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Search of human proteins with 14042947
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
(367 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 747 0.0
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 481 e-136
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 254 7e-68
gi|14042966 testis-specific serine kinase 6 [Homo sapiens] 241 6e-64
gi|42734401 testis-specific serine kinase 4 [Homo sapiens] 224 1e-58
gi|116256471 SNF1-like kinase [Homo sapiens] 205 6e-53
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 199 3e-51
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 197 1e-50
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 191 9e-49
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 191 9e-49
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 191 9e-49
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 191 9e-49
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 191 9e-49
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 191 1e-48
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 189 4e-48
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 189 4e-48
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 189 4e-48
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 189 4e-48
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 187 2e-47
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 179 5e-45
gi|156105707 SNF related kinase [Homo sapiens] 174 9e-44
gi|156105705 SNF related kinase [Homo sapiens] 174 9e-44
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 172 6e-43
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 169 4e-42
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 168 8e-42
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 167 1e-41
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 165 7e-41
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 164 9e-41
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 159 4e-39
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 159 4e-39
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 747 bits (1928), Expect = 0.0
Identities = 367/367 (100%), Positives = 367/367 (100%)
Query: 1 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE 60
MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE
Sbjct: 1 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE 60
Query: 61 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL 120
IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL
Sbjct: 61 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL 120
Query: 121 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA 180
SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA
Sbjct: 121 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA 180
Query: 181 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH 240
YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH
Sbjct: 181 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH 240
Query: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP 300
LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP
Sbjct: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP 300
Query: 301 EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ 360
EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ
Sbjct: 301 EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ 360
Query: 361 PPETRAQ 367
PPETRAQ
Sbjct: 361 PPETRAQ 367
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 481 bits (1238), Expect = e-136
Identities = 241/353 (68%), Positives = 281/353 (79%), Gaps = 20/353 (5%)
Query: 1 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE 60
MDDA VL+++GY++GINLG+GSYAKVKSAYSERLKFNVA+KIIDRKK P DF+E+FLPRE
Sbjct: 1 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
Query: 61 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL 120
++ILA +NH SIIKTYEIFETS G++YI+MEL VQGDLLE IK +GALHED ARK F QL
Sbjct: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL 120
Query: 121 SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA 180
S A+KYCHDLD+VHRDLKC+NLLLDKDFNIKLSDF FSKRCLRD +GR+ LSKTFCGS A
Sbjct: 121 SSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAA 180
Query: 181 YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH 240
YAAPEVLQ IPYQPKVYDIWSLGVILYIMVCGSMPYDDS+I+KMLRIQKEHRV+FPRSK+
Sbjct: 181 YAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKN 240
Query: 241 LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQ-PKARGSPSVAINKEGESSRGTEPLWT 299
