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Search of human proteins with 73747887
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|73747887 ADAM metallopeptidase domain 12 isoform 2
preproprotein [Homo sapiens]
(738 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprot... 1553 0.0
gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprot... 1489 0.0
gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo ... 728 0.0
gi|18252045 ADAM metallopeptidase domain 33 isoform alpha prepro... 612 e-175
gi|24041040 ADAM metallopeptidase domain 33 isoform beta preprop... 585 e-167
gi|46909600 a disintegrin and metalloproteinase domain 15 isofor... 508 e-144
gi|46909598 a disintegrin and metalloproteinase domain 15 isofor... 508 e-144
gi|46909596 a disintegrin and metalloproteinase domain 15 isofor... 508 e-144
gi|46909594 a disintegrin and metalloproteinase domain 15 isofor... 508 e-144
gi|46909592 a disintegrin and metalloproteinase domain 15 isofor... 508 e-144
gi|46909590 a disintegrin and metalloproteinase domain 15 isofor... 508 e-144
gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens] 506 e-143
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 503 e-142
gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprot... 430 e-120
gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo ... 385 e-106
gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprot... 370 e-102
gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprot... 370 e-102
gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprot... 370 e-102
gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprot... 370 e-102
gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprote... 370 e-102
gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo ... 362 e-100
gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo... 355 1e-97
gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo... 355 1e-97
gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo... 355 1e-97
gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo ... 355 1e-97
gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo s... 354 1e-97
gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprot... 351 1e-96
gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo ... 351 1e-96
gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo ... 349 5e-96
gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo s... 340 3e-93
>gi|73747887 ADAM metallopeptidase domain 12 isoform 2 preproprotein
[Homo sapiens]
Length = 738
Score = 1553 bits (4020), Expect = 0.0
Identities = 738/738 (100%), Positives = 738/738 (100%)
Query: 1 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD 60
MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
Sbjct: 1 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD 60
Query: 61 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY 120
SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY
Sbjct: 61 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY 120
Query: 121 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG 180
YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG
Sbjct: 121 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG 180
Query: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR
Sbjct: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
Query: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH
Sbjct: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
Query: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH
Sbjct: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
Query: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE
Sbjct: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
Query: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT
Sbjct: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
Query: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG
Sbjct: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
Query: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS
Sbjct: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
Query: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC 660
IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC
Sbjct: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC 660
Query: 661 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAEARQEAAESNRERGQG 720
AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAEARQEAAESNRERGQG
Sbjct: 661 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAEARQEAAESNRERGQG 720
Query: 721 QEPVGSQEHASTASLTLI 738
QEPVGSQEHASTASLTLI
Sbjct: 721 QEPVGSQEHASTASLTLI 738
>gi|73747885 ADAM metallopeptidase domain 12 isoform 1 preproprotein
[Homo sapiens]
Length = 909
Score = 1489 bits (3856), Expect = 0.0
Identities = 704/705 (99%), Positives = 705/705 (100%)
Query: 1 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD 60
MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
Sbjct: 1 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD 60
Query: 61 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY 120
SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY
Sbjct: 61 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY 120
Query: 121 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG 180
YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG
Sbjct: 121 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG 180
Query: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR
Sbjct: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
Query: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH
Sbjct: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
Query: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH
Sbjct: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
Query: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE
Sbjct: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
Query: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT
Sbjct: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
Query: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG
Sbjct: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
Query: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS
Sbjct: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
Query: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC 660
IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC
Sbjct: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC 660
Query: 661 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAE 705
AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQA+
Sbjct: 661 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAD 705
>gi|15451844 ADAM metallopeptidase domain 19 preproprotein [Homo
sapiens]
Length = 918
Score = 728 bits (1879), Expect = 0.0
Identities = 358/705 (50%), Positives = 463/705 (65%), Gaps = 31/705 (4%)
Query: 11 ARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDL--------WIPVKSFDSK 62
AR LLA A L P AR W +G + GS L W +S +
Sbjct: 8 ARLCLLAFALQPLRPRAAREPG-WTRGSEE-------GSPKLQHELIIPQWKTSESPVRE 59
Query: 63 NHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYH 122
HP +R+ E +ELI++LE+NE L A S+TETHY G + R + HC+YH
Sbjct: 60 KHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRK---LEDHCFYH 116
Query: 123 GHVRGYSDSAVSLSTCSGLRGLI-VFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGS 181
G VR S+V+LSTC G+RGLI V N SYV+EP+ + ++ ++ ++ LK G+CG
Sbjct: 117 GTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGF 176
Query: 182 HHNTPNLAAKNV-FPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
H+ P + F ++ RR KRE L + KYVEL +VAD EFQ+ +D + K +
Sbjct: 177 EHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHK 236
Query: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
LIEIAN+VDKFYR LNIRI LVG+EVW + C VS++P+++L FL WR+ KLL +K H
Sbjct: 237 LIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRR-KLLAQKYH 295
Query: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
DNAQL++G+ F GTTIG+AP+M+MC+ QSGG+ MDHS+N +G A T+AHE+GHNFGM H
Sbjct: 296 DNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTH 355
Query: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
D+ D C + GGCIM A+TG+PFP VF+ C+R++L+ L+ G G+CL N+P+ R
Sbjct: 356 DSAD---CCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRM 412
Query: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
+GG++CGN ++E+GEECDCGE EEC N CCNA+ CTL+P A CAHG CC C+L GT
