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Search of human proteins with 8922528
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8922528 kelch-like 11 [Homo sapiens]
(708 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8922528 kelch-like 11 [Homo sapiens] 1449 0.0
gi|55925608 kelch-like 21 [Homo sapiens] 182 7e-46
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 180 5e-45
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 180 5e-45
gi|40018614 DRE1 protein [Homo sapiens] 177 4e-44
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 174 2e-43
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 174 2e-43
gi|55925604 kelch-like 18 [Homo sapiens] 174 2e-43
gi|166235129 kelch-like 3 [Homo sapiens] 174 3e-43
gi|40807500 kelch-like 20 [Homo sapiens] 169 6e-42
gi|38194229 kelch-like 17 [Homo sapiens] 168 1e-41
gi|148664209 kelch-like 10 [Homo sapiens] 167 2e-41
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 165 1e-40
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 163 4e-40
gi|11056006 kelch-like 12 [Homo sapiens] 163 4e-40
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 161 2e-39
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 160 5e-39
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 157 4e-38
gi|194097389 kelch-like 38 [Homo sapiens] 156 5e-38
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 155 9e-38
gi|14780904 kelch-like 1 protein [Homo sapiens] 154 3e-37
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 153 6e-37
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 150 3e-36
gi|24308181 kelch-like 9 [Homo sapiens] 150 5e-36
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 149 7e-36
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 149 7e-36
gi|45643138 kelch-like 13 [Homo sapiens] 148 2e-35
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 146 7e-35
gi|156616301 kelch-like 32 [Homo sapiens] 146 7e-35
gi|31542246 kelch-like 36 [Homo sapiens] 144 3e-34
>gi|8922528 kelch-like 11 [Homo sapiens]
Length = 708
Score = 1449 bits (3750), Expect = 0.0
Identities = 708/708 (100%), Positives = 708/708 (100%)
Query: 1 MAAAAVAAAAAAAAAASLQVLEMESMETAAAGSAGLAAEVRGSGTVDFGPGPGISAMEAS 60
MAAAAVAAAAAAAAAASLQVLEMESMETAAAGSAGLAAEVRGSGTVDFGPGPGISAMEAS
Sbjct: 1 MAAAAVAAAAAAAAAASLQVLEMESMETAAAGSAGLAAEVRGSGTVDFGPGPGISAMEAS 60
Query: 61 GGDPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATE 120
GGDPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATE
Sbjct: 61 GGDPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATE 120
Query: 121 YFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELA 180
YFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELA
Sbjct: 121 YFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELA 180
Query: 181 DRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEE 240
DRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEE
Sbjct: 181 DRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEE 240
Query: 241 FYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPT 300
FYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPT
Sbjct: 241 FYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPT 300
Query: 301 YLTRHVKPERLVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDV 360
YLTRHVKPERLVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDV
Sbjct: 301 YLTRHVKPERLVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDV 360
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA 420
IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA
Sbjct: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA 420
Query: 421 KTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDK 480
KTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDK
Sbjct: 421 KTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDK 480
Query: 481 WHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESL 540
WHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESL
Sbjct: 481 WHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESL 540
Query: 541 PLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIE 600
PLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIE
Sbjct: 541 PLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIE 600
Query: 601 GAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVR 660
GAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVR
Sbjct: 601 GAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVR 660
Query: 661 IPYRYLHGTQRYPMPQNLMWQKDRIRQMQEIHRHALNMRRVPSSQIEC 708
IPYRYLHGTQRYPMPQNLMWQKDRIRQMQEIHRHALNMRRVPSSQIEC
Sbjct: 661 IPYRYLHGTQRYPMPQNLMWQKDRIRQMQEIHRHALNMRRVPSSQIEC 708
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 182 bits (463), Expect = 7e-46
Identities = 145/583 (24%), Positives = 260/583 (44%), Gaps = 48/583 (8%)
Query: 71 FECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQF 130
F +H L ++ R + F D+TL AGGR+F AHR+VLAAA+ YF + +GQ
Sbjct: 12 FSDPAHALSLLRGLSQLRAERKFLDVTL--EAAGGRDFPAHRAVLAAASPYFRAMFAGQL 69
Query: 131 SESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKE 190
ESR+ RV + G PD ++ ++++ YTGR+ VS + +L AD +KE
Sbjct: 70 RESRAERVRLH------GVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKE 123
Query: 191 FCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIR 250
CG FL+++L L+NC+ + A ++ S LA A I R+ + + E+ LP +
Sbjct: 124 ACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLL 182
Query: 251 DWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPER 310
+L D + V EE ++ L+WV+ + R ++ +L + +RL ++ YL HV+ E
Sbjct: 183 RYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEP 242
Query: 311 LVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNM-DVIMVIGGVSE 369
LVA C++L+ +A + A R + G C + PR + ++++++GG +
Sbjct: 243 LVARCPPCLRLLREARDFQAARYDRHDRGPCPR------MRPRPSTGLAEILVLVGGCDQ 296
Query: 370 GGDYLSECVGYFVDEDRWVNLPHIHNHL-DGHAVAVTESYVYVAGSMEPG-FAKTVERYN 427
D L Y +W L +HL G+++ + +YV G + V RYN
Sbjct: 297 DCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYN 356
Query: 428 PNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESA 487
++N W V ++ + + + G LY + Y+ D W L+
Sbjct: 357 SSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA--------DSTERYDHTTDSWEALQPM 408
Query: 488 PKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDNYC 547
+ + A R I + + V+ CYD +T W V+ L +
Sbjct: 409 TYPMDNCSTTACRGRLYAIGSLAGKE-------TMVMQCYDPDTDLWSLVDCGQL-PPWS 460
Query: 548 FFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIEGAAICYY 607
F +TA+ Y + ++ A + + +E + +P G ++
Sbjct: 461 FAP---------KTATLNGLMYFVRDDSAEVDVYNPTRNE-WDKIPSMNQVHVGGSLAVL 510
Query: 608 KDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQP 650
+++ GG+ N+ ++ Y E + W ++ +P+P
Sbjct: 511 GGKLYVSGGYDNTFELSDVVE----AYDPETRAWSVVGRLPEP 549
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 180 bits (456), Expect = 5e-45
Identities = 124/452 (27%), Positives = 207/452 (45%), Gaps = 24/452 (5%)
Query: 85 NEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 144
NE R Q L CD+T+ A E AHR VLAA + YF + +G+ SESR+ RV +++
Sbjct: 51 NELRSQNLLCDVTIV---AEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVD 107
Query: 145 SEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSN 204
T+ +I+Y+YT I+V+ +V +L A L +K+ C EFL+ +LH N
Sbjct: 108 GW------TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 205 CVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEE 264
C+ I + A M+ + L KA ++F V+ EEF L + +S ++T+ SEE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 265 VLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAD 324
+FE V+ WV + + R+ + L + +RL + YL + V+ E LV N+ C + +
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 325 AVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIM-VIGGVSEGGDYLSECVGYFVD 383
A++ H L E + V R N+ +M V+GG + EC Y
Sbjct: 282 AMKYHLLPTEQ------RILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVEC--YDFK 333
Query: 384 EDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF-AKTVERYNPNLNTWEHVCSLMTR 442
E+RW + + + + V+ G +TV+ Y+P + W V ++ R
Sbjct: 334 EERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDR 393
Query: 443 KHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDR 502
+ + G + G LY++GG S G V YN + ++W ++ V +
Sbjct: 394 RSTLGAAVLNGLLYAVGGFDG-STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 452
Query: 503 FVYIAARTPVDRDTEDGLKAVITCYDTETRQW 534
+ R + + CY+ T +W
Sbjct: 453 LYAVGGYDGASRQ----CLSTVECYNATTNEW 480
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 4/128 (3%)
Query: 376 ECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PGFAKTVERYNPNLNTWE 434
EC Y + W + + G V V + +Y G + P K+VE Y+P N W
Sbjct: 471 EC--YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWR 528
Query: 435 HVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDV 494
V + + + G+ V G LY +GG S V YNP DKW + S R
Sbjct: 529 QVADMNMCRRNAGVCAVNGLLYVVGGDDG-SCNLASVEYYNPTTDKWTVVSSCMSTGRSY 587
Query: 495 KALAIEDR 502
+ + D+
Sbjct: 588 AGVTVIDK 595
Score = 57.8 bits (138), Expect = 3e-08
Identities = 43/183 (23%), Positives = 75/183 (40%), Gaps = 11/183 (6%)
Query: 360 VIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF 419
++ +GG +G LS Y + + W ++ ++ V V +Y G +
Sbjct: 405 LLYAVGGF-DGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGAS 463
Query: 420 AK---TVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNP 476
+ TVE YN N W ++ + TR+ G+ + LY++GGH K V VY+P
Sbjct: 464 RQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG-PLVRKSVEVYDP 522
Query: 477 ELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQD 536
+ W + R+ A+ + +Y+ V D A + Y+ T +W
Sbjct: 523 TTNAWRQVADMNMCRRNAGVCAV-NGLLYV-----VGGDDGSCNLASVEYYNPTTDKWTV 576
Query: 537 VES 539
V S
Sbjct: 577 VSS 579
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 180 bits (456), Expect = 5e-45
Identities = 124/452 (27%), Positives = 207/452 (45%), Gaps = 24/452 (5%)
Query: 85 NEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 144
