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Search of human proteins with 8923516
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8923516 ankyrin repeat and SOCS box-containing 6 isoform 1
[Homo sapiens]
(421 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8923516 ankyrin repeat and SOCS box-containing 6 isoform 1 [H... 852 0.0
gi|30089932 ankyrin repeat and SOCS box-containing 6 isoform 2 [... 267 1e-71
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 79 8e-15
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 69 6e-12
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 69 8e-12
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 69 1e-11
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 69 1e-11
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 68 1e-11
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 68 1e-11
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 67 2e-11
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 67 4e-11
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 66 5e-11
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 66 7e-11
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 66 7e-11
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 65 9e-11
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 65 9e-11
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 64 3e-10
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 63 4e-10
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 62 7e-10
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 62 7e-10
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 62 7e-10
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 62 7e-10
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 62 7e-10
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 62 7e-10
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 62 7e-10
gi|10863929 ribonuclease L [Homo sapiens] 62 1e-09
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 62 1e-09
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 62 1e-09
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 62 1e-09
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 62 1e-09
>gi|8923516 ankyrin repeat and SOCS box-containing 6 isoform 1 [Homo
sapiens]
Length = 421
Score = 852 bits (2200), Expect = 0.0
Identities = 421/421 (100%), Positives = 421/421 (100%)
Query: 1 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 60
MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
Sbjct: 1 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 60
Query: 61 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
Sbjct: 61 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
Query: 121 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA 180
LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA
Sbjct: 121 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA 180
Query: 181 SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF 240
SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF
Sbjct: 181 SSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCF 240
Query: 241 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF 300
QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF
Sbjct: 241 QVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGF 300
Query: 301 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA 360
HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA
Sbjct: 301 HIIFERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQA 360
Query: 361 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD 420
LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD
Sbjct: 361 LHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVEDD 420
Query: 421 I 421
I
Sbjct: 421 I 421
>gi|30089932 ankyrin repeat and SOCS box-containing 6 isoform 2
[Homo sapiens]
Length = 197
Score = 267 bits (683), Expect = 1e-71
Identities = 134/134 (100%), Positives = 134/134 (100%)
Query: 1 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 60
MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA
Sbjct: 1 MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKA 60
Query: 61 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE
Sbjct: 61 HSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVE 120
Query: 121 LLVHHGADVNRRDR 134
LLVHHGADVNRRDR
Sbjct: 121 LLVHHGADVNRRDR 134
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 79.0 bits (193), Expect = 8e-15
Identities = 79/288 (27%), Positives = 136/288 (47%), Gaps = 54/288 (18%)
Query: 37 DRPSYVAS------EESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLR 90
D+PS V + +E R L+ +K F L A LG ++L+
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIF-----KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLIL 62
Query: 91 HGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPER 150
GA +N +D + T LH AV + V++L+ H ADVN RD+ + +PL +A+ +
Sbjct: 63 SGARVNAKDS-KWLTPLHRAVASCSEEAVQVLLKHSADVNARDK-NWQTPLHIAAAN-KA 119
Query: 151 LPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDG 210
+ C + L+ L ++VN +D+ G+TAL HA S G E ++LLL GA++ A
Sbjct: 120 VKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHG------EMVKLLLSRGANINAF---- 169
Query: 211 DTVFTCIIFLLGETVGGDKEEAQMINRFCF----QVTRLLLAHGADPSECPAHESLTHIC 266
DK++ + I+ + +V +LL++HGA+ + C +S T +
Sbjct: 170 -----------------DKKDRRAIHWAAYMGHIEVVKLLVSHGAEVT-CKDKKSYTPLH 211
Query: 267 LKSFKLHFPLLRFLLESGA------AY-NCSLHGASCWSGFHIIFERL 307
+ ++++LL+ G AY N LH +C++G ++ L
Sbjct: 212 AAASSGMISVVKYLLDLGVDMNEPNAYGNTPLH-VACYNGQDVVVNEL 258
Score = 50.1 bits (118), Expect = 4e-06
Identities = 42/126 (33%), Positives = 60/126 (47%), Gaps = 9/126 (7%)
Query: 85 ADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA 144
+ +++ GA ++ ED T LHIA ++ L+ GAD +R IH PL LA
Sbjct: 322 SQTIIQSGAVIDCEDK-NGNTPLHIAARYGHELLINTLITSGADTAKRG-IHGMFPLHLA 379
Query: 145 SEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVK 204
+ C ++LL G D++ D G+T LHA A+ N E + LLL GAD
Sbjct: 380 ALSGFS-DCCRKLLSSGFDIDTPDDFGRTC-LHAAAAGG-----NLECLNLLLNTGADFN 432
Query: 205 ATTKDG 210
K G
Sbjct: 433 KKDKFG 438
Score = 49.7 bits (117), Expect = 5e-06
Identities = 43/138 (31%), Positives = 65/138 (47%), Gaps = 12/138 (8%)
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTY-YTALHIAVLRNQPDMVELLVHHGADVNRRDRI 135
A G+ LL G ++N +P Y T LH+A Q +V L+ GA VN+++
Sbjct: 214 ASSGMISVVKYLLDLGVDMN--EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNE- 270
Query: 136 HESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNT-ENIR 194
+PL A+ CL+ L+ GADVN K GKT LH A +H +
Sbjct: 271 KGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTP-LHMTA------LHGRFSRSQ 323
Query: 195 LLLEGGADVKATTKDGDT 212
+++ GA + K+G+T
Sbjct: 324 TIIQSGAVIDCEDKNGNT 341
Score = 43.5 bits (101), Expect = 4e-04
Identities = 44/147 (29%), Positives = 69/147 (46%), Gaps = 8/147 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNAL-LKMAEL-GLTRAADVLLRHGANLN 96
P ++A+ L++ L+ A + + G+ L +A L G + LL G +++
Sbjct: 342 PLHIAARYGHELLINTLITSGADTA--KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDID 399
Query: 97 FEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQR 156
D T LH A + + LL++ GAD N++D+ SPL A+ CL
Sbjct: 400 TPDDFGR-TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGR-SPLHYAAANC-NYQCLFA 456
Query: 157 LLDLGADVNAADKHGKTALLHALASSD 183
L+ GA VN D+ G T LH A+SD
Sbjct: 457 LVGSGASVNDLDERGCTP-LHYAATSD 482
Score = 43.1 bits (100), Expect = 5e-04
Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 9/124 (7%)
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRI--HE 137
G DVL+ GA++ +D + T +H A + + LL+ + N D +
Sbjct: 594 GHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNG 653
Query: 138 SSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLL 197
+PL L S C+ LL+ GA+V+A DK G+TAL G + E + LL
Sbjct: 654 QTPLML-SVLNGHTDCVYSLLNKGANVDAKDKWGRTAL------HRGAVTGHEECVDALL 706
Query: 198 EGGA 201
+ GA
Sbjct: 707 QHGA 710
Score = 38.9 bits (89), Expect = 0.009
Identities = 38/110 (34%), Positives = 49/110 (44%), Gaps = 9/110 (8%)
Query: 104 YTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGAD 163
YTALH A VELL+ +V ++ + SPL A + LGA
Sbjct: 757 YTALHWACYNGHETCVELLLEQ--EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGAS 814
Query: 164 -VNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
VNA D G+T LHA A +D V E ++LLL A V + G T
Sbjct: 815 IVNATDSKGRTP-LHAAAFTDHV-----ECLQLLLSHNAQVNSVDSTGKT 858
Score = 38.1 bits (87), Expect = 0.015
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 9/107 (8%)
Query: 104 YTALHIAVLRNQPDMVELLVHH-GADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGA 162
++ LH AV+ + E+L+ GA + +PL A+ + + CLQ LL A
Sbjct: 789 FSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFT-DHVECLQLLLSHNA 847
Query: 163 DVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKD 209
VN+ D GKT L+ +A+ +G T + +L+ A + T +D
Sbjct: 848 QVNSVDSTGKTPLM--MAAENG----QTNTVEMLV-SSASAELTLQD 887
Score = 36.2 bits (82), Expect = 0.057
Identities = 38/115 (33%), Positives = 53/115 (46%), Gaps = 8/115 (6%)
Query: 66 QEGVSNALLKMAEL-GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVH 124
Q+G L ++ L G T LL GAN++ +D TALH + + V+ L+
Sbjct: 649 QDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGR-TALHRGAVTGHEECVDALLQ 707
Query: 125 HGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNA----ADKHGKTAL 175
HGA RD +P+ L S + L LL A ++A AD HG TAL
Sbjct: 708 HGAKCLLRDS-RGRTPIHL-SAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
Score = 29.6 bits (65), Expect = 5.4
Identities = 27/107 (25%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Query: 17 LVDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKM 76
LV + L +QD + +L E S +L+L ++ +R + + L
Sbjct: 875 LVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINA-TNAALQTPLHVA 933
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLV 123
A GLT LL GA++ D Y AL A ++ D + L++
Sbjct: 934 ARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 69.3 bits (168), Expect = 6e-12
Identities = 77/277 (27%), Positives = 125/277 (45%), Gaps = 48/277 (17%)
Query: 37 DRPSYVASEESR-ILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANL 95
D+P V + SR + + LL +K + + L A +G +LL GAN+
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 96 NFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQ 155
N +D + + T LH A ++ LL+ H ADVN RD++ + +PL +A+ C +
Sbjct: 68 NAKDTL-WLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQ-TPLHVAAAN-RATKCAE 124
Query: 156 RLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFT 215
L L + +N AD+ G++AL HA+ S + E + LLL GA +
Sbjct: 125 ALAPLLSSLNVADRSGRSALHHAVHSG------HLETVNLLLNKGASLNVC--------- 169
Query: 216 CIIFLLGETVGGDKEEAQMINRFCF----QVTRLLLAHGADPSECPAHE--SLTHICLKS 269
DK+E Q ++ F +V +LL+A GAD C + L H S
Sbjct: 170 ------------DKKERQPLHWAAFLGHLEVLKLLVARGADLG-CKDRKGYGLLHTAAAS 216
Query: 270 FKLHFPLLRFLLESGAAY-------NCSLHGASCWSG 299
++ ++++LL GA N +LH +C+ G
Sbjct: 217 GQIE--VVKYLLRMGAEIDEPNAFGNTALH-IACYLG 250
Score = 57.0 bits (136), Expect = 3e-08
Identities = 72/276 (26%), Positives = 116/276 (42%), Gaps = 38/276 (13%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAEL-GLTRAADVLLRHGANLNF 97
P +VA+ + + ELL YQ + L MA + G + +L+++G+ ++
Sbjct: 275 PLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDC 334
Query: 98 EDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA-----SEEPERLP 152
D T LH+A ++ L+ +GAD RR IH+ PL LA S+ +L
Sbjct: 335 ADKFGN-TPLHVAARYGHELLISTLMTNGADTARRG-IHDMFPLHLAVLFGFSDCCRKLL 392
Query: 153 CL------------QRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGG 200
+ +L G D+N D G+T LHA AS N E + LLL G
Sbjct: 393 SSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTC-LHAAASGG-----NVECLNLLLSSG 446
Query: 201 ADVKATTKDGDT---------VFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGA 251
AD++ K G T + C + L+ G ++ + + + + A
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRR-A 505
Query: 252 DPSECPAHESLTHICLKSF--KLHFPLLRFLLESGA 285
+P +H++ LK K F L FLL++GA
Sbjct: 506 EPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGA 541
Score = 51.6 bits (122), Expect = 1e-06
Identities = 56/190 (29%), Positives = 86/190 (45%), Gaps = 14/190 (7%)
Query: 24 SLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTR 83
SL + D + ++ L +++ E VL L+ R A L A G
Sbjct: 165 SLNVCDKKERQPLHWAAFLGHLE----VLKLLVARGADLGCKDRKGYGLLHTAAASGQIE 220
Query: 84 AADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDL 143
LLR GA ++ E TALHIA Q + LV+ GA+VN+ + +PL +
Sbjct: 221 VVKYLLRMGAEID-EPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPND-KGFTPLHV 278
Query: 144 ASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNT-ENIRLLLEGGAD 202
A+ CL+ L++ GADVN K GK+ LH A IH ++L++ G++
Sbjct: 279 AAVSTNGALCLELLVNNGADVNYQSKEGKSP-LHMAA------IHGRFTRSQILIQNGSE 331
Query: 203 VKATTKDGDT 212
+ K G+T
Sbjct: 332 IDCADKFGNT 341
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/139 (28%), Positives = 60/139 (43%), Gaps = 3/139 (2%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A+ L L E + AL E G T +VL HGA+ +
Sbjct: 588 PLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIK 647
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHG--ADVNRRDRIHESSPLDLASEEPERLPCLQR 156
+ +T LH A D + LL+ G AD+ + +PL LA + C+
Sbjct: 648 ERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMN-GHVDCVHL 706
Query: 157 LLDLGADVNAADKHGKTAL 175
LL+ G+ +AAD G+TAL
Sbjct: 707 LLEKGSTADAADLRGRTAL 725
Score = 46.6 bits (109), Expect = 4e-05
Identities = 45/136 (33%), Positives = 67/136 (49%), Gaps = 4/136 (2%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
+ A+ +I V+ LL A + AL LG A L+ GAN+N +
Sbjct: 211 HTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPND 270
Query: 101 VTYYTALHIA-VLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLD 159
+ T LH+A V N +ELLV++GADVN + + SPL +A+ R Q L+
Sbjct: 271 KGF-TPLHVAAVSTNGALCLELLVNNGADVNYQSK-EGKSPLHMAAIHG-RFTRSQILIQ 327
Query: 160 LGADVNAADKHGKTAL 175
G++++ ADK G T L
Sbjct: 328 NGSEIDCADKFGNTPL 343
Score = 43.9 bits (102), Expect = 3e-04
Identities = 45/145 (31%), Positives = 56/145 (38%), Gaps = 33/145 (22%)
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN--------- 130
G ++LL GA+L D T LH A LV GA VN
Sbjct: 434 GNVECLNLLLSSGADLRRRDKFGR-TPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSP 492
Query: 131 ----------RRDRIHESSPLDLASEEP-------ERLPCLQRLLDLGADVNAADKHGKT 173
RR H S D +EP E CL+ LLD GAD + D+ G T
Sbjct: 493 LHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYT 552
Query: 174 ALLHALASSDGVQIHNTENIRLLLE 198
A+ +A A N +N+ LLLE
Sbjct: 553 AVHYAAAYG------NRQNLELLLE 571
Score = 42.7 bits (99), Expect = 6e-04
Identities = 63/238 (26%), Positives = 95/238 (39%), Gaps = 34/238 (14%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVS----NALLKMAELGLTRAADVLLRHGAN 94
P ++AS VL LL+ + GV + + + G ++LL H
Sbjct: 757 PIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPF 816
Query: 95 LNFEDPVTYYTALHIAVLRNQPDMVELLVHH-GAD-VNRRDRIHESSPLDLASEEPERLP 152
E +T LH AV+ NQ E+L+ GA VN RD +PL A+ + +