LT ECKDLIY MLQPDV++RLHIDEILSH W+Q PK + + S + +EGE E
Sbjct: 241 LTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAE---- 296
Query: 300 PEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTME 352
KL+ + +P +P+ K + Q +L P + ME
Sbjct: 297 ----------CKLDTKTGLRPDHRPDHK-----LGAKTQHRLLVVPENENRME 334
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 254 bits (650), Expect = 7e-68
Identities = 125/266 (46%), Positives = 185/266 (69%), Gaps = 5/266 (1%)
Query: 7 LKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAM 66
L GY LG +GEG+Y+KVK A+S++ + VAIK+ID+ P +F+++FLPRE++I+
Sbjct: 5 LLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRT 64
Query: 67 LNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKY 126
L+H +II+ YE+ E++ GK+ +VMELA GD+ + + G L E A+ F Q+ AI+Y
Sbjct: 65 LDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRY 124
Query: 127 CHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEV 186
CH V HRDLKC+N LL + FN+KL+DF F+K LS+TFCGS AYAAPEV
Sbjct: 125 CHGCGVAHRDLKCENALL-QGFNLKLTDFGFAKVL---PKSHRELSQTFCGSTAYAAPEV 180
Query: 187 LQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECK 246
LQGIP+ K D+WS+GV+LY+M+C S+P+DD++I KML Q++ V+FP ++ +C+
Sbjct: 181 LQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKML-WQQQKGVSFPTHLSISADCQ 239
Query: 247 DLIYHMLQPDVNRRLHIDEILSHCWM 272
DL+ +L+PD+ R I+E+ H W+
Sbjct: 240 DLLKRLLEPDMILRPSIEEVSWHPWL 265
>gi|14042966 testis-specific serine kinase 6 [Homo sapiens]
Length = 273
Score = 241 bits (616), Expect = 6e-64
Identities = 128/274 (46%), Positives = 176/274 (64%), Gaps = 7/274 (2%)
Query: 1 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE 60
M +L GY LG +GEGSY+KVK A S++ K VAIK++DR++AP DF+ KFLPRE
Sbjct: 1 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE 60
Query: 61 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL 120
+ IL + H I+ +E E +GK+YIVME A DLL+ ++ G + +AR F Q+
Sbjct: 61 LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQI 119
Query: 121 SLAIKYCHDLDVVHRDLKCDNLLLDKD-FNIKLSDFSFSKRCLRDDSGRMALSKTFCGSP 179
+ A++Y HD +VHRDLKC+N+LL D +KL+DF F R G LS T+CGS
Sbjct: 120 AGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG----RQAHGYPDLSTTYCGSA 175
Query: 180 AYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSK 239
AYA+PEVL GIPY PK YD+WS+GV+LY+MV G MP+DDS+I + R QK V +P
Sbjct: 176 AYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQK-RGVLYPEGL 234
Query: 240 HLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQ 273
L+ CK LI +LQ + R ++ +CW++
Sbjct: 235 ELSERCKALIAELLQFSPSARPSAGQVARNCWLR 268
>gi|42734401 testis-specific serine kinase 4 [Homo sapiens]
Length = 328
Score = 224 bits (570), Expect = 1e-58
Identities = 122/279 (43%), Positives = 175/279 (62%), Gaps = 14/279 (5%)
Query: 5 AVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEIL 64
+++ GY +G +G GSY V A+ + K VA+KII +KKA D+L KFLPREI+++
Sbjct: 18 SLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVM 77
Query: 65 AMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAI 124
+L H +I Y E++ +VYI++ELA GD+LE I+ GA E A K F QL+L I
Sbjct: 78 KVLRHKYLINFYRAIEST-SRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGI 136
Query: 125 KYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKR-----------CLRDDSGRMALSK 173
Y H +VHRDLK +NLLLDK N+K+SDF F+K R + LS+
Sbjct: 137 AYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQ 196
Query: 174 TFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRV 233
T+CGS AYA PE+L+G+PY P + D WS+GVILY +V +P+DD+N+KK+LR + + V
Sbjct: 197 TYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLR-ETQKEV 255
Query: 234 NFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWM 272
FP + ++ ECK+LI ML+ +R I +I+ W+
Sbjct: 256 TFPANHTISQECKNLILQMLR-QATKRATILDIIKDSWV 293
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 205 bits (521), Expect = 6e-53
Identities = 112/256 (43%), Positives = 159/256 (62%), Gaps = 9/256 (3%)
Query: 18 LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYE 77
LG+G++A VK A K VAIKIID+ + + LEK RE++++ +LNH IIK Y+
Sbjct: 33 LGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPHIIKLYQ 91
Query: 78 IFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDL 137
+ ET +YIV E A G++ + + + G L E+EARKKF Q+ A++YCHD +VHRDL
Sbjct: 92 VMETKD-MLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDL 150
Query: 138 KCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVY 197
K +NLLLD + +IKL+DF F + T+CGSP YAAPEV +G Y+
Sbjct: 151 KTENLLLDGNMDIKLADFGFGNFYKSGEP-----LSTWCGSPPYAAPEVFEGKEYEGPQL 205
