Search of human proteins with 80861396

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|80861396 centrobin, centrosomal BRCA2 interacting protein
isoform beta [Homo sapiens]
         (925 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|80861396 centrobin, centrosomal BRCA2 interacting protein iso...  1827   0.0  
gi|191252785 centrobin, centrosomal BRCA2 interacting protein is...  1763   0.0  
gi|148746195 trichohyalin [Homo sapiens]                              107   7e-23
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       104   4e-22
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       104   4e-22
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        104   4e-22
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        104   4e-22
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        104   4e-22
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        104   4e-22
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        104   4e-22
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        104   4e-22
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           89   1e-17
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           89   1e-17
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           89   1e-17
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]          88   3e-17
gi|16262452 cingulin [Homo sapiens]                                    87   5e-17
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    87   7e-17
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                87   7e-17
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]             86   2e-16
gi|21735548 centrosomal protein 2 [Homo sapiens]                       86   2e-16
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    85   3e-16
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         85   4e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    84   8e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    84   8e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    84   8e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    84   8e-16
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    83   1e-15
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    82   2e-15
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    82   2e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     82   2e-15

>gi|80861396 centrobin, centrosomal BRCA2 interacting protein
           isoform beta [Homo sapiens]
          Length = 925

 Score = 1827 bits (4732), Expect = 0.0
 Identities = 925/925 (100%), Positives = 925/925 (100%)

Query: 1   MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60
           MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS
Sbjct: 1   MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60

Query: 61  TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120
           TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD
Sbjct: 61  TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120

Query: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180
           PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP
Sbjct: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180

Query: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240
           PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA
Sbjct: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240

Query: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300
           RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR
Sbjct: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300

Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
           LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ
Sbjct: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360

Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420
           TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD
Sbjct: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420

Query: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
           TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH
Sbjct: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480

Query: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540
           HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ
Sbjct: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540

Query: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600
           QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW
Sbjct: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600

Query: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660
           TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL
Sbjct: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660

Query: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720
           TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV
Sbjct: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720

Query: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780
           PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH
Sbjct: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780

Query: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGYK 840
           SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGYK
Sbjct: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGYK 840

Query: 841 PGRKEEGFSGWKLDYGEWSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT 900
           PGRKEEGFSGWKLDYGEWSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT
Sbjct: 841 PGRKEEGFSGWKLDYGEWSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT 900

Query: 901 EKPPARKKSGHPAPSSMRSRGGVWR 925
           EKPPARKKSGHPAPSSMRSRGGVWR
Sbjct: 901 EKPPARKKSGHPAPSSMRSRGGVWR 925


>gi|191252785 centrobin, centrosomal BRCA2 interacting protein
           isoform alpha [Homo sapiens]
          Length = 903

 Score = 1763 bits (4567), Expect = 0.0
 Identities = 903/925 (97%), Positives = 903/925 (97%), Gaps = 22/925 (2%)

Query: 1   MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60
           MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS
Sbjct: 1   MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60

Query: 61  TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120
           TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD
Sbjct: 61  TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120

Query: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180
           PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP
Sbjct: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180

Query: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240
           PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA
Sbjct: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240

Query: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300
           RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR
Sbjct: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300

Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
           LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ
Sbjct: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360

Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420
           TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD
Sbjct: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420

Query: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
           TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH
Sbjct: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480

Query: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540
           HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ
Sbjct: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540

Query: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600
           QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW
Sbjct: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600

Query: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660
           TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL
Sbjct: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660

Query: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720
           TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV
Sbjct: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720

Query: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780
           PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH
Sbjct: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780

Query: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGYK 840
           SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEH    
Sbjct: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEH---- 836

Query: 841 PGRKEEGFSGWKLDYGEWSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT 900
                             SGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT
Sbjct: 837 ------------------SGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT 878

Query: 901 EKPPARKKSGHPAPSSMRSRGGVWR 925
           EKPPARKKSGHPAPSSMRSRGGVWR
Sbjct: 879 EKPPARKKSGHPAPSSMRSRGGVWR 903


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  107 bits (266), Expect = 7e-23
 Identities = 99/394 (25%), Positives = 182/394 (46%), Gaps = 25/394 (6%)

Query: 181 PDFQGLR--DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKT 238
           PD + LR  + L+     R+  ++  +  Q RV + +++        RK++T++ + ++ 
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW-----RKRETVLRKEEEK 259

Query: 239 LARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQES 298
           L        R   E  E LR L+ +    E    +QQ+   R EQ L    E   REQ+ 
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319

Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358
            R +Q+ER   +EER+   LR E E++R   L+ E++        E RE +  R   EE 
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQE-------EERREQQLRREQEEER 372

Query: 359 RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGE 418
           R+   ++E QL+   Q  +E+   + ++ + + Q   +     + QL   Q   R  E E
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432

Query: 419 LDTARRERDALQLEMSLVQARYESQR--IQLESELAVQLEQRVTERLAQAQESSLRQA-A 475
               + E++  +  +   Q   E +R  ++ E E     ++R  ++L + QE   R+   
Sbjct: 433 RHEQKHEQERREQRLKREQ---EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489

Query: 476 SLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER-QQQVAEDYELRLAREQARVCE 534
            L E  R++ Q+   Q  +    +  + +++  E EER QQ++  + +LR  +E+ R   
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549

Query: 535 LQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568
           L    ++ EE+R+E   R Q + +   +  +QLL
Sbjct: 550 L----KREEEKRLEQERREQRLKREQEERRDQLL 579



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 116/464 (25%), Positives = 192/464 (41%), Gaps = 53/464 (11%)

Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
           +  EE  +    T        LQ+  P    +  EE             L   + Q LR 
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE----------EEQLRKLERQELRR 288

Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
               E  +++   R  Q  + +  E ++Q         +++   E+ ++ L R       
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR------E 342

Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET 308
            E  R + LR  QEE +  +  R +Q+E   R EQ L    + L REQ+  R QQ  RE 
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEE--RREQQLRREQQ-LRREQQLRREQQLRREQ 399

Query: 309 LEEERQALT----LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQ 364
                Q L     LR E + +R   L+ E++  R  Q  E    E      +EER+ W +
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459

Query: 365 QEHQLKEHYQAL--------QEESQAQ----LEREKEKSQREAQAAWETQHQLALVQSEV 412
           +E + + H Q          QEE + +    LE E+ + Q+E +     + Q    +  +
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519

Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR 472
           +R E E     R +  L+ E  L + + E +   L+ E   +LEQ   E+  + ++   R
Sbjct: 520 KRQEEE----ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575

Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAR----- 527
                RE  R+Q Q L  + ++ L  +L + +VE  E+EER++Q  +  E    R     
Sbjct: 576 DQLLKREEERRQ-QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634

Query: 528 -----EQARVCELQSGNQQLEEQRV---ELVERLQAMLQAHWDE 563
                E+ R  +L+   Q+  EQR+   E  ERL+  L+   +E
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 102/381 (26%), Positives = 168/381 (44%), Gaps = 36/381 (9%)

Query: 184  QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243
            Q  R  L+ E  RR+H      +L  +   LQ+QL       RK+  ++++ ++ L R  
Sbjct: 872  QKWRWQLEEERKRRRH------TLYAKPA-LQEQL-------RKEQQLLQEEEEELQRE- 916

Query: 244  EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ 303
                R +  R E  R  +EE Q  +     ++E + R E+      E   + ++  +LQQ
Sbjct: 917  ---EREKRRRQEQERQYREEEQLQQ-----EEEQLLREEREKRRRQERERQYRKDKKLQQ 968

Query: 304  RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            +E + L EE +    R   E+++    +EE        L E RE    R   E ERQ   
Sbjct: 969  KEEQLLGEEPEK---RRRQEREKKYREEEELQQEEEQLLREEREK---RRRQEWERQYRK 1022

Query: 364  QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423
            + E Q +E  Q L+EE + +  +E+E+  RE +   + + QL   + E RR +      R
Sbjct: 1023 KDELQQEEE-QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081

Query: 424  RERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK 483
            +E +  Q E  L++   E +R Q       + + R  E L Q +E  LR+    R     
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQER-----ERQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 484  QLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLE 543
            + Q    +  Q+   QL + + E   R+E ++Q  E+ EL+   EQ    E +   Q+ E
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196

Query: 544  EQ-RVELVERLQAMLQAHWDE 563
             Q R E   + Q   Q + DE
Sbjct: 1197 RQYREEEELQRQKRKQRYRDE 1217



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 115/433 (26%), Positives = 194/433 (44%), Gaps = 59/433 (13%)

Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADR----------KKDTMIEQLD 236
           R+  +  H ++   ER  Q L+    E +  L      +R          K+D   E+ +
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486

Query: 237 KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQ 296
           + L    E     +  R + LR  QEE +   L R +++E   RL+Q L    + L REQ
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE---RLQQRLRSEQQ-LRREQ 542

Query: 297 ESAR--LQQRERE-TLEEERQALTLRLEAEQQRCCVL--QEERDAARAGQLSEHR----- 346
           E  R  L +RE E  LE+ER+   L+ E E++R  +L  +EER   R  +  E R     
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602

Query: 347 -ELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQL 405
              E  R   EE R+   ++E   +E  Q L  +S+ Q ER +++ +RE Q   E + Q 
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLL-KSEEQEERRQQQLRREQQ---ERREQR 658

Query: 406 ALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ 465
              + E  RLE  L   +RE +  + E  L +   E  R +++S +     Q  +E  A 
Sbjct: 659 LKREEEEERLEQRL---KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE--AD 713

Query: 466 AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
           A++S +      +E  R++ +    + ++E  S+L   + E A R++++++   D+  + 
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRE--SELQWQEEERAHRQQQEEEQRRDFTWQW 771

Query: 526 AREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPS 585
             E+    + + G Q+L   R  L E+ +  L+A  +E  Q     L             
Sbjct: 772 QAEE----KSERGRQRL-SARPPLREQRERQLRA--EERQQREQRFL------------- 811

Query: 586 SPGPQEPEKEERR 598
              P+E EKE+RR
Sbjct: 812 ---PEEEEKEQRR 821



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 89/382 (23%), Positives = 162/382 (42%), Gaps = 35/382 (9%)

Query: 191  DSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHE 250
            + E   ++  +R  +  + + LE ++QL       R++   +++ +  L    E     E
Sbjct: 813  EEEEKEQRRRQRREREKELQFLEEEEQLQ-----RRERAQQLQEEEDGLQEDQERRRSQE 867

Query: 251  AERTEVLRG-LQEEHQAAELT---RSKQQETVTRLEQSLSEAMEALNREQ---------- 296
              R +  R  L+EE +    T   +   QE + + +Q L E  E L RE+          
Sbjct: 868  QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927

Query: 297  ----ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLR 352
                E  +LQQ E + L EER+    +    Q R     ++++    G+  E R      
Sbjct: 928  RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR----- 982

Query: 353  AALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEV 412
               +E  + + ++E   +E  Q L+EE + +  +E E+  R+     + + QL   + E 
Sbjct: 983  --RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR 472
            RRL+      R E +  Q E  L+    E++R Q      ++ + R  E L Q +E  LR
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQ-----ELERQYRKEEELQQEEEQLLR 1095

Query: 473  QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
            +    R    ++ Q    +  Q+   QL + + E   R+E ++Q  E+ E++   EQ   
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155

Query: 533  CELQSGNQQLEEQRVELVERLQ 554
             E +   +Q  E++    E LQ
Sbjct: 1156 EEPEKRRRQELERQYREEEELQ 1177



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 133/539 (24%), Positives = 208/539 (38%), Gaps = 75/539 (13%)

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQL-----------QTMLQTSRDTAYRDP 121
            Q L R     LE+ LK+++  +   E E  R Q            Q +L++      R  
Sbjct: 588  QRLKREQEERLEQRLKREEVER--LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645

Query: 122  LIPGAGSERRE--------EDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLR 173
             +     ERRE        E+  +          R  Q+L+     QA E +  R     
Sbjct: 646  QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI---- 701

Query: 174  PGPPLNPPDFQGLRDALDSE-HTRRKHCE----RHIQSLQTRVLELQQQLAVAVAADRKK 228
               P      +   DA  S+ ++R +  E    R  Q  + R  E + Q      A R++
Sbjct: 702  ---PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758

Query: 229  DTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEA 288
                ++ D T       W     E++E  RG Q       L   ++++      Q   + 
Sbjct: 759  QEEEQRRDFT-------WQWQAEEKSE--RGRQRLSARPPLREQRERQLRAEERQQREQR 809

Query: 289  MEALNREQESARLQQRERET----LEEERQALTLRLEAEQQRCCVLQEERDAARAGQ--- 341
                  E+E  R Q+RERE     LEEE Q L  R  A+Q     LQEE D  +  Q   
Sbjct: 810  FLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQ-----LQEEEDGLQEDQERR 863

Query: 342  -LSEHRELETLRAALEEERQTWAQQ-------EHQLKEHYQALQEESQAQLEREKEKSQR 393
               E R  +  R  LEEER+            + QL++  Q LQEE + +L+RE+ + +R
Sbjct: 864  RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-ELQREEREKRR 922

Query: 394  EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV 453
              +   + + +  L Q E + L  E +  RR+    Q        + E Q +  E E   
Sbjct: 923  RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982

Query: 454  QLEQ----RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
            + E+    R  E L Q +E  LR+    R     + Q       Q+   QL + + E   
Sbjct: 983  RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042

Query: 510  REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568
             +ER++Q  E+ EL+   EQ          ++ E +R + +ER     +    E  QLL
Sbjct: 1043 LQERERQYREEEELQQEEEQLL-------GEERETRRRQELERQYRKEEELQQEEEQLL 1094



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 90/334 (26%), Positives = 150/334 (44%), Gaps = 20/334 (5%)

Query: 190  LDSEHTRRKHCERHIQS--LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247
            L+ +  RR+  ER       Q R  E QQQL       +++D    + D+ L +  E   
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR------QERDRKFRE-DEQLLQEREEQQ 1635

Query: 248  RHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERE 307
             H  ER    + L+EE Q     R +QQ    R  +   E       E++  R Q+R+R+
Sbjct: 1636 LHRQERDR--KFLEEEPQLRRQER-EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692

Query: 308  TLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEH 367
              EEE+Q     L  +++    LQEE+   R     + RE E LR   E+E+    ++  
Sbjct: 1693 FREEEQQ-----LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747

Query: 368  QLKEHYQALQEESQAQLER-EKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426
            ++ E  Q   E  + QL R E+++  RE +   + + +  L   E  R   E +  R+ER
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807

Query: 427  DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486
            +  QL       +Y  +  QL+ E   Q  ++  +R  +A+E    Q  S RE  ++  Q
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE-QELWQ 1866

Query: 487  DLSGQHQQELASQLAQFKVEMAEREE-RQQQVAE 519
            +   + +QE   +L +  +   ++EE R +QV E
Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQRHRQVGE 1900



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 109/405 (26%), Positives = 175/405 (43%), Gaps = 59/405 (14%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  +R+  ER  +  +    ELQQ+    +  +R+K            R  + W R 
Sbjct: 974  LGEEPEKRRRQEREKKYREEE--ELQQEEEQLLREEREK------------RRRQEWERQ 1019

Query: 250  EAERTEVLRGLQEEHQAAELTRSK----QQETVTRLEQSLSEAMEAL-NREQESARLQQR 304
              ++ E+    QEE Q     R K    ++E   R E+ L +  E L   E+E+ R Q+ 
Sbjct: 1020 YRKKDELQ---QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 305  ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAAL-EEERQT-- 361
            ER+  +EE     L+ E EQ      ++ R   R  Q  E  EL+     L  EER+   
Sbjct: 1077 ERQYRKEEE----LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132

Query: 362  -------WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRR 414
                   + ++E   +E  Q L+EE + +  +E E+  RE +   + + QL   + E RR
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192

Query: 415  LEGELDTARRERDALQLEMSLVQARYESQRIQL------ESELAVQ-----LEQRVTERL 463
             E E     RE + LQ +    + R E QR  L      E E AV+      + R  E+ 
Sbjct: 1193 QERE--RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250

Query: 464  AQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYEL 523
             Q ++S LR   S     ++ LQ L G+ QQE   +  + + +  +R   +++  E  E 
Sbjct: 1251 RQLEDSQLRDRQS-----QQDLQHLLGE-QQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304

Query: 524  RLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568
            + A+ + R  + Q   Q L E+R E  +R +      + E  QLL
Sbjct: 1305 KEAKRRDR--KSQEEKQLLREEREE--KRRRQETDRKFREEEQLL 1345



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 110/443 (24%), Positives = 194/443 (43%), Gaps = 80/443 (18%)

Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
           L  E    +H ++H Q  + + L+ +Q+         ++D +  +         E   RH
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQE--------ERRDWLKRE---------EETERH 467

Query: 250 EAERT-EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET 308
           E ER  + L+  QEE +     + +++E   R +Q   E  + L REQE  R +QR +  
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEER--REQQERRE--QQLRREQEERR-EQRLKRQ 522

Query: 309 LEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            EEER  L  RL +EQQ    L+ E++  R          E L    EE+R    ++E +
Sbjct: 523 EEEER--LQQRLRSEQQ----LRREQEERR----------EQLLKREEEKRLEQERREQR 566

Query: 369 LKEHYQALQEESQAQ-LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARR-ER 426
           LK      QEE + Q L+RE+E+ Q+  +   E + +  L + EV RLE E    +R +R
Sbjct: 567 LKRE----QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622

Query: 427 DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486
           +  + E      + E Q  + + +L  + ++R  +RL + +E    +    REH  ++ +
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682

Query: 487 DLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQR 546
               + +QE A +  + ++      + Q Q+  + + R ++  +R    Q G ++ +EQ 
Sbjct: 683 QELAEEEQEQARERIKSRI-----PKWQWQLESEADARQSKVYSRP-RKQEGQRRRQEQE 736

Query: 547 VELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMA 606
            E   R ++ LQ  W E  +                       Q+ E+E+RR +T    A
Sbjct: 737 -EKRRRRESELQ--WQEEER--------------------AHRQQQEEEQRRDFTWQWQA 773

Query: 607 VALKPVLQQSREARDELPGAPPV 629
                  ++S   R  L   PP+
Sbjct: 774 E------EKSERGRQRLSARPPL 790



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 91/389 (23%), Positives = 160/389 (41%), Gaps = 38/389 (9%)

Query: 184  QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243
            Q L+  L  +  R +  ER     + R    ++QL      + K+     Q +K L R  
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324

Query: 244  EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ 303
                R    R E  R  +EE Q   L + ++++ + R E+      E L  +++  +  +
Sbjct: 1325 REEKRR---RQETDRKFREEEQ---LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378

Query: 304  RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
             E+    +ER+   L+ E +Q RC    +ER+     QL + R+ +       EE Q  +
Sbjct: 1379 EEQRLRRQERERKFLK-EEQQLRC----QEREQ----QLRQDRDRK-----FREEEQQLS 1424

Query: 364  QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423
            +QE   K      +EE Q + +  + K   E Q   + +H+    + ++ +   E    R
Sbjct: 1425 RQERDRKFR----EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480

Query: 424  RERDALQLEMSLVQARYESQRIQLESELAVQ------LEQRVTERLAQAQESSLRQAASL 477
            +ERD   LE      R E  R   E EL  Q      LE+       Q Q   L++   L
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540

Query: 478  RE----HHRKQLQDLSGQHQQELASQLAQFKVEMAEREER----QQQVAEDYELRLAREQ 529
            R       R+Q +D   + +++L  +  + ++   ER+ +    +Q+V    + R   E 
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600

Query: 530  ARVCELQSGNQQLEEQRVELVERLQAMLQ 558
             +    Q G QQL ++R       + +LQ
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 103/404 (25%), Positives = 167/404 (41%), Gaps = 46/404 (11%)

Query: 190  LDSEHTRRKHCER----HIQSLQTRVLELQQQLAVAVAAD----------RKKDTMIEQL 235
            L S+   RK  E     H Q  Q + L+ +QQL                 R+++ + ++ 
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567

Query: 236  DKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAM---EAL 292
            ++      E   +   E  +V R  QE     +  + ++QE   +L Q         E L
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627

Query: 293  NREQESARL--QQRERETLEEERQALTLRLEAEQQ----RCCVLQEERDAARAGQLSEHR 346
             +E+E  +L  Q+R+R+ LEEE Q    R E EQQ    R    +EE    + G+  + R
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLR--RQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685

Query: 347  ELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLA 406
              E  R   EEE+Q   Q+  +     + LQEE Q + +  + K + E Q   ET+ +  
Sbjct: 1686 RQERDRKFREEEQQLRRQERER-----KFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740

Query: 407  LVQSEVRRL-----------EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
              Q   R++           E +L    R+R   + E  L Q R E Q    ES+   + 
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDR-KFREEEQLRQEREEQQLRSQESDRKFRE 1799

Query: 456  EQRV-TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQL---AQFKVEMAERE 511
            E+++  ER  Q      R      E  + QL++   + +QE   Q     QF  +   R 
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859

Query: 512  ERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQA 555
            E Q+   E+ + R    + ++ E     QQ EEQR   V  +++
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 104/410 (25%), Positives = 175/410 (42%), Gaps = 54/410 (13%)

Query: 187  RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
            R  L+ E   R+   R  +  +  + E ++Q       DRK     +QL +         
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ-------- 1497

Query: 247  NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306
             R    R + LR  + E +  E    +Q     R  + L E  +   +E+   R Q R+R
Sbjct: 1498 ERDRKFREQELRSQEPERKFLE--EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555

Query: 307  ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE 366
            +  EEE+    LR E E+Q+  + ++ERD     +  + R  E  R  +E+E+Q   Q+ 
Sbjct: 1556 KFREEEQ----LRQEREEQQ--LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609

Query: 367  HQ---------LKEHYQALQEESQAQLER--------EKEKSQREAQAAWETQHQLALVQ 409
             Q          +E  Q LQE  + QL R        E+E   R  +   + +H      
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669

Query: 410  SEVRRL--EGELDTARR-ERDALQLEMSLVQARYESQR--IQLESELAVQLEQRVTERLA 464
             E  +L  EGE    RR ERD    E      R E +R  +Q E +L  Q  +R      
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729

Query: 465  QAQESSLRQAASLREHHRKQLQD---LSGQHQQELASQL--AQFKVEMAEREERQQQ--- 516
            Q ++ + ++    +E +RK L++      + +Q+L  Q    +F+ E   R+ER++Q   
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789

Query: 517  -------VAEDYELRLAREQARVCELQ-SGNQQLEEQRVELVERLQAMLQ 558
                     E+ +LR  RE+ ++   Q  G  + EE++++L E+ Q + Q
Sbjct: 1790 SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 97/412 (23%), Positives = 174/412 (42%), Gaps = 56/412 (13%)

Query: 187  RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
            +D L  E  +    ER  + LQ R  +            R+++ + ++ ++ L    E  
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQY-----------REEEELQQEEEQLLGEERETR 1071

Query: 247  NRHEAERT----EVLRGLQEE--HQAAELTRSKQQETVTRLEQSLSEAMEALNREQ-ESA 299
             R E ER     E L+  +E+   +  E  R +++E   R E+ L +  E L RE+ E  
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131

Query: 300  RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLS-EHRELETLRAALEEE 358
            R Q+ ER+  EEE        E +Q+   +L+EE +  R  +L  ++RE E L+   EEE
Sbjct: 1132 RRQELERQYREEE--------EVQQEEEQLLREEPEKRRRQELERQYREEEELQQ--EEE 1181

Query: 359  RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAA-----WETQHQLALVQSEV- 412
            +    +QE + +E  +  +EE + Q ++ K++ + E Q +     WE + + A+  ++V 
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241

Query: 413  ---------RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV---------Q 454
                     R+LE   D+  R+R + Q    L+  + E  R Q                Q
Sbjct: 1242 CKGRENEQFRQLE---DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ 1298

Query: 455  LEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQ 514
            LE+   +   +    S  +   LRE   ++ +      +     QL Q + E   R + +
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358

Query: 515  QQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
             +   + ELR   +  +  E +   ++ E +R  L E  Q   Q    +  Q
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 79/345 (22%), Positives = 142/345 (41%), Gaps = 43/345 (12%)

Query: 259 GLQEEHQAA-----ELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313
           GL EE +A       L + ++QE   R  +     +E    ++   + Q++ERE  E E 
Sbjct: 94  GLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153

Query: 314 QA----------------------------LTLRLEAEQQRCCVLQEERDAARAGQLSEH 345
           Q+                               R E EQ + C   E  +     QL   
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213

Query: 346 RELETLRAALEE-ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQ 404
             LE  R   EE ++Q   +Q+   +E  +    + +  L +E+EK Q E     E Q Q
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE-----EPQRQ 268

Query: 405 LALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLA 464
             L + E +  + E    RRER   + +   ++   + +R Q E E   Q E+R  ++  
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ-EEERREQQEERREQQER 327

Query: 465 QAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREE---RQQQVAEDY 521
           + Q+   R+    RE   ++ Q L  + ++E   Q  + + E   RE+   R+QQ+  + 
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387

Query: 522 ELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
           +LR  ++  R  +L+   Q   EQ++   ++L+   Q   ++  +
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 114/508 (22%), Positives = 200/508 (39%), Gaps = 76/508 (14%)

Query: 69   DGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGS 128
            D   QE  + L    EK  + ++  +   E E ++ + + +L   R+T  R  L      
Sbjct: 1024 DELQQEEEQLLREEREKR-RLQERERQYREEEELQQEEEQLLGEERETRRRQEL----ER 1078

Query: 129  ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
            + R+E+    +    LL   P +        Q  EE             L   + Q LR+
Sbjct: 1079 QYRKEEELQQEEEQ-LLREEPEKRRRQERERQCREE-----------EELQQEEEQLLRE 1126

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTM---------IEQLDKTL 239
              + E  RR+  ER  +  +  V + ++QL       R++  +         ++Q ++ L
Sbjct: 1127 --EREKRRRQELERQYRE-EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183

Query: 240  ARVVEGWNRHEAERT-----EVLRGLQEEHQAAELTRS--KQQETVTRLEQSLSEAMEAL 292
             R  +   R E ER      E+ R  +++    E  RS  K Q    +        +   
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243

Query: 293  NREQESARL----QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHREL 348
             RE E  R     Q R+R++ ++ +  L      EQQ       ERD             
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLL-----GEQQ-------ERDR------------ 1279

Query: 349  ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408
                   E+ER+ W Q++    E  Q L+ E Q + +R   KSQ E Q   E + +    
Sbjct: 1280 -------EQERRRWQQRDRHFPEEEQ-LEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331

Query: 409  QSEVRRL-EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQ 467
            Q   R+  E E     RE   L+ +    + R E  R Q +    ++ EQR+  R  + +
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL--RRQERE 1389

Query: 468  ESSLRQAASLR-EHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLA 526
               L++   LR +   +QL+    +  +E   QL++ + +   REE QQ   ++ E +  
Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFL 1449

Query: 527  REQARVCELQSGNQQLEEQRVELVERLQ 554
             E+ ++ + +    + EEQ ++  E  Q
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQ 1477



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 57/273 (20%), Positives = 117/273 (42%), Gaps = 18/273 (6%)

Query: 297 ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE 356
           ++  L + +R   + +   L  R + E QR    ++ +     GQ    +  E  R   E
Sbjct: 91  QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150

Query: 357 EERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWETQHQLALVQSEVR 413
            E Q+  Q+  + ++  +  +E   + Q   ERE+ +++ E   + +          E  
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210

Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473
           R    L+  R+ R+  Q      Q R    R+  E E   + E R  E + + +E  L++
Sbjct: 211 RRRELLELRRKGREEKQ-----QQRRERQDRVFQEEE---EKEWRKRETVLRKEEEKLQE 262

Query: 474 AASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVC 533
               R+      ++L  + +Q    +  + + E  E E++QQ++  + +LR  +E+ R  
Sbjct: 263 EEPQRQ------RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER-R 315

Query: 534 ELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
           E Q   ++ +E+R +  ER +  L+   +E  +
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERRE 348



 Score = 37.0 bits (84), Expect = 0.085
 Identities = 48/178 (26%), Positives = 78/178 (43%), Gaps = 18/178 (10%)

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRK---KDTMIEQLDKTLARV 242
            LR   + E  RR+   R I   +    E ++Q       DRK   ++ + ++ ++   R 
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790

Query: 243  VEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL- 301
             E   +   E  E LR  +EE Q     R +Q++   R E+      E L  E++  RL 
Sbjct: 1791 QESDRKFREE--EQLRQEREEQQL----RPQQRDGKYRWEE------EQLQLEEQEQRLR 1838

Query: 302  QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER 359
            Q+R+R+   EE+ A   +   E+Q   + QEE    R  +  + RE    R   EE+R
Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQE--LWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  104 bits (259), Expect = 4e-22
 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
            R + E  ++S +   LE  +Q  +A   +R++    E++ K+LA   E   + +A   EV
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 257  LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
             R   +  +A  L    +QE+  +L+ +   A + L  E+++    +QQ+E+E   TL++
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 312  ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E+  L  LR EAE  R          +Q ER+AA++ +  E  E E L+ + EE+ Q  A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2129

Query: 364  QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
            Q +                + +    AL+++  A  E EK K       +++AQ   E  
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189

Query: 401  --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
                    T HQ  L+  E++RL+ E   A R+R  ++ E+  V+ + E       RI+ 
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
            E+   +  ++  T+R  Q +   ++Q A      S+      +L+ L+ +    Q+ LA 
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 499  QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
            ++ + K++  +   R +  AE    +  LA+EQAR   LQ   +Q+ +Q  E  +  Q  
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2367

Query: 557  LQA 559
            L+A
Sbjct: 2368 LEA 2370



 Score =  103 bits (256), Expect = 1e-21
 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
            A+D++  +R   E   Q  Q+   E+Q +   A AA+R +   IE+  + +   +E   R
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1466

Query: 249  HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
                    L+ L+   + AE  + + QE   RL + +            E    +  E E
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 298  SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
            +AR +QR  + LEE      LRL+AE+    + Q E + AR  Q++      +  A L+ 
Sbjct: 1527 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580

Query: 358  ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
            +R ++A++  QL+   ++LQEE  A + + +E+++R AQ   E +      + E+ R + 
Sbjct: 1581 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1635

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
                  +  +AL+L +   +   +    Q E+E   +  +R   R  +A+E ++RQ    
Sbjct: 1636 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690

Query: 478  REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
             +   KQ Q   G  QQ LA+  +L + + E  E+ E+Q+Q+ E+   RL RE A   + 
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1749

Query: 536  QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
            +   Q+LE +  ++   ++ +L +      +  ST              S    Q  E E
Sbjct: 1750 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1792

Query: 596  ERRVWTMPPMAVALKPVLQQSREAR 620
              R   +   A  L+ + ++++  R
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQR 1817



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)

Query: 13   GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
            GAE++L    E     Q       +L A+    ++  A A AQ             D   
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1150

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
             EL  +  VG  + L+++ G + + E+E  R ++  +L+  +     T  R   +   G 
Sbjct: 1151 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207

Query: 129  ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
            + R          A L + R  Q+     P + +QA+ E   +               Q 
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1253

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
            L + ++    + + C+R  +     + + + QL         VA+  KK  +    +  +
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313

Query: 240  ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
               V+    H +E T           E LR ++EE + AE  R++++E +  +E +L + 
Sbjct: 1314 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372

Query: 288  -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
                   A      E+E+  LQQR +E +    +A    ++A+QQ+  + +E        
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1429

Query: 333  ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
                     + +AA   +L    E+  +R  LE   +     E +L+   +A  EE++AQ
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1488

Query: 384  LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
              + +E+++R   Q   E+Q +         R++ E + AR ++ ALQ LE   +QA   
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
             +R++   +  V+  ++V   L  AQ S+  +  S R    ++   L    Q+E  + +A
Sbjct: 1549 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1604

Query: 502  QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
            Q + E AER  +QQ  AE      ARE+A         ++LE  +++  E L+  LQA  
Sbjct: 1605 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1648

Query: 562  DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
            +E  Q  S               +    +E E+E RR       AV  + + +Q  E + 
Sbjct: 1649 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 622  EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
            +L  G      ++  +L  L   + Q +   Q LE
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)

Query: 45   SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
            +RQAEA  R++L +              +E  R + + LE   +++ G++   E++++R 
Sbjct: 1437 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1480

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            + +      R        +     +  +         A+ +            + QALEE
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
            L  R  +      L   + +  R    +  T ++  E  +QS +    E   QL      
Sbjct: 1541 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 220  --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
              VAVA     A+R+  +    E+  +   R +E W   + +  E LR   +  + A+  
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1655

Query: 271  RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
               Q E   + E++  EA      E+++ R ++   + LE++RQ                
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715

Query: 316  LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            + LR E EQ  Q+  +L+EE     R+AA A Q  + +ELE   A +  E +     + +
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1773

Query: 369  LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
             +E  ++  E+S+ +LE E   + R  + A E     AL +   R+ +  E D AR+  +
Sbjct: 1774 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
            A ++    + A  E+ R++ E+E+A++ ++   ERL +  E    Q        R++L++
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1882

Query: 488  LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
             + QH+ ++  +LAQ +       ERQ+ + ED   +  + +  +  L++  ++    + 
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942

Query: 548  EL 549
            EL
Sbjct: 1943 EL 1944



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)

Query: 213  ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
            ELQ+  A A  A R++  + E+L            R + E    L+   E    A + R 
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2258

Query: 273  KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            K       QE   +++Q   EA       QE+ARL+Q   E L ++R      L+ + Q 
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2317

Query: 327  CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
              V +  R  A A  L + +EL   +A  L+E+++  AQQ  +  + +Q  L+ E Q QL
Sbjct: 2318 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376

Query: 385  E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
            E                    R +E +QR  + A E           TQ ++ LVQ+ E+
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
            +R + + D  R      +LE    + + E++ +QL+SE    VQ EQ + E  A  Q+S 
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2495

