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Search of human proteins with 9961252
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform
C [Homo sapiens]
(1232 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 2394 0.0
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 2371 0.0
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 2364 0.0
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 1810 0.0
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 1193 0.0
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 887 0.0
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 349 1e-95
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 318 2e-86
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 314 3e-85
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 314 3e-85
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 298 2e-80
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 258 3e-68
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 243 6e-64
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 238 2e-62
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 236 1e-61
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 223 7e-58
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 223 9e-58
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 202 1e-51
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 200 6e-51
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 149 1e-35
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 145 3e-34
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 145 3e-34
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 144 4e-34
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 144 4e-34
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 144 4e-34
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 144 4e-34
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 143 9e-34
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 140 6e-33
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 140 6e-33
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 140 6e-33
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 2394 bits (6203), Expect = 0.0
Identities = 1232/1232 (100%), Positives = 1232/1232 (100%)
Query: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
Query: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
Query: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
Query: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
Query: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
Query: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
Query: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
Query: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
Query: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 960
ENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL
Sbjct: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHL 960
Query: 961 FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL 1020
FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL
Sbjct: 961 FMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLAL 1020
Query: 1021 VGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1080
VGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA
Sbjct: 1021 VGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIA 1080
Query: 1081 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1140
ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR
Sbjct: 1081 ENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIAR 1140
Query: 1141 ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQN 1200
ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQN
Sbjct: 1141 ALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQN 1200
Query: 1201 GRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL 1232
GRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL
Sbjct: 1201 GRVKEHGTHQQLLAQKGIYFSMVSVQAGTQNL 1232
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 2371 bits (6145), Expect = 0.0
Identities = 1232/1279 (96%), Positives = 1232/1279 (96%), Gaps = 47/1279 (3%)
Query: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
Query: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
Query: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
Query: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
Query: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
Query: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
Query: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
Query: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
Query: 901 ENIRTVVSLTQERKFESMYVEKLYGPYR-------------------------------- 928
ENIRTVVSLTQERKFESMYVEKLYGPYR
Sbjct: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
Query: 929 ---------------VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 973
VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY
Sbjct: 961 YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
Query: 974 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1033
SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Sbjct: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
Query: 1034 LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS 1093
LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS
Sbjct: 1081 LLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS 1140
Query: 1094 QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE 1153
QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE
Sbjct: 1141 QDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDE 1200
Query: 1154 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1213
ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL
Sbjct: 1201 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1260
Query: 1214 AQKGIYFSMVSVQAGTQNL 1232
AQKGIYFSMVSVQAGTQNL
Sbjct: 1261 AQKGIYFSMVSVQAGTQNL 1279
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 2364 bits (6127), Expect = 0.0
Identities = 1232/1286 (95%), Positives = 1232/1286 (95%), Gaps = 54/1286 (4%)
Query: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYY 120
Query: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD
Sbjct: 121 SGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDD 180
Query: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA
Sbjct: 181 ISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSA 240
Query: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS
Sbjct: 241 FSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANIS 300
Query: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA
Sbjct: 301 MGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
Query: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ
Sbjct: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
Query: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV
Sbjct: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
Query: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR
Sbjct: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
Query: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI
Sbjct: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
Query: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS
Sbjct: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKS 660
Query: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA
Sbjct: 661 RLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIA 720
Query: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG
Sbjct: 721 NGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAG 780
Query: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA
Sbjct: 781 EILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIA 840
Query: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI
Sbjct: 841 NLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAI 900
Query: 901 ENIRTVVSLTQERKFESMYVEKLYGPYR-------------------------------- 928
ENIRTVVSLTQERKFESMYVEKLYGPYR
Sbjct: 901 ENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGA 960
Query: 929 ---------------VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 973
VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY
Sbjct: 961 YLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSY 1020
Query: 974 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1033
SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ
Sbjct: 1021 SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1080
Query: 1034 LLERFYDPLAGTV-------LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1086
LLERFYDPLAGTV LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG
Sbjct: 1081 LLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1140
Query: 1087 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1146
DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP
Sbjct: 1141 DNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQP 1200
Query: 1147 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1206
QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH
Sbjct: 1201 QILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEH 1260
Query: 1207 GTHQQLLAQKGIYFSMVSVQAGTQNL 1232
GTHQQLLAQKGIYFSMVSVQAGTQNL
Sbjct: 1261 GTHQQLLAQKGIYFSMVSVQAGTQNL 1286
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 1810 bits (4687), Expect = 0.0
Identities = 944/1289 (73%), Positives = 1077/1289 (83%), Gaps = 70/1289 (5%)
Query: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
MDLE +NG A + + F+L S++ +K+ K + V ++FRYS+W DKL+M +G
Sbjct: 1 MDLEGDRNGGAKK----KNFFKLNNKSEKDKKEKKPT--VSVFSMFRYSNWLDKLYMVVG 54
Query: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKI--------LEEE 112
T+ AI HG+GLPLMM+VFGEMTD F + AGN + ++ N I LEE+
Sbjct: 55 TLAAIIHGAGLPLMMLVFGEMTDIFAN-AGNLE---DLMSNITNRSDINDTGFFMNLEED 110
Query: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
MTRYAYYYSG+GAGVLVAAYIQVSFW LAAGRQI KIR++FFHAI+RQEIGWFD++D E
Sbjct: 111 MTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGE 170
Query: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
LNTRLTDD+SKI+EGIGDK+GMFFQ++ATFF GFIVGF RGWKLTLVI+AISP+LGLSAA
Sbjct: 171 LNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAA 230
Query: 233 VWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIK 292
VWAKILS+F+DKEL AYAKAGAVAEE L AIRTVIAFGGQ KELERY K+LE AK IGIK
Sbjct: 231 VWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIK 290
Query: 293 KAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAP 352
KAI+ANIS+G AFLLIYASYALAFWYG+TLV+S EY+IG +TVFFS+LIGAFSVGQA+P
Sbjct: 291 KAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
Query: 353 CIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKIL 412
I+AFANARGAAY IF IIDN P IDS+S+ GHKPD+IKGNLEF +VHFSYPSR VKIL
Sbjct: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKIL 410
Query: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
KGLNLKVQSGQTVALVG+SGCGKSTTVQL+QRLYDP EG +++DGQDIR NV +LREII
Sbjct: 411 KGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREII 470
Query: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQ 532
GVVSQEPVLF+TTIAENI YGR NVTMDEI+KAVKEANAY+FIMKLP KFDTLVGERGAQ
Sbjct: 471 GVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQ 530
Query: 533 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLS 592
LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA VQ ALDKAR+GRTTIVIAHRLS
Sbjct: 531 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLS 590
Query: 593 TVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEF--ELNDEKAA 650
TVRNADVIAGF+DGVIVE+G+H ELMK++G+YFKLV MQT+G++++ E E E A
Sbjct: 591 TVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDA 650
Query: 651 TRMAPNGWKSRLFR-HSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWP 709
M+ N +S L R ST+++++ SQ + L + + L+ ++PPVSF +++KLN TEWP
Sbjct: 651 LEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK-EALDESIPPVSFWRIMKLNLTEWP 709
Query: 710 YFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDD-AVKQQKCNIFSLIFLFLGIISFFT 768
YFVVG CAI NGGLQPAF++IFS+II +F DD K+Q N+FSL+FL LGIISF T
Sbjct: 710 YFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769
Query: 769 FFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGAT 828
FFLQGFTFGKAGEILT+RLR M F++MLRQD+SWFDD KN+TGAL+TRLA DAAQV+GA
Sbjct: 770 FFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAI 829
Query: 829 GTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKE 888
G+RLA+I QNIANLGTGIIISFIYGWQLTLLLLA+VPIIA++G+VEMK+L+G A +DKKE
Sbjct: 830 GSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE 889
Query: 889 LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR-------------------- 928
LE +GKIATEAIEN RTVVSLTQE+KFE MY + L PYR
Sbjct: 890 LEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMM 949
Query: 929 ---------------------------VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 961
VFSA+VFGA+A+G SSFAPDYAKAK+SAAH+
Sbjct: 950 YFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHII 1009
Query: 962 MLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1021
M+ E+ PLIDSYS EGL P+ EGN+TF EVVFNYPTR ++PVLQGLSLEVKKGQTLALV
Sbjct: 1010 MIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALV 1069
Query: 1022 GSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1081
GSSGCGKSTVVQLLERFYDPLAG VLLDG+E K+LNVQWLRA LGIVSQEPILFDCSIAE
Sbjct: 1070 GSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAE 1129
Query: 1082 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1141
NIAYGDNSRVVSQ+EIV AAK ANIH FIE+LP+KY T+VGDKGTQLSGGQKQRIAIARA
Sbjct: 1130 NIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARA 1189
Query: 1142 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1201
L+RQP ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG
Sbjct: 1190 LVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1249
Query: 1202 RVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
RVKEHGTHQQLLAQKGIYFSMVSVQAGT+
Sbjct: 1250 RVKEHGTHQQLLAQKGIYFSMVSVQAGTK 1278
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 1193 bits (3086), Expect = 0.0
Identities = 634/1293 (49%), Positives = 851/1293 (65%), Gaps = 103/1293 (7%)
Query: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
S Q KK V+ +G LFR+S D M +G++ A HG P ++++FG MTD F
Sbjct: 32 SRLQDEKKGDGVR-VGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGTMTDVF 90
Query: 86 VD--------------TAGNFSFPVNFSLS----------LLNPGKILEEEMTRYAYYYS 121
+D N N SL+ LLN +E EM ++A YY+
Sbjct: 91 IDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLN----IESEMIKFASYYA 146
Query: 122 GLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDI 181
G+ VL+ YIQ+ FW +AA RQI+K+R+ +F I+R EIGWFD N ELNTR +DDI
Sbjct: 147 GIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDI 206
Query: 182 SKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAF 241
+KI++ I D++ +F Q + + GF++GF RGWKLTLVI+++SP++G+ AA +S F
Sbjct: 207 NKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKF 266
Query: 242 SDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISM 301
+D EL AYAKAG VA+E + ++RTV AFGG+ +E+ERY+K+L A+ GI+K I
Sbjct: 267 TDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFT 326
Query: 302 GIAFLLIYASYALAFWYGSTLVISK-EYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANA 360
G + LI+ YALAFWYGSTLV+ + EYT G + +F S+++GA ++G A+PC++AFA
