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Search of human proteins with 7657214
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
(714 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 1454 0.0
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 233 4e-61
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 228 1e-59
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 225 1e-58
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 224 2e-58
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 222 8e-58
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 222 8e-58
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 222 8e-58
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 222 8e-58
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 221 2e-57
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 221 2e-57
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 220 3e-57
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 203 4e-52
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 201 2e-51
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 199 6e-51
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 197 4e-50
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 196 5e-50
gi|116256471 SNF1-like kinase [Homo sapiens] 196 8e-50
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 193 4e-49
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 192 1e-48
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 191 2e-48
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 177 2e-44
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 176 9e-44
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 172 7e-43
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 172 7e-43
gi|156105707 SNF related kinase [Homo sapiens] 169 8e-42
gi|156105705 SNF related kinase [Homo sapiens] 169 8e-42
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 166 7e-41
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 166 9e-41
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 164 2e-40
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 1454 bits (3763), Expect = 0.0
Identities = 714/714 (100%), Positives = 714/714 (100%)
Query: 1 MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN 60
MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN
Sbjct: 1 MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGN 60
Query: 61 YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH 120
YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH
Sbjct: 61 YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH 120
Query: 121 PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA 180
PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA
Sbjct: 121 PNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRA 180
Query: 181 GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY 240
GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY
Sbjct: 181 GVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY 240
Query: 241 GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL 300
GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL
Sbjct: 241 GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSL 300
Query: 301 LEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS 360
LEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS
Sbjct: 301 LEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNS 360
Query: 361 DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA 420
DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA
Sbjct: 361 DVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEA 420
Query: 421 SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA 480
SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA
Sbjct: 421 SLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKA 480
Query: 481 LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP 540
LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP
Sbjct: 481 LLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQP 540
Query: 541 GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS 600
GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS
Sbjct: 541 GPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLS 600
Query: 601 PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR 660
PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR
Sbjct: 601 PGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSR 660
Query: 661 GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC 714
GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
Sbjct: 661 GRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC 714
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 233 bits (595), Expect = 4e-61
Identities = 131/355 (36%), Positives = 217/355 (61%), Gaps = 16/355 (4%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ HVLTG +VA+K+IDK + + + L R
Sbjct: 52 DEQPH--IGNYRL-QKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSL--QKLFR 106
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YLVME GG + + R++E EAR RQ+
Sbjct: 107 EVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 166
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + D F CGSP YA
