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Search of human proteins with 7662402
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo
sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo s... 1052 0.0
gi|31317209 BTB/POZ domain containing protein 3 isoform b [Homo ... 933 0.0
gi|225543407 BTB domain protein BDPL [Homo sapiens] 700 0.0
gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens] 385 e-107
gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo sapiens] 366 e-101
gi|59814146 BTB (POZ) domain containing 1 isoform 2 [Homo sapiens] 278 1e-74
gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens] 101 2e-21
gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens] 101 2e-21
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 82 2e-15
gi|211904190 hypothetical protein LOC149478 [Homo sapiens] 80 5e-15
gi|151108435 BTB (POZ) domain containing 9 isoform b [Homo sapiens] 80 5e-15
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 73 6e-13
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 73 6e-13
gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo... 72 9e-13
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 72 2e-12
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 72 2e-12
gi|34101268 kelch-like 8 [Homo sapiens] 72 2e-12
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 70 4e-12
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 70 5e-12
gi|148664209 kelch-like 10 [Homo sapiens] 69 8e-12
gi|166235129 kelch-like 3 [Homo sapiens] 68 2e-11
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 67 3e-11
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 67 3e-11
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 67 5e-11
gi|194097389 kelch-like 38 [Homo sapiens] 66 7e-11
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 66 9e-11
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 66 9e-11
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 65 1e-10
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 65 1e-10
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 64 3e-10
>gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo
sapiens]
Length = 522
Score = 1052 bits (2720), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MVDDKEKNMKCLTFFLMLPETVKNRSKKSSKKANTSSSSSNSSKLPPVCYEIITLKTKKK 60
MVDDKEKNMKCLTFFLMLPETVKNRSKKSSKKANTSSSSSNSSKLPPVCYEIITLKTKKK
Sbjct: 1 MVDDKEKNMKCLTFFLMLPETVKNRSKKSSKKANTSSSSSNSSKLPPVCYEIITLKTKKK 60
Query: 61 KMAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAMMFNNDLMA 120
KMAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAMMFNNDLMA
Sbjct: 61 KMAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAMMFNNDLMA 120
Query: 121 DVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKY 180
DVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKY
Sbjct: 121 DVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKY 180
Query: 181 IYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDL 240
IYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDL
Sbjct: 181 IYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDL 240
Query: 241 TQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQ 300
TQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQ
Sbjct: 241 TQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQ 300
Query: 301 DLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAAKKPEL 360
DLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAAKKPEL
Sbjct: 301 DLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAAKKPEL 360
Query: 361 QFVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSA 420
QFVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSA
Sbjct: 361 QFVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSA 420
Query: 421 EYSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSY 480
EYSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSY
Sbjct: 421 EYSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSY 480
Query: 481 FGQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA 522
FGQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA
Sbjct: 481 FGQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA 522
>gi|31317209 BTB/POZ domain containing protein 3 isoform b [Homo
sapiens]
Length = 461
