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Search of human proteins with 82799484
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
(721 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 1447 0.0
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 1295 0.0
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 1295 0.0
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 1057 0.0
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 981 0.0
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 977 0.0
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 955 0.0
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 938 0.0
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 938 0.0
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 900 0.0
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 856 0.0
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 826 0.0
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 736 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 235 1e-61
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 235 1e-61
gi|4505677 phosphodiesterase 1B [Homo sapiens] 233 5e-61
gi|4826894 phosphodiesterase 1C [Homo sapiens] 231 2e-60
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 226 4e-59
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 226 4e-59
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 217 3e-56
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 217 3e-56
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 217 3e-56
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 217 3e-56
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 217 3e-56
gi|9506959 phosphodiesterase 7B [Homo sapiens] 216 5e-56
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 209 9e-54
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 194 3e-49
gi|40254434 phosphodiesterase 3B [Homo sapiens] 181 3e-45
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 177 3e-44
gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens] 177 3e-44
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 1447 bits (3747), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 1 MTAKDSSKELTASEPEVCIKTFKEQMHLELELPRLPGNRPTSPKISPRSSPRNSPCFFRK 60
MTAKDSSKELTASEPEVCIKTFKEQMHLELELPRLPGNRPTSPKISPRSSPRNSPCFFRK
Sbjct: 1 MTAKDSSKELTASEPEVCIKTFKEQMHLELELPRLPGNRPTSPKISPRSSPRNSPCFFRK 60
Query: 61 LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFL 120
LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFL
Sbjct: 61 LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFL 120
Query: 121 YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNK 180
YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNK
Sbjct: 121 YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNK 180
Query: 181 RSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN 240
RSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN
Sbjct: 181 RSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN 240
Query: 241 RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM 300
RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM
Sbjct: 241 RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM 300
Query: 301 HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER 360
HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
Sbjct: 301 HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER 360
Query: 361 DLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE 420
DLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE
Sbjct: 361 DLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE 420
Query: 421 ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF 480
ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF
Sbjct: 421 ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF 480
Query: 481 MNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV 540
MNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV
Sbjct: 481 MNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV 540
Query: 541 LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ 600
LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ
Sbjct: 541 LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ 600
Query: 601 VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLM 660
VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLM
Sbjct: 601 VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLM 660
Query: 661 EKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVD 720
EKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVD
Sbjct: 661 EKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVD 720
Query: 721 T 721
T
Sbjct: 721 T 721
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 1295 bits (3352), Expect = 0.0
Identities = 645/648 (99%), Positives = 646/648 (99%)
Query: 74 TVAHTCFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 133
TV+ CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA
Sbjct: 89 TVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 148
Query: 134 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 193
MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV
Sbjct: 149 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 208
Query: 194 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 253
NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG
Sbjct: 209 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 268
Query: 254 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF 313
NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF
Sbjct: 269 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF 328
Query: 314 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 373
GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF
Sbjct: 329 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 388
Query: 374 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 433
ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV
Sbjct: 389 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 448
Query: 434 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 493
DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK
Sbjct: 449 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 508
Query: 494 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 553
MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP
Sbjct: 509 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 568
Query: 554 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 613
TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE
Sbjct: 569 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 628
Query: 614 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED 673
TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED
Sbjct: 629 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED 688
Query: 674 SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT 721
SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
Sbjct: 689 SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT 736
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 1295 bits (3352), Expect = 0.0
Identities = 645/648 (99%), Positives = 646/648 (99%)
Query: 74 TVAHTCFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 133
TV+ CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA
Sbjct: 89 TVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKA 148
Query: 134 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 193
MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV
Sbjct: 149 MSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRV 208
Query: 194 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 253
NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG
Sbjct: 209 NPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSG 268
Query: 254 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF 313
NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF
Sbjct: 269 NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRF 328
Query: 314 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 373
GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF
Sbjct: 329 GVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTF 388
Query: 374 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 433
ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV
Sbjct: 389 ITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV 448
Query: 434 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 493
DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK
Sbjct: 449 DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRK 508
Query: 494 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 553
MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP
Sbjct: 509 MVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNP 568
Query: 554 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 613
TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE
Sbjct: 569 TKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWE 628
Query: 614 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED 673
TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED
Sbjct: 629 TWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEED 688
Query: 674 SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT 721
SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
Sbjct: 689 SEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT 736
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 1057 bits (2734), Expect = 0.0
Identities = 531/554 (95%), Positives = 534/554 (96%), Gaps = 4/554 (0%)
Query: 172 TNLHGTSNKRSPAASQPPVSRVNP----QEESYQKLAMETLEELDWCLDQLETIQTYRSV 227
T + G S + + QP P EESYQKLAMETLEELDWCLDQLETIQTYRSV
Sbjct: 11 TGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQLETIQTYRSV 70
Query: 228 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 287
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ
Sbjct: 71 SEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ 130
Query: 288 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 347
QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR
Sbjct: 131 QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNR 190
Query: 348 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 407
PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
Sbjct: 191 PLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL 250
Query: 408 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 467
STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV
Sbjct: 251 STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAV 310
Query: 468 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 527
GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG
Sbjct: 311 GFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSG 370
Query: 528 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 587
VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP
Sbjct: 371 VLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP 430
Query: 588 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 647
MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP
Sbjct: 431 MCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSP 490
Query: 648 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 707
PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET
Sbjct: 491 PLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGET 550
Query: 708 DIDIATEDKSPVDT 721
DIDIATEDKSPVDT
Sbjct: 551 DIDIATEDKSPVDT 564
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 981 bits (2535), Expect = 0.0
Identities = 496/629 (78%), Positives = 548/629 (87%), Gaps = 8/629 (1%)
Query: 79 CFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNS 138
CFDV+NG S GRSPLDP S +GL+L A F HSQRRESFLYRSDSDYDLSPK+MSRNS
Sbjct: 16 CFDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNS 74
Query: 139 SLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQE 197
S+ S+ HGDDLIVTPFAQVLASLR+VRNNF LTNL + +KRSP +QP +++ E
Sbjct: 75 SIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITE 134
Query: 198 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 257
E+YQKLA ETLEELDWCLDQLET+QT SVSEMASNKFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 135 EAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 194
Query: 258 EYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT 317
E+ISNTFLDKQ++VEIPSPTQK++EKKK+ M+QISGVKKLMHSSSL N+SI RFGV T
Sbjct: 195 EFISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKT 252
Query: 318 ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYM 377
E ED LAKELED+NKWGL++F +A S NRPLT IM+ IFQERDLLKTF+I DT ITY+
Sbjct: 253 EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYL 312
Query: 378 MTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPG 437
MTLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPG
Sbjct: 313 MTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPG 372
Query: 438 VSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVID 497
VSNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID
Sbjct: 373 VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVID 432
Query: 498 MVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL 557
+VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L
Sbjct: 433 IVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL 492
Query: 558 ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 617
+LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWAD
Sbjct: 493 QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWAD 552
