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Search of human proteins with 14150165
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14150165 coiled-coil domain containing 77 isoform a [Homo
sapiens]
(488 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14150165 coiled-coil domain containing 77 isoform a [Homo sap... 962 0.0
gi|194306660 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0
gi|194306658 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0
gi|194306535 coiled-coil domain containing 77 isoform b [Homo sa... 896 0.0
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 74 4e-13
gi|34577114 cytomatrix protein p110 [Homo sapiens] 72 1e-12
gi|16262452 cingulin [Homo sapiens] 69 7e-12
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 67 3e-11
gi|38044112 restin isoform b [Homo sapiens] 67 4e-11
gi|4506751 restin isoform a [Homo sapiens] 67 4e-11
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 66 6e-11
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 65 1e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 65 1e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 65 1e-10
gi|21735548 centrosomal protein 2 [Homo sapiens] 65 1e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 65 1e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 64 3e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 64 3e-10
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 64 4e-10
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 64 4e-10
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 64 4e-10
gi|71061468 centromere protein E [Homo sapiens] 64 4e-10
gi|8922940 gamma-taxilin [Homo sapiens] 64 4e-10
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform... 63 5e-10
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 63 5e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 63 7e-10
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 62 9e-10
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 62 9e-10
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 62 1e-09
gi|55770834 centromere protein F [Homo sapiens] 62 1e-09
>gi|14150165 coiled-coil domain containing 77 isoform a [Homo
sapiens]
Length = 488
Score = 962 bits (2486), Expect = 0.0
Identities = 488/488 (100%), Positives = 488/488 (100%)
Query: 1 MNFTPTHTPVCRKRTVVSKRGVAVSGPTKRRGMADSLESTPLPSPEDRLAKLHPSKELLE 60
MNFTPTHTPVCRKRTVVSKRGVAVSGPTKRRGMADSLESTPLPSPEDRLAKLHPSKELLE
Sbjct: 1 MNFTPTHTPVCRKRTVVSKRGVAVSGPTKRRGMADSLESTPLPSPEDRLAKLHPSKELLE 60
Query: 61 YYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQ 120
YYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQ
Sbjct: 61 YYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQ 120
Query: 121 EREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQA 180
EREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQA
Sbjct: 121 EREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQA 180
Query: 181 VGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR 240
VGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR
Sbjct: 181 VGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR 240
Query: 241 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 300
EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE
Sbjct: 241 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 300
Query: 301 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 360
KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS
Sbjct: 301 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 360
Query: 361 NMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGF 420
NMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGF
Sbjct: 361 NMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGF 420
Query: 421 KTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFG 480
KTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFG
Sbjct: 421 KTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFG 480
Query: 481 LENELRLC 488
LENELRLC
Sbjct: 481 LENELRLC 488
>gi|194306660 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 896 bits (2316), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 33 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 92
MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
Query: 93 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 152
LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
Query: 153 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 212
VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
Query: 213 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 272
HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
Query: 273 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 332
KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
Query: 333 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 392
PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
Query: 393 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 452
NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
Query: 453 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488
LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
>gi|194306658 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 896 bits (2316), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 33 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 92
MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
Query: 93 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 152
LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
Query: 153 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 212
VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
Query: 213 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 272
HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
Query: 273 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 332
KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
Query: 333 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 392
PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
Query: 393 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 452
NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
Query: 453 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488
LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
>gi|194306535 coiled-coil domain containing 77 isoform b [Homo
sapiens]
Length = 456
Score = 896 bits (2316), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 33 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 92
MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK
Sbjct: 1 MADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHK 60
Query: 93 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 152
LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL
Sbjct: 61 LECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLAL 120
Query: 153 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 212
VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE
Sbjct: 121 VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSE 180
Query: 213 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 272
HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT
Sbjct: 181 HYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELT 240
Query: 273 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 332
KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL
Sbjct: 241 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 300
Query: 333 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 392
PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT
Sbjct: 301 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 360
Query: 393 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 452
NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA
Sbjct: 361 NKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 420
Query: 453 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488
LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC
Sbjct: 421 LLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 456
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 73.6 bits (179), Expect = 4e-13
Identities = 90/401 (22%), Positives = 185/401 (46%), Gaps = 37/401 (9%)
Query: 59 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 118
L Y Q + + E E DL+ +L K +L+Q +A QK +D +
Sbjct: 134 LYYSQHAVKQLEGEARDLISRLH-------DSWKFAGELEQALSAVAT-QKKKADRYIEE 185
Query: 119 FQEREHVLRLYSENDRLRIRELEDKK-KIQNLLALVGTDAGEVTYFCKEPPHKVT----- 172
+ L L + + EL++K K+Q L LV ++ E+ KE K+
Sbjct: 186 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 245
Query: 173 ILQKTIQA----VGECEQSESSAFKADPKISK--RRPSRERKESSEHYQRDIQTLILQVE 226
+ Q+ +QA +G+ QS S+ +A + ++ R +++++E + IQ +++
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQ 305
Query: 227 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 286
+ ++ EQ + R Q E + E + ++ ++ + KI+EL + +H +++ +
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE-KIRELEEKMHEQEKIREQEE 364
Query: 287 K--DFLQLRSENQNKE---KSWMLEKD--NLMSKIKQYRVQCKKKEDKIGKVLPVMHESH 339
K + ++R + + +E K W E+ KI++ +++E+K+G+ M E
Sbjct: 365 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQE 424
Query: 340 HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL 399
E + ++ QE+K+ +EQ + E+ +IRE+E M +E + + GK
Sbjct: 425 EEMQEQEEKMRR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC 477
Query: 400 QIMTKRYEALERRRILEVEGFKTDIKVLRQ--KLKDLEQML 438
+ K E E+ R E + + + K+ Q K+++ E+M+
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518
Score = 70.5 bits (171), Expect = 3e-12
Identities = 94/464 (20%), Positives = 213/464 (45%), Gaps = 66/464 (14%)
Query: 44 SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLL--KKLELYKEACEGQHKLECDLQQRE 101
SPED H +E L ++ E + + +L +K EL QH ++ Q E
Sbjct: 94 SPEDEQKASHQHQEAL----RRELEAQVQTIRILTCQKTELQMALYYSQHAVK----QLE 145
Query: 102 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 161
E +L L D E E L + + R +E+ K ++ L+L + T
Sbjct: 146 GEARDLISRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNT 201
Query: 162 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR--------PSRERKESSEH 213
+E K LQ+ +Q V +SE S + + K KR+ P ++ + ++H
Sbjct: 202 ITDEELKEKNAKLQEKLQLV----ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 257
Query: 214 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI-EDRRIHLEEIQVQHQRNQNKIKELT 272
+++Q++ +++A + +L+++Q E + ++ +I E ++Q Q + KI+E
Sbjct: 258 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ--EEKIREQE 315
Query: 273 KNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVL 332
+ + +E+++E + E +++ M EK+ + ++++ + +K ++
Sbjct: 316 EKMRRQEEMMWE--------KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ----- 362
Query: 333 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 392
E + E I+ + + QE K+ QE+ I +EE +IRE+E E+ +++
Sbjct: 363 ----EEKRQEEEKIREQEKRQEQEAKMWR--QEEKIREQEE--KIREQE----EMMQEQE 410
Query: 393 NKMGKRLQIMTKRYEALE------RRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNAR 446
KMG++ + M ++ E ++ RR+ ++ + I+ +K+++ E+M+ + +
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ--EEK 468
Query: 447 ANQDLALLCE----VRDSNRRAHKIQGELKNLKSKVFGLENELR 486
+ +CE +++ + + + +++ + K+ E ++R
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Score = 60.5 bits (145), Expect = 3e-09
Identities = 75/361 (20%), Positives = 163/361 (45%), Gaps = 53/361 (14%)
Query: 42 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQRE 101
LP + + H KEL K A+ E ENE L +L +E E + E +Q+RE
Sbjct: 246 LPQQQLQAEADHLGKELQSVSAKLQAQVE-ENE-LWNRLNQQQE--EKMWRQEEKIQERE 301
Query: 102 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRE---LEDKKKIQNLLALVGTDAG 158
E+I E ++ + + + + ++ E ++ + +++R +E E ++KI+ L
Sbjct: 302 EKIQEQEEKIREQEEKMRRQEE---MMWEKEEKMRRQEEMMWEKEEKIREL--------- 349
Query: 159 EVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDI 218
+E H+ Q+ I+ E Q E + + + + ++E + I
Sbjct: 350 ------EEKMHE----QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399
Query: 219 QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHT 278
+ ++ + ++GEQ + EQ E ++E + + +R + KI+E K +
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEE--------EMQEQEEKMRRQEEKIREQEKKIREQ 451
Query: 279 QELLYESTKDFLQLRSENQNKEKSWMLEKDNLMS-----------KIKQYRVQCKKKEDK 327
+E + E ++ +Q + E +++ M E++ M KI++ + +++E+K
Sbjct: 452 EEKIREQ-EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEK 510
Query: 328 IGKVLPVMHESHHAQSEYIKSL--KDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR 385
I + +M E E + + +++ +QE++ QE+ + E+ R+R++E +
Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMREQEVRLRQQEEKMQ 568
Query: 386 E 386
E
Sbjct: 569 E 569
Score = 58.9 bits (141), Expect = 1e-08
Identities = 84/406 (20%), Positives = 184/406 (45%), Gaps = 45/406 (11%)
Query: 56 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 115
K+ Y ++ E +A + +L + +E E KL+ LQ E E +E+Q + +++
Sbjct: 177 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 236
Query: 116 VCLFQEREHVL----RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK---EPP 168
L ER +L +L +E D L K++Q++ A + E + + +
Sbjct: 237 RKL--ERAKLLLPQQQLQAEADHLG-------KELQSVSAKLQAQVEENELWNRLNQQQE 287
Query: 169 HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSR--ERKESSEHYQRDIQTLILQVE 226
K+ ++ IQ E Q + + + +R+ E++E + + ++
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 347
Query: 227 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ----RNQNKIKELTKNLHHTQELL 282
L+ ++ EQ K+ REQ E E+ +I +E + + + R + KI+E + + +E++
Sbjct: 348 ELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406
Query: 283 YESTKDFLQLRSENQNKEKSW-----MLEKDNLM----SKIKQYRVQCKKKEDKIGKVLP 333
E Q + +EK W M E++ M KI++ + +++E+KI +
Sbjct: 407 QE------QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 334 VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR---EIFKD 390
+M E E + ++ + ++ + Q + E+ +IRE+E R E+ ++
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 520
Query: 391 RTNKMGKRLQIMTKRYEAL----ERRRILEVEGFKTDIKVLRQKLK 432
+ KM ++ + M ++ E + E+ R E + + ++++ +Q+ K
Sbjct: 521 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 72.0 bits (175), Expect = 1e-12
Identities = 126/566 (22%), Positives = 243/566 (42%), Gaps = 113/566 (19%)
Query: 14 RTVVSKRGVAVSGPTKRRGMADSLE--STPLPSPEDRLAKLHPSKELLEYYQKKMAECEA 71
R + +R P K + + +E T + S E + L ++L+ E
Sbjct: 357 REELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTE--- 413
Query: 72 ENEDLLKKLELYKEACEGQH----KLECDLQQREEEIAELQKALSDM------------- 114
+ E+ +K++E+YK + +L+ +L ++E E+ LQ L +
Sbjct: 414 DREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEV 473
Query: 115 -QVCLFQEREHVLRLYSENDRLRIRELEDK--------KKIQNLLALVGTDAGEVTYF-- 163
+ L + + L +E D LR+R LE+K K++Q+L GT AGE+
Sbjct: 474 LKESLTAKEQRAAILQTEVDALRLR-LEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKD 532
Query: 164 -CKEPPHKVTILQKTIQAVGE-----------------CEQSESS-----------AFKA 194
+ K+ +LQK I+ + E Q++SS A
Sbjct: 533 MLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSE 592
Query: 195 DPKISKR------RPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE 248
+I +R R RER E E ++++ + L +V ALQA+L E+ E +
Sbjct: 593 KERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEK--------ESSLI 644
Query: 249 DRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD 308
D + H + + +K+K L + +E E +K QL+ + ++ S M
Sbjct: 645 DLKEHASSLASAGLKRDSKLKSLEIAIEQKKE---ECSKLEAQLKKAHNIEDDSRM--NP 699
Query: 309 NLMSKIKQ-------YRVQCKKKEDKIGKVLPVMHESHHAQSEYIK--------SLKDKL 353
+IKQ YR +C K + ++ ++L ++ E + +++ K +L+
Sbjct: 700 EFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMK 759
Query: 354 VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRT---------NKMGKRLQIM-- 402
Q KK++N+ Q + +++ A++ EE R + D + N + K Q +
Sbjct: 760 DQNKKVANLKHNQQLE-KKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDA 818
Query: 403 TKRYEALERRRILEVEGFKTDIKVLRQK-LKDLEQMLYKATVNARANQDLAL-LCEVRDS 460
TK A ++ + E E ++++ R+K L+++ +M +A + A + +D + L E+ S
Sbjct: 819 TKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSAS 878
Query: 461 NRRAHKIQGELKNLKSKVFGLENELR 486
++ K Q E+ LK + L ++L+
Sbjct: 879 KKK--KTQEEVMALKREKDRLVHQLK 902
Score = 35.8 bits (81), Expect = 0.090
Identities = 33/147 (22%), Positives = 71/147 (48%), Gaps = 13/147 (8%)
Query: 305 LEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQ 364
L+K+ ++ K + R+ K++ + V HE + I++L+D+L ++ L+++ Q
Sbjct: 190 LKKERVLRKEEAARMSVLKEQ------MRVSHEENQHLQLTIQALQDELRTQRDLNHLLQ 243
Query: 365 EQCISLEEELARIR-EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTD 423
++ + E I EE RR + ++ K L ++ K E +E L +E K
Sbjct: 244 QESGNRGAEHFTIELTEENFRR--LQAEHDRQAKELFLLRKTLEEME----LRIETQKQT 297
Query: 424 IKVLRQKLKDLEQMLYKATVNARANQD 450
+ + +K L +ML + +++ +D
Sbjct: 298 LNARDESIKKLLEMLQSKGLPSKSLED 324
Score = 31.2 bits (69), Expect = 2.2
Identities = 30/153 (19%), Positives = 60/153 (39%), Gaps = 20/153 (13%)
Query: 326 DKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRR 385
D+ G + H HH ++ ++D + + L+ +L ++ E + R
Sbjct: 119 DQHGGLTGSSHHHHHQVPSMLRQVRDSTM-------------LDLQAQLKELQRENDLLR 165
Query: 386 EIFKDRTNKMGKRLQ-IMTKRYEALERRRILEVEG------FKTDIKVLRQKLKDLEQML 438
+ + +K+G + I T L++ R+L E K ++V ++ + L+ +
Sbjct: 166 KELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTI 225
Query: 439 YKATVNARANQDLALLCEVRDSNRRAHKIQGEL 471
R +DL L + NR A EL
Sbjct: 226 QALQDELRTQRDLNHLLQQESGNRGAEHFTIEL 258
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 69.3 bits (168), Expect = 7e-12
Identities = 95/472 (20%), Positives = 198/472 (41%), Gaps = 74/472 (15%)
Query: 74 EDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND 133
+DLL+ EL +E EG+ ++E L+ RE E+ L+ AL + QE EHV + Y +
Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526
Query: 134 RLRIRELED--------KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECE 185
R ++D + + Q + ALV E+ +E H ++ QK + + +
Sbjct: 527 EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586
Query: 186 Q--------SESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGE-QT 236
Q E + KI + E+ +S R ++ L ++ Q +L E Q
Sbjct: 587 QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646
Query: 237 KLSREQIEGLIEDRRI---------------HLEEIQVQHQRNQNKIKE----------- 270
+ +++ G DR + LEE +Q Q+ ++++
Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706
Query: 271 --------------LTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLE-KDNLMSKIK 315
+ L TQE E + L L E Q KE +++ + + ++++
Sbjct: 707 AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGL--EQQLKETRGLVDGGEAVEARLR 764
Query: 316 QYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ-EKKLSNMYQEQCISLEEEL 374
+ + ++ ++ + L E + + ++L+ +L + ++ L+ + QEQ + L
Sbjct: 765 DKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ-----QTL 819
Query: 375 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDL 434
R EEEG +RE+ + ++ ++ +++ + + L + E K ++ L+ +L+D
Sbjct: 820 NRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDY 879
Query: 435 EQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 486
++ + +A+ + +D A K G L L+ ++ L L+
Sbjct: 880 KEKARREVADAQR--------QAKDWASEAEKTSGGLSRLQDEIQRLRQALQ 923
Score = 39.3 bits (90), Expect = 0.008
Identities = 57/252 (22%), Positives = 116/252 (46%), Gaps = 31/252 (12%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD----LQQRE 101
+D + +L ++ L+ Q + + E L ++L+ ++ E + + + D L+ E
Sbjct: 912 QDEIQRL---RQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLE 968
Query: 102 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL----LALVGTDA 157
E+++ L+ L + + + + V R + D+LR ++++ Q+L ++L +
Sbjct: 969 EKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNK 1028
Query: 158 GEVTYFC-----KEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS- 211
T ++P ++ L+ Q + E Q+E K + + R+ R+ KE S
Sbjct: 1029 DLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEERE-KTVLQSTNRKLERKVKELSI 1087
Query: 212 ------EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRN- 264
+H L L+V+AL+ Q+ E + E+IE L R+ E++ QH+ N
Sbjct: 1088 QIEDERQHVNDQKDQLSLRVKALKRQVDE----AEEEIERLDGLRKKAQREVEEQHEVNE 1143
Query: 265 --QNKIKELTKN 274
Q +IK L K+
Sbjct: 1144 QLQARIKSLEKD 1155
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 67.4 bits (163), Expect = 3e-11
Identities = 110/472 (23%), Positives = 208/472 (44%), Gaps = 88/472 (18%)
Query: 56 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD------------LQQREEE 103
KEL Q +M E ++L K LE KEA Q KLE + L+Q E+E
Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEKEASH-QLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 104 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 163
+LQ +++++ Q+++ + L E L+I L+ K +++N L T A +
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGE---LKIAVLQ-KTELENKLQQQLTQAAQELAA 1009
Query: 164 CKEPPHKVTILQ----------KTIQAVGECEQSESSAFKADPKISKRRPSRERKE--SS 211
KE K+++LQ K +Q+ +SE A + D K + + S +++ S+
Sbjct: 1010 EKE---KISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1066
Query: 212 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 271
+ + LI +++ +A L EQ +EQ +++R L++IQ + + ++
Sbjct: 1067 RNQIGNQNKLIQELKTAKATL-EQDSAKKEQ---QLQERCKALQDIQKEKSLKEKELVNE 1122
Query: 272 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 331
L +E+ K+ +L E ++ + + E NL KQ +Q +K + GK
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNL-KDAKQLLIQ--QKLELQGKA 1179
Query: 332 LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELAR--IREEEGMRREIFK 389
SLK + QEK+ + ++Q EEEL + I +E + EI
Sbjct: 1180 ---------------DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEI-- 1222
Query: 390 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLR-------QKLKDLEQM----- 437
K ++ K++E E + +++ ++ ++ +++ +LE+
Sbjct: 1223 -------KEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275
Query: 438 ----LYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENEL 485
+ +ATV ++ ALL R K +GE++ L++KV L+ +L
Sbjct: 1276 GEIAVLEATVQNNQDERRALL-------ERCLKGEGEIEKLQTKVLELQRKL 1320
Score = 50.8 bits (120), Expect = 3e-06
Identities = 83/464 (17%), Positives = 193/464 (41%), Gaps = 56/464 (12%)
Query: 63 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 122
Q + E + +E+L K+LE Y+ + + K + + E+ L++ L + Q F +
Sbjct: 96 QASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK 155
Query: 123 EHVLRLYSENDRLRIRELED-KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ----KT 177
+ + L+ + E+ D K K +L +VT +E + T++Q +
Sbjct: 156 Q-MKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214
Query: 178 IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTK 237
+Q G + + + + ER+ SE + + + L Q + +A + +
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQL-- 272
Query: 238 LSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQ 297
R ++ ++ ++++E+Q + ++ + ELT+ E L + +D+ +L E
Sbjct: 273 --RSELAKGPQEVAVYVQELQ----KLKSSVNELTQKNQTLTENLLKKEQDYTKLE-EKH 325
Query: 298 NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESH---HAQSEYIKSLKDKL- 353
N+E + K N+ + + Q + C++ + ++ +H H + E + LK++L
Sbjct: 326 NEES---VSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382
Query: 354 ----------VQEKKLSNMYQEQ---CISLEEEL------------------ARIREEEG 382
+ K+L +E+ + L+ E+ R++E+
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ 442
Query: 383 MRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKAT 442
+ E D+ ++ LQ+ R E + ++ + + +Q+ ++ + + T
Sbjct: 443 LSSEKLMDKEQQVAD-LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT 501
Query: 443 VNAR-ANQDL-ALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 484
R A DL +L ++ D +++ ++ L+ K + LE E
Sbjct: 502 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Score = 47.4 bits (111), Expect = 3e-05
Identities = 79/406 (19%), Positives = 168/406 (41%), Gaps = 51/406 (12%)
Query: 105 AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFC 164
A+LQ L Q L +++ + ++ ++ D++ + L+DK++ ++
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK-LQDKQE----------HCSQLESHL 711
Query: 165 KEPPHK-VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLIL 223