Score = 933 bits (2412), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 62 MAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAMMFNNDLMAD 121
MAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAMMFNNDLMAD
Sbjct: 1 MAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAMMFNNDLMAD 60
Query: 122 VHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYI 181
VHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYI
Sbjct: 61 VHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYI 120
Query: 182 YCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLT 241
YCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLT
Sbjct: 121 YCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLT 180
Query: 242 QRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQD 301
QRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQD
Sbjct: 181 QRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQRQD 240
Query: 302 LALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAAKKPELQ 361
LALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAAKKPELQ
Sbjct: 241 LALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAAKKPELQ 300
Query: 362 FVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAE 421
FVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAE
Sbjct: 301 FVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAE 360
Query: 422 YSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYF 481
YSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYF
Sbjct: 361 YSAKIELKRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYF 420
Query: 482 GQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA 522
GQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA
Sbjct: 421 GQEGMTEVQCGKVTVQFQCSSDSTNGTGVQGGQIPELIFYA 461
>gi|225543407 BTB domain protein BDPL [Homo sapiens]
Length = 485
Score = 700 bits (1806), Expect = 0.0
Identities = 342/432 (79%), Positives = 375/432 (86%)
Query: 91 NNLIPAPNWQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFH 150
NN +P W+ PT+RERNA+MFNN+LMADVHFVVGPPG T+ +P HKYVLAVGSSVF+
Sbjct: 54 NNHQESPGWRCCRPTLRERNALMFNNELMADVHFVVGPPGATRTVPAHKYVLAVGSSVFY 113
Query: 151 AMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLAR 210
AMFYG+LAE K EI IPDVEPAAFL +LKY+Y DEIDL ADTVLATLYAAKKYIVP LA+
Sbjct: 114 AMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAK 173
Query: 211 ACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLE 270
ACVNFLETSL AKNACVLLSQS LFEEP+LTQRCWEVIDAQAE+AL+SEGFC+ID QTLE
Sbjct: 174 ACVNFLETSLEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAEMALRSEGFCEIDRQTLE 233
Query: 271 SILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDF 330
I+ RE LN KE VVFEA LNWAE EC+RQ L ++ NKR VLG+ALYL+RIPTM L++F
Sbjct: 234 IIVTREALNTKEAVVFEAVLNWAEAECKRQGLPITPRNKRHVLGRALYLVRIPTMTLEEF 293
Query: 331 ANGAAQSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRCHRFQSCAYRSNQWRY 390
ANGAAQS +LTL ET+ IFLWYTA KP L F RKGL PQRCHRFQS AYRSNQWRY
Sbjct: 294 ANGAAQSDILTLEETHSIFLWYTATNKPRLDFPLTKRKGLAPQRCHRFQSSAYRSNQWRY 353
Query: 391 RGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIELKRQGVVLGQNLSKYFSDGSSNT 450
RGRCDSIQFAVD+RVFIAG GLYGSS G AEYS KIELKR GVVL QNL+K+ SDGSSNT
Sbjct: 354 RGRCDSIQFAVDRRVFIAGLGLYGSSSGKAEYSVKIELKRLGVVLAQNLTKFMSDGSSNT 413
Query: 451 FPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEVQCGKVTVQFQCSSDSTNGTGV 510
FPVWFE+PVQ+E DTFYTAS +LDG+ELSYFGQEGMTEVQCGKV QFQCSSDSTNGTGV
Sbjct: 414 FPVWFEHPVQVEQDTFYTASAVLDGSELSYFGQEGMTEVQCGKVAFQFQCSSDSTNGTGV 473
Query: 511 QGGQIPELIFYA 522
QGGQIPELIFYA
Sbjct: 474 QGGQIPELIFYA 485
>gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens]
Length = 525
Score = 385 bits (988), Expect = e-107
Identities = 202/436 (46%), Positives = 283/436 (64%), Gaps = 14/436 (3%)
Query: 96 APNWQGLYPTIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYG 155
A NWQ PT++ER A +FNN+++ DVHF+VG +QR+P H++VLAVGS+VF AMF G
Sbjct: 93 AYNWQASKPTVQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNG 152
Query: 156 ELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNF 215
+A EI +PDVEPAAFLA+LK++Y DE+ + +TV+ TLY AKKY VP L CV F
Sbjct: 153 GMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 212
Query: 216 LETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRR 275
L+ +L A NA +LL+Q+ LF+EP L C E ID A+ +EGF DID TL ++L R
