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Search of human proteins with 73747915
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
(703 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 1389 0.0
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 1277 0.0
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 479 e-135
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 479 e-135
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 444 e-124
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 419 e-117
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 322 7e-88
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 319 5e-87
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 245 1e-64
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 243 3e-64
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 243 3e-64
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 243 3e-64
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 233 3e-61
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 226 4e-59
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 200 3e-51
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 187 2e-47
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 167 3e-41
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 163 4e-40
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 161 2e-39
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 161 2e-39
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 159 6e-39
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 155 2e-37
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 154 3e-37
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 154 3e-37
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 154 3e-37
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 154 3e-37
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 154 3e-37
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 152 8e-37
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 148 2e-35
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 147 4e-35
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 1389 bits (3594), Expect = 0.0
Identities = 703/703 (100%), Positives = 703/703 (100%)
Query: 1 MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLG 60
MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLG
Sbjct: 1 MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLG 60
Query: 61 FVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLS 120
FVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLS
Sbjct: 61 FVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLS 120
Query: 121 PPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL 180
PPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL
Sbjct: 121 PPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL 180
Query: 181 GGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGF 240
GGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGF
Sbjct: 181 GGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGF 240
Query: 241 FQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHM 300
FQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHM
Sbjct: 241 FQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHM 300
Query: 301 PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE 360
PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE
Sbjct: 301 PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE 360
Query: 361 QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG 420
QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG
Sbjct: 361 QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG 420
Query: 421 SYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNR 480
SYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNR
Sbjct: 421 SYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNR 480
Query: 481 PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC 540
PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC
Sbjct: 481 PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC 540
Query: 541 YLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
YLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV
Sbjct: 541 YLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 601 GEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIA 660
GEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIA
Sbjct: 601 GEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIA 660
Query: 661 HRLQAVQRAHQILVLQEGKLQKLAQLQEGQDLYSRLVQQRLMD 703
HRLQAVQRAHQILVLQEGKLQKLAQLQEGQDLYSRLVQQRLMD
Sbjct: 661 HRLQAVQRAHQILVLQEGKLQKLAQLQEGQDLYSRLVQQRLMD 703
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 1277 bits (3305), Expect = 0.0
Identities = 645/648 (99%), Positives = 645/648 (99%)
Query: 1 MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLG 60
MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLG
Sbjct: 1 MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLG 60
Query: 61 FVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLS 120
FVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLS
Sbjct: 61 FVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLS 120
Query: 121 PPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL 180
PPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL
Sbjct: 121 PPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDIL 180
Query: 181 GGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGF 240
GGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGF
Sbjct: 181 GGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGF 240
Query: 241 FQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHM 300
FQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHM
Sbjct: 241 FQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHM 300
Query: 301 PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE 360
PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE
Sbjct: 301 PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE 360
Query: 361 QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG 420
QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG
Sbjct: 361 QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG 420
Query: 421 SYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNR 480
SYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNR
Sbjct: 421 SYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNR 480
Query: 481 PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC 540
PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC
Sbjct: 481 PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC 540
Query: 541 YLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
YLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV
Sbjct: 541 YLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDV 600
Query: 601 GEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW 648
GEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQA W
Sbjct: 601 GEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAKTLW 648
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 479 bits (1234), Expect = e-135
Identities = 269/660 (40%), Positives = 405/660 (61%), Gaps = 31/660 (4%)
Query: 69 LCLATPLTVSLRALVAGASRAPPARVASAPWSWLL-----VGYGAAGLSWSLWAVLSP-- 121
+CL + ++ L+ R P PW W L + GA+ L W L + + P
Sbjct: 89 VCLFVGIYAMVKLLLFSEVRRP----IRDPWFWALFVWTYISLGASFLLWWLLSTVRPGT 144
Query: 122 --------------PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGET 167
PG+ +Q + L +LL ++PD+ LVAA FFL++A LGET
Sbjct: 145 QALEPGAATEAEGFPGSGRPPPEQASGATLQ-KLLSYTKPDVAFLVAASFFLIVAALGET 203
Query: 168 LIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIRE 227
+P+Y+GR ID + F++A+ +CL + GSS +AG RGG FT +R+N+R+R
Sbjct: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
Query: 228 QLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLS 287
LF SL+ Q+ FF E +TG+L SRL+SDTT++S+ + N NV LR+ VKV G+ FM S
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
Query: 288 ISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGA 347
+S +L+L++ + P + +Y ++ + +E+Q+A+ARA E + ++TVRSF
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 348 EEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407
EE E Y L+Q +L + Y+ + L VQ+ +L G + G++T G
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443
Query: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGV 467
+L++F+IY+ +G ++++ +Y ++ VGAAEKVF ++DRQP + G+LAP L+G
Sbjct: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGR 503
Query: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
V F++V+F Y RP VL+ ++F+L PG+VTALVGP+GSGKS+ +L+N Y GG+V
Sbjct: 504 VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRV 563
Query: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
LLD KPIS Y+H YLH + V QEPVLF+ S+ +NI+YGL + + V+ AAQ A+A
Sbjct: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
Query: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQD 647
FI E++ G T+ GEKG+QL+ GQKQR+A+ARALVR+P VLILDEATSALD + E +Q
Sbjct: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 683
Query: 648 --WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRLM 702
+ TVL+IAHRL V+ AH I+VL +G++ + QL LY++LVQ++++
Sbjct: 684 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 479 bits (1234), Expect = e-135
Identities = 269/660 (40%), Positives = 405/660 (61%), Gaps = 31/660 (4%)
Query: 69 LCLATPLTVSLRALVAGASRAPPARVASAPWSWLL-----VGYGAAGLSWSLWAVLSP-- 121
+CL + ++ L+ R P PW W L + GA+ L W L + + P
Sbjct: 89 VCLFVGIYAMVKLLLFSEVRRP----IRDPWFWALFVWTYISLGASFLLWWLLSTVRPGT 144
Query: 122 --------------PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGET 167
PG+ +Q + L +LL ++PD+ LVAA FFL++A LGET
Sbjct: 145 QALEPGAATEAEGFPGSGRPPPEQASGATLQ-KLLSYTKPDVAFLVAASFFLIVAALGET 203
Query: 168 LIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIRE 227
+P+Y+GR ID + F++A+ +CL + GSS +AG RGG FT +R+N+R+R
Sbjct: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
Query: 228 QLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLS 287
LF SL+ Q+ FF E +TG+L SRL+SDTT++S+ + N NV LR+ VKV G+ FM S
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
Query: 288 ISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGA 347
+S +L+L++ + P + +Y ++ + +E+Q+A+ARA E + ++TVRSF
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 348 EEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407
EE E Y L+Q +L + Y+ + L VQ+ +L G + G++T G
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443
Query: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGV 467
+L++F+IY+ +G ++++ +Y ++ VGAAEKVF ++DRQP + G+LAP L+G
Sbjct: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGR 503
Query: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