Sbjct: 167 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTF---CGSPPYA 223
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 280
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ LL +P+KR +++Q + +RW+N + + T P+ D + + +
Sbjct: 281 STDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPD----PDFNDTKRI 336
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR 404
+ +G+ ++ + +++ + ++A Y LL +K + G+S +LC ++R
Sbjct: 337 DIMVTMGFARDEINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSR 391
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 228 bits (582), Expect = 1e-59
Identities = 136/378 (35%), Positives = 211/378 (55%), Gaps = 19/378 (5%)
Query: 15 APGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDF-----QHHKRVGNYLIGSRKLG 69
APG ++ + P+W S R R+ + VGNY + R +G
Sbjct: 8 APGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRL-LRTIG 66
Query: 70 EGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDI 129
+G+FAKV+ H+LTG +VAIK+IDK + + + L RE +I + + HPNI +L ++
Sbjct: 67 KGNFAKVKLARHILTGREVAIKIIDKTQLNPSSL--QKLFREVRIMKGLNHPNIVKLFEV 124
Query: 130 LETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKI 189
+ETE + YLVME G + + R++E EAR RQ++SAV + H+ +VHRDLK
Sbjct: 125 IETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKA 184
Query: 190 ENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GPKIDVWS 248
ENLLLD + NIK+ DFG SN + D F CGSP YAAPEL KKY GP++D+WS
Sbjct: 185 ENLLLDAEANIKIADFGFSNEFTLGSKLDTF---CGSPPYAAPELFQGKKYDGPEVDIWS 241
Query: 249 IGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKR 308
+GV +Y +++G+LPF + +L+ L ++++ + +P +ST S LR L +P KR
Sbjct: 242 LGVILYTLVSGSLPF--DGHNLKELRERVLRGKYR-VPFYMSTDCESILRRFLVLNPAKR 298
Query: 309 PNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLS 368
++Q + ++W+N Y G+ T P ED + + + +GY ++ ++ S
Sbjct: 299 CTLEQIMKDKWINIGYEGEELKPYTEPE----EDFGDTKRIEVMVGMGYTREEIKESLTS 354
Query: 369 NRACHILAIYFLLNKKLE 386
+ + A Y LL +K E
Sbjct: 355 QKYNEVTATYLLLGRKTE 372
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 225 bits (573), Expect = 1e-58
Identities = 179/621 (28%), Positives = 288/621 (46%), Gaps = 91/621 (14%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG++VA+K+IDK + + + L R
Sbjct: 12 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 66
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YLVME GG + + R++E EAR RQ+
Sbjct: 67 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 126
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + + T CGSP YA
Sbjct: 127 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 183
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 184 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 240
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P KR ++Q + +RW+N + + P L D
Sbjct: 241 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 296
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR-LYQI 408
+ +GY ++ ++++ R ++A Y LL K L G D++ K R +
Sbjct: 297 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSE-LEG-----DTITLKPRPSADL 350
Query: 409 EKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFL--HRPFSKKLDKNLPSHKQ 466
AP S++ + K+ + ++ G + +SKK N +K+
Sbjct: 351 TNSSAPSPSHKVQRSV--------SANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKR 402
Query: 467 PSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPP 526
P +DR++ + ASS+ + P P
Sbjct: 403 PE--------------EDRESGRK-----------------------ASSTAKVPASPLP 425
Query: 527 RTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSP 586
R P P ST + +L+ ++ S + L P
Sbjct: 426 GLERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQA----------SIQNGKDSLTMP 475
Query: 587 VSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNG 646
S A S+ +S P + +HP S PP E C P PS
Sbjct: 476 GSRASTASASAAVSAARPRQHQKSMSASVHPNKAS------GLPPTESN--CEVPRPSTA 527
Query: 647 PMQ-PLGSPNC--VKSRGRFP 664
P + P+ SP+ + S G P
Sbjct: 528 PQRVPVASPSAHNISSSGGAP 548
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 224 bits (571), Expect = 2e-58
Identities = 179/619 (28%), Positives = 286/619 (46%), Gaps = 86/619 (13%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG++VA+K+IDK + + + L R
Sbjct: 45 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YLVME GG + + R++E EAR RQ+
Sbjct: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + + T CGSP YA
Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P KR ++Q + +RW+N + + P L D
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR-LYQI 408
+ +GY ++ ++++ R ++A Y LL K L G D++ K R +
Sbjct: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSE-LEG-----DTITLKPRPSADL 383
Query: 409 EKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPS 468
AP S++ R + + Q + + +SKK N +K+P
Sbjct: 384 TNSSAPSPSHKVQ-----RSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPE 438
Query: 469 GSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRT 528
+DR++ + ASS+ + P P
Sbjct: 439 --------------EDRESGRK-----------------------ASSTAKVPASPLPGL 461
Query: 529 PRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVS 588
R P P ST + +L+ ++ S + L P S
Sbjct: 462 ERKKTTPTPSTNSVLSTSTNRSRNSPLLERASLGQA----------SIQNGKDSLTMPGS 511