Sbjct: 213 LKKNLRADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLER 272
Query: 276 ETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAA 335
+TL +E+ +F A + W+E ECQRQ L ++ EN+RKVLGKAL LIR P M +++FA G A
Sbjct: 273 DTLGIREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPA 332
Query: 336 QSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRC--HRFQSCAYRSNQWRYRGR 393
QSG+L E +FL +T KP ++F+ + R L + C +RFQ ++W Y G
Sbjct: 333 QSGILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQV---ESRWGYSGT 389
Query: 394 CDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIEL--KRQGVVLGQNLSKYFSDGSSNTF 451
D I+F+V+KR+F+ GFGLYGS G +Y I++ VLGQN + + DGS++TF
Sbjct: 390 SDRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTF 449
Query: 452 PVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEV------QCGKVTVQFQCSSDST 505
V F+ PV++ P+ YTA L G + S++G +G+ +V K F ++ +
Sbjct: 450 RVMFKEPVEVLPNVNYTACATLKGPD-SHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNN 508
Query: 506 NGTGVQGGQIPELIFY 521
NGT V+ GQIPE+IFY
Sbjct: 509 NGTSVEDGQIPEVIFY 524
>gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo sapiens]
Length = 482
Score = 366 bits (939), Expect = e-101
Identities = 197/444 (44%), Positives = 280/444 (63%), Gaps = 23/444 (5%)
Query: 95 PAPNWQGLYPTIRERNAMMFNNDLMADVHFVVGP------PGGTQRLPGHKYVLAVGSSV 148
P NWQ +++ER A +FN++L++DV FV+G GG QR+P H++VLA GS+V
Sbjct: 44 PLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAV 103
Query: 149 FHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHL 208
F AMF G +A EI +PDVEPAAFLA+L+++Y DE+ + +TV+ TLY AKKY VP L
Sbjct: 104 FDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPAL 163
Query: 209 ARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQT 268
CV FL L A NA +LL+Q+ LF+EP L C + ID A+ +EGF DID T
Sbjct: 164 EAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDT 223
Query: 269 LESILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALD 328
L ++L R+TL+ +E +F A + WAE ECQRQ L ++ NK+KVLGKAL LIR P M ++
Sbjct: 224 LCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIE 283
Query: 329 DFANGAAQSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRC--HRFQSCAYRSN 386
+FA G AQSG+L+ E ++FL +T KP ++++ + R L + C +RFQ +
Sbjct: 284 EFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQV---ES 340
Query: 387 QWRYRGRCDSIQFAVDKRVFIAGFGLYGSSCGSAEYSAKIEL----KRQGVVLGQNLSKY 442
+W Y G D I+F V++R+ I GFGLYGS G +Y I++ K+Q LGQN + +
Sbjct: 341 RWGYSGTSDRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKKQ--TLGQNDTGF 398
Query: 443 FSDGSSNTFPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEV-----QCGKVTVQ 497
DG++NTF V F+ P++I P+ YTA L G + S++G +G+ +V K
Sbjct: 399 SCDGTANTFRVMFKEPIEILPNVCYTACATLKGPD-SHYGTKGLKKVVHETPAASKTVFF 457
Query: 498 FQCSSDSTNGTGVQGGQIPELIFY 521
F S + NGT ++ GQIPE+IFY
Sbjct: 458 FFSSPGNNNGTSIEDGQIPEIIFY 481
>gi|59814146 BTB (POZ) domain containing 1 isoform 2 [Homo sapiens]
Length = 385
Score = 278 bits (710), Expect = 1e-74
Identities = 144/312 (46%), Positives = 202/312 (64%), Gaps = 11/312 (3%)
Query: 95 PAPNWQGLYPTIRERNAMMFNNDLMADVHFVVGP------PGGTQRLPGHKYVLAVGSSV 148
P NWQ +++ER A +FN++L++DV FV+G GG QR+P H++VLA GS+V
Sbjct: 44 PLYNWQATKASLKERFAFLFNSELLSDVRFVLGKGRGAAAAGGPQRIPAHRFVLAAGSAV 103
Query: 149 FHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHL 208
F AMF G +A EI +PDVEPAAFLA+L+++Y DE+ + +TV+ TLY AKKY VP L
Sbjct: 104 FDAMFNGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPAL 163
Query: 209 ARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQT 268
CV FL L A NA +LL+Q+ LF+EP L C + ID A+ +EGF DID T
Sbjct: 164 EAHCVEFLTKHLRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDIDT 223
Query: 269 LESILRRETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALD 328
L ++L R+TL+ +E +F A + WAE ECQRQ L ++ NK+KVLGKAL LIR P M ++
Sbjct: 224 LCAVLERDTLSIRESRLFGAVVRWAEAECQRQQLPVTFGNKQKVLGKALSLIRFPLMTIE 283
Query: 329 DFANGAAQSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQRC--HRFQSCAYRSN 386
+FA G AQSG+L+ E ++FL +T KP ++++ + R L + C +RFQ +
Sbjct: 284 EFAAGPAQSGILSDREVVNLFLHFTVNPKPRVEYIDRPRCCLRGKECCINRFQQV---ES 340
Query: 387 QWRYRGRCDSIQ 398
+W Y G D I+
Sbjct: 341 RWGYSGTSDRIR 352
>gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
Length = 612
Score = 101 bits (251), Expect = 2e-21