Sbjct: 817 SYLEG--NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDA-KGRTPLHAAAFA-DNVS 872
Query: 153 CLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
L+ LL A+VNA D G+TAL+ A + + LL G AD+ ++ +T
Sbjct: 873 GLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE-----FLLYRGKADLTVLDENKNT 927
Query: 213 VF---------TCIIFLLGET-----VGGDKEEAQM-----INRFCFQVTRLLLAHGA 251
C + +L ET + QM V + LL+HGA
Sbjct: 928 ALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGA 985
Score = 28.9 bits (63), Expect = 9.2
Identities = 35/165 (21%), Positives = 64/165 (38%), Gaps = 8/165 (4%)
Query: 37 DRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGAN-L 95
D P + + L LL+ A A+ A G + ++LL N L
Sbjct: 518 DEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCL 577
Query: 96 NFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQ 155
+ + LH+A + ++ L +++ RD H+ + E C++
Sbjct: 578 EDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRD--HKGRTALFLATERGSTECVE 635
Query: 156 RLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGG 200
L GA ++ K LHA A+S +T+++ LL++ G
Sbjct: 636 VLTAHGASALIKERKRKWTPLHAAAASG-----HTDSLHLLIDSG 675
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 68.9 bits (167), Expect = 8e-12
Identities = 100/382 (26%), Positives = 154/382 (40%), Gaps = 44/382 (11%)
Query: 57 ERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQP 116
+R S Y+E ++ L A G T +LLR A + TALH A
Sbjct: 89 QRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARP--DSAPGGRTALHEACAAGHT 146
Query: 117 DMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALL 176
V +L+ GAD N D+ PL L P L C + LL GA V+ + + L
Sbjct: 147 ACVHVLLVAGADPNIADQ-DGKRPLHLC-RGPGTLECAELLLRFGARVDGRSEEEEETPL 204
Query: 177 HALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMIN 236
H A V++ + LLL GA A +G T + +++ +A+
Sbjct: 205 HVAARLGHVELAD-----LLLRRGACPDARNAEGWTPLLAACDVRCQSI----TDAEATT 255
Query: 237 RFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYN-------- 288
C Q+ LLL+ GAD ++ + + L + H ++ LL G + N
Sbjct: 256 ARCLQLCSLLLSAGAD-ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHT 314
Query: 289 ---CSLHG---ASCWSGFHIIFERLCSH------PGCTEDESHADLLRKAET---VLDLM 333
C+L G A S H++ L +H PG +L + T ++++
Sbjct: 315 PLHCALQGPAAALAQSPEHVV-RALLNHGAVRVWPGALPK-----VLERWSTCPRTIEVL 368
Query: 334 VTNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVD 393
+ +QLPE +K Q + SL L P L+HL R A+R +L+ +
Sbjct: 369 MNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLE-GSLP 427
Query: 394 VKVKALPLPDRLKWYLLSEHSG 415
+ LPLP RL YL + G
Sbjct: 428 QALPRLPLPPRLLRYLQLDFEG 449
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 68.6 bits (166), Expect = 1e-11
Identities = 92/351 (26%), Positives = 141/351 (40%), Gaps = 36/351 (10%)
Query: 65 YQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVH 124
Y+E ++ L A G T +LLR A + TALH A V +L+
Sbjct: 157 YEEELTTPLHVAASRGHTEVLRLLLRRRARP--DSAPGGRTALHEACAAGHTACVHVLLV 214
Query: 125 HGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDG 184
GAD N D+ PL L P L C + LL GA V+ + + LH A
Sbjct: 215 AGADPNIADQ-DGKRPLHLC-RGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 272
Query: 185 VQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTR 244
V++ + LLL GA A +G T + +++ +A+ C Q+
Sbjct: 273 VELAD-----LLLRRGACPDARNAEGWTPLLAACDVRCQSI----TDAEATTARCLQLCS 323
Query: 245 LLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCSLHGASCWSGFHIIF 304
LLL+ GAD ++ + + L + H ++ LL G + N +G + H
Sbjct: 324 LLLSAGAD-ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH--TPLH--- 377
Query: 305 ERLCSHPGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHFS 364
C A L + E V+ ++ + P G+L +K Q + S
Sbjct: 378 --------CALQGPAAALAQSPEHVVRALLNHGAVRVWP--------GALPKKHQRFYSS 421
Query: 365 LRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSG 415
L L P L+HL R A+R +L+ + + LPLP RL YL + G
Sbjct: 422 LFALVRQPRSLQHLSRCALRSHLE-GSLPQALPRLPLPPRLLRYLQLDFEG 471
Score = 51.6 bits (122), Expect = 1e-06
Identities = 55/184 (29%), Positives = 76/184 (41%), Gaps = 10/184 (5%)
Query: 33 QESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHG 92
+E L P +VA+ VL LL R+A P G AL + G T VLL G
Sbjct: 158 EEELTTPLHVAASRGHTEVLRLLLRRRAR-PDSAPGGRTALHEACAAGHTACVHVLLVAG 216
Query: 93 ANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLP 152
A+ N D LH+ + ELL+ GA V+ R E +PL +A+ +
Sbjct: 217 ADPNIADQ-DGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAA-RLGHVE 274
Query: 153 CLQRLLDLGADVNAADKHGKTALLHA-------LASSDGVQIHNTENIRLLLEGGADVKA 205
LL GA +A + G T LL A + ++ + LLL GAD A
Sbjct: 275 LADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADA 334
Query: 206 TTKD 209
+D
Sbjct: 335 ADQD 338
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 68.6 bits (166), Expect = 1e-11
Identities = 98/374 (26%), Positives = 151/374 (40%), Gaps = 44/374 (11%)
Query: 65 YQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVH 124
Y+E ++ L A G T +LLR A + TALH A V +L+
Sbjct: 157 YEEELTTPLHVAASRGHTEVLRLLLRRRARP--DSAPGGRTALHEACAAGHTACVHVLLV 214
Query: 125 HGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDG 184
GAD N D+ PL L P L C + LL GA V+ + + LH A
Sbjct: 215 AGADPNIADQ-DGKRPLHLC-RGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 272
Query: 185 VQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTR 244
V++ + LLL GA A +G T + +++ +A+ C Q+
Sbjct: 273 VELAD-----LLLRRGACPDARNAEGWTPLLAACDVRCQSI----TDAEATTARCLQLCS 323
Query: 245 LLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYN-----------CSLHG 293
LLL+ GAD ++ + + L + H ++ LL G + N C+L G
Sbjct: 324 LLLSAGAD-ADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQG 382
Query: 294 ---ASCWSGFHIIFERLCSH------PGCTEDESHADLLRKAET---VLDLMVTNSQKLQ 341
A S H++ L +H PG +L + T +++++ +Q
Sbjct: 383 PAAALAQSPEHVV-RALLNHGAVRVWPGALPK-----VLERWSTCPRTIEVLMNTYSVVQ 436
Query: 342 LPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPL 401
LPE +K Q + SL L P L+HL R A+R +L+ + + LPL
Sbjct: 437 LPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLE-GSLPQALPRLPL 495
Query: 402 PDRLKWYLLSEHSG 415
P RL YL + G
Sbjct: 496 PPRLLRYLQLDFEG 509
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 68.2 bits (165), Expect = 1e-11
Identities = 70/254 (27%), Positives = 117/254 (46%), Gaps = 28/254 (11%)
Query: 18 VDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMA 77
V +L G Q +S + P +A+ + + L+ER A+ + L++ A
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 78 ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHE 137
G +LL GAN+N + T TAL +A ++ + L+ GAD+ +
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGC 535
Query: 138 SSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLL 197
S+PL AS+E L ++ LL GA+V+A G TAL +A + +T+ +LL
Sbjct: 536 STPLMEASQE-GHLELVKYLLASGANVHATTATGDTALTYACENG------HTDVADVLL 588
Query: 198 EGGADVKATTKDGDTVF--------TCII-FLLGETVGGDKEEAQ----MINRFC----F 240
+ GAD++ ++ G T C + FL+ + ++ A +++ C
Sbjct: 589 QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648
Query: 241 QVTRLLLAHGADPS 254
V LLLAHGADP+
Sbjct: 649 AVVELLLAHGADPT 662
Score = 55.5 bits (132), Expect = 9e-08
Identities = 47/138 (34%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-P 100
+A + R V++ LL+RKA+ + L++ A G VLL GA++N P
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDL 160
+ TAL IA + ELL+H GA ++ R++ ++PL LAS +Q L+
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNK-KGNTPLWLAS-NGGHFDVVQLLVQA 1347
Query: 161 GADVNAADKHGKTALLHA 178
GADV+AAD T L+ A
Sbjct: 1348 GADVDAADNRKITPLMSA 1365
Score = 52.4 bits (124), Expect = 8e-07
Identities = 66/254 (25%), Positives = 105/254 (41%), Gaps = 33/254 (12%)
Query: 51 VLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIA 110
++ LL A+ + E L++ A G A VLL HGA +N +AL +A
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 111 VLRNQPDMVELLVHHGAD-VNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADK 169
+ DMV L+ GAD ++ D +H + + + + + LLD GA VN
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTAL---MEACMDGHVEVARLLLDSGAQVNMPAD 436
Query: 170 HGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT-----------VFTCII 218
++ L LA+ G + E LL+E GA+++ +G T ++
Sbjct: 437 SFESPL--TLAACGG----HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490
Query: 219 FLLGETVGGDKEEAQ--MINRFC----FQVTRLLLAHGAD-PSECPAHESLTHICLKSFK 271
G + EE Q + C +V L+ GAD C T + S +
Sbjct: 491 LAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQE 545
Query: 272 LHFPLLRFLLESGA 285
H L+++LL SGA
Sbjct: 546 GHLELVKYLLASGA 559
Score = 47.8 bits (112), Expect = 2e-05
Identities = 57/233 (24%), Positives = 108/233 (46%), Gaps = 28/233 (12%)
Query: 73 LLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRR 132
L+ A G ++LL G ++ + T T L +A + ++V+LL+ GA+ R
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
Query: 133 DRIHESSPLDLASEEPERLPCLQRLLDLGADVNA--ADKHGKTALLHALASSDGVQIHNT 190
+ + + +PL LA+ + ++ LL+ GA++N+ K G + L+ LA+ +G +
Sbjct: 1152 N-VSDYTPLSLAA-SGGYVNIIKILLNAGAEINSRTGSKLGISPLM--LAAMNG----HV 1203
Query: 191 ENIRLLLEGGADVKA---TTKDGDTVFTC------IIFLLGETVGGDKEEA--------Q 233
++LLL+ G+D+ A T ++ C ++ LL + + A +
Sbjct: 1204 PAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLME 1263
Query: 234 MINRFCFQVTRLLLAHGADPSECPAHESL-THICLKSFKLHFPLLRFLLESGA 285
+ +V R+LL GAD + P S T + + + K H+ L+ GA
Sbjct: 1264 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
Score = 43.1 bits (100), Expect = 5e-04
Identities = 45/150 (30%), Positives = 70/150 (46%), Gaps = 16/150 (10%)
Query: 68 GVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGA 127
G S L++ ++ G LL GAN++ T TAL A D+ ++L+ GA
Sbjct: 534 GCSTPLMEASQEGHLELVKYLLASGANVH-ATTATGDTALTYACENGHTDVADVLLQAGA 592
Query: 128 DVNRRDRIHES----SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSD 183
D+ HES +PL + + L +Q L+ GA+VN A + ++ +LA +
Sbjct: 593 DLE-----HESEGGRTPL-MKAARAGHLCTVQFLISKGANVNRATANNDHTVV-SLACAG 645
Query: 184 GVQIHNTENIRLLLEGGADVKATTKDGDTV 213
G + + LLL GAD KDG T+
Sbjct: 646 G----HLAVVELLLAHGADPTHRLKDGSTM 671
Score = 41.2 bits (95), Expect = 0.002
Identities = 61/252 (24%), Positives = 101/252 (40%), Gaps = 37/252 (14%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
A + + + +LL+ + E + L G A VLL AN+
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGA 162
T L A D+V+LL+ H ADVN + ++ L A + ++ LL+ GA
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA-LTYAC-AGGFVDIVKVLLNEGA 329
Query: 163 DVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG 222
++ +++G T L+ A ++ + E R+LL+ GA + + +
Sbjct: 330 NIEDHNENGHTPLMEAASAG------HVEVARVLLDHGAGINTHSNE------------- 370
Query: 223 ETVGGDKEEAQMINRFCFQ----VTRLLLAHGADPSE--CPAHESLTHICLKSFKLHFPL 276
KE A + C++ + R LL GAD H +L C+ H +
Sbjct: 371 -----FKESA--LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG---HVEV 420
Query: 277 LRFLLESGAAYN 288
R LL+SGA N
Sbjct: 421 ARLLLDSGAQVN 432
Score = 38.1 bits (87), Expect = 0.015
Identities = 28/90 (31%), Positives = 37/90 (41%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
A E V LL+ A EG L+K A G L+ GAN+N
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRR 132
+T + +A +VELL+ HGAD R
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHR 664
Score = 36.2 bits (82), Expect = 0.057
Identities = 48/188 (25%), Positives = 81/188 (43%), Gaps = 25/188 (13%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADV 164
TAL +A ++V +L+ A + RD+ +PL LA+ + ++ LLD G D+
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDK-KGFTPLILAA-TAGHVGVVEILLDKGGDI 1114
Query: 165 NAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGET 224
A + K L +LA S G Q E + LLL GA+ K+ V L +
Sbjct: 1115 EAQSERTKDTPL-SLACSGGRQ----EVVDLLLARGAN-----KEHRNVSDYTPLSLAAS 1164
Query: 225 VGGDKEEAQMINRFCFQVTRLLLAHGAD-PSECPAHESLTHICLKSFKLHFPLLRFLLES 283
G + ++LL GA+ S + ++ + L + H P ++ LL+
Sbjct: 1165 GG------------YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDM 1212
Query: 284 GAAYNCSL 291
G+ N +
Sbjct: 1213 GSDINAQI 1220
Score = 34.3 bits (77), Expect = 0.22
Identities = 34/128 (26%), Positives = 55/128 (42%), Gaps = 8/128 (6%)
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESS 139
G VL+ A + D + T L +A +VE+L+ G D+ + + +
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGF-TPLILAATAGHVGVVEILLDKGGDIEAQSERTKDT 1124
Query: 140 PLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEG 199
PL LA R + LL GA+ + T L +LA+S G I++LL
Sbjct: 1125 PLSLAC-SGGRQEVVDLLLARGANKEHRNVSDYTPL--SLAASGGY----VNIIKILLNA 1177
Query: 200 GADVKATT 207
GA++ + T
Sbjct: 1178 GAEINSRT 1185
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 68.2 bits (165), Expect = 1e-11
Identities = 70/254 (27%), Positives = 117/254 (46%), Gaps = 28/254 (11%)
Query: 18 VDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMA 77
V +L G Q +S + P +A+ + + L+ER A+ + L++ A
Sbjct: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
Query: 78 ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHE 137
G +LL GAN+N + T TAL +A ++ + L+ GAD+ +
Sbjct: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI----ELGC 535
Query: 138 SSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLL 197
S+PL AS+E L ++ LL GA+V+A G TAL +A + +T+ +LL
Sbjct: 536 STPLMEASQE-GHLELVKYLLASGANVHATTATGDTALTYACENG------HTDVADVLL 588
Query: 198 EGGADVKATTKDGDTVF--------TCII-FLLGETVGGDKEEAQ----MINRFC----F 240
+ GAD++ ++ G T C + FL+ + ++ A +++ C
Sbjct: 589 QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648
Query: 241 QVTRLLLAHGADPS 254
V LLLAHGADP+
Sbjct: 649 AVVELLLAHGADPT 662
Score = 55.5 bits (132), Expect = 9e-08
Identities = 47/138 (34%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-P 100
+A + R V++ LL+RKA+ + L++ A G VLL GA++N P
Sbjct: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDL 160
+ TAL IA + ELL+H GA ++ R++ ++PL LAS +Q L+
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNK-KGNTPLWLAS-NGGHFDVVQLLVQA 1347
Query: 161 GADVNAADKHGKTALLHA 178
GADV+AAD T L+ A
Sbjct: 1348 GADVDAADNRKITPLMSA 1365
Score = 52.4 bits (124), Expect = 8e-07
Identities = 66/254 (25%), Positives = 105/254 (41%), Gaps = 33/254 (12%)
Query: 51 VLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIA 110
++ LL A+ + E L++ A G A VLL HGA +N +AL +A
Sbjct: 320 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 111 VLRNQPDMVELLVHHGAD-VNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADK 169
+ DMV L+ GAD ++ D +H + + + + + LLD GA VN
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTAL---MEACMDGHVEVARLLLDSGAQVNMPAD 436
Query: 170 HGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT-----------VFTCII 218
++ L LA+ G + E LL+E GA+++ +G T ++
Sbjct: 437 SFESPL--TLAACGG----HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALL 490
Query: 219 FLLGETVGGDKEEAQ--MINRFC----FQVTRLLLAHGAD-PSECPAHESLTHICLKSFK 271
G + EE Q + C +V L+ GAD C T + S +
Sbjct: 491 LAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQE 545
Query: 272 LHFPLLRFLLESGA 285
H L+++LL SGA
Sbjct: 546 GHLELVKYLLASGA 559
Score = 47.8 bits (112), Expect = 2e-05
Identities = 57/233 (24%), Positives = 108/233 (46%), Gaps = 28/233 (12%)
Query: 73 LLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRR 132
L+ A G ++LL G ++ + T T L +A + ++V+LL+ GA+ R
