VE+
Sbjct: 1244 KSKSNIERTCRTVEDQFSEIKAKDEQQTQL---IHDLNMQKARLQTQNGELSHRVEEKES 1300
Query: 423 RIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELES-------LKVRIKELEAI 475
I L K + A + +E LK +E+E ++ L+S L+ + +E +
Sbjct: 1301 LISQLTKSKQALTQQLEE---LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357
Query: 476 ESRLE----KTEFTLKEDLTKLKTLTVMFVDE----RKTMSEKLKKTEDKLQAASSQ--- 524
++ L+ K + + TK +T + +E +K ++++L++ E+ + A+S+
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS 1417
Query: 525 LQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTK-------ERDDLKNKLKAEEEK 577
L+ + ++ E L+ + +R+ + +++K + K + D+ + +L+A +++
Sbjct: 1418 LEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477
Query: 578 GNDLLSRVNMLKN-------RLQSLEAIEKDFLK------------NKLNQDSGKSTTAL 618
L + + ++N +L++L K+ + K Q++ K+ +
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLV 1537
Query: 619 HQENNKIKELSQEVE-----------RLKLKLKDMKA-IEDDLMKTEDEYETLERRYANE 666
QE + ++ +EVE R++L+L +K+ ++ +++ ++E E L+R N
Sbjct: 1538 EQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKR---NS 1594
Query: 667 RDKAQFLSKELE-HVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
+ A+ L L+ ++ +L +K E L E E + GH +R++ ++
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEGD--------LNEMEIQLGHSNRQMAETQKH 1646
Query: 726 IHEYMA-TEDLICHLQG---DHSVLQKKLNQQENRNRDLGREIENLTKELER 773
+ +D HL + L+++L E RN L E+E + LE+
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQ 1698
Score = 99.8 bits (247), Expect = 1e-20
Identities = 106/543 (19%), Positives = 253/543 (46%), Gaps = 65/543 (11%)
Query: 287 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 346
K+ EKE+ T F + ++ +L +++ ++L++K+ +L ++ ++L+ ++
Sbjct: 845 KSAEAEKEMATMKEDFERTKE----ELARSEARRKELEEKMVSLLQEKNDLQ---LQVQS 897
Query: 347 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNKR 402
E L D +E+ + A+V+EL +R+ + E + EL+ +E++C L +
Sbjct: 898 ETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD 957
Query: 403 LERETLQSKDFKLE-------VEKLSKRIMALEKLEDAFNKSK---QECYSLKCN---LE 449
++ L + E V+ LS+ + ALE+ K K QE + + +E
Sbjct: 958 IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 450 KERMT-----TKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
++++ +L Q+ + L+ +++ + + + LE+ + L+ DL + + +++
Sbjct: 1018 EDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK 1077
Query: 505 KTMSEKLKKTE----------DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 554
+ + EKLKK E D Q S Q Q + ++ E+L EE + + +E
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137
Query: 555 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKS 614
++ + +E +++ +L EE +++ M K R + + +D + L ++ +
Sbjct: 1138 KQRSDLARELEEISERL---EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1194
Query: 615 TTALHQENN------------KIKE-LSQEVERLKLKLKDMKAIEDDLMKTEDEYE---- 657
T Q ++ ++K+ L +E LK+++ DM + + L K++ E
Sbjct: 1195 TLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCR 1254
Query: 658 TLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGH-LS 716
T+E +++ + K + ++ + + M+ A+ + + E SH + L + KS L+
Sbjct: 1255 TVEDQFSEIKAKDEQQTQLIHDLNMQKARLQ-TQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 717 REVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLTKELE 772
++++ LK ++ E ++ + H + D +L+++ +++ +L R + E+
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVA 1373
Query: 773 RYR 775
++R
Sbjct: 1374 QWR 1376
Score = 78.6 bits (192), Expect = 3e-14
Identities = 103/474 (21%), Positives = 206/474 (43%), Gaps = 76/474 (16%)
Query: 335 DELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK--- 391
++ E T L ++E ++++EK+ + +V+ + ++D E + E LIK
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917
Query: 392 -MEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK-LEDAFNKSKQECYSLKCNLE 449
+E + ++L +RLE E E+++ ++A ++ LED +C SLK +++
Sbjct: 918 LLEAKVKELTERLEEE-----------EEMNSELVAKKRNLED-------KCSSLKRDID 959
Query: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE 509
+T ++ +E + + ++K L + LE E+++KL E+K++ E
Sbjct: 960 DLELTLTKVEKEKHATENKVKNLSEEMTALE-------ENISKL-------TKEKKSLQE 1005
Query: 510 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 569
++T D LQVE++KV LI+ + + D+E + K R DL+
Sbjct: 1006 AHQQTLD-------DLQVEEDKVNG----LIKINAKLEQQTDDLEGSLEQEKKLRADLER 1054
Query: 570 -KLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL 628
K K E + LK +S+ +E D K ++ + K L Q KI +
Sbjct: 1055 AKRKLEGD-----------LKMSQESIMDLEND--KQQIEEKLKKKEFELSQLQAKIDDE 1101
Query: 629 SQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMEL---- 684
+ + K+K+++A ++L + + TL + +R L++ELE + L
Sbjct: 1102 QVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSD---LARELEEISERLEEAS 1158
Query: 685 ----AKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQ 740
A+ ++ +K E ++ R EEA H + K++ + I +LQ
Sbjct: 1159 GATSAQIEMNKKREAEFQKM---RRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 741 GDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQ 794
L+K+ ++ + D+ IE L+K +++ + + D Q
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Score = 68.9 bits (167), Expect = 3e-11
Identities = 81/350 (23%), Positives = 155/350 (44%), Gaps = 68/350 (19%)
Query: 522 SSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGND- 580
S++ + E + E+ EE R+ + ++EEKM S+ +E++DL+ ++++E E D
Sbjct: 846 SAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDA 905
Query: 581 -------------LLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS---------------- 611
L ++V L RL+ E + + + K N +
Sbjct: 906 EERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTL 965
Query: 612 GKSTTALHQENNKIKELSQEV----ERLKLKLKDMKAIE-------DDLMKTEDEYETLE 660
K H NK+K LS+E+ E + K+ K+++ DDL ED+ L
Sbjct: 966 TKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLI 1025
Query: 661 RRYANERDKAQFLSKELEHVK-----MELAKYKLAEKTETSHE---------QWLFKRLQ 706
+ A + L LE K +E AK KL + S E Q + ++L+
Sbjct: 1026 KINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLK 1085
Query: 707 EEEAKSGHLSREVD-------ALKEKIHEYMA-TEDLICHLQGDHSVLQKKLNQQENRNR 758
++E + L ++D ++KI E A E+L ++ +H+ L+ K+ +Q +
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT-LRAKIEKQRS--- 1141
Query: 759 DLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 808
DL RE+E +++ LE + S + +N +R ++ Q ++++ + +E
Sbjct: 1142 DLARELEEISERLEE-ASGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 116 bits (290), Expect = 1e-25
Identities = 139/652 (21%), Positives = 275/652 (42%), Gaps = 91/652 (13%)
Query: 201 ERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKI 260
E +K D+ KS+ ++++ +EK VT LKE+ L V E L ++
Sbjct: 857 EEFQKTKDELAKSEAKRKELEEKMVTLLKEK----NDLQLQVQSEADSLADA----EERC 908
Query: 261 QELTTNAKETHTKLALAEARVQEEEQ---KATRLEKELQTQTTKFHQDQDTIMAKLTNED 317
++L N + K+ R +EEE+ + T +++L+ + ++ +D D + L +