Identities = 75/258 (29%), Positives = 118/258 (45%), Gaps = 25/258 (9%)
Query: 121 DVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIP--DVEPAAFLAML 178
DV FVV +R P H+ +LA F A+ YG + E + E IP D AF +L
Sbjct: 37 DVTFVVEK----KRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLL 92
Query: 179 KYIYCDEIDLA---ADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLF 235
KYIY L + +L L A KY P L + +L T L+ +N C+ + L+
Sbjct: 93 KYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLY 152
Query: 236 EEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEV 295
P LT C +D A+ L SEGF + L +I+ R++ A E +F A LNW +
Sbjct: 153 SLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCK- 211
Query: 296 ECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAA 355
N ++ + + +R+P M+L + N SG+L+ + D + +
Sbjct: 212 -----------HNSKENHAEIMQAVRLPLMSLTELLNVVRPSGLLSPDAILDAIKVRSES 260
Query: 356 KKPELQFVSKARKGLVPQ 373
+ +L + R L+P+
Sbjct: 261 RDMDLNY----RGMLIPE 274
>gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
Length = 612
Score = 101 bits (251), Expect = 2e-21
Identities = 75/258 (29%), Positives = 118/258 (45%), Gaps = 25/258 (9%)
Query: 121 DVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIP--DVEPAAFLAML 178
DV FVV +R P H+ +LA F A+ YG + E + E IP D AF +L
Sbjct: 37 DVTFVVEK----KRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLL 92
Query: 179 KYIYCDEIDLA---ADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLF 235
KYIY L + +L L A KY P L + +L T L+ +N C+ + L+
Sbjct: 93 KYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLY 152
Query: 236 EEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEV 295
P LT C +D A+ L SEGF + L +I+ R++ A E +F A LNW +
Sbjct: 153 SLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCK- 211
Query: 296 ECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLWYTAA 355
N ++ + + +R+P M+L + N SG+L+ + D + +
Sbjct: 212 -----------HNSKENHAEIMQAVRLPLMSLTELLNVVRPSGLLSPDAILDAIKVRSES 260
Query: 356 KKPELQFVSKARKGLVPQ 373
+ +L + R L+P+
Sbjct: 261 RDMDLNY----RGMLIPE 274
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 81.6 bits (200), Expect = 2e-15
Identities = 58/215 (26%), Positives = 95/215 (44%), Gaps = 11/215 (5%)
Query: 131 GTQRLPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEIDLA 189
G + LP H+ +L+ S F F E+ E K E+ + +V+PA ++KY+Y IDL
Sbjct: 40 GDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLN 99
Query: 190 ADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVID 249
V A ++ +P + CV++L+ L+ N +L L + P L E +
Sbjct: 100 DGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVS 159
Query: 250 AQAELALKSEGFCDIDFQTLESILRRETLNA-KEIVVFEAALNWAEVECQRQDLALSIEN 308
+ K E F + Q L S++ ++LN KE VFEA + W + EN
Sbjct: 160 DRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTD---------KEN 210
Query: 309 KRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLN 343
+ K L + IR M F + + ++ N
Sbjct: 211 RVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSN 245
>gi|211904190 hypothetical protein LOC149478 [Homo sapiens]
Length = 291
Score = 80.1 bits (196), Expect = 5e-15
Identities = 67/274 (24%), Positives = 119/274 (43%), Gaps = 6/274 (2%)
Query: 113 MFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAED-KDEIRIPDVEP 171
+ NN +DV FVVG Q + H+ +LA + F + E + + V
Sbjct: 22 LVNNPRYSDVCFVVGQE--RQEVFAHRCLLACRCNFFQRLLGTEPGPGVPSPVVLSTVPT 79
Query: 172 AAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQ 231
AFLA+L+++Y + + L +VL L AA +Y + L C+ F+ L C L
Sbjct: 80 EAFLAVLEFLYTNSVKLYRHSVLEVLTAAVEYGLEELRELCLQFVVKVLDVDLVCEALQV 139
Query: 232 SCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALN 291
+ F L +RC I+A ++ AL++ GF ++ L +LR + L E + AA +
Sbjct: 140 AVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVDEAELVRAARS 199
Query: 292 WAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFLW 351
WA V L + + K L L + L Q ++ + + + +
Sbjct: 200 WARVGA--AVLERPVAEVAAPVVKELRLALLAPAELSALEEQNRQEPLIPVEQIVEAWKC 257
Query: 352 YTAAKKPELQFV-SKARKGLVPQRCHRFQSCAYR 384
+ + E + + R+G +P+ HRF +++
Sbjct: 258 HALRRGDEARGAPCRRRRGTLPREHHRFLDLSFK 291
>gi|151108435 BTB (POZ) domain containing 9 isoform b [Homo sapiens]
Length = 544
Score = 80.1 bits (196), Expect = 5e-15
Identities = 59/219 (26%), Positives = 100/219 (45%), Gaps = 19/219 (8%)