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
Query: 133 DRIHESSPLDLASEEPERLPCLQRLLDLGADVNA--ADKHGKTALLHALASSDGVQIHNT 190
+ + + +PL LA+ + ++ LL+ GA++N+ K G + L+ LA+ +G +
Sbjct: 1152 N-VSDYTPLSLAA-SGGYVNIIKILLNAGAEINSRTGSKLGISPLM--LAAMNG----HV 1203
Query: 191 ENIRLLLEGGADVKA---TTKDGDTVFTC------IIFLLGETVGGDKEEA--------Q 233
++LLL+ G+D+ A T ++ C ++ LL + + A +
Sbjct: 1204 PAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLME 1263
Query: 234 MINRFCFQVTRLLLAHGADPSECPAHESL-THICLKSFKLHFPLLRFLLESGA 285
+ +V R+LL GAD + P S T + + + K H+ L+ GA
Sbjct: 1264 AASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
Score = 43.1 bits (100), Expect = 5e-04
Identities = 45/150 (30%), Positives = 70/150 (46%), Gaps = 16/150 (10%)
Query: 68 GVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGA 127
G S L++ ++ G LL GAN++ T TAL A D+ ++L+ GA
Sbjct: 534 GCSTPLMEASQEGHLELVKYLLASGANVH-ATTATGDTALTYACENGHTDVADVLLQAGA 592
Query: 128 DVNRRDRIHES----SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSD 183
D+ HES +PL + + L +Q L+ GA+VN A + ++ +LA +
Sbjct: 593 DLE-----HESEGGRTPL-MKAARAGHLCTVQFLISKGANVNRATANNDHTVV-SLACAG 645
Query: 184 GVQIHNTENIRLLLEGGADVKATTKDGDTV 213
G + + LLL GAD KDG T+
Sbjct: 646 G----HLAVVELLLAHGADPTHRLKDGSTM 671
Score = 41.2 bits (95), Expect = 0.002
Identities = 61/252 (24%), Positives = 101/252 (40%), Gaps = 37/252 (14%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
A + + + +LL+ + E + L G A VLL AN+
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGA 162
T L A D+V+LL+ H ADVN + ++ L A + ++ LL+ GA
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA-LTYAC-AGGFVDIVKVLLNEGA 329
Query: 163 DVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLG 222
++ +++G T L+ A ++ + E R+LL+ GA + + +
Sbjct: 330 NIEDHNENGHTPLMEAASAG------HVEVARVLLDHGAGINTHSNE------------- 370
Query: 223 ETVGGDKEEAQMINRFCFQ----VTRLLLAHGADPSE--CPAHESLTHICLKSFKLHFPL 276
KE A + C++ + R LL GAD H +L C+ H +
Sbjct: 371 -----FKESA--LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG---HVEV 420
Query: 277 LRFLLESGAAYN 288
R LL+SGA N
Sbjct: 421 ARLLLDSGAQVN 432
Score = 38.1 bits (87), Expect = 0.015
Identities = 28/90 (31%), Positives = 37/90 (41%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
A E V LL+ A EG L+K A G L+ GAN+N
Sbjct: 575 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN 634
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRR 132
+T + +A +VELL+ HGAD R
Sbjct: 635 DHTVVSLACAGGHLAVVELLLAHGADPTHR 664
Score = 36.2 bits (82), Expect = 0.057
Identities = 48/188 (25%), Positives = 81/188 (43%), Gaps = 25/188 (13%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADV 164
TAL +A ++V +L+ A + RD+ +PL LA+ + ++ LLD G D+
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDK-KGFTPLILAA-TAGHVGVVEILLDKGGDI 1114
Query: 165 NAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGET 224
A + K L +LA S G Q E + LLL GA+ K+ V L +
Sbjct: 1115 EAQSERTKDTPL-SLACSGGRQ----EVVDLLLARGAN-----KEHRNVSDYTPLSLAAS 1164
Query: 225 VGGDKEEAQMINRFCFQVTRLLLAHGAD-PSECPAHESLTHICLKSFKLHFPLLRFLLES 283
G + ++LL GA+ S + ++ + L + H P ++ LL+
Sbjct: 1165 GG------------YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDM 1212
Query: 284 GAAYNCSL 291
G+ N +
Sbjct: 1213 GSDINAQI 1220
Score = 34.3 bits (77), Expect = 0.22
Identities = 34/128 (26%), Positives = 55/128 (42%), Gaps = 8/128 (6%)
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESS 139
G VL+ A + D + T L +A +VE+L+ G D+ + + +
Sbjct: 1066 GHEELVSVLIARDAKIEHRDKKGF-TPLILAATAGHVGVVEILLDKGGDIEAQSERTKDT 1124
Query: 140 PLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEG 199
PL LA R + LL GA+ + T L +LA+S G I++LL
Sbjct: 1125 PLSLAC-SGGRQEVVDLLLARGANKEHRNVSDYTPL--SLAASGGY----VNIIKILLNA 1177
Query: 200 GADVKATT 207
GA++ + T
Sbjct: 1178 GAEINSRT 1185
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 67.4 bits (163), Expect = 2e-11
Identities = 52/170 (30%), Positives = 88/170 (51%), Gaps = 9/170 (5%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
AS+E + ++ ELL+ + G AL+ G T ++LL HGAN + +
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGA 162
Y + A R D+V LL+ +GA VN D+ + ++PL A+ + L C++ LL +GA
Sbjct: 138 VYPIIWAAG-RGHADIVHLLLQNGAKVNCSDK-YGTTPLVWAARKGH-LECVKHLLAMGA 194
Query: 163 DVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
DV+ + TAL+ A+ T++++ +L+ +V T KDG+T
Sbjct: 195 DVDQEGANSMTALIVAVKGG------YTQSVKEILKRNPNVNLTDKDGNT 238
Score = 46.2 bits (108), Expect = 6e-05
Identities = 43/160 (26%), Positives = 76/160 (47%), Gaps = 23/160 (14%)
Query: 147 EPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVK-- 204
E E +P L+ LL+ DV+ ++ G+T L+ +A+ G N E ++ L++ GA+
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLM--IAAEQG----NLEIVKELIKNGANCNLE 67
Query: 205 ---------ATTKDG-----DTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHG 250
+ +K+G + + C + L +GG + V LLL+HG
Sbjct: 68 DLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHG 127
Query: 251 ADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCS 290
A+PS + S+ I + + H ++ LL++GA NCS
Sbjct: 128 ANPSVTGLY-SVYPIIWAAGRGHADIVHLLLQNGAKVNCS 166
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/176 (26%), Positives = 77/176 (43%), Gaps = 32/176 (18%)
Query: 66 QEGVSN--ALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLV 123
QEG ++ AL+ + G T++ +L+ N+N D TAL IA ++V+ L+
Sbjct: 198 QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDK-DGNTALMIASKEGHTEIVQDLL 256
Query: 124 HHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHA----- 178
G VN DR ++ + + + + ++ LL AD++ + KTAL A
Sbjct: 257 DAGTYVNIPDRSGDT--VLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
Query: 179 ---------------LASSDG-------VQIHNTENIRLLLEGGADVKATTKDGDT 212
+ + DG ++ N E + LLL+ GA V A K GDT
Sbjct: 315 ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDT 370
Score = 33.1 bits (74), Expect = 0.49
Identities = 33/134 (24%), Positives = 58/134 (43%), Gaps = 3/134 (2%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPV 101
+AS+E ++ +LL+ + L+ G LL+ A+++
Sbjct: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301
Query: 102 TYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLG 161
TAL+ AV + MV ++ D + E+ PL + + + + ++ LLD G
Sbjct: 302 NK-TALYWAVEKGNATMVRDILQCNPDTEICTKDGET-PL-IKATKMRNIEVVELLLDKG 358
Query: 162 ADVNAADKHGKTAL 175
A V+A DK G T L
Sbjct: 359 AKVSAVDKKGDTPL 372
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 66.6 bits (161), Expect = 4e-11
Identities = 56/187 (29%), Positives = 97/187 (51%), Gaps = 13/187 (6%)
Query: 30 PERQE---SLDRPSYV-ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAA 85
PE +E +D +++ A+ E ++ V+ + L + + AL + + G
Sbjct: 138 PEPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEIL 197
Query: 86 DVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLAS 145
+ LL +GA ++F+D + TA+H A ++V+LL HGAD N RD++ S+PL +A
Sbjct: 198 EKLLDNGATVDFQDRLDC-TAMHWACRGGHLEVVKLLQSHGADTNVRDKL-LSTPLHVAV 255
Query: 146 EEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKA 205
+ + ++ L LG ++NA D+ G TAL D V+++ + I+LLL GAD+
Sbjct: 256 RTGQ-VEIVEHFLSLGLEINARDREGDTAL------HDAVRLNRYKIIKLLLLHGADMMT 308
Query: 206 TTKDGDT 212
G T
Sbjct: 309 KNLAGKT 315
Score = 47.0 bits (110), Expect = 3e-05
Identities = 50/179 (27%), Positives = 80/179 (44%), Gaps = 26/179 (14%)
Query: 74 LKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRD 133
LK A G + + L G + + D TALH A L +++E L+ +GA V+ +D
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRR-TALHRASLEGHMEILEKLLDNGATVDFQD 211
Query: 134 RIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENI 193
R+ + + + A L ++ L GAD N DK T L H + V+I +
Sbjct: 212 RL-DCTAMHWACRGGH-LEVVKLLQSHGADTNVRDKLLSTPL-HVAVRTGQVEI-----V 263
Query: 194 RLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGAD 252
L G ++ A ++GDT +A +NR+ ++ +LLL HGAD
Sbjct: 264 EHFLSLGLEINARDREGDTAL---------------HDAVRLNRY--KIIKLLLLHGAD 305
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 66.2 bits (160), Expect = 5e-11
Identities = 67/267 (25%), Positives = 118/267 (44%), Gaps = 35/267 (13%)
Query: 26 GIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAA 85
G+ + R ++ P ++A+ E L+ L+E+ A + + ++ G
Sbjct: 837 GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCV 896
Query: 86 DVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLAS 145
+LL + +N++ + AL +A L D+VELL HGADVN +D + LA
Sbjct: 897 QILLENKSNID-QRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILAL 955
Query: 146 EEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKA 205
E +L + L+ GA+V A+D G+TAL + + E +++L+ ADV A
Sbjct: 956 E--NQLTMAEYFLENGANVEASDAEGRTALHVSCWQG------HMEMVQVLIAYHADVNA 1007
Query: 206 TTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQ----VTRLLLAHGADPSECPAHES 261
D E+ + +Q V +LL+ HGA + ++
Sbjct: 1008 ---------------------ADNEKRSALQSAAWQGHVKVVQLLIEHGA-VVDHTCNQG 1045
Query: 262 LTHICLKSFKLHFPLLRFLLESGAAYN 288
T +C+ + + H +++ LLE GA N
Sbjct: 1046 ATALCIAAQEGHIDVVQVLLEHGADPN 1072
Score = 60.1 bits (144), Expect = 4e-09
Identities = 66/222 (29%), Positives = 99/222 (44%), Gaps = 31/222 (13%)
Query: 88 LLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLAS-- 145
LL+HGA +N D TAL A ++VE L+ HGA+VN D + + L +A+
Sbjct: 663 LLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEVNHED-VDGRTALSVAALC 720
Query: 146 --EEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADV 203
+ L+D GA+V+ DK G T LL +A+ +G + + + LLLEGGADV
Sbjct: 721 VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLL--VAAYEG----HVDVVDLLLEGGADV 774
Query: 204 KATTKDGDT------------VFTCIIFLLGETVGGDKEEAQMINRFC-----FQVTRLL 246
T +G T V ++F G V E + + +V R L
Sbjct: 775 DHTDNNGRTPLLAAASMGHASVVNTLLF-WGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
Query: 247 LAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYN 288
L G D + T + + +F+ H + L+E GA N
Sbjct: 834 LDRGLDENH-RDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Score = 58.2 bits (139), Expect = 1e-08
Identities = 57/209 (27%), Positives = 95/209 (45%), Gaps = 22/209 (10%)
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIH 136
A G T+ + L+ GAN+N D +TAL A ++V L++ G V+ D
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQ-DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
Query: 137 ESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLL 196
++ A E + + LL GA+VN AD G+TAL+ A + + E + L
Sbjct: 645 RTALRAAAWGGHEDI--VLNLLQHGAEVNKADNEGRTALIAA------AYMGHREIVEHL 696
Query: 197 LEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSEC 256
L+ GA+V DG T + + V K A +++ LL+ GA+ C
Sbjct: 697 LDHGAEVNHEDVDGRTALS----VAALCVPASKGHASVVS--------LLIDRGAEVDHC 744
Query: 257 PAHESLTHICLKSFKLHFPLLRFLLESGA 285
+ +T + + +++ H ++ LLE GA
Sbjct: 745 D-KDGMTPLLVAAYEGHVDVVDLLLEGGA 772
Score = 50.1 bits (118), Expect = 4e-06
Identities = 57/201 (28%), Positives = 85/201 (42%), Gaps = 27/201 (13%)
Query: 88 LLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEE 147
LL +GA++N D T L A D+V LLV GAD+ D H +PL LA+ +
Sbjct: 531 LLDNGASVNQCDS-NGRTLLANAAYSGSLDVVNLLVSRGADLEIED-AHGHTPLTLAARQ 588
Query: 148 PERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATT 207
+ L+ GA++N D+ G TAL A +TE + LL G V
Sbjct: 589 -GHTKVVNCLIGCGANINHTDQDGWTALRSAAWGG------HTEVVSALLYAGVKVDCAD 641
Query: 208 KDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICL 267
D T L GG ++ + LL HGA+ ++ +E T +
Sbjct: 642 ADSRTA------LRAAAWGGHED-----------IVLNLLQHGAEVNKAD-NEGRTALIA 683
Query: 268 KSFKLHFPLLRFLLESGAAYN 288
++ H ++ LL+ GA N
Sbjct: 684 AAYMGHREIVEHLLDHGAEVN 704
Score = 49.3 bits (116), Expect = 7e-06
Identities = 68/297 (22%), Positives = 117/297 (39%), Gaps = 66/297 (22%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-- 99
V + + V++ L++R A + LL A G D+LL GA+++ D
Sbjct: 721 VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN 780
Query: 100 ------------------PVTYY------------TALHIAVLRNQPDMVELLVHHGADV 129
+ ++ T L IA + ++V L+ G D
Sbjct: 781 GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840
Query: 130 NRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHN 189
N RD +PL +A+ E RL C + L++ GA N D G+ + LAS +G +
Sbjct: 841 NHRDDA-GWTPLHMAAFEGHRLIC-EALIEQGARTNEIDNDGRIPFI--LASQEG----H 892
Query: 190 TENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAH 249
+ +++LLE +++ DG L + G ++ + LL +H
Sbjct: 893 YDCVQILLENKSNIDQRGYDGRNA------LRVAALEGHRD-----------IVELLFSH 935
Query: 250 GADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCS-------LHGASCWSG 299
GAD + C + + + + + + + LE+GA S LH SCW G
Sbjct: 936 GADVN-CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALH-VSCWQG 990
Score = 47.8 bits (112), Expect = 2e-05
Identities = 43/131 (32%), Positives = 64/131 (48%), Gaps = 9/131 (6%)
Query: 72 ALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNR 131
AL A G +L+ GA ++ D T L +A D+V+LL+ GADV+
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDK-DGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776
Query: 132 RDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTE 191
D + +PL LA+ + LL GA V++ D G+T L ++AS+ G N E
Sbjct: 777 TDN-NGRTPL-LAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL--SIASAQG----NVE 828
Query: 192 NIRLLLEGGAD 202
+R LL+ G D
Sbjct: 829 VVRTLLDRGLD 839
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/165 (28%), Positives = 84/165 (50%), Gaps = 10/165 (6%)
Query: 38 RPS-YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLN 96
RP+ Y+ + E+++ + LE A+ AL G VL+ + A++N
Sbjct: 947 RPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
Query: 97 FEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQR 156
D +AL A + +V+LL+ HGA V+ ++ L +A++E + +Q
Sbjct: 1007 AADNEKR-SALQSAAWQGHVKVVQLLIEHGAVVDHTCN-QGATALCIAAQEGH-IDVVQV 1063
Query: 157 LLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGA 201
LL+ GAD N AD+ G+TA+ +A+ +G +++ I+LL + GA
Sbjct: 1064 LLEHGADPNHADQFGRTAM--RVAAKNG----HSQIIKLLEKYGA 1102
Score = 43.5 bits (101), Expect = 4e-04
Identities = 31/105 (29%), Positives = 51/105 (48%), Gaps = 10/105 (9%)
Query: 111 VLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKH 170
++ + ++++LLV GA VN D + + ER ++ LLD GA VN D +
Sbjct: 489 LIPKEQEVLQLLVKAGAHVNSED----DRTSCIVRQALEREDSIRTLLDNGASVNQCDSN 544
Query: 171 GKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFT 215
G+T L +A S + + + LL+ GAD++ G T T
Sbjct: 545 GRTLLANAAYSG------SLDVVNLLVSRGADLEIEDAHGHTPLT 583
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 65.9 bits (159), Expect = 7e-11
Identities = 44/132 (33%), Positives = 74/132 (56%), Gaps = 9/132 (6%)
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIH 136
A LG ++L+ GA +N +D + + T LH AV + V++L+ H ADVN RD+ +
Sbjct: 24 AFLGDAEIIELLILSGARVNAKDNM-WLTPLHRAVASRSEEAVQVLIKHSADVNARDK-N 81
Query: 137 ESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLL 196
+PL +A+ + + C + ++ L + VN +D+ G+TAL HA + + E + LL
Sbjct: 82 WQTPLHVAAAN-KAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNG------HVEMVNLL 134
Query: 197 LEGGADVKATTK 208
L GA++ A K
Sbjct: 135 LAKGANINAFDK 146
Score = 61.6 bits (148), Expect = 1e-09
Identities = 60/201 (29%), Positives = 90/201 (44%), Gaps = 30/201 (14%)