Sbjct: 327 GFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATG 386
Query: 361 RGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQ 420
R AA IF+ ID P ID SE G+K D IKG +EF++V F YPSR VKIL LN+ ++
Sbjct: 387 RAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIK 446
Query: 421 SGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPV 480
G+ ALVG SG GKST +QLIQR YDP EG + +DG DIR+ N+ +LR+ IG+V QEPV
Sbjct: 447 PGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPV 506
Query: 481 LFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQR 540
LFSTTIAENI YGR + TM++I +A KEANAY FIM LPQ+FDTLVGE G Q+SGGQKQR
Sbjct: 507 LFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQR 566
Query: 541 IAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVI 600
+AIARAL+RNPKILLLD ATSALD ESEA VQ L K + G T I +AHRLSTVR AD I
Sbjct: 567 VAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTI 626
Query: 601 AGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATR--MAPNGW 658
GFE G VE+G+H EL++++GVYF LV +Q+ G+Q +EE D K AT M +
Sbjct: 627 IGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEE----DIKDATEDDMLARTF 682
Query: 659 KSRLFRHSTQKNLKNSQMCQKSLDV--------------ETDGLEANVP------PVSFL 698
++ S + +++ Q S V E D + ++P P
Sbjct: 683 SRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVR 742
Query: 699 KVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIF 758
++LK + EWPY +VG+V A NG + P ++ +FS+I+ F D ++ + N L+F
Sbjct: 743 RILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLF 802
Query: 759 LFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLA 818
+ +G +S FT FLQG+ F K+GE+LT+RLR F+AML QD++WFDD +NS GAL+TRLA
Sbjct: 803 VAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLA 862
Query: 819 TDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLL 878
TDA+QVQGA G+++ +I + N+ +II+F + W+L+L++L P +A+SG + ++L
Sbjct: 863 TDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRML 922
Query: 879 AGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKF-ESMYVE------------KLYG 925
G A RDK+ LE G+I EA+ NIRTV + +ER+F E++ E +YG
Sbjct: 923 TGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYG 982
Query: 926 ----------------------------------PYRVFSAIVFGAVALGHASSFAPDYA 951
+RV SA+V A ALG A S+ P YA
Sbjct: 983 FCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYA 1042
Query: 952 KAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLE 1011
KAK+SAA F L +RQP I Y+ G K D F+G I F + F YP+R + VL GLS+
Sbjct: 1043 KAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVS 1102
Query: 1012 VKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQE 1071
+ GQTLA VGSSGCGKST +QLLERFYDP G V++DG ++KK+NVQ+LR+ +GIVSQE
Sbjct: 1103 ISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQE 1162
Query: 1072 PILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGG 1131
P+LF CSI +NI YGDN++ + + +++AAK A +H F+ +LP KYET VG +G+QLS G
Sbjct: 1163 PVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRG 1222
Query: 1132 QKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQN 1191
+KQRIAIARA++R P+ILLLDEATSALDTESEK VQ ALDKAREGRTCIVIAHRLSTIQN
Sbjct: 1223 EKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQN 1282
Query: 1192 ADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1224
AD+I V G V E GTH++L+AQKG Y+ +V+
Sbjct: 1283 ADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVT 1315
Score = 416 bits (1069), Expect = e-116
Identities = 227/586 (38%), Positives = 347/586 (59%), Gaps = 23/586 (3%)
Query: 56 FMSLGTIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTR 115
+M +G++ A +G+ PL +F ++ G FS P + ++
Sbjct: 754 YMLVGSVGAAVNGTVTPLYAFLFSQIL-------GTFSIPDK---------EEQRSQING 797
Query: 116 YAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDI--NDTTEL 173
+ +G L ++Q + + +++R+ F A+L Q+I WFD N L
Sbjct: 798 VCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGAL 857
Query: 174 NTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAV 233
TRL D S++ G ++GM + I+ F WKL+LVI+ P L LS A
Sbjct: 858 TTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGAT 917
Query: 234 WAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKK 293
++L+ F+ ++ A G + EAL IRTV G + + +E + LE + I+K
Sbjct: 918 QTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQK 977
Query: 294 AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPC 353
A A +++ + + ++ YG L+ ++ V ++++ A ++G+A
Sbjct: 978 ANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSY 1037
Query: 354 IDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILK 413
++A A+ +A F ++D P I ++ G K D+ +G ++F D F+YPSR + ++L
Sbjct: 1038 TPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLN 1097
Query: 414 GLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIG 473
GL++ + GQT+A VGSSGCGKST++QL++R YDPD+G + IDG D + NV +LR IG
Sbjct: 1098 GLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIG 1157
Query: 474 VVSQEPVLFSTTIAENICYGRG--NVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
+VSQEPVLF+ +I +NI YG + M+ + A K+A ++F+M LP+K++T VG +G+
Sbjct: 1158 IVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGS 1217
Query: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRL 591
QLS G+KQRIAIARA+VR+PKILLLDEATSALDTESE VQ ALDKAREGRT IVIAHRL
Sbjct: 1218 QLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRL 1277
Query: 592 STVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQI 637
ST++NAD+IA GV++E+G+H ELM ++G Y+KLV T+GS I
Sbjct: 1278 STIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV---TTGSPI 1320
Score = 363 bits (931), Expect = e-100
Identities = 222/653 (33%), Positives = 347/653 (53%), Gaps = 97/653 (14%)
Query: 667 TQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTE--WPYFVVGTVCAIANGGL 724
+ K+ N + + + + DG+ V F ++ + + + W FV G++CA +G
Sbjct: 22 SDKSYNNDKKSRLQDEKKGDGVR-----VGFFQLFRFSSSTDIWLMFV-GSLCAFLHGIA 75
Query: 725 QPAFSVIFSEIIAIFG-----------PGDDAVKQQ----------------KCNI---- 753
QP +IF + +F PG V +C +
Sbjct: 76 QPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLNQNMTNGTRCGLLNIE 135
Query: 754 -----FSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKN 808
F+ + + + T ++Q + A +++R F+ ++R ++ WFD N
Sbjct: 136 SEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDC--N 193
Query: 809 STGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIA 868
S G L+TR + D ++ A ++AL Q + + G ++ F GW+LTL++++V P+I
Sbjct: 194 SVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIG 253
Query: 869 VSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLY---- 924
+ ++ + K AG +A E I ++RTV + E++ Y + L
Sbjct: 254 IGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQR 313
Query: 925 --------------------------------------GPY------RVFSAIVFGAVAL 940
G Y ++F +++ GA+ L
Sbjct: 314 WGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNL 373
Query: 941 GHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRA 1000
G+AS +A + +A +F +R+P+ID SE+G K D+ +G I F+ V F+YP+R
Sbjct: 374 GNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRP 433
Query: 1001 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQW 1060
V +L L++ +K G+ ALVG SG GKST +QL++RFYDP G V +DG + + LN+QW
Sbjct: 434 EVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQW 493
Query: 1061 LRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETR 1120
LR Q+GIV QEP+LF +IAENI YG + ++IV AAK AN + FI LP +++T
Sbjct: 494 LRDQIGIVEQEPVLFSTTIAENIRYGRED--ATMEDIVQAAKEANAYNFIMDLPQQFDTL 551
Query: 1121 VGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCI 1180
VG+ G Q+SGGQKQR+AIARALIR P+ILLLD ATSALD ESE +VQE L K + G T I
Sbjct: 552 VGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTII 611
Query: 1181 VIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA-GTQNL 1232
+AHRLST++ AD I+ F++G E GTH++LL +KG+YF++V++Q+ G Q L
Sbjct: 612 SVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQAL 664
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 887 bits (2292), Expect = 0.0
Identities = 456/820 (55%), Positives = 597/820 (72%), Gaps = 58/820 (7%)
Query: 455 IDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEF 514
+D DIR NV + R+ IGVVSQEPVLF TTI+ NI YGR +VT +E+++A +EANAY+F
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAA 574
IM+ P KF+TLVGE+GAQ+SGGQKQRIAIARALVRNPKIL+LDEATSALD+ES++ VQAA
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 575 LDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSG 634
L+KA +GRTTIV+AHRLST+R+AD+I +DG++ E+G+H+ELM K G+Y+ LV
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLV------ 175
Query: 635 SQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
S++ + DE+ + K+ + K++K S K+ + T E ++P
Sbjct: 176 ---MSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIK-SDFIDKA-EESTQSKEISLPE 230
Query: 695 VSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIF 754
VS LK+LKLNK EWP+ V+GT+ ++ NG + P FS+IF++II +FG D + I+
Sbjct: 231 VSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIY 290
Query: 755 SLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALS 814
S+IF+ LG+I F ++F+QG +G+AGEILT RLR +AFKAML QD++WFD+ +NSTG L+
Sbjct: 291 SMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLT 350
Query: 815 TRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVE 874
T LA D AQ+QGATG+R+ ++ QN N+G +IISFIYGW++T L+L++ P++AV+G++E
Sbjct: 351 TILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIE 410
Query: 875 MKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLY---------- 924
+ G A +DK+EL+ AGKIATEA+ENIRT+VSLT+E+ FE MY E L
Sbjct: 411 TAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKA 470
Query: 925 -------------------------------------GPYRVFSAIVFGAVALGHASSFA 947
G + VF+AI +GA+A+G A
Sbjct: 471 QIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLA 530
Query: 948 PDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQG 1007
P+Y+KAK AAHLF L E++P IDS S+EG KPD EGN+ F EV F YP R +V +L+G
Sbjct: 531 PEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRG 590
Query: 1008 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGI 1067
LSL +++G+T+A VGSSGCGKST VQLL+R YDP+ G VL DG +AK+LNVQWLR+Q+ I
Sbjct: 591 LSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAI 650
Query: 1068 VSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQ 1127
V QEP+LF+CSIAENIAYGDNSRVV DEI AA AANIH FIE LP KY T+VG KG Q
Sbjct: 651 VPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQ 710
Query: 1128 LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1187
LSGGQKQR+AIARAL+++P+ILLLDEATSALD +SEKVVQ ALDKAR GRTC+V+ HRLS
Sbjct: 711 LSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLS 770
Query: 1188 TIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1227
IQNADLIVV NG++KE GTHQ+LL + IYF +V+ Q+
Sbjct: 771 AIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
Score = 429 bits (1104), Expect = e-120
Identities = 244/611 (39%), Positives = 362/611 (59%), Gaps = 24/611 (3%)
Query: 26 SSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTDKF 85
S++ K V ++ +L L + +W F+ LGT+ ++ +G+ P+ I+F ++ F
Sbjct: 220 STQSKEISLPEVSLLKILKLNK-PEWP---FVVLGTLASVLNGTVHPVFSIIFAKIITMF 275
Query: 86 VDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQ 145
GN N L+ + Y+ + LG V+ ++Q F+ A
Sbjct: 276 ----GN------------NDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEIL 319
Query: 146 IRKIRQKFFHAILRQEIGWFDI--NDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFF 203
++R F A+L Q+I WFD N T L T L DI++I G ++G+ Q
Sbjct: 320 TMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMG 379
Query: 204 AGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAI 263
I+ FI GW++T +I++I+P+L ++ + ++ F++K+ AG +A EAL I
Sbjct: 380 LSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENI 439
Query: 264 RTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
RT+++ + + Y++ L+ KKA + IY +YA F +G+ L+
Sbjct: 440 RTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLI 499
Query: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
+ T VF +I GA ++G+ ++ A+ A +F +++ P IDS S+
Sbjct: 500 QAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQE 559
Query: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
G KPD+ +GNLEF +V F YP R +V IL+GL+L ++ G+TVA VGSSGCGKST+VQL+Q
Sbjct: 560 GKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQ 619
Query: 444 RLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGN--VTMDE 501
RLYDP +G + DG D + NV +LR I +V QEPVLF+ +IAENI YG + V +DE
Sbjct: 620 RLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDE 679
Query: 502 IKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATS 561
IK+A AN + FI LP+K++T VG +GAQLSGGQKQR+AIARAL++ PKILLLDEATS
Sbjct: 680 IKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATS 739
Query: 562 ALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE 621
ALD +SE VQ ALDKAR GRT +V+ HRLS ++NAD+I +G I EQG+H EL++
Sbjct: 740 ALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNR 799
Query: 622 GVYFKLVNMQT 632
+YFKLVN Q+
Sbjct: 800 DIYFKLVNAQS 810
Score = 194 bits (494), Expect = 3e-49
Identities = 97/180 (53%), Positives = 137/180 (76%), Gaps = 2/180 (1%)
Query: 1047 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1106
++D + + LNV+ R +G+VSQEP+LF +I+ NI YG + V+ +E+ AA+ AN
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1107 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV 1166
+ FI P+K+ T VG+KG Q+SGGQKQRIAIARAL+R P+IL+LDEATSALD+ES+ V
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
Query: 1167 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
Q AL+KA +GRT IV+AHRLSTI++ADLIV ++G + E G H +L+A++G+Y+S+V Q
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 349 bits (895), Expect = 1e-95
Identities = 204/533 (38%), Positives = 299/533 (56%), Gaps = 4/533 (0%)
Query: 104 NPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIG 163
NP + +TR S + A I+V + R + ++R F +ILRQE+
Sbjct: 202 NPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVA 261
Query: 164 WFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAI 223
+FD T EL RL+ D + + + + + +A A G + F L ++++
Sbjct: 262 FFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSV 321
Query: 224 SPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
P + + A ++ + L + + A+A +AEE +G +RTV AFG + E+E+Y +
Sbjct: 322 VPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKV 381
Query: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
++ ++ K+A + G L + G L+ S T+G +
Sbjct: 382 DHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWV 441
Query: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSY 403
S+G + GA ++++++ PK+ S +G LEF +VHF+Y
Sbjct: 442 GISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAY 501
Query: 404 PSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNF 463
P+R V I + +L + SG ALVG SG GKST + L+ RLYDP GTI++DG DIR
Sbjct: 502 PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQL 561
Query: 464 NVNYLREIIGVVSQEPVLFSTTIAENICYGR---GNVTMDEIKKAVKEANAYEFIMKLPQ 520
N +LR IG VSQEP+LFS +IAENI YG +VT +EI++ + ANA FI PQ
Sbjct: 562 NPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQ 621
Query: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKARE 580
F+T+VGE+G LSGGQKQRIAIARAL++NPKILLLDEATSALD E+E VQ ALD+ +
Sbjct: 622 GFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD 681
Query: 581 GRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK-EGVYFKLVNMQT 632