Query: 471  LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
            L +  SL +  R                    +QL++   + QQ++  +  +    M E 
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 511  EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
              RQ +  E       EL+   +Q R  E  L   NQ+L EQ ++L+E       AH +E
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2614

Query: 564  --ANQLLST-TLP 573
              A+Q+ +T TLP
Sbjct: 2615 VTASQVAATKTLP 2627



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)

Query: 215  QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
            Q+QLA   AA R++      L + LA + E    + EAE          E LR L E+  
Sbjct: 1816 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874

Query: 266  AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
                 R + +E   + +  + E +  L +  +S   +Q        R+R  +EEE  AL 
Sbjct: 1875 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
               E               A AG+     EL  +R+  E+  ++  Q E +     Q   
Sbjct: 1932 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977

Query: 378  EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
            EE + + E E E+ Q+   A  E   Q      EV RL+ +++ ARR R+         L
Sbjct: 1978 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036

Query: 430  QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
            QL     Q R ++         Q+ + E +  +Q EQ V ++L + +  + R+AA   E 
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2095

Query: 481  HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
             R Q +  + Q   Q E A +L Q   E A+   + Q  AE       +E AR       
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2148

Query: 539  NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
              Q E+  +   +   A ++ H   A Q L
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  + K        L     E  +   +A     ++  + E++ K   + V+   R 
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            +AE       LQ++ + A+    + QE   ++ Q L+E  +   R  E+ R +Q E   +
Sbjct: 2326 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2378

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
              E + L LR+ AE  R     EE DA R  + +E    +  R  L  +E+ T  Q    
Sbjct: 2379 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436

Query: 366  EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
            + Q  +H      E+ A+LEREKEK Q+EA+       ++  VQ E  ++  +    +  
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 424  RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
             E+D+L Q E  + Q + + +++ Q E   A QL +    +  Q ++   R  AS+ E  
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 482  RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            R+Q                L+    Q ++ LA +  + + ++   EE+ +      E   
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616

Query: 526  AREQARVCELQSGNQQLEEQRVE 548
            A + A    L +G   L+    E
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAE 2639



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)

Query: 311  EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
            +E Q    RLEA+ Q    L  +           +   R  QL     L T R    EE+
Sbjct: 863  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922

Query: 360  QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
            +   Q  H L+ HYQA   +SQ             ERE        Q   ++  Q A  +
Sbjct: 923  R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
            S  +R   EL   R     LQLE    +  +   R+ L+ E A +  QR+ E + AQA+ 
Sbjct: 980  SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1033

Query: 469  SSL 471
              L
Sbjct: 1034 EGL 1036


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  104 bits (259), Expect = 4e-22
 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
            R + E  ++S +   LE  +Q  +A   +R++    E++ K+LA   E   + +A   EV
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015

Query: 257  LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
             R   +  +A  L    +QE+  +L+ +   A + L  E+++    +QQ+E+E   TL++
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075

Query: 312  ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E+  L  LR EAE  R          +Q ER+AA++ +  E  E E L+ + EE+ Q  A
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2133

Query: 364  QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
            Q +                + +    AL+++  A  E EK K       +++AQ   E  
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193

Query: 401  --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
                    T HQ  L+  E++RL+ E   A R+R  ++ E+  V+ + E       RI+ 
Sbjct: 2194 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2253

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
            E+   +  ++  T+R  Q +   ++Q A      S+      +L+ L+ +    Q+ LA 
Sbjct: 2254 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313

Query: 499  QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
            ++ + K++  +   R +  AE    +  LA+EQAR   LQ   +Q+ +Q  E  +  Q  
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2371

Query: 557  LQA 559
            L+A
Sbjct: 2372 LEA 2374



 Score =  103 bits (256), Expect = 1e-21
 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
            A+D++  +R   E   Q  Q+   E+Q +   A AA+R +   IE+  + +   +E   R
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1470

Query: 249  HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
                    L+ L+   + AE  + + QE   RL + +            E    +  E E
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530

Query: 298  SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
            +AR +QR  + LEE      LRL+AE+    + Q E + AR  Q++      +  A L+ 
Sbjct: 1531 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584

Query: 358  ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
            +R ++A++  QL+   ++LQEE  A + + +E+++R AQ   E +      + E+ R + 
Sbjct: 1585 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1639

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
                  +  +AL+L +   +   +    Q E+E   +  +R   R  +A+E ++RQ    
Sbjct: 1640 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1694

Query: 478  REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
             +   KQ Q   G  QQ LA+  +L + + E  E+ E+Q+Q+ E+   RL RE A   + 
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1753

Query: 536  QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
            +   Q+LE +  ++   ++ +L +      +  ST              S    Q  E E
Sbjct: 1754 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1796

Query: 596  ERRVWTMPPMAVALKPVLQQSREAR 620
              R   +   A  L+ + ++++  R
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQR 1821



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)

Query: 13   GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
            GAE++L    E     Q       +L A+    ++  A A AQ             D   
Sbjct: 1104 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1154

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
             EL  +  VG  + L+++ G + + E+E  R ++  +L+  +     T  R   +   G 
Sbjct: 1155 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211

Query: 129  ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
            + R          A L + R  Q+     P + +QA+ E   +               Q 
Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1257

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
            L + ++    + + C+R  +     + + + QL         VA+  KK  +    +  +
Sbjct: 1258 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1317

Query: 240  ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
               V+    H +E T           E LR ++EE + AE  R++++E +  +E +L + 
Sbjct: 1318 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1376

Query: 288  -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
                   A      E+E+  LQQR +E +    +A    ++A+QQ+  + +E        
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1433

Query: 333  ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
                     + +AA   +L    E+  +R  LE   +     E +L+   +A  EE++AQ
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1492

Query: 384  LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
              + +E+++R   Q   E+Q +         R++ E + AR ++ ALQ LE   +QA   
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
             +R++   +  V+  ++V   L  AQ S+  +  S R    ++   L    Q+E  + +A
Sbjct: 1553 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1608

Query: 502  QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
            Q + E AER  +QQ  AE      ARE+A         ++LE  +++  E L+  LQA  
Sbjct: 1609 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1652

Query: 562  DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
            +E  Q  S               +    +E E+E RR       AV  + + +Q  E + 
Sbjct: 1653 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702

Query: 622  EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
            +L  G      ++  +L  L   + Q +   Q LE
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)

Query: 45   SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
            +RQAEA  R++L +              +E  R + + LE   +++ G++   E++++R 
Sbjct: 1441 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1484

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            + +      R        +     +  +         A+ +            + QALEE
Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
            L  R  +      L   + +  R    +  T ++  E  +QS +    E   QL      
Sbjct: 1545 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602

Query: 220  --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
              VAVA     A+R+  +    E+  +   R +E W   + +  E LR   +  + A+  
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1659

Query: 271  RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
               Q E   + E++  EA      E+++ R ++   + LE++RQ                
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719

Query: 316  LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            + LR E EQ  Q+  +L+EE     R+AA A Q  + +ELE   A +  E +     + +
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1777

Query: 369  LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
             +E  ++  E+S+ +LE E   + R  + A E     AL +   R+ +  E D AR+  +
Sbjct: 1778 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
            A ++    + A  E+ R++ E+E+A++ ++   ERL +  E    Q        R++L++
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1886

Query: 488  LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
             + QH+ ++  +LAQ +       ERQ+ + ED   +  + +  +  L++  ++    + 
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946

Query: 548  EL 549
            EL
Sbjct: 1947 EL 1948



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)

Query: 213  ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
            ELQ+  A A  A R++  + E+L            R + E    L+   E    A + R 
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2262

Query: 273  KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            K       QE   +++Q   EA       QE+ARL+Q   E L ++R      L+ + Q 
Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2321

Query: 327  CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
              V +  R  A A  L + +EL   +A  L+E+++  AQQ  +  + +Q  L+ E Q QL
Sbjct: 2322 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380

Query: 385  E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
            E                    R +E +QR  + A E           TQ ++ LVQ+ E+
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
            +R + + D  R      +LE    + + E++ +QL+SE    VQ EQ + E  A  Q+S 
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2499

Query: 471  LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
            L +  SL +  R                    +QL++   + QQ++  +  +    M E 
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559

Query: 511  EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
              RQ +  E       EL+   +Q R  E  L   NQ+L EQ ++L+E       AH +E
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2618

Query: 564  --ANQLLST-TLP 573
              A+Q+ +T TLP
Sbjct: 2619 VTASQVAATKTLP 2631



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)

Query: 215  QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
            Q+QLA   AA R++      L + LA + E    + EAE          E LR L E+  
Sbjct: 1820 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878

Query: 266  AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
                 R + +E   + +  + E +  L +  +S   +Q        R+R  +EEE  AL 
Sbjct: 1879 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
               E               A AG+     EL  +R+  E+  ++  Q E +     Q   
Sbjct: 1936 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1981

Query: 378  EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
            EE + + E E E+ Q+   A  E   Q      EV RL+ +++ ARR R+         L
Sbjct: 1982 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040

Query: 430  QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
            QL     Q R ++         Q+ + E +  +Q EQ V ++L + +  + R+AA   E 
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2099

Query: 481  HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
             R Q +  + Q   Q E A +L Q   E A+   + Q  AE       +E AR       
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2152

Query: 539  NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
              Q E+  +   +   A ++ H   A Q L
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  + K        L     E  +   +A     ++  + E++ K   + V+   R 
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            +AE       LQ++ + A+    + QE   ++ Q L+E  +   R  E+ R +Q E   +
Sbjct: 2330 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2382

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
              E + L LR+ AE  R     EE DA R  + +E    +  R  L  +E+ T  Q    
Sbjct: 2383 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440

Query: 366  EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
            + Q  +H      E+ A+LEREKEK Q+EA+       ++  VQ E  ++  +    +  
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500

Query: 424  RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
             E+D+L Q E  + Q + + +++ Q E   A QL +    +  Q ++   R  AS+ E  
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560

Query: 482  RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            R+Q                L+    Q ++ LA +  + + ++   EE+ +      E   
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620

Query: 526  AREQARVCELQSGNQQLEEQRVE 548
            A + A    L +G   L+    E
Sbjct: 2621 ASQVAATKTLPNGRDALDGPAAE 2643



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)

Query: 311  EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
            +E Q    RLEA+ Q    L  +           +   R  QL     L T R    EE+
Sbjct: 867  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 926

Query: 360  QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
            +   Q  H L+ HYQA   +SQ             ERE        Q   ++  Q A  +
Sbjct: 927  R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 983

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
            S  +R   EL   R     LQLE    +  +   R+ L+ E A +  QR+ E + AQA+ 
Sbjct: 984  SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1037

Query: 469  SSL 471
              L
Sbjct: 1038 EGL 1040


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  104 bits (259), Expect = 4e-22
 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
            R + E  ++S +   LE  +Q  +A   +R++    E++ K+LA   E   + +A   EV
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 257  LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
             R   +  +A  L    +QE+  +L+ +   A + L  E+++    +QQ+E+E   TL++
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 312  ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E+  L  LR EAE  R          +Q ER+AA++ +  E  E E L+ + EE+ Q  A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2129

Query: 364  QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
            Q +                + +    AL+++  A  E EK K       +++AQ   E  
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189

Query: 401  --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
                    T HQ  L+  E++RL+ E   A R+R  ++ E+  V+ + E       RI+ 
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
            E+   +  ++  T+R  Q +   ++Q A      S+      +L+ L+ +    Q+ LA 
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309

Query: 499  QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
            ++ + K++  +   R +  AE    +  LA+EQAR   LQ   +Q+ +Q  E  +  Q  
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2367

Query: 557  LQA 559
            L+A
Sbjct: 2368 LEA 2370



 Score =  103 bits (256), Expect = 1e-21
 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
            A+D++  +R   E   Q  Q+   E+Q +   A AA+R +   IE+  + +   +E   R
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1466

Query: 249  HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
                    L+ L+   + AE  + + QE   RL + +            E    +  E E
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 298  SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
            +AR +QR  + LEE      LRL+AE+    + Q E + AR  Q++      +  A L+ 
Sbjct: 1527 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580

Query: 358  ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
            +R ++A++  QL+   ++LQEE  A + + +E+++R AQ   E +      + E+ R + 
Sbjct: 1581 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1635

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
                  +  +AL+L +   +   +    Q E+E   +  +R   R  +A+E ++RQ    
Sbjct: 1636 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690

Query: 478  REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
             +   KQ Q   G  QQ LA+  +L + + E  E+ E+Q+Q+ E+   RL RE A   + 
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1749

Query: 536  QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
            +   Q+LE +  ++   ++ +L +      +  ST              S    Q  E E
Sbjct: 1750 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1792

Query: 596  ERRVWTMPPMAVALKPVLQQSREAR 620
              R   +   A  L+ + ++++  R
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQR 1817



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)

Query: 13   GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
            GAE++L    E     Q       +L A+    ++  A A AQ             D   
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1150

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
             EL  +  VG  + L+++ G + + E+E  R ++  +L+  +     T  R   +   G 
Sbjct: 1151 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207

Query: 129  ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
            + R          A L + R  Q+     P + +QA+ E   +               Q 
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1253

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
            L + ++    + + C+R  +     + + + QL         VA+  KK  +    +  +
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313

Query: 240  ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
               V+    H +E T           E LR ++EE + AE  R++++E +  +E +L + 
Sbjct: 1314 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372

Query: 288  -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
                   A      E+E+  LQQR +E +    +A    ++A+QQ+  + +E        
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1429

Query: 333  ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
                     + +AA   +L    E+  +R  LE   +     E +L+   +A  EE++AQ
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1488

Query: 384  LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
              + +E+++R   Q   E+Q +         R++ E + AR ++ ALQ LE   +QA   
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
             +R++   +  V+  ++V   L  AQ S+  +  S R    ++   L    Q+E  + +A
Sbjct: 1549 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1604

Query: 502  QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
            Q + E AER  +QQ  AE      ARE+A         ++LE  +++  E L+  LQA  
Sbjct: 1605 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1648

Query: 562  DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
            +E  Q  S               +    +E E+E RR       AV  + + +Q  E + 
Sbjct: 1649 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 622  EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
            +L  G      ++  +L  L   + Q +   Q LE
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)

Query: 45   SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
            +RQAEA  R++L +              +E  R + + LE   +++ G++   E++++R 
Sbjct: 1437 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1480

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            + +      R        +     +  +         A+ +            + QALEE
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
            L  R  +      L   + +  R    +  T ++  E  +QS +    E   QL      
Sbjct: 1541 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 220  --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
              VAVA     A+R+  +    E+  +   R +E W   + +  E LR   +  + A+  
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1655

Query: 271  RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
               Q E   + E++  EA      E+++ R ++   + LE++RQ                
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715

Query: 316  LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            + LR E EQ  Q+  +L+EE     R+AA A Q  + +ELE   A +  E +     + +
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1773

Query: 369  LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
             +E  ++  E+S+ +LE E   + R  + A E     AL +   R+ +  E D AR+  +
Sbjct: 1774 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
            A ++    + A  E+ R++ E+E+A++ ++   ERL +  E    Q        R++L++
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1882

Query: 488  LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
             + QH+ ++  +LAQ +       ERQ+ + ED   +  + +  +  L++  ++    + 
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942

Query: 548  EL 549
            EL
Sbjct: 1943 EL 1944



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)

Query: 213  ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
            ELQ+  A A  A R++  + E+L            R + E    L+   E    A + R 
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2258

Query: 273  KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            K       QE   +++Q   EA       QE+ARL+Q   E L ++R      L+ + Q 
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2317

Query: 327  CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
              V +  R  A A  L + +EL   +A  L+E+++  AQQ  +  + +Q  L+ E Q QL
Sbjct: 2318 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376

Query: 385  E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
            E                    R +E +QR  + A E           TQ ++ LVQ+ E+
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
            +R + + D  R      +LE    + + E++ +QL+SE    VQ EQ + E  A  Q+S 
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2495

Query: 471  LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
            L +  SL +  R                    +QL++   + QQ++  +  +    M E 
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555

Query: 511  EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
              RQ +  E       EL+   +Q R  E  L   NQ+L EQ ++L+E       AH +E
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2614

Query: 564  --ANQLLST-TLP 573
              A+Q+ +T TLP
Sbjct: 2615 VTASQVAATKTLP 2627



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)

Query: 215  QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
            Q+QLA   AA R++      L + LA + E    + EAE          E LR L E+  
Sbjct: 1816 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874

Query: 266  AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
                 R + +E   + +  + E +  L +  +S   +Q        R+R  +EEE  AL 
Sbjct: 1875 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
               E               A AG+     EL  +R+  E+  ++  Q E +     Q   
Sbjct: 1932 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977

Query: 378  EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
            EE + + E E E+ Q+   A  E   Q      EV RL+ +++ ARR R+         L
Sbjct: 1978 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036

Query: 430  QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
            QL     Q R ++         Q+ + E +  +Q EQ V ++L + +  + R+AA   E 
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2095

Query: 481  HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
             R Q +  + Q   Q E A +L Q   E A+   + Q  AE       +E AR       
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2148

Query: 539  NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
              Q E+  +   +   A ++ H   A Q L
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  + K        L     E  +   +A     ++  + E++ K   + V+   R 
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            +AE       LQ++ + A+    + QE   ++ Q L+E  +   R  E+ R +Q E   +
Sbjct: 2326 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2378

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
              E + L LR+ AE  R     EE DA R  + +E    +  R  L  +E+ T  Q    
Sbjct: 2379 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436

Query: 366  EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
            + Q  +H      E+ A+LEREKEK Q+EA+       ++  VQ E  ++  +    +  
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 424  RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
             E+D+L Q E  + Q + + +++ Q E   A QL +    +  Q ++   R  AS+ E  
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 482  RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            R+Q                L+    Q ++ LA +  + + ++   EE+ +      E   
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616

Query: 526  AREQARVCELQSGNQQLEEQRVE 548
            A + A    L +G   L+    E
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAE 2639



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)

Query: 311  EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
            +E Q    RLEA+ Q    L  +           +   R  QL     L T R    EE+
Sbjct: 863  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922

Query: 360  QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
            +   Q  H L+ HYQA   +SQ             ERE        Q   ++  Q A  +
Sbjct: 923  R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
            S  +R   EL   R     LQLE    +  +   R+ L+ E A +  QR+ E + AQA+ 
Sbjct: 980  SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1033

Query: 469  SSL 471
              L
Sbjct: 1034 EGL 1036


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  104 bits (259), Expect = 4e-22
 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
            R + E  ++S +   LE  +Q  +A   +R++    E++ K+LA   E   + +A   EV
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979

Query: 257  LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
             R   +  +A  L    +QE+  +L+ +   A + L  E+++    +QQ+E+E   TL++
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039

Query: 312  ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E+  L  LR EAE  R          +Q ER+AA++ +  E  E E L+ + EE+ Q  A
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2097

Query: 364  QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
            Q +                + +    AL+++  A  E EK K       +++AQ   E  
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157

Query: 401  --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
                    T HQ  L+  E++RL+ E   A R+R  ++ E+  V+ + E       RI+ 
Sbjct: 2158 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2217

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
            E+   +  ++  T+R  Q +   ++Q A      S+      +L+ L+ +    Q+ LA 
Sbjct: 2218 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277

Query: 499  QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
            ++ + K++  +   R +  AE    +  LA+EQAR   LQ   +Q+ +Q  E  +  Q  
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2335

Query: 557  LQA 559
            L+A
Sbjct: 2336 LEA 2338



 Score =  103 bits (256), Expect = 1e-21
 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
            A+D++  +R   E   Q  Q+   E+Q +   A AA+R +   IE+  + +   +E   R
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1434

Query: 249  HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
                    L+ L+   + AE  + + QE   RL + +            E    +  E E
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494

Query: 298  SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
            +AR +QR  + LEE      LRL+AE+    + Q E + AR  Q++      +  A L+ 
Sbjct: 1495 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548

Query: 358  ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
            +R ++A++  QL+   ++LQEE  A + + +E+++R AQ   E +      + E+ R + 
Sbjct: 1549 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1603

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
                  +  +AL+L +   +   +    Q E+E   +  +R   R  +A+E ++RQ    
Sbjct: 1604 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1658

Query: 478  REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
             +   KQ Q   G  QQ LA+  +L + + E  E+ E+Q+Q+ E+   RL RE A   + 
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1717

Query: 536  QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
            +   Q+LE +  ++   ++ +L +      +  ST              S    Q  E E
Sbjct: 1718 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1760

Query: 596  ERRVWTMPPMAVALKPVLQQSREAR 620
              R   +   A  L+ + ++++  R
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQR 1785



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)

Query: 13   GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
            GAE++L    E     Q       +L A+    ++  A A AQ             D   
Sbjct: 1068 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1118

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
             EL  +  VG  + L+++ G + + E+E  R ++  +L+  +     T  R   +   G 
Sbjct: 1119 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175

Query: 129  ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
            + R          A L + R  Q+     P + +QA+ E   +               Q 
Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1221

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
            L + ++    + + C+R  +     + + + QL         VA+  KK  +    +  +
Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281

Query: 240  ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
               V+    H +E T           E LR ++EE + AE  R++++E +  +E +L + 
Sbjct: 1282 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1340

Query: 288  -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
                   A      E+E+  LQQR +E +    +A    ++A+QQ+  + +E        
Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1397

Query: 333  ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
                     + +AA   +L    E+  +R  LE   +     E +L+   +A  EE++AQ
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1456

Query: 384  LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
              + +E+++R   Q   E+Q +         R++ E + AR ++ ALQ LE   +QA   
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
             +R++   +  V+  ++V   L  AQ S+  +  S R    ++   L    Q+E  + +A
Sbjct: 1517 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1572

Query: 502  QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
            Q + E AER  +QQ  AE      ARE+A         ++LE  +++  E L+  LQA  
Sbjct: 1573 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1616

Query: 562  DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
            +E  Q  S               +    +E E+E RR       AV  + + +Q  E + 
Sbjct: 1617 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666

Query: 622  EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
            +L  G      ++  +L  L   + Q +   Q LE
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)

Query: 45   SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
            +RQAEA  R++L +              +E  R + + LE   +++ G++   E++++R 
Sbjct: 1405 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1448

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            + +      R        +     +  +         A+ +            + QALEE
Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
            L  R  +      L   + +  R    +  T ++  E  +QS +    E   QL      
Sbjct: 1509 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566

Query: 220  --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
              VAVA     A+R+  +    E+  +   R +E W   + +  E LR   +  + A+  
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1623

Query: 271  RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
               Q E   + E++  EA      E+++ R ++   + LE++RQ                
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683

Query: 316  LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            + LR E EQ  Q+  +L+EE     R+AA A Q  + +ELE   A +  E +     + +
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1741

Query: 369  LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
             +E  ++  E+S+ +LE E   + R  + A E     AL +   R+ +  E D AR+  +
Sbjct: 1742 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
            A ++    + A  E+ R++ E+E+A++ ++   ERL +  E    Q        R++L++
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1850

Query: 488  LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
             + QH+ ++  +LAQ +       ERQ+ + ED   +  + +  +  L++  ++    + 
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910

Query: 548  EL 549
            EL
Sbjct: 1911 EL 1912



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)

Query: 213  ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
            ELQ+  A A  A R++  + E+L            R + E    L+   E    A + R 
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2226

Query: 273  KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            K       QE   +++Q   EA       QE+ARL+Q   E L ++R      L+ + Q 
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2285

Query: 327  CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
              V +  R  A A  L + +EL   +A  L+E+++  AQQ  +  + +Q  L+ E Q QL
Sbjct: 2286 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344

Query: 385  E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
            E                    R +E +QR  + A E           TQ ++ LVQ+ E+
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
            +R + + D  R      +LE    + + E++ +QL+SE    VQ EQ + E  A  Q+S 
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2463

Query: 471  LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
            L +  SL +  R                    +QL++   + QQ++  +  +    M E 
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523

Query: 511  EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
              RQ +  E       EL+   +Q R  E  L   NQ+L EQ ++L+E       AH +E
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2582

Query: 564  --ANQLLST-TLP 573
              A+Q+ +T TLP
Sbjct: 2583 VTASQVAATKTLP 2595



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)

Query: 215  QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
            Q+QLA   AA R++      L + LA + E    + EAE          E LR L E+  
Sbjct: 1784 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842

Query: 266  AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
                 R + +E   + +  + E +  L +  +S   +Q        R+R  +EEE  AL 
Sbjct: 1843 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
               E               A AG+     EL  +R+  E+  ++  Q E +     Q   
Sbjct: 1900 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1945

Query: 378  EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
            EE + + E E E+ Q+   A  E   Q      EV RL+ +++ ARR R+         L
Sbjct: 1946 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004

Query: 430  QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
            QL     Q R ++         Q+ + E +  +Q EQ V ++L + +  + R+AA   E 
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2063

Query: 481  HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
             R Q +  + Q   Q E A +L Q   E A+   + Q  AE       +E AR       
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2116

Query: 539  NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
              Q E+  +   +   A ++ H   A Q L
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  + K        L     E  +   +A     ++  + E++ K   + V+   R 
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            +AE       LQ++ + A+    + QE   ++ Q L+E  +   R  E+ R +Q E   +
Sbjct: 2294 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2346

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
              E + L LR+ AE  R     EE DA R  + +E    +  R  L  +E+ T  Q    
Sbjct: 2347 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404

Query: 366  EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
            + Q  +H      E+ A+LEREKEK Q+EA+       ++  VQ E  ++  +    +  
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464

Query: 424  RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
             E+D+L Q E  + Q + + +++ Q E   A QL +    +  Q ++   R  AS+ E  
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524

Query: 482  RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            R+Q                L+    Q ++ LA +  + + ++   EE+ +      E   
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584

Query: 526  AREQARVCELQSGNQQLEEQRVE 548
            A + A    L +G   L+    E
Sbjct: 2585 ASQVAATKTLPNGRDALDGPAAE 2607



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)

Query: 311  EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
            +E Q    RLEA+ Q    L  +           +   R  QL     L T R    EE+
Sbjct: 831  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 890

Query: 360  QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
            +   Q  H L+ HYQA   +SQ             ERE        Q   ++  Q A  +
Sbjct: 891  R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 947

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
            S  +R   EL   R     LQLE    +  +   R+ L+ E A +  QR+ E + AQA+ 
Sbjct: 948  SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1001

Query: 469  SSL 471
              L
Sbjct: 1002 EGL 1004


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  104 bits (259), Expect = 4e-22
 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
            R + E  ++S +   LE  +Q  +A   +R++    E++ K+LA   E   + +A   EV
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148

Query: 257  LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
             R   +  +A  L    +QE+  +L+ +   A + L  E+++    +QQ+E+E   TL++
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208

Query: 312  ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E+  L  LR EAE  R          +Q ER+AA++ +  E  E E L+ + EE+ Q  A
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2266

Query: 364  QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
            Q +                + +    AL+++  A  E EK K       +++AQ   E  
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326

Query: 401  --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
                    T HQ  L+  E++RL+ E   A R+R  ++ E+  V+ + E       RI+ 
Sbjct: 2327 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2386

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
            E+   +  ++  T+R  Q +   ++Q A      S+      +L+ L+ +    Q+ LA 
Sbjct: 2387 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446

Query: 499  QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
            ++ + K++  +   R +  AE    +  LA+EQAR   LQ   +Q+ +Q  E  +  Q  
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2504

Query: 557  LQA 559
            L+A
Sbjct: 2505 LEA 2507



 Score =  103 bits (256), Expect = 1e-21
 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
            A+D++  +R   E   Q  Q+   E+Q +   A AA+R +   IE+  + +   +E   R
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1603

Query: 249  HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
                    L+ L+   + AE  + + QE   RL + +            E    +  E E
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663

Query: 298  SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
            +AR +QR  + LEE      LRL+AE+    + Q E + AR  Q++      +  A L+ 
Sbjct: 1664 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717

Query: 358  ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
            +R ++A++  QL+   ++LQEE  A + + +E+++R AQ   E +      + E+ R + 
Sbjct: 1718 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1772

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
                  +  +AL+L +   +   +    Q E+E   +  +R   R  +A+E ++RQ    
Sbjct: 1773 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827

Query: 478  REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
             +   KQ Q   G  QQ LA+  +L + + E  E+ E+Q+Q+ E+   RL RE A   + 
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1886

Query: 536  QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
            +   Q+LE +  ++   ++ +L +      +  ST              S    Q  E E
Sbjct: 1887 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1929

Query: 596  ERRVWTMPPMAVALKPVLQQSREAR 620
              R   +   A  L+ + ++++  R
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQR 1954



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)

Query: 13   GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
            GAE++L    E     Q       +L A+    ++  A A AQ             D   
Sbjct: 1237 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1287

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
             EL  +  VG  + L+++ G + + E+E  R ++  +L+  +     T  R   +   G 
Sbjct: 1288 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344

Query: 129  ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
            + R          A L + R  Q+     P + +QA+ E   +               Q 
Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1390

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
            L + ++    + + C+R  +     + + + QL         VA+  KK  +    +  +
Sbjct: 1391 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1450

Query: 240  ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
               V+    H +E T           E LR ++EE + AE  R++++E +  +E +L + 
Sbjct: 1451 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1509

Query: 288  -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
                   A      E+E+  LQQR +E +    +A    ++A+QQ+  + +E        
Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1566

Query: 333  ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
                     + +AA   +L    E+  +R  LE   +     E +L+   +A  EE++AQ
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1625

Query: 384  LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
              + +E+++R   Q   E+Q +         R++ E + AR ++ ALQ LE   +QA   
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
             +R++   +  V+  ++V   L  AQ S+  +  S R    ++   L    Q+E  + +A
Sbjct: 1686 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1741

Query: 502  QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
            Q + E AER  +QQ  AE      ARE+A         ++LE  +++  E L+  LQA  
Sbjct: 1742 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1785

Query: 562  DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
            +E  Q  S               +    +E E+E RR       AV  + + +Q  E + 
Sbjct: 1786 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835

Query: 622  EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
            +L  G      ++  +L  L   + Q +   Q LE
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)

Query: 45   SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
            +RQAEA  R++L +              +E  R + + LE   +++ G++   E++++R 
Sbjct: 1574 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1617

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            + +      R        +     +  +         A+ +            + QALEE
Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
            L  R  +      L   + +  R    +  T ++  E  +QS +    E   QL      
Sbjct: 1678 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735

Query: 220  --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
              VAVA     A+R+  +    E+  +   R +E W   + +  E LR   +  + A+  
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1792

Query: 271  RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
               Q E   + E++  EA      E+++ R ++   + LE++RQ                
Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852

Query: 316  LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            + LR E EQ  Q+  +L+EE     R+AA A Q  + +ELE   A +  E +     + +
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1910

Query: 369  LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
             +E  ++  E+S+ +LE E   + R  + A E     AL +   R+ +  E D AR+  +
Sbjct: 1911 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
            A ++    + A  E+ R++ E+E+A++ ++   ERL +  E    Q        R++L++
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 2019

Query: 488  LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
             + QH+ ++  +LAQ +       ERQ+ + ED   +  + +  +  L++  ++    + 
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079

Query: 548  EL 549
            EL
Sbjct: 2080 EL 2081



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)

Query: 213  ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
            ELQ+  A A  A R++  + E+L            R + E    L+   E    A + R 
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2395

Query: 273  KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            K       QE   +++Q   EA       QE+ARL+Q   E L ++R      L+ + Q 
Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2454

Query: 327  CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
              V +  R  A A  L + +EL   +A  L+E+++  AQQ  +  + +Q  L+ E Q QL
Sbjct: 2455 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513

Query: 385  E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
            E                    R +E +QR  + A E           TQ ++ LVQ+ E+
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
            +R + + D  R      +LE    + + E++ +QL+SE    VQ EQ + E  A  Q+S 
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2632

Query: 471  LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
            L +  SL +  R                    +QL++   + QQ++  +  +    M E 
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692

Query: 511  EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
              RQ +  E       EL+   +Q R  E  L   NQ+L EQ ++L+E       AH +E
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2751

Query: 564  --ANQLLST-TLP 573
              A+Q+ +T TLP
Sbjct: 2752 VTASQVAATKTLP 2764



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)

Query: 215  QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
            Q+QLA   AA R++      L + LA + E    + EAE          E LR L E+  
Sbjct: 1953 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011

Query: 266  AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
                 R + +E   + +  + E +  L +  +S   +Q        R+R  +EEE  AL 
Sbjct: 2012 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
               E               A AG+     EL  +R+  E+  ++  Q E +     Q   
Sbjct: 2069 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2114

Query: 378  EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
            EE + + E E E+ Q+   A  E   Q      EV RL+ +++ ARR R+         L
Sbjct: 2115 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173

Query: 430  QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
            QL     Q R ++         Q+ + E +  +Q EQ V ++L + +  + R+AA   E 
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2232

Query: 481  HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
             R Q +  + Q   Q E A +L Q   E A+   + Q  AE       +E AR       
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2285

Query: 539  NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
              Q E+  +   +   A ++ H   A Q L
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  + K        L     E  +   +A     ++  + E++ K   + V+   R 
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            +AE       LQ++ + A+    + QE   ++ Q L+E  +   R  E+ R +Q E   +
Sbjct: 2463 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2515

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
              E + L LR+ AE  R     EE DA R  + +E    +  R  L  +E+ T  Q    
Sbjct: 2516 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573

Query: 366  EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
            + Q  +H      E+ A+LEREKEK Q+EA+       ++  VQ E  ++  +    +  
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633

Query: 424  RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
             E+D+L Q E  + Q + + +++ Q E   A QL +    +  Q ++   R  AS+ E  
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693

Query: 482  RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            R+Q                L+    Q ++ LA +  + + ++   EE+ +      E   
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753

Query: 526  AREQARVCELQSGNQQLEEQRVE 548
            A + A    L +G   L+    E
Sbjct: 2754 ASQVAATKTLPNGRDALDGPAAE 2776



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)

Query: 311  EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
            +E Q    RLEA+ Q    L  +           +   R  QL     L T R    EE+
Sbjct: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1059