Query: 88 LLRHGANLNFE-DPVTYY--TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA 144
+++H NL E D + Y TALHIA Q +V L+ +GA+VN+ + + +PL A
Sbjct: 196 VVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNN-NGFTPLHFA 254
Query: 145 SEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNT-ENIRLLLEGGADV 203
+ CL+ L++ GADVN K GK+ LH A +H + L++ G ++
Sbjct: 255 AASTHGALCLELLVNNGADVNIQSKDGKSP-LHMTA------VHGRFTRSQTLIQNGGEI 307
Query: 204 KATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLT 263
KDG+T V +IN L GAD ++C H S+
Sbjct: 308 DCVDKDGNTPL---------HVAARYGHELLIN--------TLRTSGADTAKCGIH-SMF 349
Query: 264 HICLKSFKLHFPLLRFLLESG 284
+ L + H R LL SG
Sbjct: 350 PLHLAALNAHSDCCRKLLSSG 370
Score = 46.2 bits (108), Expect = 6e-05
Identities = 52/192 (27%), Positives = 82/192 (42%), Gaps = 22/192 (11%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADV 164
T LH A + ++LL GAD +++D+ + PL A+ C++ L+ GA+V
Sbjct: 382 TCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRT-PLHYAAANCH-FHCIETLVTTGANV 439
Query: 165 NAADKHGKTALLHALASS---DGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLL 221
N D G+TAL +A AS + + N + LE ++K C+ FLL
Sbjct: 440 NETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKE-----KEATLCLEFLL 494
Query: 222 GETVG---GDKEEAQMI-------NRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFK 271
DKE I +R C ++ G + S+ A +S H L ++
Sbjct: 495 QNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLH--LAAYN 552
Query: 272 LHFPLLRFLLES 283
H L LL+S
Sbjct: 553 GHHQALEVLLQS 564
Score = 45.4 bits (106), Expect = 9e-05
Identities = 55/226 (24%), Positives = 100/226 (44%), Gaps = 27/226 (11%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLD--LASEEPERLPCLQRLLDLGA 162
T LH+A +++ELL+ GA VN +D + +PL +AS E +Q L+ A
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVASRSEE---AVQVLIKHSA 73
Query: 163 DVNAADKHGKTALLHALASSDGVQ-----IHNTENIRLLLEGG-ADVKATTKDGDTVFTC 216
DVNA DK+ +T LH A++ V+ I ++ + GG + +G
Sbjct: 74 DVNARDKNWQTP-LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132
Query: 217 IIFLLGETVGG-DKEEAQMINRFCF----QVTRLLLAHGADPSECPAHESLTHICLKSFK 271
++ G + DK++ + ++ + V LL+ HGA+ + C + T + +
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT-CKDKKGYTPLHAAASN 191
Query: 272 LHFPLLRFLLESGAAY-------NCSLHGASCWSGFHIIFERLCSH 310
+++ LL G N +LH +C++G + L +
Sbjct: 192 GQINVVKHLLNLGVEIDEINVYGNTALH-IACYNGQDAVVNELIDY 236
Score = 37.7 bits (86), Expect = 0.020
Identities = 34/110 (30%), Positives = 50/110 (45%), Gaps = 11/110 (10%)
Query: 104 YTALHIAVLRNQPDMVELLVH--HGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLG 161
+T LH A++ + + LL+ + V+ RD +PL A+ + + CLQ LL
Sbjct: 780 FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDD-KGRTPLRAAAFA-DHVECLQLLLRHS 837
Query: 162 ADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGD 211
A VNA D GKTAL+ A + + +L A T KD D
Sbjct: 838 APVNAVDNSGKTALMMAAENGQAGAVD-------ILVNSAQADLTVKDKD 880
Score = 36.2 bits (82), Expect = 0.057
Identities = 44/176 (25%), Positives = 70/176 (39%), Gaps = 9/176 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A+ L LL+ E AL A G T + L+ GA++ +
Sbjct: 545 PLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK 604
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRD--RIHESSPLDLASEEPERLPCLQR 156
D VT T LH +V+ + LL+ + D +PL LA + +
Sbjct: 605 DNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAY-GHIDAVSL 663
Query: 157 LLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
LL+ A+V+ D G TAL G+ + E +++LLE + G T
Sbjct: 664 LLEKEANVDTVDILGCTAL------HRGIMTGHEECVQMLLEQEVSILCKDSRGRT 713
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 65.9 bits (159), Expect = 7e-11
Identities = 68/251 (27%), Positives = 107/251 (42%), Gaps = 42/251 (16%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P + A+ +R+ V+ LL A +G L G A++L+RHGA++N
Sbjct: 687 PLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVA 746
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASE------------ 146
D + +T LH A + + ++ +LL+ HGAD +++R ++PLDL E
Sbjct: 747 D-LWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNR-DGNTPLDLVKEGDTDIQDLLRGD 804
Query: 147 ----EPERLPCLQRLLDL--GADVNAADKHGKTAL-LHALASSDGVQIHNTENIRLLLEG 199
+ + CL R+ L ++N D G+ + LH A +N E LLE
Sbjct: 805 AALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAG-----YNNLEVAEYLLEH 859
Query: 200 GADVKATTKD-----------GDTVFTCIIFLLGETVGGDKEEA-----QMINRFCFQVT 243
GADV A K G ++ V + A + + Q+
Sbjct: 860 GADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLC 919
Query: 244 RLLLAHGADPS 254
LLLAHGADP+
Sbjct: 920 ALLLAHGADPT 930
Score = 54.7 bits (130), Expect = 2e-07
Identities = 75/261 (28%), Positives = 107/261 (40%), Gaps = 52/261 (19%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P + A+ R V+ LL+ A+ +G L G +LL GA+ N
Sbjct: 219 PLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR 278
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA-------------- 144
D Y T LH A ++ + D+ +L+ HGAD N R+ +S+ LDLA
Sbjct: 279 DNWNY-TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSA-LDLADPSAKAVLTGEYKK 336
Query: 145 --------SEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLL 196
S E+L L L L + +A+D K+ LH A + V+I ++LL
Sbjct: 337 DELLEAARSGNEEKLMAL--LTPLNVNCHASDGR-KSTPLHLAAGYNRVRI-----VQLL 388
Query: 197 LEGGADVKATTKD-----------GDTVFTCIIFLLGETVGG-------DKEEAQMINRF 238
L+ GADV A K G T ++ G V EA NR
Sbjct: 389 LQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNR- 447
Query: 239 CFQVTRLLLAHGADPSECPAH 259
+V LLL+HGADP+ H
Sbjct: 448 -VEVCSLLLSHGADPTLVNCH 467
Score = 48.1 bits (113), Expect = 1e-05
Identities = 73/275 (26%), Positives = 113/275 (41%), Gaps = 49/275 (17%)
Query: 20 AILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAEL 79
A+L L + P ++A+ +R+ ++ LL+ A +G L
Sbjct: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESS 139
G ++LL+HGA +N D + +T LH A +N+ ++ LL+ HGAD + H S
Sbjct: 413 GHYEVTELLLKHGACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN-CHGKS 470
Query: 140 PLDLA--SEEPERLPCL---QRLLDLGADVNAA---------------DKHGKTALLHAL 179
+D+A E ERL LL + + A + +TAL A+
Sbjct: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
Query: 180 ASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGD------KEEAQ 233
AS + TE LLL GA+V KD F + + E D K A+
Sbjct: 531 ASLHPKRKQVTE---LLLRKGANVNEKNKD----FMTPLHVAAERAHNDVMEVLHKHGAK 583
Query: 234 M----------INRFC----FQVTRLLLAHGADPS 254
M ++R Q RLLL++G+DPS
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPS 618
Score = 46.6 bits (109), Expect = 4e-05
Identities = 48/152 (31%), Positives = 66/152 (43%), Gaps = 10/152 (6%)
Query: 62 SPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-PVTYYTALHIAVLRNQPDMVE 120
+P V LL+ ++ G L N+N D + T LH A N+ +VE
Sbjct: 643 TPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVE 701
Query: 121 LLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALA 180
L+HHGADV+ +D+ PL A + L+ GA VN AD T L A A
Sbjct: 702 YLLHHGADVHAKDK-GGLVPLHNACSY-GHYEVAELLVRHGASVNVADLWKFTPLHEAAA 759
Query: 181 SSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
E +LLL+ GAD +DG+T
Sbjct: 760 KG------KYEICKLLLKHGADPTKKNRDGNT 785
Score = 42.7 bits (99), Expect = 6e-04
Identities = 31/92 (33%), Positives = 49/92 (53%), Gaps = 3/92 (3%)
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLD 142
+ ++LLR GAN+N E + T LH+A R D++E+L HGA +N D + +++ L
Sbjct: 539 QVTELLLRKGANVN-EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA-LH 596
Query: 143 LASEEPERLPCLQRLLDLGADVNAADKHGKTA 174
A+ C + LL G+D + G TA
Sbjct: 597 RAALAGHLQTC-RLLLSYGSDPSIISLQGFTA 627
Score = 40.8 bits (94), Expect = 0.002
Identities = 35/116 (30%), Positives = 52/116 (44%), Gaps = 24/116 (20%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDR-----IHESSP---LDLASEEPERLPCLQR 156
T LH+A N ++ E L+ HGADVN +D+ +H ++ +D+A+
Sbjct: 839 TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAA----------L 888
Query: 157 LLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
L+ VNA DK T L + Q T+ LLL GAD ++G T
Sbjct: 889 LIKYNTCVNATDKWAFTPL------HEAAQKGRTQLCALLLAHGADPTMKNQEGQT 938
Score = 38.5 bits (88), Expect = 0.012
Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 2/112 (1%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A+ + + V LLE A +G L A G A +L+++ +N
Sbjct: 840 PLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNAT 899
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPER 150
D + T LH A + + + LL+ HGAD +++ +PLDLA+ + R
Sbjct: 900 DKWAF-TPLHEAAQKGRTQLCALLLAHGADPTMKNQ-EGQTPLDLATADDIR 949
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 65.5 bits (158), Expect = 9e-11
Identities = 69/254 (27%), Positives = 116/254 (45%), Gaps = 28/254 (11%)
Query: 18 VDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMA 77
V +L G Q +S + P +A+ + + L+ER A + L++ A
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 78 ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHE 137
G +LL GAN+N + T TAL +A ++ + L+ GAD+ +
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI----ELGC 564
Query: 138 SSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLL 197
S+PL A++E L ++ LL GA+V+A G TAL +A + +T+ +LL
Sbjct: 565 STPLMEAAQE-GHLELVKYLLAAGANVHATTATGDTALTYACENG------HTDVADVLL 617
Query: 198 EGGADVKATTKDGDTVF--------TCII-FLLGETVGGDKEEAQ----MINRFC----F 240
+ GAD++ ++ G T C + FL+ + ++ A +++ C
Sbjct: 618 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 241 QVTRLLLAHGADPS 254
V LLLAHGADP+
Sbjct: 678 AVVELLLAHGADPT 691
Score = 55.1 bits (131), Expect = 1e-07
Identities = 68/277 (24%), Positives = 126/277 (45%), Gaps = 28/277 (10%)
Query: 29 DPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVL 88
D + + + D +A ++ LLER A + L+ A G ++L
Sbjct: 1076 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 1135
Query: 89 LRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEP 148
L +GA++ + T T L +A + ++VELL+ GA+ R+ + + +PL LA+
Sbjct: 1136 LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN-VSDYTPLSLAA-SG 1193
Query: 149 ERLPCLQRLLDLGADVNA--ADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKA- 205
+ ++ LL+ GA++N+ K G + L+ LA+ +G +T ++LLL+ G+D+ A
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLM--LAAMNG----HTAAVKLLLDMGSDINAQ 1247
Query: 206 --TTKDGDTVFTC------IIFLLGETVGGDKEEA--------QMINRFCFQVTRLLLAH 249
T ++ C ++ LL + + A + + +V R+LL
Sbjct: 1248 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307
Query: 250 GADPSECPAHESL-THICLKSFKLHFPLLRFLLESGA 285
GAD + P S T + + + K H+ L+ GA
Sbjct: 1308 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1344
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/138 (33%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-P 100
+A + R V++ LL+RKA+ + L++ A G VLL GA++N P
Sbjct: 1258 LACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1317
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDL 160
+ TAL IA + ELL+ GA ++ R++ ++PL LA+ L +Q L+
Sbjct: 1318 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK-KGNTPLWLAANGGH-LDVVQLLVQA 1375
Query: 161 GADVNAADKHGKTALLHA 178
GADV+AAD T L+ A
Sbjct: 1376 GADVDAADNRKITPLMAA 1393
Score = 45.8 bits (107), Expect = 7e-05
Identities = 64/253 (25%), Positives = 103/253 (40%), Gaps = 31/253 (12%)
Query: 51 VLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIA 110
V+ LLE A + E L++ G A +LL +GA +N +AL +A
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLA 408
Query: 111 VLRNQPDMVELLVHHGAD-VNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADK 169
+ +MV L+ GAD ++ D +H + + + + + LLD GA VN
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDEMHTAL---MEACMDGHVEVARLLLDSGAQVNMPAD 465
Query: 170 HGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVF---------TCIIFL 220
++ L LA+ G + E LL+E GA ++ +G T + L
Sbjct: 466 SFESPL--TLAACGG----HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519
Query: 221 LGE--TVGGDKEEAQ--MINRFC----FQVTRLLLAHGADPSECPAHESLTHICLKSFKL 272
LG+ + EE Q + C +V L+ GAD E L +
Sbjct: 520 LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD-IELGCSTPLMEAAQEG--- 575
Query: 273 HFPLLRFLLESGA 285
H L+++LL +GA
Sbjct: 576 HLELVKYLLAAGA 588
Score = 44.3 bits (103), Expect = 2e-04
Identities = 72/293 (24%), Positives = 114/293 (38%), Gaps = 43/293 (14%)
Query: 55 LLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRN 114
L+E ++ + +EG S L G A VLL AN+ T L A
Sbjct: 254 LIEGRSVNEHTEEGES-LLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
Query: 115 QPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTA 174
+V+LL+ H ADVN + ++ L A + ++ LL+ GA + +++G T
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTA-LTYAC-AGGYVDVVKVLLESGASIEDHNENGHTP 370
Query: 175 LLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQM 234
L+ A ++ + E RLLLE GA + + + + G
Sbjct: 371 LMEAGSAG------HVEVARLLLENGAGINTHSNEFKESALTLACYKGH----------- 413
Query: 235 INRFCFQVTRLLLAHGADPSE--CPAHESLTHICLKSFKLHFPLLRFLLESGA------- 285
++ R LL GAD H +L C+ H + R LL+SGA
Sbjct: 414 -----LEMVRFLLEAGADQEHKTDEMHTALMEACMDG---HVEVARLLLDSGAQVNMPAD 465
Query: 286 AYNCSLHGASCWSGFHIIFERLCSHPGCT----EDESHADLLRKAETVLDLMV 334
++ L A+C G H+ L G + DE + L+ A + MV
Sbjct: 466 SFESPLTLAAC--GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516
Score = 42.4 bits (98), Expect = 8e-04
Identities = 45/150 (30%), Positives = 69/150 (46%), Gaps = 16/150 (10%)
Query: 68 GVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGA 127
G S L++ A+ G LL GAN++ T TAL A D+ ++L+ GA
Sbjct: 563 GCSTPLMEAAQEGHLELVKYLLAAGANVH-ATTATGDTALTYACENGHTDVADVLLQAGA 621
Query: 128 DVNRRDRIHES----SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSD 183
D+ HES +PL + + + +Q L+ GA+VN + +L +LA +
Sbjct: 622 DLE-----HESEGGRTPL-MKAARAGHVCTVQFLISKGANVNRTTANNDHTVL-SLACAG 674
Query: 184 GVQIHNTENIRLLLEGGADVKATTKDGDTV 213
G + + LLL GAD KDG T+
Sbjct: 675 G----HLAVVELLLAHGADPTHRLKDGSTM 700
Score = 39.7 bits (91), Expect = 0.005
Identities = 29/90 (32%), Positives = 37/90 (41%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
A E V LL+ A EG L+K A G L+ GAN+N
Sbjct: 604 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN 663
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRR 132
+T L +A +VELL+ HGAD R
Sbjct: 664 DHTVLSLACAGGHLAVVELLLAHGADPTHR 693
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 65.5 bits (158), Expect = 9e-11
Identities = 69/254 (27%), Positives = 116/254 (45%), Gaps = 28/254 (11%)
Query: 18 VDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMA 77
V +L G Q +S + P +A+ + + L+ER A + L++ A
Sbjct: 449 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAA 508
Query: 78 ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHE 137
G +LL GAN+N + T TAL +A ++ + L+ GAD+ +
Sbjct: 509 REGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI----ELGC 564
Query: 138 SSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLL 197
S+PL A++E L ++ LL GA+V+A G TAL +A + +T+ +LL
Sbjct: 565 STPLMEAAQE-GHLELVKYLLAAGANVHATTATGDTALTYACENG------HTDVADVLL 617
Query: 198 EGGADVKATTKDGDTVF--------TCII-FLLGETVGGDKEEAQ----MINRFC----F 240
+ GAD++ ++ G T C + FL+ + ++ A +++ C
Sbjct: 618 QAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 241 QVTRLLLAHGADPS 254
