Search of human proteins with 7669550

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7669550 vinculin isoform meta-VCL [Homo sapiens]
         (1134 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7669550 vinculin isoform meta-VCL [Homo sapiens]                  2197   0.0  
gi|4507877 vinculin isoform VCL [Homo sapiens]                       1947   0.0  
gi|55770846 catenin, alpha 2 [Homo sapiens]                           135   2e-31
gi|55770844 catenin, alpha 1 [Homo sapiens]                           114   7e-25
gi|188497718 catenin, alpha 3 [Homo sapiens]                          107   5e-23
gi|188497716 catenin, alpha 3 [Homo sapiens]                          107   5e-23
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    54   6e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    54   6e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    54   6e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    54   6e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        54   6e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        54   6e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         54   6e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         54   6e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         54   6e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         54   6e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         54   6e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         54   6e-07
gi|112420968 coiled-coil domain containing 158 [Homo sapiens]          52   4e-06
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    50   9e-06
gi|156938343 talin 2 [Homo sapiens]                                    50   2e-05
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    48   5e-05
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    48   5e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    48   6e-05
gi|33356148 formin-like 1 [Homo sapiens]                               48   6e-05
gi|126723390 ankyrin repeat domain 24 [Homo sapiens]                   48   6e-05
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     47   8e-05
gi|33188443 microfilament and actin filament cross-linker protei...    47   1e-04
gi|33188445 microfilament and actin filament cross-linker protei...    47   1e-04
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    46   2e-04

>gi|7669550 vinculin isoform meta-VCL [Homo sapiens]
          Length = 1134

 Score = 2197 bits (5693), Expect = 0.0
 Identities = 1134/1134 (100%), Positives = 1134/1134 (100%)

Query: 1    MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE 60
            MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE
Sbjct: 1    MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE 60

Query: 61   TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120
            TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS
Sbjct: 61   TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120

Query: 121  DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ 180
            DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ
Sbjct: 121  DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ 180

Query: 181  ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE 240
            ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE
Sbjct: 181  ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE 240

Query: 241  INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR 300
            INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR
Sbjct: 241  INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR 300

Query: 301  QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL 360
            QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL
Sbjct: 301  QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL 360

Query: 361  DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE 420
            DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE
Sbjct: 361  DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE 420

Query: 421  LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA 480
            LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA
Sbjct: 421  LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA 480

Query: 481  VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD 540
            VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD
Sbjct: 481  VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD 540

Query: 541  LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS 600
            LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS
Sbjct: 541  LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS 600

Query: 601  DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG 660
            DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG
Sbjct: 601  DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG 660

Query: 661  IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK 720
            IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK
Sbjct: 661  IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK 720

Query: 721  SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR 780
            SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR
Sbjct: 721  SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR 780

Query: 781  EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840
            EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP
Sbjct: 781  EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840

Query: 841  DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM 900
            DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM
Sbjct: 841  DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM 900

Query: 901  AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ 960
            AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ
Sbjct: 901  AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ 960

Query: 961  PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK 1020
            PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK
Sbjct: 961  PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK 1020

Query: 1021 DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS 1080
            DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS
Sbjct: 1021 DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS 1080

Query: 1081 DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 1134
            DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
Sbjct: 1081 DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 1134


>gi|4507877 vinculin isoform VCL [Homo sapiens]
          Length = 1066

 Score = 1947 bits (5043), Expect = 0.0
 Identities = 1032/1134 (91%), Positives = 1039/1134 (91%), Gaps = 68/1134 (5%)

Query: 1    MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE 60
            MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE
Sbjct: 1    MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKE 60

Query: 61   TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120
            TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS
Sbjct: 61   TVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120

Query: 121  DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ 180
            DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ
Sbjct: 121  DLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQ 180

Query: 181  ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE 240
            ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE
Sbjct: 181  ELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE 240

Query: 241  INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR 300
            INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR
Sbjct: 241  INEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIR 300

Query: 301  QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL 360
            QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL
Sbjct: 301  QILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGL 360

Query: 361  DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE 420
            DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE
Sbjct: 361  DVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAE 420

Query: 421  LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA 480
            LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA
Sbjct: 421  LCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRA 480

Query: 481  VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD 540
            VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD
Sbjct: 481  VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD 540

Query: 541  LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS 600
            LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS
Sbjct: 541  LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFS 600

Query: 601  DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG 660
            DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG
Sbjct: 601  DTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEG 660

Query: 661  IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK 720
            IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK
Sbjct: 661  IQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTK 720

Query: 721  SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR 780
            SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR
Sbjct: 721  SLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFR 780

Query: 781  EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840
            EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP
Sbjct: 781  EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840

Query: 841  DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM 900
            DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM
Sbjct: 841  DFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM 900

Query: 901  AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQ 960
            AARQLHDEARKWSSK        G  ++A A                             
Sbjct: 901  AARQLHDEARKWSSK--------GNDIIAAAK---------------------------- 924

Query: 961  PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAK 1020
                 +L A  S  R     S     +I  AK +A    E++RL                
Sbjct: 925  --RMALLMAEMS--RLVRGGSGTKRALIQCAKDIAKASDEVTRL---------------- 964

Query: 1021 DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS 1080
                        AKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS
Sbjct: 965  ------------AKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNIS 1012

Query: 1081 DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 1134
            DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ
Sbjct: 1013 DEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ 1066


>gi|55770846 catenin, alpha 2 [Homo sapiens]
          Length = 905

 Score =  135 bits (341), Expect = 2e-31
 Identities = 176/763 (23%), Positives = 299/763 (39%), Gaps = 114/763 (14%)

Query: 404  GEEQIRGALAEARKIAELCDDPKERDDILRSLGEISA-----LTSKLADLRRQGKGDSPE 458
            G+E ++     AR+  EL  DP  RD++  + G +        T+  A LR      +  
Sbjct: 180  GKEMVKLNYVAARRQQEL-KDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRA 238

Query: 459  ARALA-KQVATALQNLQTKTNRAVANSRPAKAAVHLE-GKIEQAQRWIDNPTV-DDRGVG 515
             R    KQV  A+  +   +N A A S   +A  H   G++  A    DN  + D     
Sbjct: 239  NRDYVFKQVQEAIAGI---SNAAQATSPTDEAKGHTGIGELAAALNEFDNKIILDPMTFS 295

Query: 516  QAAIRGLVAEGHRLANVMMGPY------------RQDLLAKCDRVDQLTAQLADLAARGE 563
            +A  R  + E  RL +++ G              R+ ++A+C+ V Q    L        
Sbjct: 296  EARFRPSLEE--RLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNT 353

Query: 564  GESPQARAL---ASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAP 620
            G   +   L     ++    +DL+ ++++A+   +SD F +T  P+ +L  AA +     
Sbjct: 354  GRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSG---- 409

Query: 621  NREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAAR 680
            N +EV  E A  F  H+ KL   A  A ++   N+  V+ ++ +      L PQV++AA 
Sbjct: 410  NEKEV-KEYAQVFREHANKLVEVANLACSISN-NEEGVKLVRMAATQIDSLCPQVINAAL 467

Query: 681  ILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVA 740
             L   P ++ A ++ +  K+QW   V  +T  VD+       L  SE  I +D++KC +A
Sbjct: 468  TLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIA 527

Query: 741  MANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMD 800
            +       L   A +I  RA R++ +   E+EN E   + E V  A+  LS+T+ P   +
Sbjct: 528  LQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAE 587

Query: 801  -----AKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLT 855
                  +A++ N+  P  +  F+D+   +   V  +R+A              +  +R  
Sbjct: 588  QVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKA--------------VLMIRTP 633

Query: 856  DELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSSK 915
            +EL        E      R     E D+    Q A  ++ Q       ++ ++   +  +
Sbjct: 634  EELEDDSDFEQEDYDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQE 693

Query: 916  PGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHR 975
                 AEV                       DD   +++++       Q  +   +    
Sbjct: 694  KSKLDAEVA--------------------KWDDSGNDIIVL-----AKQMCMIMMEMTDF 728

Query: 976  EATKWSSKG-NDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAK 1034
               K   K  +D+I AAK++A   + M +L R                            
Sbjct: 729  TRGKGPLKNTSDVINAAKKIAEAGSRMDKLARA--------------------------- 761

Query: 1035 EVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHN 1094
             VA QC D   + +LL   +RI     QL I S VKA +             +   L+  
Sbjct: 762  -VADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQA 820

Query: 1095 AQNLMQSVKETVREAEAASIKIRTDAGF------TLRWVRKTP 1131
            A+NLM +V  TV+ +  AS K +   G        + W  K P
Sbjct: 821  AKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAP 863



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 87/377 (23%), Positives = 159/377 (42%), Gaps = 25/377 (6%)

Query: 6   TRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV--AAVQAAVSNLVRVGKETVQ 63
           T T+E +LEP+  Q++ LV    +G    K      A V  A+V+ A  N +  G++  +
Sbjct: 21  TLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIAK 80

Query: 64  TTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLL 123
            ++D  LK ++  A   V      +  A+     DP S   R  ++  +R +LS  + LL
Sbjct: 81  ESQD--LKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLL 138

Query: 124 LTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELT 183
           +  D A+V +++   K + E L   +     +DL    K  G  M K+  +   RQQEL 
Sbjct: 139 ILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELK 198

Query: 184 HQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINE 243
               R  +  +   +K+   +L +A + F+     ++  +     NR++  +++   I  
Sbjct: 199 DPHCRDEMAAARGALKKNATMLYTASQAFL-----RHPDVAATRANRDYVFKQVQEAIAG 253

Query: 244 IIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDP----SASPGDAGEQAI 299
           I    Q TS  ++A        +  AL   D+K+      + DP     A    + E+ +
Sbjct: 254 ISNAAQATSPTDEAKGHTGIGELAAALNEFDNKI------ILDPMTFSEARFRPSLEERL 307

Query: 300 RQILDEAGKVGE-LCAGKERRE-ILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVS 357
             I+  A  + +  C   +RRE I+  C  + Q    +        G      +K   ++
Sbjct: 308 ESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNTGRK----EKGDPLN 363

Query: 358 QGLDVLTAKVENAARKL 374
             +D +T K  +  R+L
Sbjct: 364 IAIDKMTKKTRDLRRQL 380


>gi|55770844 catenin, alpha 1 [Homo sapiens]
          Length = 906

 Score =  114 bits (284), Expect = 7e-25
 Identities = 85/305 (27%), Positives = 144/305 (47%), Gaps = 14/305 (4%)

Query: 538 RQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLK---DLKARMQEAMTQE 594
           R+ ++A+C+ V Q    L        G   ++ AL S +    K   DL+ ++++A+   
Sbjct: 330 RERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDH 389

Query: 595 VSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTAN 654
           VSD F +T  P+ +L  AA       N +EV  E A  F  H+ KL   A  A ++   N
Sbjct: 390 VSDSFLETNVPLLVLIEAAKNG----NEKEV-KEYAQVFREHANKLIEVANLACSISN-N 443

Query: 655 KSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVD 714
           +  V+ ++ S      L PQV++AA  L   P ++ A E+ +  K QW   V  +T  VD
Sbjct: 444 EEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVD 503

Query: 715 EAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENS 774
           +       L  SE  I +D++KC +A+       L   A +I  RA R++ V   E++N 
Sbjct: 504 DITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNY 563

Query: 775 EDPKFREAVKAASDELSKTISPMVMD-----AKAVAGNISDPGLQKSFLDSGYRILGAVA 829
           E   + E V  A+  LS T+ P   +      +A++ + + P  +  F+D+   +   + 
Sbjct: 564 EPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIR 623

Query: 830 KVREA 834
            +R+A
Sbjct: 624 DIRKA 628



 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 57/170 (33%), Positives = 83/170 (48%), Gaps = 14/170 (8%)

Query: 973  LHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRA--LIQCAKDIAKASDEVT 1030
            L  E +KW   GNDII  AK+M ++M EM+   RG    K    +I  AK IA+A   + 
Sbjct: 698  LDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMD 757

Query: 1031 RLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKA---TMLGRTNISDEESEQA 1087
            +L + +A  C D   + +LL   +RI     QL I S VKA    + G   +S  +S  +
Sbjct: 758  KLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMS 817

Query: 1088 TEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGF------TLRWVRKTP 1131
               L+  A+NLM +V +TV+ +  AS K +   G        + W  K P
Sbjct: 818  ---LIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAP 864



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 85/378 (22%), Positives = 166/378 (43%), Gaps = 26/378 (6%)

Query: 6   TRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV--AAVQAAVSNLVRVGKETVQ 63
           T  +E +LEP+  Q++ LV  + +G  + K      A V  A+V+ A  N +  G +  +
Sbjct: 22  TLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAK 81

Query: 64  TTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLL 123
             E Q LK ++  A   V      +  AA     DP S   R  ++  +R +LS  + LL
Sbjct: 82  --ESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLL 139

Query: 124 LTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELT 183
           +  D A+V K++   K + + +         +DL    K L P + K+  M  +RQQEL 
Sbjct: 140 ILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELK 199

Query: 184 HQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINE 243
              HR  +  +   +++ +P+L +A +  +     ++  +     NR+   +++   +  
Sbjct: 200 DVGHRDQMAAARGILQKNVPILYTASQACL-----QHPDVAAYKANRDLIYKQLQQAVTG 254

Query: 244 IIRVLQLTSWDE-DAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGD----AGEQA 298
           I    Q T+ D+           +  AL + D ++      + DP +   +    + E+ 
Sbjct: 255 ISNAAQATASDDASQHQGGGGGELAYALNNFDKQI------IVDPLSFSEERFRPSLEER 308

Query: 299 IRQILDEAGKVGE-LCAGKERRE-ILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQV 356
           +  I+  A  + +  C   +RRE I+  C  + Q    + DL +   G++    +++  +
Sbjct: 309 LESIISGAALMADSSCTRDDRRERIVAECNAVRQ---ALQDLLSEYMGNAG-RKERSDAL 364

Query: 357 SQGLDVLTAKVENAARKL 374
           +  +D +T K  +  R+L
Sbjct: 365 NSAIDKMTKKTRDLRRQL 382


>gi|188497718 catenin, alpha 3 [Homo sapiens]
          Length = 895

 Score =  107 bits (268), Expect = 5e-23
 Identities = 100/405 (24%), Positives = 176/405 (43%), Gaps = 32/405 (7%)

Query: 402 PEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARA 461
           P   ++I GA A            KE   +L S+       S +A L+        E + 
Sbjct: 198 PNQRDEIAGARASL----------KENSPLLHSICSACLEHSDVASLKASKDTVCEEIQN 247

Query: 462 LAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWID-NP-TVDDRGVGQAAI 519
               ++ A Q +Q  T      + P   A  L   +++ +  I  NP TV +  +  +  
Sbjct: 248 ALNVISNASQGIQNMT------TPPEPQAATLGSALDELENLIVLNPLTVTEEEIRPSLE 301

Query: 520 RGLVA--EGHRL---ANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALAS 574
           + L A   G  L   ++     +R+ ++A+C+ + Q    L        G+  ++  L  
Sbjct: 302 KRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNAGKKERSNTLNI 361

Query: 575 QLQDSLK---DLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAA 631
            L +  K   DL+ ++++A+   VSD F DTT P+ +L  AA        RE+   E AA
Sbjct: 362 ALDNMCKKTRDLRRQLRKAIIDHVSDSFLDTTVPLLVLIEAAKN-----GREKEIKEYAA 416

Query: 632 NFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAA 691
            F  H+ +L   A  A ++ T N+  ++ ++ +      L PQ+++AA  L   P +QA 
Sbjct: 417 IFHEHTSRLVEVANLACSMST-NEDGIKIVKIAANHLETLCPQIINAALALAARPKSQAV 475

Query: 692 YEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVA 751
               E  K  W +++  +T  VD+       L  SE  I +D++KC +A+ +     L  
Sbjct: 476 KNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILEDVNKCIIALRDQDADNLDR 535

Query: 752 GATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISP 796
            A +I  RA R+  +   E+++ E   + E V    + L+ T+ P
Sbjct: 536 AAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIP 580



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 51/146 (34%), Positives = 74/146 (50%), Gaps = 2/146 (1%)

Query: 973  LHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRA--LIQCAKDIAKASDEVT 1030
            L  E   W    NDII  AK M ++M EM+   RG    K    +I  AK I+++   + 
Sbjct: 687  LDAEIEIWDDTSNDIIVLAKNMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMD 746

Query: 1031 RLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEM 1090
             LA+++A QC D   + +LL   E+I   S QLKI S VKA +          +  +   
Sbjct: 747  VLARQIANQCPDPSCKQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIMSALDSVTS 806