Query: 589 LARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPM 648
A S+ +S P + +HP S PP E C P PS P
Sbjct: 512 RASTASASAAVSAARPRQHQKSMSASVHPNKAS------GLPPTESN--CEVPRPSTAPQ 563
Query: 649 Q-PLGSPNC--VKSRGRFP 664
+ P+ SP+ + S G P
Sbjct: 564 RVPVASPSAHNISSSGGAP 582
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 222 bits (566), Expect = 8e-58
Identities = 160/509 (31%), Positives = 257/509 (50%), Gaps = 65/509 (12%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG +VAIK+IDK + + + L R
Sbjct: 48 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YL+ME GG + + R++E EAR RQ+
Sbjct: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + G D F CGSP YA
Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P+KR ++Q + +RW+N + P D+S +
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSL------CYKT 403
+ +GY ++ ++ + I A Y LL +K + SD+ +S +
Sbjct: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSE-VRPSSDLNNSTGQSPHHKVQR 391
Query: 404 RLYQIEKYRA---------------PKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDF 448
++ +K R PK S ++ D+ DL+ + +K G
Sbjct: 392 SVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADS---DLKEDGISSRKSSGSAVGGKG 448
Query: 449 LHRPFSKKLDKNLPSHKQPSGSLMTQIQN-TKALLKDRKASK---SSFPDKDSFGCRNIF 504
+ P+ ++ N KA + +RK S SS RN +
Sbjct: 449 I----------------APASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTY 492
Query: 505 ----RKTSDSNCVASSSMEFIPVPPPRTP 529
R T+D + V + E +P RTP
Sbjct: 493 VCSERTTADRHSVIQNGKENSTIPDQRTP 521
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 222 bits (566), Expect = 8e-58
Identities = 131/349 (37%), Positives = 205/349 (58%), Gaps = 21/349 (6%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG +VAIK+IDK + + + L R
Sbjct: 48 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YL+ME GG + + R++E EAR RQ+
Sbjct: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + G D F CGSP YA
Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P+KR ++Q + +RW+N + P D+S +
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDS 398
+ +GY ++ ++ + I A Y LL +K S + D DS
Sbjct: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK-----SSELDASDS 376
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 222 bits (566), Expect = 8e-58
Identities = 131/349 (37%), Positives = 205/349 (58%), Gaps = 21/349 (6%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG +VAIK+IDK + + + L R
Sbjct: 48 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YL+ME GG + + R++E EAR RQ+
Sbjct: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + G D F CGSP YA
Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P+KR ++Q + +RW+N + P D+S +
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDS 398
+ +GY ++ ++ + I A Y LL +K S + D DS
Sbjct: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK-----SSELDASDS 376
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 222 bits (566), Expect = 8e-58
Identities = 131/349 (37%), Positives = 205/349 (58%), Gaps = 21/349 (6%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG +VAIK+IDK + + + L R
Sbjct: 48 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSL--QKLFR 102
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YL+ME GG + + R++E EAR RQ+
Sbjct: 103 EVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQI 162
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + G D F CGSP YA
Sbjct: 163 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTF---CGSPPYA 219
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 220 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 276
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P+KR ++Q + +RW+N + P D+S +
Sbjct: 277 STDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPEL----DISDQKRI 332
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDS 398
+ +GY ++ ++ + I A Y LL +K S + D DS
Sbjct: 333 DIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRK-----SSELDASDS 376
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 221 bits (562), Expect = 2e-57
Identities = 141/421 (33%), Positives = 230/421 (54%), Gaps = 33/421 (7%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG++VA+K+IDK + + + L R
Sbjct: 45 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YLVME GG + + R++E EAR RQ+
Sbjct: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + + T CGSP YA
Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P KR ++Q + +RW+N + + P L D
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR-LYQI 408
+ +GY ++ ++++ R ++A Y LL K L G D++ K R +
Sbjct: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSE-LEG-----DTITLKPRPSADL 383
Query: 409 EKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFL--HRPFSKKLDKNLPSHKQ 466
AP S++ + K+ + ++ G + +SKK N +K+
Sbjct: 384 TNSSAPSPSHKVQRSV--------SANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKR 435
Query: 467 P 467
P
Sbjct: 436 P 436
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 221 bits (562), Expect = 2e-57
Identities = 141/421 (33%), Positives = 230/421 (54%), Gaps = 33/421 (7%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG++VA+K+IDK + + + L R
Sbjct: 45 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YLVME GG + + R++E EAR RQ+
