Search of human proteins with 73747889

Search of human proteins with 73747889

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|73747889 a disintegrin and metalloprotease domain 17
preproprotein [Homo sapiens]
         (824 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|73747889 a disintegrin and metalloprotease domain 17 prepropr...  1712   0.0  
gi|4557251 ADAM metallopeptidase domain 10 [Homo sapiens]             254   2e-67
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ...   115   1e-25
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro...   111   2e-24
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop...   111   2e-24
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]   105   2e-22
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor...   104   4e-22
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor...   104   4e-22
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor...   104   4e-22
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor...   104   4e-22
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor...   104   4e-22
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor...   104   4e-22
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H...   102   1e-21
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot...   101   2e-21
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot...   101   2e-21
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo...    99   1e-20
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo...    99   1e-20
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo...    99   1e-20
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ...    99   1e-20
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s...    98   3e-20
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot...    91   6e-18
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot...    91   6e-18
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot...    91   6e-18
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot...    91   6e-18
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote...    91   6e-18
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ...    87   5e-17
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi...    87   6e-17
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s...    86   1e-16
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ...    86   2e-16
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ...    83   1e-15

>gi|73747889 a disintegrin and metalloprotease domain 17
           preproprotein [Homo sapiens]
          Length = 824

 Score = 1712 bits (4433), Expect = 0.0
 Identities = 824/824 (100%), Positives = 824/824 (100%)

Query: 1   MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL 60
           MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
Sbjct: 1   MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL 60

Query: 61  QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV 120
           QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV
Sbjct: 61  QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV 120

Query: 121 GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS 180
           GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
Sbjct: 121 GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS 180

Query: 181 PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG 240
           PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
Sbjct: 181 PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG 240

Query: 241 RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM 300
           RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM
Sbjct: 241 RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM 300

Query: 301 AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS 360
           AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
Sbjct: 301 AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS 360

Query: 361 HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL 420
           HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
Sbjct: 361 HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL 420

Query: 421 AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN 480
           AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
Sbjct: 421 AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN 480

Query: 481 SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA 540
           SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
Sbjct: 481 SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA 540

Query: 541 TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC 600
           TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC
Sbjct: 541 TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC 600

Query: 601 KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS 660
           KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
Sbjct: 601 KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS 660

Query: 661 INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD 720
           INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
Sbjct: 661 INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD 720

Query: 721 SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD 780
           SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD
Sbjct: 721 SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD 780

Query: 781 PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC 824
           PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
Sbjct: 781 PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC 824


>gi|4557251 ADAM metallopeptidase domain 10 [Homo sapiens]
          Length = 748

 Score =  254 bits (650), Expect = 2e-67
 Identities = 190/648 (29%), Positives = 290/648 (44%), Gaps = 68/648 (10%)

Query: 35  LDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLT--FSALKRHFKLYLTSSTERFSQ 92
           L+  +  Y+ LS +    H   +R  +  +H +  L   F A  RHF L +   T  FS 
Sbjct: 25  LNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGRHFNLRMKRDTSLFSD 84

Query: 93  NFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPL 152
            FKV   +   + + +      +TGH+ GE  S     + D      I T G  + +EP 
Sbjct: 85  EFKVETSNKVLDYDTS----HIYTGHIYGEEGSFSHGSVIDGRFEGFIQTRGGTFYVEPA 140

Query: 153 WRFVND-TKDKRMLVYKSEDIKNVSRLQSPKVCG----YLKVDNEELLPKGLVDREPPEE 207
            R++ D T     ++Y  +DI    +      C     + ++   ++     V + P EE
Sbjct: 141 ERYIKDRTLPFHSVIYHEDDINYPHKYGPQGGCADHSVFERMRKYQMTGVEEVTQIPQEE 200

Query: 208 LVHR----VKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYR 263
                   ++++      KNTC+L +  DH F++Y G  E       +   +  +D IY+
Sbjct: 201 HAANGPELLRKKRTTSAEKNTCQLYIQTDHLFFKYYGTRE--AVIAQISSHVKAIDTIYQ 258

Query: 264 NTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSF 323
            T  D +G +     +++IRI  +  E  P          +PN       V+  LE  S 
Sbjct: 259 TT--DFSGIRNISFMVKRIRINTTADEKDPTNPF-----RFPNI-----GVEKFLELNS- 305

Query: 324 DIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSG 383
              +     CLA++FT +DFD G LGLA+VG+P  +S GG+C K+     GKK   LN+G
Sbjct: 306 --EQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSS-GGICEKSKLYSDGKKKS-LNTG 361

Query: 384 LTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNED------QGGKYVMYP 437
           + + +NYG  +  K + +   HE+GHNFG+ HD     EC P E       + G Y+MY 
Sbjct: 362 IITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSG--TECTPGESKNLGQKENGNYIMYA 419

Query: 438 IAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLN 497
            A SGD  NN  FS CS ++I + +E K   CF E    +CGN  V++GEECD G     
Sbjct: 420 RATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQC 479

Query: 498 NDTCC-------NSDCTLKEGVQCSDRNSPCC-KNCQFETAQKKCQEAINATCKGVSYCT 549
            D CC          C LK G QCS    PCC   C F++  +KC++  ++ C     C 
Sbjct: 480 KDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCAFKSKSEKCRD--DSDCAREGICN 537

Query: 550 GNSSECPPPGNAEDDTVC-LDLGKCKDGKCIPFCEREQQLESCACNETDNS-----CKVC 603
           G ++ CP      + T C      C +G+C      +  LE C C  +D       C VC
Sbjct: 538 GFTALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKYGLEECTCASSDGKDDKELCHVC 597

Query: 604 C-RDLSGRCVPYVDAEQ-------KNLFLRKGKPCT--VGFCDMNGKC 641
           C + +         + Q       + + L+ G PC    G+CD+  +C
Sbjct: 598 CMKKMDPSTCASTGSVQWSRHFSGRTITLQPGSPCNDFRGYCDVFMRC 645


>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
           sapiens]
          Length = 918

 Score =  115 bits (289), Expect = 1e-25
 Identities = 162/635 (25%), Positives = 261/635 (41%), Gaps = 105/635 (16%)

Query: 16  LAPRPPDDPGF--GPHQRLEKLD-SLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTF 72
           L PR   +PG+  G  +   KL   L+      S S +++    K +L+       L+  
Sbjct: 20  LRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELIL- 78

Query: 73  SALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQD--FFTGHV-VGEPDSRVLA 129
             L+++ +L+  S TE              N    T K +D  F+ G V   E  S  L+
Sbjct: 79  -DLEKNEQLFAPSYTETH-------YTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLS 130

Query: 130 HIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKV 189
             R    +I ++++   Y IEPL     D+K +  L+Y+SE +K       P  CG+ + 
Sbjct: 131 TCRGIRGLITVSSN-LSYVIEPL----PDSKGQH-LIYRSEHLK-----PPPGNCGF-EH 178

Query: 190 DNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTN 249
                    L   +  ++   R+KR  D + MK   +L +VAD+  ++   R ++  T +
Sbjct: 179 SKPTTRDWALQFTQQTKKRPRRMKRE-DLNSMKYV-ELYLVADYLEFQ-KNRRDQDATKH 235

