Search of human proteins with 8670546

Search of human proteins with 8670546

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
         (400 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       816   0.0  
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     809   0.0  
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       693   0.0  
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     686   0.0  
gi|4758968 cytohesin 3 [Homo sapiens]                                 666   0.0  
gi|7019505 cytohesin 4 [Homo sapiens]                                 578   e-165
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   187   1e-47
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   179   5e-45
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      167   1e-41
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]       167   1e-41
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 160   2e-39
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]       153   3e-37
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]       153   3e-37
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   144   1e-34
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    111   1e-24
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      110   3e-24
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...   109   5e-24
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...   109   5e-24
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]    107   1e-23
gi|48928044 F-box only protein 8 [Homo sapiens]                        93   4e-19
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    62   1e-09
gi|239047795 pleckstrin homology domain containing, family A mem...    61   2e-09
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...    55   1e-07
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    54   3e-07
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H...    53   6e-07
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit...    52   7e-07
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]        50   3e-06
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]       50   3e-06
gi|187608516 centaurin, beta 2 [Homo sapiens]                          50   4e-06
gi|50234893 pleckstrin homology domain containing, family A (pho...    50   4e-06

>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  816 bits (2108), Expect = 0.0
 Identities = 400/400 (100%), Positives = 400/400 (100%)

Query: 1   MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ 60
           MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
Sbjct: 1   MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ 60

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE 120
           RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
Sbjct: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE 120

Query: 121 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ 180
           LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
Sbjct: 121 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ 180

Query: 181 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN 240
           STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
Sbjct: 181 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN 240

Query: 241 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP 300
           EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP
Sbjct: 241 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP 300

Query: 301 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT 360
           RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
Sbjct: 301 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT 360

Query: 361 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP 400
           QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
Sbjct: 361 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP 400


>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  809 bits (2090), Expect = 0.0
 Identities = 399/400 (99%), Positives = 399/400 (99%), Gaps = 1/400 (0%)

Query: 1   MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ 60
           MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
Sbjct: 1   MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ 60

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE 120
           RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
Sbjct: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE 120

Query: 121 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ 180
           LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
Sbjct: 121 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ 180

Query: 181 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN 240
           STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
Sbjct: 181 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN 240

Query: 241 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP 300
           EPFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKEP
Sbjct: 241 EPFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKEP 299

Query: 301 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT 360
           RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
Sbjct: 300 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT 359

Query: 361 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP 400
           QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
Sbjct: 360 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP 399


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  693 bits (1789), Expect = 0.0
 Identities = 329/395 (83%), Positives = 366/395 (92%)

Query: 2   EDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQR 61
           ED  Y P DLT EER ELENIRRRKQELL +IQRL++E++E  +E+E L + E  K +QR
Sbjct: 3   EDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQR 62

Query: 62  NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREEL 121
           N+++AMGRKKFNMDPKKGIQFL+EN+LL+NT E+IA+FLYKGEGLNKTAIGDYLGER+E 
Sbjct: 63  NKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEF 122

Query: 122 NLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQS 181
           N+ VLHAFV+LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC CN GVFQS
Sbjct: 123 NIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQS 182

Query: 182 TDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNE 241
           TDTCYVLSFA+IMLNTSLHNPNV+DKP +ERF+AMNRGIN+GGDLPEELLRNLY+SI+NE
Sbjct: 183 TDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNE 242

Query: 242 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 301
           PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
Sbjct: 243 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 302

Query: 302 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ 361
           GIIPLENLSIREV+D +KPNCFELYIP+NK Q+IKACKTEADGRVVEGNH VYRISAPT 
Sbjct: 303 GIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTP 362

Query: 362 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKK 396
           EEK+EWIK I+AA+S DPFYEMLAARKK++S  K+
Sbjct: 363 EEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKR 397


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  686 bits (1771), Expect = 0.0
 Identities = 328/395 (83%), Positives = 365/395 (92%), Gaps = 1/395 (0%)

Query: 2   EDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQR 61
           ED  Y P DLT EER ELENIRRRKQELL +IQRL++E++E  +E+E L + E  K +QR
Sbjct: 3   EDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQR 62

Query: 62  NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREEL 121
           N+++AMGRKKFNMDPKKGIQFL+EN+LL+NT E+IA+FLYKGEGLNKTAIGDYLGER+E 
Sbjct: 63  NKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEF 122