Query: 1091 LVHNAQNLMQSVKETVREAEAASIKI 1116
            L+  A+NLM +V +TV+ +  AS KI
Sbjct: 807  LIQAAKNLMNAVVQTVKMSYIASTKI 832



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 48/203 (23%), Positives = 93/203 (45%), Gaps = 3/203 (1%)

Query: 6   TRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV-AAVQAAVSNLVRVGKETVQT 64
           T T+E +LEP+  Q++ LV   +      K      + + A+V+ A  NL+  G++  Q 
Sbjct: 20  TFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQ- 78

Query: 65  TEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLL 124
            E  +LK ++  +  +V      L  +A+    DP  +P R+ ++  +R +L+  + LL+
Sbjct: 79  -EATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLI 137

Query: 125 TFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTH 184
             D  +V  +++            + V    DL    + LG  +  +  +  +RQQ+L  
Sbjct: 138 LADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQDLKS 197

Query: 185 QEHRVMLVNSMNTVKELLPVLIS 207
              R  +  +  ++KE  P+L S
Sbjct: 198 PNQRDEIAGARASLKENSPLLHS 220


>gi|188497716 catenin, alpha 3 [Homo sapiens]
          Length = 895

 Score =  107 bits (268), Expect = 5e-23
 Identities = 100/405 (24%), Positives = 176/405 (43%), Gaps = 32/405 (7%)

Query: 402 PEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARA 461
           P   ++I GA A            KE   +L S+       S +A L+        E + 
Sbjct: 198 PNQRDEIAGARASL----------KENSPLLHSICSACLEHSDVASLKASKDTVCEEIQN 247

Query: 462 LAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWID-NP-TVDDRGVGQAAI 519
               ++ A Q +Q  T      + P   A  L   +++ +  I  NP TV +  +  +  
Sbjct: 248 ALNVISNASQGIQNMT------TPPEPQAATLGSALDELENLIVLNPLTVTEEEIRPSLE 301

Query: 520 RGLVA--EGHRL---ANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALAS 574
           + L A   G  L   ++     +R+ ++A+C+ + Q    L        G+  ++  L  
Sbjct: 302 KRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNAGKKERSNTLNI 361

Query: 575 QLQDSLK---DLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAA 631
            L +  K   DL+ ++++A+   VSD F DTT P+ +L  AA        RE+   E AA
Sbjct: 362 ALDNMCKKTRDLRRQLRKAIIDHVSDSFLDTTVPLLVLIEAAKN-----GREKEIKEYAA 416

Query: 632 NFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAA 691
            F  H+ +L   A  A ++ T N+  ++ ++ +      L PQ+++AA  L   P +QA 
Sbjct: 417 IFHEHTSRLVEVANLACSMST-NEDGIKIVKIAANHLETLCPQIINAALALAARPKSQAV 475

Query: 692 YEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVA 751
               E  K  W +++  +T  VD+       L  SE  I +D++KC +A+ +     L  
Sbjct: 476 KNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILEDVNKCIIALRDQDADNLDR 535

Query: 752 GATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISP 796
            A +I  RA R+  +   E+++ E   + E V    + L+ T+ P
Sbjct: 536 AAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIP 580



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 51/146 (34%), Positives = 74/146 (50%), Gaps = 2/146 (1%)

Query: 973  LHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRA--LIQCAKDIAKASDEVT 1030
            L  E   W    NDII  AK M ++M EM+   RG    K    +I  AK I+++   + 
Sbjct: 687  LDAEIEIWDDTSNDIIVLAKNMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMD 746

Query: 1031 RLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEM 1090
             LA+++A QC D   + +LL   E+I   S QLKI S VKA +          +  +   
Sbjct: 747  VLARQIANQCPDPSCKQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIMSALDSVTS 806

Query: 1091 LVHNAQNLMQSVKETVREAEAASIKI 1116
            L+  A+NLM +V +TV+ +  AS KI
Sbjct: 807  LIQAAKNLMNAVVQTVKMSYIASTKI 832



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 48/203 (23%), Positives = 93/203 (45%), Gaps = 3/203 (1%)

Query: 6   TRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPV-AAVQAAVSNLVRVGKETVQT 64
           T T+E +LEP+  Q++ LV   +      K      + + A+V+ A  NL+  G++  Q 
Sbjct: 20  TFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQ- 78

Query: 65  TEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLL 124
            E  +LK ++  +  +V      L  +A+    DP  +P R+ ++  +R +L+  + LL+
Sbjct: 79  -EATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLI 137

Query: 125 TFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTH 184
             D  +V  +++            + V    DL    + LG  +  +  +  +RQQ+L  
Sbjct: 138 LADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFKRQQDLKS 197

Query: 185 QEHRVMLVNSMNTVKELLPVLIS 207
              R  +  +  ++KE  P+L S
Sbjct: 198 PNQRDEIAGARASLKENSPLLHS 220


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 192/1035 (18%), Positives = 383/1035 (37%), Gaps = 154/1035 (14%)

Query: 142  LEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQEL-THQEHRVMLVNSMNTVKE 200
            LE +T    ++ +ED +    +    ++K  K+++ER  +L T+         ++  +K 
Sbjct: 971  LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030

Query: 201  LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260
                +IS +++ +  +    Q +E+ LK +   +E  +++ +E I  LQ    +     +
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEK-LKRK---LEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 261  KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERRE 320
            K  E ++ ALA +D ++ Q    L+      G   +  +++ LD + +     A K++R+
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISD--LQEDLD-SERAARNKAEKQKRD 1143

Query: 321  ILGTCKMLGQMTDQVAD-------LRARGQGSSPV---------------AMQKAQQVSQ 358
            +    + L    +   D       LRA+ +    V                 +  Q+ +Q
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203

Query: 359  GLDVLTAKVENAARKLEAMTNSKQSIAKK-IDAAQNWLADPNGGPEGEEQIRGALAEARK 417
             ++ LT ++E   R    +  +KQ++ K+  D A           E E + +   A+ ++
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263

Query: 418  IAELCDDPKE-----RDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQN 472
            +   C D +       D + +   E+ ++T  L +   +GK     A  LAK VA+    
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGK-----AIKLAKDVASLSSQ 1316

Query: 473  LQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANV 532
            LQ         +R     +++  K+ Q +   +  ++ D+   +   +  +       N+
Sbjct: 1317 LQDTQELLQEETR---QKLNVSTKLRQLEE--ERNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 533  MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMT 592
             +   ++ L      V+ L           E  + Q    A+   D L+  K R+Q    
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQ---- 1426

Query: 593  QEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT 652
            QE+ D+  D     +L++       +   ++  FD+  A  +N S K     ++A A   
Sbjct: 1427 QELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEA--- 1476

Query: 653  ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGL 712
                           ARE   + +S AR L        A E  E         +E +   
Sbjct: 1477 --------------EAREKETKALSLARAL---EEALEAKEELERTNKMLKAEMEDLVSS 1519

Query: 713  VDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILL------- 765
             D+       L+ S+ A++  +++ K  +  ++ ++       +    N   L       
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579

Query: 766  VAKREVENSEDPK-FREAVKAASDELSKTISPMVMDA---KAVAGNISDPGLQKSFLDSG 821
            +  R+ +N E  +  +  +     EL        + A   K + G++ D  LQ    DS 
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ---ADSA 1636

Query: 822  YRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEK 881
             +      K     Q Q  DF        Q  L D  A                     +
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDF--------QRELEDARA--------------------SR 1668

Query: 882  DEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPV 941
            DE F   K  E   + +     QL ++    +++     A++    +AE  A+  +G   
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNA 1726

Query: 942  PPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAA---------- 991
              D +   E  +  +       Q  + A     R+AT+ + + ++ +A            
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 992  --------KRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCT-- 1041
                    K +   + EM   V+  S  K  +      IA+  ++V + A+E  KQ    
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEARE--KQAATK 1842

Query: 1042 -----DKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQ 1096
                 DK+++  LLQV E    ++ Q K  +      + +     EE+E+ ++ +  N +
Sbjct: 1843 SLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901

Query: 1097 NLMQSVKETVREAEA 1111
             L + + E     EA
Sbjct: 1902 KLQRELDEATESNEA 1916



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 164/812 (20%), Positives = 326/812 (40%), Gaps = 105/812 (12%)

Query: 21   SHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILK--RDMPPAF 78
            SH   + E  +   +A+ +LT  +   + A +NL +  K+T++     +    R +  A 
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 1247

Query: 79   IKVENACTKLVQAAQMLQSD-PYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRV 137
             +VE+   KL    Q LQS       AR  L D    + +    +    +EAE  K I++
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE-GKAIKL 1306

Query: 138  CKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDER---QQELTHQ-EHRVMLVN 193
             K +    +  ++ +T E L   T+      TK+ ++ +ER   Q +L  + E +  L  
Sbjct: 1307 AKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364

Query: 194  SMNTVKELLPVLISAMKIFVTTKNSKNQG---IEEALKNRNFTVEKMSAEINEIIRVLQL 250
             ++T+   L      ++ F +T  +  +G    ++ ++N     E+ +A  +++ +    
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 251  TSWDEDAWASKDTEAMKRALASIDSK---LNQAKGWLRDPSASPGDAGEQAIRQILDEAG 307
               + D     D +  ++ +++++ K    +Q     ++ S+   D  ++A  +  ++  
Sbjct: 1425 LQQELDDLVV-DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483

Query: 308  KVGELCAGKE-----RREILGTCKML-GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLD 361
            K   L    E     + E+  T KML  +M D V+     G+    +   K    +Q ++
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-ME 1542

Query: 362  VLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAEL 421
             +  ++E    +L+A  ++K  +   + A +       G  E + Q R    E       
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALK-------GQFERDLQARDEQNE------- 1588

Query: 422  CDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
                ++R  + R L E     ++L D R+Q       A A  K++   L++L+ + + A+
Sbjct: 1589 ----EKRRQLQRQLHEYE---TELEDERKQ----RALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 482  ANSRPA-KAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQ- 539
                 A K    L+ +++  QR      ++D    +  I     E  + A  +     Q 
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692

Query: 540  -DLLAKCDRV--------DQLTAQLAD-LAARG--EGESPQARALASQLQDSLKDLKARM 587
             + LA  +R         ++L  +LA  L+ R   + E  +  A  +QL++ L++ +  M
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752

Query: 588  QEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647
             EAM+  V      T    +L    AT    A   E    +     +    KL    E  
Sbjct: 1753 -EAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH---EME 1805

Query: 648  AAVGTANKSTVEGIQASVKTARELTPQVVSAAR------------------ILLRNPGNQ 689
             AV +  KST+  ++A +    +L  QV   AR                  ILL+    +
Sbjct: 1806 GAVKSKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862

Query: 690  AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQML 749
               E ++    +    V+++   ++EA +    ++A+   ++++LD  +   +N      
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD--EATESNEAMGRE 1920

Query: 750  VAGATSIARRANRILLV------AKREVENSE 775
            V    S  RR N    V       +R +EN++
Sbjct: 1921 VNALKSKLRRGNETSFVPSRRSGGRRVIENAD 1952


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 192/1035 (18%), Positives = 383/1035 (37%), Gaps = 154/1035 (14%)

Query: 142  LEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQEL-THQEHRVMLVNSMNTVKE 200
            LE +T    ++ +ED +    +    ++K  K+++ER  +L T+         ++  +K 
Sbjct: 978  LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037

Query: 201  LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260
                +IS +++ +  +    Q +E+ LK +   +E  +++ +E I  LQ    +     +
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEK-LKRK---LEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 261  KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERRE 320
            K  E ++ ALA +D ++ Q    L+      G   +  +++ LD + +     A K++R+
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISD--LQEDLD-SERAARNKAEKQKRD 1150

Query: 321  ILGTCKMLGQMTDQVAD-------LRARGQGSSPV---------------AMQKAQQVSQ 358
            +    + L    +   D       LRA+ +    V                 +  Q+ +Q
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210

Query: 359  GLDVLTAKVENAARKLEAMTNSKQSIAKK-IDAAQNWLADPNGGPEGEEQIRGALAEARK 417
             ++ LT ++E   R    +  +KQ++ K+  D A           E E + +   A+ ++
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270

Query: 418  IAELCDDPKE-----RDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQN 472
            +   C D +       D + +   E+ ++T  L +   +GK     A  LAK VA+    
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGK-----AIKLAKDVASLSSQ 1323

Query: 473  LQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANV 532
            LQ         +R     +++  K+ Q +   +  ++ D+   +   +  +       N+
Sbjct: 1324 LQDTQELLQEETR---QKLNVSTKLRQLEE--ERNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 533  MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMT 592
             +   ++ L      V+ L           E  + Q    A+   D L+  K R+Q    
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQ---- 1433

Query: 593  QEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT 652
            QE+ D+  D     +L++       +   ++  FD+  A  +N S K     ++A A   
Sbjct: 1434 QELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEA--- 1483

Query: 653  ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGL 712
                           ARE   + +S AR L        A E  E         +E +   
Sbjct: 1484 --------------EAREKETKALSLARAL---EEALEAKEELERTNKMLKAEMEDLVSS 1526

Query: 713  VDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILL------- 765
             D+       L+ S+ A++  +++ K  +  ++ ++       +    N   L       
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586

Query: 766  VAKREVENSEDPK-FREAVKAASDELSKTISPMVMDA---KAVAGNISDPGLQKSFLDSG 821
            +  R+ +N E  +  +  +     EL        + A   K + G++ D  LQ    DS 
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ---ADSA 1643

Query: 822  YRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEK 881
             +      K     Q Q  DF        Q  L D  A                     +
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDF--------QRELEDARA--------------------SR 1675

Query: 882  DEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPV 941
            DE F   K  E   + +     QL ++    +++     A++    +AE  A+  +G   
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNA 1733

Query: 942  PPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAA---------- 991
              D +   E  +  +       Q  + A     R+AT+ + + ++ +A            
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 992  --------KRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCT-- 1041
                    K +   + EM   V+  S  K  +      IA+  ++V + A+E  KQ    
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEARE--KQAATK 1849

Query: 1042 -----DKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQ 1096
                 DK+++  LLQV E    ++ Q K  +      + +     EE+E+ ++ +  N +
Sbjct: 1850 SLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908

Query: 1097 NLMQSVKETVREAEA 1111
             L + + E     EA
Sbjct: 1909 KLQRELDEATESNEA 1923



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 164/812 (20%), Positives = 326/812 (40%), Gaps = 105/812 (12%)

Query: 21   SHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILK--RDMPPAF 78
            SH   + E  +   +A+ +LT  +   + A +NL +  K+T++     +    R +  A 
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 1254

Query: 79   IKVENACTKLVQAAQMLQSD-PYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRV 137
             +VE+   KL    Q LQS       AR  L D    + +    +    +EAE  K I++
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE-GKAIKL 1313

Query: 138  CKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDER---QQELTHQ-EHRVMLVN 193
             K +    +  ++ +T E L   T+      TK+ ++ +ER   Q +L  + E +  L  
Sbjct: 1314 AKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371

Query: 194  SMNTVKELLPVLISAMKIFVTTKNSKNQG---IEEALKNRNFTVEKMSAEINEIIRVLQL 250
             ++T+   L      ++ F +T  +  +G    ++ ++N     E+ +A  +++ +    
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 251  TSWDEDAWASKDTEAMKRALASIDSK---LNQAKGWLRDPSASPGDAGEQAIRQILDEAG 307
               + D     D +  ++ +++++ K    +Q     ++ S+   D  ++A  +  ++  
Sbjct: 1432 LQQELDDLVV-DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490

Query: 308  KVGELCAGKE-----RREILGTCKML-GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLD 361
            K   L    E     + E+  T KML  +M D V+     G+    +   K    +Q ++
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-ME 1549

Query: 362  VLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAEL 421
             +  ++E    +L+A  ++K  +   + A +       G  E + Q R    E       
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALK-------GQFERDLQARDEQNE------- 1595

Query: 422  CDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
                ++R  + R L E     ++L D R+Q       A A  K++   L++L+ + + A+
Sbjct: 1596 ----EKRRQLQRQLHEYE---TELEDERKQ----RALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 482  ANSRPA-KAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQ- 539
                 A K    L+ +++  QR      ++D    +  I     E  + A  +     Q 
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699

Query: 540  -DLLAKCDRV--------DQLTAQLAD-LAARG--EGESPQARALASQLQDSLKDLKARM 587
             + LA  +R         ++L  +LA  L+ R   + E  +  A  +QL++ L++ +  M
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759