Query: 250 YLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEK 309
            LIE+ + VD  YR+ +               IRI     EV     H NM +   N   
Sbjct: 236 KLIEIANYVDKFYRSLN---------------IRIALVGLEVWT---HGNMCEVSENPYS 277

Query: 310 DAWDV----KMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVC 365
             W      + LL Q   D A+         L T   F   T+GLA + +        +C
Sbjct: 278 TLWSFLSWRRKLLAQKYHDNAQ---------LITGMSFHGTTIGLAPLMA--------MC 320

Query: 366 PKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAP 425
                      ++Y + G+    ++ +  +   A +   HE+GHNFG  HD    A+C  
Sbjct: 321 -----------SVYQSGGVNM--DHSENAIGVAATMA--HEMGHNFGMTHDS---ADCCS 362

Query: 426 NEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSN-------KVC 478
                G  +M   A +  H   K+F+ C+++ + + ++S    C     +       + C
Sbjct: 363 ASAADGGCIM---AAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRC 419

Query: 479 GNSRVDEGEECDPGIMYLNNDTCCN-SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEA 537
           GN  +++GEECD G     N+ CCN S+CTL+ G +C+  +  CC  C+       C+E 
Sbjct: 420 GNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECA--HGSCCHQCKLLAPGTLCREQ 477

Query: 538 INATCKGVSYCTGNSSECPPPGNAEDDTVCL-DLGKCKDGKCIPFCEREQQLESCACNET 596
               C    +CTG S  CP      D T C      C +G C+ + E+ QQL        
Sbjct: 478 AR-QCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPA 536

Query: 597 DNSC--KV-CCRDLSGRCVPYVDAEQKNLFLRKGK 628
            + C  KV    D  G C   ++ E +   +R  K
Sbjct: 537 PDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAK 571


>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
           preproprotein [Homo sapiens]
          Length = 813

 Score =  111 bits (278), Expect = 2e-24
 Identities = 96/318 (30%), Positives = 131/318 (41%), Gaps = 55/318 (17%)

Query: 335 AHLFTYQDFDMGTLGLAYV-GSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKT 393
           A L T + F   T+GLA V G  RA S GGV       P+G                   
Sbjct: 298 AQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIG------------------- 338

Query: 394 ILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNC 453
                A     HE+GH+ G  HDPDG   C     + G  VM   A +  H   ++FS C
Sbjct: 339 -----AAATMAHEIGHSLGLSHDPDGC--CVEAAAESGGCVM---AAATGHPFPRVFSAC 388

Query: 454 SKQSIYKTIESKAQECFQERSN-------KVCGNSRVDEGEECDPGIMYLNNDTCCNS-D 505
           S++ +          C     +        +CGN  V+ GEECD G      D CC + +
Sbjct: 389 SRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHN 448

Query: 506 CTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDT 565
           C+L+ G QC+  +  CC  C  + A   C++A+   C    +CTG SS CPP     D +
Sbjct: 449 CSLRPGAQCA--HGDCCVRCLLKPAGALCRQAM-GDCDLPEFCTGTSSHCPPDVYLLDGS 505

Query: 566 VCL-DLGKCKDGKCIPFCEREQQL---------ESC--ACNETDNSCKVCCRDLSGRCVP 613
            C    G C DG C    ++ QQL         E+C    N   ++   C +D  G  +P
Sbjct: 506 PCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLP 565

Query: 614 YV--DAEQKNLFLRKGKP 629
               DA    L  + GKP
Sbjct: 566 CAGRDALCGKLQCQGGKP 583


>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
           preproprotein [Homo sapiens]
          Length = 787

 Score =  111 bits (278), Expect = 2e-24
 Identities = 96/318 (30%), Positives = 131/318 (41%), Gaps = 55/318 (17%)

Query: 335 AHLFTYQDFDMGTLGLAYV-GSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKT 393
           A L T + F   T+GLA V G  RA S GGV       P+G                   
Sbjct: 298 AQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIG------------------- 338

Query: 394 ILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNC 453
                A     HE+GH+ G  HDPDG   C     + G  VM   A +  H   ++FS C
Sbjct: 339 -----AAATMAHEIGHSLGLSHDPDGC--CVEAAAESGGCVM---AAATGHPFPRVFSAC 388

Query: 454 SKQSIYKTIESKAQECFQERSN-------KVCGNSRVDEGEECDPGIMYLNNDTCCNS-D 505
           S++ +          C     +        +CGN  V+ GEECD G      D CC + +
Sbjct: 389 SRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHN 448

Query: 506 CTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDT 565
           C+L+ G QC+  +  CC  C  + A   C++A+   C    +CTG SS CPP     D +
Sbjct: 449 CSLRPGAQCA--HGDCCVRCLLKPAGALCRQAM-GDCDLPEFCTGTSSHCPPDVYLLDGS 505

Query: 566 VCL-DLGKCKDGKCIPFCEREQQL---------ESC--ACNETDNSCKVCCRDLSGRCVP 613
            C    G C DG C    ++ QQL         E+C    N   ++   C +D  G  +P
Sbjct: 506 PCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLP 565

Query: 614 YV--DAEQKNLFLRKGKP 629
               DA    L  + GKP
Sbjct: 566 CAGRDALCGKLQCQGGKP 583


>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
          Length = 856

 Score =  105 bits (262), Expect = 2e-22
 Identities = 135/542 (24%), Positives = 205/542 (37%), Gaps = 89/542 (16%)

Query: 74  ALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTV--KWQD--FFTGHVVGEPDSRV-L 128
           A   +F L+L  + +     +        N SE T   + QD  F+ GHV G PDS   L
Sbjct: 63  ATGHNFTLHLRKNRDLLGSGYTETYT-AANGSEVTEQPRGQDHCFYQGHVEGYPDSAASL 121

Query: 129 AHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLK 188
           +         ++ +D   + IEPL       +  R  VY++E +     LQ+   CG   
Sbjct: 122 STCAGLRGFFQVGSD--LHLIEPL---DEGGEGGRHAVYQAEHL-----LQTAGTCGVSD 171

Query: 189 VDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNT--CKLLVVADHRFYRYMGRGEEST 246
                LL        P    V R  R  D  P + T   +L VV D+  ++ +G   E+ 
Sbjct: 172 DSLGSLLG-------PRTAAVFR-PRPGDSLPSRETRYVELYVVVDNAEFQMLG--SEAA 221

Query: 247 TTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPN 306
             + ++E+++ VD +Y+  ++      G  I   Q R   SP              S   
Sbjct: 222 VRHRVLEVVNHVDKLYQKLNF-RVVLVGLEIWNSQDRFHVSPDP------------SVTL 268

Query: 307 EEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCP 366
           E    W  +    +   D  +         L T  DF   T+G A V +  ++S G V  
Sbjct: 269 ENLLTWQARQRTRRHLHDNVQ---------LITGVDFTGTTVGFARVSAMCSHSSGAVNQ 319