Query: 158 AEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLA---ADTVLATLYAAKKYIVPHLARACVN 214
++ + EI + D AF +LKYIY L + +L L A KY P L +
Sbjct: 4 SQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSE 63
Query: 215 FLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILR 274
+L T L+ +N C+ + L+ P LT C +D A+ L SEGF + L +I+
Sbjct: 64 YLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVL 123
Query: 275 RETLNAKEIVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGA 334
R++ A E +F A LNW + N ++ + + +R+P M+L + N
Sbjct: 124 RDSFAAPEKDIFLALLNWCK------------HNSKENHAEIMQAVRLPLMSLTELLNVV 171
Query: 335 AQSGVLTLNETNDIFLWYTAAKKPELQFVSKARKGLVPQ 373
SG+L+ + D + ++ +L + R L+P+
Sbjct: 172 RPSGLLSPDAILDAIKVRSESRDMDLNY----RGMLIPE 206
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 73.2 bits (178), Expect = 6e-13
Identities = 46/177 (25%), Positives = 88/177 (49%), Gaps = 3/177 (1%)
Query: 133 QRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAAD 191
+++P H+ VLA S F+ MF + E K E+ + D EP ++++ Y I + ++
Sbjct: 53 RKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN 112
Query: 192 TVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQ 251
V + L AA +Y + + + CV+FL+ + A N + + + P+L + I
Sbjct: 113 NVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQH 172
Query: 252 AELALKSEGFCDIDFQTLESILRRETLNAK-EIVVFEAALNWAEV-ECQRQDLALSI 306
K++ F +D + + +L ++TL + E V++AA+ W + E RQ + I
Sbjct: 173 FTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDI 229
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 73.2 bits (178), Expect = 6e-13
Identities = 46/177 (25%), Positives = 88/177 (49%), Gaps = 3/177 (1%)
Query: 133 QRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAAD 191
+++P H+ VLA S F+ MF + E K E+ + D EP ++++ Y I + ++
Sbjct: 31 RKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN 90
Query: 192 TVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQ 251
V + L AA +Y + + + CV+FL+ + A N + + + P+L + I
Sbjct: 91 NVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQH 150
Query: 252 AELALKSEGFCDIDFQTLESILRRETLNAK-EIVVFEAALNWAEV-ECQRQDLALSI 306
K++ F +D + + +L ++TL + E V++AA+ W + E RQ + I
Sbjct: 151 FTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDI 207
>gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo
sapiens]
Length = 621
Score = 72.4 bits (176), Expect = 9e-13
Identities = 52/176 (29%), Positives = 77/176 (43%), Gaps = 7/176 (3%)
Query: 131 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAA 190
G + P H+ VLA S F A F E E E+ + +V P +L Y+Y EI L
Sbjct: 40 GEREFPCHRLVLAACSPYFRARFLAE-PERAGELHLEEVSPDVVAQVLHYLYTSEIALDE 98
Query: 191 DTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDA 250
+V AA ++ +P + CV+FL+ L N + L + L + I A
Sbjct: 99 ASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICA 158
Query: 251 QAELALKSEGFCDIDFQTLESILRRETLNA-KEIVVFEAALNW-----AEVECQRQ 300
L + F + L +I+ + LN KE VFEA + W AE + +RQ
Sbjct: 159 HFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQ 214
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 71.6 bits (174), Expect = 2e-12
Identities = 49/165 (29%), Positives = 77/165 (46%), Gaps = 2/165 (1%)
Query: 138 HKYVLAVGSSVFHAMFYGELAEDKDEI-RIPDVEPAAFLAMLKYIYCDEIDLAADTVLAT 196
HK VLA S VF AMF L E E+ I + P ++++ Y I + VL
Sbjct: 96 HKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHV 155
Query: 197 LYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELAL 256
+ A Y + + RAC +FL L NA + + + +L QR E I
Sbjct: 156 MNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVA 215
Query: 257 KSEGFCDIDFQTLESILRRETLNAK-EIVVFEAALNWAEVECQRQ 300
K E F ++ L +++ R+ LN + E VF A +NW + +C+++
Sbjct: 216 KQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQR 260
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 71.6 bits (174), Expect = 2e-12
Identities = 49/165 (29%), Positives = 77/165 (46%), Gaps = 2/165 (1%)
Query: 138 HKYVLAVGSSVFHAMFYGELAEDKDEI-RIPDVEPAAFLAMLKYIYCDEIDLAADTVLAT 196
HK VLA S VF AMF L E E+ I + P ++++ Y I + VL
Sbjct: 96 HKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHV 155
Query: 197 LYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELAL 256
+ A Y + + RAC +FL L NA + + + +L QR E I
Sbjct: 156 MNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVA 215
Query: 257 KSEGFCDIDFQTLESILRRETLNAK-EIVVFEAALNWAEVECQRQ 300