Query: 198 DIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDV 257
DIWSLGV+LY++VCGS+P+D N+ + + E R P ++ +C+ LI ML D
Sbjct: 206 DIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIP--FFMSQDCESLIRRMLVVDP 263
Query: 258 NRRLHIDEILSHCWMQ 273
RR+ I +I H WM+
Sbjct: 264 ARRITIAQIRQHRWMR 279
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 199 bits (506), Expect = 3e-51
Identities = 108/264 (40%), Positives = 163/264 (61%), Gaps = 13/264 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y + +G+G++A VK A K VAIKIID+ + + L+K RE++I+ ML H
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPH 66
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
II+ Y++ ET +Y+V E A G++ + + G + E EAR+KF Q+ A+ +CH +
Sbjct: 67 IIRLYQVMETER-MIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 125
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD + NIK++DF FS L KT+CGSP YAAPE+ +G
Sbjct: 126 IVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ-----LLKTWCGSPPYAAPELFEGKE 180
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y DIWSLGV+LY++VCG++P+D S ++ + + + R+ F ++ EC+ LI
Sbjct: 181 YDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF----FMSTECEHLI 236
Query: 250 YHMLQPDVNRRLHIDEILSHCWMQ 273
HML D N+RL +++I H WM+
Sbjct: 237 RHMLVLDPNKRLSMEQICKHKWMK 260
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 197 bits (502), Expect = 1e-50
Identities = 108/255 (42%), Positives = 155/255 (60%), Gaps = 9/255 (3%)
Query: 18 LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYE 77
LG+G++A VK K VAIKIID+ + A LEK RE++I+ ML+H IIK Y+
Sbjct: 26 LGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIY-REVQIMKMLDHPHIIKLYQ 84
Query: 78 IFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDL 137
+ ET +Y+V E A G++ + + G L+E EAR+KF Q+ A+ YCH +VHRDL
Sbjct: 85 VMETK-SMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDL 143
Query: 138 KCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVY 197
K +NLLLD + NIK++DF F + L T+CGSP YAAPEV +G Y+
Sbjct: 144 KAENLLLDNNMNIKIADFGFGNFFKSGE-----LLATWCGSPPYAAPEVFEGQQYEGPQL 198
Query: 198 DIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDV 257
DIWS+GV+LY++VCG++P+D + + + E R P ++ +C+ LI ML D
Sbjct: 199 DIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIP--YFMSEDCEHLIRRMLVLDP 256
Query: 258 NRRLHIDEILSHCWM 272
++RL I +I H WM
Sbjct: 257 SKRLTIAQIKEHKWM 271
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 191 bits (485), Expect = 9e-49
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VA+KIID+ + + L+K RE+ I+ +LNH +
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y+VME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 112 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS + TFCGSP YAAPE+ QG
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 225
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 226 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 281
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + ++R +++I+ WM
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 191 bits (485), Expect = 9e-49
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VA+KIID+ + + L+K RE+ I+ +LNH +
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y+VME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 112 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS + TFCGSP YAAPE+ QG
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 225
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 226 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 281
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + ++R +++I+ WM
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 191 bits (485), Expect = 9e-49
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VA+KIID+ + + L+K RE+ I+ +LNH +
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y+VME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 112 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS + TFCGSP YAAPE+ QG
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 225
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 226 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 281
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + ++R +++I+ WM
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 191 bits (485), Expect = 9e-49
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VA+KIID+ + + L+K RE+ I+ +LNH +
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y+VME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 112 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS + TFCGSP YAAPE+ QG
