Search of human proteins with 7706671

Search of human proteins with 7706671

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens]
         (626 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens]       1237   0.0  
gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo sap...   395   e-110
gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo sap...   395   e-110
gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo sap...   395   e-110
gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo sap...   395   e-110
gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo sapi...   373   e-103
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       69   1e-11
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       69   1e-11
gi|224809432 transmembrane and tetratricopeptide repeat containi...    50   6e-06
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]           47   4e-05
gi|83415184 transmembrane and tetratricopeptide repeat containin...    44   4e-04
gi|238859655 tetratricopeptide repeat domain 31 [Homo sapiens]         44   6e-04
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         44   6e-04
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...    43   8e-04
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...    43   8e-04
gi|118766328 transmembrane and tetratricopeptide repeat containi...    43   8e-04
gi|118766330 transmembrane and tetratricopeptide repeat containi...    43   8e-04
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform...    41   0.003
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     40   0.005
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ...    40   0.005
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ...    40   0.006
gi|31542980 interferon-induced protein with tetratricopeptide re...    39   0.011
gi|72534658 interferon-induced protein with tetratricopeptide re...    39   0.011
gi|27765087 calpastatin isoform c [Homo sapiens]                       39   0.011
gi|109637759 calpastatin isoform f [Homo sapiens]                      39   0.014
gi|22749211 transmembrane and tetratricopeptide repeat containin...    39   0.014
gi|6912398 general transcription factor IIIC, polypeptide 3, 102...    39   0.014
gi|56606133 tetratricopeptide repeat domain 32 [Homo sapiens]          38   0.025
gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens]          38   0.025
gi|109637771 calpastatin isoform l [Homo sapiens]                      38   0.032

>gi|7706671 peroxisomal biogenesis factor 5-like [Homo sapiens]
          Length = 626

 Score = 1237 bits (3201), Expect = 0.0
 Identities = 626/626 (100%), Positives = 626/626 (100%)

Query: 1   MYQGHMQKSKEQGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPL 60
           MYQGHMQKSKEQGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPL
Sbjct: 1   MYQGHMQKSKEQGYGKLSSDEDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEEKPL 60

Query: 61  LTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQ 120
           LTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQ
Sbjct: 61  LTMTSQLVNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQ 120

Query: 121 TQTKAKKSEPSSKTSSLKKKADGSDLISTDAEQRGQPLRVPETSSLDLDIQTQLEKWDDV 180
           TQTKAKKSEPSSKTSSLKKKADGSDLISTDAEQRGQPLRVPETSSLDLDIQTQLEKWDDV
Sbjct: 121 TQTKAKKSEPSSKTSSLKKKADGSDLISTDAEQRGQPLRVPETSSLDLDIQTQLEKWDDV 180

Query: 181 KFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVAP 240
           KFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVAP
Sbjct: 181 KFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNSESASELELVAP 240

Query: 241 TQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQ 300
           TQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQ
Sbjct: 241 TQARLTKEHRWGSALLSRNHSLEEEFERAKAAVESDTEFWDKMQAEWEEMARRNWISENQ 300

Query: 301 EAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDA 360
           EAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDA
Sbjct: 301 EAQNQVTISASEKGYYFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDA 360

Query: 361 EAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNW 420
           EAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNW
Sbjct: 361 EAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNW 420

Query: 421 IKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGL 480
           IKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGL
Sbjct: 421 IKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGL 480

Query: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540
           GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG
Sbjct: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540

Query: 541 FIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSL 600
           FIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSL
Sbjct: 541 FIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSL 600

Query: 601 MDQPELFQAANLGDLDVLLRAFNLDP 626
           MDQPELFQAANLGDLDVLLRAFNLDP
Sbjct: 601 MDQPELFQAANLGDLDVLLRAFNLDP 626


>gi|196259776 peroxisomal biogenesis factor 5 isoform d [Homo
           sapiens]
          Length = 639

 Score =  395 bits (1016), Expect = e-110
 Identities = 208/374 (55%), Positives = 272/374 (72%), Gaps = 15/374 (4%)

Query: 261 SLEEEFERAKAAVESDTEFWDKMQAEWEEMARRN-----WISENQEAQNQVTISASEKGY 315
           +L+ EFERAK+A+ESD +FWDK+QAE EEMA+R+     W+S+  +    +T +  +KGY
Sbjct: 269 ALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDD----LTSATYDKGY 324

Query: 316 YFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENEN 375
            F  ENP +D P  FEEGL+RL+EGDLP  +L  EAA+ QDP   EAWQ+LG TQAENE 
Sbjct: 325 QFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQ 384

Query: 376 EQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKK 435
           E  AI AL+RCLEL+P+N  ALMALAVS+TN   Q+ AC+ L++W++  P Y +LV   +
Sbjct: 385 ELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAE 444

Query: 436 ---GSPGL--TRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEF 490
              G  GL  ++R+  S +  S+   VKEL+L A   +   IDPD+Q GLGVLF+LSGE+
Sbjct: 445 EGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEY 504

Query: 491 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGI 550
           ++A+D F AAL+VRP DY LWN+LGATLANG++SEEAV AY RALE+QPG+IRSRYNLGI
Sbjct: 505 DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 564

Query: 551 SCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAA 610
           SCINLGA+REAV +FL AL++QRKSR  +     A+S NIW+ LR+ALS++ Q + + AA
Sbjct: 565 SCINLGAHREAVEHFLEALNMQRKSRGPRG-EGGAMSENIWSTLRLALSMLGQSDAYGAA 623

Query: 611 NLGDLDVLLRAFNL 624
           +  DL  LL  F L
Sbjct: 624 DARDLSTLLTMFGL 637


>gi|196259774 peroxisomal biogenesis factor 5 isoform d [Homo
           sapiens]
          Length = 639

 Score =  395 bits (1016), Expect = e-110
 Identities = 208/374 (55%), Positives = 272/374 (72%), Gaps = 15/374 (4%)

Query: 261 SLEEEFERAKAAVESDTEFWDKMQAEWEEMARRN-----WISENQEAQNQVTISASEKGY 315
           +L+ EFERAK+A+ESD +FWDK+QAE EEMA+R+     W+S+  +    +T +  +KGY
Sbjct: 269 ALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDD----LTSATYDKGY 324

Query: 316 YFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENEN 375
            F  ENP +D P  FEEGL+RL+EGDLP  +L  EAA+ QDP   EAWQ+LG TQAENE 
Sbjct: 325 QFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQ 384

Query: 376 EQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKK 435
           E  AI AL+RCLEL+P+N  ALMALAVS+TN   Q+ AC+ L++W++  P Y +LV   +
Sbjct: 385 ELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAE 444