Sbjct: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + + T CGSP YA
Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P KR ++Q + +RW+N + + P L D
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTR-LYQI 408
+ +GY ++ ++++ R ++A Y LL K L G D++ K R +
Sbjct: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSE-LEG-----DTITLKPRPSADL 383
Query: 409 EKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFL--HRPFSKKLDKNLPSHKQ 466
AP S++ + K+ + ++ G + +SKK N +K+
Sbjct: 384 TNSSAPSPSHKVQRSV--------SANPKQRRFSDQAGPAIPTSNSYSKKTQSNNAENKR 435
Query: 467 P 467
P
Sbjct: 436 P 436
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 220 bits (561), Expect = 3e-57
Identities = 125/335 (37%), Positives = 200/335 (59%), Gaps = 16/335 (4%)
Query: 51 DFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRR 110
D Q H +GNY + + +G+G+FAKV+ H+LTG++VA+K+IDK + + + L R
Sbjct: 45 DEQPH--IGNYRL-LKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSL--QKLFR 99
Query: 111 EGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQL 170
E +I +++ HPNI +L +++ETE + YLVME GG + + R++E EAR RQ+
Sbjct: 100 EVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQI 159
Query: 171 ISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYA 230
+SAV++ H+ +VHRDLK ENLLLD D NIK+ DFG SN + + T CGSP YA
Sbjct: 160 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSN---EFTFGNKLDTFCGSPPYA 216
Query: 231 APELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289
APEL KKY GP++DVWS+GV +Y +++G+LPF + +L+ L ++++ + +P +
Sbjct: 217 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQ--NLKELRERVLRGKYR-IPFYM 273
Query: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVL 349
ST + L+ L +P KR ++Q + +RW+N + + P L D
Sbjct: 274 STDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED----DELKPYVEPLPDYKDPRRT 329
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKK 384
+ +GY ++ ++++ R ++A Y LL K
Sbjct: 330 ELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYK 364
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 203 bits (517), Expect = 4e-52
Identities = 123/344 (35%), Positives = 201/344 (58%), Gaps = 22/344 (6%)
Query: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
++G+Y++G LG G+F KV+ G H LTG KVA+K++++++ + V K ++RE Q +
Sbjct: 12 KIGHYVLGDT-LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLK 69
Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
+ RHP+I +L ++ T +++VME GG L I + R+EE EARR +Q++SAV++
Sbjct: 70 LFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDY 129
Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
HR VVHRDLK EN+LLD N K+ DFGLSN ++ + T CGSP YAAPE+++
Sbjct: 130 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVIS 186
Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
+ Y GP++D+WS GV +YA+L GTLPF E + L++K + + +P L+ +
Sbjct: 187 GRLYAGPEVDIWSCGVILYALLCGTLPFDDE--HVPTLFKK-IRGGVFYIPEYLNRSVAT 243
Query: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKV-PCNVTYPNRISLEDLSPSVVLHMTEK 354
L +L+ DP+KR I+ + W ++ + P + +Y + + V + EK
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANV----IDDEAVKEVCEK 299
Query: 355 LGYKNSDVINTVLSNRACHILAIYF--------LLNKKLERYLS 390
S+V+N++ S LA+ + ++N+ E YL+
Sbjct: 300 FECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLA 343
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 201 bits (511), Expect = 2e-51
Identities = 109/268 (40%), Positives = 171/268 (63%), Gaps = 9/268 (3%)
Query: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
++G+Y++G LG G+F KV+ G H LTG KVA+K++++++ + V K +RRE Q +
Sbjct: 23 KIGHYILGDT-LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLK 80
Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
+ RHP+I +L ++ T + ++VME GG L I + RL+E E+RR +Q++S V++
Sbjct: 81 LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY 140
Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
HR VVHRDLK EN+LLD N K+ DFGLSN ++ + T CGSP YAAPE+++
Sbjct: 141 CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVIS 197
Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
+ Y GP++D+WS GV +YA+L GTLPF + + L++K+ D + P L+ IS
Sbjct: 198 GRLYAGPEVDIWSSGVILYALLCGTLPF--DDDHVPTLFKKICD-GIFYTPQYLNPSVIS 254
Query: 296 FLRSLLEPDPVKRPNIQQALANRWLNEN 323
L+ +L+ DP+KR I+ + W ++
Sbjct: 255 LLKHMLQVDPMKRATIKDIREHEWFKQD 282
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 199 bits (507), Expect = 6e-51
Identities = 125/341 (36%), Positives = 188/341 (55%), Gaps = 22/341 (6%)
Query: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
R+G Y I R +G+G+FA V+ H++T KVAIK+IDK + ++ K + RE QI +
Sbjct: 4 RIGYYEI-DRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENL--KKIFREVQIMK 60
Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
M+ HP+I +L ++ETE YLV E GG + + R+ E EARR +Q+++AV
Sbjct: 61 MLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYF 120
Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
H +VHRDLK ENLLLD + NIK+ DFG SN + T CGSP YAAPEL
Sbjct: 121 CHCRNIVHRDLKAENLLLDANLNIKIADFGFSN---LFTPGQLLKTWCGSPPYAAPELFE 177
Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPF---TVEPFSLRALYQKMVDKEMNPLPTQLSTG 292
K+Y GPK+D+WS+GV +Y ++ G LPF T++ R L K +P +ST
