Search of human proteins with 14150169

Search of human proteins with 14150169

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo
sapiens]
         (282 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo sa...   580   e-166
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]                    75   8e-14
gi|120433593 diazepam binding inhibitor isoform 2 [Homo sapiens]       72   4e-13
gi|120433590 diazepam binding inhibitor isoform 3 [Homo sapiens]       72   4e-13
gi|10140853 diazepam binding inhibitor isoform 1 [Homo sapiens]        72   4e-13
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni...    70   2e-12
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit...    70   2e-12
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...    70   3e-12
gi|45643119 peroxisomal D3,D2-enoyl-CoA isomerase isoform 1 [Hom...    69   5e-12
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    69   5e-12
gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]    69   6e-12
gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]    69   6e-12
gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]    69   6e-12
gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]     69   6e-12
gi|239754056 PREDICTED: ankyrin repeat and death domain containi...    68   1e-11
gi|239748583 PREDICTED: ankyrin repeat and death domain containi...    68   1e-11
gi|239742602 PREDICTED: ankyrin repeat and death domain containi...    68   1e-11
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    68   1e-11
gi|118150656 ankyrin repeat domain 7 [Homo sapiens]                    67   2e-11
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                   67   2e-11
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     66   3e-11
gi|166235148 osteoclast stimulating factor 1 [Homo sapiens]            66   4e-11
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         65   5e-11
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    65   7e-11
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1...    65   7e-11
gi|118498337 HECT domain containing 1 [Homo sapiens]                   65   7e-11
gi|239757617 PREDICTED: similar to hCG1793014 [Homo sapiens]           65   9e-11
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun...    64   1e-10
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit...    64   1e-10
gi|239756067 PREDICTED: similar to Putative ankyrin repeat domai...    64   1e-10

>gi|14150169 acyl-coenzyme A binding domain containing 6 [Homo
           sapiens]
          Length = 282

 Score =  580 bits (1494), Expect = e-166
 Identities = 282/282 (100%), Positives = 282/282 (100%)

Query: 1   MASSFLPAGAITGDSGGELSSGDDSGEVEFPHSPEIEETSCLAELFEKAAAHLQGLIQVA 60
           MASSFLPAGAITGDSGGELSSGDDSGEVEFPHSPEIEETSCLAELFEKAAAHLQGLIQVA
Sbjct: 1   MASSFLPAGAITGDSGGELSSGDDSGEVEFPHSPEIEETSCLAELFEKAAAHLQGLIQVA 60

Query: 61  SREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKK 120
           SREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKK
Sbjct: 61  SREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKK 120

Query: 121 LDPGWNPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKS 180
           LDPGWNPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKS
Sbjct: 121 LDPGWNPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKS 180

Query: 181 KNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDI 240
           KNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDI
Sbjct: 181 KNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDI 240

Query: 241 VELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQRHTTGKA 282
           VELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQRHTTGKA
Sbjct: 241 VELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQRHTTGKA 282


>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
          Length = 1711

 Score = 74.7 bits (182), Expect = 8e-14
 Identities = 41/127 (32%), Positives = 63/127 (49%), Gaps = 11/127 (8%)

Query: 151  HEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTV 210
            H  T+ EE K++  YC + + +           DVN +D  G   LH AC RG  +++ +
Sbjct: 1426 HMATVSEEAKDVVLYCLQKDSE-----------DVNHRDNAGYTALHEACSRGWTDILNI 1474

Query: 211  LLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTV 270
            LL+H A++NC   +G   +H A   + L+ + LLL  GADPTL    G    ++    T+
Sbjct: 1475 LLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASSDTM 1534

Query: 271  SLVLQRH 277
               L  H
Sbjct: 1535 KRFLSDH 1541


>gi|120433593 diazepam binding inhibitor isoform 2 [Homo sapiens]
          Length = 88

 Score = 72.4 bits (176), Expect = 4e-13
 Identities = 34/76 (44%), Positives = 47/76 (61%)

Query: 46  FEKAAAHLQGLIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDS 105
           FEKAA  ++ L    S E++L++Y  YKQ  VG+ NT +P   DF GK KW+AW  L  +
Sbjct: 7   FEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGT 66

Query: 106 SPSQAMQEYIAVVKKL 121
           S   AM+ YI  V++L
Sbjct: 67  SKEDAMKAYINKVEEL 82


>gi|120433590 diazepam binding inhibitor isoform 3 [Homo sapiens]
          Length = 87

 Score = 72.4 bits (176), Expect = 4e-13
 Identities = 34/76 (44%), Positives = 47/76 (61%)

Query: 46  FEKAAAHLQGLIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDS 105
           FEKAA  ++ L    S E++L++Y  YKQ  VG+ NT +P   DF GK KW+AW  L  +
Sbjct: 6   FEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGT 65

Query: 106 SPSQAMQEYIAVVKKL 121
           S   AM+ YI  V++L
Sbjct: 66  SKEDAMKAYINKVEEL 81


>gi|10140853 diazepam binding inhibitor isoform 1 [Homo sapiens]
          Length = 104

 Score = 72.4 bits (176), Expect = 4e-13
 Identities = 34/76 (44%), Positives = 47/76 (61%)

Query: 46  FEKAAAHLQGLIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDS 105
           FEKAA  ++ L    S E++L++Y  YKQ  VG+ NT +P   DF GK KW+AW  L  +
Sbjct: 23  FEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGT 82

Query: 106 SPSQAMQEYIAVVKKL 121
           S   AM+ YI  V++L
Sbjct: 83  SKEDAMKAYINKVEEL 98


>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform b [Homo sapiens]
          Length = 998

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 36/111 (32%), Positives = 65/111 (58%), Gaps = 2/111 (1%)

Query: 155 IREEDKNIF-DYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQ 213
           +R ED  +F   C   + D + K + ++  D+N  + +G   LH AC   + ++V  L++
Sbjct: 54  VRFEDGAVFLAACSSGDTDEVRKLL-ARGADINTVNVDGLTALHQACIDENLDMVKFLVE 112

Query: 214 HRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEV 264
           +RA++N QDNEG T LH A++C +L+I E  +  GA   + + +G +P ++
Sbjct: 113 NRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDL 163



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 27/113 (23%), Positives = 56/113 (49%), Gaps = 8/113 (7%)

Query: 152 EETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVL 211
           E++ +EE++ +    R+         + S  ++   +   G   LH A  +G+ E++ +L
Sbjct: 185 EQSRKEEEQQMLQDARQ--------WLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLL 236

Query: 212 LQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEV 264
           +Q   ++N QD +G T LH A+     +   +L ++  D  +R++ G  P +V
Sbjct: 237 IQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289



 Score = 35.8 bits (81), Expect = 0.043
 Identities = 22/86 (25%), Positives = 39/86 (45%), Gaps = 2/86 (2%)

Query: 166 CRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEG 225
           C + N+D + K +     +VN +D EG   LH A   G+  +    + H A +   ++EG
Sbjct: 99  CIDENLDMV-KFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEG 157

Query: 226 QTALHYASACEFLD-IVELLLQSGAD 250
           +     A      D ++E + + G D
Sbjct: 158 EVPSDLAEEPAMKDLLLEQVKKQGID 183


>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform a [Homo sapiens]
          Length = 982

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 36/111 (32%), Positives = 65/111 (58%), Gaps = 2/111 (1%)

Query: 155 IREEDKNIF-DYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQ 213
           +R ED  +F   C   + D + K + ++  D+N  + +G   LH AC   + ++V  L++
Sbjct: 54  VRFEDGAVFLAACSSGDTDEVRKLL-ARGADINTVNVDGLTALHQACIDENLDMVKFLVE 112

Query: 214 HRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEV 264
           +RA++N QDNEG T LH A++C +L+I E  +  GA   + + +G +P ++
Sbjct: 113 NRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDL 163



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 27/113 (23%), Positives = 56/113 (49%), Gaps = 8/113 (7%)

Query: 152 EETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVL 211
           E++ +EE++ +    R+         + S  ++   +   G   LH A  +G+ E++ +L
Sbjct: 185 EQSRKEEEQQMLQDARQ--------WLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLL 236

Query: 212 LQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEV 264
           +Q   ++N QD +G T LH A+     +   +L ++  D  +R++ G  P +V
Sbjct: 237 IQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDV 289



 Score = 35.8 bits (81), Expect = 0.043
 Identities = 22/86 (25%), Positives = 39/86 (45%), Gaps = 2/86 (2%)

Query: 166 CRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEG 225
           C + N+D + K +     +VN +D EG   LH A   G+  +    + H A +   ++EG
Sbjct: 99  CIDENLDMV-KFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEG 157

Query: 226 QTALHYASACEFLD-IVELLLQSGAD 250
           +     A      D ++E + + G D
Sbjct: 158 EVPSDLAEEPAMKDLLLEQVKKQGID 183


