Search of human proteins with 142976729

Search of human proteins with 142976729

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
         (300 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]        591   e-169
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...   390   e-108
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...   326   2e-89
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]          238   6e-63
gi|223646115 short chain dehydrogenase/reductase family 16C, mem...   215   3e-56
gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                   212   4e-55
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ...   177   1e-44
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...   100   3e-21
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...   100   3e-21
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      92   6e-19
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       92   6e-19
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        89   5e-18
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    87   2e-17
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     82   8e-16
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    79   5e-15
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    78   8e-15
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    77   2e-14
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         76   3e-14
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    75   7e-14
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho...    75   9e-14
gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                   74   1e-13
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho...    74   2e-13
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    73   3e-13
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                   73   3e-13
gi|40254992 carbonic reductase 4 [Homo sapiens]                        70   2e-12
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...    70   3e-12
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          70   3e-12
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    69   4e-12
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            69   4e-12
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    69   5e-12

>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score =  591 bits (1524), Expect = e-169
 Identities = 300/300 (100%), Positives = 300/300 (100%)

Query: 1   MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60
           MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK
Sbjct: 1   MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60

Query: 61  SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN 120
           SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN
Sbjct: 61  SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN 120

Query: 121 AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP 180
           AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP
Sbjct: 121 AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP 180

Query: 181 FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE 240
           FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE
Sbjct: 181 FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE 240

Query: 241 EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMKAQ 300
           EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMKAQ
Sbjct: 241 EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMKAQ 300


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score =  390 bits (1001), Expect = e-108
 Identities = 190/298 (63%), Positives = 232/298 (77%)

Query: 1   MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60
           M  +L+ILLLL  +I   LES VK FIP+RRKSV GEIVLITGAGHGIGR T YEFAK +
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60

Query: 61  SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN 120
           S LVLWDINK G+EETAA+C+ LG   H +VVDCSNRE+IY S  +VK E+GDV+I+VNN
Sbjct: 61  SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN 120

Query: 121 AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP 180
           AG VY +DL +T+D +I KTFEVN+L HFW TKA LP+M + NHGHIVTVAS  GH  +P
Sbjct: 121 AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP 180

Query: 181 FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE 240
           +L+ YCSSKFAAVGFH+ LT EL AL  TG+KT+CLCP FVNTGF KNPST L P LE +
Sbjct: 181 YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD 240

Query: 241 EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMK 298
           EVV  L+ GILT +KMIF+PS I     L++ LPER  A+L +  +++F+AV+G+K+K
Sbjct: 241 EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIK 298


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score =  326 bits (835), Expect = 2e-89
 Identities = 169/298 (56%), Positives = 205/298 (68%), Gaps = 36/298 (12%)

Query: 1   MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60
           M  +L+ILLLL  +I   LES VK FIP+RRKSV GEIVLITGAGHGIGR T YEFAK +
Sbjct: 1   MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ 60

Query: 61  SKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNN 120
           S LVLWDINK                                    VK E+GDV+I+VNN
Sbjct: 61  SILVLWDINK------------------------------------VKKEVGDVTIVVNN 84

Query: 121 AGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVP 180
           AG VY +DL +T+D +I KTFEVN+L HFW TKA LP+M + NHGHIVTVAS  GH  +P
Sbjct: 85  AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP 144

Query: 181 FLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPE 240
           +L+ YCSSKFAAVGFH+ LT EL AL  TG+KT+CLCP FVNTGF KNPST L P LE +
Sbjct: 145 YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD 204

Query: 241 EVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMK 298
           EVV  L+ GILT +KMIF+PS I     L++ LPER  A+L +  +++F+AV+G+K+K
Sbjct: 205 EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIK 262


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score =  238 bits (606), Expect = 6e-63
 Identities = 124/260 (47%), Positives = 169/260 (65%), Gaps = 4/260 (1%)

Query: 19  LESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAA 78
           LE+ +   +PK RK+V GEIVLITGAG G+GRL A +FA+L S LVLWDINK G EET  
Sbjct: 23  LEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCK 82

Query: 79  KCKGLGA-KVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQI 137
             +  GA +VH +  DCS +E +Y  A +VK E+GDVSIL+NNAG+V         D  +
Sbjct: 83  MAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELM 142