Query: 122 NLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQS 181
           N+ VLHAFV+LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC CN GVFQS
Sbjct: 123 NIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQS 182

Query: 182 TDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNE 241
           TDTCYVLSFA+IMLNTSLHNPNV+DKP +ERF+AMNRGIN+GGDLPEELLRNLY+SI+NE
Sbjct: 183 TDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNE 242

Query: 242 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 301
           PFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
Sbjct: 243 PFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 301

Query: 302 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ 361
           GIIPLENLSIREV+D +KPNCFELYIP+NK Q+IKACKTEADGRVVEGNH VYRISAPT 
Sbjct: 302 GIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTP 361

Query: 362 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKK 396
           EEK+EWIK I+AA+S DPFYEMLAARKK++S  K+
Sbjct: 362 EEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKR 396


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  666 bits (1719), Expect = 0.0
 Identities = 321/398 (80%), Positives = 365/398 (91%), Gaps = 5/398 (1%)

Query: 2   EDGVYE----PPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSK 57
           EDG  E    P DL+ EER EL +IRRRK+EL+ +I+RL+ E++E M+E++ L + E SK
Sbjct: 3   EDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESK 62

Query: 58  TLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE 117
           T QRN+++AMGRKKFNMDPKKGIQFL+EN+LLQ++PE++A+FLYKGEGLNKT IGDYLGE
Sbjct: 63  TTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGE 122

Query: 118 REELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG 177
           R+E N+ VL AFV+LHEF DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPG
Sbjct: 123 RDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPG 182

Query: 178 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS 237
           VFQSTDTCYVLSFA+IMLNTSLHN NVRDKP  ERF+AMNRGINEGGDLPEELLRNLY+S
Sbjct: 183 VFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYES 242

Query: 238 IRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTD 297
           I+NEPFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTD
Sbjct: 243 IKNEPFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTD 301

Query: 298 KEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRIS 357
           KEPRGIIPLENLSIREV+DPRKPNCFELY P++KGQ+IKACKTEADGRVVEGNH+VYRIS
Sbjct: 302 KEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRIS 361

Query: 358 APTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKK 395
           AP+ EEK+EW+KSI+A++S DPFY+MLA RK+RI+ KK
Sbjct: 362 APSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK 399


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  578 bits (1490), Expect = e-165
 Identities = 270/389 (69%), Positives = 335/389 (86%), Gaps = 1/389 (0%)

Query: 7   EPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMA 66
           EP +L+  E  EL+ I+  +++LL +IQ+L++E+++  ++++  E+ E S+  Q+ +++ 
Sbjct: 7   EPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELC 66

Query: 67  MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVL 126
           +GRKKFNMDP KGIQ+ +E++LL    ++IARFLYKGEGLNKTAIG YLGER+ +NL VL
Sbjct: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVL 126

Query: 127 HAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCY 186
            AFVD HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPGVFQSTDTCY
Sbjct: 127 QAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCY 186

Query: 187 VLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP 246
           VLSF++IMLNTSLHNPNVRD+P  ERFV+MNRGIN G DLPE+ LRNL+DSI++EPF IP
Sbjct: 187 VLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIP 246

Query: 247 EDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPL 306
           EDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPL
Sbjct: 247 EDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPL 305

Query: 307 ENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDE 366
           ENLS+++VDDP+KP C ELY P+ +GQ IKACKT+ DGRVVEG H  YRISA + EE+D+
Sbjct: 306 ENLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQ 365

Query: 367 WIKSIQAAVSVDPFYEMLAARKKRISVKK 395
           WI+SI+A+++  PFY++++ RKK+I+ K+
Sbjct: 366 WIESIRASITRVPFYDLVSTRKKKIASKQ 394


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  187 bits (475), Expect = 1e-47
 Identities = 93/206 (45%), Positives = 140/206 (67%), Gaps = 3/206 (1%)

Query: 45  SEVEGLEANEGSKTLQRNRKMA-MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKG 103
           +++ G +  E  + L++ +++   G   FN  PK+GIQ+L E  +L  TPE+IA+FL++ 
Sbjct: 681 TQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQE 740

Query: 104 EGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRM 163
           E L+ T +G++LG+ ++ N  V++A+VD H+F+  + V ALR FL  FRLPGEAQKIDR+
Sbjct: 741 ERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRL 800