Sbjct: 413 LYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGT 472
Query: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
CR+ + CDLPEFCTG SPHCP N Y DG C+ YCYNG+C T+++QC LWGPG
Sbjct: 473 LCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPG 532
Query: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
A+PAP +CFE+VN AGD +GNCGK KC MRDAKCGKIQCQ +RP + +NAV
Sbjct: 533 ARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP-LESNAVP 591
Query: 601 IETNIPLQQGGRILCRGTHVYLG----DDMPDPGLVLAGTKCADGKICLNRQCQNISVFG 656
I+T I + G +I CRGTHVY G DM DPGLV+ GTKC IC QC+N S F
Sbjct: 592 IDTTI-IMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFE 650
Query: 657 VHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPI 701
C +C+G GVCNN +NCHC WAPPFC+ G GGS DSGP+
Sbjct: 651 TEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPM 695
>gi|18252045 ADAM metallopeptidase domain 33 isoform alpha
preproprotein [Homo sapiens]
Length = 813
Score = 612 bits (1578), Expect = e-175
Identities = 319/699 (45%), Positives = 421/699 (60%), Gaps = 21/699 (3%)
Query: 14 LLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQ 73
LLL L LL P GV L V V G W V + + P++ + L+
Sbjct: 13 LLLLLLLLLLWPVPGAGV-LQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALE 71
Query: 74 RESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAV 133
E +EL++ LE+N L+A + ETHY DG V LA N+T HC+Y G VRG+ DS V
Sbjct: 72 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT---DHCHYQGRVRGFPDSWV 128
Query: 134 SLSTCSGLRGLIVFE-NESYVLEPMKSATNR----YKLFPAKKLKSVRGSCGSHHNTPNL 188
L TCSG+ GLI N SY L P ++ +++F ++L + +G+CG H + N
Sbjct: 129 VLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG-HRDPGNK 187
Query: 189 AAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
A P Q+ RR R T KY+EL IVAD+ F + ++L KQRL+E+AN+V
Sbjct: 188 AGMTSLPGGPQSRGRREARRT---RKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
Query: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
D+ R L+I++ L G+EVW + D+ V+QD +L FL WR+ L ++ HD+AQL++G
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRR-GLWAQRPHDSAQLLTG 303
Query: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
FQG T+G+AP+ MC A+ SGG+ DHS+ P+GAA T+AHE+GH+ G++HD GC
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP--DGCC 361
Query: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCG 428
+ A E GGC+M A+TG+PFP VFS+CSR+ L KG G CL N P+ CG
Sbjct: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421
Query: 429 NRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNS 488
N FVE GEECDCG +EC + CC A C+L+P A CAHG CC C LKPAG CR +
Sbjct: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
Query: 489 CDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGIC 548
CDLPEFCTG S HCP +VYL DG C GYC++G C T EQQC LWGPG+ PAP C
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
Query: 549 FERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQ 608
F+ VNSAGD +GNCG+ S+ F C RDA CGK+QCQGG ++ + V +++ + L
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG-KPSLLAPHMVPVDSTVHL- 599
Query: 609 QGGRILCRGTHVYLGD--DMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHG 666
G + CRG D+ GLV GT+C +C +R+C+ + + C CH
Sbjct: 600 DGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHS 659
Query: 667 RGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAE 705
GVCN+ NCHC WAPPFCDK GFGGS DSGP+ QAE
Sbjct: 660 HGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV-QAE 697
>gi|24041040 ADAM metallopeptidase domain 33 isoform beta
preproprotein [Homo sapiens]
Length = 787
Score = 585 bits (1507), Expect = e-167
Identities = 314/697 (45%), Positives = 410/697 (58%), Gaps = 43/697 (6%)
Query: 14 LLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQ 73
LLL L LL P GV L V V G W V + + P++ + L+
Sbjct: 13 LLLLLLLLLLWPVPGAGV-LQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALE 71
Query: 74 RESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAV 133
E +EL++ LE+N L+A + ETHY DG V LA N+T HC+Y G VRG+ DS V
Sbjct: 72 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT---DHCHYQGRVRGFPDSWV 128
Query: 134 SLSTCSGLRGLIVFE-NESYVLEPMKSATNR----YKLFPAKKLKSVRGSCGSHHNTPNL 188
L TCSG+ GLI N SY L P ++ +++F ++L + +G+CG H + N