Sbjct: 909 EQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 968
Query: 318 SQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI---SKGEYGNAGIMAEVE- 373
+ + K+ L+ ++ L+ET L K ++ LQ+ ++ + E I+ + +
Sbjct: 969 KEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKT 1028
Query: 374 ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA 433
+L ++V D+EG E+ K+ ++LE D KL E ++L++
Sbjct: 1029 KLEQQVDDLEGSLEQEKKLRMDLERAKRKLE------GDLKLAQESTMDMENDKQQLDEK 1082
Query: 434 FNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI------------------------ 469
K + E +L +E E+ QL ++++ L+ RI
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142
Query: 470 -KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE------------------- 509
+ELE I RLE+ + K F R+ + E
Sbjct: 1143 SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADS 1202
Query: 510 --KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDL 567
+L + D LQ +L+ E++++ T+ L + K+K ++E+ S+ + +L
Sbjct: 1203 MAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL 1262
Query: 568 KNKLKAEEEKGNDLLSRVNMLKNRL--QSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI 625
K K + ++ NDL ++ L+ S + EKD L ++L++ ST +I
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAST-------QQI 1315
Query: 626 KELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELA 685
+EL ++E + K A+ L + + + L +Y E++ L + L E+A
Sbjct: 1316 EELKHQLEE---ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1372
Query: 686 KYKLAEKTET--------SHEQWLFKRLQEEEAKSGHLSREVDAL-KEKIHEYMATEDLI 736
+++ +T+ ++ L +RLQE E ++ + +L K K EDL+
Sbjct: 1373 QWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1432
Query: 737 CHLQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERYRHFSKSLRPSL 785
++ ++ +Q N ++ L ++ E ELE + S+SL L
Sbjct: 1433 LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Score = 110 bits (274), Expect = 1e-23
Identities = 178/772 (23%), Positives = 329/772 (42%), Gaps = 111/772 (14%)
Query: 82 ELQARDEVIGI-LKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
ELQAR E +G ++AE+ A E Q ++ +++ E +R +T Q ++ +K
Sbjct: 1113 ELQARIEELGEEIEAERASRAKAEKQRSDLS-RELEEISERLEEAGGATSAQVELNKKRE 1171
Query: 141 NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
E K+ +E+ + + K ++ EL E+ + +K LE+E
Sbjct: 1172 AEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQK-------LEKEK 1224
Query: 201 ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
LK D + E + K EK +L++++++LK+ +EQQRL LT QR
Sbjct: 1225 SELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE----EEQQRLINDLTAQR 1280
Query: 258 QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNED 317
++Q T A E +L E++ ++L + Q T Q + + +L E
Sbjct: 1281 ARLQ---TEAGEYSRQL-------DEKDALVSQLSRSKQAST----QQIEELKHQLEEET 1326
Query: 318 SQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS------KGEYGNAGIMA- 370
L L + D L E ++ + ELQ K + + +Y I
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1386
Query: 371 -EVEELRKRVLD-MEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 428
E+EE +K++ ++ +E + + +C L K +R + +D L+VE+ + AL+
Sbjct: 1387 EELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446
Query: 429 KLEDAFNKS----KQECYSLKCNLEKERMTTKQLSQELESLK-VRIKELEAIESRLEKTE 483
K + F+K KQ+ + LE + ++ LS EL +K V + L+ +E+ L +
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLET-LRREN 1505
Query: 484 FTLKEDLTKLKTLTVMFVDERKTMSE--KLKKTEDK--------LQAASSQLQVEQNKVT 533
L+++++ L T + K + E K+KK ++ L+ A + L+ E+ K+
Sbjct: 1506 KNLQQEISDL---TEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKIL 1562
Query: 534 TVTEKLIE---ETKRALKSKTD-VEEKMYSVTKERDDLKNKLKAEEEKGNDLL------- 582
+ +L + E R + K + +++ + T+ + +++ L AE ND L
Sbjct: 1563 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622
Query: 583 SRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQEN-----NKIKE---------- 627
+N ++ +L + + L+N N T LH ++ +KE
Sbjct: 1623 GDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRAN 1682
Query: 628 -LSQEVERLKLKL----KDMKAIEDDLMKTEDEYETLERRYAN--------ERDKAQFLS 674
L E+E L L + K E +L+ + + L + + E D +Q L
Sbjct: 1683 LLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQ-LQ 1741
Query: 675 KELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKI----HEYM 730
E+E V E + K + + + L++E+ S HL R L++ + H
Sbjct: 1742 SEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1801
Query: 731 ATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 782
E L L+G +K++ + E R R+L E+EN E +R K LR
Sbjct: 1802 EAEQLA--LKGG----KKQIQKLEARVRELEGEVEN---EQKRNAEAVKGLR 1844
Score = 109 bits (272), Expect = 2e-23
Identities = 105/545 (19%), Positives = 255/545 (46%), Gaps = 69/545 (12%)
Query: 287 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK 346
K+ EKE+ T +F + +D +L +++ ++L++K+ L ++ ++L+ ++
Sbjct: 844 KSAETEKEMATMKEEFQKTKD----ELAKSEAKRKELEEKMVTLLKEKNDLQ---LQVQS 896
Query: 347 AEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI----KMEEQCRDLNK- 401
+ L D +E+ + + A+++E+ +R + E + EL K+E++C +L K
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD 956
Query: 402 ---------RLERETLQS----KDFKLEVEKLSKRIMALEKLEDAFNKSKQECYS-LKCN 447
++E+E + K+ E+ L + I L K + A ++ Q+ L+
Sbjct: 957 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAE 1016
Query: 448 LEKERMTTK---QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDER 504
+K + TK +L Q+++ L+ +++ + + LE+ + L+ DL + T+ +++
Sbjct: 1017 EDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDK 1076
Query: 505 KTMSEKLKKTEDKL----------QAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE 554
+ + EKL+K E ++ QA QLQ + ++ E+L EE + S+ E
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 1136
Query: 555 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDS--- 611
++ +++E +++ +L EE G ++V + K R + + +D + L ++
Sbjct: 1137 KQRSDLSRELEEISERL---EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVA 1193
Query: 612 ------GKSTTALHQENNKIKELSQEVER----LKLKLKDMKAIEDDLMKTEDEYETLER 661
S L ++ + ++ + Q++E+ LK++ D+ + + + K + E + R
Sbjct: 1194 ALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCR 1253
Query: 662 RYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR---- 717
++ + + +E + + +L + +TE ++L E++A LSR
Sbjct: 1254 SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYS---RQLDEKDALVSQLSRSKQA 1310
Query: 718 ---EVDALKEKIHEYMATEDLICHL----QGDHSVLQKKLNQQENRNRDLGREIENLTKE 770
+++ LK ++ E ++ + H + D +L+++ +++ +L R + E
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1370
Query: 771 LERYR 775
+ ++R
Sbjct: 1371 VAQWR 1375
Score = 85.9 bits (211), Expect = 2e-16
Identities = 127/624 (20%), Positives = 271/624 (43%), Gaps = 66/624 (10%)
Query: 79 LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKS------TPWQ 132
LE E +A++ + L++ + D LL QY K LQR +A S T ++