Query: 138 EKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHK 197
           EK+F+VN  AH WT KAFLPAM  N+HGH+V ++S+AG   V  L  YC+SKFAA GF +
Sbjct: 143 EKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAE 202

Query: 198 TLTDELAALQITGVKTTCLCPNFVNTGFIKNPST---SLGPTLEPEEVVNRLMHGILTEQ 254
           ++  E    +  G+KTT +CP F+ TG  +  +T   SL P LEP+  V +++  IL E+
Sbjct: 203 SVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIVEAILQEK 262

Query: 255 KMIFIPSSIAFLTTLERILP 274
             +++P  + F+  L+  LP
Sbjct: 263 MYLYMPKLLYFMMFLKSFLP 282


>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score =  215 bits (548), Expect = 3e-56
 Identities = 127/299 (42%), Positives = 176/299 (58%), Gaps = 13/299 (4%)

Query: 1   MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60
           M  + D  +LL       LES V   IPK++K+V GEIVL TGAG G+GR  A  FA+  
Sbjct: 1   MDVIADTSVLLGKFPYYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFG 60

Query: 61  SKLVLWDINKHGLEETA--AKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILV 118
           + LVLWD+N+ G  ET   AK KG G KV  +  DCSNR+++Y  A +V+ E GDV+ILV
Sbjct: 61  AILVLWDVNQEGNMETCRLAKEKG-GKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILV 119

Query: 119 NNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVS 178
           NNA +V         D  +EK+F VN + HFWT KAFLPA+ K NHGH+V ++S AG V 
Sbjct: 120 NNADLVTGKPFLDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVG 179

Query: 179 VPFLL-------AYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPST 231
           +  L         Y +SKFAA GF ++L  EL  ++ T VK+T +CP+F+NTG  +  ++
Sbjct: 180 INGLSDEYFVSPYYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTS 239

Query: 232 S---LGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISV 287
               L P LE E V  ++++ IL EQ  + IP        L++I+  + L    + + V
Sbjct: 240 KYPFLLPILEQEYVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGV 298


>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score =  212 bits (539), Expect = 4e-55
 Identities = 119/275 (43%), Positives = 160/275 (58%), Gaps = 30/275 (10%)

Query: 30  RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGL------ 83
           + KSV G++ LITGAG G+GRL A EFA+ ++ LVLWDIN    EETA   + +      
Sbjct: 30  KEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEA 89

Query: 84  -------------------GAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVV 124
                                +V T+  D   RE++Y +A++V+ E+G+VS+LVNNAGVV
Sbjct: 90  ADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVV 149

Query: 125 YTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLA 184
               L    D  IE+T  VN  AHFWTTKAFLP M + NHGHIVTVAS+ G  S   +  
Sbjct: 150 SGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVED 209

Query: 185 YCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGF-----IKNPSTSLGPTLEP 239
           YC+SKF  VGFH++L+ EL A +  G+KTT +CP  V+TG      I+       P L+P
Sbjct: 210 YCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKP 269

Query: 240 EEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILP 274
           +  V + M  ILT+Q MI  P  +  +T ++ ILP
Sbjct: 270 DYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILP 304


>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
           sapiens]
          Length = 302

 Score =  177 bits (448), Expect = 1e-44
 Identities = 102/279 (36%), Positives = 160/279 (57%), Gaps = 7/279 (2%)

Query: 5   LDILLLLPL-LIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKS-K 62
           L  L++ PL +I   +++ V L +P + + ++ E VLITG G GIGR  A EFA+  + K
Sbjct: 6   LGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARK 65

Query: 63  LVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAG 122
           +VLW   +  L+ET  + + +G + H F+ D  NRE++Y +AK V+ ++GD++ILVNNA 
Sbjct: 66  IVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAA 125

Query: 123 VVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFL 182
           VV+   L  + D  + K+  +N L  FWTTKAFLP M +  +GHIV + S     ++P  
Sbjct: 126 VVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGA 185

Query: 183 LAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPST---SLGPTLEP 239
           + YC+SK +A  F ++LT  L  L   GV  T + P   +T   +       +L P L+P
Sbjct: 186 IDYCTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKP 243