Query: 360  QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
            +   Q  H L+ HYQA   +SQ             ERE        Q   ++  Q A  +
Sbjct: 1060 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1116

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
            S  +R   EL   R     LQLE    +  +   R+ L+ E A +  QR+ E + AQA+ 
Sbjct: 1117 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1170

Query: 469  SSL 471
              L
Sbjct: 1171 EGL 1173


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  104 bits (259), Expect = 4e-22
 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
            R + E  ++S +   LE  +Q  +A   +R++    E++ K+LA   E   + +A   EV
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989

Query: 257  LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
             R   +  +A  L    +QE+  +L+ +   A + L  E+++    +QQ+E+E   TL++
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049

Query: 312  ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E+  L  LR EAE  R          +Q ER+AA++ +  E  E E L+ + EE+ Q  A
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2107

Query: 364  QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
            Q +                + +    AL+++  A  E EK K       +++AQ   E  
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167

Query: 401  --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
                    T HQ  L+  E++RL+ E   A R+R  ++ E+  V+ + E       RI+ 
Sbjct: 2168 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2227

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
            E+   +  ++  T+R  Q +   ++Q A      S+      +L+ L+ +    Q+ LA 
Sbjct: 2228 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287

Query: 499  QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
            ++ + K++  +   R +  AE    +  LA+EQAR   LQ   +Q+ +Q  E  +  Q  
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2345

Query: 557  LQA 559
            L+A
Sbjct: 2346 LEA 2348



 Score =  103 bits (256), Expect = 1e-21
 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
            A+D++  +R   E   Q  Q+   E+Q +   A AA+R +   IE+  + +   +E   R
Sbjct: 1386 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1444

Query: 249  HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
                    L+ L+   + AE  + + QE   RL + +            E    +  E E
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504

Query: 298  SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
            +AR +QR  + LEE      LRL+AE+    + Q E + AR  Q++      +  A L+ 
Sbjct: 1505 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558

Query: 358  ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
            +R ++A++  QL+   ++LQEE  A + + +E+++R AQ   E +      + E+ R + 
Sbjct: 1559 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1613

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
                  +  +AL+L +   +   +    Q E+E   +  +R   R  +A+E ++RQ    
Sbjct: 1614 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668

Query: 478  REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
             +   KQ Q   G  QQ LA+  +L + + E  E+ E+Q+Q+ E+   RL RE A   + 
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1727

Query: 536  QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
            +   Q+LE +  ++   ++ +L +      +  ST              S    Q  E E
Sbjct: 1728 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1770

Query: 596  ERRVWTMPPMAVALKPVLQQSREAR 620
              R   +   A  L+ + ++++  R
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQR 1795



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)

Query: 13   GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
            GAE++L    E     Q       +L A+    ++  A A AQ             D   
Sbjct: 1078 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1128

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
             EL  +  VG  + L+++ G + + E+E  R ++  +L+  +     T  R   +   G 
Sbjct: 1129 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185

Query: 129  ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
            + R          A L + R  Q+     P + +QA+ E   +               Q 
Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1231

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
            L + ++    + + C+R  +     + + + QL         VA+  KK  +    +  +
Sbjct: 1232 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1291

Query: 240  ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
               V+    H +E T           E LR ++EE + AE  R++++E +  +E +L + 
Sbjct: 1292 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1350

Query: 288  -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
                   A      E+E+  LQQR +E +    +A    ++A+QQ+  + +E        
Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1407

Query: 333  ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
                     + +AA   +L    E+  +R  LE   +     E +L+   +A  EE++AQ
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1466

Query: 384  LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
              + +E+++R   Q   E+Q +         R++ E + AR ++ ALQ LE   +QA   
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
             +R++   +  V+  ++V   L  AQ S+  +  S R    ++   L    Q+E  + +A
Sbjct: 1527 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1582

Query: 502  QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
            Q + E AER  +QQ  AE      ARE+A         ++LE  +++  E L+  LQA  
Sbjct: 1583 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1626

Query: 562  DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
            +E  Q  S               +    +E E+E RR       AV  + + +Q  E + 
Sbjct: 1627 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676

Query: 622  EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
            +L  G      ++  +L  L   + Q +   Q LE
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)

Query: 45   SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
            +RQAEA  R++L +              +E  R + + LE   +++ G++   E++++R 
Sbjct: 1415 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1458

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            + +      R        +     +  +         A+ +            + QALEE
Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
            L  R  +      L   + +  R    +  T ++  E  +QS +    E   QL      
Sbjct: 1519 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576

Query: 220  --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
              VAVA     A+R+  +    E+  +   R +E W   + +  E LR   +  + A+  
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1633

Query: 271  RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
               Q E   + E++  EA      E+++ R ++   + LE++RQ                
Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693

Query: 316  LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            + LR E EQ  Q+  +L+EE     R+AA A Q  + +ELE   A +  E +     + +
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1751

Query: 369  LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
             +E  ++  E+S+ +LE E   + R  + A E     AL +   R+ +  E D AR+  +
Sbjct: 1752 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
            A ++    + A  E+ R++ E+E+A++ ++   ERL +  E    Q        R++L++
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1860

Query: 488  LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
             + QH+ ++  +LAQ +       ERQ+ + ED   +  + +  +  L++  ++    + 
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920

Query: 548  EL 549
            EL
Sbjct: 1921 EL 1922



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)

Query: 213  ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
            ELQ+  A A  A R++  + E+L            R + E    L+   E    A + R 
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2236

Query: 273  KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            K       QE   +++Q   EA       QE+ARL+Q   E L ++R      L+ + Q 
Sbjct: 2237 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2295

Query: 327  CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
              V +  R  A A  L + +EL   +A  L+E+++  AQQ  +  + +Q  L+ E Q QL
Sbjct: 2296 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354

Query: 385  E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
            E                    R +E +QR  + A E           TQ ++ LVQ+ E+
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
            +R + + D  R      +LE    + + E++ +QL+SE    VQ EQ + E  A  Q+S 
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2473

Query: 471  LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
            L +  SL +  R                    +QL++   + QQ++  +  +    M E 
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533

Query: 511  EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
              RQ +  E       EL+   +Q R  E  L   NQ+L EQ ++L+E       AH +E
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2592

Query: 564  --ANQLLST-TLP 573
              A+Q+ +T TLP
Sbjct: 2593 VTASQVAATKTLP 2605



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)

Query: 215  QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
            Q+QLA   AA R++      L + LA + E    + EAE          E LR L E+  
Sbjct: 1794 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852

Query: 266  AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
                 R + +E   + +  + E +  L +  +S   +Q        R+R  +EEE  AL 
Sbjct: 1853 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
               E               A AG+     EL  +R+  E+  ++  Q E +     Q   
Sbjct: 1910 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1955

Query: 378  EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
            EE + + E E E+ Q+   A  E   Q      EV RL+ +++ ARR R+         L
Sbjct: 1956 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014

Query: 430  QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
            QL     Q R ++         Q+ + E +  +Q EQ V ++L + +  + R+AA   E 
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2073

Query: 481  HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
             R Q +  + Q   Q E A +L Q   E A+   + Q  AE       +E AR       
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2126

Query: 539  NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
              Q E+  +   +   A ++ H   A Q L
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  + K        L     E  +   +A     ++  + E++ K   + V+   R 
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            +AE       LQ++ + A+    + QE   ++ Q L+E  +   R  E+ R +Q E   +
Sbjct: 2304 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2356

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
              E + L LR+ AE  R     EE DA R  + +E    +  R  L  +E+ T  Q    
Sbjct: 2357 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414

Query: 366  EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
            + Q  +H      E+ A+LEREKEK Q+EA+       ++  VQ E  ++  +    +  
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474

Query: 424  RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
             E+D+L Q E  + Q + + +++ Q E   A QL +    +  Q ++   R  AS+ E  
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534

Query: 482  RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            R+Q                L+    Q ++ LA +  + + ++   EE+ +      E   
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594

Query: 526  AREQARVCELQSGNQQLEEQRVE 548
            A + A    L +G   L+    E
Sbjct: 2595 ASQVAATKTLPNGRDALDGPAAE 2617



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)

Query: 311  EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
            +E Q    RLEA+ Q    L  +           +   R  QL     L T R    EE+
Sbjct: 841  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900

Query: 360  QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
            +   Q  H L+ HYQA   +SQ             ERE        Q   ++  Q A  +
Sbjct: 901  R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 957

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
            S  +R   EL   R     LQLE    +  +   R+ L+ E A +  QR+ E + AQA+ 
Sbjct: 958  SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1011

Query: 469  SSL 471
              L
Sbjct: 1012 EGL 1014


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  104 bits (259), Expect = 4e-22
 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
            R + E  ++S +   LE  +Q  +A   +R++    E++ K+LA   E   + +A   EV
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997

Query: 257  LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
             R   +  +A  L    +QE+  +L+ +   A + L  E+++    +QQ+E+E   TL++
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057

Query: 312  ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E+  L  LR EAE  R          +Q ER+AA++ +  E  E E L+ + EE+ Q  A
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2115

Query: 364  QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
            Q +                + +    AL+++  A  E EK K       +++AQ   E  
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175

Query: 401  --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
                    T HQ  L+  E++RL+ E   A R+R  ++ E+  V+ + E       RI+ 
Sbjct: 2176 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2235

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
            E+   +  ++  T+R  Q +   ++Q A      S+      +L+ L+ +    Q+ LA 
Sbjct: 2236 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295

Query: 499  QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
            ++ + K++  +   R +  AE    +  LA+EQAR   LQ   +Q+ +Q  E  +  Q  
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2353

Query: 557  LQA 559
            L+A
Sbjct: 2354 LEA 2356



 Score =  103 bits (256), Expect = 1e-21
 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
            A+D++  +R   E   Q  Q+   E+Q +   A AA+R +   IE+  + +   +E   R
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1452

Query: 249  HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
                    L+ L+   + AE  + + QE   RL + +            E    +  E E
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512

Query: 298  SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
            +AR +QR  + LEE      LRL+AE+    + Q E + AR  Q++      +  A L+ 
Sbjct: 1513 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566

Query: 358  ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
            +R ++A++  QL+   ++LQEE  A + + +E+++R AQ   E +      + E+ R + 
Sbjct: 1567 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1621

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
                  +  +AL+L +   +   +    Q E+E   +  +R   R  +A+E ++RQ    
Sbjct: 1622 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1676

Query: 478  REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
             +   KQ Q   G  QQ LA+  +L + + E  E+ E+Q+Q+ E+   RL RE A   + 
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1735

Query: 536  QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
            +   Q+LE +  ++   ++ +L +      +  ST              S    Q  E E
Sbjct: 1736 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1778

Query: 596  ERRVWTMPPMAVALKPVLQQSREAR 620
              R   +   A  L+ + ++++  R
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQR 1803



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)

Query: 13   GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
            GAE++L    E     Q       +L A+    ++  A A AQ             D   
Sbjct: 1086 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1136

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
             EL  +  VG  + L+++ G + + E+E  R ++  +L+  +     T  R   +   G 
Sbjct: 1137 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193

Query: 129  ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
            + R          A L + R  Q+     P + +QA+ E   +               Q 
Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1239

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
            L + ++    + + C+R  +     + + + QL         VA+  KK  +    +  +
Sbjct: 1240 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1299

Query: 240  ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
               V+    H +E T           E LR ++EE + AE  R++++E +  +E +L + 
Sbjct: 1300 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1358

Query: 288  -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
                   A      E+E+  LQQR +E +    +A    ++A+QQ+  + +E        
Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1415

Query: 333  ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
                     + +AA   +L    E+  +R  LE   +     E +L+   +A  EE++AQ
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1474

Query: 384  LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
              + +E+++R   Q   E+Q +         R++ E + AR ++ ALQ LE   +QA   
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
             +R++   +  V+  ++V   L  AQ S+  +  S R    ++   L    Q+E  + +A
Sbjct: 1535 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1590

Query: 502  QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
            Q + E AER  +QQ  AE      ARE+A         ++LE  +++  E L+  LQA  
Sbjct: 1591 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1634

Query: 562  DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
            +E  Q  S               +    +E E+E RR       AV  + + +Q  E + 
Sbjct: 1635 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684

Query: 622  EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
            +L  G      ++  +L  L   + Q +   Q LE
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)

Query: 45   SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
            +RQAEA  R++L +              +E  R + + LE   +++ G++   E++++R 
Sbjct: 1423 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1466

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            + +      R        +     +  +         A+ +            + QALEE
Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
            L  R  +      L   + +  R    +  T ++  E  +QS +    E   QL      
Sbjct: 1527 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584

Query: 220  --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
              VAVA     A+R+  +    E+  +   R +E W   + +  E LR   +  + A+  
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1641

Query: 271  RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
               Q E   + E++  EA      E+++ R ++   + LE++RQ                
Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701

Query: 316  LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            + LR E EQ  Q+  +L+EE     R+AA A Q  + +ELE   A +  E +     + +
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1759

Query: 369  LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
             +E  ++  E+S+ +LE E   + R  + A E     AL +   R+ +  E D AR+  +
Sbjct: 1760 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
            A ++    + A  E+ R++ E+E+A++ ++   ERL +  E    Q        R++L++
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1868

Query: 488  LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
             + QH+ ++  +LAQ +       ERQ+ + ED   +  + +  +  L++  ++    + 
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928

Query: 548  EL 549
            EL
Sbjct: 1929 EL 1930



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)

Query: 213  ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
            ELQ+  A A  A R++  + E+L            R + E    L+   E    A + R 
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2244

Query: 273  KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            K       QE   +++Q   EA       QE+ARL+Q   E L ++R      L+ + Q 
Sbjct: 2245 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2303

Query: 327  CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
              V +  R  A A  L + +EL   +A  L+E+++  AQQ  +  + +Q  L+ E Q QL
Sbjct: 2304 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362

Query: 385  E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
            E                    R +E +QR  + A E           TQ ++ LVQ+ E+
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
            +R + + D  R      +LE    + + E++ +QL+SE    VQ EQ + E  A  Q+S 
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2481

Query: 471  LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
            L +  SL +  R                    +QL++   + QQ++  +  +    M E 
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541

Query: 511  EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
              RQ +  E       EL+   +Q R  E  L   NQ+L EQ ++L+E       AH +E
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2600

Query: 564  --ANQLLST-TLP 573
              A+Q+ +T TLP
Sbjct: 2601 VTASQVAATKTLP 2613



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)

Query: 215  QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
            Q+QLA   AA R++      L + LA + E    + EAE          E LR L E+  
Sbjct: 1802 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860

Query: 266  AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
                 R + +E   + +  + E +  L +  +S   +Q        R+R  +EEE  AL 
Sbjct: 1861 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
               E               A AG+     EL  +R+  E+  ++  Q E +     Q   
Sbjct: 1918 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1963

Query: 378  EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
            EE + + E E E+ Q+   A  E   Q      EV RL+ +++ ARR R+         L
Sbjct: 1964 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022

Query: 430  QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
            QL     Q R ++         Q+ + E +  +Q EQ V ++L + +  + R+AA   E 
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2081

Query: 481  HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
             R Q +  + Q   Q E A +L Q   E A+   + Q  AE       +E AR       
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2134

Query: 539  NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
              Q E+  +   +   A ++ H   A Q L
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  + K        L     E  +   +A     ++  + E++ K   + V+   R 
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            +AE       LQ++ + A+    + QE   ++ Q L+E  +   R  E+ R +Q E   +
Sbjct: 2312 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2364

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
              E + L LR+ AE  R     EE DA R  + +E    +  R  L  +E+ T  Q    
Sbjct: 2365 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422

Query: 366  EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
            + Q  +H      E+ A+LEREKEK Q+EA+       ++  VQ E  ++  +    +  
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482

Query: 424  RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
             E+D+L Q E  + Q + + +++ Q E   A QL +    +  Q ++   R  AS+ E  
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542

Query: 482  RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            R+Q                L+    Q ++ LA +  + + ++   EE+ +      E   
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602

Query: 526  AREQARVCELQSGNQQLEEQRVE 548
            A + A    L +G   L+    E
Sbjct: 2603 ASQVAATKTLPNGRDALDGPAAE 2625



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)

Query: 311  EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
            +E Q    RLEA+ Q    L  +           +   R  QL     L T R    EE+
Sbjct: 849  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 908

Query: 360  QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
            +   Q  H L+ HYQA   +SQ             ERE        Q   ++  Q A  +
Sbjct: 909  R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 965

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
            S  +R   EL   R     LQLE    +  +   R+ L+ E A +  QR+ E + AQA+ 
Sbjct: 966  SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1019

Query: 469  SSL 471
              L
Sbjct: 1020 EGL 1022


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  104 bits (259), Expect = 4e-22
 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
            R + E  ++S +   LE  +Q  +A   +R++    E++ K+LA   E   + +A   EV
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038

Query: 257  LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
             R   +  +A  L    +QE+  +L+ +   A + L  E+++    +QQ+E+E   TL++
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098

Query: 312  ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E+  L  LR EAE  R          +Q ER+AA++ +  E  E E L+ + EE+ Q  A
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2156

Query: 364  QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
            Q +                + +    AL+++  A  E EK K       +++AQ   E  
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216

Query: 401  --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
                    T HQ  L+  E++RL+ E   A R+R  ++ E+  V+ + E       RI+ 
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2276

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
            E+   +  ++  T+R  Q +   ++Q A      S+      +L+ L+ +    Q+ LA 
Sbjct: 2277 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336

Query: 499  QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
            ++ + K++  +   R +  AE    +  LA+EQAR   LQ   +Q+ +Q  E  +  Q  
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2394

Query: 557  LQA 559
            L+A
Sbjct: 2395 LEA 2397



 Score =  103 bits (256), Expect = 1e-21
 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)

Query: 189  ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
            A+D++  +R   E   Q  Q+   E+Q +   A AA+R +   IE+  + +   +E   R
Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1493

Query: 249  HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
                    L+ L+   + AE  + + QE   RL + +            E    +  E E
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553

Query: 298  SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
            +AR +QR  + LEE      LRL+AE+    + Q E + AR  Q++      +  A L+ 
Sbjct: 1554 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607

Query: 358  ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
            +R ++A++  QL+   ++LQEE  A + + +E+++R AQ   E +      + E+ R + 
Sbjct: 1608 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1662

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
                  +  +AL+L +   +   +    Q E+E   +  +R   R  +A+E ++RQ    
Sbjct: 1663 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1717

Query: 478  REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
             +   KQ Q   G  QQ LA+  +L + + E  E+ E+Q+Q+ E+   RL RE A   + 
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1776

Query: 536  QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
            +   Q+LE +  ++   ++ +L +      +  ST              S    Q  E E
Sbjct: 1777 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1819

Query: 596  ERRVWTMPPMAVALKPVLQQSREAR 620
              R   +   A  L+ + ++++  R
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQR 1844



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)

Query: 13   GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
            GAE++L    E     Q       +L A+    ++  A A AQ             D   
Sbjct: 1127 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1177

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
             EL  +  VG  + L+++ G + + E+E  R ++  +L+  +     T  R   +   G 
Sbjct: 1178 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234

Query: 129  ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
            + R          A L + R  Q+     P + +QA+ E   +               Q 
Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1280

Query: 186  LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
            L + ++    + + C+R  +     + + + QL         VA+  KK  +    +  +
Sbjct: 1281 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1340

Query: 240  ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
               V+    H +E T           E LR ++EE + AE  R++++E +  +E +L + 
Sbjct: 1341 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1399

Query: 288  -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
                   A      E+E+  LQQR +E +    +A    ++A+QQ+  + +E        
Sbjct: 1400 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1456

Query: 333  ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
                     + +AA   +L    E+  +R  LE   +     E +L+   +A  EE++AQ
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1515

Query: 384  LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
              + +E+++R   Q   E+Q +         R++ E + AR ++ ALQ LE   +QA   
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
             +R++   +  V+  ++V   L  AQ S+  +  S R    ++   L    Q+E  + +A
Sbjct: 1576 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1631

Query: 502  QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
            Q + E AER  +QQ  AE      ARE+A         ++LE  +++  E L+  LQA  
Sbjct: 1632 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1675

Query: 562  DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
            +E  Q  S               +    +E E+E RR       AV  + + +Q  E + 
Sbjct: 1676 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725

Query: 622  EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
            +L  G      ++  +L  L   + Q +   Q LE
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)

Query: 45   SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
            +RQAEA  R++L +              +E  R + + LE   +++ G++   E++++R 
Sbjct: 1464 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1507

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            + +      R        +     +  +         A+ +            + QALEE
Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
            L  R  +      L   + +  R    +  T ++  E  +QS +    E   QL      
Sbjct: 1568 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625

Query: 220  --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
              VAVA     A+R+  +    E+  +   R +E W   + +  E LR   +  + A+  
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1682

Query: 271  RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
               Q E   + E++  EA      E+++ R ++   + LE++RQ                
Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742

Query: 316  LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
            + LR E EQ  Q+  +L+EE     R+AA A Q  + +ELE   A +  E +     + +
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1800

Query: 369  LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
             +E  ++  E+S+ +LE E   + R  + A E     AL +   R+ +  E D AR+  +
Sbjct: 1801 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
            A ++    + A  E+ R++ E+E+A++ ++   ERL +  E    Q        R++L++
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1909

Query: 488  LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
             + QH+ ++  +LAQ +       ERQ+ + ED   +  + +  +  L++  ++    + 
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969

Query: 548  EL 549
            EL
Sbjct: 1970 EL 1971



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)

Query: 213  ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
            ELQ+  A A  A R++  + E+L            R + E    L+   E    A + R 
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2285

Query: 273  KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            K       QE   +++Q   EA       QE+ARL+Q   E L ++R      L+ + Q 
Sbjct: 2286 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2344

Query: 327  CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
              V +  R  A A  L + +EL   +A  L+E+++  AQQ  +  + +Q  L+ E Q QL
Sbjct: 2345 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403

Query: 385  E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
            E                    R +E +QR  + A E           TQ ++ LVQ+ E+
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463

Query: 413  RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
            +R + + D  R      +LE    + + E++ +QL+SE    VQ EQ + E  A  Q+S 
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2522

Query: 471  LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
            L +  SL +  R                    +QL++   + QQ++  +  +    M E 
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582

Query: 511  EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
              RQ +  E       EL+   +Q R  E  L   NQ+L EQ ++L+E       AH +E
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2641

Query: 564  --ANQLLST-TLP 573
              A+Q+ +T TLP
Sbjct: 2642 VTASQVAATKTLP 2654



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)

Query: 215  QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
            Q+QLA   AA R++      L + LA + E    + EAE          E LR L E+  
Sbjct: 1843 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901

Query: 266  AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
                 R + +E   + +  + E +  L +  +S   +Q        R+R  +EEE  AL 
Sbjct: 1902 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
               E               A AG+     EL  +R+  E+  ++  Q E +     Q   
Sbjct: 1959 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2004

Query: 378  EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
            EE + + E E E+ Q+   A  E   Q      EV RL+ +++ ARR R+         L
Sbjct: 2005 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063

Query: 430  QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
            QL     Q R ++         Q+ + E +  +Q EQ V ++L + +  + R+AA   E 
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2122

Query: 481  HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
             R Q +  + Q   Q E A +L Q   E A+   + Q  AE       +E AR       
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2175

Query: 539  NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
              Q E+  +   +   A ++ H   A Q L
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L  E  + K        L     E  +   +A     ++  + E++ K   + V+   R 
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            +AE       LQ++ + A+    + QE   ++ Q L+E  +   R  E+ R +Q E   +
Sbjct: 2353 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2405

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
              E + L LR+ AE  R     EE DA R  + +E    +  R  L  +E+ T  Q    
Sbjct: 2406 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463

Query: 366  EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
            + Q  +H      E+ A+LEREKEK Q+EA+       ++  VQ E  ++  +    +  
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523

Query: 424  RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
             E+D+L Q E  + Q + + +++ Q E   A QL +    +  Q ++   R  AS+ E  
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583

Query: 482  RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            R+Q                L+    Q ++ LA +  + + ++   EE+ +      E   
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2643

Query: 526  AREQARVCELQSGNQQLEEQRVE 548
            A + A    L +G   L+    E
Sbjct: 2644 ASQVAATKTLPNGRDALDGPAAE 2666



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)

Query: 311  EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
            +E Q    RLEA+ Q    L  +           +   R  QL     L T R    EE+
Sbjct: 890  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 949

Query: 360  QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
            +   Q  H L+ HYQA   +SQ             ERE        Q   ++  Q A  +
Sbjct: 950  R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1006

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
            S  +R   EL   R     LQLE    +  +   R+ L+ E A +  QR+ E + AQA+ 
Sbjct: 1007 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1060

Query: 469  SSL 471
              L
Sbjct: 1061 EGL 1063


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%)

Query: 27   LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82
            L +  + +  QL A   L  +AE T    A  +  L       E   G  +E SR +   
Sbjct: 910  LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 968

Query: 83   LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141
                 +KK   +HI E+E+    L+   + +R     + +   A  ++ EED     D  
Sbjct: 969  -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1019

Query: 142  ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
            + L   R L +D     S+QA EE   +  SL             + D L  E   R+  
Sbjct: 1020 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1078

Query: 201  ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257
            E+  + L     ELQ+Q+   V   ++ + +  QL +    +     R E E   R ++L
Sbjct: 1079 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1135

Query: 258  RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307
            + L+E   A AE     + E V R +     + L E +EAL  E E    S   QQ  R 
Sbjct: 1136 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1195

Query: 308  TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363
              E+E   L   LE E +     +QE  +R     G+L+E  E     + A E+ R    
Sbjct: 1196 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1255

Query: 364  QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413
             +  +L+    +LQ      E+ + +LE + ++ Q  A    +A  E   +L   Q+E+ 
Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1315

Query: 414  RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473
             + G L+ A  +   L  E+S  +A+    +  L+ E   +L      R  +A+ + LR+
Sbjct: 1316 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1375

Query: 474  A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523
                 A+ RE   ++LQ    Q       Q+E A  L   +    E   R  + AE    
Sbjct: 1376 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1431

Query: 524  RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577
            RLA +   V  L+ G ++L+++       +E   +L + L+    + +QLL         
Sbjct: 1432 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1482

Query: 578  PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623
             A          +E E+ E         A++L   L++ +EAR+EL
Sbjct: 1483 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1527



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%)

Query: 6    DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65
            D  SS L  E ++        L         +L A+L  +   E  ARAQL L S     
Sbjct: 1086 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1142

Query: 66   EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124
              L    ++L        +   +++D  +   E+E++RG+L+ T+  T+     R     
Sbjct: 1143 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1195

Query: 125  GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178
                 +RE++  +   T    T ++   +Q+L      QAL EL  +    R G      
Sbjct: 1196 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1249

Query: 179  ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234
                   +   LR  L S  T R+  E+  + L+ ++ E+Q +      A  +    +++
Sbjct: 1250 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1309

Query: 235  LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277
                L  V    N  E++   + + L       H A EL    TR+K          +  
Sbjct: 1310 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1369

Query: 278  VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323
               L + L E   A E   RE ++A+ Q  E            E  EE R+      EA 
Sbjct: 1370 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1429

Query: 324  QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
             QR     E  D    G+    +EL+     LE++RQ  +  E + ++  Q L EE  A 
Sbjct: 1430 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1489

Query: 384  LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436
            L   +E+ + EA+        L+L ++     E   +  R+ R AL+ E+  +       
Sbjct: 1490 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1548

Query: 437  -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486
             ++ +E +R  ++  + A  L  +VTE    L  A+++ LR      +L+  H + LQ  
Sbjct: 1549 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1608

Query: 487  -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
             +   + +++LA QL   +VE   ER++R   VA   +L    E+ +     +G  Q +E
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1666

Query: 545  QRVELVERLQAMLQAHWDEANQ 566
            + V+ + ++QA ++  W E  +
Sbjct: 1667 EAVKQLRKMQAQMKELWREVEE 1688



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%)

Query: 185  GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241
            GLR+ L+ E   R+   R +Q+ Q ++ E    Q++ A A+ A        E+  +  AR
Sbjct: 1372 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1424

Query: 242  VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286
              E   +  AE+TE +       R LQ+E   A +   +Q++ V+ LE+           
Sbjct: 1425 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484

Query: 287  ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322
                        E  EA  RE+E+  L        +Q  RE LE + +AL   LEA    
Sbjct: 1485 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1544

Query: 323  ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360
                     E +R C + E+       Q++E  +           LE    AL  + ER 
Sbjct: 1545 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1604

Query: 361  TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397
               + E   +   Q  ++   A++ER++E+ QR                         Q 
Sbjct: 1605 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1664

Query: 398  AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453
              E   QL  +Q++++ L  E++  R  R+ +  +    + R    E++ ++L+ ELA  
Sbjct: 1665 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1724

Query: 454  -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508
                 Q +Q   E   +    +L +AA L E  ++QL+   GQ ++EL  + +  ++ + 
Sbjct: 1725 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1781

Query: 509  EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553
            +R  +     E     L+ E++   + +SG QQLE Q  EL  RL
Sbjct: 1782 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%)

Query: 129  ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
            ER E +  + ++ A  L TR L++       +A EEL  +  +LR        + + L  
Sbjct: 1497 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1543

Query: 189  ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            + D    S H   + C   E+    L+ +V EL+ +L  A  A  + +  ++ L     R
Sbjct: 1544 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1603

Query: 242  VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300
             ++G +    ER    R L ++ + AE+ R ++     R +++L+  A + L  E E  +
Sbjct: 1604 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1655

Query: 301  LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
             Q       +EE      +++A+ +      EE   +R    S++RE E     LE E  
Sbjct: 1656 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1713

Query: 361  TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417
                           LQEE  A     ++  Q   + A E  +     A +  E R+LEG
Sbjct: 1714 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1761

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
             L     E +  Q    L+  RY         +L +Q+E   TE    A+ S   +A S 
Sbjct: 1762 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1811

Query: 478  REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522
            R+   +Q+Q+L G+  +E A   A+ K+ +A  E +  Q  E  E
Sbjct: 1812 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1856



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%)

Query: 182  DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            D QG RD    E  RR+   + ++  +    E ++Q  +AVAA +K +  +E+L   +A 
Sbjct: 1604 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1660

Query: 242  VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294
              +G         + +A+  E+ R ++E   + E   S+ +E+  RL+   +E +    R
Sbjct: 1661 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1716

Query: 295  EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352
             QE      R R   +++R  +   +      +  +L+E+R    R GQL E  E E   
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1776

Query: 353  AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400
            + L  +  R+   Q E    E      + A  E  + QLER+ ++      + +A A   
Sbjct: 1777 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1836

Query: 401  TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460
             +  +A ++S++ + E +L+   RER      +S    R   +R++ E  L V+ E+RV 
Sbjct: 1837 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1890

Query: 461  ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520
            ++L    E    +   L    ++QL++      +E AS+    +  +    E   + AE 
Sbjct: 1891 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1941

Query: 521  YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579
                +   + R   L+ G      + V  V RL+  + A  +EA +    + P P P  +
Sbjct: 1942 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 1997

Query: 580  PPAGP 584
            PPA P
Sbjct: 1998 PPAHP 2002



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%)

Query: 253  RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312
            R + L+ +QE  Q +     + Q  V +LE+  +   E L  E E     +  R  L   
Sbjct: 882  RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 941

Query: 313  RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369
            +Q L L +   + R   + EE + +R  Q  + R    ++ L A LE E    A+Q+ QL
Sbjct: 942  KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 996

Query: 370  K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425
            +    E      EE    LE +  K  +E +   +   + +   +E       L+  R +
Sbjct: 997  EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1056

Query: 426  RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485
             +A   +M     + E  R +LE     +L++R+    ++ QE  + Q     +   ++L
Sbjct: 1057 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1106

Query: 486  QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545
            +   G+ ++EL + LA+ + E   R +  + + E  +  LA  Q  +   +    + E+Q
Sbjct: 1107 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1165

Query: 546  RVELVERLQAM 556
            R +L E L+A+
Sbjct: 1166 RRDLGEELEAL 1176


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%)

Query: 27   LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82
            L +  + +  QL A   L  +AE T    A  +  L       E   G  +E SR +   
Sbjct: 902  LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 960

Query: 83   LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141
                 +KK   +HI E+E+    L+   + +R     + +   A  ++ EED     D  
Sbjct: 961  -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1011

Query: 142  ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
            + L   R L +D     S+QA EE   +  SL             + D L  E   R+  
Sbjct: 1012 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1070

Query: 201  ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257
            E+  + L     ELQ+Q+   V   ++ + +  QL +    +     R E E   R ++L
Sbjct: 1071 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1127

Query: 258  RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307
            + L+E   A AE     + E V R +     + L E +EAL  E E    S   QQ  R 
Sbjct: 1128 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1187

Query: 308  TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363
              E+E   L   LE E +     +QE  +R     G+L+E  E     + A E+ R    
Sbjct: 1188 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1247

Query: 364  QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413
             +  +L+    +LQ      E+ + +LE + ++ Q  A    +A  E   +L   Q+E+ 
Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1307

Query: 414  RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473
             + G L+ A  +   L  E+S  +A+    +  L+ E   +L      R  +A+ + LR+
Sbjct: 1308 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1367

Query: 474  A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523
                 A+ RE   ++LQ    Q       Q+E A  L   +    E   R  + AE    
Sbjct: 1368 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1423

Query: 524  RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577
            RLA +   V  L+ G ++L+++       +E   +L + L+    + +QLL         
Sbjct: 1424 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1474

Query: 578  PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623
             A          +E E+ E         A++L   L++ +EAR+EL
Sbjct: 1475 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1519



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%)

Query: 6    DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65
            D  SS L  E ++        L         +L A+L  +   E  ARAQL L S     
Sbjct: 1078 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1134

Query: 66   EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124
              L    ++L        +   +++D  +   E+E++RG+L+ T+  T+     R     
Sbjct: 1135 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1187

Query: 125  GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178
                 +RE++  +   T    T ++   +Q+L      QAL EL  +    R G      
Sbjct: 1188 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1241

Query: 179  ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234
                   +   LR  L S  T R+  E+  + L+ ++ E+Q +      A  +    +++
Sbjct: 1242 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1301