Sbjct: 1322 LEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKA--ELQRALSKANSEVAQWRTKYE 1379
Query: 133 EDIY------EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYM 186
D E+ +L + +++ +E + + EK++++ E+E+ +
Sbjct: 1380 TDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD----V 1435
Query: 187 EKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTTLKEELTKLKSFALMVV 243
E+S+ L+++ K++ + + EE + E E K +L EL K+K+ +
Sbjct: 1436 ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESL 1495
Query: 244 DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 303
D+ + L + +Q+I +LT E ++ E ++ EQ+ ++ L+
Sbjct: 1496 DQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE 1555
Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEY 363
++ I+ + ++ +K+A +ID+L+ + + + + D
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD---------- 1605
Query: 364 GNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQS--------KDFKL 415
A I + + LR + MEG +L +ME Q N RL E+L++ K+ +L
Sbjct: 1606 --AEIRSRNDALRVK-KKMEG---DLNEMEIQLNHAN-RLAAESLRNYRNTQGILKETQL 1658
Query: 416 EVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKE 471
++ + L++ +E N + E L LE+ + K QEL R++
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL 1718
Query: 472 LEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNK 531
L + L T+ L+ D+++L++ + E + EK KK + +L+ EQ+
Sbjct: 1719 LHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDT 1778
Query: 532 VTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK 589
+ +K +E+T + L+ + D E++ LK +++ L +RV L+
Sbjct: 1779 SAHLERMKKNLEQTVKDLQHRLDEAEQL------------ALKGGKKQIQKLEARVRELE 1826
Query: 590 NRLQSLEAIEKDFLKN-KLNQDSGKSTTALHQENNK-IKELSQEVERLKLKLKDMKAIED 647
+++ + + +K + ++ K T +E+ K + L V++L+ K+K K +
Sbjct: 1827 GEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE 1886
Query: 648 DLMKTEDEYETLERRYANERDKAQ 671
+ + + + R+ +E ++A+
Sbjct: 1887 EAEEQSNANLSKFRKLQHELEEAE 1910
Score = 80.9 bits (198), Expect = 6e-15
Identities = 108/507 (21%), Positives = 215/507 (42%), Gaps = 82/507 (16%)
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSD------ 190
+K DKV+ + K+ Y +L ++K R EL + K ++E +++ +
Sbjct: 1446 DKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRREN 1505
Query: 191 -----EFICLLEQ---------ECERLKKLIDQE-------IKSQEEKEQEKEKRVTTLK 229
E L EQ E E++KK ++QE ++ E + +E ++ ++
Sbjct: 1506 KNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565
Query: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEE-EQKA 288
EL ++KS + E+ QL ++ E + + + RV+++ E
Sbjct: 1566 LELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDL 1625
Query: 289 TRLEKELQ------TQTTKFHQDQDTIM--AKLTNEDSQNRQ--LQQKLAALSR------ 332
+E +L ++ + +++ I+ +L +D+ Q L+++LA + R
Sbjct: 1626 NEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQ 1685
Query: 333 -QIDEL----EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 387
+I+EL E+T RS + AE+EL D E++ N ++ ++L V ++ + E
Sbjct: 1686 AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVE 1745
Query: 388 ELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 447
E+I+ + K+ D + E+L K LE +Q L+
Sbjct: 1746 EVIQESRNAEEKAKKA------ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1799
Query: 448 L-EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTK----LKTLTVMFVD 502
L E E++ K ++++ L+ R++ELE +K + L K +K LT +
Sbjct: 1800 LDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEE 1859
Query: 503 ERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTK 562
+RK + +L+ DKLQA + K + + EE+ +
Sbjct: 1860 DRKNVL-RLQDLVDKLQA---------------------KVKSYKRQAEEAEEQSNANLS 1897
Query: 563 ERDDLKNKLKAEEEKGNDLLSRVNMLK 589
+ L+++L+ EE+ + S+VN L+
Sbjct: 1898 KFRKLQHELEEAEERADIAESQVNKLR 1924
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 116 bits (290), Expect = 1e-25
Identities = 164/756 (21%), Positives = 308/756 (40%), Gaps = 130/756 (17%)
Query: 132 QEDIYEKPMN----------ELDKVVEKHKESYRRILGQLLVAEKSRR--QTILELEEEK 179
QE++ EK N + +++ K+ +I+ +A K+ Q ++E E+
Sbjct: 675 QEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKI 734
Query: 180 RKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEK-EQEKEKRVTTLKEELTKLKSF 238
R + + E ICL ++ +++ +E++ Q E+ E + EK+ KE+ +
Sbjct: 735 RSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSML 794
Query: 239 ALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE------ 292
++ +Q L + L + E+ + L + +V EE K +L+
Sbjct: 795 QQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEIC 854
Query: 293 -KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 351
+EL + +++ +L + + LQ++L + + E E N L+ ++
Sbjct: 855 KEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQ 914
Query: 352 QDI--KEKISKGEYGNAGIMAEVE------ELRKRVLDMEGKDEELIKMEEQCR------ 397
Q + +E I GE + E + EL+K+ E E+L KMEE+C
Sbjct: 915 QQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ---RESSAEKLRKMEEKCESAAHEA 971
Query: 398 --------DLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLE 449
+L + ++ +K E+ K+ K IM L++ D NK+ +L
Sbjct: 972 DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKR--DGENKAM--------HLS 1021
Query: 450 KERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD---ERKT 506
+ M Q ELE +KELE ++ TE L E L K + L + E K+
Sbjct: 1022 QLDMILDQTKTELEKKTNAVKELEKLQ---HSTETELTEALQKREVLETELQNAHGELKS 1078
Query: 507 MSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK------MYSV 560
+L++ D LQ A L+ + + +T +L E K ++E+K M
Sbjct: 1079 TLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRE-------CKMEIEDKKQELLEMDQA 1131
Query: 561 TKERD-DLKNK--------LKAEEEKGNDLLSRVNMLKNRLQSLEAIEK----------D 601
KER+ +LK + + E +G ++ ++ L+ L+ E K D
Sbjct: 1132 LKERNWELKQRAAQVTHLDMTIREHRG-EMEQKIIKLEGTLEKSELELKECNKQIESLND 1190
Query: 602 FLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAI---------------- 645
L+N Q K L Q +I +L +E+ER + ++K+M+++
Sbjct: 1191 KLQNAKEQLREKEFIML-QNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAI 1249
Query: 646 --EDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK 703
+L T ++ + A R + +E+E + EL K K + +H L +
Sbjct: 1250 DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAE 1309
Query: 704 RLQEEEAKSGH-----------LSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQ 752
L + + H LS EV++LKE H ++I H Q +H+ + +
Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYH-----MEMISH-QENHAKWKISADS 1363
Query: 753 QENRNRDLGREIENLTKELERYRHFSKSLRPSLNGR 788
Q++ + L ++E ELE + +L + R
Sbjct: 1364 QKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDR 1399
Score = 97.1 bits (240), Expect = 9e-20
Identities = 155/721 (21%), Positives = 306/721 (42%), Gaps = 101/721 (14%)
Query: 190 DEFICLLEQECERLKKLIDQEIKSQEEKEQ---EKEKRVTTLKEELTKLKSFALMVVDEQ 246
+E I LE E K++ + E+ ++ EKE+ + KEE KLK VD
Sbjct: 290 EEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLK------VDLL 343