Query: 367 KAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPN 426
               +PVG                              HE+GHN G +HD +        
Sbjct: 320 DHSKNPVG------------------------VACTMAHEMGHNLGMDHDENVQGCRCQE 355

Query: 427 EDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSN-------KVCG 479
             + G+ +M   A S      +MFS+CS+  +   +E     C     +        VCG
Sbjct: 356 RFEAGRCIM---AGSIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGPVCG 412

Query: 480 NSRVDEGEECDPGIMYLNNDTCCNS-DCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAI 538
           N  V+ GE+CD G      + CCNS  C L EG QC+  +  CC+ C+ + A + C+   
Sbjct: 413 NLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCA--HGTCCQECKVKPAGELCRPK- 469

Query: 539 NATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDN 598
              C    +C G   ECP     E+ T C   G C +G C    ++ Q          + 
Sbjct: 470 KDMCDLEEFCDGRHPECPEDAFQENGTPCSG-GYCYNGACPTLAQQCQAFWGPGGQAAEE 528

Query: 599 SC 600
           SC
Sbjct: 529 SC 530


>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
           preproprotein [Homo sapiens]
          Length = 863

 Score =  104 bits (259), Expect = 4e-22
 Identities = 101/402 (25%), Positives = 158/402 (39%), Gaps = 72/402 (17%)

Query: 202 REPPEELV--HRVKRRADPDPMKNTCKLLVVADH---RFYRYMGRGEESTTTNYLIELID 256
           ++PPE  +    ++RR D      T +L++VADH   + YR     +     N  +E+  
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-----DFQHLLNRTLEVAL 244

Query: 257 RVDDIYR--NTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDV 314
            +D  +R  N      G + +  Q + + I  +P        H+  A   P    D+   
Sbjct: 245 LLDTFFRPLNVRVALVGLEAW-TQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS--- 300

Query: 315 KMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVG 374
                               A L T   F   T+G+A   S        +C   +   V 
Sbjct: 301 --------------------AQLVTGTSFSGPTVGMAIQNS--------ICSPDFSGGVN 332

Query: 375 KKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYV 434
             +     G+ S+                 HELGH+ G +HD  G +   P        +
Sbjct: 333 MDHSTSILGVASS---------------IAHELGHSLGLDHDLPGNSCPCPGPAPAKTCI 377

Query: 435 MYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV------CGNSRVDEGEE 488
           M     S D      FSNCS++++ K +      C  ER   +      CGN  V+ GE+
Sbjct: 378 M---EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQ 434

Query: 489 CDPGIMYLNNDTCCNS-DCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSY 547
           CD G +    D CC+S  C L+ G QC+  + PCC+NCQ   +  +C+      C    +
Sbjct: 435 CDCGFLDDCVDPCCDSLTCQLRPGAQCAS-DGPCCQNCQLRPSGWQCRPT-RGDCDLPEF 492

Query: 548 CTGNSSECPPPGNAEDDTVCL-DLGKCKDGKCIPFCEREQQL 588
           C G+SS+CPP  +  D   C      C  G+C  + ++ Q L
Sbjct: 493 CPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534


>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
           preproprotein [Homo sapiens]
          Length = 862

 Score =  104 bits (259), Expect = 4e-22
 Identities = 101/402 (25%), Positives = 158/402 (39%), Gaps = 72/402 (17%)

Query: 202 REPPEELV--HRVKRRADPDPMKNTCKLLVVADH---RFYRYMGRGEESTTTNYLIELID 256
           ++PPE  +    ++RR D      T +L++VADH   + YR     +     N  +E+  
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-----DFQHLLNRTLEVAL 244

Query: 257 RVDDIYR--NTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDV 314
            +D  +R  N      G + +  Q + + I  +P        H+  A   P    D+   
Sbjct: 245 LLDTFFRPLNVRVALVGLEAW-TQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS--- 300

Query: 315 KMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVG 374
                               A L T   F   T+G+A   S        +C   +   V 
Sbjct: 301 --------------------AQLVTGTSFSGPTVGMAIQNS--------ICSPDFSGGVN 332

Query: 375 KKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYV 434
             +     G+ S+                 HELGH+ G +HD  G +   P        +
Sbjct: 333 MDHSTSILGVASS---------------IAHELGHSLGLDHDLPGNSCPCPGPAPAKTCI 377

Query: 435 MYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV------CGNSRVDEGEE 488
           M     S D      FSNCS++++ K +      C  ER   +      CGN  V+ GE+
Sbjct: 378 M---EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQ 434

Query: 489 CDPGIMYLNNDTCCNS-DCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSY 547
           CD G +    D CC+S  C L+ G QC+  + PCC+NCQ   +  +C+      C    +
Sbjct: 435 CDCGFLDDCVDPCCDSLTCQLRPGAQCAS-DGPCCQNCQLRPSGWQCRPT-RGDCDLPEF 492

Query: 548 CTGNSSECPPPGNAEDDTVCL-DLGKCKDGKCIPFCEREQQL 588
           C G+SS+CPP  +  D   C      C  G+C  + ++ Q L
Sbjct: 493 CPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534


>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
           preproprotein [Homo sapiens]
          Length = 838

 Score =  104 bits (259), Expect = 4e-22
 Identities = 101/402 (25%), Positives = 158/402 (39%), Gaps = 72/402 (17%)

Query: 202 REPPEELV--HRVKRRADPDPMKNTCKLLVVADH---RFYRYMGRGEESTTTNYLIELID 256
           ++PPE  +    ++RR D      T +L++VADH   + YR     +     N  +E+  
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-----DFQHLLNRTLEVAL 244

Query: 257 RVDDIYR--NTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDV 314
            +D  +R  N      G + +  Q + + I  +P        H+  A   P    D+   
Sbjct: 245 LLDTFFRPLNVRVALVGLEAW-TQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS--- 300

Query: 315 KMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVG 374
                               A L T   F   T+G+A   S        +C   +   V 
Sbjct: 301 --------------------AQLVTGTSFSGPTVGMAIQNS--------ICSPDFSGGVN 332

Query: 375 KKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYV 434
             +     G+ S+                 HELGH+ G +HD  G +   P        +
Sbjct: 333 MDHSTSILGVASS---------------IAHELGHSLGLDHDLPGNSCPCPGPAPAKTCI 377

Query: 435 MYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV------CGNSRVDEGEE 488
           M     S D      FSNCS++++ K +      C  ER   +      CGN  V+ GE+
Sbjct: 378 M---EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQ 434

Query: 489 CDPGIMYLNNDTCCNS-DCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSY 547
           CD G +    D CC+S  C L+ G QC+  + PCC+NCQ   +  +C+      C    +
Sbjct: 435 CDCGFLDDCVDPCCDSLTCQLRPGAQCAS-DGPCCQNCQLRPSGWQCRPT-RGDCDLPEF 492

Query: 548 CTGNSSECPPPGNAEDDTVCL-DLGKCKDGKCIPFCEREQQL 588
           C G+SS+CPP  +  D   C      C  G+C  + ++ Q L
Sbjct: 493 CPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534


>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
           preproprotein [Homo sapiens]
          Length = 839