Query: 235  LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277
                L  V    N  E++   + + L       H A EL    TR+K          +  
Sbjct: 1302 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1361

Query: 278  VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323
               L + L E   A E   RE ++A+ Q  E            E  EE R+      EA 
Sbjct: 1362 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1421

Query: 324  QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
             QR     E  D    G+    +EL+     LE++RQ  +  E + ++  Q L EE  A 
Sbjct: 1422 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1481

Query: 384  LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436
            L   +E+ + EA+        L+L ++     E   +  R+ R AL+ E+  +       
Sbjct: 1482 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1540

Query: 437  -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486
             ++ +E +R  ++  + A  L  +VTE    L  A+++ LR      +L+  H + LQ  
Sbjct: 1541 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1600

Query: 487  -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
             +   + +++LA QL   +VE   ER++R   VA   +L    E+ +     +G  Q +E
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1658

Query: 545  QRVELVERLQAMLQAHWDEANQ 566
            + V+ + ++QA ++  W E  +
Sbjct: 1659 EAVKQLRKMQAQMKELWREVEE 1680



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%)

Query: 185  GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241
            GLR+ L+ E   R+   R +Q+ Q ++ E    Q++ A A+ A        E+  +  AR
Sbjct: 1364 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1416

Query: 242  VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286
              E   +  AE+TE +       R LQ+E   A +   +Q++ V+ LE+           
Sbjct: 1417 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476

Query: 287  ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322
                        E  EA  RE+E+  L        +Q  RE LE + +AL   LEA    
Sbjct: 1477 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1536

Query: 323  ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360
                     E +R C + E+       Q++E  +           LE    AL  + ER 
Sbjct: 1537 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1596

Query: 361  TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397
               + E   +   Q  ++   A++ER++E+ QR                         Q 
Sbjct: 1597 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1656

Query: 398  AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453
              E   QL  +Q++++ L  E++  R  R+ +  +    + R    E++ ++L+ ELA  
Sbjct: 1657 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1716

Query: 454  -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508
                 Q +Q   E   +    +L +AA L E  ++QL+   GQ ++EL  + +  ++ + 
Sbjct: 1717 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1773

Query: 509  EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553
            +R  +     E     L+ E++   + +SG QQLE Q  EL  RL
Sbjct: 1774 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%)

Query: 129  ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
            ER E +  + ++ A  L TR L++       +A EEL  +  +LR        + + L  
Sbjct: 1489 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1535

Query: 189  ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            + D    S H   + C   E+    L+ +V EL+ +L  A  A  + +  ++ L     R
Sbjct: 1536 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1595

Query: 242  VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300
             ++G +    ER    R L ++ + AE+ R ++     R +++L+  A + L  E E  +
Sbjct: 1596 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1647

Query: 301  LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
             Q       +EE      +++A+ +      EE   +R    S++RE E     LE E  
Sbjct: 1648 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1705

Query: 361  TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417
                           LQEE  A     ++  Q   + A E  +     A +  E R+LEG
Sbjct: 1706 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1753

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
             L     E +  Q    L+  RY         +L +Q+E   TE    A+ S   +A S 
Sbjct: 1754 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1803

Query: 478  REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522
            R+   +Q+Q+L G+  +E A   A+ K+ +A  E +  Q  E  E
Sbjct: 1804 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1848



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%)

Query: 182  DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            D QG RD    E  RR+   + ++  +    E ++Q  +AVAA +K +  +E+L   +A 
Sbjct: 1596 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1652

Query: 242  VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294
              +G         + +A+  E+ R ++E   + E   S+ +E+  RL+   +E +    R
Sbjct: 1653 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1708

Query: 295  EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352
             QE      R R   +++R  +   +      +  +L+E+R    R GQL E  E E   
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1768

Query: 353  AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400
            + L  +  R+   Q E    E      + A  E  + QLER+ ++      + +A A   
Sbjct: 1769 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1828

Query: 401  TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460
             +  +A ++S++ + E +L+   RER      +S    R   +R++ E  L V+ E+RV 
Sbjct: 1829 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1882

Query: 461  ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520
            ++L    E    +   L    ++QL++      +E AS+    +  +    E   + AE 
Sbjct: 1883 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1933

Query: 521  YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579
                +   + R   L+ G      + V  V RL+  + A  +EA +    + P P P  +
Sbjct: 1934 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 1989

Query: 580  PPAGP 584
            PPA P
Sbjct: 1990 PPAHP 1994



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%)

Query: 253  RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312
            R + L+ +QE  Q +     + Q  V +LE+  +   E L  E E     +  R  L   
Sbjct: 874  RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 933

Query: 313  RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369
            +Q L L +   + R   + EE + +R  Q  + R    ++ L A LE E    A+Q+ QL
Sbjct: 934  KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 988

Query: 370  K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425
            +    E      EE    LE +  K  +E +   +   + +   +E       L+  R +
Sbjct: 989  EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1048

Query: 426  RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485
             +A   +M     + E  R +LE     +L++R+    ++ QE  + Q     +   ++L
Sbjct: 1049 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1098

Query: 486  QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545
            +   G+ ++EL + LA+ + E   R +  + + E  +  LA  Q  +   +    + E+Q
Sbjct: 1099 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1157

Query: 546  RVELVERLQAM 556
            R +L E L+A+
Sbjct: 1158 RRDLGEELEAL 1168


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%)

Query: 27   LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82
            L +  + +  QL A   L  +AE T    A  +  L       E   G  +E SR +   
Sbjct: 943  LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 1001

Query: 83   LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141
                 +KK   +HI E+E+    L+   + +R     + +   A  ++ EED     D  
Sbjct: 1002 -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1052

Query: 142  ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
            + L   R L +D     S+QA EE   +  SL             + D L  E   R+  
Sbjct: 1053 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1111

Query: 201  ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257
            E+  + L     ELQ+Q+   V   ++ + +  QL +    +     R E E   R ++L
Sbjct: 1112 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1168

Query: 258  RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307
            + L+E   A AE     + E V R +     + L E +EAL  E E    S   QQ  R 
Sbjct: 1169 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1228

Query: 308  TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363
              E+E   L   LE E +     +QE  +R     G+L+E  E     + A E+ R    
Sbjct: 1229 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1288

Query: 364  QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413
             +  +L+    +LQ      E+ + +LE + ++ Q  A    +A  E   +L   Q+E+ 
Sbjct: 1289 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1348

Query: 414  RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473
             + G L+ A  +   L  E+S  +A+    +  L+ E   +L      R  +A+ + LR+
Sbjct: 1349 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1408

Query: 474  A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523
                 A+ RE   ++LQ    Q       Q+E A  L   +    E   R  + AE    
Sbjct: 1409 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1464

Query: 524  RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577
            RLA +   V  L+ G ++L+++       +E   +L + L+    + +QLL         
Sbjct: 1465 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1515

Query: 578  PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623
             A          +E E+ E         A++L   L++ +EAR+EL
Sbjct: 1516 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1560



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%)

Query: 6    DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65
            D  SS L  E ++        L         +L A+L  +   E  ARAQL L S     
Sbjct: 1119 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1175

Query: 66   EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124
              L    ++L        +   +++D  +   E+E++RG+L+ T+  T+     R     
Sbjct: 1176 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1228

Query: 125  GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178
                 +RE++  +   T    T ++   +Q+L      QAL EL  +    R G      
Sbjct: 1229 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1282

Query: 179  ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234
                   +   LR  L S  T R+  E+  + L+ ++ E+Q +      A  +    +++
Sbjct: 1283 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1342

Query: 235  LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277
                L  V    N  E++   + + L       H A EL    TR+K          +  
Sbjct: 1343 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1402

Query: 278  VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323
               L + L E   A E   RE ++A+ Q  E            E  EE R+      EA 
Sbjct: 1403 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1462

Query: 324  QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
             QR     E  D    G+    +EL+     LE++RQ  +  E + ++  Q L EE  A 
Sbjct: 1463 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1522

Query: 384  LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436
            L   +E+ + EA+        L+L ++     E   +  R+ R AL+ E+  +       
Sbjct: 1523 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1581

Query: 437  -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486
             ++ +E +R  ++  + A  L  +VTE    L  A+++ LR      +L+  H + LQ  
Sbjct: 1582 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1641

Query: 487  -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
             +   + +++LA QL   +VE   ER++R   VA   +L    E+ +     +G  Q +E
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1699

Query: 545  QRVELVERLQAMLQAHWDEANQ 566
            + V+ + ++QA ++  W E  +
Sbjct: 1700 EAVKQLRKMQAQMKELWREVEE 1721



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%)

Query: 185  GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241
            GLR+ L+ E   R+   R +Q+ Q ++ E    Q++ A A+ A        E+  +  AR
Sbjct: 1405 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1457

Query: 242  VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286
              E   +  AE+TE +       R LQ+E   A +   +Q++ V+ LE+           
Sbjct: 1458 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1517

Query: 287  ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322
                        E  EA  RE+E+  L        +Q  RE LE + +AL   LEA    
Sbjct: 1518 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1577

Query: 323  ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360
                     E +R C + E+       Q++E  +           LE    AL  + ER 
Sbjct: 1578 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1637

Query: 361  TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397
               + E   +   Q  ++   A++ER++E+ QR                         Q 
Sbjct: 1638 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1697

Query: 398  AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453
              E   QL  +Q++++ L  E++  R  R+ +  +    + R    E++ ++L+ ELA  
Sbjct: 1698 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1757

Query: 454  -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508
                 Q +Q   E   +    +L +AA L E  ++QL+   GQ ++EL  + +  ++ + 
Sbjct: 1758 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1814

Query: 509  EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553
            +R  +     E     L+ E++   + +SG QQLE Q  EL  RL
Sbjct: 1815 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%)

Query: 129  ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
            ER E +  + ++ A  L TR L++       +A EEL  +  +LR        + + L  
Sbjct: 1530 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1576

Query: 189  ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            + D    S H   + C   E+    L+ +V EL+ +L  A  A  + +  ++ L     R
Sbjct: 1577 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1636

Query: 242  VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300
             ++G +    ER    R L ++ + AE+ R ++     R +++L+  A + L  E E  +
Sbjct: 1637 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1688

Query: 301  LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
             Q       +EE      +++A+ +      EE   +R    S++RE E     LE E  
Sbjct: 1689 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1746

Query: 361  TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417
                           LQEE  A     ++  Q   + A E  +     A +  E R+LEG
Sbjct: 1747 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1794

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
             L     E +  Q    L+  RY         +L +Q+E   TE    A+ S   +A S 
Sbjct: 1795 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1844

Query: 478  REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522
            R+   +Q+Q+L G+  +E A   A+ K+ +A  E +  Q  E  E
Sbjct: 1845 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1889



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%)

Query: 182  DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            D QG RD    E  RR+   + ++  +    E ++Q  +AVAA +K +  +E+L   +A 
Sbjct: 1637 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1693

Query: 242  VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294
              +G         + +A+  E+ R ++E   + E   S+ +E+  RL+   +E +    R
Sbjct: 1694 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1749

Query: 295  EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352
             QE      R R   +++R  +   +      +  +L+E+R    R GQL E  E E   
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1809

Query: 353  AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400
            + L  +  R+   Q E    E      + A  E  + QLER+ ++      + +A A   
Sbjct: 1810 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1869

Query: 401  TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460
             +  +A ++S++ + E +L+   RER      +S    R   +R++ E  L V+ E+RV 
Sbjct: 1870 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1923

Query: 461  ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520
            ++L    E    +   L    ++QL++      +E AS+    +  +    E   + AE 
Sbjct: 1924 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1974

Query: 521  YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579
                +   + R   L+ G      + V  V RL+  + A  +EA +    + P P P  +
Sbjct: 1975 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 2030

Query: 580  PPAGP 584
            PPA P
Sbjct: 2031 PPAHP 2035



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%)

Query: 253  RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312
            R + L+ +QE  Q +     + Q  V +LE+  +   E L  E E     +  R  L   
Sbjct: 915  RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 974

Query: 313  RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369
            +Q L L +   + R   + EE + +R  Q  + R    ++ L A LE E    A+Q+ QL
Sbjct: 975  KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 1029

Query: 370  K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425
            +    E      EE    LE +  K  +E +   +   + +   +E       L+  R +
Sbjct: 1030 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1089

Query: 426  RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485
             +A   +M     + E  R +LE     +L++R+    ++ QE  + Q     +   ++L
Sbjct: 1090 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1139

Query: 486  QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545
            +   G+ ++EL + LA+ + E   R +  + + E  +  LA  Q  +   +    + E+Q
Sbjct: 1140 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1198

Query: 546  RVELVERLQAM 556
            R +L E L+A+
Sbjct: 1199 RRDLGEELEAL 1209


>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
          Length = 1080

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 134/562 (23%), Positives = 228/562 (40%), Gaps = 72/562 (12%)

Query: 25   PGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGF-AQELSRSLSVGL 83
            PG  ++ SEV++ +   +RL  + E   +A L L         L     +E  ++LS  L
Sbjct: 557  PGPLELGSEVSTSV---MRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQL 613

Query: 84   EKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTAT 143
            ++  +  + +        ++  L  + Q   D            +E ++ED   ++  A 
Sbjct: 614  QRQREHYEAT--------IQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQ 665

Query: 144  L-----LNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRK 198
                  L  + L++L  ++     E+     T       +     +GL   +     R K
Sbjct: 666  AQAQHELEIKKLKELMSATEKARREKWISEKTK-----KIKEVTVRGLEPEIQKLIARHK 720

Query: 199  HCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR 258
               R ++SL    L LQ     +    R+ + + EQL++    +  G    E  R    +
Sbjct: 721  QEVRRLKSLHEAEL-LQSDERASQRCLRQAEELREQLEREKEAL--GQQERERARQRFQQ 777

Query: 259  GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRE-RETLEEERQALT 317
             L++E  A +  R        RL   ++E  E L ++    R +  E R+ LEE   ALT
Sbjct: 778  HLEQEQWALQQQRQ-------RLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALT 830

Query: 318  LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA-----QQEHQLKEH 372
              L AE ++    QE R            EL TL+  LE ERQ W      ++E  L   
Sbjct: 831  RALRAEFEKGREEQERR---------HQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881

Query: 373  YQALQEESQAQLEREKEK--SQREAQAAWETQHQLALVQSEVRRL----EGELDTARRER 426
             Q L+EE +   ++E E    + EA  A   +      +S ++RL    E EL    +  
Sbjct: 882  EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSE 941

Query: 427  DALQ-----LEMSLVQARYESQRIQ---LESELAVQLEQRVTERLAQAQESSLRQAASLR 478
              LQ     L+  L +A  E+ R+Q    + E A++  Q V E+L+ ++ S+L Q     
Sbjct: 942  RKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS-SERSNLAQVI--- 997

Query: 479  EHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
               R++ +D     ++E      Q K E+A  + RQQ   E+   R+    AR  E  S 
Sbjct: 998  ---RQEFEDRLAASEEETR----QAKAELATLQARQQLELEEVHRRVKTALARKEEAVSS 1050

Query: 539  NQQLEEQRVELVERLQAMLQAH 560
             +   E  V+  + L+ +L+ H
Sbjct: 1051 LRTQHEAAVKRADHLEELLEQH 1072



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 89/332 (26%), Positives = 152/332 (45%), Gaps = 46/332 (13%)

Query: 269 LTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET---LEEERQALTLRLEAEQQ 325
           L+ +K Q  ++ L++      + L+ +QE    +          E     + L+LE E++
Sbjct: 521 LSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEK 580

Query: 326 RCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEH-------------QLKEH 372
           +  +L  +R  A+   L+  R  ET +A     RQ   Q+EH             QL E 
Sbjct: 581 KQAMLLLQRALAQQRDLTARRVKETEKAL---SRQLQRQREHYEATIQRHLAFIDQLIED 637

Query: 373 YQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER------ 426
            + L E+ +A +   K++ QR  +   + Q Q  L   +++ L    + ARRE+      
Sbjct: 638 KKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKT 697

Query: 427 --------DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR 478
                     L+ E+  + AR++ +  +L+S    +L Q   ER   A +  LRQA  LR
Sbjct: 698 KKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQS-DER---ASQRCLRQAEELR 753

Query: 479 EHHRKQLQDLSGQHQQELASQLAQFKVEMAE---REERQQ---QVAEDYELRLAREQARV 532
           E   ++ + L GQ ++E A Q  Q  +E  +   +++RQ+   +VAE+ E RL ++ AR 
Sbjct: 754 EQLEREKEAL-GQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERE-RLGQQAARQ 811

Query: 533 -CELQSGNQQLEEQRVELVERLQAMLQAHWDE 563
             EL+   QQLEE    L   L+A  +   +E
Sbjct: 812 RAELEELRQQLEESSSALTRALRAEFEKGREE 843



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 93/403 (23%), Positives = 146/403 (36%), Gaps = 96/403 (23%)

Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQ 443
           L R KE ++ EA+      +Q  +      R + +    RR   A +LE  L+QA+ E Q
Sbjct: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQ----RRGAGAARLE-HLLQAKREEQ 304

Query: 444 RIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQF 503
           R +      + L Q+      +A+E   RQA       R  +Q+L  Q ++ L +Q    
Sbjct: 305 RQRSGEGTLLDLHQQKEAARRKAREEKARQA------RRAAIQEL--QQKRALRAQ---- 352

Query: 504 KVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDE 563
           K   AER   +              + RV  ++   Q+L         +    L+A+   
Sbjct: 353 KASTAERGPPENP-----------RETRVPGMRQPAQELSPTPGGTAHQA---LKAN--- 395

Query: 564 ANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623
            N         P     P   SSP PQ+P ++              + VL Q   A D L
Sbjct: 396 -NTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDR------------TQDVLAQD-AAGDNL 441

Query: 624 PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPD------------------------ 659
               P   S+ S      GP  +  H+ Q LE +PD                        
Sbjct: 442 EMMAPSRGSAKS-----RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASS 496

Query: 660 LTSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLET 719
           LT+     F  L AF              P P  +G L   L  A+L+ + +FL ++ ++
Sbjct: 497 LTADNLEKFGKLSAF--------------PEPPEDGTL---LSEAKLQSIMSFLDEMEKS 539

Query: 720 VPQNNENPSVDLLPPKS-GPLTVPSWEEAPQVPRIPPPVHKTK 761
                ++     +P    GPL + S E +  V R+   V + K
Sbjct: 540 GQDQLDSQQEGWVPEAGPGPLELGS-EVSTSVMRLKLEVEEKK 581


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 119/442 (26%), Positives = 195/442 (44%), Gaps = 82/442 (18%)

Query: 193  EHTRRKHCERHIQSL--QTRVLELQQQLAVA-VAADRKKDTMIE--QLDKTLARVVEGWN 247
            E  +    ER  Q +  + R  EL++QLAV  V ADR ++   +  QL KTL ++ +  +
Sbjct: 639  EELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ--D 696

Query: 248  RHEAERTEVLRG-----LQEEHQAAELTRSKQQET-------VTRLEQSLSE-------- 287
              EA + +++       L +   A E T  + QE        +  LEQ L E        
Sbjct: 697  CEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGG 756

Query: 288  -AMEALNRE------------QESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEER 334
             A+EA  R+            +E+    Q E  +L   ++AL  RLE  Q+    L +E+
Sbjct: 757  EAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ 816

Query: 335  DAARAGQLSEHRELETLR---AALEEERQTWAQQEHQLKEHYQALQEES-------QAQL 384
                     E ++ E LR   A LEE+++   +   +L +  + + E+S       QAQL
Sbjct: 817  QTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQL 876

Query: 385  EREKEKSQRE-----------AQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEM 433
            E  KEK++RE           A  A +T   L+ +Q E++RL   L  ++ ERD  +L+ 
Sbjct: 877  EDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDK 936

Query: 434  SLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQ 493
             L+  R   Q ++ E+E   + +     +L   +E   R    L E   K   +L     
Sbjct: 937  ELLAQRL--QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDE--EKNTVELLTDRV 992

Query: 494  QELASQLAQFKVE-MAEREERQ---------QQVAEDYELRLA------REQARVCELQS 537
                 Q+ Q + E M ER  RQ         ++  +D + RLA      +  A + +L+S
Sbjct: 993  NRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLES 1052

Query: 538  GNQQLEEQRVELVERLQAMLQA 559
             NQ L+E R++  ER + +LQ+
Sbjct: 1053 QNQLLQE-RLQAEEREKTVLQS 1073



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 112/430 (26%), Positives = 186/430 (43%), Gaps = 69/430 (16%)

Query: 207 LQTRVLELQQQLAVAVAADRKKDTMIEQLDKT---LARVVEGWNR-------HEAERTEV 256
           L+T+V+ELQ +L      +  K+ +++ L +T   L  V+EG  R        E E T +
Sbjct: 441 LETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTAL 500

Query: 257 LRGLQEE----HQAAELTRSKQQETVTRLEQSLSEAME-----ALNREQESARLQ--QRE 305
              L+EE     Q  E  R + Q    +L +S+ +A +        R++ SA ++  QRE
Sbjct: 501 KGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRE 560

Query: 306 RETLEEER-------QALTLRLEAEQQRCCVLQEERDAARAGQLSE-----HRELETLRA 353
            E   EE        Q     L A +Q    L+ E++     +L E      RELE  RA
Sbjct: 561 LEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEE-ELGEKIEVLQRELEQARA 619

Query: 354 ALEEERQTWAQQEHQLK--EHYQALQEESQAQ------LEREKEKS----QREAQAAWET 401
           +  + RQ    ++  L+  E  + LQ E Q+Q       +RE EK     + EA    E 
Sbjct: 620 SAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGREL 679

Query: 402 QHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLES---------ELA 452
           + Q   +Q  +++L  + + A + +   + E +++  R  +    L              
Sbjct: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739

Query: 453 VQLEQRVTERL-----AQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507
           + LEQ++ E        +A E+ LR      E  ++QL++     Q+E  S  A  +   
Sbjct: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799

Query: 508 AEREERQQQVA----EDYEL-RLAREQARVCE-LQSGNQQLEEQRVEL---VERLQAMLQ 558
           A  EE Q+ +A    E   L R   E+ +  E L+ G  +LEEQ+  L   V+RL   L+
Sbjct: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859

Query: 559 AHWDEANQLL 568
              +++ Q L
Sbjct: 860 KIGEDSKQAL 869



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 82/321 (25%), Positives = 149/321 (46%), Gaps = 47/321 (14%)

Query: 105  QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
            QLQ  L+  ++ A R+     A ++R+ +D + S++  T      LQD       QAL+ 
Sbjct: 871  QLQAQLEDYKEKARREV----ADAQRQAKD-WASEAEKTSGGLSRLQD-EIQRLRQALQA 924

Query: 165  LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAA 224
                  + R    L     QGL    +++   +    R ++ L+ +V  L+ +L      
Sbjct: 925  SQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL------ 978

Query: 225  DRKKDTMIEQLDKTLARVVEGWNRHEAERTEVL--RGLQEEHQAAELTRSKQQETV-TRL 281
            D +K+T+    D    RV  G ++ +  RTE++  R  +++ +  +++  +Q + + TRL
Sbjct: 979  DEEKNTVELLTD----RVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRL 1034

Query: 282  EQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQ 341
              S          ++ SA L Q     LE + Q L  RL+AE++   VLQ          
Sbjct: 1035 ASSEGF-------QKPSASLSQ-----LESQNQLLQERLQAEEREKTVLQSTNRKLE--- 1079

Query: 342  LSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ---EESQAQLER---EKEKSQREA 395
                R+++ L   +E+ERQ    Q+ QL    +AL+   +E++ ++ER    ++K+QRE 
Sbjct: 1080 ----RKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135

Query: 396  QAAWETQHQLALVQSEVRRLE 416
            +   E   QL   Q+ ++ LE
Sbjct: 1136 EEQHEVNEQL---QARIKSLE 1153



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 90/452 (19%), Positives = 173/452 (38%), Gaps = 55/452 (12%)

Query: 211 VLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
           +L  QQ+ A   + D  K T+   L        EG +  E      +  + E+ Q   + 
Sbjct: 298 LLRDQQEAAPPGSVDHMKATIYGILR-------EGSSESETSVRRKVSLVLEKMQPLVMV 350

Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVL 330
            S   + V   +  L+  +E L R+ +    + ++R+ LE  +  L  +LE + + C  L
Sbjct: 351 SSGSTKAVAG-QGELTRKVEELQRKLDE---EVKKRQKLEPSQVGLERQLEEKTEECSRL 406

Query: 331 QEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKE------HYQALQEESQAQL 384
           QE  +  +      ++EL+ ++  L++        E Q+ E      H Q  +   +  L
Sbjct: 407 QELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLL 466

Query: 385 E---REKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE 441
           +     +E  +   +     + QL L + E+  L+G L      RD    E+  V+ +Y+
Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQ---EVEHVRQQYQ 523

Query: 442 SQRIQL--------ESELAVQLEQRVTERLAQAQESSLRQAASLREH----HRKQLQDLS 489
               QL        +    ++ E++    L +  +  L + +    H     +K  +DL 
Sbjct: 524 RDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLR 583

Query: 490 GQHQ---------QELASQLAQFKVEMAEREERQQQVA-------EDYELRLAREQARVC 533
              Q         +E+  +L + K+E+ +RE  Q + +       E  +  L R Q  + 
Sbjct: 584 ATKQELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK 642

Query: 534 ELQSGNQQLE---EQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQ 590
           ELQ+  Q  E     R   +E+  A+L+   D   +L    L                 +
Sbjct: 643 ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK 702

Query: 591 EPEKEERRVWTMPPMAVALKPVLQQSREARDE 622
                E     +     A++  L++++E  DE
Sbjct: 703 AKMVAEAEATVLGQRRAAVETTLRETQEENDE 734



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 77/349 (22%), Positives = 146/349 (41%), Gaps = 20/349 (5%)

Query: 104  GQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALE 163
            GQ Q  L  + +   +   +   G    EE     D T   LN + L+ +   S  QAL+
Sbjct: 813  GQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN-KELEKIGEDSK-QALQ 870

Query: 164  ELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVA 223
            +L  +    +        D Q  R A D      K     +  LQ  +  L+Q L  + A
Sbjct: 871  QLQAQLEDYKEKARREVADAQ--RQAKDWASEAEK-TSGGLSRLQDEIQRLRQALQASQA 927

Query: 224  ----ADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVT 279
                A   K+ + ++L + L +  E   R + +R   L+GL+E+    E    +++ TV 
Sbjct: 928  ERDTARLDKELLAQRL-QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE 986

Query: 280  RLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-ERDAAR 338
             L   ++   + +++ +     ++  R+ LE ++ +L  + +  + R    +  ++ +A 
Sbjct: 987  LLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSAS 1046

Query: 339  AGQLSEHRELETLRAALEEERQTWAQQ-----EHQLKEHYQALQEESQAQLEREKEKSQR 393
              QL    +L   R   EE  +T  Q      E ++KE    +++E Q   +++ + S R
Sbjct: 1047 LSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLR 1106

Query: 394  EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYES 442
                    + Q+   + E+ RL+G    A+RE +        +QAR +S
Sbjct: 1107 VKAL----KRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 99/478 (20%), Positives = 188/478 (39%), Gaps = 75/478 (15%)

Query: 81   VGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDS 140
            +GLE+ LK+  G   +   E+V  +L+  LQ  R  A +  L     + + EE S     
Sbjct: 740  LGLEQQLKETRGL--VDGGEAVEARLRDKLQ--RLEAEKQQLEEALNASQEEEGSL---- 791

Query: 141  TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
                              A A   L  R    + G      + Q L  AL+ E  +R   
Sbjct: 792  ------------------AAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR--- 830

Query: 201  ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260
                + L+    EL++Q  +    DR  D + ++L+K      +   + +A+  +     
Sbjct: 831  ----EVLRRGKAELEEQKRLL---DRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKA 883

Query: 261  QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320
            + E   A+           +    LS   + + R +++ +  Q ER+T   +++ L  RL
Sbjct: 884  RREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRL 943

Query: 321  EAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALEEERQT----------WAQQEHQL 369
            +  +Q     +  +D  RA QL    E +  L   L+EE+ T             Q  QL
Sbjct: 944  QGLEQEAENKKRSQDD-RARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQL 1002

Query: 370  KEHYQALQEESQAQ-LEREKEKSQRE----------AQAAWETQHQLALVQSEVRRLEGE 418
            +   + +QE S  Q LE +K   +R+          ++   +    L+ ++S+ + L+  
Sbjct: 1003 RT--ELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQER 1060

Query: 419  LDTARRERDALQLEMSLVQARYESQRIQLESEL--------AVQLEQRVTERLAQAQESS 470
            L    RE+  LQ     ++ + +   IQ+E E          + L  +  +R     E  
Sbjct: 1061 LQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEE 1120

Query: 471  LRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528
            + +   LR+  ++++++     Q E+  QL Q +++  E++  ++      E  L  E
Sbjct: 1121 IERLDGLRKKAQREVEE-----QHEVNEQL-QARIKSLEKDSWRKASRSAAESALKNE 1172


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 92/407 (22%), Positives = 185/407 (45%), Gaps = 37/407 (9%)

Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
           RDAL  E  R    +   + L+ +  ELQ++L +  +   +    ++ L + L       
Sbjct: 199 RDALSLELYRNTITD---EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL------- 248

Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSL--SEAMEALNREQESARLQQR 304
                ER ++L   Q+    A+    + Q    +L+  +  +E    LN++QE    +Q 
Sbjct: 249 -----ERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE 303

Query: 305 ERETLEEER---QALTLRLEAE----QQRCCVLQEERDAARAGQL--SEHRELETLRAAL 355
           E+   +EE+   Q L +R + E    Q+     QEE+   +  ++   E +  E      
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363

Query: 356 EEERQTWAQQE--HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVR 413
           E+E + W Q+E   +  E  Q  +EE   Q E+ +E+ ++  +  W  + ++     ++R
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR 423

Query: 414 RLEGELDTARRERDALQLEMSL----VQARYESQRIQLESELAVQLE---QRVTERLAQA 466
             E E+   R+E    +LE  +     + R   +++Q E E   + E   QR  E++ + 
Sbjct: 424 EQEEEM--WRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQ 481

Query: 467 QESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLA 526
           +E + RQ   L++  +   Q+     Q+E   +  +   E  E+ +RQ++   + E+RL 
Sbjct: 482 EEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLW 541

Query: 527 REQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLP 573
           +++ ++ E +   Q+LEE+  +L ++ + +  A  +  +Q L T  P
Sbjct: 542 QQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP 588



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 56/267 (20%), Positives = 123/267 (46%), Gaps = 21/267 (7%)

Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
           +ER+ L  E    T+  E  +++   LQE+     + +      ++ L+  LE  +    
Sbjct: 197 KERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLP 256

Query: 364 QQEHQ-----LKEHYQALQEESQAQLEREK---EKSQREAQAAWETQHQLALVQSEVRRL 415
           QQ+ Q     L +  Q++  + QAQ+E  +     +Q++ +  W  + ++   + E +  
Sbjct: 257 QQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ--EQEEKMC 314

Query: 416 EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRV---TERLAQAQESSLR 472
           E EL    +E    + E  + +   + ++I+ + +   + E+++    E++ + +E   R
Sbjct: 315 EQELKIREQEEKMWRQEEKMHE---QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWR 371

Query: 473 QAASLREHHRK-QLQDLSGQHQQELASQLAQFKVEMAEREER----QQQVAEDYELRLAR 527
           Q   +RE   K Q Q+     Q+E   +  + + E   R+E+    Q +   + E  + R
Sbjct: 372 QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431

Query: 528 EQARVCELQSGNQQLEEQRVELVERLQ 554
           ++ ++ EL+   Q  EE+  E+ E++Q
Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQ 458


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 107/398 (26%), Positives = 182/398 (45%), Gaps = 50/398 (12%)

Query: 184  QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243
            QGL  +L      ++  E+ + +L+    +LQ+QLA        ++  +EQ  +   R V
Sbjct: 802  QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861

Query: 244  EGWNRHEAERTEVLR---GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEA--LNREQES 298
            E   R   E+  + +   GL  +  AAE       E  TRL     EA+E      +++ 
Sbjct: 862  EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE-KEALEGSLFEVQRQL 920

Query: 299  ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358
            A+L+ R RE LE E QAL L  E        L+++  A +             +A+L++E
Sbjct: 921  AQLEAR-REQLEAEGQALLLAKETLTGELAGLRQQIIATQE------------KASLDKE 967

Query: 359  RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAW-ETQHQLALVQSEVRRLEG 417
                AQ+  Q +   QA   E +A  E + ++ QRE +AAW E + + A +QS+++R + 
Sbjct: 968  --LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQE 1025

Query: 418  ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
            EL                  AR E+++ +L  E+A  L+Q   E L  A ES  +QA SL
Sbjct: 1026 EL-----------------LARLEAEKEELSEEIAA-LQQERDEGLLLA-ESEKQQALSL 1066

Query: 478  REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQ--------VAEDYELRLAREQ 529
            +E  +  L +     +  LA+   + + +  + + RQ+Q         +E  +LR  RE+
Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126

Query: 530  ARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567
            A     Q   ++L+EQ  +L ++  + L+   +   QL
Sbjct: 1127 AAAAHAQE-VRRLQEQARDLGKQRDSCLREAEELRTQL 1163



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 105/342 (30%), Positives = 153/342 (44%), Gaps = 48/342 (14%)

Query: 201  ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260
            E   Q+LQ RV  LQ+Q+A +          +E+L+  LA+V E     E    + +RGL
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES----EGALRDKVRGL 1731

Query: 261  QEE--HQAAEL--TRSKQ---QETVTRLE---QSLSEAMEALNREQESARLQQ----RER 306
             E     +A L  TR K    Q+ +T  E   Q L E ++A  +    AR Q      + 
Sbjct: 1732 TEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQV 1791