Query: 240 EEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFL 278
           E V  R +  +   Q ++ +P ++  L  L+ ILP+  L
Sbjct: 244 ETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAAL 282


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 68/199 (34%), Positives = 93/199 (46%), Gaps = 6/199 (3%)

Query: 34  VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLG----AKVHT 89
           +T  +V +TGA  GIG   AY+ +KL   LVL     H LE    +C   G      +  
Sbjct: 48  LTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILV 107

Query: 90  FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHF 149
             +D ++     ++ K V  E G + ILVNN G+   S    T      K  E+N L   
Sbjct: 108 LPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTV 167

Query: 150 WTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQIT 209
             TK  LP M +   G IVTV S  G +SVP  + YC+SK A  GF   L  ELA     
Sbjct: 168 SLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELAT--YP 225

Query: 210 GVKTTCLCPNFVNTGFIKN 228
           G+  + +CP  V +  ++N
Sbjct: 226 GIIVSNICPGPVQSNIVEN 244


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 83/283 (29%), Positives = 127/283 (44%), Gaps = 26/283 (9%)

Query: 10  LLPLLIVC-SLESFVKLFIPKRRKS-VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWD 67
           +LPLL  C  +    +L    R K+ +   +V+ITGA  G+G+  A  F    +KLVL  
Sbjct: 24  ILPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCG 83

Query: 68  INKHGLEETAAKCKGLGA------KVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNA 121
            N   LEE   +     A      K +    D ++   I ++A ++    G V ILVNNA
Sbjct: 84  RNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNA 143

Query: 122 GVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPF 181
           G+ Y   +  T     ++  E N       TKA LP+M K   GHIV ++S  G +S+PF
Sbjct: 144 GISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPF 203

Query: 182 LLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTL---- 237
             AY +SK A   F   L  E+   +I   + T + P +++T    N  T+ G       
Sbjct: 204 RSAYAASKHATQAFFDCLRAEMEQYEI---EVTVISPGYIHTNLSVNAITADGSRYGVMD 260

Query: 238 -------EPEEVVNRLMHGILTEQKMI----FIPSSIAFLTTL 269
                   P EV   ++  +  ++K +     +PS   +L TL
Sbjct: 261 TTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTL 303


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 78/268 (29%), Positives = 129/268 (48%), Gaps = 17/268 (6%)

Query: 2   KFLLDIL-LLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60
           K+LL IL L +      + E F       R + + G+ V++TGA  GIGR  AY  AK+ 
Sbjct: 6   KYLLPILGLFMAYYYYSANEEF-------RPEMLQGKKVIVTGASKGIGREMAYHLAKMG 58

Query: 61  SKLVLWDINKHGLEETAAKCKGLGAKVHTFVV----DCSNREDIYSSAKKVKAEIGDVSI 116
           + +V+   +K  L++  + C  LGA    ++     D +  E   + A K+   +G + +
Sbjct: 59  AHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKL---MGGLDM 115

Query: 117 LVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGH 176
           L+ N     + +LF      + K+ EVN L++   T A LP M K ++G IV V+S AG 
Sbjct: 116 LILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGK 174

Query: 177 VSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPT 236
           V+ P + AY +SKFA  GF  ++  E +  ++    T C+         +K  S  +   
Sbjct: 175 VAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQ 234

Query: 237 LEP-EEVVNRLMHGILTEQKMIFIPSSI 263
             P EE    ++ G    Q+ ++  SS+
Sbjct: 235 AAPKEECALEIIKGGALRQEEVYYDSSL 262


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 78/268 (29%), Positives = 129/268 (48%), Gaps = 17/268 (6%)

Query: 2   KFLLDIL-LLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLK 60
           K+LL IL L +      + E F       R + + G+ V++TGA  GIGR  AY  AK+ 
Sbjct: 6   KYLLPILGLFMAYYYYSANEEF-------RPEMLQGKKVIVTGASKGIGREMAYHLAKMG 58

Query: 61  SKLVLWDINKHGLEETAAKCKGLGAKVHTFVV----DCSNREDIYSSAKKVKAEIGDVSI 116
           + +V+   +K  L++  + C  LGA    ++     D +  E   + A K+   +G + +
Sbjct: 59  AHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKL---MGGLDM 115