Query: 436 ---GSPGL--TRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEF 490
              G  GL  ++R+  S +  S+   VKEL+L A   +   IDPD+Q GLGVLF+LSGE+
Sbjct: 445 EGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEY 504

Query: 491 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGI 550
           ++A+D F AAL+VRP DY LWN+LGATLANG++SEEAV AY RALE+QPG+IRSRYNLGI
Sbjct: 505 DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 564

Query: 551 SCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAA 610
           SCINLGA+REAV +FL AL++QRKSR  +     A+S NIW+ LR+ALS++ Q + + AA
Sbjct: 565 SCINLGAHREAVEHFLEALNMQRKSRGPRG-EGGAMSENIWSTLRLALSMLGQSDAYGAA 623

Query: 611 NLGDLDVLLRAFNL 624
           +  DL  LL  F L
Sbjct: 624 DARDLSTLLTMFGL 637


>gi|196259772 peroxisomal biogenesis factor 5 isoform c [Homo
           sapiens]
          Length = 602

 Score =  395 bits (1016), Expect = e-110
 Identities = 208/374 (55%), Positives = 272/374 (72%), Gaps = 15/374 (4%)

Query: 261 SLEEEFERAKAAVESDTEFWDKMQAEWEEMARRN-----WISENQEAQNQVTISASEKGY 315
           +L+ EFERAK+A+ESD +FWDK+QAE EEMA+R+     W+S+  +    +T +  +KGY
Sbjct: 232 ALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDD----LTSATYDKGY 287

Query: 316 YFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENEN 375
            F  ENP +D P  FEEGL+RL+EGDLP  +L  EAA+ QDP   EAWQ+LG TQAENE 
Sbjct: 288 QFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQ 347

Query: 376 EQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKK 435
           E  AI AL+RCLEL+P+N  ALMALAVS+TN   Q+ AC+ L++W++  P Y +LV   +
Sbjct: 348 ELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAE 407

Query: 436 ---GSPGL--TRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEF 490
              G  GL  ++R+  S +  S+   VKEL+L A   +   IDPD+Q GLGVLF+LSGE+
Sbjct: 408 EGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEY 467

Query: 491 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGI 550
           ++A+D F AAL+VRP DY LWN+LGATLANG++SEEAV AY RALE+QPG+IRSRYNLGI
Sbjct: 468 DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 527

Query: 551 SCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAA 610
           SCINLGA+REAV +FL AL++QRKSR  +     A+S NIW+ LR+ALS++ Q + + AA
Sbjct: 528 SCINLGAHREAVEHFLEALNMQRKSRGPRG-EGGAMSENIWSTLRLALSMLGQSDAYGAA 586

Query: 611 NLGDLDVLLRAFNL 624
           +  DL  LL  F L
Sbjct: 587 DARDLSTLLTMFGL 600


>gi|196259770 peroxisomal biogenesis factor 5 isoform a [Homo
           sapiens]
          Length = 654

 Score =  395 bits (1016), Expect = e-110
 Identities = 208/374 (55%), Positives = 272/374 (72%), Gaps = 15/374 (4%)

Query: 261 SLEEEFERAKAAVESDTEFWDKMQAEWEEMARRN-----WISENQEAQNQVTISASEKGY 315
           +L+ EFERAK+A+ESD +FWDK+QAE EEMA+R+     W+S+  +    +T +  +KGY
Sbjct: 284 ALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPWLSDYDD----LTSATYDKGY 339

Query: 316 YFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENEN 375
            F  ENP +D P  FEEGL+RL+EGDLP  +L  EAA+ QDP   EAWQ+LG TQAENE 
Sbjct: 340 QFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQ 399

Query: 376 EQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKK 435
           E  AI AL+RCLEL+P+N  ALMALAVS+TN   Q+ AC+ L++W++  P Y +LV   +
Sbjct: 400 ELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAE 459

Query: 436 ---GSPGL--TRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEF 490
              G  GL  ++R+  S +  S+   VKEL+L A   +   IDPD+Q GLGVLF+LSGE+
Sbjct: 460 EGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEY 519

Query: 491 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGI 550
           ++A+D F AAL+VRP DY LWN+LGATLANG++SEEAV AY RALE+QPG+IRSRYNLGI
Sbjct: 520 DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 579

Query: 551 SCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAA 610
           SCINLGA+REAV +FL AL++QRKSR  +     A+S NIW+ LR+ALS++ Q + + AA
Sbjct: 580 SCINLGAHREAVEHFLEALNMQRKSRGPRG-EGGAMSENIWSTLRLALSMLGQSDAYGAA 638

Query: 611 NLGDLDVLLRAFNL 624
           +  DL  LL  F L
Sbjct: 639 DARDLSTLLTMFGL 652


>gi|21361204 peroxisomal biogenesis factor 5 isoform b [Homo
           sapiens]
          Length = 631

 Score =  373 bits (957), Expect = e-103
 Identities = 202/374 (54%), Positives = 265/374 (70%), Gaps = 23/374 (6%)

Query: 261 SLEEEFERAKAAVESDTEFWDKMQAEWEEMARRN-----WISENQEAQNQVTISASEKGY 315
           +L+ EFERAK+A+E        +QAE EEMA+R+     W+S+  +    +T +  +KGY
Sbjct: 269 ALDMEFERAKSAIE--------LQAELEEMAKRDAEAHPWLSDYDD----LTSATYDKGY 316

Query: 316 YFHTENPFKDWPGAFEEGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENEN 375
            F  ENP +D P  FEEGL+RL+EGDLP  +L  EAA+ QDP   EAWQ+LG TQAENE 
Sbjct: 317 QFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQYLGTTQAENEQ 376

Query: 376 EQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKK 435
           E  AI AL+RCLEL+P+N  ALMALAVS+TN   Q+ AC+ L++W++  P Y +LV   +
Sbjct: 377 ELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAHLVTPAE 436

Query: 436 ---GSPGL--TRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEF 490
              G  GL  ++R+  S +  S+   VKEL+L A   +   IDPD+Q GLGVLF+LSGE+
Sbjct: 437 EGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGEY 496

Query: 491 NRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGI 550
           ++A+D F AAL+VRP DY LWN+LGATLANG++SEEAV AY RALE+QPG+IRSRYNLGI
Sbjct: 497 DKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGI 556

Query: 551 SCINLGAYREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPELFQAA 610
           SCINLGA+REAV +FL AL++QRKSR  +     A+S NIW+ LR+ALS++ Q + + AA
Sbjct: 557 SCINLGAHREAVEHFLEALNMQRKSRGPRG-EGGAMSENIWSTLRLALSMLGQSDAYGAA 615

Query: 611 NLGDLDVLLRAFNL 624
           +  DL  LL  F L
Sbjct: 616 DARDLSTLLTMFGL 629


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 64/225 (28%), Positives = 94/225 (41%), Gaps = 12/225 (5%)