NE R Q L CD+T+ A E AHR VLAA + YF + +G+ SESR+ RV +++
Sbjct: 47 NELRSQNLLCDVTIV---AEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVD 103
Query: 145 SEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSN 204
T+ +I+Y+YT I+V+ +V +L A L +K+ C EFL+ +LH N
Sbjct: 104 GW------TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 205 CVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEE 264
C+ I + A M+ + L KA ++F V+ EEF L + +S ++T+ SEE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 265 VLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAD 324
+FE V+ WV + + R+ + L + +RL + YL + V+ E LV N+ C + +
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 325 AVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIM-VIGGVSEGGDYLSECVGYFVD 383
A++ H L E + V R N+ +M V+GG + EC Y
Sbjct: 278 AMKYHLLPTEQ------RILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVEC--YDFK 329
Query: 384 EDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF-AKTVERYNPNLNTWEHVCSLMTR 442
E+RW + + + + V+ G +TV+ Y+P + W V ++ R
Sbjct: 330 EERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDR 389
Query: 443 KHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDR 502
+ + G + G LY++GG S G V YN + ++W ++ V +
Sbjct: 390 RSTLGAAVLNGLLYAVGGFDG-STGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
Query: 503 FVYIAARTPVDRDTEDGLKAVITCYDTETRQW 534
+ R + + CY+ T +W
Sbjct: 449 LYAVGGYDGASRQ----CLSTVECYNATTNEW 476
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 4/128 (3%)
Query: 376 ECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PGFAKTVERYNPNLNTWE 434
EC Y + W + + G V V + +Y G + P K+VE Y+P N W
Sbjct: 467 EC--YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWR 524
Query: 435 HVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDV 494
V + + + G+ V G LY +GG S V YNP DKW + S R
Sbjct: 525 QVADMNMCRRNAGVCAVNGLLYVVGGDDG-SCNLASVEYYNPTTDKWTVVSSCMSTGRSY 583
Query: 495 KALAIEDR 502
+ + D+
Sbjct: 584 AGVTVIDK 591
Score = 57.8 bits (138), Expect = 3e-08
Identities = 43/183 (23%), Positives = 75/183 (40%), Gaps = 11/183 (6%)
Query: 360 VIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF 419
++ +GG +G LS Y + + W ++ ++ V V +Y G +
Sbjct: 401 LLYAVGGF-DGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGAS 459
Query: 420 AK---TVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNP 476
+ TVE YN N W ++ + TR+ G+ + LY++GGH K V VY+P
Sbjct: 460 RQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG-PLVRKSVEVYDP 518
Query: 477 ELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQD 536
+ W + R+ A+ + +Y+ V D A + Y+ T +W
Sbjct: 519 TTNAWRQVADMNMCRRNAGVCAV-NGLLYV-----VGGDDGSCNLASVEYYNPTTDKWTV 572
Query: 537 VES 539
V S
Sbjct: 573 VSS 575
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 177 bits (448), Expect = 4e-44
Identities = 142/543 (26%), Positives = 230/543 (42%), Gaps = 79/543 (14%)
Query: 65 GPEAEDFEC-SSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFT 123
G E DF SSH + NE R LF D+ +C G+EF HR+VL+A + YF
Sbjct: 36 GHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIIC---VEGKEFPCHRAVLSACSSYFR 92
Query: 124 PLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRF 183
+ ESR VE+ G + +E ++Y+YTG+++++T +V + E + F
Sbjct: 93 AMFCNDHRESREMLVEIN------GILAEAMECFLQYVYTGKVKITTENVQYLFETSSLF 146
Query: 184 LLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYT 243
+ L++ C +FL+++L NC+ I A ++L L K + + F V Q EEF
Sbjct: 147 QISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLE 206
Query: 244 LPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLT 303
L + D++ E+ + EE++FE V++WV R + R EL +RL + P Y
Sbjct: 207 LDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFV 266
Query: 304 RHVKPERLVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMV 363
+ V+ ++L+ N+ C +L+ +A H L E + T ++ S +VI+V
Sbjct: 267 QTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYS---------EVIVV 317
Query: 364 IGGVSEGGDY---LSECVGYFVDE------------------------------------ 384
+GG G + +EC E
Sbjct: 318 VGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDV 377
Query: 385 -------DRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PGFAKTVERYNPNLNTWEHV 436
+ W+ + ++ H +AV VYV G + +VE Y+ N W V
Sbjct: 378 WIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEV 437
Query: 437 CSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKA 496
L S +T GKL+ IGG + + V Y+PE + W + P R + A
Sbjct: 438 APLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITA 497
Query: 497 LAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDNYCFFQMSVVNS 556
+++ + +Y+A GL I CYD W V++ C MSV N
Sbjct: 498 VSL-NNLIYVAG----------GLTKAIYCYDPVEDYWMHVQNTFSRQENC--GMSVCNG 544
Query: 557 NFY 559
Y
Sbjct: 545 KIY 547
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/116 (23%), Positives = 48/116 (41%), Gaps = 4/116 (3%)
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA 420
+ VIGG + + Y + + W+ I + +YVAG G
Sbjct: 456 LFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAG----GLT 511
Query: 421 KTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNP 476
K + Y+P + W HV + +R+ + G++ GK+Y +GG + Y+P
Sbjct: 512 KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDP 567
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 174 bits (442), Expect = 2e-43
Identities = 153/617 (24%), Positives = 272/617 (44%), Gaps = 70/617 (11%)
Query: 63 DPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYF 122
+P E F+ +H + + R CD+ L AG R AHR VL++ ++YF
Sbjct: 143 EPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILV---AGDRRIPAHRLVLSSVSDYF 199
Query: 123 TPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADR 182
+ + E+R ++M G EP+++ ++I+Y YTGR+ + ++ +L A
Sbjct: 200 AAMFTNDVREARQEEIKME------GVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACL 253
Query: 183 FLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFY 242
L ++ E C +FL K+LH SNC+ I S A + L A + +F +VI+++EF
Sbjct: 254 LQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFV 313
Query: 243 TLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYL 302
LP I L+ ++ + +EE + +L WV+ + E+R + +L +RL + P +L
Sbjct: 314 LLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL 373
Query: 303 TRHVKPERLVANNEVCVKLVADAVERHAL--RAENIQSGTCQHPTSHVSLLPRYGQNMDV 360
++ L ++ C KL+ +A++ H L R +QS + S V L
Sbjct: 374 A-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTL--------- 423
Query: 361 IMVIGGV--SEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEP- 417
+GG+ ++G + + Y + + W + +++ VAV + +YV G +
Sbjct: 424 -FAVGGMDSTKGATSIEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 479
Query: 418 GFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPE 477
TVE YNP TW + + T +H G+ ++G +Y++GGH +S V ++P+
Sbjct: 480 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS-YLNTVERWDPQ 538
Query: 478 LDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDV 537
+W N + R +A+ +Y RD LK+V C+D T +W
Sbjct: 539 ARQW-NFVATMSTPRSTVGVAVLSGKLYAVG----GRDGSSCLKSV-ECFDPHTNKW--- 589
Query: 538 ESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEA-VRKIASQVSDEILESLPPEV 596
C QMS T + Y + +A + S++SD +E P+
Sbjct: 590 -------TLC-AQMSKRRGGVGVT-TWNGLLYAIGGHDAPASNLTSRLSD-CVERYDPKT 639
Query: 597 ----------LSIEGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPP 646
+S + +C D ++ +GG+ + Y Y + W + P
Sbjct: 640 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG-----QAYLNTVEAYDPQTNEWTQVAP 694
Query: 647 MPQPRC--RATACHVRI 661
+ C RA AC V +
Sbjct: 695 L----CLGRAGACVVTV 707
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 174 bits (442), Expect = 2e-43
Identities = 153/617 (24%), Positives = 272/617 (44%), Gaps = 70/617 (11%)
Query: 63 DPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYF 122
+P E F+ +H + + R CD+ L AG R AHR VL++ ++YF
Sbjct: 189 EPCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILV---AGDRRIPAHRLVLSSVSDYF 245
Query: 123 TPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADR 182
+ + E+R ++M G EP+++ ++I+Y YTGR+ + ++ +L A
Sbjct: 246 AAMFTNDVREARQEEIKME------GVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACL 299
Query: 183 FLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFY 242
L ++ E C +FL K+LH SNC+ I S A + L A + +F +VI+++EF
Sbjct: 300 LQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFV 359
Query: 243 TLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYL 302
LP I L+ ++ + +EE + +L WV+ + E+R + +L +RL + P +L
Sbjct: 360 LLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL 419
Query: 303 TRHVKPERLVANNEVCVKLVADAVERHAL--RAENIQSGTCQHPTSHVSLLPRYGQNMDV 360
++ L ++ C KL+ +A++ H L R +QS + S V L
Sbjct: 420 A-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTL--------- 469
Query: 361 IMVIGGV--SEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEP- 417
+GG+ ++G + + Y + + W + +++ VAV + +YV G +
Sbjct: 470 -FAVGGMDSTKGATSIEK---YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 525
Query: 418 GFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPE 477
TVE YNP TW + + T +H G+ ++G +Y++GGH +S V ++P+
Sbjct: 526 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS-YLNTVERWDPQ 584
Query: 478 LDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDV 537
+W N + R +A+ +Y RD LK+V C+D T +W
Sbjct: 585 ARQW-NFVATMSTPRSTVGVAVLSGKLYAVG----GRDGSSCLKSV-ECFDPHTNKW--- 635
Query: 538 ESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEA-VRKIASQVSDEILESLPPEV 596
C QMS T + Y + +A + S++SD +E P+
Sbjct: 636 -------TLC-AQMSKRRGGVGVT-TWNGLLYAIGGHDAPASNLTSRLSD-CVERYDPKT 685
Query: 597 ----------LSIEGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPP 646
+S + +C D ++ +GG+ + Y Y + W + P
Sbjct: 686 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG-----QAYLNTVEAYDPQTNEWTQVAP 740
Query: 647 MPQPRC--RATACHVRI 661
+ C RA AC V +
Sbjct: 741 L----CLGRAGACVVTV 753
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 174 bits (442), Expect = 2e-43
Identities = 127/423 (30%), Positives = 195/423 (46%), Gaps = 27/423 (6%)