Query: 164 MEAFAQRYCLCNPG--VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGIN 221
           ME FA RY  CN G  +F S DT YVL++++IML T LH+P V++K   E+++ MNRGIN
Sbjct: 801 MEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGIN 860

Query: 222 EGGDLPEELLRNLYDSIRNEPFKIPE 247
           +  DLPEE L  +Y+ I  +   + E
Sbjct: 861 DSKDLPEEYLSAIYNEIAGKKISMKE 886


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  179 bits (453), Expect = 5e-45
 Identities = 90/190 (47%), Positives = 127/190 (66%), Gaps = 2/190 (1%)

Query: 60  QRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE 119
           Q+   +  G + FN  PK+GIQFL E  +L  + E+IA+FL++ E L+ T +GD+LG+  
Sbjct: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701

Query: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG-- 177
             N  V++A+VD  +F +   V ALR FL  FRLPGEAQKIDR+ME FA RY  CN G  
Sbjct: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761

Query: 178 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS 237
           +F S DT YVL++++IML T LH+P V++K   E+++ MNRGIN+  DLPEE L ++Y+ 
Sbjct: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821

Query: 238 IRNEPFKIPE 247
           I  +   + E
Sbjct: 822 IEGKKIAMKE 831


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  167 bits (424), Expect = 1e-41
 Identities = 84/199 (42%), Positives = 132/199 (66%), Gaps = 6/199 (3%)

Query: 56  SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL 115
           S  + R R   +G   FN  P+KG+Q+L+E   + +TP  +A FL + +GL++  IG++L
Sbjct: 505 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL 564

Query: 116 GERE-ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLC 174
           G R+ + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+C
Sbjct: 565 GNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCIC 624

Query: 175 NPGV---FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEE 229
           NPGV   F++ DT ++L+FA+I+LNT +++PNV+   K  LE F+   RG+++G D+P E
Sbjct: 625 NPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRE 684

Query: 230 LLRNLYDSIRNEPFKIPED 248
           +L  +Y+ IR    K  ED
Sbjct: 685 MLMGIYERIRKRELKTNED 703


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score =  167 bits (424), Expect = 1e-41
 Identities = 84/199 (42%), Positives = 132/199 (66%), Gaps = 6/199 (3%)

Query: 56  SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL 115
           S  + R R   +G   FN  P+KG+Q+L+E   + +TP  +A FL + +GL++  IG++L
Sbjct: 519 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL 578

Query: 116 GERE-ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLC 174
           G R+ + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+C
Sbjct: 579 GNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCIC 638

Query: 175 NPGV---FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEE 229
           NPGV   F++ DT ++L+FA+I+LNT +++PNV+   K  LE F+   RG+++G D+P E
Sbjct: 639 NPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRE 698

Query: 230 LLRNLYDSIRNEPFKIPED 248
           +L  +Y+ IR    K  ED
Sbjct: 699 MLMGIYERIRKRELKTNED 717


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  160 bits (404), Expect = 2e-39
 Identities = 80/194 (41%), Positives = 129/194 (66%), Gaps = 6/194 (3%)

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE-RE 119
           R R   +G   FN++P KGIQFL+    + +TP  +A FL + +GL++  IG++LG  ++
Sbjct: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407

Query: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178
           + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+CNP V 
Sbjct: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467

Query: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEELLRNL 234
             F + DT ++L+FA+I+LNT +++PN++   K  LE F+   RG+++G D+P EL+  +
Sbjct: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527

Query: 235 YDSIRNEPFKIPED 248
           Y+ I+ +  K  ED
Sbjct: 528 YERIQQKELKSNED 541


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score =  153 bits (386), Expect = 3e-37
 Identities = 76/194 (39%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE- 119
           + R   +G   FN  P+KGIQ+L+E   L +TP  +A F+ + +GL++  IG++LG R+ 
Sbjct: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607

Query: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178
           + N  VL   VD  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC+CNP + 
Sbjct: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667

Query: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVR--DKPGLERFVAMNRGINEGGDLPEELLRNL 234
             F++ DT ++L+FA+I+LNT +++P+V+   K  L+ F+   RG++ G D+P +LL  +
Sbjct: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727