>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
           isoform 1 [Homo sapiens]
          Length = 1298

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 69/277 (24%), Positives = 116/277 (41%), Gaps = 28/277 (10%)

Query: 8   AGAITGDSGGELSSGDDSGEVEFPHSPEIEETSCLAELFEKAAAHLQGLIQVASREQLLY 67
           A   TG + G   S DD  +    H PE  + +  A L        QG  +      L+ 
Sbjct: 667 ADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIA 726

Query: 68  LYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKKLDPGWNP 127
           L            ++ KP    F  KQ + +      +   +  +  + +V  +DP +  
Sbjct: 727 L------------DSEKPKKLRFHPKQLYFS------ARQGELQKVLLMLVDGIDPNFKM 768

Query: 128 QIPEKKGKEANTGFGGPV------ISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSK 181
           +   K+         G V      + +  + +T  E+ +       ENN     K +   
Sbjct: 769 EHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKA 828

Query: 182 NVDVNVKDEEGRALLHWACDRGHKELVTVLLQH-RADINCQDNEGQTALHYASACEFLDI 240
              V+ KD EG   LH A  +GH E+V  LL + + D+NCQD+ G T + +A+  + +D+
Sbjct: 829 GALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDL 888

Query: 241 VELLLQSGADPTLRDQDG--CLP-EEVTGCKTVSLVL 274
           V+LLL  G+D  +RD +   CL     +GC  ++ +L
Sbjct: 889 VKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 925



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 28/88 (31%), Positives = 47/88 (53%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           + K + SK  D+N++D E    LHWA   G  ++  +LL  + D++  +  G + LH A+
Sbjct: 888 LVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAA 947

Query: 234 ACEFLDIVELLLQSGADPTLRDQDGCLP 261
                D V L L   +D TL++++G  P
Sbjct: 948 RENRYDCVVLFLSRDSDVTLKNKEGETP 975



 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 27/84 (32%), Positives = 48/84 (57%)

Query: 167 RENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ 226
           ++ + + +   + +  +DVN +D+ G   + WA +  H +LV +LL   +DIN +DNE  
Sbjct: 848 KKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEEN 907

Query: 227 TALHYASACEFLDIVELLLQSGAD 250
             LH+A+    +DI E+LL +  D
Sbjct: 908 ICLHWAAFSGCVDIAEILLAAKCD 931


>gi|45643119 peroxisomal D3,D2-enoyl-CoA isomerase isoform 1 [Homo
           sapiens]
          Length = 364

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 39/104 (37%), Positives = 51/104 (49%), Gaps = 1/104 (0%)

Query: 46  FEKAAAHLQGLIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDS 105
           FE +   ++ L +    E  L LYA YKQ   G CN PKP  FD   K KW+AW ALG  
Sbjct: 13  FENSMNQVKLLKKDPGNEVKLKLYALYKQATEGPCNMPKPGVFDLINKAKWDAWNALGSL 72

Query: 106 SPSQAMQEYIAVVKKLDPGWNPQIPEKKGKE-ANTGFGGPVISS 148
               A Q Y+ +V  L P        + G +  +TGF   V++S
Sbjct: 73  PKEAARQNYVDLVSSLSPSLESSSQVEPGTDRKSTGFETLVVTS 116


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 34/85 (40%), Positives = 51/85 (60%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           + + +     +V  +D+ G   LH AC  GH E+V +LL+H AD N +DN   T LH A+
Sbjct: 73  VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132

Query: 234 ACEFLDIVELLLQSGADPTLRDQDG 258
               +D+  +LLQ GA+PT+R+ DG
Sbjct: 133 IKGKIDVCIVLLQHGAEPTIRNTDG 157



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 42/141 (29%), Positives = 70/141 (49%), Gaps = 7/141 (4%)

Query: 142 GGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRAL--LHWA 199
           GG    +    E +    + +F+ CR  +++ + + +  + V  N +D  GR    LH+A
Sbjct: 8   GGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKV--NSRDTAGRKSTPLHFA 65

Query: 200 CDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGC 259
              G K++V  LLQ+ A++  +D+ G   LH A +    ++V LLL+ GADP  RD    
Sbjct: 66  AGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNY 125

Query: 260 LP---EEVTGCKTVSLVLQRH 277
            P     + G   V +VL +H
Sbjct: 126 TPLHEAAIKGKIDVCIVLLQH 146



 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 35/88 (39%), Positives = 51/88 (57%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           + + +     DV+ KD+ G   LH AC  GH E+  +L++H A +N  D    T LH A+
Sbjct: 541 VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600

Query: 234 ACEFLDIVELLLQSGADPTLRDQDGCLP 261
           A    +I +LLLQ GADPT +++DG  P
Sbjct: 601 AKGKYEICKLLLQHGADPTKKNRDGNTP 628



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 31/85 (36%), Positives = 47/85 (55%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           I + +  K  ++N K +E    LH A ++ H ++V V+++H A +N  DN GQT+LH A+
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441

Query: 234 ACEFLDIVELLLQSGADPTLRDQDG 258
            C  L    LLL  G DP +    G
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQG 466



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 35/106 (33%), Positives = 57/106 (53%), Gaps = 1/106 (0%)

Query: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTA 228
           NN++ + + +     DVN +D+ G   LH A   GH ++  +L+++ A +N  D    T 
Sbjct: 690 NNLE-VAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTP 748

Query: 229 LHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVL 274
           LH A+      +  LLL  GADPTL++Q+G  P ++     VS +L
Sbjct: 749 LHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794



 Score = 55.8 bits (133), Expect = 4e-08
 Identities = 30/80 (37%), Positives = 44/80 (55%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           I + +     DV+ KD+     LH AC  GH E+  +L++H A +N  D    T LH A+
Sbjct: 226 IVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAA 285

Query: 234 ACEFLDIVELLLQSGADPTL 253
           +   +++  LLL  GADPTL
Sbjct: 286 SKNRVEVCSLLLSYGADPTL 305



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 30/101 (29%), Positives = 52/101 (51%), Gaps = 4/101 (3%)

Query: 157 EEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRAL--LHWACDRGHKELVTVLLQH 214
           E D+ + +  +  +++ + K    ++V  N +D EGR    LH+A       +V  LLQH
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTVQSV--NCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548

Query: 215 RADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRD 255
            AD++ +D  G   LH A +    ++ ELL++ GA   + D
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD 589



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 33/129 (25%), Positives = 56/129 (43%), Gaps = 4/129 (3%)

Query: 121 LDPGWNPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKS 180
           L  G  P I    G+ A      P   ++   E  ++E   + +  R  N + +   +  
Sbjct: 144 LQHGAEPTIRNTDGRTA-LDLADPSAKAVLTGEYKKDE---LLESARSGNEEKMMALLTP 199

Query: 181 KNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDI 240
            NV+ +  D      LH A      ++V +LLQH AD++ +D      LH A +    ++
Sbjct: 200 LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEV 259

Query: 241 VELLLQSGA 249
            ELL++ GA
Sbjct: 260 TELLVKHGA 268



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 16/149 (10%)

Query: 115 IAVVKKLDPGWNPQIPEKKGKEAN-----TGFGGPVISS--LYHEETIREEDKN----IF 163
           +A VKKL    N    + +G+ +       G+    ++   L H   +  +DK     + 
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717

Query: 164 DYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDN 223
           +     ++D     IK  N  VN  D+     LH A  +G  +L  +LL H AD   ++ 
Sbjct: 718 NAASYGHVDVAALLIKY-NACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776

Query: 224 EGQTALHYASACEFLDIVELLLQSGADPT 252
           EGQT L   SA    D V  LL +   P+
Sbjct: 777 EGQTPLDLVSA----DDVSALLTAAMPPS 801



 Score = 42.4 bits (98), Expect = 5e-04
 Identities = 29/74 (39%), Positives = 41/74 (55%), Gaps = 4/74 (5%)

Query: 190 EEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ--TALHYASACEFLDIVELLLQS 247
           E  R LL  A   G  E V  L   ++ +NC+D EG+  T LH+A+    + +VE LLQ 
Sbjct: 491 EADRQLLE-AAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548

Query: 248 GADPTLRDQDGCLP 261
           GAD   +D+ G +P
Sbjct: 549 GADVHAKDKGGLVP 562



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 4/97 (4%)

Query: 168 ENNIDHITKAIKSKNVDVNVKDE-EGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ 226
           + N D  T     K+ D +++D   G A L  A  +G    V  L     ++NC+D +G+
Sbjct: 620 KKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGR 678

Query: 227 --TALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
             T LH A+    L++ E LLQ GAD   +D+ G +P
Sbjct: 679 HSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP 715



 Score = 36.6 bits (83), Expect = 0.025
 Identities = 22/61 (36%), Positives = 36/61 (59%), Gaps = 3/61 (4%)