Query: 307  ETLEEERQALTL-RLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER------ 359
            +TL  E   L L R+EAE Q    LQ+ R+  R  Q  E   L T++   +E R      
Sbjct: 1792 QTLRGEVADLELQRVEAEGQ----LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERL 1847

Query: 360  ----QTWAQQEHQLKE-HYQALQ-EESQAQLEREKEKSQREAQAAWETQHQLALVQSEV- 412
                +  AQ E + +E    AL+ E+ +  L R  +K +RE   + E   +L+  +  + 
Sbjct: 1848 GSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLD 1907

Query: 413  RRLEG-ELDTARRERDALQLEMSLVQARYESQRIQLE---SELAVQLEQRVTERLAQAQE 468
            R L G EL+ A  +R   QLE  +V         QLE    +  ++L+Q V ERL  AQ 
Sbjct: 1908 RTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV-ERLRSAQA 1966

Query: 469  SSLRQAASLREHHR-------KQLQDLSGQHQQELASQLAQF 503
             + R   +    HR       +Q+  L GQ QQEL    A F
Sbjct: 1967 QTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 133/548 (24%), Positives = 228/548 (41%), Gaps = 92/548 (16%)

Query: 83  LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDS----FDS 138
           LEK+   KD ++ +  +ES+R Q Q  L+T      +  L   A +   + +S      S
Sbjct: 414 LEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGS 473

Query: 139 DSTATLLNTRPLQDLSPSSSAQALEELFP-RYTSLRPGP--------------------P 177
           + TA   N   L+ LS   +        P R  S R GP                     
Sbjct: 474 ERTADASN-GSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQ 532

Query: 178 LNPPDFQG-----------LRDALDSEHTRRKHCERHIQSLQTR---VLELQQQLAVAVA 223
           L   D +G           LR  L    + R+  E  +Q L+ +    ++  +     V 
Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592

Query: 224 ADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQ 283
             R  + ++ +    LA  ++       ++ E LR  +E+ QAA+    +Q++   RLE+
Sbjct: 593 RLRSANELLSREKSNLAHSLQ----VAQQQAEELRQEREKLQAAQEELRRQRD---RLEE 645

Query: 284 SLSEAMEALNREQESARLQQRERETLEEERQAL--------------TLRLEAEQQRCCV 329
              +A++   R +       R+ E LE +R  L              TL+ +  Q     
Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705

Query: 330 LQEERDAARAGQLSEHRELETLRA----------ALEEERQTWAQQEHQLKEHYQALQEE 379
           + E    A AG++     +  LRA           L    ++ AQ +  L      L+EE
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765

Query: 380 SQAQLEREKEKSQREAQAAWETQHQL--ALVQSEVRR--LEGELDTARRERDALQLEMSL 435
             A L+  + ++++EA  A E Q +L    ++ EV R  LEG L  A + ++A  LE  L
Sbjct: 766 KSA-LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA--LEQQL 822

Query: 436 VQARYESQRIQLE-SELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQ 494
              R+E  ++Q + ++L+ QL  R  E L QA+  + RQ  +L         + + + ++
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQE-LEQARREAQRQVEAL---------ERAAREKE 872

Query: 495 ELASQLAQFKVEMAEREERQQQVAED-YELRLARE--QARVCELQSGNQQLEEQRVELVE 551
            LA + A   V++   E   + ++E+   LRL +E  +  + E+Q    QLE +R +L  
Sbjct: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932

Query: 552 RLQAMLQA 559
             QA+L A
Sbjct: 933 EGQALLLA 940



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 113/396 (28%), Positives = 170/396 (42%), Gaps = 80/396 (20%)

Query: 188  DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247
            +AL      R   E  +  L+     LQ  L+            +  L+++LA+     N
Sbjct: 708  EALTKAEAGRVELELSMTKLRAEEASLQDSLS-----------KLSALNESLAQDKLDLN 756

Query: 248  RHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQE--------SA 299
            R  A+  E    LQ   + AE     Q+ TV R EQ   E +E L  EQE        S 
Sbjct: 757  RLVAQLEEEKSALQGRQRQAE-----QEATVAREEQ---ERLEELRLEQEVARQGLEGSL 808

Query: 300  RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER 359
            R+ ++ +E LE+  Q  TLR E  Q     LQE+   A+  +    RE E  +A  E +R
Sbjct: 809  RVAEQAQEALEQ--QLPTLRHERSQ-----LQEQ--LAQLSRQLSGREQELEQARREAQR 859

Query: 360  QTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGEL 419
            Q                  E+  +  REKE   +E         QL   + E R L  E 
Sbjct: 860  QV-----------------EALERAAREKEALAKEHAG---LAVQLVAAEREGRTLSEEA 899

Query: 420  DTARRERDALQLEMSLVQ---ARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAAS 476
               R E++AL+  +  VQ   A+ E++R QLE+E          + L  A+E+   + A 
Sbjct: 900  TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE---------GQALLLAKETLTGELAG 950

Query: 477  LREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREE----RQQQVAEDYEL-RLARE-QA 530
            LR+      Q ++ Q +  L  +L   K+  AERE     R+Q+ A + +L RL RE +A
Sbjct: 951  LRQ------QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA 1004

Query: 531  RVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
               EL++   QL+ Q     E L A L+A  +E ++
Sbjct: 1005 AWRELEAERAQLQSQLQREQEELLARLEAEKEELSE 1040



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 130/514 (25%), Positives = 198/514 (38%), Gaps = 80/514 (15%)

Query: 74   ELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREE 133
            E +R+ +  L   L   +G     E E  R ++Q     ++    R  L  G G  R   
Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451

Query: 134  DSFDSDSTATLLNTRPLQDLSPSSSAQALE-----ELFPRYTSLRPGPPLNP--PDF--Q 184
             +         +   P +D     S + L      E  P      PGP  +P  PD   +
Sbjct: 1452 PA------PRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPE 1505

Query: 185  GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE 244
             +R AL       +  +R    L+T+   L +QLA   A      +   QL K +A    
Sbjct: 1506 AVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE--- 1562

Query: 245  GWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR 304
                 EA R+                          ++  LS     L  ++ES R  +R
Sbjct: 1563 ---SEEARRS--------------------------VDGRLSGVQAELALQEESVRRSER 1593

Query: 305  ERE-------TLEEERQALTLRLEAEQQRCCVLQE-----ERDAARAGQL---SEHR--E 347
            ER        TLE   QA    L A Q++   ++      E D  R  ++   SE R  +
Sbjct: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653

Query: 348  LETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLAL 407
            LE  R +LE E Q         +   QALQ+   + L+R+   S+ +A     T  +L  
Sbjct: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDS-LQRQVADSEVKAGTLQLTVERLNG 1712

Query: 408  VQSEVRRLEGEL-DTARRERDAL-QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ 465
              ++V   EG L D  R   +AL Q   SL   R ++  +Q          Q + ERL  
Sbjct: 1713 ALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDA 1772

Query: 466  AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
            A     RQA S     RKQ   L G+  Q L  ++A  +++  E E + QQ+ E    R 
Sbjct: 1773 A-----RQALS---EARKQSSSL-GEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823

Query: 526  AREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
              E A +  +    Q+L+++R  L ERL ++ +A
Sbjct: 1824 EGEAAALNTV----QKLQDERRLLQERLGSLQRA 1853



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 135/643 (20%), Positives = 242/643 (37%), Gaps = 94/643 (14%)

Query: 27   LNQVSSEVTSQLYASLRLSRQAEATAR--AQLYLPSTSPPHEG----------------L 68
            L Q   E   Q+ A  R +R+ EA A+  A L +   +   EG                L
Sbjct: 850  LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909

Query: 69   DGFAQELSRSLS-VGLEKNLKKKDGSKHIFEMESVRGQLQTMLQ---TSRDTAYRDPLIP 124
            +G   E+ R L+ +   +   + +G   +   E++ G+L  + Q    +++ A  D  + 
Sbjct: 910  EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969

Query: 125  GAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQ 184
                 + E ++  S       +   LQ L     A A  EL      L           Q
Sbjct: 970  AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA-AWRELEAERAQL-----------Q 1017

Query: 185  GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTM-IEQLDKTLARVV 243
                    E   R   E+   S +   L+ ++   + +A   K+  + +++ +KT     
Sbjct: 1018 SQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK 1077

Query: 244  EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAME-----ALNREQES 298
                RH      +   ++ + + A+  + + + TV  L   L +        A    QE 
Sbjct: 1078 LMGTRHSLATISL--EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEV 1135

Query: 299  ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358
             RLQ++ R+ L ++R +     E  + +  +L++ RD  R   L   R+L   +   E +
Sbjct: 1136 RRLQEQARD-LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194

Query: 359  RQTWAQQEHQL------KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQ--- 409
            RQ   +    L      +E  +   EE ++ +++ + +      A  + + +LAL++   
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ---- 465
            + V +  GEL T  +E     +E S ++AR E Q ++ + ++      R+   LA+    
Sbjct: 1255 TAVGKEAGELRTGLQE-----VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGR 1309

Query: 466  ------AQESSLRQAASLREHHRKQLQDLSGQHQQ------ELASQLAQFK--------- 504
                  A++ S R+   LR+   K    L    Q+      +L  Q  +F+         
Sbjct: 1310 LALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS 1369

Query: 505  VEMAEREERQQ-QVAEDYELRLAREQARVCEL------QSGNQQLEEQRVELVERLQAML 557
            +E A   E+QQ   A   EL+L   +A   EL        G  Q  E  +  VE  +   
Sbjct: 1370 LEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAA 1429

Query: 558  QAHWDEANQLLSTTL-----PPPNPPAPPAGPSSPGPQEPEKE 595
            +A        L   L     P P P   P  P+   P E   E
Sbjct: 1430 EAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 9/176 (5%)

Query: 402 QHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE-SELAVQLEQRVT 460
           Q +  L+Q E+ R+E  L  +R ERD L ++ + V  R E Q ++LE  EL  Q  + + 
Sbjct: 80  QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLE-QALRLEPGELETQEPRGLV 138

Query: 461 ERLAQAQESSLRQAASLREHHR--KQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVA 518
            +  + +     + AS R   +  ++ Q    Q  Q L  ++ Q+K   +E E++  + +
Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198

Query: 519 EDYELRLAREQARVCELQSGNQQLEE--QRVELVERLQAMLQAHWDE---ANQLLS 569
            + E +  R+     +L+S   +LEE  QR   + ++ AML+   D+   ANQ LS
Sbjct: 199 GELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALS 254



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 108/437 (24%), Positives = 179/437 (40%), Gaps = 77/437 (17%)

Query: 151 QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTR 210
           QD   +S    + E+  R  S    P L P        +L  E+   +     ++ L  +
Sbjct: 40  QDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQ 99

Query: 211 VLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER------TEVLRGLQEEH 264
               + +LA+      K + + E+L++ L R+  G    +  R       E+ R LQEE 
Sbjct: 100 SRAERDELAI------KYNAVSERLEQAL-RLEPGELETQEPRGLVRQSVELRRQLQEEQ 152

Query: 265 -------QAAELTRSKQQETVTRLEQSLSE------AMEALNREQESARLQQRERETLE- 310
                  QA +  + +Q + V RL+  + +       +E    E+     QQR R+T   
Sbjct: 153 ASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHS 212

Query: 311 EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLK 370
           ++ ++  +RLE EQQR   L +     R          + L   + +    W +   +L 
Sbjct: 213 QDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKEL- 271

Query: 371 EHYQALQEESQAQLEREKEKSQREAQAAWETQH-QLALVQSEV---RRLEGELDTARRER 426
                  E  +A   RE+E       A +  +H +L L+  +V   RRL  E+     ER
Sbjct: 272 -------EHREAAWRREEE----SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF-TER 319

Query: 427 DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486
           D LQL   L +    + R   E+ L +    R+ E  A   E++L + A L+    +QL+
Sbjct: 320 DLLQLGGELAR----TSRAVQEAGLGLSTGLRLAESRA---EAALEKQALLQAQLEEQLR 372

Query: 487 DLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQR 546
           D                KV + E++  QQQ+  D  L  A   ARV EL    ++LE+Q 
Sbjct: 373 D----------------KV-LREKDLAQQQMQSD--LDKADLSARVTELGLAVKRLEKQN 413

Query: 547 VE-------LVERLQAM 556
           +E       L E+L+A+
Sbjct: 414 LEKDQVNKDLTEKLEAL 430



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 112/441 (25%), Positives = 179/441 (40%), Gaps = 90/441 (20%)

Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ-LDKTLARVVEGWNRHEAERTE 255
           +K C    Q L  R  EL+QQ        R +DT   Q L+  L R+ E   R  A   +
Sbjct: 184 KKRCSELEQQLLERSGELEQQ--------RLRDTEHSQDLESALIRLEEEQQR-SASLAQ 234

Query: 256 VLRGLQEEHQAAELTRSKQQETV-------TRLEQSLSEAMEALNREQES---------A 299
           V   L+E+   A        E +       TR  + L     A  RE+ES         +
Sbjct: 235 VNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHS 294

Query: 300 RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQ-----LSEHRELETLRA- 353
           RL    R+ +   R    +++  E+    +  E    +RA Q     LS    L   RA 
Sbjct: 295 RLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE 354

Query: 354 -ALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEV 412
            ALE++    AQ E QL++     ++ +Q Q++ + +K+   A+    T+  LA     V
Sbjct: 355 AALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARV---TELGLA-----V 406

Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQ----LESELAVQLEQRVTERLAQA-- 466
           +RLE +      E+D +  +++      ES R+Q    LE+E    L+Q + + LAQA  
Sbjct: 407 KRLEKQ----NLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRD-LAQAVL 461

Query: 467 --QESSLRQAASLR--EHHRKQLQDLSGQHQQEL----------------------ASQL 500
              ES ++ + S R  +     L+ LSGQ                           +S L
Sbjct: 462 SDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTL 521

Query: 501 AQFKVEMAEREERQQQVAEDYELR---LAREQARVCELQSGNQQLEEQRVELVERLQAML 557
           A     + +R+ + Q +   YE     L   + ++ + +S  + LEEQ   L ++    +
Sbjct: 522 ALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 581

Query: 558 QAHWD---------EANQLLS 569
           QAH D          AN+LLS
Sbjct: 582 QAHEDAQREVQRLRSANELLS 602


>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
          Length = 1133

 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 111/440 (25%), Positives = 187/440 (42%), Gaps = 72/440 (16%)

Query: 203  HIQSLQTRVLELQQQLAVAVAAD---RKKDTMIEQLDKTLARVVEGWNRHEA-------- 251
            H + LQ   L   +++  A +A    R  +++I Q++K  + + E  +R EA        
Sbjct: 708  HEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQE 767

Query: 252  ------ERTEVLRGLQE----EHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
                  +R E LR LQE    + +  E  RS+QQE + ++E  L+E    L +E+     
Sbjct: 768  RELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTA 827

Query: 302  QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
            +Q + E+++                   L+E+R         E  ELE  ++AL EE+++
Sbjct: 828  EQSKAESMQR-----------------ALEEQRKVTAQQMAMERAELERAKSALLEEQKS 870

Query: 362  WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
               +  + +    A   E  AQ +  KE+++REA+ A +   Q           EG L +
Sbjct: 871  VMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQ----------REGTLIS 920

Query: 422  ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
              +E+  L++  S ++A    +  QL +E A   ++R   RL    E     A +LR   
Sbjct: 921  LAKEQAELKIRASELRA----EEKQLAAERAALEQERQELRL----EKERINATALRVKL 972

Query: 482  RKQLQDLSGQHQQELASQLAQFKVEMAEREERQ-QQVAEDYELRLAREQARVCELQSGNQ 540
            R +        + E  S++A  K E  ER  R+ QQV  + + RL   Q +   L+   Q
Sbjct: 973  RAE--------EVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024

Query: 541  QLEEQRVELV-ERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRV 599
             + ++ + L  +RLQ       D A Q L ++L    P A     SS     P     R 
Sbjct: 1025 HMHQEHLSLAQQRLQL------DRARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRW 1078

Query: 600  WTMPPMAVALKPVLQQSREA 619
             + PP  +   P+   +R A
Sbjct: 1079 CSQPPTGLDPSPLHLHARLA 1098



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 109/445 (24%), Positives = 176/445 (39%), Gaps = 91/445 (20%)

Query: 174 PGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIE 233
           P  PL P      R  L S   +++     +Q LQ    ELQ +L  + A   + +  + 
Sbjct: 541 PVQPLLPESLA--RSLLPSTEYQKQLLAAQVQ-LQCSPAELQAELLHSQARLAELEAQVR 597

Query: 234 QLDKTLARVVEGWNRHEAERTEVLRGLQEEHQA-AELTRSKQQETVTRLEQSLSEAMEAL 292
           +L+   A+       HE     +L  LQ++HQA  EL  S  +  +  LE S  +  E L
Sbjct: 598 KLELERAQ-------HEL----LLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERL 646

Query: 293 NREQESARLQQRERETLEEERQALTLRLEAEQQR-----------CCVLQEE-------R 334
            RE E            E   + L+   EAEQ R             + QE+       R
Sbjct: 647 RRENE------------ELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLR 694

Query: 335 DAARAGQLSEHR--ELETLRAALEEERQTWAQQE------------HQLKEHYQALQEES 380
           +  RA  L   R  E +  R  L ++R+  A               HQ+++   +L E S
Sbjct: 695 ELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELS 754

Query: 381 QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY 440
                     SQ       +   QL  +Q  + + + +++    ER   Q  +  ++AR 
Sbjct: 755 SRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDME---EERSRQQEVIGKMEARL 811

Query: 441 ESQRIQLESE---------------LAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485
             Q   LE E                A++ +++VT +    + + L +A S     +K +
Sbjct: 812 NEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSV 871

Query: 486 QDLSGQHQQELASQLAQFKV------EMAERE-ERQQQVAEDYE---LRLAREQA----R 531
               G+ ++ LA++ A+F        E AERE ER  QV    E   + LA+EQA    R
Sbjct: 872 MLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIR 931

Query: 532 VCELQSGNQQLEEQRVELVERLQAM 556
             EL++  +QL  +R  L +  Q +
Sbjct: 932 ASELRAEEKQLAAERAALEQERQEL 956



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 24/76 (31%), Positives = 38/76 (50%), Gaps = 4/76 (5%)

Query: 495 ELASQLAQFKVEMAERE----ERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELV 550
           EL +Q+ + ++E A+ E      QQQ   D EL  +  ++R+  L++  QQ EE+     
Sbjct: 591 ELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRREN 650

Query: 551 ERLQAMLQAHWDEANQ 566
           E L A   +   EA Q
Sbjct: 651 EELSARYLSQCQEAEQ 666


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 121/474 (25%), Positives = 212/474 (44%), Gaps = 68/474 (14%)

Query: 125  GAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQ 184
            G+  E R E S   DS  ++    P Q+ + S        LF R      GP L     +
Sbjct: 1194 GSVCESRPELSGGGDSAPSVWGLEPDQNGARS--------LFKR------GPLLTALSAE 1239

Query: 185  GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE 244
             +  AL   H      ++    L+ +V +L+++L    A   +  T ++ L + L++  E
Sbjct: 1240 AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE 1299

Query: 245  GWNRHEAERT----------EVLRGLQEEHQAAELTRSKQQ---ETVTRLEQSLSEAMEA 291
              ++ E ++           E +  LQ   + AEL R + Q   E +   +++L+  +E 
Sbjct: 1300 EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEH 1359

Query: 292  LNREQESARLQQRERETLEEE----RQALTLR---LEAEQQRCCVLQEERD--AARAGQL 342
            L      AR Q      LEE+    R AL L+   +E+E++R   LQE+ +   A+   L
Sbjct: 1360 LQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKAL 1419

Query: 343  SEH------------RELETLRAALEE-ERQTWAQQEH------QLKEHYQA--LQEESQ 381
             E+             E+ETLR  ++E E+Q   Q+         LK+  Q   LQ+E  
Sbjct: 1420 QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479

Query: 382  AQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE 441
             +LE+ +   +    A  E + +L + + ++R LE + +T R   +   LE+       E
Sbjct: 1480 QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539

Query: 442  SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
            SQR Q++ +L  QL     E LA   E +  +     E  +K +++L GQ + +  + L 
Sbjct: 1540 SQRGQVQ-DLKKQLV--TLECLALELEENHHK----MECQQKLIKELEGQRETQRVA-LT 1591

Query: 502  QFKVEMAER-EERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
               +++ ER +E Q Q ++ ++L  +       ELQ  +Q+++ QR E +E LQ
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLE-SHSTVLARELQERDQEVKSQR-EQIEELQ 1643



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 122/456 (26%), Positives = 200/456 (43%), Gaps = 87/456 (19%)

Query: 182  DFQGLRDALDSE----HTRRKHCERHIQSLQTRVLELQQQLAVA-VAADRKKDTMIEQLD 236
            + Q L+D L+ +    H +       +   +  ++ LQQQL  A    + K+ ++  QLD
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806

Query: 237  KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQ 296
            +          R  A+R + L  LQ+E Q A+    + +E    L+ +L +A   L    
Sbjct: 1807 EA--------QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858

Query: 297  ESARLQQRERETLEEER-------QAL-----TLRLEAEQQRCCVLQEERDAARAGQLSE 344
               +  + +   LEEE        QAL      LR E+ +Q   +L  ++  A   Q  E
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE--QAQE 1916

Query: 345  HRELETLRAALEEERQTWAQQEHQLKEHYQ---ALQEESQAQLEREKEKSQR-------- 393
            H E+ET   AL++   +W Q +  LKE  Q   AL+ ESQ+   +E+    R        
Sbjct: 1917 H-EVET--RALQD---SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEAL 1970

Query: 394  -EAQAAWETQHQLALVQSEV-RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
             +A AA + + Q  L Q+E+ R LE    T +   DA Q     ++   E+ RIQ E E+
Sbjct: 1971 GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE---EALRIQ-EGEI 2026

Query: 452  AVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA-ER 510
              Q + R  E + Q Q++  ++   LR H +++ Q L     Q +   + Q K  +  ER
Sbjct: 2027 QDQ-DLRYQEDVQQLQQALAQRDEELR-HQQEREQLLEKSLAQRVQENMIQEKQNLGQER 2084

Query: 511  EERQ----QQVAEDYELRLAREQARVCELQSGNQQ--------------LEEQRVEL--- 549
            EE +     Q   + +L LA+++  + EL+   Q+              +EEQ ++L   
Sbjct: 2085 EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144

Query: 550  -------VERLQAML------QAHWDEANQLLSTTL 572
                   +ERLQA L      +  W E  Q L+ +L
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSL 2180



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 115/482 (23%), Positives = 214/482 (44%), Gaps = 66/482 (13%)

Query: 147  TRPLQDLSPSSSAQA--LEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHI 204
            T  L++ S    AQ+  + +L    T L         + +  R+ ++    +++H  + +
Sbjct: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL 1653

Query: 205  QSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEH 264
            +  + + L LQ++    +   R + T I  L++ L ++         E T   + +QE  
Sbjct: 1654 ER-RDQELMLQKERIQVLEDQRTRQTKI--LEEDLEQIKLSLRERGRELTTQRQLMQERA 1710

Query: 265  QAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQAL-------T 317
            +  +     Q+ ++  ++  L +  + +  +QE     Q  ++ LE++ Q L       +
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770

Query: 318  LRLEAEQQRCCVLQEE-RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQAL 376
            L L   +Q   VLQ++ ++A   G+L E    ++L++ L+E ++  AQ++ +L E  Q  
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKE----QSLQSQLDEAQRALAQRDQEL-EALQQE 1825

Query: 377  QEESQAQLEREKEKSQREAQAAWETQH--------QLALVQSEVRRLEGELDTARRERDA 428
            Q+++Q Q ER KEK+    Q A E  H        +L   + + RRLE EL    R   A
Sbjct: 1826 QQQAQGQEERVKEKAD-ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA 1884

Query: 429  LQLEMSLVQARYESQR---IQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK-- 483
            L+  +  ++A    Q    + L+ + A Q ++   E  A  Q+S L+  A L+E  ++  
Sbjct: 1885 LEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA-LQDSWLQAQAVLKERDQELE 1943

Query: 484  --QLQDLSGQHQQELASQLAQFKVEM-----AEREERQQQVAEDYELRLARE------QA 530
              + +  S +HQ+E A   A+   E      A  + ++Q + E  EL  + E      QA
Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003

Query: 531  RVCELQSGNQQLEE-----------QRVELVERLQAMLQA---------HWDEANQLLST 570
             +   Q+ ++QLEE           Q +   E +Q + QA         H  E  QLL  
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEK 2063

Query: 571  TL 572
            +L
Sbjct: 2064 SL 2065



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 96/400 (24%), Positives = 185/400 (46%), Gaps = 38/400 (9%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ---LDKTLARVVEGW 246
            L  E   +  C R   + Q R   LQ  LA    A+++++ + E+   L+  L +  E  
Sbjct: 620  LQLEEENQSVCSRMEAAEQARNA-LQVDLA---EAEKRREALWEKNTHLEAQLQKAEEAG 675

Query: 247  NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306
               +A+  ++    +E  +    +R +Q+   T+LEQ   EA     R++E      +E+
Sbjct: 676  AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA----KRQEEVLARAVQEK 731

Query: 307  ETLEEERQALTLRLEA-EQQRCCVLQEERDAARAGQLSE---------HRELETLRAALE 356
            E L  E+ AL +RL+A E+ R  + ++ +  + A +L E         +  +E  +  LE
Sbjct: 732  EALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791

Query: 357  EERQTWAQQEHQLKEHYQALQ-----EESQAQLERE---KEKSQREAQAAWETQHQLALV 408
             + QT  Q +  ++   + L+     E SQA+ ER+   ++ +Q E +     + Q A  
Sbjct: 792  VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH 851

Query: 409  QSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE 468
            + EV +L  + +   +ER   Q E++      E ++++LE  L    EQ+      QAQ 
Sbjct: 852  EKEVNQLREKWE---KERSWHQQELAKALESLEREKMELEMRLK---EQQTEMEAIQAQR 905

Query: 469  SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528
               R  A   E    Q+Q  + + +  L   L Q + E+A+  ++ +++ +D +++  +E
Sbjct: 906  EEERTQA---ESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962

Query: 529  QARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568
            Q     LQ+  Q+ + +  E   + +  L A  +E++ LL
Sbjct: 963  QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 112/474 (23%), Positives = 201/474 (42%), Gaps = 52/474 (10%)

Query: 201  ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEG---WNRHEAERTEVL 257
            E+ ++  Q  + ELQ+           KD + +QL     +V E     ++ E E   + 
Sbjct: 1735 EKEVECQQEHIHELQEL----------KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784

Query: 258  RGLQEEHQAAELTRSKQQETVTRLEQSLSEA---MEALNREQESARLQQRERETLEEERQ 314
            + LQE  +  EL     Q  +   +++L++    +EAL +EQ+ A   Q + E ++E+  
Sbjct: 1785 QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA---QGQEERVKEKAD 1841

Query: 315  ALTLRLEAE----QQRCCVLQEERDAARAGQLSEHRELETLRA-ALEEERQTWAQQEHQL 369
            AL   LE      ++R   LQ+ ++ AR  +L E   +E  R  ALEE       +  + 
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQAR--RLEEELAVEGRRVQALEEVLGDLRAESREQ 1899

Query: 370  KEHYQALQEESQAQLEREKEKSQREAQAAW-ETQHQLALVQSEVRRLEGELDTARRERDA 428
            ++   ALQ++  A+  +E E   R  Q +W + Q  L     E+  L  E  ++R + +A
Sbjct: 1900 EKALLALQQQC-AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA 1958

Query: 429  LQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL--- 485
             +     +Q         L+ +    LEQ    R  +A  ++L+ +    + H +QL   
Sbjct: 1959 ARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEA 2018

Query: 486  ----------QDLSGQHQ-QELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCE 534
                      QDL  Q   Q+L   LAQ   E+  ++ER+Q + +    R+  ++  + E
Sbjct: 2019 LRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV--QENMIQE 2076

Query: 535  LQSGNQQLEEQRV----ELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQ 590
             Q+  Q+ EE+ +    + V  LQ  L     E  +L  T         P +  +SP  +
Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136

Query: 591  EPEK----EERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLL 640
            +  K    E R    +  +  AL+    +  E R++       L  + + +S L
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 103/405 (25%), Positives = 191/405 (47%), Gaps = 68/405 (16%)

Query: 204  IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR---GL 260
            ++ +Q    E+Q++L+ +        T +EQL +   R  E   R   E+  ++R    L
Sbjct: 682  LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741

Query: 261  QEEHQAAELTRSKQQETVTRL-------EQSLSEAMEA-----LNREQESARLQQ--RER 306
            +   QA E  R    E +  L       E SL EA +      + + Q   ++Q   + +
Sbjct: 742  EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801

Query: 307  ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE 366
            E ++ E + L L L+ E+ +    ++ERDAA        +E +T   ALE+++    ++ 
Sbjct: 802  EVIQGEVRCLKLELDTERSQA---EQERDAAARQLAQAEQEGKT---ALEQQKAAHEKEV 855

Query: 367  HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426
            +QL+E ++  +   Q +L +  E  +RE     E + +L   Q+E+  ++     A+RE 
Sbjct: 856  NQLREKWEKERSWHQQELAKALESLEREKM---ELEMRLKEQQTEMEAIQ-----AQREE 907

Query: 427  DALQLEMSLVQARYESQR---------IQLESELAVQLEQRVTERLAQ--------AQES 469
            +  Q E +L Q + E+++         +Q + ELA   +Q   ERL Q         QE+
Sbjct: 908  ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ--LERLRQDMKVQKLKEQET 965

Query: 470  SLRQAASLREHHRKQLQDLSGQHQQELA------SQLAQFKVEMAEREE--RQQQVAEDY 521
            +      L+E  R +L++ + QH+ +LA      S L Q K+++ ++ E  + Q VA+D 
Sbjct: 966  TGILQTQLQEAQR-ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024

Query: 522  ELRLARE--QARVCELQSGN---QQLEEQR----VELVERLQAML 557
              RL  +  Q ++ E Q  N   ++LE ++    + L+E+ Q +L
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 115/530 (21%), Positives = 226/530 (42%), Gaps = 63/530 (11%)

Query: 27   LNQVSSEVTSQLYASLRLSRQAEATARA----QLYLPSTSPPHEGLDGFAQELSRSLSVG 82
            L Q+  E   Q     R  ++ EA  R     ++ L +     + L    Q LS +  + 
Sbjct: 710  LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL- 768

Query: 83   LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTA 142
            LE +L +      + E+   +GQL+  +QT   T  ++ +       + E D+  S +  
Sbjct: 769  LESSLFEAQQQNSVIEV--TKGQLEVQIQTV--TQAKEVIQGEVRCLKLELDTERSQAEQ 824

Query: 143  TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHT-RRKHCE 201
                    +D +    AQA +E     T+L      +  +   LR+  + E +  ++   
Sbjct: 825  E-------RDAAARQLAQAEQE---GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELA 874

Query: 202  RHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQ 261
            + ++SL+   +EL+ +L       +++ T +E +            + E ERT+    L 
Sbjct: 875  KALESLEREKMELEMRL-------KEQQTEMEAIQA----------QREEERTQAESALC 917

Query: 262  EEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ-RERET-------LEEER 313
            +     E  R    ET+ + ++ L++A + L R ++  ++Q+ +E+ET       L+E +
Sbjct: 918  QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977

Query: 314  QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHY 373
            + L       +     LQEE  +    ++   +++E L++ L  +  +    E +++E  
Sbjct: 978  RELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037

Query: 374  QALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEM 433
            +  QE ++ Q E E+EK+             L+L++ E R L  +   + R+++   L  
Sbjct: 1038 RETQEYNRIQKELEREKASL----------TLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087

Query: 434  SLVQARYESQRIQLESELAVQLEQRVTERLAQ--AQESSLRQAASLREHHRKQLQDLSGQ 491
             + +A+ E + +  + EL   L Q V E+ A   AQE+ L +   L   H  + Q  +  
Sbjct: 1088 DMQEAQGEQKELSAQMEL---LRQEVKEKEADFLAQEAQLLE--ELEASHITEQQLRASL 1142

Query: 492  HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQ 541
              QE  +   Q ++   E  + +   AE      A+ QA++  L S  QQ
Sbjct: 1143 WAQEAKAAQLQLRLRSTE-SQLEALAAEQQPGNQAQAQAQLASLYSALQQ 1191



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 100/416 (24%), Positives = 180/416 (43%), Gaps = 45/416 (10%)

Query: 224  ADRKKDTMIEQL----DKTLARVVEGWNR----HEAERTEVLRGLQEEHQAAELTRSKQQ 275
            A+++  T +EQ     +K + ++ E W +    H+ E  + L  L+ E    E+ R K+Q
Sbjct: 836  AEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEM-RLKEQ 894

Query: 276  ETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV---LQE 332
            +T    E    +A     R Q  + L Q + ET +E    L   L+ +++       L+ 
Sbjct: 895  QT----EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER 950

Query: 333  ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQ 392
             R   +  +L E      L+  L+E ++   +   Q ++   ALQEES + L+ +K   Q
Sbjct: 951  LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ-DKMDLQ 1009

Query: 393  REAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELA 452
            ++ +   + + QL       R +E E+    RE      E + +Q   E ++  L   L 
Sbjct: 1010 KQVE---DLKSQLVAQDDSQRLVEQEVQEKLRETQ----EYNRIQKELEREKASLTLSL- 1061

Query: 453  VQLEQRV-----TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507
            ++ EQR+      + + Q + S+LRQ     +  +K+L       +QE+  + A F  + 
Sbjct: 1062 MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121

Query: 508  AER-EERQQQVAEDYELR--LAREQARVCELQ----SGNQQLE----EQRVELVERLQAM 556
            A+  EE +     + +LR  L  ++A+  +LQ    S   QLE    EQ+     + QA 
Sbjct: 1122 AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ 1181