Sbjct: 171 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 225
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 226 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 281
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + ++R +++I+ WM
Sbjct: 282 KKFLILNPSKRGTLEQIMKDRWM 304
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 191 bits (485), Expect = 9e-49
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VA+KIID+ + + L+K RE+ I+ +LNH +
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 78
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y+VME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 79 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 137
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS + TFCGSP YAAPE+ QG
Sbjct: 138 IVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNK-----LDTFCGSPPYAAPELFQGKK 192
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 193 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 248
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + ++R +++I+ WM
Sbjct: 249 KKFLILNPSKRGTLEQIMKDRWM 271
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 191 bits (484), Expect = 1e-48
Identities = 104/263 (39%), Positives = 161/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VA+KIID+ + L+K RE+ I+ +LNH +
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 118
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y+VME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 119 IVKLFEVIETEK-TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY 177
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS + TFCGSP YAAPE+ QG
Sbjct: 178 IVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNK-----LDTFCGSPPYAAPELFQGKK 232
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 233 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 288
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
+L + +R +++I+ WM
Sbjct: 289 KKLLVLNPIKRGSLEQIMKDRWM 311
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 189 bits (479), Expect = 4e-48
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VAIKIID+ + L+K RE+ I+ +LNH +
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y++ME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 115 IVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS G++ TFCGSP YAAPE+ QG
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKK 228
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 229 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 284
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + +R +++I+ W+
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 189 bits (479), Expect = 4e-48
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VAIKIID+ + L+K RE+ I+ +LNH +
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y++ME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 115 IVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS G++ TFCGSP YAAPE+ QG
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKK 228
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 229 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 284
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + +R +++I+ W+
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 189 bits (479), Expect = 4e-48
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VAIKIID+ + L+K RE+ I+ +LNH +
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y++ME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 115 IVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS G++ TFCGSP YAAPE+ QG
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKK 228
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 229 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 284
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + +R +++I+ W+
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWI 307
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 189 bits (479), Expect = 4e-48
Identities = 104/263 (39%), Positives = 162/263 (61%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VAIKIID+ + L+K RE+ I+ +LNH +
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y++ME A G++ + + G + E EAR KF Q+ A++YCH
Sbjct: 115 IVKLFEVIETEK-TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD D NIK++DF FS G++ TFCGSP YAAPE+ QG
Sbjct: 174 IVHRDLKAENLLLDADMNIKIADFGFSNEF--TVGGKL---DTFCGSPPYAAPELFQGKK 228