Query: 348 FMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNT 407
           F   AI Q+P  AEA+  LG    E    Q AI   +  L L+P+ +   + LA +    
Sbjct: 67  FSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAA 126

Query: 408 GHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQ 467
           G  + A  A  + ++ NP   Y V+S  G+  L + + +       LE  K  YL+A   
Sbjct: 127 GDMEGAVQAYVSALQYNPDL-YCVRSDLGN--LLKALGR-------LEEAKACYLKAIET 176

Query: 468 NGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEA 527
             +       + LG +F+  GE   AI  F  A+T+ P     +  LG  L      + A
Sbjct: 177 QPNF--AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRA 234

Query: 528 VEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 572
           V AY RAL + P       NL       G    A+  +  A+ LQ
Sbjct: 235 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 61/261 (23%), Positives = 101/261 (38%), Gaps = 32/261 (12%)

Query: 339 EGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALM 398
           +G++ + I   E A+  DP   +A+  LG    E      A+ A  R L L PN+     
Sbjct: 194 QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG 253

Query: 399 ALAVSYTNTGHQQDACDALKNWIKQNP-------------KYKYLVKSKKGSPGLTRRMS 445
            LA  Y   G    A D  +  I+  P             K K  V   +       R+ 
Sbjct: 254 NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLC 313

Query: 446 KSPVDS-----------SVLEGVKELYLEAAHQNGDMIDPDL---QTGLGVLFHLSGEFN 491
            +  DS             +E    LY +A       + P+     + L  +    G+  
Sbjct: 314 PTHADSLNNLANIKREQGNIEEAVRLYRKALE-----VFPEFAAAHSNLASVLQQQGKLQ 368

Query: 492 RAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGIS 551
            A+  +  A+ + P     ++ +G TL      + A++ YTRA++I P F  +  NL   
Sbjct: 369 EALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASI 428

Query: 552 CINLGAYREAVSNFLTALSLQ 572
             + G   EA++++ TAL L+
Sbjct: 429 HKDSGNIPEAIASYRTALKLK 449



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 13/208 (6%)

Query: 383 LQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTR 442
           L R        +K    LA +Y+N G+       L+  I+    Y++ ++ K        
Sbjct: 61  LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH---YRHALRLKPDFIDGYI 117

Query: 443 RMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALT 502
            ++ + V +  +EG  + Y+ A   N D+    +++ LG L    G    A   +  A+ 
Sbjct: 118 NLAAALVAAGDMEGAVQAYVSALQYNPDLYC--VRSDLGNLLKALGRLEEAKACYLKAIE 175

Query: 503 VRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAV 562
            +P     W+ LG           A+  + +A+ + P F+ +  NLG        +  AV
Sbjct: 176 TQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAV 235

Query: 563 SNFLTALSLQRKSRNQQQVPHPAISGNI 590
           + +L ALSL           H  + GN+
Sbjct: 236 AAYLRALSLSPN--------HAVVHGNL 255



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 49/193 (25%), Positives = 81/193 (41%), Gaps = 15/193 (7%)

Query: 382 ALQRCLEL---QPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSP 438
           A + C++L   +P+N   L+ L+  +        +       IKQNP    L+     + 
Sbjct: 30  AERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNP----LLAEAYSNL 85

Query: 439 GLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFN 498
           G   +      +   L+   E Y  A     D ID  +     ++   +G+   A+ A+ 
Sbjct: 86  GNVYK------ERGQLQEAIEHYRHALRLKPDFIDGYINLAAALV--AAGDMEGAVQAYV 137

Query: 499 AALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAY 558
           +AL   P+ Y + + LG  L    R EEA   Y +A+E QP F  +  NLG      G  
Sbjct: 138 SALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEI 197

Query: 559 REAVSNFLTALSL 571
             A+ +F  A++L
Sbjct: 198 WLAIHHFEKAVTL 210


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 64/225 (28%), Positives = 94/225 (41%), Gaps = 12/225 (5%)

Query: 348 FMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNT 407
           F   AI Q+P  AEA+  LG    E    Q AI   +  L L+P+ +   + LA +    
Sbjct: 77  FSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAA 136

Query: 408 GHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQ 467
           G  + A  A  + ++ NP   Y V+S  G+  L + + +       LE  K  YL+A   
Sbjct: 137 GDMEGAVQAYVSALQYNPDL-YCVRSDLGN--LLKALGR-------LEEAKACYLKAIET 186

Query: 468 NGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEA 527
             +       + LG +F+  GE   AI  F  A+T+ P     +  LG  L      + A
Sbjct: 187 QPNF--AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRA 244

Query: 528 VEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 572
           V AY RAL + P       NL       G    A+  +  A+ LQ
Sbjct: 245 VAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 289



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 61/261 (23%), Positives = 101/261 (38%), Gaps = 32/261 (12%)

Query: 339 EGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALM 398
           +G++ + I   E A+  DP   +A+  LG    E      A+ A  R L L PN+     
Sbjct: 204 QGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG 263

Query: 399 ALAVSYTNTGHQQDACDALKNWIKQNP-------------KYKYLVKSKKGSPGLTRRMS 445
            LA  Y   G    A D  +  I+  P             K K  V   +       R+ 
Sbjct: 264 NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLC 323

Query: 446 KSPVDS-----------SVLEGVKELYLEAAHQNGDMIDPDL---QTGLGVLFHLSGEFN 491
            +  DS             +E    LY +A       + P+     + L  +    G+  
Sbjct: 324 PTHADSLNNLANIKREQGNIEEAVRLYRKALE-----VFPEFAAAHSNLASVLQQQGKLQ 378

Query: 492 RAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGIS 551
            A+  +  A+ + P     ++ +G TL      + A++ YTRA++I P F  +  NL   
Sbjct: 379 EALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASI 438

Query: 552 CINLGAYREAVSNFLTALSLQ 572
             + G   EA++++ TAL L+
Sbjct: 439 HKDSGNIPEAIASYRTALKLK 459



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 46/208 (22%), Positives = 83/208 (39%), Gaps = 13/208 (6%)

Query: 383 LQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTR 442
           L R        +K    LA +Y+N G+       L+  I+    Y++ ++ K        
Sbjct: 71  LDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEH---YRHALRLKPDFIDGYI 127

Query: 443 RMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALT 502
            ++ + V +  +EG  + Y+ A   N D+    +++ LG L    G    A   +  A+ 
Sbjct: 128 NLAAALVAAGDMEGAVQAYVSALQYNPDLYC--VRSDLGNLLKALGRLEEAKACYLKAIE 185

Query: 503 VRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAV 562
            +P     W+ LG           A+  + +A+ + P F+ +  NLG        +  AV
Sbjct: 186 TQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAV 245