Query: 557  LQAHWDEANQLLSTTLPPPNPPAPPAGPSSP---GPQEPEKEERRVWTMPPMAVAL 609
            L + +    Q L +      P     G S+P   G +  +   R ++   P+  AL
Sbjct: 1182 LASLYSALQQALGSVC-ESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTAL 1236



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 94/380 (24%), Positives = 167/380 (43%), Gaps = 48/380 (12%)

Query: 204 IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV--EGWNRHEAERTEVLRGL- 260
           ++ L+T   EL +  A      +++   ++Q+ K + +V+  EG N  +    E    L 
Sbjct: 313 VEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELD 372

Query: 261 -----QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA 315
                Q ++Q A+   +  +  +TR  Q++ +  + L   QE+  L Q++ +  EEE +A
Sbjct: 373 SSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKA 432

Query: 316 LTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQA 375
           L  RL+        L  ERD      +    E++    +L +ER+   +   +L++  + 
Sbjct: 433 LRQRLQK-------LTGERDTLAGQTVDLQGEVD----SLSKERELLQKAREELRQQLEV 481

Query: 376 LQEES--------QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427
           L++E+        + QL+ +  + Q+E     E Q +L L   E  RL+  L     ++ 
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQKE-----EQQEELHLAVRERERLQEMLMGLEAKQS 536

Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
               E+  ++   ES    LE EL  Q +  VT  LA+A E S+ + +S     + ++ D
Sbjct: 537 ESLSELITLREALESS--HLEGELLRQEQTEVTAALARA-EQSIAELSSSENTLKTEVAD 593

Query: 488 LSGQH------QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQ 541
           L           + LA        ++ + EE  Q V    E   A EQAR   LQ    +
Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRME---AAEQARNA-LQVDLAE 649

Query: 542 LEEQRVELVER---LQAMLQ 558
            E++R  L E+   L+A LQ
Sbjct: 650 AEKRREALWEKNTHLEAQLQ 669



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 124/574 (21%), Positives = 223/574 (38%), Gaps = 80/574 (13%)

Query: 29   QVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSP---PHEGLDGFAQELSRSLSVGLEK 85
            ++  E   Q+  SLR  R  E T + QL          P +   G  + +   L    +K
Sbjct: 1679 KILEEDLEQIKLSLR-ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILR---DK 1734

Query: 86   NLKKKDGSKHIFEMESVRGQLQTMLQ--------TSRDTAYRDP---LIPGAGSERREED 134
              + +   +HI E++ ++ QL+  LQ        TS   + R+    ++     E RE+ 
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794

Query: 135  SFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEH 194
                 S  + L+       + +   Q LE L       +            L+ AL+  H
Sbjct: 1795 ELKEQSLQSQLDEA---QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAH 1851

Query: 195  TRRKHCERHIQSLQTRVLELQQQLAVAV--------------AADRKKDTMIEQLDKTLA 240
               K     +Q  + +   L+++LAV                A  R+++  +  L +  A
Sbjct: 1852 MTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCA 1911

Query: 241  R-----------VVEGWNRHEA---ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS 286
                        + + W + +A   ER + L  L+ E Q++       +     L+++L 
Sbjct: 1912 EQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971

Query: 287  EAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE----ERDAARAGQL 342
            +A  AL  +++    Q     +LE     L   L+A Q     L+E    +    +   L
Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031

Query: 343  SEHRELETLRAAL--EEERQTWAQQEHQLKEHYQA-------LQEESQAQLEREKEKSQR 393
                +++ L+ AL   +E     Q+  QL E   A       +QE+     ERE+E+ + 
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091

Query: 394  EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV 453
              Q+  E Q  LA  + E+     EL   ++  +   L  S   +  E Q ++L+S    
Sbjct: 2092 LHQSVRELQLTLAQKEQEIL----ELRETQQRNNLEALPHSHKTSPMEEQSLKLDS---- 2143

Query: 454  QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER 513
             LE R+   L + Q ++LRQ  +     R++ QDL        A  LAQ K  ++  +E 
Sbjct: 2144 -LEPRLQRELERLQ-AALRQTEAREIEWREKAQDL--------ALSLAQTKASVSSLQEV 2193

Query: 514  QQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
               +      R + +Q    EL+   + LE++R+
Sbjct: 2194 AMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 105/446 (23%), Positives = 181/446 (40%), Gaps = 102/446 (22%)

Query: 207  LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH----EAERTEVLRGLQE 262
            LQ +V +L+ QL     + R    ++EQ  +   R  + +NR     E E+  +   L E
Sbjct: 1008 LQKQVEDLKSQLVAQDDSQR----LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063

Query: 263  EHQAAELTR---SKQQETVTRLEQSLSEAM---EALNREQESARLQQRERET--LEEERQ 314
            + Q   + +   S +Q+ ++ L Q + EA    + L+ + E  R + +E+E   L +E Q
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123

Query: 315  ALTLRLEA-----EQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
             L   LEA     +Q R  +  +E  AA+        E +    A E++    AQ + QL
Sbjct: 1124 LLE-ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182

Query: 370  KEHYQALQEESQAQLEREKEKS--------------------------------QREAQA 397
               Y ALQ+   +  E   E S                                  EA A
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242

Query: 398  A---------WETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQ----------A 438
            +         W+TQ    +++ +V++LE  L     E+  +  E+  +Q          +
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302

Query: 439  RYESQRIQLESE----------LAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDL 488
            ++E ++  LESE          L  +L +   +R+    E  L QAA  +E+   Q++ L
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA--KENLTAQVEHL 1360

Query: 489  -------------SGQHQQELASQLAQFKV---EMAEREERQQQVAEDYELRLAREQARV 532
                         +G  +++L +  +  K+   E+    ER Q + E  EL++A+ +A  
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420

Query: 533  CELQSGNQQLEEQRVELVERLQAMLQ 558
              L    Q L E R E VE L+  +Q
Sbjct: 1421 ENLALLTQTLAE-REEEVETLRGQIQ 1445



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 86/360 (23%), Positives = 134/360 (37%), Gaps = 56/360 (15%)

Query: 207 LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQA 266
           L+ +VL LQQQ+A   AA  +K                            L+  QE  Q 
Sbjct: 20  LEEQVLALQQQMAENQAASWRK----------------------------LKNSQEAQQR 51

Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
                 K Q  V +      E  + L  E     + QR     E     L +RLE EQQR
Sbjct: 52  QATLVRKLQAKVLQYRSWCQELEKRL--EATGGPIPQRWENVEEPNLDELLVRLEEEQQR 109

Query: 327 CCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLER 386
           C  L E     R          + LR  +E+    W++   +L      +++ESQ Q+E+
Sbjct: 110 CESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDEL------MRKESQWQMEQ 163

Query: 387 EKEKSQREAQAAWETQHQLALVQSEV--RRLEGELDTARRERDALQLEMSLVQARYESQR 444
           E  K   +     E    L+L +  V  RR   E+ +A  +RD ++L+   V  R     
Sbjct: 164 EFFKGYLKG----EHGRLLSLWREVVTFRRHFLEMKSA-TDRDLMELKAEHV--RLSGSL 216

Query: 445 IQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
           +     L V  + R      +       Q   L     ++L+  + +  QEL    +Q  
Sbjct: 217 LTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA-KTQELEKEAHERSQELIQLKSQGD 275

Query: 505 VEMAEREER----------QQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
           +E AE ++R           Q+  EDYE  +   +  V  L++ + +L E    L    Q
Sbjct: 276 LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQ 335



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 110/474 (23%), Positives = 186/474 (39%), Gaps = 59/474 (12%)

Query: 38   LYASLRLSRQAE--ATARAQLYLPSTSPPHEGLDGFAQ------ELSRSLSVGLEKNLKK 89
            L A  + SR  E  A ARA+    +    H  L G  Q      ELSRSL          
Sbjct: 1945 LRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQAS 2004

Query: 90   KDGSK-HIFEMESV----RGQLQTM-LQTSRDTAYRDPLIPGAGSERR---EEDSFDSDS 140
             D  + H  ++E       G++Q   L+   D       +     E R   E +     S
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064

Query: 141  TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTR-RKH 199
             A  +    +Q+       +  EE+   + S+R    L     Q  ++ L+   T+ R +
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE---LQLTLAQKEQEILELRETQQRNN 2121

Query: 200  CERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRG 259
             E    S +T  +E Q           K D++  +L + L R+     + EA   E    
Sbjct: 2122 LEALPHSHKTSPMEEQSL---------KLDSLEPRLQRELERLQAALRQTEAREIE---- 2168

Query: 260  LQEEHQAAELTRSKQQETVTRLEQ-SLSEAMEALNREQESARLQQR---ERETLEEER-- 313
             +E+ Q   L+ ++ + +V+ L++ ++      L R+ E  RLQ      R  LE+ER  
Sbjct: 2169 WREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLH 2228

Query: 314  ---QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE---H 367
                  T  L +  ++   L E      A    +  E ++ R  LE  +Q  A+ E    
Sbjct: 2229 SPGATSTAELGSRGEQGVQLGEV-SGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS 2287

Query: 368  QLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427
            +L+ H   L+   + Q+ERE+ K +REA  A +          E+ +      T +  R 
Sbjct: 2288 RLQRHNVQLRSTLE-QVERERRKLKREAMRAAQAG------SLEISKATASSPTQQDGRG 2340

Query: 428  ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
                +   V A  + + + L+++L ++ +Q+       AQ S  R+ A L  HH
Sbjct: 2341 QKNSDAKCV-AELQKEVVLLQAQLTLERKQKQDYITRSAQTS--RELAGL--HH 2389


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 86/389 (22%), Positives = 178/389 (45%), Gaps = 34/389 (8%)

Query: 205 QSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEH 264
           + L+ +  ELQ++L +  +   +    ++ L + L            ER ++L   Q+  
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL------------ERAQLLLPQQQLQ 261

Query: 265 QAAELTRSKQQETVTRLEQSL--SEAMEALNREQESARLQQRERETLEEER---QALTLR 319
             A+    + Q    +L+  +  +E    LN++QE    +Q E+   +EE+   Q L +R
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321

Query: 320 LEAE----QQRCCVLQEERDAARAGQL--SEHRELETLRAALEEERQTWAQQE--HQLKE 371
            + E    Q+     QEE+   +  ++   E +  E      E+E + W Q+E   +  E
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE 381

Query: 372 HYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQL 431
             Q  +EE   Q E+ +E+ ++  +  W  + ++     ++R  E E+   R+E    +L
Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM--WRQEEKIREL 439

Query: 432 EMSL----VQARYESQRIQLESELAVQLE---QRVTERLAQAQESSLRQAASLREHHRKQ 484
           E  +     + R   +++Q E E   + E   QR  E++ + +E + RQ   L++  +  
Sbjct: 440 EEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499

Query: 485 LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
            Q+     Q+E   +  +   E  E+ +RQ++   + E+RL +++ ++ E +   Q+LEE
Sbjct: 500 EQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEE 559

Query: 545 QRVELVERLQAMLQAHWDEANQLLSTTLP 573
           +  +L ++ + +  A  +  +Q L T  P
Sbjct: 560 RLGKLGQKAELLGGAGRESGSQRLPTLTP 588



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 58/295 (19%), Positives = 138/295 (46%), Gaps = 25/295 (8%)

Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260
           E  I+  + ++ E ++++       R++D  I++ ++ + R  E     E +R E +   
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411

Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320
           +++ +  +    +Q+E + R E+ + E  E +  ++E  R  + + +  EE+ Q    ++
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471

Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEES 380
           + ++++  + ++E    R  +L +  E        E+E + W +QE ++ E  + +QE+ 
Sbjct: 472 QRQEEK--IQEQEEKTWRQEKLLKQEE-----KIWEQEEKMW-RQEEKMWEQEEKMQEQE 523

Query: 381 QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY 440
           + +++R++EK + +    W+ + ++   +  ++ LE  L    ++ + L           
Sbjct: 524 E-KMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELL----GGAGRES 578

Query: 441 ESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQ 494
            SQR+  L   L V+L+ +  + L Q Q           +H+R  LQ     +QQ
Sbjct: 579 GSQRLPTLTPILQVELKSQEAQSLQQQQ-----------DHYRGHLQQYVAAYQQ 622



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 74/316 (23%), Positives = 146/316 (46%), Gaps = 40/316 (12%)

Query: 226 RKKDTMIEQLDKTLARVVEGWNRHEA--ERTEVLRGLQEE----HQAAELTRSKQQETVT 279
           R+++ + EQ +K   +  + W + E   E+ E ++  +EE     +       K+QE + 
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409

Query: 280 RLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARA 339
           R E+ + E  E +  ++E    Q+ +   LEE  Q    +L   +++   +QEE +  + 
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK---MQEEEEKMQE 466

Query: 340 GQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAW 399
            +    R+ E ++   E+E +TW +QE  LK      QEE   ++  ++EK  R+ +  W
Sbjct: 467 QEEKIQRQEEKIQ---EQEEKTW-RQEKLLK------QEE---KIWEQEEKMWRQEEKMW 513

Query: 400 ETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRV 459
           E + ++   + +++R E ++    RE+   ++ +   + + + Q ++L         Q +
Sbjct: 514 EQEEKMQEQEEKMQRQEEKM----REQ---EVRLWQQEEKMQEQEVRL---------QEL 557

Query: 460 TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE--REERQQQV 517
            ERL +  + +     + RE   ++L  L+   Q EL SQ AQ   +  +  R   QQ V
Sbjct: 558 EERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYV 617

Query: 518 AEDYELRLAREQARVC 533
           A   +L   +E    C
Sbjct: 618 AAYQQLASGKEALPSC 633


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 120/504 (23%), Positives = 202/504 (40%), Gaps = 52/504 (10%)

Query: 67  GLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGA 126
           GL   A+E    L+  L++  +   G +H  ++E +   L+   Q  ++ A         
Sbjct: 523 GLKQQAKEKQAQLAQTLQQQEQASQGLRH--QVEQLSSSLKQKEQQLKEVA--------- 571

Query: 127 GSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGL 186
                ++++   D    L      ++ S      AL++L            +     Q  
Sbjct: 572 ----EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627

Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
            +A DS  T     +R    L  +V ELQ  +  A     +    + +L+  L       
Sbjct: 628 NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL------- 680

Query: 247 NRHEAERTEVLRGLQEEHQAAE-LTRSKQQETVTR--LEQSLSEAMEALNREQESARLQQ 303
              + + TE  R  QE+ Q  E L   K+   VT+  LE+    A +AL  +Q      +
Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740

Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
            E  +L E+ +     LE E+     L+     AR  QL E  + ET    L  E     
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLE-----ARLQQLGEAHQAET--EVLRRELAEAM 793

Query: 364 QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423
             +H  +   + L +E  A  ER ++  Q EAQ         A+ Q ++  L+ E + AR
Sbjct: 794 AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG-------AMFQEQLMTLKEECEKAR 846

Query: 424 RERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK 483
           +E    + +++ +++  E Q  + ++ELA +L   +   L Q QE  +R         +K
Sbjct: 847 QELQEAKEKVAGIESHSELQISRQQNELA-ELHANLARALQQVQEKEVRA--------QK 897

Query: 484 QLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLE 543
              DLS   ++  A+     ++E   R+  +QQ  E     L +E AR  + Q   + LE
Sbjct: 898 LADDLSTLQEKMAATSKEVARLETLVRKAGEQQ--ETASRELVKEPARAGDRQP--EWLE 953

Query: 544 EQRVELVERLQAMLQAHWDEANQL 567
           EQ+       QA LQA   EA Q+
Sbjct: 954 EQQGRQFCSTQAALQAMEREAEQM 977



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 100/418 (23%), Positives = 186/418 (44%), Gaps = 70/418 (16%)

Query: 201  ERHIQSLQTRVLELQ---QQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVL 257
            E  +  L  +VLE +   ++L   V A+ +K   +E+  + L       +   AER+  L
Sbjct: 1231 EEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL 1290

Query: 258  R----GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313
            R     L+EE +   +     ++ +T   +   E  + L   QE    +++   TL+ E 
Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350

Query: 314  ---QALTLRLEAEQQRCCVLQEERDAA------------------RAGQLSEHREL---- 348
               QAL   L   +  C  LQ E+ AA                  RA  L   REL    
Sbjct: 1351 TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELI 1410

Query: 349  ---------ETLRAALEEERQTWAQQEHQLKEHYQALQEES--------------QAQLE 385
                     E     L  E+ ++A+Q   LK+ +  L EE+              + +L+
Sbjct: 1411 PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD 1470

Query: 386  REKEKSQREAQAAW-ETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQR 444
            + +EK  +E  A   + + +LA VQ E +    EL+    + +  ++++   + R++ +R
Sbjct: 1471 QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530

Query: 445  IQLESELAVQLEQRVTERLAQAQESSLR-----QAASLREHHRKQLQDLSGQHQQE---L 496
             +L +++  QLE    E+  Q +E S +     QA+ +++   K +Q   G+ QQE   L
Sbjct: 1531 QKLTAQVE-QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRL 1589

Query: 497  ASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
             +QL + + +++++E    Q AE Y+L++ + +      +  NQ+L+EQ +  +E+LQ
Sbjct: 1590 QAQLNELQAQLSQKE----QAAEHYKLQMEKAKTHYDAKKQQNQELQEQ-LRSLEQLQ 1642



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 95/431 (22%), Positives = 174/431 (40%), Gaps = 32/431 (7%)

Query: 150 LQDLSPSSSAQALEELFPRYTSLRPGPPL--NPPDFQGLRDALDSEH--------TRRKH 199
           LQD  P    + L ++    T  +    L  N    Q   + L++E           R H
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456

Query: 200 CERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRG 259
            E   Q L + + +LQ                I  L +    + +    H A  T  +  
Sbjct: 457 FEEEKQQLSSLITDLQSS--------------ISNLSQAKEELEQASQAHGARLTAQVAS 502

Query: 260 LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLR 319
           L  E      T  +Q + +  L+Q   E    L    ++ + Q++  + L  + + L+  
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQL---AQTLQQQEQASQGLRHQVEQLSSS 559

Query: 320 LEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379
           L+ ++Q+   + E+++A R     +       R A   ER    +Q   L++   A  E 
Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619

Query: 380 SQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQAR 439
            Q QL+   E       +  + Q + A +  +V  L+  ++TAR+E+   Q +++ ++ +
Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679

Query: 440 YES-QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELAS 498
             S Q+   E E   Q + ++ E+L   +ES      SL E  R+    L  + QQ   S
Sbjct: 680 LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL--EEQQRCIS 737

Query: 499 QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ-QLEEQRVELVERLQAML 557
           +L      + E+ +R+++  E+        +AR+ +L   +Q + E  R EL E + A  
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797

Query: 558 QAHWDEANQLL 568
            A   E  QL+
Sbjct: 798 TAE-SECEQLV 807



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 98/412 (23%), Positives = 177/412 (42%), Gaps = 37/412 (8%)

Query: 177 PLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAAD-------RKKD 229
           PL P + + LRD  +S   R     +  Q L+T   ++ +++      +       R+  
Sbjct: 272 PLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFA 331

Query: 230 TMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAM 289
           + ++QL   L  + E  ++   E  E    L++E  AA   +   +E    L+  LS+  
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391

Query: 290 EALNREQESARLQQRE-------RETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQL 342
           E L++ Q++   ++ E        ETL++E   L       Q R  +L+ ER    A  L
Sbjct: 392 EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLL 451

Query: 343 SEHRELETLRAALEEERQTWA----QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAA 398
           +E       R   EEE+Q  +      +  +    QA +E  QA        + + A   
Sbjct: 452 AE-------RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504

Query: 399 WETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQR 458
            E     A +Q + + L G L    +E+ A QL  +L Q    SQ ++ + E   QL   
Sbjct: 505 SELTTLNATIQQQDQELAG-LKQQAKEKQA-QLAQTLQQQEQASQGLRHQVE---QLSSS 559

Query: 459 VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK-VEMAEREERQQQV 517
           + ++  Q +E + +Q A+ R+ H +QL   + + +  L  + A  K +E  E+E+  +  
Sbjct: 560 LKQKEQQLKEVAEKQEAT-RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618

Query: 518 AEDYELRLAREQARVCELQSGNQQLEEQRVEL---VERLQAMLQAHWDEANQ 566
               +L++A E       Q+   Q + ++ EL   VE LQA ++    E ++
Sbjct: 619 ILQQQLQVANEARD--SAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 140/575 (24%), Positives = 233/575 (40%), Gaps = 99/575 (17%)

Query: 49   EATARAQLYLPSTSPPHEGLDGFA---QELSRSLSV--GLEKNLKKKDG--SKHIFEMES 101
            E  ARA+L +   +  +E    FA   + L+ +L+   G ++ L K  G  +  I E+E 
Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE 1082

Query: 102  VRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQA 161
            +R   QT+ Q     A ++          +E  S     +     T P        +   
Sbjct: 1083 LR---QTVKQLKEQLAKKE----------KEHASGSGAQSEAAGRTEP--------TGPK 1121

Query: 162  LEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVA 221
            LE L    + L             L  +L++E   R   +  +++LQ ++ E  Q+L  +
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181

Query: 222  ----------VAADRKK-DTMIEQLDKTLARVVEGWNRHEAERTEVL------------- 257
                      +AA R K     +  D+  A+V  G  R EAER   L             
Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARG--RQEAERKNSLISSLEEEVSILNR 1239

Query: 258  RGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET-LEEERQAL 316
            + L++E ++ EL R    E+     Q L E +  L  E  S   +  ER + L EE Q+L
Sbjct: 1240 QVLEKEGESKELKRLVMAES--EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297

Query: 317  TLRLEAEQQRCCV--LQEE--RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ---- 368
              R EAE+QR     L++E    A RA +L +  +    +   +E+  +  Q EH     
Sbjct: 1298 --REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355

Query: 369  -------LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGEL-- 419
                    K   Q LQ E  A  +R +E+ ++  QAA   + +L   Q E+    GEL  
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL----GELIP 1411

Query: 420  ---DTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAAS 476
                 A +ER A QL     +A Y  Q   L+    +  E+             L + A+
Sbjct: 1412 LRQKVAEQERTAQQLRAE--KASYAEQLSMLKKAHGLLAEEN----------RGLGERAN 1459

Query: 477  L-REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
            L R+    +L     ++ QELA+  A  +  +AE +   Q  A + E+  A+ +    ++
Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519

Query: 536  QSGNQQLEEQRVEL---VERLQAMLQAHWDEANQL 567
                Q+ +E+R +L   VE+L+   +    +  +L
Sbjct: 1520 LEERQRFQEERQKLTAQVEQLEVFQREQTKQVEEL 1554



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 81/340 (23%), Positives = 149/340 (43%), Gaps = 57/340 (16%)

Query: 274 QQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEE 333
           +++    + Q   + +  LN +Q ++ L+ +E E L ++ ++LT+RL    ++C  L+ E
Sbjct: 246 EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTE 305

Query: 334 RDA--ARAGQLSEHR-ELE-TLRAALEEERQTWAQQEHQLKEHYQALQE--ESQAQLERE 387
           +     +  QLSE   +L   LR      +Q         +EH +A QE  E QAQLE+E
Sbjct: 306 KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365

Query: 388 -----------KEKSQREAQAAWETQHQLALVQSEVRRLEGE-------LDTARRERDAL 429
                      +EK++       + +  L+ +Q    + +GE       L+T ++E   L
Sbjct: 366 LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATL 425

Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE--------SSLRQAASLREHH 481
               + +QAR E     LE+E   Q  + + ER    +E        + L+ + S     
Sbjct: 426 AANNTQLQARVE----MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQA 481

Query: 482 RKQLQDLSGQHQQELASQLAQFKVEMA------------------EREERQQQVAEDYEL 523
           +++L+  S  H   L +Q+A    E+                   + +E+Q Q+A+  + 
Sbjct: 482 KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541

Query: 524 RLAREQA---RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
           +    Q    +V +L S  +Q E+Q  E+ E+ +A  Q H
Sbjct: 542 QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH 581



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 135/581 (23%), Positives = 235/581 (40%), Gaps = 89/581 (15%)

Query: 39   YASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFE 98
            ++ L++SRQ    A     L       +  +  AQ+L+  LS   EK       SK +  
Sbjct: 862  HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT---SKEVAR 918

Query: 99   MESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSS 158
            +E++  +     +T+     ++P   G   +R+ E          L   +  Q  S  ++
Sbjct: 919  LETLVRKAGEQQETASRELVKEPARAG---DRQPE---------WLEEQQGRQFCSTQAA 966

Query: 159  AQALEELFPRYTSLRPGPPLNPPDFQGLRDAL----DSEHTRRKHCERHIQSLQTRVLEL 214
             QA+E    +  +          + + LR AL      +   R   ER +  L       
Sbjct: 967  LQAMEREAEQMGN----------ELERLRAALMESQGQQQEERGQQEREVARLTQERGRA 1016

Query: 215  QQQLAVAVAAD-----RKKDTMIEQ------LDKTLARVVEGWNRHEAERTEVLRGLQEE 263
            Q  LA+  AA      R ++ + EQ      L + LA  +      + E  + LRGL E 
Sbjct: 1017 QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK-LRGL-EA 1074

Query: 264  HQAAELTRSKQQETVTRLEQSLS----EAMEALNREQESARLQQR---ERETLEEERQAL 316
             Q  EL   +Q  TV +L++ L+    E       + E+A   +    + E L  E   L
Sbjct: 1075 AQIKELEELRQ--TVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132

Query: 317  TLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ---------TWAQQE- 366
              + + +Q++   L+   +A RA +      LETL+  LEE+ Q           AQ+E 
Sbjct: 1133 EQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL 1192

Query: 367  ----HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTA 422
                 ++++H +A ++E +AQ+ R +++++R+       + +++++  +V   EGE    
Sbjct: 1193 AAFRTKVQDHSKA-EDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251

Query: 423  RRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR-QAASLREHH 481
            +R          LV A  E  +   E    +Q E       A  + S+LR +  SLRE  
Sbjct: 1252 KR----------LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA 1301

Query: 482  RKQ-------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCE 534
             KQ        Q+L+   Q E A +L Q      E+  +++Q     +L     QA V E
Sbjct: 1302 EKQRVASENLRQELTS--QAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSE 1359

Query: 535  LQSGN---QQLEEQRVELVERLQAMLQAHWDEANQLLSTTL 572
            L       QQL+ ++    +R +  L+     A  L +  L
Sbjct: 1360 LLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 47/186 (25%), Positives = 88/186 (47%), Gaps = 33/186 (17%)

Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE 468
           Q ++RRL+ +L   R  RD L+LE++      E++++  E +  + + Q+  +RLA   E
Sbjct: 213 QFQMRRLKKQLADERSNRDELELELA------ENRKLLTEKDAQIAMMQQRIDRLALLNE 266

Query: 469 SSLRQAASLREHHRKQLQDLSGQHQ------QELASQLAQFKVEMAEREERQQQVAE--- 519
              +QAAS  E   K+L++L  +++       E   Q    K E ++ + +  Q++E   
Sbjct: 267 ---KQAASPLE--PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321

Query: 520 DYELRLAREQARVCELQSGNQQLEEQ-----------RVELVERLQAMLQAH--WDEANQ 566
           D   +L    + + +LQ    +L E+           + +L + L A LQ     +E N+
Sbjct: 322 DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381

Query: 567 LLSTTL 572
           +L   L
Sbjct: 382 ILQGKL 387



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 57/278 (20%), Positives = 122/278 (43%), Gaps = 62/278 (22%)

Query: 201  ERHIQSL-------QTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253
            E+++Q L       +TR+ E+Q++   A +  R+ + M  + +    +V+E   R + ER
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQRE---AQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530

Query: 254  TEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313
             ++   +++     E+ + +Q + V  L + L+++ +A   +Q+  +  Q +    ++E 
Sbjct: 1531 QKLTAQVEQ----LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEA 1586

Query: 314  QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHY 373
            Q L  +L   Q +   L ++  AA      EH +L+  +A                K HY
Sbjct: 1587 QRLQAQLNELQAQ---LSQKEQAA------EHYKLQMEKA----------------KTHY 1621

Query: 374  QALQEESQ---------AQLEREKEKSQREAQAAWETQHQLAL-----------VQSEVR 413
             A ++++Q          QL++E ++ + EA+       Q  L           + ++VR
Sbjct: 1622 DAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVR 1681

Query: 414  RLEGEL---DTARRERDALQLEMSLVQARYESQRIQLE 448
             LE ++   D   R+    Q+    +++R    + QL+
Sbjct: 1682 SLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%)

Query: 141  TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
            T  LL     Q L+ S+  + LEE                 +   L+D LD E   +++ 
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1362

Query: 201  ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228
            ERHI +L                            Q  +  L QQ     AA    ++ K
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422

Query: 229  DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275
            + + ++LD               L +    +++  AE   +     +E   AE    +++
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 276  ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321
                 L ++L EA+EA    + + ++ + E E L              E+ ++AL  ++E
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 322  AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381
              + +   L++E  A    +L     ++ L+   E + Q   +Q  + +   Q    E +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602

Query: 382  AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420
             +LE E+++    A A                       E   QL  +Q++++  + EL+
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 421  TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472
             AR  RD   A   E        E+  +QL+ +LA     R       E LA+   SSL 
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 473  QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
               +L++  R+ L+    Q ++EL  +    +  M++R  +  Q AE     LA E++  
Sbjct: 1723 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1780

Query: 533  CELQSGNQQLEEQRVELVERLQAM 556
             + +S  QQLE Q  EL  +L  M
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEM 1804



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251
            R   E   +  +T+ L L + L  A+ A  + +   + L   +  +V      G N HE 
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530

Query: 252  ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299
            E+++             L  L++E QA E  + + +  +  L+      ++A + + E  
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590

Query: 300  RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340
            R Q +    E ET LE+ER+   L   A+++    L++   + D+A  G           
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650

Query: 341  --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394
              Q+ +  RELE  RA+ +E   T  + E + K        LQE+  A     K+    +
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710

Query: 395  AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
             + A E    L+    +Q E RRLE  +     E +  Q  M  +     S R++  ++ 
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1765

Query: 452  AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
            A QL   + TER  AQ  ES+ +Q     +  R +L ++ G  + +  S +A  + ++A+
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825

Query: 510  REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
             EE+ +Q A +       +QA    L+  +++L+E  ++ VE  + M + + ++A +
Sbjct: 1826 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1874



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%)

Query: 182  DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            + Q     LD E  ++ +  + I+ L+  + +LQ+ L    AA  K +     L + L  
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1148

Query: 242  VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
                    EA +TE+   L       EL R+K+++ VT L+++L E  E  + E +   +
Sbjct: 1149 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1197

Query: 302  QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
            +Q+  + +EE  + L               E+   A+A      + LE   A L  E + 
Sbjct: 1198 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1242

Query: 362  WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
              Q + +++   + L+    AQ++  + K     +A  E   ++  +Q+EV  + G L+ 
Sbjct: 1243 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298

Query: 422  ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
            A  +   L  +++ + ++ +  +  L+ E   +L   V+ +L Q +E             
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1344

Query: 482  RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
            R  LQD   +    +Q L   ++   +++++ +++ Q  A   E     ++    E+++ 
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404

Query: 539  NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585
             QQ EE+    + +E+ +  LQ   D+         QL+S             A     S
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464

Query: 586  SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637
            S    E ++ E         A++L   L+++ EA++EL     +L +   DL
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L+ E  R +  +   + +  ++L+L++QL    AA +K      QL+K  A         
Sbjct: 931  LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 976

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            EA+    ++ L++E    +   +K  +    LE+ +S+    L  E+E A+   + +   
Sbjct: 977  EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
            E     L +RL+ E++    L++ +          H ++  L+A + E +   A++E   
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1089

Query: 370  KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429
                    EE QA L R  ++  ++  A      ++  ++  +  L+ +LD+ R  R+  
Sbjct: 1090 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1137

Query: 430  QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488
            + +   +    E+ + +LE  L     Q+      + + + L++A       H  Q+Q++
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197

Query: 489  SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528
              +H Q   EL  QL QFK   A  ++ +Q                 Q  ++ E +  + 
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257

Query: 529  QARVCELQSGNQQLEEQRVELVERLQAM 556
            +A+V ELQS     E  R EL +++  +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKL 1285



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%)

Query: 272  SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331
            ++Q+E +   E  L +  E   + +   +  +++   L EE+  L  +L+AE +     +
Sbjct: 848  TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907

Query: 332  EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391
            E R    A +      L  + A LEEE     Q + + K       + +Q  L+ E++  
Sbjct: 908  EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 960

Query: 392  QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449
            + EA A  + Q +    ++++++LE E+     + + L  E  L++ R       L  E 
Sbjct: 961  EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019

Query: 450  ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501
            E A  L +   +  +   E  +R          L +  RK   D S  H+Q  +L +Q+A
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079

Query: 502  QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544
            + K+++A++EE  Q      +  +A++          +  + +LQ       +   + E+
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139

Query: 545  QRVELVERLQAM 556
            Q+ +L E L+A+
Sbjct: 1140 QKRDLGEELEAL 1151



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 111/537 (20%), Positives = 222/537 (41%), Gaps = 79/537 (14%)

Query: 36   SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92
            S  YA  R   +AEA  +    L       E L+   +EL R+   L   +E  +  KD 
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1522

Query: 93   -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
              K++ E+E  +  L+T ++  +              E  +E     D+   L       
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1565

Query: 152  DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211
                  + QAL+  F R             D Q  RD  + E  +R+  +R +   +T +
Sbjct: 1566 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1605

Query: 212  LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266
             + ++Q A+A AA +K +  ++ L+      ++G  R EA +        ++  Q E + 
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1663

Query: 267  AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            A  +R +   T    E+        L + QE     +R R+  + E++ L   L +    
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 327  CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377
               LQ+E  R  AR  QL E  E     +E +   + +  Q   Q  ++L       Q  
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 378  EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432
            E ++ QLER+ ++ +    E + A +++ +  +A +++++ +LE +++   RE+ A    
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 433  MSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQH 492
            +     + +   +Q+E       E+++ E+  +  E    +   L    ++QL++ + + 
Sbjct: 1844 LKQKDKKLKEILLQVED------ERKMAEQYKEQAEKGNARVKQL----KRQLEE-AEEE 1892