Sbjct: 129 VLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG-HRDPGNK 187
Query: 189 AAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
A P Q+ RR R T KY+EL IVAD+ F + ++L KQRL+E+AN+V
Sbjct: 188 AGMTSLPGGPQSRGRREARRT---RKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYV 244
Query: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
D+ R L+I++ L G+EVW + D+ V+QD +L FL WR+ L ++ HD+AQL++G
Sbjct: 245 DQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRR-GLWAQRPHDSAQLLTG 303
Query: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
FQG T+G+AP+ MC A+ SGG+ DHS+ P+GAA T+AHE+GH+ G++HD GC
Sbjct: 304 RAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDP--DGCC 361
Query: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCG 428
+ A E GGC+M A+TG+PFP VFS+CSR+ L KG G CL N P+ CG
Sbjct: 362 VEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCG 421
Query: 429 NRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNS 488
N FVE GEECDCG +EC + CC A C+L+P A CAHG CC C LKPAG CR +
Sbjct: 422 NGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGD 481
Query: 489 CDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGIC 548
CDLPEFCTG S HCP +VYL DG C GYC++G C T EQQC LWGPG+ PAP C
Sbjct: 482 CDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEAC 541
Query: 549 FERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQ 608
F+ VNSAGD +GNCG+ S+ F C RDA CGK+QCQGG ++ + V +++ + L
Sbjct: 542 FQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGG-KPSLLAPHMVPVDSTVHL- 599
Query: 609 QGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRG 668
G + CRG +P L L G G+ E QC R
Sbjct: 600 DGQEVTCRGALA-----LPSAQLDLLG-------------------LGLVEPGTQCGPRM 635
Query: 669 VCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAE 705
VCN+ NCHC WAPPFCDK GFGGS DSGP+ QAE
Sbjct: 636 VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPV-QAE 671
>gi|46909600 a disintegrin and metalloproteinase domain 15 isoform 6
preproprotein [Homo sapiens]
Length = 863
Score = 508 bits (1309), Expect = e-144
Identities = 269/654 (41%), Positives = 378/654 (57%), Gaps = 18/654 (2%)
Query: 41 EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
E + V DL I +K + PE L I+L+ + I+ L +N L+ T Y
Sbjct: 42 EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
DGT V ++ +T L +C Y G VRGY+ S VS+ TCSGLRGL+V E SY LE
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
+ + + G +C K PP +RH +R+ + TK
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
VELVIVAD+ E Q+ +D + + R +E+A +D F+RPLN+R+ LVG+E W D +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
S +P +L FL WR+ LLPR HD+AQLV+G F G T+GMA S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
DHS + LG A ++AHELGH+ G++HD C C CIM AST + + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
SR+ LE +L GMG CLF LP + CGN FVE GE+CDCG ++C++ CC++
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
TC L+P A CA G CC++CQL+P+G CR + CDLPEFC G S CP +V L DG
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
C C +G C ++ QQC +LWGPGA+PA +C + N+ G+ +G+CG+ S+ C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
RDA CG++QCQ G ++P++G+ + I + G + C H+ LG D+ P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687
GT C G +C++ +CQ + + G EC +CHG GVC++ ++C+CE WAPP C
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909598 a disintegrin and metalloproteinase domain 15 isoform 5
preproprotein [Homo sapiens]
Length = 862
Score = 508 bits (1309), Expect = e-144
Identities = 269/654 (41%), Positives = 378/654 (57%), Gaps = 18/654 (2%)
Query: 41 EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
E + V DL I +K + PE L I+L+ + I+ L +N L+ T Y
Sbjct: 42 EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
DGT V ++ +T L +C Y G VRGY+ S VS+ TCSGLRGL+V E SY LE
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
+ + + G +C K PP +RH +R+ + TK
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
VELVIVAD+ E Q+ +D + + R +E+A +D F+RPLN+R+ LVG+E W D +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
S +P +L FL WR+ LLPR HD+AQLV+G F G T+GMA S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
DHS + LG A ++AHELGH+ G++HD C C CIM AST + + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
SR+ LE +L GMG CLF LP + CGN FVE GE+CDCG ++C++ CC++