Query: 563 SNFLTALSLQRKSRNQQQVPHPAISGNI 590
           + +L ALSL           H  + GN+
Sbjct: 246 AAYLRALSLSPN--------HAVVHGNL 265



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 53/212 (25%), Positives = 88/212 (41%), Gaps = 17/212 (8%)

Query: 365 FLGITQAENENEQAAI--VALQRCLEL---QPNNLKALMALAVSYTNTGHQQDACDALKN 419
           F G+ +  +   QA     A + C++L   +P+N   L+ L+  +        +      
Sbjct: 21  FQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTL 80

Query: 420 WIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTG 479
            IKQNP    L+     + G   +      +   L+   E Y  A     D ID  +   
Sbjct: 81  AIKQNP----LLAEAYSNLGNVYK------ERGQLQEAIEHYRHALRLKPDFIDGYINLA 130

Query: 480 LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQP 539
             ++   +G+   A+ A+ +AL   P+ Y + + LG  L    R EEA   Y +A+E QP
Sbjct: 131 AALV--AAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQP 188

Query: 540 GFIRSRYNLGISCINLGAYREAVSNFLTALSL 571
            F  +  NLG      G    A+ +F  A++L
Sbjct: 189 NFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTL 220


>gi|224809432 transmembrane and tetratricopeptide repeat containing
           3 [Homo sapiens]
          Length = 914

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 27/88 (30%), Positives = 45/88 (51%)

Query: 484 FHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIR 543
           FH + ++      F +AL V   +  LWN +G  L N    E A++ + +A  +QP  I 
Sbjct: 422 FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIG 481

Query: 544 SRYNLGISCINLGAYREAVSNFLTALSL 571
           +  N+G +  NL   +EA  +++ A SL
Sbjct: 482 AHMNVGRTYKNLNRTKEAEESYMMAKSL 509



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 50/230 (21%), Positives = 92/230 (40%), Gaps = 32/230 (13%)

Query: 347 LFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTN 406
           LFM +A+  +  +A+ W  +G      +N + A+    +   +QP+++ A M +  +Y N
Sbjct: 434 LFM-SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKN 492

Query: 407 TGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAH 466
               ++A ++   ++        ++  KK +  +        ++ + L    E  LE A 
Sbjct: 493 LNRTKEAEES---YMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEAD 549

Query: 467 QNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEE 526
           Q                             +  A+++RP+    +   G  L   ++  +
Sbjct: 550 Q----------------------------LYRQAISMRPDFKQAYISRGELLLKMNKPLK 581

Query: 527 AVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSR 576
           A EAY +ALE+        YNL I  I L    EA+ NF  AL L  K +
Sbjct: 582 AKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHK 631



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 18/75 (24%), Positives = 40/75 (53%)

Query: 353 ILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQD 412
           I ++P DA  +  LG+   +++ +  A + +++ ++LQ +   AL  LA+ Y+ T  +  
Sbjct: 661 INEEPLDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELK 720

Query: 413 ACDALKNWIKQNPKY 427
           A   L+  ++  P +
Sbjct: 721 ALPILEELLRYYPDH 735



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 34/175 (19%), Positives = 66/175 (37%), Gaps = 23/175 (13%)

Query: 419 NWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQT 478
           +W  +   +   +K  K +  L   +  +  +    E   + +L+A H   D I   +  
Sbjct: 427 DWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNV 486

Query: 479 GLGVLFHLSGEFNRAIDAFNA-----------------ALTVRPEDYSLWNRLGATL-AN 520
           G           NR  +A  +                 A  + P   +++  L   + AN
Sbjct: 487 G-----RTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRAN 541

Query: 521 GDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKS 575
             R EEA + Y +A+ ++P F ++  + G   + +    +A   +L AL L R +
Sbjct: 542 ESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNN 596



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 21/77 (27%), Positives = 34/77 (44%), Gaps = 3/77 (3%)

Query: 352 AILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGH-- 409
           A+  D  +A+ W  L I   E +    A+    R LEL P +  AL   A+    +G   
Sbjct: 589 ALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVK 648

Query: 410 -QQDACDALKNWIKQNP 425
            + +A   L ++I + P
Sbjct: 649 LRPEARKRLLSYINEEP 665


>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
          Length = 1564

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 24/85 (28%), Positives = 46/85 (54%)

Query: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540
           G+ +  +G+ ++A+    AAL   P+D++ W  LG    +      A++++T+A E+ P 
Sbjct: 571 GLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPE 630

Query: 541 FIRSRYNLGISCINLGAYREAVSNF 565
            I S + +      LG Y+EAV+ +
Sbjct: 631 SIYSVFKVAAIQQILGKYKEAVAQY 655



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 33/133 (24%), Positives = 56/133 (42%), Gaps = 4/133 (3%)

Query: 333 GLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPN 392
           GL  LK G     +  ++AA+  DP D   W+ LG           A+ +  +  EL P 
Sbjct: 571 GLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPE 630

Query: 393 NLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSS 452
           ++ ++  +A      G  ++A    +  IK+   Y   V + KG       M+K+ +   
Sbjct: 631 SIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDY---VPALKGLGECHLMMAKAAL-VD 686

Query: 453 VLEGVKELYLEAA 465
            L+G    Y+E A
Sbjct: 687 YLDGKAVDYIEKA 699



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 19/60 (31%), Positives = 29/60 (48%)

Query: 350 EAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGH 409
           +  + Q+  +  AW F+G+  AE E    A  A ++  EL+P+ L A   LA  Y    H
Sbjct: 30  KTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGLANLYEKYNH 89



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 13/51 (25%), Positives = 25/51 (49%)

Query: 489 EFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQP 539
           E+  A+      L     +Y+ W  +G   A  ++ ++A  AY +A E++P
Sbjct: 21  EYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEP 71


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
           [Homo sapiens]
          Length = 774

 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 47/194 (24%), Positives = 77/194 (39%), Gaps = 15/194 (7%)

Query: 384 QRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRR 443
           QR L+L P + +AL  L     +   +++A   LK+ IK  P++     S          
Sbjct: 430 QRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSS---------- 479

Query: 444 MSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTV 503
           ++    +    +  +E+Y        D    DL    GV    +G   +A+  +  A+ +
Sbjct: 480 LASLLAEQERFKEAEEIYQTGIKNCPD--SSDLHNNYGVFLVDTGLPEKAVAHYQQAIKL 537

Query: 504 RPEDYSLWNRLGATLANGDRSEEAVEAYTRALEI-QPGFIRSRYNLGISCINLGAYREAV 562
            P  +     LG    +   +  A E Y RAL++     I S   LG    N G Y EA+
Sbjct: 538 SPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILS--PLGALYYNTGRYEEAL 595