KE K +++ QKT + G+ ++ E+ + + + S+E+ QR + T
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEV-------KASKEQALQDLQQQRQLNT--- 761
Query: 224 QVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR--NQNKIKELTKN----LHH 277
+E +L +Q ++ +E + D + E ++ Q+ Q + K++ K L
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 278 TQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHE 337
++ +E + +Q K K +EK+ LM+++ + + K D + +
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVK---MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 338 SHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGK 397
+ I L+ + K + E + ++EL + E+E K N M +
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 398 RL---QIMTKRYEALER--------------RRILEVEGFKTDIKVLRQKLKDLEQMLYK 440
+L Q K+ E E+ ++ ++E + ++K+ + +LE L +
Sbjct: 939 QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 998
Query: 441 ATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENEL 485
+A Q+LA E + K Q K L+S +G E+EL
Sbjct: 999 QL--TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
Score = 45.8 bits (107), Expect = 9e-05
Identities = 69/421 (16%), Positives = 182/421 (43%), Gaps = 24/421 (5%)
Query: 50 AKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQK 109
A LH + Q +++ E + +L E E KL+ +L + E + L+
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELS---EKGEATQKLKEELSEVETKYQHLKA 393
Query: 110 ALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPH 169
+Q ++ +H L+L SE ++L + LE ++++ + + +
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 170 KVTILQKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKESSEHYQ----RDIQTLILQ 224
+V LQ + + E ++ +++ + ++ K + + +++ + R+ Q
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQN---D 510
Query: 225 VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKE---LTKNLHHTQEL 281
+E + Q+G++ + + +E L++ + ++ ++ + + KI+ T L+ QE
Sbjct: 511 LEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 569
Query: 282 LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHA 341
+ + QL + +N+ +S ++NL ++++ + + +D++ + ++E +
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 342 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL-- 399
+E + + +Q K + + + + A ++ + +D+ ++ K
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
Query: 400 --QIMTKRYEALERRRILE--VEGFKTDIKVLRQKLKDLEQMLYKA---TVNARANQDLA 452
Q+ K + E LE ++ +K L QK ++LE + K ++ +A+++ A
Sbjct: 690 LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 453 L 453
L
Sbjct: 750 L 750
Score = 44.7 bits (104), Expect = 2e-04
Identities = 57/301 (18%), Positives = 134/301 (44%), Gaps = 45/301 (14%)
Query: 74 EDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND 133
+D KK + +E C+ ++ + +E+E+ + L++++ ++ + + +L N+
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL---NE 1145
Query: 134 RLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSA-- 191
L+ +LE K+I NL DA K ++Q+ ++ G+ + +++
Sbjct: 1146 ELKSHKLESIKEITNL-----KDA------------KQLLIQQKLELQGKADSLKAAVEQ 1188
Query: 192 FKADPKISKRRPSRERKESSEHY---QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIE 248
K + +I K + +E +E + + + + + I + E + E QI L E
Sbjct: 1189 EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNE 1248
Query: 249 DRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK- 307
+L ++ + Q +Q ++ EL K T +L E L+ +N E+ +LE+
Sbjct: 1249 ----NLGTVKKEWQSSQRRVSELEK---QTDDLRGEIA--VLEATVQNNQDERRALLERC 1299
Query: 308 -------DNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 360
+ L +K+ + + +K ++ V + E+ Q ++ ++L K ++ ++
Sbjct: 1300 LKGEGEIEKLQTKVLELQ---RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Query: 361 N 361
N
Sbjct: 1357 N 1357
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 67.0 bits (162), Expect = 4e-11
Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 43/476 (9%)
Query: 42 LPSPEDRLAKLHPSKELLEYYQKKMAECEAE-NEDLLKKLELYKEACEGQHKLECDLQQR 100
L + ++ L+++ KE LE + + E AE +E+ + +E H+ E
Sbjct: 786 LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 845
Query: 101 EEEIAELQKALSDMQVCLFQEREHVLRLYS-----ENDRLRIRELEDKK-----KIQNLL 150
++ +L++ L+DM+ ++ E +L END I ++ K+ + L
Sbjct: 846 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905
Query: 151 ALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKE 209
L D E+ + + LQK+I+ + + EQS+ A K K + + ERK
Sbjct: 906 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK---KHEEEKKELERKL 962
Query: 210 SSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQ 265
S ++ ++T Q + L+A+ T ++ + E ++++ + L ++++ + N
Sbjct: 963 SD--LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020
Query: 266 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK-----------DNLMSKI 314
++EL + + T + E KEK+ L N + +
Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
Query: 315 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 374
K+ ++ ++ +K ++L V ++ + I++LK Q+ + + QE+ + L EEL
Sbjct: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
Query: 375 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV----LRQK 430
R R+E +++ ++R + + +L M KR + E + I + L +K
Sbjct: 1141 GRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1199
Query: 431 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 486
+LE++ + TV N L V ++ + L+ KV LE +L+
Sbjct: 1200 DAELEKLRNEVTVLRGENASAKSLHSV------VQTLESDKVKLELKVKNLELQLK 1249
Score = 46.6 bits (109), Expect = 5e-05
Identities = 80/409 (19%), Positives = 171/409 (41%), Gaps = 45/409 (11%)
Query: 92 KLECDLQQREEEIAELQKALS--------DMQVCLFQEREHVLRLYSENDRLRIRELEDK 143
+LE DL R +E+AEL++ L DM + L QE + S ++L + + +
Sbjct: 468 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------ISSLQEKLEVTRTDHQ 521
Query: 144 KKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRP 203
++I +L G A E T+ KE T +K + + A K + +
Sbjct: 522 REITSLKEHFG--AREETHQ-KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578
Query: 204 SRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR 263
S+ + H Q + + + L + E +L + QIE + D + +E +Q Q
Sbjct: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMRLDYQHEIENLQNQQDS 637
Query: 264 NQNK-IKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 322
+ KE+ +++ E +RS+ E ++E ++ ++K+++ ++ K
Sbjct: 638 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697
Query: 323 KKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLE--EELARIRE 379
+ L V+ + Q++ I + +L E+KL ++ + S E E+ ++R+
Sbjct: 698 E--------LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 749
Query: 380 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 439
+ + K K L+I + E++G + + L++ L ++ Q
Sbjct: 750 Q--------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 798
Query: 440 KATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENELRL 487
V ++L +L E +++ A +Q ++ +K+ E + +
Sbjct: 799 ---VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 844
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 67.0 bits (162), Expect = 4e-11
Identities = 98/476 (20%), Positives = 204/476 (42%), Gaps = 43/476 (9%)
Query: 42 LPSPEDRLAKLHPSKELLEYYQKKMAECEAE-NEDLLKKLELYKEACEGQHKLECDLQQR 100
L + ++ L+++ KE LE + + E AE +E+ + +E H+ E
Sbjct: 821 LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 880
Query: 101 EEEIAELQKALSDMQVCLFQEREHVLRLYS-----ENDRLRIRELEDKK-----KIQNLL 150
++ +L++ L+DM+ ++ E +L END I ++ K+ + L
Sbjct: 881 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 940
Query: 151 ALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKE 209
L D E+ + + LQK+I+ + + EQS+ A K K + + ERK
Sbjct: 941 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK---KHEEEKKELERKL 997
Query: 210 SSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----EEIQVQHQRNQ 265
S ++ ++T Q + L+A+ T ++ + E ++++ + L ++++ + N
Sbjct: 998 SD--LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055
Query: 266 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK-----------DNLMSKI 314
++EL + + T + E KEK+ L N + +
Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115
Query: 315 KQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEEL 374
K+ ++ ++ +K ++L V ++ + I++LK Q+ + + QE+ + L EEL
Sbjct: 1116 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1175
Query: 375 ARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV----LRQK 430
R R+E +++ ++R + + +L M KR + E + I + L +K
Sbjct: 1176 GRSRDEVTSHQKLEEER-SVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234
Query: 431 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 486
+LE++ + TV N L V ++ + L+ KV LE +L+
Sbjct: 1235 DAELEKLRNEVTVLRGENASAKSLHSV------VQTLESDKVKLELKVKNLELQLK 1284
Score = 46.6 bits (109), Expect = 5e-05
Identities = 80/409 (19%), Positives = 171/409 (41%), Gaps = 45/409 (11%)
Query: 92 KLECDLQQREEEIAELQKALS--------DMQVCLFQEREHVLRLYSENDRLRIRELEDK 143
+LE DL R +E+AEL++ L DM + L QE + S ++L + + +
Sbjct: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE------ISSLQEKLEVTRTDHQ 556
Query: 144 KKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRP 203
++I +L G A E T+ KE T +K + + A K + +
Sbjct: 557 REITSLKEHFG--AREETHQ-KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 613
Query: 204 SRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQR 263
S+ + H Q + + + L + E +L + QIE + D + +E +Q Q
Sbjct: 614 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAEL-KTQIEKMRLDYQHEIENLQNQQDS 672
Query: 264 NQNK-IKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 322
+ KE+ +++ E +RS+ E ++E ++ ++K+++ ++ K
Sbjct: 673 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 732
Query: 323 KKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLE--EELARIRE 379
+ L V+ + Q++ I + +L E+KL ++ + S E E+ ++R+
Sbjct: 733 E--------LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ 784
Query: 380 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 439
+ + K K L+I + E++G + + L++ L ++ Q
Sbjct: 785 Q--------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ--- 833
Query: 440 KATVNARANQDLALLCE-VRDSNRRAHKIQGELKNLKSKVFGLENELRL 487
V ++L +L E +++ A +Q ++ +K+ E + +
Sbjct: 834 ---VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 879
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 66.2 bits (160), Expect = 6e-11
Identities = 74/389 (19%), Positives = 180/389 (46%), Gaps = 40/389 (10%)
Query: 51 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL----ECDLQQREEEIAE 106
K+ +E ++ +++K+ E E + + +K+ +E Q ++ E ++++EE + E
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 107 LQKALSDMQVCLFQEREHVLRLYSE-NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 165
++ + ++ ++++ E + L + +++ +IRE E+K++ +
Sbjct: 361 KEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE----------------- 403
Query: 166 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 225
K+ +K + + + E + + KI ++ R+E H Q I+ +
Sbjct: 404 ----KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQ 459
Query: 226 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 285
E Q ++ Q + REQ E + ++H +E + ++ + K+ + +H +E + E
Sbjct: 460 E--QEEMWRQEEKIREQEEIWRQKEKMHEQE---KIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 286 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESH--HAQS 343
+ R E + +E+ + + KI++ +++E+K+G+ M E Q
Sbjct: 515 EEKMW--RQEEKIREQEEKIREQE--EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570
Query: 344 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 403
E I+ ++K+ ++K+ +E+ EE +IRE+E M +E + + K +
Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEE---KIREQEEMMQEQEEKMWEQEEKMCEQEE 627
Query: 404 KRYEALERRRILEVEGFKTDIKVLRQKLK 432
K E E+ R E + ++ ++++ +Q+ K
Sbjct: 628 KMQEQEEKMRRQEEKMWEQEVRLRQQEEK 656
Score = 62.4 bits (150), Expect = 9e-10
Identities = 90/475 (18%), Positives = 215/475 (45%), Gaps = 65/475 (13%)
Query: 59 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 118
L Y Q + + E E DL+ +L K +L+Q +A QK +D +
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLH-------DSWKFAGELEQALSAVAT-QKKKADRYIEE 197
Query: 119 FQEREHVLRLYSENDRLRIRELEDKK-KIQNLLALVGTDAGEVTYFCKEPPHKVT----- 172
+ L L + + EL++K K+Q L LV ++ E+ KE K+
Sbjct: 198 LTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL 257
Query: 173 ILQKTIQA----VGECEQSESSAFKADPKISK--RRPSRERKESSEHYQRDIQTLILQVE 226
+ Q+ +QA +G+ QS S+ +A + ++ R +++++E + IQ +++
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQ 317
Query: 227 ALQAQLGEQTKLSREQIEGLI---------EDRRIHLEEIQVQHQRN-----------QN 266
+ ++ EQ + REQ E + E++ EE+ + + +
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE 377
Query: 267 KIKELTKNLHHTQELLYESTK----DFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCK 322
KI+EL + +H +++ + K + ++ + + Q +E +++ + + ++ R Q K
Sbjct: 378 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEK 437
Query: 323 K---KEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL----SNMYQEQCISLEEELA 375
K +E+KI + + E + E + ++K+ +++++ M++++ I +EE
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497
Query: 376 RIREEEGM--RREIFKDRTNKMGKRLQIMTKRYEAL--ERRRILEVEGFKTDIKVLRQKL 431
R+EE M + E +++ KM ++ + + ++ E + + +I E E ++ +K+
Sbjct: 498 -WRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEM---MQEQEEKM 553
Query: 432 KDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 486
+ E+ + + R + ++R+ + + + +++ + K++ E ++R
Sbjct: 554 GEQEEKMQEQEKMRRQEE------KIREQEEKIREQKEKIREQEEKIWEQEEKIR 602
Score = 60.8 bits (146), Expect = 3e-09
Identities = 91/445 (20%), Positives = 204/445 (45%), Gaps = 75/445 (16%)
Query: 56 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 115
K+ Y ++ E +A + +L + +E E KL+ LQ E E +E+Q + +++
Sbjct: 189 KKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 248
Query: 116 VCLFQEREHVL----RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK---EPP 168
L ER +L +L +E D L K++Q++ A + E + + +
Sbjct: 249 RKL--ERAKLLLPQQQLQAEADHL-------GKELQSVSAKLQAQVEENELWNRLNQQQE 299
Query: 169 HKVTILQKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKE------------------ 209
K+ ++ IQ E ++ E + + KI ++ R+E
Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 359
Query: 210 SSEHYQRDIQTLILQ----VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ--- 262
E R ++ ++ + + L+ ++ EQ K+ REQ E E+ +I +E + + +
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKM 418
Query: 263 --------RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSW-----MLEKDN 309
+ KI+E K + +E ++E K ++ + Q +E+ W + E++
Sbjct: 419 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK--IREEEKRQEQEEMWRQEEKIREQEE 476
Query: 310 LMSKIKQYRVQ--CKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQ 366
+ + ++ Q +K+E+K+ + E H Q E I+ ++K+ QE+K+ +EQ
Sbjct: 477 IWRQKEKMHEQEKIRKQEEKVWR----QEEKMHDQEEKIREQEEKMWRQEEKI----REQ 528
Query: 367 CISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV 426
+ E+ +IRE+E E+ +++ KMG++ + M ++ + RR+ ++ + I+
Sbjct: 529 EEKIREQEEKIREQE----EMMQEQEEKMGEQEEKMQEQEKM--RRQEEKIREQEEKIRE 582
Query: 427 LRQKLKDLEQMLYKATVNARANQDL 451
++K+++ E+ +++ R +++
Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEM 607
Score = 48.5 bits (114), Expect = 1e-05
Identities = 68/356 (19%), Positives = 157/356 (44%), Gaps = 54/356 (15%)
Query: 56 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 115
+E + ++ M E E + +L +K+ ++ E + K + + + RE+E + Q+A Q
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 421
Query: 116 VCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQ 175
+E+E +R + + ++ +++KI+
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE--------------------------- 454
Query: 176 KTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQ 235
E Q + ++ + KI ++ +KE H Q I+ +V + ++ +Q
Sbjct: 455 ------EEKRQEQEEMWRQEEKIREQEEIWRQKEKM-HEQEKIRKQEEKVWRQEEKMHDQ 507
Query: 236 TKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSE 295
+ REQ + ++ +E +++ Q + KI+E + + +E++ E + + +
Sbjct: 508 EEKIREQ------EEKMWRQEEKIREQ--EEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 296 NQNKEKSWMLEKD--NLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL 353
Q +EK E+ KI++ + + +++E+KI + E Q E ++ ++K+
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE----QEEKIREQEEMMQEQEEKM 615
Query: 354 -VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEA 408
QE+K+ QE+ + +EE R +EE+ +E+ R + +++Q + EA
Sbjct: 616 WEQEEKMCE--QEEKMQEQEEKMRRQEEKMWEQEV---RLRQQEEKMQEHQEHLEA 666
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 65.5 bits (158), Expect = 1e-10
Identities = 96/465 (20%), Positives = 204/465 (43%), Gaps = 72/465 (15%)
Query: 44 SPEDRLAKLHPSKELLEYYQKKMAECEAENEDLL--KKLELYKEACEGQHKLECDLQQRE 101
SPED H +E L ++ E + +L +K EL QH ++ Q E
Sbjct: 106 SPEDEQKASHQHQEAL----RRELEAQVHTIRILTCQKTELQMALYYSQHAVK----QLE 157
Query: 102 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 161
E +L L D E E L + + R +E+ K ++ L+L + T
Sbjct: 158 GEARDLISRLHDSWK-FAGELEQALSAVATQKKKADRYIEELTKERDALSL---ELYRNT 213
Query: 162 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR--------PSRERKESSEH 213
+E K LQ+ +Q V +SE S + + K KR+ P ++ + ++H
Sbjct: 214 ITDEELKEKNAKLQEKLQLV----ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH 269
Query: 214 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI-EDRRIHLEEIQVQHQRN-----QNK 267
+++Q++ +++A + +L+++Q E + ++ +I E ++Q Q + K
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 329
Query: 268 IKELTKNLHHTQELLYESTK------DFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQC 321
I+E + + +E+++E + + + + E +++ M EK+ K+++
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KMRRQEEMM 386
Query: 322 KKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEE 381
+KE+KI ++ MHE + + K +++ ++E++ QEQ + + +IRE+E
Sbjct: 387 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKMWRQEEKIREQE 443
Query: 382 GMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA 441
E +++ KM ++ + + E+ +I E E + ++ RQ+ K EQ
Sbjct: 444 ----EKIREQEKKMWRQEE------KIHEQEKIREEEKRQEQEEMWRQEEKIHEQE---- 489
Query: 442 TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 486
E+ + H+ + +++ + KV+ E ++R
Sbjct: 490 --------------EIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Score = 57.4 bits (137), Expect = 3e-08
Identities = 81/388 (20%), Positives = 179/388 (46%), Gaps = 42/388 (10%)
Query: 56 KELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQQREEEIAELQKALSDM 114
+E + ++KM E E E K+ E K E + + E + ++EE+I E ++ + +
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449
Query: 115 QVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTIL 174
+ ++++ E + +++ +IRE E+K++ Q E + +E H+ +
Sbjct: 450 EKKMWRQEEKI------HEQEKIRE-EEKRQEQ-----------EEMWRQEEKIHEQEEI 491
Query: 175 QKTIQAVGECEQS----ESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQA 230
+ + + E E+ E ++ + KI R + +E E R + + Q E +
Sbjct: 492 WRQKEKMHEQEEKIRKQEEKVWRQEEKI--REQEEKIREQEEKMWRQEEKIREQEEMWRE 549
Query: 231 Q--LGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQ---RNQNKIKELTKNLHHTQELLYE 284
+ + EQ K+ E+ ED+ EE I+ Q + R + KI+E + +E +++
Sbjct: 550 EEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK 609
Query: 285 STKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 344
+ + + Q +E+ +++ KI++ +++E+K+G+ M E E
Sbjct: 610 QEEKIREQEEKIQEQEEKIREQEE----KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Query: 345 YIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTK 404
+++ QE+K+ +EQ + E+ +IRE+E M +E + + K + K
Sbjct: 666 QEETMWR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 718
Query: 405 RYEALERRRILEVEGFKTDIKVLRQKLK 432
E E+ R E + ++ ++++ +Q+ K
Sbjct: 719 MQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/333 (18%), Positives = 160/333 (48%), Gaps = 28/333 (8%)
Query: 63 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 122
++K+ E E + + KK+ +E Q K+ + +++E+E Q+ Q +++++
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 123 EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG 182
E +++ + +++R +E + ++ + + E +E K+ ++ I+
Sbjct: 496 E---KMHEQEEKIRKQEEKVWRQEEKIR--------EQEEKIREQEEKMWRQEEKIREQE 544
Query: 183 ECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQ 242
E + E + + KI + +E+++ + I+ +V + ++ EQ + +EQ
Sbjct: 545 EMWREEEKMHEQE-KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ 603
Query: 243 IEGLI-EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEK 301
E + ++ +I +E ++Q Q + KI+E + + +E+ E + + + E +++
Sbjct: 604 EEKMWKQEEKIREQEEKIQEQ--EEKIREQEEKIREQEEMTQEQEEKMGE-QEEKMCEQE 660
Query: 302 SWMLEKDNLM----SKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK 357
M E++ M KI++ + +++E+KI + +M E Q E + ++K+ +++
Sbjct: 661 EKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQE----QEEKMWEQEEKMCEQE 716
Query: 358 KLSNMYQEQCISLEEEL----ARIREEEGMRRE 386
+ +E+ EE++ R+R++E +E
Sbjct: 717 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 65.5 bits (158), Expect = 1e-10
Identities = 92/416 (22%), Positives = 194/416 (46%), Gaps = 55/416 (13%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 105
+++ AKL +E L+ + + +E + ++L +KLE + KL QQ + E
Sbjct: 281 KEKNAKL---QEKLQLVESEKSEIQLNVKELKRKLE--------RAKLLLPQQQLQAEAD 329
Query: 106 ELQKALSDMQVCL---FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTY 162
L K L + L +E E RL + + R+ E KIQ + ++
Sbjct: 330 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE---KIQEWEEKIQEQEEKI-- 384
Query: 163 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLI 222
+E K+ ++ ++ E + + ++ + + R++ ++++ +
Sbjct: 385 --REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK--- 439
Query: 223 LQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ----RNQNKIKELTKNLHHT 278
+ L+ ++ EQ K+ REQ E E+ +I +E + + + R + KI+E + +
Sbjct: 440 --IRELEEKMHEQEKI-REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496
Query: 279 QELLY---ESTKDFLQLRSENQNKEKSWML---EKDNLMSKIKQYRVQCKKKEDKIGKVL 332
+E ++ E + ++R E + +E+ M EK +I + + + ++E+KI K
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556
Query: 333 PVM---HESHHAQSEYIKSLKDKLV-QEKKLSNMYQEQCISLEEELARIREEEGMRREIF 388
M E H Q E I+ ++K+ QE+K+ QE+ I +EE +IRE+E M +E
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIRE--QEEKIREQEE--KIREQEEMTQE-- 610
Query: 389 KDRTNKMGKRLQIMTKRYEALE------RRRILEVEGFKTDIKVLRQKLKDLEQML 438
+ KMG++ + M ++ E ++ RR+ ++ + I+ +K+++ E+M+
Sbjct: 611 --QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 664
Score = 64.7 bits (156), Expect = 2e-10
Identities = 75/387 (19%), Positives = 178/387 (45%), Gaps = 41/387 (10%)
Query: 51 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL----ECDLQQREEEIAE 106
K+ +E ++ +++K+ E E + + +K+ +E Q ++ E ++++EE + E
Sbjct: 362 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421
Query: 107 LQKALSDMQVCLFQEREHVLRLYSE-NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCK 165
++ + + ++++ E + L + +++ +IRE E+K++ +
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE----------------- 464
Query: 166 EPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 225
K+ +K + + + E + + KI ++ R+E H Q I+ +
Sbjct: 465 ----KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ 520
Query: 226 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 285
E Q ++ Q + REQ E + +IH +E +++ Q + K+ + +H +E + E
Sbjct: 521 E--QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ--EEKMWRQEEKMHDQEEKIREQ 576
Query: 286 TKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEY 345
+ R E + +E+ + + KI++ +++E+K+G+ M E E
Sbjct: 577 EEKVW--RQEEKIREQEEKIREQE--EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 632
Query: 346 IKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKR 405
+ ++ QE+K+ +EQ + E+ +IRE+E M +E + + K + K
Sbjct: 633 EEKMRR---QEEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 685
Query: 406 YEALERRRILEVEGFKTDIKVLRQKLK 432
E E+ R E + ++ ++++ +Q+ K
Sbjct: 686 QEQEEKMRRQEEKMWEQEVRLRQQEEK 712
Score = 48.9 bits (115), Expect = 1e-05
Identities = 66/288 (22%), Positives = 125/288 (43%), Gaps = 55/288 (19%)
Query: 203 PSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR---------EQIEGLIED--RR 251
P E+K S +H + + L QV ++ ++T+L +Q+EG D R
Sbjct: 168 PEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISR 227
Query: 252 IH------------LEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNK 299