Query: 618 LVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGP 677
LV PDAQDILDTLEDNR WYQS IPQSPSP D+ QG EKFQFELTL+E+
Sbjct: 553 LVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDT 612
Query: 678 EKEG----EGHSYFSSTKTLCVIDPENRD 702
EK+ E + S +KTLC D E+ +
Sbjct: 613 EKDSGSQVEEDTSCSDSKTLCTQDSESTE 641
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 977 bits (2526), Expect = 0.0
Identities = 495/628 (78%), Positives = 547/628 (87%), Gaps = 8/628 (1%)
Query: 80 FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSS 139
FDV+NG S GRSPLDP S +GL+L A F HSQRRESFLYRSDSDYDLSPK+MSRNSS
Sbjct: 153 FDVDNGTSAGRSPLDPMTSPGSGLILQANFV-HSQRRESFLYRSDSDYDLSPKSMSRNSS 211
Query: 140 LPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTS-NKRSPAASQPPVSRVNPQEE 198
+ S+ HGDDLIVTPFAQVLASLR+VRNNF LTNL + +KRSP +QP +++ EE
Sbjct: 212 IASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEE 271
Query: 199 SYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 258
+YQKLA ETLEELDWCLDQLET+QT SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE
Sbjct: 272 AYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSE 331
Query: 259 YISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTE 318
+ISNTFLDKQ++VEIPSPTQK++EKKK+ M+QISGVKKLMHSSSL N+SI RFGV TE
Sbjct: 332 FISNTFLDKQHEVEIPSPTQKEKEKKKRP--MSQISGVKKLMHSSSLTNSSIPRFGVKTE 389
Query: 319 NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMM 378
ED LAKELED+NKWGL++F +A S NRPLT IM+ IFQERDLLKTF+I DT ITY+M
Sbjct: 390 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLM 449
Query: 379 TLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGV 438
TLEDHYH+DVAYHN++HAADV QSTHVLLSTPAL+AVFTDLEILAAIFA+AIHDVDHPGV
Sbjct: 450 TLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGV 509
Query: 439 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDM 498
SNQFLINTNSELALMYND SVLENHHLAVGFKLLQEE+CDIF NLTKKQRQ+LRKMVID+
Sbjct: 510 SNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDI 569
Query: 499 VLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE 558
VLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVL+NMVHCADLSNPTK L+
Sbjct: 570 VLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ 629
Query: 559 LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL 618
LYRQWTDRIMEEFF+QGD+ERERGMEISPMCDKH ASVEKSQVGFIDYIVHPLWETWADL
Sbjct: 630 LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADL 689
Query: 619 VQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPE 678
V PDAQDILDTLEDNR WYQS IPQSPSP D+ QG EKFQFELTL+E+ E
Sbjct: 690 VHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGESDTE 749
Query: 679 KEG----EGHSYFSSTKTLCVIDPENRD 702
K+ E + S +KTLC D E+ +
Sbjct: 750 KDSGSQVEEDTSCSDSKTLCTQDSESTE 777
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 955 bits (2469), Expect = 0.0
Identities = 499/662 (75%), Positives = 554/662 (83%), Gaps = 23/662 (3%)
Query: 33 PRLPGNRPTSPKISPRSSPRNSPCFFRKLLVNKSIRQRRRFTVAHTCFDVENGP--SPGR 90
PR P RP SP SP SP F R+L + +S + R A F+ ENGP SPGR
Sbjct: 36 PRAP-RRPRSPPSSPVFFASPSPTFRRRLRLLRSCQDLGRQAWAGAGFEAENGPTPSPGR 94
Query: 91 SPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLI 150
SPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRNSS+ SE H +DLI
Sbjct: 95 SPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLI 151
Query: 151 VTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEE 210
VTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + EE+ Q+LA ETLEE
Sbjct: 152 VTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEE 211
Query: 211 LDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQND 270
LDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+
Sbjct: 212 LDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNE 271
Query: 271 VEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHSSSLNNTSISRFGV 315
VEIPSPT K+REK++ Q M+QI+G+KKLMHS+SLNN++I RFGV
Sbjct: 272 VEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGV 331
Query: 316 NTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFIT 375
T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDLLK FRI DT +T
Sbjct: 332 KTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVT 391
Query: 376 YMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDH 435
YM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDH
Sbjct: 392 YMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDH 451
Query: 436 PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMV 495
PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMV
Sbjct: 452 PGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMV 511
Query: 496 IDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTK 555
IDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK
Sbjct: 512 IDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTK 571
Query: 556 SLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 615
LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW
Sbjct: 572 PLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETW 631
Query: 616 ADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEED 673
ADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L +KFQFELTL+EE+
Sbjct: 632 ADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEE 691
Query: 674 SE 675
E
Sbjct: 692 EE 693
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 938 bits (2424), Expect = 0.0
Identities = 482/615 (78%), Positives = 533/615 (86%), Gaps = 22/615 (3%)
Query: 80 FDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRN 137
F+ ENGP SPGRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRN
Sbjct: 47 FEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRN 103
Query: 138 SSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQE 197
SS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + E
Sbjct: 104 SSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSE 163
Query: 198 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 257
E+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 164 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 223
Query: 258 EYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHS 302
EYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI+G+KKLMHS
Sbjct: 224 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 283
Query: 303 SSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDL 362
+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDL
Sbjct: 284 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 343
Query: 363 LKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEIL 422
LK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEIL
Sbjct: 344 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 403
Query: 423 AAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMN 482
AA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF N