Sbjct: 178 GKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKF------RIPFFMSTE 231
Query: 293 AISFLRSLLEPDPVKRPNIQQALANRWL-----NENYTGKVPCNVTYPNRISLEDLSPSV 347
+R +L DP KR +++Q ++W+ + N+ + ++ L+ V
Sbjct: 232 CEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDV 291
Query: 348 VLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERY 388
+L M E +G + ++ S+ H AIY LL + +R+
Sbjct: 292 LLAM-EDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRH 331
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 197 bits (500), Expect = 4e-50
Identities = 131/368 (35%), Positives = 196/368 (53%), Gaps = 26/368 (7%)
Query: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
+G G FAKV+ H+LTGE VAIK++DK D ++ E + + +RH +I QL
Sbjct: 17 IGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDL---PRIKTEIEALKNLRHQHICQLY 73
Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
+LET N ++V+E CPGG L I + RL E E R RQ++SAV ++H G HRDL
Sbjct: 74 HVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDL 133
Query: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSD-PFSTQCGSPAYAAPELLARKKY-GPKID 245
K ENLL DE + +KLIDFGL CA G D T CGS AYAAPEL+ K Y G + D
Sbjct: 134 KPENLLFDEYHKLKLIDFGL--CAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEAD 191
Query: 246 VWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDP 305
VWS+G+ +Y ++ G LPF + ++ ALY+K++ + + +P LS +I L+ +L+ DP
Sbjct: 192 VWSMGILLYVLMCGFLPF--DDDNVMALYKKIMRGKYD-VPKWLSPSSILLLQQMLQVDP 248
Query: 306 VKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINT 365
KR +++ L + W+ ++Y V P +D + +H N +
Sbjct: 249 KKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHR-----NNRQTMED 303
Query: 366 VLSN-RACHILAIYFLLNKK----------LERYLSGKSDIQDSLCYKTRLYQIEKYRAP 414
++S + H+ A Y LL K L + G++ K+ + +E A
Sbjct: 304 LISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTAS 363
Query: 415 KESYEASL 422
++Y A L
Sbjct: 364 DKNYVAGL 371
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 196 bits (499), Expect = 5e-50
Identities = 127/341 (37%), Positives = 190/341 (55%), Gaps = 21/341 (6%)
Query: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
RVG Y I LG+G+FA V+ G H +T +VAIK+IDK + D + + RE QI +
Sbjct: 16 RVGFYDIEGT-LGKGNFAVVKLGRHRITKTEVAIKIIDKSQL--DAVNLEKIYREVQIMK 72
Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
M+ HP+I +L ++ET++ YLV E G + + RL ESEARR Q++SAV++
Sbjct: 73 MLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDY 132
Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
H +VHRDLK ENLLLD + NIK+ DFG N + +T CGSP YAAPE+
Sbjct: 133 CHGRKIVHRDLKAENLLLDNNMNIKIADFGFGN---FFKSGELLATWCGSPPYAAPEVFE 189
Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
++Y GP++D+WS+GV +Y ++ G LPF + +L L Q++++ +P +S
Sbjct: 190 GQQYEGPQLDIWSMGVVLYVLVCGALPF--DGPTLPILRQRVLEGRFR-IPYFMSEDCEH 246
Query: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSV------VL 349
+R +L DP KR I Q ++W+ + P V YP ++ PS+ VL
Sbjct: 247 LIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRP--VLYPQE---QENEPSIGEFNEQVL 301
Query: 350 HMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLS 390
+ LG I ++ + H AIYFLL ++L+ + S
Sbjct: 302 RLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRS 342
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 196 bits (497), Expect = 8e-50
Identities = 120/335 (35%), Positives = 187/335 (55%), Gaps = 12/335 (3%)
Query: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
RVG Y I R LG+G+FA V+ H +T +VAIK+IDK R D+ + + RE Q+ +
Sbjct: 23 RVGFYDI-ERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL--DSSNLEKIYREVQLMK 79
Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEH 176
++ HP+I +L ++ET++ Y+V E G + + L E+EAR+ Q++SAVE+
Sbjct: 80 LLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEY 139
Query: 177 LHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLA 236
H +VHRDLK ENLLLD + +IKL DFG N +P ST CGSP YAAPE+
Sbjct: 140 CHDHHIVHRDLKTENLLLDGNMDIKLADFGFGN---FYKSGEPLSTWCGSPPYAAPEVFE 196
Query: 237 RKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAIS 295
K+Y GP++D+WS+GV +Y ++ G+LPF + +L L Q++++ +P +S S
Sbjct: 197 GKEYEGPQLDIWSLGVVLYVLVCGSLPF--DGPNLPTLRQRVLEGRFR-IPFFMSQDCES 253
Query: 296 FLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLS--PSVVLHMTE 353
+R +L DP +R I Q +RW+ P + +L L + +
Sbjct: 254 LIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQ 313
Query: 354 KLGYKNSDVINTVLSNRACHILAIYFLLNKKLERY 388
LG + ++ ++ H AIY+LL ++L+ Y
Sbjct: 314 TLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEY 348
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 193 bits (491), Expect = 4e-49
Identities = 175/600 (29%), Positives = 268/600 (44%), Gaps = 88/600 (14%)
Query: 53 QHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREG 112
QH + VG Y + + LG+G V+ G+H +TG+KVAIK++++++ + V + RE
Sbjct: 26 QHAQYVGPYRL-EKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSES--VLMKVEREI 82
Query: 113 QIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLIS 172
I ++I HP++ +L D+ E + YLV+E GG L + +K RL EAR++ RQ++S
Sbjct: 83 AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVS 142
Query: 173 AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAP 232