Query: 588  QEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647
             EAM+  V      T    +L    AT    A   E    +     +    KL    E  
Sbjct: 1760 -EAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH---EME 1812

Query: 648  AAVGTANKSTVEGIQASVKTARELTPQVVSAAR------------------ILLRNPGNQ 689
             AV +  KST+  ++A +    +L  QV   AR                  ILL+    +
Sbjct: 1813 GAVKSKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869

Query: 690  AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQML 749
               E ++    +    V+++   ++EA +    ++A+   ++++LD  +   +N      
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD--EATESNEAMGRE 1927

Query: 750  VAGATSIARRANRILLV------AKREVENSE 775
            V    S  RR N    V       +R +EN++
Sbjct: 1928 VNALKSKLRRGNETSFVPSRRSGGRRVIENAD 1959


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 192/1035 (18%), Positives = 383/1035 (37%), Gaps = 154/1035 (14%)

Query: 142  LEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQEL-THQEHRVMLVNSMNTVKE 200
            LE +T    ++ +ED +    +    ++K  K+++ER  +L T+         ++  +K 
Sbjct: 978  LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037

Query: 201  LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260
                +IS +++ +  +    Q +E+ LK +   +E  +++ +E I  LQ    +     +
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEK-LKRK---LEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 261  KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERRE 320
            K  E ++ ALA +D ++ Q    L+      G   +  +++ LD + +     A K++R+
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISD--LQEDLD-SERAARNKAEKQKRD 1150

Query: 321  ILGTCKMLGQMTDQVAD-------LRARGQGSSPV---------------AMQKAQQVSQ 358
            +    + L    +   D       LRA+ +    V                 +  Q+ +Q
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210

Query: 359  GLDVLTAKVENAARKLEAMTNSKQSIAKK-IDAAQNWLADPNGGPEGEEQIRGALAEARK 417
             ++ LT ++E   R    +  +KQ++ K+  D A           E E + +   A+ ++
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270

Query: 418  IAELCDDPKE-----RDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQN 472
            +   C D +       D + +   E+ ++T  L +   +GK     A  LAK VA+    
Sbjct: 1271 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGK-----AIKLAKDVASLSSQ 1323

Query: 473  LQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANV 532
            LQ         +R     +++  K+ Q +   +  ++ D+   +   +  +       N+
Sbjct: 1324 LQDTQELLQEETR---QKLNVSTKLRQLEE--ERNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 533  MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMT 592
             +   ++ L      V+ L           E  + Q    A+   D L+  K R+Q    
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQ---- 1433

Query: 593  QEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT 652
            QE+ D+  D     +L++       +   ++  FD+  A  +N S K     ++A A   
Sbjct: 1434 QELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEA--- 1483

Query: 653  ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGL 712
                           ARE   + +S AR L        A E  E         +E +   
Sbjct: 1484 --------------EAREKETKALSLARAL---EEALEAKEELERTNKMLKAEMEDLVSS 1526

Query: 713  VDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILL------- 765
             D+       L+ S+ A++  +++ K  +  ++ ++       +    N   L       
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586

Query: 766  VAKREVENSEDPK-FREAVKAASDELSKTISPMVMDA---KAVAGNISDPGLQKSFLDSG 821
            +  R+ +N E  +  +  +     EL        + A   K + G++ D  LQ    DS 
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ---ADSA 1643

Query: 822  YRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEK 881
             +      K     Q Q  DF        Q  L D  A                     +
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDF--------QRELEDARA--------------------SR 1675

Query: 882  DEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPV 941
            DE F   K  E   + +     QL ++    +++     A++    +AE  A+  +G   
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNA 1733

Query: 942  PPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAA---------- 991
              D +   E  +  +       Q  + A     R+AT+ + + ++ +A            
Sbjct: 1734 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 992  --------KRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCT-- 1041
                    K +   + EM   V+  S  K  +      IA+  ++V + A+E  KQ    
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEARE--KQAATK 1849

Query: 1042 -----DKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQ 1096
                 DK+++  LLQV E    ++ Q K  +      + +     EE+E+ ++ +  N +
Sbjct: 1850 SLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908

Query: 1097 NLMQSVKETVREAEA 1111
             L + + E     EA
Sbjct: 1909 KLQRELDEATESNEA 1923



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 154/767 (20%), Positives = 311/767 (40%), Gaps = 97/767 (12%)

Query: 21   SHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILK--RDMPPAF 78
            SH   + E  +   +A+ +LT  +   + A +NL +  K+T++     +    R +  A 
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 1254

Query: 79   IKVENACTKLVQAAQMLQSD-PYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRV 137
             +VE+   KL    Q LQS       AR  L D    + +    +    +EAE  K I++
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE-GKAIKL 1313

Query: 138  CKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDER---QQELTHQ-EHRVMLVN 193
             K +    +  ++ +T E L   T+      TK+ ++ +ER   Q +L  + E +  L  
Sbjct: 1314 AKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371

Query: 194  SMNTVKELLPVLISAMKIFVTTKNSKNQG---IEEALKNRNFTVEKMSAEINEIIRVLQL 250
             ++T+   L      ++ F +T  +  +G    ++ ++N     E+ +A  +++ +    
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 251  TSWDEDAWASKDTEAMKRALASIDSK---LNQAKGWLRDPSASPGDAGEQAIRQILDEAG 307
               + D     D +  ++ +++++ K    +Q     ++ S+   D  ++A  +  ++  
Sbjct: 1432 LQQELDDLVV-DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490

Query: 308  KVGELCAGKE-----RREILGTCKML-GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLD 361
            K   L    E     + E+  T KML  +M D V+     G+    +   K    +Q ++
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-ME 1549

Query: 362  VLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAEL 421
             +  ++E    +L+A  ++K  +   + A +       G  E + Q R    E       
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALK-------GQFERDLQARDEQNE------- 1595

Query: 422  CDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
                ++R  + R L E     ++L D R+Q       A A  K++   L++L+ + + A+
Sbjct: 1596 ----EKRRQLQRQLHEYE---TELEDERKQ----RALAAAAKKKLEGDLKDLELQADSAI 1644

Query: 482  ANSRPA-KAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQ- 539
                 A K    L+ +++  QR      ++D    +  I     E  + A  +     Q 
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLMQL 1699

Query: 540  -DLLAKCDRV--------DQLTAQLAD-LAARG--EGESPQARALASQLQDSLKDLKARM 587
             + LA  +R         ++L  +LA  L+ R   + E  +  A  +QL++ L++ +  M
Sbjct: 1700 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1759

Query: 588  QEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647
             EAM+  V      T    +L    AT    A   E    +     +    KL    E  
Sbjct: 1760 -EAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH---EME 1812

Query: 648  AAVGTANKSTVEGIQASVKTARELTPQVVSAAR------------------ILLRNPGNQ 689
             AV +  KST+  ++A +    +L  QV   AR                  ILL+    +
Sbjct: 1813 GAVKSKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869

Query: 690  AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDK 736
               E ++    +    V+++   ++EA +    ++A+   ++++LD+
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 192/1035 (18%), Positives = 383/1035 (37%), Gaps = 154/1035 (14%)

Query: 142  LEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQEL-THQEHRVMLVNSMNTVKE 200
            LE +T    ++ +ED +    +    ++K  K+++ER  +L T+         ++  +K 
Sbjct: 971  LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030

Query: 201  LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260
                +IS +++ +  +    Q +E+ LK +   +E  +++ +E I  LQ    +     +
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEK-LKRK---LEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 261  KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERRE 320
            K  E ++ ALA +D ++ Q    L+      G   +  +++ LD + +     A K++R+
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISD--LQEDLD-SERAARNKAEKQKRD 1143

Query: 321  ILGTCKMLGQMTDQVAD-------LRARGQGSSPV---------------AMQKAQQVSQ 358
            +    + L    +   D       LRA+ +    V                 +  Q+ +Q
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203

Query: 359  GLDVLTAKVENAARKLEAMTNSKQSIAKK-IDAAQNWLADPNGGPEGEEQIRGALAEARK 417
             ++ LT ++E   R    +  +KQ++ K+  D A           E E + +   A+ ++
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263

Query: 418  IAELCDDPKE-----RDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQN 472
            +   C D +       D + +   E+ ++T  L +   +GK     A  LAK VA+    
Sbjct: 1264 LQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE--AEGK-----AIKLAKDVASLSSQ 1316

Query: 473  LQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANV 532
            LQ         +R     +++  K+ Q +   +  ++ D+   +   +  +       N+
Sbjct: 1317 LQDTQELLQEETR---QKLNVSTKLRQLEE--ERNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 533  MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMT 592
             +   ++ L      V+ L           E  + Q    A+   D L+  K R+Q    
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA-AYDKLEKTKNRLQ---- 1426

Query: 593  QEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT 652
            QE+ D+  D     +L++       +   ++  FD+  A  +N S K     ++A A   
Sbjct: 1427 QELDDLVVDLDNQRQLVS-------NLEKKQRKFDQLLAEEKNISSKYADERDRAEA--- 1476

Query: 653  ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGL 712
                           ARE   + +S AR L        A E  E         +E +   
Sbjct: 1477 --------------EAREKETKALSLARAL---EEALEAKEELERTNKMLKAEMEDLVSS 1519

Query: 713  VDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILL------- 765
             D+       L+ S+ A++  +++ K  +  ++ ++       +    N   L       
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579

Query: 766  VAKREVENSEDPK-FREAVKAASDELSKTISPMVMDA---KAVAGNISDPGLQKSFLDSG 821
            +  R+ +N E  +  +  +     EL        + A   K + G++ D  LQ    DS 
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQ---ADSA 1636

Query: 822  YRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEK 881
             +      K     Q Q  DF        Q  L D  A                     +
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDF--------QRELEDARA--------------------SR 1668

Query: 882  DEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPV 941
            DE F   K  E   + +     QL ++    +++     A++    +AE  A+  +G   
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNA 1726

Query: 942  PPDMEDDYEPELLLMPSNQPVNQPILAAAQSLHREATKWSSKGNDIIAAA---------- 991
              D +   E  +  +       Q  + A     R+AT+ + + ++ +A            
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 992  --------KRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCT-- 1041
                    K +   + EM   V+  S  K  +      IA+  ++V + A+E  KQ    
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVK--SKFKSTIAALEAKIAQLEEQVEQEARE--KQAATK 1842

Query: 1042 -----DKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQ 1096
                 DK+++  LLQV E    ++ Q K  +      + +     EE+E+ ++ +  N +
Sbjct: 1843 SLKQKDKKLKEILLQV-EDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901

Query: 1097 NLMQSVKETVREAEA 1111
             L + + E     EA
Sbjct: 1902 KLQRELDEATESNEA 1916



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 154/767 (20%), Positives = 311/767 (40%), Gaps = 97/767 (12%)

Query: 21   SHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILK--RDMPPAF 78
            SH   + E  +   +A+ +LT  +   + A +NL +  K+T++     +    R +  A 
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-NKQTLEKENADLAGELRVLGQAK 1247

Query: 79   IKVENACTKLVQAAQMLQSD-PYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRV 137
             +VE+   KL    Q LQS       AR  L D    + +    +    +EAE  K I++
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAE-GKAIKL 1306

Query: 138  CKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDER---QQELTHQ-EHRVMLVN 193
             K +    +  ++ +T E L   T+      TK+ ++ +ER   Q +L  + E +  L  
Sbjct: 1307 AKDVASLSS--QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364

Query: 194  SMNTVKELLPVLISAMKIFVTTKNSKNQG---IEEALKNRNFTVEKMSAEINEIIRVLQL 250
             ++T+   L      ++ F +T  +  +G    ++ ++N     E+ +A  +++ +    
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 251  TSWDEDAWASKDTEAMKRALASIDSK---LNQAKGWLRDPSASPGDAGEQAIRQILDEAG 307
               + D     D +  ++ +++++ K    +Q     ++ S+   D  ++A  +  ++  
Sbjct: 1425 LQQELDDLVV-DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483

Query: 308  KVGELCAGKE-----RREILGTCKML-GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLD 361
            K   L    E     + E+  T KML  +M D V+     G+    +   K    +Q ++
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ-ME 1542

Query: 362  VLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAEL 421
             +  ++E    +L+A  ++K  +   + A +       G  E + Q R    E       
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALK-------GQFERDLQARDEQNE------- 1588

Query: 422  CDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
                ++R  + R L E     ++L D R+Q       A A  K++   L++L+ + + A+
Sbjct: 1589 ----EKRRQLQRQLHEYE---TELEDERKQ----RALAAAAKKKLEGDLKDLELQADSAI 1637

Query: 482  ANSRPA-KAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQ- 539
                 A K    L+ +++  QR      ++D    +  I     E  + A  +     Q 
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQR-----ELEDARASRDEIFATAKENEKKAKSLEADLMQL 1692

Query: 540  -DLLAKCDRV--------DQLTAQLAD-LAARG--EGESPQARALASQLQDSLKDLKARM 587
             + LA  +R         ++L  +LA  L+ R   + E  +  A  +QL++ L++ +  M
Sbjct: 1693 QEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNM 1752

Query: 588  QEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647
             EAM+  V      T    +L    AT    A   E    +     +    KL    E  
Sbjct: 1753 -EAMSDRVRKA---TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH---EME 1805

Query: 648  AAVGTANKSTVEGIQASVKTARELTPQVVSAAR------------------ILLRNPGNQ 689
             AV +  KST+  ++A +    +L  QV   AR                  ILL+    +
Sbjct: 1806 GAVKSKFKSTIAALEAKIA---QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862

Query: 690  AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDK 736
               E ++    +    V+++   ++EA +    ++A+   ++++LD+
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)

Query: 224  EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
            EE ++     V+  +    I E ++ L+ +S  E    ++  EA +R+   I+ ++   +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458

Query: 282  GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
              L       G A GE QA+R   +EA    +  +  A + RR++    +   Q      
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1515

Query: 337  DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
            +L +R +  +  A +K Q+  Q L+ L  + E A R+L      +Q+  ++    Q  L 
Sbjct: 1516 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1568

Query: 397  DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
                  E E Q + A + A K A+L           RSL E     ++L +   +     
Sbjct: 1569 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1617

Query: 457  PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
             EA    ++    L+  Q K N A+     A+        A    E + E+A+R      
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677

Query: 505  --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
              +   V  R + +  +  +  +AEG     +        L A+ ++ +Q    L +  A
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
            R + E+  A     +L+  L  ++A M+     +A  +E S   S+ +           +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 608  LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
             LA  A        +A  + ++ +E AA     + ++   AEK AA+G A +   E    
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1855

Query: 662  ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
                +A  +  R L        R L        A   E    ++      +E+  GLV++
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915

Query: 716  AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
             +  +  ++    A+K   +K     A ++ ++  + + A    R   +  L A  +R++
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 772  ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
               E+ + REA +                 K++A        +K+ L+   R+   V + 
Sbjct: 1976 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2021

Query: 832  REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
            R   +  E +         QL+L  E A  +                EEK   F  Q+  
Sbjct: 2022 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2062

Query: 892  EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
            + + Q +        QL  EA   +++     AE    V AE +AA +            
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2111

Query: 949  YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
             E E L   + +         AAA+ L +EA + +++      AA R      AEM +  
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171

Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
            +    T R   Q  +++                  +E+ RL  E  +    +       Q
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2225

Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
            V E + ++  Q++ LS +KA +        + D+++ Q    L   A+ + Q  +E  R 
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2283

Query: 1109 AEAA 1112
            + AA
Sbjct: 2284 SVAA 2287



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)

Query: 330  QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
            ++ +  A L  + Q +   A  KAQ   +  ++     E   R+ EA  +++Q       
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1416

Query: 390  AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
            + Q  L       E E Q +   AEA + + L  + + R   L+          + GE+ 
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476

Query: 440  ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
            AL ++  +   Q +    EA  L +QV    Q            ++ +   A    R  +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536

Query: 489  AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
            A   L  + E+A+R +    V+     Q A+        R A   +   R     K  ++
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1592

Query: 549  DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
            ++         AQL + A R   +  +A     + +  L+  + +  EA+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)

Query: 224  EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
            EE ++     V+  +    I E ++ L+ +S  E    ++  EA +R+   I+ ++   +
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462

Query: 282  GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
              L       G A GE QA+R   +EA    +  +  A + RR++    +   Q      
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1519

Query: 337  DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
            +L +R +  +  A +K Q+  Q L+ L  + E A R+L      +Q+  ++    Q  L 
Sbjct: 1520 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1572

Query: 397  DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
                  E E Q + A + A K A+L           RSL E     ++L +   +     
Sbjct: 1573 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1621

Query: 457  PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
             EA    ++    L+  Q K N A+     A+        A    E + E+A+R      
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1681