Sbjct: 404 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 463
Query: 483 LTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR 542
L+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLR
Sbjct: 464 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 523
Query: 543 NMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVG 602
NMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVG
Sbjct: 524 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 583
Query: 603 FIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLM 660
FIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L
Sbjct: 584 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 643
Query: 661 EKFQFELTLDEEDSE 675
+KFQFELTL+EE+ E
Sbjct: 644 DKFQFELTLEEEEEE 658
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 938 bits (2424), Expect = 0.0
Identities = 482/615 (78%), Positives = 533/615 (86%), Gaps = 22/615 (3%)
Query: 80 FDVENGP--SPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRN 137
F+ ENGP SPGRSPLD QAS GLVLHA SQRRESFLYRSDSDYD+SPK MSRN
Sbjct: 108 FEAENGPTPSPGRSPLDSQASP--GLVLHAG-AATSQRRESFLYRSDSDYDMSPKTMSRN 164
Query: 138 SSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQE 197
SS+ SE H +DLIVTPFAQVLASLRSVR+NF++LTN+ SNKRSP PV + E
Sbjct: 165 SSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSE 224
Query: 198 ESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVS 257
E+ Q+LA ETLEELDWCL+QLET+QTYRSVSEMAS+KFKRMLNRELTHLSEMSRSGNQVS
Sbjct: 225 ETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVS 284
Query: 258 EYISNTFLDKQNDVEIPSPTQKDREKKKKQ---------------QLMTQISGVKKLMHS 302
EYIS TFLDKQN+VEIPSPT K+REK++ Q M+QI+G+KKLMHS
Sbjct: 285 EYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHS 344
Query: 303 SSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDL 362
+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNIF V+ Y+ R LTCIMY IFQERDL
Sbjct: 345 NSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDL 404
Query: 363 LKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEIL 422
LK FRI DT +TYM+TLEDHYH+DVAYHNSLHAADV QSTHVLL+TPALDAVFTDLEIL
Sbjct: 405 LKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEIL 464
Query: 423 AAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMN 482
AA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQE++CDIF N
Sbjct: 465 AALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQN 524
Query: 483 LTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR 542
L+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTMVETKKVTSSGVLLLDNY+DRIQVLR
Sbjct: 525 LSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR 584
Query: 543 NMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVG 602
NMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+ERERGMEISPMCDKHTASVEKSQVG
Sbjct: 585 NMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVG 644
Query: 603 FIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNR--DCQGLM 660
FIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY S I QSPSPP +E++R L
Sbjct: 645 FIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLP 704
Query: 661 EKFQFELTLDEEDSE 675
+KFQFELTL+EE+ E
Sbjct: 705 DKFQFELTLEEEEEE 719
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 900 bits (2325), Expect = 0.0
Identities = 464/666 (69%), Positives = 541/666 (81%), Gaps = 12/666 (1%)
Query: 36 PGNRPTSPKISPRSSPRNSPCFFRKLLVNKSIRQRRRFTVAHT-CFDVENGPSPGRSPLD 94
P P SPR SPR SP FRKLLVN+SIR +RRFTVAH CFD+ENG S GR LD
Sbjct: 5 PAPAPVPGPGSPRGSPRGSPGLFRKLLVNQSIRLQRRFTVAHPLCFDLENGLSCGRRALD 64
Query: 95 PQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPF 154
PQ+S G ++ A P HSQRRESFLYRSDSDY+LSPKAMSRNSS+ S+ HG+D+IVTPF
Sbjct: 65 PQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPF 123
Query: 155 AQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDW 213
AQVLASLR+VR+N L + K+ P + +++ P E++ QKLA+ETL+ELDW
Sbjct: 124 AQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDW 183
Query: 214 CLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEI 273
CLDQLET+QT SV EMASNKFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q +VE+
Sbjct: 184 CLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVEL 243
Query: 274 PSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKW 333
P T ++ Q M++ISG+ L HS+SL++ ++ RFGV T+ E+ LAKELED NKW
Sbjct: 244 PKVTAEEAP-----QPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKW 298
Query: 334 GLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNS 393
GL++F VA S NRPLT I+++IFQERDLLKTF+I +DT TY++ LE HYH++VAYHNS
Sbjct: 299 GLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNS 358
Query: 394 LHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALM 453
LHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALM
Sbjct: 359 LHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALM 418
Query: 454 YNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLAD 513
YND SVLENHHLAVGFKLLQ E+CDIF NL+ KQR +LR+MVIDMVLATDMSKHM+LLAD
Sbjct: 419 YNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLAD 478
Query: 514 LKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQ 573
LKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHCADLSNPTK L LYRQWTDRIM EFFQ
Sbjct: 479 LKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQ 538
Query: 574 QGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDN 633
QGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI HPLWETWADLV PDAQD+LDTLEDN
Sbjct: 539 QGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDN 598
Query: 634 RNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTL 693
R WYQS IP+SPS D N + G ++FQFELTL+E + E E+E EG + + L
Sbjct: 599 REWYQSKIPRSPS---DLTNPERDG-PDRFQFELTLEEAEEEDEEEEEEGEETALAKEAL 654
Query: 694 CVIDPE 699
+ D E
Sbjct: 655 ELPDTE 660
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 856 bits (2211), Expect = 0.0
Identities = 452/692 (65%), Positives = 539/692 (77%), Gaps = 18/692 (2%)
Query: 16 EVCIKTFKEQ-MHLELELPRLPGNRPTSP-KISPR--SSP-RNSPCFFRKLLVNKSIRQR 70
E C + + + H P+ +P P +I R S P +++ C R L +R+
Sbjct: 11 EACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKS 70
Query: 71 RRFTVAHTC--FDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYD 128
R +C FD+ENG S GR LDPQ+S G ++ A P HSQRRESFLYRSDSDY+
Sbjct: 71 RLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVP-HSQRRESFLYRSDSDYE 129
Query: 129 LSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGT-SNKRSPAASQ 187
LSPKAMSRNSS+ S+ HG+D+IVTPFAQVLASLR+VR+N L + K+ P +
Sbjct: 130 LSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNP 189
Query: 188 PPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLS 247
+++ P E++ QKLA+ETL+ELDWCLDQLET+QT SV EMASNKFKR+LNRELTHLS
Sbjct: 190 SSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLS 249
