BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo sapiens] (623 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo... 1267 0.0 gi|206597556 kelch domain containing 7B [Homo sapiens] 313 4e-85 gi|116089333 kelch domain containing 7A [Homo sapiens] 287 2e-77 gi|55749726 kelch domain containing 5 [Homo sapiens] 125 9e-29 gi|55925604 kelch-like 18 [Homo sapiens] 110 5e-24 gi|55925608 kelch-like 21 [Homo sapiens] 104 2e-22 gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 96 1e-19 gi|24308181 kelch-like 9 [Homo sapiens] 93 6e-19 gi|40807500 kelch-like 20 [Homo sapiens] 93 8e-19 gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 91 3e-18 gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 91 3e-18 gi|45643138 kelch-like 13 [Homo sapiens] 89 2e-17 gi|38194229 kelch-like 17 [Homo sapiens] 88 3e-17 gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 86 1e-16 gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 86 1e-16 gi|157384932 hypothetical protein LOC390594 [Homo sapiens] 85 2e-16 gi|23397572 kelch-like 34 [Homo sapiens] 84 4e-16 gi|14780904 kelch-like 1 protein [Homo sapiens] 82 2e-15 gi|31542246 kelch-like 36 [Homo sapiens] 82 2e-15 gi|158508542 kelch-like 33 [Homo sapiens] 81 3e-15 gi|8922854 kelch-like 26 [Homo sapiens] 81 3e-15 gi|24432026 kelch-like [Homo sapiens] 80 6e-15 gi|156616301 kelch-like 32 [Homo sapiens] 80 7e-15 gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 79 1e-14 gi|40018614 DRE1 protein [Homo sapiens] 79 1e-14 gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 78 2e-14 gi|128485503 kelch-like 30 [Homo sapiens] 78 2e-14 gi|55741643 kelch-like 14 [Homo sapiens] 77 4e-14 gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 75 1e-13 gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 75 1e-13 >gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo sapiens] Length = 623 Score = 1267 bits (3278), Expect = 0.0 Identities = 623/623 (100%), Positives = 623/623 (100%) Query: 1 MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEG 60 MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEG Sbjct: 1 MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEG 60 Query: 61 AATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASP 120 AATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASP Sbjct: 61 AATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASP 120 Query: 121 EEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVS 180 EEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVS Sbjct: 121 EEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVS 180 Query: 181 LTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVL 240 LTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVL Sbjct: 181 LTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVL 240 Query: 241 SAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAA 300 SAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAA Sbjct: 241 SAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAA 300 Query: 301 LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY 360 LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY Sbjct: 301 LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY 360 Query: 361 LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE 420 LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE Sbjct: 361 LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE 420 Query: 421 CLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEW 480 CLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEW Sbjct: 421 CLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEW 480 Query: 481 QECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAP 540 QECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAP Sbjct: 481 QECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAP 540 Query: 541 LRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDV 600 LRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDV Sbjct: 541 LRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDV 600 Query: 601 RGVLIPFALSLPEKPPRGEQGAP 623 RGVLIPFALSLPEKPPRGEQGAP Sbjct: 601 RGVLIPFALSLPEKPPRGEQGAP 623 >gi|206597556 kelch domain containing 7B [Homo sapiens] Length = 594 Score = 313 bits (801), Expect = 4e-85 Identities = 227/620 (36%), Positives = 298/620 (48%), Gaps = 73/620 (11%) Query: 21 ESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEGAATSPPSSGGPRVVERQWEA 80 + +G+ A +G S S + P S G T G + R E Sbjct: 11 QDRPQGSVPRAVPGSPVGPSTSTHSEDRHGPSSSVGTVIGTGTGGLVEAGGQPQPRSSET 70 Query: 81 GSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASPEEPGEPAPVPPGFGAVYGEP 140 G+ SP+ E+ P P+ + P P +P PA PPG A Sbjct: 71 N--GSPSPDPPPGLRGEGTREKSLDPLPQAAM----PRGPAQP--PAQRPPG-PAASSSA 121 Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSLTALRLLLADAYSGRMAGVR 200 V R R+ + + R AS D QG A G AG R Sbjct: 122 RRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDP---QGE---------APGEGGSPAG-R 168 Query: 201 PDNVAEVVAGARRL----QLPGA----------AQRATD-----AVGPQLSLANCYEVLS 241 + E AR+L Q PG + RA + A+ +L L +C +VL+ Sbjct: 169 SGALTEKQEEARKLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALRRRLDLGSCLDVLA 228 Query: 242 AAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAAL 301 A++ L Y MSD+ L VL +P ++ RLS A+R+ +L R GRA L L Sbjct: 229 FAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLSAADRERILSLRTGRGRAVLGVLVL 288 Query: 302 ------GPAGERAGSRPQSPSGDADARGD--AAVYCFHAAAGEWRELTRLPEGAPARGCG 353 G +G G R + P A A ++ F+ WR LT++PE AP RGCG Sbjct: 289 PSLYQGGRSGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCG 348 Query: 354 LCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGH 413 LC ++NYLF+AGG+ +G +A S++VFCYNP T+ WS VRP++QAR+QL+L+ALDG Sbjct: 349 LCTMHNYLFLAGGIRGSG--AKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGL 406 Query: 414 LYAVGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKY 473 LYA+GGECL S+E YDPR D W P APLP G F VAHEA C G+IYV+GG LFYRLL+Y Sbjct: 407 LYAIGGECLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLRY 466 Query: 474 DPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQ 533 P +D W ECP S+S RS+D+VAL GF+YRFDL RG G +V RY+ + Sbjct: 467 SPVKDAWDECPYSASHRRSSDIVALGGFLYRFDL--LRG-------VGAAVMRYNTVTGS 517 Query: 534 WSPCVA-PLRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFE 592 WS + PL P P C L IYC++ T F G Q E Sbjct: 518 WSRAASLPLPAPA------PLHCTTLGNTIYCLNPQVTATF------TVSGGTAQFQAKE 565 Query: 593 ALGAPLDVRGVLIPFALSLP 612 PL GVL PF L+LP Sbjct: 566 LQPFPLGSTGVLSPFILTLP 585 >gi|116089333 kelch domain containing 7A [Homo sapiens] Length = 777 Score = 287 bits (734), Expect = 2e-77 Identities = 166/368 (45%), Positives = 212/368 (57%), Gaps = 43/368 (11%) Query: 208 VAGARRLQLPGAAQRATDAVGPQ--LSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLE 265 VAG +P T A PQ L L NCYEVL+ AKRQ L L++AAY MS++YL+ Sbjct: 410 VAGTNFFHIP-----LTPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQ 464 Query: 266 VLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDA 325 VLR P ++G LSGAER+L+L+RRLR GR +L+ A + P + G Sbjct: 465 VLRSPDIYGCLSGAERELILQRRLR-GRQYLVVADVCPKEDSGG---------------- 507 Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385 + C+ WR L R+P A +RGC +C L+NYLFV G G +PS +VFCY Sbjct: 508 -LCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGH----QPSSRVFCY 562 Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRGA 445 NP T WS V PL QAR RL+ALDGHLYA+GGECL SVERYDPR DRW PLP Sbjct: 563 NPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDT 622 Query: 446 FAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRF 505 FA+AH AT EI+V+GGSL + L ++ + W P S++R+A+MVA++GF+YRF Sbjct: 623 FALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF 682 Query: 506 DLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565 DL+ S G++V R + W C A R P F+CA +D IYCV Sbjct: 683 DLNRS---------LGIAVYRCSASTRLWYEC-ATYRTPYP----DAFQCAVVDNLIYCV 728 Query: 566 SRAGTWRF 573 R T F Sbjct: 729 GRRSTLCF 736 >gi|55749726 kelch domain containing 5 [Homo sapiens] Length = 505 Score = 125 bits (315), Expect = 9e-29 Identities = 130/460 (28%), Positives = 196/460 (42%), Gaps = 70/460 (15%) Query: 155 KAVLAARSDYFRA-------------RASRDVLRVQGVSLTALRLLL-----ADAYSGRM 196 K L +SDYFRA +V +++G+S LRL+L A G + Sbjct: 20 KRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRLVLDFINAGGAREGWL 79 Query: 197 AGVRPDN---------------VAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLS 241 G R + ++E+V A LQ+ Q Q+ L NC E+ Sbjct: 80 LGPRGEKGGGVDEDEEMDEVSLLSELVEAASFLQVTSLLQLLLS----QVRLNNCLEMYR 135 Query: 242 AAKRQRLNELRDAAYCFMSDHYLEVLREPA--VFGRLSGAERDLLLRRRLRAGRAHLLAA 299 A+ L +L++A FM H+ EVL +P + G A D+ L++RLR R Sbjct: 136 LAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSLKQRLREARM-TGTP 194 Query: 300 ALGPAGERAGSRPQSPSGDADARGDA-AVYCFHAAAGEWRELTRL--PEGAPARGCGLCV 356 L G+ G P +G+ ++ + W L P+ RG G + Sbjct: 195 VLVALGDFLGG----PLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAI 250 Query: 357 LYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYA 416 L NYLF+ GG + A S YNP+T+ W V + Q RS +L+A++ LYA Sbjct: 251 LDNYLFIVGGYRITSQEISAAHS-----YNPSTNEWLQVASMNQKRSNFKLVAVNSKLYA 305 Query: 417 VGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLK 472 +GG+ + +VE Y+P D W VAPLP A C G+IYV GG +L+ Sbjct: 306 IGGQAVSNVECYNPEQDAWNFVAPLPNP--LAEFSACECKGKIYVIGGYTTRDRNMNILQ 363 Query: 473 YDPRRDEWQECPCSSSRERSADMVALDGFIY-----RFDLSGSRGEAQAAGPSGVSVSRY 527 Y P D W R MV+++ IY +L +R +Q+ ++V Y Sbjct: 364 YCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQS--EDMLTVQSY 421 Query: 528 HCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCVSR 567 + + +QW L+ +GL CA + IY +SR Sbjct: 422 NTVTRQW----LYLKENTSKSGLN-LTCALHNDGIYIMSR 456 >gi|55925604 kelch-like 18 [Homo sapiens] Length = 574 Score = 110 bits (274), Expect = 5e-24 Identities = 119/465 (25%), Positives = 180/465 (38%), Gaps = 59/465 (12%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLR-------VQGVSLTALRLLLADAYS 193 D+ L++ + AH+ VLAA YF A + D++ +QG+ +AL L+ AY+ Sbjct: 39 DVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYN 98 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 