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
TC L+P A CA G CC++CQL+P+G CR + CDLPEFC G S CP +V L DG
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
C C +G C ++ QQC +LWGPGA+PA +C + N+ G+ +G+CG+ S+ C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
RDA CG++QCQ G ++P++G+ + I + G + C H+ LG D+ P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687
GT C G +C++ +CQ + + G EC +CHG GVC++ ++C+CE WAPP C
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909596 a disintegrin and metalloproteinase domain 15 isoform 4
preproprotein [Homo sapiens]
Length = 838
Score = 508 bits (1309), Expect = e-144
Identities = 269/654 (41%), Positives = 378/654 (57%), Gaps = 18/654 (2%)
Query: 41 EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
E + V DL I +K + PE L I+L+ + I+ L +N L+ T Y
Sbjct: 42 EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
DGT V ++ +T L +C Y G VRGY+ S VS+ TCSGLRGL+V E SY LE
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
+ + + G +C K PP +RH +R+ + TK
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
VELVIVAD+ E Q+ +D + + R +E+A +D F+RPLN+R+ LVG+E W D +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
S +P +L FL WR+ LLPR HD+AQLV+G F G T+GMA S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
DHS + LG A ++AHELGH+ G++HD C C CIM AST + + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
SR+ LE +L GMG CLF LP + CGN FVE GE+CDCG ++C++ CC++
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
TC L+P A CA G CC++CQL+P+G CR + CDLPEFC G S CP +V L DG
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
C C +G C ++ QQC +LWGPGA+PA +C + N+ G+ +G+CG+ S+ C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
RDA CG++QCQ G ++P++G+ + I + G + C H+ LG D+ P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687
GT C G +C++ +CQ + + G EC +CHG GVC++ ++C+CE WAPP C
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909594 a disintegrin and metalloproteinase domain 15 isoform 3
preproprotein [Homo sapiens]
Length = 839
Score = 508 bits (1309), Expect = e-144
Identities = 269/654 (41%), Positives = 378/654 (57%), Gaps = 18/654 (2%)
Query: 41 EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
E + V DL I +K + PE L I+L+ + I+ L +N L+ T Y
Sbjct: 42 EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
DGT V ++ +T L +C Y G VRGY+ S VS+ TCSGLRGL+V E SY LE
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
+ + + G +C K PP +RH +R+ + TK
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
VELVIVAD+ E Q+ +D + + R +E+A +D F+RPLN+R+ LVG+E W D +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
S +P +L FL WR+ LLPR HD+AQLV+G F G T+GMA S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
DHS + LG A ++AHELGH+ G++HD C C CIM AST + + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
SR+ LE +L GMG CLF LP + CGN FVE GE+CDCG ++C++ CC++
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
TC L+P A CA G CC++CQL+P+G CR + CDLPEFC G S CP +V L DG
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
C C +G C ++ QQC +LWGPGA+PA +C + N+ G+ +G+CG+ S+ C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
RDA CG++QCQ G ++P++G+ + I + G + C H+ LG D+ P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687
GT C G +C++ +CQ + + G EC +CHG GVC++ ++C+CE WAPP C
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909592 a disintegrin and metalloproteinase domain 15 isoform 1
preproprotein [Homo sapiens]
Length = 772
Score = 508 bits (1309), Expect = e-144
Identities = 269/654 (41%), Positives = 378/654 (57%), Gaps = 18/654 (2%)
Query: 41 EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
E + V DL I +K + PE L I+L+ + I+ L +N L+ T Y
Sbjct: 42 EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
DGT V ++ +T L +C Y G VRGY+ S VS+ TCSGLRGL+V E SY LE
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
+ + + G +C K PP +RH +R+ + TK
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
VELVIVAD+ E Q+ +D + + R +E+A +D F+RPLN+R+ LVG+E W D +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
S +P +L FL WR+ LLPR HD+AQLV+G F G T+GMA S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
DHS + LG A ++AHELGH+ G++HD C C CIM AST + + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