V F++V+F Y RP VL+ ++F+L PG+VTALVGP+GSGKS+ +L+N Y GG+V
Sbjct: 504 VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRV 563
Query: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
LLD KPIS Y+H YLH + V QEPVLF+ S+ +NI+YGL + + V+ AAQ A+A
Sbjct: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
Query: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQD 647
FI E++ G T+ GEKG+QL+ GQKQR+A+ARALVR+P VLILDEATSALD + E +Q
Sbjct: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 683
Query: 648 --WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRLM 702
+ TVL+IAHRL V+ AH I+VL +G++ + QL LY++LVQ++++
Sbjct: 684 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 444 bits (1143), Expect = e-124
Identities = 262/660 (39%), Positives = 384/660 (58%), Gaps = 74/660 (11%)
Query: 69 LCLATPLTVSLRALVAGASRAPPARVASAPWSWLL-----VGYGAAGLSWSLWAVLSP-- 121
+CL + ++ L+ R P PW W L + GA+ L W L + + P
Sbjct: 89 VCLFVGIYAMVKLLLFSEVRRP----IRDPWFWALFVWTYISLGASFLLWWLLSTVRPGT 144
Query: 122 --------------PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGET 167
PG+ +Q + L +LL ++PD+ LVAA FFL++A LGET
Sbjct: 145 QALEPGAATEAEGFPGSGRPPPEQASGATLQ-KLLSYTKPDVAFLVAASFFLIVAALGET 203
Query: 168 LIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIRE 227
+P+Y+GR ID + F++A+ +CL + GSS +AG RGG FT +R+N+R+R
Sbjct: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
Query: 228 QLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLS 287
LF SL+ Q+ FF E +TG+L SRL+SDTT++S+ + N NV LR+ VKV G+ FM S
Sbjct: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
Query: 288 ISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGA 347
+S +L+L++ + P + +Y ++ + +E+Q+A+ARA E + ++TVRSF
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 348 EEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407
EE E Y L + +Q+Y E A Y+
Sbjct: 384 EEEEAEVY---LRKLQQVYKLNRKEAAAYMY----------------------------- 411
Query: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGV 467
++ SVGS +Y ++ VGAAEKVF ++DRQP + G+LAP L+G
Sbjct: 412 ----YVWGSGSVGS-------VYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGR 460
Query: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
V F++V+F Y RP VL+ ++F+L PG+VTALVGP+GSGKS+ +L+N Y GG+V
Sbjct: 461 VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRV 520
Query: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
LLD KPIS Y+H YLH + V QEPVLF+ S+ +NI+YGL + + V+ AAQ A+A
Sbjct: 521 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 580
Query: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQD 647
FI E++ G T+ GEKG+QL+ GQKQR+A+ARALVR+P VLILDEATSALD + E +Q
Sbjct: 581 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 640
Query: 648 --WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRLM 702
+ TVL+IAHRL V+ AH I+VL +G++ + QL LY++LVQ++++
Sbjct: 641 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 700
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 419 bits (1076), Expect = e-117
Identities = 276/720 (38%), Positives = 404/720 (56%), Gaps = 39/720 (5%)
Query: 12 LLLVDAALL-WLLQGPLGTLLPQGLPGL--WLEGTLRLGGLW----GLLKL--------- 55
LLL D LL L L+P LP L W G R LW G+L+
Sbjct: 88 LLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENA 147
Query: 56 --RGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPW----SWLLVGYGAA 109
+G L + L L LA P R L++ + W + +V Y AA
Sbjct: 148 GAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAA 207
Query: 110 GLSWSLWAVLSP---PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGE 166
+ +LW L PG Q + V RLL + L +VL+ LGE
Sbjct: 208 LPAAALWHKLGSLWVPGGQGGSGNPVR------RLLGCLGSETRRLSLFLVLVVLSSLGE 261
Query: 167 TLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIR 226
IP ++GR+ D + D F + M + + S++ G + TM ++ ++
Sbjct: 262 MAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQ 321
Query: 227 EQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFML 286
++F ++LRQ+ FFQ+ +TG + SR++ DT+ +S+ L N ++ L LV+ + L G ML
Sbjct: 322 GEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIML 381
Query: 287 SISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFG 346
S LT+++L+ +P K +Q + ++++++A++ QV EA+ + TVRSF
Sbjct: 382 WGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFA 441
Query: 347 AEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQ 406
EE E +++E L++ + L + + A+ + + +++ +L G Q + G ++
Sbjct: 442 NEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSS 501
Query: 407 GSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQG 466
G+L++F++YQ V+ L+ IY + VG++EK+F Y+DR P P G L P L+G
Sbjct: 502 GNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEG 561
Query: 467 VVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 526
+V+FQDVSFAYPNRPD VL+GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ
Sbjct: 562 LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 621
Query: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL-QSCEDDKVMAAAQAAHA 585
+LLD KP+ QYEH YLH QV +VGQEP +F S++ NIAYGL Q +++ AAA + A
Sbjct: 622 LLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGA 681
Query: 586 DDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD----VQC 641
FI + G T+V E GSQL+ GQ+Q +A+ARAL+R P VLILD+ATSALD +Q
Sbjct: 682 HSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQV 741
Query: 642 EQALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK---LAQLQEGQDLYSRLVQ 698
EQ L + R R+VL+I L V++A IL L+ G +++ QL E + Y +VQ
Sbjct: 742 EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 322 bits (825), Expect = 7e-88
Identities = 221/645 (34%), Positives = 345/645 (53%), Gaps = 20/645 (3%)
Query: 56 RGLLGFVGTLLLPLCLATPLTVSLRALVA-GASRAPPARVASAPWSWLLVGYGAAGLSWS 114
RG+LG LL L P + A GA R P AR P + G A W
Sbjct: 81 RGVLGLAR--LLGLWARGPGSCRCGAFAGPGAPRLPRARFPGGPAAAAWAGDEA----WR 134
Query: 115 LWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSG 174
+PPG + + + +LL L+ P+ L AA FL ++ + P + G
Sbjct: 135 RGPA-APPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLG 193
Query: 175 RVIDILGG----DFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLF 230
++ID++ D+ + + +F G++ +A R + RI R+R LF
Sbjct: 194 KIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANA-IRVYLMQTSGQRIVNRLRTSLF 252
Query: 231 SSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISP 290
SS+LRQ++ FF +T+TGEL +RLSSDT L+ + N + LR+ + M +SP
Sbjct: 253 SSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSP 312
Query: 291 RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEH 350
L L +P +Y +++ + QD++A+A Q+ E +G ++TVR+FG E
Sbjct: 313 NLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMT 372
Query: 351 EVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLL 410
E+ +Y ++ QL + RA + + + + +L G M +T G L
Sbjct: 373 EIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELS 432
Query: 411 SFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP-SPGT-LAPTTLQGVV 468
SF++Y VG + L Y +++ +GA +++ ++R+P LP + G L + QG +
Sbjct: 433 SFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGAL 492
Query: 469 KFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVL 528
+F++V FAYP RP+ P+ + + ++ G VTALVGP+GSGKSTV +LL LY P G +
Sbjct: 493 EFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTIS 552
Query: 529 LDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL---QSCEDDKVMAAAQAAHA 585
LD I Q +L S++ +V QEP+LFS S+ NIAYG S +++ A+ A+A
Sbjct: 553 LDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANA 612
Query: 586 DDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQAL 645
FI+ G T VGEKG L+ GQKQR+AIARAL+++P++L+LDEATSALD + E +
Sbjct: 613 VAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLV 672
Query: 646 QDWNSR--GDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
Q+ R RTVLVIAHRL ++ A+ + VL +GK+ + + +E
Sbjct: 673 QEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEE 717
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 319 bits (818), Expect = 5e-87
Identities = 211/585 (36%), Positives = 322/585 (55%), Gaps = 19/585 (3%)
Query: 134 NKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILG-------GDFDP 186
N L W+ L P L +L A + A L IP G++++++ G F
Sbjct: 116 NWKLFWQFL---HPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMT 172
Query: 187 HAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKT 246
+ + + L+ L+ G ++ R+ + +R LFSSLLRQD+ FF KT
Sbjct: 173 ESQNLSTHLLILYGVQGLLTFGYLV-LLSHVGERMAVDMRRALFSSLLRQDITFFDANKT 231
Query: 247 GELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAA 306
G+L SRL++D + L + LRS +V G + +S RLTLL ++ P +
Sbjct: 232 GQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGV 291
Query: 307 EKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLY 366
+ + +++ R+ Q+ +ARA V EA+G ++TVR+F E+ E RY LE CR
Sbjct: 292 GTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRA 351
Query: 367 WRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTL 426
AL+ + + + + L G + +LT G L+SF++ ++V + L
Sbjct: 352 EELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANL 411
Query: 427 VYIYGDMLSNVGAAEKVFSYMDRQPNLP-SPGTLAPTT-LQGVVKFQDVSFAYPNRPDRP 484
++G ++ + A +VF YM P +P S G P L+G V FQ+V F+YP RP
Sbjct: 412 SVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFE 471
Query: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544
VLK T TL PG++ ALVG +G GK+TVA+LL+ Y PT G V+LD + + + +L
Sbjct: 472 VLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRG 531
Query: 545 QVVS-VGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEK 603
QVV + QEPVLF ++ NI +G D++V AA+ A+A +FI G T VGE+
Sbjct: 532 QVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGER 591
Query: 604 GSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGD--RTVLVIAH 661
G+ L+ GQKQRLAIARAL++ P VLILDEATSALD + E+ +Q+ R RTVLVIAH
Sbjct: 592 GTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAH 651
Query: 662 RLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRLMD 703
RL V+ AH I+V+ +G++ + +L + LY+ L++++ +D
Sbjct: 652 RLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQALD 696
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 245 bits (625), Expect = 1e-64
Identities = 159/488 (32%), Positives = 272/488 (55%), Gaps = 21/488 (4%)
Query: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
+IR+Q F +++RQ++G+F GELN+RL+ D + ++ + + +S+ G
Sbjct: 146 KIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATF--FTG 203
Query: 284 FMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVARAGQVVREAVG 337
F++ + +LTL+ L P + V+ ++L D A A+AG V E +
Sbjct: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVW----AKILSSFTDKELLAYAKAGAVAEEVLA 259
Query: 338 GLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ 397
++TV +FG ++ E+ RY + LE+ +++ ++ + + + +L L G
Sbjct: 260 AIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTT 319