+H L + Q ++ I+ELTK LY +T +L+ +N
Sbjct: 228 LHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKL 287
Query: 300 EKSWML---EKDNLMSKIKQYR------------VQCKKKEDKIGKVLPVMHESHHAQSE 344
++ L EK + +K+ + Q + + D +GK L + AQ E
Sbjct: 288 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 347
Query: 345 YIKSLKDKLVQEKKLSNMYQEQCI-----SLEEELARIRE--------EEGMRR--EIFK 389
L ++L Q+++ QE+ I ++E+ +IRE EE MRR E+
Sbjct: 348 E-NELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 406
Query: 390 DRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQM 437
++ KM ++ ++M ++ E + R+ + E + I+ L +K+ + E++
Sbjct: 407 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQEKI 453
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 65.5 bits (158), Expect = 1e-10
Identities = 94/437 (21%), Positives = 193/437 (44%), Gaps = 46/437 (10%)
Query: 51 KLHPSKELLEYYQKKMAECEA-------ENEDLLKKLELYKEACEGQHKLECDLQQREEE 103
KL ++ E Y+ ++ E E+ EN++ K L ++ EA + +H E + E+
Sbjct: 554 KLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV-EKH 612
Query: 104 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 163
EL+ +L Q L+ E+ VL+ + + ++RE +++K L +
Sbjct: 613 KTELE-SLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEM 671
Query: 164 CKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKIS---------KRRPSRERKESSEH 213
++ K+ + Q ++++ E + + K + ++S K+ + E H
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNH 731
Query: 214 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-------IQVQHQRNQN 266
+Q+ + ++I + E + + K Q+E L+++R HL+E ++ +R++
Sbjct: 732 HQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEG 791
Query: 267 KIKELTKNL---HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ--- 320
++++ + L Q +E TK + + ++ Q K E+ L ++ + Q
Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851
Query: 321 -CKKKEDKIGKVLPVMHESHHAQSEYIKSLKD-KLVQEKKL--SNMYQEQC--ISLEEEL 374
C + + +V +M + SE + +K V E KL N QEQ I +E+E
Sbjct: 852 VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911
Query: 375 ARIREEEGMRREIFKDRTNKMGKR---LQIMTKRYEALERRRILEVEGFKTDIK----VL 427
++ EG ++EI + T K+ + + I+ + YE + + ++E K K L
Sbjct: 912 MILQMREGQKKEI-EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETL 970
Query: 428 RQKLKDLEQMLYKATVN 444
++KL D E L K N
Sbjct: 971 KKKLLDQEAKLKKELEN 987
Score = 62.4 bits (150), Expect = 9e-10
Identities = 100/466 (21%), Positives = 192/466 (41%), Gaps = 66/466 (14%)
Query: 42 LPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLE----LYKEACEGQ-HKLECD 96
L + EDRL +K L E +K + A + LL ++E YK+ E +L
Sbjct: 1622 LKALEDRLESESAAK-LAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTK 1680
Query: 97 LQQREEEIAELQKAL-----SDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA 151
LQ+RE E+ L++ L S + + + Y+E + + K + +
Sbjct: 1681 LQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISV 1740
Query: 152 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQSESSAFKADPKISKRRPSRERKES 210
L +T +K +Q VG E E++ SS F+ + +R E E+
Sbjct: 1741 L---------------QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785
Query: 211 SEHYQRDI-------------QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEI 257
+H + + + ++ + ++ + G+ +++ +E + +D + L+E
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845
Query: 258 QVQHQRNQNKIKEL------TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLM 311
++ Q + KIKEL K +H + S + LQ + + K L ++N
Sbjct: 1846 ELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTE 1905
Query: 312 SKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLE 371
K K + VQ K+L M H+ L+ KL ++ ++ + L+
Sbjct: 1906 EKSKSHLVQ--------PKLLSNMEAQHN-------DLEFKLAGAEREKQKLGKEIVRLQ 1950
Query: 372 EELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV-LRQK 430
++L +R+E EI K ++ +R + + + E LE + ++ + L QK
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQ--EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
Query: 431 LKDLEQMLYKATVNARANQDLALL-CEVRDSNRRAHKIQGELKNLK 475
++LE M K T+N + LL ++N+ KI + +LK
Sbjct: 2009 EQELE-MTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053
Score = 57.0 bits (136), Expect = 4e-08
Identities = 102/501 (20%), Positives = 208/501 (41%), Gaps = 60/501 (11%)
Query: 34 ADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAE----NEDLLKKLELYKEACEG 89
+ S ES S + L +L + + EAE N D L K +L +
Sbjct: 87 SSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRM 146
Query: 90 QHKLECDLQQREEEIAE---LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKI 146
+ L + E + LQ+ +Q L Q ++ LR +E + + KK +
Sbjct: 147 ERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHL 206
Query: 147 QN-----------LLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECE---QSESSAF 192
Q ++++ T + + P V +L+ Q + E + E+
Sbjct: 207 QEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPES 266
Query: 193 KADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLS--REQIEGLIEDR 250
+P + + + + +R L E +Q+ + T L+ +E ++ +++R
Sbjct: 267 DGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDER 326
Query: 251 RIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-- 308
LE+I+ H + K+ ++ + E L E K + ++ Q E M E++
Sbjct: 327 LQELEKIKDLHMAEKTKLITQLRDAKNLIEQL-EQDKGMVIAETKRQMHETLEMKEEEIA 385
Query: 309 NLMSKIKQY-------RVQCKKKE----DKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK 357
L S+IKQ R Q +K E +++ K L ++ A+ + +K+ D+ Q K
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRK-LKAEMDE--QIK 442
Query: 358 KLSNMYQEQCISLEEELARIREE---------EGMRREIFKDRTNKMGKRLQIMTKRYEA 408
+ +E+ ISL++EL+R+++E E ++ K ++ ++ Q +TK+ +
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 409 LERRRILEVEGFKTDIKVLRQKLKD--LEQMLYKATVNARANQDLALLCE--VRDSNRRA 464
ER F+ +KV +K + L+ K + A ++L L + + +S +
Sbjct: 503 RERE-------FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKL 555
Query: 465 HKIQGELKNLKSKVFGLENEL 485
+Q E + ++++ LE+ L
Sbjct: 556 RDLQQEAETYRTRILELESSL 576
Score = 54.7 bits (130), Expect = 2e-07
Identities = 95/468 (20%), Positives = 197/468 (42%), Gaps = 64/468 (13%)
Query: 81 ELYKEACEGQHKLECDLQQREEEIAELQK----------------------------ALS 112
+L ++A E Q E LQ++E+E+AEL++ L+
Sbjct: 1050 KLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLN 1109
Query: 113 DMQVCLFQEREHVLRLYSENDRLR--IRELE-DKKKIQNLLALVGTDAGEVTYFCKEPPH 169
++Q L Q+ HV L + +L+ + +LE D K + E+ +E
Sbjct: 1110 ELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKR 1169
Query: 170 KVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEA-L 228
KV+ L ++ E QS S+ + K S S E K+ SE + + EA L
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNK-SLEDKSLEFKKLSEELAIQLDICCKKTEALL 1228
Query: 229 QAQLGEQTKLSREQIEGLI------EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL 282
+A+ E +S + ++ + R ++E + ++++ + L Q L
Sbjct: 1229 EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL 1288
Query: 283 YESTKDFLQLRSENQNKEKSW-------MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 335
S + E +N+ KS + EK+ L + + +KE I ++ +
Sbjct: 1289 NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKEL 1348
Query: 336 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR--REIFKDRTN 393
E+ +A + + LK+K V+ LS + + L+ ++ +E + R+ + +
Sbjct: 1349 SENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC 1408
Query: 394 KMGKRLQIMTKRYEALERRRIL---EVEGFKTDIKVLRQK-----------LKDLE-QML 438
++ ++Q ++ + + L + +I +V+ + ++K +K+L+ Q+
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468
Query: 439 YKATVNARANQDLALLCEVRD-SNRRAHKIQGELKNLKSKVFGLENEL 485
K+ ++ + LL E D N+R ++GE+++ KSK+ E+ L
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Score = 45.8 bits (107), Expect = 9e-05
Identities = 91/486 (18%), Positives = 195/486 (40%), Gaps = 69/486 (14%)
Query: 46 EDRLAKLHPSKELLEYYQ----KKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQQR 100
E++LA+L LE + K++AE EA+ +D+ +L+ +K + + +LE +
Sbjct: 818 EEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877
Query: 101 EEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE-DKKKIQNLLALVGTDAGE 159
E+++ L + +E+E ++ E + + ++ E KK+I+ L +
Sbjct: 878 EQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937
Query: 160 VTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRDI 218
+ +E K +K ++ V + + K + + +E + ++ E Q++
Sbjct: 938 IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997
Query: 219 QTLILQVEALQAQ-LGEQTKLSR------EQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 271
Q +E QA G +SR EQIE L E R L ++ ++ N+ E
Sbjct: 998 QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE 1057
Query: 272 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 331
+ +H Q + EK+ ++++KQ + +++++ K
Sbjct: 1058 LQEIHEIQ------------------------LQEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 332 LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIR------------- 378
+ + E Q + L+++L Q+ N + L+ L ++
Sbjct: 1094 ITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFL 1153
Query: 379 ----EEEGMRREIFKDRTNKMGKRLQIMTKRYEALE---RRRILEVEGFKTDIKVLRQKL 431
E M E K + +++ +L+ + +++L+ + +E + K L ++L
Sbjct: 1154 QEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEEL 1213
Query: 432 --------KDLEQMLYKAT---VNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFG 480
K E +L T +N +++ A+L + R K++ L V
Sbjct: 1214 AIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE 1273
Query: 481 LENELR 486
LE +LR
Sbjct: 1274 LEAQLR 1279
Score = 41.2 bits (95), Expect = 0.002
Identities = 69/313 (22%), Positives = 135/313 (43%), Gaps = 45/313 (14%)
Query: 206 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQ 265
E++ + + DI++L+ + EALQ + G Q + + E+ E I + L E N
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK-ESCITQLKKELSE-------NI 1352
Query: 266 NKIKELTKNLHHTQELLYESTKDFLQLRSENQNK-------------EKSWMLEKDNLMS 312
N + + + L + + +K L + QN K + EK L+
Sbjct: 1353 NAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412
Query: 313 KIK--QYRVQCKKKEDKIGKVLPVMHESH-------HAQSEY------IKSLKDKLVQEK 357
+++ ++V KE KI + V S+ AQS + +K L+ +L +
Sbjct: 1413 QVQDLSFKVDTLSKE-KISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
Query: 358 KLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEV 417
K + EQ L+EEL + + + +D +KM K+ + ++ + RI+E+
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKS-QTARIMEL 1530
Query: 418 EGFKT----DIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-RDSNRRAHKIQGELK 472
E T +I+ L + LK+ Q K + Q L E+ + + R + + ++
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQ--KDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 473 NLKSKVFGLENEL 485
L+++V+ ++ EL
Sbjct: 1589 TLENQVYSMKAEL 1601
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 65.1 bits (157), Expect = 1e-10
Identities = 105/504 (20%), Positives = 215/504 (42%), Gaps = 88/504 (17%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENE-------DLLKKLELYKEACEGQHKLECDLQ 98
E ++A+ +E L + +AE E E E +L K+ E+ K A E L DL+
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE---LLSLDLK 1466
Query: 99 QREEEIAELQKALSDMQVC---------LFQEREHVLRLYSENDRLRIRELE-DKKKIQN 148
+R +E+ Q+ + +++ C QERE L + E +IRELE D++ +N
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQRE----QIRELEKDRETQRN 1522
Query: 149 LLA-----------LVGTDAGEV--------TYFC-----KEPPHKVTILQKTIQAVGEC 184
+L ++ + G+V T C +E HK+ QK I+ +
Sbjct: 1523 VLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQ 1582
Query: 185 EQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIE 244
+++ A + R + +SS+ + + + +L E + ++ K REQIE
Sbjct: 1583 RETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERD--QEVKSQREQIE 1640
Query: 245 GLIEDRR--------------IHLEEIQVQHQRNQNKIKELTKNLHHTQELLYE------ 284
L + + E IQV + + K L ++L + L E
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700
Query: 285 STKDFLQLRSEN---QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHA 341
+ + +Q R+E +K + LE L+ + K+ V+C+++ + + E
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH------IHELQELKDQ 1754
Query: 342 QSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQI 401
+ ++ L K+ + L + +++ + L+++L RE+ ++ + + + ++ + L
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814
Query: 402 MTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN 461
+ EAL++ + + +G + +K +K L+ L +A + + E++D
Sbjct: 1815 RDQELEALQQEQ-QQAQGQEERVK---EKADALQGALEQAHMTLKERHG-----ELQDHK 1865
Query: 462 RRAHKIQGELKNLKSKVFGLENEL 485
+A +++ EL +V LE L
Sbjct: 1866 EQARRLEEELAVEGRRVQALEEVL 1889
Score = 57.0 bits (136), Expect = 4e-08
Identities = 94/486 (19%), Positives = 212/486 (43%), Gaps = 54/486 (11%)
Query: 50 AKLHPSKELLEYYQKKMAECEAENEDLLKK---LELY-KEACEGQHKLECDLQQREEEIA 105
+++ +++ Q +AE E E L +K LE ++A E +L+ DL+ +EE
Sbjct: 631 SRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKE 690
Query: 106 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAG-EVTYFC 164
E+QK LS+ + Q+ +L + + +E + +Q ALV A EV
Sbjct: 691 EIQKKLSESR---HQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747
Query: 165 KEPPHKVTILQKTIQAVGECEQS-ESSAFKADPKISKRRPSRERKE--------SSEHYQ 215
E + L + +Q + ++ ESS F+A + S ++ + E + E Q
Sbjct: 748 VERDRQD--LAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805
Query: 216 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL--TK 273
+++ L L+++ ++Q ++ + Q+ ++ + LE+ + H++ N+++E +
Sbjct: 806 GEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKE 865
Query: 274 NLHHTQELL-----YESTKDFLQLRSENQNKEKSWML-----EKDNLMSKIKQYRVQCKK 323
H QEL E K L++R + Q E + E+ S + Q +++ +K
Sbjct: 866 RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK 925
Query: 324 KEDKIGKVLPVMHESHHAQSEYIKSLKDKL----VQEKKLSNMYQEQCISLEEELARIRE 379
+ + + L + S+ ++ L+ + ++E++ + + Q Q + EL
Sbjct: 926 ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985
Query: 380 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKL-------- 431
+ ++ ++ + + + K+ E L+ + + + + + + +++KL
Sbjct: 986 QHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045
Query: 432 --KDLEQMLYKATVNARANQDLALLCEVRDSNRR---------AHKIQGELKNLKSKVFG 480
K+LE+ T++ + L+ + DS R+ + QGE K L +++
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105
Query: 481 LENELR 486
L E++
Sbjct: 1106 LRQEVK 1111
Score = 50.4 bits (119), Expect = 4e-06
Identities = 89/452 (19%), Positives = 191/452 (42%), Gaps = 53/452 (11%)
Query: 28 TKRRGMADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKL-ELYKEA 86
T+R+ M + E PS R + H +L+ ++K EC+ E+ L++L + ++
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEH--MKLILRDKEKEVECQQEHIHELQELKDQLEQQ 1758
Query: 87 CEGQHKLECD----LQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELED 142
+G H+ + L QRE+EI LQ+ L + + + L+ S +L +
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR------EQGELKEQSLQSQLDEAQRAL 1812
Query: 143 KKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRR 202
++ Q L AL + + + +K G EQ+ + + ++
Sbjct: 1813 AQRDQELEALQQEQQ-------QAQGQEERVKEKADALQGALEQAHMTLKERHGEL---- 1861
Query: 203 PSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQ 262
++ KE + + ++ +V+AL+ LG+ SREQ + L+ + ++ Q Q
Sbjct: 1862 --QDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQ----QQCAEQAQ 1915
Query: 263 RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQ---NKEKSWMLEKDNLMSKIKQYRV 319
++ + + L + Q +L E ++ LR+E+Q ++E++ + L + +
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975
Query: 320 QCKKKEDKIGKVLPVMH----------------ESHHAQSEYIKSLKDKLVQEKKLSNMY 363
+ KE + + + ++H Q E +++ +Q++ L Y
Sbjct: 1976 ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL--RY 2033
Query: 364 QEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQ--IMTKRYEALERRRILEVEGFK 421
QE L++ LA+ EE ++E + + +R+Q ++ ++ + R E+ G
Sbjct: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLH 2093
Query: 422 TDIKVLRQKLKDLEQMLYKATVNARANQDLAL 453
++ L+ L EQ + + + N AL
Sbjct: 2094 QSVRELQLTLAQKEQEILELRETQQRNNLEAL 2125
Score = 46.6 bits (109), Expect = 5e-05
Identities = 107/523 (20%), Positives = 214/523 (40%), Gaps = 83/523 (15%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQH-----------KLE 94
E++ +LH + E Q+ + EA+ + L +L +EA E H ++
Sbjct: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVT 567
Query: 95 CDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKI-----QNL 149
L + E+ IAEL + + ++ + R ++L + N+ L + ++ +++ +N
Sbjct: 568 AALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQ 627
Query: 150 LALVGTDAGEVTY------FCKEPPHKVTILQKTIQAVGECEQSESSA--FKADPK-ISK 200
+A E + + + +K + +++E + +AD + I +
Sbjct: 628 SVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQE 687
Query: 201 RRPSRERKESSEHYQRDIQTLIL---------QVEALQAQLGEQTKLSRE------QIEG 245
+ ++K S +Q++ T L Q E L + E+ L RE +++
Sbjct: 688 EKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQA 747
Query: 246 LIEDRRIHLEEIQ------------VQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ-- 291
+ DR+ E++Q + + QN + E+TK Q K+ +Q
Sbjct: 748 VERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGE 807
Query: 292 ---LRSENQNKEKSWMLEKDNLMSKIKQYR-------VQCKKKEDKIGKVLPVMHESHHA 341
L+ E + E+D ++ Q Q K +K L E +
Sbjct: 808 VRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERS 867
Query: 342 --QSEYIKSL----KDKLVQEKKLSNMYQE-QCISLEEELARIREEEG---MRREIFKDR 391
Q E K+L ++K+ E +L E + I + E R + E M+ E K+R
Sbjct: 868 WHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER 927
Query: 392 TNKMGKRLQIMTKRYEA---LER-RRILEVEGFKTD--IKVLRQKLKDLEQMLYKATVNA 445
+ + LQ + +A LER R+ ++V+ K +L+ +L++ ++ L +A
Sbjct: 928 VSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987
Query: 446 RANQDLALLCEVRDS-NRRAHKIQGELKNLKSKVFGLENELRL 487
R DLA L E S + +Q ++++LKS++ ++ RL
Sbjct: 988 R--DDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRL 1028
Score = 42.7 bits (99), Expect = 7e-04
Identities = 71/328 (21%), Positives = 135/328 (41%), Gaps = 32/328 (9%)
Query: 61 YYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQ 120
++Q+++A+ E +K+EL E Q ++E QREEE + + AL MQ+
Sbjct: 868 WHQQELAKALESLER--EKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL---- 921
Query: 121 EREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQA 180
E ++ R+ LE + Q LA DA + ++ + ++
Sbjct: 922 ----------ETEKERVSLLETLLQTQKELA----DASQQLERLRQDMKVQKLKEQETTG 967
Query: 181 VGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSR 240
+ + + E+ + R +E S +D L QVE L++QL Q R
Sbjct: 968 ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQR 1027
Query: 241 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL---QLRSENQ 297
+ + E R E ++Q + + K + Q LL D + +L + Q
Sbjct: 1028 LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087
Query: 298 NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKI----GKVLPVMHESHHAQSEYIKSLKDKL 353
+ +++ E+ L ++++ R + K+KE ++L + SH + + SL
Sbjct: 1088 DMQEA-QGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL---W 1143
Query: 354 VQEKKLSNMYQEQCISLEEELARIREEE 381
QE K + + Q + S E +L + E+
Sbjct: 1144 AQEAKAAQL-QLRLRSTESQLEALAAEQ 1170
Score = 41.6 bits (96), Expect = 0.002
Identities = 101/515 (19%), Positives = 209/515 (40%), Gaps = 93/515 (18%)
Query: 42 LPSPEDRLAKLHPSKEL----LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 97
L E RL L + + L ++ M E + E ++L ++EL ++ + + E D
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK---EADF 1117
Query: 98 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 157
+E A+L + L + Q R + ++ +L++R + +++ L A
Sbjct: 1118 LAQE---AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA--EQQP 1172
Query: 158 GEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRD 217
G + + LQ+ + +V E S + P + P + S ++R
Sbjct: 1173 GNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSL--FKRG 1230
Query: 218 IQTLILQVEALQAQLG---------EQTK-LSREQIEGL--------IEDRRIH--LEEI 257
L EA+ + L +QT+ + R+Q++ L E ++H L+++
Sbjct: 1231 PLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDL 1290
Query: 258 QVQHQRNQ----------NKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK 307
Q Q +NQ N ++ LH T L + R E Q + + K
Sbjct: 1291 QRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAK 1350
Query: 308 DNLMSKIKQYR---VQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQ 364
+NL ++++ + V+ + + G ++ E +K +++ E++ + Q
Sbjct: 1351 ENLTAQVEHLQAAVVEARAQASAAG----ILEEDLRTARSALKLKNEEVESERERAQALQ 1406
Query: 365 E-------QCISLEEELARI------REEE-----GMRREIFKDR-------------TN 393
E Q +L+E LA + REEE G +E+ K R
Sbjct: 1407 EQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK 1466
Query: 394 KMGKRLQIMTKRYEALER-RRILE-----VEGFKTDIKVLRQKLKDLEQMLYKATVNARA 447
K + + + ++ + LE+ R +LE V+ + + V R+++++LE+ + N
Sbjct: 1467 KRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLE 1525
Query: 448 NQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLE 482
+Q L E+ ++ +G++++LK ++ LE
Sbjct: 1526 HQ----LLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Score = 35.0 bits (79), Expect = 0.15
Identities = 87/464 (18%), Positives = 173/464 (37%), Gaps = 75/464 (16%)
Query: 70 EAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 129
E ++LL +LE ++ CE ++ L+ E+ + KAL RE V +L
Sbjct: 93 EPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKAL----------REDVEKLT 142
Query: 130 SE----NDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPP----HKVTILQKT---- 177
+ D L +E + + + + + + G + +E H + + T
Sbjct: 143 VDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDL 202
Query: 178 IQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTK 237
++ E + S +++ SRE S R+ L+L + Q E +
Sbjct: 203 MELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHE 262
Query: 238 LSREQIE---------GLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKD 288
S+E I+ ++DR L + Q Q+ +++ K L T E+L + +
Sbjct: 263 RSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTE 322
Query: 289 FLQLRSENQNKEKSWMLEKDNLMSKIKQYRV-------QCKKKEDKI------------- 328
++ + + L ++ I Q V Q E+ +
Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQ 382
Query: 329 --GKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGM--- 383
K L ++ + + ++ L+ +L ++ N+ Q+Q EEE +R+
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTG 442
Query: 384 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATV 443
R+ +T + + ++K E L++ R + LRQ+L+ LEQ ++
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKERELLQKAR-----------EELRQQLEVLEQEAWRL-- 489
Query: 444 NARANQDLAL-----LCEVRDSNRRAHKIQGELKNLKSKVFGLE 482
R N +L L + + H E + L+ + GLE
Sbjct: 490 -RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 65.1 bits (157), Expect = 1e-10
Identities = 65/346 (18%), Positives = 161/346 (46%), Gaps = 26/346 (7%)
Query: 72 ENEDLLKKLELYKEACEGQ-HKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYS 130
E E +++ E EGQ + E ++++E ++ E + + + + Q RE ++
Sbjct: 112 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG---QVREQEGQVRE 168
Query: 131 ENDRLRIRE---LEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS 187
+ ++R +E E + +++ +G G++ ++ + +QK + +GE E+
Sbjct: 169 QEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ 228
Query: 188 ESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLI 247
+ E++E + + +Q Q+ + Q+ EQ + REQ E ++
Sbjct: 229 MRK---------QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQML 279
Query: 248 EDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEK 307
+ + +E Q Q Q ++E + + +E + E + + + E K++ M E+
Sbjct: 280 KQKEQTEQEEQTGEQEEQ--MREQEEQMREQEEQMREQEEQMRE-QEEQMGKQEEQMWEQ 336
Query: 308 DNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 367
M + K+ Q K+E+++G+ E Q E ++ ++++ ++++ +EQ
Sbjct: 337 KEQMWEQKE---QMWKQEEQMGE----QEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389
Query: 368 ISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRR 413
EE++ +E+ G ++E +++ +MG++ + M K+ E + ++
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 37.4 bits (85), Expect = 0.031
Identities = 40/213 (18%), Positives = 99/213 (46%), Gaps = 11/213 (5%)
Query: 201 RRPSRERKESSEHYQRDIQTLILQVEALQAQLGE-QTKLSREQIEGLIEDRRIHLEEIQV 259
R + E KE + Q ++Q + + +Q + E + KL ++I L ++ ++ +E QV
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIP-LPQEGQVREQEGQV 61
Query: 260 QHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRV 319