Query: 505  --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
              +   V  R + +  +  +  +AEG     +        L A+ ++ +Q    L +  A
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
            R + E+  A     +L+  L  ++A M+     +A  +E S   S+ +           +
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1801

Query: 608  LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
             LA  A        +A  + ++ +E AA     + ++   AEK AA+G A +   E    
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1859

Query: 662  ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
                +A  +  R L        R L        A   E    ++      +E+  GLV++
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919

Query: 716  AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
             +  +  ++    A+K   +K     A ++ ++  + + A    R   +  L A  +R++
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979

Query: 772  ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
               E+ + REA +                 K++A        +K+ L+   R+   V + 
Sbjct: 1980 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2025

Query: 832  REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
            R   +  E +         QL+L  E A  +                EEK   F  Q+  
Sbjct: 2026 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2066

Query: 892  EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
            + + Q +        QL  EA   +++     AE    V AE +AA +            
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2115

Query: 949  YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
             E E L   + +         AAA+ L +EA + +++      AA R      AEM +  
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175

Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
            +    T R   Q  +++                  +E+ RL  E  +    +       Q
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2229

Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
            V E + ++  Q++ LS +KA +        + D+++ Q    L   A+ + Q  +E  R 
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2287

Query: 1109 AEAA 1112
            + AA
Sbjct: 2288 SVAA 2291



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)

Query: 330  QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
            ++ +  A L  + Q +   A  KAQ   +  ++     E   R+ EA  +++Q       
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1420

Query: 390  AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
            + Q  L       E E Q +   AEA + + L  + + R   L+          + GE+ 
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1480

Query: 440  ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
            AL ++  +   Q +    EA  L +QV    Q            ++ +   A    R  +
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540

Query: 489  AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
            A   L  + E+A+R +    V+     Q A+        R A   +   R     K  ++
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1596

Query: 549  DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
            ++         AQL + A R   +  +A     + +  L+  + +  EA+
Sbjct: 1597 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1646


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)

Query: 224  EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
            EE ++     V+  +    I E ++ L+ +S  E    ++  EA +R+   I+ ++   +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458

Query: 282  GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
              L       G A GE QA+R   +EA    +  +  A + RR++    +   Q      
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1515

Query: 337  DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
            +L +R +  +  A +K Q+  Q L+ L  + E A R+L      +Q+  ++    Q  L 
Sbjct: 1516 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1568

Query: 397  DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
                  E E Q + A + A K A+L           RSL E     ++L +   +     
Sbjct: 1569 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1617

Query: 457  PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
             EA    ++    L+  Q K N A+     A+        A    E + E+A+R      
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1677

Query: 505  --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
              +   V  R + +  +  +  +AEG     +        L A+ ++ +Q    L +  A
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
            R + E+  A     +L+  L  ++A M+     +A  +E S   S+ +           +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1797

Query: 608  LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
             LA  A        +A  + ++ +E AA     + ++   AEK AA+G A +   E    
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1855

Query: 662  ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
                +A  +  R L        R L        A   E    ++      +E+  GLV++
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915

Query: 716  AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
             +  +  ++    A+K   +K     A ++ ++  + + A    R   +  L A  +R++
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 772  ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
               E+ + REA +                 K++A        +K+ L+   R+   V + 
Sbjct: 1976 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2021

Query: 832  REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
            R   +  E +         QL+L  E A  +                EEK   F  Q+  
Sbjct: 2022 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2062

Query: 892  EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
            + + Q +        QL  EA   +++     AE    V AE +AA +            
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2111

Query: 949  YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
             E E L   + +         AAA+ L +EA + +++      AA R      AEM +  
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171

Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
            +    T R   Q  +++                  +E+ RL  E  +    +       Q
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2225

Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
            V E + ++  Q++ LS +KA +        + D+++ Q    L   A+ + Q  +E  R 
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2283

Query: 1109 AEAA 1112
            + AA
Sbjct: 2284 SVAA 2287



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)

Query: 330  QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
            ++ +  A L  + Q +   A  KAQ   +  ++     E   R+ EA  +++Q       
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1416

Query: 390  AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
            + Q  L       E E Q +   AEA + + L  + + R   L+          + GE+ 
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476

Query: 440  ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
            AL ++  +   Q +    EA  L +QV    Q            ++ +   A    R  +
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536

Query: 489  AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
            A   L  + E+A+R +    V+     Q A+        R A   +   R     K  ++
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1592

Query: 549  DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
            ++         AQL + A R   +  +A     + +  L+  + +  EA+
Sbjct: 1593 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1642


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)

Query: 224  EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
            EE ++     V+  +    I E ++ L+ +S  E    ++  EA +R+   I+ ++   +
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426

Query: 282  GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
              L       G A GE QA+R   +EA    +  +  A + RR++    +   Q      
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1483

Query: 337  DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
            +L +R +  +  A +K Q+  Q L+ L  + E A R+L      +Q+  ++    Q  L 
Sbjct: 1484 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1536

Query: 397  DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
                  E E Q + A + A K A+L           RSL E     ++L +   +     
Sbjct: 1537 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1585

Query: 457  PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
             EA    ++    L+  Q K N A+     A+        A    E + E+A+R      
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1645

Query: 505  --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
              +   V  R + +  +  +  +AEG     +        L A+ ++ +Q    L +  A
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
            R + E+  A     +L+  L  ++A M+     +A  +E S   S+ +           +
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1765

Query: 608  LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
             LA  A        +A  + ++ +E AA     + ++   AEK AA+G A +   E    
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1823

Query: 662  ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
                +A  +  R L        R L        A   E    ++      +E+  GLV++
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883

Query: 716  AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
             +  +  ++    A+K   +K     A ++ ++  + + A    R   +  L A  +R++
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943

Query: 772  ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
               E+ + REA +                 K++A        +K+ L+   R+   V + 
Sbjct: 1944 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 1989

Query: 832  REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
            R   +  E +         QL+L  E A  +                EEK   F  Q+  
Sbjct: 1990 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2030

Query: 892  EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
            + + Q +        QL  EA   +++     AE    V AE +AA +            
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2079

Query: 949  YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
             E E L   + +         AAA+ L +EA + +++      AA R      AEM +  
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139

Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
            +    T R   Q  +++                  +E+ RL  E  +    +       Q
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2193

Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
            V E + ++  Q++ LS +KA +        + D+++ Q    L   A+ + Q  +E  R 
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2251

Query: 1109 AEAA 1112
            + AA
Sbjct: 2252 SVAA 2255



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)

Query: 330  QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
            ++ +  A L  + Q +   A  KAQ   +  ++     E   R+ EA  +++Q       
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1384

Query: 390  AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
            + Q  L       E E Q +   AEA + + L  + + R   L+          + GE+ 
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1444

Query: 440  ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
            AL ++  +   Q +    EA  L +QV    Q            ++ +   A    R  +
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504

Query: 489  AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
            A   L  + E+A+R +    V+     Q A+        R A   +   R     K  ++
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1560

Query: 549  DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
            ++         AQL + A R   +  +A     + +  L+  + +  EA+
Sbjct: 1561 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1610


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)

Query: 224  EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
            EE ++     V+  +    I E ++ L+ +S  E    ++  EA +R+   I+ ++   +
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595

Query: 282  GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
              L       G A GE QA+R   +EA    +  +  A + RR++    +   Q      
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1652

Query: 337  DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
            +L +R +  +  A +K Q+  Q L+ L  + E A R+L      +Q+  ++    Q  L 
Sbjct: 1653 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1705

Query: 397  DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
                  E E Q + A + A K A+L           RSL E     ++L +   +     
Sbjct: 1706 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1754

Query: 457  PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
             EA    ++    L+  Q K N A+     A+        A    E + E+A+R      
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1814

Query: 505  --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
              +   V  R + +  +  +  +AEG     +        L A+ ++ +Q    L +  A
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
            R + E+  A     +L+  L  ++A M+     +A  +E S   S+ +           +
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1934

Query: 608  LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
             LA  A        +A  + ++ +E AA     + ++   AEK AA+G A +   E    
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1992

Query: 662  ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
                +A  +  R L        R L        A   E    ++      +E+  GLV++
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052

Query: 716  AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
             +  +  ++    A+K   +K     A ++ ++  + + A    R   +  L A  +R++
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112

Query: 772  ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
               E+ + REA +                 K++A        +K+ L+   R+   V + 
Sbjct: 2113 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2158

Query: 832  REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
            R   +  E +         QL+L  E A  +                EEK   F  Q+  
Sbjct: 2159 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2199

Query: 892  EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
            + + Q +        QL  EA   +++     AE    V AE +AA +            
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2248

Query: 949  YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
             E E L   + +         AAA+ L +EA + +++      AA R      AEM +  
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308

Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
            +    T R   Q  +++                  +E+ RL  E  +    +       Q
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2362

Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
            V E + ++  Q++ LS +KA +        + D+++ Q    L   A+ + Q  +E  R 
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2420

Query: 1109 AEAA 1112
            + AA
Sbjct: 2421 SVAA 2424



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)

Query: 330  QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
            ++ +  A L  + Q +   A  KAQ   +  ++     E   R+ EA  +++Q       
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1553

Query: 390  AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
            + Q  L       E E Q +   AEA + + L  + + R   L+          + GE+ 
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1613

Query: 440  ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
            AL ++  +   Q +    EA  L +QV    Q            ++ +   A    R  +
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673

Query: 489  AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
            A   L  + E+A+R +    V+     Q A+        R A   +   R     K  ++
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1729

Query: 549  DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
            ++         AQL + A R   +  +A     + +  L+  + +  EA+
Sbjct: 1730 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1779


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)

Query: 224  EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
            EE ++     V+  +    I E ++ L+ +S  E    ++  EA +R+   I+ ++   +
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436

Query: 282  GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
              L       G A GE QA+R   +EA    +  +  A + RR++    +   Q      
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1493

Query: 337  DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
            +L +R +  +  A +K Q+  Q L+ L  + E A R+L      +Q+  ++    Q  L 
Sbjct: 1494 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1546

Query: 397  DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
                  E E Q + A + A K A+L           RSL E     ++L +   +     
Sbjct: 1547 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1595

Query: 457  PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
             EA    ++    L+  Q K N A+     A+        A    E + E+A+R      
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1655

Query: 505  --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
              +   V  R + +  +  +  +AEG     +        L A+ ++ +Q    L +  A
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
            R + E+  A     +L+  L  ++A M+     +A  +E S   S+ +           +
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1775

Query: 608  LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
             LA  A        +A  + ++ +E AA     + ++   AEK AA+G A +   E    
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1833

Query: 662  ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
                +A  +  R L        R L        A   E    ++      +E+  GLV++
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893

Query: 716  AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
             +  +  ++    A+K   +K     A ++ ++  + + A    R   +  L A  +R++
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953

Query: 772  ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
               E+ + REA +                 K++A        +K+ L+   R+   V + 
Sbjct: 1954 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 1999

Query: 832  REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
            R   +  E +         QL+L  E A  +                EEK   F  Q+  
Sbjct: 2000 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2040

Query: 892  EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
            + + Q +        QL  EA   +++     AE    V AE +AA +            
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2089

Query: 949  YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
             E E L   + +         AAA+ L +EA + +++      AA R      AEM +  
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149

Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
            +    T R   Q  +++                  +E+ RL  E  +    +       Q
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2203

Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
            V E + ++  Q++ LS +KA +        + D+++ Q    L   A+ + Q  +E  R 
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2261

Query: 1109 AEAA 1112
            + AA
Sbjct: 2262 SVAA 2265



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)

Query: 330  QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
            ++ +  A L  + Q +   A  KAQ   +  ++     E   R+ EA  +++Q       
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1394

Query: 390  AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
            + Q  L       E E Q +   AEA + + L  + + R   L+          + GE+ 
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454

Query: 440  ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
            AL ++  +   Q +    EA  L +QV    Q            ++ +   A    R  +
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514

Query: 489  AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
            A   L  + E+A+R +    V+     Q A+        R A   +   R     K  ++
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1570

Query: 549  DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
            ++         AQL + A R   +  +A     + +  L+  + +  EA+
Sbjct: 1571 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)

Query: 224  EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
            EE ++     V+  +    I E ++ L+ +S  E    ++  EA +R+   I+ ++   +
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444

Query: 282  GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
              L       G A GE QA+R   +EA    +  +  A + RR++    +   Q      
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1501

Query: 337  DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
            +L +R +  +  A +K Q+  Q L+ L  + E A R+L      +Q+  ++    Q  L 
Sbjct: 1502 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1554

Query: 397  DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
                  E E Q + A + A K A+L           RSL E     ++L +   +     
Sbjct: 1555 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1603

Query: 457  PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
             EA    ++    L+  Q K N A+     A+        A    E + E+A+R      
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1663

Query: 505  --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
              +   V  R + +  +  +  +AEG     +        L A+ ++ +Q    L +  A
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
            R + E+  A     +L+  L  ++A M+     +A  +E S   S+ +           +
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1783

Query: 608  LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
             LA  A        +A  + ++ +E AA     + ++   AEK AA+G A +   E    
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1841

Query: 662  ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
                +A  +  R L        R L        A   E    ++      +E+  GLV++
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901

Query: 716  AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
             +  +  ++    A+K   +K     A ++ ++  + + A    R   +  L A  +R++
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961

Query: 772  ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
               E+ + REA +                 K++A        +K+ L+   R+   V + 
Sbjct: 1962 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2007

Query: 832  REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
            R   +  E +         QL+L  E A  +                EEK   F  Q+  
Sbjct: 2008 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2048

Query: 892  EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
            + + Q +        QL  EA   +++     AE    V AE +AA +            
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2097

Query: 949  YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
             E E L   + +         AAA+ L +EA + +++      AA R      AEM +  
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157

Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
            +    T R   Q  +++                  +E+ RL  E  +    +       Q
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2211

Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
            V E + ++  Q++ LS +KA +        + D+++ Q    L   A+ + Q  +E  R 
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2269

Query: 1109 AEAA 1112
            + AA
Sbjct: 2270 SVAA 2273



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)

Query: 330  QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
            ++ +  A L  + Q +   A  KAQ   +  ++     E   R+ EA  +++Q       
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1402

Query: 390  AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
            + Q  L       E E Q +   AEA + + L  + + R   L+          + GE+ 
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1462

Query: 440  ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
            AL ++  +   Q +    EA  L +QV    Q            ++ +   A    R  +
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522

Query: 489  AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
            A   L  + E+A+R +    V+     Q A+        R A   +   R     K  ++
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1578

Query: 549  DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
            ++         AQL + A R   +  +A     + +  L+  + +  EA+
Sbjct: 1579 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1628


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 196/964 (20%), Positives = 361/964 (37%), Gaps = 150/964 (15%)

Query: 224  EEALKNRNFTVE--KMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAK 281
            EE ++     V+  +    I E ++ L+ +S  E    ++  EA +R+   I+ ++   +
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485

Query: 282  GWLRDPSASPGDA-GE-QAIRQILDEAG---KVGELCAGKERREILGTCKMLGQMTDQVA 336
              L       G A GE QA+R   +EA    +  +  A + RR++    +   Q      
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE---V 1542

Query: 337  DLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLA 396
            +L +R +  +  A +K Q+  Q L+ L  + E A R+L      +Q+  ++    Q  L 
Sbjct: 1543 ELASRVKAEAEAAREK-QRALQALEELRLQAEEAERRL------RQAEVERARQVQVALE 1595

Query: 397  DPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDS 456
                  E E Q + A + A K A+L           RSL E     ++L +   +     
Sbjct: 1596 TAQRSAEAELQSKRA-SFAEKTAQL----------ERSLQEEHVAVAQLREEAERRAQQQ 1644

Query: 457  PEARALAKQVATALQNLQTKTNRAVANSRPAK--------AAVHLEGKIEQAQRWI---- 504
             EA    ++    L+  Q K N A+     A+        A    E + E+A+R      
Sbjct: 1645 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRG 1704

Query: 505  --DNPTVDDRGVGQAAI--RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
              +   V  R + +  +  +  +AEG     +        L A+ ++ +Q    L +  A
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQ-----EAMTQEVSDVFSDTTTP--------IK 607
            R + E+  A     +L+  L  ++A M+     +A  +E S   S+ +           +
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR 1824

Query: 608  LLAVAATA----PPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGI-- 661
             LA  A        +A  + ++ +E AA     + ++   AEK AA+G A +   E    
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV--LAEKLAAIGEATRLKTEAEIA 1882

Query: 662  ----QASVKTARELTPQVVSAARILLRNPGNQAA--YEHFETMKNQWIDNVEKMTGLVDE 715
                +A  +  R L        R L        A   E    ++      +E+  GLV++
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942