V LLLAHGADP+
Sbjct: 678 AVVELLLAHGADPT 691
Score = 55.1 bits (131), Expect = 1e-07
Identities = 68/277 (24%), Positives = 126/277 (45%), Gaps = 28/277 (10%)
Query: 29 DPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVL 88
D + + + D +A ++ LLER A + L+ A G ++L
Sbjct: 825 DAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEIL 884
Query: 89 LRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEP 148
L +GA++ + T T L +A + ++VELL+ GA+ R+ + + +PL LA+
Sbjct: 885 LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRN-VSDYTPLSLAA-SG 942
Query: 149 ERLPCLQRLLDLGADVNA--ADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKA- 205
+ ++ LL+ GA++N+ K G + L+ LA+ +G +T ++LLL+ G+D+ A
Sbjct: 943 GYVNIIKILLNAGAEINSRTGSKLGISPLM--LAAMNG----HTAAVKLLLDMGSDINAQ 996
Query: 206 --TTKDGDTVFTC------IIFLLGETVGGDKEEA--------QMINRFCFQVTRLLLAH 249
T ++ C ++ LL + + A + + +V R+LL
Sbjct: 997 IETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1056
Query: 250 GADPSECPAHESL-THICLKSFKLHFPLLRFLLESGA 285
GAD + P S T + + + K H+ L+ GA
Sbjct: 1057 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGA 1093
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/138 (33%), Positives = 71/138 (51%), Gaps = 3/138 (2%)
Query: 42 VASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFED-P 100
+A + R V++ LL+RKA+ + L++ A G VLL GA++N P
Sbjct: 1007 LACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1066
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDL 160
+ TAL IA + ELL+ GA ++ R++ ++PL LA+ L +Q L+
Sbjct: 1067 SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNK-KGNTPLWLAANGGH-LDVVQLLVQA 1124
Query: 161 GADVNAADKHGKTALLHA 178
GADV+AAD T L+ A
Sbjct: 1125 GADVDAADNRKITPLMAA 1142
Score = 45.8 bits (107), Expect = 7e-05
Identities = 64/253 (25%), Positives = 103/253 (40%), Gaps = 31/253 (12%)
Query: 51 VLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIA 110
V+ LLE A + E L++ G A +LL +GA +N +AL +A
Sbjct: 349 VVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLA 408
Query: 111 VLRNQPDMVELLVHHGAD-VNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADK 169
+ +MV L+ GAD ++ D +H + + + + + LLD GA VN
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDEMHTAL---MEACMDGHVEVARLLLDSGAQVNMPAD 465
Query: 170 HGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVF---------TCIIFL 220
++ L LA+ G + E LL+E GA ++ +G T + L
Sbjct: 466 SFESPL--TLAACGG----HVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519
Query: 221 LGE--TVGGDKEEAQ--MINRFC----FQVTRLLLAHGADPSECPAHESLTHICLKSFKL 272
LG+ + EE Q + C +V L+ GAD E L +
Sbjct: 520 LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGAD-IELGCSTPLMEAAQEG--- 575
Query: 273 HFPLLRFLLESGA 285
H L+++LL +GA
Sbjct: 576 HLELVKYLLAAGA 588
Score = 44.3 bits (103), Expect = 2e-04
Identities = 72/293 (24%), Positives = 114/293 (38%), Gaps = 43/293 (14%)
Query: 55 LLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRN 114
L+E ++ + +EG S L G A VLL AN+ T L A
Sbjct: 254 LIEGRSVNEHTEEGES-LLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGG 312
Query: 115 QPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTA 174
+V+LL+ H ADVN + ++ L A + ++ LL+ GA + +++G T
Sbjct: 313 HVKIVKLLLAHKADVNAQSSTGNTA-LTYAC-AGGYVDVVKVLLESGASIEDHNENGHTP 370
Query: 175 LLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQM 234
L+ A ++ + E RLLLE GA + + + + G
Sbjct: 371 LMEAGSAG------HVEVARLLLENGAGINTHSNEFKESALTLACYKGH----------- 413
Query: 235 INRFCFQVTRLLLAHGADPSE--CPAHESLTHICLKSFKLHFPLLRFLLESGA------- 285
++ R LL GAD H +L C+ H + R LL+SGA
Sbjct: 414 -----LEMVRFLLEAGADQEHKTDEMHTALMEACMDG---HVEVARLLLDSGAQVNMPAD 465
Query: 286 AYNCSLHGASCWSGFHIIFERLCSHPGCT----EDESHADLLRKAETVLDLMV 334
++ L A+C G H+ L G + DE + L+ A + MV
Sbjct: 466 SFESPLTLAAC--GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMV 516
Score = 42.4 bits (98), Expect = 8e-04
Identities = 45/150 (30%), Positives = 69/150 (46%), Gaps = 16/150 (10%)
Query: 68 GVSNALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGA 127
G S L++ A+ G LL GAN++ T TAL A D+ ++L+ GA
Sbjct: 563 GCSTPLMEAAQEGHLELVKYLLAAGANVH-ATTATGDTALTYACENGHTDVADVLLQAGA 621
Query: 128 DVNRRDRIHES----SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSD 183
D+ HES +PL + + + +Q L+ GA+VN + +L +LA +
Sbjct: 622 DLE-----HESEGGRTPL-MKAARAGHVCTVQFLISKGANVNRTTANNDHTVL-SLACAG 674
Query: 184 GVQIHNTENIRLLLEGGADVKATTKDGDTV 213
G + + LLL GAD KDG T+
Sbjct: 675 G----HLAVVELLLAHGADPTHRLKDGSTM 700
Score = 39.7 bits (91), Expect = 0.005
Identities = 29/90 (32%), Positives = 37/90 (41%)
Query: 43 ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT 102
A E V LL+ A EG L+K A G L+ GAN+N
Sbjct: 604 ACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN 663
Query: 103 YYTALHIAVLRNQPDMVELLVHHGADVNRR 132
+T L +A +VELL+ HGAD R
Sbjct: 664 DHTVLSLACAGGHLAVVELLLAHGADPTHR 693
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 63.5 bits (153), Expect = 3e-10
Identities = 99/355 (27%), Positives = 147/355 (41%), Gaps = 39/355 (10%)
Query: 80 GLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESS 139
G T A L+R GA L+ V ALH A R Q D V LL+ GA N ++
Sbjct: 122 GYTDCARHLIRQGAELDAR--VGGRAALHEACARAQFDCVRLLLTFGAKANVLTE-EGTT 178
Query: 140 PLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEG 199
PL L + PE L C + LL+ GA VN A + LH +A++ G++ H + L LE
Sbjct: 179 PLHLCTI-PESLQCAKLLLEAGATVNLAAGESQETPLH-VAAARGLEQH----VALYLEH 232
Query: 200 GADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGAD------P 253
GADV T G+T T E R RLL A GAD
Sbjct: 233 GADVGLRTSQGETAL--------NTACAGAEGPGSCRRHQAAARRLLEA-GADARAAGRK 283
Query: 254 SECPAHESLTHIC--LKSFKLHFPLLRFLLESGAAY---NCSLHGASCWSGF--HIIFER 306
P H + + C L L + R + +GA + +C+L + ++F
Sbjct: 284 RHTPLHNACANGCGGLAELLLRYG-ARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAA 342
Query: 307 LCSH---PGCTEDESHADLLRKAETVLDLMVTNSQKLQLPENFDIHPVGSLAEKIQALHF 363
L + P E H +A L++++ + E + + L ++ +A +
Sbjct: 343 LLDYGAQPVRPEMLKHCANFPRA---LEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYS 399
Query: 364 SLRQLESYPPPLKHLCRVAIRLYLQPWPVDVKVKALPLPDRLKWYLLSEHSGSVE 418
S + + P L+HL R+A+R L LPLP L+ YLL G ++
Sbjct: 400 SALCMVNQPRQLQHLARLAVRARLGS-RCRQGATRLPLPPLLRDYLLLRVEGCIQ 453
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 63.2 bits (152), Expect = 4e-10
Identities = 54/196 (27%), Positives = 98/196 (50%), Gaps = 13/196 (6%)
Query: 27 IQDPERQ---ESLDRPSYV-ASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLT 82
+++PE + E +D P+++ A+ E+++ V+ + L K + E AL + G
Sbjct: 107 VKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHL 166
Query: 83 RAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLD 142
+ L+ GA + F D + TA+H A D+++LL++ GA ++ RD++ S+ L
Sbjct: 167 AIVEKLMEAGAQIEFRDMLES-TAIHWASRGGNLDVLKLLLNKGAKISARDKL-LSTALH 224
Query: 143 LASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGAD 202
+A C + L+ AD+NA D+ G T L D V+++ + IRLL+ GAD
Sbjct: 225 VA-VRTGHYECAEHLIACEADLNAKDREGDTPL------HDAVRLNRYKMIRLLIMYGAD 277
Query: 203 VKATTKDGDTVFTCII 218
+ G T ++
Sbjct: 278 LNIKNCAGKTPMDLVL 293
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 62.4 bits (150), Expect = 7e-10
Identities = 45/133 (33%), Positives = 69/133 (51%), Gaps = 9/133 (6%)
Query: 71 NALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
NAL A+ G LL++ D + TALH A + + P ++LL HGA VN
Sbjct: 90 NALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTALHDAAMADCPSSIQLLCDHGASVN 148
Query: 131 RRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNT 190
+D + +PL LA++ C Q L+D GADVN+ DK +TAL+ G +
Sbjct: 149 AKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNSRDKQNRTALML------GCEYGCR 200
Query: 191 ENIRLLLEGGADV 203
+ + +L++ GAD+
Sbjct: 201 DAVEVLIKNGADI 213
Score = 29.3 bits (64), Expect = 7.0
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 73 LLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRR 132
L+ ++ +L+ GA++N D TAL + D VE+L+ +GAD++
Sbjct: 158 LVLATQMSRPTICQLLIDRGADVNSRDKQNR-TALMLGCEYGCRDAVEVLIKNGADISLL 216
Query: 133 DRI-HESS 139
D + H+SS
Sbjct: 217 DALGHDSS 224
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 62.4 bits (150), Expect = 7e-10
Identities = 45/133 (33%), Positives = 69/133 (51%), Gaps = 9/133 (6%)
Query: 71 NALLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVN 130
NAL A+ G LL++ D + TALH A + + P ++LL HGA VN
Sbjct: 103 NALHLAAKYGHALCLQKLLQYNCPTEHAD-LQGRTALHDAAMADCPSSIQLLCDHGASVN 161
Query: 131 RRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNT 190
+D + +PL LA++ C Q L+D GADVN+ DK +TAL+ G +
Sbjct: 162 AKD-VDGRTPLVLATQMSRPTIC-QLLIDRGADVNSRDKQNRTALML------GCEYGCR 213
Query: 191 ENIRLLLEGGADV 203
+ + +L++ GAD+
Sbjct: 214 DAVEVLIKNGADI 226
Score = 29.3 bits (64), Expect = 7.0
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 2/68 (2%)
Query: 73 LLKMAELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRR 132
L+ ++ +L+ GA++N D TAL + D VE+L+ +GAD++
Sbjct: 171 LVLATQMSRPTICQLLIDRGADVNSRDKQNR-TALMLGCEYGCRDAVEVLIKNGADISLL 229
Query: 133 DRI-HESS 139
D + H+SS
Sbjct: 230 DALGHDSS 237
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 62.4 bits (150), Expect = 7e-10
Identities = 66/222 (29%), Positives = 99/222 (44%), Gaps = 26/222 (11%)
Query: 85 ADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA 144
A +LL GA++NF P T LHIA R MV LL+ GA + + + E +PL A
Sbjct: 255 AQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHCA 312
Query: 145 SEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVK 204
+ + + LLD GA + A K+G + + H A D + + +RLLL+ A++
Sbjct: 313 ARNGH-VRISEILLDHGAPIQAKTKNGLSPI-HMAAQGD-----HLDCVRLLLQYDAEID 365
Query: 205 ATTKDGDTVFTCIIFLLGETVG------GDKEEAQMINRFC----------FQVTRLLLA 248
T D T V G K ++ +N F +V LLL
Sbjct: 366 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425
Query: 249 HGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCS 290
GA + LT + + SF H P+++ LL+ GA+ N S
Sbjct: 426 TGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466
Score = 53.5 bits (127), Expect = 3e-07
Identities = 65/216 (30%), Positives = 95/216 (43%), Gaps = 33/216 (15%)
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIH 136
A G R A VLL GA N + +T LHIA +N ++ELL+ GA + D +
Sbjct: 379 AHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVT 434
Query: 137 ES--SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIR 194
ES +PL +AS LP ++ LL GA N ++ +T L A + +TE +
Sbjct: 435 ESGLTPLHVAS-FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG------HTEVAK 487
Query: 195 LLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPS 254
LL+ A V A KD T C +G T + +LLL + A+P+
Sbjct: 488 YLLQNKAKVNAKAKDDQTPLHCAA-RIGHT----------------NMVKLLLENNANPN 530
Query: 255 -ECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNC 289
A + HI + + H + LLE A+ C
Sbjct: 531 LATTAGHTPLHIAAR--EGHVETVLALLEKEASQAC 564
Score = 51.6 bits (122), Expect = 1e-06
Identities = 64/247 (25%), Positives = 102/247 (41%), Gaps = 31/247 (12%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P Y+A++E+ + V+ LLE A+ E L + G L+ +G
Sbjct: 147 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
P ALHIA + +L+ + + + + +PL +A+ E L Q LL
Sbjct: 207 LP-----ALHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHY-ENLNVAQLLL 259
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ GA VN ++G T L +AS G N +RLLL+ GA ++ TKD T C
Sbjct: 260 NRGASVNFTPQNGITPL--HIASRRG----NVIMVRLLLDRGAQIETKTKDELTPLHC-- 311
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
+++ +LL HGA P + L+ I + + H +R
Sbjct: 312 ---------------AARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVR 355
Query: 279 FLLESGA 285
LL+ A
Sbjct: 356 LLLQYDA 362
Score = 50.1 bits (118), Expect = 4e-06
Identities = 39/137 (28%), Positives = 67/137 (48%), Gaps = 3/137 (2%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++E ++ LL ++A+ + L +A+ G ADVL++HG ++
Sbjct: 671 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 730
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ YT LH+A +V+ L+ H ADVN + ++ SPL A+++ + LL
Sbjct: 731 TRMG-YTPLHVASHYGNIKLVKFLLQHQADVNAKTKL-GYSPLHQAAQQ-GHTDIVTLLL 787
Query: 159 DLGADVNAADKHGKTAL 175
GA N G T L
Sbjct: 788 KNGASPNEVSSDGTTPL 804
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 25/233 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VA++ ++ V LLER AH + L +LL G + +
Sbjct: 572 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-S 630
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
YT LHIA +NQ ++ L+ +G N + + +PL LA++E + LL
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN-AESVQGVTPLHLAAQE-GHAEMVALLL 688
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTV----- 213
A+ N +K G T LH +A V + + +L++ G V ATT+ G T
Sbjct: 689 SKQANGNLGNKSGLTP-LHLVAQEGHVPVAD-----VLIKHGVMVDATTRMGYTPLHVAS 742
Query: 214 ----FTCIIFLL-------GETVGGDKEEAQMINRFCFQVTRLLLAHGADPSE 255
+ FLL +T G Q + + LLL +GA P+E
Sbjct: 743 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795
Score = 46.2 bits (108), Expect = 6e-05
Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 2/75 (2%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADV 164
TALHIA L Q ++V LV++GA+VN + + +PL +A++E L ++ LL+ GA+
Sbjct: 113 TALHIAALAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQE-NHLEVVKFLLENGANQ 170
Query: 165 NAADKHGKTALLHAL 179
N A + G T L AL
Sbjct: 171 NVATEDGFTPLAVAL 185
Score = 45.1 bits (105), Expect = 1e-04
Identities = 64/250 (25%), Positives = 98/250 (39%), Gaps = 27/250 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VAS + ++ LL+R A V L A G T A LL++ A +N +
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 499
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
T LH A +MV+LL+ + A+ N +PL +A+ E + + LL
Sbjct: 500 -AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH-TPLHIAARE-GHVETVLALL 556
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ A K G T LH A V++ LLLE A A K+G T
Sbjct: 557 EKEASQACMTKKGFTP-LHVAAKYGKVRV-----AELLLERDAHPNAAGKNGLTPLHV-- 608
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
++ + +LLL G P PA T + + + + + R
Sbjct: 609 ---------------AVHHNNLDIVKLLLPRGGSP-HSPAWNGYTPLHIAAKQNQVEVAR 652
Query: 279 FLLESGAAYN 288
LL+ G + N
Sbjct: 653 SLLQYGGSAN 662
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 9/174 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++++++ V LL+ + L A+ G +LL AN N
Sbjct: 638 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 697
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ + T LH+ + ++L+ HG V+ R+ + PL +AS + ++ LL
Sbjct: 698 NK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT-PLHVASHYGN-IKLVKFLL 754
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
ADVNA K G + L A Q +T+ + LLL+ GA + DG T
Sbjct: 755 QHQADVNAKTKLGYSPLHQA------AQQGHTDIVTLLLKNGASPNEVSSDGTT 802
Score = 32.7 bits (73), Expect = 0.63
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 24/128 (18%)
Query: 161 GADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFL 220
G D+N +++G L LAS +G + + + LL ++ TTK G+T I L
Sbjct: 68 GVDINTCNQNGLNGL--HLASKEG----HVKMVVELLHKEIILETTTKKGNTALH-IAAL 120
Query: 221 LGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFL 280