Query: 247 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQ 306
++ +RQ+ E NA+E L++A Q +++ A +LEK ++
Sbjct: 344 EQTKQGKRAERQR-NEALYNAEE------LSKAFQQYKKKVAEKLEK--------VQAEE 388
Query: 307 DTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA 366
+ + LTN + +N++LQ++ +++ L+E LR+ +EE + KEK+ N+
Sbjct: 389 EILERNLTNCEKENKRLQERCGLYKSELEILKE---KLRQLKEENNNGKEKLRIMAVKNS 445
Query: 367 GIMAEVEELRKRVL----DMEGKDEEL---IKMEEQCRDLNKRLERETLQSKDFKLEVEK 419
+MA++ E R+ +L ++E KDE L + + R+L R+ + + + E+E
Sbjct: 446 EVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIES 505
Query: 420 LSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQE-----LESLKVRIKELE- 473
+ +LEK+ K+E + K L K +M++ ++ E+ K+ I EL
Sbjct: 506 SRVELRSLEKIISQL-PLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRI 564
Query: 474 --AI-ESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQN 530
AI E+ ++K L + +T E +S L+ KL V+
Sbjct: 565 KLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLS-SLETEPVKLGGHQVAESVKDQ 623
Query: 531 KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLK--------------NKLKAEEE 576
T+ ++ +E +R + ++ K+ + E DLK +L +
Sbjct: 624 NQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKAS 683
Query: 577 KGNDLLSRVNMLKNRLQSLE--AIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEV-- 632
+ L S + ++L +LE EK + + + + L ++N KI+ L +
Sbjct: 684 NSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINT 743
Query: 633 ----------ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKE------ 676
+ K+ L+ K +E + + E + E ++++ + L ++
Sbjct: 744 EHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQH 803
Query: 677 -LEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
LE + L + K K E + K LQ + ++ R++D+ E + E+L
Sbjct: 804 HLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE-----ICKEEL 858
Query: 736 ICH---LQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISD 792
+ H L+G+ +K+L ++ L +E++ L+ + L+ +L
Sbjct: 859 VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTL------- 911
Query: 793 PQVFSKEVQTEAVDN-EPPDYKSLIPLERAVINGQLYEESENQDEDPNDEGSVLSFKCSQ 851
Q + +Q E + N E D ++ LE+ V +L +E + Q E ++ + KC
Sbjct: 912 -QQQQQMLQQETIRNGELEDTQT--KLEKQV--SKLEQELQKQRESSAEKLRKMEEKCES 966
Query: 852 S 852
+
Sbjct: 967 A 967
Score = 77.4 bits (189), Expect = 7e-14
Identities = 153/708 (21%), Positives = 292/708 (41%), Gaps = 141/708 (19%)
Query: 162 LVAEKSRRQTILELEEEKRKHKEYME-KSDEFICLLEQECERLKKLIDQEIKSQEEKEQE 220
L AE S + +L E K + + M + ++ + ++EC +LK + ++ K + E++
Sbjct: 296 LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQ 355
Query: 221 KEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEAR 280
+ + + EEL+K Q+ K K+ KL +A
Sbjct: 356 RNEALYN-AEELSK-------------------AFQQYK--------KKVAEKLEKVQAE 387
Query: 281 VQEEEQKATRLEKE---LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAAL----SRQ 333
+ E+ T EKE LQ + + + + + KL +N ++KL + S
Sbjct: 388 EEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEV 447
Query: 334 IDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGK----DEEL 389
+ +L E+ +S+ K E EL++ K++I + ++ +M E EL+ RV + +E+
Sbjct: 448 MAQLTESRQSILKLESELEN-KDEILRDKF---SLMNENRELKVRVAAQNERLDLCQQEI 503
Query: 390 IKMEEQCRDLNK-----RLERETLQSKDF--KLEVEKLSKR-----------IMALEKLE 431
+ R L K L+RE K + K ++ S + + + +L
Sbjct: 504 ESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELR 563
Query: 432 DAFNKSKQECYSLKCNLEKERMTTKQLSQEL-------ESLKVRIKELEAIESRLEKTEF 484
+ E L NL T QLSQ L ES K+ E E ++ +
Sbjct: 564 IKLAIKEAEIQKLHANL-----TANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAE 618
Query: 485 TLKEDLTKLKTLTVMFVDERK---TMSEKLKKTEDKLQAASSQLQVEQNKVTT----VTE 537
++K+ T+ + ER+ T E+L+ +++A +S L+V T+ + E
Sbjct: 619 SVKDQ--NQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQE 676
Query: 538 KLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE---KGNDLLSRVNMLKNRLQS 594
+L+E+ + K ++++ +K + L+ K+ A K +L + +++S
Sbjct: 677 ELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRS 736
Query: 595 LEA-IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL-----------KDM 642
LE I + K L + K +H E + KE+ +++ERL+ +L K M
Sbjct: 737 LETNINTEHEKICLAFEKAKK---IHLEQH--KEMEKQIERLEAQLEKKDQQFKEQEKTM 791
Query: 643 KAIEDDL-------------------------MKTEDEYETLERRYANERDKAQFLSKEL 677
++ D+ MK ++ + L+ + + E K + L L
Sbjct: 792 SMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSAL 851
Query: 678 EHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 737
E K EL + + E + E++ K+L+++ + L +E LK K H T +
Sbjct: 852 EICKEELVLH--LNQLEGNKEKF-EKQLKKKSEEVYCLQKE---LKIKNHSLQETSEQNV 905
Query: 738 HLQGDHSVLQKKLNQQENRNRD-------LGREIENLTKELERYRHFS 778
LQ Q+ L Q+ RN + L +++ L +EL++ R S
Sbjct: 906 ILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESS 953
Score = 53.9 bits (128), Expect = 8e-07
Identities = 84/441 (19%), Positives = 198/441 (44%), Gaps = 67/441 (15%)
Query: 29 KNMKHRQQDKDSP----SESDVILPCPKAEKPHSGNG-------HQAEDLSRDDLLFLLS 77
K + H ++D ++ S+ D+IL K E N + + + L
Sbjct: 1004 KEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKRE 1063
Query: 78 ILEGELQ-ARDEVIGILKA-EKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDI 135
+LE ELQ A E+ L+ +++ L +AQ ++ L + + K + +
Sbjct: 1064 VLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKM---EIED 1120
Query: 136 YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICL 195
++ + E+D+ +++ ++ Q+ + + R+ E+E++ K + +EKS+ L
Sbjct: 1121 KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE----L 1176
Query: 196 LEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL 255
+EC + + ++ ++++ +E+ +EKE + ++E+++LK + QQR+ ++
Sbjct: 1177 ELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKK---EIERTQQRMKEMESV 1233
Query: 256 QRQKIQELTTNAKE-----------------THTKLALAEARVQEEEQKATRLEKELQTQ 298
+++ Q + T KE +HT+LA A + + +++ RL EL+
Sbjct: 1234 MKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELED- 1292
Query: 299 TTKFHQDQDTIMAKLTNE-DSQNRQLQQKLAALSRQIDELEETNRS-LRKAEEELQDIKE 356
M +L+ E D+ L ++L A + LE ++ ++K E++ +KE
Sbjct: 1293 -----------MKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKE 1341
Query: 357 KISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 416
+ +++ E K + + + + + LN++LE+ L+ ++ +
Sbjct: 1342 AY------HMEMISHQENHAKWKISADSQKSSV-------QQLNEQLEKAKLELEEAQDT 1388
Query: 417 VEKLSKRIMALEKLEDAFNKS 437
V L +++ ++ +A N++
Sbjct: 1389 VSNLHQQVQDRNEVIEAANEA 1409
Score = 49.7 bits (117), Expect = 2e-05
Identities = 66/301 (21%), Positives = 125/301 (41%), Gaps = 43/301 (14%)
Query: 114 KVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHK-ESYRRILGQLLVAEKSR---- 168
K E L+ D K W+ + LD + +H+ E ++I+ EKS
Sbjct: 1121 KKQELLEMDQ-ALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELK 1179
Query: 169 --RQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLID---QEIKSQEEKEQEKEK 223