Query: 716  AIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM--LVAGATSIARRANRILLVA--KREV 771
             +  +  ++    A+K   +K     A ++ ++  + + A    R   +  L A  +R++
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002

Query: 772  ENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKV 831
               E+ + REA +                 K++A        +K+ L+   R+   V + 
Sbjct: 2003 AAEEERRRREAEERVQ--------------KSLAAEEEAARQRKAALEEVERLKAKVEEA 2048

Query: 832  REAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAG 891
            R   +  E +         QL+L  E A  +                EEK   F  Q+  
Sbjct: 2049 RRLRERAEQE------SARQLQLAQEAAQKR-------------LQAEEKAHAFAVQQKE 2089

Query: 892  EVINQPMMM---AARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDD 948
            + + Q +        QL  EA   +++     AE    V AE +AA +            
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAE--AARRAAEEAEEA-RVQAEREAAQS--------RRQV 2138

Query: 949  YEPELLLMPSNQ--PVNQPILAAAQSLHREATKWSSKGNDIIAAAKRMALLM-AEMSRLV 1005
             E E L   + +         AAA+ L +EA + +++      AA R      AEM +  
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198

Query: 1006 RGGSGTKRALIQCAKDIAK--------------ASDEVTRLAKEVAKQCTDKRIRTNLLQ 1051
            +    T R   Q  +++                  +E+ RL  E  +    +       Q
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS------Q 2252

Query: 1052 VCERIPTISTQLKILSTVKATMLGRTN---ISDEESEQATEMLVHNAQNLMQSVKETVRE 1108
            V E + ++  Q++ LS +KA +        + D+++ Q    L   A+ + Q  +E  R 
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKMKQVAEEAARL 2310

Query: 1109 AEAA 1112
            + AA
Sbjct: 2311 SVAA 2314



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 57/290 (19%), Positives = 107/290 (36%), Gaps = 36/290 (12%)

Query: 330  QMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKID 389
            ++ +  A L  + Q +   A  KAQ   +  ++     E   R+ EA  +++Q       
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR---- 1443

Query: 390  AAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILR----------SLGEIS 439
            + Q  L       E E Q +   AEA + + L  + + R   L+          + GE+ 
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1503

Query: 440  ALTSKLADLRRQGKGDSPEARALAKQVATALQ-----------NLQTKTNRAVANSRPAK 488
            AL ++  +   Q +    EA  L +QV    Q            ++ +   A    R  +
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563

Query: 489  AAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRV 548
            A   L  + E+A+R +    V+     Q A+        R A   +   R     K  ++
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALE----TAQRSAEAELQSKRASFAEKTAQL 1619

Query: 549  DQ-------LTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
            ++         AQL + A R   +  +A     + +  L+  + +  EA+
Sbjct: 1620 ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669


>gi|112420968 coiled-coil domain containing 158 [Homo sapiens]
          Length = 1113

 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 146/794 (18%), Positives = 305/794 (38%), Gaps = 88/794 (11%)

Query: 10  ESILEPVAQQISHLVI-MHEEGEVDGK-------AIPDLTAPVAAVQAAVSNLVRVGKET 61
           E +LE  + Q+  L   ++E  E+  K       ++ DL   +  +Q     +  + +  
Sbjct: 77  ERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRE 136

Query: 62  VQTTEDQILKRDMPPAFIKVENA-CTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTS 120
            Q+ ED  L+  +     ++E A C K      ML+     +     ++    G+L    
Sbjct: 137 SQSQED--LRNQLQNTVHELEAAKCLK----EDMLKDSNTQIEQLRKMMLSHEGVLQEIR 190

Query: 121 DLLLTFDEAEVRKIIRV-CKGILEYLT----VAEVVETMEDLVTYTKN-LGPGMTKMAKM 174
            +L+ F+EA  +KI        L + +    +++++  ++  ++Y K  + P   ++  +
Sbjct: 191 SILVDFEEASGKKICEHDSMSTLHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEAL 250

Query: 175 IDERQQELT-----HQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKN 229
             E Q ++      HQ+    L++        L    S+ +    +  S+ + I+E  +N
Sbjct: 251 KSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQMEIIQEQARN 310

Query: 230 RNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSA 289
           +N    +  +++   +  L+    +        TE +++ L   +S+L +A+      S 
Sbjct: 311 QNSMYMRQLSDLESTVSQLRSELREAKRMYEDKTEELEKQLVLANSELTEARTERDQFSQ 370

Query: 290 SPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVA 349
             G+  +Q  + + D   +  EL   KE+ + L        +T  +  LR      +   
Sbjct: 371 ESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSIT--IDHLRRELDNRN--- 425

Query: 350 MQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIR 409
             + Q++   L  L ++ +    +  A    K    +K+ +    L       E  +++ 
Sbjct: 426 -MEVQRLEALLKALKSECQGQMERQMAAIQGKNESLEKVSSLTAQL-------ESTKEML 477

Query: 410 GALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATA 469
             + E     ++  +  ER         IS LT+ L +  R  +  + E   L  +V   
Sbjct: 478 RKVVEELTAKKMTLESSER--------TISDLTTSLQEKERAIEATNAEITKLRSRVDLK 529

Query: 470 LQNLQTKTNRA--VANSRPAKAAVHL-----EGKIEQAQRWIDNPTVDDRGVGQAAIRGL 522
           LQ LQ   N    + N +    A+ L     +  IE  ++ I+N T             L
Sbjct: 530 LQELQHLKNEGDHLRNVQTECEALKLQMTEKDKVIEILRQQIENMT------------QL 577

Query: 523 VAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKD 582
           V +  R A  M     Q  L K   ++    +L +L    + +  + R L +++ D L+ 
Sbjct: 578 VGQHGRTAGAMQVEKAQ--LEK--EINDRRMELKELKILKDKKDAKIRELEARVSD-LEL 632

Query: 583 LKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGA 642
            K ++  A ++ +  V        +LL    T+  +  N  E ++    NF N S ++  
Sbjct: 633 EKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNKSEEMEM 692

Query: 643 TAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQW 702
           T  K      + +S +E  + ++K+        +  A  + +            T K   
Sbjct: 693 TTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQ----------ITAKRGQ 742

Query: 703 IDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM-LVAGATSIARRAN 761
           ID ++     ++EA+      +  +  +K++  K    ++ +  +   +AG   + R   
Sbjct: 743 IDALQSKIQFLEEAMTN---ANKEKHFLKEEKSKLSQELSTVATEKNKMAGELEVLRSQE 799

Query: 762 RILLVAKREVENSE 775
           R L   K +V N E
Sbjct: 800 RRL---KEKVTNME 810


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 123/698 (17%), Positives = 281/698 (40%), Gaps = 109/698 (15%)

Query: 152  ETMEDLVTYTKNLGPGMTKMAKMIDERQQEL--THQEHRVMLVNSMNTVKELLPVLISAM 209
            +T++DL      +  G+ K+   ++++  +L  + ++ + +  +     ++L   L  + 
Sbjct: 1009 QTLDDLQVEEDKVN-GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQ 1067

Query: 210  KIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEI----------IRVLQ--LTSWDEDA 257
            +  +  +N K Q IEE LK + F + ++ A+I++           I+ LQ  +   +E+ 
Sbjct: 1068 ESIMDLENDKQQ-IEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEI 1126

Query: 258  WAS--------KDTEAMKRALASIDSKLNQAKGWL--RDPSASPGDAGEQAIRQILDEAG 307
             A         K    + R L  I  +L +A G    +       +A  Q +R+ L+EA 
Sbjct: 1127 EAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186

Query: 308  KVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKV 367
               E  A   R++   +   LG+  D +  ++              Q++ +    L  ++
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVK--------------QKLEKEKSELKMEI 1232

Query: 368  ENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL--AEAR---KIAELC 422
            ++ A  +EA++ SK +I +     ++  ++     E + Q+   L   +AR   +  EL 
Sbjct: 1233 DDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELS 1292

Query: 423  DDPKERDDILRSLGEI-SALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAV 481
               +E++ ++  L +   ALT +L +L+RQ + ++    A+A  + ++  +         
Sbjct: 1293 HRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL------ 1346

Query: 482  ANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDL 541
                       L  + E+ Q              +A ++  +++ +         Y  D 
Sbjct: 1347 -----------LREQYEEEQE------------AKAELQRALSKANSEVAQWRTKYETDA 1383

Query: 542  LAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDVFSD 601
            + + + +++   +LA      E  +  A +  +    SL+  K R+Q     EV D+  D
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCA----SLEKTKQRLQ----GEVEDLMRD 1435

Query: 602  TTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGT---ANKSTV 658
                 +     AT      N ++V  E     +    +L A  +++ ++ T     ++  
Sbjct: 1436 LE---RSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAY 1492

Query: 659  EGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAID 718
            E +   ++T R             L+   +    +  ET KN  +   EK   LV++   
Sbjct: 1493 EEVVDQLETLRRENKN--------LQEEISDLTEQIAETGKN--LQEAEKTKKLVEQ--- 1539

Query: 719  TKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVE--NSED 776
             KS L  + E ++  L+  +  +  +Q ++     + +    +R ++    E+E      
Sbjct: 1540 EKSDLQVALEEVEGSLEHEESKILRVQLEL-----SQVKSELDRKVIEKDEEIEQLKRNS 1594

Query: 777  PKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQ 814
             +  EA+++  D   ++ +  +   K + G++++  +Q
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQ 1632



 Score = 37.7 bits (86), Expect = 0.062
 Identities = 112/582 (19%), Positives = 207/582 (35%), Gaps = 79/582 (13%)

Query: 173  KMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNF 232
            K  DE+Q +L H  +  M    + T    L   +   +  ++      Q + + L+    
Sbjct: 1264 KAKDEQQTQLIHDLN--MQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKR 1321

Query: 233  TVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPG 292
             +E+ +   N +   LQ +  D D    +  E  + A A +   L++A            
Sbjct: 1322 QMEEETKAKNAMAHALQSSRHDCDL-LREQYEEEQEAKAELQRALSKANS---------- 1370

Query: 293  DAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQK 352
            +  +   +   D   +  EL   K         K L Q   Q A+       S   +++K
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAK---------KKLAQRL-QEAEENTETANSKCASLEK 1420

Query: 353  AQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLAD-PNGGPEGEEQIRGA 411
             +Q  QG      +VE+  R LE    +  ++ KK       LA+      E + ++  A
Sbjct: 1421 TKQRLQG------EVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAA 1474

Query: 412  LAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQ 471
              E+R ++          ++ +       +  +L  LRR+ K    E   L +Q+A   +
Sbjct: 1475 QKESRSLST---------ELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK 1525

Query: 472  NLQ--TKTNRAVANSRP--AKAAVHLEGKIEQAQRWIDNPTVD--------DRGV--GQA 517
            NLQ   KT + V   +     A   +EG +E  +  I    ++        DR V     
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585

Query: 518  AIRGLVAEGHRLANVMMGPYRQDLLAKCDR----------VDQLTAQLADLAARGEGESP 567
             I  L     R A  +      ++ ++ D           ++++  QL     +      
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQK 1645

Query: 568  QARALASQLQDSL----------KDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPP 617
              R +  QL+DS           +DLK ++  A+ +  + +  +    +K +A+  T   
Sbjct: 1646 HLRTVQGQLKDSQLHLDDALRSNEDLKEQL--AIVERRNGLLLEELEEMK-VALEQTERT 1702

Query: 618  DAPNREEVFD--ERAANFENHSGKLGATAEKAAA-VGTANKSTVEGIQASVKTARELTPQ 674
               + +E+ D  +R     + +  L  T +K  A +          IQ S     +    
Sbjct: 1703 RRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKA 1762

Query: 675  VVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEA 716
            +  AA +       Q    H E MK      V+ +   +DEA
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1804



 Score = 32.7 bits (73), Expect = 2.0
 Identities = 90/461 (19%), Positives = 176/461 (38%), Gaps = 50/461 (10%)

Query: 149  EVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISA 208
            EVV+ +E L    KNL   ++ + + I E  + L   E    LV      K  L V +  
Sbjct: 1494 EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQ---EKSDLQVALEE 1550

Query: 209  MKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKR 268
            ++  +  + SK   ++  L      +++   E +E I  L+  S        +  EA++ 
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS-------QRAAEALQS 1603

Query: 269  ALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKML 328
             L   D+++      LR      GD  E              E+  G   R++  T K L
Sbjct: 1604 VL---DAEIRSRNDALRLKKKMEGDLNEM-------------EIQLGHSNRQMAETQKHL 1647

Query: 329  GQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKI 388
              +  Q+ D     Q     A++  + + + L ++  +      +LE M  + +   +  
Sbjct: 1648 RTVQGQLKD----SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTR 1703

Query: 389  DAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEI--------SA 440
              ++  L D +   +       +L   +K  E  D  + + ++  S+ E          A
Sbjct: 1704 RLSEQELLDASDRVQLLHSQNTSLINTKKKLE-ADIAQCQAEVENSIQESRNAEEKAKKA 1762

Query: 441  LT--SKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIE 498
            +T  + +A+  ++ +  S     + K +   +++LQ + +   A     K       K+E
Sbjct: 1763 ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--AEQLALKGGKKQIQKLE 1820

Query: 499  QAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQD---LLAKCDRVDQLTAQL 555
               R ++N    ++  G  A++G   +  R    M     +D   +L   D VD+L A++
Sbjct: 1821 NRVRELENELDVEQKRGAEALKG-AHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKV 1879

Query: 556  ADLAARGEGESPQARALAS---QLQDSLKDLKARMQEAMTQ 593
                 + E    QA    S   ++Q  L++   R   A +Q
Sbjct: 1880 KSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQ 1920


>gi|156938343 talin 2 [Homo sapiens]
          Length = 2542

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 148/764 (19%), Positives = 266/764 (34%), Gaps = 144/764 (18%)

Query: 165  GPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIE 224
            GP    +  M   +QQ +  Q HR  +           P L SA +  + T N+    ++
Sbjct: 462  GPETFNVGSMPSPQQQVMVGQMHRGHM-----------PPLTSAQQALMGTINTSMHAVQ 510

Query: 225  EA----------------LKNRNFTVEKMSAEINEI-----------IRVLQLTSWDEDA 257
            +A                + +R +   K+    +EI             V+ LT+ D   
Sbjct: 511  QAQDDLSELDSLPPLGQDMASRVWVQNKVDESKHEIHSQVDAITAGTASVVNLTAGDP-- 568

Query: 258  WASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGD---AGEQAIRQILDEAGKVGELC- 313
             A  D  A+  A+ +I S L +    ++  +A   D   +GE  +R     AG V +L  
Sbjct: 569  -ADTDYTAVGCAITTISSNLTEMSKGVKLLAALMDDEVGSGEDLLRAARTLAGAVSDLLK 627

Query: 314  -----AGKERREILGTCKMLGQMTDQVADLRARGQGSSP-----VAMQKAQQVSQGLDVL 363
                 +G+ R+ +L     +GQ +  +  LR  G+  +      V M  A+ V+    +L
Sbjct: 628  AVQPTSGEPRQTVLTAAGSIGQASGDL--LRQIGENETDERFQDVLMSLAKAVANAAAML 685

Query: 364  TAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCD 423
              K +N A+  E      + IA     A +                  +A A+ ++    
Sbjct: 686  VLKAKNVAQVAEDTVLQNRVIAAATQCALS--------------TSQLVACAKVVSPTIS 731

Query: 424  DPKERDDILRSLGEISALTSKLADLRRQGKGDSP---EARALAKQVATALQNLQTKTNRA 480
             P  ++ ++ +   +           +    DS    +  A A  V+ AL +L     + 
Sbjct: 732  SPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAASVVSQALHDLLQHVRQF 791

Query: 481  VANSRPAKAAVHLEGKIEQAQRWIDNPT------VDDRGVGQAAIRGLVAEGHRLANVMM 534
             +   P        G+ +QA   I   T      + D G      R L      L N M 
Sbjct: 792  ASRGEPI-------GRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLVNAMR 844

Query: 535  GPYRQD--------LLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAR 586
                 +        LLA    +   TA++ + AA+G   +P+      +L+++ + L+  
Sbjct: 845  SDAEAEIDMENSKKLLAAAKLLADSTARMVE-AAKGAAANPENEDQQQRLREAAEGLRVA 903

Query: 587  MQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEK 646
               A    +          +  L VAA     A  +     + AA    +        + 
Sbjct: 904  TNAAAQNAIKKKI------VNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQLVQS 957