GRT +VIAHRLST++NA+++A + G I E G H EL+ K G+Y KL+N Q+
Sbjct: 682 GRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
Score = 317 bits (811), Expect = 6e-86
Identities = 195/498 (39%), Positives = 276/498 (55%), Gaps = 51/498 (10%)
Query: 779 AGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQN 838
+G+ + RLR+ F ++LRQ++++FD K TG L RL++D A + + L+ +
Sbjct: 239 SGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRA 296
Query: 839 IANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATE 898
A GI + F L +L+VVP +++ ++ + L K + L A ++A E
Sbjct: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
Query: 899 AIENIRTVVSLTQERKFESMYVEK-----------------------LYGPYRVFSAIVF 935
I N+RTV + +E Y K L G V S +
Sbjct: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYK 416
Query: 936 GAVALGHA------------------------SSFAPDYAKAKLSAAHLFMLFERQPLID 971
G + +G A SSF + K + L+ L ER+P +
Sbjct: 417 GGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLP 476
Query: 972 SYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1031
L F+G + F V F YP R VP+ Q SL + G ALVG SG GKSTV
Sbjct: 477 FNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTV 536
Query: 1032 VQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG-DNSR 1090
+ LL R YDP +GT+ LDG + ++LN WLR+++G VSQEPILF CSIAENIAYG D+
Sbjct: 537 LSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPS 596
Query: 1091 VVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILL 1150
V+ +EI A+ AN FI P + T VG+KG LSGGQKQRIAIARAL++ P+ILL
Sbjct: 597 SVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILL 656
Query: 1151 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQ 1210
LDEATSALD E+E +VQEALD+ +GRT +VIAHRLSTI+NA+++ V G++ E+G H+
Sbjct: 657 LDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHE 716
Query: 1211 QLLAQ-KGIYFSMVSVQA 1227
+LL++ GIY +++ Q+
Sbjct: 717 ELLSKPNGIYRKLMNKQS 734
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 318 bits (815), Expect = 2e-86
Identities = 193/489 (39%), Positives = 284/489 (58%), Gaps = 11/489 (2%)
Query: 149 IRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIV 208
+R+ F ++LRQ+I +FD N T +L +RLT D+ + + ++ T AG +V
Sbjct: 210 MRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRS-CTQVAGCLV 268
Query: 209 GF-IRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVI 267
+ +LTL++M +P L + L S + A+A VA+EALG +RTV
Sbjct: 269 SLSMLSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVR 328
Query: 268 AFGGQNKELERYQKHLE----NAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 323
AF + +E ERY LE A+E+G A+ +S IAF + + G +LV
Sbjct: 329 AFAMEQREEERYGAELEACRCRAEELGRGIALFQGLS-NIAFNCMVLG---TLFIGGSLV 384
Query: 324 ISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSER 383
++ T G+ M+ + S+ + A +F+ + NP I
Sbjct: 385 AGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGC 444
Query: 384 GHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ 443
+ ++G++ F +V FSYP R ++LK L + G+ VALVG SG GK+T L++
Sbjct: 445 CVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLE 504
Query: 444 RLYDPDEGTINIDGQDIRNFNVNYLR-EIIGVVSQEPVLFSTTIAENICYGRGNVTMDEI 502
R YDP G + +DG+D+R + ++LR +++G +SQEPVLF TTI ENI +G+ + +E+
Sbjct: 505 RFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEV 564
Query: 503 KKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSA 562
A +EANA+EFI P+ ++T+VGERG LSGGQKQR+AIARAL++ P +L+LDEATSA
Sbjct: 565 YTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSA 624
Query: 563 LDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEG 622
LD ESE VQ ALD+A GRT +VIAHRLSTVR A I DG + E G+H EL+KK G
Sbjct: 625 LDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGG 684
Query: 623 VYFKLVNMQ 631
+Y +L+ Q
Sbjct: 685 LYAELIRRQ 693
Score = 300 bits (769), Expect = 4e-81
Identities = 192/526 (36%), Positives = 287/526 (54%), Gaps = 57/526 (10%)
Query: 752 NIFSLIFLFLGIISFFTFFLQGFT--FGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNS 809
N+ + + + G+ TF G+ GE + +R F ++LRQD+++FD N
Sbjct: 176 NLSTHLLILYGVQGLLTF---GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANK 230
Query: 810 TGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAV 869
TG L +RL TD + + + ++ ++ + ++ + +LTLLL+ P +
Sbjct: 231 TGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMG 290
Query: 870 SGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKL------ 923
G + L +++ ++++ A +A EA+ N+RTV + E++ E Y +L
Sbjct: 291 VGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCR 350
Query: 924 -------YGPYRVFSAIVFGAVALG-----------------HASSFAPDYAKAKLSAAH 959
++ S I F + LG SF + S A+
Sbjct: 351 AEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMAN 410
Query: 960 LFMLFER-----------------QPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANV 1002
L +LF + P I + ++ G++TF V F+YP R
Sbjct: 411 LSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGF 470
Query: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062
VL+ +L + G+ +ALVG SG GK+TV LLERFYDP AG V+LDG++ + L+ WLR
Sbjct: 471 EVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLR 530
Query: 1063 AQL-GIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRV 1121
Q+ G +SQEP+LF +I ENI +G S +E+ +AA+ AN H FI + P Y T V
Sbjct: 531 GQVVGFISQEPVLFGTTIMENIRFGKLE--ASDEEVYTAAREANAHEFITSFPEGYNTVV 588
Query: 1122 GDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIV 1181
G++GT LSGGQKQR+AIARALI+QP +L+LDEATSALD ESE+VVQEALD+A GRT +V
Sbjct: 589 GERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLV 648
Query: 1182 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1227
IAHRLST++ A IVV +GRV E GTH++LL + G+Y ++ QA
Sbjct: 649 IAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 314 bits (805), Expect = 3e-85
Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)
Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A + +
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
+ L + +YG LVIS + T GN + + + G
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
Score = 282 bits (721), Expect = 2e-75
Identities = 189/534 (35%), Positives = 267/534 (50%), Gaps = 56/534 (10%)
Query: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
Query: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
Query: 920 VEKL----------------------------------YGPYRVFS---------AIVFG 936
+ KL YG + V S A +
Sbjct: 392 LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIY 451
Query: 937 AVALGHASSFAPDYAKAKL----SAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEV 992
LG + +A +F +RQP + + L PD EG + F V
Sbjct: 452 EFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENV 509
Query: 993 VFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQE 1052
F Y TR + VLQ +S + G+ ALVG SG GKS+ V +LE FY G VLLDG+
Sbjct: 510 TFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKP 569
Query: 1053 AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET 1112
+ ++L + +VSQEP+LF SI +NI+YG V + +V AA+ AN H FI
Sbjct: 570 ISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
Query: 1113 LPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK 1172
L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE ++Q+A+
Sbjct: 628 LQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHG 687
Query: 1173 AREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
+ T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ G+Y +V Q
Sbjct: 688 NLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 314 bits (805), Expect = 3e-85
Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)
Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A + +
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
+ L + +YG LVIS + T GN + + + G
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
Score = 282 bits (721), Expect = 2e-75
Identities = 189/534 (35%), Positives = 267/534 (50%), Gaps = 56/534 (10%)
Query: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
Query: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
Query: 920 VEKL----------------------------------YGPYRVFS---------AIVFG 936
+ KL YG + V S A +
Sbjct: 392 LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIY 451
Query: 937 AVALGHASSFAPDYAKAKL----SAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEV 992
LG + +A +F +RQP + + L PD EG + F V
Sbjct: 452 EFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENV 509
Query: 993 VFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQE 1052
F Y TR + VLQ +S + G+ ALVG SG GKS+ V +LE FY G VLLDG+
Sbjct: 510 TFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKP 569
Query: 1053 AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET 1112
+ ++L + +VSQEP+LF SI +NI+YG V + +V AA+ AN H FI
Sbjct: 570 ISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
Query: 1113 LPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK 1172
L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE ++Q+A+
Sbjct: 628 LQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHG 687
Query: 1173 AREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
+ T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ G+Y +V Q
Sbjct: 688 NLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 298 bits (764), Expect = 2e-80
Identities = 186/491 (37%), Positives = 267/491 (54%), Gaps = 13/491 (2%)
Query: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
Query: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
Query: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
Query: 920 VEKLYGPYRV----FSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSE 975
+ KL Y++ +A ++ G S + +A +F +RQP + +
Sbjct: 392 LRKLQQVYKLNRKEAAAYMYYVWGSGSVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHD 449
Query: 976 EGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1035
L PD EG + F V F Y TR + VLQ +S + G+ ALVG SG GKS+ V +L
Sbjct: 450 GSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNIL 509
Query: 1036 ERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQD 1095
E FY G VLLDG+ + ++L + +VSQEP+LF SI +NI+YG V +
Sbjct: 510 ENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFE 567
Query: 1096 EIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEAT 1155
+V AA+ AN H FI L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEAT
Sbjct: 568 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 627
Query: 1156 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1215
SALD ESE ++Q+A+ + T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ
Sbjct: 628 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 687
Query: 1216 KGIYFSMVSVQ 1226
G+Y +V Q
Sbjct: 688 GGLYAKLVQRQ 698
Score = 295 bits (755), Expect = 2e-79
Identities = 176/514 (34%), Positives = 282/514 (54%), Gaps = 45/514 (8%)
Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA-------- 406
Query: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
A+Y W GS G+ +V+ ++ G G
Sbjct: 407 -------AAYMYYVW-GS----------GSVGSVYSGLMQGV-----------------G 431
Query: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 432 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 489
Query: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 490 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 549
Query: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 550 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 609
Query: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 610 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 669
Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 670 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 703
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 258 bits (658), Expect = 3e-68
Identities = 164/521 (31%), Positives = 267/521 (51%), Gaps = 5/521 (0%)
Query: 111 EEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDT 170
+ TR S L V ++ + G ++ + F A+LRQE +F N T
Sbjct: 282 DTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQT 341
Query: 171 TELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLS 230
+ +R+T+D S +S+ + + + +F + + LT+V + P+L L
Sbjct: 342 GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLL 401
Query: 231 AAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
K + + AK+ VA EAL A+ TV +F + E +++++ L+ K +
Sbjct: 402 PKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN 461
Query: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
K+A++ ++ + + G LV S + GN +T + +V
Sbjct: 462 QKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVL 521
Query: 351 APCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVK 410
A G++ IF+ +D P+ P ++G ++F DV F+YP+R +V
Sbjct: 522 LSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLL--TPLHLEGLVQFQDVSFAYPNRPDVL 579
Query: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
+L+GL ++ G+ ALVG +G GKST L+Q LY P G + +DG+ + + YL
Sbjct: 580 VLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHR 639
Query: 471 IIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
+ V QEP +F ++ ENI YG TM+EI A ++ A+ FI LPQ +DT V E
Sbjct: 640 QVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
Query: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA--REGRTTIVI 587
G+QLSGGQ+Q +A+ARAL+R P +L+LD+ATSALD S+ +V+ L ++ R R+ ++I
Sbjct: 700 GSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLI 759
Query: 588 AHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
LS V AD I E G I E G+H +LM+K+G Y+ +V
Sbjct: 760 TQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 800
Score = 224 bits (572), Expect = 3e-58
Identities = 160/493 (32%), Positives = 247/493 (50%), Gaps = 60/493 (12%)
Query: 787 LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
L+ F A+LRQ+ +F +N TG + +R+ D + + + L+L + G+
Sbjct: 320 LQGEVFGAVLRQETEFFQ--QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVR---GL 374
Query: 847 IISFIYGW---QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENI 903
+ I W LT++ L +P++ + K + ++ L + ++A EA+ +
Sbjct: 375 CLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAM 434
Query: 904 RTVVSLTQERKFESMYVEKLYG----------PYRVFS--------------------AI 933
TV S E + EKL Y V S +
Sbjct: 435 PTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLV 494
Query: 934 VFGAVALGHASSFA-----------------PDYAKAKLSAAHLFMLFERQPLIDSYSEE 976
GAV+ G+ +F P KA S+ +F +R P
Sbjct: 495 TSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL- 553
Query: 977 GLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE 1036
L P EG + F +V F YP R +V VLQGL+ ++ G+ ALVG +G GKSTV LL+
Sbjct: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
Query: 1037 RFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1096
Y P G +LLDG+ + ++L Q+ V QEP +F S+ ENIAYG + + +E
Sbjct: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQK-PTMEE 671
Query: 1097 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1156
I +AA + H FI LP Y+T V + G+QLSGGQ+Q +A+ARALIR+P +L+LD+ATS
Sbjct: 672 ITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATS 731
Query: 1157 ALDTESEKVVQEALDKA--REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1214
ALD S+ V++ L ++ R R+ ++I LS ++ AD I+ + G ++E GTHQQL+
Sbjct: 732 ALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLME 791
Query: 1215 QKGIYFSMVSVQA 1227
+KG Y++MV A
Sbjct: 792 KKGCYWAMVQAPA 804
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 243 bits (621), Expect = 6e-64