Query: 563 SNFLTALSLQRKSR 576
             +  A +LQ   R
Sbjct: 596 QIYQEAAALQPSQR 609



 Score = 33.9 bits (76), Expect = 0.46
 Identities = 26/101 (25%), Positives = 49/101 (48%), Gaps = 4/101 (3%)

Query: 480 LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRS----EEAVEAYTRAL 535
           L  ++      ++A+DA + AL ++P+D  + + L  T  N  R     ++A E+Y  A+
Sbjct: 649 LSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAV 708

Query: 536 EIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSR 576
           ++ P   ++  N+G      G Y  A + +  AL L   S+
Sbjct: 709 QLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSK 749



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 3/62 (4%)

Query: 488 GEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYN 547
           G    AI  +  AL + P   S  N LG    +   + EA   Y RAL++ P   R+ +N
Sbjct: 389 GRNKEAIYHYRTALKLYPRHASALNNLGTLTRD---TAEAKMYYQRALQLHPQHNRALFN 445

Query: 548 LG 549
           LG
Sbjct: 446 LG 447



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 15/63 (23%), Positives = 32/63 (50%)

Query: 353 ILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQD 412
           + ++ G  E ++ L    ++ EN   A+ A+ + L+L+P + K +  L  +  N   +Q+
Sbjct: 636 VSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQN 695

Query: 413 ACD 415
             D
Sbjct: 696 LLD 698


>gi|238859655 tetratricopeptide repeat domain 31 [Homo sapiens]
          Length = 519

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 35/149 (23%), Positives = 63/149 (42%), Gaps = 6/149 (4%)

Query: 421 IKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGL 480
           + Q P+ + L   K G    +    + P  S  ++    L   A  Q+ ++        L
Sbjct: 258 LNQEPQGRGLALQKMGQEEESPPREERPQQSPKVQASPGLLAAALQQSQELAK------L 311

Query: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540
           G  F  +G ++ A+  F  AL + P+D+ L+           +   A+     AL ++PG
Sbjct: 312 GTSFAQNGFYHEAVVLFTQALKLNPQDHRLFGNRSFCHERLGQPAWALADAQVALTLRPG 371

Query: 541 FIRSRYNLGISCINLGAYREAVSNFLTAL 569
           + R  + LG + + L  +REA + F   L
Sbjct: 372 WPRGLFRLGKALMGLQRFREAAAVFQETL 400


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 62/300 (20%), Positives = 115/300 (38%), Gaps = 33/300 (11%)

Query: 339 EGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALM 398
           +GD    I+    A+  DP +   +        + +    A+    +   L P   KA  
Sbjct: 71  DGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYF 130

Query: 399 ALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVK 458
              V+    G   DA  A  + + Q+PK   L+       G+     KSP+  S+    +
Sbjct: 131 RQGVALQYLGRHADALAAFASGLAQDPKSLQLLV------GMVEAAMKSPMRDSL----E 180

Query: 459 ELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTV-------RPEDYSLW 511
             Y +      D     + + +G     +G    ++    AAL +       R   +S  
Sbjct: 181 PTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSAL 240

Query: 512 NRLGATLANGDRSEEAVEA---YTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTA 568
           +    +L N ++S   ++      + L  Q G  R+  NLG +  + G YREA++N    
Sbjct: 241 SSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQ 300

Query: 569 LSLQRKSRNQQQVPHPAIS-GNIWAALR------------IALSLMDQPELFQAANLGDL 615
           L L  K ++++       S G+++ A+             + L+   + EL +A  LG++
Sbjct: 301 LVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNM 360



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 61/261 (23%), Positives = 101/261 (38%), Gaps = 28/261 (10%)

Query: 354 LQD-PGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQD 412
           LQD  G+ +    LG       N Q A+   ++ L L   +L   ++ A +Y N G    
Sbjct: 627 LQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALA-KDLHDKLSQAKAYCNLGL--- 682

Query: 413 ACDALKNWIKQNPKYKYLV---KSKKGSPGLTRRMSKSP---VDSSVLEGVKELY---LE 463
           A  AL N+ K     KYL+   +S   S    R +       +    + G  + Y   L 
Sbjct: 683 AFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLG 742

Query: 464 AAHQNGDM-IDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVR------PEDYSLWNRLGA 516
            AHQ  D  ++      LG  + +  ++++A+      L V       P +      L A
Sbjct: 743 LAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAA 802

Query: 517 TLANGDRSEEAVEAYTRALEI-----QPGFIRSRY-NLGISCINLGAYREAVSNFLTALS 570
                 +   A + Y   L++      P      Y N+GI+ +N+    EA+  F   L+
Sbjct: 803 VYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLA 862

Query: 571 -LQRKSRNQQQVPHPAISGNI 590
            LQ+ S N+  +      GN+
Sbjct: 863 MLQQLSGNESVLDRGRAYGNL 883


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
           sapiens]
          Length = 830

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 49/227 (21%), Positives = 86/227 (37%), Gaps = 18/227 (7%)

Query: 356 DPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACD 415
           D    EAW   G   +       AI   QR +++ PN   A   L   +  T     A  
Sbjct: 569 DKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALA 628

Query: 416 ALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPD 475
             +N I+ NP++     +  G   +  +  K          + E++ + A      I+P 
Sbjct: 629 CFRNAIRVNPRH---YNAWYGLGMIYYKQEKF--------SLAEMHFQKALD----INPQ 673

Query: 476 ---LQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYT 532
              L   +GV+ H   +  +A+D  N A+ + P++        + L   ++ + A++   
Sbjct: 674 SSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELE 733

Query: 533 RALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQ 579
              +I P      + +G     LG    A+ NF  A+ L  K  N Q
Sbjct: 734 ELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQ 780


>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
           sapiens]
          Length = 824

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 49/227 (21%), Positives = 86/227 (37%), Gaps = 18/227 (7%)

Query: 356 DPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACD 415
           D    EAW   G   +       AI   QR +++ PN   A   L   +  T     A  
Sbjct: 563 DKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALA 622

Query: 416 ALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPD 475
             +N I+ NP++     +  G   +  +  K          + E++ + A      I+P 
Sbjct: 623 CFRNAIRVNPRH---YNAWYGLGMIYYKQEKF--------SLAEMHFQKALD----INPQ 667

Query: 476 ---LQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYT 532
              L   +GV+ H   +  +A+D  N A+ + P++        + L   ++ + A++   
Sbjct: 668 SSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELE 727

Query: 533 RALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQ 579
              +I P      + +G     LG    A+ NF  A+ L  K  N Q
Sbjct: 728 ELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQ 774


>gi|118766328 transmembrane and tetratricopeptide repeat containing
           4 isoform 2 [Homo sapiens]
          Length = 741