Query: 203 GHKELVTVLLQHRADINCQDNEGQ--TALHYASACEFLDIVELLLQSGADPTLRDQDGCL 260
           G++E +  LL    ++NC  ++G+  T LH A+    + IV+LLLQ GAD   +D+   +
Sbjct: 188 GNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLV 246

Query: 261 P 261
           P
Sbjct: 247 P 247



 Score = 33.9 bits (76), Expect = 0.16
 Identities = 18/49 (36%), Positives = 27/49 (55%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYA 232
           D N +D      LH A  +G  ++  VLLQH A+   ++ +G+TAL  A
Sbjct: 116 DPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164



 Score = 32.3 bits (72), Expect = 0.48
 Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           + + +      VN  D  G+  LH A   GH +   +LL +  D N    +G TAL   +
Sbjct: 415 VVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGN 474

Query: 234 ACEFLDIVELLLQSG 248
                + V+ LLQ G
Sbjct: 475 -----ENVQQLLQEG 484



 Score = 30.0 bits (66), Expect = 2.4
 Identities = 27/101 (26%), Positives = 46/101 (45%), Gaps = 4/101 (3%)

Query: 161 NIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGH---KELVTVLLQHRAD 217
           ++    RE ++  I K +  + V+         AL H A    +   K++  +LL+  A+
Sbjct: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETAL-HCAAASPYPKRKQICELLLRKGAN 392

Query: 218 INCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDG 258
           IN +  E  T LH AS     D+VE++++  A     D  G
Sbjct: 393 INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLG 433


>gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]
          Length = 1721

 Score = 68.6 bits (166), Expect = 6e-12
 Identities = 40/94 (42%), Positives = 48/94 (51%), Gaps = 11/94 (11%)

Query: 165  YCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNE 224
            YC EN I            DVN +D  G   LH AC RG   +V  LL++ AD+NC   +
Sbjct: 1447 YCLENKI-----------CDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQD 1495

Query: 225  GQTALHYASACEFLDIVELLLQSGADPTLRDQDG 258
            G   LH A   + L+IV LLL  GADPTL    G
Sbjct: 1496 GTRPLHDAVENDHLEIVRLLLSYGADPTLATYSG 1529



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 31/76 (40%), Positives = 42/76 (55%), Gaps = 1/76 (1%)

Query: 187  VKDEEGRALLHWACDRGHKELVTVLLQHR-ADINCQDNEGQTALHYASACEFLDIVELLL 245
            V    G  LL  A   G++E+V   L+++  D+N +DN G  ALH A A  +L+IV  LL
Sbjct: 1424 VNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLL 1483

Query: 246  QSGADPTLRDQDGCLP 261
            + GAD     QDG  P
Sbjct: 1484 EYGADVNCSAQDGTRP 1499



 Score = 32.7 bits (73), Expect = 0.37
 Identities = 17/57 (29%), Positives = 28/57 (49%)

Query: 173  HITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTAL 229
            +I + +     DVN   ++G   LH A +  H E+V +LL + AD       G+T +
Sbjct: 1477 NIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIM 1533


>gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]
          Length = 1755

 Score = 68.6 bits (166), Expect = 6e-12
 Identities = 40/94 (42%), Positives = 48/94 (51%), Gaps = 11/94 (11%)

Query: 165  YCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNE 224
            YC EN I            DVN +D  G   LH AC RG   +V  LL++ AD+NC   +
Sbjct: 1481 YCLENKI-----------CDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQD 1529

Query: 225  GQTALHYASACEFLDIVELLLQSGADPTLRDQDG 258
            G   LH A   + L+IV LLL  GADPTL    G
Sbjct: 1530 GTRPLHDAVENDHLEIVRLLLSYGADPTLATYSG 1563



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 31/76 (40%), Positives = 42/76 (55%), Gaps = 1/76 (1%)

Query: 187  VKDEEGRALLHWACDRGHKELVTVLLQHR-ADINCQDNEGQTALHYASACEFLDIVELLL 245
            V    G  LL  A   G++E+V   L+++  D+N +DN G  ALH A A  +L+IV  LL
Sbjct: 1458 VNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLL 1517

Query: 246  QSGADPTLRDQDGCLP 261
            + GAD     QDG  P
Sbjct: 1518 EYGADVNCSAQDGTRP 1533



 Score = 32.7 bits (73), Expect = 0.37
 Identities = 17/57 (29%), Positives = 28/57 (49%)

Query: 173  HITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTAL 229
            +I + +     DVN   ++G   LH A +  H E+V +LL + AD       G+T +
Sbjct: 1511 NIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIM 1567


>gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]
          Length = 1703

 Score = 68.6 bits (166), Expect = 6e-12
 Identities = 40/94 (42%), Positives = 48/94 (51%), Gaps = 11/94 (11%)

Query: 165  YCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNE 224
            YC EN I            DVN +D  G   LH AC RG   +V  LL++ AD+NC   +
Sbjct: 1429 YCLENKI-----------CDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQD 1477

Query: 225  GQTALHYASACEFLDIVELLLQSGADPTLRDQDG 258
            G   LH A   + L+IV LLL  GADPTL    G
Sbjct: 1478 GTRPLHDAVENDHLEIVRLLLSYGADPTLATYSG 1511



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 31/76 (40%), Positives = 42/76 (55%), Gaps = 1/76 (1%)

Query: 187  VKDEEGRALLHWACDRGHKELVTVLLQHR-ADINCQDNEGQTALHYASACEFLDIVELLL 245
            V    G  LL  A   G++E+V   L+++  D+N +DN G  ALH A A  +L+IV  LL
Sbjct: 1406 VNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLL 1465

Query: 246  QSGADPTLRDQDGCLP 261
            + GAD     QDG  P
Sbjct: 1466 EYGADVNCSAQDGTRP 1481



 Score = 32.7 bits (73), Expect = 0.37
 Identities = 17/57 (29%), Positives = 28/57 (49%)

Query: 173  HITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTAL 229
            +I + +     DVN   ++G   LH A +  H E+V +LL + AD       G+T +
Sbjct: 1459 NIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIM 1515


>gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]
          Length = 1721

 Score = 68.6 bits (166), Expect = 6e-12
 Identities = 40/94 (42%), Positives = 48/94 (51%), Gaps = 11/94 (11%)

Query: 165  YCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNE 224
            YC EN I            DVN +D  G   LH AC RG   +V  LL++ AD+NC   +
Sbjct: 1447 YCLENKI-----------CDVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQD 1495

Query: 225  GQTALHYASACEFLDIVELLLQSGADPTLRDQDG 258
            G   LH A   + L+IV LLL  GADPTL    G
Sbjct: 1496 GTRPLHDAVENDHLEIVRLLLSYGADPTLATYSG 1529



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 31/76 (40%), Positives = 42/76 (55%), Gaps = 1/76 (1%)

Query: 187  VKDEEGRALLHWACDRGHKELVTVLLQHR-ADINCQDNEGQTALHYASACEFLDIVELLL 245
            V    G  LL  A   G++E+V   L+++  D+N +DN G  ALH A A  +L+IV  LL
Sbjct: 1424 VNKNAGETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLL 1483

Query: 246  QSGADPTLRDQDGCLP 261
            + GAD     QDG  P
Sbjct: 1484 EYGADVNCSAQDGTRP 1499



 Score = 32.7 bits (73), Expect = 0.37
 Identities = 17/57 (29%), Positives = 28/57 (49%)

Query: 173  HITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTAL 229
            +I + +     DVN   ++G   LH A +  H E+V +LL + AD       G+T +
Sbjct: 1477 NIVRHLLEYGADVNCSAQDGTRPLHDAVENDHLEIVRLLLSYGADPTLATYSGRTIM 1533


>gi|239754056 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 524

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 39/132 (29%), Positives = 72/132 (54%), Gaps = 10/132 (7%)

Query: 128 QIPEKKGK-EANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVN 186
           +IP+++G  E +T   G         E +   +++  +  + NN+D + K  + K V++N
Sbjct: 45  RIPKREGLGEEDTAVAG--------HELLLPNERSFQNAAKSNNLDLMEKLFEKK-VNIN 95

Query: 187 VKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQ 246
           V +   R  LH+A  R H   V  LL+H+A ++  D  G T +H A+    L+++ +L++
Sbjct: 96  VVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVK 155

Query: 247 SGADPTLRDQDG 258
           +GAD   ++QDG
Sbjct: 156 AGADQRAKNQDG 167



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 25/79 (31%), Positives = 45/79 (56%)

Query: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTA 228
           NN   +  ++ S   D+++ +++ +  LH A DRG+ ELV  LL+   D+   D +G+TA
Sbjct: 356 NNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTA 415