Query: 647  AAAVGTANKSTVEGIQASVKTARELTPQV----------------VSAARILLRNPGNQA 690
              AV       V+G++ S   A +L+ Q+                VS+A+  +    +QA
Sbjct: 958  CKAVADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQA 1017

Query: 691  AYEHF-ETMKNQWIDNVEKMTGL-----------VDEAIDT-----KSLLDASEEAIKKD 733
            A     +  KN      E  T             +D A++T       L DA   A++  
Sbjct: 1018 AAMQLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAVESQ 1077

Query: 734  LDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKT 793
            L            Q L + + ++     ++L  A +  E+      RE  +A        
Sbjct: 1078 LKPLPGETLEKCAQDLGSTSKAVGSSMAQLLTCAAQGNEHYTGVAARETAQA-------- 1129

Query: 794  ISPMVMDAKAVAGNISDPGLQKSFLDSGYRIL-GAVAKVREAFQ 836
            +  +   A+ VA + +DP    + LDS   ++ G+   ++EA Q
Sbjct: 1130 LKTLAQAARGVAASTTDPAAAHAMLDSARDVMEGSAMLIQEAKQ 1173



 Score = 39.3 bits (90), Expect = 0.021
 Identities = 26/94 (27%), Positives = 48/94 (51%)

Query: 748 MLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGN 807
           +L++ A ++A  A  ++L AK   + +ED   +  V AA+ + + + S +V  AK V+  
Sbjct: 670 VLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLVACAKVVSPT 729

Query: 808 ISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPD 841
           IS P  Q+  +++G  +  +V     A Q    D
Sbjct: 730 ISSPVCQEQLIEAGKLVDRSVENCVRACQAATTD 763



 Score = 38.1 bits (87), Expect = 0.048
 Identities = 102/515 (19%), Positives = 179/515 (34%), Gaps = 88/515 (17%)

Query: 404  GEEQIRGALAEARKIAELCD-----DPKERDDILRSLGEISALTSKLADLRRQGKGDSPE 458
            GE+ +R A   A  +++L         + R  +L + G I   +  L  LR+ G+ ++ E
Sbjct: 608  GEDLLRAARTLAGAVSDLLKAVQPTSGEPRQTVLTAAGSIGQASGDL--LRQIGENETDE 665

Query: 459  ARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQA- 517
                        Q++     +AVAN     AA  L  K +   +  ++  + +R +  A 
Sbjct: 666  R----------FQDVLMSLAKAVAN-----AAAMLVLKAKNVAQVAEDTVLQNRVIAAAT 710

Query: 518  ----AIRGLVAEGHRLANVMMGPYRQDLLAKC----DRVDQLTAQLADLAARGEGESPQA 569
                +   LVA    ++  +  P  Q+ L +     DR  +   +    A        Q 
Sbjct: 711  QCALSTSQLVACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQV 770

Query: 570  RALASQLQDSLKDLKARMQE-------------------AMTQEVSDVFSDTTTPIKLLA 610
             A AS +  +L DL   +++                    +T+ +     D    ++   
Sbjct: 771  SAAASVVSQALHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQAR 830

Query: 611  VAATAPPDAPNREEVFDERAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARE 670
            V A A  D  N      E   + EN    L                      A+ K   +
Sbjct: 831  VLAQATSDLVNAMRSDAEAEIDMENSKKLL----------------------AAAKLLAD 868

Query: 671  LTPQVVSAARILLRNPGNQ-------AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLL 723
             T ++V AA+    NP N+        A E      N    N  K   +    +  K   
Sbjct: 869  STARMVEAAKGAAANPENEDQQQRLREAAEGLRVATNAAAQNAIKKKIVNRLEVAAKQAA 928

Query: 724  DASEEAIKKDLDKCKVAMANIQP---QMLVAGATSIARRANRILLVAKREVENSEDPKFR 780
             A+ + I    +    A++N  P   Q LV    ++A    +++   +     +ED   +
Sbjct: 929  AAATQTIAASQN---AAVSNKNPAAQQQLVQSCKAVADHIPQLVQGVRGSQAQAEDLSAQ 985

Query: 781  EAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP 840
             A+  +S    +  S MV  AKA    +SD             +  ++A++R A Q    
Sbjct: 986  LALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAAMQLSQCAKNLATSLAELRTASQKAHE 1045

Query: 841  DFPPPPPD--LEQLR-LTDELAPPKPPLPEGEVPP 872
               P   D  L  ++ L +EL   K    E ++ P
Sbjct: 1046 ACGPMEIDSALNTVQTLKNELQDAKMAAVESQLKP 1080



 Score = 34.7 bits (78), Expect = 0.53
 Identities = 76/390 (19%), Positives = 160/390 (41%), Gaps = 58/390 (14%)

Query: 134  IIRVCKGILE--YLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQ--EHRV 189
            I++  K ++E   L V+    T + L    ++    +T++A+++      L     E +V
Sbjct: 2020 ILKTAKALVEDTKLLVSGAASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQV 2079

Query: 190  MLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEE-ALKNRNFTVEKMSAEINEIIRVL 248
            +L+N++  V + L  LISA      TK + ++ +++ ++       + M   +  +++ +
Sbjct: 2080 VLINAIKDVAKALSDLISA------TKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTV 2133

Query: 249  QLTSWDEDAWASKDTEAMKRALASIDSKLN--QAKGWLRDPSASPGDA--GEQAIRQILD 304
            +    DE   A++ T A++  +  I  +L   Q+K  + + ++SP ++    + I     
Sbjct: 2134 KAVE-DE---ATRGTRALEATIECIKQELTVFQSKD-VPEKTSSPEESIRMTKGITMATA 2188

Query: 305  EAGKVGELC-----------AGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKA 353
            +A   G  C           + K   ++L  CK      D   ++R R       A++  
Sbjct: 2189 KAVAAGNSCRQEDVIATANLSRKAVSDMLTACKQASFHPDVSDEVRTR-------ALRFG 2241

Query: 354  QQVSQG-LDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL 412
             + + G LD+L   +    +          + +K++  A   L                 
Sbjct: 2242 TECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVAGAVTELIQ--------------A 2287

Query: 413  AEARKIAELCD--DPK--ERDDILRSLGEISALTSKLADLRRQGK-GDSPEARALAKQVA 467
            AEA K  E  D  DP      ++L +   I A   KL  L+ + K   + E     +Q+ 
Sbjct: 2288 AEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADETLDFEEQIL 2347

Query: 468  TALQNLQTKTNRAVANSRPAKAAVHLEGKI 497
             A +++   T+  V ++  A+  +  +GK+
Sbjct: 2348 EAAKSIAAATSALVKSASAAQRELVAQGKV 2377



 Score = 30.4 bits (67), Expect = 10.0
 Identities = 35/157 (22%), Positives = 64/157 (40%), Gaps = 23/157 (14%)

Query: 981  SSKGNDIIAAAKRMALLMAEMSRLVRGGSG--------TKRALIQCAKDIAKASDEVTRL 1032
            +S  + +  AA+  A  + +++ +V+ G+         T+  LI   KD+AKA  ++   
Sbjct: 2039 ASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISA 2098

Query: 1033 AKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLV 1092
             K  A +  D      L    + + T  T L  L TVKA         ++E+ + T  L 
Sbjct: 2099 TKGAASKPVDDPSMYQLKGAAKVMVTNVTSL--LKTVKAV--------EDEATRGTRALE 2148

Query: 1093 HNAQNLMQSV-----KETVREAEAASIKIRTDAGFTL 1124
               + + Q +     K+   +  +    IR   G T+
Sbjct: 2149 ATIECIKQELTVFQSKDVPEKTSSPEESIRMTKGITM 2185


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 111/622 (17%), Positives = 246/622 (39%), Gaps = 90/622 (14%)

Query: 59   KETVQTTEDQI-LKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILS 117
            KE  +  ED+  +  ++     K+E+ C++L +    L+     V    +  +     + 
Sbjct: 926  KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK---VK 982

Query: 118  GTSDLLLTFDEAEVRKIIRVCKGILE-YLTVAEVVETMEDLVTYTKNLGPGMTKMAKMID 176
              ++ +   DE  + K+ +  K + E +    + ++  ED V     L     K+ + +D
Sbjct: 983  NLTEEMAGLDET-IAKLTKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQVD 1038

Query: 177  ERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEK 236
            + +  L  ++ + + ++     ++L   L  A +  +  +N K Q ++E LK + F +  
Sbjct: 1039 DLEGSL--EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ-LDEKLKKKEFEISN 1095

Query: 237  MSAEINEI----------IRVLQ--LTSWDED--------AWASKDTEAMKRALASIDSK 276
            + ++I +           I+ LQ  +   +E+        A A K    + R L  I  +
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155

Query: 277  LNQAKGWL--RDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQ 334
            L +A G    +       +A  Q +R+ L+EA    E  A   R++   +   LG+  D 
Sbjct: 1156 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215

Query: 335  VADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNW 394
            +  ++              Q++ +    +  ++++ A  +E ++ +K ++ K     ++ 
Sbjct: 1216 LQRVK--------------QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261

Query: 395  LADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKG 454
            L++     E ++++   L   R   +      E  +  R L E  AL S+L+    +GK 
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQ-----TESGEFSRQLDEKEALVSQLS----RGK- 1311

Query: 455  DSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVH----LEGKIEQAQRWIDNPTVD 510
                 +A  +Q+    + L+ +     A +   +++ H    L  + E+ Q         
Sbjct: 1312 -----QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE-------- 1358

Query: 511  DRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQAR 570
                 +A ++  +++ +         Y  D + + + +++   +LA      E       
Sbjct: 1359 ----SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414

Query: 571  ALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERA 630
            A  +    SL+  K R+Q     EV D+  D     +  A  A       N +++  E  
Sbjct: 1415 AKCA----SLEKTKQRLQ----NEVEDLMLDVE---RTNAACAALDKKQRNFDKILAEWK 1463

Query: 631  ANFENHSGKLGATAEKAAAVGT 652
               E    +L A+ ++A ++GT
Sbjct: 1464 QKCEETHAELEASQKEARSLGT 1485



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 62/297 (20%), Positives = 128/297 (43%), Gaps = 29/297 (9%)

Query: 308  KVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKV 367
            K+  L    E  + + T K   +   ++ D  A+ +       +K   + +  + L  +V
Sbjct: 841  KIKPLLKSAETEKEMATMK---EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897

Query: 368  ENAARKL-EAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL-AEARKIAELCDD- 424
            +  A  L +A     Q I  KI      + +     E EE+I   L A+ RK+ + C + 
Sbjct: 898  QAEAEGLADAEERCDQLIKTKIQLEAK-IKEVTERAEDEEEINAELTAKKRKLEDECSEL 956

Query: 425  PKERDDILRSLGEISA-----------LTSKLADLRRQGKGDSPEARALAKQVATALQNL 473
             K+ DD+  +L ++             LT ++A L       + E +AL +     L +L
Sbjct: 957  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016

Query: 474  QTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGH-RLANV 532
            Q + ++    +   KA + LE +++  +  ++        + +A  +    EG  +LA  
Sbjct: 1017 QAEEDKV---NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK---LEGDLKLAQE 1070

Query: 533  MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQE 589
             +     +     +++ +   ++++L ++ E E    +AL  QLQ  +K+L+AR++E
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE----QALGIQLQKKIKELQARIEE 1123



 Score = 34.7 bits (78), Expect = 0.53
 Identities = 80/437 (18%), Positives = 155/437 (35%), Gaps = 79/437 (18%)

Query: 426  KERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSR 485
            K +D++ +S  +   L  K+  L ++      + +A A+ +A A +             +
Sbjct: 864  KIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD----------Q 913

Query: 486  PAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDL---- 541
              K  + LE KI++         V +R   +  I   +    R         ++D+    
Sbjct: 914  LIKTKIQLEAKIKE---------VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 542  --LAKCDR--------VDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
              LAK ++        V  LT ++A L       + + +AL    Q +L DL+A   +  
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024

Query: 592  T---------QEVSDVFSDTTTPIKL--------------LAVAATAPPDAPNREEVFDE 628
            T         Q+V D+        KL              L +A  +  D  N ++  DE
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084

Query: 629  RAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGN 688
            +    E     L +  E   A+G   +  ++ +QA ++   E   +   A+R       +
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE-EIEAERASRAKAEKQRS 1143

Query: 689  QAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM 748
              + E  E       + +E+  G     I+     +A  + +++DL++  +        +
Sbjct: 1144 DLSRELEEIS-----ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1198

Query: 749  LVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNI 808
                A S+A    +I                 + ++    +L K  S M M+   +A N+
Sbjct: 1199 RKKHADSVAELGEQI-----------------DNLQRVKQKLEKEKSEMKMEIDDLASNV 1241

Query: 809  SDPGLQKSFLDSGYRIL 825
                  K  L+   R L
Sbjct: 1242 ETVSKAKGNLEKMCRTL 1258



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 54/254 (21%), Positives = 98/254 (38%), Gaps = 45/254 (17%)

Query: 224  EEALKNRNFTVEK----MSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALA-------- 271
            +E LK +   VE+    + AEI E+   L+ T         +  +A +R           
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1729

Query: 272  -----SIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCK 326
                  +++ ++Q +G + D      +A E+A + I D A    EL   KE+       +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLER 1787

Query: 327  MLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAA--------------- 371
            M   M   V DL+ R   +  +A++  ++  Q L+    ++E                  
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847

Query: 372  ---RKLEAMTNSKQSIAKKIDAAQNWL--------ADPNGGPEGEEQIRGALAEARKIAE 420
               R+++ +T   +   K I   Q+ +        +      E EEQ    LA+ RK+  
Sbjct: 1848 KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQH 1907

Query: 421  LCDDPKERDDILRS 434
              ++ +ER DI  S
Sbjct: 1908 ELEEAEERADIAES 1921


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 111/622 (17%), Positives = 246/622 (39%), Gaps = 90/622 (14%)

Query: 59   KETVQTTEDQI-LKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILS 117
            KE  +  ED+  +  ++     K+E+ C++L +    L+     V    +  +     + 
Sbjct: 926  KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK---VK 982

Query: 118  GTSDLLLTFDEAEVRKIIRVCKGILE-YLTVAEVVETMEDLVTYTKNLGPGMTKMAKMID 176
              ++ +   DE  + K+ +  K + E +    + ++  ED V     L     K+ + +D
Sbjct: 983  NLTEEMAGLDET-IAKLTKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQVD 1038

Query: 177  ERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEK 236
            + +  L  ++ + + ++     ++L   L  A +  +  +N K Q ++E LK + F +  
Sbjct: 1039 DLEGSL--EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ-LDEKLKKKEFEISN 1095

Query: 237  MSAEINEI----------IRVLQ--LTSWDED--------AWASKDTEAMKRALASIDSK 276
            + ++I +           I+ LQ  +   +E+        A A K    + R L  I  +
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155

Query: 277  LNQAKGWL--RDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQ 334
            L +A G    +       +A  Q +R+ L+EA    E  A   R++   +   LG+  D 
Sbjct: 1156 LEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDN 1215

Query: 335  VADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNW 394
            +  ++              Q++ +    +  ++++ A  +E ++ +K ++ K     ++ 
Sbjct: 1216 LQRVK--------------QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQ 1261

Query: 395  LADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKG 454
            L++     E ++++   L   R   +      E  +  R L E  AL S+L+    +GK 
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQ-----TESGEFSRQLDEKEALVSQLS----RGK- 1311

Query: 455  DSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVH----LEGKIEQAQRWIDNPTVD 510
                 +A  +Q+    + L+ +     A +   +++ H    L  + E+ Q         
Sbjct: 1312 -----QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE-------- 1358

Query: 511  DRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQAR 570
                 +A ++  +++ +         Y  D + + + +++   +LA      E       
Sbjct: 1359 ----SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414

Query: 571  ALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERA 630
            A  +    SL+  K R+Q     EV D+  D     +  A  A       N +++  E  
Sbjct: 1415 AKCA----SLEKTKQRLQ----NEVEDLMLDVE---RTNAACAALDKKQRNFDKILAEWK 1463

Query: 631  ANFENHSGKLGATAEKAAAVGT 652
               E    +L A+ ++A ++GT
Sbjct: 1464 QKCEETHAELEASQKEARSLGT 1485



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 62/297 (20%), Positives = 128/297 (43%), Gaps = 29/297 (9%)

Query: 308  KVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKV 367
            K+  L    E  + + T K   +   ++ D  A+ +       +K   + +  + L  +V
Sbjct: 841  KIKPLLKSAETEKEMATMK---EEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 897