Query: 68 AEDFECSSH--CSELSWR----QNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEY 121
AE+ E H SEL R E RRQG CD+TL G +F AHR VLAA+ Y
Sbjct: 6 AEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGD---HKFSAHRIVLAASIPY 62
Query: 122 FTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELAD 181
F + + E + + M+ G +P +EA+I + Y G + + +V +L A
Sbjct: 63 FHAMFTNDMMECKQDEIVMQ------GMDPSALEALINFAYNGNLAIDQQNVQSLLMGAS 116
Query: 182 RFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEF 241
L +K+ C FL+++LH NC+ + A + L A I ++F +V EEF
Sbjct: 117 FLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEF 176
Query: 242 YTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTY 301
LP + + +S E+ V SEE +FE L WV+ + E+R Y EL +RL +P +
Sbjct: 177 LALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQF 236
Query: 302 LTRHVKPERLVANNEVCVKLVADAVERHALRAENIQSGTCQ-HPTSHVSLLPRYGQNMDV 360
L+ V+ + LV C LV +A + H + + P S+ +
Sbjct: 237 LSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSI-------AGL 289
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF- 419
I +GG++ GD L+ + + W + VAV +Y G +
Sbjct: 290 IYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR 349
Query: 420 AKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGH-GNFSPGFKDVTVYNPEL 478
TVE YNP +TW V S+ +++ + G + G++Y GG+ GN S V Y+PE
Sbjct: 350 LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSS--LSSVETYSPET 407
Query: 479 DKW 481
DKW
Sbjct: 408 DKW 410
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEP-GF 419
I V GG +G LS Y + D+W + + ++ V V E +YV+G +
Sbjct: 385 IYVCGGY-DGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQI 443
Query: 420 AKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVT-VYNPEL 478
+VE YN + TW ++ ++ G + K++ GG+ GF + +Y+
Sbjct: 444 FSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYD--GSGFLSIAEMYSSVA 501
Query: 479 DKW 481
D+W
Sbjct: 502 DQW 504
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 2/119 (1%)
Query: 364 IGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PGFAKT 422
+ G +G S Y W + N H A S ++V G + GF
Sbjct: 434 VSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSI 493
Query: 423 VERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKW 481
E Y+ + W + + TR+ L G+LY++GG+ S V +Y+PE D W
Sbjct: 494 AEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQS-NLSSVEMYDPETDCW 551
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 174 bits (440), Expect = 3e-43
Identities = 113/400 (28%), Positives = 199/400 (49%), Gaps = 22/400 (5%)
Query: 85 NEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 144
NE R + L CD+ + A E AHR VLAA + YF + +G SES++ ++E++
Sbjct: 41 NELRSKQLLCDVMIV---AEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVD 97
Query: 145 SEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSN 204
+ T+ +I+Y+YT I V+ +V +L A L+ +++ C +FL+ +LH +N
Sbjct: 98 GQ------TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
Query: 205 CVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEE 264
C+ I + A ++T + L +A ++F +V+ EEF +L + +S ++TV SEE
Sbjct: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
Query: 265 VLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAD 324
+FE V+ W+ E R + +L + +RL + YL + V+ E L+ NN C + +
Sbjct: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
Query: 325 AVERHALRAEN--IQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFV 382
A++ H L + + P + VS LP+ V++V+GG + EC Y
Sbjct: 272 AMKYHLLPLDQRLLIKNPRTKPRTPVS-LPK------VMIVVGGQAPKAIRSVEC--YDF 322
Query: 383 DEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF-AKTVERYNPNLNTWEHVCSLMT 441
+EDRW + + + V +VY G +TV+ Y+ + W + S+
Sbjct: 323 EEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQE 382
Query: 442 RKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKW 481
R+ + G + LY++GG S G V Y+ + ++W
Sbjct: 383 RRSTLGAAVLNDLLYAVGGFDG-STGLASVEAYSYKTNEW 421
Score = 60.8 bits (146), Expect = 4e-09
Identities = 38/144 (26%), Positives = 63/144 (43%), Gaps = 5/144 (3%)
Query: 359 DVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPG 418
D++ +GG +G L+ Y + W + ++ V V E +Y G +
Sbjct: 394 DLLYAVGGF-DGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGA 452
Query: 419 FAK---TVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYN 475
+ TVE+YNP N W +V + TR+ G+ + G+LY+ GGH K V VY+
Sbjct: 453 SRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDG-PLVRKSVEVYD 511
Query: 476 PELDKWHNLESAPKILRDVKALAI 499
P + W + R+ A+
Sbjct: 512 PGTNTWKQVADMNMCRRNAGVCAV 535
Score = 58.2 bits (139), Expect = 3e-08
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 2/127 (1%)
Query: 374 LSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PGFAKTVERYNPNLNT 432
LS Y + W+ + + G V V +Y G + P K+VE Y+P NT
Sbjct: 457 LSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNT 516
Query: 433 WEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILR 492
W+ V + + + G+ V G LY +GG S V YNP DKW L + R
Sbjct: 517 WKQVADMNMCRRNAGVCAVNGLLYVVGGDDG-SCNLASVEYYNPVTDKWTLLPTNMSTGR 575
Query: 493 DVKALAI 499
+A+
Sbjct: 576 SYAGVAV 582
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 169 bits (429), Expect = 6e-42
Identities = 132/481 (27%), Positives = 220/481 (45%), Gaps = 31/481 (6%)
Query: 62 GDPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEY 121
G P P + H + N R+ CD+ L G ++ AHR +L+A + Y
Sbjct: 36 GVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLV---VGAKKIYAHRVILSACSPY 92
Query: 122 FTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELAD 181
F + +G+ +ESR V +R +E +I++ YT +I V G+V +L A
Sbjct: 93 FRAMFTGELAESRQTEVVIRDIDER------AMELLIDFAYTSQITVEEGNVQTLLPAAC 146
Query: 182 RFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEF 241
L ++E C EFLK++L SNC+ I + A ++ +L A + NF +V++ EEF
Sbjct: 147 LLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEF 206
Query: 242 YTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTY 301
LP + + D +S E+ V SEE +F V+ WV+ + +ER ++ + +RL + P +
Sbjct: 207 MLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKF 266
Query: 302 LTRHVKPERLVANNEVCVKLVADAVERHALRAEN-IQSGTCQHPTSHVSLLPRYGQNMDV 360
L V + L+ ++E C LV +A L E + G P + R G +V
Sbjct: 267 LVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPI----RCG---EV 319
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PGF 419
+ +GG GD +S Y + W + + G V+V + +Y G + +
Sbjct: 320 LFAVGGWC-SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSY 378
Query: 420 AKTVERYNPNLNTW-EHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPEL 478
+VERY+P N W V T + S G+ + G LY++GG S V Y+P+
Sbjct: 379 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVS-CLNIVERYDPKE 437
Query: 479 DKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITC--YDTETRQWQD 536
+KW + S V A+A+ F+Y + DG + T Y+ + +W
Sbjct: 438 NKWTRVASMSTRRLGV-AVAVLGGFLYAVGGS-------DGTSPLNTVERYNPQENRWHT 489
Query: 537 V 537
+
Sbjct: 490 I 490
Score = 56.6 bits (135), Expect = 8e-08
Identities = 33/122 (27%), Positives = 57/122 (46%), Gaps = 3/122 (2%)
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA 420
+ +GG S+G L+ Y E+RW + + AV + +Y G +
Sbjct: 462 LYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTE 520
Query: 421 -KTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELD 479
+ ERYNP N W V ++ +R+ GL V G+L ++GG + K + V++P+ +
Sbjct: 521 LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDG-TTYLKTIEVFDPDAN 579
Query: 480 KW 481
W
Sbjct: 580 TW 581
Score = 33.1 bits (74), Expect = 0.91
Identities = 22/95 (23%), Positives = 43/95 (45%), Gaps = 2/95 (2%)
Query: 359 DVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-P 417
D+I +GG + + LS Y ++W + + + G +AV + G +
Sbjct: 507 DMIYAVGGRDDTTE-LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGT 565
Query: 418 GFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVK 452
+ KT+E ++P+ NTW + R+ G+ +K
Sbjct: 566 TYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIK 600
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 168 bits (426), Expect = 1e-41
Identities = 123/458 (26%), Positives = 207/458 (45%), Gaps = 26/458 (5%)
Query: 85 NEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 144
+ R++GL CDI L +E RAH+ VLA+ + YF + + + SESR V +
Sbjct: 83 SRMRQRGLLCDIVL---HVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDI- 138
Query: 145 SEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSN 204
+P ++ ++++ YT I V G+V +L A L +++ C +FL +L SN
Sbjct: 139 -----DPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
Query: 205 CVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEE 264
C+ I A ++ S L A + ++F V + EEF LP + + +S + V SEE
Sbjct: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
Query: 265 VLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAD 324
++ VL WV+ + + R ++ L K +RL + +L HV E LV ++ C L+ +
Sbjct: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
Query: 325 AVERHALRAENIQSGTCQHPTSHVSLLPRYGQNM-DVIMVIGGVSEGGDYLSECVGYFVD 383
A++ H L + GT + PR + V+ +GG S + +C Y
Sbjct: 314 ALKFHLLPEQRGVLGTSR-------TRPRRCEGAGPVLFAVGGGSLFAIH-GDCEAYDTR 365
Query: 384 EDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PGFAKTVERYNPNLNTWEHVCSLMTR 442
DRW + + VA + +Y G + TVE Y+P NTW+ S+ TR
Sbjct: 366 TDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTR 425
Query: 443 KHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDR 502
+ G+ + G LYS GG+ S Y+P W ++ + R V+ ++
Sbjct: 426 RSCLGVAALHGLLYSAGGYDGAS-CLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGN 484
Query: 503 FVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESL 540
+ D+ L A + Y+ + W V S+
Sbjct: 485 LYAVGG-----YDSSSHL-ATVEKYEPQVNVWSPVASM 516
Score = 54.3 bits (129), Expect = 4e-07
Identities = 42/175 (24%), Positives = 72/175 (41%), Gaps = 8/175 (4%)
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPG-F 419
++ G +G L+ Y W ++ + VA + +Y G +
Sbjct: 437 LLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH 496
