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Search of human proteins with 77812678
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|77812678 inorganic pyrophosphatase 2 isoform 2 precursor
[Homo sapiens]
(305 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|77812678 inorganic pyrophosphatase 2 isoform 2 precursor [Hom... 632 0.0
gi|29171702 inorganic pyrophosphatase 2 isoform 1 precursor [Hom... 617 e-177
gi|77812684 inorganic pyrophosphatase 2 isoform 5 precursor [Hom... 568 e-162
gi|77812680 inorganic pyrophosphatase 2 isoform 3 precursor [Hom... 330 1e-90
gi|11056044 pyrophosphatase 1 [Homo sapiens] 319 2e-87
gi|77812682 inorganic pyrophosphatase 2 isoform 4 precursor [Hom... 246 2e-65
gi|57165424 cullin 4A isoform 1 [Homo sapiens] 30 2.0
gi|11140811 cullin 4A isoform 2 [Homo sapiens] 30 2.0
gi|88501736 DnaJ (Hsp40) homolog, subfamily B, member 2 isoform ... 29 4.5
gi|27151736 DnaJ (Hsp40) homolog, subfamily B, member 2 isoform ... 29 4.5
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 28 7.7
>gi|77812678 inorganic pyrophosphatase 2 isoform 2 precursor [Homo
sapiens]
Length = 305
Score = 632 bits (1631), Expect = 0.0
Identities = 305/305 (100%), Positives = 305/305 (100%)
Query: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 60
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
Sbjct: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 60
Query: 61 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY 120
SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
Sbjct: 61 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY 120
Query: 121 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA 180
VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA
Sbjct: 121 VKDGKLRYVANIFPYKGYIWNYGTLPQILSCGEVIHVKILGILALIDEGETDWKLIAINA 180
Query: 181 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK 240
NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK
Sbjct: 181 NDPEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIK 240
Query: 241 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW 300
STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW
Sbjct: 241 STHQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVW 300
Query: 301 HFLGK 305
HFLGK
Sbjct: 301 HFLGK 305
>gi|29171702 inorganic pyrophosphatase 2 isoform 1 precursor [Homo
sapiens]
Length = 334
Score = 617 bits (1591), Expect = e-177
Identities = 305/334 (91%), Positives = 305/334 (91%), Gaps = 29/334 (8%)
Query: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 60
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
Sbjct: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 60
Query: 61 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY 120
SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
Sbjct: 61 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY 120
Query: 121 VKDGKLRYVANIFPYKGYIWNYGTLPQ-----------------------------ILSC 151
VKDGKLRYVANIFPYKGYIWNYGTLPQ ILSC
Sbjct: 121 VKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSC 180
Query: 152 GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL 211
GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL
Sbjct: 181 GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL 240
Query: 212 YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF 271
YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF
Sbjct: 241 YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF 300
Query: 272 RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 305
RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
Sbjct: 301 RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 334
>gi|77812684 inorganic pyrophosphatase 2 isoform 5 precursor [Homo
sapiens]
Length = 316
Score = 568 bits (1465), Expect = e-162
Identities = 287/334 (85%), Positives = 287/334 (85%), Gaps = 47/334 (14%)
Query: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 60
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
Sbjct: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 60
Query: 61 SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY 120
SPFHDIPLKVNSKEENGIPMKKARNDEYE IATKEPMNPIKQY
Sbjct: 61 SPFHDIPLKVNSKEENGIPMKKARNDEYE------------------IATKEPMNPIKQY 102
Query: 121 VKDGKLRYVANIFPYKGYIWNYGTLPQ-----------------------------ILSC 151
VKDGKLRYVANIFPYKGYIWNYGTLPQ ILSC
Sbjct: 103 VKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSC 162
Query: 152 GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL 211
GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL
Sbjct: 163 GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL 222
Query: 212 YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF 271
YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF
Sbjct: 223 YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF 282
Query: 272 RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 305
RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
Sbjct: 283 RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 316
>gi|77812680 inorganic pyrophosphatase 2 isoform 3 precursor [Homo
sapiens]
Length = 232
Score = 330 bits (846), Expect = 1e-90
Identities = 158/159 (99%), Positives = 159/159 (100%)
Query: 147 QILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATL 206
+ILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATL
Sbjct: 74 EILSCGEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATL 133
Query: 207 NWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQI 266
NWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQI
Sbjct: 134 NWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQI 193
Query: 267 SDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 305
SDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
Sbjct: 194 SDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 232
Score = 153 bits (387), Expect = 2e-37
Identities = 74/74 (100%), Positives = 74/74 (100%)
Query: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 60
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
Sbjct: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI 60
Query: 61 SPFHDIPLKVNSKE 74
SPFHDIPLKVNSKE
Sbjct: 61 SPFHDIPLKVNSKE 74
>gi|11056044 pyrophosphatase 1 [Homo sapiens]
Length = 289
Score = 319 bits (818), Expect = 2e-87
Identities = 153/283 (54%), Positives = 200/283 (70%), Gaps = 46/283 (16%)
Query: 32 MALYHTEERGQPCSQNYRLFFKNVTGHYISPFHDIPLKVNSKEENGIPMKKARNDEYENL 91
M+ + TEER P S YR+F KN G YISPFHDIP+ + +++
Sbjct: 1 MSGFSTEERAAPFSLEYRVFLKNEKGQYISPFHDIPIYAD-----------------KDV 43
Query: 92 FNMIVEIPRWTNAKMEIATKEPMNPIKQYVKDGKLRYVANIFPYKGYIWNYGTLPQ---- 147
F+M+VE+PRW+NAKMEIATK+P+NPIKQ VK GKLRYVAN+FPYKGYIWNYG +PQ
Sbjct: 44 FHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWED 103
Query: 148 -------------------------ILSCGEVIHVKILGILALIDEGETDWKLIAINAND 182
+ + GE+I VK+LGILA+IDEGETDWK+IAIN +D
Sbjct: 104 PGHNDKHTGCCGDNDPIDVCEIGSKVCARGEIIGVKVLGILAMIDEGETDWKVIAINVDD 163
Query: 183 PEASKFHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKST 242
P+A+ ++DI+DVK+ KPGYLEAT++WFR YKVPDGKPEN+FAFN EFK+K FA+++IKST
Sbjct: 164 PDAANYNDINDVKRLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFAIDIIKST 223
Query: 243 HQCWKALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESV 285
H WKAL+ KK NG I+C N +S+SPF+C + AR++V+++
Sbjct: 224 HDHWKALVTKKTNGKGISCMNTTLSESPFKCDPDAARAIVDAL 266
>gi|77812682 inorganic pyrophosphatase 2 isoform 4 precursor [Homo
sapiens]
Length = 168
Score = 246 bits (627), Expect = 2e-65
Identities = 116/118 (98%), Positives = 117/118 (99%)
Query: 188 FHDIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWK 247
F +IDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWK
Sbjct: 51 FFNIDDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWK 110
Query: 248 ALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 305
ALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
Sbjct: 111 ALLMKKCNGGAINCTNVQISDSPFRCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK 168
Score = 107 bits (267), Expect = 1e-23
Identities = 52/52 (100%), Positives = 52/52 (100%)
Query: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFF 52
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFF
Sbjct: 1 MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFF 52
>gi|57165424 cullin 4A isoform 1 [Homo sapiens]
Length = 759
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 9/73 (12%)
Query: 175 LIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFR------LYKVPDGKPE---NQFAF 225
L+ + N+ + F +I + L TL L K P GK ++F F
Sbjct: 597 LVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIF 656
Query: 226 NGEFKNKAFALEV 238
NGEFK+K F +++
Sbjct: 657 NGEFKHKLFRIKI 669
>gi|11140811 cullin 4A isoform 2 [Homo sapiens]
Length = 659
Score = 30.4 bits (67), Expect = 2.0
Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 9/73 (12%)
Query: 175 LIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFR------LYKVPDGKPE---NQFAF 225
L+ + N+ + F +I + L TL L K P GK ++F F
Sbjct: 497 LVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIF 556
Query: 226 NGEFKNKAFALEV 238
NGEFK+K F +++
Sbjct: 557 NGEFKHKLFRIKI 569
>gi|88501736 DnaJ (Hsp40) homolog, subfamily B, member 2 isoform a
[Homo sapiens]
Length = 277
Score = 29.3 bits (64), Expect = 4.5
Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 8/53 (15%)
Query: 192 DDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQ 244
DD+KK Y L W PD P+N+ +FK A A EV+ H+
Sbjct: 17 DDIKK---AYRRKALQWH-----PDKNPDNKEFAEKKFKEVAEAYEVLSDKHK 61
>gi|27151736 DnaJ (Hsp40) homolog, subfamily B, member 2 isoform b
[Homo sapiens]
Length = 324
Score = 29.3 bits (64), Expect = 4.5
Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 8/53 (15%)
Query: 192 DDVKKFKPGYLEATLNWFRLYKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQ 244
DD+KK Y L W PD P+N+ +FK A A EV+ H+
Sbjct: 17 DDIKK---AYRRKALQWH-----PDKNPDNKEFAEKKFKEVAEAYEVLSDKHK 61
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 28.5 bits (62), Expect = 7.7
Identities = 13/36 (36%), Positives = 19/36 (52%)
Query: 81 KKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNP 116
K RND + N + + E + TN EI +K+P P
Sbjct: 2383 KMVRNDMFYNHYPYVPETEQETNVASEIPSKQPETP 2418
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,955,824
Number of Sequences: 37866
Number of extensions: 540842
Number of successful extensions: 1318
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1304
Number of HSP's gapped (non-prelim): 16
length of query: 305
length of database: 18,247,518
effective HSP length: 102
effective length of query: 203
effective length of database: 14,385,186
effective search space: 2920192758
effective search space used: 2920192758
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.