K E F ++ L +++ R+ LN + E VF A +NW + +C+++
Sbjct: 216 KQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQR 260
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 71.6 bits (174), Expect = 2e-12
Identities = 72/294 (24%), Positives = 119/294 (40%), Gaps = 27/294 (9%)
Query: 62 MAADIFPRKKPANSSSTSVQQYHQQNLSNNNLIPAPNWQGLYPTIRERNAM--------- 112
MA+D K+ N + +Q Q + N + I + + + I E N
Sbjct: 1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSF--IFEANEAWKDFHGSLL 58
Query: 113 -MFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDE-IRIPDVE 170
+ N + DV VG ++ + HK VLA F AMF E+AE K I I D +
Sbjct: 59 RFYENGELCDVTLKVG----SKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFD 114
Query: 171 PAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLS 230
A ++K++Y + L D V LYAA V +ARAC +++ N + +
Sbjct: 115 GDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRA 174
Query: 231 QSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAK-EIVVFEAA 289
+ DL + ++ E F + Q L +L LN + E V+ AA
Sbjct: 175 FAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAA 234
Query: 290 LNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMALDDFANGAAQSGVLTLN 343
+ W L + ++ K L + L +R+P + +D A+ ++ N
Sbjct: 235 IKW---------LLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQN 279
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 70.5 bits (171), Expect = 4e-12
Identities = 60/224 (26%), Positives = 99/224 (44%), Gaps = 15/224 (6%)
Query: 105 TIRERNAMMFNNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-E 163
++ E+ + + L D+ +V GT+ P HK VLA SS F AMF L+E K
Sbjct: 16 SLLEQLKLFYEQQLFTDIVLIVE---GTE-FPCHKMVLATCSSYFRAMFMSGLSESKQTH 71
Query: 164 IRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAK 223
+ + +V+ A ++ Y Y + + TV A V + + C +L ++A+
Sbjct: 72 VHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 131
Query: 224 NACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNA-KE 282
N LLS + LF +L Q +++ + + F + L IL + LN KE
Sbjct: 132 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKE 191
Query: 283 IVVFEAALNWAEVECQRQDLALSIENKRKVLGKALYLIRIPTMA 326
V EAA+ W E + E++ + L L IRI ++
Sbjct: 192 ETVREAAMLWLE---------YNTESRSQYLSSVLSQIRIDALS 226
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 70.1 bits (170), Expect = 5e-12
Identities = 52/199 (26%), Positives = 94/199 (47%), Gaps = 11/199 (5%)
Query: 131 GTQRLPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEIDLA 189
G ++ HK VLA S F AMF G L+E + E+ ++ A A+++Y Y + ++
Sbjct: 42 GDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFIS 101
Query: 190 ADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVID 249
DTV + L AA + + + C FLE+ L N + + + DL + I
Sbjct: 102 QDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYIC 161
Query: 250 AQAELALKSEGFCDIDFQTLESILRRETLN-AKEIVVFEAALNWAEVECQRQDLALSIEN 308
E ++E F ++ L+ I+ + LN A E VF A +W + + ++
Sbjct: 162 QNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYD---------VQE 212
Query: 309 KRKVLGKALYLIRIPTMAL 327
++K L + L +R+P +++
Sbjct: 213 RQKYLAQLLNSVRLPLLSV 231
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 69.3 bits (168), Expect = 8e-12
Identities = 54/211 (25%), Positives = 97/211 (45%), Gaps = 7/211 (3%)
Query: 138 HKYVLAVGSSVFHAMFY-GELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLAT 196
HK +L SS F A+F G +K IP + P +++Y Y + + D V
Sbjct: 53 HKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKL 112
Query: 197 LYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELAL 256
L AA ++ + + R C FL++ L N + + + P+L Q+ + I E +
Sbjct: 113 LAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMV 172
Query: 257 K-SEGFCDIDFQTLESILRRETLNAK-EIVVFEAALNWAEVECQ--RQDLALSIENKRKV 312
K S F ++ L+ I+ ++ LN K E VFEA L W + Q +Q +++ + R
Sbjct: 173 KVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLA 232
Query: 313 LGKALYLIRIPTMALDDFANGAAQSGVLTLN 343
L A Y + + ++D+ + + + +N
Sbjct: 233 LMHAEYFMN--NVKMNDYVKDSEECKPVIIN 261
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 67.8 bits (164), Expect = 2e-11
Identities = 53/218 (24%), Positives = 96/218 (44%), Gaps = 11/218 (5%)
Query: 135 LPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTV 193
+ H+ VLA S F AMF G+++E K +I I DV+ ++ YIY EI++ + V
Sbjct: 61 IEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENV 120