Identities = 165/505 (32%), Positives = 273/505 (54%), Gaps = 29/505 (5%)
Query: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
+T R +IR++ F ++LRQ++G+F T ELN+RL+ D + +S + + +
Sbjct: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273
Query: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
++ GF++ +LTL+ + P + V+ ++L D A A+
Sbjct: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327
Query: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
AG V EA+G ++TV +FG + E+ RY++ LE +++ ++ + + + + +L
Sbjct: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387
Query: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
L G + E T G+ + S +I SVG + D +N GAA
Sbjct: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442
Query: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
+F +D P + S P +++G ++F DV F+YP+R + +LKGL ++ G+ A
Sbjct: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
Query: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
LVG +G GKST L+Q LY P G + +D + I + YL + V QEPVLFS ++
Sbjct: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
Query: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
NI YG + D++ A + A+A +FI ++ T VGE+G+QL+ GQKQR+AIARA
Sbjct: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
Query: 547 LVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDG 606
LVR+P++L+LDEATSALD + E +Q +R RT +VIAHRL V+ A I ++G
Sbjct: 621 LVRDPRVLILDEATSALDVQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEG 678
Query: 607 VIVEQGSHSELMKKEGVYFKLVNMQ 631
+ + ++L + + +Y +LV +
Sbjct: 679 KLQKL---AQLQEGQDLYSRLVQQR 700
Score = 217 bits (553), Expect = 5e-56
Identities = 173/566 (30%), Positives = 274/566 (48%), Gaps = 82/566 (14%)
Query: 699 KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
++LKL++ + P V V A+ L P +S +I I G D + F+
Sbjct: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190
Query: 756 LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
F+ + SF + G G ++R R+R F ++LRQD+ +F + K TG
Sbjct: 191 SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248
Query: 813 LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
L++RL++D + ++ +++ + +YG+ +LTLL L +P
Sbjct: 249 LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302
Query: 867 IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
+ V + + + AG++ EA+ ++TV S E Y E
Sbjct: 303 TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362
Query: 922 -KLYGPYRVFSAIVF------------------------GAVALGHASSF------APDY 950
+LY + A+ G + G SF Y
Sbjct: 363 RQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSY 422
Query: 951 AKAKL-----------SAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR 999
+ + +A +F +RQP + S L P +G + F +V F YP R
Sbjct: 423 VQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQDVSFAYPNR 480
Query: 1000 ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQ 1059
+ PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G VLLD + +
Sbjct: 481 PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC 540
Query: 1060 WLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYET 1119
+L +Q+ V QEP+LF S+ NIAYG S D++++AA+AA+ FI+ + H T
Sbjct: 541 YLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHADDFIQEMEHGIYT 598
Query: 1120 RVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC 1179
VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E+ +Q+ +R RT
Sbjct: 599 DVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW--NSRGDRTV 656
Query: 1180 IVIAHRLSTIQNADLIVVFQNGRVKE 1205
+VIAHRL +Q A I+V Q G++++
Sbjct: 657 LVIAHRLQAVQRAHQILVLQEGKLQK 682
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 238 bits (608), Expect = 2e-62
Identities = 285/1171 (24%), Positives = 501/1171 (42%), Gaps = 188/1171 (16%)
Query: 198 AVATFFAGFIVGFIRGWKLTLVIMAISPILGLS-------AAVWAKILSA-FSDKELAAY 249
AV + AG V I G ++I+ + LG + A ++A L+A F K +AA
Sbjct: 292 AVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAAT 351
Query: 250 AKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIY 309
+ E L I+ + + + QK E + I K +I++G+A +++
Sbjct: 352 DERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVV 411
Query: 310 ASYALAF----WYGSTLVISKEYTIG---NAMTVFFSILIGAFSV---GQAAPCIDAFA- 358
+ + F G L ++ +T+ N+MT F++ + FSV +A+ +D F
Sbjct: 412 IASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMT--FALKVTPFSVKSLSEASVAVDRFKS 469
Query: 359 -----------NARGAAYVIFDI-------------IDNNPKI------DSFSERGHKPD 388
N + ++ ++ I N+PK+ D + RG K
Sbjct: 470 LFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEK 529
Query: 389 --------------SIKGNLEFNDVHFSYPSRANVK-----------ILKGLNLKVQSGQ 423
KG+L + P K L ++L++Q G+
Sbjct: 530 VRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGK 589
Query: 424 TVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFS 483
V + GS G GK++ + I EG+I I G V+Q+ + +
Sbjct: 590 LVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILN 636
Query: 484 TTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAI 543
T+ +NI +G+ + + + LP T +GERGA LSGGQ+QRI++
Sbjct: 637 ATLRDNILFGK-EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISL 695
Query: 544 ARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
ARAL + I +LD+ SALD + +A+ K + +T + + H+L + + D +
Sbjct: 696 ARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIF 755
Query: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNM----QTSGSQIQSEEFELNDEKAATRMAPNGW 658
++G I E+G+H ELM G Y + N +T +I S++ +K + P
Sbjct: 756 MKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTG 815
Query: 659 ---KSRLFRHSTQKNLKNSQMCQKSLDVETDG--LEANVPPVSFLKVLKLN--------- 704
K + + + ++ + Q S+ G ++A P++FL ++ L
Sbjct: 816 SVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF 875
Query: 705 KTEWPYFVV--GTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFSLIFLFLG 762
T W + + G+ G + + S D+ Q +I++L +
Sbjct: 876 STWWLSYWIKQGSGNTTVTRGNETSVSDSMK---------DNPHMQYYASIYALSMAVML 926
Query: 763 IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
I+ ++G F K + RL F+ +LR M +FD TG + R + D
Sbjct: 927 ILKA----IRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGRILNRFSKDMD 980
Query: 823 QVQGATGTRLALIAQNIANLGTGI-IISFIYGWQLTLLLLAVVPIIAVSGIVEM--KLLA 879
+V + + QN+ + + +I+ ++ W L+AV P++ + ++ + ++L
Sbjct: 981 EVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFSVLHIVSRVLI 1036
Query: 880 GNAKR-DKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKL---YGPYRVFS-AIV 934
KR D T +I+ + T+ + + ++F Y E L P+ +F+ A+
Sbjct: 1037 RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMR 1096
Query: 935 FGAVALGHAS----------------SFAPDYAKAKLS-AAHLFMLFERQPLIDSYSE-- 975
+ AV L S P YA +S A L LF+ + S +E
Sbjct: 1097 WLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEAR 1156
Query: 976 ------------------------EGLKPD-KFEGNITFNEVVFNYPTRANVP-VLQGLS 1009
+ PD EG +TF Y R N+P VL+ +S
Sbjct: 1157 FTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY--RENLPLVLKKVS 1214
Query: 1010 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVS 1069
+K + + +VG +G GKS++ L R + G + +DG + + LR++L I+
Sbjct: 1215 FTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIP 1274
Query: 1070 QEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLS 1129
QEP+LF ++ N+ D ++D+I A + ++ I LP K E+ V + G S
Sbjct: 1275 QEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFS 1331
Query: 1130 GGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTI 1189
G++Q + IARAL+R +IL+LDEAT+A+DTE++ ++QE + +A T + IAHRL T+
Sbjct: 1332 VGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTV 1391
Query: 1190 QNADLIVVFQNGRVKEHGTHQQLLAQKGIYF 1220
+D I+V G+V E T LL+ F
Sbjct: 1392 LGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
Score = 147 bits (371), Expect = 6e-35
Identities = 141/534 (26%), Positives = 248/534 (46%), Gaps = 43/534 (8%)
Query: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
M YA Y+ A +L+ I+ + R ++ + F ILR + +FD T
Sbjct: 911 MQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
Query: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRG---WKLTLV--IMAISPIL 227
+ R + D+ ++ + + MF Q V F F VG I G W L V ++ + +L
Sbjct: 971 ILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMIAGVFPWFLVAVGPLVILFSVL 1028
Query: 228 GLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLEN-- 285
+ + V + L + + + + ++ + T+ A+ + L RYQ+ L++
Sbjct: 1029 HIVSRVLIRELKRLDNITQSPFL---SHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQ 1085
Query: 286 ---------AKEIGIKK---AISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNA 333
+ + ++ +I+ + G+ +L++ A+ + L IS Y +
Sbjct: 1086 APFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAY---AGLAIS--YAV--Q 1138
Query: 334 MTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-SIKG 392
+T F F+V A+ F + + I + P + PD +G
Sbjct: 1139 LTGLFQ-----FTVRLASETEARFTSVERINHYIKTLSLEAPA--RIKNKAPSPDWPQEG 1191
Query: 393 NLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
+ F + Y R N+ +LK ++ ++ + + +VG +G GKS+ + RL + G
Sbjct: 1192 EVTFENAEMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGG 1249
Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
I IDG I + + LR + ++ QEPVLFS T+ N+ T D+I A++ +
Sbjct: 1250 CIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNL-DPFNQYTEDQIWDALERTHM 1308
Query: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
E I +LP K ++ V E G S G++Q + IARAL+R+ KIL+LDEAT+A+DTE++ +
Sbjct: 1309 KECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
Query: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
Q + +A T + IAHRL TV +D I G +VE + S L+ + F
Sbjct: 1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRF 1422
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 236 bits (601), Expect = 1e-61
Identities = 175/490 (35%), Positives = 252/490 (51%), Gaps = 43/490 (8%)
Query: 176 RLTDDISKISE-GIGDKVGMF----FQAVATFFAGFIVG------FIRGWKLTLVIMAIS 224
R T ++ +I++ G G+ F + T A I+G F W +V + +S
Sbjct: 364 RRTGEVLRIADRGTSSVTGLLSYLVFNVIPTL-ADIIIGIIYFSMFFNAWFGLIVFLCMS 422
Query: 225 PILGLSAAV--W-AKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQK 281
L L+ V W K A + +E A A+A ++L TV + ++ E+ERY++
Sbjct: 423 LYLTLTIVVTEWRTKFRRAMNTQENATRARA----VDSLLNFETVKYYNAESYEVERYRE 478
Query: 282 HLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSIL 341
+ + + K + S + L+I + V ++ +G+ +L
Sbjct: 479 AIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDY------VL 532
Query: 342 IGAFSVGQAAPCIDAFANARGAAYVIF--DIIDNNPKIDSFSERGHKPDSI--------K 391
G + + P N G Y + + ID D E D K
Sbjct: 533 FGTYIIQLYMPL-----NWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQK 587
Query: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
G +EF +VHFSY L+ ++ V GQT+ALVG SG GKST ++L+ R YD G
Sbjct: 588 GRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSG 645
Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
I IDGQDI LR IGVV Q+ VLF+ TIA+NI YGR DE++ A + A
Sbjct: 646 CIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGI 705
Query: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
++ IM P+ + T VGERG +LSGG+KQR+AIAR +++ P I+LLDEATSALDT +E +
Sbjct: 706 HDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765
Query: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
QA+L K RTTIV+AHRLSTV NAD I +DG IVE+G H L+ + GVY + +Q
Sbjct: 766 QASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
Query: 632 TSGSQIQSEE 641
G + SE+
Sbjct: 826 -QGQEETSED 834
Score = 221 bits (564), Expect = 3e-57
Identities = 121/256 (47%), Positives = 172/256 (67%), Gaps = 7/256 (2%)
Query: 977 GLKPDKFE-GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1035
G P +F+ G I F V F+Y LQ +S V GQTLALVG SG GKST+++LL
Sbjct: 579 GAGPLRFQKGRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLL 636
Query: 1036 ERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVS-Q 1094
RFYD +G + +DGQ+ ++ LR+ +G+V Q+ +LF+ +IA+NI YG RV +
Sbjct: 637 FRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYG---RVTAGN 693
Query: 1095 DEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEA 1154
DE+ +AA+AA IH I P Y T+VG++G +LSGG+KQR+AIAR +++ P I+LLDEA
Sbjct: 694 DEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEA 753
Query: 1155 TSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1214
TSALDT +E+ +Q +L K RT IV+AHRLST+ NAD I+V ++G + E G H+ LL+
Sbjct: 754 TSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLS 813
Query: 1215 QKGIYFSMVSVQAGTQ 1230
+ G+Y M +Q G +
Sbjct: 814 RGGVYADMWQLQQGQE 829
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 223 bits (569), Expect = 7e-58
Identities = 221/898 (24%), Positives = 393/898 (43%), Gaps = 125/898 (13%)
Query: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
+L ++ V+ G+ + + G+ G GKS+ + + +G + ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530
+ VSQ+ +F + ENI +G + V+ + + LP T +GERG
Sbjct: 543 -LAYVSQQAWIFHGNVRENILFGE-KYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 531 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAH 589
LSGGQ+QRI++ARA+ + ++ LLD+ SA+D V + + K G+T +++ H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 590 RLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELN---- 645
+L + + D + EDG I E+G+H ELM++ G Y KL++ G Q + E N
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIH-NLRGLQFKDPEHLYNAAMV 719
Query: 646 ---DEKAATR--------MAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEANVPP 694
E A R +AP K T ++++ + L E V
Sbjct: 720 EAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVTW 779
Query: 695 VSFLKVLKLNK-------TEWPYFVVGTVCAIANGGLQ------------PAFSVIFSEI 735
++ +K + T + + ++ A +N L P + E+
Sbjct: 780 KTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEV 839
Query: 736 IAIFGPGDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAM 795
A+ V Q + L G+ +GF F K + + L F +
Sbjct: 840 GAVLADIGQHVYQWVYTASMVFMLVFGVT-------KGFVFTKTTLMASSSLHDTVFDKI 892
Query: 796 LRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQ 855
L+ MS+FD TG L R + D ++ RL A+N L ++ FI
Sbjct: 893 LKSPMSFFDT--TPTGRLMNRFSKDMDELD----VRLPFHAENF--LQQFFMVVFIL--- 941
Query: 856 LTLLLLAVVP---IIAVSGIVEMKLLAGNAKRDKKELEAAGKIA--------TEAIENIR 904
++L AV P ++ S V +L R +EL+ ++ T +++ +
Sbjct: 942 --VILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLG 999
Query: 905 TVVSLTQERKFESMYVEKLYGPYRVFSA-------IVFGAVALGHASSFAPDYAKAK-LS 956
+ + ++ + ++ R F+ I+ VAL SF+ +K LS
Sbjct: 1000 IIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLS 1059
Query: 957 AAHLFML-----------------FERQPLIDSYSEE-----------GLKPDKF--EGN 986
+++ L F L+ Y G P + G
Sbjct: 1060 LSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTCPKDWPSRGE 1119
Query: 987 ITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGT 1045
ITF + Y R N P VL L+L ++ GQT+ +VG +G GKS++ L R +P +GT
Sbjct: 1120 ITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGT 1177
Query: 1046 VLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAAN 1105
+ +D + L+++ LR +L ++ Q+P+LF ++ N+ D + + + +
Sbjct: 1178 IFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHTDEMLWQVLERTF 1234
Query: 1106 IHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKV 1165
+ I LP K + V + G S G++Q + +ARAL+R +I+LLDEAT+++D++++ +
Sbjct: 1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTL 1294
Query: 1166 VQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
VQ + A +G T + IAHRL+T+ N D ++V +NG+V E + L + F+M+