+ I L ++ + KE + + + + EQE +LKK I+ Q +K E +E+E+
Sbjct: 1180 ECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQ 1239
Query: 224 RVTTLKEELTKL------------KSFALMVVDEQQRLTAQLTLQR--QKIQELTTNAKE 269
+ T +E L S + Q++ AQ ++R +++++ +KE
Sbjct: 1240 YIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKE 1299
Query: 270 -----THTKLALAEARVQEEEQKAT------RLEKELQTQTTKFHQD----QDTIMAKLT 314
H L ++V+E +A +L E+++ +H + Q+
Sbjct: 1300 KDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKI 1359
Query: 315 NEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEE 374
+ DSQ +QQ L + ELEE ++ +++QD E I E N ++ + E
Sbjct: 1360 SADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVI---EAANEALLTKGEN 1416
Query: 375 L 375
+
Sbjct: 1417 V 1417
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 115 bits (289), Expect = 2e-25
Identities = 135/650 (20%), Positives = 282/650 (43%), Gaps = 90/650 (13%)
Query: 217 KEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL 276
K E+EK + ++KEE T+LK ++ L ++ Q+ +L + LA
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900
Query: 277 AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
AE R + + +LE +++ + +D++ + A+LT ++ R+L+ + + L R ID+
Sbjct: 901 AEERCDQLIKNKIQLEAKVKEMNERL-EDEEEMNAELT---AKKRKLEDECSELKRDIDD 956
Query: 337 LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVL--------DMEGKDEE 388
LE T + K + ++ + +++ G I+A++ + +K + D++ ++++
Sbjct: 957 LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK 1016
Query: 389 L-------IKMEEQCRDLNKRLERETLQSKDFKLEVEKL-------SKRIMALE----KL 430
+ +K+E+Q DL LE+E D + KL + IM LE +L
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076
Query: 431 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------AIESRLEKTE 483
++ K E +L +E E+ QL ++L+ L+ RI+ELE +++EK
Sbjct: 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLR 1136
Query: 484 FTLKEDLTKLKT-------LTVMFVDERKTMSEKLKKTEDKLQAAS-------------- 522
L +L ++ T + ++ K + +K L+ A+
Sbjct: 1137 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1196
Query: 523 ----SQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKG 578
++L + + + V +KL +E DV M + K + +L+ + E++
Sbjct: 1197 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256
Query: 579 NDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKEL-------SQE 631
N+ S+ + + L + + KL ++G+ + L ++ I +L +Q+
Sbjct: 1257 NEHRSKAEETQRSVNDLTS-----QRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311
Query: 632 VERLKLKL----KDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKY 687
+E LK +L K A+ L + + L +Y E + L + L E+A++
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQW 1371
Query: 688 KLAEKTET--------SHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYM-ATEDLICH 738
+ +T+ ++ L +RLQE E ++ + +L++ H EDL+
Sbjct: 1372 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVD 1431
Query: 739 LQGDHSVLQKKLNQQENRNRDLG---REIENLTKELERYRHFSKSLRPSL 785
++ ++ +Q N ++ L ++ E ELE + ++SL L
Sbjct: 1432 VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Score = 107 bits (268), Expect = 5e-23
Identities = 176/818 (21%), Positives = 352/818 (43%), Gaps = 98/818 (11%)
Query: 82 ELQAR-DEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEKPM 140
ELQAR +E+ L+AE+ A +E ++ +++ E +R +T Q ++ +K
Sbjct: 1110 ELQARIEELEEELEAERTARAKVEKLRSDLS-RELEEISERLEEAGGATSVQIEMNKKRE 1168
Query: 141 NELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQEC 200
E K+ +E+ + K ++ EL E+ + +K LE+E
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK-------LEKEK 1221
Query: 201 ERLKKLIDQEIKSQEEKEQEK---EKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQR 257
K +D + E+ + K EK TL++++ + +S A +E QR LT QR
Sbjct: 1222 SEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA----EETQRSVNDLTSQR 1277
Query: 258 QKIQ----ELTTNAKETHTKLA-LAEARV---QEEEQKATRLEKELQTQTTKFH------ 303
K+Q EL+ E ++ L ++ Q+ E +LE+E++ + H
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 304 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQI---------------DELEETNRSL---- 344
D D + + E +LQ+ L+ + ++ +ELEE + L
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1397
Query: 345 RKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 404
++AEE ++ + K S E + E+E+L ++D+E + ++++ R+ +K L
Sbjct: 1398 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL---MVDVERSNAAAAALDKKQRNFDKILA 1454
Query: 405 RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQ 460
+ ++ + E+E K +L KL++A+ +S + + K + + L++
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE 1514
Query: 461 ELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK----KTED 516
+L S I ELE + +LE + L+ L + + + +E K + +L+ K E
Sbjct: 1515 QLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS--LEHEEGKILRAQLEFNQIKAEI 1572
Query: 517 KLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE 576
+ + A ++EQ K + ++++ + +L ++T + V K+ + N+++ +
Sbjct: 1573 ERKLAEKDEEMEQAKRNHL--RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS 1630
Query: 577 KGNDLLSRVNMLKNRLQSLEAIEKDFLKN--KLNQDSGKSTTALHQENN----KIKELSQ 630
N + + LQSL + L + + N D ++ + + NN +++EL
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1690
Query: 631 EVERLKLKLKDMKAIEDDLMKTEDEYETLERRYA---NERDKAQF----LSKELEHVKME 683
VE+ + + K E +L++T + + L + N++ K L E+E E
Sbjct: 1691 VVEQTE---RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 684 LAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDH 743
+ K + + + L++E+ S HL R +++ I +DL L
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTI------KDLQHRLDEAE 1801
Query: 744 SVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTE 803
+ K +Q + RE+EN ELE + K S+ G R S+ ++ QTE
Sbjct: 1802 QIALKGGKKQLQKLEARVRELEN---ELEAEQ---KRNAESVKGMRKSERRIKELTYQTE 1855
Query: 804 AVDNEPPDYKSLIPLERAVINGQLYEESENQDEDPNDE 841
D K+L+ L+ V QL ++ + + +E
Sbjct: 1856 ------EDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEE 1887
Score = 103 bits (258), Expect = 7e-22
Identities = 158/739 (21%), Positives = 331/739 (44%), Gaps = 110/739 (14%)
Query: 79 LEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYEK 138
L E+ DE+I L EK AL EA ++ L+ LQ + + + + E+
Sbjct: 978 LTEEMAGLDEIIAKLTKEKK--ALQEAH------QQALDDLQAEEDKVNTLTKAKVKLEQ 1029
Query: 139 PMNELDKVVEKHKE-------SYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDE 191
+++L+ +E+ K+ + R++ G L + ++S I++LE +K++ E ++K D
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQES----IMDLENDKQQLDERLKKKDF 1085
Query: 192 FICLLEQECERLKKLIDQEIKSQ-EEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLT 250
+ L E +Q + SQ ++K +E + R+ L+EEL ++ V ++L
Sbjct: 1086 ELNALNARIED-----EQALGSQLQKKLKELQARIEELEEELEAERTARAKV----EKLR 1136
Query: 251 AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIM 310
+ L+ ++++E++ +E ++ ++ E + ++ ++L+ T + +