Query: 420 AKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELD 479
TVE+Y P +N W V S+++R+ S G+ ++G LY GG+ S V Y+P+
Sbjct: 497 LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTS-CLNSVERYSPKAG 555
Query: 480 KWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQW 534
W ++ + I R L D ++Y D L + I Y+ T +W
Sbjct: 556 AWESV-APMNIRRSTHDLVAMDGWLYAVG----GNDGSSSLNS-IEKYNPRTNKW 604
Score = 37.7 bits (86), Expect = 0.037
Identities = 18/88 (20%), Positives = 39/88 (44%), Gaps = 1/88 (1%)
Query: 362 MVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA- 420
+ + G ++G L+ Y W ++ ++ H + + ++Y G + +
Sbjct: 532 LYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSL 591
Query: 421 KTVERYNPNLNTWEHVCSLMTRKHSFGL 448
++E+YNP N W + TR+ S G+
Sbjct: 592 NSIEKYNPRTNKWVAASCMFTRRSSVGV 619
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 167 bits (424), Expect = 2e-41
Identities = 120/456 (26%), Positives = 213/456 (46%), Gaps = 31/456 (6%)
Query: 85 NEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 144
NE R +G CD+ + G EF AH+++L + + YF L + ++ + +K
Sbjct: 30 NELRLEGKLCDVVI---KVNGFEFSAHKNILCSCSSYFRALFTSGWNNTE------KKVY 80
Query: 145 SEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSN 204
+ PG PD ++ +IEY YT + ++ +V ++L AD+F ++ + C EFLK +L L N
Sbjct: 81 NIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDN 140
Query: 205 CVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQ-DEEFYTLPFHLIRDWLSDLEITVDSE 263
C+ I Y +L KA I NF ++++ EF L ++D + E+ V E
Sbjct: 141 CIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQE 200
Query: 264 EVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVA 323
+ +FE +LKW+ + + R+++ L +RL+ M Y +VK V ++E C ++
Sbjct: 201 DAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVII 260
Query: 324 DAVE-RHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFV 382
+A++ + L + +P L R ++ IGG S GG + Y
Sbjct: 261 NALKAMYDLNMNGPSNSDFTNP------LTRPRLPYAILFAIGGWS-GGSPTNAIEAYDA 313
Query: 383 DEDRWVNLP-HIHNHLDGHAVAVTESYVYVAGSMEP-GFAKTVERYNPNLNTWEHVCSLM 440
DRWVN+ + H A + YVY+ G + + +V+R++P TW V +
Sbjct: 314 RADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMH 373
Query: 441 TRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIE 500
+R+ +T + +Y++GG + Y PE ++W + + D A +
Sbjct: 374 SRRCYVSVTVLGNFIYAMGGFDGY-VRLNTAERYEPETNQWTLIAPMHEQRSDASATTLY 432
Query: 501 DRFVYIAARTPVDRDTEDGLKAVITC--YDTETRQW 534
+ VYI +G + + T Y+TE+ QW
Sbjct: 433 GK-VYICGGF-------NGNECLFTAEVYNTESNQW 460
Score = 53.9 bits (128), Expect = 5e-07
Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 7/139 (5%)
Query: 346 SHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVT 405
S S YG+ + + GG + G + L Y + ++W + + + G V
Sbjct: 424 SDASATTLYGK----VYICGGFN-GNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAY 478
Query: 406 ESYVYVAGSME-PGFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNF 464
+VY G + ++ E Y+P NTW + ++ + +FG+ V L+ +GG F
Sbjct: 479 GEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGF 538
Query: 465 SPGFKDVTVYNPELDKWHN 483
+ F +V Y+ + D+W++
Sbjct: 539 TTTF-NVECYDEKTDEWYD 556
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 165 bits (418), Expect = 1e-40
Identities = 126/478 (26%), Positives = 218/478 (45%), Gaps = 42/478 (8%)
Query: 76 HCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRS 135
H +L N R+ CDI L G + AH+ VLA+ + YF + +G SE +
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDV---KIHAHKVVLASVSPYFKAMFTGNLSEKEN 73
Query: 136 GRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEF 195
VE + + ++A++EY YTG + +S +V +L A+ + + + C F
Sbjct: 74 SEVEFQCI------DETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAF 127
Query: 196 LKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSD 255
L+ +L NC+ I A Y L L A I +NF V Q EEF+ L + + +S+
Sbjct: 128 LESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSN 187
Query: 256 LEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANN 315
+ V +EE +F + W++ + +ER++Y +L +RL + +LTR + L+ ++
Sbjct: 188 DCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDD 247
Query: 316 EVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLL---PRYGQNMDVIMVIGGVSEGGD 372
C L+ +A++ H + +H SH ++L PR V+ +GG S
Sbjct: 248 RTCKHLLNEALKYHFMP---------EHRLSHQTVLMTRPRCAPK--VLCAVGGKSGLFA 296
Query: 373 YLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAG----SMEPGFA-----KTV 423
L YF D W+ L ++ + V + VYV G ++ PG +V
Sbjct: 297 CLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSV 356
Query: 424 ERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHN 483
E +NP+ NTW + + + + G+ + G+LY++GG+ S + V Y P++ KW
Sbjct: 357 ECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQS-YLQSVEKYIPKIRKWQP 415
Query: 484 LESAPKILRDVKALAIEDRFVY-IAARTPVDRDTEDGLKAVITCYDTETRQWQDVESL 540
+ + R A A+ D +Y I P ++ + YD W+ V S+
Sbjct: 416 V-APMTTTRSCFAAAVLDGMIYAIGGYGPAHMNS-------VERYDPSKDSWEMVASM 465
Score = 61.2 bits (147), Expect = 3e-09
Identities = 37/146 (25%), Positives = 67/146 (45%), Gaps = 3/146 (2%)
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA 420
+ +GG +G YL Y +W + + A AV + +Y G P
Sbjct: 388 LYALGGY-DGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHM 446
Query: 421 KTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDK 480
+VERY+P+ ++WE V S+ ++ FG+ + G ++ +GGH S + Y+P ++
Sbjct: 447 NSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS-HLSSIERYDPHQNQ 505
Query: 481 WHNLESAPKILRDVKALAIEDRFVYI 506
W + V A A+ D ++Y+
Sbjct: 506 WTVCRPMKEPRTGVGA-AVIDNYLYV 530
Score = 43.5 bits (101), Expect = 7e-04
Identities = 34/132 (25%), Positives = 55/132 (41%), Gaps = 6/132 (4%)
Query: 360 VIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEP-G 418
+I IGG G +++ Y +D W + + + V V +++V G
Sbjct: 434 MIYAIGGY--GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS 491
Query: 419 FAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPEL 478
++ERY+P+ N W + + G + LY +GGH S V Y+P
Sbjct: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSG-SSYLNTVQKYDPIS 550
Query: 479 DKWHNLESAPKI 490
D W L+SA I
Sbjct: 551 DTW--LDSAGMI 560
Score = 43.5 bits (101), Expect = 7e-04
Identities = 27/96 (28%), Positives = 46/96 (47%), Gaps = 2/96 (2%)
Query: 355 GQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGS 414
G + I V+GG G +LS Y +++W + G AV ++Y+YV G
Sbjct: 475 GVMLGFIFVVGG-HNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG 533
Query: 415 ME-PGFAKTVERYNPNLNTWEHVCSLMTRKHSFGLT 449
+ TV++Y+P +TW ++ + +FGLT
Sbjct: 534 HSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLT 569
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 163 bits (413), Expect = 4e-40
Identities = 139/603 (23%), Positives = 257/603 (42%), Gaps = 50/603 (8%)
Query: 69 EDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSG 128
E F +H + + ++ CD+ L AG AHR VL+A ++YF + +
Sbjct: 157 EQFHVINHAEQTLRKMENYLKEKQLCDVLLI---AGHLRIPAHRLVLSAVSDYFAAMFTN 213
Query: 129 QFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRL 188
E++ V M G +P+ + ++++Y YTG +++ ++ +L A L ++
Sbjct: 214 DVLEAKQEEVRME------GVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQV 267
Query: 189 KEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHL 248
+ C FL K+LH SNC+ I S ++L A +F +VI+++EF LP +
Sbjct: 268 IDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANE 327
Query: 249 IRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKP 308
I L +I V EE +F +++WV + + R+ L +RL + P L ++
Sbjct: 328 ISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLA-DLET 386
Query: 309 ERLVANNEVCVKLVADAVERHAL--RAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGG 366
+ + C KL+ +A++ H L R +QS + S V L G MD +
Sbjct: 387 SSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVG-GMDAMKGTTT 445
Query: 367 VSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEP-GFAKTVER 425
+ + Y + + W+++ ++ VAV ++ +YV G + TVE
Sbjct: 446 IEK----------YDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVEC 495
Query: 426 YNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLE 485
+NP W + + T +H G+ ++G +Y++GGH +S V ++PE +W+ +
Sbjct: 496 FNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS-YLNTVERWDPEGRQWNYVA 554
Query: 486 SAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPL--- 542
S V +A+ ++ I RD LK+ + +D T +W +
Sbjct: 555 SMSTPRSTVGVVALNNKLYAIGG-----RDGSSCLKS-MEYFDPHTNKWSLCAPMSKRRG 608
Query: 543 ---IDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSI 599
+ Y F V + + C S C+E + + ++ P +
Sbjct: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDP--------KGDSWSTVAPLSVPR 660
Query: 600 EGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHV 659
+ A+C D ++++GG+ Y Y A+R W P+ R A V
Sbjct: 661 DAVAVCPLGDKLYVVGGYDG-----HTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVVV 715
Query: 660 RIP 662
++P
Sbjct: 716 KLP 718
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 163 bits (413), Expect = 4e-40
Identities = 146/549 (26%), Positives = 238/549 (43%), Gaps = 71/549 (12%)
Query: 61 GGDPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATE 120
GG P+ D ++H + N R+ CD+TL ++F AHR VLAA ++
Sbjct: 2 GGIMAPK--DIMTNTHAKSILNSMNSLRKSNTLCDVTL---RVEQKDFPAHRIVLAACSD 56
Query: 121 YFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELA 180
YF + + + SE V+++ G T+E +++++YT + V+ +V E+L A
Sbjct: 57 YFCAMFTSELSEKGKPYVDIQ------GLTASTMEILLDFVYTETVHVTVENVQELLPAA 110
Query: 181 DRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEE 240
L +K+ C EFL+ +L SNC+ I A + L A +++F +V+Q EE
Sbjct: 111 CLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEE 170
Query: 241 FYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPT 300
F L + + EI VDSEE +FE V+ WV+ +ERE L + +R+ + P
Sbjct: 171 FILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPR 230
Query: 301 YLTRHVKPERLVANNEVCVKLVADAVERHALRAE---NIQS------------------- 338
Y+T + E + + C LV +A + H LR E +Q
Sbjct: 231 YITDVIDAEPFIRCSLQCRDLVDEAKKFH-LRPELRSQMQGPRTRARLGANEVLLVVGGF 289