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y D+WSLGVILY +V GS+P+D N+K++ ++ ++R+ F +++ +C++L+
Sbjct: 229 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF----YMSTDCENLL 284
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + +R +++I+ W+
Sbjct: 285 KRFLVLNPIKRGTLEQIMKDRWI 307
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 187 bits (474), Expect = 2e-47
Identities = 104/263 (39%), Positives = 158/263 (60%), Gaps = 13/263 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L +G+G++AKVK A VAIKIID+ + L+K RE+ I+ LNH +
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVRIMKGLNHPN 117
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
I+K +E+ ET +Y+VME A G++ + + + G + E EAR KF Q+ A+ YCH +
Sbjct: 118 IVKLFEVIETEK-TLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN 176
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+VHRDLK +NLLLD + NIK++DF FS TFCGSP YAAPE+ QG
Sbjct: 177 IVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSK-----LDTFCGSPPYAAPELFQGKK 231
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLI 249
Y DIWSLGVILY +V GS+P+D N+K++ ++ ++RV F +++ +C+ ++
Sbjct: 232 YDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPF----YMSTDCESIL 287
Query: 250 YHMLQPDVNRRLHIDEILSHCWM 272
L + +R +++I+ W+
Sbjct: 288 RRFLVLNPAKRCTLEQIMKDKWI 310
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 179 bits (453), Expect = 5e-45
Identities = 108/266 (40%), Positives = 150/266 (56%), Gaps = 10/266 (3%)
Query: 7 LKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAM 66
LK R Y L LG+G+Y KVK A VAIK I + K + + REIEI++
Sbjct: 51 LKHR-YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSS 109
Query: 67 LNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKY 126
LNH II YE+FE K+ I+ME A +G+L + I R L E E R F Q+ A+ Y
Sbjct: 110 LNHPHIISIYEVFENKD-KIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHY 168
Query: 127 CHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEV 186
CH VVHRDLK +N+LLD + NIK++DF S +D +TFCGSP YA+PE+
Sbjct: 169 CHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKD-----KFLQTFCGSPLYASPEI 223
Query: 187 LQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECK 246
+ G PY+ D W+LGV+LY +V G+MP+D + K ++R P + +
Sbjct: 224 VNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQ---PSDAR 280
Query: 247 DLIYHMLQPDVNRRLHIDEILSHCWM 272
LI ML + +RR I++I +H W+
Sbjct: 281 GLIRWMLMVNPDRRATIEDIANHWWV 306
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 174 bits (442), Expect = 9e-44
Identities = 105/264 (39%), Positives = 154/264 (58%), Gaps = 11/264 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L LG G +A VK A VA+K+ID+ K L +E+ + ++ H +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-LATGHLFQEVRCMKLVQHPN 74
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELI-KTRGALHEDEARKKFHQLSLAIKYCHDL 130
I++ YE+ +T K+Y+++EL GD+ + I K L+ED A+K F Q+ AI YCH L
Sbjct: 75 IVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 131 DVVHRDLKCDNLLL-DKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQG 189
VVHRDLK +N++ +K +KL+DF FS + G+ T CGS AY+APE+L G
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKLT--TSCGSLAYSAPEILLG 188
Query: 190 IPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLI 249
Y DIWSLGVIL+++VCG P+ ++N + L + + + P H++ ECKDLI
Sbjct: 189 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP--SHVSKECKDLI 246
Query: 250 YHMLQPDVNRRLHIDEILSHCWMQ 273
MLQ D RR ++EI +H W+Q
Sbjct: 247 TRMLQRDPKRRASLEEIENHPWLQ 270
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 174 bits (442), Expect = 9e-44
Identities = 105/264 (39%), Positives = 154/264 (58%), Gaps = 11/264 (4%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L LG G +A VK A VA+K+ID+ K L +E+ + ++ H +
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-LATGHLFQEVRCMKLVQHPN 74
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELI-KTRGALHEDEARKKFHQLSLAIKYCHDL 130
I++ YE+ +T K+Y+++EL GD+ + I K L+ED A+K F Q+ AI YCH L
Sbjct: 75 IVRLYEVIDTQT-KLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 131 DVVHRDLKCDNLLL-DKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQG 189
VVHRDLK +N++ +K +KL+DF FS + G+ T CGS AY+APE+L G
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKF---QPGKKLT--TSCGSLAYSAPEILLG 188
Query: 190 IPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLI 249
Y DIWSLGVIL+++VCG P+ ++N + L + + + P H++ ECKDLI
Sbjct: 189 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVP--SHVSKECKDLI 246
Query: 250 YHMLQPDVNRRLHIDEILSHCWMQ 273
MLQ D RR ++EI +H W+Q
Sbjct: 247 TRMLQRDPKRRASLEEIENHPWLQ 270