 Score =  104 bits (259), Expect = 4e-22
 Identities = 101/402 (25%), Positives = 158/402 (39%), Gaps = 72/402 (17%)

Query: 202 REPPEELV--HRVKRRADPDPMKNTCKLLVVADH---RFYRYMGRGEESTTTNYLIELID 256
           ++PPE  +    ++RR D      T +L++VADH   + YR     +     N  +E+  
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-----DFQHLLNRTLEVAL 244

Query: 257 RVDDIYR--NTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDV 314
            +D  +R  N      G + +  Q + + I  +P        H+  A   P    D+   
Sbjct: 245 LLDTFFRPLNVRVALVGLEAW-TQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS--- 300

Query: 315 KMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVG 374
                               A L T   F   T+G+A   S        +C   +   V 
Sbjct: 301 --------------------AQLVTGTSFSGPTVGMAIQNS--------ICSPDFSGGVN 332

Query: 375 KKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYV 434
             +     G+ S+                 HELGH+ G +HD  G +   P        +
Sbjct: 333 MDHSTSILGVASS---------------IAHELGHSLGLDHDLPGNSCPCPGPAPAKTCI 377

Query: 435 MYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV------CGNSRVDEGEE 488
           M     S D      FSNCS++++ K +      C  ER   +      CGN  V+ GE+
Sbjct: 378 M---EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQ 434

Query: 489 CDPGIMYLNNDTCCNS-DCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSY 547
           CD G +    D CC+S  C L+ G QC+  + PCC+NCQ   +  +C+      C    +
Sbjct: 435 CDCGFLDDCVDPCCDSLTCQLRPGAQCAS-DGPCCQNCQLRPSGWQCRPT-RGDCDLPEF 492

Query: 548 CTGNSSECPPPGNAEDDTVCL-DLGKCKDGKCIPFCEREQQL 588
           C G+SS+CPP  +  D   C      C  G+C  + ++ Q L
Sbjct: 493 CPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534


>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
           preproprotein [Homo sapiens]
          Length = 772

 Score =  104 bits (259), Expect = 4e-22
 Identities = 101/402 (25%), Positives = 158/402 (39%), Gaps = 72/402 (17%)

Query: 202 REPPEELV--HRVKRRADPDPMKNTCKLLVVADH---RFYRYMGRGEESTTTNYLIELID 256
           ++PPE  +    ++RR D      T +L++VADH   + YR     +     N  +E+  
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-----DFQHLLNRTLEVAL 244

Query: 257 RVDDIYR--NTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDV 314
            +D  +R  N      G + +  Q + + I  +P        H+  A   P    D+   
Sbjct: 245 LLDTFFRPLNVRVALVGLEAW-TQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS--- 300

Query: 315 KMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVG 374
                               A L T   F   T+G+A   S        +C   +   V 
Sbjct: 301 --------------------AQLVTGTSFSGPTVGMAIQNS--------ICSPDFSGGVN 332

Query: 375 KKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYV 434
             +     G+ S+                 HELGH+ G +HD  G +   P        +
Sbjct: 333 MDHSTSILGVASS---------------IAHELGHSLGLDHDLPGNSCPCPGPAPAKTCI 377

Query: 435 MYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV------CGNSRVDEGEE 488
           M     S D      FSNCS++++ K +      C  ER   +      CGN  V+ GE+
Sbjct: 378 M---EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQ 434

Query: 489 CDPGIMYLNNDTCCNS-DCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSY 547
           CD G +    D CC+S  C L+ G QC+  + PCC+NCQ   +  +C+      C    +
Sbjct: 435 CDCGFLDDCVDPCCDSLTCQLRPGAQCAS-DGPCCQNCQLRPSGWQCRPT-RGDCDLPEF 492

Query: 548 CTGNSSECPPPGNAEDDTVCL-DLGKCKDGKCIPFCEREQQL 588
           C G+SS+CPP  +  D   C      C  G+C  + ++ Q L
Sbjct: 493 CPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534


>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
           preproprotein [Homo sapiens]
          Length = 814

 Score =  104 bits (259), Expect = 4e-22
 Identities = 101/402 (25%), Positives = 158/402 (39%), Gaps = 72/402 (17%)

Query: 202 REPPEELV--HRVKRRADPDPMKNTCKLLVVADH---RFYRYMGRGEESTTTNYLIELID 256
           ++PPE  +    ++RR D      T +L++VADH   + YR     +     N  +E+  
Sbjct: 190 QKPPEHPLGQRHIRRRRDVVTETKTVELVIVADHSEAQKYR-----DFQHLLNRTLEVAL 244

Query: 257 RVDDIYR--NTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDV 314
            +D  +R  N      G + +  Q + + I  +P        H+  A   P    D+   
Sbjct: 245 LLDTFFRPLNVRVALVGLEAW-TQRDLVEISPNPAVTLENFLHWRRAHLLPRLPHDS--- 300

Query: 315 KMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVG 374
                               A L T   F   T+G+A   S        +C   +   V 
Sbjct: 301 --------------------AQLVTGTSFSGPTVGMAIQNS--------ICSPDFSGGVN 332

Query: 375 KKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYV 434
             +     G+ S+                 HELGH+ G +HD  G +   P        +
Sbjct: 333 MDHSTSILGVASS---------------IAHELGHSLGLDHDLPGNSCPCPGPAPAKTCI 377

Query: 435 MYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV------CGNSRVDEGEE 488
           M     S D      FSNCS++++ K +      C  ER   +      CGN  V+ GE+
Sbjct: 378 M---EASTDFLPGLNFSNCSRRALEKALLDGMGSCLFERLPSLPPMAAFCGNMFVEPGEQ 434

Query: 489 CDPGIMYLNNDTCCNS-DCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSY 547
           CD G +    D CC+S  C L+ G QC+  + PCC+NCQ   +  +C+      C    +
Sbjct: 435 CDCGFLDDCVDPCCDSLTCQLRPGAQCAS-DGPCCQNCQLRPSGWQCRPT-RGDCDLPEF 492

Query: 548 CTGNSSECPPPGNAEDDTVCL-DLGKCKDGKCIPFCEREQQL 588
           C G+SS+CPP  +  D   C      C  G+C  + ++ Q L
Sbjct: 493 CPGDSSQCPPDVSLGDGEPCAGGQAVCMHGRCASYAQQCQSL 534


>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
           sapiens]
          Length = 819

 Score =  102 bits (254), Expect = 1e-21
 Identities = 110/451 (24%), Positives = 170/451 (37%), Gaps = 85/451 (18%)

Query: 140 INTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGL 199
           ++ + A Y IEPL     ++     ++Y+ +D+      + P  CG    D E+   K  
Sbjct: 140 LHLENASYGIEPL----QNSSHFEHIIYRMDDV-----YKEPLKCGVSNKDIEKETAKD- 189

Query: 200 VDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVD 259
            + E P  +   ++RR    P     +L +V D   Y  MGR + +     ++ L + +D
Sbjct: 190 -EEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMIL-LANYLD 247