Query: 339 GTCQHP----------TSHVSLLP------RYGQNM---DVIMVIGGVSEGGDYLS--EC 377
G+ Q P T S LP RY ++ D I VIGG +G LS EC
Sbjct: 290 GSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGY-DGRSRLSSVEC 348
Query: 378 VGYFVDEDR-WVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFAKT-VERYNPNLNTWEH 435
+ Y DED W ++ ++ +YV+G + T +ERY+PN++ W
Sbjct: 349 LDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSM 408
Query: 436 VCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVK 495
+ + T + GL G +Y +GG+ + V Y+P W N+ + R
Sbjct: 409 LGDMQTAREGAGLVVASGVIYCLGGYDGLNI-LNSVEKYDPHTGHWTNV-TPMATKRSGA 466
Query: 496 ALAIEDRFVYIAARTPVDRDTEDGLK--AVITCYDTETRQWQDVESLPLIDNYCFFQMSV 553
+A+ + +Y+ DG + + Y+ T W V S + C+ +V
Sbjct: 467 GVALLNDHIYVVGGF-------DGTAHLSSVEAYNIRTDSWTTVTS--MTTPRCYVGATV 517
Query: 554 VNSNFYQTA 562
+ Y A
Sbjct: 518 LRGRLYAIA 526
Score = 57.8 bits (138), Expect = 3e-08
Identities = 36/128 (28%), Positives = 60/128 (46%), Gaps = 3/128 (2%)
Query: 360 VIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PG 418
VI +GG +G + L+ Y W N+ + G VA+ ++YV G +
Sbjct: 427 VIYCLGGY-DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
Query: 419 FAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPEL 478
+VE YN ++W V S+ T + G T ++G+LY+I G+ S + Y+P +
Sbjct: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSL-LSSIECYDPII 544
Query: 479 DKWHNLES 486
D W + S
Sbjct: 545 DSWEVVTS 552
Score = 36.2 bits (82), Expect = 0.11
Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 2/97 (2%)
Query: 359 DVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVY-VAGSMEP 417
D I V+GG +G +LS Y + D W + + V +Y +AG
Sbjct: 473 DHIYVVGGF-DGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGN 531
Query: 418 GFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGK 454
++E Y+P +++WE V S+ T++ G+ ++ K
Sbjct: 532 SLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK 568
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 161 bits (408), Expect = 2e-39
Identities = 119/500 (23%), Positives = 224/500 (44%), Gaps = 62/500 (12%)
Query: 85 NEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 144
N R+Q CD+ L R+ AHR VLAAA+ +F + + ES+S VE++
Sbjct: 35 NNMRKQKTLCDVILM---VQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKD-- 89
Query: 145 SEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSN 204
EPD +E ++E+ YT RI V++ +V +L+ A+++ + +K+ C +FLK+++ SN
Sbjct: 90 ----AEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASN 145
Query: 205 CVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEE 264
C+ I LA +L A D I ++F +V + +EF L + L+ +TV +E+
Sbjct: 146 CLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAED 205
Query: 265 VLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAD 324
+++ ++W++ + R+ + ++ +R + +L++ V+ E L+ +N C+K+V
Sbjct: 206 QVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVIS 265
Query: 325 AVERHALRAEN---IQSGTCQHPTSHVSLLPRYGQNM----------------------- 358
+ H L E+ + GT H + +G +
Sbjct: 266 GMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEK 325
Query: 359 ----------DVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESY 408
+V+ ++GG +C Y V +D W + D A E
Sbjct: 326 RRDAACVFWDNVVYILGGSQLFPIKRMDC--YNVVKDSWYSKLGPPTPRDSLAACAAEGK 383
Query: 409 VYVAGSMEPGFAK--TVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGH-GNFS 465
+Y +G E G + E Y+ +W S++T++ S G+ E G +Y GG GN
Sbjct: 384 IYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNV 443
Query: 466 PG--FKDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAV 523
G VY+P + W L + ++ + ++D+ + ++GL +
Sbjct: 444 SGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGG--------QNGLGGL 495
Query: 524 --ITCYDTETRQWQDVESLP 541
+ YD + +W+ V +P
Sbjct: 496 DNVEYYDIKLNEWKMVSPMP 515
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/177 (25%), Positives = 74/177 (41%), Gaps = 17/177 (9%)
Query: 366 GVSEGGD---YLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAG-----SMEP 417
G SE G+ YL EC Y + W P + H + +YV G ++
Sbjct: 388 GGSEVGNSALYLFEC--YDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSG 445
Query: 418 GFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPE 477
+ E Y+P TW +C ++ + + GL VK K++++GG G +V Y+ +
Sbjct: 446 RVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLG-GLDNVEYYDIK 504
Query: 478 LDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQW 534
L++W + P VK A+ +A V G I Y+TET +W
Sbjct: 505 LNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGV------GRLGHILEYNTETDKW 555
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/227 (22%), Positives = 84/227 (37%), Gaps = 24/227 (10%)
Query: 426 YNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLE 485
+NP +W + ++ +Y +GG F K + YN D W++ +
Sbjct: 309 FNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP--IKRMDCYNVVKDSWYS-K 365
Query: 486 SAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDN 545
P RD A + +Y + + V + CYDT T W S ++
Sbjct: 366 LGPPTPRDSLAACAAEGKIYTSGGSEVGNSA----LYLFECYDTRTESWHTKPS--MLTQ 419
Query: 546 YCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIAS-QVSDEILES---LPPEVLSIEG 601
C M N Y C S L N + R + S +V D E+ L P + + +
Sbjct: 420 RCSHGMVEANGLIY----VCGGS--LGNNVSGRVLNSCEVYDPATETWTELCPMIEARKN 473
Query: 602 AAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMP 648
+ + KD +F +GG +D Y + W ++ PMP
Sbjct: 474 HGLVFVKDKIFAVGGQNGLGGLD-----NVEYYDIKLNEWKMVSPMP 515
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 160 bits (404), Expect = 5e-39
Identities = 134/582 (23%), Positives = 249/582 (42%), Gaps = 50/582 (8%)
Query: 69 EDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSG 128
E F +H + + ++ CD+ L AG AHR VL+A ++YF + +
Sbjct: 157 EQFHVINHAEQTLRKMENYLKEKQLCDVLLI---AGHLRIPAHRLVLSAVSDYFAAMFTN 213
Query: 129 QFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRL 188
E++ V M G +P+ + ++++Y YTG +++ ++ +L A L ++
Sbjct: 214 DVLEAKQEEVRME------GVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQV 267
Query: 189 KEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHL 248
+ C FL K+LH SNC+ I S ++L A +F +VI+++EF LP +
Sbjct: 268 IDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANE 327
Query: 249 IRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKP 308
I L +I V EE +F +++WV + + R+ L +RL + P L ++
Sbjct: 328 ISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLA-DLET 386
Query: 309 ERLVANNEVCVKLVADAVERHAL--RAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGG 366
+ + C KL+ +A++ H L R +QS + S V L G MD +
Sbjct: 387 SSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVG-GMDAMKGTTT 445
Query: 367 VSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEP-GFAKTVER 425
+ + Y + + W+++ ++ VAV ++ +YV G + TVE
Sbjct: 446 IEK----------YDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVEC 495
Query: 426 YNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLE 485
+NP W + + T +H G+ ++G +Y++GGH +S V ++PE +W+ +
Sbjct: 496 FNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWS-YLNTVERWDPEGRQWNYVA 554
Query: 486 SAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPL--- 542
S V +A+ ++ I RD LK+ + +D T +W +
Sbjct: 555 SMSTPRSTVGVVALNNKLYAIGG-----RDGSSCLKS-MEYFDPHTNKWSLCAPMSKRRG 608
Query: 543 ---IDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSI 599
+ Y F V + + C S C+E + + ++ P +
Sbjct: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDP--------KGDSWSTVAPLSVPR 660
Query: 600 EGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRW 641
+ A+C D ++++GG+ Y Y A+R W
Sbjct: 661 DAVAVCPLGDKLYVVGGYDG-----HTYLNTVESYDAQRNEW 697
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 157 bits (396), Expect = 4e-38
Identities = 140/568 (24%), Positives = 253/568 (44%), Gaps = 67/568 (11%)
Query: 112 RSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTG 171
R VL++ ++YF + + E+R ++M G EP+++ ++I+Y YTGR+ +
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKME------GVEPNSLWSLIQYAYTGRLELKED 227
Query: 172 SVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRN 231
++ +L A L ++ E C +FL K+LH SNC+ I S A + L A + +
Sbjct: 228 NIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEH 287
Query: 232 FHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKL 291
F +VI+++EF LP I L+ ++ + +EE + +L WV+ + E+R + +L
Sbjct: 288 FMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAY 347
Query: 292 LRLSQMKPTYLTRHVKPERLVANNEVCVKLVADAVERHAL--RAENIQSGTCQHPTSHVS 349
+RL + P +L ++ L ++ C KL+ +A++ H L R +QS + S V
Sbjct: 348 IRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVG 406
Query: 350 LLPRYGQNMDVIMVIGGV--SEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTES 407
L +GG+ ++G + + Y + + W + +++ VAV +
Sbjct: 407 TL----------FAVGGMDSTKGATSIEK---YDLRTNMWTPVANMNGRRLQFGVAVLDD 453
Query: 408 YVYVAGSMEP-GFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSP 466
+YV G + TVE YNP TW + + T +H G+ ++G +Y++GGH +S
Sbjct: 454 KLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS- 512
Query: 467 GFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITC 526
V ++P+ +W N + R +A+ +Y RD LK+V C
Sbjct: 513 YLNTVERWDPQARQW-NFVATMSTPRSTVGVAVLSGKLYAVG----GRDGSSCLKSV-EC 566
Query: 527 YDTETRQWQDVESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEA-VRKIASQVS 585
+D T +W C QMS T + Y + +A + S++S
Sbjct: 567 FDPHTNKW----------TLC-AQMSKRRGGVGVT-TWNGLLYAIGGHDAPASNLTSRLS 614
Query: 586 DEILESLPPEV----------LSIEGAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYC 635
D +E P+ +S + +C D ++ +GG+ + Y Y
Sbjct: 615 D-CVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG-----QAYLNTVEAYD 668
Query: 636 AERKRWMLLPPMPQPRC--RATACHVRI 661
+ W + P+ C RA AC V +
Sbjct: 669 PQTNEWTQVAPL----CLGRAGACVVTV 692
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 156 bits (395), Expect = 5e-38
Identities = 113/483 (23%), Positives = 219/483 (45%), Gaps = 28/483 (5%)
Query: 71 FECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQF 130
F+ S+L + N R+ + D+++C AG RE HR+VLA+++ YF + F