Query: 235 YDSIRNEPFKIPED 248
           Y  I+    +  +D
Sbjct: 728 YQRIQGRELRTNDD 741


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score =  153 bits (386), Expect = 3e-37
 Identities = 76/194 (39%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE- 119
           + R   +G   FN  P+KGIQ+L+E   L +TP  +A F+ + +GL++  IG++LG R+ 
Sbjct: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812

Query: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178
           + N  VL   VD  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC+CNP + 
Sbjct: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872

Query: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVR--DKPGLERFVAMNRGINEGGDLPEELLRNL 234
             F++ DT ++L+FA+I+LNT +++P+V+   K  L+ F+   RG++ G D+P +LL  +
Sbjct: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932

Query: 235 YDSIRNEPFKIPED 248
           Y  I+    +  +D
Sbjct: 933 YQRIQGRELRTNDD 946


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  144 bits (363), Expect = 1e-34
 Identities = 80/195 (41%), Positives = 122/195 (62%), Gaps = 11/195 (5%)

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELL----QNTPEEIARFLYKGEGLNKTAIGDYLG 116
           + + +  G ++FN  PKKGIQFL E  LL     NT  E+A++L +   L+K  IG+++ 
Sbjct: 699 KKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNT--EVAQWLRENPRLDKKMIGEFVS 756

Query: 117 EREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNP 176
           +R+ ++L  L +FV    F  L L +ALR +L +FRLPGEA  I R++EAF +R+  CN 
Sbjct: 757 DRKNIDL--LESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNG 814

Query: 177 GVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPG---LERFVAMNRGINEGGDLPEELLRN 233
             F ++D C+ L++AVIMLNT  HN NVR +     LE F    +G+N G D  +++L +
Sbjct: 815 SPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILED 874

Query: 234 LYDSIRNEPFKIPED 248
           +Y +I+NE   +PE+
Sbjct: 875 MYHAIKNEEIVMPEE 889


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  111 bits (277), Expect = 1e-24
 Identities = 91/343 (26%), Positives = 150/343 (43%), Gaps = 74/343 (21%)

Query: 96  IARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG 155
           +A  LY+ EG  K+ +  YL +  + + AV   ++   +F   +L +ALR FL +  L G
Sbjct: 591 LASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSG 650

Query: 156 EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVA 215
           E Q+ +R++  F++R+  CNPG+F S D+ + L+ A+++LNT LH  N+      + F+ 
Sbjct: 651 ETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFIT 710

Query: 216 MNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPD-------------- 261
              G+ +GG+ P+ELL+ LY SIR+E  +   D+ +        P               
Sbjct: 711 NLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLA 770

Query: 262 --------REGWLLKL----GGGRVKTW-KRRW----FILTDNCLYYFEYTTDKEPRGII 304
                   ++G L +       G+   W KR W     +L    LY+ +   D    G  
Sbjct: 771 QDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEG-- 828

Query: 305 PLENLSIREVDDP---------------RKPNCFELYIPNNKGQLIKACKTEADGRVVEG 349
             E+L  + VD+P               +KP+ F+L                AD R    
Sbjct: 829 --ESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQL--------------RTADWR---- 868

Query: 350 NHMVYRISAPTQEEKDEWIKSIQAAV---SVDPFYEMLAARKK 389
              +Y   APT +E   WI  I  A    S  PF   + ++++
Sbjct: 869 ---LYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRR 908


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  110 bits (274), Expect = 3e-24
 Identities = 56/156 (35%), Positives = 88/156 (56%)

Query: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153
           + +A+ LY+ +G  K  +  +LG+  + +  V   ++    FT + L QALR FL    L
Sbjct: 559 QRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELAL 618

Query: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213
            GE Q+ +R++  F+QRY  CNP    S D  + L+ A+++LNT LH  N+  +     F
Sbjct: 619 MGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678

Query: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249
           +    G+N+GGD P ELL+ LY SI+NE  +   D+
Sbjct: 679 IGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score =  109 bits (272), Expect = 5e-24
 Identities = 54/156 (34%), Positives = 92/156 (58%)

Query: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153
           + +A+ LY+ +   ++ +  +LG+  E +  V   ++   +FT + L Q+LR F  +F L
Sbjct: 52  KRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSL 111

Query: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213
            GE Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH  N+  K   + F
Sbjct: 112 VGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 171