Query: 260 DIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKD--AWDVKML 317
            +Y   +               IRI+    E+       N+     +   +   W  K L
Sbjct: 248 SMYIMLN---------------IRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFL 292

Query: 318 LEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKN 377
           + +   D A+   K              GT G+A+VG+  + SH G              
Sbjct: 293 ITRRRHDSAQLVLKKGFG----------GTAGMAFVGTVCSRSHAG-------------- 328

Query: 378 IYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYP 437
                       +G+  +   A +V  HELGHN G  HD      C      G K  +  
Sbjct: 329 --------GINVFGQITVETFASIVA-HELGHNLGMNHDDGRDCSC------GAKSCIMN 373

Query: 438 IAVSGDHENNKMFSNCSKQSIYKTIESKAQECF-------QERSNKVCGNSRVDEGEECD 490
              SG    ++ FS+CS +   K   +K   C        +  S   CGN  VD GEECD
Sbjct: 374 SGASG----SRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECD 429

Query: 491 PGI-MYLNNDTCC-NSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYC 548
            G       D CC  S C LK   +C+     CCK+C+F      C+    + C    YC
Sbjct: 430 CGTPKECELDPCCEGSTCKLKSFAECA--YGDCCKDCRFLPGGTLCR-GKTSECDVPEYC 486

Query: 549 TGNSSECPPPGNAEDDTVCL-DLGKCKDGKC 578
            G+S  C P    ++   C  +   C +G C
Sbjct: 487 NGSSQFCQPDVFIQNGYPCQNNKAYCYNGMC 517


>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
           [Homo sapiens]
          Length = 738

 Score =  101 bits (252), Expect = 2e-21
 Identities = 99/378 (26%), Positives = 157/378 (41%), Gaps = 67/378 (17%)

Query: 214 RRADPDPMKNT--CKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAG 271
           RR   + +K T   +L++VAD+R ++  G+  E      LIE+ + VD  YR  +     
Sbjct: 203 RRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR-LIEIANHVDKFYRPLN----- 256

Query: 272 FKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASK 331
                I +  + +     +    +  +     + +     W    LL + S D A+  S 
Sbjct: 257 ---IRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLD-----WRKMKLLPRKSHDNAQLVSG 308

Query: 332 VCLAHLFTYQDFDMGTLGLAYVGSP-RANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNY 390
           V          F   T+G+A + S   A+  GG+      +P+G                
Sbjct: 309 VY---------FQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLG---------------- 343

Query: 391 GKTILTKEADLVTTHELGHNFGAEHDP-DGLAECAPNEDQGGKYVMYPIAVSGDHENNKM 449
                   A +   HELGHNFG  HD  D    C    ++GG  +      S  +    +
Sbjct: 344 --------AAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMN----ASTGYPFPMV 391

Query: 450 FSNCSKQSIYKTIESKAQECF-------QERSNKVCGNSRVDEGEECDPGIMYLNNDTCC 502
           FS+CS++ +  ++E     C        +    + CGN  V+EGEECD G      + CC
Sbjct: 392 FSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451

Query: 503 N-SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNA 561
           N + CTLK    C+  +  CC++CQ + A   C+++ N +C    +CTG S  CP     
Sbjct: 452 NATTCTLKPDAVCA--HGLCCEDCQLKPAGTACRDSSN-SCDLPEFCTGASPHCPANVYL 508

Query: 562 EDDTVCLDL-GKCKDGKC 578
            D   C D+ G C +G C
Sbjct: 509 HDGHSCQDVDGYCYNGIC 526


>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
           [Homo sapiens]
          Length = 909

 Score =  101 bits (252), Expect = 2e-21
 Identities = 99/378 (26%), Positives = 157/378 (41%), Gaps = 67/378 (17%)

Query: 214 RRADPDPMKNT--CKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAG 271
           RR   + +K T   +L++VAD+R ++  G+  E      LIE+ + VD  YR  +     
Sbjct: 203 RRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR-LIEIANHVDKFYRPLN----- 256

Query: 272 FKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASK 331
                I +  + +     +    +  +     + +     W    LL + S D A+  S 
Sbjct: 257 ---IRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLD-----WRKMKLLPRKSHDNAQLVSG 308

Query: 332 VCLAHLFTYQDFDMGTLGLAYVGSP-RANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNY 390
           V          F   T+G+A + S   A+  GG+      +P+G                
Sbjct: 309 VY---------FQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLG---------------- 343

Query: 391 GKTILTKEADLVTTHELGHNFGAEHDP-DGLAECAPNEDQGGKYVMYPIAVSGDHENNKM 449
                   A +   HELGHNFG  HD  D    C    ++GG  +      S  +    +
Sbjct: 344 --------AAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMN----ASTGYPFPMV 391

Query: 450 FSNCSKQSIYKTIESKAQECF-------QERSNKVCGNSRVDEGEECDPGIMYLNNDTCC 502
           FS+CS++ +  ++E     C        +    + CGN  V+EGEECD G      + CC
Sbjct: 392 FSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451

Query: 503 N-SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNA 561
           N + CTLK    C+  +  CC++CQ + A   C+++ N +C    +CTG S  CP     
Sbjct: 452 NATTCTLKPDAVCA--HGLCCEDCQLKPAGTACRDSSN-SCDLPEFCTGASPHCPANVYL 508

Query: 562 EDDTVCLDL-GKCKDGKC 578
            D   C D+ G C +G C
Sbjct: 509 HDGHSCQDVDGYCYNGIC 526


>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 67/212 (31%), Positives = 96/212 (45%), Gaps = 31/212 (14%)

Query: 401 LVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNK---MFSNCSKQS 457
           +   H LGHN G  HD D      P      + +M        HE N     FSNCS   
Sbjct: 328 IAVAHHLGHNLGMNHDEDTCRCSQP------RCIM--------HEGNPPITKFSNCSYGD 373

Query: 458 IYK-TIESKAQECFQERSN-------KVCGNSRVDEGEECDPG-IMYLNNDTCCNSDCTL 508
            ++ T+E    +C  E  +       K CGN  V+EGEECD G + +   D CC S+CTL
Sbjct: 374 FWEYTVERT--KCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTL 431

Query: 509 KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCL 568
            +G  C+     CCK+C+F  + K C++ +N  C    +C G S +CP     ED   C 
Sbjct: 432 TDGSTCAF--GLCCKDCKFLPSGKVCRKEVNE-CDLPEWCNGTSHKCPDDFYVEDGIPCK 488

Query: 569 DLGKCKDGKCIPFCEREQQLESCACNETDNSC 600
           + G C +  C    E+ +++     N    +C
Sbjct: 489 ERGYCYEKSCHDRNEQCRRIFGAGANTASETC 520


>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 67/212 (31%), Positives = 96/212 (45%), Gaps = 31/212 (14%)

Query: 401 LVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNK---MFSNCSKQS 457
           +   H LGHN G  HD D      P      + +M        HE N     FSNCS   
Sbjct: 328 IAVAHHLGHNLGMNHDEDTCRCSQP------RCIM--------HEGNPPITKFSNCSYGD 373