Query: 117 LVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGH 176
           L+ N     + +LF      + K+ EVN L++   T A LP M K ++G IV V+S AG 
Sbjct: 116 LILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGK 174

Query: 177 VSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPT 236
           V+ P + AY +SKFA  GF  ++  E +  ++    T C+         +K  S  +   
Sbjct: 175 VAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQ 234

Query: 237 LEP-EEVVNRLMHGILTEQKMIFIPSSI 263
             P EE    ++ G    Q+ ++  SS+
Sbjct: 235 AAPKEECALEIIKGGALRQEEVYYDSSL 262


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 68/231 (29%), Positives = 107/231 (46%), Gaps = 17/231 (7%)

Query: 38  IVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLG--AKVHTFVVDCS 95
           + L+TGA  GIG   A    +   K+V        +EE AA+CK  G    +  +  D S
Sbjct: 13  LALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLS 72

Query: 96  NREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAF 155
           N EDI S    ++++   V I +NNAG+     L +      +  F VNVLA    T+  
Sbjct: 73  NEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREA 132

Query: 156 LPAMTKNN--HGHIVTVASAAGHVSVPFLLA--YCSSKFAAVGFHKTLTDELAALQITGV 211
             +M + N   GHI+ + S +GH  +P  +   Y ++K+A     + L  EL   Q T +
Sbjct: 133 YQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQ-THI 191

Query: 212 KTTCLCPNFVNTGFI-----KNPSTSLG-----PTLEPEEVVNRLMHGILT 252
           + TC+ P  V T F      K+P  +         L+PE+V   +++ + T
Sbjct: 192 RATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLST 242


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 71/228 (31%), Positives = 118/228 (51%), Gaps = 20/228 (8%)

Query: 34  VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDIN-KHGLEETAAKCKGLGAKVHTFV- 91
           V G++ L+TGA  GIGR  A       +K+ L D N + G++  AA  +    +   F+ 
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62

Query: 92  VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151
            D ++++ +  + +KV    G + ILVNNAGV          +   EKT ++N+++    
Sbjct: 63  CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVISG 114

Query: 152 TKAFLPAMTKNNHGH---IVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAA-LQ 207
           T   L  M+K N G    I+ ++S AG + V     YC+SK   VGF  T +  LAA L 
Sbjct: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGF--TRSAALAANLM 172

Query: 208 ITGVKTTCLCPNFVNTGFIKN--PSTSLGPTLEPEEVVNRLM--HGIL 251
            +GV+   +CP FVNT  +++     ++G  +E ++ +  ++  +GIL
Sbjct: 173 NSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGIL 220


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 58/210 (27%), Positives = 105/210 (50%), Gaps = 16/210 (7%)

Query: 36  GEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCS 95
           G+++++T A  GIG+  A  FA+  +K++  DIN+  L+E   K  G    + T V+D +
Sbjct: 6   GKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKLQELE-KYPG----IQTRVLDVT 60

Query: 96  NREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAF 155
            ++ I   A +V+     + +L N AG V+   +   ++   + +  +NV + +   KAF
Sbjct: 61  KKKQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAF 116

Query: 156 LPAMTKNNHGHIVTVASAAGHV-SVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTT 214
           LP M     G+I+ ++S A  V  V     Y ++K A +G  K++  +       G++  
Sbjct: 117 LPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ---QGIRCN 173

Query: 215 CLCPNFVNTGFIKNPSTSLGPTLEPEEVVN 244
           C+CP  V+T  ++    + G    PEE  N
Sbjct: 174 CVCPGTVDTPSLQERIQARG---NPEEARN 200


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 79.0 bits (193), Expect = 5e-15
 Identities = 61/197 (30%), Positives = 98/197 (49%), Gaps = 10/197 (5%)

Query: 36  GEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKG-LGAKVHTFVVDC 94
           GE  ++TG+  GIG+  A E AK   K+VL   +K  L++ +++ K     +  T  VD 
Sbjct: 50  GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109