Query: 229 LHYASACEFLDIVELLLQS 247
           L  AS      +V +L+++
Sbjct: 416 LAVASRSNHSLVVGMLIKA 434



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 31/95 (32%), Positives = 48/95 (50%)

Query: 180 SKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLD 239
           S+NVD++ K E   + LH      H  +V  LL  + DI+  + + QT LH A+    ++
Sbjct: 334 SENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVE 393

Query: 240 IVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVL 274
           +VE LL++G D    D+ G     V      SLV+
Sbjct: 394 LVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVV 428



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 19/59 (32%), Positives = 24/59 (40%)

Query: 192 GRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGAD 250
           G   LH A   GH   V VLL    DIN  +    ++L  A+      +V  LL    D
Sbjct: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVD 338



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 21/81 (25%), Positives = 34/81 (41%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVEL 243
           D+N  +E   + L  A   GH  LV  LL    D++ +    ++ LH       + +V  
Sbjct: 305 DINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNS 364

Query: 244 LLQSGADPTLRDQDGCLPEEV 264
           LL +  D  + +Q    P  V
Sbjct: 365 LLSAQHDIDILNQKQQTPLHV 385


>gi|239748583 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 524

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 39/132 (29%), Positives = 72/132 (54%), Gaps = 10/132 (7%)

Query: 128 QIPEKKGK-EANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVN 186
           +IP+++G  E +T   G         E +   +++  +  + NN+D + K  + K V++N
Sbjct: 45  RIPKREGLGEEDTAVAG--------HELLLPNERSFQNAAKSNNLDLMEKLFEKK-VNIN 95

Query: 187 VKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQ 246
           V +   R  LH+A  R H   V  LL+H+A ++  D  G T +H A+    L+++ +L++
Sbjct: 96  VVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVK 155

Query: 247 SGADPTLRDQDG 258
           +GAD   ++QDG
Sbjct: 156 AGADQRAKNQDG 167



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 25/79 (31%), Positives = 45/79 (56%)

Query: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTA 228
           NN   +  ++ S   D+++ +++ +  LH A DRG+ ELV  LL+   D+   D +G+TA
Sbjct: 356 NNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTA 415

Query: 229 LHYASACEFLDIVELLLQS 247
           L  AS      +V +L+++
Sbjct: 416 LAVASRSNHSLVVGMLIKA 434



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 31/95 (32%), Positives = 48/95 (50%)

Query: 180 SKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLD 239
           S+NVD++ K E   + LH      H  +V  LL  + DI+  + + QT LH A+    ++
Sbjct: 334 SENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVE 393

Query: 240 IVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVL 274
           +VE LL++G D    D+ G     V      SLV+
Sbjct: 394 LVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVV 428



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 19/59 (32%), Positives = 24/59 (40%)

Query: 192 GRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGAD 250
           G   LH A   GH   V VLL    DIN  +    ++L  A+      +V  LL    D
Sbjct: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVD 338



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 21/81 (25%), Positives = 34/81 (41%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVEL 243
           D+N  +E   + L  A   GH  LV  LL    D++ +    ++ LH       + +V  
Sbjct: 305 DINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNS 364

Query: 244 LLQSGADPTLRDQDGCLPEEV 264
           LL +  D  + +Q    P  V
Sbjct: 365 LLSAQHDIDILNQKQQTPLHV 385


>gi|239742602 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 607

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 39/132 (29%), Positives = 72/132 (54%), Gaps = 10/132 (7%)

Query: 128 QIPEKKGK-EANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVN 186
           +IP+++G  E +T   G         E +   +++  +  + NN+D + K  + K V++N
Sbjct: 45  RIPKREGLGEEDTAVAG--------HELLLPNERSFQNAAKSNNLDLMEKLFEKK-VNIN 95

Query: 187 VKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQ 246
           V +   R  LH+A  R H   V  LL+H+A ++  D  G T +H A+    L+++ +L++
Sbjct: 96  VVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVK 155

Query: 247 SGADPTLRDQDG 258
           +GAD   ++QDG
Sbjct: 156 AGADQRAKNQDG 167



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 25/79 (31%), Positives = 45/79 (56%)

Query: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTA 228
           NN   +  ++ S   D+++ +++ +  LH A DRG+ ELV  LL+   D+   D +G+TA
Sbjct: 356 NNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTA 415

Query: 229 LHYASACEFLDIVELLLQS 247
           L  AS      +V +L+++
Sbjct: 416 LAVASRSNHSLVVGMLIKA 434



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 31/95 (32%), Positives = 48/95 (50%)

Query: 180 SKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLD 239
           S+NVD++ K E   + LH      H  +V  LL  + DI+  + + QT LH A+    ++
Sbjct: 334 SENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVE 393

Query: 240 IVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVL 274
           +VE LL++G D    D+ G     V      SLV+
Sbjct: 394 LVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVV 428



 Score = 31.2 bits (69), Expect = 1.1
 Identities = 19/59 (32%), Positives = 24/59 (40%)

Query: 192 GRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGAD 250
           G   LH A   GH   V VLL    DIN  +    ++L  A+      +V  LL    D
Sbjct: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVD 338



 Score = 30.8 bits (68), Expect = 1.4
 Identities = 21/81 (25%), Positives = 34/81 (41%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVEL 243
           D+N  +E   + L  A   GH  LV  LL    D++ +    ++ LH       + +V  
Sbjct: 305 DINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNS 364

Query: 244 LLQSGADPTLRDQDGCLPEEV 264
           LL +  D  + +Q    P  V
Sbjct: 365 LLSAQHDIDILNQKQQTPLHV 385


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 42/117 (35%), Positives = 59/117 (50%), Gaps = 9/117 (7%)

Query: 151 HEETIREEDKNIFDYCRENNIDHITKAIKSKNV------DVNVKDEEGRALLHWACDRGH 204
           H   +   DKN   +    ++    KA+K   V       VNV D  GR  LH A   GH
Sbjct: 71  HSADVNARDKN---WQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127

Query: 205 KELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
            E+V +LL   A+IN  D + + ALH+A+    LD+V LL+  GA+ T +D+ G  P
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTP 184



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 25/71 (35%), Positives = 45/71 (63%)

Query: 180 SKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLD 239
           +K  ++N  D++ R  LHWA   GH ++V +L+ H A++ C+D +G T LH A++   ++
Sbjct: 136 AKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQIN 195

Query: 240 IVELLLQSGAD 250
           +V+ LL  G +
Sbjct: 196 VVKHLLNLGVE 206



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 29/94 (30%), Positives = 53/94 (56%), Gaps = 1/94 (1%)

Query: 173 HITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYA 232
           ++ K + +  V+++  +  G   LH AC  G   +V  L+ + A++N  +N G T LH+A
Sbjct: 195 NVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFA 254

Query: 233 SACEFLDI-VELLLQSGADPTLRDQDGCLPEEVT 265
           +A     + +ELL+ +GAD  ++ +DG  P  +T
Sbjct: 255 AASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 30/84 (35%), Positives = 43/84 (51%)

Query: 181 KNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDI 240
           K  DVN  D E R  LH A   G  E++ +L+   A +N +DN   T LH A A    + 
Sbjct: 5   KTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEA 64

Query: 241 VELLLQSGADPTLRDQDGCLPEEV 264
           V++L++  AD   RD++   P  V
Sbjct: 65  VQVLIKHSADVNARDKNWQTPLHV 88



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 33/111 (29%), Positives = 52/111 (46%), Gaps = 28/111 (25%)

Query: 176 KAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASAC 235
           K ++S   D + KD+ GR  LH+A    H   +  L+   A++N  D+ G+TALHYA+A 
Sbjct: 397 KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAAS 456

Query: 236 ----------------------------EFLDIVELLLQSGADPTLRDQDG 258
                                       E    +E LLQ+ A+P++RD++G
Sbjct: 457 DMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEG 507



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 1/74 (1%)

Query: 185 VNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELL 244
           V+ +D++GR  L  A    H E + +LL+H A +N  DN G+TAL  A+       V++L
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866

Query: 245 LQSG-ADPTLRDQD 257
           + S  AD T++D+D
Sbjct: 867 VNSAQADLTVKDKD 880



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 32/95 (33%), Positives = 48/95 (50%), Gaps = 4/95 (4%)

Query: 170 NIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTAL 229
           +ID ++  ++ K  +V+  D  G   LH     GH+E V +LL+    I C+D+ G+T L
Sbjct: 657 HIDAVSLLLE-KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPL 715

Query: 230 HYASACEFLDIVELLLQ---SGADPTLRDQDGCLP 261
           HYA+A      +  LLQ   S  D   +D  G  P
Sbjct: 716 HYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 26/83 (31%), Positives = 43/83 (51%)

Query: 176 KAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASAC 235
           + + S   +++  D+ GR  LH A   G+ E + +L    AD + +D  G+T LHYA+A 
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAAN 423