G+ +V R L+ +GA+ + + + T + + + + H +++FL
Sbjct: 121 AGQD----------------EVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFL 163
Query: 281 LESGAAYN 288
LE+GA N
Sbjct: 164 LENGANQN 171
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 62.4 bits (150), Expect = 7e-10
Identities = 66/222 (29%), Positives = 99/222 (44%), Gaps = 26/222 (11%)
Query: 85 ADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA 144
A +LL GA++NF P T LHIA R MV LL+ GA + + + E +PL A
Sbjct: 222 AQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHCA 279
Query: 145 SEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVK 204
+ + + LLD GA + A K+G + + H A D + + +RLLL+ A++
Sbjct: 280 ARNGH-VRISEILLDHGAPIQAKTKNGLSPI-HMAAQGD-----HLDCVRLLLQYDAEID 332
Query: 205 ATTKDGDTVFTCIIFLLGETVG------GDKEEAQMINRFC----------FQVTRLLLA 248
T D T V G K ++ +N F +V LLL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 249 HGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCS 290
GA + LT + + SF H P+++ LL+ GA+ N S
Sbjct: 393 TGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Score = 53.5 bits (127), Expect = 3e-07
Identities = 65/216 (30%), Positives = 95/216 (43%), Gaps = 33/216 (15%)
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIH 136
A G R A VLL GA N + +T LHIA +N ++ELL+ GA + D +
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVT 401
Query: 137 ES--SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIR 194
ES +PL +AS LP ++ LL GA N ++ +T L A + +TE +
Sbjct: 402 ESGLTPLHVAS-FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG------HTEVAK 454
Query: 195 LLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPS 254
LL+ A V A KD T C +G T + +LLL + A+P+
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAA-RIGHT----------------NMVKLLLENNANPN 497
Query: 255 -ECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNC 289
A + HI + + H + LLE A+ C
Sbjct: 498 LATTAGHTPLHIAAR--EGHVETVLALLEKEASQAC 531
Score = 51.6 bits (122), Expect = 1e-06
Identities = 64/247 (25%), Positives = 102/247 (41%), Gaps = 31/247 (12%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P Y+A++E+ + V+ LLE A+ E L + G L+ +G
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
P ALHIA + +L+ + + + + +PL +A+ E L Q LL
Sbjct: 174 LP-----ALHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHY-ENLNVAQLLL 226
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ GA VN ++G T L +AS G N +RLLL+ GA ++ TKD T C
Sbjct: 227 NRGASVNFTPQNGITPL--HIASRRG----NVIMVRLLLDRGAQIETKTKDELTPLHC-- 278
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
+++ +LL HGA P + L+ I + + H +R
Sbjct: 279 ---------------AARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 279 FLLESGA 285
LL+ A
Sbjct: 323 LLLQYDA 329
Score = 50.1 bits (118), Expect = 4e-06
Identities = 39/137 (28%), Positives = 67/137 (48%), Gaps = 3/137 (2%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++E ++ LL ++A+ + L +A+ G ADVL++HG ++
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ YT LH+A +V+ L+ H ADVN + ++ SPL A+++ + LL
Sbjct: 698 TRMG-YTPLHVASHYGNIKLVKFLLQHQADVNAKTKL-GYSPLHQAAQQ-GHTDIVTLLL 754
Query: 159 DLGADVNAADKHGKTAL 175
GA N G T L
Sbjct: 755 KNGASPNEVSSDGTTPL 771
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 25/233 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VA++ ++ V LLER AH + L +LL G + +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-S 597
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
YT LHIA +NQ ++ L+ +G N + + +PL LA++E + LL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN-AESVQGVTPLHLAAQE-GHAEMVALLL 655
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTV----- 213
A+ N +K G T LH +A V + + +L++ G V ATT+ G T
Sbjct: 656 SKQANGNLGNKSGLTP-LHLVAQEGHVPVAD-----VLIKHGVMVDATTRMGYTPLHVAS 709
Query: 214 ----FTCIIFLL-------GETVGGDKEEAQMINRFCFQVTRLLLAHGADPSE 255
+ FLL +T G Q + + LLL +GA P+E
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Score = 46.2 bits (108), Expect = 6e-05
Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 2/75 (2%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADV 164
TALHIA L Q ++V LV++GA+VN + + +PL +A++E L ++ LL+ GA+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQE-NHLEVVKFLLENGANQ 137
Query: 165 NAADKHGKTALLHAL 179
N A + G T L AL
Sbjct: 138 NVATEDGFTPLAVAL 152
Score = 45.1 bits (105), Expect = 1e-04
Identities = 64/250 (25%), Positives = 98/250 (39%), Gaps = 27/250 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VAS + ++ LL+R A V L A G T A LL++ A +N +
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
T LH A +MV+LL+ + A+ N +PL +A+ E + + LL
Sbjct: 467 -AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH-TPLHIAARE-GHVETVLALL 523
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ A K G T LH A V++ LLLE A A K+G T
Sbjct: 524 EKEASQACMTKKGFTP-LHVAAKYGKVRV-----AELLLERDAHPNAAGKNGLTPLHV-- 575
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
++ + +LLL G P PA T + + + + + R
Sbjct: 576 ---------------AVHHNNLDIVKLLLPRGGSP-HSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 279 FLLESGAAYN 288
LL+ G + N
Sbjct: 620 SLLQYGGSAN 629
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 9/174 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++++++ V LL+ + L A+ G +LL AN N
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ + T LH+ + ++L+ HG V+ R+ + PL +AS + ++ LL
Sbjct: 665 NK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT-PLHVASHYGN-IKLVKFLL 721
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
ADVNA K G + L A Q +T+ + LLL+ GA + DG T
Sbjct: 722 QHQADVNAKTKLGYSPLHQA------AQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Score = 32.7 bits (73), Expect = 0.63
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 24/128 (18%)
Query: 161 GADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFL 220
G D+N +++G L LAS +G + + + LL ++ TTK G+T I L
Sbjct: 35 GVDINTCNQNGLNGL--HLASKEG----HVKMVVELLHKEIILETTTKKGNTALH-IAAL 87
Query: 221 LGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFL 280
G+ +V R L+ +GA+ + + + T + + + + H +++FL
Sbjct: 88 AGQD----------------EVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 281 LESGAAYN 288
LE+GA N
Sbjct: 131 LENGANQN 138
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 62.4 bits (150), Expect = 7e-10
Identities = 66/222 (29%), Positives = 99/222 (44%), Gaps = 26/222 (11%)
Query: 85 ADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA 144
A +LL GA++NF P T LHIA R MV LL+ GA + + + E +PL A
Sbjct: 222 AQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHCA 279
Query: 145 SEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVK 204
+ + + LLD GA + A K+G + + H A D + + +RLLL+ A++
Sbjct: 280 ARNGH-VRISEILLDHGAPIQAKTKNGLSPI-HMAAQGD-----HLDCVRLLLQYDAEID 332
Query: 205 ATTKDGDTVFTCIIFLLGETVG------GDKEEAQMINRFC----------FQVTRLLLA 248
T D T V G K ++ +N F +V LLL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 249 HGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCS 290
GA + LT + + SF H P+++ LL+ GA+ N S
Sbjct: 393 TGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Score = 53.5 bits (127), Expect = 3e-07
Identities = 65/216 (30%), Positives = 95/216 (43%), Gaps = 33/216 (15%)
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIH 136
A G R A VLL GA N + +T LHIA +N ++ELL+ GA + D +
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVT 401
Query: 137 ES--SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIR 194
ES +PL +AS LP ++ LL GA N ++ +T L A + +TE +
Sbjct: 402 ESGLTPLHVAS-FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG------HTEVAK 454
Query: 195 LLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPS 254
LL+ A V A KD T C +G T + +LLL + A+P+
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAA-RIGHT----------------NMVKLLLENNANPN 497
Query: 255 -ECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNC 289
A + HI + + H + LLE A+ C
Sbjct: 498 LATTAGHTPLHIAAR--EGHVETVLALLEKEASQAC 531
Score = 51.6 bits (122), Expect = 1e-06
Identities = 64/247 (25%), Positives = 102/247 (41%), Gaps = 31/247 (12%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P Y+A++E+ + V+ LLE A+ E L + G L+ +G
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
P ALHIA + +L+ + + + + +PL +A+ E L Q LL
Sbjct: 174 LP-----ALHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHY-ENLNVAQLLL 226
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ GA VN ++G T L +AS G N +RLLL+ GA ++ TKD T C
Sbjct: 227 NRGASVNFTPQNGITPL--HIASRRG----NVIMVRLLLDRGAQIETKTKDELTPLHC-- 278
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
+++ +LL HGA P + L+ I + + H +R
Sbjct: 279 ---------------AARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 279 FLLESGA 285
LL+ A
Sbjct: 323 LLLQYDA 329
Score = 50.1 bits (118), Expect = 4e-06
Identities = 39/137 (28%), Positives = 67/137 (48%), Gaps = 3/137 (2%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++E ++ LL ++A+ + L +A+ G ADVL++HG ++
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ YT LH+A +V+ L+ H ADVN + ++ SPL A+++ + LL
Sbjct: 698 TRMG-YTPLHVASHYGNIKLVKFLLQHQADVNAKTKL-GYSPLHQAAQQ-GHTDIVTLLL 754
Query: 159 DLGADVNAADKHGKTAL 175
GA N G T L
Sbjct: 755 KNGASPNEVSSDGTTPL 771
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 25/233 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VA++ ++ V LLER AH + L +LL G + +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-S 597
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
YT LHIA +NQ ++ L+ +G N + + +PL LA++E + LL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN-AESVQGVTPLHLAAQE-GHAEMVALLL 655
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTV----- 213
A+ N +K G T LH +A V + + +L++ G V ATT+ G T
Sbjct: 656 SKQANGNLGNKSGLTP-LHLVAQEGHVPVAD-----VLIKHGVMVDATTRMGYTPLHVAS 709
Query: 214 ----FTCIIFLL-------GETVGGDKEEAQMINRFCFQVTRLLLAHGADPSE 255
+ FLL +T G Q + + LLL +GA P+E
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Score = 46.2 bits (108), Expect = 6e-05
Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 2/75 (2%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADV 164
TALHIA L Q ++V LV++GA+VN + + +PL +A++E L ++ LL+ GA+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQE-NHLEVVKFLLENGANQ 137
Query: 165 NAADKHGKTALLHAL 179
N A + G T L AL
Sbjct: 138 NVATEDGFTPLAVAL 152
Score = 45.1 bits (105), Expect = 1e-04
Identities = 64/250 (25%), Positives = 98/250 (39%), Gaps = 27/250 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VAS + ++ LL+R A V L A G T A LL++ A +N +
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
T LH A +MV+LL+ + A+ N +PL +A+ E + + LL
Sbjct: 467 -AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH-TPLHIAARE-GHVETVLALL 523
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ A K G T LH A V++ LLLE A A K+G T
Sbjct: 524 EKEASQACMTKKGFTP-LHVAAKYGKVRV-----AELLLERDAHPNAAGKNGLTPLHV-- 575
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
++ + +LLL G P PA T + + + + + R
Sbjct: 576 ---------------AVHHNNLDIVKLLLPRGGSP-HSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 279 FLLESGAAYN 288
LL+ G + N
Sbjct: 620 SLLQYGGSAN 629
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 9/174 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++++++ V LL+ + L A+ G +LL AN N
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ + T LH+ + ++L+ HG V+ R+ + PL +AS + ++ LL
Sbjct: 665 NK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT-PLHVASHYGN-IKLVKFLL 721
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
ADVNA K G + L A Q +T+ + LLL+ GA + DG T
Sbjct: 722 QHQADVNAKTKLGYSPLHQA------AQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Score = 32.7 bits (73), Expect = 0.63
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 24/128 (18%)
Query: 161 GADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFL 220
G D+N +++G L LAS +G + + + LL ++ TTK G+T I L
Sbjct: 35 GVDINTCNQNGLNGL--HLASKEG----HVKMVVELLHKEIILETTTKKGNTALH-IAAL 87
Query: 221 LGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFL 280
G+ +V R L+ +GA+ + + + T + + + + H +++FL
Sbjct: 88 AGQD----------------EVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 281 LESGAAYN 288
LE+GA N
Sbjct: 131 LENGANQN 138
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 62.4 bits (150), Expect = 7e-10
Identities = 66/222 (29%), Positives = 99/222 (44%), Gaps = 26/222 (11%)
Query: 85 ADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA 144
A +LL GA++NF P T LHIA R MV LL+ GA + + + E +PL A
Sbjct: 222 AQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHCA 279
Query: 145 SEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVK 204
+ + + LLD GA + A K+G + + H A D + + +RLLL+ A++
Sbjct: 280 ARNGH-VRISEILLDHGAPIQAKTKNGLSPI-HMAAQGD-----HLDCVRLLLQYDAEID 332
Query: 205 ATTKDGDTVFTCIIFLLGETVG------GDKEEAQMINRFC----------FQVTRLLLA 248
T D T V G K ++ +N F +V LLL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 249 HGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCS 290
GA + LT + + SF H P+++ LL+ GA+ N S
Sbjct: 393 TGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Score = 53.5 bits (127), Expect = 3e-07
Identities = 65/216 (30%), Positives = 95/216 (43%), Gaps = 33/216 (15%)
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIH 136
A G R A VLL GA N + +T LHIA +N ++ELL+ GA + D +
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVT 401
Query: 137 ES--SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIR 194
ES +PL +AS LP ++ LL GA N ++ +T L A + +TE +
Sbjct: 402 ESGLTPLHVAS-FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG------HTEVAK 454
Query: 195 LLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPS 254
LL+ A V A KD T C +G T + +LLL + A+P+
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAA-RIGHT----------------NMVKLLLENNANPN 497
Query: 255 -ECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNC 289
A + HI + + H + LLE A+ C
Sbjct: 498 LATTAGHTPLHIAAR--EGHVETVLALLEKEASQAC 531
Score = 51.6 bits (122), Expect = 1e-06
Identities = 64/247 (25%), Positives = 102/247 (41%), Gaps = 31/247 (12%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P Y+A++E+ + V+ LLE A+ E L + G L+ +G
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
P ALHIA + +L+ + + + + +PL +A+ E L Q LL
Sbjct: 174 LP-----ALHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHY-ENLNVAQLLL 226
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ GA VN ++G T L +AS G N +RLLL+ GA ++ TKD T C
Sbjct: 227 NRGASVNFTPQNGITPL--HIASRRG----NVIMVRLLLDRGAQIETKTKDELTPLHC-- 278
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
+++ +LL HGA P + L+ I + + H +R
Sbjct: 279 ---------------AARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 279 FLLESGA 285
LL+ A
Sbjct: 323 LLLQYDA 329
Score = 50.1 bits (118), Expect = 4e-06
Identities = 39/137 (28%), Positives = 67/137 (48%), Gaps = 3/137 (2%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++E ++ LL ++A+ + L +A+ G ADVL++HG ++
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ YT LH+A +V+ L+ H ADVN + ++ SPL A+++ + LL
Sbjct: 698 TRMG-YTPLHVASHYGNIKLVKFLLQHQADVNAKTKL-GYSPLHQAAQQ-GHTDIVTLLL 754
Query: 159 DLGADVNAADKHGKTAL 175
GA N G T L