Sbjct: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
Score = 149 bits (375), Expect = 2e-35
Identities = 88/238 (36%), Positives = 137/238 (57%), Gaps = 2/238 (0%)
Query: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
+G + F D Y + +L LNL +QSGQTV +VG +G GKS+ + RL +P
Sbjct: 1117 RGEITFRDYQMRYRDNTPL-VLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPAS 1175
Query: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
GTI ID DI ++ LR + V+ Q+PVLF T+ N+ + T + + + ++
Sbjct: 1176 GTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH-TDEMLWQVLERTF 1234
Query: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
+ IMKLP+K V E G S G++Q + +ARAL+RN KI+LLDEAT+++D++++
Sbjct: 1235 MRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSKTDTL 1294
Query: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
VQ + A +G T + IAHRL+TV N D + E+G ++E L +K F ++
Sbjct: 1295 VQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKPDSAFAML 1352
Score = 118 bits (295), Expect = 4e-26
Identities = 67/228 (29%), Positives = 120/228 (52%), Gaps = 17/228 (7%)
Query: 1004 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1063
VL +S V+KG+ L + G+ G GKS+++ L G V ++G
Sbjct: 495 VLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------------ 542
Query: 1064 QLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGD 1123
L VSQ+ +F ++ ENI +G+ + + + LP+ T +G+
Sbjct: 543 -LAYVSQQAWIFHGNVRENILFGEK---YDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
Query: 1124 KGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIVI 1182
+G LSGGQ+QRI++ARA+ Q+ LLD+ SA+D K V +E + K G+T +++
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 1183 AHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
H+L +++ D +++ ++G + E GTH++L+ ++G Y ++ G Q
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQ 706
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 223 bits (568), Expect = 9e-58
Identities = 147/442 (33%), Positives = 240/442 (54%), Gaps = 24/442 (5%)
Query: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
+T R +IR++ F ++LRQ++G+F T ELN+RL+ D + +S + + +
Sbjct: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273
Query: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
++ GF++ +LTL+ + P + V+ ++L D A A+
Sbjct: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327
Query: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
AG V EA+G ++TV +FG + E+ RY++ LE +++ ++ + + + + +L
Sbjct: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387
Query: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
L G + E T G+ + S +I SVG + D +N GAA
Sbjct: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442
Query: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
+F +D P + S P +++G ++F DV F+YP+R + +LKGL ++ G+ A
Sbjct: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
Query: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
LVG +G GKST L+Q LY P G + +D + I + YL + V QEPVLFS ++
Sbjct: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
Query: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
NI YG + D++ A + A+A +FI ++ T VGE+G+QL+ GQKQR+AIARA
Sbjct: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
Query: 547 LVRNPKILLLDEATSALDTESE 568
LVR+P++L+LDEATSALD + E
Sbjct: 621 LVRDPRVLILDEATSALDVQCE 642
Score = 191 bits (484), Expect = 5e-48
Identities = 157/525 (29%), Positives = 248/525 (47%), Gaps = 80/525 (15%)
Query: 699 KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
++LKL++ + P V V A+ L P +S +I I G D + F+
Sbjct: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190
Query: 756 LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
F+ + SF + G G ++R R+R F ++LRQD+ +F + K TG
Sbjct: 191 SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248
Query: 813 LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
L++RL++D + ++ +++ + +YG+ +LTLL L +P
Sbjct: 249 LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302
Query: 867 IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
+ V + + + AG++ EA+ ++TV S E Y E
Sbjct: 303 TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362
Query: 922 -KLYGPYRVFSAIVF------------------------GAVALGHASSF------APDY 950
+LY + A+ G + G SF Y
Sbjct: 363 RQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSY 422
Query: 951 AKAKL-----------SAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR 999
+ + +A +F +RQP + S L P +G + F +V F YP R
Sbjct: 423 VQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQDVSFAYPNR 480
Query: 1000 ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQ 1059
+ PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G VLLD + +
Sbjct: 481 PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC 540
Query: 1060 WLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYET 1119
+L +Q+ V QEP+LF S+ NIAYG S D++++AA+AA+ FI+ + H T
Sbjct: 541 YLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHADDFIQEMEHGIYT 598
Query: 1120 RVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1164
VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E+
Sbjct: 599 DVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 202 bits (515), Expect = 1e-51
Identities = 205/920 (22%), Positives = 387/920 (42%), Gaps = 145/920 (15%)
Query: 409 VKILKGLNLKVQSGQTVALVGSSGCGKSTTVQL----IQRLY---------------DPD 449
+ L + +++ GQ +VG GCGKS+ + +Q++ DP
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
DIR R + SQ+P L + T+ ENI + K ++
Sbjct: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEAC 805
Query: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
+ I LP T +GERG LSGGQ+QRI++ARAL ++ ++ LD+ SALD
Sbjct: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
Query: 570 EVQAA--LDKAREG-RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFK 626
+ A L+ R+ RT +++ H+L + +AD I +DG I +G+ + + E F+
Sbjct: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFE 925
Query: 627 ----LVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLD 682
L+N Q Q E E E+ AT P G + + + + +
Sbjct: 926 HWKTLMNRQD-----QELEKETVTERKATE-PPQGLSRAMSSRDGLLQDEEEEEEEAAES 979
Query: 683 VETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCA--IANGGLQPAFSVIFSEII---- 736
E D L + + + E P+ CA +++ G+ ++FS+++
Sbjct: 980 EEDDNLSSMLH----------QRAEIPW----RACAKYLSSAGILLLSLLVFSQLLKHMV 1025
Query: 737 ----------------AIFGPGDDAVKQQKCN----IFSLIFLFLGIISFFTFFLQGFTF 776
+ + Q+C +++++F L + + T
Sbjct: 1026 LVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTV 1085
Query: 777 GKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQV-QGATGTRLALI 835
G + +RL ++ M +F+ G++ R ++D + Q T L
Sbjct: 1086 EWTGLKVAKRLHRSLLNRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLS 1143
Query: 836 AQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKI 895
+ + +IS++ + L+A++P+ V ++ A RD ++L+ ++
Sbjct: 1144 RSTLLCVSALAVISYV----TPVFLVALLPLAIVCYFIQKYFRV--ASRDLQQLDDTTQL 1197
Query: 896 A-----TEAIENIRTVVSLTQERKFE-------------SMYVEKLYGPYRVFSAIVFGA 937
E +E + T+ + E +F+ S+++ V +
Sbjct: 1198 PLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC 1257
Query: 938 VALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSE-------------------EGL 978
V L A + + +LSA + + ++ +Y GL
Sbjct: 1258 VVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGL 1317
Query: 979 ---KPDKFEGNITFNEVVFNYPTRANV--------------PVLQGLSLEVKKGQTLALV 1021
+ + +EG + + + N+P + + PVL+ ++ + GQ + +
Sbjct: 1318 LKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGIC 1377
Query: 1022 GSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1081
G +G GKS+ R D G +++DG + KL + LR++L I+ Q+P+LF +I
Sbjct: 1378 GRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRF 1437
Query: 1082 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1141
N+ D R S + A + A + ++ LP + + + G S GQ+Q +ARA
Sbjct: 1438 NL---DPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARA 1494
Query: 1142 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1201
+R+ I ++DEAT+++D +E ++Q+ + A RT + IAHR+ TI +ADL++V + G
Sbjct: 1495 FVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRG 1554
Query: 1202 RVKEHGTHQQLLAQKGIYFS 1221
+ E ++LL++K F+
Sbjct: 1555 AILEFDKPEKLLSRKDSVFA 1574
Score = 120 bits (302), Expect = 6e-27
Identities = 76/239 (31%), Positives = 127/239 (53%), Gaps = 3/239 (1%)
Query: 391 KGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE 450
+G ++ ++ Y S +LK +N + GQ + + G +G GKS+ R+ D E
Sbjct: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
Query: 451 GTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEAN 510
G I IDG DI ++ LR + ++ Q+PVLFS TI N+ R + + +A++ A
Sbjct: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPER-KCSDSTLWEALEIAQ 1458
Query: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
+ LP D ++ E G S GQ+Q +ARA VR I ++DEAT+++D +E
Sbjct: 1459 LKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENI 1518
Query: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLV 628
+Q + A RT + IAHR+ T+ +AD++ + G I+E +L+ +K+ V+ V
Sbjct: 1519 LQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFV 1577
Score = 107 bits (266), Expect = 9e-23
Identities = 64/228 (28%), Positives = 119/228 (52%), Gaps = 21/228 (9%)
Query: 998 TRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG------- 1050
T +P L +++ + +GQ +VG GCGKS+++ ++G V
Sbjct: 689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748
Query: 1051 -------QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
+ A L+++ R + SQ+P L + ++ ENI + ++ +A
Sbjct: 749 EDPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIF---ESPFNKQRYKMVIEA 804
Query: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
++ P I+ LPH +T++G++G LSGGQ+QRI++ARAL + ++ LD+ SALD
Sbjct: 805 CSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLS 864
Query: 1164 KVVQEA--LDKAREG-RTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1208
+ +A L+ R+ RT +++ H+L + +AD I+ ++G ++ GT
Sbjct: 865 DHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGT 912
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 200 bits (509), Expect = 6e-51
Identities = 173/651 (26%), Positives = 301/651 (46%), Gaps = 55/651 (8%)
Query: 10 TAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYS----DWQDKLFMSLGTIMAI 65
T W + G L K+ K T K+I + + + D + ++ +SLG +
Sbjct: 95 TCWHGHAGGG---LHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFL--- 148
Query: 66 AHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKILEEEMTRYAYYYSGLGA 125
G M IV M VD+ S + L+L + + T Y A
Sbjct: 149 ---GGAKAMNIVVPFMFKYAVDSLNQMSGNM---LNLSDAPNTVATMATAVLIGYGVSRA 202
Query: 126 GVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKIS 185
G ++ + + A IR+I + F + ++G+ T L+ + IS
Sbjct: 203 GAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGIS 262
Query: 186 EGIGDKVGMFFQAVATFFAGFIVGFIRGWK-------LTLVIMAISPILGLSAAVWAKIL 238
+ + F + F +V + +K +TL + ++ W
Sbjct: 263 FVLS---ALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWR--- 316
Query: 239 SAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISAN 298
+ F + A AG A ++L TV F + E +RY L+ + +K +
Sbjct: 317 TRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTST-- 374
Query: 299 ISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFA 358
+A L S + + +V++ + + +TV +++ + P
Sbjct: 375 ----LAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPL----- 425
Query: 359 NARGAAY-----------VIFDIIDNNPKI-DSFSERGHKPDSIKGNLEFNDVHFSYPSR 406
N G Y +F ++ + +I D + + F++VHF Y
Sbjct: 426 NFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE- 484
Query: 407 ANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVN 466
K+L G++ +V +G+ VA+VG SG GKST V+L+ R Y+P +G+I + GQ+I++ ++
Sbjct: 485 -GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLE 543
Query: 467 YLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLV 526
LR +GVV Q+ VLF TI N+ YG + + +E+ K A ++ I+++P +DT V
Sbjct: 544 SLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQV 603
Query: 527 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIV 586
GERG +LSGG+KQR+AIARA++++P ++L DEATS+LD+ +E + A+ + RT+I
Sbjct: 604 GERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIF 663
Query: 587 IAHRLSTVRNADVIAGFEDGVIVEQGSHSELM-KKEGVYFKLVNMQTSGSQ 636
IAHRLSTV +AD I + G + E+G+H L+ +Y ++ + Q+S Q
Sbjct: 664 IAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQ 714
Score = 198 bits (504), Expect = 2e-50
Identities = 107/242 (44%), Positives = 159/242 (65%), Gaps = 5/242 (2%)
Query: 987 ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV 1046
+ F+ V F Y V L G+S EV G+ +A+VG SG GKST+V+LL RFY+P G++
Sbjct: 473 VAFDNVHFEYIEGQKV--LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSI 530
Query: 1047 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1106
L GQ + ++++ LR +G+V Q+ +LF +I N+ YG+ S S +E+ + AK A +
Sbjct: 531 YLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNIS--ASPEEVYAVAKLAGL 588
Query: 1107 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVV 1166
H I +PH Y+T+VG++G +LSGG+KQR+AIARA+++ P ++L DEATS+LD+ +E+ +
Sbjct: 589 HDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI 648
Query: 1167 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSV 1225
A+ + RT I IAHRLST+ +AD I+V G+V E GTH LLA IY M
Sbjct: 649 LGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHT 708
Query: 1226 QA 1227
Q+
Sbjct: 709 QS 710
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 149 bits (377), Expect = 1e-35
Identities = 136/527 (25%), Positives = 249/527 (47%), Gaps = 27/527 (5%)
Query: 110 EEEMTRYAYYYSGLGAGVLV-AAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDIN 168
+ +M Y GL G+ V A+ +F + A + K + + ILR + +FD
Sbjct: 1019 QRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHK---QLLNNILRAPMRFFDTT 1075
Query: 169 DTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILG 228
T + R DIS + D + ++ T F G I + T V I LG
Sbjct: 1076 PTGRIVNRFAGDISTVD----DTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLG 1131
Query: 229 LSAAVWAKILSAFSDKEL-----AAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHL 283
+ V ++ + ++L + + E + + + AF Q + L+ + +
Sbjct: 1132 I-IYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRI 1190
Query: 284 ENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIG 343
+ ++ + I++N + I L+ F+ +VI ++ G+ TV F +L
Sbjct: 1191 DTNQKC-VFSWITSNRWLAIRLELV--GNLTVFFSALMMVIYRDTLSGD--TVGF-VLSN 1244
Query: 344 AFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDS----FSERGHKPD-SIKGNLEFND 398
A ++ Q + + V + I K+++ +++ PD KG ++FN+
Sbjct: 1245 ALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNN 1304
Query: 399 VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
Y ++ +L+G+ + S + + +VG +G GKS+ + R+ + G I IDG
Sbjct: 1305 YQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGV 1363
Query: 459 DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKL 518
DI + ++ LRE + ++ Q+P+LFS ++ N+ N + +EI KA++ A+ F+ L
Sbjct: 1364 DIASIGLHDLREKLTIIPQDPILFSGSLRMNLD-PFNNYSDEEIWKALELAHLKSFVASL 1422
Query: 519 PQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA 578
V E G LS GQ+Q + + RAL+R KIL+LDEAT+A+D E++ +Q +
Sbjct: 1423 QLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNE 1482
Query: 579 REGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYF 625
T I IAHRL T+ ++D + ++G I+E GS EL++ G ++
Sbjct: 1483 FAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