Sbjct: 11 FKDHDFSSDLLRQLNSLRQSRILTDVSIC---AGAREIPCHRNVLASSSPYFRAMFCSSF 67
Query: 131 SESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKE 190
E +V+++ G +P T++ ++ Y+YTG ++T +V V+E A +L E
Sbjct: 68 REKSEAKVQLK------GIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFE 121
Query: 191 FCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIR 250
C +L+ +L SNC+ + L+ + + L KA ++ +F +V + L +R
Sbjct: 122 ACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAASADLKELCALELR 181
Query: 251 DWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPER 310
D+L D + EE +FE ++ W++ + + R+RY +ELFK +RL + P + + +
Sbjct: 182 DYLGD-DGLCGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDA 240
Query: 311 LVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEG 370
L+ ++ C +++ + +R GT + +P D ++++GG +
Sbjct: 241 LLQSSPAC-QIILETAKRQMFSL----CGTTVPDCKLLLHVPPRNSYQDFLILLGGRKDS 295
Query: 371 GDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFAKTVERYNP-- 428
+ + Y +W +L + L + +YV G M +++ +N
Sbjct: 296 QQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVSSGRSLVSHNVYI 355
Query: 429 ---NLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLE 485
LN W ++ ++S T K ++SIGG G + Y+ + W ++
Sbjct: 356 FSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESMA 415
Query: 486 SAP-KILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLID 544
S P +L A+A++D+ +Y+ D +I Y W +E+ +I
Sbjct: 416 SMPVGVLH--PAVAVKDQRLYLFG----GEDIMQNPVRLIQVYHISRNSWFKMET-RMIK 468
Query: 545 NYC 547
N C
Sbjct: 469 NVC 471
Score = 34.3 bits (77), Expect = 0.41
Identities = 28/126 (22%), Positives = 48/126 (38%), Gaps = 10/126 (7%)
Query: 380 YFVDEDRWVNLP-HIHNHLDGHAVAVTESYVYVAGSMEPGFAKTVERYNPNLNTWEHVCS 438
Y + + W + + ++ AV + E V V G + + + Y+P N +
Sbjct: 452 YHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGG-----YTRRILAYDPQSNKFVKCAD 506
Query: 439 LMTRKHSFGLTEVKGKLYSIGGHGNFS----PGFKDVTVYNPELDKWHNLESAPKILRDV 494
+ R+ G T + KLY GG + Y+PE D W + P L D
Sbjct: 507 MKDRRMHHGATVMGNKLYVTGGRRLTTDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDH 566
Query: 495 KALAIE 500
L ++
Sbjct: 567 ACLTLQ 572
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 155 bits (393), Expect = 9e-38
Identities = 116/491 (23%), Positives = 220/491 (44%), Gaps = 62/491 (12%)
Query: 94 CDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDT 153
CD+ L R+ AHR VLAAA+ +F + + ES+S VE++ EPD
Sbjct: 22 CDVILM---VQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKD------AEPDI 72
Query: 154 VEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAH 213
+E ++E+ YT RI V++ +V +L+ A+++ + +K+ C +FLK+++ SNC+ I LA
Sbjct: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
Query: 214 MYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKW 273
+L A D I ++F +V + +EF L + L+ +TV +E+ +++ ++W
Sbjct: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
Query: 274 VQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVADAVERHALRA 333
++ + R+ + ++ +R + +L++ V+ E L+ +N C+K+V + H L
Sbjct: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
Query: 334 EN---IQSGTCQHPTSHVSLLPRYGQNM-------------------------------- 358
E+ + GT H + +G +
Sbjct: 253 EDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW 312
Query: 359 -DVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEP 417
+V+ ++GG +C Y V +D W + D A E +Y +G E
Sbjct: 313 DNVVYILGGSQLFPIKRMDC--YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEV 370
Query: 418 GFAK--TVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGH-GNFSPG--FKDVT 472
G + E Y+ +W S++T++ S G+ E G +Y GG GN G
Sbjct: 371 GNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCE 430
Query: 473 VYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAV--ITCYDTE 530
VY+P + W L + ++ + ++D+ + ++GL + + YD +
Sbjct: 431 VYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGG--------QNGLGGLDNVEYYDIK 482
Query: 531 TRQWQDVESLP 541
+W+ V +P
Sbjct: 483 LNEWKMVSPMP 493
Score = 58.2 bits (139), Expect = 3e-08
Identities = 46/177 (25%), Positives = 74/177 (41%), Gaps = 17/177 (9%)
Query: 366 GVSEGGD---YLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAG-----SMEP 417
G SE G+ YL EC Y + W P + H + +YV G ++
Sbjct: 366 GGSEVGNSALYLFEC--YDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSG 423
Query: 418 GFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPE 477
+ E Y+P TW +C ++ + + GL VK K++++GG G +V Y+ +
Sbjct: 424 RVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLG-GLDNVEYYDIK 482
Query: 478 LDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQW 534
L++W + P VK A+ +A V G I Y+TET +W
Sbjct: 483 LNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGV------GRLGHILEYNTETDKW 533
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/227 (22%), Positives = 84/227 (37%), Gaps = 24/227 (10%)
Query: 426 YNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLE 485
+NP +W + ++ +Y +GG F K + YN D W++ +
Sbjct: 287 FNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP--IKRMDCYNVVKDSWYS-K 343
Query: 486 SAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDN 545
P RD A + +Y + + V + CYDT T W S ++
Sbjct: 344 LGPPTPRDSLAACAAEGKIYTSGGSEVGNSA----LYLFECYDTRTESWHTKPS--MLTQ 397
Query: 546 YCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIAS-QVSDEILES---LPPEVLSIEG 601
C M N Y C S L N + R + S +V D E+ L P + + +
Sbjct: 398 RCSHGMVEANGLIY----VCGGS--LGNNVSGRVLNSCEVYDPATETWTELCPMIEARKN 451
Query: 602 AAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMP 648
+ + KD +F +GG +D Y + W ++ PMP
Sbjct: 452 HGLVFVKDKIFAVGGQNGLGGLD-----NVEYYDIKLNEWKMVSPMP 493
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 154 bits (389), Expect = 3e-37
Identities = 139/567 (24%), Positives = 233/567 (41%), Gaps = 65/567 (11%)
Query: 18 LQVLEMESMETAAAGSAGLAAEVRGSGTVDFGPGPGISAMEASGGDPGPEAEDFECSSHC 77
LQ L++E ++ A G + +G +M +E+F + H
Sbjct: 145 LQELKVEPDNSSQATGEGCGHRLSSTG----------HSMTPQSDLDSSSSEEFYQAVHH 194
Query: 78 SELSWRQNEQR-RQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSG 136
+E ++R+ E +Q CD+ L G R+ AHR VL++ ++YF + + E++
Sbjct: 195 AEQTFRKMESYLKQQQLCDVILI---VGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQE 251
Query: 137 RVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFL 196
++M G +P+ + ++++ YTG + + ++ +L A L ++ E C FL
Sbjct: 252 EIKME------GIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFL 305
Query: 197 KKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDL 256
K LH SNC+ I + A +L A N +VI+++EF LP + L+
Sbjct: 306 MKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASD 365
Query: 257 EITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNE 316
++ V EE +F ++ WV+ + + R L +RL + P L ++ L N+
Sbjct: 366 DVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILA-DLENHALFKNDL 424
Query: 317 VCVKLVADAVERHAL--RAENIQSGTCQHPTSHVSLLPRYG-----------------QN 357
C KL+ +A++ H L R +QS + S V L G N
Sbjct: 425 ECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTN 484
Query: 358 M--------------------DVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHL 397
+ D + VIGG +G L+ Y W LP + H
Sbjct: 485 LWIQAGMMNGRRLQFGVAVIDDKLFVIGG-RDGLKTLNTVECYNPKTKTWTVLPPMSTHR 543
Query: 398 DGHAVAVTESYVYVAGSMEP-GFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLY 456
G V V E +Y G + + TVER++P W V S+ + + G+ + GKLY
Sbjct: 544 HGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLY 603
Query: 457 SIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDT 516
S+GG S + Y+P +KW+ K R +A D F+Y
Sbjct: 604 SVGGRDG-SSCLSSMEYYDPHTNKWNMCAPMCK-RRGGVGVATCDGFLYAVGGHDAPASN 661
Query: 517 E-DGLKAVITCYDTETRQWQDVESLPL 542
L + YD +T W V L +
Sbjct: 662 HCSRLLDYVERYDPKTDTWTMVAPLSM 688
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 153 bits (386), Expect = 6e-37
Identities = 110/427 (25%), Positives = 194/427 (45%), Gaps = 41/427 (9%)
Query: 71 FECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQF 130
F SS+ + N R+Q LF D+ L AG R F HR+VLAA + YF + SG
Sbjct: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLL---HAGNRTFPCHRAVLAACSRYFEAMFSGGL 79
Query: 131 SESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKE 190
ES+ V + P+ +E +++Y Y+ R+ ++ + +LE D +++
Sbjct: 80 KESQDSEVNF-----DNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRD 134
Query: 191 FCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIR 250
C EFL+K LH +NC+ + L+ + ++L + M NF + ++E+F LP ++
Sbjct: 135 ACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVV 194
Query: 251 DWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPER 310
LS E+ + E +++E+ + W+ + ++R Y EL + +RL+ + YL +V E
Sbjct: 195 QLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEE 254
Query: 311 LVANNEVCVKLVADAV--ERHALRAENIQSGTCQHP--TSHVSLLPRYGQNMDVIMVIGG 366
L+ ++V +A+ + L+ + + + C P T H + ++GG
Sbjct: 255 LITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGH------------ALFLLGG 302
Query: 367 VSEGGDYLSECVGYFVDEDRWVNLP--HIHNHLDGHAVAVTESYVYVAG--SMEPGFAKT 422
+ D L Y VD+ +P I + + VY+ G E G +K
Sbjct: 303 QTFMCDKL-----YLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKD 357
Query: 423 VERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGH--------GNFSPGFKDVTVY 474
V Y+ W ++ + G E+K LY +GGH + S K V Y
Sbjct: 358 VWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHY 417
Query: 475 NPELDKW 481
+P ++KW
Sbjct: 418 DPTINKW 424
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 1/128 (0%)
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA 420
+ GG S D L + Y E+RW A AV + +++ G A
Sbjct: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSA 505
Query: 421 KTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDK 480
+ ++N W V + ++ S KLY +GG+ K + Y+P LD
Sbjct: 506 CSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQ-RCKTLDCYDPTLDV 564
Query: 481 WHNLESAP 488
W+++ + P
Sbjct: 565 WNSITTVP 572
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 150 bits (380), Expect = 3e-36
Identities = 129/589 (21%), Positives = 247/589 (41%), Gaps = 48/589 (8%)