Query: 236 EFLDIVELLLQSGADPTLRDQDG 258
                +E L+ +GA+    D  G
Sbjct: 424 CHFHCIETLVTTGANVNETDDWG 446



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 25/74 (33%), Positives = 39/74 (52%)

Query: 185 VNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELL 244
           VN KD      LH A     +E V VL++H AD+N +D   QT LH A+A + +   E++
Sbjct: 42  VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101

Query: 245 LQSGADPTLRDQDG 258
           +   +   + D+ G
Sbjct: 102 IPLLSSVNVSDRGG 115



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 22/71 (30%), Positives = 37/71 (52%)

Query: 180 SKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLD 239
           +   DVN++ ++G++ LH     G       L+Q+  +I+C D +G T LH A+      
Sbjct: 269 NNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL 328

Query: 240 IVELLLQSGAD 250
           ++  L  SGAD
Sbjct: 329 LINTLRTSGAD 339



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 3/78 (3%)

Query: 172 DHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQ---HRADINCQDNEGQTA 228
           +   + +  + V +  KD  GR  LH+A  RGH   ++ LLQ      D   +DN+G T 
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750

Query: 229 LHYASACEFLDIVELLLQ 246
           LH+A      + +E+LL+
Sbjct: 751 LHWACYNGNENCIEVLLE 768



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 22/60 (36%), Positives = 34/60 (56%)

Query: 196 LHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRD 255
           LH A   GH + + VLLQ   D++ +D +G+TAL  A+     + VE L+  GA   ++D
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 26/97 (26%), Positives = 45/97 (46%), Gaps = 1/97 (1%)

Query: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKEL-VTVLLQHRADINCQDNEGQT 227
           N  D +   +     +VN  +  G   LH+A    H  L + +L+ + AD+N Q  +G++
Sbjct: 224 NGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKS 283

Query: 228 ALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEV 264
            LH  +        + L+Q+G +    D+DG  P  V
Sbjct: 284 PLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHV 320



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 25/77 (32%), Positives = 40/77 (51%)

Query: 185 VNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELL 244
           V+VKD +G+  L  A   GH + V++LL+  A+++  D  G TALH        + V++L
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697

Query: 245 LQSGADPTLRDQDGCLP 261
           L+       +D  G  P
Sbjct: 698 LEQEVSILCKDSRGRTP 714



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 29/109 (26%), Positives = 45/109 (41%), Gaps = 34/109 (31%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQ---------------HRADIN--------- 219
           D   KD +G   LHWAC  G++  + VLL+               H A IN         
Sbjct: 739 DCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLL 798

Query: 220 ----------CQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDG 258
                     C+D++G+T L  A+  + ++ ++LLL+  A     D  G
Sbjct: 799 LGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSG 847



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 23/75 (30%), Positives = 41/75 (54%), Gaps = 2/75 (2%)

Query: 186 NVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQT--ALHYASACEFLDIVEL 243
           +++D+EG   +H+A   GH++ + +LL+       + + G T   LH A+       +E+
Sbjct: 501 SIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEV 560

Query: 244 LLQSGADPTLRDQDG 258
           LLQS  D  +RD+ G
Sbjct: 561 LLQSLVDLDIRDEKG 575



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 23/66 (34%), Positives = 34/66 (51%)

Query: 196 LHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRD 255
           LH A    H +    LL    +I+  D  G+T LH A+A   ++ ++LL  SGAD   +D
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410

Query: 256 QDGCLP 261
           + G  P
Sbjct: 411 KCGRTP 416



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 25/74 (33%), Positives = 38/74 (51%), Gaps = 1/74 (1%)

Query: 183 VDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDN-EGQTALHYASACEFLDIV 241
           VD++++DE+GR  L  A  +GH E V  L+   A I  +DN   +T LH +        +
Sbjct: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625

Query: 242 ELLLQSGADPTLRD 255
            LLL+   +P   D
Sbjct: 626 RLLLEIADNPEAVD 639



 Score = 35.0 bits (79), Expect = 0.074
 Identities = 29/110 (26%), Positives = 45/110 (40%), Gaps = 28/110 (25%)

Query: 165 YCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWAC----DRGHKEL------------- 207
           Y   N   H  + + +   +VN  D+ GR  LH+A     DR    L             
Sbjct: 419 YAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERA 478

Query: 208 -----------VTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQ 246
                      +  LLQ+ A+ + +D EG  ++HYA+A      +ELLL+
Sbjct: 479 RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 17/46 (36%), Positives = 27/46 (58%)

Query: 210 VLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRD 255
           +L+    D+N  D+E +T LH A+     +I+ELL+ SGA    +D
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKD 46



 Score = 33.9 bits (76), Expect = 0.16
 Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 3/53 (5%)

Query: 178 IKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLL---QHRADINCQDNEGQT 227
           + S   D+ VKD++    LH AC +GH++   ++L   Q  + IN ++N  QT
Sbjct: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNNALQT 919


>gi|118150656 ankyrin repeat domain 7 [Homo sapiens]
          Length = 254

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 35/102 (34%), Positives = 59/102 (57%), Gaps = 1/102 (0%)

Query: 155 IREED-KNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQ 213
           +RE+D K +       ++  + + ++ K  DVN++D++ R  LH AC  GH ++V  L++
Sbjct: 21  LREKDLKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACANGHTDVVLFLIE 80

Query: 214 HRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRD 255
            +  IN +D+E ++ L  A  C+  D   +LL  GADP LRD
Sbjct: 81  QQCKINVRDSENKSPLIKAVQCQNEDCATILLNFGADPDLRD 122



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 24/67 (35%), Positives = 38/67 (56%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVEL 243
           D+  K+++G   L  A    + ++V  LL+  AD+N  DN  +TAL  A + E   +V+L
Sbjct: 150 DLEAKNKDGYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILAVSGEPPCLVKL 209

Query: 244 LLQSGAD 250
           LLQ G +
Sbjct: 210 LLQQGVE 216



 Score = 33.5 bits (75), Expect = 0.22
 Identities = 21/83 (25%), Positives = 41/83 (49%)

Query: 179 KSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFL 238
           ++++   N+++++ + L   A     K+L   L   + D+N QD + +T LH A A    
Sbjct: 13  ETRSQGYNLREKDLKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACANGHT 72

Query: 239 DIVELLLQSGADPTLRDQDGCLP 261
           D+V  L++      +RD +   P
Sbjct: 73  DVVLFLIEQQCKINVRDSENKSP 95


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 3/127 (2%)

Query: 135 KEANTGFGGPVISSLYHEETIREEDKN---IFDYCRENNIDHITKAIKSKNVDVNVKDEE 191
           + ++ G GG      Y +      D++   I       N+  + + +  +   +N +D+ 
Sbjct: 20  QRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKM 79

Query: 192 GRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADP 251
            R  LH AC  GH E+VT+L+  +  +N  DNE +TAL  A  C+      +LL+ GADP
Sbjct: 80  NRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADP 139

Query: 252 TLRDQDG 258
            L D  G
Sbjct: 140 NLADVHG 146



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 29/93 (31%), Positives = 43/93 (46%)

Query: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTA 228
           N    +   +  +   +NV D E R  L  A     ++  T+LL+H AD N  D  G TA
Sbjct: 90  NGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTA 149

Query: 229 LHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
           LHYA   E + +   LL   A+   +++D   P
Sbjct: 150 LHYAVYNEDISVATKLLLYDANIEAKNKDDLTP 182


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 36/84 (42%), Positives = 48/84 (57%), Gaps = 1/84 (1%)

Query: 166 CRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEG 225
           C++ +   + K +   N   N KD  G   L +AC  GH ELV +LLQH A IN  +N+G
Sbjct: 785 CQQGHFQ-VVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKG 843

Query: 226 QTALHYASACEFLDIVELLLQSGA 249
            TALH A   + + +VELLL  GA
Sbjct: 844 NTALHEAVIEKHVFVVELLLLHGA 867



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 25/66 (37%), Positives = 34/66 (51%)

Query: 180 SKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLD 239
           SK   VN  D  G   LH AC +G++ +  +LL ++A    QDN G T LH A      D
Sbjct: 484 SKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHED 543

Query: 240 IVELLL 245
            V+ L+
Sbjct: 544 CVKALV 549



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 25/84 (29%), Positives = 42/84 (50%)

Query: 178 IKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEF 237
           + +  + VNV  ++G + LH A   G  +L+ +LL+H A+   ++ +    LH A     
Sbjct: 730 VPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGH 789

Query: 238 LDIVELLLQSGADPTLRDQDGCLP 261
             +V+ LL S A P  +D  G  P
Sbjct: 790 FQVVKCLLDSNAKPNKKDLSGNTP 813



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 6/104 (5%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRAD---INCQDNEGQTALH 230
           +T  +        V+D  G   LH AC  GH++ V  L+ +  +   ++  + +G T LH
Sbjct: 511 VTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLH 570