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 27/87 (31%), Positives = 43/87 (49%)

Query: 488 GEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYN 547
           G    AI  +  A+ + P+     N LG  L   +  +EA E  + A++IQP F  +  N
Sbjct: 496 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 555

Query: 548 LGISCINLGAYREAVSNFLTALSLQRK 574
           LGI   +L  +  A  ++ TA+  +RK
Sbjct: 556 LGIVQNSLKRFEAAEQSYRTAIKHRRK 582



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 54/238 (22%), Positives = 91/238 (38%), Gaps = 22/238 (9%)

Query: 337 LKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKA 396
           L+ G+         +A+   P +A+    +G   A+  N+ AAI   +  + L P  + A
Sbjct: 459 LRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHA 518

Query: 397 LMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSV--L 454
           +  L          Q+A + L   ++  P +                M+   V +S+   
Sbjct: 519 MNNLGNILKERNELQEAEELLSLAVQIQPDFA------------AAWMNLGIVQNSLKRF 566

Query: 455 EGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNA---ALTVRPEDYSLW 511
           E  ++ Y  A         PD    LG L+    + NR +DA NA   A  ++PE    W
Sbjct: 567 EAAEQSYRTAIKHRRKY--PDCYYNLGRLY---ADLNRHVDALNAWRNATVLKPEHSLAW 621

Query: 512 NRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTAL 569
           N +   L N     +A      ALE+ P      ++L         Y+E+ + FL A+
Sbjct: 622 NNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAI 679



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 26/112 (23%), Positives = 49/112 (43%), Gaps = 2/112 (1%)

Query: 461 YLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLAN 520
           Y EA   N   +       LG +     E   A +  + A+ ++P+  + W  LG    +
Sbjct: 505 YREAVRLNPKYVHA--MNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNS 562

Query: 521 GDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 572
             R E A ++Y  A++ +  +    YNLG    +L  + +A++ +  A  L+
Sbjct: 563 LKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLK 614


>gi|118766330 transmembrane and tetratricopeptide repeat containing
           4 isoform 1 [Homo sapiens]
          Length = 760

 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 27/87 (31%), Positives = 43/87 (49%)

Query: 488 GEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYN 547
           G    AI  +  A+ + P+     N LG  L   +  +EA E  + A++IQP F  +  N
Sbjct: 515 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 574

Query: 548 LGISCINLGAYREAVSNFLTALSLQRK 574
           LGI   +L  +  A  ++ TA+  +RK
Sbjct: 575 LGIVQNSLKRFEAAEQSYRTAIKHRRK 601



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 54/238 (22%), Positives = 91/238 (38%), Gaps = 22/238 (9%)

Query: 337 LKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKA 396
           L+ G+         +A+   P +A+    +G   A+  N+ AAI   +  + L P  + A
Sbjct: 478 LRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHA 537

Query: 397 LMALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSV--L 454
           +  L          Q+A + L   ++  P +                M+   V +S+   
Sbjct: 538 MNNLGNILKERNELQEAEELLSLAVQIQPDFA------------AAWMNLGIVQNSLKRF 585

Query: 455 EGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNA---ALTVRPEDYSLW 511
           E  ++ Y  A         PD    LG L+    + NR +DA NA   A  ++PE    W
Sbjct: 586 EAAEQSYRTAIKHRRKY--PDCYYNLGRLY---ADLNRHVDALNAWRNATVLKPEHSLAW 640

Query: 512 NRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTAL 569
           N +   L N     +A      ALE+ P      ++L         Y+E+ + FL A+
Sbjct: 641 NNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAI 698



 Score = 34.3 bits (77), Expect = 0.35
 Identities = 26/112 (23%), Positives = 49/112 (43%), Gaps = 2/112 (1%)

Query: 461 YLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLAN 520
           Y EA   N   +       LG +     E   A +  + A+ ++P+  + W  LG    +
Sbjct: 524 YREAVRLNPKYVHA--MNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNS 581

Query: 521 GDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSLQ 572
             R E A ++Y  A++ +  +    YNLG    +L  + +A++ +  A  L+
Sbjct: 582 LKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLK 633


>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
           [Homo sapiens]
          Length = 494

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 25/100 (25%), Positives = 46/100 (46%)

Query: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540
           G  ++   ++N A + +  A+ + P++ S +    ATL    R  EA+    +++ +   
Sbjct: 35  GNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDS 94

Query: 541 FIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQQ 580
           F+R     G   ++LG    A  +F  AL L  K+   QQ
Sbjct: 95  FVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQ 134


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 44/228 (19%), Positives = 76/228 (33%), Gaps = 60/228 (26%)

Query: 379 AIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNP-KYKYLVKSKKGS 437
           AI   ++ +E  P N + L  L + Y   G  Q A + L N +  +P  YK ++ +    
Sbjct: 187 AIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAA---- 242

Query: 438 PGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAF 497
                                                      G +    G+F+ A+  +
Sbjct: 243 -------------------------------------------GSMMQTHGDFDVALTKY 259

Query: 498 NAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGA 557
                  PE   LWN +G       +   A+    RA  + P   +  YNLG+  + +  
Sbjct: 260 RVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQ 319

Query: 558 YREAVSNFLTALSLQRKSRNQQQVPHPAISGNIWAALRIALSLMDQPE 605
           Y  A      A++ Q K             G ++  L +AL+ ++  E
Sbjct: 320 YASAFHFLSAAINFQPK------------MGELYMLLAVALTNLEDIE 355



 Score = 36.2 bits (82), Expect = 0.093
 Identities = 20/92 (21%), Positives = 40/92 (43%)

Query: 482 VLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGF 541
           ++F L G    +++ F     + P+      ++  +L    + + A+E Y  A ++    
Sbjct: 75  LIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKD 134

Query: 542 IRSRYNLGISCINLGAYREAVSNFLTALSLQR 573
               +NLG+  I L  + +A      AL+L R
Sbjct: 135 WEISHNLGVCYIYLKQFNKAQDQLHNALNLNR 166


>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
           sapiens]
          Length = 860

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 42/212 (19%), Positives = 79/212 (37%), Gaps = 25/212 (11%)

Query: 374 ENEQAAIVALQRCLELQPNNLKALMALAVSYTNTGHQQDACDALKNWIKQNPK------- 426
           +N + A+  L R + L+P+  +     A   +  G   +A + L   I+  P        
Sbjct: 196 KNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHR 255

Query: 427 ----------------YKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGD 470
                           ++  ++  K  P        +     +L+   E + EA  Q  D
Sbjct: 256 GTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVD 315

Query: 471 MIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEA 530
            ID      LG  +   G F  A ++F  AL +           G  L +    +EA++ 
Sbjct: 316 FIDA--YKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKN 373