Query: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249
           +A  +G+NEG D  ++LL+ LY+SI+NE  +   DD
Sbjct: 172 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score =  109 bits (272), Expect = 5e-24
 Identities = 54/156 (34%), Positives = 92/156 (58%)

Query: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153
           + +A+ LY+ +   ++ +  +LG+  E +  V   ++   +FT + L Q+LR F  +F L
Sbjct: 586 KRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSL 645

Query: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213
            GE Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH  N+  K   + F
Sbjct: 646 VGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 705

Query: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249
           +A  +G+NEG D  ++LL+ LY+SI+NE  +   DD
Sbjct: 706 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score =  107 bits (268), Expect = 1e-23
 Identities = 58/156 (37%), Positives = 92/156 (58%), Gaps = 2/156 (1%)

Query: 96  IARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG 155
           +AR LY  EG  +  +   LG+  E +  V   ++   +F+ L L  ALR FL +F L G
Sbjct: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376

Query: 156 EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVA 215
           E Q+ +R++  F++RYC CNP    S D  + L+ A+++LNT LH  N+  K   ++F+A
Sbjct: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436

Query: 216 MNRGINEGGDLPEELLRNLYDSIRNEPFK--IPEDD 249
               +N+G D  ++LL+ LY+SI+NE  +  I ED+
Sbjct: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 54/176 (30%), Positives = 95/176 (53%), Gaps = 11/176 (6%)

Query: 68  GRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLH 127
           G   FN +P +G+ + +   +L ++P+EIA+F++    LN   +  YL ER +    VL 
Sbjct: 142 GSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRD----VLD 197

Query: 128 AFVDLHEFTDLNLVQALRQFLWSFRLPGE-AQKIDRMMEAFAQRYCLCNPGVFQ----ST 182
             V LH F +  L  ALR+F      P E  + ++ ++  F+ R+C CNP + +    S 
Sbjct: 198 DLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSP 257

Query: 183 DTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSI 238
           D  YVL +++I+L+  L +P+V++K     F+   R      ++ E+ + +LYD+I
Sbjct: 258 DAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 38/112 (33%), Positives = 54/112 (48%), Gaps = 11/112 (9%)

Query: 264 GWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCF 323
           GWL K GG  VKTW  RWF+L  + LYYF+   + +P G I L    + E        C 
Sbjct: 24  GWLRKQGGF-VKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSE------HPCN 76

Query: 324 ELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAV 375
           E     N G+ +       D   +  NH  Y + A TQ + ++W+KSI+  +
Sbjct: 77  E----ENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVI 124


>gi|239047795 pleckstrin homology domain containing, family A member
           7 [Homo sapiens]
          Length = 1121

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 1/115 (0%)

Query: 264 GWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV-DDPRKPNC 322
           GWL K     ++ WKRRWF+L D CL+Y++ + ++   G IPL +  I  V  + R    
Sbjct: 169 GWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRK 228

Query: 323 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSV 377
           +     +   + +    + A  +  +     Y  SA TQE+ + W++++  A  V
Sbjct: 229 YSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV 283


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 18/116 (15%)

Query: 262 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPN 321
           + GWL K     VK W +RWF+L D CL+Y++   ++   G IPL +  +  V       
Sbjct: 62  KAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQ------ 115

Query: 322 CFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSV 377
                 P++        K E  G         Y  SA + EE++ WI+++  A  V
Sbjct: 116 ------PSDNISRKHTFKAEHAG------VRTYFFSAESPEEQEAWIQAMGEAARV 159


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 38/138 (27%), Positives = 63/138 (45%), Gaps = 23/138 (16%)

Query: 262 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPN 321
           ++G+L K G  R + W  RWF L  +CL YF     KE RGIIPL+             +
Sbjct: 219 KQGYLWKRGHLR-RNWAERWFQLQPSCLCYFGSEECKEKRGIIPLD------------AH 265

Query: 322 CFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFY 381
           C    +P+  G+    C        V+  +  Y +SA    ++ EW  +IQ A+ +    
Sbjct: 266 CCVEVLPDRDGKRCMFC--------VKTANRTYEMSASDTRQRQEWTAAIQMAIRLQA-- 315

Query: 382 EMLAARKKRISVKKKQEQ 399
           E   +  K +  K+++++
Sbjct: 316 EGKTSLHKDLKQKRREQR 333



 Score = 29.3 bits (64), Expect = 6.6
 Identities = 14/38 (36%), Positives = 24/38 (63%)