Query: 231 YASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVL 274
            A+   +  ++E LLQ+GA   ++++   L E    C   S +L
Sbjct: 571 IAARWGYQGVIETLLQNGASTEIQNR---LKETPLKCALNSKIL 611



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 25/63 (39%), Positives = 33/63 (52%)

Query: 196 LHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRD 255
           LH AC +GH ++V  LL   A  N +D  G T L YA +    ++V LLLQ GA     +
Sbjct: 781 LHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN 840

Query: 256 QDG 258
             G
Sbjct: 841 NKG 843



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 23/74 (31%), Positives = 34/74 (45%)

Query: 188 KDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQS 247
           +D+ G   LH A   G   L+ +L+   A +N  D  G T LH A    +  +  LLL  
Sbjct: 459 RDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHY 518

Query: 248 GADPTLRDQDGCLP 261
            A   ++D +G  P
Sbjct: 519 KASAEVQDNNGNTP 532



 Score = 29.3 bits (64), Expect = 4.1
 Identities = 16/58 (27%), Positives = 31/58 (53%)

Query: 185 VNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVE 242
           +++ +E+G   LH A   G++ ++  LLQ+ A    Q+   +T L  A   + L ++E
Sbjct: 558 LDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVME 615


>gi|166235148 osteoclast stimulating factor 1 [Homo sapiens]
          Length = 214

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 44/137 (32%), Positives = 71/137 (51%), Gaps = 3/137 (2%)

Query: 145 VISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGH 204
           +I S Y  E     D  + +  +  N+  + + + ++ V VN  D+ G   L+WAC  GH
Sbjct: 60  LIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNR-VGVNGLDKAGSTALYWACHGGH 118

Query: 205 KELVTVLL-QHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLP-E 262
           K++V +L  Q   ++N Q+  G TALH A+   + DIV+LLL  GA   LR+ +  L  +
Sbjct: 119 KDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFD 178

Query: 263 EVTGCKTVSLVLQRHTT 279
             T     SL+ ++  T
Sbjct: 179 MATNAACASLLKKKQGT 195



 Score = 32.0 bits (71), Expect = 0.63
 Identities = 21/98 (21%), Positives = 46/98 (46%)

Query: 166 CRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEG 225
           C   + D +       N+++N +++ G   LH A  +G+ ++V +LL   A  + ++ E 
Sbjct: 114 CHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEK 173

Query: 226 QTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEE 263
           + A   A+      +++    + A  TL + +  L +E
Sbjct: 174 KLAFDMATNAACASLLKKKQGTDAVRTLSNAEDYLDDE 211


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 36/108 (33%), Positives = 59/108 (54%), Gaps = 3/108 (2%)

Query: 156 REEDKNIFDYCRENNIDHITKAIK--SKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQ 213
           ++ D N   Y R     H+ KA+      VD+N+ ++ G   LH A   GH E+V+ LLQ
Sbjct: 37  KKSDANA-SYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQ 95

Query: 214 HRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
             A+++    +G TALH AS     ++V++L+ +GA+   + Q+G  P
Sbjct: 96  REANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTP 143



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 34/114 (29%), Positives = 58/114 (50%), Gaps = 7/114 (6%)

Query: 167 RENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ 226
           ++N +D I   +     D N    +G A +H A   GH ++V++LL   A++N  +  G 
Sbjct: 640 KKNQMD-IATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698

Query: 227 TALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGC-----KTVSLVLQ 275
           T LH A+  + +++ E+L+  GA    + + G  P  V GC     K V+ +LQ
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV-GCHYGNIKIVNFLLQ 751



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 24/79 (30%), Positives = 42/79 (53%)

Query: 173 HITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYA 232
           ++ + + ++   V+ + + G   LH  C  G+ ++V  LLQH A +N +   G T LH A
Sbjct: 711 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 770

Query: 233 SACEFLDIVELLLQSGADP 251
           +      I+ +LLQ+ A P
Sbjct: 771 AQQGHTHIINVLLQNNASP 789



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 27/100 (27%), Positives = 47/100 (47%), Gaps = 1/100 (1%)

Query: 166 CRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEG 225
           C++N I  + + +      +    E G   +H A   GH  +V+ L+ H A  N  +  G
Sbjct: 408 CKKNRIK-VMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466

Query: 226 QTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVT 265
           +TALH A+     ++V  L+Q GA    + +D   P  ++
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 27/89 (30%), Positives = 38/89 (42%)

Query: 173 HITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYA 232
           +I   +       N  +  G   LH A   G  E+V  L+Q  A +  +  + QT LH +
Sbjct: 447 NIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506

Query: 233 SACEFLDIVELLLQSGADPTLRDQDGCLP 261
           +     DIV+ LLQ GA P      G  P
Sbjct: 507 ARLGKADIVQQLLQQGASPNAATTSGYTP 535



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 26/91 (28%), Positives = 40/91 (43%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           I + +  +    N     G   LH +   GH+++   LL H A ++    +G T LH A+
Sbjct: 514 IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA 573

Query: 234 ACEFLDIVELLLQSGADPTLRDQDGCLPEEV 264
               L++  LLLQ  A P    + G  P  V
Sbjct: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 26/97 (26%), Positives = 46/97 (47%), Gaps = 1/97 (1%)

Query: 172 DHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHY 231
           + + + +  +   +  K + G + LH A    H   V +LLQH   ++   N+  TALH 
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373

Query: 232 ASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCK 268
           A+ C    + ++LL   A+P  +  +G  P  +  CK
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI-ACK 409



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 25/85 (29%), Positives = 40/85 (47%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           + K +  K  + N K   G   LH AC +   +++ +LL+H A I      G T +H A+
Sbjct: 382 VAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAA 441

Query: 234 ACEFLDIVELLLQSGADPTLRDQDG 258
               ++IV  L+  GA P   +  G
Sbjct: 442 FMGHVNIVSQLMHHGASPNTTNVRG 466



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 22/74 (29%), Positives = 39/74 (52%)

Query: 173 HITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYA 232
           ++ K +  +   ++ K  +G   LH     GH+++V +LL   A I  +   G + LH A
Sbjct: 282 NMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMA 341

Query: 233 SACEFLDIVELLLQ 246
           +  + L+ V+LLLQ
Sbjct: 342 TQGDHLNCVQLLLQ 355



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 1/79 (1%)

Query: 166 CRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEG 225
           C   NI  I   +   +  VN K + G   LH A  +GH  ++ VLLQ+ A  N     G
Sbjct: 738 CHYGNIK-IVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNG 796

Query: 226 QTALHYASACEFLDIVELL 244
            TAL  A    ++ +V+ L
Sbjct: 797 NTALGIARRLGYISVVDTL 815



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 25/95 (26%), Positives = 44/95 (46%), Gaps = 1/95 (1%)

Query: 167 RENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ 226
           +E ++D ++  +  +N +VN+ ++ G   LH A       +  VL+   A ++ Q   G 
Sbjct: 673 QEGHVDMVSLLL-GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY 731

Query: 227 TALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
           T LH       + IV  LLQ  A    + ++G  P
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 22/72 (30%), Positives = 37/72 (51%)

Query: 190 EEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGA 249
           + G   LH A  +   ++ T LL++ AD N    +G  ++H A+    +D+V LLL   A
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688

Query: 250 DPTLRDQDGCLP 261
           +  L ++ G  P
Sbjct: 689 NVNLSNKSGLTP 700



 Score = 41.6 bits (96), Expect = 8e-04
 Identities = 29/95 (30%), Positives = 44/95 (46%), Gaps = 2/95 (2%)

Query: 172 DHIT--KAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTAL 229
           DH+   + +   NV V+    +    LH A   GH ++  VLL  +A+ N +   G T L
Sbjct: 345 DHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPL 404

Query: 230 HYASACEFLDIVELLLQSGADPTLRDQDGCLPEEV 264
           H A     + ++ELLL+ GA      + G  P  V
Sbjct: 405 HIACKKNRIKVMELLLKHGASIQAVTESGLTPIHV 439



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 27/102 (26%), Positives = 44/102 (43%), Gaps = 1/102 (0%)

Query: 167 RENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ 226
           RE + D +   +      +++  ++G   LH A   G  E+  +LLQ  A  +     G 
Sbjct: 541 REGHED-VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL 599

Query: 227 TALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCK 268
           T LH A+  +   +  LLL  GA P    ++G  P  +   K
Sbjct: 600 TPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKK 641



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 27/113 (23%), Positives = 47/113 (41%), Gaps = 4/113 (3%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           + + +      V  K ++ +  LH +   G  ++V  LLQ  A  N     G T LH ++
Sbjct: 481 VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA 540