Query: 95  SNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQ----IEKTFEVNVLAHFW 150
           ++ EDIY   K   A + ++ ILVNN G+ Y    +    P     I+K   +N+L+   
Sbjct: 110 AS-EDIYDKIKTGLAGL-EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167

Query: 151 TTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITG 210
            T+  LP M + + G I+ ++S +G + VP L  Y ++K     F + L +E  +    G
Sbjct: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS---KG 224

Query: 211 VKTTCLCPNFVNTGFIK 227
           V    + P FV T   K
Sbjct: 225 VFVQSVLPYFVATKLAK 241


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 78.2 bits (191), Expect = 8e-15
 Identities = 59/200 (29%), Positives = 92/200 (46%), Gaps = 10/200 (5%)

Query: 30  RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHT 89
           RR  +  ++ L+T +  GIG   A   A+  + +V+    +  +++  A  +G G  V  
Sbjct: 26  RRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85

Query: 90  FVVDCSNRED---IYSSAKKVKAEIGDVSILVNNAGV-VYTSDLFATQDPQIEKTFEVNV 145
            V      ED   + ++A K+    G + ILV+NA V  +   +    +   +KT ++NV
Sbjct: 86  TVCHVGKAEDRERLVATAVKLH---GGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142

Query: 146 LAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAA 205
            A    TKA +P M K   G +V V+S A     P    Y  SK A +G  KTL  ELA 
Sbjct: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202

Query: 206 LQITGVKTTCLCPNFVNTGF 225
                ++  CL P  + T F
Sbjct: 203 ---RNIRVNCLAPGLIKTSF 219


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 79/276 (28%), Positives = 120/276 (43%), Gaps = 40/276 (14%)

Query: 38  IVLITGAGHGIG-----RLTAYEFAKLKSKLVLWDINKHG-LEETAAKCKGLGAKVHTFV 91
           +VLITG   GIG     RL +      K    L D+   G L E A         + T  
Sbjct: 5   VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64

Query: 92  VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151
           +D  + + + ++ ++V    G V +LV NAG+     L A  +  +    +VNV+     
Sbjct: 65  LDVRDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122

Query: 152 TKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQIT-G 210
            +AFLP M +   G ++   S  G + +PF   YC+SKFA  G    L + LA L +  G
Sbjct: 123 LQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEG----LCESLAVLLLPFG 178

Query: 211 VKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRL-------MHGILTEQKMIF----- 258
           V  + +    V+T F++    S      PEEV++R         +  L   K +F     
Sbjct: 179 VHLSLIECGPVHTAFMEKVLGS------PEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQ 232

Query: 259 IPSSIA--FLT-------TLERILPERFLAVLKQKI 285
            P  +A  FLT       TL     ERFL +L+ ++
Sbjct: 233 NPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRL 268


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 69/228 (30%), Positives = 101/228 (44%), Gaps = 28/228 (12%)

Query: 31  RKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKG--LGAKVH 88
           + ++ G+ V++TGA  GIG+ TA E A+    ++L   +    E  A   +G  L   V+
Sbjct: 33  KATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVN 92

Query: 89  TFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAH 148
              +D ++ + I   A K+  E   V IL+NNAGV+       T +   E  F VN L H
Sbjct: 93  ARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHW--TTEDGFEMQFGVNHLGH 150

Query: 149 FWTTKAFLPAMTKNNHGHIVTVAS---AAGHVSVPFL----------LAYCSSKFAAVGF 195
           F  T   L  +  +    I+ ++S    AGH+    L           AYC SK A V F
Sbjct: 151 FLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLF 210

Query: 196 HKTLTDELAALQITGVKTTCLCPNFVNTGFIKN--------PSTSLGP 235
            K L+     LQ +GV    L P    T   ++         ST+LGP
Sbjct: 211 TKELS---RRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGP 255


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 75.1 bits (183), Expect = 7e-14
 Identities = 80/309 (25%), Positives = 130/309 (42%), Gaps = 36/309 (11%)

Query: 8   LLLLPLLIVCSLESFVKLFIPKRR----KSVTGEIVLITGAGHGIGRLTAYEFAKLKSKL 63
           +L+LPLL++  +   + ++    R     +V  ++V+IT A  G+G+  A  F    ++L
Sbjct: 6   MLMLPLLLL-GISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARL 64