Query: 531 YTRALEIQPGFIRSRYNLGISCINLGAYREAV 562
           + R L+++P     +Y  G+S + +G + E +
Sbjct: 374 FKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGI 405



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 24/93 (25%), Positives = 44/93 (47%)

Query: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540
           G L+ +S ++  A + F  +L +           G T  +    +EA+E++  AL+ +  
Sbjct: 256 GTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVD 315

Query: 541 FIRSRYNLGISCINLGAYREAVSNFLTALSLQR 573
           FI +  +LG +   LG +  A  +F  AL L +
Sbjct: 316 FIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 348


>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
           sapiens]
          Length = 807

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 28/110 (25%), Positives = 49/110 (44%), Gaps = 2/110 (1%)

Query: 453 VLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWN 512
           +L+   E + EA  Q  D ID      LG  +   G F  A ++F  AL +         
Sbjct: 245 LLKEAIESFKEALKQKVDFIDA--YKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQ 302

Query: 513 RLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAV 562
             G  L +    +EA++ + R L+++P     +Y  G+S + +G + E +
Sbjct: 303 LRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGI 352



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 24/93 (25%), Positives = 44/93 (47%)

Query: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540
           G L+ +S ++  A + F  +L +           G T  +    +EA+E++  AL+ +  
Sbjct: 203 GTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVD 262

Query: 541 FIRSRYNLGISCINLGAYREAVSNFLTALSLQR 573
           FI +  +LG +   LG +  A  +F  AL L +
Sbjct: 263 FIDAYKSLGQAYRELGNFEAATESFQKALLLNQ 295


>gi|31542980 interferon-induced protein with tetratricopeptide
           repeats 3 [Homo sapiens]
          Length = 490

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 36/163 (22%), Positives = 64/163 (39%), Gaps = 37/163 (22%)

Query: 367 GITQAENENEQAAIVALQRCLELQPNNLKALMALAVS---YTNTGHQQDACDALKNWIKQ 423
           G TQ +    + A V  ++ LE +PNN +    LA++     N   +Q + D LK  I+ 
Sbjct: 143 GWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIEL 202

Query: 424 NPKYKY-----------LVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMI 472
           +P  +Y           + K  +G   +   + KSP  + VL    + Y           
Sbjct: 203 SPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFY----------- 251

Query: 473 DPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLG 515
                          G+ ++AI+ F   L   P +  L++++G
Sbjct: 252 ------------RRKGDLDKAIELFQRVLESTPNNGYLYHQIG 282


>gi|72534658 interferon-induced protein with tetratricopeptide
           repeats 3 [Homo sapiens]
          Length = 490

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 36/163 (22%), Positives = 64/163 (39%), Gaps = 37/163 (22%)

Query: 367 GITQAENENEQAAIVALQRCLELQPNNLKALMALAVS---YTNTGHQQDACDALKNWIKQ 423
           G TQ +    + A V  ++ LE +PNN +    LA++     N   +Q + D LK  I+ 
Sbjct: 143 GWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIEL 202

Query: 424 NPKYKY-----------LVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMI 472
           +P  +Y           + K  +G   +   + KSP  + VL    + Y           
Sbjct: 203 SPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFY----------- 251

Query: 473 DPDLQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLG 515
                          G+ ++AI+ F   L   P +  L++++G
Sbjct: 252 ------------RRKGDLDKAIELFQRVLESTPNNGYLYHQIG 282


>gi|27765087 calpastatin isoform c [Homo sapiens]
          Length = 430

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 41/148 (27%), Positives = 63/148 (42%), Gaps = 17/148 (11%)

Query: 15  GKLSSD-EDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEE------KPLLTMTSQL 67
           GK  +D ED + ++D+ + K      + +    + IP +   EE      KPLL      
Sbjct: 165 GKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP----- 219

Query: 68  VNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQTQTKAKK 127
               +ES+  L P  +DFL +  SE  + P  +++           +SE VSQT     +
Sbjct: 220 ----KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 275

Query: 128 S-EPSSKTSSLKKKADGSDLISTDAEQR 154
           +  P   TSS K   D  D +S    QR
Sbjct: 276 AGAPPRDTSSDKDLDDALDKLSDSLGQR 303


>gi|109637759 calpastatin isoform f [Homo sapiens]
          Length = 750

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 30/118 (25%), Positives = 51/118 (43%), Gaps = 4/118 (3%)

Query: 115 SEPVSQTQTKAKKSEPSSKTSSLKKKA---DGSDLISTDAEQRGQPLRVPETSSLDLDIQ 171
           S  ++ T+TKA K+EP  K+ S K K+     SD  S DA  +    R  E    +   +
Sbjct: 81  SSSMNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTE 140

Query: 172 TQLEKWDDVKFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNS 229
            + +  D +   G+ +  G      K    +   K L  +    S+P+   GKS +++
Sbjct: 141 PKTKPQDMISAGGE-SVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 197



 Score = 36.6 bits (83), Expect = 0.071
 Identities = 40/149 (26%), Positives = 62/149 (41%), Gaps = 18/149 (12%)

Query: 15  GKLSSD-EDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEE------KPLLTMTSQL 67
           GK  +D ED + ++D+ + K      + +    + IP +   EE      KPLL      
Sbjct: 484 GKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP----- 538

Query: 68  VNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQT--QTKA 125
               +ES+  L P  +DFL +  SE  + P  +++           +SE VSQT   T  
Sbjct: 539 ----KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 594

Query: 126 KKSEPSSKTSSLKKKADGSDLISTDAEQR 154
             + P   + S K   D  D +S    QR
Sbjct: 595 AGAPPRDTSQSDKDLDDALDKLSDSLGQR 623


>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
           [Homo sapiens]
          Length = 836

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 39/165 (23%), Positives = 62/165 (37%), Gaps = 13/165 (7%)

Query: 416 ALKNWIKQNPKYKYLVKSKKGSPGLTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPD 475
           A++N   QN +  Y    K         +       S +   +  Y  A +   +M D  
Sbjct: 471 AIRNGDWQNEEMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMAD-- 528

Query: 476 LQTGLGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRAL 535
           +   LG+L   +  F  A+  +  A+  RP   S +   G  L N  R+EEA   + +  
Sbjct: 529 MLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588

Query: 536 EIQPGFIRS-----------RYNLGISCINLGAYREAVSNFLTAL 569
           EI    ++             YNLG      G Y EA+S +  A+
Sbjct: 589 EIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAI 633


>gi|6912398 general transcription factor IIIC, polypeptide 3, 102kDa
           [Homo sapiens]
          Length = 886

 Score = 38.9 bits (89), Expect = 0.014
 Identities = 33/162 (20%), Positives = 69/162 (42%), Gaps = 15/162 (9%)