Query: 194 LATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAE 253
L AA + + + C +FL++ L N + + + + DL Q+ +
Sbjct: 121 QVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFP 180
Query: 254 LALKSEGFCDIDFQTLESILRRETLN-AKEIVVFEAALNWAEVECQRQDLALSIENKRKV 312
+ E F + + S++ + L + E VFEA ++W E E + +
Sbjct: 181 EVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYE---------KETRLEH 231
Query: 313 LGKALYLIRIPTMALDDFANGAAQSGVLTLNETNDIFL 350
+ K + +R+P + D + ++ N T FL
Sbjct: 232 MAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFL 269
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 67.4 bits (163), Expect = 3e-11
Identities = 53/211 (25%), Positives = 100/211 (47%), Gaps = 8/211 (3%)
Query: 115 NNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDE-IRIPDVEPAA 173
+ +L+ DV V + H+ VLA S FHAMF GE++E + + +RI +V+
Sbjct: 55 SQNLLCDVTIVAED----MEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWT 110
Query: 174 FLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSC 233
++ Y+Y EI + + V L AA + + + C FLE+ L N + + +
Sbjct: 111 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 170
Query: 234 LFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLN-AKEIVVFEAALNW 292
+ DL + + + SE F ++ + + S++ + L + E VFEA + W
Sbjct: 171 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 230
Query: 293 A--EVECQRQDLALSIENKRKVLGKALYLIR 321
+ + +++ +A +E+ R L YL++
Sbjct: 231 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQ 261
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 67.4 bits (163), Expect = 3e-11
Identities = 53/211 (25%), Positives = 100/211 (47%), Gaps = 8/211 (3%)
Query: 115 NNDLMADVHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDE-IRIPDVEPAA 173
+ +L+ DV V + H+ VLA S FHAMF GE++E + + +RI +V+
Sbjct: 51 SQNLLCDVTIVAED----MEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWT 106
Query: 174 FLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSC 233
++ Y+Y EI + + V L AA + + + C FLE+ L N + + +
Sbjct: 107 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 166
Query: 234 LFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLN-AKEIVVFEAALNW 292
+ DL + + + SE F ++ + + S++ + L + E VFEA + W
Sbjct: 167 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 226
Query: 293 A--EVECQRQDLALSIENKRKVLGKALYLIR 321
+ + +++ +A +E+ R L YL++
Sbjct: 227 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQ 257
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 66.6 bits (161), Expect = 5e-11
Identities = 63/262 (24%), Positives = 111/262 (42%), Gaps = 33/262 (12%)
Query: 69 RKKPANSSSTSVQQYHQQN-----LSNNNLIPAPNWQGLYPTIRERNAMMFNNDLMADVH 123
RK A+S S ++ +H+ + L++ NL+ R +F + L+
Sbjct: 9 RKSRASSGSINIYLFHKSSYADSVLTHLNLL--------------RQQRLFTDVLLH--- 51
Query: 124 FVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPD-VEPAAFLAMLKYI 181
G + P H+ VLA S F AMF G L E +D E+ + + P +L Y
Sbjct: 52 ------AGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYA 105
Query: 182 YCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLT 241
Y + + + + L A + AC FLE +L N +L S + L
Sbjct: 106 YSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLY 165
Query: 242 QRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAK-EIVVFEAALNWAEVECQRQ 300
+ W + + + K+E F + + +L E L + E +V+E+A+NW + +++
Sbjct: 166 ELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKR 225
Query: 301 DLALS--IENKRKVLGKALYLI 320
L ++ R L A+YL+
Sbjct: 226 YCYLPELLQTVRLALLPAIYLM 247
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 66.2 bits (160), Expect = 7e-11
Identities = 44/169 (26%), Positives = 76/169 (44%), Gaps = 1/169 (0%)
Query: 131 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLA 189
G + +P H+ VLA S F AMF E + ++++ ++P ++ Y+Y E +A
Sbjct: 41 GAREIPCHRNVLASSSPYFRAMFCSSFREKSEAKVQLKGIDPPTLDQIVSYVYTGEAHIA 100
Query: 190 ADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVID 249
D VL + AA P L AC ++L++ L+ N ++ S + L ++ EV
Sbjct: 101 TDNVLPVMEAASMLQFPKLFEACSSYLQSQLAPSNCLGMIRLSEILSCETLKKKAREVAL 160
Query: 250 AQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQ 298
S ++ L L + L +E VFEA + W + + Q
Sbjct: 161 TSFPEVAASADLKELCALELRDYLGDDGLCGEEEKVFEALMVWIKHDLQ 209
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 65.9 bits (159), Expect = 9e-11