A++ H + HRDLK ENLLLDE NNI++ DFG+ A + T CGSP YA P
Sbjct: 143 ALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGM---ASLQVGDSLLETSCGSPHYACP 199
Query: 233 ELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLST 291
E++ +KY G + D+WS GV ++A+L G LPF + +LR L +K V + + +P +
Sbjct: 200 EVIKGEKYDGRRADMWSCGVILFALLVGALPF--DDDNLRQLLEK-VKRGVFHMPHFIPP 256
Query: 292 GAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHM 351
S LR ++E +P KR +++Q + W PC P R V +
Sbjct: 257 DCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGR--------RVAMRS 308
Query: 352 TEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKY 411
G + DV+ + +++ C F ++L R L + + Q+ + Y L + E+Y
Sbjct: 309 LPSNGELDPDVLES-MASLGC------FRDRERLHRELRSEEENQEKMIYYLLLDRKERY 361
Query: 412 RAPKESYEASLDTWTRDLEFHAVQDKKPKEQ----EKRGDFLHRPFSKKLDKNLPSHKQP 467
+ ++ QD P+ KR D P + K P K
Sbjct: 362 PSCED------------------QDLPPRNDVDPPRKRVD---SPMLSRHGKRRPERKSM 400
Query: 468 SGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPR 527
+T + + R+A + + + S R S ++ SSS P+ PR
Sbjct: 401 EVLSITDAGGGGSPVPTRRALEMAQHSQRS-------RSVSGASTGLSSS----PLSSPR 449
Query: 528 TPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFES-VDRDDHVEVLSPSHHYRILNSP 586
+P PE PG G D R S + + P P
Sbjct: 450 SPVFSFSPE---PGAG-------------DEARGGGSPTSKTQTLPSRGPRGGGAGEQPP 493
Query: 587 VSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNG 646
AR T PG P S TPLH L H + SP G PPP P G
Sbjct: 494 PPSAR-----STPLPGPPGSPRSSGGTPLHSPL----HTPRASPTGTPG-TTPPPSPGGG 543
>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 2 [Homo sapiens]
Length = 574
Score = 192 bits (487), Expect = 1e-48
Identities = 109/283 (38%), Positives = 171/283 (60%), Gaps = 24/283 (8%)
Query: 57 RVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQ 116
++G+Y++G LG G+F KV+ G H LTG KVA+K++++++ + V K +RRE Q +
Sbjct: 23 KIGHYILGDT-LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLK 80
Query: 117 MIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEK---------------KRLEES 161
+ RHP+I +L ++ T + ++VME GG L I + K L+E
Sbjct: 81 LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEK 140
Query: 162 EARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFS 221
E+RR +Q++S V++ HR VVHRDLK EN+LLD N K+ DFGLSN ++ +
Sbjct: 141 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLR 197
Query: 222 TQCGSPAYAAPELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDK 280
T CGSP YAAPE+++ + Y GP++D+WS GV +YA+L GTLPF + + L++K+ D
Sbjct: 198 TSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF--DDDHVPTLFKKICD- 254
Query: 281 EMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNEN 323
+ P L+ IS L+ +L+ DP+KR I+ + W ++
Sbjct: 255 GIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 297
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 191 bits (485), Expect = 2e-48
Identities = 125/349 (35%), Positives = 195/349 (55%), Gaps = 16/349 (4%)
Query: 53 QHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREG 112
QH + VG Y + + LG+G V+ G+H +T +KVAIK++++++ + V + RE
Sbjct: 11 QHAQYVGPYRL-EKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSES--VLMKVEREI 67
Query: 113 QIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLIS 172
I ++I HP++ +L D+ E + YLV+E GG L + +K RL EAR++ RQ+IS
Sbjct: 68 AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIIS 127
Query: 173 AVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAP 232
A++ H + HRDLK ENLLLDE NNI++ DFG+ A + T CGSP YA P
Sbjct: 128 ALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGM---ASLQVGDSLLETSCGSPHYACP 184
Query: 233 ELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLST 291
E++ +KY G K DVWS GV ++A+L G LPF + +LR L +K V + + +P +
Sbjct: 185 EVIRGEKYDGRKADVWSCGVILFALLVGALPF--DDDNLRQLLEK-VKRGVFHMPHFIPP 241
Query: 292 GAISFLRSLLEPDPVKRPNIQQALANRWL----NENYTGK-VPCNVTYPNRISLEDLSPS 346
S LR ++E D +R ++ + W NE + +P V + SLED+ P
Sbjct: 242 DCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPD 301
Query: 347 VVLHMTEKLGYKN-SDVINTVLSNRACHILAIYFLLNKKLERYLSGKSD 394
V+ M +++ + ++ +LS IYFLL + ERY S + +
Sbjct: 302 VLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDE 350
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 177 bits (450), Expect = 2e-44
Identities = 116/317 (36%), Positives = 177/317 (55%), Gaps = 19/317 (5%)
Query: 16 PGGGGGAEDAARPAAACEGSFL-PAWVSGVPRERLRDFQHHKRVGNYLIGSRK-LGEGSF 73
P G GA + R A A + L P GV R HHK + ++ LG+G++
Sbjct: 13 PDLGLGAPGSPREAVAGATAALEPRKPHGVKRH------HHKHNLKHRYELQETLGKGTY 66
Query: 74 AKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETE 133
KV+ +G VAIK I K + K + + ++RRE +I + HP+I + ++ E +
Sbjct: 67 GKVKRATERFSGRVVAIKSIRKDKIKDEQDMV-HIRREIEIMSSLNHPHIISIYEVFENK 125
Query: 134 NSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLL 193
+ ++ME G L I E++RL E E R + RQ++SAV + H+ GVVHRDLK+EN+L
Sbjct: 126 DKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENIL 185
Query: 194 LDEDNNIKLIDFGLSNCAGILGYSDPF-STQCGSPAYAAPELLARKKY-GPKIDVWSIGV 251
LD++ NIK+ DFGLSN L D F T CGSP YA+PE++ + Y GP++D W++GV
Sbjct: 186 LDDNCNIKIADFGLSN----LYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGV 241
Query: 252 NMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNI 311