Query: 248 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 307
E SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M++ISG+ L HS+SL++
Sbjct: 250 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPMSRISGLHGLCHSASLSS 304
Query: 308 TSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFR 367
++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT I+++IFQERDLLKTF+
Sbjct: 305 ATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQ 364
Query: 368 ISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFA 427
I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TPAL+AVFTDLEILAA+FA
Sbjct: 365 IPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFA 424
Query: 428 AAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQ 487
+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFKLLQ E+CDIF NL+ KQ
Sbjct: 425 SAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQ 484
Query: 488 RQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHC 547
R +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLLLDNY+DRIQVL+N+VHC
Sbjct: 485 RLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHC 544
Query: 548 ADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYI 607
ADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCDKHTASVEKSQVGFIDYI
Sbjct: 545 ADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYI 604
Query: 608 VHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFEL 667
HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D N + G ++FQFEL
Sbjct: 605 AHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---DLTNPERDG-PDRFQFEL 660
Query: 668 TLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 699
TL+E + E E+E EG + + L + D E
Sbjct: 661 TLEEAEEEDEEEEEEGEETALAKEALELPDTE 692
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 826 bits (2134), Expect = 0.0
Identities = 420/589 (71%), Positives = 491/589 (83%), Gaps = 10/589 (1%)
Query: 112 HSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTIL 171
HSQRRESFLYRSDSDY+LSPKAMSRNSS+ S+ HG+D+IVTPFAQVLASLR+VR+N L
Sbjct: 7 HSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAAL 66
Query: 172 TNLHGT-SNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEM 230
+ K+ P + +++ P E++ QKLA+ETL+ELDWCLDQLET+QT SV EM
Sbjct: 67 ARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEM 126
Query: 231 ASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLM 290
ASNKFKR+LNRELTHLSE SRSGNQVSEYIS TFLD+Q +VE+P T ++ Q M
Sbjct: 127 ASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAP-----QPM 181
Query: 291 TQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLT 350
++ISG+ L HS+SL++ ++ RFGV T+ E+ LAKELED NKWGL++F VA S NRPLT
Sbjct: 182 SRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLT 241
Query: 351 CIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTP 410
I+++IFQERDLLKTF+I +DT TY++ LE HYH++VAYHNSLHAADVAQSTHVLL+TP
Sbjct: 242 AIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATP 301
Query: 411 ALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFK 470
AL+AVFTDLEILAA+FA+AIHDVDHPGVSNQFLINTNSELALMYND SVLENHHLAVGFK
Sbjct: 302 ALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFK 361
Query: 471 LLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLL 530
LLQ E+CDIF NL+ KQR +LR+MVIDMVLATDMSKHM+LLADLKTMVETKKVTS GVLL
Sbjct: 362 LLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLL 421
Query: 531 LDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCD 590
LDNY+DRIQVL+N+VHCADLSNPTK L LYRQWTDRIM EFFQQGD+ERE G++ISPMCD
Sbjct: 422 LDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCD 481
Query: 591 KHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLD 650
KHTASVEKSQVGFIDYI HPLWETWADLV PDAQD+LDTLEDNR WYQS IP+SPS D
Sbjct: 482 KHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPS---D 538
Query: 651 EQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPE 699
N + G ++FQFELTL+E + E E+E EG + + L + D E
Sbjct: 539 LTNPERDG-PDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTE 586
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 736 bits (1900), Expect = 0.0
Identities = 370/460 (80%), Positives = 409/460 (88%), Gaps = 17/460 (3%)
Query: 233 NKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQ----- 287
++FKRMLNRELTHLSEMSRSGNQVSEYIS TFLDKQN+VEIPSPT K+REK++
Sbjct: 21 DQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPS 80
Query: 288 ----------QLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI 337
Q M+QI+G+KKLMHS+SLNN++I RFGV T+ E+ LA+ELE+LNKWGLNI
Sbjct: 81 QPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNI 140
Query: 338 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 397
F V+ Y+ R LTCIMY IFQERDLLK FRI DT +TYM+TLEDHYH+DVAYHNSLHAA
Sbjct: 141 FCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAA 200
Query: 398 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 457
DV QSTHVLL+TPALDAVFTDLEILAA+FAAAIHDVDHPGVSNQFLINTNSELALMYNDE
Sbjct: 201 DVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 260
Query: 458 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 517
SVLENHHLAVGFKLLQE++CDIF NL+K+QRQ+LRKMVIDMVLATDMSKHM+LLADLKTM
Sbjct: 261 SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTM 320
Query: 518 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 577
VETKKVTSSGVLLLDNY+DRIQVLRNMVHCADLSNPTK LELYRQWTDRIM EFFQQGD+
Sbjct: 321 VETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDR 380
Query: 578 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 637
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLV PDAQ+ILDTLEDNR+WY
Sbjct: 381 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
Query: 638 QSMIPQSPSPPLDEQNR--DCQGLMEKFQFELTLDEEDSE 675
S I QSPSPP +E++R L +KFQFELTL+EE+ E
Sbjct: 441 YSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEE 480
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 235 bits (599), Expect = 1e-61
Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)
Query: 327 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 386
L+D++KW ++F + S L ++Y +F DL+ F+I IT+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 387 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 445
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 446 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 505
T S++A++YND SVLENHH++ ++L+QEE +I +NL+K + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 506 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 565
H + +++ ++ + G+ DR + + ++H AD+S+P KS +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 566 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 617
+MEEFF QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 235 bits (599), Expect = 1e-61
Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)