Identities = 52/198 (26%), Positives = 88/198 (44%), Gaps = 11/198 (5%)
Query: 131 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLA 189
G +R+P H+ VL+ S F AMF ++ E + +EI++ VEP + ++++Y Y ++L
Sbjct: 181 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 240
Query: 190 ADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVID 249
D + L A + + AC FL L N + S + DL +
Sbjct: 241 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 300
Query: 250 AQAELALKSEGFCDIDFQTLESILRRETLN-AKEIVVFEAALNWAEVECQRQDLALSIEN 308
++++ F + + +L + +N E + A L W R DL E
Sbjct: 301 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWV-----RHDL----EQ 351
Query: 309 KRKVLGKALYLIRIPTMA 326
+RK L K L IR+P +A
Sbjct: 352 RRKDLSKLLAYIRLPLLA 369
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 65.9 bits (159), Expect = 9e-11
Identities = 52/198 (26%), Positives = 88/198 (44%), Gaps = 11/198 (5%)
Query: 131 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLA 189
G +R+P H+ VL+ S F AMF ++ E + +EI++ VEP + ++++Y Y ++L
Sbjct: 227 GDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 286
Query: 190 ADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVID 249
D + L A + + AC FL L N + S + DL +
Sbjct: 287 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTM 346
Query: 250 AQAELALKSEGFCDIDFQTLESILRRETLN-AKEIVVFEAALNWAEVECQRQDLALSIEN 308
++++ F + + +L + +N E + A L W R DL E
Sbjct: 347 EHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWV-----RHDL----EQ 397
Query: 309 KRKVLGKALYLIRIPTMA 326
+RK L K L IR+P +A
Sbjct: 398 RRKDLSKLLAYIRLPLLA 415
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 65.5 bits (158), Expect = 1e-10
Identities = 51/180 (28%), Positives = 81/180 (45%), Gaps = 4/180 (2%)
Query: 135 LPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTV 193
+P H+ VLA S F AMF + E D + I ++ A A L Y Y + + D V
Sbjct: 63 IPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNV 122
Query: 194 LATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAE 253
+ V L++AC +FL S++ N LLS S + L +
Sbjct: 123 EMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFS 182
Query: 254 LALKSEGFCDIDFQTLESILRRETLNA-KEIVVFEAALNWAE--VECQRQDLALSIENKR 310
L KS F +++F L+ L + LN +E +V + L+W + +E +++ L IE R
Sbjct: 183 LLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVR 242
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 65.5 bits (158), Expect = 1e-10
Identities = 51/180 (28%), Positives = 81/180 (45%), Gaps = 4/180 (2%)
Query: 135 LPGHKYVLAVGSSVFHAMFYGELAE-DKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTV 193
+P H+ VLA S F AMF + E D + I ++ A A L Y Y + + D V
Sbjct: 63 IPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNV 122
Query: 194 LATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAE 253
+ V L++AC +FL S++ N LLS S + L +
Sbjct: 123 EMFFQLSSFLQVSFLSKACSDFLIKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFS 182
Query: 254 LALKSEGFCDIDFQTLESILRRETLNA-KEIVVFEAALNWAE--VECQRQDLALSIENKR 310
L KS F +++F L+ L + LN +E +V + L+W + +E +++ L IE R
Sbjct: 183 LLFKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVR 242
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 64.3 bits (155), Expect = 3e-10
Identities = 52/204 (25%), Positives = 93/204 (45%), Gaps = 25/204 (12%)
Query: 131 GTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLA 189
G R+P H+ VL+ S F AMF ++ E K +E+R+ V+P A ++++Y Y + L
Sbjct: 189 GHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLK 248
Query: 190 ADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLLSQSCLFEEPDLTQRCWEVID 249
DT+ + L AA + + C NFL L N + S F + Q C E+++
Sbjct: 249 EDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRS----FGD---AQGCTELLN 301
Query: 250 AQAEL-------ALKSEGFCDIDFQTLESILRRETLNA-KEIVVFEAALNWAEVECQRQD 301
+ +K++ F + + +L + +N E +F A + W
Sbjct: 302 VAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQW--------- 352
Query: 302 LALSIENKRKVLGKALYLIRIPTM 325
+ ++N++ LG L IR+P +
Sbjct: 353 VGHDVQNRQGELGMLLSYIRLPLL 376
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,905,615
Number of Sequences: 37866
Number of extensions: 792243
Number of successful extensions: 2331
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 2126
Number of HSP's gapped (non-prelim): 166
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.