+Y ++ GT+PF + F + L +++ E PTQ S A +R +L +P +R I
Sbjct: 242 LLYTLVYGTMPF--DGFDHKNLIRQISSGEYRE-PTQPS-DARGLIRWMLMVNPDRRATI 297
Query: 312 QQALANRWLNENYTGKV 328
+ + W+N Y V
Sbjct: 298 EDIANHWWVNWGYKSSV 314
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 176 bits (445), Expect = 9e-44
Identities = 107/314 (34%), Positives = 169/314 (53%), Gaps = 22/314 (7%)
Query: 49 LRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNL 108
+R+ KR+G Y I ++G G+F++V+ G+H LT EKVAIK++DK K D + L
Sbjct: 62 VREITLGKRIGFYRIRG-EIGSGNFSQVKLGIHSLTKEKVAIKILDK--TKLDQKTQRLL 118
Query: 109 RREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIR 168
RE + + HPNI +L +++ET + +LVME GG L KI + +L E E++
Sbjct: 119 SREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFS 178
Query: 169 QLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPA 228
Q++SAV+H+H ++HRDLK EN+ + +K+ DFG S + + +T CGSP
Sbjct: 179 QIVSAVKHMHENQIIHRDLKAENVFYTSNTCVKVGDFGFST---VSKKGEMLNTFCGSPP 235
Query: 229 YAAPELLARKKY-GPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPT 287
YAAPEL + Y G +D+W++GV +Y M+TGT+PF E A +K + + +P
Sbjct: 236 YAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETV---AKLKKSILEGTYSVPP 292
Query: 288 QLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSV 347
+S +R +L+ P +R I + + W+ V YP + L P
Sbjct: 293 HVSEPCHRLIRGVLQQIPTERYGIDCIMNDEWMQ---------GVPYPTPLEPFQLDPK- 342
Query: 348 VLHMTEKLGYKNSD 361
H++E K +
Sbjct: 343 --HLSETSTLKEEE 354
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 172 bits (437), Expect = 7e-43
Identities = 107/259 (41%), Positives = 147/259 (56%), Gaps = 14/259 (5%)
Query: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
LG G+F++V TG+ A+K I KK K ++ E + + I+H NI L
Sbjct: 29 LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE---SSIENEIAVLRKIKHENIVALE 85
Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
DI E+ N YLVM+L GG L +I EK E +A IRQ++ AV +LHR G+VHRDL
Sbjct: 86 DIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDL 145
Query: 188 KIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKI 244
K ENLL DE++ I + DFGLS + G D ST CG+P Y APE+LA+K Y +
Sbjct: 146 KPENLLYYSQDEESKIMISDFGLSK---MEGKGDVMSTACGTPGYVAPEVLAQKPYSKAV 202
Query: 245 DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEM---NPLPTQLSTGAISFLRSLL 301
D WSIGV Y +L G PF E S L+++++ E +P +S A F+R+L+
Sbjct: 203 DCWSIGVIAYILLCGYPPFYDENDS--KLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
Query: 302 EPDPVKRPNIQQALANRWL 320
E DP KR +QA + W+
Sbjct: 261 EKDPNKRYTCEQAARHPWI 279
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 172 bits (437), Expect = 7e-43
Identities = 107/259 (41%), Positives = 147/259 (56%), Gaps = 14/259 (5%)
Query: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
LG G+F++V TG+ A+K I KK K ++ E + + I+H NI L
Sbjct: 29 LGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE---SSIENEIAVLRKIKHENIVALE 85
Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
DI E+ N YLVM+L GG L +I EK E +A IRQ++ AV +LHR G+VHRDL
Sbjct: 86 DIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDL 145
Query: 188 KIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKI 244
K ENLL DE++ I + DFGLS + G D ST CG+P Y APE+LA+K Y +
Sbjct: 146 KPENLLYYSQDEESKIMISDFGLSK---MEGKGDVMSTACGTPGYVAPEVLAQKPYSKAV 202
Query: 245 DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEM---NPLPTQLSTGAISFLRSLL 301
D WSIGV Y +L G PF E S L+++++ E +P +S A F+R+L+
Sbjct: 203 DCWSIGVIAYILLCGYPPFYDENDS--KLFEQILKAEYEFDSPYWDDISDSAKDFIRNLM 260
Query: 302 EPDPVKRPNIQQALANRWL 320
E DP KR +QA + W+
Sbjct: 261 EKDPNKRYTCEQAARHPWI 279
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 169 bits (428), Expect = 8e-42
Identities = 113/331 (34%), Positives = 181/331 (54%), Gaps = 21/331 (6%)
Query: 66 RKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQ 125
+ LG G FA V+ HV TGEKVA+KVIDK K DT T +L +E + ++++HPNI +
Sbjct: 20 KTLGRGHFAVVKLARHVFTGEKVAVKVIDK--TKLDTLATGHLFQEVRCMKLVQHPNIVR 77
Query: 126 LLDILETENSYYLVMELCPGGNLMHKIYE-KKRLEESEARRYIRQLISAVEHLHRAGVVH 184
L ++++T+ YL++EL GG++ I + ++ L E A++Y Q++ A+ + H+ VVH
Sbjct: 78 LYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVH 137
Query: 185 RDLKIENLLLDEDNN-IKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GP 242
RDLK EN++ E +KL DFG SN +T CGS AY+APE+L +Y P
Sbjct: 138 RDLKPENVVFFEKQGLVKLTDFGFSN---KFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194
Query: 243 KIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLE 302
+D+WS+GV ++ ++ G PF E L M K +P+ +S + +L+
Sbjct: 195 AVDIWSLGVILFMLVCGQPPFQ-EANDSETLTMIMDCK--YTVPSHVSKECKDLITRMLQ 251
Query: 303 PDPVKRPNIQQALANRWLNENYTGKVPCNVTYPN--RISLEDLSP----SVVLHMTEKLG 356
DP +R ++++ + WL G P T N +S ++LS S++ M
Sbjct: 252 RDPKRRASLEEIENHPWLQ----GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI 307
Query: 357 YKNSDVINTVLSNRACHILAIYFLLNKKLER 387
++ + +NR HI A YFLL +++ R
Sbjct: 308 ADRDAIVEALETNRYNHITATYFLLAERILR 338
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 169 bits (428), Expect = 8e-42
Identities = 113/331 (34%), Positives = 181/331 (54%), Gaps = 21/331 (6%)
Query: 66 RKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQ 125