Query: 398 QMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLPSP 456
+ GE + G +L+ + + +G++ + +N GAA ++F +D +P++ S
Sbjct: 320 LVLSGEYSIGQVLT-VFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSY 378
Query: 457 GTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAA 514
P ++G ++F++V F+YP+R + +LKGL ++ G+ ALVG +G GKST
Sbjct: 379 SKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQ 438
Query: 515 LLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDD 574
L+Q LY PT G V +D + I +L + V QEPVLF+ ++ NI YG ++ D
Sbjct: 439 LMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMD 498
Query: 575 KVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEAT 634
++ A + A+A DFI ++ H T VGE+G+QL+ GQKQR+AIARALVR+P++L+LDEAT
Sbjct: 499 EIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 558
Query: 635 SALDVQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEG 689
SALD + E +Q +R RT +VIAHRL V+ A I +G + + +L +
Sbjct: 559 SALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKE 618
Query: 690 QDLYSRLV 697
+ +Y +LV
Sbjct: 619 KGIYFKLV 626
Score = 236 bits (602), Expect = 5e-62
Identities = 179/581 (30%), Positives = 290/581 (49%), Gaps = 56/581 (9%)
Query: 136 VLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDPHAFA-- 190
V WR++KL+ + P V F A++ L P ++ ++I + DP
Sbjct: 695 VSFWRIMKLNLTEWPYFVVGVF---CAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQN 751
Query: 191 SAIFFMCLFSFG--SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--T 246
S +F + + G S ++ +G F + R+R +F S+LRQD+ +F + K T
Sbjct: 752 SNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTT 811
Query: 247 GELNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHM 300
G L +RL++D + + V+ +++ + +YG+ +LTLL L +
Sbjct: 812 GALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW------QLTLLLLAIV 865
Query: 301 PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE 360
P A V + + + +G++ EA+ +TV S E+ +++
Sbjct: 866 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQ----KFEHMYA 921
Query: 361 QCRQLYWRRDLERA-------------LYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407
Q Q+ +R L +A +Y G ++ L +D L
Sbjct: 922 QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLVFS 979
Query: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQ 465
+++ + V S+ D +A + +++ P + S T L P TL+
Sbjct: 980 AVVFGAMAVGQVSSFAP-------DYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLE 1032
Query: 466 GVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGG 525
G V F +V F YP RPD PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G
Sbjct: 1033 GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1092
Query: 526 QVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAA 583
+VLLD K I + +L + + V QEP+LF S+ NIAYG S ++++ AA+ A
Sbjct: 1093 KVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1152
Query: 584 HADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643
+ FI+ + + T VG+KG+QL+ GQKQR+AIARALVR P +L+LDEATSALD + E+
Sbjct: 1153 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1212
Query: 644 ALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
+Q+ +R RT +VIAHRL +Q A I+V Q G++++
Sbjct: 1213 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE 1253
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 243 bits (621), Expect = 3e-64
Identities = 167/506 (33%), Positives = 274/506 (54%), Gaps = 31/506 (6%)
Query: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273
+T R +IR++ F ++LRQ++G+F T ELN+RL+ D + +S + + +
Sbjct: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
Query: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327
++ GF++ +LTL+ + P + V+ ++L D A A+
Sbjct: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
Query: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387
AG V EA+G ++TV +FG + E+ RY++ LE +++ ++ + + + + +L
Sbjct: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
Query: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442
L G + E T G+ + S +I SVG + D +N GAA
Sbjct: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
Query: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
+F +D P + S P +++G ++F DV F+YP+R + +LKGL ++ G+ A
Sbjct: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
Query: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
LVG +G GKST L+Q LY P G + +D + I + YL + V QEPVLFS ++
Sbjct: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
Query: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
NI YG + D++ A + A+A +FI ++ T VGE+G+QL+ GQKQR+AIARA
Sbjct: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
Query: 621 LVRDPRVLILDEATSALDVQCE---QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQE 677
LVR+P++L+LDEATSALD + E QA D +R RT +VIAHRL V+ A I ++
Sbjct: 547 LVRNPKILLLDEATSALDTESEAEVQAALD-KAREGRTTIVIAHRLSTVRNADVIAGFED 605
Query: 678 GKLQKL---AQLQEGQDLYSRLVQQR 700
G + + ++L + + +Y +LV +
Sbjct: 606 GVIVEQGSHSELMKKEGVYFKLVNMQ 631
Score = 218 bits (554), Expect = 2e-56
Identities = 176/582 (30%), Positives = 291/582 (50%), Gaps = 60/582 (10%)
Query: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190
++LKL++ + P V V A+ L P +S +I I G D + F+
Sbjct: 699 KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
Query: 191 SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248
F+ + SF + G G ++R R+R F ++LRQD+ +F + K TG
Sbjct: 756 LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
Query: 249 LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302
L++RL++D + ++ +++ + +YG+ +LTLL L +P
Sbjct: 813 LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
Query: 303 TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362
+ V + + + AG++ EA+ ++TV S E Y E
Sbjct: 867 IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
Query: 363 RQLY--WRRDLERA-LYLLVRRVLHLGVQMLMLSC---GLQQMQDGELTQGSLL---SFM 413
+LY +R +++A +Y + + + C G + +G + ++ S +
Sbjct: 922 -KLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI 980
Query: 414 IYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQ 471
++ + + Y + + AA +F +RQP + S L P +G + F
Sbjct: 981 VFGAVALGHASSFAPDYAK--AKLSAAH-LFMLFERQPLIDSYSEEGLKPDKFEGNITFN 1037
Query: 472 DVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV---- 527
+V F YP R + PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G V
Sbjct: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDF 1097
Query: 528 ---LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQA 582
LLD + + +L +Q+ V QEP+LF S+ NIAYG S D++++AA+A
Sbjct: 1098 GFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKA 1157
Query: 583 AHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
A+ FI+ + H T VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E
Sbjct: 1158 ANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE 1217
Query: 643 QALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
+ +Q+ +R RT +VIAHRL +Q A I+V Q G++++
Sbjct: 1218 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE 1259
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 243 bits (621), Expect = 3e-64
Identities = 167/506 (33%), Positives = 274/506 (54%), Gaps = 31/506 (6%)
Query: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273
+T R +IR++ F ++LRQ++G+F T ELN+RL+ D + +S + + +
Sbjct: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
Query: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327
++ GF++ +LTL+ + P + V+ ++L D A A+
Sbjct: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
Query: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387
AG V EA+G ++TV +FG + E+ RY++ LE +++ ++ + + + + +L
Sbjct: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
Query: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442
L G + E T G+ + S +I SVG + D +N GAA
Sbjct: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
Query: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
+F +D P + S P +++G ++F DV F+YP+R + +LKGL ++ G+ A
Sbjct: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
Query: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
LVG +G GKST L+Q LY P G + +D + I + YL + V QEPVLFS ++
Sbjct: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
Query: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
NI YG + D++ A + A+A +FI ++ T VGE+G+QL+ GQKQR+AIARA
Sbjct: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
Query: 621 LVRDPRVLILDEATSALDVQCE---QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQE 677
LVR+P++L+LDEATSALD + E QA D +R RT +VIAHRL V+ A I ++
Sbjct: 547 LVRNPKILLLDEATSALDTESEAEVQAALD-KAREGRTTIVIAHRLSTVRNADVIAGFED 605
Query: 678 GKLQKL---AQLQEGQDLYSRLVQQR 700
G + + ++L + + +Y +LV +
Sbjct: 606 GVIVEQGSHSELMKKEGVYFKLVNMQ 631
Score = 217 bits (553), Expect = 3e-56
Identities = 173/566 (30%), Positives = 274/566 (48%), Gaps = 82/566 (14%)
Query: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190
++LKL++ + P V V A+ L P +S +I I G D + F+
Sbjct: 699 KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
Query: 191 SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248
F+ + SF + G G ++R R+R F ++LRQD+ +F + K TG
Sbjct: 756 LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
Query: 249 LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302
L++RL++D + ++ +++ + +YG+ +LTLL L +P
Sbjct: 813 LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
Query: 303 TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362
+ V + + + AG++ EA+ ++TV S E Y E
Sbjct: 867 IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
Query: 363 RQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSY 422
+LY + A+ G + G SF Y
Sbjct: 922 -KLYGPYRVFSAIVF------------------------GAVALGHASSF------APDY 950
Query: 423 VQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQDVSFAYPNR 480
+ + +A +F +RQP + S L P +G + F +V F YP R
Sbjct: 951 AKAKL-----------SAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTR 999
Query: 481 PDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHC 540
+ PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G VLLD + +
Sbjct: 1000 ANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQ 1059
Query: 541 YLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHADDFIQEMEHGIYT 598
+L +Q+ V QEP+LF S+ NIAYG S D++++AA+AA+ FI+ + H T
Sbjct: 1060 WLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYET 1119
Query: 599 DVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW--NSRGDRTV 656
VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E+ +Q+ +R RT
Sbjct: 1120 RVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTC 1179
Query: 657 LVIAHRLQAVQRAHQILVLQEGKLQK 682
+VIAHRL +Q A I+V Q G++++
Sbjct: 1180 IVIAHRLSTIQNADLIVVFQNGRVKE 1205
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 243 bits (621), Expect = 3e-64
Identities = 167/506 (33%), Positives = 274/506 (54%), Gaps = 31/506 (6%)