Sbjct: 755 KNGASPNEVSSDGTTPL 771
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 25/233 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VA++ ++ V LLER AH + L +LL G + +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-S 597
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
YT LHIA +NQ ++ L+ +G N + + +PL LA++E + LL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN-AESVQGVTPLHLAAQE-GHAEMVALLL 655
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTV----- 213
A+ N +K G T LH +A V + + +L++ G V ATT+ G T
Sbjct: 656 SKQANGNLGNKSGLTP-LHLVAQEGHVPVAD-----VLIKHGVMVDATTRMGYTPLHVAS 709
Query: 214 ----FTCIIFLL-------GETVGGDKEEAQMINRFCFQVTRLLLAHGADPSE 255
+ FLL +T G Q + + LLL +GA P+E
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Score = 46.2 bits (108), Expect = 6e-05
Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 2/75 (2%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADV 164
TALHIA L Q ++V LV++GA+VN + + +PL +A++E L ++ LL+ GA+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQE-NHLEVVKFLLENGANQ 137
Query: 165 NAADKHGKTALLHAL 179
N A + G T L AL
Sbjct: 138 NVATEDGFTPLAVAL 152
Score = 45.1 bits (105), Expect = 1e-04
Identities = 64/250 (25%), Positives = 98/250 (39%), Gaps = 27/250 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VAS + ++ LL+R A V L A G T A LL++ A +N +
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
T LH A +MV+LL+ + A+ N +PL +A+ E + + LL
Sbjct: 467 -AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH-TPLHIAARE-GHVETVLALL 523
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ A K G T LH A V++ LLLE A A K+G T
Sbjct: 524 EKEASQACMTKKGFTP-LHVAAKYGKVRV-----AELLLERDAHPNAAGKNGLTPLHV-- 575
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
++ + +LLL G P PA T + + + + + R
Sbjct: 576 ---------------AVHHNNLDIVKLLLPRGGSP-HSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 279 FLLESGAAYN 288
LL+ G + N
Sbjct: 620 SLLQYGGSAN 629
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 9/174 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++++++ V LL+ + L A+ G +LL AN N
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ + T LH+ + ++L+ HG V+ R+ + PL +AS + ++ LL
Sbjct: 665 NK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT-PLHVASHYGN-IKLVKFLL 721
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
ADVNA K G + L A Q +T+ + LLL+ GA + DG T
Sbjct: 722 QHQADVNAKTKLGYSPLHQA------AQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Score = 32.7 bits (73), Expect = 0.63
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 24/128 (18%)
Query: 161 GADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFL 220
G D+N +++G L LAS +G + + + LL ++ TTK G+T I L
Sbjct: 35 GVDINTCNQNGLNGL--HLASKEG----HVKMVVELLHKEIILETTTKKGNTALH-IAAL 87
Query: 221 LGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFL 280
G+ +V R L+ +GA+ + + + T + + + + H +++FL
Sbjct: 88 AGQD----------------EVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 281 LESGAAYN 288
LE+GA N
Sbjct: 131 LENGANQN 138
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 62.4 bits (150), Expect = 7e-10
Identities = 66/222 (29%), Positives = 99/222 (44%), Gaps = 26/222 (11%)
Query: 85 ADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLA 144
A +LL GA++NF P T LHIA R MV LL+ GA + + + E +PL A
Sbjct: 222 AQLLLNRGASVNFT-PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTK-DELTPLHCA 279
Query: 145 SEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVK 204
+ + + LLD GA + A K+G + + H A D + + +RLLL+ A++
Sbjct: 280 ARNGH-VRISEILLDHGAPIQAKTKNGLSPI-HMAAQGD-----HLDCVRLLLQYDAEID 332
Query: 205 ATTKDGDTVFTCIIFLLGETVG------GDKEEAQMINRFC----------FQVTRLLLA 248
T D T V G K ++ +N F +V LLL
Sbjct: 333 DITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Query: 249 HGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNCS 290
GA + LT + + SF H P+++ LL+ GA+ N S
Sbjct: 393 TGAS-IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Score = 53.5 bits (127), Expect = 3e-07
Identities = 65/216 (30%), Positives = 95/216 (43%), Gaps = 33/216 (15%)
Query: 77 AELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIH 136
A G R A VLL GA N + +T LHIA +N ++ELL+ GA + D +
Sbjct: 346 AHCGHHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASI---DAVT 401
Query: 137 ES--SPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIR 194
ES +PL +AS LP ++ LL GA N ++ +T L A + +TE +
Sbjct: 402 ESGLTPLHVAS-FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG------HTEVAK 454
Query: 195 LLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPS 254
LL+ A V A KD T C +G T + +LLL + A+P+
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAA-RIGHT----------------NMVKLLLENNANPN 497
Query: 255 -ECPAHESLTHICLKSFKLHFPLLRFLLESGAAYNC 289
A + HI + + H + LLE A+ C
Sbjct: 498 LATTAGHTPLHIAAR--EGHVETVLALLEKEASQAC 531
Score = 51.6 bits (122), Expect = 1e-06
Identities = 64/247 (25%), Positives = 102/247 (41%), Gaps = 31/247 (12%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P Y+A++E+ + V+ LLE A+ E L + G L+ +G
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
P ALHIA + +L+ + + + + +PL +A+ E L Q LL
Sbjct: 174 LP-----ALHIAARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHY-ENLNVAQLLL 226
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ GA VN ++G T L +AS G N +RLLL+ GA ++ TKD T C
Sbjct: 227 NRGASVNFTPQNGITPL--HIASRRG----NVIMVRLLLDRGAQIETKTKDELTPLHC-- 278
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
+++ +LL HGA P + L+ I + + H +R
Sbjct: 279 ---------------AARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVR 322
Query: 279 FLLESGA 285
LL+ A
Sbjct: 323 LLLQYDA 329
Score = 50.1 bits (118), Expect = 4e-06
Identities = 39/137 (28%), Positives = 67/137 (48%), Gaps = 3/137 (2%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++E ++ LL ++A+ + L +A+ G ADVL++HG ++
Sbjct: 638 PLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ YT LH+A +V+ L+ H ADVN + ++ SPL A+++ + LL
Sbjct: 698 TRMG-YTPLHVASHYGNIKLVKFLLQHQADVNAKTKL-GYSPLHQAAQQ-GHTDIVTLLL 754
Query: 159 DLGADVNAADKHGKTAL 175
GA N G T L
Sbjct: 755 KNGASPNEVSSDGTTPL 771
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/233 (26%), Positives = 97/233 (41%), Gaps = 25/233 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VA++ ++ V LLER AH + L +LL G + +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-S 597
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
YT LHIA +NQ ++ L+ +G N + + +PL LA++E + LL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN-AESVQGVTPLHLAAQE-GHAEMVALLL 655
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTV----- 213
A+ N +K G T LH +A V + + +L++ G V ATT+ G T
Sbjct: 656 SKQANGNLGNKSGLTP-LHLVAQEGHVPVAD-----VLIKHGVMVDATTRMGYTPLHVAS 709
Query: 214 ----FTCIIFLL-------GETVGGDKEEAQMINRFCFQVTRLLLAHGADPSE 255
+ FLL +T G Q + + LLL +GA P+E
Sbjct: 710 HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Score = 46.2 bits (108), Expect = 6e-05
Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 2/75 (2%)
Query: 105 TALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADV 164
TALHIA L Q ++V LV++GA+VN + + +PL +A++E L ++ LL+ GA+
Sbjct: 80 TALHIAALAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQE-NHLEVVKFLLENGANQ 137
Query: 165 NAADKHGKTALLHAL 179
N A + G T L AL
Sbjct: 138 NVATEDGFTPLAVAL 152
Score = 45.1 bits (105), Expect = 1e-04
Identities = 64/250 (25%), Positives = 98/250 (39%), Gaps = 27/250 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VAS + ++ LL+R A V L A G T A LL++ A +N +
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
T LH A +MV+LL+ + A+ N +PL +A+ E + + LL
Sbjct: 467 -AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH-TPLHIAARE-GHVETVLALL 523
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII 218
+ A K G T LH A V++ LLLE A A K+G T
Sbjct: 524 EKEASQACMTKKGFTP-LHVAAKYGKVRV-----AELLLERDAHPNAAGKNGLTPLHV-- 575
Query: 219 FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLR 278
++ + +LLL G P PA T + + + + + R
Sbjct: 576 ---------------AVHHNNLDIVKLLLPRGGSP-HSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 279 FLLESGAAYN 288
LL+ G + N
Sbjct: 620 SLLQYGGSAN 629
Score = 45.1 bits (105), Expect = 1e-04
Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 9/174 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++++++ V LL+ + L A+ G +LL AN N
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ + T LH+ + ++L+ HG V+ R+ + PL +AS + ++ LL
Sbjct: 665 NK-SGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYT-PLHVASHYGN-IKLVKFLL 721
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
ADVNA K G + L A Q +T+ + LLL+ GA + DG T
Sbjct: 722 QHQADVNAKTKLGYSPLHQA------AQQGHTDIVTLLLKNGASPNEVSSDGTT 769
Score = 32.7 bits (73), Expect = 0.63
Identities = 33/128 (25%), Positives = 60/128 (46%), Gaps = 24/128 (18%)
Query: 161 GADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFL 220
G D+N +++G L LAS +G + + + LL ++ TTK G+T I L
Sbjct: 35 GVDINTCNQNGLNGL--HLASKEG----HVKMVVELLHKEIILETTTKKGNTALH-IAAL 87
Query: 221 LGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFL 280
G+ +V R L+ +GA+ + + + T + + + + H +++FL
Sbjct: 88 AGQD----------------EVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFL 130
Query: 281 LESGAAYN 288
LE+GA N
Sbjct: 131 LENGANQN 138
>gi|10863929 ribonuclease L [Homo sapiens]
Length = 741
Score = 62.0 bits (149), Expect = 1e-09
Identities = 68/233 (29%), Positives = 98/233 (42%), Gaps = 54/233 (23%)
Query: 88 LLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEE 147
LL GAN+NF++ +T LH AV ++ D+VELL+ HGAD R + + ++P LA+
Sbjct: 44 LLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKK-NGATPFILAAIA 102
Query: 148 PERLPCLQRLLDLGADVNAADKHGKTALLH------------------------------ 177
+ L+ L GADVN D +G TA +
Sbjct: 103 GS-VKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQ 161
Query: 178 -------ALASSDGVQIHNTENIRLLL-EGGADVKATTKDGDTVFTCIIFLLGETVGGDK 229
A A D + + E +++LL E GADV A G L+ + D
Sbjct: 162 ERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNA------LIHALLSSDD 215
Query: 230 EEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLE 282
+ + I T LLL HGAD + T + L K H L++ LLE
Sbjct: 216 SDVEAI-------THLLLDHGADVN-VRGERGKTPLILAVEKKHLGLVQRLLE 260
Score = 47.0 bits (110), Expect = 3e-05
Identities = 54/212 (25%), Positives = 91/212 (42%), Gaps = 28/212 (13%)
Query: 72 ALLKMAELGLTRAADVLLRHGANLNF-----EDPVTYY----TALHIAVLRNQPDMVELL 122
A ++ A G +A L + GAN+N ED TAL A + +++++L
Sbjct: 128 AFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKIL 187
Query: 123 VHH-GADVNRRDRIHESSPLD--LASEEPERLPCLQRLLDLGADVNAADKHGKTALLHAL 179
+ GADVN D + ++ + L+S++ + LLD GADVN + GKT L+ A+
Sbjct: 188 LDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAV 247
Query: 180 ASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETV-------GGDKEEA 232
H RLL + ++ T DG T + L + + G +
Sbjct: 248 EKK-----HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCG 302
Query: 233 QMI----NRFCFQVTRLLLAHGADPSECPAHE 260
++ + + ++LL+HGA P E
Sbjct: 303 DLVMTARRNYDHSLVKVLLSHGAKEDFHPPAE 334
Score = 33.9 bits (76), Expect = 0.28
Identities = 34/106 (32%), Positives = 50/106 (47%), Gaps = 9/106 (8%)
Query: 110 AVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADK 169
AV D+V+ L+ GA+VN ++ +PL A + R ++ LL GAD K
Sbjct: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNA-VQMSREDIVELLLRHGADPVLRKK 90
Query: 170 HGKTA-LLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVF 214
+G T +L A+A S + ++L L GADV G T F
Sbjct: 91 NGATPFILAAIAGS-------VKLLKLFLSKGADVNECDFYGFTAF 129
Score = 30.8 bits (68), Expect = 2.4
Identities = 31/110 (28%), Positives = 44/110 (40%), Gaps = 18/110 (16%)
Query: 185 VQIHNTENIRLLLEGGADVKATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFCFQVTR 244
VQ + + ++ LLEGGA+V ++G L V +E+ +
Sbjct: 33 VQNEDVDLVQQLLEGGANVNFQEEEGGWT------PLHNAVQMSRED----------IVE 76
Query: 245 LLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESGAAYN-CSLHG 293
LLL HGADP T L + LL+ L GA N C +G
Sbjct: 77 LLLRHGADP-VLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYG 125
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 61.6 bits (148), Expect = 1e-09
Identities = 54/195 (27%), Positives = 95/195 (48%), Gaps = 9/195 (4%)
Query: 18 VDAILGSLGIQDPERQESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMA 77
V +L S G + + + P + A+ V L E + LL +
Sbjct: 460 VAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTAS 519
Query: 78 ELGLTRAADVLLRHGANLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHE 137
G + L HGA+LN D + ALH+AV R Q ++++ L+ G V+ +DR H
Sbjct: 520 ARGYHDIVECLAEHGADLNACDK-DGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDR-HG 577
Query: 138 SSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLL 197
++PL +A ++ +P + L + +++ ++K+G+T L LA+++G+ + +R L
Sbjct: 578 NTPLHVACKD-GNMPIVVALCEANCNLDISNKYGRTPL--HLAANNGI----LDVVRYLC 630
Query: 198 EGGADVKATTKDGDT 212
GA V+A T DG T
Sbjct: 631 LMGASVEALTTDGKT 645
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 61.6 bits (148), Expect = 1e-09
Identities = 69/237 (29%), Positives = 108/237 (45%), Gaps = 25/237 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VA++ + V LL+R+A + + L A + A +LL GA+ +
Sbjct: 545 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH-A 603
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
YT LHIA +NQ + L+++GA+ N + +PL LAS+E + LL
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK-QGVTPLHLASQE-GHTDMVTLLL 661
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT--VFTC 216
D GA+++ + K G T+ LH A D V + + +L + GAD A TK G T + C
Sbjct: 662 DKGANIHMSTKSGLTS-LHLAAQEDKVNVAD-----ILTKHGADQDAHTKLGYTPLIVAC 715
Query: 217 -------IIFLL-------GETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAH 259
+ FLL +T G Q + + +LL HGA P+ A+
Sbjct: 716 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTAN 772
Score = 58.9 bits (141), Expect = 8e-09
Identities = 49/174 (28%), Positives = 89/174 (51%), Gaps = 9/174 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++++++ + + LL A + + L ++ G T +LL GAN++
Sbjct: 611 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 670
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ T+LH+A ++ ++ ++L HGAD + ++ + PL +A + + LL
Sbjct: 671 TK-SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT-PLIVACHYGN-VKMVNFLL 727
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
GA+VNA K+G T L A Q +T I +LL+ GA ATT +G+T
Sbjct: 728 KQGANVNAKTKNGYTPLHQA------AQQGHTHIINVLLQHGAKPNATTANGNT 775
Score = 55.8 bits (133), Expect = 7e-08
Identities = 70/252 (27%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++ + + LL+ KA AL A G R +LL AN N
Sbjct: 314 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 373
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHES--SPLDLASEEPERLPCLQR 156
+ +T LHIA +N+ ++ELLV +GA + I ES +P+ +A+ L +
Sbjct: 374 -ALNGFTPLHIACKKNRIKVMELLVKYGASI---QAITESGLTPIHVAA-FMGHLNIVLL 428
Query: 157 LLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTC 216
LL GA + + G+TA LH A + V++ +R LL GA V A ++ T
Sbjct: 429 LLQNGASPDVTNIRGETA-LHMAARAGQVEV-----VRCLLRNGALVDARAREEQTPLH- 481