+ Q Q ++E + + + E + E Q +E+ + + ++++
Sbjct: 62 REQEGQ--VREQEGQVREQEGQVREQEGQVRE--QEGQVREQEGQVREQE--GQVREQEG 115
Query: 320 QCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIRE 379
Q +++E ++ + + E E ++++ Q ++ +EQ + E+ ++RE
Sbjct: 116 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 175
Query: 380 EEGMRRE---IFKDRTNKMGKRLQIMTKRYEAL 409
+EG RE +++ +MG++ M ++ E +
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQM 208
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 63.9 bits (154), Expect = 3e-10
Identities = 101/479 (21%), Positives = 206/479 (43%), Gaps = 67/479 (13%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 105
+ ++ L + E +E +++ +E E EN L K L+ +K LE + Q +EE
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Query: 106 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFC 164
EL++ + ++ + + +L EN L + + KK ++ L A T+ EV+Y
Sbjct: 705 ELRRNVESLKCASMK----MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 165 KEPPHKVTILQKTI--------QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 216
+ ++ LQKT+ Q E + E + + + S +R E E +
Sbjct: 761 LDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 217 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 276
++ Q+E + QL ++ K R+Q E I+D + +++ + +N K L+K +
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVKIGNLEKEN--KTLSKEI- 873
Query: 277 HTQELLYESTKDFLQLRSENQNKEKSWMLE-------KDNLMS---KIKQYRVQCKKKED 326
+ ES +L EN+ K ++ +++L+S K +Q +K
Sbjct: 874 ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 327 KIGKV----LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 382
++ K+ ++H+ K L+ KL K S +E+ I+ E AR+ E
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE--ARLEESTN 988
Query: 383 MRREIFKDRTNKMGKRLQIMTKRYEALERRR-----------------ILEVEGFKTDIK 425
+++ ++ L+ + K YEAL++R+ E E +T +
Sbjct: 989 YNQQLRQE--------LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1040
Query: 426 VLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 484
+L+ K + +E AT+ A + AL +++ + + +Q ++ L+ + L+ +
Sbjct: 1041 LLKVKDRLIEVERNNATLQA---EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
Score = 63.5 bits (153), Expect = 4e-10
Identities = 112/489 (22%), Positives = 204/489 (41%), Gaps = 89/489 (18%)
Query: 59 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 118
+E+Y+ ++ E + +N+ LL+ + ++ EG L + E+E +L+ L DM++
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 119 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV--TYFCKEPP-----HKV 171
+R+ + L EN L E+ K+ + L L G + ++ T E P H+V
Sbjct: 399 DMDRKKIEELMEENMTL---EMAQKQSMDESLHL-GWELEQISRTSELSEAPQKSLGHEV 454
Query: 172 TIL------------QKTIQAVGECEQSESSAFKADPKISKRRPSRER------------ 207
L Q + V E + S KI K +R
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 208 ---KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQR 263
K+S ++ Q + L+ + L+ + + S QI+ ++E HL + + QR
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573
Query: 264 NQNKIKELTKNLHHTQELLYESTKDF-----------LQLRSENQN-KEKS--------- 302
+Q + K++ ++L+ES K+ Q++ E ++ KEK
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 303 -WMLEKDN--LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 359
LEK+N L KI ++ C+K E + + + + LK L K L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIE--------ALEQENSELERENRKLKKTLDSFKNL 685
Query: 360 SNMYQEQCISLEEELARIREEE-GMRR--EIFKDRTNKMGKRLQIMTKRYEALERRRILE 416
+ Q SLE+E +++ EE +RR E K + KM +LQ+ K E+ E
Sbjct: 686 T----FQLESLEKENSQLDEENLELRRNVESLKCASMKMA-QLQLENKELES-------E 733
Query: 417 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 476
E K +++L+ K E++ NQ L E +SN++ +++ EL++L+
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--NSNKKIQQLESELQDLEM 791
Query: 477 KVFGLENEL 485
+ L+ L
Sbjct: 792 ENQTLQKNL 800
Score = 63.5 bits (153), Expect = 4e-10
Identities = 97/449 (21%), Positives = 197/449 (43%), Gaps = 57/449 (12%)
Query: 57 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 116
E ++ K+++ E E + K+LE YKE E +LE +L E+E LQK ++++++
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 117 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 176
E + L EN L + KK + + K ++ L+K
Sbjct: 654 TC----EKIEALEQENSELERENRKLKKTLDSF---------------KNLTFQLESLEK 694
Query: 177 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 236
+ E E E K + + ++ + E+ E + + + L +E L+A ++T
Sbjct: 695 ENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKASF-KKT 751
Query: 237 KLSREQIEGL-IEDRRIH--LEEIQVQHQRNQNKIKEL---TKNLHHTQELLYESTKDFL 290
+ +GL IE++R+ LE + Q+ ++++++L + L E L S+K
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 291 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK 350
QL EN++ E+ S++++ + Q +K+ ++ + + + + I +L+
Sbjct: 812 QLEKENKSLEQE--------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 351 DKLVQEKKLSNMYQEQCISLEE------ELAR-----IREEEGMRREIFKD--RTNKMGK 397
+ K +Y+E C+ L+E EL + I+ +R ++ + +T +M
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 398 RLQIMTKRYE--ALERRRILEVEGFKTD--IKVLRQKLKDLEQMLYKATVNARANQDLAL 453
L+ +T E L + R+L E D K+L KL + K ++ + + AL
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL----ESTLKKSLEIKEEKIAAL 979
Query: 454 LCEVRDSNRRAHKIQGELKNLKSKVFGLE 482
+ +S +++ ELK +K L+
Sbjct: 980 EARLEESTNYNQQLRQELKTVKKNYEALK 1008
Score = 47.0 bits (110), Expect = 4e-05
Identities = 88/434 (20%), Positives = 177/434 (40%), Gaps = 62/434 (14%)
Query: 57 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 116
E+ E ++ + E EN+ L K +E + + + + E+E L K + ++
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
Query: 117 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 176
+ QE++ + + QNL K+ + L+K
Sbjct: 513 EIVQEKQSL------------------QNCQNL--------------SKDLMKEKAQLEK 540
Query: 177 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 236
TI+ + E + + + + + + S R+ S Q + + +E L E
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENKILHESI 596
Query: 237 KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 296
K + ++ + ++R +E++ ++ + +EL LHH E + LQ + N
Sbjct: 597 KETSSKLSKIEFEKRQIKKELE-HYKEKGERAEELENELHH-----LEKENELLQKKITN 650
Query: 297 Q--NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL- 353
EK LE++N S++++ + KK D K L ES ++ + +L
Sbjct: 651 LKITCEKIEALEQEN--SELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELR 707
Query: 354 --VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 411
V+ K ++M Q +EL +E+ E+ K + K +RL++ + + +
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQ 766
Query: 412 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLAL-LCEVRDSNRRAHKIQGE 470
R +E I+ L +L+DLE NQ L L E++ S++R +++ E
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEM----------ENQTLQKNLEELKISSKRLEQLEKE 816
Query: 471 LKNLKSKVFGLENE 484
K+L+ + LE +
Sbjct: 817 NKSLEQETSQLEKD 830
Score = 41.2 bits (95), Expect = 0.002
Identities = 74/337 (21%), Positives = 127/337 (37%), Gaps = 65/337 (19%)
Query: 38 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 97
E L S D L K H ELL Q +E E L+ K K A + DL
Sbjct: 1145 EREDLKSLYDSLIKDHEKLELLHERQA------SEYESLISKHGTLKSAHKNLEVEHRDL 1198
Query: 98 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 157
+ R ++ + + L D++ L E+E +L LE+K T A
Sbjct: 1199 EDRYNQLLKQKGQLEDLEKMLKVEQEKML-------------LENKNH--------ETVA 1237
Query: 158 GEVTYFCKEPP---HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHY 214
E C E H + L K + + + + + + K+ + R E + E Y
Sbjct: 1238 AEYKKLCGENDRLNHTYSQLLKETEVL-QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1296
Query: 215 QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 274
Q Q++ +L Q +L Q++G +E+ HL + Q+Q QN+
Sbjct: 1297 Q--------QLDITSTKLNNQCEL-LSQLKGNLEEENRHLLD-QIQTLMLQNR------- 1339
Query: 275 LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPV 334
L +N + + +E+ + K+ + R Q +K E+KI
Sbjct: 1340 ----------------TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1383
Query: 335 MHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 370
S + +I KL++ KK N +++ ++L
Sbjct: 1384 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1420
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 63.9 bits (154), Expect = 3e-10
Identities = 97/448 (21%), Positives = 197/448 (43%), Gaps = 56/448 (12%)
Query: 57 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 116
E ++ K+++ E E + K+LE YKE E +LE +L E+E LQK ++++++
Sbjct: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
Query: 117 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 176
E + L EN L + KK + + K ++ L+K
Sbjct: 654 TC----EKIEALEQENSELERENRKLKKTLDSF---------------KNLTFQLESLEK 694
Query: 177 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 236
+ E E E K + + ++ + E+ E + + + L +E L+A ++T
Sbjct: 695 ENSQLDE-ENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKASF-KKT 751
Query: 237 KLSREQIEGL-IEDRRIH--LEEIQVQHQRNQNKIKEL---TKNLHHTQELLYESTKDFL 290
+ +GL IE++R+ LE + Q+ ++++++L + L E L S+K
Sbjct: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 291 QLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK 350
QL EN++ E+ S++++ + Q +K+ ++ + + + + I +L+
Sbjct: 812 QLEKENKSLEQE--------TSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Query: 351 DKLVQEKKLSNMYQEQCISLEE------ELAR-----IREEEGMRREIFKD--RTNKMGK 397
+ K +Y+E C+ L+E EL + I+ +R ++ + +T +M
Sbjct: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
Query: 398 RLQIMTKRYE--ALERRRILEVEGFKTD-IKVLRQKLKDLEQMLYKATVNARANQDLALL 454
L+ +T E L + R+L E D K+L KL + K ++ + + AL
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL----ESTLKKSLEIKEEKIAALE 979
Query: 455 CEVRDSNRRAHKIQGELKNLKSKVFGLE 482
+ +S +++ ELK +K L+
Sbjct: 980 ARLEESTNYNQQLRQELKTVKKNYEALK 1007
Score = 63.5 bits (153), Expect = 4e-10
Identities = 112/489 (22%), Positives = 204/489 (41%), Gaps = 89/489 (18%)
Query: 59 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCL 118
+E+Y+ ++ E + +N+ LL+ + ++ EG L + E+E +L+ L DM++
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
Query: 119 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV--TYFCKEPP-----HKV 171
+R+ + L EN L E+ K+ + L L G + ++ T E P H+V
Sbjct: 399 DMDRKKIEELMEENMTL---EMAQKQSMDESLHL-GWELEQISRTSELSEAPQKSLGHEV 454
Query: 172 TIL------------QKTIQAVGECEQSESSAFKADPKISKRRPSRER------------ 207
L Q + V E + S KI K +R
Sbjct: 455 NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEI 514
Query: 208 ---KESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEE-IQVQHQR 263
K+S ++ Q + L+ + L+ + + S QI+ ++E HL + + QR
Sbjct: 515 VQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIK-ILEQENEHLNQTVSSLRQR 573
Query: 264 NQNKIKELTKNLHHTQELLYESTKDF-----------LQLRSENQN-KEKS--------- 302
+Q + K++ ++L+ES K+ Q++ E ++ KEK
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 303 -WMLEKDN--LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 359
LEK+N L KI ++ C+K E + + + + LK L K L
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIE--------ALEQENSELERENRKLKKTLDSFKNL 685
Query: 360 SNMYQEQCISLEEELARIREEE-GMRR--EIFKDRTNKMGKRLQIMTKRYEALERRRILE 416
+ Q SLE+E +++ EE +RR E K + KM +LQ+ K E+ E
Sbjct: 686 T----FQLESLEKENSQLDEENLELRRNVESLKCASMKMA-QLQLENKELES-------E 733
Query: 417 VEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKS 476
E K +++L+ K E++ NQ L E +SN++ +++ EL++L+
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE--NSNKKIQQLESELQDLEM 791
Query: 477 KVFGLENEL 485
+ L+ L
Sbjct: 792 ENQTLQKNL 800
Score = 63.2 bits (152), Expect = 5e-10
Identities = 102/479 (21%), Positives = 207/479 (43%), Gaps = 68/479 (14%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 105
+ ++ L + E +E +++ +E E EN L K L+ +K LE + Q +EE
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENL 704
Query: 106 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLA-LVGTDAGEVTYFC 164
EL++ + ++ + + +L EN L + + KK ++ L A T+ EV+Y
Sbjct: 705 ELRRNVESLKCASMK----MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG 760
Query: 165 KEPPHKVTILQKTI--------QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 216
+ ++ LQKT+ Q E + E + + + S +R E E +
Sbjct: 761 LDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 217 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 276
++ Q+E + QL ++ K R+Q E I+D + +++ + +N K L+K +
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVKIGNLEKEN--KTLSKEI- 873
Query: 277 HTQELLYESTKDFLQLRSENQNKEKSWMLE-------KDNLMS---KIKQYRVQCKKKED 326
+ ES +L EN+ K ++ +++L+S K +Q +K
Sbjct: 874 ---GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 327 KIGKV----LPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 382
++ K+ ++H+ Y K L+ KL K S +E+ I+ E AR+ E
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDRY-KLLESKLESTLKKSLEIKEEKIAALE--ARLEESTN 987
Query: 383 MRREIFKDRTNKMGKRLQIMTKRYEALERRR-----------------ILEVEGFKTDIK 425
+++ ++ L+ + K YEAL++R+ E E +T +
Sbjct: 988 YNQQLRQE--------LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
Query: 426 VLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 484
+L+ K + +E AT+ A + AL +++ + + +Q ++ L+ + L+ +
Sbjct: 1040 LLKVKDRLIEVERNNATLQA---EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095
Score = 47.0 bits (110), Expect = 4e-05
Identities = 88/434 (20%), Positives = 177/434 (40%), Gaps = 62/434 (14%)
Query: 57 ELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQV 116
E+ E ++ + E EN+ L K +E + + + + E+E L K + ++
Sbjct: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
Query: 117 CLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQK 176
+ QE++ + + QNL K+ + L+K
Sbjct: 513 EIVQEKQSL------------------QNCQNL--------------SKDLMKEKAQLEK 540
Query: 177 TIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 236
TI+ + E + + + + + + S R+ S Q + + +E L E
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENKILHESI 596
Query: 237 KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 296
K + ++ + ++R +E++ ++ + +EL LHH E + LQ + N
Sbjct: 597 KETSSKLSKIEFEKRQIKKELE-HYKEKGERAEELENELHH-----LEKENELLQKKITN 650
Query: 297 Q--NKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL- 353
EK LE++N S++++ + KK D K L ES ++ + +L
Sbjct: 651 LKITCEKIEALEQEN--SELERENRKLKKTLDSF-KNLTFQLESLEKENSQLDEENLELR 707
Query: 354 --VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 411
V+ K ++M Q +EL +E+ E+ K + K +RL++ + + +
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQ 766
Query: 412 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLAL-LCEVRDSNRRAHKIQGE 470
R +E I+ L +L+DLE NQ L L E++ S++R +++ E
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEM----------ENQTLQKNLEELKISSKRLEQLEKE 816
Query: 471 LKNLKSKVFGLENE 484
K+L+ + LE +
Sbjct: 817 NKSLEQETSQLEKD 830
Score = 41.2 bits (95), Expect = 0.002
Identities = 74/337 (21%), Positives = 127/337 (37%), Gaps = 65/337 (19%)
Query: 38 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 97
E L S D L K H ELL Q +E E L+ K K A + DL
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQA------SEYESLISKHGTLKSAHKNLEVEHRDL 1197
Query: 98 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 157
+ R ++ + + L D++ L E+E +L LE+K T A
Sbjct: 1198 EDRYNQLLKQKGQLEDLEKMLKVEQEKML-------------LENKNH--------ETVA 1236
Query: 158 GEVTYFCKEPP---HKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHY 214
E C E H + L K + + + + + + K+ + R E + E Y
Sbjct: 1237 AEYKKLCGENDRLNHTYSQLLKETEVL-QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1295
Query: 215 QRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN 274
Q Q++ +L Q +L Q++G +E+ HL + Q+Q QN+
Sbjct: 1296 Q--------QLDITSTKLNNQCEL-LSQLKGNLEEENRHLLD-QIQTLMLQNR------- 1338
Query: 275 LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPV 334
L +N + + +E+ + K+ + R Q +K E+KI
Sbjct: 1339 ----------------TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1382
Query: 335 MHES-HHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 370
S + +I KL++ KK N +++ ++L
Sbjct: 1383 YDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1419
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 63.5 bits (153), Expect = 4e-10
Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 67/482 (13%)
Query: 55 SKEL---LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL---QQRE-----EE 103
S+EL LE + K+ E +++ L+ L+ E+ + Q L+ +L QQ++ ++
Sbjct: 3217 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLES-QKQRNLQLNLLLEQQKQLLNESQQ 3275
Query: 104 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE---DKKKIQNLLALVGTDAGEV 160
E Q+ L D Q+ Q R L++ E++++RIRE+ D+++ + G+
Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ- 3334
Query: 161 TYFCKEPPHKVTILQKTIQAVGECEQS-------ESSAFKADPKISKRRPSRERKESSEH 213
PP L K +Q E + S E+ +K D ++++ ++R+ +
Sbjct: 3335 ----SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3390
Query: 214 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 273
Q + + E + Q+K+ E ++ +E++R + ++ ++ QR Q ++E K
Sbjct: 3391 LQTEQEA---NTEGQKKMHELQSKV--EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3445
Query: 274 NLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 333
QEL E ++ ++ +N N+ +W L D + + Q +++ + KE K++
Sbjct: 3446 -----QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIE 3500
Query: 334 VMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLEEELARIREEEGMRREI----- 387
M+ + ++ ++ KL KL + Q+ L+ E A + ++ I
Sbjct: 3501 -MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIIL 3559
Query: 388 -FKDRTNKMGKRLQIMTKRYE--ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA--- 441
+ T + G+ +++ +L R + + I L ++ DL M+ K
Sbjct: 3560 QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3619
Query: 442 -----------------TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 484
++N AN + + E NR +Q LK +++V+ L+ E
Sbjct: 3620 IRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3679
Query: 485 LR 486
LR
Sbjct: 3680 LR 3681
Score = 57.0 bits (136), Expect = 4e-08
Identities = 102/520 (19%), Positives = 216/520 (41%), Gaps = 109/520 (20%)
Query: 59 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD-------LQQREEEIAELQKAL 111
+E QK+ + D+++++E + Q + E D +Q ++E I + +
Sbjct: 401 VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQM 460
Query: 112 SDMQVCLFQEREHVLRLYSE----NDRLRIR---------ELED----KKKIQNLLALVG 154
+M+ E E+ LR YS D++++ +L+D K+K++ L L+
Sbjct: 461 EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLIL 520
Query: 155 TDAGEVTYFCKEPPHKVTI----LQKTIQAVGECEQSESSAFKA-----DPKISKRRPSR 205
+ + ++ +++ +Q+ Q + E E + A K+ D K S
Sbjct: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580
Query: 206 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------- 254
RKE ++ ++ +++E L+ + E E +E R L
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640
Query: 255 -EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 313
E+++++H+ N K+K+ +H+ Q++ D LQ +E K ++ EKDNL++K
Sbjct: 641 KEDLEIEHRINIEKLKD-NLGIHYKQQI------DGLQ--NEMSQKIETMQFEKDNLITK 691
Query: 314 IKQYRVQCKKKED------------------KIGKVLPVMHESHHAQSEYIKSLKDKLVQ 355
Q ++ K +D ++ K + ++ + + + +++ ++
Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751
Query: 356 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRIL 415
+ L +E+ L+E+ A++ E I KD + L+I T + R++
Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAE----NSILKDEKKTLEDMLKIHT---PVSQEERLI 804
Query: 416 EVEGFKT---------DIKVLRQKLKDLEQMLYK--------------ATVNARAN---- 448
++ K+ +I++L ++ +DL+Q + A N N
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Query: 449 -QDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 487
++ A L +V+D + K + EL+ KSK+ L EL L
Sbjct: 865 QEEYACLLKVKD-DLEDSKNKQELE-YKSKLKALNEELHL 902
Score = 55.1 bits (131), Expect = 1e-07
Identities = 81/458 (17%), Positives = 193/458 (42%), Gaps = 38/458 (8%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACE----GQHKLECDLQQRE 101
+ + KL +++ +Q E E L L+ + C + +L+ D+Q+R
Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143
Query: 102 EEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 161
EEI +L+ + +++ L + ++ DR +E K ++ +L + + +
Sbjct: 2144 EEIEKLEFRVRELEQALLVSADTFQKV---EDRKHFGAVEAKPEL-SLEVQLQAERDAID 2199
Query: 162 YFCKEPPHKVTILQKTIQAVG---ECEQSESSAFKADPKISKRRPS---RERKESSEHYQ 215
KE +T L++ ++ E + E +I K+ + +E ++ ++ ++
Sbjct: 2200 RKEKE----ITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFK 2255
Query: 216 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKN- 274
D++ L L ++ A + + + +I+++ + ++++ Q + Q ++K T N
Sbjct: 2256 DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNK 2315
Query: 275 -LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 333
+ EL+ + L S+ + K N +I+Q +K + ++ +
Sbjct: 2316 VIEEKNELIRDLETQIECLMSDQE-------CVKRNREEEIEQLNEVIEKLQQELANIGQ 2368
Query: 334 VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKD--- 390
+ H+ SE SLK +L ++ + ++LE+++ EE + + K+
Sbjct: 2369 KTSMNAHSLSEEADSLKHQL-------DVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2421
Query: 391 RTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQD 450
+ N++ + L + + E++E+ + + I L + +LE +L + + + NQ
Sbjct: 2422 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQT 2481
Query: 451 LALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488
E + ++ L L+S V + EL C
Sbjct: 2482 YFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQC 2518
Score = 52.8 bits (125), Expect = 7e-07
Identities = 100/510 (19%), Positives = 203/510 (39%), Gaps = 99/510 (19%)
Query: 51 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYK----EACEGQHKLECDLQQREEEIAE 106
+L LLE YQKK + + L +K+++Y+ + E +K E +Q++E I E
Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE--IQEKETIIEE 333
Query: 107 L---------------------QKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKK 145
L K L ++Q + Q+ + + + E + +E + ++
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
Query: 146 IQNLLALVGT-----------DAGEVTYFCKEPPHKVTILQKTI-----QAVGECEQSES 189
I+ L+ V + V +E K+ L+ + Q + + +Q
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 190 SAFKADPKISKRRPSRERKESSEHYQR--------------------DIQTLILQVEALQ 229
A + K R E + + Y +Q Q E L+
Sbjct: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK 513
Query: 230 AQLG---EQTKLSREQIEGLIEDRRIHLEEIQVQHQ---RNQNKIKELTKNLHHTQELLY 283
+LG E+ + Q+E L+E+ E+IQ Q ++K+ E K+L ++L
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573
Query: 284 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQS 343
E + R E + K + +++ Y+++ + E + VL M ES A+
Sbjct: 574 EIV-SASESRKELELKHE----------AEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622
Query: 344 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR-REIFKDRTNKMGKRLQIM 402
E +++ + E++LS + ++ I + ++++ G+ ++ N+M ++++ M
Sbjct: 623 ERLRT-QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681
Query: 403 TKRYEAL---ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-- 457
+ L + + ILE+ KLKDL+Q L + Q L E+
Sbjct: 682 QFEKDNLITKQNQLILEI-----------SKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
Query: 458 -RDSNRRAHKIQGELKNLKSKVFGLENELR 486
R + ++ E++ L+ K LE +++
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
Score = 51.6 bits (122), Expect = 2e-06
Identities = 88/410 (21%), Positives = 186/410 (45%), Gaps = 63/410 (15%)
Query: 56 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 115
+ LL Q A+ L ++ E K + Q LE ++QQ++ ++ E+Q LS M
Sbjct: 3088 RSLLSEIQALHAQMNGRKITLKREQESEKPS---QELLEYNIQQKQSQMLEMQVELSSM- 3143
Query: 116 VCLFQEREHVLRLYSENDRLRIREL-----EDKKKIQNLLALVGTDAGEVTYF---CKEP 167
++R L+ ++++ + EL + K +++ L E+ F K+
Sbjct: 3144 ----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3199
Query: 168 PHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER-KESSEHYQRDIQT---LIL 223
+V +L T+ E ++S + + + +K S ER KE E + +++ L
Sbjct: 3200 TDEVHLLNDTL--ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3257
Query: 224 QVEALQAQLGEQTKLSREQIEG--LIEDRRIHLE-----EIQVQHQRNQNKIKELTKNLH 276
Q+ L Q + S+++IE ++ D ++ E E+QV + + +I+E++ L
Sbjct: 3258 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3317
Query: 277 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 336
+EL QL+S + + L ++L+ +++ K+ E+K +++ +++