Query: 214 FTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLR 273
+T R +IR++ F ++LRQ++G+F T ELN+RL+ D + +S + + +
Sbjct: 138 WTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQ 197
Query: 274 SLVKVVGLYGFMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVAR 327
++ GF++ +LTL+ + P + V+ ++L D A A+
Sbjct: 198 AVATFFA--GFIVGFIRGWKLTLVIMAISPILGLSAAVW----AKILSAFSDKELAAYAK 251
Query: 328 AGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGV 387
AG V EA+G ++TV +FG + E+ RY++ LE +++ ++ + + + + +L
Sbjct: 252 AGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYAS 311
Query: 388 QMLMLSCGLQQMQDGELTQGSLL----SFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEK 442
L G + E T G+ + S +I SVG + D +N GAA
Sbjct: 312 YALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCI-----DAFANARGAAYV 366
Query: 443 VFSYMDRQPNLPSPGTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
+F +D P + S P +++G ++F DV F+YP+R + +LKGL ++ G+ A
Sbjct: 367 IFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVA 426
Query: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
LVG +G GKST L+Q LY P G + +D + I + YL + V QEPVLFS ++
Sbjct: 427 LVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTI 486
Query: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
NI YG + D++ A + A+A +FI ++ T VGE+G+QL+ GQKQR+AIARA
Sbjct: 487 AENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARA 546
Query: 621 LVRDPRVLILDEATSALDVQCE---QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQE 677
LVR+P++L+LDEATSALD + E QA D +R RT +VIAHRL V+ A I ++
Sbjct: 547 LVRNPKILLLDEATSALDTESEAEVQAALD-KAREGRTTIVIAHRLSTVRNADVIAGFED 605
Query: 678 GKLQKL---AQLQEGQDLYSRLVQQR 700
G + + ++L + + +Y +LV +
Sbjct: 606 GVIVEQGSHSELMKKEGVYFKLVNMQ 631
Score = 224 bits (572), Expect = 2e-58
Identities = 176/575 (30%), Positives = 291/575 (50%), Gaps = 53/575 (9%)
Query: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDP------HAFA 190
++LKL++ + P V V A+ L P +S +I I G D + F+
Sbjct: 699 KVLKLNKTEWPYFVVG---TVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 755
Query: 191 SAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--TGE 248
F+ + SF + G G ++R R+R F ++LRQD+ +F + K TG
Sbjct: 756 LIFLFLGIISFFTFFLQGFTFGKAGEILTR---RLRSMAFKAMLRQDMSWFDDHKNSTGA 812
Query: 249 LNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHMPF 302
L++RL++D + ++ +++ + +YG+ +LTLL L +P
Sbjct: 813 LSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGW------QLTLLLLAVVPI 866
Query: 303 TIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQC 362
+ V + + + AG++ EA+ ++TV S E Y E
Sbjct: 867 IAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVE----- 921
Query: 363 RQLY--WRRDLERA-LYLLVRRVLHLGVQMLMLSC---GLQQMQDGELTQGSLL---SFM 413
+LY +R +++A +Y + + + C G + +G + ++ S +
Sbjct: 922 -KLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAI 980
Query: 414 IYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQGVVKFQ 471
++ + + Y + + AA +F +RQP + S L P +G + F
Sbjct: 981 VFGAVALGHASSFAPDYAK--AKLSAAH-LFMLFERQPLIDSYSEEGLKPDKFEGNITFN 1037
Query: 472 DVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDE 531
+V F YP R + PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G VLLD
Sbjct: 1038 EVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDG 1097
Query: 532 KPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHADDFI 589
+ + +L +Q+ V QEP+LF S+ NIAYG S D++++AA+AA+ FI
Sbjct: 1098 QEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFI 1157
Query: 590 QEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW- 648
+ + H T VG+KG+QL+ GQKQR+AIARAL+R P++L+LDEATSALD + E+ +Q+
Sbjct: 1158 ETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1217
Query: 649 -NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
+R RT +VIAHRL +Q A I+V Q G++++
Sbjct: 1218 DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE 1252
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 233 bits (595), Expect = 3e-61
Identities = 189/596 (31%), Positives = 300/596 (50%), Gaps = 52/596 (8%)
Query: 135 KVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGD------FD 185
+V + ++LKL++P+ P +V + +VL T+ P +S ++I + G + D
Sbjct: 230 EVSLLKILKLNKPEWPFVVLG---TLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHD 286
Query: 186 PHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFF--QE 243
++ + + F S G G + +R+R F ++L QD+ +F +E
Sbjct: 287 AEIYSMIFVILGVICFVSYFMQGLFYG---RAGEILTMRLRHLAFKAMLYQDIAWFDEKE 343
Query: 244 TKTGELNSRLSSDTTLMSNWLPLNANVLLRSL------VKVVGLYGF-----MLSISPRL 292
TG L + L+ D + VL ++ V + +YG+ +LSI+P L
Sbjct: 344 NSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVL 403
Query: 293 TLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEV 352
+ ++ T A N QE+ AG++ EA+ ++T+ S E+
Sbjct: 404 AVTGMIE---TAAMTGFANKDKQEL--------KHAGKIATEALENIRTIVSLTREKAFE 452
Query: 353 CRYKEALE-QCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELT-QGSLL 410
Y+E L+ Q R + + + Y ++ G +Q G +T +G +
Sbjct: 453 QMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAA-GFRFGAYLIQAGRMTPEGMFI 511
Query: 411 SFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLA--PTTLQGVV 468
F + +TLV + GAA +F+ ++++PN+ S P T +G +
Sbjct: 512 VFTAIAYGAMAIGETLVLAPEYSKAKSGAAH-LFALLEKKPNIDSRSQEGKKPDTCEGNL 570
Query: 469 KFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVL 528
+F++VSF YP RPD +L+GL+ ++ G+ A VG +G GKST LLQ LY P GQVL
Sbjct: 571 EFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVL 630
Query: 529 LDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAAHAD 586
D + +L SQ+ V QEPVLF+ S+ NIAYG S D++ AA AA+
Sbjct: 631 FDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIH 690
Query: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ 646
FI+ + T VG KG+QL+ GQKQRLAIARAL++ P++L+LDEATSALD E+ +Q
Sbjct: 691 SFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQ 750
Query: 647 DW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE---GQDLYSRLV 697
+R RT LV+ HRL A+Q A I+VL GK+++ QE +D+Y +LV
Sbjct: 751 HALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLV 806
Score = 132 bits (332), Expect = 1e-30
Identities = 78/179 (43%), Positives = 113/179 (63%), Gaps = 7/179 (3%)
Query: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
++DE I + + V QEPVLF ++ NNI YG D+++ AA+ A+A D
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQ- 646
FI E + T VGEKG+Q++ GQKQR+AIARALVR+P++LILDEATSALD + + A+Q
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 647 --DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQEGQDLYSRLVQQR 700
+ S+G RT +V+AHRL ++ A I+ L++G L + A+L + LY LV +
Sbjct: 121 ALEKASKG-RTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 226 bits (577), Expect = 4e-59
Identities = 174/566 (30%), Positives = 267/566 (47%), Gaps = 43/566 (7%)
Query: 140 RLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDF--DPHAFASAIFFMC 197
R+LK S P+ P ++ V A + T+ P Y+ ILG D S I +C
Sbjct: 743 RILKFSAPEWPYMLVGS---VGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVC 799
Query: 198 LFSFG----SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKT--GELNS 251
L S + +G F + + R+R+ F ++L QD+ +F + + G L +
Sbjct: 800 LLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTT 859
Query: 252 RLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYN 311
RL++D + + +++ S V S S +L+L+ L PF +
Sbjct: 860 RLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQT 919
Query: 312 TRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDL 371
+ A+ GQ+ EA+ ++TV G E R+ EALE +L
Sbjct: 920 RMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKER----RFIEALE--------TEL 967
Query: 372 ERALYLLVRRVLHLGVQMLMLSC------GLQQMQDGELTQGSLLSFMIYQESVGSYV-- 423
E+ +++ G C G L L F + + V
Sbjct: 968 EKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLS 1027
Query: 424 -----QTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAP--TTLQGVVKFQDVSFA 476
+ Y + + AA + F +DRQP + T QG + F D F
Sbjct: 1028 ATALGRAFSYTPSYAKAKISAA-RFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFT 1086
Query: 477 YPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQ 536
YP+RPD VL GL+ ++ PG+ A VG +G GKST LL+ Y P G+V++D +
Sbjct: 1087 YPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK 1146
Query: 537 YEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCE--DDKVMAAAQAAHADDFIQEMEH 594
+L S + V QEPVLF+ S+ +NI YG + E ++V+AAA+ A DF+ +
Sbjct: 1147 VNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPE 1206
Query: 595 GIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW--NSRG 652
T+VG +GSQL+ G+KQR+AIARA+VRDP++L+LDEATSALD + E+ +Q +R
Sbjct: 1207 KYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKARE 1266
Query: 653 DRTVLVIAHRLQAVQRAHQILVLQEG 678
RT +VIAHRL +Q A I V+ +G
Sbjct: 1267 GRTCIVIAHRLSTIQNADIIAVMAQG 1292
Score = 219 bits (558), Expect = 7e-57
Identities = 151/488 (30%), Positives = 254/488 (52%), Gaps = 20/488 (4%)
Query: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
++R+ F ++R ++G+F GELN+R S D +++ + + ++ + + G
Sbjct: 173 KMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTI--CG 230
Query: 284 FMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQT 341
F+L +LTL+ + P + A A+AG V E + ++T
Sbjct: 231 FLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRT 290
Query: 342 VRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL-LVRRVLHLGVQMLMLSCGLQQMQ 400
V +FG E+ EV RY++ L ++ R+ + + V ++ L + +
Sbjct: 291 VAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLD 350
Query: 401 DGELTQGSL----LSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP-- 454
+GE T G+L LS ++ ++G+ L + AA +F +DR+P +
Sbjct: 351 EGEYTPGTLVQIFLSVIVGALNLGNASPCLEAF----ATGRAAATSIFETIDRKPIIDCM 406
Query: 455 SPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAA 514
S ++G ++F +V+F YP+RP+ +L L ++PGE+TALVGP+G+GKST
Sbjct: 407 SEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQ 466
Query: 515 LLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDD 574
L+Q Y P G V +D I +L Q+ V QEPVLFS ++ NI YG + +
Sbjct: 467 LIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATME 526
Query: 575 KVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEAT 634
++ AA+ A+A +FI ++ T VGE G Q++ GQKQR+AIARAL+R+P++L+LD AT
Sbjct: 527 DIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMAT 586
Query: 635 SALDVQCEQALQDWNSR--GDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEG 689
SALD + E +Q+ S+ T++ +AHRL V+ A I+ + G + +L E
Sbjct: 587 SALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLER 646
Query: 690 QDLYSRLV 697
+ +Y LV
Sbjct: 647 KGVYFTLV 654
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 200 bits (509), Expect = 3e-51
Identities = 183/654 (27%), Positives = 309/654 (47%), Gaps = 66/654 (10%)