Query: 339 EGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQPNNLKALM 398
           +GD+  ++ F   A   +P D E W  L     E +N + AI    + L+ +P N++ L 
Sbjct: 196 QGDMEKSLQFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEPTNVRYLW 255

Query: 399 ALAVSYTNTGHQQDACDALKNWIKQNPKYKYLVKSKKGSPG-----LTRRMSKSPVDSSV 453
             +  Y   G  + A D           Y+ ++     S G     L R M+KS  +++ 
Sbjct: 256 ERSSLYEQMGDHKMAMDG----------YRRILNLLSPSDGERFMQLARDMAKSYYEAND 305

Query: 454 LEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAID 495
           +     +  EA  ++  ++  +       L+  + ++++A++
Sbjct: 306 VTSAINIIDEAFSKHQGLVSMEDVNIAAELYISNKQYDKALE 347



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 21/100 (21%), Positives = 45/100 (45%)

Query: 480 LGVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQP 539
           L +++   G+  +++     A  + P D   W RL       D  ++A+  YT+AL+ +P
Sbjct: 189 LAMIYEDQGDMEKSLQFELIAAHLNPSDTEEWVRLAEMSLEQDNIKQAIFCYTKALKYEP 248

Query: 540 GFIRSRYNLGISCINLGAYREAVSNFLTALSLQRKSRNQQ 579
             +R  +        +G ++ A+  +   L+L   S  ++
Sbjct: 249 TNVRYLWERSSLYEQMGDHKMAMDGYRRILNLLSPSDGER 288



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 6/126 (4%)

Query: 440 LTRRMSKSPVDSSVLEGVKELYLEAAHQNGDMIDPDLQTGLGVLFHLSGEFNRAIDAFNA 499
           +T ++    V  ++LE +  L      QN + +  DL   +   F   GE+N A+   +A
Sbjct: 388 ITVKLMVCLVHLNILEPLNPLLTTLVEQNPEDMG-DLYLDVAEAFLDVGEYNSALPLLSA 446

Query: 500 ALTVRPEDYSL---WNRLGATLANGDRSEEAVEAYTRALEIQPGFIRSRYNLGISCINLG 556
              V  E Y+L   W R    L      E A E+Y + +++ P  + +R +L      LG
Sbjct: 447 L--VCSERYNLAVVWLRHAECLKALGYMERAAESYGKVVDLAPLHLDARISLSTLQQQLG 504

Query: 557 AYREAV 562
              +A+
Sbjct: 505 QPEKAL 510


>gi|56606133 tetratricopeptide repeat domain 32 [Homo sapiens]
          Length = 151

 Score = 38.1 bits (87), Expect = 0.025
 Identities = 18/46 (39%), Positives = 27/46 (58%)

Query: 526 EAVEAYTRALEIQPGFIRSRYNLGISCINLGAYREAVSNFLTALSL 571
           EA++ YT A+E+QP F    YN G+    LG + +A+ +F   L L
Sbjct: 76  EAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVLDL 121



 Score = 29.6 bits (65), Expect = 8.7
 Identities = 15/61 (24%), Positives = 31/61 (50%)

Query: 481 GVLFHLSGEFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPG 540
           G + +   +F  A+D + +A+ V+P     +   G  L      ++A+E + + L++ PG
Sbjct: 65  GQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVLDLNPG 124

Query: 541 F 541
           F
Sbjct: 125 F 125


>gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens]
          Length = 843

 Score = 38.1 bits (87), Expect = 0.025
 Identities = 24/93 (25%), Positives = 41/93 (44%)

Query: 332 EGLKRLKEGDLPVTILFMEAAILQDPGDAEAWQFLGITQAENENEQAAIVALQRCLELQP 391
           + L  L+  +    +   E ++  +P     W  LG      E+ Q +  A QRC+ L+P
Sbjct: 533 KALLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEP 592

Query: 392 NNLKALMALAVSYTNTGHQQDACDALKNWIKQN 424
           +N +A   L+ SY     +  A   L+  +K N
Sbjct: 593 DNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCN 625



 Score = 33.1 bits (74), Expect = 0.79
 Identities = 18/74 (24%), Positives = 33/74 (44%), Gaps = 1/74 (1%)

Query: 483 LFHLSG-EFNRAIDAFNAALTVRPEDYSLWNRLGATLANGDRSEEAVEAYTRALEIQPGF 541
           L HL   EF   ++ F  ++ + P    +W  LG      +  + + +A+ R + ++P  
Sbjct: 535 LLHLRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDN 594

Query: 542 IRSRYNLGISCINL 555
             +  NL  S I L
Sbjct: 595 AEAWNNLSTSYIRL 608


>gi|109637771 calpastatin isoform l [Homo sapiens]
          Length = 654

 Score = 37.7 bits (86), Expect = 0.032
 Identities = 29/115 (25%), Positives = 50/115 (43%), Gaps = 4/115 (3%)

Query: 118 VSQTQTKAKKSEPSSKTSSLKKKA---DGSDLISTDAEQRGQPLRVPETSSLDLDIQTQL 174
           ++ T+TKA K+EP  K+ S K K+     SD  S DA  +    R  E    +   + + 
Sbjct: 1   MNPTETKAVKTEPEKKSQSTKPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKT 60

Query: 175 EKWDDVKFHGDRNTKGHPMAERKSSSSRTGSKELLWSSEHRSQPELSGGKSALNS 229
           +  D +   G+ +  G      K    +   K L  +    S+P+   GKS +++
Sbjct: 61  KPQDMISAGGE-SVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDA 114



 Score = 36.6 bits (83), Expect = 0.071
 Identities = 40/149 (26%), Positives = 62/149 (41%), Gaps = 18/149 (12%)

Query: 15  GKLSSD-EDLEIIVDQKQGKGSRAADKAVAMVMKEIPREESAEE------KPLLTMTSQL 67
           GK  +D ED + ++D+ + K      + +    + IP +   EE      KPLL      
Sbjct: 388 GKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLP----- 442

Query: 68  VNEQQESRPLLSPSIDDFLCETKSEAIARPVTSNTAVLTTGLDLLDLSEPVSQT--QTKA 125
               +ES+  L P  +DFL +  SE  + P  +++           +SE VSQT   T  
Sbjct: 443 ----KESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQ 498

Query: 126 KKSEPSSKTSSLKKKADGSDLISTDAEQR 154
             + P   + S K   D  D +S    QR
Sbjct: 499 AGAPPRDTSQSDKDLDDALDKLSDSLGQR 527


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.127    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,671,576
Number of Sequences: 37866
Number of extensions: 980654
Number of successful extensions: 3356
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 3010
Number of HSP's gapped (non-prelim): 397
length of query: 626
length of database: 18,247,518
effective HSP length: 108
effective length of query: 518
effective length of database: 14,157,990
effective search space: 7333838820
effective search space used: 7333838820
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.