G +A + NV ++ GA LQL + +L NC V A+ L D Sbjct: 99 GNLA-IDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYD 157 Query: 254 AAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRA-GRAHLLAAALGPAG-ERAGSR 311 AA F+ H++EV +L+ R L + AAL +R Sbjct: 158 AANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRG 217 Query: 312 PQSPSGDADAR--------------GDAAVYCFHAA---AGEWRELTRLPEGAP------ 348 P P ++ R D V C H E ++ +PE P Sbjct: 218 PYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFR 277 Query: 349 ARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLL 408 R + ++ GG+ AG + V ++P + W RP+ ARS++ + Sbjct: 278 TRPRCCTSIAGLIYAVGGLNSAGDS-----LNVVEVFDPIANCWERCRPMTTARSRVGVA 332 Query: 409 ALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG 464 ++G LYA+GG L +VE Y+P D W V + A+ G+IYV GG Sbjct: 333 VVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG--TVVLDGQIYVCGG 390 Query: 465 ----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPS 520 S + Y P D+W SS +A + +G IY +SG Q Sbjct: 391 YDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIY---VSGGHDGLQIFS-- 445 Query: 521 GVSVSRYHCLAKQWSPCVAPL----RLPGGPTGLQPFRCAALDGA 561 SV Y+ W P L R G + F C DG+ Sbjct: 446 --SVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488 Score = 52.4 bits (124), Expect = 1e-06 Identities = 34/93 (36%), Positives = 45/93 (48%), Gaps = 10/93 (10%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412 G L + +FV GG +G A Y+ D W + P+ RS++ L+A G Sbjct: 471 GAASLGSKMFVCGGYDGSGFLSIAE------MYSSVADQWCLIVPMHTRRSRVSLVASCG 524 Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL 441 LYAVGG L SVE YDP D W +AP+ Sbjct: 525 RLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 557 >gi|55925608 kelch-like 21 [Homo sapiens] Length = 597 Score = 104 bits (260), Expect = 2e-22 Identities = 125/432 (28%), Positives = 173/432 (40%), Gaps = 101/432 (23%) Query: 141 DLVLEVSGRR-LRAHKAVLAARSDYFRA------RASR-DVLRVQGVSLTALRLLLADAY 192 D+ LE +G R AH+AVLAA S YFRA R SR + +R+ GV L+LLL +Y Sbjct: 36 DVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSY 95 Query: 193 SGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEV------------L 240 +GR+A V DN ++ A LQ P + + QL LANC ++ Sbjct: 96 TGRVA-VSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLA 154 Query: 241 SAAKR--------------------QRLNELRDAAYCFMSDH------------------ 262 SAA+R + L LRD C + Sbjct: 155 SAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRA 214 Query: 263 -----YLEVLREPAV--FGRLSGAERDLLLRR-----RLRAGRAHLLAAALG--PAGERA 308 LE +R P V F L+ E + L+ R RL AA G Sbjct: 215 AHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCP 274 Query: 309 GSRPQSPSG-----------DADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVL 357 RP+ +G D D V C++ G+WR L P+ G + L Sbjct: 275 RMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGG-GYSIVAL 333 Query: 358 YNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAV 417 N ++V GG DG +R D V+ YN + + W+ V P+ +AR LDG LY V Sbjct: 334 GNDIYVTGG-----SDG-SRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVV 387 Query: 418 GGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATT-CHGEIYVSG---GSLFYRLLKY 473 + S ERYD D W + P+ + + + +TT C G +Y G G + Y Sbjct: 388 AAD---STERYDHTTDSWEALQPM---TYPMDNCSTTACRGRLYAIGSLAGKETMVMQCY 441 Query: 474 DPRRDEWQECPC 485 DP D W C Sbjct: 442 DPDTDLWSLVDC 453 Score = 41.6 bits (96), Expect = 0.002 Identities = 25/73 (34%), Positives = 30/73 (41%), Gaps = 5/73 (6%) Query: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG-----ECLLSVERYDPRAD 433 S +V YNP + W + + Q L L G LY GG E VE YDP Sbjct: 479 SAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETR 538 Query: 434 RWAPVAPLPRGAF 446 W+ V LP F Sbjct: 539 AWSVVGRLPEPTF 551 Score = 29.6 bits (65), Expect = 8.7 Identities = 22/71 (30%), Positives = 32/71 (45%), Gaps = 7/71 (9%) Query: 325 AAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFC 384 A V ++ EW ++ + + G L VL L+V+GG D SD V Sbjct: 480 AEVDVYNPTRNEWDKIPSMNQVHV--GGSLAVLGGKLYVSGGY-----DNTFELSDVVEA 532 Query: 385 YNPATDSWSAV 395 Y+P T +WS V Sbjct: 533 YDPETRAWSVV 543 >gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] Length = 571 Score = 95.5 bits (236), Expect = 1e-19 Identities = 71/233 (30%), Positives = 111/233 (47%), Gaps = 28/233 (12%) Query: 344 PEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRA--RPSDQVFCYNPATDSWSAVRPLRQA 401 P P G+CVL ++V GG+A G + + V C+NP T++W+++ + ++ Sbjct: 316 PLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNES 375 Query: 402 RSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTC 455 RS L ++ L G LYA+GG L SVE+Y P+ +W PVAP+ R FA A Sbjct: 376 RSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFA----AAVL 431 Query: 456 HGEIYVSGG---SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRG 512 G IY GG + + +YDP +D W+ + + + + GFI F + G G Sbjct: 432 DGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFI--FVVGGHNG 489 Query: 513 EAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565 + + S+ RY QW+ C P++ P G A +D +Y V Sbjct: 490 VSHLS-----SIERYDPHQNQWTVC-RPMKEPRTGVG-----AAVIDNYLYVV 531 Score = 57.4 bits (137), Expect = 4e-08 Identities = 42/140 (30%), Positives = 58/140 (41%), Gaps = 18/140 (12%) Query: 350 RGC-GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLL 408 R C VL ++ GG PA + R Y+P+ DSW V + R + Sbjct: 423 RSCFAAAVLDGMIYAIGGYGPAHMNSVER-------YDPSKDSWEMVASMADKRIHFGVG 475 Query: 409 ALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG 464 + G ++ VGG L S+ERYDP ++W P+ V A +YV GG Sbjct: 476 VMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVG--AAVIDNYLYVVGG 533 Query: 465 ----SLFYRLLKYDPRRDEW 480 S + KYDP D W Sbjct: 534 HSGSSYLNTVQKYDPISDTW 553 >gi|24308181 kelch-like 9 [Homo sapiens] Length = 617 Score = 93.2 bits (230), Expect = 6e-19 Identities = 85/299 (28%), Positives = 126/299 (42%), Gaps = 27/299 (9%) Query: 334 AGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWS 393 A EWR L P AP G+ V+ N+L+V GG + G+ D VF ++P + W Sbjct: 324 AQEWRSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAV-DTVFRFDPRYNKWM 380 Query: 394 AVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAFAVA 449 V L + R+ L AL GHLYAVGG L +VE Y+PR + W+ VA + + Sbjct: 381 QVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHY--G 438 Query: 450 HEATTCHGEIYVSGG----SLFYRLLKYDPRRDEW-QECPCSSSRERSADMVALDGFIYR 504 H T G +Y+SGG + L+ +DP D+W Q+ P ++ R D Sbjct: 439 HAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKL--- 495 Query: 505 FDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYC 564 + + G+ + +S Y QW+P A LR G A + IY Sbjct: 496 YVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLR------GQSDVGVAVFENKIYV 549 Query: 565 VSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDVRGVLIPFALSLPEKPPRGEQGAP 623 V +W + E D + + P + G+ A +L PP G+P Sbjct: 550 VG-GYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIR---ACTLTVFPPEENPGSP 604 Score = 42.0 bits (97), Expect = 0.002 Identities = 30/115 (26%), Positives = 48/115 (41%), Gaps = 15/115 (13%) Query: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE---------CLLSVERYD 429 S ++ Y+ W ++ P+ R Q + + LY VGG+ + +V R+D Sbjct: 314 SKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 373 Query: 430 PRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEW 480 PR ++W VA L + G +Y GG L Y+PR +EW Sbjct: 374 PRYNKWMQVASL--NEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEW 426 Score = 35.8 bits (81), Expect = 0.12 Identities = 26/105 (24%), Positives = 52/105 (49%), Gaps = 8/105 (7%) Query: 154 HKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYSGRMAGVRPDNVAE 206 H+A++A+ SDYF+A + + +++ GV+ L+ ++ Y+ +++ + DN+ + Sbjct: 66 HRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLS-LNMDNLQD 124 Query: 207 VVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNEL 251 + A LQ+ + +SL NC EV A L E+ Sbjct: 125 TLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEV 169 >gi|40807500 kelch-like 20 [Homo sapiens] Length = 609 Score = 92.8 bits (229), Expect = 8e-19 Identities = 121/472 (25%), Positives = 189/472 (40%), Gaps = 75/472 (15%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLR-------VQGVSLTALRLLLADAYS 193 D+VL V +++ AH+ +L+A S YFRA + ++ ++ + A+ LL+ AY+ Sbjct: 69 DVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYT 128 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 ++ V NV ++ A LQL + + + QL +NC + + A EL Sbjct: 129 SQIT-VEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLR 187 Query: 254 AAYCFMSDHYLEVLR-------------------------EPAVFGRLSGAERDLLLRRR 288 A F ++ EV+ E VF + + + RR Sbjct: 188 IADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERR 247 Query: 289 LRAGRA--HLLAAALGP--AGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLP 344 + + H+ L P GS P S D + R + + R L + P Sbjct: 248 PQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKS-DEECRDLVDEAKNYLLLPQERPLMQGP 306 Query: 345 EGAPAR--GCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQAR 402 P + CG LF GG G A S V Y+P T+ W V + + R Sbjct: 307 RTRPRKPIRCG-----EVLFAVGGWC----SGDAISS--VERYDPQTNEWRMVASMSKRR 355 Query: 403 SQLRLLALDGHLYAVGG----ECLLSVERYDPRADRW-APVAPLPRGAFAVAHEATTCHG 457 + + LD LYAVGG L SVERYDP+ ++W + VAP +V G Sbjct: 356 CGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVG--VAVLGG 413 Query: 458 EIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGE 513 +Y GG S + +YDP+ ++W S+R + L GF+Y + GS G Sbjct: 414 FLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYA--VGGSDGT 471 Query: 514 AQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565 + +V RY+ +W +AP+ T + CA IY V Sbjct: 472 SPLN-----TVERYNPQENRWH-TIAPM-----GTRRKHLGCAVYQDMIYAV 512 Score = 79.7 bits (195), Expect = 7e-15 Identities = 79/272 (29%), Positives = 111/272 (40%), Gaps = 40/272 (14%) Query: 323 GDA--AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSD 380 GDA +V + EWR + + + G G+ VL + L+ GG DG + + Sbjct: 329 GDAISSVERYDPQTNEWRMVASMSKRRC--GVGVSVLDDLLYAVGG-----HDGSSY-LN 380 Query: 381 QVFCYNPATDSWSA-VRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRW 435 V Y+P T+ WS+ V P R+ + + L G LYAVGG+ CL VERYDP+ ++W Sbjct: 381 SVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKW 440 Query: 436 APVAPLPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRER 491 VA + VA G +Y GG S + +Y+P+ + W +R + Sbjct: 441 TRVASMSTRRLGVA--VAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRK 498 Query: 492 SADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGL- 550 IY G R + S RY+ QWSP VA G GL Sbjct: 499 HLGCAVYQDMIYAV---GGRDDTTELS----SAERYNPRTNQWSPVVAMTSRRSG-VGLA 550 Query: 551 ----QPFRCAALDGAIYCVS------RAGTWR 572 Q DG Y + A TWR Sbjct: 551 VVNGQLMAVGGFDGTTYLKTIEVFDPDANTWR 582 >gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] Length = 709 Score = 90.9 bits (224), Expect = 3e-18 Identities = 101/448 (22%), Positives = 177/448 (39%), Gaps = 63/448 (14%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYS 193 D++L RR+ AH+ VL++ SDYF A + DV ++++GV +L L+ AY+ Sbjct: 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 GR+ ++ DN+ +++ A LQL + + QL +NC + S A Q +L Sbjct: 235 GRLE-LKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK 293 Query: 254 AAYCFMSDHYLEVLR--------------------------EPAVFGRLSGAERDLLLRR 287 A+ + +H++EV+R E + L+ DL RR Sbjct: 294 VAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRR 353 Query: 288 R-LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEG 346 + L A++ L P D + + + E R + + P Sbjct: 354 KDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRT 413 Query: 347 APARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLR 406 P + LF GG+ + + + Y+ T+ W+ V + R Q Sbjct: 414 KPRKS-----TVGTLFAVGGM------DSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG 462 Query: 407 LLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVS 462 + LD LY VGG + L +VE Y+P+ W+ + P+ + G +Y Sbjct: 463 VAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLG--VAVLEGPMYAV 520 Query: 463 GG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAG 518 GG S + ++DP+ +W S+ + + L G +Y + G G + Sbjct: 521 GGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYA--VGGRDGSSCLK- 577 Query: 519 PSGVSVSRYHCLAKQWSPCVAPLRLPGG 546 SV + +W+ C + GG Sbjct: 578 ----SVECFDPHTNKWTLCAQMSKRRGG 601 Score = 77.0 bits (188), Expect = 5e-14 Identities = 55/161 (34%), Positives = 79/161 (49%), Gaps = 20/161 (12%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412 G+ VL + L+V GG DG + + V CYNP T +WS + P+ R L + L+G Sbjct: 462 GVAVLDDKLYVVGG-----RDG-LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEG 515 Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGGSL 466 +YAVGG L +VER+DP+A +W VA + PR VA G++Y GG Sbjct: 516 PMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVA----VLSGKLYAVGGRD 571 Query: 467 FYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGFIY 503 LK +DP ++W C S R + +G +Y Sbjct: 572 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 612 Score = 60.5 bits (145), Expect = 5e-09 Identities = 40/123 (32%), Positives = 58/123 (47%), Gaps = 6/123 (4%) Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385 +V CF +W ++ + G G+ L+ GG + +R SD V Y Sbjct: 578 SVECFDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY 635 Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL 441 +P TD W+AV + +R + + L LYAVGG L +VE YDP+ + W VAPL Sbjct: 636 DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 695 Query: 442 PRG 444 G Sbjct: 696 CLG 698 Score = 30.4 bits (67), Expect = 5.1 Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 6/51 (11%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARS 403 G+C+L + L+ GG DG+A + V Y+P T+ W+ V PL R+ Sbjct: 656 GVCLLGDKLYAVGGY-----DGQAY-LNTVEAYDPQTNEWTQVAPLCLGRA 700 >gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] Length = 755 Score = 90.9 bits (224), Expect = 3e-18 Identities = 101/448 (22%), Positives = 177/448 (39%), Gaps = 63/448 (14%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYS 193 D++L RR+ AH+ VL++ SDYF A + DV ++++GV +L L+ AY+ Sbjct: 221 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 280 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 GR+ ++ DN+ +++ A LQL + + QL +NC + S A Q +L Sbjct: 281 GRLE-LKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK 339 Query: 254 AAYCFMSDHYLEVLR--------------------------EPAVFGRLSGAERDLLLRR 287 A+ + +H++EV+R E + L+ DL RR Sbjct: 340 VAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRR 399 Query: 288 R-LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEG 346 + L A++ L P D + + + E R + + P Sbjct: 400 KDLSKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRT 459 Query: 347 APARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLR 406 P + LF GG+ + + + Y+ T+ W+ V + R Q Sbjct: 460 KPRKS-----TVGTLFAVGGM------DSTKGATSIEKYDLRTNMWTPVANMNGRRLQFG 508 Query: 407 LLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVS 462 + LD LY VGG + L +VE Y+P+ W+ + P+ + G +Y Sbjct: 509 VAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLG--VAVLEGPMYAV 566 Query: 463 GG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAG 518 GG S + ++DP+ +W S+ + + L G +Y + G G + Sbjct: 567 GGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYA--VGGRDGSSCLK- 623 Query: 519 PSGVSVSRYHCLAKQWSPCVAPLRLPGG 546 SV + +W+ C + GG Sbjct: 624 ----SVECFDPHTNKWTLCAQMSKRRGG 647 Score = 77.0 bits (188), Expect = 5e-14 Identities = 55/161 (34%), Positives = 79/161 (49%), Gaps = 20/161 (12%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412 G+ VL + L+V GG DG + + V CYNP T +WS + P+ R L + L+G Sbjct: 508 GVAVLDDKLYVVGG-----RDG-LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEG 561 Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGGSL 466 +YAVGG L +VER+DP+A +W VA + PR VA G++Y GG Sbjct: 562 PMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVA----VLSGKLYAVGGRD 617 Query: 467 FYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGFIY 503 LK +DP ++W C S R + +G +Y Sbjct: 618 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 658 Score = 60.5 bits (145), Expect = 5e-09 Identities = 40/123 (32%), Positives = 58/123 (47%), Gaps = 6/123 (4%) Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385 +V CF +W ++ + G G+ L+ GG + +R SD V Y Sbjct: 624 SVECFDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY 681 Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL 441 +P TD W+AV + +R + + L LYAVGG L +VE YDP+ + W VAPL Sbjct: 682 DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 741 Query: 442 PRG 444 G Sbjct: 742 CLG 744 Score = 30.4 bits (67), Expect = 5.1 Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 6/51 (11%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARS 403 G+C+L + L+ GG DG+A + V Y+P T+ W+ V PL R+ Sbjct: 702 GVCLLGDKLYAVGGY-----DGQAY-LNTVEAYDPQTNEWTQVAPLCLGRA 746 >gi|45643138 kelch-like 13 [Homo sapiens] Length = 655 Score = 88.6 bits (218), Expect = 2e-17 Identities = 73/241 (30%), Positives = 109/241 (45%), Gaps = 23/241 (9%) Query: 334 AGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWS 393 A EW+ L P AP G+ V+ N+L+V GG + G+ D VF ++P + W Sbjct: 366 AHEWKSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAV-DTVFRFDPRYNKWM 422 Query: 394 AVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAFAVA 449 V L + R+ L AL G+LYAVGG L +VE Y+PR + W VA + + Sbjct: 423 QVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHY--G 480 Query: 450 HEATTCHGEIYVSGG----SLFYRLLKYDPRRDEW-QECPCSSSRERSADMVALDGFIYR 504 H T G +Y+SGG + L+ +DP D+W Q+ P ++ R M + +Y Sbjct: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHC-MCTVGERLY- 538 Query: 505 FDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYC 564 + G+ + +S Y + QW+P A LR G A + IY Sbjct: 539 -VIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLR------GQSDVGVAVFENKIYV 591 Query: 565 V 565 V Sbjct: 592 V 592 Score = 68.6 bits (166), Expect = 2e-11 Identities = 48/182 (26%), Positives = 78/182 (42%), Gaps = 26/182 (14%) Query: 317 GDADARGDA-AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGR 375 G +A G+ V C++ EW + ++ E P G V ++++GG+ Sbjct: 447 GGRNAAGELPTVECYNPRTNEWTYVAKMSE--PHYGHAGTVYGGVMYISGGIT------H 498 Query: 376 ARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG---------ECLLSVE 426 ++ C++P TD W P+ R + + LY +GG + +LS E Sbjct: 499 DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558 Query: 427 RYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYR------LLKYDPRRDEW 480 Y P D+W P+A + RG V +IYV GG + + KYDP +DEW Sbjct: 559 YYSPILDQWTPIAAMLRGQSDVG--VAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616 Query: 481 QE 482 + Sbjct: 617 HK 618 Score = 44.3 bits (103), Expect = 3e-04 Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 11/97 (11%) Query: 354 LCVLYNYLFVAGGVAPAGPDGRARPSDQVFC--YNPATDSWSAVRPLRQARSQLRLLALD 411 +C + L+V GG G D + C Y+P D W+ + + + +S + + + Sbjct: 530 MCTVGERLYVIGGNHFRGTSDY---DDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFE 586 Query: 412 GHLYAVGG-----ECLLS-VERYDPRADRWAPVAPLP 442 +Y VGG C++ V++YDP D W V LP Sbjct: 587 NKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLP 623 Score = 40.8 bits (94), Expect = 0.004 Identities = 30/115 (26%), Positives = 48/115 (41%), Gaps = 15/115 (13%) Query: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE---------CLLSVERYD 429 S ++ Y+ W ++ P+ R Q + + LY VGG+ + +V R+D Sbjct: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415 Query: 430 PRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEW 480 PR ++W VA L + G +Y GG L Y+PR +EW Sbjct: 416 PRYNKWMQVASL--NEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEW 468 Score = 37.0 bits (84), Expect = 0.054 Identities = 28/121 (23%), Positives = 57/121 (47%), Gaps = 8/121 (6%) Query: 154 HKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYSGRMAGVRPDNVAE 206 H+ ++A+ SDYF+A + + +++ GVS LR ++ Y+ +++ + DN+ + Sbjct: 108 HRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLS-LNMDNLQD 166 Query: 207 VVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEV 266 + A LQ+ + ++L NC EV A L E+ F+ ++ + Sbjct: 167 TLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPAL 226 Query: 267 L 267 L Sbjct: 227 L 227 >gi|38194229 kelch-like 17 [Homo sapiens] Length = 642 Score = 87.8 bits (216), Expect = 3e-17 Identities = 142/558 (25%), Positives = 201/558 (36%), Gaps = 125/558 (22%) Query: 93 SPEERACPEEPAAPSPEPRVWLEDPASPE----EPGEPAPVPPGFGAV------------ 136 SPE + P AP P P P +PE P + P P GAV Sbjct: 14 SPEHGSPGPGPEAPPPPP----PQPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVAH 69 Query: 137 -----YGEP--------------DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQ 177 Y + D+VL V+ + +RAHK VLA+ S YF A + ++ + Sbjct: 70 NSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR 129 Query: 178 GVSLT-------ALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQ 230 +T AL L+ AY+ + V NV ++ A LQL G + Q Sbjct: 130 QTHVTLHDIDPQALDQLVQFAYTAEIV-VGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188 Query: 231 LSLANCY------------EVLSAAKRQRLNELRDAAYC-------------FMSDHYLE 265 L +NC ++L AA R L D A +S L Sbjct: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248 Query: 266 VLREPAVFGR-LSGAERDLLLRRR-----LRAGRAHLLAAALGPAGERAGSRPQSPSGDA 319 V E V+ LS + D+ RR+ ++ R LL+ A S + Sbjct: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308 Query: 320 DARGDAAVYCF----HAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGR 375 D +A + G R R EGA LF GG + G Sbjct: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGP----------VLFAVGGGSLFAIHGD 358 Query: 376 ARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPR 431 Y+ TD W V + R+++ + A+ LYAVGG L +VE YDP Sbjct: 359 CE------AYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPV 412 Query: 432 ADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG----SLFYRLLKYDPRRDEWQECPC 485 + W P + R VA HG +Y +GG S +YDP W Sbjct: 413 TNTWQPEVSMGTRRSCLGVA----ALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAA 468 Query: 486 SSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPG 545 S+R R + LDG +Y + G + A +V +Y WSP VA + Sbjct: 469 MSTRRRYVRVATLDGNLYA--VGGYDSSSHLA-----TVEKYEPQVNVWSP-VASMLSRR 520 Query: 546 GPTGLQPFRCAALDGAIY 563 G+ A L+GA+Y Sbjct: 521 SSAGV-----AVLEGALY 533 Score = 83.6 bits (205), Expect = 5e-16 Identities = 73/262 (27%), Positives = 119/262 (45%), Gaps = 39/262 (14%) Query: 290 RAGRAHLLA------AALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRL 343 R R H++A A +G A G+R + G A V + W+ + Sbjct: 365 RTDRWHVVASMSTRRARVGVAA--VGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSM 422 Query: 344 PEGAPARGC-GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQAR 402 R C G+ L+ L+ AGG A A Y+P T +W++V + R Sbjct: 423 ---GTRRSCLGVAALHGLLYSAGGYDGASCLNSAER------YDPLTGTWTSVAAMSTRR 473 Query: 403 SQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCH 456 +R+ LDG+LYAVGG L +VE+Y+P+ + W+PVA + R + VA Sbjct: 474 RYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVA----VLE 529 Query: 457 GEIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRG 512 G +YV+GG S + +Y P+ W+ + R + D+VA+DG++Y + G+ G Sbjct: 530 GALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYA--VGGNDG 587 Query: 513 EAQAAGPSGVSVSRYHCLAKQW 534 + S S+ +Y+ +W Sbjct: 588 SS-----SLNSIEKYNPRTNKW 604 Score = 69.7 bits (169), Expect = 8e-12 Identities = 41/123 (33%), Positives = 56/123 (45%), Gaps = 10/123 (8%) Query: 385 YNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAP 440 Y P + WS V + RS + L+G LY GG CL SVERY P+A W VAP Sbjct: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAP 562 Query: 441 LPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMV 496 + H+ G +Y GG S + KY+PR ++W C +R S + Sbjct: 563 M--NIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVA 620 Query: 497 ALD 499 L+ Sbjct: 621 VLE 623 Score = 48.5 bits (114), Expect = 2e-05 Identities = 52/180 (28%), Positives = 67/180 (37%), Gaps = 28/180 (15%) Query: 393 SAVRPLRQARSQLRLLALDG-HLYAVGGECLLSVERYDPRADRWAPVAPLP--RGAFAVA 449 S RP R + L A+ G L+A+ G+C E YD R DRW VA + R VA Sbjct: 330 SRTRPRRCEGAGPVLFAVGGGSLFAIHGDC----EAYDTRTDRWHVVASMSTRRARVGVA 385 Query: 450 HEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSG 509 + G S + YDP + WQ +R + AL G +Y Sbjct: 386 AVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLY------ 439 Query: 510 SRGEAQAAGPSGV----SVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565 A G G S RY L W+ A T + R A LDG +Y V Sbjct: 440 -----SAGGYDGASCLNSAERYDPLTGTWTSVAAM------STRRRYVRVATLDGNLYAV 488 >gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] Length = 624 Score = 85.5 bits (210), Expect = 1e-16 Identities = 69/221 (31%), Positives = 98/221 (44%), Gaps = 22/221 (9%) Query: 330 FHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPAT 389 ++ + G W L L P G CV+ L+ GG PDG S + CYNP T Sbjct: 345 YNPSDGTWLRLADLQ--VPRSGLAGCVVGGLLYAVGG-RNNSPDGNT-DSSALDCYNPMT 400 Query: 390 DSWSAVRPLRQARSQLRLLALDGHLYAVGGE--CL--LSVERYDPRADRWAPVAPLPRGA 445 + WS P+ R+++ + +DGH+YAVGG C+ SVERY+P D W VAP+ Sbjct: 401 NQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRR 460 Query: 446 FAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGF 501 V + +Y GG L Y P R+EW+ ++ A + L Sbjct: 461 IGVG--VAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNC 518 Query: 502 IYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLR 542 IY G G+ Q SV RY + W+ VAP++ Sbjct: 519 IYA--AGGYDGQDQLN-----SVERYDVETETWT-FVAPMK 551 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/129 (32%), Positives = 64/129 (49%), Gaps = 12/129 (9%) Query: 329 CFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPA 388 C++ EWR +T + G G+CVL+N ++ AGG DG+ + + V Y+ Sbjct: 489 CYYPERNEWRMITAM--NTIRSGAGVCVLHNCIYAAGGY-----DGQDQ-LNSVERYDVE 540 Query: 389 TDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444 T++W+ V P++ RS L + G +Y +GG L SVE YDP D W+ V + G Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600 Query: 445 AFAVAHEAT 453 V T Sbjct: 601 RSGVGVAVT 609 Score = 65.1 bits (157), Expect = 2e-10 Identities = 89/403 (22%), Positives = 149/403 (36%), Gaps = 76/403 (18%) Query: 153 AHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDNVA 205 AHK VLA+ S F+A +V+ ++G+ + L+ AY+ ++ + V Sbjct: 95 AHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS-MGEKCVL 153 Query: 206 EVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLE 265 V+ GA Q+ + +D + QL +N + + A++ EL A ++ H+ E Sbjct: 154 HVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGE 213 Query: 266 VLREPAVFG-------------------------------RLSGAERDLLLRRRLRAGRA 294 V ++ F + +R ++ LRA R Sbjct: 214 VAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRC 273 Query: 295 HLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGL 354 H L + QS S C + ELT L + C Sbjct: 274 HSLTPNFLQMQLQKCEILQSDS-----------RCKDYLVKIFEELT-LHKPTQVMPCRA 321 Query: 355 CVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHL 414 + ++ AGG + + YNP+ +W + L+ RS L + G L Sbjct: 322 PKVGRLIYTAGGYF-------RQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLL 374 Query: 415 YAVGGE--------CLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG 464 YAVGG +++ Y+P ++W+P AP+ PR V G IY GG Sbjct: 375 YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVG----VIDGHIYAVGG 430 Query: 465 S----LFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIY 503 S + +Y+P RDEW +R + L+ +Y Sbjct: 431 SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY 473 Score = 65.1 bits (157), Expect = 2e-10 Identities = 63/244 (25%), Positives = 89/244 (36%), Gaps = 58/244 (23%) Query: 289 LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAP 348 L+ R+ L +G G R SP G+ D+ +A+ C++ +W P P Sbjct: 358 LQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDS---SALDCYNPMTNQWSPCA--PMSVP 412 Query: 349 ARGCGLCVLYNYLFVAGG----------------------VAP----------------- 369 G+ V+ +++ GG VAP Sbjct: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472 Query: 370 ---AGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECL 422 G DG R + CY P + W + + RS + L +YA GG + L Sbjct: 473 YAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531 Query: 423 LSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRD 478 SVERYD + W VAP+ A+ T G IYV GG + L YDP D Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALG--ITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589 Query: 479 EWQE 482 W E Sbjct: 590 TWSE 593 >gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] Length = 624 Score = 85.5 bits (210), Expect = 1e-16 Identities = 69/221 (31%), Positives = 98/221 (44%), Gaps = 22/221 (9%) Query: 330 FHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPAT 389 ++ + G W L L P G CV+ L+ GG PDG S + CYNP T Sbjct: 345 YNPSDGTWLRLADLQ--VPRSGLAGCVVGGLLYAVGG-RNNSPDGNT-DSSALDCYNPMT 400 Query: 390 DSWSAVRPLRQARSQLRLLALDGHLYAVGGE--CL--LSVERYDPRADRWAPVAPLPRGA 445 + WS P+ R+++ + +DGH+YAVGG C+ SVERY+P D W VAP+ Sbjct: 401 NQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRR 460 Query: 446 FAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGF 501 V + +Y GG L Y P R+EW+ ++ A + L Sbjct: 461 IGVG--VAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNC 518 Query: 502 IYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLR 542 IY G G+ Q SV RY + W+ VAP++ Sbjct: 519 IYA--AGGYDGQDQLN-----SVERYDVETETWT-FVAPMK 551 Score = 68.2 bits (165), Expect = 2e-11 Identities = 42/129 (32%), Positives = 64/129 (49%), Gaps = 12/129 (9%) Query: 329 CFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPA 388 C++ EWR +T + G G+CVL+N ++ AGG DG+ + + V Y+ Sbjct: 489 CYYPERNEWRMITAM--NTIRSGAGVCVLHNCIYAAGGY-----DGQDQ-LNSVERYDVE 540 Query: 389 TDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444 T++W+ V P++ RS L + G +Y +GG L SVE YDP D W+ V + G Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600 Query: 445 AFAVAHEAT 453 V T Sbjct: 601 RSGVGVAVT 609 Score = 65.1 bits (157), Expect = 2e-10 Identities = 89/403 (22%), Positives = 149/403 (36%), Gaps = 76/403 (18%) Query: 153 AHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYSGRMAGVRPDNVA 205 AHK VLA+ S F+A +V+ ++G+ + L+ AY+ ++ + V Sbjct: 95 AHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASIS-MGEKCVL 153 Query: 206 EVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLE 265 V+ GA Q+ + +D + QL +N + + A++ EL A ++ H+ E Sbjct: 154 HVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGE 213 Query: 266 VLREPAVFG-------------------------------RLSGAERDLLLRRRLRAGRA 