Query: 458 IYK-TIESKAQECFQERSN-------KVCGNSRVDEGEECDPG-IMYLNNDTCCNSDCTL 508
            ++ T+E    +C  E  +       K CGN  V+EGEECD G + +   D CC S+CTL
Sbjct: 374 FWEYTVERT--KCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTL 431

Query: 509 KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCL 568
            +G  C+     CCK+C+F  + K C++ +N  C    +C G S +CP     ED   C 
Sbjct: 432 TDGSTCAF--GLCCKDCKFLPSGKVCRKEVNE-CDLPEWCNGTSHKCPDDFYVEDGIPCK 488

Query: 569 DLGKCKDGKCIPFCEREQQLESCACNETDNSC 600
           + G C +  C    E+ +++     N    +C
Sbjct: 489 ERGYCYEKSCHDRNEQCRRIFGAGANTASETC 520


>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 67/212 (31%), Positives = 96/212 (45%), Gaps = 31/212 (14%)

Query: 401 LVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNK---MFSNCSKQS 457
           +   H LGHN G  HD D      P      + +M        HE N     FSNCS   
Sbjct: 328 IAVAHHLGHNLGMNHDEDTCRCSQP------RCIM--------HEGNPPITKFSNCSYGD 373

Query: 458 IYK-TIESKAQECFQERSN-------KVCGNSRVDEGEECDPG-IMYLNNDTCCNSDCTL 508
            ++ T+E    +C  E  +       K CGN  V+EGEECD G + +   D CC S+CTL
Sbjct: 374 FWEYTVERT--KCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTL 431

Query: 509 KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCL 568
            +G  C+     CCK+C+F  + K C++ +N  C    +C G S +CP     ED   C 
Sbjct: 432 TDGSTCAF--GLCCKDCKFLPSGKVCRKEVNE-CDLPEWCNGTSHKCPDDFYVEDGIPCK 488

Query: 569 DLGKCKDGKCIPFCEREQQLESCACNETDNSC 600
           + G C +  C    E+ +++     N    +C
Sbjct: 489 ERGYCYEKSCHDRNEQCRRIFGAGANTASETC 520


>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
           sapiens]
          Length = 820

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 67/212 (31%), Positives = 96/212 (45%), Gaps = 31/212 (14%)

Query: 401 LVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNK---MFSNCSKQS 457
           +   H LGHN G  HD D      P      + +M        HE N     FSNCS   
Sbjct: 328 IAVAHHLGHNLGMNHDEDTCRCSQP------RCIM--------HEGNPPITKFSNCSYGD 373

Query: 458 IYK-TIESKAQECFQERSN-------KVCGNSRVDEGEECDPG-IMYLNNDTCCNSDCTL 508
            ++ T+E    +C  E  +       K CGN  V+EGEECD G + +   D CC S+CTL
Sbjct: 374 FWEYTVERT--KCLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCLSNCTL 431

Query: 509 KEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCL 568
            +G  C+     CCK+C+F  + K C++ +N  C    +C G S +CP     ED   C 
Sbjct: 432 TDGSTCAF--GLCCKDCKFLPSGKVCRKEVNE-CDLPEWCNGTSHKCPDDFYVEDGIPCK 488

Query: 569 DLGKCKDGKCIPFCEREQQLESCACNETDNSC 600
           + G C +  C    E+ +++     N    +C
Sbjct: 489 ERGYCYEKSCHDRNEQCRRIFGAGANTASETC 520


>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
           sapiens]
          Length = 832

 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 100/396 (25%), Positives = 156/396 (39%), Gaps = 79/396 (19%)

Query: 226 KLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRIL 285
           +L++V DH+ Y+   R   + T N+   +++ VD IY+              Q+    +L
Sbjct: 302 ELMIVNDHKTYK-KHRSSHAHTNNFAKSVVNLVDSIYKE-------------QLNTRVVL 347

Query: 286 KSPQEVKPGEKHYNMAKSYPNEEKDAWDVK----MLLEQFSFDIAEEASKVCLAHLFTYQ 341
            + +                  EKD  D+      +L +FS             HL +  
Sbjct: 348 VAVETWT---------------EKDQIDITTNPVQMLHEFSKYRQRIKQHADAVHLISRV 392

Query: 342 DFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADL 401
            F      L+Y G        GVC +        + + +N        YG  +   +   
Sbjct: 393 TFHYKRSSLSYFG--------GVCSRT-------RGVGVNE-------YGLPMAVAQ--- 427

Query: 402 VTTHELGHNFGAEHDPDGLA-ECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYK 460
           V +  L  N G + +P     +C   E  GG  +M    VS    +++ FS CS      
Sbjct: 428 VLSQSLAQNLGIQWEPSSRKPKCDCTESWGG-CIMEETGVS----HSRKFSKCSILEYRD 482

Query: 461 TIESKAQECFQERSNKV-----CGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCS 515
            ++     C   R  K+     CGN  V+ GEECD G        CC   C+L  G  CS
Sbjct: 483 FLQRGGGACLFNRPTKLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK-CSLSNGAHCS 541

Query: 516 DRNSPCCKN--CQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVC-LDLGK 572
           D   PCC N  C F+    +C++A+N  C    YCTG+S +CPP  + +D   C  + G+
Sbjct: 542 D--GPCCNNTSCLFQPRGYECRDAVNE-CDITEYCTGDSGQCPPNLHKQDGYACNQNQGR 598

Query: 573 CKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLS 608
           C +G+C     R+ Q +     +   S K C   L+
Sbjct: 599 CYNGEC---KTRDNQCQYIWGTKAAGSDKFCYEKLN 631


>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
           [Homo sapiens]
          Length = 906

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 76/256 (29%), Positives = 105/256 (41%), Gaps = 49/256 (19%)

Query: 336 HLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTIL 395
           HLF+   F+    G AY+G        G+C              L  G      +GKT L
Sbjct: 328 HLFSGSQFESSRSGAAYIG--------GICS------------LLKGG--GVNEFGKTDL 365

Query: 396 TKEADLVTTHELGHNFGAEHDPDGLA--ECAPNEDQGGKYVMYPIAVSGD--HENNKMFS 451
                +     L HN G   D   LA  EC   +   G        + GD  +   K F+
Sbjct: 366 MA---VTLAQSLAHNIGIISDKRKLASGECKCEDTWSG-------CIMGDTGYYLPKKFT 415

Query: 452 NCSKQSIYKTIESKAQECFQERSNKV-----CGNSRVDEGEECD---PGIMYLNNDTCCN 503
            C+ +  +  + S    C   + +K+     CGN  ++ GEECD   P    L    CC 
Sbjct: 416 QCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK 475

Query: 504 SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAED 563
             CTL +  QCSD    CCK C+F+     C+EA+N  C     C+GNSS+C P  +  D
Sbjct: 476 K-CTLTQDSQCSD--GLCCKKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMD 531

Query: 564 DTVCLDL-GKCKDGKC 578
              C  + G C  G+C
Sbjct: 532 GYSCDGVQGICFGGRC 547


>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
           [Homo sapiens]
          Length = 899

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 76/256 (29%), Positives = 105/256 (41%), Gaps = 49/256 (19%)