Query: 103 LVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLM--WR-----LLKLSRPDLPLLVAA 155
++G A GL + + Q+ E+ QV + WR L LS P A
Sbjct: 201 VLGLWAPGLRPQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPA 260
Query: 156 FFFLVLAVLG--------ETLIPHYSGRVIDILGGDFDPHAFA---SAIFFMCLFSFGSS 204
+VL LG L+P + ++++L ++ A ++ F+ G +
Sbjct: 261 LQLVVLICLGLMGLERALNVLVPIFYRNIVNLLTEKAPWNSLAWTVTSYVFLKFLQGGGT 320
Query: 205 LSAGCRGGCFTYTMSRI----NLRIREQLFSSLLRQDLGFFQETKTGE---LNSRLSSDT 257
S G T+ R+ + R+ +FS L L + +TGE + R +S
Sbjct: 321 GSTGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSV 380
Query: 258 TLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEV 317
T + ++L N L ++ +G+ F + + L+ L M + V +
Sbjct: 381 TGLLSYLVFNVIPTLADII--IGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKF 438
Query: 318 LREI--QDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERAL 375
R + Q+ RA V +++ +TV+ + AE +EV RY+EA+ + + L W+ L
Sbjct: 439 RRAMNTQENATRARAV--DSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVL 496
Query: 376 YLLVRR-VLHLGVQMLMLSCGL----QQMQDGELTQGSLLSFMIYQES--VGSYVQTLVY 428
+ V+ LG+ L C Q++Q G+ +Y G+Y + +
Sbjct: 497 LNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQT 556
Query: 429 IYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQ-GVVKFQDVSFAYPNRPDRPVLK 487
+ DM E +F + + + P Q G ++F++V F+Y + R L+
Sbjct: 557 NFIDM-------ENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYAD--GRETLQ 607
Query: 488 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVV 547
++FT+ PG+ ALVGP+G+GKST+ LL Y + G + +D + ISQ L S +
Sbjct: 608 DVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIG 667
Query: 548 SVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQL 607
V Q+ VLF+ ++ +NI YG + +D+V AAAQAA D I G T VGE+G +L
Sbjct: 668 VVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKL 727
Query: 608 AAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSR--GDRTVLVIAHRLQA 665
+ G+KQR+AIAR +++ P +++LDEATSALD E+A+Q ++ +RT +V+AHRL
Sbjct: 728 SGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLST 787
Query: 666 VQRAHQILVLQEGKLQK----------------LAQLQEGQDLYSRLVQQRLMD 703
V A QILV+++G + + + QLQ+GQ+ S + + M+
Sbjct: 788 VVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSEDTKPQTME 841
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 187 bits (476), Expect = 2e-47
Identities = 156/516 (30%), Positives = 253/516 (49%), Gaps = 31/516 (6%)
Query: 186 PHAFASAIFFMCLFSFGSSLSAGC---RGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQ 242
P+ + F++ +++ + +++ C R F + + +L +L + FF
Sbjct: 930 PNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFN 989
Query: 243 ETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPF 302
T TG + +R SSD + LP N+LL + GL G + + L L LL P
Sbjct: 990 ATPTGRILNRFSSDVACADDSLPFILNILLAN---AAGLLGLLAVLGSGLPWLLLLLPPL 1046
Query: 303 TIA---AEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAE---EHEVCRYK 356
+I ++ Y +E+ R ++ + + + GL +R+ GA E E R
Sbjct: 1047 SIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLL 1106
Query: 357 EALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCG--LQQMQDGELTQGSLLSFMI 414
E ++C+ + L R+ +G ++ G L Q Q G G + +
Sbjct: 1107 ELNQRCQFA-----TSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLS 1161
Query: 415 YQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTT---LQGVVKFQ 471
Y S+ + LV + + + + E++ Y P P L T QG V+FQ
Sbjct: 1162 YALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQ 1221
Query: 472 DVSFAYPNRPDRP-VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLD 530
DV AY RP P L G+TF ++PGE +VG GSGKS++ +L L +P+ G+VLLD
Sbjct: 1222 DVVLAY--RPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLD 1279
Query: 531 EKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNI-AYGLQSCEDDKVMAAAQAAHADDFI 589
SQ E L SQ+ + QEP LFSG+VR N+ GL +D + A + H + I
Sbjct: 1280 GVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLH--KDRALWQALKQCHLSEVI 1337
Query: 590 QEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWN 649
M G+ ++GE G L+ GQ+Q L +ARAL+ D ++L +DEAT+++D + +Q LQ
Sbjct: 1338 TSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTI 1396
Query: 650 SR--GDRTVLVIAHRLQAVQRAHQILVLQEGKLQKL 683
+ ++TVL IAHRL + + ++LVLQ G++ +L
Sbjct: 1397 CKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVEL 1432
Score = 67.4 bits (163), Expect = 4e-11
Identities = 49/196 (25%), Positives = 95/196 (48%), Gaps = 24/196 (12%)
Query: 493 LRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQE 552
++ G + +VG G GKS++ A + G V + L QE
Sbjct: 595 VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQE 644
Query: 553 PVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQK 612
P + ++R+NI +G ++ + +A +D + + G T+VGEKG L+ GQ+
Sbjct: 645 PWIQFATIRDNILFG-KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQR 703
Query: 613 QRLAIARALVRDPRVLILDEATSALDV--------QCEQALQDWNSRGDRTVLVIAHRLQ 664
R+A+ARA+ ++ + +LD+ +A+D +C + + +R L+ HR +
Sbjct: 704 ARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTR-----LLCTHRTE 758
Query: 665 AVQRAHQILVLQEGKL 680
++RA +L+++ G+L
Sbjct: 759 YLERADAVLLMEAGRL 774
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 167 bits (423), Expect = 3e-41
Identities = 135/499 (27%), Positives = 250/499 (50%), Gaps = 53/499 (10%)
Query: 210 RGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNAN 269
RG F R + R+ ++LF +LR + FF T TG + +R S D + LP A
Sbjct: 932 RGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAE 991
Query: 270 VLLRSLVKVVGLYG--------FMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREI 321
+ +++++ V G F++++ P + L S+LH+ + ++RE+
Sbjct: 992 MFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRV------------LIREL 1039
Query: 322 Q--DAVARAGQV--VREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL 377
+ D + ++ + + ++ GL T+ ++ + + RY+E L+ D + +L
Sbjct: 1040 KRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLD---------DNQAPFFL 1090
Query: 378 LVRRVLHLGVQMLMLSCGLQQ-------MQDGELTQGSLLSFMIYQESVGSYVQTLVYIY 430
+ L V++ ++S L + G++ + Y + Q V +
Sbjct: 1091 FTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLA 1150
Query: 431 GDMLSNVGAAEKVFSYMDRQPNLPSPGTL---APTT---LQGVVKFQDVSFAYPNRPDRP 484
+ + + E++ Y+ + +L +P + AP+ +G V F++ Y R + P
Sbjct: 1151 SETEARFTSVERINHYI-KTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRY--RENLP 1207
Query: 485 -VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLH 543
VLK ++FT++P E +VG GSGKS++ L L + +GG + +D IS L
Sbjct: 1208 LVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLR 1267
Query: 544 SQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEK 603
S++ + QEPVLFSG+VR+N+ Q E D++ A + H + I ++ + ++V E
Sbjct: 1268 SKLSIIPQEPVLFSGTVRSNLDPFNQYTE-DQIWDALERTHMKECIAQLPLKLESEVMEN 1326
Query: 604 GSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDW--NSRGDRTVLVIAH 661
G + G++Q L IARAL+R ++LILDEAT+A+D + + +Q+ + D T+L IAH
Sbjct: 1327 GDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAH 1386
Query: 662 RLQAVQRAHQILVLQEGKL 680
RL V + +I+VL +G++
Sbjct: 1387 RLHTVLGSDRIMVLAQGQV 1405
Score = 72.4 bits (176), Expect = 1e-12
Identities = 53/211 (25%), Positives = 107/211 (50%), Gaps = 19/211 (9%)
Query: 486 LKGLTFTLRPGEVTALVGPNGSGK-STVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544
L + ++ G++ + G GSGK S ++A+L GQ+ L E I+ +
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAIL--------GQMTLLEGSIA------ISG 623
Query: 545 QVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKG 604
V Q+ + + ++R+NI +G + ++++ + + + + T++GE+G
Sbjct: 624 TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERG 682
Query: 605 SQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSR---GDRTVLVIAH 661
+ L+ GQ+QR+++ARAL D + ILD+ SALD + + R +TVL + H
Sbjct: 683 ANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTH 742
Query: 662 RLQAVQRAHQILVLQEGKLQKLAQLQEGQDL 692
+LQ + +++ ++EG + + +E +L
Sbjct: 743 QLQYLVDCDEVIFMKEGCITERGTHEELMNL 773
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 163 bits (413), Expect = 4e-40
Identities = 146/479 (30%), Positives = 231/479 (48%), Gaps = 40/479 (8%)
Query: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDT--------TLMSNWLPLNANVLLRSL 275
RI + +F L DLGF +TG L+ + T L+ N LP+ V+L
Sbjct: 225 RIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVML--- 281
Query: 276 VKVVGLYGFMLSISPRLTLLSLL--HMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVR 333
V G+ + L L L + FT+A + + TR + E+ A AG
Sbjct: 282 --VSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTR-WRTRFRI---EMNKADNDAGNAAI 335
Query: 334 EAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRR-VLHLGVQMLML 392
+++ +TV+ F E +E RY L+ + A+ + + +G+ +M+
Sbjct: 336 DSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMV 395
Query: 393 SCGLQQMQDGELTQGSLLSF--MIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMD-- 448
Q + G LT G L+ +++Q S+ + L +Y + + +F+ +
Sbjct: 396 LAS-QGIVAGTLTVGDLVMVNGLLFQLSLP--LNFLGTVYRETRQALIDMNTLFTLLKVD 452
Query: 449 ---RQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPN 505
+ + SP + P T V F +V F Y + VL G++F + G+ A+VG +
Sbjct: 453 TQIKDKVMASPLQITPQT--ATVAFDNVHFEYIE--GQKVLSGISFEVPAGKKVAIVGGS 508
Query: 506 GSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIA 565
GSGKST+ LL Y+P G + L + I L V V Q+ VLF ++ N+
Sbjct: 509 GSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLL 568
Query: 566 YGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDP 625
YG S ++V A A+ A D I M HG T VGE+G +L+ G+KQR+AIARA+++DP
Sbjct: 569 YGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDP 628
Query: 626 RVLILDEATSALDVQCEQ----ALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
V++ DEATS+LD E+ A++D RT + IAHRL V A +I+VL +GK+
Sbjct: 629 PVILYDEATSSLDSITEETILGAMKDVVKH--RTSIFIAHRLSTVVDADEIIVLDQGKV 685
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 161 bits (407), Expect = 2e-39
Identities = 147/580 (25%), Positives = 267/580 (46%), Gaps = 36/580 (6%)
Query: 125 QEKEQDQVNNKVLMWRLLKLSRPDLP------LLVAAFFFLVLAVLGETLIPHYSGRVID 178
+E+E+D+ +N + RL R +P L + FFL++ ++ L+ H ID
Sbjct: 921 EEEEEDEDDNMSTVMRL----RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAID 976
Query: 179 ILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLR---------IREQL 229
+ + + + S C G F ++ + + + L
Sbjct: 977 YWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNL 1036
Query: 230 FSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSIS 289
+ ++ + FF T G + +R S+DT ++ +P L RS + + G M+S +
Sbjct: 1037 LNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG-MISYA 1095
Query: 290 PRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQV-VREAVGGLQTVRSFGAE 348
+ L++LL + + Y + L+E+ D+ E GL T+R+F E
Sbjct: 1096 TPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHE 1155