Query: 64  VLWDINKHGLEETAAKCKGLGAKVHTF-----VVDCSNREDIYSSAKKVKAEIGDVSILV 118
           VL   N   LE        +     TF     ++D S+   +   AK+V    G V IL+
Sbjct: 65  VLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDILI 124

Query: 119 NNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVS 178
           NNA V              +K  + N       TKA LP M     G IV V +  G   
Sbjct: 125 NNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFG 184

Query: 179 VPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFI------------ 226
           +PF   Y +SK AA+GF   L  E+    +     + + P F+ +  +            
Sbjct: 185 IPFRTTYAASKHAALGFFDCLRAEVEEYDVV---ISTVSPTFIRSYHVYPEQGNWEASIW 241

Query: 227 KNPSTSLGPTLEPEEVVNRLMHGILTEQKMIF----IPSSIAFLTTLERILPERFLAV-- 280
           K     L   + P EV   +M  +  +++ +F    IP +  ++ T     PE F AV  
Sbjct: 242 KFFFRKLTYGVHPVEVAEEVMRTVRRKKQEVFMANPIPKAAVYVRT---FFPEFFFAVVA 298

Query: 281 --LKQKISV 287
             +K+K++V
Sbjct: 299 CGVKEKLNV 307


>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
           sapiens]
          Length = 286

 Score = 74.7 bits (182), Expect = 9e-14
 Identities = 69/258 (26%), Positives = 113/258 (43%), Gaps = 5/258 (1%)

Query: 33  SVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGA-KVHTFV 91
           S+ G  VL+TGA  G+G   AY +A+L S LVL    +  L++    C+ LGA KV    
Sbjct: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85

Query: 92  VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151
            D ++ E   S  +    ++G +  LV N      +   A          +VN +++   
Sbjct: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQL 145

Query: 152 TKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGV 211
           T   LP++T ++ G +V V+S  G V   F   Y ++KFA  GF  +L  EL    +   
Sbjct: 146 TSRALPSLT-DSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVA 204

Query: 212 KTTCL--CPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTL 269
            T C+    +  +        T +     P+  +  ++ G  T    +F P     L  L
Sbjct: 205 ITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAAL-AVIRGGATRAAGVFYPWRFRLLCLL 263

Query: 270 ERILPERFLAVLKQKISV 287
            R LP      ++Q+++V
Sbjct: 264 RRWLPRPRAWFIRQELNV 281


>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 73/248 (29%), Positives = 114/248 (45%), Gaps = 32/248 (12%)

Query: 9   LLLPLLIVCSLESFVKLFIPKRRK-----------SVTGEIVLITGAGHGIGRLTAYEFA 57
           +L+ L ++ S  SF+ +  P  RK            + G++V+ITGA  GIG+ TA E A
Sbjct: 1   MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELA 60

Query: 58  KLKSKLVL--WDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVS 115
              +++ +   D+ K     +  +     ++V    +D S+ + I + A+   AE   + 
Sbjct: 61  SRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLH 120

Query: 116 ILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAG 175
           IL+NNAGV+     ++      E    VN L HF  T   L  +  +    +V V+S A 
Sbjct: 121 ILINNAGVMMCP--YSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAH 178

Query: 176 HV-SVPFL-----------LAYCSSKFAAVGFHKTLTDELA-ALQITGVKTTCLCPNFVN 222
           H+  +PF             AYC SK A V F    T ELA  LQ TGV T  + P  V 
Sbjct: 179 HIGKIPFHDLQSEKRYSRGFAYCHSKLANVLF----TRELAKRLQGTGVTTYAVHPGVVR 234

Query: 223 TGFIKNPS 230
           +  +++ S
Sbjct: 235 SELVRHSS 242


>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
           sapiens]
          Length = 315

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 66/239 (27%), Positives = 105/239 (43%), Gaps = 9/239 (3%)

Query: 33  SVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGA-KVHTFV 91
           S+ G  VL+TGA  G+G   AY +A+L S LVL    +  L++    C+ LGA KV    
Sbjct: 26  SLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIA 85

Query: 92  VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151
            D ++ E   S  +    ++G +  LV N      +   A          +VN +++   
Sbjct: 86  ADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQL 145