Query: 336 HLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTIL 395
           HLF+   F+    G AY+G        G+C              L  G      +GKT L
Sbjct: 328 HLFSGSQFESSRSGAAYIG--------GICS------------LLKGG--GVNEFGKTDL 365

Query: 396 TKEADLVTTHELGHNFGAEHDPDGLA--ECAPNEDQGGKYVMYPIAVSGD--HENNKMFS 451
                +     L HN G   D   LA  EC   +   G        + GD  +   K F+
Sbjct: 366 MA---VTLAQSLAHNIGIISDKRKLASGECKCEDTWSG-------CIMGDTGYYLPKKFT 415

Query: 452 NCSKQSIYKTIESKAQECFQERSNKV-----CGNSRVDEGEECD---PGIMYLNNDTCCN 503
            C+ +  +  + S    C   + +K+     CGN  ++ GEECD   P    L    CC 
Sbjct: 416 QCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK 475

Query: 504 SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAED 563
             CTL +  QCSD    CCK C+F+     C+EA+N  C     C+GNSS+C P  +  D
Sbjct: 476 K-CTLTQDSQCSD--GLCCKKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMD 531

Query: 564 DTVCLDL-GKCKDGKC 578
              C  + G C  G+C
Sbjct: 532 GYSCDGVQGICFGGRC 547


>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
           [Homo sapiens]
          Length = 823

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 76/256 (29%), Positives = 105/256 (41%), Gaps = 49/256 (19%)

Query: 336 HLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTIL 395
           HLF+   F+    G AY+G        G+C              L  G      +GKT L
Sbjct: 328 HLFSGSQFESSRSGAAYIG--------GICS------------LLKGG--GVNEFGKTDL 365

Query: 396 TKEADLVTTHELGHNFGAEHDPDGLA--ECAPNEDQGGKYVMYPIAVSGD--HENNKMFS 451
                +     L HN G   D   LA  EC   +   G        + GD  +   K F+
Sbjct: 366 MA---VTLAQSLAHNIGIISDKRKLASGECKCEDTWSG-------CIMGDTGYYLPKKFT 415

Query: 452 NCSKQSIYKTIESKAQECFQERSNKV-----CGNSRVDEGEECD---PGIMYLNNDTCCN 503
            C+ +  +  + S    C   + +K+     CGN  ++ GEECD   P    L    CC 
Sbjct: 416 QCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK 475

Query: 504 SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAED 563
             CTL +  QCSD    CCK C+F+     C+EA+N  C     C+GNSS+C P  +  D
Sbjct: 476 K-CTLTQDSQCSD--GLCCKKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMD 531

Query: 564 DTVCLDL-GKCKDGKC 578
              C  + G C  G+C
Sbjct: 532 GYSCDGVQGICFGGRC 547


>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
           [Homo sapiens]
          Length = 870

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 76/256 (29%), Positives = 105/256 (41%), Gaps = 49/256 (19%)

Query: 336 HLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTIL 395
           HLF+   F+    G AY+G        G+C              L  G      +GKT L
Sbjct: 328 HLFSGSQFESSRSGAAYIG--------GICS------------LLKGG--GVNEFGKTDL 365

Query: 396 TKEADLVTTHELGHNFGAEHDPDGLA--ECAPNEDQGGKYVMYPIAVSGD--HENNKMFS 451
                +     L HN G   D   LA  EC   +   G        + GD  +   K F+
Sbjct: 366 MA---VTLAQSLAHNIGIISDKRKLASGECKCEDTWSG-------CIMGDTGYYLPKKFT 415

Query: 452 NCSKQSIYKTIESKAQECFQERSNKV-----CGNSRVDEGEECD---PGIMYLNNDTCCN 503
            C+ +  +  + S    C   + +K+     CGN  ++ GEECD   P    L    CC 
Sbjct: 416 QCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK 475

Query: 504 SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAED 563
             CTL +  QCSD    CCK C+F+     C+EA+N  C     C+GNSS+C P  +  D
Sbjct: 476 K-CTLTQDSQCSD--GLCCKKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMD 531

Query: 564 DTVCLDL-GKCKDGKC 578
              C  + G C  G+C
Sbjct: 532 GYSCDGVQGICFGGRC 547


>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
           [Homo sapiens]
          Length = 859

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 76/256 (29%), Positives = 105/256 (41%), Gaps = 49/256 (19%)

Query: 336 HLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTIL 395
           HLF+   F+    G AY+G        G+C              L  G      +GKT L
Sbjct: 328 HLFSGSQFESSRSGAAYIG--------GICS------------LLKGG--GVNEFGKTDL 365

Query: 396 TKEADLVTTHELGHNFGAEHDPDGLA--ECAPNEDQGGKYVMYPIAVSGD--HENNKMFS 451
                +     L HN G   D   LA  EC   +   G        + GD  +   K F+
Sbjct: 366 MA---VTLAQSLAHNIGIISDKRKLASGECKCEDTWSG-------CIMGDTGYYLPKKFT 415

Query: 452 NCSKQSIYKTIESKAQECFQERSNKV-----CGNSRVDEGEECD---PGIMYLNNDTCCN 503
            C+ +  +  + S    C   + +K+     CGN  ++ GEECD   P    L    CC 
Sbjct: 416 QCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCK 475

Query: 504 SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAED 563
             CTL +  QCSD    CCK C+F+     C+EA+N  C     C+GNSS+C P  +  D
Sbjct: 476 K-CTLTQDSQCSD--GLCCKKCKFQPMGTVCREAVN-DCDIRETCSGNSSQCAPNIHKMD 531

Query: 564 DTVCLDL-GKCKDGKC 578
              C  + G C  G+C
Sbjct: 532 GYSCDGVQGICFGGRC 547


>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
           sapiens]
          Length = 790

 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 61/182 (33%), Positives = 75/182 (41%), Gaps = 33/182 (18%)

Query: 403 TTHELGHNFGAEHDPD-----GLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQS 457
           + HELGH  G  HD       G   C     + G                  FSNCS  S
Sbjct: 336 SAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTG------------------FSNCSYIS 377

Query: 458 IYKTIESKAQECFQERSN-----KVCGNSRVDEGEECDPGIMY-LNNDTCCNSDCTLKEG 511
            +K I S A  C           K CGN  V++ EECD G       D CC S+C L+ G
Sbjct: 378 FFKHISSGAT-CLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPG 436

Query: 512 VQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLG 571
             CS     CC +C+F  +   C++  N  C    YC GNSS CP     +D T C   G
Sbjct: 437 ANCSI--GLCCHDCRFRPSGYVCRQEGNE-CDLAEYCDGNSSSCPNDVYKQDGTPCKYEG 493

Query: 572 KC 573
           +C
Sbjct: 494 RC 495


>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
           sapiens]
          Length = 735

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 68/256 (26%), Positives = 108/256 (42%), Gaps = 40/256 (15%)

Query: 392 KTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFS 451
           +TI  +   ++    L  + G  +D     +C+     G   +M P A+       K+FS
Sbjct: 300 RTISLESLAVILAQLLSLSMGITYDDINKCQCS-----GAVCIMNPEAIH--FSGVKIFS 352