+ LG G FA V+ HV TGEKVA+KVIDK K DT T +L +E + ++++HPNI +
Sbjct: 20 KTLGRGHFAVVKLARHVFTGEKVAVKVIDK--TKLDTLATGHLFQEVRCMKLVQHPNIVR 77
Query: 126 LLDILETENSYYLVMELCPGGNLMHKIYE-KKRLEESEARRYIRQLISAVEHLHRAGVVH 184
L ++++T+ YL++EL GG++ I + ++ L E A++Y Q++ A+ + H+ VVH
Sbjct: 78 LYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVH 137
Query: 185 RDLKIENLLLDEDNN-IKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKY-GP 242
RDLK EN++ E +KL DFG SN +T CGS AY+APE+L +Y P
Sbjct: 138 RDLKPENVVFFEKQGLVKLTDFGFSN---KFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194
Query: 243 KIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLE 302
+D+WS+GV ++ ++ G PF E L M K +P+ +S + +L+
Sbjct: 195 AVDIWSLGVILFMLVCGQPPFQ-EANDSETLTMIMDCK--YTVPSHVSKECKDLITRMLQ 251
Query: 303 PDPVKRPNIQQALANRWLNENYTGKVPCNVTYPN--RISLEDLSP----SVVLHMTEKLG 356
DP +R ++++ + WL G P T N +S ++LS S++ M
Sbjct: 252 RDPKRRASLEEIENHPWLQ----GVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDI 307
Query: 357 YKNSDVINTVLSNRACHILAIYFLLNKKLER 387
++ + +NR HI A YFLL +++ R
Sbjct: 308 ADRDAIVEALETNRYNHITATYFLLAERILR 338
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 166 bits (420), Expect = 7e-41
Identities = 104/262 (39%), Positives = 152/262 (58%), Gaps = 16/262 (6%)
Query: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
LG G+F++V LTG+ A+K I K A +D+ +L E + + I+H NI L
Sbjct: 29 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDS----SLENEIAVLKKIKHENIVTLE 84
Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
DI E+ YYLVM+L GG L +I E+ E +A I+Q++SAV++LH G+VHRDL
Sbjct: 85 DIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDL 144
Query: 188 KIENLLL---DEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKI 244
K ENLL +E++ I + DFGLS + + ST CG+P Y APE+LA+K Y +
Sbjct: 145 KPENLLYLTPEENSKIMITDFGLSK----MEQNGIMSTACGTPGYVAPEVLAQKPYSKAV 200
Query: 245 DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVD---KEMNPLPTQLSTGAISFLRSLL 301
D WSIGV Y +L G PF E S L++K+ + + +P +S A F+ LL
Sbjct: 201 DCWSIGVITYILLCGYPPFYEETES--KLFEKIKEGYYEFESPFWDDISESAKDFICHLL 258
Query: 302 EPDPVKRPNIQQALANRWLNEN 323
E DP +R ++AL++ W++ N
Sbjct: 259 EKDPNERYTCEKALSHPWIDGN 280
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 166 bits (419), Expect = 9e-41
Identities = 98/263 (37%), Positives = 155/263 (58%), Gaps = 12/263 (4%)
Query: 68 LGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLL 127
LG+G++ KV++ +G VAIK I K + K D ++RRE +I + HP+I +
Sbjct: 59 LGKGTYGKVKKARES-SGRLVAIKSIRKDKIK-DEQDLMHIRREIEIMSSLNHPHIIAIH 116
Query: 128 DILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDL 187
++ E + +VME G+L I E+++L E EAR + RQ++SAV + H+ VVHRDL
Sbjct: 117 EVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDL 176
Query: 188 KIENLLLDEDNNIKLIDFGLSNCAGILGYSDPF-STQCGSPAYAAPELLARKKY-GPKID 245
K+EN+LLD + NIK+ DFGLSN L + F T CGSP YA+PE++ K Y GP++D
Sbjct: 177 KLENILLDANGNIKIADFGLSN----LYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVD 232
Query: 246 VWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDP 305
WS+GV +Y ++ GT+PF + + L +++ + P + A +R LL +P
Sbjct: 233 SWSLGVLLYILVHGTMPF--DGHDHKILVKQISNGAYREPPK--PSDACGLIRWLLMVNP 288
Query: 306 VKRPNIQQALANRWLNENYTGKV 328
+R ++ ++ W+N Y +V
Sbjct: 289 TRRATLEDVASHWWVNWGYATRV 311
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 164 bits (416), Expect = 2e-40
Identities = 108/279 (38%), Positives = 162/279 (58%), Gaps = 16/279 (5%)
Query: 56 KRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQ 115
KR G YL+G LGEGS+AKV+ VAIK+ID+K+A D ++ K L RE +I
Sbjct: 8 KRRG-YLLGIN-LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPAD-FLEKFLPREIEIL 64
Query: 116 QMIRHPNITQLLDILETENS-YYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAV 174
M+ H +I + +I ET + Y+VMEL G+L+ I + L E EAR+ QL A+
Sbjct: 65 AMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAI 124
Query: 175 EHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLS-----NCAGILGYSDPFSTQCGSPAY 229
++ H VVHRDLK +NLLLD+D NIKL DF S + +G + S F CGSPAY
Sbjct: 125 KYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTF---CGSPAY 181
Query: 230 AAPELLARKKYGPKI-DVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMN-PLPT 287
AAPE+L Y PK+ D+WS+GV +Y M+ G++P+ + +++ + + + +N P
Sbjct: 182 AAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPY--DDSNIKKMLRIQKEHRVNFPRSK 239
Query: 288 QLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTG 326
L+ + +L+PD +R +I + L++ W+ G
Sbjct: 240 HLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARG 278
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,488,793
Number of Sequences: 37866
Number of extensions: 1709439
Number of successful extensions: 11176
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 722
Number of HSP's successfully gapped in prelim test: 221
Number of HSP's that attempted gapping in prelim test: 8200
Number of HSP's gapped (non-prelim): 1657
length of query: 714
length of database: 18,247,518
effective HSP length: 109
effective length of query: 605
effective length of database: 14,120,124
effective search space: 8542675020
effective search space used: 8542675020
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.