Query: 152 TKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGV 211
           T   LP++T ++ G +V V+S  G V   F   Y ++KFA  GF  +L  EL    +   
Sbjct: 146 TSRALPSLT-DSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVA 204

Query: 212 KTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGI-LTEQKMIFIPSSIAFLTTL 269
            T C+          +   +S     +PE        G+ L  Q  +F+P ++    TL
Sbjct: 205 ITMCVLGLRDRASAAEAVRSSTSRPRQPEH------RGVPLQSQTAMFLPPTVPGARTL 257


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 55/188 (29%), Positives = 84/188 (44%), Gaps = 4/188 (2%)

Query: 30  RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHT 89
           RR  +T ++ L+T +  GIG   A   A+ ++ +V+    +  +++  A  +G G  V  
Sbjct: 26  RRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATLQGEGLSVTG 85

Query: 90  FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGV-VYTSDLFATQDPQIEKTFEVNVLAH 148
            V      ED            G + ILV+NA V  +   L    +   +KT ++NV A 
Sbjct: 86  TVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAP 145

Query: 149 FWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQI 208
              TKA +P M K   G +V V+S A     P    Y  SK A +G + TL  ELA    
Sbjct: 146 ALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAP--- 202

Query: 209 TGVKTTCL 216
             ++  CL
Sbjct: 203 RNIRVNCL 210


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score = 72.8 bits (177), Expect = 3e-13
 Identities = 70/242 (28%), Positives = 111/242 (45%), Gaps = 24/242 (9%)

Query: 7   ILLLLPLLIVCSLESFVKLF---IPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKL 63
           +LLLLP L+  +     K+    +      + G++V++TGA  GIG+ TA E A+  +++
Sbjct: 9   LLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARV 68

Query: 64  VL--WDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNA 121
            L   D+ K  L     +      +V    +D S+ + I + AK   AE   + +L+NNA
Sbjct: 69  YLACRDVEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNA 128

Query: 122 GVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPF 181
           GV+     ++      E    VN L HF  T   L  + ++    IV V+S A H+    
Sbjct: 129 GVMMCP--YSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIH 186

Query: 182 L------------LAYCSSKFAAVGFHKTLTDELA-ALQITGVKTTCLCPNFVNTGFIKN 228
                        LAYC SK A + F    T ELA  L+ +GV T  + P  V +  +++
Sbjct: 187 FHNLQGEKFYNAGLAYCHSKLANILF----TQELARRLKGSGVTTYSVHPGTVQSELVRH 242

Query: 229 PS 230
            S
Sbjct: 243 SS 244


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 52/192 (27%), Positives = 83/192 (43%), Gaps = 6/192 (3%)

Query: 37  EIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSN 96
           ++  + G   GIGR  A   A+   +L +   N  G +  A     LG     F  D + 
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGD---LGGDHLAFSCDVAK 59

Query: 97  REDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFL 156
             D+ ++ ++++  +G V+ LVN AG+     L  T+   +      N+L    T KA +
Sbjct: 60  EHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAM 119

Query: 157 PAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCL 216
             M +   G IV V S  G         Y +SK   VGF + L  E+A  +I   +   +
Sbjct: 120 RTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKI---RVNVV 176

Query: 217 CPNFVNTGFIKN 228
            P FV+T   K+
Sbjct: 177 APGFVHTDMTKD 188


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 65/221 (29%), Positives = 99/221 (44%), Gaps = 15/221 (6%)

Query: 13  LLIVCSLESFVKL-FIPKRRKSVT-----GEIVLITGAGHGIGRLTAYEFAKLKSKLVLW 66
           + ++C   S ++L FIP+           G   +++GA  GIG+  A E A     ++L 
Sbjct: 38  ITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILI 97

Query: 67  DINKHGLEETAAKCKGLGAKVHT--FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVV 124
             N+  L+   AK      KV T   V D S+  +IY   ++   +  DV ILVNN GV 
Sbjct: 98  SRNEEKLQ-VVAKDIADTYKVETDIIVADFSSGREIYLPIREALKD-KDVGILVNNVGVF 155