Query: 349 EHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGS 408
R E + Y L A L R +LG ++L+ + + G G
Sbjct: 1156 TRFKQRMLELTDTNNIAYLF--LSAANRWLEVRTDYLGA-CIVLTASIASIS-GSSNSGL 1211
Query: 409 LLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTL---- 464
+ ++Y ++ +Y+ +V D+ +GA +KV S++ + GT+ P+ +
Sbjct: 1212 VGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE-NYEGTMDPSQVPEHW 1270
Query: 465 --QGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQP 522
+G +K D+ Y N +PVLK + ++PG+ + G GSGKS+++ +
Sbjct: 1271 PQEGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDI 1329
Query: 523 TGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQA 582
G++++D IS+ L S++ + Q+P+LFSGS+R N+ + C DD++ A +
Sbjct: 1330 FDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEI 1388
Query: 583 AHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
A + ++ + G+ V E G + GQ+Q +ARA VR +LI+DEAT+++D+ E
Sbjct: 1389 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1448
Query: 643 QALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
LQ + DRTV+ IAHR+ ++ A +LV EG L
Sbjct: 1449 NILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGIL 1488
Score = 84.7 bits (208), Expect = 3e-16
Identities = 54/214 (25%), Positives = 104/214 (48%), Gaps = 10/214 (4%)
Query: 486 LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV----LLDEKPISQYEHCY 541
L + + G++T +VG G GKS++ + Q G+V + + +P +
Sbjct: 652 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 711
Query: 542 LHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVG 601
V Q+P L + +V NI +G + A A I + G T++G
Sbjct: 712 NRYSVAYAAQKPWLLNATVEENITFG-SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 770
Query: 602 EKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQ-----CEQALQDWNSRGDRTV 656
E+G L+ GQ+QR+ +ARAL ++ ++ LD+ SALD+ ++ + + RT+
Sbjct: 771 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 830
Query: 657 LVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQ 690
+++ H+LQ + A I+ +++G + + L++ Q
Sbjct: 831 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 864
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 161 bits (407), Expect = 2e-39
Identities = 147/580 (25%), Positives = 267/580 (46%), Gaps = 36/580 (6%)
Query: 125 QEKEQDQVNNKVLMWRLLKLSRPDLP------LLVAAFFFLVLAVLGETLIPHYSGRVID 178
+E+E+D+ +N + RL R +P L + FFL++ ++ L+ H ID
Sbjct: 957 EEEEEDEDDNMSTVMRL----RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAID 1012
Query: 179 ILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLR---------IREQL 229
+ + + + S C G F ++ + + + L
Sbjct: 1013 YWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNL 1072
Query: 230 FSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSIS 289
+ ++ + FF T G + +R S+DT ++ +P L RS + + G M+S +
Sbjct: 1073 LNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG-MISYA 1131
Query: 290 PRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQV-VREAVGGLQTVRSFGAE 348
+ L++LL + + Y + L+E+ D+ E GL T+R+F E
Sbjct: 1132 TPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHE 1191
Query: 349 EHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGS 408
R E + Y L A L R +LG ++L+ + + G G
Sbjct: 1192 TRFKQRMLELTDTNNIAYLF--LSAANRWLEVRTDYLGA-CIVLTASIASIS-GSSNSGL 1247
Query: 409 LLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTL---- 464
+ ++Y ++ +Y+ +V D+ +GA +KV S++ + GT+ P+ +
Sbjct: 1248 VGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE-NYEGTMDPSQVPEHW 1306
Query: 465 --QGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQP 522
+G +K D+ Y N +PVLK + ++PG+ + G GSGKS+++ +
Sbjct: 1307 PQEGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDI 1365
Query: 523 TGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQA 582
G++++D IS+ L S++ + Q+P+LFSGS+R N+ + C DD++ A +
Sbjct: 1366 FDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEI 1424
Query: 583 AHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
A + ++ + G+ V E G + GQ+Q +ARA VR +LI+DEAT+++D+ E
Sbjct: 1425 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1484
Query: 643 QALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
LQ + DRTV+ IAHR+ ++ A +LV EG L
Sbjct: 1485 NILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGIL 1524
Score = 84.7 bits (208), Expect = 3e-16
Identities = 54/214 (25%), Positives = 104/214 (48%), Gaps = 10/214 (4%)
Query: 486 LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV----LLDEKPISQYEHCY 541
L + + G++T +VG G GKS++ + Q G+V + + +P +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 542 LHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVG 601
V Q+P L + +V NI +G + A A I + G T++G
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFG-SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
Query: 602 EKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQ-----CEQALQDWNSRGDRTV 656
E+G L+ GQ+QR+ +ARAL ++ ++ LD+ SALD+ ++ + + RT+
Sbjct: 807 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
Query: 657 LVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQ 690
+++ H+LQ + A I+ +++G + + L++ Q
Sbjct: 867 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 159 bits (403), Expect = 6e-39
Identities = 144/580 (24%), Positives = 267/580 (46%), Gaps = 36/580 (6%)
Query: 125 QEKEQDQVNNKVLMWRLLKLSRPDLP------LLVAAFFFLVLAVLGETLIPHYSGRVID 178
+E+E+D+ +N + RL R +P L + FFL++ ++ L+ H ID
Sbjct: 957 EEEEEDEDDNMSTVMRL----RTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAID 1012
Query: 179 ILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLR---------IREQL 229
+ + + + S C G F ++ + + + L
Sbjct: 1013 YWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNL 1072
Query: 230 FSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSIS 289
+ ++ + FF T G + +R S+DT ++ +P L RS + + G M+S +
Sbjct: 1073 LNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG-MISYA 1131
Query: 290 PRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQV-VREAVGGLQTVRSFGAE 348
+ L++LL + + Y + L+E+ D+ E GL T+R+F E
Sbjct: 1132 TPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHE 1191
Query: 349 EHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGS 408
R E + Y L A L R +LG ++L+ + + G G
Sbjct: 1192 TRFKQRMLELTDTNNIAYLF--LSAANRWLEVRTDYLGA-CIVLTASIASIS-GSSNSGL 1247
Query: 409 LLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTL---- 464
+ ++Y ++ +Y+ +V D+ +GA +KV S++ + GT+ P+ +
Sbjct: 1248 VGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESE-NYEGTMDPSQVPEHW 1306
Query: 465 --QGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQP 522
+G +K D+ Y N +PVLK + ++PG+ + G GSGKS+++ +
Sbjct: 1307 PQEGEIKIHDLCVRYENNL-KPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDI 1365
Query: 523 TGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQA 582
G++++D IS+ L S++ + Q+P+LFSGS+R N+ + C DD++ A +
Sbjct: 1366 FDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK-CTDDRLWEALEI 1424
Query: 583 AHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
A + ++ + G+ V E G + GQ+Q +ARA VR +LI+DEAT+++D+ E
Sbjct: 1425 AQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE 1484
Query: 643 QALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
LQ + DRTV+ IAHR+ + A ++V++ G +
Sbjct: 1485 NILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNI 1524
Score = 84.7 bits (208), Expect = 3e-16
Identities = 54/214 (25%), Positives = 104/214 (48%), Gaps = 10/214 (4%)
Query: 486 LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV----LLDEKPISQYEHCY 541
L + + G++T +VG G GKS++ + Q G+V + + +P +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 542 LHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVG 601
V Q+P L + +V NI +G + A A I + G T++G
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFG-SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIG 806
Query: 602 EKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQ-----CEQALQDWNSRGDRTV 656
E+G L+ GQ+QR+ +ARAL ++ ++ LD+ SALD+ ++ + + RT+
Sbjct: 807 ERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTL 866
Query: 657 LVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQ 690
+++ H+LQ + A I+ +++G + + L++ Q
Sbjct: 867 VLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ 900
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 155 bits (391), Expect = 2e-37
Identities = 115/473 (24%), Positives = 229/473 (48%), Gaps = 17/473 (3%)
Query: 225 IREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGF 284
+ +QL +++LR + FF T TG + +R + D + + + LP + + + ++
Sbjct: 1056 LHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVM 1115
Query: 285 MLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAG--QVVREAVGGLQTV 342
+ +P T++ + ++ + Y + +++ R D+V R+ E V GL +
Sbjct: 1116 ICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRR--LDSVTRSPIYSHFSETVSGLPVI 1173
Query: 343 RSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDG 402
R+F + ++ E Q + +L +R L L + + L +
Sbjct: 1174 RAF-EHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIR--LELVGNLTVFFSALMMVIYR 1230
Query: 403 ELTQGSLLSFMIYQE-SVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAP 461
+ G + F++ ++ + LV + ++ +N+ A E++ Y + P P
Sbjct: 1231 DTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRP 1290
Query: 462 TT---LQGVVKFQDVSFAYPNRPDRP-VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 517
+G ++F + Y RP+ VL+G+T + E +VG G+GKS++ L
Sbjct: 1291 PPDWPSKGKIQFNNYQVRY--RPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLF 1348
Query: 518 NLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVM 577
+ + GGQ+++D I+ L ++ + Q+P+LFSGS+R N+ + D+++
Sbjct: 1349 RILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLD-PFNNYSDEEIW 1407
Query: 578 AAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSAL 637
A + AH F+ ++ G+ +V E G L+ GQ+Q L + RAL+R ++L+LDEAT+A+
Sbjct: 1408 KALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAV 1467
Query: 638 DVQCEQALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
D++ + +Q N TV+ IAHRL + + +++VL GK+ + +E
Sbjct: 1468 DLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEE 1520
Score = 73.6 bits (179), Expect = 6e-13
Identities = 53/219 (24%), Positives = 106/219 (48%), Gaps = 22/219 (10%)
Query: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKST-VAALLQNLYQPTGGQ 526
++F + SF + + + V + + + G++ A++GP GSGKS+ ++A+L + G
Sbjct: 637 MQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHG-- 693
Query: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHAD 586
H + V Q+ + +G++++NI +G + E A
Sbjct: 694 ------------HITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLP 741
Query: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQC----- 641
D ++ + G ++GEKG L+ GQKQR+++ARA ++ + +LD+ SA+D
Sbjct: 742 D-LEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIF 800