Sbjct: 1137 SDLS---RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALR 1193
Query: 311 AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMA 370
K + DS +A L QID L+ + L K + E + + ++ A
Sbjct: 1194 KK--HADS--------VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243
Query: 371 EVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE--KLSKRIMALE 428
+E++ + + D +E K EE R +N L S+ KL+ E +LS+++ E
Sbjct: 1244 NLEKMCRTLEDQ--MNEHRSKAEETQRSVN------DLTSQRAKLQTENGELSRQLDEKE 1295
Query: 429 KLEDAFNKSK----QECYSLKCNLEKERMTTKQLSQELESLK-----VRIKELEAIESR- 478
L + K Q+ LK LE+E L+ L+S + +R + E E++
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA 1355
Query: 479 -----LEKTEFTLKEDLTKLKTLTVMFVDE----RKTMSEKLKKTEDKLQAAS---SQLQ 526
L K + + TK +T + +E +K ++++L++ E+ ++A + S L+
Sbjct: 1356 ELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLE 1415
Query: 527 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTK-------ERDDLKNKLKAEEEKGN 579
++++ E L+ + +R+ + +++K + K + ++ +++L++ +++
Sbjct: 1416 KTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1475
Query: 580 DLLSRVNMLKNRL-QSLEAIEKDFLKNK-LNQDSGKSTTALHQENNKIKELSQEVERLKL 637
L + + LKN +SLE +E +NK L ++ T L I EL
Sbjct: 1476 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELE-------- 1527
Query: 638 KLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSH 697
K K +E + M+ + E E +E K E +K E+ + KLAEK E
Sbjct: 1528 --KVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER-KLAEKDE--- 1581
Query: 698 EQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICH----LQGDHSVLQKKLNQQ 753
+ E+AK HL R VD+L+ + + + ++GD + ++ +L+
Sbjct: 1582 --------EMEQAKRNHL-RVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632
Query: 754 ENRNRDLGREIENLTKELE 772
+ +++++L L+
Sbjct: 1633 NRMAAEAQKQVKSLQSLLK 1651
Score = 94.0 bits (232), Expect = 7e-19
Identities = 124/626 (19%), Positives = 267/626 (42%), Gaps = 46/626 (7%)
Query: 63 QAEDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD 122
Q EDL R LE E++A++ + L++ + D LL QY T K LQR
Sbjct: 1311 QLEDLKRQ--------LEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKA--ELQRV 1360
Query: 123 AFQAKS--TPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKR 180
+A S W+ YE + + +E+ K+ + L + A ++ LE+ K
Sbjct: 1361 LSKANSEVAQWRTK-YETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKH 1419
Query: 181 KHKEYME-------KSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKE---KRVTTLKE 230
+ + +E +S+ L+++ K++ + + EE + E E K +L
Sbjct: 1420 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1479
Query: 231 ELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATR 290
EL KLK+ ++ + + +++I +LT + + E ++ E +
Sbjct: 1480 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKME 1539
Query: 291 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE 350
L+ L+ ++ I+ + ++++KLA + +E+E+ R+ + +
Sbjct: 1540 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA---EKDEEMEQAKRNHLRVVDS 1596
Query: 351 LQDIKEKISKGEYGNAGIMAEVE-ELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ 409
LQ + ++ + ++E +L + + + + + ++Q + L L+ +Q
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1656
Query: 410 SKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRI 469
D + L + I +E+ + +E L+ +E+ + K QEL R+
Sbjct: 1657 LDDAVRANDDLKENIAIVERRNNLLQAELEE---LRAVVEQTERSRKLAEQELIETSERV 1713
Query: 470 KELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQ 529
+ L + + L + + DL++L+T V E + EK KK + +L+ EQ
Sbjct: 1714 QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQ 1773
Query: 530 NKVTTV--TEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNM 587
+ + +K +E+T + L+ + D E++ LK +++ L +RV
Sbjct: 1774 DTSAHLERMKKNMEQTIKDLQHRLDEAEQI------------ALKGGKKQLQKLEARVRE 1821
Query: 588 LKNRLQSLEAIEKDFLK--NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAI 645
L+N L++ + + +K K + + T ++ + L V++L+LK+K K
Sbjct: 1822 LENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ 1881
Query: 646 EDDLMKTEDEYETLERRYANERDKAQ 671
++ + + + R+ +E D+A+
Sbjct: 1882 AEEAEEQANTNLSKFRKVQHELDEAE 1907
Score = 84.0 bits (206), Expect = 8e-16
Identities = 102/500 (20%), Positives = 223/500 (44%), Gaps = 56/500 (11%)
Query: 137 EKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLL 196
+K DK++ + K+ Y +L ++K R EL + K ++E +E + F
Sbjct: 1443 DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF---- 1498
Query: 197 EQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQ 256
+R K + +EI E+ K + L++ +L++ + + + A L +
Sbjct: 1499 ----KRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 257 RQKIQ----ELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAK 312
KI E E KLA + +++ ++ R+ LQT + ++ +
Sbjct: 1555 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 313 LTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ-----------DIKEKISKG 361
+ +++ +L+ +R E ++ +SL+ ++ Q D+KE I+
Sbjct: 1615 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1674
Query: 362 EYGNAGIMAEVEELRKRVLDMEGK----DEELIKMEEQCRDLNKRLERETLQSKDFKLEV 417
E N + AE+EELR V E ++ELI+ E+ + L+ + Q K ++
Sbjct: 1675 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADL 1734
Query: 418 EKLSKRIM-ALEKLEDAFNKSKQ---ECYSLKCNLEKERMTT-------KQLSQELESLK 466
+L + A+++ +A K+K+ + + L+KE+ T+ K + Q ++ L+
Sbjct: 1735 SQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ 1794
Query: 467 VRIKELEAI-----ESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLK---KTEDKL 518
R+ E E I + +L+K E ++E +L+ E+K +E +K K+E ++
Sbjct: 1795 HRLDEAEQIALKGGKKQLQKLEARVRELENELEA-------EQKRNAESVKGMRKSERRI 1847
Query: 519 QAASSQLQVEQN---KVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEE 575
+ + Q + ++ ++ + +KL + K + + EE+ + + ++++L E
Sbjct: 1848 KELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAE 1907
Query: 576 EKGNDLLSRVNMLKNRLQSL 595
E+ + S+VN L+ + + +
Sbjct: 1908 ERADIAESQVNKLRAKSRDI 1927
Score = 66.2 bits (160), Expect = 2e-10
Identities = 116/585 (19%), Positives = 242/585 (41%), Gaps = 79/585 (13%)
Query: 255 LQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLT 314
L R+ + +L TN + TH + E + ++ L + + + I ++
Sbjct: 650 LHRENLNKLMTNLRSTHPHFV--RCIIPNETKSPGVMDNPLVMHQLRCNGVLEGI--RIC 705
Query: 315 NEDSQNRQL----QQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN----- 365
+ NR L +Q+ L+ + S + AE+ L + ++ ++G+
Sbjct: 706 RKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFF 765
Query: 366 -AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE-RETLQSKDFKLEVE----- 418
AG++ +EE+R L + +++ Q R + R+E ++ L+ +D L ++
Sbjct: 766 KAGLLGLLEEMRDERLS-----RIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRA 820
Query: 419 ----------KLSKRIMALEKL---EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 465
KL +I L K E K+E LK LEK K+L +++ SL
Sbjct: 821 FMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSL 880