SR+ LE +L GMG CLF LP + CGN FVE GE+CDCG ++C++ CC++
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
TC L+P A CA G CC++CQL+P+G CR + CDLPEFC G S CP +V L DG
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
C C +G C ++ QQC +LWGPGA+PA +C + N+ G+ +G+CG+ S+ C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
RDA CG++QCQ G ++P++G+ + I + G + C H+ LG D+ P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687
GT C G +C++ +CQ + + G EC +CHG GVC++ ++C+CE WAPP C
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|46909590 a disintegrin and metalloproteinase domain 15 isoform 2
preproprotein [Homo sapiens]
Length = 814
Score = 508 bits (1309), Expect = e-144
Identities = 269/654 (41%), Positives = 378/654 (57%), Gaps = 18/654 (2%)
Query: 41 EVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYL 100
E + V DL I +K + PE L I+L+ + I+ L +N L+ T Y
Sbjct: 42 EPLEPQVLQDDLPISLKKVLQTSLPEPLRIKLELDGDSHILELLQNRELVPGRPTLVWYQ 101
Query: 101 QDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENE-SYVLEPMKS 159
DGT V ++ +T L +C Y G VRGY+ S VS+ TCSGLRGL+V E SY LE
Sbjct: 102 PDGTRV-VSEGHT--LENCCYQGRVRGYAGSWVSICTCSGLRGLVVLTPERSYTLEQGPG 158
Query: 160 ATNRYKLFPAKKLKSVRG-SCGSHHNTPNLAAKNVFPPPSQTWARRH---KRETLKATKY 215
+ + + G +C K PP +RH +R+ + TK
Sbjct: 159 DLQGPPIISRIQDLHLPGHTCALSWRESVHTQK----PPEHPLGQRHIRRRRDVVTETKT 214
Query: 216 VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSV 275
VELVIVAD+ E Q+ +D + + R +E+A +D F+RPLN+R+ LVG+E W D +
Sbjct: 215 VELVIVADHSEAQKY-RDFQHLLNRTLEVALLLDTFFRPLNVRVALVGLEAWTQRDLVEI 273
Query: 276 SQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVM 335
S +P +L FL WR+ LLPR HD+AQLV+G F G T+GMA S+C+ D SGG+ M
Sbjct: 274 SPNPAVTLENFLHWRRAHLLPRLPHDSAQLVTGTSFSGPTVGMAIQNSICSPDFSGGVNM 333
Query: 336 DHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSC 395
DHS + LG A ++AHELGH+ G++HD C C CIM AST + + FS+C
Sbjct: 334 DHSTSILGVASSIAHELGHSLGLDHDLPGNSCPCPGPAPAKTCIMEASTDFLPGLNFSNC 393
Query: 396 SRKDLETSLEKGMGVCLF-NLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNAT 454
SR+ LE +L GMG CLF LP + CGN FVE GE+CDCG ++C++ CC++
Sbjct: 394 SRRALEKALLDGMGSCLFERLPSLPPM--AAFCGNMFVEPGEQCDCGFLDDCVDPCCDSL 451
Query: 455 TCTLKPDAVCA-HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHS 513
TC L+P A CA G CC++CQL+P+G CR + CDLPEFC G S CP +V L DG
Sbjct: 452 TCQLRPGAQCASDGPCCQNCQLRPSGWQCRPTRGDCDLPEFCPGDSSQCPPDVSLGDGEP 511
Query: 514 CQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKC 573
C C +G C ++ QQC +LWGPGA+PA +C + N+ G+ +G+CG+ S+ C
Sbjct: 512 CAGGQAVCMHGRCASYAQQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRNPSGSYVSC 571
Query: 574 EMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVL 633
RDA CG++QCQ G ++P++G+ + I + G + C H+ LG D+ P L L
Sbjct: 572 TPRDAICGQLQCQTGRTQPLLGSIRDLLWETIDV-NGTELNCSWVHLDLGSDVAQPLLTL 630
Query: 634 AGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFC 687
GT C G +C++ +CQ + + G EC +CHG GVC++ ++C+CE WAPP C
Sbjct: 631 PGTACGPGLVCIDHRCQRVDLLGAQECRSKCHGHGVCDSNRHCYCEEGWAPPDC 684
>gi|69354859 ADAM metallopeptidase domain 8 precursor [Homo sapiens]
Length = 856
Score = 506 bits (1302), Expect = e-143
Identities = 264/637 (41%), Positives = 355/637 (55%), Gaps = 58/637 (9%)
Query: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
HPE ++ L ++L +N L+ S +TET+ +G++V+ HC+Y G
Sbjct: 53 HPERVSYVLGATGHNFTLHLRKNRDLLGSGYTETYTAANGSEVTEQPRGQ---DHCFYQG 109
Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATN--RYKLFPAKKLKSVRGSCGS 181
HV GY DSA SLSTC+GLRG ++ +++EP+ R+ ++ A+ L G+CG
Sbjct: 110 HVEGYPDSAASLSTCAGLRGFFQVGSDLHLIEPLDEGGEGGRHAVYQAEHLLQTAGTCGV 169
Query: 182 HHNT------PNLAAKNVFPP-PSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
++ P AA VF P P + R T+YVEL +V DN EFQ G +
Sbjct: 170 SDDSLGSLLGPRTAA--VFRPRPGDSLPSRE-------TRYVELYVVVDNAEFQMLGSEA 220
Query: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294
V+ R++E+ NHVDK Y+ LN R+VLVG+E+WN D+ VS DP +L L W+ +
Sbjct: 221 A-VRHRVLEVVNHVDKLYQKLNFRVVLVGLEIWNSQDRFHVSPDPSVTLENLLTWQARQR 279
Query: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354
R HDN QL++GV F GTT+G A + +MC+ SG + DHS NP+G A T+AHE+GH
Sbjct: 280 TRRHLHDNVQLITGVDFTGTTVGFARVSAMCS-HSSGAVNQDHSKNPVGVACTMAHEMGH 338