Query: 234 ACEFLDIVELLLQSGADPTLRDQDGCLPEEVTG----CKTVSLVLQRHTTGKA 282
                D+   LL  GA  ++  + G  P  V       +  +L+LQ+  +  A
Sbjct: 541 REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 24/78 (30%), Positives = 38/78 (48%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVEL 243
           + +V+ + G   LH A   G+  + T+LL   A ++       T LH AS     ++V+L
Sbjct: 227 NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286

Query: 244 LLQSGADPTLRDQDGCLP 261
           LL  GA    + +DG  P
Sbjct: 287 LLDRGAKIDAKTRDGLTP 304



 Score = 37.7 bits (86), Expect = 0.011
 Identities = 21/66 (31%), Positives = 33/66 (50%)

Query: 196 LHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRD 255
           LH A  RG+  +V +LL   A I+ +  +G T LH  +      +VE+LL   A    + 
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331

Query: 256 QDGCLP 261
           ++G  P
Sbjct: 332 KNGLSP 337



 Score = 34.7 bits (78), Expect = 0.097
 Identities = 21/85 (24%), Positives = 36/85 (42%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           +   +  K+   +   + G   LH A    ++++  +LL   A  +     G T LH A+
Sbjct: 580 VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639

Query: 234 ACEFLDIVELLLQSGADPTLRDQDG 258
               +DI   LL+ GAD     + G
Sbjct: 640 KKNQMDIATTLLEYGADANAVTRQG 664



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 25/102 (24%), Positives = 43/102 (42%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           + K + +   +VN + + G   L+ A    H E+V  LL + A  +    +G T L  A 
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVAL 181

Query: 234 ACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQ 275
                 +V LLL++     +R     +       K  +L+LQ
Sbjct: 182 QQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 35/92 (38%), Positives = 55/92 (59%), Gaps = 4/92 (4%)

Query: 167 RENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ 226
           R++ ++H+ +       +V+ +D+ G   LH AC  GH E+V++LL   AD N +DN   
Sbjct: 228 RKDVVEHLLQM----GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNY 283

Query: 227 TALHYASACEFLDIVELLLQSGADPTLRDQDG 258
           T LH A+    +D+  +LLQ GADP +R+ DG
Sbjct: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315



 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 16/146 (10%)

Query: 137 ANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGR--A 194
           A  G G P +S    E         + + CR  ++  + + + + NV  N KD  GR  +
Sbjct: 170 AGPGTGVPAVSGALRE---------LLEACRNGDVSRVKRLVDAANV--NAKDMAGRKSS 218

Query: 195 LLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLR 254
            LH+A   G K++V  LLQ  A+++ +D+ G   LH A +    ++V LLL  GADP  R
Sbjct: 219 PLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR 278

Query: 255 DQDGCLP---EEVTGCKTVSLVLQRH 277
           D     P     + G   V +VL +H
Sbjct: 279 DNWNYTPLHEAAIKGKIDVCIVLLQH 304



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 34/78 (43%), Positives = 48/78 (61%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVEL 243
           DV+ KD+ G   LH AC  GH E+  +L++H A +N  D    T LH A+A    +I +L
Sbjct: 709 DVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKL 768

Query: 244 LLQSGADPTLRDQDGCLP 261
           LL+ GADPT +++DG  P
Sbjct: 769 LLKHGADPTKKNRDGNTP 786



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 1/105 (0%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           +T+ +  K  +VN K+++    LH A +R H +++ VL +H A +N  D  GQTALH A+
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599

Query: 234 ACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQRHT 278
               L    LLL  G+DP++    G    ++ G + V  +L   T
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQM-GNEAVQQILSEST 643



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 32/80 (40%), Positives = 45/80 (56%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           I + +     DV+ KD+ G   LH AC  GH E+  +LL+H A +N  D    T LH A+
Sbjct: 384 IVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAA 443

Query: 234 ACEFLDIVELLLQSGADPTL 253
           +   +++  LLL  GADPTL
Sbjct: 444 SKNRVEVCSLLLSHGADPTL 463



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 31/106 (29%), Positives = 55/106 (51%), Gaps = 1/106 (0%)

Query: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTA 228
           NN++ + + +     DVN +D+ G   LH A   GH ++  +L+++   +N  D    T 
Sbjct: 848 NNLE-VAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTP 906

Query: 229 LHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVL 274
           LH A+      +  LLL  GADPT+++Q+G  P ++     +  +L
Sbjct: 907 LHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952



 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 36/129 (27%), Positives = 57/129 (44%), Gaps = 4/129 (3%)

Query: 121 LDPGWNPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKS 180
           L  G +P I    GK A      P   ++   E  ++E   + +  R  N + +   +  
Sbjct: 302 LQHGADPNIRNTDGKSA-LDLADPSAKAVLTGEYKKDE---LLEAARSGNEEKLMALLTP 357

Query: 181 KNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDI 240
            NV+ +  D      LH A       +V +LLQH AD++ +D  G   LH A +    ++
Sbjct: 358 LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEV 417

Query: 241 VELLLQSGA 249
            ELLL+ GA
Sbjct: 418 TELLLKHGA 426



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 38/140 (27%), Positives = 64/140 (45%), Gaps = 8/140 (5%)

Query: 121 LDPGWNPQIPEKKGKEANTGFGGPVISSLYHEET---IREEDKNIFDYCRENNIDHITKA 177
           L  G +P I   +G  A    G   +  +  E T     + D  + +  +  +++ + + 
Sbjct: 611 LSYGSDPSIISLQGFTA-AQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQL 669

Query: 178 IKSKNVDVNVKDEEGR--ALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASAC 235
             S+NV  N +D EGR    LH+A       +V  LL H AD++ +D  G   LH A + 
Sbjct: 670 CSSQNV--NCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSY 727

Query: 236 EFLDIVELLLQSGADPTLRD 255
              ++ ELL++ GA   + D
Sbjct: 728 GHYEVAELLVRHGASVNVAD 747



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 29/86 (33%), Positives = 45/86 (52%), Gaps = 5/86 (5%)

Query: 178 IKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ--TALHYASAC 235
           I S++  +   D + R L   A   G  E V  L   + ++NC+D EG+  T LH+A+  
Sbjct: 638 ILSESTPIRTSDVDYRLLE--ASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGY 694

Query: 236 EFLDIVELLLQSGADPTLRDQDGCLP 261
             + +VE LL  GAD   +D+ G +P
Sbjct: 695 NRVSVVEYLLHHGADVHAKDKGGLVP 720



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 32/97 (32%), Positives = 48/97 (49%), Gaps = 4/97 (4%)

Query: 168 ENNIDHITKAIKSKNVDVNVKDE-EGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQ 226
           + N D  T     K  D +++D   G A L  A  +G    V  L     +INC+D +G+
Sbjct: 778 KKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE-NINCRDTQGR 836

Query: 227 --TALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
             T LH A+    L++ E LL+ GAD   +D+ G +P
Sbjct: 837 NSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIP 873



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 30/103 (29%), Positives = 48/103 (46%), Gaps = 4/103 (3%)

Query: 159 DKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADI 218
           D NI +   ++ +D    + K+       KDE    LL  A     ++L+ +L     + 
Sbjct: 307 DPNIRNTDGKSALDLADPSAKAVLTGEYKKDE----LLEAARSGNEEKLMALLTPLNVNC 362

Query: 219 NCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
           +  D    T LH A+    + IV+LLLQ GAD   +D+ G +P
Sbjct: 363 HASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVP 405



 Score = 37.0 bits (84), Expect = 0.019
 Identities = 19/59 (32%), Positives = 31/59 (52%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYA 232
           +   +  +  D N +D      LH A  +G  ++  VLLQH AD N ++ +G++AL  A
Sbjct: 264 VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322


>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
           [Homo sapiens]
          Length = 567

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 33/96 (34%), Positives = 59/96 (61%), Gaps = 1/96 (1%)

Query: 169 NNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTA 228
           N+ + +   +K+K V  ++ +E+G   LH  C    +E+V +LL H A++N +DNE  T 
Sbjct: 79  NDAEEVRYFLKNK-VSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTP 137

Query: 229 LHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEV 264
           LH A+ C  +++V++L+Q GAD    + DG +P ++
Sbjct: 138 LHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL 173



 Score = 45.1 bits (105), Expect = 7e-05
 Identities = 26/86 (30%), Positives = 40/86 (46%)

Query: 157 EEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRA 216
           E+       C  +N + I K + S   +VN KD E    LH A   GH  LV +L+Q+ A
Sbjct: 99  EDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158

Query: 217 DINCQDNEGQTALHYASACEFLDIVE 242
           D+   +++G            LD++E
Sbjct: 159 DLLAVNSDGNMPYDLCEDEPTLDVIE 184