Query: 466 KVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQL 525
+L+ + +E +L + + K M+E+L+ E+
Sbjct: 881 LQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEM-------- 932
Query: 526 QVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLK--AEEEKGNDLLS 583
++T KL +E + D+E + V KE+ +NK+K EE G D
Sbjct: 933 ---NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD--- 986
Query: 584 RVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMK 643
+ + + K+ K L + ++ L E +K+ L++ +L+ ++ D++
Sbjct: 987 ---------EIIAKLTKE--KKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLE 1035
Query: 644 AIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFK 703
+ K + E +R+ + Q +LE+ K +L + + E + L
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA---LNA 1092
Query: 704 RLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE 763
R+++E+A L +++ L+ +I E+L L+ + + K E DL RE
Sbjct: 1093 RIEDEQALGSQLQKKLKELQARI------EELEEELEAERTARAK----VEKLRSDLSRE 1142
Query: 764 IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 808
+E +++ LE + S++ +N +R ++ Q ++++ + +E
Sbjct: 1143 LEEISERLEE-AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE 1186
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 115 bits (287), Expect = 3e-25
Identities = 175/758 (23%), Positives = 309/758 (40%), Gaps = 171/758 (22%)
Query: 155 RRILGQLLVAE--KSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIK 212
R+I G + E K ++Q I +L E+ + + K+ + +EQE + DQ +
Sbjct: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
Query: 213 SQEEK-----------EQEKEKRVTTLKEELTKLKSFALMVVDE---QQRLTAQLTLQRQ 258
E K ++EK + + L+EE K++ V +E + L Q L+
Sbjct: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464
Query: 259 KIQEL-------TTNAKETHTKLALAEARVQEEEQKATRLEKEL------------QTQT 299
+I+EL T A + +L E+ + LEK+L + ++
Sbjct: 465 RIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLES 524
Query: 300 TKFHQDQDTIMAKLTNEDSQNRQL-------QQKLAALSRQIDELEETNRSLRKAEEELQ 352
K D D ++ L S +L Q+++ +L EET++ KA L
Sbjct: 525 NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKA---LY 581
Query: 353 DIKEKISKGEYGNAGIMAEVEELRKRVLDM----EGKDEELI-----KMEEQCRDLNKRL 403
EK+SK N + +++E K D+ + K E I MEE +K L
Sbjct: 582 TATEKLSK---ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638
Query: 404 ERETLQSKDFKLEVEKL----------------------SKRIMALE-KLEDAFNKSKQE 440
ET + + K ++EK+ +K + AL KL + +
Sbjct: 639 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698
Query: 441 CYSLKCNLEKER----MTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTL 496
+++ L+K + + +L+ ++++KELE ++++ + + ++LK
Sbjct: 699 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758
Query: 497 TVMFVD---ERKTMSE---KLKKTEDKLQAASSQ---LQVEQN----KVTTVTEKL---- 539
+D RK SE ++KK +L+AA Q L++E+N K +++T +L
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
Query: 540 -------------------IEETKRALKSK-TDVEEKMYSVTKERDDLKNKLKAEEEKGN 579
+E+ + LK K + E+ SV + + NKL +EE+ N
Sbjct: 819 LKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN 878
Query: 580 DLLSRVNMLKNRLQSLEA--IEKD-------FLKNKLNQD-------SGKSTTALHQENN 623
L S + L+ L +EA EKD K KL D SG +++ L + N+
Sbjct: 879 MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938
Query: 624 KIKELSQEVERLKLKLKD--------MKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 675
+++ ++VE L+LKL K+IED +K E + +++ E+ K
Sbjct: 939 ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK-------K 991
Query: 676 ELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDL 735
ELE +L K K ETSH Q + + E A S ++ + L+ + TED
Sbjct: 992 ELERKLSDLEK-----KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED- 1045
Query: 736 ICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 773
KL N L +E+E L K+ ++
Sbjct: 1046 -------------KLKGAREENSGLLQELEELRKQADK 1070
Score = 114 bits (284), Expect = 7e-25
Identities = 151/680 (22%), Positives = 288/680 (42%), Gaps = 93/680 (13%)
Query: 114 KVLEALQRDAFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTIL 173
K +EAL+ A K +E+ E ++LDK ++H L +L AE +
Sbjct: 679 KEMEALR--AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK----VK 732
Query: 174 ELEEEKRKHKEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEK---------EKR 224
ELE + K E + D F L+ E+L L S E K + K EK+
Sbjct: 733 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 792
Query: 225 VTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEE 284
+ L+ E S A + E Q +LT ++ + E++ + +L + + + E
Sbjct: 793 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEA 852
Query: 285 EQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSL 344
++A +++ +Q K HQ ++ + S +L++ LA + + E +E L
Sbjct: 853 SEEAVSVQRSMQETVNKLHQKEE----QFNMLSSDLEKLRENLADMEAKFREKDEREEQL 908
Query: 345 RKAEEELQDIKEKISKGEYGNAGIMAEV-EELRKRVLDMEGKDEELIKMEEQCRDLNKRL 403
KA+E+L++ +I K N+ + ++ +ELR + D+E +L K E L K +
Sbjct: 909 IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 968
Query: 404 ERETLQSKDFKLEV-----EKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQL 458
E T++++ + E E+ + L LE S +C LK E+ TK
Sbjct: 969 EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTK 1028
Query: 459 SQE-LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDK 517
+E L++L+ + + E +K + +E+ L+ L E+L+K DK
Sbjct: 1029 HEEILQNLQKTLLDTE------DKLKGAREENSGLLQEL------------EELRKQADK 1070
Query: 518 LQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 577
+AA + Q + E++ +E L S D ++ + E D LK
Sbjct: 1071 AKAAQTAEDAMQ-----IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK--------- 1116
Query: 578 GNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLK- 636
+N L+++E + KS L EN K++E +E+E LK
Sbjct: 1117 -----------ENNLKNVEEL-------------NKSKELLTVENQKMEEFRKEIETLKQ 1152
Query: 637 ---LKLKDMKAIEDDLMKTEDEY----ETLERRYANERDKAQFLSKELEHVKMELAKYKL 689
K + + A++++ +K +E + + E +++ ++ LE K E K
Sbjct: 1153 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKD 1212
Query: 690 AEKTETSHEQWL---FKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVL 746
A++ + S ++ + L E++A+ L EV L+ + + ++ L+ D L
Sbjct: 1213 ADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKL 1272
Query: 747 QKKLNQQENRNRDLGREIEN 766
+ K+ E + ++ R++ +
Sbjct: 1273 ELKVKNLELQLKENKRQLSS 1292
Score = 92.8 bits (229), Expect = 2e-18
Identities = 151/743 (20%), Positives = 313/743 (42%), Gaps = 82/743 (11%)
Query: 136 YEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHK-EYMEKSDEFIC 194
+++ + L + +E++++ + L A + L E E K K E+ K + +
Sbjct: 555 HQREITSLKEHFGAREETHQKEIKALYTATEK-----LSKENESLKSKLEHANKENSDVI 609
Query: 195 LLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKS-FALMVVDEQQRLTAQL 253
L + +L+ I ++ EE + K + T E +LK+ M +D Q +
Sbjct: 610 ALWKS--KLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIE--- 664