Sbjct: 3318 REREL-------HAQLQSSDGTGQSRPPLPSEDLLKELQ------KQLEEKHSRIVELLN 3364
Query: 337 ESHHAQSEYIKSL----KDKLVQEKKLSNMYQ---------EQCISLEEELARIREEEGM 383
E+ + + +++ KD+ V K L + + S E+L R EE+
Sbjct: 3365 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3422
Query: 384 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 433
R++++K + G+RLQ + + ++ E LE E + ++L Q L +
Sbjct: 3423 RQQVYK--LDLEGQRLQGIMQEFQKQE----LEREEKRESRRILYQNLNE 3466
Score = 44.7 bits (104), Expect = 2e-04
Identities = 100/489 (20%), Positives = 196/489 (40%), Gaps = 86/489 (17%)
Query: 54 PSKELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQ------QREEE--- 103
PS++LL+ QK++ E + +LL + E YK ++ + + ++E D Q Q E+E
Sbjct: 3340 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3399
Query: 104 -----IAELQKALSDMQVCLFQEREHVLRLYSENDRL-------RIRELEDKKKIQNLLA 151
+ ELQ + D+Q L ++R+ V +L E RL + +ELE ++K ++
Sbjct: 3400 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3459
Query: 152 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE----------------------- 188
L T+ + +LQ+ I+ GE ++S
Sbjct: 3460 LYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIEMNGGGTGCNHELEMIRQ 3517
Query: 189 -----SSAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVEALQAQLGEQTKL-SR 240
+S + P+ + R E + + Q +I +ILQ++ L Q GE+ L S
Sbjct: 3518 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSP 3577
Query: 241 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 300
G + +R + Q+ I +LT+ + + ++ + + R ++
Sbjct: 3578 STSCGSLTERLLR------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3631
Query: 301 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 360
S + +L + +KE + L + A++E K LK +L + L
Sbjct: 3632 NS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK-LKAELRNDSLL- 3686
Query: 361 NMYQEQCISLEEELARIREEEG--MRREIFKDRTNKMGKRLQIMTKRYEALERRRI---- 414
Q +S + E ++ G +R E F+ K L ++ ++ E +
Sbjct: 3687 -----QTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLA 3741
Query: 415 -LEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELK- 472
+ + TD++V+ + K + V+ ++ L+ RR H++ G +
Sbjct: 3742 RMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLV-------RRWHRVTGSVSI 3794
Query: 473 NLKSKVFGL 481
N+ FGL
Sbjct: 3795 NINRDGFGL 3803
Score = 40.8 bits (94), Expect = 0.003
Identities = 89/391 (22%), Positives = 157/391 (40%), Gaps = 65/391 (16%)
Query: 37 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 96
L+ P + E L PS+ + QK++ ++E DL ++E + + D
Sbjct: 1072 LDHLPSVTKESSLRATQPSEN--DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129
Query: 97 LQQREEEIAELQKALSDM-QVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLA 151
Q RE E KAL + + +F + E + L E ++ +E D+ K +LL
Sbjct: 1130 -QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
Query: 152 --LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPS--RER 207
L + E +YF + ++L + +CE + + IS+ ++
Sbjct: 1189 GKLQKAVSEECSYFLQT---LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245
Query: 208 KESSEHYQRDIQTLILQVE-------ALQAQL----GEQT----------KLSREQIEGL 246
+ + +Q ++ TL+ +V LQ +L G+QT L +E+ E L
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305
Query: 247 -IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL--QLRSENQNKEKSW 303
I + +LE+I V H+ + +++L K Q ES L QL+ QN E
Sbjct: 1306 SIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEI 1365
Query: 304 MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS--------------- 348
+ L + + + V D + V+ ES ++ Y S
Sbjct: 1366 HCLQKRLQA-VSESTVPPSLPVDSV-----VITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
Query: 349 --LKDKLVQEKKLSNMYQEQCISLEEELARI 377
+K++ K L YQEQ LEEE+A++
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQ---LEEEVAKV 1447
Score = 40.8 bits (94), Expect = 0.003
Identities = 67/315 (21%), Positives = 135/315 (42%), Gaps = 47/315 (14%)
Query: 90 QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL 149
+ +L D+ I+EL+ + +M L E+E V + +N LE +KK+ L
Sbjct: 2594 EDELGSDISALTLRISELESQVVEMHTSLILEKEQV-EIAEKN------VLEKEKKLLEL 2646
Query: 150 LALV-GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS----ESSAFKADPKISKRRPS 204
L+ G + + K P V +L+ T + E+S E A +A+ ++ +
Sbjct: 2647 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE-SVATKAEL 2705
Query: 205 RERKESSEHYQRDIQTLILQVEALQ---AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQH 261
KE +E Q ++ + +LQ +Q+ + ++E++ L ++ +E +VQ
Sbjct: 2706 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-----DETEVQE 2760
Query: 262 QRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-----NLMSK--- 313
+ + L L + + T L++ S NQ + +L K+ NL S+
Sbjct: 2761 SKKACMFEPLPIKL---SKSIASQTDGTLKISSSNQTPQ---ILVKNAGIQINLQSECSS 2814
Query: 314 ------IKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 367
I Q+ + +K ++ + M H +++E +K VQ + +E+C
Sbjct: 2815 EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ------LLKEEC 2868
Query: 368 ISLEEELARIREEEG 382
+L+ + +R +EG
Sbjct: 2869 GTLKAVIQCLRSKEG 2883
Score = 36.2 bits (82), Expect = 0.069
Identities = 61/334 (18%), Positives = 136/334 (40%), Gaps = 86/334 (25%)
Query: 225 VEALQAQL-GEQTKLSREQIEGLIEDRRI--------HLEEIQVQHQRNQNKIKELTKNL 275
+E ++++L G+Q ++ E++ +E+ R+ L+E + ++ I +LT NL
Sbjct: 157 LEMMESELAGKQHEI--EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214
Query: 276 HHTQELLYESTKDFLQLRSEN--------------------------------------- 296
+ E+ ++FL+L ++
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 297 -------------QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK--------VLPVM 335
Q K++ + ++ L KIK Y ++ KK + K ++ +
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 336 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 395
+ + + LKDKL KL QEQ + +E+ ++ + K + +
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK----LELTNSKQKERQS 390
Query: 396 GKRLQIMTKRYEALERRRILEVEGFKTDI--KVLRQKLKDLEQMLYKATVNARANQDLAL 453
+ ++ + E L++R + + F+TDI ++ ++ + LEQ+ +A ++ Q +
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQ-FETDIVQRMEQETQRKLEQL--RAELDEMYGQQIV- 446
Query: 454 LCEVRDSNRRAHKIQGELKNLKSKVFG-LENELR 486
+++ R H Q ++ +K++ G +EN LR
Sbjct: 447 --QMKQELIRQHMAQ--MEEMKTRHKGEMENALR 476
Score = 30.0 bits (66), Expect = 5.0
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 15/76 (19%)
Query: 74 EDLLKKLEL--YKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 131
E + K EL YKE E KL+ +L +E + LQK LS Q R+H L
Sbjct: 2697 ESVATKAELASYKEKAE---KLQEELLVKETNMTSLQKDLS-------QVRDH---LAEA 2743
Query: 132 NDRLRIRELEDKKKIQ 147
++L I E ED+ ++Q
Sbjct: 2744 KEKLSILEKEDETEVQ 2759
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 63.5 bits (153), Expect = 4e-10
Identities = 100/482 (20%), Positives = 208/482 (43%), Gaps = 67/482 (13%)
Query: 55 SKEL---LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL---QQRE-----EE 103
S+EL LE + K+ E +++ L+ L+ E+ + Q L+ +L QQ++ ++
Sbjct: 3209 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLES-QKQRNLQLNLLLEQQKQLLNESQQ 3267
Query: 104 IAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELE---DKKKIQNLLALVGTDAGEV 160
E Q+ L D Q+ Q R L++ E++++RIRE+ D+++ + G+
Sbjct: 3268 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ- 3326
Query: 161 TYFCKEPPHKVTILQKTIQAVGECEQS-------ESSAFKADPKISKRRPSRERKESSEH 213
PP L K +Q E + S E+ +K D ++++ ++R+ +
Sbjct: 3327 ----SRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3382
Query: 214 YQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTK 273
Q + + E + Q+K+ E ++ +E++R + ++ ++ QR Q ++E K
Sbjct: 3383 LQTEQEA---NTEGQKKMHELQSKV--EDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQK 3437
Query: 274 NLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLP 333
QEL E ++ ++ +N N+ +W L D + + Q +++ + KE K++
Sbjct: 3438 -----QELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIE 3492
Query: 334 VMHESHHAQSEYIKSLKDKL-VQEKKLSNMYQEQCISLEEELARIREEEGMRREI----- 387
M+ + ++ ++ KL KL + Q+ L+ E A + ++ I
Sbjct: 3493 -MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIIL 3551
Query: 388 -FKDRTNKMGKRLQIMTKRYE--ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA--- 441
+ T + G+ +++ +L R + + I L ++ DL M+ K
Sbjct: 3552 QLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQ 3611
Query: 442 -----------------TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 484
++N AN + + E NR +Q LK +++V+ L+ E
Sbjct: 3612 IRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAE 3671
Query: 485 LR 486
LR
Sbjct: 3672 LR 3673
Score = 57.4 bits (137), Expect = 3e-08
Identities = 86/465 (18%), Positives = 197/465 (42%), Gaps = 60/465 (12%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACE----GQHKLECDLQQRE 101
+ + KL +++ +Q E E L L+ + C + +L+ D+Q+R
Sbjct: 2084 QQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERN 2143
Query: 102 EEIAELQKALSDM-QVCLFQEREHV------------LRLYSENDRLRIRELEDKKKIQN 148
EEI +L+ + ++ Q L ++R+H ++L +E D + +E K+I N
Sbjct: 2144 EEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKE----KEITN 2199
Query: 149 LLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERK 208
L ++ F +E +K +Q+ + E ++ ES+ +E +
Sbjct: 2200 L-------EEQLEQFREELENKNEEVQQLHMQL-EIQKKESTT-----------RLQELE 2240
Query: 209 ESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKI 268
+ ++ ++ D++ L L ++ A + + + +I+++ + ++++ Q + Q ++
Sbjct: 2241 QENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQL 2300
Query: 269 KELTKN--LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKED 326
K T N + EL+ + L S+ + K N +I+Q +K +
Sbjct: 2301 KITTDNKVIEEKNELIRDLETQIECLMSDQE-------CVKRNREEEIEQLNEVIEKLQQ 2353
Query: 327 KIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRRE 386
++ + + H+ SE SLK +L ++ + ++LE+++ EE +
Sbjct: 2354 ELANIGQKTSMNAHSLSEEADSLKHQL-------DVVIAEKLALEQQVETANEEMTFMKN 2406
Query: 387 IFKD---RTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATV 443
+ K+ + N++ + L + + E++E+ + + I L + +LE +L + +
Sbjct: 2407 VLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDAL 2466
Query: 444 NARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488
+ NQ E + ++ L L+S V + EL C
Sbjct: 2467 KSLENQTYFKSFE-ENGKGSIINLETRLLQLESTVSAKDLELTQC 2510
Score = 57.0 bits (136), Expect = 4e-08
Identities = 102/520 (19%), Positives = 216/520 (41%), Gaps = 109/520 (20%)
Query: 59 LEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD-------LQQREEEIAELQKAL 111
+E QK+ + D+++++E + Q + E D +Q ++E I + +
Sbjct: 401 VEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQM 460
Query: 112 SDMQVCLFQEREHVLRLYSE----NDRLRIR---------ELED----KKKIQNLLALVG 154
+M+ E E+ LR YS D++++ +L+D K+K++ L L+
Sbjct: 461 EEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLIL 520
Query: 155 TDAGEVTYFCKEPPHKVTI----LQKTIQAVGECEQSESSAFKA-----DPKISKRRPSR 205
+ + ++ +++ +Q+ Q + E E + A K+ D K S
Sbjct: 521 EEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASE 580
Query: 206 ERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------- 254
RKE ++ ++ +++E L+ + E E +E R L
Sbjct: 581 SRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKL 640
Query: 255 -EEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 313
E+++++H+ N K+K+ +H+ Q++ D LQ +E K ++ EKDNL++K
Sbjct: 641 KEDLEIEHRINIEKLKD-NLGIHYKQQI------DGLQ--NEMSQKIETMQFEKDNLITK 691
Query: 314 IKQYRVQCKKKED------------------KIGKVLPVMHESHHAQSEYIKSLKDKLVQ 355
Q ++ K +D ++ K + ++ + + + +++ ++
Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751
Query: 356 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRIL 415
+ L +E+ L+E+ A++ E I KD + L+I T + R++
Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAE----NSILKDEKKTLEDMLKIHT---PVSQEERLI 804
Query: 416 EVEGFKT---------DIKVLRQKLKDLEQMLYK--------------ATVNARAN---- 448
++ K+ +I++L ++ +DL+Q + A N N
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Query: 449 -QDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRL 487
++ A L +V+D + K + EL+ KSK+ L EL L
Sbjct: 865 QEEYACLLKVKD-DLEDSKNKQELE-YKSKLKALNEELHL 902
Score = 52.8 bits (125), Expect = 7e-07
Identities = 100/510 (19%), Positives = 203/510 (39%), Gaps = 99/510 (19%)
Query: 51 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYK----EACEGQHKLECDLQQREEEIAE 106
+L LLE YQKK + + L +K+++Y+ + E +K E +Q++E I E
Sbjct: 276 QLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEE--IQEKETIIEE 333
Query: 107 L---------------------QKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKK 145
L K L ++Q + Q+ + + + E + +E + ++
Sbjct: 334 LNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEE 393
Query: 146 IQNLLALVGT-----------DAGEVTYFCKEPPHKVTILQKTI-----QAVGECEQSES 189
I+ L+ V + V +E K+ L+ + Q + + +Q
Sbjct: 394 IKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELI 453
Query: 190 SAFKADPKISKRRPSRERKESSEHYQR--------------------DIQTLILQVEALQ 229
A + K R E + + Y +Q Q E L+
Sbjct: 454 RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLK 513
Query: 230 AQLG---EQTKLSREQIEGLIEDRRIHLEEIQVQHQ---RNQNKIKELTKNLHHTQELLY 283
+LG E+ + Q+E L+E+ E+IQ Q ++K+ E K+L ++L
Sbjct: 514 EELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKA 573
Query: 284 ESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQS 343
E + R E + K + +++ Y+++ + E + VL M ES A+
Sbjct: 574 EIV-SASESRKELELKHE----------AEVTNYKIKLEMLEKEKNAVLDRMAESQEAEL 622
Query: 344 EYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMR-REIFKDRTNKMGKRLQIM 402
E +++ + E++LS + ++ I + ++++ G+ ++ N+M ++++ M
Sbjct: 623 ERLRT-QLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETM 681
Query: 403 TKRYEAL---ERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEV-- 457
+ L + + ILE+ KLKDL+Q L + Q L E+
Sbjct: 682 QFEKDNLITKQNQLILEI-----------SKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
Query: 458 -RDSNRRAHKIQGELKNLKSKVFGLENELR 486
R + ++ E++ L+ K LE +++
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
Score = 51.6 bits (122), Expect = 2e-06
Identities = 88/410 (21%), Positives = 186/410 (45%), Gaps = 63/410 (15%)
Query: 56 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQ 115
+ LL Q A+ L ++ E K + Q LE ++QQ++ ++ E+Q LS M
Sbjct: 3080 RSLLSEIQALHAQMNGRKITLKREQESEKPS---QELLEYNIQQKQSQMLEMQVELSSM- 3135
Query: 116 VCLFQEREHVLRLYSENDRLRIREL-----EDKKKIQNLLALVGTDAGEVTYF---CKEP 167
++R L+ ++++ + EL + K +++ L E+ F K+
Sbjct: 3136 ----KDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDK 3191
Query: 168 PHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER-KESSEHYQRDIQT---LIL 223
+V +L T+ E ++S + + + +K S ER KE E + +++ L
Sbjct: 3192 TDEVHLLNDTL--ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL 3249
Query: 224 QVEALQAQLGEQTKLSREQIEG--LIEDRRIHLE-----EIQVQHQRNQNKIKELTKNLH 276
Q+ L Q + S+++IE ++ D ++ E E+QV + + +I+E++ L
Sbjct: 3250 QLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLD 3309
Query: 277 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 336
+EL QL+S + + L ++L+ +++ K+ E+K +++ +++
Sbjct: 3310 REREL-------HAQLQSSDGTGQSRPPLPSEDLLKELQ------KQLEEKHSRIVELLN 3356
Query: 337 ESHHAQSEYIKSL----KDKLVQEKKLSNMYQ---------EQCISLEEELARIREEEGM 383
E+ + + +++ KD+ V K L + + S E+L R EE+
Sbjct: 3357 ETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEK-- 3414
Query: 384 RREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 433
R++++K + G+RLQ + + ++ E LE E + ++L Q L +
Sbjct: 3415 RQQVYK--LDLEGQRLQGIMQEFQKQE----LEREEKRESRRILYQNLNE 3458
Score = 44.7 bits (104), Expect = 2e-04
Identities = 100/489 (20%), Positives = 196/489 (40%), Gaps = 86/489 (17%)
Query: 54 PSKELLEYYQKKMAECEAENEDLLKKLELYK-EACEGQHKLECDLQ------QREEE--- 103
PS++LL+ QK++ E + +LL + E YK ++ + + ++E D Q Q E+E
Sbjct: 3332 PSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANT 3391
Query: 104 -----IAELQKALSDMQVCLFQEREHVLRLYSENDRL-------RIRELEDKKKIQNLLA 151
+ ELQ + D+Q L ++R+ V +L E RL + +ELE ++K ++
Sbjct: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI 3451
Query: 152 LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSE----------------------- 188
L T+ + +LQ+ I+ GE ++S
Sbjct: 3452 LYQNLNEPTTWSLTSDRTRNWVLQQKIE--GETKESNYAKLIEMNGGGTGCNHELEMIRQ 3509
Query: 189 -----SSAFKADPKISKRRPSRERKESSEH--YQRDIQTLILQVEALQAQLGEQTKL-SR 240
+S + P+ + R E + + Q +I +ILQ++ L Q GE+ L S
Sbjct: 3510 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSP 3569
Query: 241 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 300
G + +R + Q+ I +LT+ + + ++ + + R ++
Sbjct: 3570 STSCGSLTERLLR------QNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRD 3623
Query: 301 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 360
S + +L + +KE + L + A++E K LK +L + L
Sbjct: 3624 NS---SRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYK-LKAELRNDSLL- 3678
Query: 361 NMYQEQCISLEEELARIREEEG--MRREIFKDRTNKMGKRLQIMTKRYEALERRRI---- 414
Q +S + E ++ G +R E F+ K L ++ ++ E +
Sbjct: 3679 -----QTLSPDSEHVTLKRIYGKYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLA 3733
Query: 415 -LEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELK- 472
+ + TD++V+ + K + V+ ++ L+ RR H++ G +
Sbjct: 3734 RMGGQPAFTDLEVITNRPKGFTRFRSAVRVSIAISRMKFLV-------RRWHRVTGSVSI 3786
Query: 473 NLKSKVFGL 481
N+ FGL
Sbjct: 3787 NINRDGFGL 3795
Score = 40.8 bits (94), Expect = 0.003
Identities = 89/391 (22%), Positives = 157/391 (40%), Gaps = 65/391 (16%)
Query: 37 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 96
L+ P + E L PS+ + QK++ ++E DL ++E + + D
Sbjct: 1072 LDHLPSVTKESSLRATQPSEN--DKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVD 1129
Query: 97 LQQREEEIAELQKALSDM-QVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLA 151
Q RE E KAL + + +F + E + L E ++ +E D+ K +LL
Sbjct: 1130 -QVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLI 1188
Query: 152 --LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPS--RER 207
L + E +YF + ++L + +CE + + IS+ ++
Sbjct: 1189 GKLQKAVSEECSYFLQT---LCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDY 1245
Query: 208 KESSEHYQRDIQTLILQVE-------ALQAQL----GEQT----------KLSREQIEGL 246
+ + +Q ++ TL+ +V LQ +L G+QT L +E+ E L
Sbjct: 1246 RYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFL 1305
Query: 247 -IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFL--QLRSENQNKEKSW 303
I + +LE+I V H+ + +++L K Q ES L QL+ QN E
Sbjct: 1306 SIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEI 1365
Query: 304 MLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS--------------- 348
+ L + + + V D + V+ ES ++ Y S
Sbjct: 1366 HCLQKRLQA-VSESTVPPSLPVDSV-----VITESDAQRTMYPGSCVKKNIDGTIEFSGE 1419
Query: 349 --LKDKLVQEKKLSNMYQEQCISLEEELARI 377
+K++ K L YQEQ LEEE+A++
Sbjct: 1420 FGVKEETNIVKLLEKQYQEQ---LEEEVAKV 1447
Score = 40.8 bits (94), Expect = 0.003
Identities = 67/315 (21%), Positives = 135/315 (42%), Gaps = 47/315 (14%)
Query: 90 QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNL 149
+ +L D+ I+EL+ + +M L E+E V + +N LE +KK+ L
Sbjct: 2586 EDELGSDISALTLRISELESQVVEMHTSLILEKEQV-EIAEKN------VLEKEKKLLEL 2638
Query: 150 LALV-GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQS----ESSAFKADPKISKRRPS 204
L+ G + + K P V +L+ T + E+S E A +A+ ++ +
Sbjct: 2639 QKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAE-SVATKAEL 2697
Query: 205 RERKESSEHYQRDIQTLILQVEALQ---AQLGEQTKLSREQIEGLIEDRRIHLEEIQVQH 261
KE +E Q ++ + +LQ +Q+ + ++E++ L ++ +E +VQ
Sbjct: 2698 ASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE-----DETEVQE 2752
Query: 262 QRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKD-----NLMSK--- 313
+ + L L + + T L++ S NQ + +L K+ NL S+
Sbjct: 2753 SKKACMFEPLPIKL---SKSIASQTDGTLKISSSNQTPQ---ILVKNAGIQINLQSECSS 2806
Query: 314 ------IKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQC 367
I Q+ + +K ++ + M H +++E +K VQ + +E+C
Sbjct: 2807 EEVTEIISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQ------LLKEEC 2860
Query: 368 ISLEEELARIREEEG 382
+L+ + +R +EG
Sbjct: 2861 GTLKAVIQCLRSKEG 2875
Score = 36.2 bits (82), Expect = 0.069
Identities = 61/334 (18%), Positives = 136/334 (40%), Gaps = 86/334 (25%)
Query: 225 VEALQAQL-GEQTKLSREQIEGLIEDRRI--------HLEEIQVQHQRNQNKIKELTKNL 275
+E ++++L G+Q ++ E++ +E+ R+ L+E + ++ I +LT NL
Sbjct: 157 LEMMESELAGKQHEI--EELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANL 214
Query: 276 HHTQELLYESTKDFLQLRSEN--------------------------------------- 296
+ E+ ++FL+L ++
Sbjct: 215 QQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQ 274
Query: 297 -------------QNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGK--------VLPVM 335
Q K++ + ++ L KIK Y ++ KK + K ++ +
Sbjct: 275 QQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEEL 334
Query: 336 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 395
+ + + LKDKL KL QEQ + +E+ ++ + K + +
Sbjct: 335 NTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMK----LELTNSKQKERQS 390
Query: 396 GKRLQIMTKRYEALERRRILEVEGFKTDI--KVLRQKLKDLEQMLYKATVNARANQDLAL 453
+ ++ + E L++R + + F+TDI ++ ++ + LEQ+ +A ++ Q +
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQ-FETDIVQRMEQETQRKLEQL--RAELDEMYGQQIV- 446
Query: 454 LCEVRDSNRRAHKIQGELKNLKSKVFG-LENELR 486
+++ R H Q ++ +K++ G +EN LR
Sbjct: 447 --QMKQELIRQHMAQ--MEEMKTRHKGEMENALR 476
Score = 30.0 bits (66), Expect = 5.0
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 15/76 (19%)
Query: 74 EDLLKKLEL--YKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSE 131
E + K EL YKE E KL+ +L +E + LQK LS Q R+H L
Sbjct: 2689 ESVATKAELASYKEKAE---KLQEELLVKETNMTSLQKDLS-------QVRDH---LAEA 2735
Query: 132 NDRLRIRELEDKKKIQ 147
++L I E ED+ ++Q
Sbjct: 2736 KEKLSILEKEDETEVQ 2751
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 63.5 bits (153), Expect = 4e-10
Identities = 117/513 (22%), Positives = 221/513 (43%), Gaps = 71/513 (13%)
Query: 21 GVAVSGPTKRRGMADSLESTPLPSPE---DRLAKLHPSKELLEYYQKKMAECEAENEDLL 77
G A+S K R A L+ L S + D K S+ LL+ QK E +A + +LL
Sbjct: 1438 GDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQK---EVQALSTELL 1494
Query: 78 KKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSEND---R 134
K Y+E+ GQ L + + +EEI+ L + + L E E V +L E +
Sbjct: 1495 KLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNL-TEMEKVKKLIEEEKTEVQ 1553
Query: 135 LRIRELE-----DKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSES 189
+ + E E ++ KI + + E+ E ++ ++ Q + QS
Sbjct: 1554 VTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSL 1613
Query: 190 SAFKADPKISKRRPSRERKESSEHYQ--------------RDIQTLILQVEALQAQLGEQ 235
+ +A +I R ++ +E + + + L +Q++ LQ QL +
Sbjct: 1614 DS-EAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDS 1672
Query: 236 TKLS---REQI----------EGLIEDRRIHLEEIQVQHQRNQNKIKELTK--NLHHTQE 280
T+L+ +EQ+ + +ED R E+ + + ++ ++ E T+ NL +TQ
Sbjct: 1673 TQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQN 1732
Query: 281 LLYESTKDFLQLRSENQNKEKSWMLEK-DNLMSKIKQYRVQC-------KKKEDKIGKVL 332
S K L+ KE ++++ N K K+ ++ KKK+D I
Sbjct: 1733 TSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAH-- 1790
Query: 333 PVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG-MRREIFKDR 391
+ + + I L+ +L + ++++ M + I E +R+RE EG + EI +
Sbjct: 1791 --LERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLE--SRVRELEGELEGEIRRSA 1846
Query: 392 TNKMG-KRLQIMTKR--YEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARAN 448
+ G +RL+ K Y+A E ++ + +T + L+ K+++ +Q + A +AN
Sbjct: 1847 EAQRGARRLERCIKELTYQAEEDKK--NLSRMQTQMDKLQLKVQNYKQQVEVA--ETQAN 1902
Query: 449 QDLALL----CEVRDSNRRAHKIQGELKNLKSK 477
Q L+ E+ + RA + ++ LK K
Sbjct: 1903 QYLSKYKKQQHELNEVKERAEVAESQVNKLKIK 1935
Score = 52.0 bits (123), Expect = 1e-06
Identities = 90/429 (20%), Positives = 178/429 (41%), Gaps = 56/429 (13%)
Query: 35 DSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLE 94
D LE+ + S +++ H K L E E E NED+ K K E +
Sbjct: 967 DDLETMLVKSEKEKRTTEHKVKNLTE-------EVEFLNEDISKLNRAAKVVQEAHQQTL 1019
Query: 95 CDLQQREEEIAELQKA-------LSDMQVCLFQER------EHVLRLYSENDRLRIRELE 141
DL EE+++ L KA + +++ L QER E L N +L +E
Sbjct: 1020 DDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESME 1079
Query: 142 DKKKIQNLLA----LVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPK 197
+ + Q LA + ++ + V LQKT++ + + +A+ +
Sbjct: 1080 NLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAE-R 1138