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 22/71 (30%), Positives = 36/71 (50%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVEL 243
           D++  D +G  LLH A   G+     +LL H   ++ +D +G   LH A+    + + EL
Sbjct: 221 DLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAEL 280

Query: 244 LLQSGADPTLR 254
           L+  GA  + R
Sbjct: 281 LVSHGASLSAR 291



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 2/88 (2%)

Query: 187 VKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQ 246
           V  E   ALL  A  R   E V   L+++   +  + +G TALH      F +IV+LLL 
Sbjct: 64  VSFEASVALLE-ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLS 122

Query: 247 SGADPTLRDQDGCLP-EEVTGCKTVSLV 273
            GA+   +D +   P      C  ++LV
Sbjct: 123 HGANVNAKDNELWTPLHAAATCGHINLV 150


>gi|118498337 HECT domain containing 1 [Homo sapiens]
          Length = 2610

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 35/102 (34%), Positives = 57/102 (55%), Gaps = 2/102 (1%)

Query: 160 KNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADIN 219
           + + D  R  + D +  AI +   +VN  D+ G+ LL+WA   G +E+V  L +  AD+N
Sbjct: 364 RQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVN 423

Query: 220 CQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
               +  ++LHYA+      + + LL+ GA+P LRD+DG  P
Sbjct: 424 --RGQRSSSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTP 463


>gi|239757617 PREDICTED: similar to hCG1793014 [Homo sapiens]
          Length = 251

 Score = 64.7 bits (156), Expect = 9e-11
 Identities = 29/85 (34%), Positives = 48/85 (56%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYAS 233
           + + +K   +D+N++D + R  LHWAC  G  E+VT+L+  +  ++  D E +T L  A 
Sbjct: 54  LERMMKKTTMDLNIRDAKKRTALHWACANGRAEVVTLLVDRKCQLDILDGENRTTLMKAV 113

Query: 234 ACEFLDIVELLLQSGADPTLRDQDG 258
            C+      +L+ SGADP + D  G
Sbjct: 114 QCQREVCANILIDSGADPNIVDVYG 138



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 22/66 (33%), Positives = 32/66 (48%)

Query: 172 DHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHY 231
           + I + + +KN + N  D+     L  A   G  E+V ++LQ   DI  +D  G  A  Y
Sbjct: 184 EQIVEFLLTKNANANAVDKFKCTALMLAMCHGSSEIVGMVLQENVDICAEDTWGMIAERY 243

Query: 232 ASACEF 237
           A AC F
Sbjct: 244 AVACGF 249


>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform a [Homo sapiens]
          Length = 1030

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 43/151 (28%), Positives = 75/151 (49%), Gaps = 6/151 (3%)

Query: 126 NPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIF-DYCRENNIDHITKAIKSKNVD 184
           N Q+    G E  T    PV+     +  ++ +D  +F   C   + D + K +  +  D
Sbjct: 11  NEQLKRWIGSE--TDLEPPVVKR--QKTKVKFDDGAVFLAACSSGDTDEVLKLLH-RGAD 65

Query: 185 VNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELL 244
           +N  + +G   LH AC   + ++V  L+++ A+IN  DNEG   LH A++C +LDI E L
Sbjct: 66  INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125

Query: 245 LQSGADPTLRDQDGCLPEEVTGCKTVSLVLQ 275
           +  GA     + +G  P ++   + +  +LQ
Sbjct: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 30/116 (25%), Positives = 51/116 (43%), Gaps = 16/116 (13%)

Query: 151 HEETIREEDKNIFDYCRENNIDHITK-AIKSKNVDVNV-KDEEGRALLHWA---CDRGHK 205
           H   +  E     D   E  ++ + +  +  + VD+   + EE R +L  A    + GH 
Sbjct: 131 HVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHI 190

Query: 206 ELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
             V                G TALH A+A  + ++++LL+Q+G D  ++D DG  P
Sbjct: 191 NDVR-----------HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTP 235



 Score = 36.2 bits (82), Expect = 0.033
 Identities = 19/59 (32%), Positives = 29/59 (49%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYA 232
           + K +     DVN+KD +G   LH A   G +E   +L+ +  D+   +  GQTA   A
Sbjct: 214 VLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272



 Score = 35.8 bits (81), Expect = 0.043
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 11/83 (13%)

Query: 153 ETIREEDKNIF--DYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTV 210
           E  R+E++ I   D  +  N  HI     +K+         G   LH A  +G+ E++ +
Sbjct: 167 EAARKEEERIMLRDARQWLNSGHINDVRHAKS---------GGTALHVAAAKGYTEVLKL 217

Query: 211 LLQHRADINCQDNEGQTALHYAS 233
           L+Q   D+N +D +G T LH A+
Sbjct: 218 LIQAGYDVNIKDYDGWTPLHAAA 240


>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform a [Homo sapiens]
          Length = 1030

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 43/151 (28%), Positives = 75/151 (49%), Gaps = 6/151 (3%)

Query: 126 NPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIF-DYCRENNIDHITKAIKSKNVD 184
           N Q+    G E  T    PV+     +  ++ +D  +F   C   + D + K +  +  D
Sbjct: 11  NEQLKRWIGSE--TDLEPPVVKR--QKTKVKFDDGAVFLAACSSGDTDEVLKLLH-RGAD 65

Query: 185 VNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELL 244
           +N  + +G   LH AC   + ++V  L+++ A+IN  DNEG   LH A++C +LDI E L
Sbjct: 66  INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFL 125

Query: 245 LQSGADPTLRDQDGCLPEEVTGCKTVSLVLQ 275
           +  GA     + +G  P ++   + +  +LQ
Sbjct: 126 IGQGAHVGAVNSEGDTPLDIAEEEAMEELLQ 156



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 30/116 (25%), Positives = 51/116 (43%), Gaps = 16/116 (13%)

Query: 151 HEETIREEDKNIFDYCRENNIDHITK-AIKSKNVDVNV-KDEEGRALLHWA---CDRGHK 205
           H   +  E     D   E  ++ + +  +  + VD+   + EE R +L  A    + GH 
Sbjct: 131 HVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHI 190

Query: 206 ELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLP 261
             V                G TALH A+A  + ++++LL+Q+G D  ++D DG  P
Sbjct: 191 NDVR-----------HAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTP 235



 Score = 36.2 bits (82), Expect = 0.033
 Identities = 19/59 (32%), Positives = 29/59 (49%)

Query: 174 ITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYA 232
           + K +     DVN+KD +G   LH A   G +E   +L+ +  D+   +  GQTA   A
Sbjct: 214 VLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA 272



 Score = 35.8 bits (81), Expect = 0.043
 Identities = 25/83 (30%), Positives = 41/83 (49%), Gaps = 11/83 (13%)

Query: 153 ETIREEDKNIF--DYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTV 210
           E  R+E++ I   D  +  N  HI     +K+         G   LH A  +G+ E++ +
Sbjct: 167 EAARKEEERIMLRDARQWLNSGHINDVRHAKS---------GGTALHVAAAKGYTEVLKL 217

Query: 211 LLQHRADINCQDNEGQTALHYAS 233
           L+Q   D+N +D +G T LH A+
Sbjct: 218 LIQAGYDVNIKDYDGWTPLHAAA 240


>gi|239756067 PREDICTED: similar to Putative ankyrin repeat
           domain-containing protein ENSP00000383069 [Homo sapiens]
          Length = 157

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 29/78 (37%), Positives = 44/78 (56%)

Query: 178 IKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEF 237
           +K   +D N++D + R  LHWAC  GH E+VT+L+  +  ++  D E  T L  A  C+ 
Sbjct: 2   MKKTTMDPNIRDAKKRTALHWACANGHAEVVTLLVDRKCQLDVLDGENGTPLMKAVQCQR 61

Query: 238 LDIVELLLQSGADPTLRD 255
                +L+ SGADP + D
Sbjct: 62  EVCANILIDSGADPNIVD 79



 Score = 29.6 bits (65), Expect = 3.1
 Identities = 22/74 (29%), Positives = 30/74 (40%)

Query: 184 DVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVEL 243
           D N+ D      +H+A    +  +V  LL   ADI  ++  G T L  A       IVE 
Sbjct: 74  DPNIVDVYVNTAVHYAVYGENLSVVAKLLSCGADIKVKNKAGHTPLLLAIRKRSEQIVEF 133

Query: 244 LLQSGADPTLRDQD 257
           LL   A+      D
Sbjct: 134 LLTKNANANANSVD 147


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,818,199
Number of Sequences: 37866
Number of extensions: 545606
Number of successful extensions: 3058
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 373
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 956
Number of HSP's gapped (non-prelim): 1787
length of query: 282
length of database: 18,247,518
effective HSP length: 101
effective length of query: 181
effective length of database: 14,423,052
effective search space: 2610572412
effective search space used: 2610572412
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.