Query: 217 IIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPL 276
I LG+T ++ +LLL H A P + T + + + + +
Sbjct: 482 IASRLGKT----------------EIVQLLLQHMAHP-DAATTNGYTPLHISAREGQVDV 524
Query: 277 LRFLLESGAAYN 288
LLE+GAA++
Sbjct: 525 ASVLLEAGAAHS 536
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/185 (29%), Positives = 85/185 (45%), Gaps = 19/185 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P Y+A++E+ I V+ LLE A+ E L + G +A +LL +
Sbjct: 112 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 171
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVH--HGADVNRRDRIHESS-----PLDLASEEPERL 151
P ALHIA ++ LL+ H ADV + ++ ++ PL +A+ +
Sbjct: 172 LP-----ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN-V 225
Query: 152 PCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGD 211
LL+ GA V+ ++G T L +AS G NT ++LLL+ G + A T+DG
Sbjct: 226 NVATLLLNRGAAVDFTARNGITPL--HVASKRG----NTNMVKLLLDRGGQIDAKTRDGL 279
Query: 212 TVFTC 216
T C
Sbjct: 280 TPLHC 284
Score = 48.1 bits (113), Expect = 1e-05
Identities = 68/239 (28%), Positives = 108/239 (45%), Gaps = 40/239 (16%)
Query: 71 NALLKMAELGLTRAADVLLRHGANLNFEDPVTYY--TALHIAVLRNQPDMVELLVHHGAD 128
NAL A+ G LL G+++ D T TALHIA L Q ++V++LV GA+
Sbjct: 45 NALHLAAKEGHVGLVQELLGRGSSV---DSATKKGNTALHIASLAGQAEVVKVLVKEGAN 101
Query: 129 VNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIH 188
+N + + + +PL +A++E + ++ LL+ GA+ + A + G T L AL Q H
Sbjct: 102 INAQSQ-NGFTPLYMAAQE-NHIDVVKYLLENGANQSTATEDGFTPLAVALQ-----QGH 154
Query: 189 NTENIRLLLEGGADVK--------ATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFC- 239
N + + +LLE K A KD DT + LL D + M+NR
Sbjct: 155 N-QAVAILLENDTKGKVRLPALHIAARKD-DTKSAAL--LLQNDHNADVQSKMMVNRTTE 210
Query: 240 --------------FQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESG 284
V LLL GA + A +T + + S + + +++ LL+ G
Sbjct: 211 SGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Score = 46.2 bits (108), Expect = 6e-05
Identities = 66/253 (26%), Positives = 106/253 (41%), Gaps = 27/253 (10%)
Query: 34 ESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGA 93
ES P ++A+ + V T LL R A F L ++ G T +LL G
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 269
Query: 94 NLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPC 153
++ + T LH A +VELL+ GA + R + + SPL +A+ + + + C
Sbjct: 270 QIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAA-QGDHVEC 326
Query: 154 LQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTV 213
++ LL A V+ TA LH A ++ +LLL+ A+ A +G T
Sbjct: 327 VKHLLQHKAPVDDVTLDYLTA-LHVAAHCGHYRV-----TKLLLDKRANPNARALNGFTP 380
Query: 214 FTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLH 273
A NR +V LL+ +GA + LT I + +F H
Sbjct: 381 L---------------HIACKKNR--IKVMELLVKYGAS-IQAITESGLTPIHVAAFMGH 422
Query: 274 FPLLRFLLESGAA 286
++ LL++GA+
Sbjct: 423 LNIVLLLLQNGAS 435
Score = 37.4 bits (85), Expect = 0.026
Identities = 48/182 (26%), Positives = 85/182 (46%), Gaps = 25/182 (13%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
++A++E + ++ ELL R + + + AL + G VL++ GAN+N +
Sbjct: 48 HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 107
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDL 160
+T L++A N D+V+ L+ +GA+ + +PL +A ++ + LL+
Sbjct: 108 -NGFTPLYMAAQENHIDVVKYLLENGANQSTATE-DGFTPLAVALQQGHN-QAVAILLE- 163
Query: 161 GADVNAADKHGKTAL--LHALASSDGVQIHNTENIRLLLEG--GADVKA------TTKDG 210
D GK L LH A D +T++ LLL+ ADV++ TT+ G
Sbjct: 164 ------NDTKGKVRLPALHIAARKD-----DTKSAALLLQNDHNADVQSKMMVNRTTESG 212
Query: 211 DT 212
T
Sbjct: 213 FT 214
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 61.6 bits (148), Expect = 1e-09
Identities = 69/237 (29%), Positives = 108/237 (45%), Gaps = 25/237 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VA++ + V LL+R+A + + L A + A +LL GA+ +
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH-A 624
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
YT LHIA +NQ + L+++GA+ N + +PL LAS+E + LL
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK-QGVTPLHLASQE-GHTDMVTLLL 682
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT--VFTC 216
D GA+++ + K G T+ LH A D V + + +L + GAD A TK G T + C
Sbjct: 683 DKGANIHMSTKSGLTS-LHLAAQEDKVNVAD-----ILTKHGADQDAHTKLGYTPLIVAC 736
Query: 217 -------IIFLL-------GETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAH 259
+ FLL +T G Q + + +LL HGA P+ A+
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTAN 793
Score = 58.9 bits (141), Expect = 8e-09
Identities = 49/174 (28%), Positives = 89/174 (51%), Gaps = 9/174 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++++++ + + LL A + + L ++ G T +LL GAN++
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ T+LH+A ++ ++ ++L HGAD + ++ + PL +A + + LL
Sbjct: 692 TK-SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT-PLIVACHYGN-VKMVNFLL 748
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
GA+VNA K+G T L A Q +T I +LL+ GA ATT +G+T
Sbjct: 749 KQGANVNAKTKNGYTPLHQA------AQQGHTHIINVLLQHGAKPNATTANGNT 796
Score = 55.8 bits (133), Expect = 7e-08
Identities = 70/252 (27%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++ + + LL+ KA AL A G R +LL AN N
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHES--SPLDLASEEPERLPCLQR 156
+ +T LHIA +N+ ++ELLV +GA + I ES +P+ +A+ L +
Sbjct: 395 -ALNGFTPLHIACKKNRIKVMELLVKYGASI---QAITESGLTPIHVAA-FMGHLNIVLL 449
Query: 157 LLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTC 216
LL GA + + G+TA LH A + V++ +R LL GA V A ++ T
Sbjct: 450 LLQNGASPDVTNIRGETA-LHMAARAGQVEV-----VRCLLRNGALVDARAREEQTPLH- 502
Query: 217 IIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPL 276
I LG+T ++ +LLL H A P + T + + + + +
Sbjct: 503 IASRLGKT----------------EIVQLLLQHMAHP-DAATTNGYTPLHISAREGQVDV 545
Query: 277 LRFLLESGAAYN 288
LLE+GAA++
Sbjct: 546 ASVLLEAGAAHS 557
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/185 (29%), Positives = 85/185 (45%), Gaps = 19/185 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P Y+A++E+ I V+ LLE A+ E L + G +A +LL +
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVH--HGADVNRRDRIHESS-----PLDLASEEPERL 151
P ALHIA ++ LL+ H ADV + ++ ++ PL +A+ +
Sbjct: 193 LP-----ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN-V 246
Query: 152 PCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGD 211
LL+ GA V+ ++G T L +AS G NT ++LLL+ G + A T+DG
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPL--HVASKRG----NTNMVKLLLDRGGQIDAKTRDGL 300
Query: 212 TVFTC 216
T C
Sbjct: 301 TPLHC 305
Score = 48.1 bits (113), Expect = 1e-05
Identities = 68/239 (28%), Positives = 108/239 (45%), Gaps = 40/239 (16%)
Query: 71 NALLKMAELGLTRAADVLLRHGANLNFEDPVTYY--TALHIAVLRNQPDMVELLVHHGAD 128
NAL A+ G LL G+++ D T TALHIA L Q ++V++LV GA+
Sbjct: 66 NALHLAAKEGHVGLVQELLGRGSSV---DSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 129 VNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIH 188
+N + + + +PL +A++E + ++ LL+ GA+ + A + G T L AL Q H
Sbjct: 123 INAQSQ-NGFTPLYMAAQE-NHIDVVKYLLENGANQSTATEDGFTPLAVALQ-----QGH 175
Query: 189 NTENIRLLLEGGADVK--------ATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFC- 239
N + + +LLE K A KD DT + LL D + M+NR
Sbjct: 176 N-QAVAILLENDTKGKVRLPALHIAARKD-DTKSAAL--LLQNDHNADVQSKMMVNRTTE 231
Query: 240 --------------FQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESG 284
V LLL GA + A +T + + S + + +++ LL+ G
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Score = 46.2 bits (108), Expect = 6e-05
Identities = 66/253 (26%), Positives = 106/253 (41%), Gaps = 27/253 (10%)
Query: 34 ESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGA 93
ES P ++A+ + V T LL R A F L ++ G T +LL G
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290
Query: 94 NLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPC 153
++ + T LH A +VELL+ GA + R + + SPL +A+ + + + C
Sbjct: 291 QIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAA-QGDHVEC 347
Query: 154 LQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTV 213
++ LL A V+ TA LH A ++ +LLL+ A+ A +G T
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTA-LHVAAHCGHYRV-----TKLLLDKRANPNARALNGFTP 401
Query: 214 FTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLH 273
A NR +V LL+ +GA + LT I + +F H
Sbjct: 402 L---------------HIACKKNR--IKVMELLVKYGAS-IQAITESGLTPIHVAAFMGH 443
Query: 274 FPLLRFLLESGAA 286
++ LL++GA+
Sbjct: 444 LNIVLLLLQNGAS 456
Score = 37.4 bits (85), Expect = 0.026
Identities = 48/182 (26%), Positives = 85/182 (46%), Gaps = 25/182 (13%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
++A++E + ++ ELL R + + + AL + G VL++ GAN+N +
Sbjct: 69 HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 128
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDL 160
+T L++A N D+V+ L+ +GA+ + +PL +A ++ + LL+
Sbjct: 129 -NGFTPLYMAAQENHIDVVKYLLENGANQSTATE-DGFTPLAVALQQGHN-QAVAILLE- 184
Query: 161 GADVNAADKHGKTAL--LHALASSDGVQIHNTENIRLLLEG--GADVKA------TTKDG 210
D GK L LH A D +T++ LLL+ ADV++ TT+ G
Sbjct: 185 ------NDTKGKVRLPALHIAARKD-----DTKSAALLLQNDHNADVQSKMMVNRTTESG 233
Query: 211 DT 212
T
Sbjct: 234 FT 235
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 61.6 bits (148), Expect = 1e-09
Identities = 69/237 (29%), Positives = 108/237 (45%), Gaps = 25/237 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P +VA++ + V LL+R+A + + L A + A +LL GA+ +
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH-A 624
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
YT LHIA +NQ + L+++GA+ N + +PL LAS+E + LL
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK-QGVTPLHLASQE-GHTDMVTLLL 682
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT--VFTC 216
D GA+++ + K G T+ LH A D V + + +L + GAD A TK G T + C
Sbjct: 683 DKGANIHMSTKSGLTS-LHLAAQEDKVNVAD-----ILTKHGADQDAHTKLGYTPLIVAC 736
Query: 217 -------IIFLL-------GETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAH 259
+ FLL +T G Q + + +LL HGA P+ A+
Sbjct: 737 HYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTAN 793
Score = 58.9 bits (141), Expect = 8e-09
Identities = 49/174 (28%), Positives = 89/174 (51%), Gaps = 9/174 (5%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++++++ + + LL A + + L ++ G T +LL GAN++
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLL 158
+ T+LH+A ++ ++ ++L HGAD + ++ + PL +A + + LL
Sbjct: 692 TK-SGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT-PLIVACHYGN-VKMVNFLL 748
Query: 159 DLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDT 212
GA+VNA K+G T L A Q +T I +LL+ GA ATT +G+T
Sbjct: 749 KQGANVNAKTKNGYTPLHQA------AQQGHTHIINVLLQHGAKPNATTANGNT 796
Score = 55.8 bits (133), Expect = 7e-08
Identities = 70/252 (27%), Positives = 113/252 (44%), Gaps = 31/252 (12%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P ++A++ + + LL+ KA AL A G R +LL AN N
Sbjct: 335 PLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNAR 394
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHES--SPLDLASEEPERLPCLQR 156
+ +T LHIA +N+ ++ELLV +GA + I ES +P+ +A+ L +
Sbjct: 395 -ALNGFTPLHIACKKNRIKVMELLVKYGASI---QAITESGLTPIHVAA-FMGHLNIVLL 449
Query: 157 LLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTC 216
LL GA + + G+TA LH A + V++ +R LL GA V A ++ T
Sbjct: 450 LLQNGASPDVTNIRGETA-LHMAARAGQVEV-----VRCLLRNGALVDARAREEQTPLH- 502
Query: 217 IIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPL 276
I LG+T ++ +LLL H A P + T + + + + +
Sbjct: 503 IASRLGKT----------------EIVQLLLQHMAHP-DAATTNGYTPLHISAREGQVDV 545
Query: 277 LRFLLESGAAYN 288
LLE+GAA++
Sbjct: 546 ASVLLEAGAAHS 557
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/185 (29%), Positives = 85/185 (45%), Gaps = 19/185 (10%)
Query: 39 PSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFE 98
P Y+A++E+ I V+ LLE A+ E L + G +A +LL +
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 99 DPVTYYTALHIAVLRNQPDMVELLVH--HGADVNRRDRIHESS-----PLDLASEEPERL 151
P ALHIA ++ LL+ H ADV + ++ ++ PL +A+ +
Sbjct: 193 LP-----ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGN-V 246
Query: 152 PCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGD 211
LL+ GA V+ ++G T L +AS G NT ++LLL+ G + A T+DG
Sbjct: 247 NVATLLLNRGAAVDFTARNGITPL--HVASKRG----NTNMVKLLLDRGGQIDAKTRDGL 300
Query: 212 TVFTC 216
T C
Sbjct: 301 TPLHC 305
Score = 48.1 bits (113), Expect = 1e-05
Identities = 68/239 (28%), Positives = 108/239 (45%), Gaps = 40/239 (16%)
Query: 71 NALLKMAELGLTRAADVLLRHGANLNFEDPVTYY--TALHIAVLRNQPDMVELLVHHGAD 128
NAL A+ G LL G+++ D T TALHIA L Q ++V++LV GA+
Sbjct: 66 NALHLAAKEGHVGLVQELLGRGSSV---DSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 129 VNRRDRIHESSPLDLASEEPERLPCLQRLLDLGADVNAADKHGKTALLHALASSDGVQIH 188
+N + + + +PL +A++E + ++ LL+ GA+ + A + G T L AL Q H
Sbjct: 123 INAQSQ-NGFTPLYMAAQE-NHIDVVKYLLENGANQSTATEDGFTPLAVALQ-----QGH 175
Query: 189 NTENIRLLLEGGADVK--------ATTKDGDTVFTCIIFLLGETVGGDKEEAQMINRFC- 239
N + + +LLE K A KD DT + LL D + M+NR
Sbjct: 176 N-QAVAILLENDTKGKVRLPALHIAARKD-DTKSAAL--LLQNDHNADVQSKMMVNRTTE 231
Query: 240 --------------FQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPLLRFLLESG 284
V LLL GA + A +T + + S + + +++ LL+ G
Sbjct: 232 SGFTPLHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Score = 46.2 bits (108), Expect = 6e-05
Identities = 66/253 (26%), Positives = 106/253 (41%), Gaps = 27/253 (10%)
Query: 34 ESLDRPSYVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGA 93
ES P ++A+ + V T LL R A F L ++ G T +LL G
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290
Query: 94 NLNFEDPVTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPC 153
++ + T LH A +VELL+ GA + R + + SPL +A+ + + + C
Sbjct: 291 QIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTK-NGLSPLHMAA-QGDHVEC 347
Query: 154 LQRLLDLGADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTV 213
++ LL A V+ TA LH A ++ +LLL+ A+ A +G T
Sbjct: 348 VKHLLQHKAPVDDVTLDYLTA-LHVAAHCGHYRV-----TKLLLDKRANPNARALNGFTP 401
Query: 214 FTCIIFLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLH 273
A NR +V LL+ +GA + LT I + +F H
Sbjct: 402 L---------------HIACKKNR--IKVMELLVKYGAS-IQAITESGLTPIHVAAFMGH 443
Query: 274 FPLLRFLLESGAA 286
++ LL++GA+
Sbjct: 444 LNIVLLLLQNGAS 456
Score = 37.4 bits (85), Expect = 0.026
Identities = 48/182 (26%), Positives = 85/182 (46%), Gaps = 25/182 (13%)
Query: 41 YVASEESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDP 100
++A++E + ++ ELL R + + + AL + G VL++ GAN+N +
Sbjct: 69 HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 128
Query: 101 VTYYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDL 160
+T L++A N D+V+ L+ +GA+ + +PL +A ++ + LL+
Sbjct: 129 -NGFTPLYMAAQENHIDVVKYLLENGANQSTATE-DGFTPLAVALQQGHN-QAVAILLE- 184
Query: 161 GADVNAADKHGKTAL--LHALASSDGVQIHNTENIRLLLEG--GADVKA------TTKDG 210
D GK L LH A D +T++ LLL+ ADV++ TT+ G
Sbjct: 185 ------NDTKGKVRLPALHIAARKD-----DTKSAALLLQNDHNADVQSKMMVNRTTESG 233
Query: 211 DT 212
T
Sbjct: 234 FT 235
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,602,395
Number of Sequences: 37866
Number of extensions: 753464
Number of successful extensions: 3624
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 1829
Number of HSP's gapped (non-prelim): 1064
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.