Query: 198 ISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGL---IEDRRIHL 254
++ + RER + ++ D+ + +V E TK + + L +E+ +H
Sbjct: 1139 TTRAKMERERADLTQDL-ADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHF 1197
Query: 255 EEIQVQ-HQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSK 313
E +R+ + + EL + + Q++ + KD L+ LE D+L+++
Sbjct: 1198 ETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQ-----------LEVDDLLTR 1246
Query: 314 IKQYRVQCKKKEDKIGKVLPV-MHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEE 372
++Q + K +K+ + +HE+ + + D Q+ KL + E LEE
Sbjct: 1247 VEQ-MTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEE 1305
Query: 373 ELARI----REEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLR 428
+ A I RE+ R+I +D ++ K + + AL++ + D +LR
Sbjct: 1306 KEALINQLSREKSNFTRQI-EDLRGQLEKETKSQSALAHALQKA--------QRDCDLLR 1356
Query: 429 QKLKDLEQM 437
++ ++ +++
Sbjct: 1357 EQYEEEQEV 1365
Score = 32.7 bits (73), Expect = 0.76
Identities = 56/298 (18%), Positives = 122/298 (40%), Gaps = 40/298 (13%)
Query: 175 QKTIQAVGE-CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLG 233
Q+T+ V E CE S + + ++ + ER E E ++ ++E
Sbjct: 907 QETLANVEEQCEWLIKSKIQLEARVKELS---ERVEEEEEINSELTARGRKLE------D 957
Query: 234 EQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLR 293
E +L +E I+D L + + + + ++K+K LT+ + E + + + ++
Sbjct: 958 ECFELKKE-----IDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQ 1012
Query: 294 SENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL 353
+Q +E++ L S + +++ + + L+ L
Sbjct: 1013 EAHQQTLDDLHMEEEKLSS----------------------LSKANLKLEQQVDELEGAL 1050
Query: 354 VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRR 413
QE+K + + LE L RE + ++ K+ +++ +E +
Sbjct: 1051 EQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEK 1110
Query: 414 ILEVEGFKTDIKVLRQKLKDLEQML-YKATVNARANQDLA-LLCEVRDSNRRAHKIQG 469
L + KT +K L+ ++KDL++ L + T A+ ++ A L ++ D N R ++ G
Sbjct: 1111 GLVAQLQKT-VKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGG 1167
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 63.5 bits (153), Expect = 4e-10
Identities = 93/456 (20%), Positives = 205/456 (44%), Gaps = 61/456 (13%)
Query: 52 LHPSKELLEYYQKKMAECEAENEDLLKKLEL-YKEACEGQHKLECDLQQREEEIAELQKA 110
L + L+ K++ E E+ LK KE E ++L +L ++E EI+ +QK
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 111 LSDMQVCLFQEREHVLRLYSENDRLRIREL--------------EDKKKIQNLLALVGTD 156
L + L + + +Y + ++ I+++ E +K + L + +
Sbjct: 1514 LEAINDKL---QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK 1570
Query: 157 AGEVTYFCKEPPHKVTIL---QKTIQAVGECEQSESSAFKADPK--ISKRRPSRERKESS 211
E+T +E ++ I+ ++ ++ V E Q E K + K ++K + S+E++
Sbjct: 1571 MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE--- 1627
Query: 212 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 271
YQ T + + + ++ E ++ E ++++LE I+ ++ R L
Sbjct: 1628 --YQFLKMTAVNETQEKMCEI--------EHLKEQFETQKLNLENIETENIR-------L 1670
Query: 272 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 331
T+ LH E + TK+ R + ++ E++ +E+D L +++ + +K+++
Sbjct: 1671 TQILHENLEEMRSVTKE----RDDLRSVEETLKVERDQLKENLRETITRDLEKQEE---- 1722
Query: 332 LPVMHESHHAQSEYIKSLKDKLVQEK--KLSNMYQE---QCISLEEELARIREEEGMRRE 386
L ++H E I L+ +V EK ++SNM ++ +L+ + +I+EE +
Sbjct: 1723 LKIVHMHLKEHQETIDKLRG-IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHM 1781
Query: 387 IFKDRTNKMGKRLQIMTKRYEALER-RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVN- 444
K++ + K I++++ + L ++ LE K K+ K + + + K VN
Sbjct: 1782 HLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNE 1841
Query: 445 --ARANQDLALLCEVRDSNRRAHKIQGELKNLKSKV 478
+ ++ L +++D + K++ E NL K+
Sbjct: 1842 TQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKL 1877
Score = 60.8 bits (146), Expect = 3e-09
Identities = 102/495 (20%), Positives = 210/495 (42%), Gaps = 76/495 (15%)
Query: 37 LESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECD 96
L+ T + ++++ ++ KE E + + E EN L + L E K D
Sbjct: 1631 LKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD 1690
Query: 97 LQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIREL---EDKKKIQNLLALV 153
L+ EE + + L + RE + R + + L+I + E ++ I L +V
Sbjct: 1691 LRSVEETLKVERDQLKE------NLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 154 GTDAGEVTYFCKEPPHKVTILQ-KTIQAVGECEQSESSAFKADPKISKRRP-SRERKESS 211
E++ K+ H L+ + ++ E + + I K R E+ +
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKL 1804
Query: 212 EHYQRD-------IQTLILQVEALQAQL--------GEQTKLSR-EQIEGLIEDRRIHLE 255
+ Q+D +Q I +++A + QL Q K+S EQ++ I+D+ + L
Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLS 1864
Query: 256 EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNL----- 310
+++++ N N ++L +NL E K ++ R + E++ LE+D L
Sbjct: 1865 KLEIE---NLNLAQKLHENL--------EEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
Query: 311 ---------MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSL-KDKLVQEKKLS 360
++K R+ K+ ++ + K+ + E S+ K L K K +KK+
Sbjct: 1914 ETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ 1973
Query: 361 NMYQE--QCISLEEEL----ARIREEEGMRREIFKDRTNKMGKRL---QIMTKRYEALER 411
+ ++ Q + ++E++ +I E E ++++ + R+ Q+ K +E+LE
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033
Query: 412 RRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGEL 471
RI+ E + +++ +++ LK +Q +A L E+ +R+ H+++ E
Sbjct: 2034 IRIVAKE--RDELRRIKESLK------------MERDQFIATLREMIARDRQNHQVKPEK 2079
Query: 472 KNLKSKVFGLENELR 486
+ L L LR
Sbjct: 2080 RLLSDGQQHLTESLR 2094
Score = 58.9 bits (141), Expect = 1e-08
Identities = 98/506 (19%), Positives = 205/506 (40%), Gaps = 80/506 (15%)
Query: 57 ELLEYYQKKMAECEAENE--DLLKKLELYKEACEGQHKLECDLQ-QREEEIAELQKALSD 113
E++E +K + + +NE +L+ + KE + K ++ + +EE+ L L
Sbjct: 1037 EIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKK 1096
Query: 114 MQVCLFQEREHVLRLYSENDRL--RIRELEDKKK---------------IQNLLALVGTD 156
Q + QE+ H ++ E R R+ E+E+K K +Q ++ +
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK 1156
Query: 157 AGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQR 216
E+ E +K L+ E Q + ++ I+K R + + S +R
Sbjct: 1157 INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETER 1216
Query: 217 D-IQTLILQVEALQAQLGEQTKLS----REQIEGLIEDRR---------IHLEEIQVQHQ 262
D ++ I ++EA Q E+ K++ +E E + E RR I+ ++++ H
Sbjct: 1217 DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276
Query: 263 RNQNKIKEL---------TKNLHHTQELLYE--------STKDFLQLR------------ 293
+ Q +I L K + TQE + E +TKD L
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK 1336
Query: 294 -SENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLK-- 350
E+Q + KS E+DNL + + V+ + ++ I + L + ES Q + + +
Sbjct: 1337 FQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD 1396
Query: 351 ---DKLVQEKKLSNMYQEQCISLEEEL----ARIREEEGMRREIFKDRTNKMGKRLQIMT 403
K+V E + + +E E+ R++E + + K++ + + + +
Sbjct: 1397 NETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQS 1456
Query: 404 KRYEALERRRILEVEGFKT--DIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSN 461
+ + E + + + +T ++KV LK+ E+ + + VN + E+
Sbjct: 1457 ESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE-----TEISTIQ 1511
Query: 462 RRAHKIQGELKNLKSKVFGLENELRL 487
++ I +L+N +++ E + +
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNI 1537
Score = 48.5 bits (114), Expect = 1e-05
Identities = 97/502 (19%), Positives = 199/502 (39%), Gaps = 101/502 (20%)
Query: 63 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI------------------ 104
++KM E + + ++LY+ E + K++ DL++ +
Sbjct: 652 KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711
Query: 105 ----AELQKALSDMQVCLFQE-------REHVL------RLYSENDRLRIRELEDKKKIQ 147
EL+ ++D+Q L +E RE V+ L SE +RLR +E++DK +
Sbjct: 712 LLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR-KEIQDKSEEL 770
Query: 148 NLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQ----SESSAFKADPKISKRRP 203
+++ E E HK + +Q ++ +G+ + ++S+ D + +
Sbjct: 771 HII------TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
Query: 204 SR---ERK-----ESSEHYQRDIQTLILQVEALQAQLGE-QTKLSREQIE-----GLIED 249
E+K E +E ++I L + + + LG +T+LS + E +++
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 250 RRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL---YESTKDFLQLRSENQNKEKSWMLE 306
R +E+++ Q + + ++ + + E L E K Q + + + ++S +E
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944
Query: 307 KDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQ 366
+D L S I ++++ L ES E I +LK K+ +E +
Sbjct: 945 RDQLKSDIHDTVNMNIDTQEQLRNAL----ESLKQHQETINTLKSKISEEVSRN------ 994
Query: 367 CISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT---KRYEALERRR---------- 413
+ +EE ++E + + + K Q +T K E +E++R
Sbjct: 995 -LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKN 1053
Query: 414 ---------ILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRA 464
I E E KTD+K + + ++ L + Q++ V A
Sbjct: 1054 ELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI-----VAQEKNHA 1108
Query: 465 HKIQGELKNLKSKVFGLENELR 486
K +GEL ++ +E +L+
Sbjct: 1109 IKKEGELSRTCDRLAEVEEKLK 1130
Score = 45.1 bits (105), Expect = 1e-04
Identities = 76/411 (18%), Positives = 180/411 (43%), Gaps = 36/411 (8%)
Query: 51 KLHPSKELLEYYQKKMAECEAEN----EDLLKKLELYKEACEGQHKLECDLQQREEEIAE 106
++ P K LL Q+ + E E ++LLK+ + E ++L DL++ E E
Sbjct: 2074 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE 2133
Query: 107 LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKE 166
L + + + +H+ +L++ N R + KK++ +L+ V KE
Sbjct: 2134 LSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTK--------IKE 2185
Query: 167 PPHKVTILQKTIQAVGECEQSESSAFKADP-KISKRRPSRERKESSEHYQRDIQTLILQV 225
H+ +I + + + E E+ + K + PSRE ++ + D+ +
Sbjct: 2186 EQHE-SINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK 2244
Query: 226 EALQAQLG------EQTKLSREQIEGLIED---RRIHLEEIQVQHQRNQNKIKELTKNLH 276
+ +++ +Q +R+++ +E+ R +E+++ Q+ ++I ++ +
Sbjct: 2245 DFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFN 2304
Query: 277 HTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 336
+ + + +F + RS +KE W + +L K ++ + + + V
Sbjct: 2305 NRIIAIMNESTEF-EERSATISKE--WEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNP 2361
Query: 337 ESHHAQSEYIKSLKDKLVQEK--KLSNMY---QEQCISLEEELARIREEEGMRREI---F 388
+ ++ ++ S +L EK +L N +E + E ++ ++++E + +I
Sbjct: 2362 TTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421
Query: 389 KDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLK--DLEQM 437
+ + ++ K L+ + + L+ + L + +K +I+ L+ KL DLE+M
Sbjct: 2422 QAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKM 2472
Score = 44.7 bits (104), Expect = 2e-04
Identities = 69/386 (17%), Positives = 165/386 (42%), Gaps = 43/386 (11%)
Query: 56 KELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-LQKALSDM 114
K L Y +++ E E ++ L ++E KE E + +++ + I E LQ+ L ++
Sbjct: 865 KTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEV 924
Query: 115 QVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTIL 174
+ L QE++ + +L + L+I + K I + + + +
Sbjct: 925 KT-LTQEKDDLKQL---QESLQIERDQLKSDIHDTVNM-----------------NIDTQ 963
Query: 175 QKTIQAVGECEQSESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQAQLG 233
++ A+ +Q + + KIS+ + +E++ + + Q ++ ++ Q
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1023
Query: 234 EQTKLSREQIEG--LIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 291
+ T+ ++ +IE +R IQ +N+++++ +++ +E L K+ ++
Sbjct: 1024 KNTQTLTADVKDNEIIEQQRKIFSLIQ-----EKNELQQMLESVIAEKEQLKTDLKENIE 1078
Query: 292 LRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKD 351
+ ENQ + + E + Q + KKE ++ + + E E + L++
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138
Query: 352 KLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALER 411
K Q+Q ++++EE++ ++++ + + NK + T+R E ++
Sbjct: 1139 K-----------QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQK 1187
Query: 412 --RRILEVEGFKTDIKVLRQKLKDLE 435
EV+ + KVL++ K E
Sbjct: 1188 LNENYEEVKSITKERKVLKELQKSFE 1213
Score = 39.7 bits (91), Expect = 0.006
Identities = 84/439 (19%), Positives = 185/439 (42%), Gaps = 52/439 (11%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI- 104
++RL ++ KE LE + E E + +KL+ E + + + DL+Q +E +
Sbjct: 883 QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942
Query: 105 AELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFC 164
E + SD+ + + +L + + L+ + ++ I L + + + +
Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLK----QHQETINTLKSKISEEVSRNLHME 998
Query: 165 KEPPHKVTILQKTIQAVG---ECEQSESSAFKADPK----ISKRRPSRERKESSEHYQRD 217
+ Q+ + + + E + AD K I ++R + Q+
Sbjct: 999 ENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQM 1058
Query: 218 IQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHH 277
++++I + E L+ L +E IE IE NQ +++ L L
Sbjct: 1059 LESVIAEKEQLKTDL-------KENIEMTIE---------------NQEELRLLGDELKK 1096
Query: 278 TQELLYESTKDFLQLRSE-NQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 336
QE++ + ++ E ++ ++ +E+ K+K+ Q ++K+ ++ V M
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEE-----KLKEKSQQLQEKQQQLLNVQEEMS 1151
Query: 337 ESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMG 396
E +E I++LK++L ++ + + + L ++L EE + I K+R K+
Sbjct: 1152 EMQKKINE-IENLKNELKNKELTLEHMETERLELAQKLNENYEEV---KSITKER--KVL 1205
Query: 397 KRLQ--IMTKRYEALERRRILEVEGFKT--DIKVLRQKLKDLEQMLYKATVNARANQDLA 452
K LQ T+R R +E G +T ++K+ LK+ ++ + + + ++ A
Sbjct: 1206 KELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE--LRRSVSEKTA 1263
Query: 453 LLCEVRDSNRRAHKIQGEL 471
+ +D + K+Q E+
Sbjct: 1264 QIINTQDLEKSHTKLQEEI 1282
>gi|8922940 gamma-taxilin [Homo sapiens]
Length = 528
Score = 63.5 bits (153), Expect = 4e-10
Identities = 91/409 (22%), Positives = 175/409 (42%), Gaps = 57/409 (13%)
Query: 67 AECEAENEDLLKKLELYKEACEGQHKLECDLQQRE---EEIAELQKALSDMQVCLFQERE 123
A C E+ + + E + +GQ EC+ + + +E+ L +AL+ + E
Sbjct: 99 AYCTQESREEIPGGEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQALNTLST----PEE 154
Query: 124 HVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGE 183
+ L + L LE+ + +Q + ++ ++ KE H + K I A +
Sbjct: 155 KLAALCKKYADL----LEESRSVQKQMKILQKKQAQIV---KEKVHLQSEHSKAILARSK 207
Query: 184 CE------QSESSAFKADPKISKRRPSRERKESSEHYQ---RDIQTLILQVEALQAQLGE 234
E Q + K + R RKE++ H+Q +IQ + Q + A+L +
Sbjct: 208 LESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQ 267
Query: 235 QTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRS 294
+ E+++ LIE + E I +R + + + + L T +L+ E+
Sbjct: 268 ENIELGEKLKKLIEQYALREEHIDKVFKRKELQQQLVDAKLQQTTQLIKEA--------D 319
Query: 295 ENQNKEKSWML----EKDNLMSKIKQYRVQCKKK----EDKIGKVLPVMHESHHAQSEYI 346
E +E+ ++L E + ++KQ VQ K++ DK + M +S+ + +
Sbjct: 320 EKHQREREFLLKEATESRHKYEQMKQQEVQLKQQLSLYMDKFEEFQTTMAKSNELFTTFR 379
Query: 347 KSLKDKLVQEKKLSN---MYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMT 403
+ ++ + KKL +++ + + + L ++ EE+ +R +K K LQI
Sbjct: 380 QEMEKMTKKIKKLEKETIIWRTKWENNNKALLQMAEEKTVR--------DKEYKALQIKL 431
Query: 404 KRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLA 452
+R E L R E ++VL+ EQ+ KA + A AN+DLA
Sbjct: 432 ERLEKLCRALQTERNELNEKVEVLK------EQVSIKAAIKA-ANRDLA 473
Score = 35.8 bits (81), Expect = 0.090
Identities = 58/240 (24%), Positives = 105/240 (43%), Gaps = 29/240 (12%)
Query: 236 TKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSE 295
T+ SRE+I G + R + Q + N+NK K L K + + L +T + +
Sbjct: 102 TQESREEIPG--GEARTDPPDGQQDSECNRNKEKTLGKEVLLLMQAL--NTLSTPEEKLA 157
Query: 296 NQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQ 355
K+ + +LE+ + K Q ++ KK+ ++ E H QSE+ K++ +
Sbjct: 158 ALCKKYADLLEESRSVQK--QMKILQKKQAQ-------IVKEKVHLQSEHSKAILARSKL 208
Query: 356 EKKLSNMYQEQCISLEEELARIREEEGMRREI---FKDRTNKMGKRLQIMTKRYEALERR 412
E + + EE + + REEE R+E F+ +++ +L+ L +
Sbjct: 209 ESLCRELQRHNKTLKEENMQQAREEEERRKEATAHFQITLDEIQAQLEQHDIHNAKLRQE 268
Query: 413 RILEVEGFKTDIK--VLRQ-------KLKDLEQMLYKATVNARANQDLALLCEVRDSNRR 463
I E K I+ LR+ K K+L+Q L V+A+ Q L+ E + ++R
Sbjct: 269 NIELGEKLKKLIEQYALREEHIDKVFKRKELQQQL----VDAKLQQTTQLIKEADEKHQR 324
>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
[Homo sapiens]
Length = 1814
Score = 63.2 bits (152), Expect = 5e-10
Identities = 99/419 (23%), Positives = 177/419 (42%), Gaps = 65/419 (15%)
Query: 63 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA-------ELQKALSDMQ 115
++K E EA + K+ ++E + LE DL+++E EIA + KA+ +
Sbjct: 268 EEKERETEAAQMEHQKERNSFEERIQA---LEEDLREKEREIATEKKNSLKRDKAIQGLT 324
Query: 116 VCLFQEREHVLRLYSENDRL-----RIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 170
+ L + + V L SE ++L + RE K + Q G++ E KE
Sbjct: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ---GSEDYETALSGKEALSA 381
Query: 171 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRD-------IQTLI 222
Q ++ E + S K ++S + RER E E R+ I+ L
Sbjct: 382 ALRSQNLTKST-ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440
Query: 223 LQVEALQAQLGEQTKLSREQIEGLIED--RRIHLEEIQVQHQRNQNKIKELT------KN 274
+VE L+ ++ E+ K + + L+ + +++H +E ++H K++ K+
Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500
Query: 275 LHHTQELLYESTKDFLQLRSENQNKEK---------SWMLEKDNLMSKIKQYRVQCKKKE 325
L Q+ Y + L+LRSE EK + K+ S + +Q KKE
Sbjct: 501 LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560
Query: 326 DKIG----KVLPVMHESHHAQSEYIK--SLKDKLVQEKKLSNMYQEQCISLEEELARIRE 379
I K L ++ Q+E K +L+ +L Q+ YQ +LEE+++ IR
Sbjct: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRR 617
Query: 380 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 438
E ++ D+T+ + LE +VE F + L++K+ DL Q++
Sbjct: 618 REEESFSLYSDQTSYLS----------ICLEENNRFQVEHFSQE--ELKKKVSDLIQLV 664
Score = 43.1 bits (100), Expect = 6e-04
Identities = 74/341 (21%), Positives = 147/341 (43%), Gaps = 67/341 (19%)
Query: 200 KRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL---SREQIEGLIEDRRIHLEE 256
+ R +E +EH + L ++VE+L+ +L E+ +L + + +E L E ++
Sbjct: 85 EERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQR 144
Query: 257 IQVQHQRNQNKIKELT--------KNLHHTQELLYES-----TKDFLQLRSENQNKEKSW 303
++ ++ ++++L K++ Q L ++ T+ L+LR E++ E
Sbjct: 145 VKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK 204
Query: 304 MLEKDNLMS-----------------KIKQYRVQCKKKEDKIGKVLPVMHESH------- 339
M E D M+ K K+ +QC KE+K P + S
Sbjct: 205 MHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQC-LKEEKSQMACPDENVSSGELRGLC 263
Query: 340 -HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN--KMG 396
+ E + + ++ +K N ++E+ +LEE+L RE+E REI ++ N K
Sbjct: 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDL---REKE---REIATEKKNSLKRD 317
Query: 397 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA-TVNARANQDL---- 451
K +Q +T ++ E++ VE ++I+ L + L KA T + ++D
Sbjct: 318 KAIQGLTMALKSKEKK----VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETAL 373
Query: 452 ----ALLCEVRDSN----RRAHKIQGELKNLKSKVFGLENE 484
AL +R N H+++ +K + ++ L+ E
Sbjct: 374 SGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
Score = 34.3 bits (77), Expect = 0.26
Identities = 22/98 (22%), Positives = 49/98 (50%), Gaps = 17/98 (17%)
Query: 342 QSEYIKSLK------DKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 395
Q Y+K +K +++ + L N+ Q+ LEE+ ++++E+ + ++F + N
Sbjct: 1176 QVRYVKHVKILGPLAPEMIDSRVLENLKQQ----LEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
Query: 396 GKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 433
K + RY++L V+ ++ + RQ++KD
Sbjct: 1232 NKFRDLSPPRYDSL-------VQSQARELSLQRQQIKD 1262
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 63.2 bits (152), Expect = 5e-10
Identities = 99/419 (23%), Positives = 177/419 (42%), Gaps = 65/419 (15%)
Query: 63 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA-------ELQKALSDMQ 115
++K E EA + K+ ++E + LE DL+++E EIA + KA+ +
Sbjct: 268 EEKERETEAAQMEHQKERNSFEERIQA---LEEDLREKEREIATEKKNSLKRDKAIQGLT 324
Query: 116 VCLFQEREHVLRLYSENDRL-----RIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHK 170
+ L + + V L SE ++L + RE K + Q G++ E KE
Sbjct: 325 MALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQ---GSEDYETALSGKEALSA 381
Query: 171 VTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS-EHYQRD-------IQTLI 222
Q ++ E + S K ++S + RER E E R+ I+ L
Sbjct: 382 ALRSQNLTKST-ENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLR 440
Query: 223 LQVEALQAQLGEQTKLSREQIEGLIED--RRIHLEEIQVQHQRNQNKIKELT------KN 274
+VE L+ ++ E+ K + + L+ + +++H +E ++H K++ K+
Sbjct: 441 NEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKD 500
Query: 275 LHHTQELLYESTKDFLQLRSENQNKEK---------SWMLEKDNLMSKIKQYRVQCKKKE 325
L Q+ Y + L+LRSE EK + K+ S + +Q KKE
Sbjct: 501 LEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKE 560
Query: 326 DKIG----KVLPVMHESHHAQSEYIK--SLKDKLVQEKKLSNMYQEQCISLEEELARIRE 379
I K L ++ Q+E K +L+ +L Q+ YQ +LEE+++ IR
Sbjct: 561 QDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVL---SYQNLRKTLEEQISEIRR 617
Query: 380 EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 438
E ++ D+T+ + LE +VE F + L++K+ DL Q++
Sbjct: 618 REEESFSLYSDQTSYLS----------ICLEENNRFQVEHFSQE--ELKKKVSDLIQLV 664
Score = 43.1 bits (100), Expect = 6e-04
Identities = 74/341 (21%), Positives = 147/341 (43%), Gaps = 67/341 (19%)
Query: 200 KRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL---SREQIEGLIEDRRIHLEE 256
+ R +E +EH + L ++VE+L+ +L E+ +L + + +E L E ++
Sbjct: 85 EERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQR 144
Query: 257 IQVQHQRNQNKIKELT--------KNLHHTQELLYES-----TKDFLQLRSENQNKEKSW 303
++ ++ ++++L K++ Q L ++ T+ L+LR E++ E
Sbjct: 145 VKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSEMKK 204
Query: 304 MLEKDNLMS-----------------KIKQYRVQCKKKEDKIGKVLPVMHESH------- 339
M E D M+ K K+ +QC KE+K P + S
Sbjct: 205 MHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQC-LKEEKSQMACPDENVSSGELRGLC 263
Query: 340 -HAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTN--KMG 396
+ E + + ++ +K N ++E+ +LEE+L RE+E REI ++ N K
Sbjct: 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDL---REKE---REIATEKKNSLKRD 317
Query: 397 KRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKA-TVNARANQDL---- 451
K +Q +T ++ E++ VE ++I+ L + L KA T + ++D
Sbjct: 318 KAIQGLTMALKSKEKK----VEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETAL 373
Query: 452 ----ALLCEVRDSN----RRAHKIQGELKNLKSKVFGLENE 484
AL +R N H+++ +K + ++ L+ E
Sbjct: 374 SGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQE 414
Score = 37.7 bits (86), Expect = 0.024
Identities = 39/151 (25%), Positives = 75/151 (49%), Gaps = 18/151 (11%)
Query: 98 QQREEEIAELQKALSDMQVCLFQEREHVLRLYS----ENDRLRIRELEDKKKIQNLLALV 153
+ +++E +L+++LS V L EH+ R Y+ EN+RL+ E ++ Q L+ V
Sbjct: 1471 RDKQKENDKLRESLSRKTVSL----EHLQREYASVKEENERLQKEGSEKERHNQQLIQEV 1526
Query: 154 GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEH 213
E++ +E V + Q+ + + QS KA K+ + R R+ S E
Sbjct: 1527 RCSGQELSRVQEE----VKLRQQLLSQNDKLLQSLRVELKAYEKLDEEH-RRLREASGEG 1581
Query: 214 YQ-----RDIQTLILQVEALQAQLGEQTKLS 239
++ RD+ +L+++++AL+ QL + S
Sbjct: 1582 WKGQDPFRDLHSLLMEIQALRLQLERSIETS 1612
Score = 34.3 bits (77), Expect = 0.26
Identities = 22/98 (22%), Positives = 49/98 (50%), Gaps = 17/98 (17%)
Query: 342 QSEYIKSLK------DKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 395
Q Y+K +K +++ + L N+ Q+ LEE+ ++++E+ + ++F + N
Sbjct: 1176 QVRYVKHVKILGPLAPEMIDSRVLENLKQQ----LEEQEYKLQKEQNLNMQLFSEIHNLQ 1231
Query: 396 GKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKD 433
K + RY++L V+ ++ + RQ++KD
Sbjct: 1232 NKFRDLSPPRYDSL-------VQSQARELSLQRQQIKD 1262
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 62.8 bits (151), Expect = 7e-10
Identities = 107/526 (20%), Positives = 224/526 (42%), Gaps = 85/526 (16%)
Query: 12 RKRTVVSKRGVAVSGPTKRRGMADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEA 71
R + KR ++ + + D+L++T E R + EL + +++ EA
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ-ELRTKREQEVAELKKALEEETKNHEA 1192
Query: 72 ENEDLLKK----LELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQ---EREH 124
+ +D+ ++ LE E E + + +L++ ++ + K L+ L Q E EH
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEH 1252