Score = 142 bits (358), Expect = 2e-33
Identities = 82/249 (32%), Positives = 144/249 (57%), Gaps = 5/249 (2%)
Query: 984 EGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043
+G I FN Y ++ VL+G++ ++ + + +VG +G GKS++ L R +
Sbjct: 1297 KGKIQFNNYQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAG 1355
Query: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
G +++DG + + + LR +L I+ Q+PILF S+ N+ +N S +EI A +
Sbjct: 1356 GQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNN---YSDEEIWKALEL 1412
Query: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
A++ F+ +L V + G LS GQ+Q + + RAL+R+ +IL+LDEAT+A+D E++
Sbjct: 1413 AHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETD 1472
Query: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
++Q + T I IAHRL TI ++D ++V NG++ E G+ ++LL G ++ M
Sbjct: 1473 NLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMA 1532
Query: 1224 SVQAGTQNL 1232
+AG +N+
Sbjct: 1533 K-EAGIENV 1540
Score = 102 bits (253), Expect = 3e-21
Identities = 115/482 (23%), Positives = 204/482 (42%), Gaps = 78/482 (16%)
Query: 394 LEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTI 453
++F++ F++ + + + +NL + +GQ VA++G G GKS+ + + + G I
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHI 695
Query: 454 NIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE 513
I G V Q+ + + TI +NI +G ++ ++
Sbjct: 696 TIKGTT-------------AYVPQQSWIQNGTIKDNILFGT-EFNEKRYQQVLEACALLP 741
Query: 514 FIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQA 573
+ LP +GE+G LSGGQKQRI++ARA +N I LLD+ SA+D +
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 574 AL---DKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
+ + +G+T +++ H + + D I +G IVE+GS+S L+ K+G + K N+
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAK--NL 859
Query: 631 QT--------------SGSQIQSEEF-------ELNDEKAATRMAPNGWKSRLFRHSTQK 669
+T GS+ + +++ E+ ++ A+ M R S++
Sbjct: 860 KTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRS 919
Query: 670 NLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVC------AIANGG 723
N ++ + + SL +T + + +K KL K E + G V + G
Sbjct: 920 NGRHLKSLRNSL--KTRNVNSLKEDEELVKGQKLIKKE--FIETGKVKFSIYLEYLQAIG 975
Query: 724 LQPAFSVIFSEII-------------------AIFGPGDDAVKQQ--KCNIFSLIFLFLG 762
L F +I + ++ IF D Q+ + ++ + L G
Sbjct: 976 LFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQG 1035
Query: 763 IISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAA 822
I F F F F A IL ++L +LR M +FD TG + R A D +
Sbjct: 1036 IFVFIAHFWSAFGFVHASNILHKQL----LNNILRAPMRFFD--TTPTGRIVNRFAGDIS 1089
Query: 823 QV 824
V
Sbjct: 1090 TV 1091
Score = 98.6 bits (244), Expect = 3e-20
Identities = 66/238 (27%), Positives = 119/238 (50%), Gaps = 20/238 (8%)
Query: 983 FEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPL 1042
F+ + F+E F + + V + ++L++ GQ +A++G G GKS+++ + + +
Sbjct: 633 FDKAMQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENV 691
Query: 1043 AGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAK 1102
G + + G A W++ + +I +NI +G +++ A
Sbjct: 692 HGHITIKGTTAYVPQQSWIQ-------------NGTIKDNILFGTEFNEKRYQQVLEACA 738
Query: 1103 AANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1162
+ P +E LP +G+KG LSGGQKQRI++ARA + I LLD+ SA+D
Sbjct: 739 ---LLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHV 795
Query: 1163 EKVVQEAL---DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1217
K + + + +G+T +++ H + + D IVV NG + E G++ LLA+KG
Sbjct: 796 GKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKG 853
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 145 bits (365), Expect = 3e-34
Identities = 92/248 (37%), Positives = 140/248 (56%), Gaps = 5/248 (2%)
Query: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENIC-YGRGNVTMDEIKKAVKEAN 510
I IDG DI + + LR + V+ Q+PVL S TI N+ + R T +I A++
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH--TDQQIWDALERTF 1255
Query: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
+ I K P+K T V E G S G++Q + IARA++RN KI+L+DEAT+++D E++
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1315
Query: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
+Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-M 1374
Query: 631 QTSGSQIQ 638
T+ S ++
Sbjct: 1375 ATATSSLR 1382
Score = 139 bits (351), Expect = 1e-32
Identities = 80/244 (32%), Positives = 140/244 (57%), Gaps = 6/244 (2%)
Query: 985 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043
G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A
Sbjct: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
Query: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
G +L+DG + + ++ LR++L ++ Q+P+L +I N+ D + +I A +
Sbjct: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH---TDQQIWDALER 1253
Query: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
+ I P K T V + G S G++Q + IARA++R +I+L+DEAT+++D E++
Sbjct: 1254 TFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETD 1313
Query: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + G F+ +
Sbjct: 1314 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1373
Query: 1224 SVQA 1227
A
Sbjct: 1374 MATA 1377
Score = 114 bits (285), Expect = 6e-25
Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%)
Query: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062
P L ++L V KG L + G++G GKS+++ + L G+V + G
Sbjct: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573
Query: 1063 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1122
L V Q+ + +I ENI G + + +++ +E LP T +G
Sbjct: 574 --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628
Query: 1123 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1181
++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K G+T ++
Sbjct: 629 ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688
Query: 1182 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
+ H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++
Sbjct: 689 VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 102 bits (253), Expect = 3e-21
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)
Query: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
L +NL V G + + G++G GKS+ + I EG++ + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
Query: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
+ V Q+ + S I ENI G G + + + + LP T +GERG
Sbjct: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
Query: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
L + I E+G I E G+HSELM+K+G Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 145 bits (365), Expect = 3e-34
Identities = 92/248 (37%), Positives = 140/248 (56%), Gaps = 5/248 (2%)
Query: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
G + F D H Y +L G+NL ++ + V +VG +G GKS+ + RL +P G
Sbjct: 1139 GEIIFQDYHMKYRDNTPT-VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAG 1197
Query: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENIC-YGRGNVTMDEIKKAVKEAN 510
I IDG DI + + LR + V+ Q+PVL S TI N+ + R T +I A++
Sbjct: 1198 RILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH--TDQQIWDALERTF 1255
Query: 511 AYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAE 570
+ I K P+K T V E G S G++Q + IARA++RN KI+L+DEAT+++D E++
Sbjct: 1256 LTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTL 1315
Query: 571 VQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM 630
+Q + +A +G T +VIAHR++TV N D I +G +VE L KK G F + M
Sbjct: 1316 IQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL-M 1374
Query: 631 QTSGSQIQ 638
T+ S ++
Sbjct: 1375 ATATSSLR 1382
Score = 139 bits (351), Expect = 1e-32
Identities = 80/244 (32%), Positives = 140/244 (57%), Gaps = 6/244 (2%)
Query: 985 GNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043
G I F + Y R N P VL G++L ++ + + +VG +G GKS++ L R +P+A
Sbjct: 1139 GEIIFQDYHMKY--RDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMA 1196
Query: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
G +L+DG + + ++ LR++L ++ Q+P+L +I N+ D + +I A +
Sbjct: 1197 GRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH---TDQQIWDALER 1253
Query: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
+ I P K T V + G S G++Q + IARA++R +I+L+DEAT+++D E++
Sbjct: 1254 TFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATASIDMETD 1313
Query: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L + G F+ +
Sbjct: 1314 TLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKPGSLFAAL 1373
Query: 1224 SVQA 1227
A
Sbjct: 1374 MATA 1377
Score = 114 bits (285), Expect = 6e-25
Identities = 68/222 (30%), Positives = 117/222 (52%), Gaps = 17/222 (7%)
Query: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062
P L ++L V KG L + G++G GKS+++ + L G+V + G
Sbjct: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS----------- 573
Query: 1063 AQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVG 1122
L V Q+ + +I ENI G + + +++ +E LP T +G
Sbjct: 574 --LAYVPQQAWIVSGNIRENILMGG---AYDKARYLQVLHCCSLNRDLELLPFGDMTEIG 628
Query: 1123 DKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDKAREGRTCIV 1181
++G LSGGQKQRI++ARA+ QI LLD+ SA+D K + +E + K G+T ++
Sbjct: 629 ERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVL 688
Query: 1182 IAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMV 1223
+ H+L ++ I++ +NG++ E+GTH +L+ +KG Y ++
Sbjct: 689 VTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
Score = 102 bits (253), Expect = 3e-21
Identities = 69/218 (31%), Positives = 109/218 (50%), Gaps = 15/218 (6%)
Query: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
L +NL V G + + G++G GKS+ + I EG++ + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS------------- 573
Query: 472 IGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGA 531
+ V Q+ + S I ENI G G + + + + LP T +GERG
Sbjct: 574 LAYVPQQAWIVSGNIRENILMG-GAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGL 632
Query: 532 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHR 590
LSGGQKQRI++ARA+ + +I LLD+ SA+D + + + K G+T +++ H+
Sbjct: 633 NLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQ 692
Query: 591 LSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
L + I E+G I E G+HSELM+K+G Y +L+
Sbjct: 693 LQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLI 730
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 144 bits (364), Expect = 4e-34
Identities = 76/238 (31%), Positives = 138/238 (57%), Gaps = 4/238 (1%)
Query: 985 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1044
G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R + G
Sbjct: 1235 GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1293
Query: 1045 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1104
+++DG K+ + LR ++ I+ Q+P+LF S+ N+ D S +E+ ++ + A
Sbjct: 1294 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELA 1350
Query: 1105 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1164
++ F+ LP K + + G LS GQ+Q + +ARAL+R+ +IL+LDEAT+A+D E++
Sbjct: 1351 HLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD 1410
Query: 1165 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
++Q + E T + IAHRL+TI + ++V G ++E+G LL Q+G+++SM
Sbjct: 1411 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1468
Score = 137 bits (345), Expect = 6e-32
Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)
Query: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 937 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 994
Query: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 995 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1053
Query: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 1054 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1109
Query: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 1110 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1164
Query: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
S+ ++V +S+ + + + N A + + + + +
Sbjct: 1165 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1223
Query: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 1224 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1282
Query: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 1283 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1341
Query: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
E+ +++ A+ +F+ LP K D E G LS GQ+Q + +ARAL+R KIL+LDEAT
Sbjct: 1342 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1401
Query: 561 SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
+A+D E++ +Q+ + E T + IAHRL+T+ + + + G I E G+ S+L+++
Sbjct: 1402 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1461
Query: 621 EGVYFKL 627
G+++ +
Sbjct: 1462 RGLFYSM 1468
Score = 65.5 bits (158), Expect = 3e-10
Identities = 61/267 (22%), Positives = 104/267 (38%), Gaps = 80/267 (29%)
Query: 974 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1023
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 1024 SGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1083
GCGKS+++ L D + G V + G A V Q+ + + S+ ENI
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAIKGSVA-------------YVPQQAWIQNDSLRENI 726
Query: 1084 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1143
+G + + S +A + P +E LP T + G+K RI + ++
Sbjct: 727 LFGCQ---LEEPYYRSVIQACALLPDLEILPSGDRTEI---------GEKTRILVTHSMS 774
Query: 1144 RQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV 1203
PQ+ D+I+V G++
Sbjct: 775 YLPQV--------------------------------------------DVIIVMSGGKI 790
Query: 1204 KEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
E G++Q+LLA+ G + + A T+
Sbjct: 791 SEMGSYQELLARDGAFAEFLRTYASTE 817
Score = 52.8 bits (125), Expect = 2e-06
Identities = 56/264 (21%), Positives = 97/264 (36%), Gaps = 68/264 (25%)
Query: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
+ + D EG + I G + V Q+ + + ++ ENI +
Sbjct: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILF----- 728
Query: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
G QL + + A AL+ + +IL
Sbjct: 729 --------------------------------GCQLEEPYYRSVIQACALLPDLEILPSG 756
Query: 558 EATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSEL 617
+ T + +T I++ H +S + DVI G I E GS+ EL
Sbjct: 757 DRTEIGE-----------------KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQEL 799
Query: 618 MKKEGVYFKLVNMQTSGSQIQSEE 641
+ ++G + + + S Q Q E
Sbjct: 800 LARDGAFAEFLRTYASTEQEQDAE 823
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 144 bits (364), Expect = 4e-34
Identities = 76/238 (31%), Positives = 138/238 (57%), Gaps = 4/238 (1%)
Query: 985 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1044
G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R + G
Sbjct: 1176 GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1234
Query: 1045 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1104
+++DG K+ + LR ++ I+ Q+P+LF S+ N+ D S +E+ ++ + A
Sbjct: 1235 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELA 1291
Query: 1105 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1164
++ F+ LP K + + G LS GQ+Q + +ARAL+R+ +IL+LDEAT+A+D E++
Sbjct: 1292 HLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD 1351
Query: 1165 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
++Q + E T + IAHRL+TI + ++V G ++E+G LL Q+G+++SM
Sbjct: 1352 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1409