Query: 125 YTSDLFATQ--DPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFL 182
           Y    + TQ  + ++     VN+ A        LP M +   G IVT++S +     P L
Sbjct: 156 YPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQL 215

Query: 183 LAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNT 223
            A+ +SK     F + L  E A+    G+    L P +V T
Sbjct: 216 AAFSASKAYLDHFSRALQYEYAS---KGIFVQSLIPFYVAT 253


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 54/174 (31%), Positives = 79/174 (45%), Gaps = 7/174 (4%)

Query: 39  VLITGAGHGIGRLTAYEFAKLKSKL--VLWDINKHGLEET--AAKCKGLGAKVHTFVVDC 94
           VLI+G   GIG   A + A    K   V+  +   G +ET  AA  + LG  +    +D 
Sbjct: 8   VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDV 67

Query: 95  SNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKA 154
            + E +      ++   G+V +LVNNAG+     L       ++  F+ N        KA
Sbjct: 68  CSDESVAQCLSCIQ---GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKA 124

Query: 155 FLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQI 208
            LP M +   GHIV ++S  G   V F   Y +SKFA  GF ++L  +L    I
Sbjct: 125 VLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNI 178


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 53/170 (31%), Positives = 86/170 (50%), Gaps = 13/170 (7%)

Query: 34  VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDIN-KHGLEETAAKCKGLGAKVHTFV- 91
           V G++ L+TGA  GIGR  A       +K+ L D N + G++  AA  +    +   F+ 
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62

Query: 92  VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151
            D ++++ +  + +KV    G + ILVNNAGV          +   EKT ++N+++    
Sbjct: 63  CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVISG 114

Query: 152 TKAFLPAMTKNNHGH---IVTVASAAGHVSVPFLLAYCSSKFAAVGFHKT 198
           T   L  M+K N G    I+ ++S AG + V     YC+SK   VGF ++
Sbjct: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRS 164


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 70/284 (24%), Positives = 116/284 (40%), Gaps = 15/284 (5%)

Query: 17  CSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEET 76
           C L ++ K+ +PK      G+  +ITGAG GIG+  ++E AK    +VL       LE  
Sbjct: 30  CVLLNYWKV-LPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAI 88

Query: 77  AAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVV--YTSDLFATQD 134
           A + +    +    +     ++DIY   K+  A + ++ ILVNN G++       F    
Sbjct: 89  ATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGL-EIGILVNNVGMLPNLLPSHFLNAP 147

Query: 135 PQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVG 194
            +I+     N+ +    T+  L  M     G I+ ++S       P    Y +SK     
Sbjct: 148 DEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCA 207

Query: 195 FHKTLTDELAALQI-----TGVKTTCLCPNFVNTGFIKNPS-----TSLGPTLEPEEVVN 244
           F K L +E  A ++     T    +     ++NT  I   +      SL       E   
Sbjct: 208 FSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCG 267

Query: 245 RLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVK 288
            L H IL    +  IP+   +    +R+L   ++A LK    V+
Sbjct: 268 CLAHEILA-GFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR 310


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 56/199 (28%), Positives = 84/199 (42%), Gaps = 5/199 (2%)

Query: 30  RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHT 89
           R+  +   + ++TG+  GIG   A   A+  + +V+    +  ++   AK +G G  V  
Sbjct: 30  RKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAG 89

Query: 90  FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGV-VYTSDLFATQDPQIEKTFEVNVLAH 148
            V      ED      K     G V  LV +AGV         T +   +K   VNV + 
Sbjct: 90  IVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSP 149

Query: 149 FWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQI 208
                  LP M +N  G ++ V+S A +  V  L  Y  SK A +G  +TL  ELA   I
Sbjct: 150 ALLLSQLLPYM-ENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDI 208

Query: 209 TGVKTTCLCPNFVNTGFIK 227
              +  C+ P  + T F K
Sbjct: 209 ---RVNCVVPGIIKTDFSK 224


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,776,199
Number of Sequences: 37866
Number of extensions: 381585
Number of successful extensions: 1028
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 907
Number of HSP's gapped (non-prelim): 75
length of query: 300
length of database: 18,247,518
effective HSP length: 102
effective length of query: 198
effective length of database: 14,385,186
effective search space: 2848266828
effective search space used: 2848266828
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.