Query: 125 --------VLRLY---SENDRLRIRELEDKKKIQNLLALVGTDAGEVTY----FCKEPPH 169
V L+ SE DRLR+ E K+QN L V T E F K+
Sbjct: 1253 KRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS 1312
Query: 170 KVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQ 229
+ LQ T + + E + + + ++ + + S + ++ E R + L QV ALQ
Sbjct: 1313 LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR--KNLEKQVLALQ 1370
Query: 230 AQLGEQTKL--------------------SREQIEGLIEDRRIHLEEIQVQHQRNQNKIK 269
+QL + K E + +E++ + ++++ R Q ++
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 270 ELTKNLHHTQEL---LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKED 326
+LT +L H +++ L + K F QL +E ++ + E+D + + ++KE
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD-------RAEAEAREKET 1483
Query: 327 KIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRRE 386
K + + E+ A+ E+ + Q K+L ++ S ++ + E E +R
Sbjct: 1484 KALSLARALEEALEAKEEFER-------QNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 387 IFKDRTNKMGKRLQIMTKRYEALERRRI-LEVE------GFKTDIKVLRQKLKDLEQMLY 439
+ + + +M +L+ + +A E ++ LEV F+ D++ ++ ++ +++L
Sbjct: 1537 L-EQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 440 KATVNARANQDLALLCEVRDSNRR-------AHKIQGELKNLKSKV 478
K Q L E+ D ++ K++ +LK+L++++
Sbjct: 1596 K--------QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633
Score = 56.2 bits (134), Expect = 6e-08
Identities = 93/462 (20%), Positives = 195/462 (42%), Gaps = 82/462 (17%)
Query: 64 KKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQERE 123
K + + + E+L K E + E Q K+E +L++ E + +L + + + L E E
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 124 HVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGE 183
L++E + +R R K++++ +L ++ +E + ILQ
Sbjct: 902 ----LFAEAEEMRARLAAKKQELEEIL-------HDLESRVEEEEERNQILQN------- 943
Query: 184 CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 243
E+ + A D E+ + E ++ +Q + EA ++ E+ L +Q
Sbjct: 944 -EKKKMQAHIQD--------LEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQN 994
Query: 244 EGLIEDRRI---HLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 300
I+++++ + E Q + K K L K + + QE++ ++ L+ + + +
Sbjct: 995 SKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK-IRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 301 KSWMLEKD-----------NLMSKIKQYRVQCKKKEDKIGKVL-----PVMHESHHAQ-- 342
+ + D L ++I + ++Q KKE+++ L +H+++ +
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 343 ---SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRL 399
I L++ EK N ++Q L EEL ++ E +D + +
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTE-------LEDTLDTTAAQQ 1166
Query: 400 QIMTKR-YEALERRRILEVE--GFKTDIKVLRQK----LKDLEQMLYKA---TVNARANQ 449
++ TKR E E ++ LE E + I+ +RQ+ L++L + L +A N N+
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226
Query: 450 ------DLALLCEVR-------DSNRRAHKIQGELKNLKSKV 478
+ L CEV+ +S + K+ +++ L +KV
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV 1268
Score = 53.5 bits (127), Expect = 4e-07
Identities = 98/467 (20%), Positives = 193/467 (41%), Gaps = 59/467 (12%)
Query: 63 QKKMAECEAENEDL--LKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDM--QVCL 118
++ AE EA ++ L +EA E + + E +Q ++ +L + D+ V
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1529
Query: 119 FQEREHVLRLYSENDRLRIRELEDKKKIQ---------NLLALVGTDAGEVTYFCKEPPH 169
++ + L E R ++ ELED+ + N+ A+ ++ ++
Sbjct: 1530 LEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEE 1589
Query: 170 KVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESS---EHYQRDIQTLILQVE 226
K +L K ++ + E E + +A SK++ + K+ E + +I Q+
Sbjct: 1590 KKRLLIKQVREL-EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR 1648
Query: 227 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL---- 282
LQAQ+ + RE +E+ R +EI Q + ++ K+K L + QE L
Sbjct: 1649 KLQAQMKDY---QRE-----LEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 283 -----YESTKDFLQLRSENQNKEKSWML-EKDNLMSKIKQYRVQCKKKEDKIGKVLPVMH 336
E +D L N KS +L EK L ++I Q + ++++ + +++
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSN----MELLN 1756
Query: 337 ESHHAQSEYIKSLKDKLVQEK----KLSNMYQEQCISLEEELARIREEEGMRREIFKDRT 392
+ + + +L +L E+ K N Q+ +E A+++E EG + FK
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATI 1816
Query: 393 NKMGKRLQIMTKRYE----------ALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKAT 442
+ + ++ + ++ E L RR +++ ++ R+ ++ + KA
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKA- 1875
Query: 443 VNARANQDLALLCEVRDSNRRAH----KIQGELKNLKSKVFGLENEL 485
NAR Q L E + RA+ K+Q EL + GL E+
Sbjct: 1876 -NARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREV 1921
Score = 53.1 bits (126), Expect = 5e-07
Identities = 79/374 (21%), Positives = 159/374 (42%), Gaps = 61/374 (16%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAEN---------EDLLKKLELYKEACE-GQHKLEC 95
EDR+A+ S +L E +K + N E+ LKK E ++ E + KL+
Sbjct: 1005 EDRIAEC--SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 96 DLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGT 155
+ +++IAELQ + ++++ L ++ E + + D + + K ++ L A
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA---- 1118
Query: 156 DAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQ 215
++ LQ+ + E ++S KA+ + KR S E + +
Sbjct: 1119 --------------QIAELQE------DFESEKASRNKAEKQ--KRDLSEELEALKTELE 1156
Query: 216 RDIQTLILQ----------VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQ 265
+ T Q V L+ L E+TK QI+ + + LEE+ Q ++ +
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 266 NKIKELTKN---LHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQ---YRV 319
L KN L + L K Q+++E+++K K + L +K+ + RV
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276
Query: 320 QCKKK----EDKIGKVLPVMHESHHAQSEYIK---SLKDKLVQEKKLSNMYQEQCISLEE 372
+ +K ++++ V ++ E+ ++ K SL+ +L ++L Q ++L
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336
Query: 373 ELARIREEEGMRRE 386
+ ++ EE+ +E
Sbjct: 1337 RIRQLEEEKNSLQE 1350
Score = 48.5 bits (114), Expect = 1e-05
Identities = 56/309 (18%), Positives = 132/309 (42%), Gaps = 29/309 (9%)
Query: 195 DPKISKRRPSRERKESS-EHYQRDIQTLILQVEALQAQLGEQTKL-------------SR 240
D ++ K + + + E E +R Q L+ + L QL +T+L +
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 241 EQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 300
+++E ++ D +EE + ++Q QN+ K++ ++ +E L E +
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL-----------DEEEGAR 966
Query: 301 KSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLS 360
+ LEK +KIK+ + ED+ K + +E L ++ + K L+
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 361 NMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGF 420
+ +Q + + + R+++EE R+E+ K + G+ + + E + L+++
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 421 KTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRD----SNRRAHKIQGELKNLKS 476
K + ++ + ++ L+K + A + E+++ +K + + ++L
Sbjct: 1087 KKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSE 1146
Query: 477 KVFGLENEL 485
++ L+ EL
Sbjct: 1147 ELEALKTEL 1155
Score = 44.3 bits (103), Expect = 3e-04
Identities = 48/260 (18%), Positives = 118/260 (45%), Gaps = 34/260 (13%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIA 105
++ + +L + ++ YQ+++ E A +++ + KE+ + LE ++ Q +EE+A
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS---KESEKKLKSLEAEILQLQEELA 1697
Query: 106 ELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTY--- 162
++A + QER+ + + + + L++K++++ +A + + E
Sbjct: 1698 SSERARRHAE----QERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1753
Query: 163 FCKEPPHKVTILQKTIQAVGECEQSESSAFKAD-PKISKRRPSRERKESSEHYQRDIQTL 221
+ K T+ T+ A E S+A K+D + R ++E K + + +++
Sbjct: 1754 LLNDRFRKTTLQVDTLNA--ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811
Query: 222 I-LQVEALQAQLGE--------------------QTKLSREQIEGLIEDRRIHLEEIQVQ 260
+ AL+A++G+ +T+ ++I +ED R H ++ + Q
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQ 1871
Query: 261 HQRNQNKIKELTKNLHHTQE 280
++ ++K+L + L +E
Sbjct: 1872 MEKANARMKQLKRQLEEAEE 1891
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 62.4 bits (150), Expect = 9e-10
Identities = 91/429 (21%), Positives = 183/429 (42%), Gaps = 70/429 (16%)
Query: 46 EDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLE--LYKEACEGQH------KLECDL 97
EDR+A+ + E K +A+ + ++E ++ LE L +E + Q KLE D
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 98 QQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDA 157
++IAELQ ++++++ L ++ E ++Q LA V +A
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEE---------------------ELQAALARVEEEA 1096
Query: 158 GEVTYFCKEPPHKVTILQKTIQAVGECEQSE-SSAFKADPKISKRRPSRERKESSEHYQR 216
+ K K+ L+ I + E +SE +S KA+ ++R E E+ +
Sbjct: 1097 AQKNMALK----KIRELESQISELQEDLESERASRNKAE---KQKRDLGEELEALKTELE 1149
Query: 217 DIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLH 276
D + L+++ ++ + ++ +E E+ + H +IQ Q++ ++EL + L
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLE---EEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 277 HTQEL-----------------LYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRV 319
T+ + L K LQ + ++++K K + L K +
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 320 QCKKKEDKIGK-------VLPVMHESHHAQSEYIK---SLKDKLVQEKKLSNMYQEQCIS 369
+ DK+ K V ++ +S S+ K +L+ +L ++L Q +S
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Query: 370 LEEELARIREEE-GMRREIFKDRTNKMGKRLQIMTKRYEALERRRILE--VEGFKTDIKV 426
L +L ++ +E+ R ++ ++ K QI T + + ++ +E V +T +V
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386
Query: 427 LRQKLKDLE 435
R+ KDLE
Sbjct: 1387 KRKLQKDLE 1395
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/292 (21%), Positives = 136/292 (46%), Gaps = 24/292 (8%)
Query: 205 RERKESSEHYQRDIQTLILQVEA----LQAQLGEQTKL--SREQIEGLIEDRRIHLEEIQ 258
RE++ ++E+ +++TL Q+ A LQ QL +T+L E++ + ++ LEEI
Sbjct: 858 REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEIC 917
Query: 259 VQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYR 318
+ + +E ++L ++ + ++ ++ + E ++ + LEK +K+K+
Sbjct: 918 HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLE 977
Query: 319 VQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEK---KLSNMYQEQCISLEEELA 375
+ ED+ K+ +E+ +L ++ + K KL N ++ LEE
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE--- 1034
Query: 376 RIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV-LRQKLKDL 434
R+R EE R+E+ K R G + +I E++ ++K+ L +K ++L
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSD---------QIAELQAQIAELKMQLAKKEEEL 1085
Query: 435 EQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELR 486
+ L A V A Q L ++R+ + ++Q +L++ ++ E + R
Sbjct: 1086 QAAL--ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135
Score = 53.5 bits (127), Expect = 4e-07
Identities = 107/473 (22%), Positives = 194/473 (41%), Gaps = 71/473 (15%)
Query: 63 QKKMAECEAENEDL--LKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDM--QVCL 118
++ AE EA ++ L +EA E + +LE +Q E+ +L + D+ V
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 119 FQEREHVLRLYSENDRLRIRELEDKKK------------IQNLLALVGTDAGEVTYFCKE 166
++ + L E + ++ ELED+ + +Q + A D +E
Sbjct: 1523 LEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582
Query: 167 PPHKVTILQKTIQAVGECEQSESS-AFKADPKISKRRPSRERKESSEHYQRDIQTLILQV 225
++ + ++A E E+ + S A A K+ E S + RD I Q+
Sbjct: 1583 KKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD--EAIKQL 1640
Query: 226 EALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYES 285
LQAQ+ + RE ++D R EEI Q + N+ K+K + + QE L +
Sbjct: 1641 RKLQAQMKD---CMRE-----LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692
Query: 286 TKDFLQLRSE----------NQNKEKSWMLEKDNLMSKIKQYRVQCKKKE-------DKI 328
+ Q + E + K + EK L ++I Q + ++++ D++
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752
Query: 329 GKV--------LPVMHESHHAQ---------SEYIKSLKDKLVQ-EKKLSNMYQEQCISL 370
K + E HAQ K LK KL + E + + Y+ +L
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812
Query: 371 EEELARIREE---EGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVL 427
E ++A++ E+ E R+ + + K+L+ + + + ERR E +K
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDD-ERR---NAEQYKDQADKA 1868
Query: 428 RQKLKDLEQMLYKATVNA-RANQD-LALLCEVRDSNRRAHKIQGELKNLKSKV 478
+LK L++ L +A A RAN L E+ D+ A + E+ +LK+K+
Sbjct: 1869 STRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 50.4 bits (119), Expect = 4e-06
Identities = 99/467 (21%), Positives = 203/467 (43%), Gaps = 65/467 (13%)
Query: 55 SKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-------- 106
++EL K E E DL ++E +E C+ + +QQ +E+ E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 107 -----LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 161
L+K ++ ++ +E + +L +N +L ++KK +++ +A E T
Sbjct: 959 RQKLQLEKVTTEAKLKKLEEEQIILE--DQNCKL----AKEKKLLEDRIA-------EFT 1005
Query: 162 YFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKE---SSEHYQRDI 218
E K L K +++ A D + RR ++R+E + + D
Sbjct: 1006 TNLTEEEEKSKSLAKL--------KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 219 QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHT 278
L Q+ LQAQ+ E K+ + E ++ +EE Q KI+EL +
Sbjct: 1058 TDLSDQIAELQAQIAE-LKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 279 QELLYESTKDFLQLRSENQNKEKSWMLE------KDNLMSKIKQYRVQCKKKEDK--IGK 330
QE L ++ + ++E Q ++ LE +D L S Q ++ K++++ + K
Sbjct: 1117 QEDL--ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174
Query: 331 VLPVMHESHHAQ--------SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEG 382
L ++H AQ S+ ++ L ++L Q K++ ++ +LE E + E
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
Query: 383 MRREIFKDRTNKMGK---RLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLY 439
+ + D +K K +LQ + ++ ER R E+ T ++V +L ++ +L
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR-TELADKVTKLQV---ELDNVTGLLS 1290
Query: 440 KA-TVNARANQDL-ALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 484
++ + +++ +D AL +++D+ + + +L +K+ +E+E
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337
Score = 29.3 bits (64), Expect = 8.5
Identities = 29/126 (23%), Positives = 56/126 (44%), Gaps = 21/126 (16%)
Query: 364 QEQCISLEEELARIREE----EGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 419
+E+ ++ EEEL ++RE+ E E+ ++ M ++LQ+ E L+ L E
Sbjct: 844 EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ----EQLQAETELCAEA 899
Query: 420 FKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVF 479
+ + L K ++LE++ + L V + R +Q E K ++ +
Sbjct: 900 EELRAR-LTAKKQELEEICHD------------LEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 480 GLENEL 485
LE +L
Sbjct: 947 ELEEQL 952
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 62.4 bits (150), Expect = 9e-10
Identities = 90/440 (20%), Positives = 181/440 (41%), Gaps = 54/440 (12%)
Query: 46 EDRLAKLHPSKELL-EYYQKKMAECEAENEDL------LKKLELYKEACEG--------- 89
++ +AKL K+ L E +Q+ + + +AE + + KLE + EG
Sbjct: 989 DETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLR 1048
Query: 90 ------QHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDK 143
+ KLE DL+ +E +++ + L ++ + L S+ + + E++ +
Sbjct: 1049 MDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQ 1108
Query: 144 KKIQNLLALV---GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISK 200
KKI+ L A + G + + + + L + ++ + E + A A +++K
Sbjct: 1109 KKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNK 1168
Query: 201 RRPSRERKESSEHYQRDIQTLILQVEAL-----------QAQLGEQTKLSREQIEGLIED 249
+R + +K +RD++ LQ EA+ A+LGEQ + ++++ +E
Sbjct: 1169 KREAEFQK-----LRRDLEEATLQHEAMVAALRKKHADSMAELGEQID-NLQRVKQKLEK 1222
Query: 250 RRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDN 309
+ L+ N I + NL L + + E Q ++
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRAR 1282
Query: 310 LMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCIS 369
L ++ +Y Q +K+ + + + S A ++ I+ LK +L +E K N S
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQ----LSRSKQASTQQIEELKHQLEEETKAKNALAHALQS 1338
Query: 370 LEEELARIR---EEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKV 426
+ +R EEE + + +K + +YE +R E+E K K
Sbjct: 1339 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK---KK 1395
Query: 427 LRQKLKDLEQMLYKATVNAR 446
L Q+L++ E+ + VNA+
Sbjct: 1396 LAQRLQEAEE--HVEAVNAK 1413
Score = 53.5 bits (127), Expect = 4e-07
Identities = 92/462 (19%), Positives = 191/462 (41%), Gaps = 65/462 (14%)
Query: 51 KLHPSKELLEYYQKKMAECEAENEDLLKKL-ELYKEACEGQ---HKLECDLQQREEEIAE 106
+L K + E ++ EN++L +++ +L ++ EG H+LE +Q E+E E
Sbjct: 1483 ELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCE 1542
Query: 107 LQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKE 166
+Q AL + + L E +LR+ E ++++ EV E
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVK---------------------SEVDRKIAE 1581
Query: 167 PPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVE 226
++ L++ V E QS D +I R + K+ E D+ + +Q+
Sbjct: 1582 KDEEIDQLKRNHTRVVETMQS-----TLDAEIRSRNDALRVKKKME---GDLNEMEIQLN 1633
Query: 227 ALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYEST 286
+L ++ + +G++++ ++HL++ R Q +KE + LL
Sbjct: 1634 HAN-RLAAESLRNYRNTQGILKETQLHLDDA----LRGQEDLKEQLAIVERRANLLQAEI 1688
Query: 287 KDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ-------CKKKEDKI----GKVLPVM 335
++ + + K E + +++ Q KK E+ + +V V+
Sbjct: 1689 EELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVI 1748
Query: 336 HESHHAQSEYIKSLKD------KLVQEKKLSNMYQEQCISLEEELA----RIREEEGMRR 385
ES +A+ + K++ D +L +E+ S + +LE+ + R+ E E +
Sbjct: 1749 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL 1808
Query: 386 EIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNA 445
+ K + K+ R++ + E ++R V+G + +++K+L + N
Sbjct: 1809 KGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH----ERRVKELTYQTEEDRKNV 1864
Query: 446 RANQDLA--LLCEVRDSNRRAHKIQGELKNLKSKVFGLENEL 485
QDL L +V+ R+A + + + SK L++EL
Sbjct: 1865 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL 1906
Score = 52.0 bits (123), Expect = 1e-06
Identities = 98/453 (21%), Positives = 190/453 (41%), Gaps = 50/453 (11%)
Query: 49 LAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-L 107
++K+ + + QKK+ E +A E+L +++E + + K DL + EEI+E L
Sbjct: 1094 ISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL 1153
Query: 108 QKA--LSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLL--ALVGTDAGEVTYF 163
++A + QV L ++RE +E +LR R+LE+ + AL A +
Sbjct: 1154 EEAGGATSAQVELNKKRE------AEFQKLR-RDLEEATLQHEAMVAALRKKHADSMAEL 1206
Query: 164 CKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRER------------KESS 211
++ + + QK + E + ISK + + E+ K
Sbjct: 1207 GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE 1266
Query: 212 EHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKEL 271
E QR I L Q LQ + GE ++ E+ + L+ + Q + +++++E
Sbjct: 1267 EEQQRLINDLTAQRARLQTEAGEYSRQLDEK-DALVSQLSRSKQASTQQIEELKHQLEEE 1325
Query: 272 TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKV 331
TK + L S D LR E +E+ E +SK Q + K
Sbjct: 1326 TKAKNALAHALQSSRHDCDLLR-EQYEEEQEGKAELQRALSKANSEVAQWRTK------- 1377
Query: 332 LPVMHESHHAQ-SEYIKSLKDKLVQEKKLSNMYQE----QCISLEEELARIREE-EGMRR 385
+E+ Q +E ++ K KL Q + + + E +C SLE+ R++ E E +
Sbjct: 1378 ----YETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433
Query: 386 EIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNA 445
++ +R+N L + ++ + + E + +++ +++ + L L+K V
Sbjct: 1434 DV--ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK--VKN 1489
Query: 446 RANQDLALLCEVRDSNRRAHKIQGELKNLKSKV 478
+ L L +R N+ +Q E+ +L ++
Sbjct: 1490 VYEESLDQLETLRRENK---NLQQEISDLTEQI 1519
Score = 46.6 bits (109), Expect = 5e-05
Identities = 80/421 (19%), Positives = 181/421 (42%), Gaps = 44/421 (10%)
Query: 65 KMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREH 124
K AE E E + ++ + K+ K E ++ EE++ L K +D+Q
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELA---KSEAKRKELEEKMVTLLKEKNDLQ--------- 891
Query: 125 VLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPH-KVTILQKTIQAVGE 183
L++ SE D L E ++ I+N + L EVT +E + K + E
Sbjct: 892 -LQVQSEADSLADAEERCEQLIKNKIQL-EAKIKEVTERAEEEEEINAELTAKKRKLEDE 949
Query: 184 CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 243
C + + + ++K + K ++E+ +++ + ++ A+L ++ K +E
Sbjct: 950 CSELKKDIDDLELTLAK---VEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH 1006
Query: 244 EGLIEDRRIHLEEIQV---QHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKE 300
+ ++D + +++ + + + ++ +L +L ++L + + +L + + +
Sbjct: 1007 QQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1066
Query: 301 KSWM-LEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKL 359
+S M +E D +Q + +KKE +I S I ++D+ E +L
Sbjct: 1067 ESTMDMENDK-----QQLDEKLEKKEFEI--------------SNLISKIEDEQAVEIQL 1107
Query: 360 SNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 419
+E +EE I E R + K R++ + + L+ +++R E +VE
Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSD-LSRELEEISERLEEAGGATSAQVEL 1166
Query: 420 FKTDIKVLRQKLKDLEQ--MLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSK 477
K ++ +DLE+ + ++A V A + + E+ + +++ +L+ KS+
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226
Query: 478 V 478
+
Sbjct: 1227 L 1227
Score = 45.8 bits (107), Expect = 9e-05
Identities = 70/340 (20%), Positives = 140/340 (41%), Gaps = 54/340 (15%)
Query: 184 CEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQI 243
CEQ + + + KI + ER E E ++ ++E E ++L ++
Sbjct: 908 CEQLIKNKIQLEAKIKE---VTERAEEEEEINAELTAKKRKLE------DECSELKKD-- 956
Query: 244 EGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSW 303
I+D + L +++ + +NK+K LT+ + E + + +K+ L+ +Q
Sbjct: 957 ---IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013
Query: 304 MLEKD--NLMSKI------------------KQYRVQCKKKEDKIGKVLPVMHESHHAQS 343
E+D N+++K K+ R+ ++ + K+ L + ES
Sbjct: 1014 QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME 1073
Query: 344 EYIKSLKDKLVQEKK-------LSNMYQEQCISLE-----EELARIREEEGMRREIFKDR 391
+ L +KL EKK +S + EQ + ++ +EL EE G E +
Sbjct: 1074 NDKQQLDEKL--EKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS 1131
Query: 392 TNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDL 451
K K+ +++ E + R LE G T +V K ++ E + + Q
Sbjct: 1132 RAKAEKQRSDLSRELEEISER--LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189
Query: 452 ALLCEVRDSNRRAHKIQGE----LKNLKSKVFGLENELRL 487
A++ +R + + GE L+ +K K+ ++EL++
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKM 1229
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 62.0 bits (149), Expect = 1e-09
Identities = 91/429 (21%), Positives = 193/429 (44%), Gaps = 46/429 (10%)
Query: 67 AECEAENEDLLKKLELYKEAC----EGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 122
A+ E + +DL LE K+ + KLE DL+ +E I +L+ ++ L ++
Sbjct: 1029 AKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKE 1088
Query: 123 EHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEV----TYFCKEPPHKVTILQKTI 178
+ +L ++ D ++ L+ +KKI+ L A + E+ T K + + L + +
Sbjct: 1089 FELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQR-SDLAREL 1147
Query: 179 QAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKL 238
+ + E + S A A +++K+R + +K +RD++ LQ EA A L ++
Sbjct: 1148 EEISERLEEASGATSAQIEMNKKREAEFQK-----MRRDLEEATLQHEATAATLRKKQAD 1202
Query: 239 S----REQIEGLIE-DRRIHLE--EIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 291
S EQI+ L +++ E E++++ + I+ L+K+ + + F +
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE 1262
Query: 292 LRSENQNKEK---SWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKS 348
++++++ + + ++K L ++ + + ++KE I + + +S A ++ ++
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQ----LTKSKQALTQQLEE 1318
Query: 349 LKDKLVQEKKLSNMYQEQCISLEEELARIR---EEEGMRREIFKDRTNKMGKRLQIMTKR 405
LK ++ +E K N S + +R EEE + + +K + +
Sbjct: 1319 LKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK 1378
Query: 406 YEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRAH 465
YE +R E+E K K L Q+L++ E+ AN A L +
Sbjct: 1379 YETDAIQRTEELEEAK---KKLAQRLQEAEEN------TETANSKCASL------EKTKQ 1423
Query: 466 KIQGELKNL 474
++QGE+++L