Score = 137 bits (345), Expect = 6e-32
Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)
Query: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 878 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 935
Query: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 936 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 994
Query: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 995 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1050
Query: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 1051 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1105
Query: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
S+ ++V +S+ + + + N A + + + + +
Sbjct: 1106 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1164
Query: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 1165 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
Query: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1282
Query: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
E+ +++ A+ +F+ LP K D E G LS GQ+Q + +ARAL+R KIL+LDEAT
Sbjct: 1283 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1342
Query: 561 SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
+A+D E++ +Q+ + E T + IAHRL+T+ + + + G I E G+ S+L+++
Sbjct: 1343 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
Query: 621 EGVYFKL 627
G+++ +
Sbjct: 1403 RGLFYSM 1409
Score = 45.1 bits (105), Expect = 4e-04
Identities = 24/75 (32%), Positives = 40/75 (53%), Gaps = 5/75 (6%)
Query: 1156 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1215
SAL E +KV K R I++ H +S + D+I+V G++ E G++Q+LLA+
Sbjct: 689 SALLAEMDKVEGHVAIKTR-----ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
Query: 1216 KGIYFSMVSVQAGTQ 1230
G + + A T+
Sbjct: 744 DGAFAEFLRTYASTE 758
Score = 43.9 bits (102), Expect = 0.001
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 11/85 (12%)
Query: 974 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1023
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 1024 SGCGKSTVVQLLERFYDPLAGTVLL 1048
GCGKS+++ L D + G V +
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAI 704
Score = 41.2 bits (95), Expect = 0.006
Identities = 24/94 (25%), Positives = 46/94 (48%), Gaps = 1/94 (1%)
Query: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREI 471
+ + D EG + I + + +++YL ++
Sbjct: 687 LLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720
Score = 39.3 bits (90), Expect = 0.023
Identities = 19/60 (31%), Positives = 31/60 (51%)
Query: 582 RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEE 641
+T I++ H +S + DVI G I E GS+ EL+ ++G + + + S Q Q E
Sbjct: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 144 bits (364), Expect = 4e-34
Identities = 76/238 (31%), Positives = 138/238 (57%), Gaps = 4/238 (1%)
Query: 985 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1044
G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R + G
Sbjct: 1232 GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1290
Query: 1045 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1104
+++DG K+ + LR ++ I+ Q+P+LF S+ N+ D S +E+ ++ + A
Sbjct: 1291 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELA 1347
Query: 1105 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1164
++ F+ LP K + + G LS GQ+Q + +ARAL+R+ +IL+LDEAT+A+D E++
Sbjct: 1348 HLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD 1407
Query: 1165 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
++Q + E T + IAHRL+TI + ++V G ++E+G LL Q+G+++SM
Sbjct: 1408 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1465
Score = 137 bits (345), Expect = 6e-32
Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)
Query: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 934 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 991
Query: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 992 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1050
Query: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 1051 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1106
Query: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 1107 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1161
Query: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
S+ ++V +S+ + + + N A + + + + +
Sbjct: 1162 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1220
Query: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 1221 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1279
Query: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 1280 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1338
Query: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
E+ +++ A+ +F+ LP K D E G LS GQ+Q + +ARAL+R KIL+LDEAT
Sbjct: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398
Query: 561 SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
+A+D E++ +Q+ + E T + IAHRL+T+ + + + G I E G+ S+L+++
Sbjct: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
Query: 621 EGVYFKL 627
G+++ +
Sbjct: 1459 RGLFYSM 1465
Score = 77.4 bits (189), Expect = 8e-14
Identities = 41/118 (34%), Positives = 67/118 (56%), Gaps = 3/118 (2%)
Query: 1116 KYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAR- 1174
K E V KG LSGGQKQR+++ARA+ I L D+ SA+D K + E + +
Sbjct: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
Query: 1175 --EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
+ +T I++ H +S + D+I+V G++ E G++Q+LLA+ G + + A T+
Sbjct: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 814
Score = 68.6 bits (166), Expect = 4e-11
Identities = 40/124 (32%), Positives = 64/124 (51%), Gaps = 3/124 (2%)
Query: 521 KFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAR- 579
K + V +G LSGGQKQR+++ARA+ N I L D+ SA+D + + +
Sbjct: 697 KVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKG 756
Query: 580 --EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQI 637
+ +T I++ H +S + DVI G I E GS+ EL+ ++G + + + S Q
Sbjct: 757 MLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQE 816
Query: 638 QSEE 641
Q E
Sbjct: 817 QDAE 820
Score = 39.7 bits (91), Expect = 0.018
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 1/83 (1%)
Query: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 438 TVQLIQRLYDPDEGTINIDGQDI 460
+ + D EG + I G ++
Sbjct: 687 LLSALLAEMDKVEGHVAIKGVNL 709
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 144 bits (364), Expect = 4e-34
Identities = 76/238 (31%), Positives = 138/238 (57%), Gaps = 4/238 (1%)
Query: 985 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1044
G + F Y + VL+ +++ + G+ + +VG +G GKS++ L R + G
Sbjct: 1291 GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEG 1349
Query: 1045 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1104
+++DG K+ + LR ++ I+ Q+P+LF S+ N+ D S +E+ ++ + A
Sbjct: 1350 EIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELA 1406
Query: 1105 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1164
++ F+ LP K + + G LS GQ+Q + +ARAL+R+ +IL+LDEAT+A+D E++
Sbjct: 1407 HLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDD 1466
Query: 1165 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
++Q + E T + IAHRL+TI + ++V G ++E+G LL Q+G+++SM
Sbjct: 1467 LIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1524
Score = 137 bits (345), Expect = 6e-32
Identities = 139/547 (25%), Positives = 253/547 (46%), Gaps = 31/547 (5%)
Query: 97 NFSLSLLNPGKIL----EEEMTRYAYYYS-GLGAGVLVAAY-IQVSFWTLAAGRQIRKIR 150
N+ LSL I+ E R + Y + G+ G+ V Y + VS + A R +
Sbjct: 993 NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHV-- 1050
Query: 151 QKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGF 210
H+ILR + +F+ + L R + ++ + I + + MF ++ IV
Sbjct: 1051 -DLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVIL 1109
Query: 211 IRGWKLTLVIMAISPILGLSAAVWAKILSAFSD--KELAAYAKAGAVAE--EALGAIRTV 266
+ T + I P LGL + A S K L + +++ + E L + +
Sbjct: 1110 LA----TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1165
Query: 267 IAFGGQNKELERYQKHLENAKEIGIKKAISANI--SMGIAFLLIYASYALAFWYGSTLVI 324
AF +E ER+ H + K +KA +I + +A L + + VI
Sbjct: 1166 RAF----EEQERFI-HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVI 1220
Query: 325 SKEYTIGN--AMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSE 382
S+ ++V +S+ + + + N A + + + + +
Sbjct: 1221 SRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV-AVERLKEYSETEKEAPWQIQ 1279
Query: 383 RGHKPDSIK--GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQ 440
P S G +EF + Y + +L+ +N+ + G+ V +VG +G GKS+
Sbjct: 1280 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1338
Query: 441 LIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMD 500
+ R+ + EG I IDG +I ++ LR I ++ Q+PVLFS ++ N+ + +
Sbjct: 1339 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDE 1397
Query: 501 EIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 560
E+ +++ A+ +F+ LP K D E G LS GQ+Q + +ARAL+R KIL+LDEAT
Sbjct: 1398 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1457
Query: 561 SALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKK 620
+A+D E++ +Q+ + E T + IAHRL+T+ + + + G I E G+ S+L+++
Sbjct: 1458 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1517
Query: 621 EGVYFKL 627
G+++ +
Sbjct: 1518 RGLFYSM 1524
Score = 124 bits (311), Expect = 6e-28
Identities = 81/270 (30%), Positives = 132/270 (48%), Gaps = 30/270 (11%)
Query: 974 SEEGLKPDKFE----------GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGS 1023
S E L+PD E +IT F + R++ P L G++ + +G +A+VG
Sbjct: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
Query: 1024 SGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENI 1083
GCGKS+++ L D + G V + G A W++ +E ILF C + E
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDS---LRENILFGCQLEEPY 736
Query: 1084 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1143
S +A + P +E LP T +G+KG LSGGQKQR+++ARA+
Sbjct: 737 YR-------------SVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVY 783
Query: 1144 RQPQILLLDEATSALDTESEKVVQEALDKAR---EGRTCIVIAHRLSTIQNADLIVVFQN 1200
I L D+ SA+D K + E + + + +T I++ H +S + D+I+V
Sbjct: 784 SNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 843
Query: 1201 GRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
G++ E G++Q+LLA+ G + + A T+
Sbjct: 844 GKISEMGSYQELLARDGAFAEFLRTYASTE 873
Score = 102 bits (255), Expect = 2e-21
Identities = 72/267 (26%), Positives = 123/267 (46%), Gaps = 18/267 (6%)
Query: 378 DSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKST 437
DS R K ++ + F++ +R++ L G+ + G VA+VG GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 438 TVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNV 497
+ + D EG + I G + V Q+ + + ++ ENI +G +
Sbjct: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGC-QL 732
Query: 498 TMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 557
+ ++ + LP T +GE+G LSGGQKQR+++ARA+ N I L D
Sbjct: 733 EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFD 792
Query: 558 EATSALDTESEAEVQAALDKAR---EGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSH 614
+ SA+D + + + + +T I++ H +S + DVI G I E GS+
Sbjct: 793 DPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSY 852
Query: 615 SELMKKEGVYFKLVNMQTSGSQIQSEE 641
EL+ ++G + + + S Q Q E
Sbjct: 853 QELLARDGAFAEFLRTYASTEQEQDAE 879
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 143 bits (361), Expect = 9e-34
Identities = 82/241 (34%), Positives = 137/241 (56%), Gaps = 5/241 (2%)
Query: 984 EGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043
EG I +++ Y PVL+ + +K GQ + + G +G GKS++ R D
Sbjct: 1309 EGEIKIHDLCVRYENNLK-PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFD 1367
Query: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
G +++DG + KL + LR++L I+ Q+PILF SI N+ D + D + A +
Sbjct: 1368 GKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEI 1424
Query: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
A + +++LP + V + G S GQ+Q +ARA +R+ IL++DEAT+++D +E
Sbjct: 1425 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1484
Query: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSM 1222
++Q+ + A RT + IAHR+ TI ADL++V + G + E+ T + LLAQ+ G++ S
Sbjct: 1485 NILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASF 1544
Query: 1223 V 1223
V
Sbjct: 1545 V 1545
Score = 122 bits (307), Expect = 2e-27
Identities = 79/240 (32%), Positives = 131/240 (54%), Gaps = 5/240 (2%)
Query: 391 KGNLEFNDVHFSYPSRANVK-ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
+G ++ +D+ Y + N+K +LK + ++ GQ V + G +G GKS+ R+ D
Sbjct: 1309 EGEIKIHDLCVRYEN--NLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIF 1366
Query: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
+G I IDG DI ++ LR + ++ Q+P+LFS +I N+ T D + +A++ A
Sbjct: 1367 DGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-PECKCTDDRLWEALEIA 1425
Query: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
+ LP D +V E G S GQ+Q +ARA VR IL++DEAT+++D +E
Sbjct: 1426 QLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATEN 1485
Query: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKE-GVYFKLV 628
+Q + A RT + IAHR+ T+ AD++ + G I+E + L+ +E GV+ V
Sbjct: 1486 ILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545
Score = 106 bits (264), Expect = 2e-22
Identities = 71/248 (28%), Positives = 127/248 (51%), Gaps = 13/248 (5%)
Query: 970 IDSY--SEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCG 1027
+DSY S L+P + E +I + + + L + + + GQ +VG GCG
Sbjct: 652 LDSYEQSTRRLRPAETE-DIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCG 710
Query: 1028 KSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQ----LGIVSQEPILFDCSIAENI 1083
KS+++ + L G V + + + R++ + +Q+P L + ++ ENI
Sbjct: 711 KSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENI 770
Query: 1084 AYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALI 1143
+G ++ + A ++ P I+ LP +T +G++G LSGGQ+QRI +ARAL
Sbjct: 771 TFGSP---FNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 827
Query: 1144 RQPQILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQNADLIVVFQN 1200
+ I+ LD+ SALD S+ ++QE + K + RT +++ H+L + +AD I+ ++
Sbjct: 828 QNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKD 887
Query: 1201 GRVKEHGT 1208
G V GT
Sbjct: 888 GSVLREGT 895
Score = 105 bits (262), Expect = 3e-22
Identities = 93/345 (26%), Positives = 166/345 (48%), Gaps = 27/345 (7%)
Query: 400 HFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDG-- 457
+FS+ S + L +++++ +GQ +VG GCGKS+ + I EG ++
Sbjct: 678 YFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVN 735
Query: 458 QDIRNFNVNYLREIIGVV--SQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYE-F 514
+ +F R V +Q+P L + T+ ENI +G + + KAV +A + +
Sbjct: 736 ESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQPD 793
Query: 515 IMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQA 573
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ +Q
Sbjct: 794 IDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQE 853
Query: 574 ALDK--AREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
+ K + RT +++ H+L + +AD I +DG ++ +G+ ++ K+ +L
Sbjct: 854 GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKD---VELYEHW 910
Query: 632 TSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEAN 691
+ Q +E E + E T + + ++ + +++ ++ + E D N