Query: 368  ENAARKL-EAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL-AEARKIAELCDD- 424
            +  A  L +A     Q I  KI      + +     E EE+I   L A+ RK+ + C + 
Sbjct: 898  QAEAEGLADAEERCDQLIKTKIQLEAK-IKEVTERAEDEEEINAELTAKKRKLEDECSEL 956

Query: 425  PKERDDILRSLGEISA-----------LTSKLADLRRQGKGDSPEARALAKQVATALQNL 473
             K+ DD+  +L ++             LT ++A L       + E +AL +     L +L
Sbjct: 957  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1016

Query: 474  QTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGH-RLANV 532
            Q + ++    +   KA + LE +++  +  ++        + +A  +    EG  +LA  
Sbjct: 1017 QAEEDKV---NTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRK---LEGDLKLAQE 1070

Query: 533  MMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQE 589
             +     +     +++ +   ++++L ++ E E    +AL  QLQ  +K+L+AR++E
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE----QALGIQLQKKIKELQARIEE 1123



 Score = 34.7 bits (78), Expect = 0.53
 Identities = 80/437 (18%), Positives = 155/437 (35%), Gaps = 79/437 (18%)

Query: 426  KERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSR 485
            K +D++ +S  +   L  K+  L ++      + +A A+ +A A +             +
Sbjct: 864  KIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD----------Q 913

Query: 486  PAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDL---- 541
              K  + LE KI++         V +R   +  I   +    R         ++D+    
Sbjct: 914  LIKTKIQLEAKIKE---------VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 964

Query: 542  --LAKCDR--------VDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAM 591
              LAK ++        V  LT ++A L       + + +AL    Q +L DL+A   +  
Sbjct: 965  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1024

Query: 592  T---------QEVSDVFSDTTTPIKL--------------LAVAATAPPDAPNREEVFDE 628
            T         Q+V D+        KL              L +A  +  D  N ++  DE
Sbjct: 1025 TLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDE 1084

Query: 629  RAANFENHSGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGN 688
            +    E     L +  E   A+G   +  ++ +QA ++   E   +   A+R       +
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEE-EIEAERASRAKAEKQRS 1143

Query: 689  QAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQM 748
              + E  E       + +E+  G     I+     +A  + +++DL++  +        +
Sbjct: 1144 DLSRELEEIS-----ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1198

Query: 749  LVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNI 808
                A S+A    +I                 + ++    +L K  S M M+   +A N+
Sbjct: 1199 RKKHADSVAELGEQI-----------------DNLQRVKQKLEKEKSEMKMEIDDLASNV 1241

Query: 809  SDPGLQKSFLDSGYRIL 825
                  K  L+   R L
Sbjct: 1242 ETVSKAKGNLEKMCRTL 1258



 Score = 34.3 bits (77), Expect = 0.69
 Identities = 54/254 (21%), Positives = 98/254 (38%), Gaps = 45/254 (17%)

Query: 224  EEALKNRNFTVEK----MSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALA-------- 271
            +E LK +   VE+    + AEI E+   L+ T         +  +A +R           
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1729

Query: 272  -----SIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCK 326
                  +++ ++Q +G + D      +A E+A + I D A    EL   KE+       +
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEEL--KKEQDTSAHLER 1787

Query: 327  MLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAA--------------- 371
            M   M   V DL+ R   +  +A++  ++  Q L+    ++E                  
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847

Query: 372  ---RKLEAMTNSKQSIAKKIDAAQNWL--------ADPNGGPEGEEQIRGALAEARKIAE 420
               R+++ +T   +   K I   Q+ +        +      E EEQ    LA+ RK+  
Sbjct: 1848 KHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQH 1907

Query: 421  LCDDPKERDDILRS 434
              ++ +ER DI  S
Sbjct: 1908 ELEEAEERADIAES 1921


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 144/748 (19%), Positives = 279/748 (37%), Gaps = 95/748 (12%)

Query: 143  EYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLV---------- 192
            E  T  E+ +    L   T +L   + ++   IDE + +L  +E  +             
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH 1105

Query: 193  --NSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQL 250
              N++  V+EL   +    + F + K S+N+    A K +    E++ A   E+   L  
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESEKASRNK----AEKQKRDLSEELEALKTELEDTLDT 1161

Query: 251  TSWDEDAWASKDTEA--MKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGK 308
            T+  ++    ++ E   +K+AL   ++K ++A+  ++D       A E+   Q+      
Sbjct: 1162 TAAQQELRTKREQEVAELKKALEE-ETKNHEAQ--IQDMRQRHATALEELSEQLEQAKRF 1218

Query: 309  VGELCAGKE-----RREILGTCKMLGQ-----------MTDQVADLRAR---GQGSSPVA 349
               L   K+      +E+    K+L Q           +  QV +L A+   G       
Sbjct: 1219 KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVEL 1278

Query: 350  MQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEG-EEQI 408
             +KA ++   LD ++  +E A +K         S+  ++   Q  L +          +I
Sbjct: 1279 AEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRI 1338

Query: 409  RGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARALAKQVAT 468
            R    E   + E  ++ +E    L    ++ AL S+LAD +++   D     +L +    
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEK--QVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396

Query: 469  ALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHR 528
             L++ +  + R       A A   LE    + Q+ +D+ TVD     Q A          
Sbjct: 1397 LLKDAEALSQRL---EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA---------- 1443

Query: 529  LANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQ 588
                       +L  K  + DQL A+   ++AR   E  +A A A + +     L   ++
Sbjct: 1444 ----------SNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493

Query: 589  EAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNR------------EEVFDERAANFENH 636
            EA+  E  + F      ++       +  D   +            E+  +E     E  
Sbjct: 1494 EAL--EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551

Query: 637  SGKLGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGN-QAAYEHF 695
              +L AT +    +    ++     +  ++T  E   Q     R+L++     +A  E  
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE---QNEEKKRLLIKQVRELEAELEDE 1608

Query: 696  ETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATS 755
               +   + + +KM       ID K  L+A  EA  K  D+    +  +Q QM       
Sbjct: 1609 RKQRALAVASKKKM------EIDLKD-LEAQIEAANKARDEVIKQLRKLQAQMKDYQREL 1661

Query: 756  IARRANRILLVAKREVENSEDPKFREAVKAASDELS---KTISPMVMDAKAVAGNISDPG 812
               RA+R  + A+ +    +       +    +EL+   +       +   +A  I++  
Sbjct: 1662 EEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSA 1721

Query: 813  LQKS-FLDSGYRILGAVAKVREAFQPQE 839
              KS  LD   R+   +A++ E  + ++
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEEQ 1749



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 66/310 (21%), Positives = 127/310 (40%), Gaps = 40/310 (12%)

Query: 316  KERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLE 375
            ++ +++L    +L +      +L A  +        K Q++ + L  L ++VE    + +
Sbjct: 880  RKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQ 939

Query: 376  AMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDD-PKERDDILRS 434
             + N K+ +   I   +  L D   G   + Q+    AEA KI ++ ++     D   + 
Sbjct: 940  ILQNEKKKMQAHIQDLEEQL-DEEEGARQKLQLEKVTAEA-KIKKMEEEILLLEDQNSKF 997

Query: 435  LGEISALTSKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVAN-SRPAKAAVHL 493
            + E   +  ++A+   Q   +  +A+ LAK        ++ K    +++     K     
Sbjct: 998  IKEKKLMEDRIAECSSQLAEEEEKAKNLAK--------IRNKQEVMISDLEERLKKEEKT 1049

Query: 494  EGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDR------ 547
              ++E+A+R +D  T D +   Q A      +  +L         Q  LA+ D       
Sbjct: 1050 RQELEKAKRKLDGETTDLQ--DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107

Query: 548  -----VDQLTAQLADL--------AARGEGE------SPQARALASQLQDSLKDLKARMQ 588
                 V +L AQ+A+L        A+R + E      S +  AL ++L+D+L D  A  Q
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL-DTTAAQQ 1166

Query: 589  EAMTQEVSDV 598
            E  T+   +V
Sbjct: 1167 ELRTKREQEV 1176


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 56/229 (24%), Positives = 90/229 (39%), Gaps = 46/229 (20%)

Query: 690 AAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEA------IKKDLDKCKVAMAN 743
           A  E  ET KN  ++++E++   V  A+ T+ L DA  E+      ++K L + +  +  
Sbjct: 386 ALLEDTET-KNAVLEHMEELQEQV--ALLTERLRDAENESMAKIAELEKQLSQARKELET 442

Query: 744 IQPQMLVAGATSIARR----------ANRILLVAKREVENSEDPKFREAVKAASDELSKT 793
           ++ +   + A   +RR          A       + +VE  E+      ++   D +S  
Sbjct: 443 LRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIE 502

Query: 794 ISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLR 853
           I P+ + A    G+   PG+                 +  A +P     PPPPP L  L 
Sbjct: 503 ILPVAV-ATPSGGDAPTPGVPTG---------SPSPDLAPAAEPAPGAAPPPPPPLPGLP 552

Query: 854 LTDEL----------------APPKPPLPEGEVPPPRPPPPEEKDEEFP 886
              E                  PP PPLP G++PPP PPPP     + P
Sbjct: 553 SPQEAPPSAPPQAPPLPGSPEPPPAPPLP-GDLPPPPPPPPPPPGTDGP 600



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 22/47 (46%), Positives = 25/47 (53%), Gaps = 11/47 (23%)

Query: 837 PQEPDFPPPPPDLEQLRLTDELAPPKPPLP-----EGEVPPPRPPPP 878
           P  P+ PP PP      L  +L PP PP P     +G VPPP PPPP
Sbjct: 569 PGSPEPPPAPP------LPGDLPPPPPPPPPPPGTDGPVPPPPPPPP 609



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 31/115 (26%), Positives = 44/115 (38%), Gaps = 8/115 (6%)

Query: 859 APPKPPLPEGEVP--PPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSS-- 914
           A  +PP PE   P  P RP   E K EE  E+    ++  P    + ++   A    S  
Sbjct: 455 ASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGG 514

Query: 915 ---KPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQPVNQPI 966
               PG+P       +   A+ A  A  P PP +     P+    PS  P   P+
Sbjct: 515 DAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQ-EAPPSAPPQAPPL 568


>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
          Length = 1146

 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 88/409 (21%), Positives = 159/409 (38%), Gaps = 63/409 (15%)

Query: 235  EKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDA 294
            EK+  E+   IR L+      +  A+ + EA      + +++  + +  +R+   S    
Sbjct: 719  EKLQVELETRIRGLEEALRQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGASG 778

Query: 295  G------------EQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARG 342
            G            EQA   + D   ++ EL       E    C    + +  +A+  ARG
Sbjct: 779  GGGGDTTQLRAALEQAREDLRDRDSRLREL-------EAASACLDEARASRLLAEEEARG 831

Query: 343  QGSSPVAMQKAQ-QVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGG 401
              +     ++A+ + S+ L+VL  ++  A    E    +   + +  DAA+  +A+    
Sbjct: 832  LRAELAQREEARLEQSRELEVLREQLATARATGEQQRTAAAELGRARDAAEARVAEL--- 888

Query: 402  PEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGDSPEARA 461
            P   E+ R  LAE R+ +E       R  ++ +  E   L  +  +LR +      E  A
Sbjct: 889  PAACEEARQGLAELREASEAL-----RQSVVPA-SEHRRLQEEALELRGRAASLEQEVVA 942

Query: 462  LAKQVATALQNLQTKTNRAVANSRPAKAA-------VHLEGKIEQAQRWIDNPTVD---- 510
              K+ A     L+ +   +VA S   +           LEG++E+  R  +  + +    
Sbjct: 943  TGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRRHEKTSAEVFQV 1002

Query: 511  ---------DRGVGQAAI-------RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQ 554
                     +R   +A +       RGL  E  R          Q+ L K    D+   +
Sbjct: 1003 QREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQAQSRA--QEALDKAKEKDKKITE 1060

Query: 555  LA-DLAARGEGESPQARALASQ----LQDSLKDLKARMQEAMTQEVSDV 598
            L+ ++    E    Q  ALA+     L+D +KDL+ ++QEA     S V
Sbjct: 1061 LSKEVFNLKEALKEQPAALATPEVEALRDQVKDLQQQLQEAARDHSSVV 1109


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 83/390 (21%), Positives = 158/390 (40%), Gaps = 48/390 (12%)

Query: 154  MEDLVTYTKNLGPGMTKMAKM---IDERQQEL-THQEHRVMLVNSMNTVKELLPVLISAM 209
            MEDL++   ++G  + ++ K    ++++ +E+ T  E     + +    K  L V + AM
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565

Query: 210  KI-FVTTKNSKNQGIEEALKNRNFTVEKMSAEINE----------IIRVLQLTSWDEDAW 258
            K  F      +++  EE  K     V +M AE+ +            + L++   D +A 
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625

Query: 259  ---ASKDTEAMKRALASIDSKLNQAKGWLRDPSASPGDA------GEQAIRQILDEAGKV 309
               A+K+ +   + L  + +++      L D  AS  +        E+ ++ +  E  ++
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685

Query: 310  GELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVEN 369
             E  A  ER +     +   Q  D++AD  A   G   +A+++ +++   +  L  ++E 
Sbjct: 1686 QEELAAAERAK-----RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740

Query: 370  AARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERD 429
                 E + +  +    +ID     L       +  E  R  L    K  EL    +E +
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK--ELKVKLQEME 1798

Query: 430  DILRSL--GEISALTSKLADLRRQGKGDSPEARALAKQVATALQNL-------------- 473
              ++S     I+AL +K+A L  Q   ++ E +A  KQV    + L              
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNA 1858

Query: 474  -QTKTNRAVANSRPAKAAVHLEGKIEQAQR 502
             Q K     A++R  +    LE   E+AQR
Sbjct: 1859 EQYKDQADKASTRLKQLKRQLEEAEEEAQR 1888



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 119/598 (19%), Positives = 234/598 (39%), Gaps = 82/598 (13%)

Query: 227  LKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRD 286
            LK RN+   ++  ++  +++V    S  E+   +K+ E +K     +  K   A+  L +
Sbjct: 820  LKLRNWQWWRLFTKVKPLLQV----SRQEEEMMAKEEELVK-----VREKQLAAENRLTE 870

Query: 287  PSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSS 346
                      + + Q+ ++     ELCA  E      T K   ++ +   DL AR +   
Sbjct: 871  METLQSQLMAEKL-QLQEQLQAETELCAEAEELRARLTAKKQ-ELEEICHDLEARVEEEE 928

Query: 347  P------VAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNG 400
                      +K QQ  Q L+    + E+A +KL+    + ++  KK++  Q  L D N 
Sbjct: 929  ERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC 988

Query: 401  GPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEI-SALTSKLADLRRQGKGDSPEA 459
                E++    L E R IAE   +  E ++  +SL ++ +   + + DL  + + +  + 
Sbjct: 989  KLAKEKK----LLEDR-IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQR 1043

Query: 460  RALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAI 519
            + L K     L+   T  +  +A  +   A    E K++ A++  +      R   +AA 
Sbjct: 1044 QELEK-TRRKLEGDSTDLSDQIAELQAQIA----ELKMQLAKKEEELQAALARVEEEAAQ 1098

Query: 520  RGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDS 579
            + +  +  R     +   ++DL ++    ++   Q  DL   GE    +  AL ++L+D+
Sbjct: 1099 KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDL---GE----ELEALKTELEDT 1151

Query: 580  LKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGK 639
            L D  A  QE  ++   +V            +  T   +A   E    E     + HS  
Sbjct: 1152 L-DSTAAQQELRSKREQEV----------NILKKTLEEEAKTHEAQIQEMR---QKHSQA 1197

Query: 640  LGATAEKAAAVGTANKSTVEGIQASVKTARELTPQVVSAARILLRNPGN----------- 688
            +   AE+        K     ++ + +T      ++ +  ++LL+  G+           
Sbjct: 1198 VEELAEQL----EQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253

Query: 689  ----QAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANI 744
                Q  +   E ++ +  D V K+   +D      S  D+    + KD    +  + + 
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313

Query: 745  QPQMLVAGATSIARRANRILLVAKREVENSEDPK--FREAV---KAASDELSKTISPM 797
            Q          + +  NR  L    +++  ED K  FRE +   + A   L K I+ +
Sbjct: 1314 Q---------ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362



 Score = 38.5 bits (88), Expect = 0.037
 Identities = 90/454 (19%), Positives = 187/454 (41%), Gaps = 67/454 (14%)

Query: 170  KMAKMIDERQQELTHQEHRVMLVN-SMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALK 228
            ++AK  +E Q  L   E      N ++  ++EL   +    +   + + S+N+    A K
Sbjct: 1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNK----AEK 1132