Query: 452 NCSKQSIYKTIESKAQECFQE--------RSNKVCGNSRVDEGEECDPGI---MYLNNDT 500
           NCS +     I  +  +C           +   VCGN++++ GEECD G      L  +T
Sbjct: 353 NCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGET 412

Query: 501 CCN-SDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPG 559
           CC+ + C  K G  C++   PCC+NC F + ++ C+ +    C    YC G+S+ CP   
Sbjct: 413 CCDIATCRFKAGSNCAE--GPCCENCLFMSKERMCRPSFE-ECDLPEYCNGSSASCPENH 469

Query: 560 NAE-------DDTVCLDLGKCKDG--KCIPFCEREQQLESCACNETDNSCKVCCRDLSGR 610
             +       +  +C+D G C  G  +C     +E +     C    NS      D+SG 
Sbjct: 470 YVQTGHPCGLNQWICID-GVCMSGDKQCTDTFGKEVEFGPSECYSHLNS----KTDVSGN 524

Query: 611 C----VPYVDAEQKNL 622
           C      Y   E  NL
Sbjct: 525 CGISDSGYTQCEADNL 540


>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
           sapiens]
          Length = 769

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 97/385 (25%), Positives = 144/385 (37%), Gaps = 79/385 (20%)

Query: 211 RVKRRADPDPMKNT--CKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWD 268
           R  RR  P     T   +L+V+ DH+ +  M R     T+N+   +++  D IY+     
Sbjct: 225 RQVRRGHPTVHSETKYVELIVINDHQLFEQM-RQSVVLTSNFAKSVVNLADVIYKE---- 279

Query: 269 NAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEE 328
                    Q+    +L + +    G+K           + D  +    L  +  +   E
Sbjct: 280 ---------QLNTRIVLVAMETWADGDKI--------QVQDDLLETLARLMVYRREGLPE 322

Query: 329 ASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTK 388
            S     HLF+ + F   + G AYVG   + SHGG                   G+    
Sbjct: 323 PSDA--THLFSGRTFQSTSSGAAYVGGICSLSHGG-------------------GVNEYG 361

Query: 389 NYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAP------NEDQGGKYVMYPIAVSG 442
           N G   +T    L     LG  +       G  +C         ED G      P     
Sbjct: 362 NMGAMAVTLAQTL--GQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTG---FYLP----- 411

Query: 443 DHENNKMFSNCSKQSIYKTIESKAQECFQERSNKV-----CGNSRVDEGEECDPGIMY-- 495
                + FS CS     + ++     C   +  K+     CGN  V+ GEECD G +   
Sbjct: 412 -----RKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQEC 466

Query: 496 -LNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSE 554
                 CC   CTL     CSD    CC+ C++E     C+EA+N  C     CTG+SS+
Sbjct: 467 SRAGGNCCKK-CTLTHDAMCSD--GLCCRRCKYEPRGVSCREAVN-ECDIAETCTGDSSQ 522

Query: 555 CPPPGNAEDDTVC-LDLGKCKDGKC 578
           CPP  +  D   C  + G+C  G+C
Sbjct: 523 CPPNLHKLDGYYCDHEQGRCYGGRC 547


>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
           sapiens]
          Length = 722

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 111/476 (23%), Positives = 181/476 (38%), Gaps = 89/476 (18%)

Query: 114 FFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIK 173
           ++ G+V G P+S V+           +   G  Y IEP    +  +     LVYK     
Sbjct: 110 YYHGYVEGAPESLVVFSACFGGFRGVLKISGLTYEIEP----IRHSATFEHLVYKV---- 161

Query: 174 NVSRLQSPKV-CGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVAD 232
           N +  Q P + CG      E+ + +  ++ E  E      K   D        +L+VV +
Sbjct: 162 NSNETQFPAMRCGL----TEKEVARQQLEFEEAENSALEPKSAGDWWTHAWFLELVVVVN 217

Query: 233 HRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVK 292
           H F+ Y  +   S     +  +++ VD +Y+           Y I I             
Sbjct: 218 HDFFIY-SQSNISKVQEDVFLVVNIVDSMYQQLGT-------YIILI------------- 256

Query: 293 PGEKHYNMAKSYPNEEKDAWDVKMLLEQFSF--DIAEEASKVCLAHLFTYQDFDMGTLGL 350
            G + +N    +P        ++ +L  FS    I+    +   AH+F      +  LGL
Sbjct: 257 -GIEIWNQGNVFPMTS-----IEQVLNDFSQWKQISLSQLQHDAAHMFIKNSL-ISILGL 309

Query: 351 AYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHN 410
           AYV         G+C              ++ G+ + +    ++          HELGH 
Sbjct: 310 AYVA--------GICRPP-----------IDCGVDNFQGDTWSLFAN----TVAHELGHT 346

Query: 411 FGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECF 470
            G +HD +    C    ++G   +M    V  +      F+NCS     KT  ++   C 
Sbjct: 347 LGMQHDEE-FCFCG---ERG--CIMNTFRVPAEK-----FTNCSYADFMKTTLNQGS-CL 394

Query: 471 QERSN-------KVCGNSRVDEGEECDPG-IMYLNNDTCCNSDCTLKEGVQCSDRNSPCC 522
                       K CGN  V+  E+CD G +     D CC  +CTL+ G  C+     CC
Sbjct: 395 HNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF--GLCC 452

Query: 523 KNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKC 578
           K+C+F  + + C++ +N  C    +C G S +CP     +D   C D   C   +C
Sbjct: 453 KDCKFMPSGELCRQEVNE-CDLPEWCNGTSHQCPEDRYVQDGIPCSDSAYCYQKRC 507


>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
           sapiens]
          Length = 754

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 63/208 (30%), Positives = 88/208 (42%), Gaps = 25/208 (12%)

Query: 405 HELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIES 464
           H+LGHN G +HD        P     GK VM     S        FS CS+   ++ ++ 
Sbjct: 335 HQLGHNLGMQHDE------FPCTCPSGKCVMD----SDGSIPALKFSKCSQNQYHQYLKD 384

Query: 465 KAQEC-------FQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNS-DCTLKEGVQCSD 516
               C       +     + CGN ++DEGEECD G      + CC++  C LK G  C++
Sbjct: 385 YKPTCMLNIPFPYNFHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAE 444

Query: 517 RNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDL-GKCKD 575
               CC++CQ + A   C+ A    C     CTG+S  CP      +   C +  G C  
Sbjct: 445 --GECCESCQIKKAGSICRPA-KDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFM 501

Query: 576 GKCIPFCEREQQLESCACNETDNSCKVC 603
           GKC     RE Q      +E   S  +C
Sbjct: 502 GKC---PTREDQCSELFDDEAIESHDIC 526


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,909,395
Number of Sequences: 37866
Number of extensions: 1759562
Number of successful extensions: 6680
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 6039
Number of HSP's gapped (non-prelim): 671
length of query: 824
length of database: 18,247,518
effective HSP length: 111
effective length of query: 713
effective length of database: 14,044,392
effective search space: 10013651496
effective search space used: 10013651496
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.