294 V ++ F + +R ++ LRA R Sbjct: 214 VAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRC 273 Query: 295 HLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGL 354 H L + QS S C + ELT L + C Sbjct: 274 HSLTPNFLQMQLQKCEILQSDS-----------RCKDYLVKIFEELT-LHKPTQVMPCRA 321 Query: 355 CVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHL 414 + ++ AGG + + YNP+ +W + L+ RS L + G L Sbjct: 322 PKVGRLIYTAGGYF-------RQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLL 374 Query: 415 YAVGGE--------CLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG 464 YAVGG +++ Y+P ++W+P AP+ PR V G IY GG Sbjct: 375 YAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVG----VIDGHIYAVGG 430 Query: 465 S----LFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIY 503 S + +Y+P RDEW +R + L+ +Y Sbjct: 431 SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLY 473 Score = 65.1 bits (157), Expect = 2e-10 Identities = 63/244 (25%), Positives = 89/244 (36%), Gaps = 58/244 (23%) Query: 289 LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAP 348 L+ R+ L +G G R SP G+ D+ +A+ C++ +W P P Sbjct: 358 LQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDS---SALDCYNPMTNQWSPCA--PMSVP 412 Query: 349 ARGCGLCVLYNYLFVAGG----------------------VAP----------------- 369 G+ V+ +++ GG VAP Sbjct: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472 Query: 370 ---AGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECL 422 G DG R + CY P + W + + RS + L +YA GG + L Sbjct: 473 YAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531 Query: 423 LSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRD 478 SVERYD + W VAP+ A+ T G IYV GG + L YDP D Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALG--ITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589 Query: 479 EWQE 482 W E Sbjct: 590 TWSE 593 >gi|157384932 hypothetical protein LOC390594 [Homo sapiens] Length = 458 Score = 85.1 bits (209), Expect = 2e-16 Identities = 90/314 (28%), Positives = 125/314 (39%), Gaps = 39/314 (12%) Query: 146 VSGRRLRAHKAVLAARSDYFRA------RASRDV-LRVQGVSLTALRLLLADAYSGRMAG 198 V G+ +A +A+L +FR R +R +R+ +S R L R A Sbjct: 13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPAL 72 Query: 199 VRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCF 258 D + + V A LQ P A+ + L+ NC + AA L ++ +A F Sbjct: 73 AAEDELLQAVECAAFLQAPALAR----FLEHNLTSDNCALLCDAAAAFGLRDVFHSAALF 128 Query: 259 MSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGD 318 + D ER+L L RA++ AAL P+ A S G Sbjct: 129 ICD-----------------GERELAAELALPEARAYV--AALRPSSYAAVSTHTPAPGF 169 Query: 319 ADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARP 378 + Y WR L LP A G+ L N L++ GGV A + Sbjct: 170 LEDASRTLCY-LDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKE----V 224 Query: 379 SDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADR 434 + FCY+P +W Q R L DG LYA+GGE + SVERYDP A Sbjct: 225 VELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGC 284 Query: 435 WAPVAPLPRGAFAV 448 W+ VA LP+ A V Sbjct: 285 WSFVADLPQPAAGV 298 Score = 35.4 bits (80), Expect = 0.16 Identities = 31/113 (27%), Positives = 39/113 (34%), Gaps = 13/113 (11%) Query: 429 DPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG------SLFYRLLKYDPRRDEWQE 482 D D W +A LP A + T ++Y+ GG + YDP W E Sbjct: 181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE 240 Query: 483 CPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWS 535 P + DG +Y GE Q S SV RY A WS Sbjct: 241 FPSPHQPRYDTALAGFDGRLYAIG-----GEFQRTPIS--SVERYDPAAGCWS 286 >gi|23397572 kelch-like 34 [Homo sapiens] Length = 644 Score = 84.0 bits (206), Expect = 4e-16 Identities = 65/201 (32%), Positives = 83/201 (41%), Gaps = 27/201 (13%) Query: 327 VYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSD------ 380 V F WR LT+LP P G +C N+LFV GG +P+G D Sbjct: 336 VVAFDVYNHRWRSLTQLP--TPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTA 393 Query: 381 QVFCYNPATDSWSAVRPLRQARSQL-------RLLALDGHLYAVGGECLLSVERYDPRAD 433 QV Y+P +W+ V +R+AR+ RLLA+ G GGE L SVE YD R D Sbjct: 394 QVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGG--LGAGGEVLASVEMYDLRRD 451 Query: 434 RWAPVAPLPRGAFAVAHEATTCHGEIYVSGG---------SLFYRLLKYDPRRDEWQECP 484 RW LPR A A G +Y+SGG S L P W + Sbjct: 452 RWTAAGALPRALHGHA-GAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVWSKKA 510 Query: 485 CSSSRERSADMVALDGFIYRF 505 + M L G ++ F Sbjct: 511 PMGTARFGHHMAVLRGAVFAF 531 Score = 54.7 bits (130), Expect = 3e-07 Identities = 57/216 (26%), Positives = 82/216 (37%), Gaps = 36/216 (16%) Query: 289 LRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGD--AAVYCFHAAAGEWRELTRLPEG 346 +R RAH A+G ER + G A G+ A+V + W LP Sbjct: 411 MREARAHFWCGAVG---ERLLA-----VGGLGAGGEVLASVEMYDLRRDRWTAAGALPRA 462 Query: 347 APARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLR 406 G ++++GG A G G + D ++ P WS P+ AR Sbjct: 463 LHGHA-GAVGDRGVVYISGGKAGRGEGGASSLRD-LYVLGPEEQVWSKKAPMGTARFGHH 520 Query: 407 LLALDGHLYAVGG--ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG 464 + L G ++A G E +ERYDP AD+W + PLP F C+G V Sbjct: 521 MAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLPYDRF--------CYGLAVVEET 572 Query: 465 SLFYRLLK--------------YDPRRDEWQECPCS 486 +L LK YD D W++ C+ Sbjct: 573 ALLLGGLKWRDSRQVPTRNVVGYDLDLDRWEDIGCA 608 Score = 45.4 bits (106), Expect = 2e-04 Identities = 40/138 (28%), Positives = 60/138 (43%), Gaps = 8/138 (5%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYS 193 D+ LE G AH+++LA SDYFRA + V+ + S L+ LL Y+ Sbjct: 30 DVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESRARVIHLHVPSAAGLQRLLDFIYT 89 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 ++ + D V + + A LQ+ A + QL+ NC + A R L D Sbjct: 90 AWLS-LSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAPENCCFAANVAARFGLAHTLD 148 Query: 254 AAYCFMSDHYLEVLREPA 271 AA + H E+L A Sbjct: 149 AAERCIVSHLQELLARGA 166 >gi|14780904 kelch-like 1 protein [Homo sapiens] Length = 748 Score = 81.6 bits (200), Expect = 2e-15 Identities = 64/211 (30%), Positives = 95/211 (45%), Gaps = 28/211 (13%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412 G+ V+ + LFV GG DG + + V CYNP T +W+ + P+ R L + L+G Sbjct: 500 GVAVIDDKLFVIGG-----RDG-LKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEG 553 Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG---- 464 +YAVGG L +VER+DP++ +W VA + V +G++Y GG Sbjct: 554 PIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVG--VAALNGKLYSVGGRDGS 611 Query: 465 SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVS- 523 S + YDP ++W C R + DGF+Y + G A + S Sbjct: 612 SCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLY------AVGGHDAPASNHCSR 665 Query: 524 ----VSRYHCLAKQWSPCVAPLRLPGGPTGL 550 V RY W+ VAPL +P G+ Sbjct: 666 LLDYVERYDPKTDTWT-MVAPLSMPRDAVGV 695 Score = 60.8 bits (146), Expect = 4e-09 Identities = 40/135 (29%), Positives = 72/135 (53%), Gaps = 8/135 (5%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYS 193 D++L V R++ AH+ VL++ SDYF A + DV ++++G+ AL L+ AY+ Sbjct: 213 DVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 272 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 G + ++ D + ++A A LQLP + + L +NC + + A Q EL Sbjct: 273 GCLE-LKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMK 331 Query: 254 AAYCFMSDHYLEVLR 268 A+ + ++ +EV+R Sbjct: 332 VAHSYTMENIMEVIR 346 Score = 57.0 bits (136), Expect = 5e-08 Identities = 33/98 (33%), Positives = 48/98 (48%), Gaps = 4/98 (4%) Query: 351 GCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLAL 410 G G+ +L+ GG + +R D V Y+P TD+W+ V PL R + + L Sbjct: 639 GVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLL 698 Query: 411 DGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444 LYAVGG L ++E YDP+ + W +A L G Sbjct: 699 GDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIG 736 >gi|31542246 kelch-like 36 [Homo sapiens] Length = 616 Score = 81.6 bits (200), Expect = 2e-15 Identities = 78/245 (31%), Positives = 109/245 (44%), Gaps = 28/245 (11%) Query: 332 AAAGEWRELTRLPEGAPARGCGLCV--LYNYLFVAGGVAPAGPDGRARPSDQVFCYNPAT 389 A + +W + T LP AR CV L ++F+AGG G A S+ ++ Y+P Sbjct: 320 AKSEQWVKETPLP----ARRSHHCVAVLGGFIFIAGGSFSRDNGGDAA-SNLLYRYDPRC 374 Query: 390 DSWSAVRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAPLPRGA 445 W V + Q R L +++ L A+GG L SVE Y P+ D W+ VA LPR Sbjct: 375 KQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPR-- 432 Query: 446 FAVAHEATTCHGEIYVSGGSLF----YR--LLKYDPRRDEWQECPCSSSRERSADMVALD 499 F H T +Y+SGG + YR LL YD R D W+E ++ M +L Sbjct: 433 FTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLG 492 Query: 500 GFIYRFDLSGSRGEAQAAGPSGV-SVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAAL 558 IY + GS ++ V V Y QW+ VAPL +G+ A Sbjct: 493 DSIY--SIGGSDDNIESMERFDVLGVEAYSPQCNQWTR-VAPLLHANSESGV-----AVW 544 Query: 559 DGAIY 563 +G IY Sbjct: 545 EGRIY 549 Score = 50.8 bits (120), Expect = 4e-06 Identities = 33/115 (28%), Positives = 51/115 (44%), Gaps = 18/115 (15%) Query: 382 VFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE----------CLLSVERYDPR 431 + CY+ TD W RP+ AR + +L +Y++GG +L VE Y P+ Sbjct: 463 LLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQ 522 Query: 432 ADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG-----SLFYRLLK-YDPRRDEW 480 ++W VAPL G IY+ GG + F + ++ YD D+W Sbjct: 523 CNQWTRVAPLLHANSESG--VAVWEGRIYILGGYSWENTAFSKTVQVYDREADKW 575 Score = 40.4 bits (93), Expect = 0.005 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 6/68 (8%) Query: 382 VFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECL------LSVERYDPRADRW 435 V Y+P + W+ V PL A S+ + +G +Y +GG +V+ YD AD+W Sbjct: 516 VEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKW 575 Query: 436 APVAPLPR 443 + LP+ Sbjct: 576 SRGVDLPK 583 >gi|158508542 kelch-like 33 [Homo sapiens] Length = 453 Score = 80.9 bits (198), Expect = 3e-15 Identities = 68/219 (31%), Positives = 95/219 (43%), Gaps = 23/219 (10%) Query: 336 EWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAV 395 EW +L LP R + + L+V GG + + P+ + W + Sbjct: 169 EWGQLPALPAPGRFRHGAASLAGSELYVCGG---QDFYSHSNTLASTLRWEPSQEDWEEM 225 Query: 396 RPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAPLPRGAFAVAHE 451 PL QARS L+ALDG LYA+GG L SVE Y+P + W P LP F AH Sbjct: 226 APLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCF--AHA 283 Query: 452 ATTCHGEIYVSG-----GSLFYRLLKYDPRRDEWQECPCSSSRERSAD-MVALDGFIYRF 505 A G++YVSG G L+ YDP+ ++ R+ M AL G +Y Sbjct: 284 AAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVPRAGHVMAALGGRLY-- 341 Query: 506 DLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLP 544 ++G GE + +S Y W+ +APL P Sbjct: 342 -VAGGLGETEDL----LSFEAYELRTDSWTH-LAPLPSP 374 Score = 38.9 bits (89), Expect = 0.014 Identities = 30/106 (28%), Positives = 39/106 (36%), Gaps = 12/106 (11%) Query: 344 PEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARS 403 P G P G + L L+VAGG+ G Y TDSW+ + PL Sbjct: 323 PMGVPRAGHVMAALGGRLYVAGGL------GETEDLLSFEAYELRTDSWTHLAPLPSPHV 376 Query: 404 QLRLLALDGHLYAVGGECLLS------VERYDPRADRWAPVAPLPR 443 L G L +GG + + Y P RW + LPR Sbjct: 377 GAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWLCLGTLPR 422 >gi|8922854 kelch-like 26 [Homo sapiens] Length = 615 Score = 80.9 bits (198), Expect = 3e-15 Identities = 82/270 (30%), Positives = 117/270 (43%), Gaps = 27/270 (10%) Query: 314 SPSGDADARGDAAVYCF-HAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGP 372 +P D+D + VY A +RELT + G + C + VL N+++VAGG Sbjct: 317 TPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGC-SHTC-VAVLDNFVYVAGGQHLQYR 374 Query: 373 DGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERY 428 G D + Y+P + W ++ ++++R Q +L L G +YA GG L SVERY Sbjct: 375 SGEGAV-DACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERY 433 Query: 429 DPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLF-----YRLLKYDPRRDEWQ-E 482 PR + W L R + H G +Y+SGG L YDP D+W+ + Sbjct: 434 CPRRNEWGYACSLKRRTW--GHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFK 491 Query: 483 CPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLR 542 P S R A MV G IY G R + ++V Y QW+ V+P+R Sbjct: 492 APMSEPRVLHA-MVGAGGRIYAL---GGRMDHVDRCFDVLAVEYYVPETDQWT-SVSPMR 546 Query: 543 LPGGPTGLQPFRCAALDGAIYCVSRAGTWR 572 G C L+ IY V WR Sbjct: 547 AGQSEAG-----CCLLERKIYIVG-GYNWR 570 Score = 64.7 bits (156), Expect = 2e-10 Identities = 44/136 (32%), Positives = 69/136 (50%), Gaps = 8/136 (5%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYS 193 D+VL ++ AHK VLAA SDYFRA AS+DV+ ++GVS LR ++ AYS Sbjct: 64 DVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYS 123 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 + + D V +V+ A LQ+ + + + +S+ C + A L LR+ Sbjct: 124 AEVT-LDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRE 182 Query: 254 AAYCFMSDHYLEVLRE 269 + F H+L++ E Sbjct: 183 SVDAFTFRHFLQIAEE 198 Score = 41.2 bits (95), Expect = 0.003 Identities = 41/161 (25%), Positives = 62/161 (38%), Gaps = 23/161 (14%) Query: 302 GPAGERAGSRPQSPSGDADARGDA-AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY 360 G AG +G R G + D A++C+ A +W + P P VL+ Sbjct: 452 GHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWE--FKAPMSEPR------VLHAM 503 Query: 361 LFVAGGVAPAGPDGRARPSDQVF------CYNPATDSWSAVRPLRQARSQLRLLALDGHL 414 + G + G GR D+ F Y P TD W++V P+R +S+ L+ + Sbjct: 504 VGAGGRIYALG--GRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKI 561 Query: 415 YAVGG------ECLLSVERYDPRADRWAPVAPLPRGAFAVA 449 Y VGG V+ Y+ D W P +A Sbjct: 562 YIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIA 602 >gi|24432026 kelch-like [Homo sapiens] Length = 634 Score = 80.1 bits (196), Expect = 6e-15 Identities = 73/241 (30%), Positives = 105/241 (43%), Gaps = 31/241 (12%) Query: 335 GEWRELTRLPEGAPARGC-GLCVLYNYLFVAGGVAPAGPDGRA---RPSDQVFCYNPATD 390 GEW+ T AP G+ VL N++++ GG D R + + Y+P + Sbjct: 326 GEWKHFTA--SLAPRMSNQGIAVLNNFVYLIGG------DNNVQGFRAESRCWRYDPRHN 377 Query: 391 SWSAVRPLRQARSQLRLLALDGHLYAVGGEC----LLSVERYDPRADRWAPVAPLPRGAF 446 W ++ L+Q + L + + ++YAV G L +VERYDP + WA VAPL R + Sbjct: 378 RWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVY 437 Query: 447 AVAHEATTCHGEIYVSGGSLFYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGFI 502 AH T G++Y++ G LK YDP + W R M L + Sbjct: 438 --AHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKL 495 Query: 503 YRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAI 562 Y + GS +A V+ Y C + QWS V PL G G+ A LD I Sbjct: 496 Y--VIGGSNNDA-GYRRDVHQVACYSCTSGQWS-SVCPLPAGHGEPGI-----AVLDNRI 546 Query: 563 Y 563 Y Sbjct: 547 Y 547 Score = 46.6 bits (109), Expect = 7e-05 Identities = 35/135 (25%), Positives = 62/135 (45%), Gaps = 8/135 (5%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYS 193 D+VL V GR + AH+ +LAA DYFR ++ + + GVS A+ +L Y+ Sbjct: 51 DVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYT 110 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 + + NV E + A +LQ+P D + + N +V A+ L+ L + Sbjct: 111 SELE-LSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTE 169 Query: 254 AAYCFMSDHYLEVLR 268 ++ +++ R Sbjct: 170 QLDTYILKNFVAFSR 184 Score = 45.4 bits (106), Expect = 2e-04 Identities = 33/116 (28%), Positives = 45/116 (38%), Gaps = 14/116 (12%) Query: 328 YCFHAAAGEWRELTRLPEGAPARGC--GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385 +C+ + W L P R G+ L N L+V GG G R QV CY Sbjct: 464 HCYDPGSNTWHTLA----DGPVRRAWHGMATLLNKLYVIGG--SNNDAGYRRDVHQVACY 517 Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVER------YDPRADRW 435 + + WS+V PL + + LD +Y +GG R YD D W Sbjct: 518 SCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCW 573 Score = 32.3 bits (72), Expect = 1.3 Identities = 23/78 (29%), Positives = 34/78 (43%), Gaps = 7/78 (8%) Query: 316 SGDADARGDA-AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDG 374 + DA R D V C+ +G+W + LP G G+ VL N ++V GG + Sbjct: 502 NNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEP--GIAVLDNRIYVLGGRS----HN 555 Query: 375 RARPSDQVFCYNPATDSW 392 R + V Y+ D W Sbjct: 556 RGSRTGYVHIYDVEKDCW 573 >gi|156616301 kelch-like 32 [Homo sapiens] Length = 620 Score = 79.7 bits (195), Expect = 7e-15 Identities = 70/254 (27%), Positives = 108/254 (42%), Gaps = 22/254 (8%) Query: 332 AAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDS 391 AA W EL +P G + C + V+ ++LFVAGG GR Y+P ++S Sbjct: 321 AAIANWSELAPMPVGR-SHHC-VAVMGDFLFVAGGEVEHA-SGRTCAVRTACRYDPRSNS 377 Query: 392 WSAVRPLRQARSQLRLLALDGHLYAVGG-----ECLLSVERYDPRADRWAPVAPLPRGAF 446 W+ + P++ R L A++ +LYAVGG + L +VERY P+ ++W V R Sbjct: 378 WAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRS-- 435 Query: 447 AVAHEATTCHGEIYVSGG-----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGF 501 H G +++SGG RL+ Y+P +++W R M A+ Sbjct: 436 LSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRK 495 Query: 502 IYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGA 561 +Y L G+ + + Y+ QW+ C L TG A +G Sbjct: 496 LY--VLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLL-----TGQNESGVAVHNGR 548 Query: 562 IYCVSRAGTWRFQP 575 IY V W +P Sbjct: 549 IYLVGGYSIWTNEP 562 Score = 53.1 bits (126), Expect = 7e-07 Identities = 40/135 (29%), Positives = 64/135 (47%), Gaps = 8/135 (5%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSLTALRLLLADAYS 193 D+ L ++ AHKAVLAA SDYFRA + D + + GV+ L+ L AY+ Sbjct: 43 DITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGADEVNLHGVTSLGLKQALEFAYT 102 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 G++ + P + +V+A LQL + + +L+ N ++ A L L Sbjct: 103 GQIL-LEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEK 161 Query: 254 AAYCFMSDHYLEVLR 268 A F+ H E+L+ Sbjct: 162 AVIDFLVKHLSELLK 176 Score = 40.4 bits (93), Expect = 0.005 Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 20/119 (16%) Query: 378 PSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE---------CLLSVERY 428 P DQ A +WS + P+ RS + + L+ GGE + + RY Sbjct: 312 PVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRY 371 Query: 429 DPRADRWAPVAPLP--RGAFAVAHEATTCHGEIYVSGGSLFYRLL-----KYDPRRDEW 480 DPR++ WA +AP+ R F + +Y GG R + +Y P++++W Sbjct: 372 DPRSNSWAEIAPMKNCREHFVLG----AMEEYLYAVGGRNELRQVLPTVERYCPKKNKW 426 >gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo sapiens] Length = 634 Score = 79.0 bits (193), Expect = 1e-14 Identities = 73/248 (29%), Positives = 106/248 (42%), Gaps = 32/248 (12%) Query: 337 WRELTRLPEGAPARGCGLCV--LYNYLFVAGGVAPAGPDGRARPSDQVFC-YNPATDSWS 393 W +LT +P A+ CV + +L+VAGG +A+ + FC Y+P ++W Sbjct: 345 WSKLTEMP----AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWI 400 Query: 394 AVRPLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAPLPRGAFAVA 449 + + Q R+ L +G +YA GG L S+E Y P ++W P PL Sbjct: 401 HLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLE--VARCC 458 Query: 450 HEATTCHGEIYVSGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRF 505 H + G + V+GG + + YDP D WQE P S+ V L +Y Sbjct: 459 HASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVM 518 Query: 506 DLS--GSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIY 563 S G RGE ++V Y QWS APL++ G+ +AL G Y Sbjct: 519 GGSQLGPRGERVDV----LTVECYSPATGQWS-YAAPLQV-----GVSTAGVSALHGRAY 568 Query: 564 CVSRAGTW 571 V G W Sbjct: 569 LV---GGW 573 Score = 52.4 bits (124), Expect = 1e-06 Identities = 51/185 (27%), Positives = 78/185 (42%), Gaps = 30/185 (16%) Query: 316 SGDADARGD-AAVYCFHAAAGEWRELTRLPEGAPARGC-GLCVLYNYLFVAGG-VAPAGP 372 +G +A G A++ C+ + +W+ T L AR C V + V GG +A A Sbjct: 424 AGGRNAEGSLASLECYVPSTNQWQPKTPLEV---ARCCHASAVADGRVLVTGGYIANAY- 479 Query: 373 DGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECL---------L 423 S V Y+PA+DSW + L R + L +Y +GG L L Sbjct: 480 ------SRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVL 533 Query: 424 SVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG-----SLFYRLLK-YDPRR 477 +VE Y P +W+ APL G + HG Y+ GG + + ++ + P Sbjct: 534 TVECYSPATGQWSYAAPLQVGVSTAG--VSALHGRAYLVGGWNEGEKKYKKCIQCFSPEL 591 Query: 478 DEWQE 482 +EW E Sbjct: 592 NEWTE 596 Score = 51.6 bits (122), Expect = 2e-06 Identities = 35/129 (27%), Positives = 68/129 (52%), Gaps = 5/129 (3%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRD--VLRVQ--GVSLTALRLLLADAYSGRM 196 DLV+ + HK+V+A+ S+YF +D + RV +S L ++A AY+G++ Sbjct: 74 DLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQRVDLNDISPLGLATVIAYAYTGKL 133 Query: 197 AGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAY 256 + + +++ A LQ+ + +D + ++S+ NC V++ A+ L + AA Sbjct: 134 T-LSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQ 192 Query: 257 CFMSDHYLE 265 F+ D++LE Sbjct: 193 KFIRDNFLE 201 Score = 50.8 bits (120), Expect = 4e-06 Identities = 39/131 (29%), Positives = 57/131 (43%), Gaps = 11/131 (8%) Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCV-LYNYLFVAGGVAPAGPDGRARPSDQVFC 384 +V + A+ W+EL L + RG V L + ++V GG + GP G V C Sbjct: 482 SVCAYDPASDSWQELPNL---STPRGWHCAVTLSDRVYVMGG-SQLGPRGERVDVLTVEC 537 Query: 385 YNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG------ECLLSVERYDPRADRWAPV 438 Y+PAT WS PL+ S + AL G Y VGG + ++ + P + W Sbjct: 538 YSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTED 597 Query: 439 APLPRGAFAVA 449 LP V+ Sbjct: 598 DELPEATVGVS 608 >gi|40018614 DRE1 protein [Homo sapiens] Length = 600 Score = 79.0 bits (193), Expect = 1e-14 Identities = 57/184 (30%), Positives = 85/184 (46%), Gaps = 21/184 (11%) Query: 329 CFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPA 388 C+ GEW+ L +LPE + +C L N + V+GG R D V+ YN Sbjct: 334 CYDPVTGEWKSLAKLPEFTKSE-YAVCALRNDILVSGG--------RINSRD-VWIYNSQ 383 Query: 389 TDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444 + W V L + R + ++ L G +Y VGG L SVE YD ++RW VAPL Sbjct: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEA 443 Query: 445 AFAVAHEATTCHGEIYVSGG-----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALD 499 + A T+C G+++V GG + ++ YDP + W +R V+L+ Sbjct: 444 VSSPA--VTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLN 501 Query: 500 GFIY 503 IY Sbjct: 502 NLIY 505 Score = 57.0 bits (136), Expect = 5e-08 Identities = 42/142 (29%), Positives = 67/142 (47%), Gaps = 14/142 (9%) Query: 325 AAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFC 384 ++V C+ + + W E+ L E + CV LFV GG GPD SD+V Sbjct: 422 SSVECYDSFSNRWTEVAPLKEAVSSPAVTSCV--GKLFVIGG----GPDDNT-CSDKVQS 474 Query: 385 YNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRG 444 Y+P T+SW + A+ + ++L+ +Y GG ++ YDP D W V + Sbjct: 475 YDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-LTKAIYCYDPVEDYWMHV----QN 529 Query: 445 AFAVAHEA--TTCHGEIYVSGG 464 F+ + C+G+IY+ GG Sbjct: 530 TFSRQENCGMSVCNGKIYILGG 551 Score = 52.4 bits (124), Expect = 1e-06 Identities = 86/380 (22%), Positives = 137/380 (36%), Gaps = 48/380 (12%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA------RASRDVL-RVQGVSLTALRLLLADAYS 193 D+++ V G+ H+AVL+A S YFRA R SR++L + G+ A+ L Y+ Sbjct: 67 DVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYT 126 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 G++ + +NV + + Q+ + QL NC + A L L Sbjct: 127 GKVK-ITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFT 185 Query: 254 AAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGS--R 311 F + +V + D + L G+ ++ A+ RA R Sbjct: 186 KCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRR 245 Query: 312 P--------------------QSPSGDADARGDAAVYCFHAAAGEWREL---TRLPEGAP 348 P Q+ D + Y A + L P P Sbjct: 246 PLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRP 305 Query: 349 ARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQ-ARSQLRL 407 R G + V GG G G P + CY+P T W ++ L + +S+ + Sbjct: 306 RRSTGYS---EVIVVVGGCERVG--GFNLPYTE--CYDPVTGEWKSLAKLPEFTKSEYAV 358 Query: 408 LALDGHLYAVGGEC-LLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSL 466 AL + GG V Y+ + + W VA L +G + H+ G++YV GG Sbjct: 359 CALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRW--RHKMAVLLGKVYVVGGYD 416 Query: 467 FYRLLK----YDPRRDEWQE 482 L YD + W E Sbjct: 417 GQNRLSSVECYDSFSNRWTE 436 Score = 33.1 bits (74), Expect = 0.78 Identities = 38/148 (25%), Positives = 62/148 (41%), Gaps = 16/148 (10%) Query: 399 RQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLP---RGAFAVAHEATTC 455 R++ ++ + G VGG L E YDP W +A LP + +AV Sbjct: 306 RRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVC----AL 361 Query: 456 HGEIYVSGGSLFYR-LLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEA 514 +I VSGG + R + Y+ + + W + M L G +Y + G G+ Sbjct: 362 RNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVY--VVGGYDGQN 419 Query: 515 QAAGPSGVSVSRYHCLAKQWSPCVAPLR 542 + + SV Y + +W+ VAPL+ Sbjct: 420 RLS-----SVECYDSFSNRWTE-VAPLK 441 Score = 31.2 bits (69), Expect = 3.0 Identities = 16/64 (25%), Positives = 27/64 (42%), Gaps = 7/64 (10%) Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385 A+YC+ W + + CG+ V +++ GG G +D + CY Sbjct: 513 AIYCYDPVEDYWMHVQNT--FSRQENCGMSVCNGKIYILGGRRENG-----EATDTILCY 565 Query: 386 NPAT 389 +PAT Sbjct: 566 DPAT 569 >gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] Length = 694 Score = 78.2 bits (191), Expect = 2e-14 Identities = 95/434 (21%), Positives = 168/434 (38%), Gaps = 63/434 (14%) Query: 155 KAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYSGRMAGVRPDNVAEV 207 + VL++ SDYF A + DV ++++GV +L L+ AY+GR+ ++ DN+ + Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLE-LKEDNIECL 232 Query: 208 VAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLEVL 267 ++ A LQL + + QL +NC + S A Q +L A+ + +H++EV+ Sbjct: 233 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI 292 Query: 268 R--------------------------EPAVFGRLSGAERDLLLRRR-LRAGRAHLLAAA 300 R E + L+ DL RR+ L A++ Sbjct: 293 RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPL 352 Query: 301 LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY 360 L P D + + + E R + + P P + Sbjct: 353 LAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKS-----TVGT 407 Query: 361 LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG- 419 LF GG+ + + + Y+ T+ W+ V + R Q + LD LY VGG Sbjct: 408 LFAVGGM------DSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR 461 Query: 420 ---ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGG----SLFYRLLK 472 + L +VE Y+P+ W+ + P+ + G +Y GG S + + Sbjct: 462 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLG--VAVLEGPMYAVGGHDGWSYLNTVER 519 Query: 473 YDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAK 532 +DP+ +W S+ + + L G +Y + G G + SV + Sbjct: 520 WDPQARQWNFVATMSTPRSTVGVAVLSGKLYA--VGGRDGSSCLK-----SVECFDPHTN 572 Query: 533 QWSPCVAPLRLPGG 546 +W+ C + GG Sbjct: 573 KWTLCAQMSKRRGG 586 Score = 77.0 bits (188), Expect = 5e-14 Identities = 55/161 (34%), Positives = 79/161 (49%), Gaps = 20/161 (12%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412 G+ VL + L+V GG DG + + V CYNP T +WS + P+ R L + L+G Sbjct: 447 GVAVLDDKLYVVGG-----RDG-LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEG 500 Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGGSL 466 +YAVGG L +VER+DP+A +W VA + PR VA G++Y GG Sbjct: 501 PMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVA----VLSGKLYAVGGRD 556 Query: 467 FYRLLK----YDPRRDEWQECPCSSSRERSADMVALDGFIY 503 LK +DP ++W C S R + +G +Y Sbjct: 557 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 597 Score = 60.5 bits (145), Expect = 5e-09 Identities = 40/123 (32%), Positives = 58/123 (47%), Gaps = 6/123 (4%) Query: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385 +V CF +W ++ + G G+ L+ GG + +R SD V Y Sbjct: 563 SVECFDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERY 620 Query: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPL 441 +P TD W+AV + +R + + L LYAVGG L +VE YDP+ + W VAPL Sbjct: 621 DPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 680 Query: 442 PRG 444 G Sbjct: 681 CLG 683 Score = 30.4 bits (67), Expect = 5.1 Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 6/51 (11%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARS 403 G+C+L + L+ GG DG+A + V Y+P T+ W+ V PL R+ Sbjct: 641 GVCLLGDKLYAVGGY-----DGQAY-LNTVEAYDPQTNEWTQVAPLCLGRA 685 >gi|128485503 kelch-like 30 [Homo sapiens] Length = 560 Score = 78.2 bits (191), Expect = 2e-14 Identities = 110/464 (23%), Positives = 170/464 (36%), Gaps = 60/464 (12%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSLTALRLLLADAYS 193 D+ L V GR L H+ +LA S YF A + D + ++ V + L+ Y+ Sbjct: 16 DVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAVVGQLVDFVYT 75 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVLSAAKRQRLNELRD 253 GR+ + NV + A RL P + + QL ANC + ++Q L + Sbjct: 76 GRLT-ITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGEQQGLLGVAA 134 Query: 254 AAYCFMSDHYLEVLREPAVF-----GRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERA 308 A+ F+ +++ V RE ++ DLL + ++ L+ RA Sbjct: 135 KAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRLEALMRWVRHDPQARA 194 Query: 309 GSRPQSPS---GDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCV---LYNYLF 362 P+ S DA R + E R G L + L L Sbjct: 195 AHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPLALQQKLEEVLV 254 Query: 363 VAGGVAPAGPDGRARPS---DQVFCYNPATDSWSAVRPLRQARS-QLRLLALDGHLYAVG 418 V GG A + P+ YN W A+ L AL+ ++Y G Sbjct: 255 VVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTG 314 Query: 419 GECLLSVERYDP--------RADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGGSLF- 467 G + + + W PVAP+ PR H + +GEIYV GG+ Sbjct: 315 GSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPR----TNHASAALNGEIYVIGGTTLD 370 Query: 468 -YRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPS-----G 521 + YDP D W P S + + ++ F +G RG G S Sbjct: 371 VVEVESYDPYTDSW--TPVSPALK----------YVSNFSAAGCRGRLYLVGSSACKYNA 418 Query: 522 VSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565 +++ Y+ + WS +P P L RCAAL G +Y + Sbjct: 419 LALQCYNPVTDAWSVIASPFL----PKYLSSPRCAALHGELYLI 458 Score = 44.3 bits (103), Expect = 3e-04 Identities = 36/110 (32%), Positives = 46/110 (41%), Gaps = 20/110 (18%) Query: 384 CYNPATDSWSAVRP--LRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPL 441 CYNP TD+WS + L + S R AL G LY + G+ V YDP A+ W V Sbjct: 423 CYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLI-GDNTKKVYVYDPGANLWQKVQSQ 481 Query: 442 ----PRGAFAVAHEATTCHGEIYVSG-------GSLFYRLLKYDPRRDEW 480 GA +A +YV+G G + YD RD W Sbjct: 482 HSLHENGALVPLGDA------LYVTGGRWQGMEGDYHVEMEAYDTVRDTW 525 Score = 33.5 bits (75), Expect = 0.60 Identities = 28/127 (22%), Positives = 47/127 (37%), Gaps = 22/127 (17%) Query: 326 AVYCFHAAAGEWRELTR--LPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVF 383 A+ C++ W + LP+ + C L+ L++ G + +V+ Sbjct: 420 ALQCYNPVTDAWSVIASPFLPKYLSSPRCA--ALHGELYLIGD-----------NTKKVY 466 Query: 384 CYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGG-------ECLLSVERYDPRADRWA 436 Y+P + W V+ L+ L LY GG + + +E YD D W Sbjct: 467 VYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWT 526 Query: 437 PVAPLPR 443 LPR Sbjct: 527 RHGALPR 533 >gi|55741643 kelch-like 14 [Homo sapiens] Length = 628 Score = 77.4 bits (189), Expect = 4e-14 Identities = 70/241 (29%), Positives = 105/241 (43%), Gaps = 29/241 (12%) Query: 337 WRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVR 396 W+ LT +P + A C + + N+LFV GG P+G+ ++ V Y+P +SW + Sbjct: 352 WKILTIMPYNS-AHHC-VVEVENFLFVLGGEDQWNPNGK-HSTNFVSRYDPRFNSWIQLP 408 Query: 397 PLRQARSQLRLLALDGHLYAVGGE----CLLSVERYDPRADRWAPVAPLPRGAFAVAHEA 452 P+++ R+ LD HLY +GG L SVE Y+ + W V+ LP+ AH Sbjct: 409 PMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQP--LAAHAG 466 Query: 453 TTCHGEIYVSG----GSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLS 508 +G+IY+SG G L YDP D W +++ + ++ +Y Sbjct: 467 AVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAI--- 523 Query: 509 GSRGEAQAAGPSGVSVSRYHCL---AKQWSPCVAP-LRLPGGPTGLQPFRCAALDGAIYC 564 G G S + V C QW+ P L GP CA LD +IY Sbjct: 524 ---GGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGP------GCAVLDDSIYL 574 Query: 565 V 565 V Sbjct: 575 V 575 Score = 57.8 bits (138), Expect = 3e-08 Identities = 45/171 (26%), Positives = 77/171 (45%), Gaps = 21/171 (12%) Query: 325 AAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFC 384 ++V C++ EWR ++ LP+ P V ++++GGV +G P ++C Sbjct: 439 SSVECYNLETNEWRYVSSLPQ--PLAAHAGAVHNGKIYISGGV----HNGEYVP--WLYC 490 Query: 385 YNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECL--------LSVERYDPRADRWA 436 Y+P D W+ + + R+ L ++ LYA+GG L + VE YDP+ D+W Sbjct: 491 YDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWN 550 Query: 437 PV-APLPRG----AFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQE 482 + P+ G AV ++ G S G+ + Y P + W E Sbjct: 551 ILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTE 601 Score = 30.8 bits (68), Expect = 3.9 Identities = 13/27 (48%), Positives = 18/27 (66%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRA 167 D+ L G++ HKAVLA+ S YFR+ Sbjct: 34 DVTLTAQGQQFHCHKAVLASCSQYFRS 60 >gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] Length = 720 Score = 75.5 bits (184), Expect = 1e-13 Identities = 63/212 (29%), Positives = 94/212 (44%), Gaps = 26/212 (12%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412 G+ V+ N L+V GG DG + + V C+NP W+ + P+ R L + L+G Sbjct: 470 GVAVIDNKLYVVGG-----RDG-LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 523 Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG-- 464 +YAVGG L +VER+DP +W VA + PR V + ++Y GG Sbjct: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV----VALNNKLYAIGGRD 579 Query: 465 --SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGV 522 S + +DP ++W C S R + +GF+Y + G + S + Sbjct: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY---VVGGHDAPASNHCSRL 636 Query: 523 S--VSRYHCLAKQWSPCVAPLRLPGGPTGLQP 552 S V RY WS VAPL +P + P Sbjct: 637 SDCVERYDPKGDSWS-TVAPLSVPRDAVAVCP 667 Score = 67.8 bits (164), Expect = 3e-11 Identities = 105/468 (22%), Positives = 180/468 (38%), Gaps = 71/468 (15%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVL-------RVQGVSLTALRLLLADAYS 193 D++L R+ AH+ VL+A SDYF A + DVL R++GV AL L+ AY+ Sbjct: 183 DVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYT 242 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLAN------------CYEVLS 241 G + ++ D + ++A A LQL ++ + QL +N C E+L+ Sbjct: 243 GVLQ-LKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLN 301 Query: 242 AAKRQRLNEL--------------RDAAYCFMSDHYLEVLREPAVFGRL-SGAERDLLLR 286 A + + + + SD + V E +F L D+ R Sbjct: 302 VAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDD-INVPDEETIFHALMQWVGHDVQNR 360 Query: 287 RRLRAGRAHLLAAALGPAGERAGSRPQSP-SGDADARGDAAVYCFHAAAGEWRELTRLPE 345 + + L P A S +GD + + + E R + + P Sbjct: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420 Query: 346 GAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQL 405 P + L+ GG+ + + + Y+ T+SW + + R Q Sbjct: 421 TKPRKST-----VGALYAVGGM------DAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469 Query: 406 RLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYV 461 + +D LY VGG + L +VE ++P W + P+ + T G +Y Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLG--VATLEGPMYA 527 Query: 462 SGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAA 517 GG S + ++DP +W S+ + +VAL+ +Y + G G + Sbjct: 528 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYA--IGGRDGSSCLK 585 Query: 518 GPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565 S+ + +WS C AP+ G G+ A +G +Y V Sbjct: 586 -----SMEYFDPHTNKWSLC-APMSKRRGGVGV-----ATYNGFLYVV 622 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/151 (32%), Positives = 70/151 (46%), Gaps = 26/151 (17%) Query: 348 PARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRL 407 P G+ L N L+ GG DG + + ++P T+ WS P+ + R + + Sbjct: 559 PRSTVGVVALNNKLYAIGG-----RDGSSCLKSMEY-FDPHTNKWSLCAPMSKRRGGVGV 612 Query: 408 LALDGHLYAVGGECLLS----------VERYDPRADRWAPVAPL--PRGAFAVAHEATTC 455 +G LY VGG + VERYDP+ D W+ VAPL PR A AV Sbjct: 613 ATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVC----PL 668 Query: 456 HGEIYVSGGSLFYRLLK----YDPRRDEWQE 482 ++YV GG + L YD +R+EW+E Sbjct: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699 >gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] Length = 718 Score = 75.5 bits (184), Expect = 1e-13 Identities = 63/212 (29%), Positives = 94/212 (44%), Gaps = 26/212 (12%) Query: 353 GLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDG 412 G+ V+ N L+V GG DG + + V C+NP W+ + P+ R L + L+G Sbjct: 470 GVAVIDNKLYVVGG-----RDG-LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 523 Query: 413 HLYAVGG----ECLLSVERYDPRADRWAPVAPL--PRGAFAVAHEATTCHGEIYVSGG-- 464 +YAVGG L +VER+DP +W VA + PR V + ++Y GG Sbjct: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV----VALNNKLYAIGGRD 579 Query: 465 --SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGV 522 S + +DP ++W C S R + +GF+Y + G + S + Sbjct: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLY---VVGGHDAPASNHCSRL 636 Query: 523 S--VSRYHCLAKQWSPCVAPLRLPGGPTGLQP 552 S V RY WS VAPL +P + P Sbjct: 637 SDCVERYDPKGDSWS-TVAPLSVPRDAVAVCP 667 Score = 67.8 bits (164), Expect = 3e-11 Identities = 105/468 (22%), Positives = 180/468 (38%), Gaps = 71/468 (15%) Query: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVL-------RVQGVSLTALRLLLADAYS 193 D++L R+ AH+ VL+A SDYF A + DVL R++GV AL L+ AY+ Sbjct: 183 DVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYT 242 Query: 194 GRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLAN------------CYEVLS 241 G + ++ D + ++A A LQL ++ + QL +N C E+L+ Sbjct: 243 GVLQ-LKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLN 301 Query: 242 AAKRQRLNEL--------------RDAAYCFMSDHYLEVLREPAVFGRL-SGAERDLLLR 286 A + + + + SD + V E +F L D+ R Sbjct: 302 VAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDD-INVPDEETIFHALMQWVGHDVQNR 360 Query: 287 RRLRAGRAHLLAAALGPAGERAGSRPQSP-SGDADARGDAAVYCFHAAAGEWRELTRLPE 345 + + L P A S +GD + + + E R + + P Sbjct: 361 QGELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPR 420 Query: 346 GAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQL 405 P + L+ GG+ + + + Y+ T+SW + + R Q Sbjct: 421 TKPRKST-----VGALYAVGGM------DAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469 Query: 406 RLLALDGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYV 461 + +D LY VGG + L +VE ++P W + P+ + T G +Y Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLG--VATLEGPMYA 527 Query: 462 SGG----SLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAA 517 GG S + ++DP +W S+ + +VAL+ +Y + G G + Sbjct: 528 VGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYA--IGGRDGSSCLK 585 Query: 518 GPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565 S+ + +WS C AP+ G G+ A +G +Y V Sbjct: 586 -----SMEYFDPHTNKWSLC-APMSKRRGGVGV-----ATYNGFLYVV 622 Score = 64.7 bits (156), Expect = 2e-10 Identities = 49/151 (32%), Positives = 70/151 (46%), Gaps = 26/151 (17%) Query: 348 PARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRL 407 P G+ L N L+ GG DG + + ++P T+ WS P+ + R + + Sbjct: 559 PRSTVGVVALNNKLYAIGG-----RDGSSCLKSMEY-FDPHTNKWSLCAPMSKRRGGVGV 612 Query: 408 LALDGHLYAVGGECLLS----------VERYDPRADRWAPVAPL--PRGAFAVAHEATTC 455 +G LY VGG + VERYDP+ D W+ VAPL PR A AV Sbjct: 613 ATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVC----PL 668 Query: 456 HGEIYVSGGSLFYRLLK----YDPRRDEWQE 482 ++YV GG + L YD +R+EW+E Sbjct: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699 Score = 54.7 bits (130), Expect = 3e-07 Identities = 34/98 (34%), Positives = 46/98 (46%), Gaps = 4/98 (4%) Query: 351 GCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLAL 410 G G+ +L+V GG + +R SD V Y+P DSWS V PL R + + L Sbjct: 609 GVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPL 668 Query: 411 DGHLYAVGG----ECLLSVERYDPRADRWAPVAPLPRG 444 LY VGG L +VE YD + + W P+ G Sbjct: 669 GDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIG 706 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.135 0.418 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 29,549,608 Number of Sequences: 37866 Number of extensions: 1721854 Number of successful extensions: 14372 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 212 Number of HSP's successfully gapped in prelim test: 875 Number of HSP's that attempted gapping in prelim test: 9959 Number of HSP's gapped (non-prelim): 4186 length of query: 623 length of database: 18,247,518 effective HSP length: 108 effective length of query: 515 effective length of database: 14,157,990 effective search space: 7291364850 effective search space used: 7291364850 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.