Query: 327 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 386
L+D++KW ++F + S L ++Y +F DL+ F+I IT+ LE Y
Sbjct: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
Query: 387 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 445
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
Query: 446 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 505
T S++A++YND SVLENHH++ ++L+QEE +I +NL+K + LR +VI+MVL+TDMS
Sbjct: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
Query: 506 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 565
H + +++ ++ + G+ DR + + ++H AD+S+P KS +L+ +WT
Sbjct: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
Query: 566 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 617
+MEEFF QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 233 bits (594), Expect = 5e-61
Identities = 125/330 (37%), Positives = 198/330 (60%), Gaps = 15/330 (4%)
Query: 327 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 386
L++L+ W ++F++ + + L I++ + +L+ F+I + ++++ LE Y
Sbjct: 158 LKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGK 217
Query: 387 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 445
YHN +HAADV Q+ H L + +++E+LA IFAAAIHD +H G +N F I
Sbjct: 218 YKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQ 277
Query: 446 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 505
T SE A++YND SVLENHH++ F+L+Q++ +IF+NLTK + LR +VI+MVLATDMS
Sbjct: 278 TKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMS 337
Query: 506 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 565
H + +KT ++ + D+ + L ++H AD+S+PTK ++ +WT
Sbjct: 338 CHFQQVKTMKTALQQLE-----------RIDKPKALSLLLHAADISHPTKQWLVHSRWTK 386
Query: 566 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQD 625
+MEEFF+QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D+ + Q
Sbjct: 387 ALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQP 446
Query: 626 ILDTLEDNRNWYQSMIPQSPSPPLDEQNRD 655
+ D ED+++ Q Q P LD + D
Sbjct: 447 LAD--EDSKSKNQPSF-QWRQPSLDVEVGD 473
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 231 bits (588), Expect = 2e-60
Identities = 133/397 (33%), Positives = 222/397 (55%), Gaps = 26/397 (6%)
Query: 236 KRMLNRELTHLSEMSRSG--NQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQI 293
+R+L+ E LS++ ++V +++++TF +Q + + +K R K + I
Sbjct: 81 RRLLDTE-DELSDIQSDAVPSEVRDWLASTFT-RQMGMMLRRSDEKPRFKSIVHAVQAGI 138
Query: 294 SGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIM 353
+ +S++ V + + L+D++KW ++F++ S + L I
Sbjct: 139 FVERMYRRTSNM---------VGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIF 189
Query: 354 YAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV-AYHNSLHAADVAQSTHVLLSTPAL 412
Y + DL+ F+I ++++ LE Y YHN +HAADV Q+ H LL +
Sbjct: 190 YELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGV 249
Query: 413 DAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL 472
T+LEI A IF+AAIHD +H G +N F I T S+ A++YND SVLENHHL+ ++LL
Sbjct: 250 ANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLL 309
Query: 473 Q-EEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLL 531
Q +E +I +NL+K + R +VI+MV+ATDMS H + +KT ++ +
Sbjct: 310 QDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-------- 361
Query: 532 DNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDK 591
++ + L M+H AD+S+P K+ +L+ +WT ++EEFF+QGD+E E G+ SP+CD+
Sbjct: 362 ---IEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDR 418
Query: 592 HTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILD 628
+ V +SQVGFID+IV P + D+ + ++D
Sbjct: 419 KSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLID 455
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 226 bits (577), Expect = 4e-59
Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)
Query: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
+A+ +E+ W +IF + +HNRPL + +F + + S T +++ +E
Sbjct: 442 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 501
Query: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
+YHS YHNS H+ADV +T LS + ++ +AA+ AA IHDVDHPG +N F
Sbjct: 502 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 561
Query: 443 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
L N SELA++YND +VLE+HH A+ F+L ++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 562 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 621
Query: 502 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 550
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 622 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 681
Query: 551 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 609
SNP + L+ +W RI EE+F Q D+E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 682 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 741
Query: 610 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 640
+++ W V D D++ L++N +++ +
Sbjct: 742 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 770
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 226 bits (577), Expect = 4e-59
Identities = 119/331 (35%), Positives = 193/331 (58%), Gaps = 15/331 (4%)
Query: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
+A+ +E+ W +IF + +HNRPL + +F + + S T +++ +E
Sbjct: 488 IARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEA 547
Query: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
+YHS YHNS H+ADV +T LS + ++ +AA+ AA IHDVDHPG +N F
Sbjct: 548 NYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSF 607
Query: 443 LINTNSELALMYNDESVLENHHLAVGFKLLQ-EEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
L N SELA++YND +VLE+HH A+ F+L ++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 608 LCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLA 667
Query: 502 TDMSKHM-----------SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADL 550
T+M+KH LA L+ ET K +L +R + R ++ CAD+
Sbjct: 668 TEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADV 727
Query: 551 SNPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVH 609
SNP + L+ +W RI EE+F Q D+E+++G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 728 SNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 610 PLWETWADLVQPDAQDILDTLEDNRNWYQSM 640
+++ W V D D++ L++N +++ +
Sbjct: 788 DMFDAWDAFV--DLPDLMQHLDNNFKYWKGL 816
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 500 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 559
Query: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 560 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 619
Query: 443 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 620 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 679
Query: 502 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 551
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 680 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 736