Query: 642 EQALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
+ L +T L++ H + + + +I+VL G +
Sbjct: 801 NKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTI 839
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 154 bits (389), Expect = 3e-37
Identities = 119/466 (25%), Positives = 233/466 (50%), Gaps = 22/466 (4%)
Query: 229 LFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSI 288
L S+LR + FF+ T +G L +R S + + + +P + + SL V+G +L
Sbjct: 996 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1055
Query: 289 SPRLTL----LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRS 344
+P + L L++ F + V ++R + L + + + E + G+ +R+
Sbjct: 1056 TPIAAIIIPPLGLIY--FFVQRFYVASSRQLKRLESVSRSPVYSH--FNETLLGVSVIRA 1111
Query: 345 FGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGEL 404
F +E + + +++ ++ Y+ + A L R+ +G +++ + + L
Sbjct: 1112 FEEQERFIHQSDLKVDENQKAYYPSIV--ANRWLAVRLECVGNCIVLFAALFAVISRHSL 1169
Query: 405 TQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP------SPGT 458
+ G + + Y V +Y+ LV + +M +N+ A E++ Y + + P +P +
Sbjct: 1170 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1229
Query: 459 LAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 518
P G V+F++ Y D VL+ + T+ GE +VG G+GKS++ L
Sbjct: 1230 SWPQV--GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1286
Query: 519 LYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMA 578
+ + G++++D I++ L ++ + Q+PVLFSGS+R N+ D++V
Sbjct: 1287 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWT 1345
Query: 579 AAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD 638
+ + AH DF+ + + + E G L+ GQ+Q + +ARAL+R ++L+LDEAT+A+D
Sbjct: 1346 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1405
Query: 639 VQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
++ + +Q D TVL IAHRL + +++VL +G++Q+
Sbjct: 1406 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQE 1451
Score = 48.5 bits (114), Expect = 2e-05
Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 16/125 (12%)
Query: 480 RPDRPVLKGLTFTLRPGEVTALVGPNGSGKST-VAALLQNLYQPTGGQVLLDEKPISQYE 538
R D P L G+TF++ G + A+VG G GKS+ ++ALL + + G
Sbjct: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG-------------- 700
Query: 539 HCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYT 598
H + V V Q+ + + S+R NI +G Q E+ + QA ++ + G T
Sbjct: 701 HVAIKGSVAYVPQQAWIQNDSLRENILFGCQ-LEEPYYRSVIQACALLPDLEILPSGDRT 759
Query: 599 DVGEK 603
++GEK
Sbjct: 760 EIGEK 764
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 154 bits (389), Expect = 3e-37
Identities = 119/466 (25%), Positives = 233/466 (50%), Gaps = 22/466 (4%)
Query: 229 LFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSI 288
L S+LR + FF+ T +G L +R S + + + +P + + SL V+G +L
Sbjct: 937 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 996
Query: 289 SPRLTL----LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRS 344
+P + L L++ F + V ++R + L + + + E + G+ +R+
Sbjct: 997 TPIAAIIIPPLGLIY--FFVQRFYVASSRQLKRLESVSRSPVYSH--FNETLLGVSVIRA 1052
Query: 345 FGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGEL 404
F +E + + +++ ++ Y+ + A L R+ +G +++ + + L
Sbjct: 1053 FEEQERFIHQSDLKVDENQKAYYPSIV--ANRWLAVRLECVGNCIVLFAALFAVISRHSL 1110
Query: 405 TQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP------SPGT 458
+ G + + Y V +Y+ LV + +M +N+ A E++ Y + + P +P +
Sbjct: 1111 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1170
Query: 459 LAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 518
P G V+F++ Y D VL+ + T+ GE +VG G+GKS++ L
Sbjct: 1171 SWPQV--GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1227
Query: 519 LYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMA 578
+ + G++++D I++ L ++ + Q+PVLFSGS+R N+ D++V
Sbjct: 1228 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWT 1286
Query: 579 AAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD 638
+ + AH DF+ + + + E G L+ GQ+Q + +ARAL+R ++L+LDEAT+A+D
Sbjct: 1287 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1346
Query: 639 VQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
++ + +Q D TVL IAHRL + +++VL +G++Q+
Sbjct: 1347 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQE 1392
Score = 37.7 bits (86), Expect = 0.037
Identities = 20/63 (31%), Positives = 32/63 (50%)
Query: 480 RPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEH 539
R D P L G+TF++ G + A+VG G GKS++ + L G V + + + +
Sbjct: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSM 714
Query: 540 CYL 542
YL
Sbjct: 715 SYL 717
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 154 bits (389), Expect = 3e-37
Identities = 119/466 (25%), Positives = 233/466 (50%), Gaps = 22/466 (4%)
Query: 229 LFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSI 288
L S+LR + FF+ T +G L +R S + + + +P + + SL V+G +L
Sbjct: 993 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1052
Query: 289 SPRLTL----LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRS 344
+P + L L++ F + V ++R + L + + + E + G+ +R+
Sbjct: 1053 TPIAAIIIPPLGLIY--FFVQRFYVASSRQLKRLESVSRSPVYSH--FNETLLGVSVIRA 1108
Query: 345 FGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGEL 404
F +E + + +++ ++ Y+ + A L R+ +G +++ + + L
Sbjct: 1109 FEEQERFIHQSDLKVDENQKAYYPSIV--ANRWLAVRLECVGNCIVLFAALFAVISRHSL 1166
Query: 405 TQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP------SPGT 458
+ G + + Y V +Y+ LV + +M +N+ A E++ Y + + P +P +
Sbjct: 1167 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1226
Query: 459 LAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 518
P G V+F++ Y D VL+ + T+ GE +VG G+GKS++ L
Sbjct: 1227 SWPQV--GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1283
Query: 519 LYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMA 578
+ + G++++D I++ L ++ + Q+PVLFSGS+R N+ D++V
Sbjct: 1284 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWT 1342
Query: 579 AAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD 638
+ + AH DF+ + + + E G L+ GQ+Q + +ARAL+R ++L+LDEAT+A+D
Sbjct: 1343 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1402
Query: 639 VQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
++ + +Q D TVL IAHRL + +++VL +G++Q+
Sbjct: 1403 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQE 1448
Score = 47.0 bits (110), Expect = 6e-05
Identities = 25/94 (26%), Positives = 49/94 (52%), Gaps = 5/94 (5%)
Query: 600 VGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQC-----EQALQDWNSRGDR 654
V KG L+ GQKQR+++ARA+ + + + D+ SA+D E + ++
Sbjct: 702 VAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNK 761
Query: 655 TVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
T +++ H + + + I+V+ GK+ ++ QE
Sbjct: 762 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 795
Score = 35.4 bits (80), Expect = 0.18
Identities = 16/37 (43%), Positives = 24/37 (64%)
Query: 480 RPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALL 516
R D P L G+TF++ G + A+VG G GKS++ + L
Sbjct: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSAL 691
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 154 bits (389), Expect = 3e-37
Identities = 119/466 (25%), Positives = 233/466 (50%), Gaps = 22/466 (4%)
Query: 229 LFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSI 288
L S+LR + FF+ T +G L +R S + + + +P + + SL V+G +L
Sbjct: 1052 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1111
Query: 289 SPRLTL----LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRS 344
+P + L L++ F + V ++R + L + + + E + G+ +R+
Sbjct: 1112 TPIAAIIIPPLGLIY--FFVQRFYVASSRQLKRLESVSRSPVYSH--FNETLLGVSVIRA 1167
Query: 345 FGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGEL 404
F +E + + +++ ++ Y+ + A L R+ +G +++ + + L
Sbjct: 1168 FEEQERFIHQSDLKVDENQKAYYPSIV--ANRWLAVRLECVGNCIVLFAALFAVISRHSL 1225
Query: 405 TQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP------SPGT 458
+ G + + Y V +Y+ LV + +M +N+ A E++ Y + + P +P +
Sbjct: 1226 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1285
Query: 459 LAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 518
P G V+F++ Y D VL+ + T+ GE +VG G+GKS++ L
Sbjct: 1286 SWPQV--GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1342
Query: 519 LYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMA 578
+ + G++++D I++ L ++ + Q+PVLFSGS+R N+ D++V
Sbjct: 1343 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWT 1401
Query: 579 AAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD 638
+ + AH DF+ + + + E G L+ GQ+Q + +ARAL+R ++L+LDEAT+A+D
Sbjct: 1402 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1461
Query: 639 VQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
++ + +Q D TVL IAHRL + +++VL +G++Q+
Sbjct: 1462 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQE 1507
Score = 88.6 bits (218), Expect = 2e-17
Identities = 60/215 (27%), Positives = 107/215 (49%), Gaps = 21/215 (9%)
Query: 480 RPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTV-AALLQNLYQPTGGQVLLDEKPISQYE 538
R D P L G+TF++ G + A+VG G GKS++ +ALL + + G
Sbjct: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG-------------- 700
Query: 539 HCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYT 598
H + V V Q+ + + S+R NI +G Q E+ + QA ++ + G T
Sbjct: 701 HVAIKGSVAYVPQQAWIQNDSLRENILFGCQ-LEEPYYRSVIQACALLPDLEILPSGDRT 759
Query: 599 DVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQC-----EQALQDWNSRGD 653
++GEKG L+ GQKQR+++ARA+ + + + D+ SA+D E + +
Sbjct: 760 EIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKN 819
Query: 654 RTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
+T +++ H + + + I+V+ GK+ ++ QE
Sbjct: 820 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQE 854
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 154 bits (389), Expect = 3e-37
Identities = 141/540 (26%), Positives = 262/540 (48%), Gaps = 37/540 (6%)
Query: 180 LGGDFDPHAFASAIFFM--CLFSFG--SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLR 235
+GG A IF + CL + G +S++A GG +R + + ++L ++R
Sbjct: 786 VGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVR 839
Query: 236 QDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLL 295
+ FF+ T G L +R S +T + +P + L L+ GL L ++ L
Sbjct: 840 SPISFFERTPIGHLLNRFSKETDTVDVDIP---DKLRSLLMYAFGLLEVSLVVAVATPLA 896
Query: 296 SLLHMPFTI---AAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEV 352
++ +P + + +Y ++ R + + + E G VR+F + V
Sbjct: 897 TVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFV 956
Query: 353 CRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSF 412
+ +++ +++ + R + A L V LG ++ + + L+ G L+ F
Sbjct: 957 AQNNARVDESQRISFPRLV--ADRWLAANVELLGNGLVFAAATCAVLSKAHLSAG-LVGF 1013
Query: 413 MIYQE-SVGSYVQTLVYIYGDMLSNVGAAEKVFSYM----DRQPNLPSPGTLAPTTLQGV 467
+ V +Q +V + D+ +++ + E++ Y + LP+ P G