Query: 85 NEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 144
++ R++ CD+ + G + F H+SV+A+ +EYF +L + RV++ S
Sbjct: 64 SKMRQENFLCDLVI---GTKTKSFDVHKSVMASCSEYFYNILK---KDPSIQRVDLNDIS 117
Query: 145 SEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSN 204
P + VI Y YTG++ +S ++ ++ A + L + C +FL +++ + N
Sbjct: 118 ------PLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVEN 171
Query: 205 CVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEE 264
C+ + ++A Y+L A IR NF + + ++F L F I + L D ++ + SE
Sbjct: 172 CMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEI 231
Query: 265 VLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVAD 324
V F+ +KW++ + ++R +Y +L +R + L +V+ + + C +L+ D
Sbjct: 232 VAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVD 290
Query: 325 AVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIG---GVSEGGDYLSECVGYF 381
A+ H L H + S R V++ +G G++E LS + Y
Sbjct: 291 AMNYHLLP---------YHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKS--LSRDILYR 339
Query: 382 VDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFAKTVE--------RYNPNLNTW 433
E+ W L + VAV + ++YVAG + A+ RY+P NTW
Sbjct: 340 DPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTW 399
Query: 434 EHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRD 493
H+ S+ ++ F L+ G +Y+ GG N + Y P ++W ++ ++ R
Sbjct: 400 IHLASMNQKRTHFSLSVFNGLVYAAGGR-NAEGSLASLECYVPSTNQWQP-KTPLEVARC 457
Query: 494 VKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDNYCFFQMSV 553
A A+ D V + + + YD + WQ+ LP + + +V
Sbjct: 458 CHASAVADGRVLVTGGY-----IANAYSRSVCAYDPASDSWQE---LPNLSTPRGWHCAV 509
Query: 554 VNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIEGAAICYYKDDVFI 613
S+ E + + + P + + A + ++
Sbjct: 510 TLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYL 569
Query: 614 IGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVRIP 662
+GGW +K+Y+K + E W +P+ + C + +P
Sbjct: 570 VGGWNEG---EKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSMP 615
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 150 bits (378), Expect = 5e-36
Identities = 131/602 (21%), Positives = 253/602 (42%), Gaps = 45/602 (7%)
Query: 71 FECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQF 130
F ++H S + ++ R +GL CD+TL G G F HR+++A+A++YF + +G
Sbjct: 27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLV-PGDGDEIFPVHRAMMASASDYFKAMFTGGM 85
Query: 131 SESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKE 190
E +++ G ++ +I+++YT ++ ++ ++ + LE A ++ + +
Sbjct: 86 KEQDLMCIKLH------GVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLD 139
Query: 191 FCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIR 250
FC FL + L NCV + +A+ Y L ++ + I +NF ++ EF LPF +
Sbjct: 140 FCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLA 199
Query: 251 DWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPER 310
LS + +E LF+ +W+ R + R Y +L K +R M P L +V+
Sbjct: 200 FVLSSNSLKHCTELELFKAACRWL-RLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVD 258
Query: 311 LVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEG 370
+ + CV L+ L A N Q P + ++ + G + +
Sbjct: 259 FMRTDNTCVNLL--------LEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQ 310
Query: 371 GDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFAK------TVE 424
E Y W +L + H +AV +++YV G K TV
Sbjct: 311 LVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVF 370
Query: 425 RYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNL 484
R++P N W V SL ++ F L+ +KG LY++GG + + V YNP +++W +
Sbjct: 371 RFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGR-SAAGELATVECYNPRMNEWSYV 429
Query: 485 ESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLID 544
+ A + +YI+ T D + + C+D +T +W ++ P+
Sbjct: 430 AKMSE-PHYGHAGTVYGGLMYISGGI-----THDTFQNELMCFDPDTDKW--MQKAPMTT 481
Query: 545 NYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIEG--- 601
M V Y ++ + ++ + L+ P + G
Sbjct: 482 VRGLHCMCTVGDKLYVIGG----NHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSD 537
Query: 602 AAICYYKDDVFIIGG--WKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHV 659
+ +++ ++++GG W N ++ +Y E+ W + +P+ AC +
Sbjct: 538 VGVAVFENKIYVVGGYSWNNRCMVE-----IVQKYDPEKDEWHKVFDLPESLGGIRACTL 592
Query: 660 RI 661
+
Sbjct: 593 TV 594
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 149 bits (377), Expect = 7e-36
Identities = 123/483 (25%), Positives = 217/483 (44%), Gaps = 26/483 (5%)
Query: 70 DFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQ 129
+F H E+ N+QRR F D+ + GREF H++VLA+ + YF L+
Sbjct: 305 EFTDPGHPREMLKELNQQRRAKAFTDLKIV---VEGREFEVHQNVLASCSLYFKDLIQRS 361
Query: 130 FSES-RSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRL 188
+S + GR ++ S + D +E ++E++YTG + + + + +LE A +F
Sbjct: 362 VQDSGQGGREKLELVLSNL--QADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTF 419
Query: 189 KEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHL 248
+ C FL+K+L SNC+ + ++A S+L A + F +V EE ++
Sbjct: 420 CKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDD 479
Query: 249 IRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKP 308
++S+ + +EE+++ETV+KW++++ R +Y EL ++RL + P+YL V
Sbjct: 480 FIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
Query: 309 ERLVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNM-DVIMVIGGV 367
E L+ ++E C LV +A H L + Q P + PR + +VI+++GG
Sbjct: 540 EELIKSSEACRDLVNEAKRYHMLPHARQE---MQTPRTR----PRLSAGVAEVIVLVGGR 592
Query: 368 SEGGDYLSECVG---YFVDEDRWVNLPHIHNH-LDGHAVAVTESYVYVAGSMEPGFA-KT 422
G V + ++W L + + + +V +Y++G ME G
Sbjct: 593 QMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLAD 652
Query: 423 VERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWH 482
V Y L+ W V + + GK+Y++GG G + V Y+ ++W
Sbjct: 653 VWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLG-VAGNVDHVERYDTITNQWE 711
Query: 483 NLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPL 542
+ PK + A + R V+ Y +T W +ES P+
Sbjct: 712 AVAPLPKAVHSAAATVCGGKIYVFGGVNEAGR-----AAGVLQSYVPQTNTWSFIES-PM 765
Query: 543 IDN 545
IDN
Sbjct: 766 IDN 768
Score = 32.3 bits (72), Expect = 1.6
Identities = 31/132 (23%), Positives = 55/132 (41%), Gaps = 11/132 (8%)
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSM-EPGF 419
I +GG+ G+ + Y ++W + + + A V +YV G + E G
Sbjct: 685 IYTLGGLGVAGN-VDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGR 743
Query: 420 AKTV-ERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPEL 478
A V + Y P NTW + S M + G ++ +GG + T+Y+PE
Sbjct: 744 AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-----AYARATTIYDPEK 798
Query: 479 DKWHNLESAPKI 490
N+++ P +
Sbjct: 799 G---NIKAGPNM 807
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 149 bits (377), Expect = 7e-36
Identities = 123/483 (25%), Positives = 217/483 (44%), Gaps = 26/483 (5%)
Query: 70 DFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQ 129
+F H E+ N+QRR F D+ + GREF H++VLA+ + YF L+
Sbjct: 305 EFTDPGHPREMLKELNQQRRAKAFTDLKIV---VEGREFEVHQNVLASCSLYFKDLIQRS 361
Query: 130 FSES-RSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRL 188
+S + GR ++ S + D +E ++E++YTG + + + + +LE A +F
Sbjct: 362 VQDSGQGGREKLELVLSNL--QADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTF 419
Query: 189 KEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHL 248
+ C FL+K+L SNC+ + ++A S+L A + F +V EE ++
Sbjct: 420 CKVCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDD 479
Query: 249 IRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKP 308
++S+ + +EE+++ETV+KW++++ R +Y EL ++RL + P+YL V
Sbjct: 480 FIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
Query: 309 ERLVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNM-DVIMVIGGV 367
E L+ ++E C LV +A H L + Q P + PR + +VI+++GG
Sbjct: 540 EELIKSSEACRDLVNEAKRYHMLPHARQE---MQTPRTR----PRLSAGVAEVIVLVGGR 592
Query: 368 SEGGDYLSECVG---YFVDEDRWVNLPHIHNH-LDGHAVAVTESYVYVAGSMEPGFA-KT 422
G V + ++W L + + + +V +Y++G ME G
Sbjct: 593 QMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLAD 652
Query: 423 VERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWH 482
V Y L+ W V + + GK+Y++GG G + V Y+ ++W
Sbjct: 653 VWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLG-VAGNVDHVERYDTITNQWE 711
Query: 483 NLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPL 542
+ PK + A + R V+ Y +T W +ES P+
Sbjct: 712 AVAPLPKAVHSAAATVCGGKIYVFGGVNEAGR-----AAGVLQSYVPQTNTWSFIES-PM 765
Query: 543 IDN 545
IDN
Sbjct: 766 IDN 768
Score = 32.3 bits (72), Expect = 1.6
Identities = 31/132 (23%), Positives = 55/132 (41%), Gaps = 11/132 (8%)
Query: 361 IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSM-EPGF 419
I +GG+ G+ + Y ++W + + + A V +YV G + E G
Sbjct: 685 IYTLGGLGVAGN-VDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGR 743
Query: 420 AKTV-ERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPEL 478
A V + Y P NTW + S M + G ++ +GG + T+Y+PE
Sbjct: 744 AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG-----AYARATTIYDPEK 798
Query: 479 DKWHNLESAPKI 490
N+++ P +
Sbjct: 799 G---NIKAGPNM 807
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 148 bits (373), Expect = 2e-35
Identities = 130/602 (21%), Positives = 249/602 (41%), Gaps = 45/602 (7%)
Query: 71 FECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQF 130
F ++H S + ++ R +GL CD+TL G F HR ++A+A++YF + +G
Sbjct: 69 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDA-FPVHRVMMASASDYFKAMFTGGM 127
Query: 131 SESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKE 190
E +++ G + +I+++YT ++ ++ ++ + LE A ++ + +
Sbjct: 128 KEQDLMCIKLH------GVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLD 181
Query: 191 FCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIR 250
FC FL + L NCV + +A+ Y L+++ + +NF ++ EF LPF +
Sbjct: 182 FCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLA 241
Query: 251 DWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPER 310
LS + +E LF+ +W+ R E R + +L K +R M P L +V+