Query: 552 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 610
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 737 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 796
Query: 611 LWETWADLVQPDAQDILDTLEDN-RNW 636
+++ W A ++ L DN ++W
Sbjct: 797 MFDAWDAFAHLPA--LMQHLADNYKHW 821
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 527 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 586
Query: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 587 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 646
Query: 443 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 647 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 706
Query: 502 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 551
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 707 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 763
Query: 552 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 610
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 764 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 823
Query: 611 LWETWADLVQPDAQDILDTLEDN-RNW 636
+++ W A ++ L DN ++W
Sbjct: 824 MFDAWDAFAHLPA--LMQHLADNYKHW 848
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 492 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 551
Query: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 552 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 611
Query: 443 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 612 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 671
Query: 502 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 551
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 672 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 728
Query: 552 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 610
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 729 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 788
Query: 611 LWETWADLVQPDAQDILDTLEDN-RNW 636
+++ W A ++ L DN ++W
Sbjct: 789 MFDAWDAFAHLPA--LMQHLADNYKHW 813
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 450 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 509
Query: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 510 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 569
Query: 443 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 570 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 629
Query: 502 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 551
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 630 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 686
Query: 552 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 610
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 687 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 746
Query: 611 LWETWADLVQPDAQDILDTLEDN-RNW 636
+++ W A ++ L DN ++W
Sbjct: 747 MFDAWDAFAHLPA--LMQHLADNYKHW 771
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 217 bits (552), Expect = 3e-56
Identities = 117/327 (35%), Positives = 188/327 (57%), Gaps = 18/327 (5%)
Query: 323 LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLED 382
+++ L++ W NIF + +H RPL + +F + + S T + +E
Sbjct: 547 ISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEA 606
Query: 383 HYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQF 442
+YHS AYHNS HAADV +T L + L+ +AA+ AA +HDVDHPG +N F
Sbjct: 607 NYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSF 666
Query: 443 LINTNSELALMYNDESVLENHHLAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLA 501
L N SELA++YND +VLE+HH A+ F+L +++ C+IF N+ + +TLR+ +IDMVLA
Sbjct: 667 LCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLA 726
Query: 502 TDMSKHM--------SLLADLKTMVETK--KVTSSGVLLLDNYTDRIQVLRNMVHCADLS 551
T+M+KH S+ + +E + +G +N +I + R M+ CAD++
Sbjct: 727 TEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPEN---QILIKRMMIKCADVA 783
Query: 552 NPTKSLELYRQWTDRIMEEFFQQGDKERERGME-ISPMCDKHTASVEKSQVGFIDYIVHP 610
NP + L+L +W RI EE+F Q D+E+ +G+ + P+ D++T S+ KSQ+ FIDY +
Sbjct: 784 NPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITD 843
Query: 611 LWETWADLVQPDAQDILDTLEDN-RNW 636
+++ W A ++ L DN ++W
Sbjct: 844 MFDAWDAFAHLPA--LMQHLADNYKHW 868
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 216 bits (551), Expect = 5e-56
Identities = 120/366 (32%), Positives = 208/366 (56%), Gaps = 17/366 (4%)
Query: 283 KKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNK---WGLNIFN 339
KKK ++L++ ++ H+S L I + ++ +ED+L + L+K W +IF
Sbjct: 66 KKKVKRLLS----FQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFL 121
Query: 340 VAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADV 399
++ L ++ +F L+ F++ T +++ +++ YHS YHN++HAADV
Sbjct: 122 FDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADV 181
Query: 400 AQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV 459
Q+ H L P L + T L+I+ + AAA HDVDHPGV+ FLI TN LA +Y + SV
Sbjct: 182 TQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSV 241
Query: 460 LENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVE 519
LENHH +L+E + +L K+ Q + + + ++LATD+++ L LK +
Sbjct: 242 LENHHWRSTIGMLRESR--LLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLH 299
Query: 520 TKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKER 579
K L L++ DR +L+ + CAD+ NP + E+ +QW++R+ EEF++QG+ E+
Sbjct: 300 NKD------LRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQ 353
Query: 580 ERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPD--AQDILDTLEDNRNWY 637
+ +EISP+C++ S+ Q+GF+ YIV PL+ WA ++++L L N+ +
Sbjct: 354 KFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQW 413
Query: 638 QSMIPQ 643
+S++P+
Sbjct: 414 KSLLPR 419
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 209 bits (531), Expect = 9e-54
Identities = 120/372 (32%), Positives = 199/372 (53%), Gaps = 23/372 (6%)
Query: 248 EMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNN 307
E R G+ YI Q+++E+ + R +S + L S
Sbjct: 52 ESERRGSH--PYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRSSRFFRG 100
Query: 308 TSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLK 364
T++S +N ++D+ + LE + W +IF ++ L + + +F L++
Sbjct: 101 TAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIE 159
Query: 365 TFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAA 424
F + +++ +++ YHS YHN++HAADV Q+ H L P L T +IL +
Sbjct: 160 YFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLS 219
Query: 425 IFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLT 484
+ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E +F +L
Sbjct: 220 LIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLP 277
Query: 485 KKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNM 544
+ RQ + + ++LATD+S+ L+ ++ ++ G L L++ R VL+