Sbjct: 1014 SVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQ 1073
Query: 468 VKFQDVSFAYPNRPDRPV-LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 526
++FQD Y RP+ P+ ++G++F + GE +VG G+GKS++A+ L L + G
Sbjct: 1074 IEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGG 1131
Query: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHAD 586
+ +D PI+ L S++ + Q+P+LF GS+R N+ LQ D+ + AA +
Sbjct: 1132 IWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLK 1190
Query: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD----VQCE 642
+ + + ++G L+ GQKQ L +ARAL+R ++LILDEAT+A+D +Q +
Sbjct: 1191 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1250
Query: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQEGQDLYSRLVQQ 699
L W ++ TVL+IAHRL++V ++LV+ +G++ + AQL + L+ RL Q+
Sbjct: 1251 AMLGSWFAQ--CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1308
Score = 84.3 bits (207), Expect = 3e-16
Identities = 62/226 (27%), Positives = 105/226 (46%), Gaps = 20/226 (8%)
Query: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
+ Q +FA+ ++ P L + T+ G + A+VGP G+GKS++ + L G V
Sbjct: 438 ITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV 496
Query: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
++ V V QE + + SV N+ +G Q + + +A
Sbjct: 497 SIE-------------GAVAYVPQEAWVQNTSVVENVCFG-QELDPPWLERVLEACALQP 542
Query: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQC-----E 642
+ GI+T +GE+G L+ GQKQRL++ARA+ R V +LD+ +ALD
Sbjct: 543 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 602
Query: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
Q + T +++ H L + +A I+VL G + ++ QE
Sbjct: 603 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 648
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 152 bits (385), Expect = 8e-37
Identities = 140/540 (25%), Positives = 262/540 (48%), Gaps = 37/540 (6%)
Query: 180 LGGDFDPHAFASAIFFM--CLFSFG--SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLR 235
+GG A IF + CL + G +S++A GG +R + + ++L ++R
Sbjct: 977 VGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVR 1030
Query: 236 QDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLL 295
+ FF+ T G L +R S +T + +P + L L+ GL L ++ L
Sbjct: 1031 SPISFFERTPIGHLLNRFSKETDTVDVDIP---DKLRSLLMYAFGLLEVSLVVAVATPLA 1087
Query: 296 SLLHMPFTI---AAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEV 352
++ +P + + +Y ++ R + + + E G VR+F + V
Sbjct: 1088 TVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFV 1147
Query: 353 CRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSF 412
+ +++ +++ + R + A L V LG ++ + + L+ G L+ F
Sbjct: 1148 AQNNARVDESQRISFPRLV--ADRWLAANVELLGNGLVFAAATCAVLSKAHLSAG-LVGF 1204
Query: 413 MIYQE-SVGSYVQTLVYIYGDMLSNVGAAEKVFSYM----DRQPNLPSPGTLAPTTLQGV 467
+ V +Q +V + D+ +++ + E++ Y + LP+ P G
Sbjct: 1205 SVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQ 1264
Query: 468 VKFQDVSFAYPNRPDRPV-LKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 526
++F+D Y RP+ P+ ++G++F + GE +VG G+GKS++A+ L L + G
Sbjct: 1265 IEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGG 1322
Query: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHAD 586
+ +D PI+ L S++ + Q+P+LF GS+R N+ LQ D+ + AA +
Sbjct: 1323 IWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLK 1381
Query: 587 DFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD----VQCE 642
+ + + ++G L+ GQKQ L +ARAL+R ++LILDEAT+A+D +Q +
Sbjct: 1382 ALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQ 1441
Query: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKL---AQLQEGQDLYSRLVQQ 699
L W ++ TVL+IAHRL++V ++LV+ +G++ + AQL + L+ RL Q+
Sbjct: 1442 AMLGSWFAQ--CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQE 1499
Score = 82.4 bits (202), Expect = 1e-15
Identities = 61/226 (26%), Positives = 104/226 (46%), Gaps = 20/226 (8%)
Query: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
+ +FA+ ++ P L + T+ G + A+VGP G+GKS++ + L G V
Sbjct: 629 ITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFV 687
Query: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
++ V V QE + + SV N+ +G Q + + +A
Sbjct: 688 SIE-------------GAVAYVPQEAWVQNTSVVENVCFG-QELDPPWLERVLEACALQP 733
Query: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQC-----E 642
+ GI+T +GE+G L+ GQKQRL++ARA+ R V +LD+ +ALD
Sbjct: 734 DVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFN 793
Query: 643 QALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQE 688
Q + T +++ H L + +A I+VL G + ++ QE
Sbjct: 794 QVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQE 839
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 148 bits (373), Expect = 2e-35
Identities = 121/482 (25%), Positives = 226/482 (46%), Gaps = 29/482 (6%)
Query: 216 YTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSL 275
+T ++ R+ L + ++ + FF+ T G + +R SSD + +P L RS
Sbjct: 1087 WTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRST 1146
Query: 276 VKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAG-QVVRE 334
+ V + ++P + L++LL + + Y L+++ D E
Sbjct: 1147 LLCVSALAVISYVTP-VFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAE 1205
Query: 335 AVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYL------LVRRVLHLGVQ 388
V GL T+R+F RY+ +Q Y + +L+L L R+ ++G
Sbjct: 1206 TVEGLTTIRAF--------RYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGAC 1257
Query: 389 MLMLSC--GLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSY 446
+++++ + EL+ G + + Y V +Y+ +V DM +GA +++
Sbjct: 1258 VVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGL 1317
Query: 447 MDRQPNLPSPGTLAPTTL------QGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTA 500
+ + G LAP+ + QG ++ Q++S Y + +PVLK + + PG+
Sbjct: 1318 LKTEAE-SYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSL-KPVLKHVNALIAPGQKIG 1375
Query: 501 LVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSV 560
+ G GSGKS+ + + G +++D I++ L S++ + Q+PVLFSG++
Sbjct: 1376 ICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTI 1435
Query: 561 RNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARA 620
R N+ + C D + A + A ++ + G+ + E G + GQ+Q +ARA
Sbjct: 1436 RFNLD-PERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARA 1494
Query: 621 LVRDPRVLILDEATSALDVQCEQALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEG 678
VR + I+DEAT+++D+ E LQ + DRTV+ IAHR+ + A ++VL+ G
Sbjct: 1495 FVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRG 1554
Query: 679 KL 680
+
Sbjct: 1555 AI 1556
Score = 87.4 bits (215), Expect = 4e-17
Identities = 62/225 (27%), Positives = 101/225 (44%), Gaps = 19/225 (8%)
Query: 484 PVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEH---- 539
P L +T + G++T +VG G GKS++ Q G V P S+
Sbjct: 694 PTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSP 753
Query: 540 ---------CYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQ 590
V Q+P L + +V NI + + +A I
Sbjct: 754 ERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFE-SPFNKQRYKMVIEACSLQPDID 812
Query: 591 EMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWN- 649
+ HG T +GE+G L+ GQ+QR+++ARAL + V+ LD+ SALD+ L
Sbjct: 813 ILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGI 872
Query: 650 ---SRGD-RTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEGQ 690
R D RTV+++ H+LQ + A I+ +++G +Q+ L++ Q
Sbjct: 873 LELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQ 917
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 147 bits (370), Expect = 4e-35
Identities = 124/497 (24%), Positives = 245/497 (49%), Gaps = 22/497 (4%)
Query: 216 YTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSL 275
Y + + + ++F S+L+ + FF G + +R S D + + LPL +++L
Sbjct: 788 YVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTL 847
Query: 276 VKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREA 335
++VVG+ +++ P + + + I + + ++V R + + +
Sbjct: 848 LQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSS 907
Query: 336 VGGLQTVRSFGAEEHEVCRYKEALEQCRQLY---WRRDLERALYLLVRRVLHLGVQMLML 392
+ GL T+R++ AEE R +E + + L+ W L + + VR + ++++
Sbjct: 908 LQGLWTIRAYKAEE----RCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIV 963
Query: 393 SCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPN 452
+ G + L G + + Y ++ Q V ++ + + + E+V Y D +
Sbjct: 964 AFGSLILAK-TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKE 1022
Query: 453 LPSPGTLAPTTL---QGVVKFQDVSFAYPNRPDRP-VLKGLTFTLRPGEVTALVGPNGSG 508
P P +GV+ F +V+F Y P P VLK LT ++ E +VG G+G
Sbjct: 1023 APWEYQKRPPPAWPHEGVIIFDNVNFMYS--PGGPLVLKHLTALIKSQEKVGIVGRTGAG 1080
Query: 509 KSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL 568
KS++ + L L +P G ++ +D+ ++ L ++ + QEPVLF+G++R N+
Sbjct: 1081 KSSLISALFRLSEPEG-KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD-PF 1138
Query: 569 QSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVL 628
D+++ A Q + I+++ + T++ E GS + GQ+Q + +ARA++R ++L
Sbjct: 1139 NEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQIL 1198
Query: 629 ILDEATSALDVQCEQALQD--WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQ- 685
I+DEAT+ +D + ++ +Q TVL IAHRL + + +I+VL G+L++ +
Sbjct: 1199 IIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEP 1258
Query: 686 ---LQEGQDLYSRLVQQ 699
LQ + L+ ++VQQ
Sbjct: 1259 YVLLQNKESLFYKMVQQ 1275
Score = 121 bits (303), Expect = 3e-27
Identities = 73/235 (31%), Positives = 132/235 (56%), Gaps = 24/235 (10%)
Query: 449 RQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSG 508
R LPS G + +V QD + + + P L+GL+FT+RPGE+ A+VGP G+G
Sbjct: 398 RNRQLPSDG-------KKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAG 450
Query: 509 KSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL 568
KS++ + + P+ G V +H ++ V Q+P +FSG++R+NI +G
Sbjct: 451 KSSLLSAVLGELAPSHGLV-------------SVHGRIAYVSQQPWVFSGTLRSNILFG- 496
Query: 569 QSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVL 628
+ E ++ +A +Q +E G T +G++G+ L+ GQK R+ +ARA+ +D +
Sbjct: 497 KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIY 556
Query: 629 ILDEATSALDVQCEQALQD---WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKL 680
+LD+ SA+D + + L + ++ +++ H+LQ ++ A QIL+L++GK+
Sbjct: 557 LLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKM 611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,494,549
Number of Sequences: 37866
Number of extensions: 1117030
Number of successful extensions: 3484
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 3121
Number of HSP's gapped (non-prelim): 191
length of query: 703
length of database: 18,247,518
effective HSP length: 109
effective length of query: 594
effective length of database: 14,120,124
effective search space: 8387353656
effective search space used: 8387353656
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.