Sbjct: 1424 RLQGEVEDL 1432
Score = 53.1 bits (126), Expect = 5e-07
Identities = 82/446 (18%), Positives = 187/446 (41%), Gaps = 60/446 (13%)
Query: 38 ESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDL 97
E+ L E+R L SK LLE K++ E E E++ +L K
Sbjct: 898 ETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKK------------- 944
Query: 98 QQREEEIAELQKALSDMQVCL--FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGT 155
+ E++ + L++ + D+++ L ++ +H +EN K++NL +
Sbjct: 945 RNLEDKCSSLKRDIDDLELTLTKVEKEKHA----TEN------------KVKNLSEEMTA 988
Query: 156 DAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQ 215
++ KE Q+T+ + E + K + K+ ++ E E
Sbjct: 989 LEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE--- 1045
Query: 216 RDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNL 275
+ L +E + +L K+S+E I L D+ ++I+ + ++ + ++ +L +
Sbjct: 1046 ---KKLRADLERAKRKLEGDLKMSQESIMDLENDK----QQIEEKLKKKEFELSQLQAKI 1098
Query: 276 HHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVM 335
Q + K +L++ + E+ E L +KI++ R ++ ++I + L
Sbjct: 1099 DDEQVHSLQFQKKIKELQARIEELEEEIEAE-HTLRAKIEKQRSDLARELEEISERL--- 1154
Query: 336 HESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKM 395
E+ A S I+ K + + +K+ +E + E A +R+++ D ++
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA-------DSVAEL 1207
Query: 396 GKRLQIMTKRYEALERRRI---LEVEGFKTDIKVLRQKLKDLEQMLYK-----ATVNARA 447
G+++ + + + LE+ + +E++ ++I+ L + ++E+ + + A+
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 448 NQDLALLCEVRDSNRRAHKIQGELKN 473
Q L+ ++ R GEL +
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSH 1293
Score = 52.4 bits (124), Expect = 9e-07
Identities = 79/397 (19%), Positives = 166/397 (41%), Gaps = 38/397 (9%)
Query: 51 KLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKA 110
KL S+ LE QK E + + +L K Y+E + L + + +EEI++L +
Sbjct: 1463 KLDESQAELEAAQK---ESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519
Query: 111 LSDMQVCLFQEREHVLRLYSEND---RLRIRELE-----DKKKIQNLLALVGTDAGEVTY 162
+++ L QE E +L + ++ + E+E ++ KI + + E+
Sbjct: 1520 IAETGKNL-QEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDR 1578
Query: 163 FCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLI 222
E ++ L++ Q E QS D +I R + K+ E D+ +
Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQS-----VLDAEIRSRNDALRLKKKME---GDLNEME 1630
Query: 223 LQVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELL 282
+Q+ Q+ E K R ++G ++D ++HL++ R+ +KE + LL
Sbjct: 1631 IQLGHSNRQMAETQKHLR-TVQGQLKDSQLHLDDA----LRSNEDLKEQLAIVERRNGLL 1685
Query: 283 YESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQ 342
E + +++ + E++ L + L+ + ++ + I + + Q
Sbjct: 1686 LEELE---EMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742
Query: 343 SEYIKSLKDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIM 402
+E S+++ E+K + + EE +++E+ + +M K L+
Sbjct: 1743 AEVENSIQESRNAEEKAKKAITDAAMMAEE----LKKEQDTSAHL-----ERMKKNLEQT 1793
Query: 403 TKRYE-ALERRRILEVEGFKTDIKVLRQKLKDLEQML 438
K + L+ L ++G K I+ L ++++LE L
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830
Score = 48.5 bits (114), Expect = 1e-05
Identities = 98/477 (20%), Positives = 190/477 (39%), Gaps = 68/477 (14%)
Query: 62 YQKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAE-LQKA--LSDMQVCL 118
+QKK+ E +A E+L +++E K DL + EEI+E L++A + Q+ +
Sbjct: 1108 FQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEM 1167
Query: 119 FQEREHVLRLYSENDRLRIRELEDKKKIQNLLA--LVGTDAGEVTYFCKEPPHKVTILQK 176
++RE +E ++R R+LE+ A L A V ++ + + QK
Sbjct: 1168 NKKRE------AEFQKMR-RDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 177 TIQAVGECEQSESSAFKADPKISKRRPSRER------------KESSEHYQRDIQTLILQ 224
+ E + +SK + + ER K E + I L +Q
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280
Query: 225 VEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYE 284
LQ Q GE + E+ E LI + + Q + + +++E TK + L
Sbjct: 1281 KARLQTQNGELSHRVEEK-ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339
Query: 285 STKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 344
S D LR E +E+ E +SK Q + K + + E A+
Sbjct: 1340 SRHDCDLLR-EQYEEEQEAKAELQRALSKANSEVAQWRTKYET--DAIQRTEELEEAK-- 1394
Query: 345 YIKSLKDKLVQEKKLSNMYQEQCISLEEELARIR-EEEGMRREI---------------- 387
K L +L + ++ + +C SLE+ R++ E E + R++
Sbjct: 1395 --KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN 1452
Query: 388 -------FKDRTNKMGKRLQIMTKRYEALE----------RRRILEVEGFKTDIKVLRQK 430
+K + ++ L+ K +L + ++E + + K L+++
Sbjct: 1453 FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEE 1512
Query: 431 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRA--HKIQGELKNLKSKVFGLENEL 485
+ DL + + + N + + L E S+ + +++G L++ +SK+ ++ EL
Sbjct: 1513 ISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLEL 1569
Score = 41.2 bits (95), Expect = 0.002
Identities = 68/346 (19%), Positives = 149/346 (43%), Gaps = 61/346 (17%)
Query: 193 KADPKISKRRPSRERKESSEHYQRDIQTLIL---QVEALQAQLGEQTKLSRE-------- 241
K D ++ + + ++ E + I++ IL +V+ L +L E+ +++ E
Sbjct: 888 KNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947
Query: 242 -----QIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSEN 296
++ I+D + L +++ + +NK+K L++ + +E + + TK+ L+ +
Sbjct: 948 EDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAH 1007
Query: 297 QNKEKSWMLEKDNL--------------------MSKIKQYRVQCKKKEDKIGKVLPVMH 336
Q +E+D + + + K+ R ++ + K+ L +
Sbjct: 1008 QQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQ 1067
Query: 337 ES----HHAQSEYIKSLKDKLVQEKKL-SNMYQEQCISLE------EELARIRE------ 379
ES + + + + LK K + +L + + EQ SL+ E ARI E
Sbjct: 1068 ESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE 1127
Query: 380 -EEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQML 438
E +R +I K R++ + + L+ +++R E ++E K ++ +DLE+
Sbjct: 1128 AEHTLRAKIEKQRSD-LARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186
Query: 439 YK-----ATVNARANQDLALLCEVRDSNRRA-HKIQGELKNLKSKV 478
+ AT+ + +A L E D+ +R K++ E LK ++
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232
Score = 38.9 bits (89), Expect = 0.011
Identities = 59/294 (20%), Positives = 118/294 (40%), Gaps = 56/294 (19%)
Query: 192 FKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRR 251
FK P + +E E ++R + L + EA + +L E++ L++++
Sbjct: 838 FKIKPLLKSAEAEKEMATMKEDFERTKEELA-RSEARRKEL-------EEKMVSLLQEKN 889
Query: 252 IHLEEIQVQHQ-RNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNL 310
++QVQ + N +E + L ++ LL K+ + E + + +K NL
Sbjct: 890 DL--QLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947
Query: 311 MSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL 370
K K+ D + L + + HA +K+L +++ +L
Sbjct: 948 EDKCSSL----KRDIDDLELTLTKVEKEKHATENKVKNLSEEMT--------------AL 989
Query: 371 EEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTDIKVLRQK 430
EE ++++ +E+ +E + + LQ+ + L K + K L Q+
Sbjct: 990 EENISKLTKEKKSLQEAHQQTLDD----LQVEEDKVNGL----------IKINAK-LEQQ 1034
Query: 431 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 484
DLE L Q+ L ++ + R K++G+LK + + LEN+
Sbjct: 1035 TDDLEGSL---------EQEKKLRADLERAKR---KLEGDLKMSQESIMDLEND 1076
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 62.0 bits (149), Expect = 1e-09
Identities = 90/439 (20%), Positives = 184/439 (41%), Gaps = 35/439 (7%)
Query: 22 VAVSGPTKRRGMADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAEC----EAE---NE 74
V S + RG D++ S + + K+ + LE +Q + C EAE
Sbjct: 1955 VVTSERNQLRGELDTM-SKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
Query: 75 DLLKKL-----ELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 129
+LL+ L EL K+ Q KL+ +++ + L K + Q+ + + +L
Sbjct: 2014 ELLQTLSSDVSELLKDKTHLQEKLQS--LEKDSQALSLTKCELENQIAQLNKEKELLVKE 2071
Query: 130 SENDRLRIRELE-DKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVG-ECEQS 187
SE+ + R+ E + +K + L + GE +V L++ I+ + E
Sbjct: 2072 SESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD 2131
Query: 188 ESSAFKADPKISKR-RPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGL 246
E K+ +R R + K+ E+ +R++Q + + + L E +K E ++
Sbjct: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERELQ-MSEENQELVILDAENSKAEVETLKTQ 2190
Query: 247 IEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLE 306
IE+ L+ ++ +++ + LTK + Q L E K +S + KE++ +
Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQI 2250
Query: 307 KDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQ 366
K+ + ++ + Q K ++ + + + +SL + +E +L N ++
Sbjct: 2251 KEESKTAVEMLQNQLK----ELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306
Query: 367 CISLEEE-------LARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEG 419
LE + L +++E E ++ K R + + L+I E LE E
Sbjct: 2307 RARLEADEKKQLCVLQQLKESE-HHADLLKGRVENLERELEIARTNQE----HAALEAEN 2361
Query: 420 FKTDIKVLRQKLKDLEQML 438
K +++ L+ K++ + Q L
Sbjct: 2362 SKGEVETLKAKIEGMTQSL 2380
Score = 49.3 bits (116), Expect = 8e-06
Identities = 89/487 (18%), Positives = 194/487 (39%), Gaps = 71/487 (14%)
Query: 50 AKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEG----QHKLECDLQQREEEIA 105
AK+ + L + + +E E+L +L+ +E E LQ++E+E
Sbjct: 2371 AKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKV 2430
Query: 106 ELQK----ALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVT 161
++++ A+ +Q L + E V L+++ + + +E + + + + + + ++
Sbjct: 2431 QMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKE----QNLSSQVECLELEKAQLL 2486
Query: 162 YFCKEPPHKVTILQKTIQA-VGECEQSESSAFKADPKISKRRPSRERKES---------S 211
E + +LQ ++ + E E + K D +IS+ + + +E
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG 2546
Query: 212 EHYQRDIQTLILQVEALQAQLGEQTKLSR--------EQIEGLIEDRRIHLEEIQVQHQR 263
EH Q L L+ ++ + Q S+ E ++ ++ LE ++
Sbjct: 2547 EHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMS 2606
Query: 264 NQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQCKK 323
K+ ++T Q ++E + +L+ E ++ E L+ +IK + Q K+
Sbjct: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKE 2666
Query: 324 ---KEDKIGKVLPVMHES-------------------HHAQSEYIKSLKDKLVQEKKLSN 361
+ ++ K L MH+ H A+ ++ L D Q +
Sbjct: 2667 LTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQ 2726
Query: 362 MYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRI------- 414
Y+E+ S EE L+ + + ++ K ++ L+ T+ E L++ ++
Sbjct: 2727 TYREKLTSKEECLS----SQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN 2782
Query: 415 ---LEVEGFKTDIKVLRQKLKDLE---QMLYKATVNARANQDLALLCEVRDSNRRAHKIQ 468
E E + +K+L + K LE ++L K +A Q+ V D+ + ++
Sbjct: 2783 QLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDT--KVDELT 2840
Query: 469 GELKNLK 475
E+K LK
Sbjct: 2841 TEIKELK 2847
Score = 47.4 bits (111), Expect = 3e-05
Identities = 79/436 (18%), Positives = 180/436 (41%), Gaps = 59/436 (13%)
Query: 63 QKKMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQER 122
+K + E + EN DL +KLE + CD Q+ + + + SD+++ +
Sbjct: 1829 EKIVGELKKENSDLSEKLEYF----------SCDHQELLQRVETSEGLNSDLEMHADKSS 1878
Query: 123 EHVL--RLYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQA 180
+ + ND + R L+ ++N L+ + ++ + H+ L+ ++
Sbjct: 1879 REDIGDNVAKVNDSWKERFLD----VENELSRIRSEKASI-------EHEALYLEADLEV 1927
Query: 181 VGECEQSESSAFKADPKISKRRPSRERKESS------EHYQRDIQTLILQVEALQAQLGE 234
V Q+E + D + ++ +E S + ++ T+ + AL QL E
Sbjct: 1928 V----QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALD-QLSE 1982
Query: 235 QTKLSREQIEGLIED--RRIHLEEIQVQH-----QRNQNKIKELTKNLHHTQELLYESTK 287
+ K +++E + I + E +V+ Q + + EL K+ H QE L K
Sbjct: 1983 KMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK 2042
Query: 288 DFLQL---RSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSE 344
D L + E +N+ EK+ L+ + + + + + + + V + + + E
Sbjct: 2043 DSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGE 2102
Query: 345 YIKSLKDKLVQEKKLSNMYQEQCISLEEE------LARIREEEGMRREIFKDRTNKMGKR 398
+ L + +L ++ + +E + +A +E + KD+ + +
Sbjct: 2103 FALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERE 2162
Query: 399 LQIMTKRYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVR 458
LQ+ + E + IL+ E K +++ L+ +++++ + L ++ + L E
Sbjct: 2163 LQMSEENQELV----ILDAENSKAEVETLKTQIEEMARSLKVFELDL-----VTLRSEKE 2213
Query: 459 DSNRRAHKIQGELKNL 474
+ ++ + QG+L L
Sbjct: 2214 NLTKQIQEKQGQLSEL 2229
Score = 46.6 bits (109), Expect = 5e-05
Identities = 83/390 (21%), Positives = 166/390 (42%), Gaps = 75/390 (19%)
Query: 70 EAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLY 129
+A+N + + EL K Q +LE +L++ ++++ ++A Q+ +E+ LR
Sbjct: 427 QAKNMHNVLQAELDKLTSVKQ-QLENNLEEFKQKLCRAEQAFQASQI-----KENELR-- 478
Query: 130 SENDRLRIRELEDKKKIQNLLALVGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSES 189
R +E+ KK NLL ++ +V L+ ++ + +C ++S
Sbjct: 479 --------RSMEEMKKENNLLKS----------HSEQKAREVCHLEAELKNIKQC-LNQS 519
Query: 190 SAFKADPKISKRRPSRERKESSEHYQRDIQTLI------LQVEALQAQLGEQTKLSREQI 243
F + K + S E RD+Q I L +E L+ + + K R+
Sbjct: 520 QNFAEEMKA--------KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEK-QRDCS 570
Query: 244 EGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKD----FLQLRSENQNK 299
+ L++ R H+E++ + + + + K L L ++ YE K+ F +SEN+
Sbjct: 571 QDLLKKREHHIEQLNDKLSKTEKESKALLSALE-LKKKEYEELKEEKTLFSCWKSENEKL 629
Query: 300 EKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSL----KDKLVQ 355
EK+NL SKI K ++ K H +E +++L ++ V+
Sbjct: 630 LTQMESEKENLQSKINHLETCLKTQQIK-----------SHEYNERVRTLEMDRENLSVE 678
Query: 356 EKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNK-----MGKRLQIMTKRYEALE 410
+ L N+ + S+E E ++ E ++ F D+ ++ M + +T + E LE
Sbjct: 679 IRNLHNVLDSK--SVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLE 736
Query: 411 RR------RILEVEGFKTDIKVLRQKLKDL 434
+ I++ + D+ + L+DL
Sbjct: 737 HKLQLLSNEIMDKDRCYQDLHAEYESLRDL 766
Score = 46.6 bits (109), Expect = 5e-05
Identities = 84/443 (18%), Positives = 184/443 (41%), Gaps = 56/443 (12%)
Query: 65 KMAECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEIAELQKALSDMQVCLFQEREH 124
K ++ + EDL KL+L + + DL E + +L K+ D + ++ +
Sbjct: 724 KTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKS-KDASLVTNEDHQR 782
Query: 125 VLRLYSENDRLRIRELEDKKKIQNLLALVG---TDAGEVTYFCKEPPHKVTILQKTIQAV 181
L + + + N++ G ++ E + P ILQ + ++
Sbjct: 783 SLLAFDQQPAMH-------HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
Query: 182 GECEQSESSAFKADPKISKR-----RPSRERKESSEHYQRDIQTLILQVEALQAQLGEQT 236
E S S + + + K+ + E +E+ ++ Q+ + + ++L E T
Sbjct: 836 ---EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDT 892
Query: 237 KLSREQIE---GLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLR 293
+ + +E++ L+ + + + Q +I+EL K+ H LL +S K+ LQL
Sbjct: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNH----LLEDSLKE-LQLL 947
Query: 294 SENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSLKDKL 353
SE + EK E +++S K+ + ++ + ++ +++ K L
Sbjct: 948 SETLSLEKK---EMSSIISLNKREIEELTQENGTLKEINASLNQE-----------KMNL 993
Query: 354 VQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEAL-ERR 412
+Q+ + Y ++ E+ ++ + ++ + I R + G + ++++Y+A E+
Sbjct: 994 IQKSESFANYIDE---REKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 413 RILE---------VEGFKTDIKVLRQKL-KDLEQMLYKATVNARANQDLALLCEVRDSNR 462
LE E K +++ L++ K+ ++ L K NQ+L L E
Sbjct: 1051 SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQAL 1110
Query: 463 RAHKIQGELKNLKSKVFGLENEL 485
R+ + N KS+ GL+ E+
Sbjct: 1111 RSEMTDNQ-NNSKSEAGGLKQEI 1132
Score = 45.8 bits (107), Expect = 9e-05
Identities = 93/481 (19%), Positives = 205/481 (42%), Gaps = 58/481 (12%)
Query: 34 ADSLESTPLPSPEDRLAKLHPSKELLEYYQKKMAECEAENEDLLKKLELYKEACEGQHKL 93
A+ + + + R++KL +E +Q +AE + E+ K+L+L + E +
Sbjct: 870 AEQMHQSFVAETSQRISKL---QEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAE 926
Query: 94 ECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLRIRELEDKKKIQNLLALV 153
+L++ + + K L + L E++ + + S N R E+E+ + L +
Sbjct: 927 IQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKR----EIEELTQENGTLKEI 982
Query: 154 GTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSA------FKADPKISKRRPSRER 207
+ K+ ++QK+ ++ E S +K + I +R E
Sbjct: 983 NASLNQ---------EKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQR-CEET 1032
Query: 208 KESSEHYQRDIQTLILQVEALQAQLGEQTKLSR------EQI-EGLIEDRRIHLEEIQVQ 260
+ E + + + L+ L E T L EQ+ E ++ + L ++
Sbjct: 1033 GNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFA 1092
Query: 261 HQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKIKQYRVQ 320
+RNQN + EL Q+ L D ++N +K ++ L+++ + K +Q ++Q
Sbjct: 1093 EERNQNLMLELET----VQQALRSEMTD-----NQNNSKSEAGGLKQEIMTLKEEQNKMQ 1143
Query: 321 CK-----KKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNM-----YQEQCISL 370
+ ++ +++ KV+ HE + +SE I++ + E+ N + + ISL
Sbjct: 1144 KEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL 1203
Query: 371 EEELARIREEEGMRR--EIFKDRTNKMGKRLQ--IMTKRYEALERRRILEVEGFKTDIKV 426
+ A++ + E M R E+ + K + LQ + T R + LE + +++ +I
Sbjct: 1204 DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGD-LETSNLQDMQ--SQEISG 1260
Query: 427 LRQKLKDLEQMLYKA--TVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENE 484
L+ D E+ ++ N + L C ++ + + ++++ + L+++ + L E
Sbjct: 1261 LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTE 1320
Query: 485 L 485
L
Sbjct: 1321 L 1321
Score = 42.0 bits (97), Expect = 0.001
Identities = 66/349 (18%), Positives = 153/349 (43%), Gaps = 57/349 (16%)
Query: 46 EDRLAKLHPSKELLEYYQKKMA-ECEAENEDLLKKLELYKEACEGQHKLECDLQQREEEI 104
+ + A L + E+L+ K + E E D + +E + + +L+ ++ + ++
Sbjct: 2573 QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKT 2632
Query: 105 AELQKALSDMQVCLFQEREHVLR-LYSENDRLRIRELEDKKKIQNLLALVGTDAGEVTYF 163
AELQ+ LS + L E + +L + S D+L+ LE+ + ++L +
Sbjct: 2633 AELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM----------- 2681
Query: 164 CKEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKRRPSRERKESSEHYQRDIQTLIL 223
HK ++ G+ + E + ++ ++++ ++++ Y+ +IQT
Sbjct: 2682 -----HK-----DQVEKEGKVRE-EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTY-- 2728
Query: 224 QVEALQAQLGEQTKLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLY 283
+ KL+ + E + +++ ++ ++ + N +K T+ L ++
Sbjct: 2729 -----------REKLTSK--EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKM 2775
Query: 284 ESTKDFLQLRSENQNKEKSWML----------EKDNLMSKIKQYRVQCKKKEDKIGKVLP 333
++ K QL+ EN+ + L EK+ L ++ Q +Q +++ K G V+
Sbjct: 2776 DNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQ--LQAAQEKQKTGTVMD 2833
Query: 334 VMHESHHAQSEYIKSLKDKLVQEKKLSNMYQEQCISL---EEELARIRE 379
+ + IK LK+ L ++ K ++ Y ++ SL E+L + +E
Sbjct: 2834 TKVDELTTE---IKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKE 2879
Score = 41.6 bits (96), Expect = 0.002
Identities = 82/456 (17%), Positives = 189/456 (41%), Gaps = 66/456 (14%)
Query: 67 AECEAENED-------LLKKLELYKEACEGQHKLECDLQQREEEIAE--------LQKAL 111
+EC E + L +++ + + E Q ++ DLQ++ EE+ + L KA
Sbjct: 812 SECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE 871
Query: 112 SDMQVCLFQEREHVLRLYSENDRLR------IRELEDK-KKIQNLLALVGTDAGEVTYFC 164
Q + + + + +L + + + LE+K K++Q L V T+ E+
Sbjct: 872 QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL- 930
Query: 165 KEPPHKVTILQKTIQAVGECEQSESSAFKADPKISKR------RPSRERKESSEHYQRDI 218
K+ H + K +Q + E E + ++KR + + KE + ++
Sbjct: 931 KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEK 990
Query: 219 QTLILQVEALQAQLGEQTKLSREQIEGLIEDRRIHL----------EEIQVQHQRNQNKI 268
LI + E+ + E+ K E + +++ I L E++ +++ Q K
Sbjct: 991 MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN 1050
Query: 269 KEL--------------TKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLMSKI 314
+L L +E + ++FL + + + ++ MLE + + +
Sbjct: 1051 SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQAL 1110
Query: 315 KQYRVQCK-KKEDKIGKVLPVMHESHHAQSEYIKSLKDKLVQEKKLSNMY--QEQCISLE 371
+ + + + G + + Q++ K + D L + ++L + + +C +LE
Sbjct: 1111 RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLE 1170
Query: 372 EELAR--IREEEGMRREI-FKDRTNKMGKRLQI-----MTKRYEALERRRILEVEGFKTD 423
E R ++E E R + FK + + K + + + EA+ R + L+++ + +
Sbjct: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKE 1230
Query: 424 IKVLRQKLKDLEQMLYKATVNARANQDLALL--CEV 457
+ L+ +L+ + L + + +Q+++ L CE+
Sbjct: 1231 KECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEI 1266
Score = 36.6 bits (83), Expect = 0.053
Identities = 82/441 (18%), Positives = 174/441 (39%), Gaps = 54/441 (12%)
Query: 88 EGQ-HKLECDLQQREEEIAELQKALSDMQVCLFQEREHVLRLYSENDRLR--IRELE-DK 143
EGQ KL+ + QQR+ ++ L+ AL + + E+ L EN RL LE K
Sbjct: 24 EGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTK 83
Query: 144 KKIQNLLAL----VGTDAGEVTYFCKEPPHKVTILQKTIQAVGECEQSESSAFKADPKI- 198
+KI + L + V G++ K+ + Q+ + E E+S+ +A AD +
Sbjct: 84 QKISHELQVKESQVNFQEGQLNSGKKQIE---KLEQELKRCKSELERSQQAAQSADVSLN 140
Query: 199 ---------------SKRRPSRERKESSEHYQRDIQ---TLILQVEALQAQLGEQT---- 236
S+ + ++ E Y ++++ L +V+ALQA+ QT
Sbjct: 141 PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA 200
Query: 237 -----KLSREQIEGLIEDRRIHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQ 291
++R Q + + + + I+ + + E ++ LQ
Sbjct: 201 TMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQ 260
Query: 292 LRSENQNKEKSWMLEKDNLMSKIKQYRVQCKKKEDKIGKVLPVMHESHHAQSEYIKSL-- 349
+ + N +L+ ++K + + K +++ L + Q + L
Sbjct: 261 IGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQL 320
Query: 350 -----KDKLVQEKKLSNMYQEQCISLEEELARIREEEGMRREIFKDRTNKMGKRLQIMTK 404
K +L++++K+ N +++ + + + + + K T + + Q
Sbjct: 321 QLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAES 380
Query: 405 RYEALERRRILEVEGFKTDIKVLRQKLKDLEQMLYKATVNARANQDLALLCEVRDSNRRA 464
+LE++ + + F+ ++ ++ + L+Q + + AR Q E++ +
Sbjct: 381 ARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQ--MKARLTQ------ELQQAKNMH 432
Query: 465 HKIQGELKNLKSKVFGLENEL 485
+ +Q EL L S LEN L
Sbjct: 433 NVLQAELDKLTSVKQQLENNL 453
Score = 35.4 bits (80), Expect = 0.12
Identities = 61/304 (20%), Positives = 119/304 (39%), Gaps = 55/304 (18%)
Query: 46 EDRLAKLHPSKELL----EYYQKKMAECEAENEDLLKKLELYKEACEGQHK--------- 92
E+R +L KE + + K+A E N++L+ +LE ++A +
Sbjct: 1065 ENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
Query: 93 ---LECDLQQREEEIAELQKALSDMQVCLFQEREHVLR----------LYSENDRLRIRE 139
L+ ++ +EE ++QK ++D L QE E +++ L SE R ++E
Sbjct: 1125 AGGLKQEIMTLKEEQNKMQKEVND----LLQENEQLMKVMKTKHECQNLESEPIRNSVKE 1180
Query: 140 LEDKKKIQNLLALVGTDAGEVT---YFCKEPPHKVTILQKTI-----QAVGECEQSESSA 191
E ++ N + + E++ Y + + + K + + EC Q E
Sbjct: 1181 RESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQT 1240
Query: 192 FKADPKISKRRPSRERKESSEHYQRDIQTLILQVEALQAQLGEQTKLSREQIEGLIEDRR 251
+ D + S + + ++ S +D + ++A + + +LS Q +
Sbjct: 1241 IRGDLETSNLQDMQSQEISG---LKDCE-----IDAEEKYISGPHELSTSQNDNA----- 1287
Query: 252 IHLEEIQVQHQRNQNKIKELTKNLHHTQELLYESTKDFLQLRSENQNKEKSWMLEKDNLM 311
+Q Q NK+ EL K Q YE + RSE + E L+
Sbjct: 1288 ----HLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLL 1343
Query: 312 SKIK 315
+++K
Sbjct: 1344 NEVK 1347
Score = 29.3 bits (64), Expect = 8.5
Identities = 29/118 (24%), Positives = 59/118 (50%), Gaps = 16/118 (13%)
Query: 374 LARIREEEGMRREIFKDRTNKMGKRLQIMTKRYEALERRRILEVEGFKTD---IKVLRQK 430
L +I+E EG ++ K++ + Q EA +++ +VE KT+ +K Q+
Sbjct: 17 LQKIQELEGQLDKLKKEKQQR-----QFQLDSLEAALQKQKQKVENEKTEGTNLKRENQR 71
Query: 431 LKDLEQMLYKATVNARANQDLALLCEVRDSNRRAHKIQGELKNLKSKVFGLENELRLC 488
L ++ + L K Q ++ +V++S + + +G+L + K ++ LE EL+ C
Sbjct: 72 LMEICESLEKT------KQKISHELQVKES--QVNFQEGQLNSGKKQIEKLEQELKRC 121
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,622,325
Number of Sequences: 37866
Number of extensions: 819806
Number of successful extensions: 7085
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 126
Number of HSP's successfully gapped in prelim test: 771
Number of HSP's that attempted gapping in prelim test: 4167
Number of HSP's gapped (non-prelim): 2392
length of query: 488
length of database: 18,247,518
effective HSP length: 106
effective length of query: 382
effective length of database: 14,233,722
effective search space: 5437281804
effective search space used: 5437281804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.