Query: 14  EERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLE 51
           E+R + E  R  K+E L+ +Q+L+EE    + E+E L+
Sbjct: 331 EQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQ 368


>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
           sapiens]
          Length = 713

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 25/69 (36%), Positives = 38/69 (55%), Gaps = 3/69 (4%)

Query: 260 PDREGWLLKL---GGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDD 316
           PD +GWLL     GG     W+RRWF+L  + LY++    D++  G+I + N S+    D
Sbjct: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456

Query: 317 PRKPNCFEL 325
            +K   F+L
Sbjct: 457 QKKKYVFQL 465


>gi|158631203 dual adaptor of phosphotyrosine and
           3-phosphoinositides [Homo sapiens]
          Length = 280

 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 39/116 (33%), Positives = 50/116 (43%), Gaps = 24/116 (20%)

Query: 262 REGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVD-DPRKP 320
           +EG+L K GG  VKTWK RWF L  N L YF+     EP  I+ L   S  + D    + 
Sbjct: 167 KEGYLTKQGG-LVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERV 225

Query: 321 NCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVS 376
           NCF L  P                         + + A T  E DEWIK ++  +S
Sbjct: 226 NCFCLVFP----------------------FRTFYLCAKTGVEADEWIKILRWKLS 259


>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 35/117 (29%), Positives = 58/117 (49%), Gaps = 24/117 (20%)

Query: 262 REGWLLKLGGGRVKTWKRRWFIL--TDNCLYYFEYTTDK-EPRGIIPLENLSIREVDDPR 318
           ++G+LLK G G  K WK  +FIL  +D  L YFE      +P+G+I L   S+  V D  
Sbjct: 477 KKGYLLKKGKG--KRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSL 534

Query: 319 --KPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQA 373
             +PNCF++ + +   +                 H ++  +  T E+ ++W+K +QA
Sbjct: 535 FGRPNCFQIVVQHFSEE-----------------HYIFYFAGETPEQAEDWMKGLQA 574


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 35/117 (29%), Positives = 58/117 (49%), Gaps = 24/117 (20%)

Query: 262 REGWLLKLGGGRVKTWKRRWFIL--TDNCLYYFEYTTDK-EPRGIIPLENLSIREVDDPR 318
           ++G+LLK G G  K WK  +FIL  +D  L YFE      +P+G+I L   S+  V D  
Sbjct: 300 KKGYLLKKGKG--KRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSL 357

Query: 319 --KPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQA 373
             +PNCF++ + +   +                 H ++  +  T E+ ++W+K +QA
Sbjct: 358 FGRPNCFQIVVQHFSEE-----------------HYIFYFAGETPEQAEDWMKGLQA 397


>gi|187608516 centaurin, beta 2 [Homo sapiens]
          Length = 778

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 29/114 (25%), Positives = 51/114 (44%), Gaps = 22/114 (19%)

Query: 263 EGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNC 322
           EG+L K      KTW RRWF + +N L Y +   D     +  L   +++  +D  +  C
Sbjct: 270 EGYLFKRASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFC 329

Query: 323 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVS 376
           FE+  P       K+C  +AD                +++ +  WIK++Q +++
Sbjct: 330 FEVVSPT------KSCMLQAD----------------SEKLRQAWIKAVQTSIA 361


>gi|50234893 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 31/121 (25%), Positives = 59/121 (48%), Gaps = 23/121 (19%)

Query: 260 PDREGWLLKLG-----GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV 314
           P ++  ++K G     G  +K WKRR+F L +N + YF+   +KEP  +IPL     +EV
Sbjct: 186 PPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPL-----KEV 240

Query: 315 DDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAA 374
              ++    ++ + +N  +++   +T             + + A + EE   WIK++  A
Sbjct: 241 HKVQECKQSDIMMRDNLFEIVTTSRT-------------FYVQADSPEEMHSWIKAVSGA 287

Query: 375 V 375
           +
Sbjct: 288 I 288


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,848,694
Number of Sequences: 37866
Number of extensions: 722544
Number of successful extensions: 3404
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 3033
Number of HSP's gapped (non-prelim): 493
length of query: 400
length of database: 18,247,518
effective HSP length: 104
effective length of query: 296
effective length of database: 14,309,454
effective search space: 4235598384
effective search space used: 4235598384
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.