Query: 229  NRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKDTEA--MKRALASIDSKLNQAKGWLRD 286
             +    E++ A   E+   L  T+  ++  + ++ E   +K+ L   ++K ++A+  +++
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE-EAKTHEAQ--IQE 1189

Query: 287  PSASPGDAGEQAIRQILDEAGKVGELCAGK-----ERREILGTCKMLGQ----------- 330
                   A E+   Q+         L   K     ER E+    K+L Q           
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249

Query: 331  MTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDA 390
            +  Q+ +L+ +      V  + A +V++    L  +++N    L    +    + K   A
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTK----LQVELDNVTGLLSQSDSKSSKLTKDFSA 1305

Query: 391  AQNWLADPNGGPEGEEQIRGALAEARKIAELCDDP-------KERDDILRSLG-EISALT 442
             ++ L D       +E+ R  L+ + K+ ++ D+        +E ++   +L  +I+ L 
Sbjct: 1306 LESQLQDTQ--ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363

Query: 443  SKLADLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVH--LEGKIEQA 500
            +++AD++++ + DS      A++V   LQ    K    ++     K A +  LE    + 
Sbjct: 1364 AQVADMKKKME-DSVGCLETAEEVKRKLQ----KDLEGLSQRHEEKVAAYDKLEKTKTRL 1418

Query: 501  QRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAA 560
            Q+ +D+  VD     Q+A                     +L  K  + DQL A+   ++A
Sbjct: 1419 QQELDDLLVDLDHQRQSAC--------------------NLEKKQKKFDQLLAEEKTISA 1458

Query: 561  RGEGESPQARALASQLQDSLKDLKARMQEAMTQE 594
            +   E  +A A A + +     L   ++EAM Q+
Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 120/545 (22%), Positives = 210/545 (38%), Gaps = 107/545 (19%)

Query: 149  EVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISA 208
            EV++ +E  V Y +N   G+ + A    +  Q L HQ                      A
Sbjct: 3497 EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQ-LLHQAE-------------------VA 3536

Query: 209  MKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDED----AWASKDTE 264
             + F+  K   N G    ++N+   + +    + E+    QL   D++        +DT+
Sbjct: 3537 QQEFLEVKQRVNSGCV-MMENKLEGIGQFHCRVREMFS--QLADLDDELDGMGAIGRDTD 3593

Query: 265  AMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGT 324
            +++  +  +   LN+      D  AS     E   R +L+E G +          ++LG 
Sbjct: 3594 SLQSQIEDVRLFLNKIHVLKLDIEAS-----EAECRHMLEEEGTL----------DLLGL 3638

Query: 325  CKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSI 384
             + L  +  Q   L  RG         KA+Q  + L++   +VE+  RKL+ + N   + 
Sbjct: 3639 KRELEALNKQCGKLTERG---------KARQ--EQLELTLGRVEDFYRKLKGL-NDATTA 3686

Query: 385  AKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERD-DILRSLGEISALTS 443
            A++ +A Q W+     G E  E I   LA+ +   +   DP +     +  LG+   + S
Sbjct: 3687 AEEAEALQ-WVV----GTE-VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ-GLIQS 3739

Query: 444  KLADLRRQG-KGDSPEARA----LAKQVATALQNLQ--------------------TKTN 478
               D   QG + D  E  A    L K+VA  +  LQ                      T 
Sbjct: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799

Query: 479  RAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYR 538
              +AN +P  A   +     Q Q+ +    +DDR   +A +  L AEG R+A        
Sbjct: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQR-LLDDR---KATVDMLQAEGGRIAQ------- 3848

Query: 539  QDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDV 598
                A+    +++T QL  L +R      +A A   QL+D L  + A+      + +SD 
Sbjct: 3849 ---SAELADREKITGQLESLESRWTELLSKAAARQKQLEDIL--VLAKQFHETAEPISDF 3903

Query: 599  FSDTTTPIKLLAVAATAPPDAPNREEVFDERA--ANFENHSGKLGATAEKAAAVGTANKS 656
             S   T  KL          A  ++++   +A   + ENH+  +    +   ++ +    
Sbjct: 3904 LS--VTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSP 3961

Query: 657  TVEGI 661
              +G+
Sbjct: 3962 AEQGV 3966



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 53/245 (21%), Positives = 99/245 (40%), Gaps = 51/245 (20%)

Query: 354  QQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADP-----NGGPEGEEQ- 407
            ++++   + L  KV     +L+            ++   +WLAD      N  P   E  
Sbjct: 3754 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3813

Query: 408  -IRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRR-QGKGDSPEAR----- 460
             ++  + E + +  L DD K   D+L++ G   A +++LAD  +  G+ +S E+R     
Sbjct: 3814 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELL 3873

Query: 461  --------------ALAKQ---VATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQ---- 499
                           LAKQ    A  + +  + T + +ANS P         KI+Q    
Sbjct: 3874 SKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQT---AKIQQQIIR 3930

Query: 500  ---AQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLA 556
                +  I+N   D        +   V  G  L++ +  P  Q +L+  +++D L A+ +
Sbjct: 3931 HKALEEDIENHATD--------VHQAVKIGQSLSS-LTSPAEQGVLS--EKIDSLQARYS 3979

Query: 557  DLAAR 561
            ++  R
Sbjct: 3980 EIQDR 3984



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 80/400 (20%), Positives = 153/400 (38%), Gaps = 79/400 (19%)

Query: 18   QQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPA 77
            +Q+  ++++ ++     + I D    ++  +  ++N   VG +T +  +  I  + +   
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDF---LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEE- 3936

Query: 78   FIKVENACTKLVQAAQMLQS-DPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIR 136
               +EN  T + QA ++ QS    + PA        +G+LS   D L    +A   +I  
Sbjct: 3937 --DIENHATDVHQAVKIGQSLSSLTSPAE-------QGVLSEKIDSL----QARYSEIQD 3983

Query: 137  VC--KGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKM-IDERQQELTHQEHRVMLVN 193
             C  K  L    ++      ED V     L     K++ + + + +Q++ H++H   L  
Sbjct: 3984 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 4043

Query: 194  SMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE----INEIIRVLQ 249
            +   V                   ++ + +++A+KN    +++ + E    I E +  ++
Sbjct: 4044 NEEIV-------------------NRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIK 4084

Query: 250  LTSWDEDAWASKDTEAMKRA---LASIDSKLNQAKGWLRD------PSASPGDAGEQAI- 299
                D    +SK    +++A        S   +  GWLR+       S      GEQ   
Sbjct: 4085 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQ 4144

Query: 300  ---------------RQILDEAGKVG----ELCAGKERREILGTCKMLGQMTDQ---VAD 337
                           R +LD   +V     EL   + R    G  K++    +Q   V+D
Sbjct: 4145 FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVSD 4201

Query: 338  LRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAM 377
               +       A+Q++QQ  Q  D   A V    RKL A+
Sbjct: 4202 TIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 4241


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 120/545 (22%), Positives = 210/545 (38%), Gaps = 107/545 (19%)

Query: 149  EVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISA 208
            EV++ +E  V Y +N   G+ + A    +  Q L HQ                      A
Sbjct: 2995 EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQ-LLHQAE-------------------VA 3034

Query: 209  MKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDED----AWASKDTE 264
             + F+  K   N G    ++N+   + +    + E+    QL   D++        +DT+
Sbjct: 3035 QQEFLEVKQRVNSGCV-MMENKLEGIGQFHCRVREMFS--QLADLDDELDGMGAIGRDTD 3091

Query: 265  AMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGT 324
            +++  +  +   LN+      D  AS     E   R +L+E G +          ++LG 
Sbjct: 3092 SLQSQIEDVRLFLNKIHVLKLDIEAS-----EAECRHMLEEEGTL----------DLLGL 3136

Query: 325  CKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSI 384
             + L  +  Q   L  RG         KA+Q  + L++   +VE+  RKL+ + N   + 
Sbjct: 3137 KRELEALNKQCGKLTERG---------KARQ--EQLELTLGRVEDFYRKLKGL-NDATTA 3184

Query: 385  AKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERD-DILRSLGEISALTS 443
            A++ +A Q W+     G E  E I   LA+ +   +   DP +     +  LG+   + S
Sbjct: 3185 AEEAEALQ-WVV----GTE-VEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQ-GLIQS 3237

Query: 444  KLADLRRQG-KGDSPEARA----LAKQVATALQNLQ--------------------TKTN 478
               D   QG + D  E  A    L K+VA  +  LQ                      T 
Sbjct: 3238 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3297

Query: 479  RAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYR 538
              +AN +P  A   +     Q Q+ +    +DDR   +A +  L AEG R+A        
Sbjct: 3298 ELIANQKPPSAEYKVVKAQIQEQKLLQR-LLDDR---KATVDMLQAEGGRIAQ------- 3346

Query: 539  QDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQEAMTQEVSDV 598
                A+    +++T QL  L +R      +A A   QL+D L  + A+      + +SD 
Sbjct: 3347 ---SAELADREKITGQLESLESRWTELLSKAAARQKQLEDIL--VLAKQFHETAEPISDF 3401

Query: 599  FSDTTTPIKLLAVAATAPPDAPNREEVFDERA--ANFENHSGKLGATAEKAAAVGTANKS 656
             S   T  KL          A  ++++   +A   + ENH+  +    +   ++ +    
Sbjct: 3402 LS--VTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSP 3459

Query: 657  TVEGI 661
              +G+
Sbjct: 3460 AEQGV 3464



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 53/245 (21%), Positives = 99/245 (40%), Gaps = 51/245 (20%)

Query: 354  QQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADP-----NGGPEGEEQ- 407
            ++++   + L  KV     +L+            ++   +WLAD      N  P   E  
Sbjct: 3252 EEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYK 3311

Query: 408  -IRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRR-QGKGDSPEAR----- 460
             ++  + E + +  L DD K   D+L++ G   A +++LAD  +  G+ +S E+R     
Sbjct: 3312 VVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELL 3371

Query: 461  --------------ALAKQ---VATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQ---- 499
                           LAKQ    A  + +  + T + +ANS P         KI+Q    
Sbjct: 3372 SKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQT---AKIQQQIIR 3428

Query: 500  ---AQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLA 556
                +  I+N   D        +   V  G  L++ +  P  Q +L+  +++D L A+ +
Sbjct: 3429 HKALEEDIENHATD--------VHQAVKIGQSLSS-LTSPAEQGVLS--EKIDSLQARYS 3477

Query: 557  DLAAR 561
            ++  R
Sbjct: 3478 EIQDR 3482



 Score = 32.3 bits (72), Expect = 2.6
 Identities = 80/400 (20%), Positives = 153/400 (38%), Gaps = 79/400 (19%)

Query: 18   QQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPA 77
            +Q+  ++++ ++     + I D    ++  +  ++N   VG +T +  +  I  + +   
Sbjct: 3379 KQLEDILVLAKQFHETAEPISDF---LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEE- 3434

Query: 78   FIKVENACTKLVQAAQMLQS-DPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIR 136
               +EN  T + QA ++ QS    + PA        +G+LS   D L    +A   +I  
Sbjct: 3435 --DIENHATDVHQAVKIGQSLSSLTSPAE-------QGVLSEKIDSL----QARYSEIQD 3481

Query: 137  VC--KGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKM-IDERQQELTHQEHRVMLVN 193
             C  K  L    ++      ED V     L     K++ + + + +Q++ H++H   L  
Sbjct: 3482 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 3541

Query: 194  SMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAE----INEIIRVLQ 249
            +   V                   ++ + +++A+KN    +++ + E    I E +  ++
Sbjct: 3542 NEEIV-------------------NRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIK 3582

Query: 250  LTSWDEDAWASKDTEAMKRA---LASIDSKLNQAKGWLRD------PSASPGDAGEQAI- 299
                D    +SK    +++A        S   +  GWLR+       S      GEQ   
Sbjct: 3583 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQ 3642

Query: 300  ---------------RQILDEAGKVG----ELCAGKERREILGTCKMLGQMTDQ---VAD 337
                           R +LD   +V     EL   + R    G  K++    +Q   V+D
Sbjct: 3643 FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVSD 3699

Query: 338  LRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAM 377
               +       A+Q++QQ  Q  D   A V    RKL A+
Sbjct: 3700 TIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMAL 3739


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 107/624 (17%), Positives = 244/624 (39%), Gaps = 89/624 (14%)

Query: 56   RVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGI 115
            ++ + T +  E++ +  ++     K+E+ C++L +    L+     V    +  +     
Sbjct: 921  KIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--- 977

Query: 116  LSGTSDLLLTFDEAEVRKIIRVCKGILE-YLTVAEVVETMEDLVTYTKNLGPGMTKMAKM 174
            +   ++ +   DE  + K+ +  K + E +    + ++  ED V     L    TK+ + 
Sbjct: 978  VKNLTEEMAGLDET-IAKLSKEKKALQETHQQTLDDLQAEEDKVNI---LTKAKTKLEQQ 1033

Query: 175  IDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTV 234
            +D+ +  L  ++ + + ++     ++L   L  A +  +  +N K Q ++E L+ + F +
Sbjct: 1034 VDDLEGSL--EQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ-LDEKLEKKEFEI 1090

Query: 235  --------EKMSAEINEIIRVLQLTSWDED------------AWASKDTEAMKRALASID 274
                    ++ + EI    ++ +L +  E+            A A K    + R L  I 
Sbjct: 1091 SNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEIS 1150

Query: 275  SKLNQAKGWLRDPSA--SPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMT 332
             +L +A G            +A  Q +R+ L+EA    E      R++   +   LG+  
Sbjct: 1151 ERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQI 1210

Query: 333  DQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQ 392
            D +  ++              Q++ +    L  + ++ +   EA++ +K ++ K   + +
Sbjct: 1211 DNLQRVK--------------QKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLE 1256

Query: 393  NWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQG 452
            + +++     E ++++   L   R   +      E  +  R L E  AL S+L       
Sbjct: 1257 DQVSELKTKEEEQQRLINDLTAQRARLQ-----TEAGEYSRQLDEKDALVSQL------- 1304

Query: 453  KGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVH----LEGKIEQAQRWIDNPT 508
               S   +A  +Q+      L+ +T    A +   +++ H    L  + E+ Q       
Sbjct: 1305 ---SRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQE------ 1355

Query: 509  VDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQ 568
                  G+A ++  +++ +         Y  D + + + +++   +LA      E     
Sbjct: 1356 ------GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEA 1409

Query: 569  ARALASQLQDSLKDLKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDE 628
              A  +    SL+  K R+Q     EV D+  D     +  A  A       N ++V  E
Sbjct: 1410 VNAKCA----SLEKTKQRLQ----NEVEDLMLDVE---RSNAACAALDKKQRNFDKVLSE 1458

Query: 629  RAANFENHSGKLGATAEKAAAVGT 652
                +E    +L A+ +++ ++ T
Sbjct: 1459 WKQKYEETQAELEASQKESRSLST 1482



 Score = 38.5 bits (88), Expect = 0.037
 Identities = 68/300 (22%), Positives = 129/300 (43%), Gaps = 35/300 (11%)

Query: 308  KVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKV 367
            K+  L    E  + + T K   Q T    D  A+ +       +K   + +  + L  +V
Sbjct: 838  KIKPLLKSAETEKEMATMKEEFQKTK---DELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894

Query: 368  ENAARKL-EAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGAL-AEARKIAELCDD- 424
            ++ A  L +A    +Q I  KI      + +     E EE+I   L A+ RK+ + C + 
Sbjct: 895  QSEADSLADAEERCEQLIKNKIQLEAK-IKEVTERAEEEEEINAELTAKKRKLEDECSEL 953

Query: 425  PKERDDILRSLGEISA-----------LTSKLADLRRQGKGDSPEARALAKQVATALQNL 473
             K+ DD+  +L ++             LT ++A L       S E +AL +     L +L
Sbjct: 954  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL 1013

Query: 474  QTKTNRA----VANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRL 529
            Q + ++      A ++  +    LEG +EQ ++         R   + A R L  +  +L
Sbjct: 1014 QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKL--------RMDLERAKRKLEGD-LKL 1064

Query: 530  ANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKARMQE 589
            A         D     +++++   ++++L ++ E E    +A+  QLQ  +K+L+AR++E
Sbjct: 1065 AQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE----QAVEIQLQKKIKELQARIEE 1120


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.128    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,081,206
Number of Sequences: 37866
Number of extensions: 1985823
Number of successful extensions: 17742
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 505
Number of HSP's that attempted gapping in prelim test: 11688
Number of HSP's gapped (non-prelim): 3959
length of query: 1134
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1021
effective length of database: 13,968,660
effective search space: 14262001860
effective search space used: 14262001860
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.