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 172 bits (435), Expect = 6e-43
Identities = 106/255 (41%), Positives = 147/255 (57%), Gaps = 10/255 (3%)
Query: 18 LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYE 77
LG+G+Y KVK A + VAIK I + K + + REIEI++ LNH II +E
Sbjct: 59 LGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHE 117
Query: 78 IFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDL 137
+FE S K+ IVME A +GDL + I R L E EAR F Q+ A+ YCH VVHRDL
Sbjct: 118 VFENS-SKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDL 176
Query: 138 KCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVY 197
K +N+LLD + NIK++DF S G+ +TFCGSP YA+PE++ G PY
Sbjct: 177 KLENILLDANGNIKIADFGLSNLY---HQGKFL--QTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 198 DIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDV 257
D WSLGV+LYI+V G+MP+D + K ++ K+ R + LI +L +
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILV---KQISNGAYREPPKPSDACGLIRWLLMVNP 288
Query: 258 NRRLHIDEILSHCWM 272
RR ++++ SH W+
Sbjct: 289 TRRATLEDVASHWWV 303
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 169 bits (428), Expect = 4e-42
Identities = 100/262 (38%), Positives = 145/262 (55%), Gaps = 8/262 (3%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y+LG LG G++ KVK E VA+KI++R+K + + + REI+ L + H
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
IIK Y++ T +++VME G+L + I G L E E+R+ F Q+ + YCH
Sbjct: 87 IIKLYQVISTP-SDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 145
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
VVHRDLK +N+LLD N K++DF S + D +T CGSP YAAPEV+ G
Sbjct: 146 VVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDG---EFLRTSCGSPNYAAPEVISGRL 200
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYH 251
Y DIWS GVILY ++CG++P+DD ++ + + K F ++L L+ H
Sbjct: 201 YAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFK--KICDGIFYTPQYLNPSVISLLKH 258
Query: 252 MLQPDVNRRLHIDEILSHCWMQ 273
MLQ D +R I +I H W +
Sbjct: 259 MLQVDPMKRATIKDIREHEWFK 280
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 168 bits (425), Expect = 8e-42
Identities = 100/262 (38%), Positives = 145/262 (55%), Gaps = 8/262 (3%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y+LG LG G++ KVK + VA+KI++R+K + + + REI+ L + H
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
IIK Y++ T ++VME G+L + I G + E EAR+ F Q+ A+ YCH
Sbjct: 76 IIKLYQVISTPTD-FFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
VVHRDLK +N+LLD N K++DF S + D +T CGSP YAAPEV+ G
Sbjct: 135 VVHRDLKPENVLLDAHMNAKIADFGLSN--MMSDG---EFLRTSCGSPNYAAPEVISGRL 189
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYH 251
Y DIWS GVILY ++CG++P+DD ++ + + K F ++L L+ H
Sbjct: 190 YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFK--KIRGGVFYIPEYLNRSVATLLMH 247
Query: 252 MLQPDVNRRLHIDEILSHCWMQ 273
MLQ D +R I +I H W +
Sbjct: 248 MLQVDPLKRATIKDIREHEWFK 269
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 167 bits (423), Expect = 1e-41
Identities = 94/260 (36%), Positives = 150/260 (57%), Gaps = 9/260 (3%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L LG+G VK VAIKI++R+K L K + REI IL ++ H
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPH 77
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
++K ++++E +Y+V+E G+L + + +G L EARK F Q+ A+ +CH
Sbjct: 78 VLKLHDVYENKK-YLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS 136
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+ HRDLK +NLLLD+ NI+++DF + + D +L +T CGSP YA PEV++G
Sbjct: 137 ICHRDLKPENLLLDEKNNIRIADFGMASLQVGD-----SLLETSCGSPHYACPEVIRGEK 191
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYH 251
Y + D+WS GVIL+ ++ G++P+DD N++++L +K R F + +C+ L+
Sbjct: 192 YDGRKADVWSCGVILFALLVGALPFDDDNLRQLL--EKVKRGVFHMPHFIPPDCQSLLRG 249
Query: 252 MLQPDVNRRLHIDEILSHCW 271
M++ D RRL ++ I H W
Sbjct: 250 MIEVDAARRLTLEHIQKHIW 269
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 165 bits (417), Expect = 7e-41
Identities = 92/260 (35%), Positives = 151/260 (58%), Gaps = 9/260 (3%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y L LG+G VK VAIKI++R+K L K + REI IL ++ H
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPH 92
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLD 131
++K ++++E +Y+V+E G+L + + +G L EARK F Q+ A+ +CH
Sbjct: 93 VLKLHDVYENKK-YLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYS 151
Query: 132 VVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIP 191
+ HRDLK +NLLLD+ NI+++DF + + D +L +T CGSP YA PEV++G