Query: 493  QQELASQLAQFKVEMAEREERQQQVAEDY-----ELRLAREQARVCELQSGNQQLEE 544
             Q + +   + + E+ E  E  + +  +      +LR   E + V   +SG +++ E
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%)

Query: 270  TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
            T+ K    VTR E+ +    + L + +E  +  + E + LE++   LT            
Sbjct: 839  TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 886

Query: 330  LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
              EE++      L E  + ET L A  EE R   A ++ +L+E    +  E +A+LE E+
Sbjct: 887  --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 935

Query: 389  EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448
            ++ Q       + Q +   +  ++  LE +L+     R  LQLE    +A+ +    +LE
Sbjct: 936  DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 984

Query: 449  SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
             E+ V  +Q        +L + + S L    +  E   K L  L  +H+    S +++ +
Sbjct: 985  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1040

Query: 505  VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
            V + ++EE+ +Q  E  + +L  + +    ++ +LQ+   +L+ Q  +  E LQA L   
Sbjct: 1041 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 561  WDEANQ 566
             DE  Q
Sbjct: 1100 DDEIAQ 1105



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%)

Query: 255  EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304
            E ++  ++E Q  +  + K +  +  LEQ  S+  E  N  QE  + +            
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911

Query: 305  ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354
                +++ LEE    +  RLE E+ R   LQ ER       L    +LE   AA      
Sbjct: 912  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971

Query: 355  -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400
                       LE+E      Q ++L +  + L+E   +    L  E+EK++   +   +
Sbjct: 972  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1029

Query: 401  TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
             +H+  + + EVR     +   EL+  +R+ +    +     A  ++Q  +L+ +LA + 
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 456  EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500
            E+      R+ + +AQ + ++L++   L  H     +DL  +          +++L  +L
Sbjct: 1090 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148

Query: 501  AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560
               K E+   E+     A   ELR  REQ    E+    + L+E+      ++Q M Q H
Sbjct: 1149 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 561  WDEANQL 567
                 +L
Sbjct: 1202 AQAVEEL 1208



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%)

Query: 344  EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403
            +  E++     L++ ++   + E++LKE      E+  +QL  EK   Q + QA  E   
Sbjct: 850  QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 901

Query: 404  QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463
                + +E   +   L   ++E + +  EM       E +  QL++E     +Q +    
Sbjct: 902  ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 464  AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509
               +E + RQ   L     E   K+L+D             + ++ L  +++     +AE
Sbjct: 958  QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017

Query: 510  REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
             EE          + + +  + E+RL +E+    EL+   ++LE    +  E++ A LQA
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1076

Query: 560  HWDEANQLLS 569
               E    L+
Sbjct: 1077 QIAELKMQLA 1086


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%)

Query: 141  TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
            T  LL     Q L+ S+  + LEE                 +   L+D LD E   +++ 
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1369

Query: 201  ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228
            ERHI +L                            Q  +  L QQ     AA    ++ K
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429

Query: 229  DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275
            + + ++LD               L +    +++  AE   +     +E   AE    +++
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 276  ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321
                 L ++L EA+EA    + + ++ + E E L              E+ ++AL  ++E
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 322  AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381
              + +   L++E  A    +L     ++ L+   E + Q   +Q  + +   Q    E +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609

Query: 382  AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420
             +LE E+++    A A                       E   QL  +Q++++  + EL+
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 421  TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472
             AR  RD   A   E        E+  +QL+ +LA     R       E LA+   SSL 
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 473  QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
               +L++  R+ L+    Q ++EL  +    +  M++R  +  Q AE     LA E++  
Sbjct: 1730 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1787

Query: 533  CELQSGNQQLEEQRVELVERLQAM 556
             + +S  QQLE Q  EL  +L  M
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEM 1811



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251
            R   E   +  +T+ L L + L  A+ A  + +   + L   +  +V      G N HE 
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537

Query: 252  ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299
            E+++             L  L++E QA E  + + +  +  L+      ++A + + E  
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597

Query: 300  RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340
            R Q +    E ET LE+ER+   L   A+++    L++   + D+A  G           
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657

Query: 341  --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394
              Q+ +  RELE  RA+ +E   T  + E + K        LQE+  A     K+    +
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717

Query: 395  AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
             + A E    L+    +Q E RRLE  +     E +  Q  M  +     S R++  ++ 
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1772

Query: 452  AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
            A QL   + TER  AQ  ES+ +Q     +  R +L ++ G  + +  S +A  + ++A+
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832

Query: 510  REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
             EE+ +Q A +       +QA    L+  +++L+E  ++ VE  + M + + ++A +
Sbjct: 1833 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1881



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%)

Query: 182  DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            + Q     LD E  ++ +  + I+ L+  + +LQ+ L    AA  K +     L + L  
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1155

Query: 242  VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
                    EA +TE+   L       EL R+K+++ VT L+++L E  E  + E +   +
Sbjct: 1156 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1204

Query: 302  QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
            +Q+  + +EE  + L               E+   A+A      + LE   A L  E + 
Sbjct: 1205 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1249

Query: 362  WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
              Q + +++   + L+    AQ++  + K     +A  E   ++  +Q+EV  + G L+ 
Sbjct: 1250 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305

Query: 422  ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
            A  +   L  +++ + ++ +  +  L+ E   +L   V+ +L Q +E             
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1351

Query: 482  RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
            R  LQD   +    +Q L   ++   +++++ +++ Q  A   E     ++    E+++ 
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411

Query: 539  NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585
             QQ EE+    + +E+ +  LQ   D+         QL+S             A     S
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471

Query: 586  SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637
            S    E ++ E         A++L   L+++ EA++EL     +L +   DL
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L+ E  R +  +   + +  ++L+L++QL    AA +K      QL+K  A         
Sbjct: 938  LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 983

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            EA+    ++ L++E    +   +K  +    LE+ +S+    L  E+E A+   + +   
Sbjct: 984  EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
            E     L +RL+ E++    L++ +          H ++  L+A + E +   A++E   
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1096

Query: 370  KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429
                    EE QA L R  ++  ++  A      ++  ++  +  L+ +LD+ R  R+  
Sbjct: 1097 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1144

Query: 430  QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488
            + +   +    E+ + +LE  L     Q+      + + + L++A       H  Q+Q++
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204

Query: 489  SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528
              +H Q   EL  QL QFK   A  ++ +Q                 Q  ++ E +  + 
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264

Query: 529  QARVCELQSGNQQLEEQRVELVERLQAM 556
            +A+V ELQS     E  R EL +++  +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKL 1292



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%)

Query: 272  SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331
            ++Q+E +   E  L +  E   + +   +  +++   L EE+  L  +L+AE +     +
Sbjct: 855  TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914

Query: 332  EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391
            E R    A +      L  + A LEEE     Q + + K       + +Q  L+ E++  
Sbjct: 915  EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 967

Query: 392  QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449
            + EA A  + Q +    ++++++LE E+     + + L  E  L++ R       L  E 
Sbjct: 968  EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026

Query: 450  ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501
            E A  L +   +  +   E  +R          L +  RK   D S  H+Q  +L +Q+A
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086

Query: 502  QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544
            + K+++A++EE  Q      +  +A++          +  + +LQ       +   + E+
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

Query: 545  QRVELVERLQAM 556
            Q+ +L E L+A+
Sbjct: 1147 QKRDLGEELEAL 1158



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 111/537 (20%), Positives = 222/537 (41%), Gaps = 79/537 (14%)

Query: 36   SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92
            S  YA  R   +AEA  +    L       E L+   +EL R+   L   +E  +  KD 
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1529

Query: 93   -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
              K++ E+E  +  L+T ++  +              E  +E     D+   L       
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1572

Query: 152  DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211
                  + QAL+  F R             D Q  RD  + E  +R+  +R +   +T +
Sbjct: 1573 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1612

Query: 212  LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266
             + ++Q A+A AA +K +  ++ L+      ++G  R EA +        ++  Q E + 
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1670

Query: 267  AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            A  +R +   T    E+        L + QE     +R R+  + E++ L   L +    
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 327  CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377
               LQ+E  R  AR  QL E  E     +E +   + +  Q   Q  ++L       Q  
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 378  EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432
            E ++ QLER+ ++ +    E + A +++ +  +A +++++ +LE +++   RE+ A    
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 433  MSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQH 492
            +     + +   +Q+E       E+++ E+  +  E    +   L    ++QL++ + + 
Sbjct: 1851 LKQKDKKLKEILLQVED------ERKMAEQYKEQAEKGNARVKQL----KRQLEE-AEEE 1899

Query: 493  QQELASQLAQFKVEMAEREERQQQVAEDY-----ELRLAREQARVCELQSGNQQLEE 544
             Q + +   + + E+ E  E  + +  +      +LR   E + V   +SG +++ E
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%)

Query: 270  TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
            T+ K    VTR E+ +    + L + +E  +  + E + LE++   LT            
Sbjct: 846  TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 893

Query: 330  LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
              EE++      L E  + ET L A  EE R   A ++ +L+E    +  E +A+LE E+
Sbjct: 894  --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 942

Query: 389  EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448
            ++ Q       + Q +   +  ++  LE +L+     R  LQLE    +A+ +    +LE
Sbjct: 943  DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 991

Query: 449  SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
             E+ V  +Q        +L + + S L    +  E   K L  L  +H+    S +++ +
Sbjct: 992  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1047

Query: 505  VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
            V + ++EE+ +Q  E  + +L  + +    ++ +LQ+   +L+ Q  +  E LQA L   
Sbjct: 1048 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 561  WDEANQ 566
             DE  Q
Sbjct: 1107 DDEIAQ 1112



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%)

Query: 255  EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304
            E ++  ++E Q  +  + K +  +  LEQ  S+  E  N  QE  + +            
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918

Query: 305  ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354
                +++ LEE    +  RLE E+ R   LQ ER       L    +LE   AA      
Sbjct: 919  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978

Query: 355  -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400
                       LE+E      Q ++L +  + L+E   +    L  E+EK++   +   +
Sbjct: 979  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1036

Query: 401  TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
             +H+  + + EVR     +   EL+  +R+ +    +     A  ++Q  +L+ +LA + 
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 456  EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500
            E+      R+ + +AQ + ++L++   L  H     +DL  +          +++L  +L
Sbjct: 1097 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155

Query: 501  AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560
               K E+   E+     A   ELR  REQ    E+    + L+E+      ++Q M Q H
Sbjct: 1156 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 561  WDEANQL 567
                 +L
Sbjct: 1209 AQAVEEL 1215



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%)

Query: 344  EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403
            +  E++     L++ ++   + E++LKE      E+  +QL  EK   Q + QA  E   
Sbjct: 857  QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 908

Query: 404  QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463
                + +E   +   L   ++E + +  EM       E +  QL++E     +Q +    
Sbjct: 909  ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 464  AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509
               +E + RQ   L     E   K+L+D             + ++ L  +++     +AE
Sbjct: 965  QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024

Query: 510  REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
             EE          + + +  + E+RL +E+    EL+   ++LE    +  E++ A LQA
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1083

Query: 560  HWDEANQLLS 569
               E    L+
Sbjct: 1084 QIAELKMQLA 1093


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%)

Query: 141  TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
            T  LL     Q L+ S+  + LEE                 +   L+D LD E   +++ 
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1369

Query: 201  ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228
            ERHI +L                            Q  +  L QQ     AA    ++ K
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429

Query: 229  DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275
            + + ++LD               L +    +++  AE   +     +E   AE    +++
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 276  ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321
                 L ++L EA+EA    + + ++ + E E L              E+ ++AL  ++E
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 322  AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381
              + +   L++E  A    +L     ++ L+   E + Q   +Q  + +   Q    E +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609

Query: 382  AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420
             +LE E+++    A A                       E   QL  +Q++++  + EL+
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 421  TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472
             AR  RD   A   E        E+  +QL+ +LA     R       E LA+   SSL 
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 473  QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
               +L++  R+ L+    Q ++EL  +    +  M++R  +  Q AE     LA E++  
Sbjct: 1730 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1787

Query: 533  CELQSGNQQLEEQRVELVERLQAM 556
             + +S  QQLE Q  EL  +L  M
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEM 1811



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251
            R   E   +  +T+ L L + L  A+ A  + +   + L   +  +V      G N HE 
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537

Query: 252  ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299
            E+++             L  L++E QA E  + + +  +  L+      ++A + + E  
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597

Query: 300  RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340
            R Q +    E ET LE+ER+   L   A+++    L++   + D+A  G           
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657

Query: 341  --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394
              Q+ +  RELE  RA+ +E   T  + E + K        LQE+  A     K+    +
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717

Query: 395  AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
             + A E    L+    +Q E RRLE  +     E +  Q  M  +     S R++  ++ 
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1772

Query: 452  AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
            A QL   + TER  AQ  ES+ +Q     +  R +L ++ G  + +  S +A  + ++A+
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832

Query: 510  REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
             EE+ +Q A +       +QA    L+  +++L+E  ++ VE  + M + + ++A +
Sbjct: 1833 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1881



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 82/391 (20%), Positives = 163/391 (41%), Gaps = 61/391 (15%)

Query: 77   RSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTML---QTSRDTAYRDPLIPGAGSERREE 133
            ++L    E++L+ +D        E  R QLQ  L   +T  +   +   +  A  ++ E 
Sbjct: 1577 QALKGQFERDLQARDEQN-----EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 134  DSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSE 193
            D  D +             L   S+ +  EE   +   L+        + +  R + D  
Sbjct: 1632 DLKDLE-------------LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678

Query: 194  HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253
                K  E+  +SL+  +++LQ+ LA A  A ++ D   E+L + LA  + G N  + E+
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738

Query: 254  TEV---LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLE 310
              +   +  L+EE +  +       + V +  Q   +    L  E+ +A+  +  R+ LE
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798

Query: 311  EERQALTLRLE---------------AEQQRCCVLQE-------ERDAARAGQLSEHREL 348
             + + L  +L                A + +   L+E       E+ AA      + ++L
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858

Query: 349  ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408
            + +   +E+ER+  A+Q  +  E   A  ++ + QLE  +E+SQR              +
Sbjct: 1859 KEILLQVEDERKM-AEQYKEQAEKGNARVKQLKRQLEEAEEESQR--------------I 1903

Query: 409  QSEVRRLEGELDTARRERDALQLEMSLVQAR 439
             +  R+L+ ELD A    +A+  E++ ++++
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSK 1934



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%)

Query: 182  DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            + Q     LD E  ++ +  + I+ L+  + +LQ+ L    AA  K +     L + L  
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1155

Query: 242  VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
                    EA +TE+   L       EL R+K+++ VT L+++L E  E  + E +   +
Sbjct: 1156 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1204

Query: 302  QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
            +Q+  + +EE  + L               E+   A+A      + LE   A L  E + 
Sbjct: 1205 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1249

Query: 362  WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
              Q + +++   + L+    AQ++  + K     +A  E   ++  +Q+EV  + G L+ 
Sbjct: 1250 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305

Query: 422  ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
            A  +   L  +++ + ++ +  +  L+ E   +L   V+ +L Q +E             
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1351

Query: 482  RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
            R  LQD   +    +Q L   ++   +++++ +++ Q  A   E     ++    E+++ 
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411

Query: 539  NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585
             QQ EE+    + +E+ +  LQ   D+         QL+S             A     S
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471

Query: 586  SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637
            S    E ++ E         A++L   L+++ EA++EL     +L +   DL
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L+ E  R +  +   + +  ++L+L++QL    AA +K      QL+K  A         
Sbjct: 938  LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 983

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            EA+    ++ L++E    +   +K  +    LE+ +S+    L  E+E A+   + +   
Sbjct: 984  EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
            E     L +RL+ E++    L++ +          H ++  L+A + E +   A++E   
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1096

Query: 370  KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429
                    EE QA L R  ++  ++  A      ++  ++  +  L+ +LD+ R  R+  
Sbjct: 1097 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1144

Query: 430  QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488
            + +   +    E+ + +LE  L     Q+      + + + L++A       H  Q+Q++
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204

Query: 489  SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528
              +H Q   EL  QL QFK   A  ++ +Q                 Q  ++ E +  + 
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264

Query: 529  QARVCELQSGNQQLEEQRVELVERLQAM 556
            +A+V ELQS     E  R EL +++  +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKL 1292



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%)

Query: 272  SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331
            ++Q+E +   E  L +  E   + +   +  +++   L EE+  L  +L+AE +     +
Sbjct: 855  TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914

Query: 332  EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391
            E R    A +      L  + A LEEE     Q + + K       + +Q  L+ E++  
Sbjct: 915  EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 967

Query: 392  QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449
            + EA A  + Q +    ++++++LE E+     + + L  E  L++ R       L  E 
Sbjct: 968  EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026

Query: 450  ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501
            E A  L +   +  +   E  +R          L +  RK   D S  H+Q  +L +Q+A
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086

Query: 502  QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544
            + K+++A++EE  Q      +  +A++          +  + +LQ       +   + E+
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

Query: 545  QRVELVERLQAM 556
            Q+ +L E L+A+
Sbjct: 1147 QKRDLGEELEAL 1158



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%)

Query: 270  TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
            T+ K    VTR E+ +    + L + +E  +  + E + LE++   LT            
Sbjct: 846  TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 893

Query: 330  LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
              EE++      L E  + ET L A  EE R   A ++ +L+E    +  E +A+LE E+
Sbjct: 894  --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 942

Query: 389  EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448
            ++ Q       + Q +   +  ++  LE +L+     R  LQLE    +A+ +    +LE
Sbjct: 943  DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 991

Query: 449  SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
             E+ V  +Q        +L + + S L    +  E   K L  L  +H+    S +++ +
Sbjct: 992  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1047

Query: 505  VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
            V + ++EE+ +Q  E  + +L  + +    ++ +LQ+   +L+ Q  +  E LQA L   
Sbjct: 1048 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 561  WDEANQ 566
             DE  Q
Sbjct: 1107 DDEIAQ 1112



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 105/483 (21%), Positives = 201/483 (41%), Gaps = 75/483 (15%)

Query: 36   SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92
            S  YA  R   +AEA  +    L       E L+   +EL R+   L   +E  +  KD 
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1529

Query: 93   -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
              K++ E+E  +  L+T ++  +              E  +E     D+   L       
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1572

Query: 152  DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211
                  + QAL+  F R             D Q  RD  + E  +R+  +R +   +T +
Sbjct: 1573 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1612

Query: 212  LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266
             + ++Q A+A AA +K +  ++ L+      ++G  R EA +        ++  Q E + 
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1670

Query: 267  AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            A  +R +   T    E+        L + QE     +R R+  + E++ L   L +    
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 327  CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377
               LQ+E  R  AR  QL E  E     +E +   + +  Q   Q  ++L       Q  
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 378  EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432
            E ++ QLER+ ++ +    E + A +++ +  +A +++++ +LE +++   RE+ A    
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 433  MSLVQARYESQRIQLESE--LAVQLEQ----------RVTERLAQAQESSLRQAASLREH 480
            +     + +   +Q+E E  +A Q ++          ++  +L +A+E S R  A+ R+ 
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910

Query: 481  HRK 483
             R+
Sbjct: 1911 QRE 1913



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%)

Query: 255  EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304
            E ++  ++E Q  +  + K +  +  LEQ  S+  E  N  QE  + +            
Sbjct: 859  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918

Query: 305  ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354
                +++ LEE    +  RLE E+ R   LQ ER       L    +LE   AA      
Sbjct: 919  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978

Query: 355  -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400
                       LE+E      Q ++L +  + L+E   +    L  E+EK++   +   +
Sbjct: 979  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1036

Query: 401  TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
             +H+  + + EVR     +   EL+  +R+ +    +     A  ++Q  +L+ +LA + 
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 456  EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500
            E+      R+ + +AQ + ++L++   L  H     +DL  +          +++L  +L
Sbjct: 1097 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155

Query: 501  AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560
               K E+   E+     A   ELR  REQ    E+    + L+E+      ++Q M Q H
Sbjct: 1156 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 561  WDEANQL 567
                 +L
Sbjct: 1209 AQAVEEL 1215



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%)

Query: 344  EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403
            +  E++     L++ ++   + E++LKE      E+  +QL  EK   Q + QA  E   
Sbjct: 857  QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 908

Query: 404  QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463
                + +E   +   L   ++E + +  EM       E +  QL++E     +Q +    
Sbjct: 909  ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 464  AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509
               +E + RQ   L     E   K+L+D             + ++ L  +++     +AE
Sbjct: 965  QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024

Query: 510  REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
             EE          + + +  + E+RL +E+    EL+   ++LE    +  E++ A LQA
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1083

Query: 560  HWDEANQLLS 569
               E    L+
Sbjct: 1084 QIAELKMQLA 1093


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%)

Query: 141  TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
            T  LL     Q L+ S+  + LEE                 +   L+D LD E   +++ 
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1362

Query: 201  ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228
            ERHI +L                            Q  +  L QQ     AA    ++ K
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422

Query: 229  DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275
            + + ++LD               L +    +++  AE   +     +E   AE    +++
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 276  ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321
                 L ++L EA+EA    + + ++ + E E L              E+ ++AL  ++E
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 322  AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381
              + +   L++E  A    +L     ++ L+   E + Q   +Q  + +   Q    E +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602

Query: 382  AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420
             +LE E+++    A A                       E   QL  +Q++++  + EL+
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 421  TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472
             AR  RD   A   E        E+  +QL+ +LA     R       E LA+   SSL 
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 473  QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
               +L++  R+ L+    Q ++EL  +    +  M++R  +  Q AE     LA E++  
Sbjct: 1723 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1780

Query: 533  CELQSGNQQLEEQRVELVERLQAM 556
             + +S  QQLE Q  EL  +L  M
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEM 1804



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%)

Query: 197  RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251
            R   E   +  +T+ L L + L  A+ A  + +   + L   +  +V      G N HE 
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530

Query: 252  ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299
            E+++             L  L++E QA E  + + +  +  L+      ++A + + E  
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590

Query: 300  RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340
            R Q +    E ET LE+ER+   L   A+++    L++   + D+A  G           
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650

Query: 341  --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394
              Q+ +  RELE  RA+ +E   T  + E + K        LQE+  A     K+    +
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710

Query: 395  AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
             + A E    L+    +Q E RRLE  +     E +  Q  M  +     S R++  ++ 
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1765

Query: 452  AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
            A QL   + TER  AQ  ES+ +Q     +  R +L ++ G  + +  S +A  + ++A+
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825

Query: 510  REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
             EE+ +Q A +       +QA    L+  +++L+E  ++ VE  + M + + ++A +
Sbjct: 1826 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1874



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 82/391 (20%), Positives = 163/391 (41%), Gaps = 61/391 (15%)

Query: 77   RSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTML---QTSRDTAYRDPLIPGAGSERREE 133
            ++L    E++L+ +D        E  R QLQ  L   +T  +   +   +  A  ++ E 
Sbjct: 1570 QALKGQFERDLQARDEQN-----EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 134  DSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSE 193
            D  D +             L   S+ +  EE   +   L+        + +  R + D  
Sbjct: 1625 DLKDLE-------------LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671

Query: 194  HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253
                K  E+  +SL+  +++LQ+ LA A  A ++ D   E+L + LA  + G N  + E+
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731

Query: 254  TEV---LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLE 310
              +   +  L+EE +  +       + V +  Q   +    L  E+ +A+  +  R+ LE
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791

Query: 311  EERQALTLRLE---------------AEQQRCCVLQE-------ERDAARAGQLSEHREL 348
             + + L  +L                A + +   L+E       E+ AA      + ++L
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851

Query: 349  ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408
            + +   +E+ER+  A+Q  +  E   A  ++ + QLE  +E+SQR              +
Sbjct: 1852 KEILLQVEDERKM-AEQYKEQAEKGNARVKQLKRQLEEAEEESQR--------------I 1896

Query: 409  QSEVRRLEGELDTARRERDALQLEMSLVQAR 439
             +  R+L+ ELD A    +A+  E++ ++++
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSK 1927



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%)

Query: 182  DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            + Q     LD E  ++ +  + I+ L+  + +LQ+ L    AA  K +     L + L  
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1148

Query: 242  VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
                    EA +TE+   L       EL R+K+++ VT L+++L E  E  + E +   +
Sbjct: 1149 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1197

Query: 302  QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
            +Q+  + +EE  + L               E+   A+A      + LE   A L  E + 
Sbjct: 1198 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1242

Query: 362  WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
              Q + +++   + L+    AQ++  + K     +A  E   ++  +Q+EV  + G L+ 
Sbjct: 1243 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298

Query: 422  ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
            A  +   L  +++ + ++ +  +  L+ E   +L   V+ +L Q +E             
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1344

Query: 482  RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
            R  LQD   +    +Q L   ++   +++++ +++ Q  A   E     ++    E+++ 
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404

Query: 539  NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585
             QQ EE+    + +E+ +  LQ   D+         QL+S             A     S
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464

Query: 586  SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637
            S    E ++ E         A++L   L+++ EA++EL     +L +   DL
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%)

Query: 190  LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
            L+ E  R +  +   + +  ++L+L++QL    AA +K      QL+K  A         
Sbjct: 931  LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 976

Query: 250  EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
            EA+    ++ L++E    +   +K  +    LE+ +S+    L  E+E A+   + +   
Sbjct: 977  EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
            E     L +RL+ E++    L++ +          H ++  L+A + E +   A++E   
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1089

Query: 370  KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429
                    EE QA L R  ++  ++  A      ++  ++  +  L+ +LD+ R  R+  
Sbjct: 1090 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1137

Query: 430  QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488
            + +   +    E+ + +LE  L     Q+      + + + L++A       H  Q+Q++
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197

Query: 489  SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528
              +H Q   EL  QL QFK   A  ++ +Q                 Q  ++ E +  + 
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257

Query: 529  QARVCELQSGNQQLEEQRVELVERLQAM 556
            +A+V ELQS     E  R EL +++  +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKL 1285



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%)

Query: 272  SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331
            ++Q+E +   E  L +  E   + +   +  +++   L EE+  L  +L+AE +     +
Sbjct: 848  TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907

Query: 332  EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391
            E R    A +      L  + A LEEE     Q + + K       + +Q  L+ E++  
Sbjct: 908  EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 960

Query: 392  QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449
            + EA A  + Q +    ++++++LE E+     + + L  E  L++ R       L  E 
Sbjct: 961  EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019

Query: 450  ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501
            E A  L +   +  +   E  +R          L +  RK   D S  H+Q  +L +Q+A
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079

Query: 502  QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544
            + K+++A++EE  Q      +  +A++          +  + +LQ       +   + E+
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139

Query: 545  QRVELVERLQAM 556
            Q+ +L E L+A+
Sbjct: 1140 QKRDLGEELEAL 1151



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%)

Query: 270  TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
            T+ K    VTR E+ +    + L + +E  +  + E + LE++   LT            
Sbjct: 839  TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 886

Query: 330  LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
              EE++      L E  + ET L A  EE R   A ++ +L+E    +  E +A+LE E+
Sbjct: 887  --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 935

Query: 389  EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448
            ++ Q       + Q +   +  ++  LE +L+     R  LQLE    +A+ +    +LE
Sbjct: 936  DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 984

Query: 449  SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
             E+ V  +Q        +L + + S L    +  E   K L  L  +H+    S +++ +
Sbjct: 985  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1040

Query: 505  VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
            V + ++EE+ +Q  E  + +L  + +    ++ +LQ+   +L+ Q  +  E LQA L   
Sbjct: 1041 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 561  WDEANQ 566
             DE  Q
Sbjct: 1100 DDEIAQ 1105



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 105/483 (21%), Positives = 201/483 (41%), Gaps = 75/483 (15%)

Query: 36   SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92
            S  YA  R   +AEA  +    L       E L+   +EL R+   L   +E  +  KD 
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1522

Query: 93   -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
              K++ E+E  +  L+T ++  +              E  +E     D+   L       
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1565

Query: 152  DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211
                  + QAL+  F R             D Q  RD  + E  +R+  +R +   +T +
Sbjct: 1566 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1605

Query: 212  LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266
             + ++Q A+A AA +K +  ++ L+      ++G  R EA +        ++  Q E + 
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1663

Query: 267  AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
            A  +R +   T    E+        L + QE     +R R+  + E++ L   L +    
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 327  CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377
               LQ+E  R  AR  QL E  E     +E +   + +  Q   Q  ++L       Q  
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 378  EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432
            E ++ QLER+ ++ +    E + A +++ +  +A +++++ +LE +++   RE+ A    
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 433  MSLVQARYESQRIQLESE--LAVQLEQ----------RVTERLAQAQESSLRQAASLREH 480
            +     + +   +Q+E E  +A Q ++          ++  +L +A+E S R  A+ R+ 
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903

Query: 481  HRK 483
             R+
Sbjct: 1904 QRE 1906



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%)

Query: 255  EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304
            E ++  ++E Q  +  + K +  +  LEQ  S+  E  N  QE  + +            
Sbjct: 852  EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911

Query: 305  ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354
                +++ LEE    +  RLE E+ R   LQ ER       L    +LE   AA      
Sbjct: 912  RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971

Query: 355  -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400
                       LE+E      Q ++L +  + L+E   +    L  E+EK++   +   +
Sbjct: 972  EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1029

Query: 401  TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
             +H+  + + EVR     +   EL+  +R+ +    +     A  ++Q  +L+ +LA + 
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 456  EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500
            E+      R+ + +AQ + ++L++   L  H     +DL  +          +++L  +L
Sbjct: 1090 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148

Query: 501  AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560
               K E+   E+     A   ELR  REQ    E+    + L+E+      ++Q M Q H
Sbjct: 1149 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 561  WDEANQL 567
                 +L
Sbjct: 1202 AQAVEEL 1208



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%)

Query: 344  EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403
            +  E++     L++ ++   + E++LKE      E+  +QL  EK   Q + QA  E   
Sbjct: 850  QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 901

Query: 404  QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463
                + +E   +   L   ++E + +  EM       E +  QL++E     +Q +    
Sbjct: 902  ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 464  AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509
               +E + RQ   L     E   K+L+D             + ++ L  +++     +AE
Sbjct: 958  QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017

Query: 510  REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
             EE          + + +  + E+RL +E+    EL+   ++LE    +  E++ A LQA
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1076

Query: 560  HWDEANQLLS 569
               E    L+
Sbjct: 1077 QIAELKMQLA 1086


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 93/404 (23%), Positives = 184/404 (45%), Gaps = 38/404 (9%)

Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
           RDAL  E  R        + L+ +  ELQ++L +A +   +    +++L + L R     
Sbjct: 168 RDALSLELYRNTITN---EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLL 224

Query: 247 NRHEAERTEVLRGLQEEH-QAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRE 305
            + +    +     QEE  +  E    KQ+E + R E+ L E  E   REQE  +++++E
Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE-QEGKMREQEE-KMRRQE 282

Query: 306 RETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQ- 364
           +   E+E++      E  +Q+    QEE+   +  ++ E  E        E+E + W Q 
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE-----KMREQEEKMWRQE 337

Query: 365 -----QEHQLKEHYQALQEESQAQLE-----REKEKSQREAQAAWETQHQL---ALVQSE 411
                QE Q++E  Q ++++ +   E     REKE+  RE +  WE + ++     ++  
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397

Query: 412 VRRLEGELDTARRERDALQL--EMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQES 469
            +++  E +T R + + +Q   E    Q   E Q+ +L  +     EQ   E++ + +E 
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ---EKMQEQEEK 454

Query: 470 SLRQAASLREHHRKQLQDLSGQHQQELASQLAQF---KVEMAEREER---QQQVAEDYEL 523
              Q   +R+      Q+     Q+++  Q  Q    + +M ++E++   Q++   + + 
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514

Query: 524 RLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567
           RL  ++ R+ E +   QQ E+ R E  ++ Q   +  WD+  ++
Sbjct: 515 RLREKEERMREQKKMWQQEEKMREE--KKTQEQEKKTWDQEEKM 556



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 77/406 (18%), Positives = 182/406 (44%), Gaps = 45/406 (11%)

Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADR---KKDTMIEQLDKTLARV 242
           +R+  +    + K      + L+ +  EL++Q  +    ++   +++ M EQ +K   + 
Sbjct: 271 MREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQE 330

Query: 243 VEGWNRHEA--ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNRE---QE 297
            + W + E   E+ + +R  +++ +  E    +Q E +   E+ + E  +   +E   QE
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390

Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALE 356
             R+++RE++  EEE        + ++Q   + ++E    +  +L E +E L       E
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 450

Query: 357 EERQTWAQQE----------HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLA 406
           +E + W Q+E           + K   Q    E + Q+  ++EK + + Q  W+ + ++ 
Sbjct: 451 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM- 509

Query: 407 LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQA 466
                      E D   RE++         + R + +  Q E ++  + + +  E+    
Sbjct: 510 ----------WEQDERLREKEE--------RMREQKKMWQQEEKMREEKKTQEQEKKTWD 551

Query: 467 QESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER---QQQVAEDYEL 523
           QE  +R+   +RE  +K  ++     +QE   ++ + + +M E+EE+   Q++  ++ E 
Sbjct: 552 QEEKMREEERMREREKKMREEEEMMREQE--EKMQEQEEKMREQEEKMWEQEEKMQEQEE 609

Query: 524 RLAREQARVCELQSGN--QQLEEQRVELVERLQAMLQAHWDEANQL 567
           ++  ++ ++ E +  +  Q+ EE   E  E++Q   +  W++  ++
Sbjct: 610 KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM 655



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 65/386 (16%), Positives = 170/386 (44%), Gaps = 30/386 (7%)

Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEA-ERTEVLRG 259
           E  +   + ++ E +Q++        ++D  + + ++ +    + W + E  +  E +R 
Sbjct: 337 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRE 396