Sbjct: 242 FVLSSNSLKHCTELELFKATCRWL-RLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTVD 300
Query: 311 LVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEG 370
+ + CV L+ L A N Q P ++ + G + +
Sbjct: 301 FMRTDNTCVNLL--------LEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQ 352
Query: 371 GDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFAK------TVE 424
E Y W +L + H +AV +++YV G K TV
Sbjct: 353 LVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVF 412
Query: 425 RYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNL 484
R++P N W V SL ++ F L+ +KG LY++GG N + V YNP ++W +
Sbjct: 413 RFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGR-NAAGELPTVECYNPRTNEWTYV 471
Query: 485 ESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLID 544
+ A + +YI+ T D + + C+D +T +W ++ P+
Sbjct: 472 AKMSE-PHYGHAGTVYGGVMYISGGI-----THDTFQKELMCFDPDTDKW--IQKAPMTT 523
Query: 545 NYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIEG--- 601
M V Y ++ + ++ + IL+ P + G
Sbjct: 524 VRGLHCMCTVGERLYVIGG----NHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSD 579
Query: 602 AAICYYKDDVFIIGG--WKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHV 659
+ +++ ++++GG W N ++ +Y ++ W + +P+ AC +
Sbjct: 580 VGVAVFENKIYVVGGYSWNNRCMVE-----IVQKYDPDKDEWHKVFDLPESLGGIRACTL 634
Query: 660 RI 661
+
Sbjct: 635 TV 636
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 146 bits (368), Expect = 7e-35
Identities = 104/406 (25%), Positives = 181/406 (44%), Gaps = 21/406 (5%)
Query: 131 SESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKE 190
SESR+ RV +++ T+ +I+Y+YT I+V+ +V +L A L +K+
Sbjct: 2 SESRAKRVRIKEVDGW------TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK 55
Query: 191 FCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEFYTLPFHLIR 250
C EFL+ +LH NC+ I + A M+ + L KA ++F V+ EEF L +
Sbjct: 56 TCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVC 115
Query: 251 DWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPER 310
+S ++T+ SEE +FE V+ WV + + R+ + L + +RL + YL + V+ E
Sbjct: 116 SLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEA 175
Query: 311 LVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIM-VIGGVSE 369
LV N+ C + +A++ H L E + V R N+ +M V+GG +
Sbjct: 176 LVKNSSACKDYLIEAMKYHLLPTEQ------RILMKSVRTRLRTPMNLPKLMVVVGGQAP 229
Query: 370 GGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF-AKTVERYNP 428
EC Y E+RW + + + + V+ G +TV+ Y+P
Sbjct: 230 KAIRSVEC--YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDP 287
Query: 429 NLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAP 488
+ W V ++ R+ + G + G LY++GG S G V YN + ++W ++
Sbjct: 288 VKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDG-STGLSSVEAYNIKSNEWFHVAPMN 346
Query: 489 KILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQW 534
V + + R + + CY+ T +W
Sbjct: 347 TRRSSVGVGVVGGLLYAVGGYDGASRQ----CLSTVECYNATTNEW 388
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 4/128 (3%)
Query: 376 ECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSME-PGFAKTVERYNPNLNTWE 434
EC Y + W + + G V V + +Y G + P K+VE Y+P N W
Sbjct: 379 EC--YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWR 436
Query: 435 HVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDV 494
V + + + G+ V G LY +GG S V YNP DKW + S R
Sbjct: 437 QVADMNMCRRNAGVCAVNGLLYVVGGDDG-SCNLASVEYYNPTTDKWTVVSSCMSTGRSY 495
Query: 495 KALAIEDR 502
+ + D+
Sbjct: 496 AGVTVIDK 503
Score = 57.8 bits (138), Expect = 3e-08
Identities = 43/183 (23%), Positives = 75/183 (40%), Gaps = 11/183 (6%)
Query: 360 VIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF 419
++ +GG +G LS Y + + W ++ ++ V V +Y G +
Sbjct: 313 LLYAVGGF-DGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGAS 371
Query: 420 AK---TVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNP 476
+ TVE YN N W ++ + TR+ G+ + LY++GGH K V VY+P
Sbjct: 372 RQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG-PLVRKSVEVYDP 430
Query: 477 ELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQD 536
+ W + R+ A+ + +Y+ V D A + Y+ T +W
Sbjct: 431 TTNAWRQVADMNMCRRNAGVCAV-NGLLYV-----VGGDDGSCNLASVEYYNPTTDKWTV 484
Query: 537 VES 539
V S
Sbjct: 485 VSS 487
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 146 bits (368), Expect = 7e-35
Identities = 125/503 (24%), Positives = 221/503 (43%), Gaps = 46/503 (9%)
Query: 75 SHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESR 134
SH + N+QR G+ CDITL A ++F AH++VLAA ++YF + S ES
Sbjct: 23 SHNDSVLAALNQQRSDGILCDITLI---AEEQKFHAHKAVLAACSDYFRAMFSLCMVESG 79
Query: 135 SGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGE 194
+ V + G ++ +E+ YTG+I + G + +VL L+ L C
Sbjct: 80 ADEVNLH------GVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSH 133
Query: 195 FLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQD--EEFYTLPFHLIRDW 252
+L ++L+ N + ++ LA ++ L+ L D + ++ ++++ EE TLP+ L+++
Sbjct: 134 YLIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEV 193
Query: 253 LSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLV 312
L +T SEE +++ ++W++ N +Y +EL + +R M L LV
Sbjct: 194 LKSDRLTSLSEEQIWQLAVRWLEHNC--HYQYMDELLQYIRFGLMDVDTLHTVALSHPLV 251
Query: 313 ANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEGGD 372
+E LV +A+E H QS Q PR+ D + +IGG
Sbjct: 252 QASETATALVNEALEYH-------QSIYAQPVWQTRRTKPRF--QSDTLYIIGGKKREVC 302
Query: 373 YLSECVGYF--VDED--------RWVNLPHIHNHLDGHAVAVTESYVYVAG------SME 416
+ E + YF VD++ W L + H VAV +++VAG S
Sbjct: 303 KVKE-LRYFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGR 361
Query: 417 PGFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNP 476
+T RY+P N+W + + + F L ++ LY++GG V Y P
Sbjct: 362 TCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCP 421
Query: 477 ELDKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQD 536
+ +KW ++S + L A + D ++I+ ++ L Y+ +W
Sbjct: 422 KKNKWTFVQSFDRSL-SCHAGYVADGLLWISGGVTNTAQYQNRLMV----YEPNQNKW-- 474
Query: 537 VESLPLIDNYCFFQMSVVNSNFY 559
+ P++ + M+ V Y
Sbjct: 475 ISRSPMLQRRVYHSMAAVQRKLY 497
Score = 43.5 bits (101), Expect = 7e-04
Identities = 29/133 (21%), Positives = 56/133 (42%), Gaps = 6/133 (4%)
Query: 355 GQNMDVIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGS 414
G + + +GG +E L Y +++W + L HA V + ++++G
Sbjct: 394 GAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGG 453
Query: 415 ME--PGFAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGG----HGNFSPGF 468
+ + + Y PN N W ++ R+ + V+ KLY +GG + N
Sbjct: 454 VTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILV 513
Query: 469 KDVTVYNPELDKW 481
+ + YN + D+W
Sbjct: 514 RHIDSYNIDTDQW 526
Score = 40.8 bits (94), Expect = 0.004
Identities = 21/109 (19%), Positives = 54/109 (49%), Gaps = 7/109 (6%)
Query: 360 VIMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGF 419
++ + GGV+ Y + + Y ++++W++ + H++A + +YV G + +
Sbjct: 447 LLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDY 506
Query: 420 ------AKTVERYNPNLNTWEHV-CSLMTRKHSFGLTEVKGKLYSIGGH 461
+ ++ YN + + W +L+T ++ G+ G++Y +GG+
Sbjct: 507 NNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLVGGY 555
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 144 bits (363), Expect = 3e-34
Identities = 140/602 (23%), Positives = 257/602 (42%), Gaps = 48/602 (7%)
Query: 71 FECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQF 130
+ + H S + R NEQR +GLFCD+ L A + AHR++LA ++YF + +
Sbjct: 23 YRWADHSSTVLQRLNEQRLRGLFCDVVLV---ADEQRVPAHRNLLAVCSDYFNSMFTIGM 79
Query: 131 SESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKE 190
E+ VE+ G ++AV++++Y G + + G++ VLE A + + +
Sbjct: 80 REAFQKEVELI------GASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVD 133
Query: 191 FCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEEF-YTLPFHLI 249
FC E+L++++ N + + LA +Y+L +L I +F + +F + +
Sbjct: 134 FCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKL 193
Query: 250 RDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPE 309
+LS E+ + E L + L+W+ + ERE + ++ + + + L VKP
Sbjct: 194 CVYLSSSEVQRECEHDLLQAALQWLTQQ-PEREAHARQVLENIHFPLIPKNDLLHRVKPA 252
Query: 310 --RLVANNEVCVKLVADAVERH-ALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGG 366
L+ C + +AV H L A+ + T +L N + ++ +GG
Sbjct: 253 VCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQ------TKRTAL----RTNQERLLFVGG 302
Query: 367 -VSEGGDYLSECVGYF-VDEDRWVNLPHIHNHLDGHAVAVTESYVYVAG---SMEPG--- 418
VSE LS+ Y ++WV + H VAV ++++AG S + G
Sbjct: 303 EVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDA 362
Query: 419 FAKTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPEL 478
+ + RY+P W V S+ R+ F L ++ L +IGG N + V Y+P+
Sbjct: 363 ASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGR-NENGALSSVETYSPKT 421
Query: 479 DKWHNLESAPKILRDVKALAIEDRFVYIAARTPVDRDTEDG-LKAVITCYDTETRQWQDV 537
D W + P+ +D FVYI+ D + G + + CYD T W+
Sbjct: 422 DSWSYVAGLPRFTYGHAGTIYKD-FVYISG----GHDYQIGPYRKNLLCYDHRTDVWE-- 474
Query: 538 ESLPLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVL 597
E P+ + M + + Y +E + + A + P +
Sbjct: 475 ERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLH 534
Query: 598 SIEGAAICYYKDDVFIIGG--WKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRAT 655
+ + + ++ ++I+GG W+N+ + K Y E +W +P+ +
Sbjct: 535 ANSESGVAVWEGRIYILGGYSWENT-----AFSKTVQVYDREADKWSRGVDLPKAIAGGS 589
Query: 656 AC 657
AC
Sbjct: 590 AC 591
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,773,628
Number of Sequences: 37866
Number of extensions: 1382039
Number of successful extensions: 7111
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 147
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 5681
Number of HSP's gapped (non-prelim): 717
length of query: 708
length of database: 18,247,518
effective HSP length: 109
effective length of query: 599
effective length of database: 14,120,124
effective search space: 8457954276
effective search space used: 8457954276
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.