Sbjct: 278 LESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRHLVLQMA 331
Query: 545 VHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFI 604
+ CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+ Q+GF+
Sbjct: 332 LKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFM 391
Query: 605 DYIVHPLWETWA 616
Y+V PL+ WA
Sbjct: 392 TYLVEPLFTEWA 403
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 194 bits (492), Expect = 3e-49
Identities = 125/429 (29%), Positives = 221/429 (51%), Gaps = 29/429 (6%)
Query: 189 PVSRVNPQEESYQK--LAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHL 246
P+ R PQ ++ ++ + L C + + Q ++S +S++ + R L +
Sbjct: 11 PLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYI-RMLGDV 69
Query: 247 SEMSRSGNQVSEYISNTFLD-----KQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMH 301
SR+G + S+ ++D Q+++E+ + R +S + L
Sbjct: 70 RVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRL---------LSFQRYLRS 120
Query: 302 SSSLNNTSISRFGVNTENEDHLAKE---LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ 358
S T++S +N ++D+ + LE + W +IF ++ L + + +F
Sbjct: 121 SRFFRGTAVSN-SLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFS 179
Query: 359 ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD 418
L++ F + +++ +++ YHS YHN++HAADV Q+ H L P L T
Sbjct: 180 LHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTP 239
Query: 419 LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCD 478
+IL ++ AAA HD+DHPGV+ FLI TN LA +Y + SVLENHH LL+E
Sbjct: 240 WDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRES--G 297
Query: 479 IFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 538
+F +L + RQ + + ++LATD+S+ L+ ++ ++ G L L++ R
Sbjct: 298 LFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLD------RGDLCLEDTRHRH 351
Query: 539 QVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEK 598
VL+ + CAD+ NP ++ EL +QW++++ EEFF QGD E++ + +SP+CD+HT S+
Sbjct: 352 LVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIAN 411
Query: 599 SQVGFIDYI 607
Q+G Y+
Sbjct: 412 IQIGNYTYL 420
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 181 bits (458), Expect = 3e-45
Identities = 120/392 (30%), Positives = 187/392 (47%), Gaps = 60/392 (15%)
Query: 277 TQKDREKKKKQQLMTQISGVKKLMHSSSLNNTS-----ISRFGVNTENEDHLAKELEDLN 331
TQ++ E +KK G K L + + +S + E D L +E ++
Sbjct: 619 TQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSL---IEKMS 675
Query: 332 KWGLNIFNVA---GYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDV 388
W IF + G R L+ +MY +FQ+ LL+ F+I + F+ Y LE+ Y D+
Sbjct: 676 NWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYR-DI 734
Query: 389 AYHNSLHAADVAQSTHVLLSTPA------------------------------------- 411
YHN +HA DV + L + P
Sbjct: 735 PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSN 794
Query: 412 -------LDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH 464
L + LE++A AAA+HD DHPG +N FL+ TN+ A++YND SVLENHH
Sbjct: 795 PDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHH 854
Query: 465 LAVGFKL-LQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKV 523
A + L L + ++L + + R +VI+ +LATD+ KH LA+ + V
Sbjct: 855 AASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNA--KANDV 912
Query: 524 TSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGM 583
S+G+ N DR+ V + + AD++ P K +L+ +WT+ I+ EF++QGD+E G+
Sbjct: 913 NSNGIEW-SNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGL 971
Query: 584 EISPMCDKHTASVEKSQVGFIDYIVHPLWETW 615
ISP D+ + + K Q FI +IV PL ++
Sbjct: 972 PISPFMDRSSPQLAKLQESFITHIVGPLCNSY 1003
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (449), Expect = 3e-44
Identities = 101/341 (29%), Positives = 187/341 (54%), Gaps = 13/341 (3%)
Query: 338 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 397
F+V + N L+C+ + ++ + L++ F I+ T ++ + D+Y ++ +HN H
Sbjct: 54 FDVWLWEPNEMLSCLEH-MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCF 111
Query: 398 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 457
VAQ + ++ +L F+ +IL + AA HD+DHPG +N + IN +ELA+ YND
Sbjct: 112 CVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171
Query: 458 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 517
S LENHH AV F++L E C+IF N+ + +R+ +I ++LATDM++H ++ K
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231
Query: 518 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 577
+E ++ + L + ++ C D+SN + +E+ W D ++EE+F Q D+
Sbjct: 232 MENFDYSNEEHMTL--------LKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDR 283
Query: 578 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 637
E+ G+ ++P D+ + +Q+GFI +++ P++ET L + +L L ++R+ Y
Sbjct: 284 EKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRY 343
Query: 638 QSM--IPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEG 676
+ + I + + + G EK + E + D ++SEG
Sbjct: 344 EELKRIDDAMKELQKKTDSLTSGATEKSR-ERSRDVKNSEG 383
>gi|48762754 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 177 bits (449), Expect = 3e-44
Identities = 101/341 (29%), Positives = 187/341 (54%), Gaps = 13/341 (3%)
Query: 338 FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA 397
F+V + N L+C+ + ++ + L++ F I+ T ++ + D+Y ++ +HN H
Sbjct: 54 FDVWLWEPNEMLSCLEH-MYHDLGLVRDFSINPVTLRRWLFCVHDNYRNN-PFHNFRHCF 111
Query: 398 DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE 457
VAQ + ++ +L F+ +IL + AA HD+DHPG +N + IN +ELA+ YND
Sbjct: 112 CVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDI 171
Query: 458 SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM 517
S LENHH AV F++L E C+IF N+ + +R+ +I ++LATDM++H ++ K
Sbjct: 172 SPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEK 231
Query: 518 VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK 577
+E ++ + L + ++ C D+SN + +E+ W D ++EE+F Q D+
Sbjct: 232 MENFDYSNEEHMTL--------LKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDR 283
Query: 578 ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 637
E+ G+ ++P D+ + +Q+GFI +++ P++ET L + +L L ++R+ Y
Sbjct: 284 EKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRY 343
Query: 638 QSM--IPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEG 676
+ + I + + + G EK + E + D ++SEG
Sbjct: 344 EELKRIDDAMKELQKKTDSLTSGATEKSR-ERSRDVKNSEG 383
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,560,631
Number of Sequences: 37866
Number of extensions: 1269443
Number of successful extensions: 5189
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 4940
Number of HSP's gapped (non-prelim): 157
length of query: 721
length of database: 18,247,518
effective HSP length: 110
effective length of query: 611
effective length of database: 14,082,258
effective search space: 8604259638
effective search space used: 8604259638
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.