Sbjct: 911 KTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDD----N 966
Query: 692 VPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEII 736
+ V L+ KT W Y + +GG +IFS+++
Sbjct: 967 MSTVMRLRTKMPWKTCWRY--------LTSGGFFLLILMIFSKLL 1003
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 140 bits (354), Expect = 6e-33
Identities = 81/239 (33%), Positives = 139/239 (58%), Gaps = 6/239 (2%)
Query: 985 GNITFNEVVFNYPTRANVPV-LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043
G I F + Y R +P+ +QG+S ++ G+ + +VG +G GKS++ L R +
Sbjct: 1263 GQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE 1320
Query: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
G + +DG + + LR+++ I+ Q+PILF S+ N+ D + S + I +A +
Sbjct: 1321 GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIWAALET 1377
Query: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
+ + +LP + + + D+G LS GQKQ + +ARAL+R+ QIL+LDEAT+A+D +E
Sbjct: 1378 VQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTE 1437
Query: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
+Q L T ++IAHRL ++ + ++V G+V E G+ QLLAQKG+++ +
Sbjct: 1438 LQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
Score = 132 bits (333), Expect = 2e-30
Identities = 129/522 (24%), Positives = 239/522 (45%), Gaps = 24/522 (4%)
Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
LG + + ++ L R R + Q+ ++R I +F+ L R + +
Sbjct: 994 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 1053
Query: 183 KISEGIGDKVGMFFQAVATFFAGFI-VGFIRGWKLTLVIMAISPILGLSAAVWAK-ILSA 240
+ I DK+ +++ + G + V + L +AI P+ L A + ++S+
Sbjct: 1054 TVDVDIPDKL----RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109
Query: 241 FSDKEL--AAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISAN 298
+ L A+Y+ + E V AF Q + + ++ ++ I + ++
Sbjct: 1110 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR 1169
Query: 299 ISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFA 358
LL L F + V+SK + +A V FS+ A V Q +
Sbjct: 1170 WLAANVELL---GNGLVFAAATCAVLSKAHL--SAGLVGFSVS-AALQVTQTLQWVVRNW 1223
Query: 359 NARGAAYVIFDIIDN---NPKIDSF---SERGHKPDSIKGNLEFNDVHFSYPSRANVKIL 412
+ V + + + PK + + P G +EF D Y + +
Sbjct: 1224 TDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAV- 1282
Query: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
+G++ K+ +G+ V +VG +G GKS+ + RL + EG I IDG I + ++ LR I
Sbjct: 1283 QGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRI 1342
Query: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQ 532
++ Q+P+LF ++ N+ + + + + I A++ + LP + +RG
Sbjct: 1343 SIIPQDPILFPGSLRMNLDLLQEH-SDEAIWAALETVQLKALVASLPGQLQYKCADRGED 1401
Query: 533 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLS 592
LS GQKQ + +ARAL+R +IL+LDEAT+A+D +E ++QA L T ++IAHRL
Sbjct: 1402 LSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLR 1461
Query: 593 TVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSG 634
+V + + + G + E GS ++L+ ++G++++L Q SG
Sbjct: 1462 SVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLA--QESG 1501
Score = 110 bits (274), Expect = 1e-23
Identities = 71/234 (30%), Positives = 122/234 (52%), Gaps = 20/234 (8%)
Query: 987 ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV 1046
IT + F + ++ + P L ++L V +G LA+VG G GKS+++ L + G V
Sbjct: 629 ITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV 687
Query: 1047 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1106
++G A V QE + + S+ EN+ +G + + +A +
Sbjct: 688 SIEGAVA-------------YVPQEAWVQNTSVVENVCFGQE---LDPPWLERVLEACAL 731
Query: 1107 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTE-SEKV 1165
P +++ P T +G++G LSGGQKQR+++ARA+ R+ + LLD+ +ALD + V
Sbjct: 732 QPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHV 791
Query: 1166 VQEALDKA--REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1217
+ + +G T I++ H L + AD I+V NG + E G++Q+LL +KG
Sbjct: 792 FNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG 845
Score = 102 bits (253), Expect = 3e-21
Identities = 73/270 (27%), Positives = 126/270 (46%), Gaps = 17/270 (6%)
Query: 405 SRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFN 464
S+ + L +NL V G +A+VG G GKS+ + + EG ++I+G
Sbjct: 639 SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------ 692
Query: 465 VNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDT 524
+ V QE + +T++ EN+C+G+ + +++ ++ + P+ T
Sbjct: 693 -------VAYVPQEAWVQNTSVVENVCFGQ-ELDPPWLERVLEACALQPDVDSFPEGIHT 744
Query: 525 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL---DKAREG 581
+GE+G LSGGQKQR+++ARA+ R + LLD+ +ALD V + +G
Sbjct: 745 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQG 804
Query: 582 RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEE 641
T I++ H L + AD I +G I E GS+ EL++++G L++ E
Sbjct: 805 TTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGE 864
Query: 642 FELNDEKAATRMAPNGWKSRLFRHSTQKNL 671
E R G + L R + K++
Sbjct: 865 TEPGTSTKDPRGTSAGRRPELRRERSIKSV 894
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 140 bits (354), Expect = 6e-33
Identities = 81/239 (33%), Positives = 139/239 (58%), Gaps = 6/239 (2%)
Query: 985 GNITFNEVVFNYPTRANVPV-LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA 1043
G I F + Y R +P+ +QG+S ++ G+ + +VG +G GKS++ L R +
Sbjct: 1072 GQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAE 1129
Query: 1044 GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1103
G + +DG + + LR+++ I+ Q+PILF S+ N+ D + S + I +A +
Sbjct: 1130 GGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQEHSDEAIWAALET 1186
Query: 1104 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1163
+ + +LP + + + D+G LS GQKQ + +ARAL+R+ QIL+LDEAT+A+D +E
Sbjct: 1187 VQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTE 1246
Query: 1164 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1222
+Q L T ++IAHRL ++ + ++V G+V E G+ QLLAQKG+++ +
Sbjct: 1247 LQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1305
Score = 132 bits (333), Expect = 2e-30
Identities = 129/522 (24%), Positives = 239/522 (45%), Gaps = 24/522 (4%)
Query: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
LG + + ++ L R R + Q+ ++R I +F+ L R + +
Sbjct: 803 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 862
Query: 183 KISEGIGDKVGMFFQAVATFFAGFI-VGFIRGWKLTLVIMAISPILGLSAAVWAK-ILSA 240
+ I DK+ +++ + G + V + L +AI P+ L A + ++S+
Sbjct: 863 TVDVDIPDKL----RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 918
Query: 241 FSDKEL--AAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISAN 298
+ L A+Y+ + E V AF Q + + ++ ++ I + ++
Sbjct: 919 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR 978
Query: 299 ISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFA 358
LL L F + V+SK + +A V FS+ A V Q +
Sbjct: 979 WLAANVELL---GNGLVFAAATCAVLSKAHL--SAGLVGFSVS-AALQVTQTLQWVVRNW 1032
Query: 359 NARGAAYVIFDIIDN---NPKIDSF---SERGHKPDSIKGNLEFNDVHFSYPSRANVKIL 412
+ V + + + PK + + P G +EF D Y + +
Sbjct: 1033 TDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFQDFGLRYRPELPLAV- 1091
Query: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
+G++ K+ +G+ V +VG +G GKS+ + RL + EG I IDG I + ++ LR I
Sbjct: 1092 QGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRI 1151
Query: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQ 532
++ Q+P+LF ++ N+ + + + + I A++ + LP + +RG
Sbjct: 1152 SIIPQDPILFPGSLRMNLDLLQEH-SDEAIWAALETVQLKALVASLPGQLQYKCADRGED 1210
Query: 533 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLS 592
LS GQKQ + +ARAL+R +IL+LDEAT+A+D +E ++QA L T ++IAHRL
Sbjct: 1211 LSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLR 1270
Query: 593 TVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSG 634
+V + + + G + E GS ++L+ ++G++++L Q SG
Sbjct: 1271 SVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLA--QESG 1310
Score = 109 bits (273), Expect = 1e-23
Identities = 71/234 (30%), Positives = 121/234 (51%), Gaps = 20/234 (8%)
Query: 987 ITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV 1046
IT F + ++ + P L ++L V +G LA+VG G GKS+++ L + G V
Sbjct: 438 ITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV 496
Query: 1047 LLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANI 1106
++G A V QE + + S+ EN+ +G + + +A +
Sbjct: 497 SIEGAVA-------------YVPQEAWVQNTSVVENVCFGQE---LDPPWLERVLEACAL 540
Query: 1107 HPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTE-SEKV 1165
P +++ P T +G++G LSGGQKQR+++ARA+ R+ + LLD+ +ALD + V
Sbjct: 541 QPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHV 600
Query: 1166 VQEALDKA--REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1217
+ + +G T I++ H L + AD I+V NG + E G++Q+LL +KG
Sbjct: 601 FNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKG 654
Score = 102 bits (253), Expect = 3e-21
Identities = 73/270 (27%), Positives = 126/270 (46%), Gaps = 17/270 (6%)
Query: 405 SRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFN 464
S+ + L +NL V G +A+VG G GKS+ + + EG ++I+G
Sbjct: 448 SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------ 501
Query: 465 VNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDT 524
+ V QE + +T++ EN+C+G+ + +++ ++ + P+ T
Sbjct: 502 -------VAYVPQEAWVQNTSVVENVCFGQ-ELDPPWLERVLEACALQPDVDSFPEGIHT 553
Query: 525 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL---DKAREG 581
+GE+G LSGGQKQR+++ARA+ R + LLD+ +ALD V + +G
Sbjct: 554 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQG 613
Query: 582 RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEE 641
T I++ H L + AD I +G I E GS+ EL++++G L++ E
Sbjct: 614 TTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGEGE 673
Query: 642 FELNDEKAATRMAPNGWKSRLFRHSTQKNL 671
E R G + L R + K++
Sbjct: 674 TEPGTSTKDPRGTSAGRRPELRRERSIKSV 703
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 140 bits (354), Expect = 6e-33
Identities = 88/253 (34%), Positives = 148/253 (58%), Gaps = 20/253 (7%)
Query: 984 EGNITFNEVVFNYPTRANVP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPL 1042
+G + F +VV Y R +P L G++ V+ G+ L +VG +G GKS+++ +L R +P
Sbjct: 1215 QGGVEFQDVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPS 1272
Query: 1043 AGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAK 1102
+G VLLDG + +L + LR+QL I+ QEP LF ++ EN+ D + + A K
Sbjct: 1273 SGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENL---DPQGLHKDRALWQALK 1329
Query: 1103 AANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1162
++ I ++ + +G+ G LS GQ+Q + +ARAL+ +IL +DEAT+++D ++
Sbjct: 1330 QCHLSEVITSMGG-LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT 1388
Query: 1163 EKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE-----------HGTHQQ 1211
++++Q+ + K +T + IAHRL+TI N+D ++V Q GRV E H QQ
Sbjct: 1389 DQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQ 1448
Query: 1212 LL--AQKGIYFSM 1222
LL +Q+G+ S+
Sbjct: 1449 LLQSSQQGVPASL 1461
Score = 128 bits (322), Expect = 3e-29
Identities = 80/237 (33%), Positives = 134/237 (56%), Gaps = 5/237 (2%)
Query: 391 KGNLEFNDVHFSY-PSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPD 449
+G +EF DV +Y P N L G+ VQ G+ + +VG +G GKS+ + ++ RL +P
Sbjct: 1215 QGGVEFQDVVLAYRPGLPNA--LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPS 1272
Query: 450 EGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEA 509
G + +DG D + LR + ++ QEP LFS T+ EN+ +G + +A+K+
Sbjct: 1273 SGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD-PQGLHKDRALWQALKQC 1331
Query: 510 NAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 569
+ E I + D +GE G LS GQ+Q + +ARAL+ + KIL +DEAT+++D +++
Sbjct: 1332 HLSEVITSMGG-LDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQ 1390
Query: 570 EVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFK 626
+Q + K +T + IAHRL+T+ N+D + + G +VE S + L + F+
Sbjct: 1391 LLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQ 1447
Score = 95.1 bits (235), Expect = 4e-19
Identities = 60/205 (29%), Positives = 106/205 (51%), Gaps = 14/205 (6%)
Query: 1010 LEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVS 1069
LEVKKG + +VG GCGKS+++ + L G V + G L G+ +
Sbjct: 593 LEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLAT 642
Query: 1070 QEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLS 1129
QEP + +I +NI +G E++ A ++ + LP +T VG+KG LS
Sbjct: 643 QEPWIQFATIRDNILFGKTFDAQLYKEVLEACA---LNDDLSILPAGDQTEVGEKGVTLS 699
Query: 1130 GGQKQRIAIARALIRQPQILLLDEATSALDTE-SEKVVQEALDKAREGRTCIVIAHRLST 1188
GGQ+ RIA+ARA+ ++ ++ LLD+ +A+D + + ++ + T ++ HR
Sbjct: 700 GGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEY 759
Query: 1189 IQNADLIVVFQNGRVKEHGTHQQLL 1213
++ AD +++ + GR+ G ++L
Sbjct: 760 LERADAVLLMEAGRLIRAGPPSEIL 784
Score = 87.8 bits (216), Expect = 6e-17
Identities = 141/574 (24%), Positives = 244/574 (42%), Gaps = 77/574 (13%)
Query: 84 KFVDTAGNFSFPVNFSL--SLLNPGKILEEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLA 141
K V T FS P+ SL L G +E ++ Y GL G ++ A +Q +
Sbjct: 249 KLVGTMLGFSGPLLLSLLVGFLEEG---QEPLSHGLLYALGLAGGAVLGAVLQNQY---- 301
Query: 142 AGRQIRKIRQKFFHAILR------QEIGWFDINDTTELNTRLTDD--ISKISEGIGDKVG 193
G ++ K+ + A+L ++G LN TD + + + G
Sbjct: 302 -GYEVYKVTLQARGAVLNILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWG 360
Query: 194 MFFQAVATFFAGFI---VGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYA 250
+ Q T + + V F+ G L L+++ ++ ++ +I++ S++E+ +
Sbjct: 361 LPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIA------TRIMA--SNQEMLQHK 412
Query: 251 KAGA-VAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG----IKKAISANISMGIAF 305
A + E L IR VI F G + L + A+E+G IK +A + + A
Sbjct: 413 DARVKLVTELLSGIR-VIKFCGWEQALGARVEACR-ARELGRLRVIKYLDAACVYLWAAL 470
Query: 306 -----LLIYASYALAFWYGSTLVISKEYT-----------IGNAMTVFFSILIGAFSVGQ 349
++I+ +Y L G L +K +T + N V +L S+ +
Sbjct: 471 PVVISIVIFITYVLM---GHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDR 527
Query: 350 AAPCIDAFANARGAAYVIFDIIDNNPKIDSF--SERGHKPDSIKGNLEFNDVHFSYPSRA 407
+D N AY D +I S+ +P ++ LE + FS+
Sbjct: 528 IQLFLD-LPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTV---LELHGALFSWDPVG 583
Query: 408 NVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNY 467
+L+V+ G V +VG GCGKS+ + I G + + G
Sbjct: 584 TSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG---------- 633
Query: 468 LREIIGVVSQEPVLFSTTIAENICYGRGNVTMD-EIKKAVKEANAY-EFIMKLPQKFDTL 525
L + G+ +QEP + TI +NI +G+ T D ++ K V EA A + + LP T
Sbjct: 634 LSKGFGLATQEPWIQFATIRDNILFGK---TFDAQLYKEVLEACALNDDLSILPAGDQTE 690
Query: 526 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAEVQAALDKAREGRTT 584
VGE+G LSGGQ+ RIA+ARA+ + ++ LLD+ +A+D + + + + T
Sbjct: 691 VGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR 750
Query: 585 IVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELM 618
++ HR + AD + E G ++ G SE++
Sbjct: 751 LLCTHRTEYLERADAVLLMEAGRLIRAGPPSEIL 784
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,942,565
Number of Sequences: 37866
Number of extensions: 1548864
Number of successful extensions: 4605
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 3953
Number of HSP's gapped (non-prelim): 345
length of query: 1232
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1118
effective length of database: 13,930,794
effective search space: 15574627692
effective search space used: 15574627692
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.