Sbjct: 152 ICHRDLKPENLLLDEKNNIRIADFGMASLQVGD-----SLLETSCGSPHYACPEVIKGEK 206
Query: 192 YQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYH 251
Y + D+WS GVIL+ ++ G++P+DD N++++L +K R F + +C+ L+
Sbjct: 207 YDGRRADMWSCGVILFALLVGALPFDDDNLRQLL--EKVKRGVFHMPHFIPPDCQSLLRG 264
Query: 252 MLQPDVNRRLHIDEILSHCW 271
M++ + +RL +++I H W
Sbjct: 265 MIEVEPEKRLSLEQIQKHPW 284
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 164 bits (416), Expect = 9e-41
Identities = 108/279 (38%), Positives = 162/279 (58%), Gaps = 16/279 (5%)
Query: 8 KRRG-YLLGIN-LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPAD-FLEKFLPREIEIL 64
KR G YL+G LGEGS+AKV+ VAIK+ID+K+A D ++ K L RE +I
Sbjct: 56 KRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQ 115
Query: 65 AMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAI 124
M+ H +I + +I ET + Y+VMEL G+L+ I + L E EAR+ QL A+
Sbjct: 116 QMIRHPNITQLLDILETENS-YYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAV 174
Query: 125 KYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTF---CGSPAY 181
++ H VVHRDLK +NLLLD+D NIKL DF S + +G + S F CGSPAY
Sbjct: 175 EHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLS-----NCAGILGYSDPFSTQCGSPAY 229
Query: 182 AAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPY--DDSNIKKMLRIQKEHRVNFPRSK 239
AAPE+L Y PK+ D+WS+GV +Y M+ G++P+ + +++ + + + +N P
Sbjct: 230 AAPELLARKKYGPKI-DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMN-PLPT 287
Query: 240 HLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARG 278
L+ + +L+PD +R +I + L++ W+ G
Sbjct: 288 QLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTG 326
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 159 bits (402), Expect = 4e-39
Identities = 99/277 (35%), Positives = 144/277 (51%), Gaps = 23/277 (8%)
Query: 12 YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCS 71
Y+LG LG G++ KVK E VA+KI++R+K + + + REI+ L + H
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
Query: 72 IIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGA---------------LHEDEARKK 116
IIK Y++ T +++VME G+L + I G L E E+R+
Sbjct: 87 IIKLYQVISTP-SDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRL 145
Query: 117 FHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFC 176
F Q+ + YCH VVHRDLK +N+LLD N K++DF S + +T C
Sbjct: 146 FQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE-----FLRTSC 200
Query: 177 GSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFP 236
GSP YAAPEV+ G Y DIWS GVILY ++CG++P+DD ++ + + K F
Sbjct: 201 GSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFK--KICDGIFY 258
Query: 237 RSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQ 273
++L L+ HMLQ D +R I +I H W +
Sbjct: 259 TPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFK 295
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 159 bits (402), Expect = 4e-39
Identities = 99/267 (37%), Positives = 148/267 (55%), Gaps = 10/267 (3%)
Query: 8 KRRG-YLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAM 66
KR G Y + +G G++++VK K VAIKI+D+ K ++ L REI +
Sbjct: 69 KRIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQK-TQRLLSREISSMEK 127
Query: 67 LNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKY 126
L+H +II+ YE+ ET K+++VME A G+L I T G L E E++ F Q+ A+K+
Sbjct: 128 LHHPNIIRLYEVVETL-SKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKH 186
Query: 127 CHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEV 186
H+ ++HRDLK +N+ + +K+ DF FS S + + TFCGSP YAAPE+
Sbjct: 187 MHENQIIHRDLKAENVFYTSNTCVKVGDFGFS-----TVSKKGEMLNTFCGSPPYAAPEL 241
Query: 187 LQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECK 246
+ Y DIW+LGV+LY MV G+MP+ + K+ + E + P H++ C
Sbjct: 242 FRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVP--PHVSEPCH 299
Query: 247 DLIYHMLQPDVNRRLHIDEILSHCWMQ 273
LI +LQ R ID I++ WMQ
Sbjct: 300 RLIRGVLQQIPTERYGIDCIMNDEWMQ 326
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,421,069
Number of Sequences: 37866
Number of extensions: 766856
Number of successful extensions: 6166
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 687
Number of HSP's successfully gapped in prelim test: 233
Number of HSP's that attempted gapping in prelim test: 3604
Number of HSP's gapped (non-prelim): 1311
length of query: 367
length of database: 18,247,518
effective HSP length: 104
effective length of query: 263
effective length of database: 14,309,454
effective search space: 3763386402
effective search space used: 3763386402
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.