Query: 260 LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLR 319
            +++ +  E T  +Q+E + + E+++ E  E   +E +  RL +++ +  E+E+      
Sbjct: 397 REKKMREEEETMREQEEKMQKQEENMWEQEE---KEWQQQRLPEQKEKLWEQEKMQ---- 449

Query: 320 LEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379
              EQ+     QEE+   +     + +++       E+E Q W +QE ++++  Q + ++
Sbjct: 450 ---EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW-EQEEKMRDQEQKMWDQ 505

Query: 380 SQAQLE-----REKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMS 434
            +   E     REKE+  RE +  W+ + ++   +    + +   D   + R+  ++   
Sbjct: 506 EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565

Query: 435 LVQARYESQRIQLESELAVQLEQRVTE---RLAQAQESSLRQAASLREHHRKQLQDLSGQ 491
             + R E + ++ + E   + E+++ E   ++ + +E    Q   + E   K  +     
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625

Query: 492 HQQELASQLAQFKVEMAERE----------ERQQQVAEDYELRLAREQARVCELQSGNQQ 541
             QE    + + + +M E+E            Q++   + E ++  ++ ++ E +   Q 
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685

Query: 542 LEEQRVELVERLQAMLQAHWDEANQL 567
            EE+  E  E+++   +  W +  ++
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKM 711



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 68/311 (21%), Positives = 135/311 (43%), Gaps = 46/311 (14%)

Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA--ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQS 284
           ++D M EQ +K   +  + W++ E   E+ E LR  ++E +  E  +  QQE   R E+ 
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR--EKEERMREQKKMWQQEEKMREEKK 541

Query: 285 LSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSE 344
             E  +    ++E  R ++R RE  ++ R+   +  E E++    +QE+ +  R      
Sbjct: 542 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK----MQEQEEKMR------ 591

Query: 345 HRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQ 404
               E      E+E +   Q+E   ++  +  ++E       E++K Q + +  WE + +
Sbjct: 592 ----EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE-------EEDKMQEQEEMMWEQEEK 640

Query: 405 LALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLA 464
           +   Q +  ++  + +  R + + ++ +   +Q + E  R Q              E   
Sbjct: 641 M---QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ--------------EEKM 683

Query: 465 QAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQF-KVEMAEREERQQQVAEDYEL 523
           Q QE  +R+     E  R Q + + GQ ++    +   + + EM E+EER +   E  + 
Sbjct: 684 QGQEEKMREQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740

Query: 524 RLAREQARVCE 534
           RL   + R  E
Sbjct: 741 RLPEHEERCSE 751



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 67/393 (17%), Positives = 179/393 (45%), Gaps = 26/393 (6%)

Query: 188 DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARV-VEGW 246
           + L  +  + +  E+ ++  + R+ E  ++L       R+++ M EQ +K      +   
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397

Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306
            +   E  E +R  +E+ Q  E    +Q+E   + +Q L E  E L  +++     Q + 
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKLWEQEK----MQEQE 452

Query: 307 ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHREL--ETLRAALEEERQTWAQ 364
           E + E+ + +  + E   Q   + ++E+   +  Q+ E  E   +  +   ++E + W Q
Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512

Query: 365 QEHQLKEHYQALQEES----QAQLEREKEKSQREAQAAWETQHQLA---LVQSEVRRLEG 417
            E +L+E  + ++E+     Q +  RE++K+Q + +  W+ + ++     ++   +++  
Sbjct: 513 DE-RLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 571

Query: 418 ELDTARRERDALQLEMSLVQARYES-----QRIQLESELAVQLEQRVTERLAQAQESSLR 472
           E +  R + + +Q +   ++ + E      +++Q + E   + E+++ E   Q +E  ++
Sbjct: 572 EEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE---QEEEDKMQ 628

Query: 473 QAASLREHHRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQA 530
           +   +     +++Q+   +   Q+E   +  +   E  E+ + Q++   + E ++  ++ 
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE 688

Query: 531 RVCELQSGNQQLEEQRVELVERLQAMLQAHWDE 563
           ++ E +   +  EE+     E++    +  W +
Sbjct: 689 KMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 721



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 84/398 (21%), Positives = 170/398 (42%), Gaps = 44/398 (11%)

Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRK-KDTMIEQLDKTLARVVEG 245
           ++AL  E   + H  R +   +T   EL+  L  +  A RK +D  + +      R+   
Sbjct: 80  QEALRREIEAQDHTIRILTCQKT---ELETALYYSQDAARKFEDGNLGESKDLAGRLHHS 136

Query: 246 WNRHEAERTEVLRGLQEEHQAA-----ELTRSKQQETVTRLEQSLS-EAMEALNRE-QES 298
           W+    E    L  +   H+ A     ELT+ +   ++     +++ E ++  N E QE 
Sbjct: 137 WH-FAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEK 195

Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358
            RL + E+  ++   + L  +LE  + +  + Q + +  +     +  EL      + ++
Sbjct: 196 LRLAESEKSEIQLNVKELKRKLE--RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 253

Query: 359 RQTWAQQEHQLKEHYQALQEES-----QAQLEREKEKSQREAQAAWETQHQL-----ALV 408
            +   +QE +L+E    ++E+      Q +  RE+EK  RE +     Q +L      + 
Sbjct: 254 EEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQ 313

Query: 409 QSEVRRLEGELDTARRERDALQLEMSL----VQARYESQRIQLESELAVQLEQRVTERLA 464
           + E +  E E     +E    + E  L     Q R + Q+++ + E   + ++R+ E+  
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE 373

Query: 465 Q--------AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQ 516
           +         QE  +++   +RE  +K  ++     +QE   Q  +  +   E +E QQQ
Sbjct: 374 RMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433

Query: 517 VAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
                  RL  ++ ++ E Q   Q+ EE+  E  E+++
Sbjct: 434 -------RLPEQKEKLWE-QEKMQEQEEKIWEQEEKIR 463


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 112/553 (20%), Positives = 241/553 (43%), Gaps = 51/553 (9%)

Query: 32  SEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKD 91
           +E+   LY S    +Q E  AR  +     S  H+    FA EL ++LS    +   KK 
Sbjct: 140 TELQMALYYSQHAVKQLEGEARDLI-----SRLHDSWK-FAGELEQALSAVATQ---KKK 190

Query: 92  GSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
             ++I E+   R  L   L+  R+T   + L       + +    +S+ +   LN + L+
Sbjct: 191 ADRYIEELTKERDALS--LELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 248

Query: 152 D-------LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRK-HCERH 203
                   L P    QA  +   +             +   L + L+ +   +    E  
Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308

Query: 204 IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEG-WNRHEAERT--EVLRGL 260
           IQ  + ++ E ++++       R+++  I + ++ + R  E  W + E  R   E++   
Sbjct: 309 IQEWEEKIQEQEEKI-------REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 361

Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320
           +E+ +  E    +++E +  LE+ + E  +   REQE  R Q+ E+   +E+RQ    ++
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKI--REQEEKR-QEEEKIREQEKRQEQEAKM 418

Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRELETL--RAALEEERQTWAQQEHQLKEHYQALQE 378
             ++++   ++E+ +  R  +    R+ E +  +  + EE +   Q+E   +E     QE
Sbjct: 419 WRQEEK---IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 475

Query: 379 ESQAQLER--EKEKSQREAQAAWETQHQLALVQSEVRRLEGEL-----------DTARRE 425
           E   Q E+  E+EK +++ +  W  + ++   + ++R  E ++           +  R +
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ 535

Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK-Q 484
            + ++ +  ++Q + E    Q E     +  +R  E++ + +E    Q   +RE   K  
Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW 595

Query: 485 LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
            Q+   + Q+E+  +  +   E  E+   Q++  ++ E ++ R++ ++ E +   +Q EE
Sbjct: 596 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 655

Query: 545 QRVELVERLQAML 557
           +  E  E L+A +
Sbjct: 656 KMQEHQEHLEAAI 668



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 75/405 (18%), Positives = 179/405 (44%), Gaps = 31/405 (7%)

Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV-- 243
           L++ L    + +   + +++ L+ R LE  + L        + D + ++L    A++   
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELK-RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284

Query: 244 ----EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQE-- 297
               E WNR   ++ E +   +E+ Q  E    +Q+E +   E+ + E  E + R++E  
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344

Query: 298 -SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE 356
                + R +E +  E++    RLE       ++ E+ +  R  +   H E E +R   E
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEE------MMWEKEEKIRELEEKMH-EQEKIREQEE 397

Query: 357 EERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQ---HQLALVQSEVR 413
           + ++    +E + ++  +A     + ++  ++EK + + +  W  +   H+   ++ E +
Sbjct: 398 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 457

Query: 414 RLEGELDTARRERDALQLEMSLVQAR-YESQRIQLESELAVQLEQRV----------TER 462
           R E E    + E+   Q E+   + + +E ++I+ + E   + E+++           E+
Sbjct: 458 RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEK 517

Query: 463 LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522
           + + +E    Q   +RE   K  +      +QE      + K++  E+  RQ++   + E
Sbjct: 518 MWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577

Query: 523 LRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567
            ++  ++ ++ E +    + EE+  E  E +Q   +  W++  ++
Sbjct: 578 EKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 96/398 (24%), Positives = 176/398 (44%), Gaps = 45/398 (11%)

Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR---GLQEEHQAAEL 269
           ELQ+ L+      +K D  IE+L K    +     R+     E+ +    LQE+   AE 
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239

Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
            +S+ Q  V  L++ L  A   L + Q +   ++  R+  E   Q   +R + E+     
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM---W 296

Query: 330 LQEERDAARAGQLSEHRE-LETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
            QEER   + G++ E  E +      L E+ +   +QE +L+E  +  ++E Q Q + EK
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356

Query: 389 ------------EKSQREAQAAWETQHQLALVQSEVRRLE---GELDTARRERDALQLEM 433
                       EK  R+ +  WE + Q+   + ++R  E    E D   RE++    E 
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416

Query: 434 SLVQARYESQRIQ----------LESELAVQLEQRVTER--LAQAQESSLRQAASLREHH 481
             +  + E  R +           + E  +Q E+R+ ER    + +E ++R+     E  
Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ---EEKM 473

Query: 482 RKQLQDLSGQHQQELASQ-LAQFKVEMAEREERQQQVAEDYE----LRLARE---QARVC 533
           +KQ +++  Q ++E   Q L + K ++ E+E+ Q+Q  + +E    +R   E   Q +  
Sbjct: 474 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533

Query: 534 ELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTT 571
             Q   ++ E+Q  E  E+++   Q  WD+  ++   T
Sbjct: 534 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 77/422 (18%), Positives = 192/422 (45%), Gaps = 28/422 (6%)

Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260
           E  +   + ++ E +Q++        ++D  + + ++ +    + W + E  R E     
Sbjct: 375 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434

Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320
           QE+    +  + +++E +   E+ + E  E + REQE    +Q E    +EE++    RL
Sbjct: 435 QEKKTRDQEEKMQEEERIREREKKMREEEETM-REQEEKMQKQEENMWEQEEKEWQQQRL 493

Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALEEERQTWAQ-----QEHQLKEHYQ 374
             ++++  + ++E+   +  ++ E  E +        +E++ W Q     QE Q+ E  +
Sbjct: 494 PEQKEK--LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551

Query: 375 ALQEESQA---QLEREKEKSQREAQAAWETQHQL---ALVQSEVRRLEGELDTARRERDA 428
            ++++ Q    Q ER ++K+Q + +  W+ + ++     ++   +++  E +  R + + 
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611

Query: 429 LQLEMSLVQARYE-----SQRIQLESELAVQLEQRVTERLAQ--AQESSLRQAASLREHH 481
           +Q +   +Q + E      +++Q + E   + E+++ E+  +   Q+    Q   L EH 
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671

Query: 482 RKQLQDLSGQHQQELASQLAQFKVEMAEREER---QQQVAEDYELRLAREQARVCELQSG 538
           + Q Q+   Q Q+E   +  + + +  E+E++   Q+++ E+  +R   ++ R  E +  
Sbjct: 672 KMQEQE-KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR--EEEEM 728

Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERR 598
            ++ EE+  E  E++Q   +  W++  ++             P         E  +E+ +
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788

Query: 599 VW 600
           +W
Sbjct: 789 IW 790



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 72/345 (20%), Positives = 147/345 (42%), Gaps = 18/345 (5%)

Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA----ERTEVLRGLQEEHQAAELTRSKQQETVTRLE 282
           ++D M EQ +K   +  + W++ E      + +  +   +E +  E  R +++E   R E
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601

Query: 283 QSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEE------RDA 336
           + +    E   +EQE    +Q E+   +EE+         EQ+     QEE      R  
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661

Query: 337 ARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLE-----REKEKS 391
            +  +L EH +++      E+E + W Q++ + K   Q  +   Q ++      RE+EK 
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721

Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
            RE +     Q +    Q E  + + E    + E+   Q E    Q R   Q+ +L    
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781

Query: 452 AVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVE--MAE 509
            +Q ++++ E+  + ++   +      E  R Q + + GQ ++    +   +  E  M  
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQ-EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG 840

Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
           +EE+     E  E ++  ++ ++ E +   +  EE+  E  E+++
Sbjct: 841 QEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 51/203 (25%), Positives = 86/203 (42%), Gaps = 35/203 (17%)

Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEM-------------------SLVQA 438
           A E Q  L+ V +  ++ +  ++   +ERDAL LE+                    L  A
Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA 237

Query: 439 RYESQRIQLESELAVQLEQRVTERLAQAQESSL-----RQAASLREHHRKQLQDLSGQHQ 493
             E   IQL  +   +  +R    L Q Q ++L     RQ   LRE  +K  +      +
Sbjct: 238 ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297

Query: 494 QELASQLAQFKVEMAEREE---RQQQVAEDYELRL------AREQARVCELQSGNQQLEE 544
           QE   +L + + +M E+EE   RQ++   + E  L       REQ  + E +   Q+ EE
Sbjct: 298 QE--ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355

Query: 545 QRVELVERLQAMLQAHWDEANQL 567
           +  E  E+++   +  W +  +L
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERL 378



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 29/159 (18%), Positives = 73/159 (45%), Gaps = 7/159 (4%)

Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA------ERTEVLRGLQEEHQAAELTRSKQQETVTR 280
           +++ M EQ +K   +  E W + E       +  E  R  +++ +  E  + ++QE +  
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791

Query: 281 LEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAG 340
            E+ + +  E +  ++E  R Q+ +    EE+      ++  ++++    QEE+   +  
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG-QEEKMWGQEE 850

Query: 341 QLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379
           ++ E  + +  +   +EE+    +++ + +E     QEE
Sbjct: 851 KMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 90/449 (20%), Positives = 198/449 (44%), Gaps = 51/449 (11%)

Query: 148 RPLQDLSPSSSAQALEELFPRYTSLRPGPPL-----NPPDFQGLRDALDSEHTRRKHCER 202
           +PL  L P +     EE          G P+     +    + L+  +  +    K C+ 
Sbjct: 246 KPLPQLEPQAEVFTKEE-----NPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE 300

Query: 203 HIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQE 262
            IQS + +   L  +          K+ + EQLD+ L  + +  + H AE+T+++  L++
Sbjct: 301 TIQSHKEQCTLLTSE----------KEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350

Query: 263 EHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER-------ETLEEERQA 315
                E     +   +   ++ + E +E   +E+E A+L+ R +       E  E++ ++
Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEM--KEEEIAQLRSRIKQMTTQGEELREQKEKS 408

Query: 316 LTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEH--- 372
                E  ++     Q+  +A R  +     +++T+    EEER +  Q+  ++K+    
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468

Query: 373 ------------YQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420
                        Q L E+  A+ E+E  K  +  +  ++ Q ++AL +S+   L+   +
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528

Query: 421 TARRER---DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
             ++E    + L+L+   +    E++   L+ E A     R+ E L  + E SL++  + 
Sbjct: 529 KEQQESLALEELELQKKAILTESENKLRDLQQE-AETYRTRILE-LESSLEKSLQENKNQ 586

Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQS 537
            +     L+    +H +E+   + + K E+ E  + QQ      +L++ ++Q +  E++ 
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTEL-ESLKHQQDALWTEKLQVLKQQYQT-EMEK 644

Query: 538 GNQQLEEQRVELVERLQAMLQAHWDEANQ 566
             ++ E+++  L++  + + QAH +E N+
Sbjct: 645 LREKCEQEKETLLKDKEIIFQAHIEEMNE 673



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 94/408 (23%), Positives = 194/408 (47%), Gaps = 79/408 (19%)

Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQ--------------QQLAVAVAADRKKD----TM 231
           L     + +  ++  ++ +TR+LEL+              + LAV + A++ K     T+
Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607

Query: 232 IEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAA-ELTRSK---QQETVTRLEQSLSE 287
           + +  KT    ++  ++ +A  TE L+ L++++Q   E  R K   ++ET+ + ++ + +
Sbjct: 608 MVEKHKTELESLK--HQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665

Query: 288 A-MEALNREQ-ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEH 345
           A +E +N +  E   ++Q E E+L  E   +       ++   VL+++ D  +       
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK------- 718

Query: 346 RELETLRAALEEERQTWAQQ-EHQLKEHYQALQEESQA------QLE---REKEKSQREA 395
              + L A ++E++    QQ +  +KEH  ++Q   +A      QLE   +E++K  +E 
Sbjct: 719 ---QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775

Query: 396 QAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQAR---YESQRIQLESELA 452
           QA  E       ++++++R EGEL  A  + D  Q   S    +   YE Q  QL+ +L 
Sbjct: 776 QAHVEN------LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829

Query: 453 VQLEQRV--TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAER 510
               +R+  T+++A+  E+  +   +  + H+ Q+QDL           + Q + + +E 
Sbjct: 830 DLETERILLTKQVAEV-EAQKKDVCTELDAHKIQVQDL-----------MQQLEKQNSEM 877

Query: 511 EERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQ 558
           E++ + + + YE +L          + GN++ E+ +  LVE+   +LQ
Sbjct: 878 EQKVKSLTQVYESKL----------EDGNKEQEQTKQILVEKENMILQ 915



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 83/399 (20%), Positives = 180/399 (45%), Gaps = 50/399 (12%)

Query: 191  DSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHE 250
            + E T   H E   Q  Q R+++L+     A A   +  +MI  L + L    + ++   
Sbjct: 1758 EKEETVSSHFEMRCQ-YQERLIKLEH----AEAKQHEDQSMIGHLQEELEEKNKKYSLIV 1812

Query: 251  AERTEVLRG---------LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
            A+  E   G         L+      + T  +++ T   LEQ + E    L R++E  R+
Sbjct: 1813 AQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRV 1872

Query: 302  QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQL----------SEHRELETL 351
            +  E  +  E+ QAL  +++   +   +L+E  +      L          ++H +LE  
Sbjct: 1873 EMEELTSKYEKLQALQ-QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931

Query: 352  RAALEEERQTWAQQEHQLKEHYQALQEESQAQLE-REKEKSQREAQAAWETQHQLALV-Q 409
             A  E E+Q   ++  +L++  + L++E Q +LE  +KE  Q   +   + Q  L L   
Sbjct: 1932 LAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN 1991

Query: 410  SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLE-QRVTERLAQAQE 468
            S +++L  E +T   +++  +LEM++ +   ++Q ++ E   + Q E  ++ +++A+  +
Sbjct: 1992 STLKQLMREFNTQLAQKEQ-ELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050

Query: 469  SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAE--------- 519
               R A        K+ +++    ++E+ +++   + ++ E +++ QQ  E         
Sbjct: 2051 DLKRTA--------KRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDN 2102

Query: 520  ----DYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
                + + +LA++   + + +   Q+  EQ   L +RL+
Sbjct: 2103 VTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 120/592 (20%), Positives = 241/592 (40%), Gaps = 63/592 (10%)

Query: 3   TSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTS 62
           T  ++P S    E ++ D +    L  +   V  Q     R     ++       L S  
Sbjct: 259 TKEENPESD--GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK 316

Query: 63  PP-HEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDP 121
               E LD   QEL +       K+L   + +K I ++   +  ++ + Q          
Sbjct: 317 EALQEQLDERLQELEKI------KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETK 370

Query: 122 LIPGAGSERREEDSFDSDSTATLLNTR--PLQDLSPSSSAQALEELFPRYTSLRPGPPLN 179
                  E +EE+     S    + T+   L++    S   A EEL    ++ +      
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430

Query: 180 PPDFQGLRDALDSE-HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKT 238
               + L+  +D +  T  K  E    SLQ  +  ++Q++      D  K +  EQ+ K 
Sbjct: 431 ----RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV-----DVMKKSSEEQIAKL 481

Query: 239 LARVVEGWNRHEAERTEVLRGLQEEHQ-----AAELTRSKQQETVTRLEQSLSEAMEALN 293
                +   R E E T+ L+  + E Q     A E ++S+  +     EQ  S A+E L 
Sbjct: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELE 541

Query: 294 REQESARLQQRERETLEEERQALTLR---LEAEQQRCCVLQEERDAARAGQLSEHRELET 350
             Q+ A L + E +  + +++A T R   LE E      LQE ++ ++   L+ H E E 
Sbjct: 542 L-QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK--DLAVHLEAEK 598

Query: 351 -----------------LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQR 393
                            L +   ++   W ++   LK+ YQ   E+ + + E+EKE   +
Sbjct: 599 NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658

Query: 394 EAQAAWE---------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQR 444
           + +  ++         T  +L + Q+E+  L  EL    + R  L+ E+S+++ + +  +
Sbjct: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718

Query: 445 IQLESELAVQL--EQRVTERLAQAQESSLRQAASLREHHRKQLQDL---SGQHQQELASQ 499
            +LE+++  Q    Q+  + + +  E S+++     +    QL+ L     +H +E  + 
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778

Query: 500 LAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVE 551
           +   + ++   E   QQ +   ++  + + A   + ++  +QL + + +L++
Sbjct: 779 VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 115/524 (21%), Positives = 218/524 (41%), Gaps = 73/524 (13%)

Query: 73   QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERRE 132
            Q+L     +G EK+ + K+  + I  +E+    ++  L+T                +++E
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET----------------KKKE 1607

Query: 133  EDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDS 192
             +  +    +     + L+D   S SA  L EL       +    +     Q L    + 
Sbjct: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAEL-----KRKAEQKIAAIKKQLLSQMEEK 1662

Query: 193  EHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE 252
            E   +K  E H+  L T++ E ++++ +    + K  ++     +TL  +V    ++ A 
Sbjct: 1663 EEQYKKGTESHLSELNTKLQEREREVHI---LEEKLKSVESSQSETL--IVPRSAKNVAA 1717

Query: 253  RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR---EQESARLQQRERETL 309
             TE     QEE  +    +   +E ++ L+++L+E  + L R   E+E       E    
Sbjct: 1718 YTE-----QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772

Query: 310  EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAAL---EEERQTWAQQE 366
             +ER       EA+Q          D +  G L E  E +  + +L   +   +   +  
Sbjct: 1773 YQERLIKLEHAEAKQ--------HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNN 1824

Query: 367  HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426
             Q K++ + + ++ Q  L+ EKE + +  +   +      + Q EV R+E E  T++ E+
Sbjct: 1825 IQAKQNLENVFDDVQKTLQ-EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEK 1883

Query: 427  -DAL-QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHR-- 482
              AL Q++          +  + +S+  +   + ++   AQ  +   + A + RE  +  
Sbjct: 1884 LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943

Query: 483  -------KQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELR-------LARE 528
                   K L+ L  +HQQEL     ++     EREE+ +Q  ED EL+       L RE
Sbjct: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYD---QEREEKIKQEQEDLELKHNSTLKQLMRE 2000

Query: 529  QARVCELQSGNQQLEEQRVELVERLQ----AMLQAHWDEANQLL 568
                 +L    Q+LE    E + + Q     +L++H +E NQLL
Sbjct: 2001 FN--TQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL 2042



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 74/376 (19%), Positives = 174/376 (46%), Gaps = 41/376 (10%)

Query: 195  TRRKHCERHIQSLQTRVL-------ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247
            +R  HC+     ++  +L       EL+ QL        +++T+     +   ++ E  N
Sbjct: 1248 SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT---EEQNTLNISFQQATHQLEEKEN 1304

Query: 248  RHEAERTEV------LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
            + ++ + ++         LQ+E    +   S+++  +T+L++ LSE + A+   +E  + 
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364

Query: 302  QQRERETLEEERQALTLRLE------AEQQRCCVLQEERDAARAGQLSEHRELETLRAAL 355
            ++ E  +L ++   L ++L+       ++     L+++ D  +   L + ++L      L
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424

Query: 356  EEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE-VRR 414
             +E+ +  +Q       +   ++++Q++   + + + +E Q   E + + A  + E +  
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRF-TQHQNTVKELQIQLELKSKEAYEKDEQINL 1483

Query: 415  LEGELDTARRERDALQLEMSLVQARYESQRIQLESEL------AVQLEQRVTERLAQAQE 468
            L+ ELD   +  D L+ EM   +++ E +   LE+EL       ++LE  +T++  + + 
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIE- 1542

Query: 469  SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528
                   SL E  +   Q    +H +EL  +L  F+ E+ E ++ + + AE+  L L  +
Sbjct: 1543 -------SLNEVLKNYNQQKDIEH-KELVQKLQHFQ-ELGEEKDNRVKEAEEKILTLENQ 1593

Query: 529  -QARVCELQSGNQQLE 543
              +   EL++  ++LE
Sbjct: 1594 VYSMKAELETKKKELE 1609



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 64/313 (20%), Positives = 151/313 (48%), Gaps = 32/313 (10%)

Query: 211  VLELQQQLAVAV-AADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAEL 269
            +L+  Q L+  V    ++K + +EQ+D    +  E   + ++  T+    ++E     EL
Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLEL 1469

Query: 270  TRSKQQETVTRLEQS--LSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRC 327
               K +E   + EQ   L E ++  N+  +  + +  + ++  E++++  L  E + Q  
Sbjct: 1470 ---KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES-NLETELKSQTA 1525

Query: 328  CVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLERE 387
             +++ E    +     +  E+E+L   L+   Q   Q++ + KE  Q LQ   +  L  E
Sbjct: 1526 RIMELEDHITQ-----KTIEIESLNEVLKNYNQ---QKDIEHKELVQKLQHFQE--LGEE 1575

Query: 388  KEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL 447
            K+   +EA+       ++  ++++V  ++ EL+T ++E + + L +   +   ++   +L
Sbjct: 1576 KDNRVKEAE------EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL 1629

Query: 448  ESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507
            ESE A         +LA+ +  + ++ A++++    Q+++   Q+++   S L++   ++
Sbjct: 1630 ESESAA--------KLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681

Query: 508  AEREERQQQVAED 520
             ER ER+  + E+
Sbjct: 1682 QER-EREVHILEE 1693



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 79/405 (19%), Positives = 174/405 (42%), Gaps = 62/405 (15%)

Query: 182  DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
            + + L   L      R   E  +  L+ +  +++Q+L   +  D +K+   +Q+D  +  
Sbjct: 685  ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKM--DEQKNHHQQQVDSIIKE 742

Query: 242  VVEGWNRHEAERTEVLRGLQ----------EEHQAAELTRSKQQETVTRLEQSLSEAMEA 291
                  R E    + +  L+          +EHQA        +  + R E  L +A   
Sbjct: 743  HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHV---ENLEADIKRSEGELQQASAK 799

Query: 292  LN---------------REQESARLQQRERETLEEERQALT---LRLEAEQQRCCVLQEE 333
            L+                E++ A+LQQ+  + LE ER  LT     +EA+++  C    E
Sbjct: 800  LDVFQSYQSATHEQTKAYEEQLAQLQQKLLD-LETERILLTKQVAEVEAQKKDVCT---E 855

Query: 334  RDAARAGQLSEHRELETLRAALEEERQTWAQ-QEHQLKEHYQALQEESQAQLEREKEKSQ 392
             DA +       ++LE   + +E++ ++  Q  E +L++  +  ++  Q  +E+E    Q
Sbjct: 856  LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915

Query: 393  REAQAAWETQ---HQLALVQSEVRRLEGELDT----ARRERDALQLEMSLVQARYESQRI 445
                   E +    +L+  +  +  L  E +T      ++ + ++ +   +Q   + + +
Sbjct: 916  MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975

Query: 446  QLESELAVQLEQRVTE-------------RLAQAQESSLRQAAS-LREHHRKQLQDLSGQ 491
              E++L  +LE    E              +AQA  + +  A S L  + ++Q++ L+  
Sbjct: 976  DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035

Query: 492  HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQ 536
            H++EL   ++ ++ ++ ++ E  Q++   +E++L  ++  V EL+
Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEI---HEIQLQEKEQEVAELK 1077



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 68/350 (19%), Positives = 149/350 (42%), Gaps = 22/350 (6%)

Query: 227  KKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS 286
            +K+ MI Q+ +   + +E   +  + + + +  L EE++     + K+ E V +  + + 
Sbjct: 908  EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967

Query: 287  EAMEALNREQESARLQQRERETLE---EERQALTLRLEAEQQRCCVLQEERDAARAGQLS 343
            E ++    +QE+   ++ E   LE   +E+Q     LE  Q     + +        Q  
Sbjct: 968  ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027

Query: 344  EHREL-ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQ 402
            +   L E  R  L +    W   E +L +  + LQE  + QL+   EK Q  A    E +
Sbjct: 1028 QIESLTEVHRRELNDVISIW---EKKLNQQAEELQEIHEIQLQ---EKEQEVA----ELK 1077

Query: 403  HQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTER 462
             ++ L   E   +  E+   + E       ++ +Q + + +   + S     L Q  T+ 
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS-----LAQDETKL 1132

Query: 463  LAQAQESSLRQAASLREHH--RKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520
             A  ++  +    SL+E+   ++QL +L     +E   ++++   ++   +E  Q +   
Sbjct: 1133 KAHLEKLEVDLNKSLKENTFLQEQLVELK-MLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191

Query: 521  YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLST 570
            +E      + +  E +  +++L  Q     ++ +A+L+A  +E   + S+
Sbjct: 1192 HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS 1241



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 93/470 (19%), Positives = 181/470 (38%), Gaps = 105/470 (22%)

Query: 198  KHCERHIQSL---QTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT 254
            K    H+ SL   +T++    ++L V +    K++T +++    L  + E   R  +E T
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175

Query: 255  EVLRGLQEEHQAAELTRSKQQETVT-------RLEQSLSEAMEALNREQESARLQQRERE 307
              L+   EE Q+ + +  K  +++        +L + L+  ++   ++ E A L+ +  E
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE-ALLEAKTNE 1234

Query: 308  TLE---EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT--- 361
             +     +  A+  R+   Q R   ++E    A   +     ELE     L EE+ T   
Sbjct: 1235 LINISSSKTNAILSRISHCQHRTTKVKE----ALLIKTCTVSELEAQLRQLTEEQNTLNI 1290

Query: 362  -WAQQEHQLKEHYQALQEESQ--AQLEREKEKSQREA----QAAWETQHQLALVQSEVRR 414
             + Q  HQL+E    ++        L  EKE  Q+E     QAA E +  +  ++ E+  
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350

Query: 415  LEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV------------QLEQRVTER 462
                +   + E    ++E+S +  +     +QL++ +++            Q ++   E 
Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410

Query: 463  LAQAQESSLRQAASLRE----------------HHRKQLQDLSGQHQ------------- 493
            L Q Q+ S +     +E                  +K+ Q    QHQ             
Sbjct: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK 1470

Query: 494  ---------------QELASQLAQF---KVEMAEREERQQQVAEDYELRLAREQARVCEL 535
                           +EL  Q  +F   K EM + + + ++   + E  L  + AR+ EL
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530

Query: 536  QSG------------------NQQLEEQRVELVERLQAMLQAHWDEANQL 567
            +                    NQQ + +  ELV++LQ   +   ++ N++
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 80/411 (19%), Positives = 167/411 (40%), Gaps = 74/411 (18%)

Query: 205 QSLQTRVLELQQQLAVAVAADR---------KKDTMIEQLDKTLARVVEGWNRHEAERTE 255
           Q +     +LQQ LA A A+           +  +  EQLD+       G  +  A++ +
Sbjct: 7   QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66

Query: 256 V----LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR-EQESARLQQRERETLE 310
           +    +  L        L RS  +E++ R     + + E+LNR + +S+         ++
Sbjct: 67  LRVPSVESLFRSPIKESLFRSSSKESLVR-----TSSRESLNRLDLDSSTASFDPPSDMD 121

Query: 311 EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLK 370
            E + L                      +  L++ + ++ LR  +E    ++  +  +L 
Sbjct: 122 SEAEDLV-------------------GNSDSLNKEQLIQRLRR-MERSLSSYRGKYSELV 161

Query: 371 EHYQALQEES---QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427
             YQ LQ E    Q  L + ++KS R      E + +L + Q   + L+ E D +  E+D
Sbjct: 162 TAYQMLQREKKKLQGILSQSQDKSLRRIA---ELREELQMDQQAKKHLQEEFDASLEEKD 218

Query: 428 ----ALQLEMSLVQARYESQRI---------QLESELAVQLEQR---------VTERLAQ 465
                LQ ++SL++ R  +  +         QLE +  V  ++          V +  + 
Sbjct: 219 QYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSV 278

Query: 466 AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
               +L+Q    +E+  K+ ++    H+++     ++ +    + +ER Q++ +  +L +
Sbjct: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM 338

Query: 526 AREQARVCELQSGN---QQLEEQR----VELVERLQAMLQAHWDEANQLLS 569
           A +   + +L+      +QLE+ +     E   ++   L+   +E  QL S
Sbjct: 339 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,686,158
Number of Sequences: 37866
Number of extensions: 2299642
Number of successful extensions: 37360
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 489
Number of HSP's successfully gapped in prelim test: 1671
Number of HSP's that attempted gapping in prelim test: 16875
Number of HSP's gapped (non-prelim): 10245
length of query: 925
length of database: 18,247,518
effective HSP length: 112
effective length of query: 813
effective length of database: 14,006,526
effective search space: 11387305638
effective search space used: 11387305638
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.