Query: 254 TLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKL 313
LQ Q+ E +AKE A ++E+E + +L + + + + KL
Sbjct: 665 NLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL 724
Query: 314 TNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQD---IKEKISKGEYGNAGIMA 370
+ + ++L+ A + Q ++ L+ EE+L D +++ S+G+ +
Sbjct: 725 QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 784
Query: 371 EVEELRKRVLDME-GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRI-MALE 428
++E K++ +E K+ E K R+L R E + ++ EV ++ + + L+
Sbjct: 785 QLEAAEKQIKHLEIEKNAESSKASSITRELQGR-ELKLTNLQENLSEVSQVKETLEKELQ 843
Query: 429 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKE 488
L++ F ++ +E S++ ++++ T +L Q+ E + +LE + L E +E
Sbjct: 844 ILKEKFAEASEEAVSVQRSMQE---TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
Query: 489 DLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALK 548
DER+ E+L K ++KL+ +++ ++ K+ +E + LK
Sbjct: 901 K------------DERE---EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR--LK 943
Query: 549 SKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLN 608
+ DVEE +TK ++ K+ E D+ + + EK L+ KL+
Sbjct: 944 ER-DVEELQLKLTKANENASFLQKSIE----DMTVKAEQSQQEAAKKHEEEKKELERKLS 998
Query: 609 QDSGKSTTALHQENNKIKELSQEVERLKLKLKD-----MKAIEDDLMKTEDEYETLERRY 663
K T+ +N+ +EL ER + K ++ ++ L+ TED+ +
Sbjct: 999 DLEKKMETS----HNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLK------ 1048
Query: 664 ANERDKAQFLSKELEHVKMELAKYKLAEKTE---------TSHEQWLFKRLQEEEAKSGH 714
R++ L +ELE ++ + K K A+ E T + L++ + +
Sbjct: 1049 -GAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1107
Query: 715 LSREVDALKE----KIHEYMATEDLIC-------HLQGDHSVLQKKLNQQENRNRDLGRE 763
L E+D LKE + E +++L+ + + L++ Q+ + L E
Sbjct: 1108 LQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1167
Query: 764 IENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAV- 822
L +EL R R S + R + + Q+ + + + + K+ L++++
Sbjct: 1168 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA--SLQKSIS 1225
Query: 823 INGQLYEESENQDEDPNDEGSVL 845
I L E + + E +E +VL
Sbjct: 1226 ITSALLTEKDAELEKLRNEVTVL 1248
Score = 81.6 bits (200), Expect = 4e-15
Identities = 114/566 (20%), Positives = 247/566 (43%), Gaps = 85/566 (15%)
Query: 93 LKAEKMDLALLEAQYGFVTPKKVLEALQRDAFQAKSTPWQEDIYE--KPMNELDKVVEKH 150
L+A + + LE + + K + + K T QE++ E + L+K ++
Sbjct: 786 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQIL 845
Query: 151 KESYRRILGQLLVAEKSRRQTILELEEEKRKHKEYMEKSDEFICLLEQECERLKK-LIDQ 209
KE + + + ++S ++T+ +L +++ + +L + E+L++ L D
Sbjct: 846 KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN-----------MLSSDLEKLRENLADM 894
Query: 210 EIKSQEEKEQEKE--KRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNA 267
E K +E+ E+E++ K L+ ++ ++ + + ++ +L L+ + ++EL
Sbjct: 895 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 954
Query: 268 KETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTN----EDSQNRQL 323
+ + + + +++ KA E+ Q K +++ + KL++ ++ + Q
Sbjct: 955 TKANENASFLQKSIEDMTVKA---EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC 1011
Query: 324 QQKLAALSRQIDELEETNRS-LRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKR---- 378
Q+ A R E + + L+ ++ L D ++K+ N+G++ E+EELRK+
Sbjct: 1012 QELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA 1071
Query: 379 -----------VLDMEGKDE-ELIKMEEQCRDLNKRLERE--TLQSKDFKLEVEKL--SK 422
+++ K++ E + E + N +L+ E TL+ + K VE+L SK
Sbjct: 1072 KAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK-NVEELNKSK 1130
Query: 423 RIMALE--KLED-----------AFNKSKQECYSLKCNLE--------KERMTTKQ-LSQ 460
++ +E K+E+ A KS+Q + N++ ++ +T+ Q L +
Sbjct: 1131 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEE 1190
Query: 461 ELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQA 520
E L ++ E++ ES+ K K L K ++T + E+ EKL+ L+
Sbjct: 1191 ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG 1250
Query: 521 ASSQLQVEQNKVTTV-------------TEKLIEETKRALKSK-----TDVEEKMYSVTK 562
++ + + V T+ E ++E KR L S T +E +
Sbjct: 1251 ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQES 1310
Query: 563 ERDDLKNKLKAEEEKGNDLLSRVNML 588
+ D L + + + K DL +V M+
Sbjct: 1311 QIDFLNSVIVDLQRKNQDLKMKVEMM 1336
Score = 63.5 bits (153), Expect = 1e-09
Identities = 116/541 (21%), Positives = 233/541 (43%), Gaps = 100/541 (18%)
Query: 308 TIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDI--KEKISKGEYGN 365
++ + +++ S+ L + + +R+I +L++ ++ ++ + + + + E
Sbjct: 321 SVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAK 380
Query: 366 A-GIMAEVEELRKRVLDMEGKDEELIKME---EQCRDLNKRLERETLQSKDFKLEVEKLS 421
A + E+E+ + L +G D+ ++++E +Q R + + +RE ++ + +LE EK
Sbjct: 381 ATSHVGEIEQ--ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN-QLEEEK-- 435
Query: 422 KRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELE-------- 473
K+ED L+ +E+E +T L + + RIKELE
Sbjct: 436 ------RKVED-----------LQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKT 478
Query: 474 ---AIESRLEKTEF-TLKE-----DLTKLKTLTVMFVDERKTMSEKLKKTED-----KLQ 519
++ LE T T+ E +L K L V V E + E K D L
Sbjct: 479 KADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLL 538
Query: 520 AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEK----MYSVT----KERDDLKNKL 571
S LQ + T ++ I K ++ + +K +Y+ T KE + LK+KL
Sbjct: 539 QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 598
Query: 572 KAEEEKGNDLLSRVNMLKNRLQSLEAIEK---DFLKNKLNQDSGKSTTALHQENNKIKEL 628
+ ++ +D+++ + K++L++ A + + LK ++ G T + +I+++
Sbjct: 599 EHANKENSDVIA---LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKM 655
Query: 629 ----SQEVERLK--------LKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKE 676
E+E L+ K+M+A+ LMK E E ++ DKA+ +
Sbjct: 656 RLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAE----D 711
Query: 677 LEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLI 736
V+ME KL E + K L+ +AK ++ +D ++ ATE+ +
Sbjct: 712 QHLVEMEDTLNKLQE------AEIKVKELEVLQAKCNEQTKVIDNFTSQL---KATEEKL 762
Query: 737 CHLQGDHSVLQKKLNQQENRNRDLGREIENLTK-----ELERYRHFSK--SLRPSLNGRR 789
D L+K ++ ++ + L +++E K E+E+ SK S+ L GR
Sbjct: 763 L----DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818
Query: 790 I 790
+
Sbjct: 819 L 819
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,733,587
Number of Sequences: 37866
Number of extensions: 2089856
Number of successful extensions: 31366
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 540
Number of HSP's successfully gapped in prelim test: 1491
Number of HSP's that attempted gapping in prelim test: 10414
Number of HSP's gapped (non-prelim): 8581
length of query: 1135
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1022
effective length of database: 13,968,660
effective search space: 14275970520
effective search space used: 14275970520
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.