Query: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
N GM+HD +GC CQ E G CIM S G FP +FS CS+ LE+ LE+ VCL N
Sbjct: 339 NLGMDHDENVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCLAN 398
Query: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474
P++ GG CGN FVE GE+CDCG PE+C NRCCN+TTC L A CAHG CC++C+
Sbjct: 399 APDLSHLVGGPVCGNLFVERGEQCDCGPPEDCRNRCCNSTTCQLAEGAQCAHGTCCQECK 458
Query: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534
+KPAG CR + CDL EFC G P CP + + +G C GYCYNG C T QQC
Sbjct: 459 VKPAGELCRPKKDMCDLEEFCDGRHPECPEDAFQENGTPCS--GGYCYNGACPTLAQQCQ 516
Query: 535 TLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVI 594
WGPG + A CF + D C K+S + +M CG +QC+GG
Sbjct: 517 AFWGPGGQAAEESCF-----SYDILPGC----KASRYRADM----CGVLQCKGGQ----- 558
Query: 595 GTNAVSIETNIPLQQGGRILC--RGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNI 652
Q GR +C H +D V GT+C K+C +CQ++
Sbjct: 559 -------------QPLGRAICIVDVCHALTTEDGTAYEPVPEGTRCGPEKVCWKGRCQDL 605
Query: 653 SVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDK 689
V+ C+ QCH GVCN+++ CHC A WAPP C K
Sbjct: 606 HVYRSSNCSAQCHNHGVCNHKQECHCHAGWAPPHCAK 642
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 503 bits (1295), Expect = e-142
Identities = 272/636 (42%), Positives = 380/636 (59%), Gaps = 26/636 (4%)
Query: 72 LQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDS 131
+Q E KE II+LERN+ L+ F Y ++GT L ++ I HC+Y G+V G +S
Sbjct: 70 IQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGT---LITDHPNIQNHCHYRGYVEGVHNS 126
Query: 132 AVSLSTCSGLRGLIVFENESYVLEPMKSATN-RYKLFPAKKLKSVRGSCG-SHHNTPNLA 189
+++LS C GLRGL+ EN SY +EP++++++ + ++ + CG S+ +
Sbjct: 127 SIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKET 186
Query: 190 AKNVFP-PPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHV 248
AK+ PPS T R +R L T+YVEL IV D + G++ V++ +I +AN++
Sbjct: 187 AKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYL 246
Query: 249 DKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSG 308
D Y LNIRIVLVG+E+W + + ++ L F+ WR+ L+ R+ HD+AQLV
Sbjct: 247 DSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDSAQLVLK 306
Query: 309 VYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
F GT GMA + ++C+ +GGI + A +AHELGHN GMNHD R CS
Sbjct: 307 KGFGGTA-GMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDD-GRDCS 364
Query: 369 CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLET-SLEKGMGVCLFNLPEVRESFGGQKC 427
C CIMN+ G FSSCS +D E +L KG G CL N+P+ E++ C
Sbjct: 365 CGAK----SCIMNS--GASGSRNFSSCSAEDFEKLTLNKG-GNCLLNIPKPDEAYSAPSC 417
Query: 428 GNRFVEEGEECDCGEPEEC-MNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS 486
GN+ V+ GEECDCG P+EC ++ CC +TC LK A CA+G CC+DC+ P GT CR +
Sbjct: 418 GNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKT 477
Query: 487 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG 546
+ CD+PE+C G+S C +V++ +G+ CQ+ YCYNG+CQ ++ QC ++G AK AP
Sbjct: 478 SECDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPK 537
Query: 547 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP 606
CF VNS GD +GNCG S + + KC +A CGK+QC+ PV G I+T
Sbjct: 538 DCFIEVNSKGDRFGNCG-FSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTP-- 594
Query: 607 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ--C 664
+G + C G LG D+PDPG+V GTKC GKIC N QC + SV ++C +Q C
Sbjct: 595 -SRGTK--CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLN-YDCDVQKKC 650
Query: 665 HGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
HG GVCN+ KNCHCE WAPP C+ G+GGS DSGP
Sbjct: 651 HGHGVCNSNKNCHCENGWAPPNCETKGYGGSVDSGP 686
>gi|98985828 ADAM metallopeptidase domain 28 isoform 1 preproprotein
[Homo sapiens]
Length = 775
Score = 430 bits (1105), Expect = e-120
Identities = 233/637 (36%), Positives = 339/637 (53%), Gaps = 52/637 (8%)
Query: 68 LNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRG 127
L ++ K ++ L++N+ L+A +TET+Y G +++ + I+ CYY GH+
Sbjct: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQ---IMDDCYYQGHILN 113
Query: 128 YSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-------YKLFPAKKLKSVRGSCG 180
S S+STC GLRG ++ Y +EP+ S +R +K P +K + +CG
Sbjct: 114 EKVSDASISTCRGLRGYFSQGDQRYFIEPL-SPIHRDGQEHALFKYNPDEK--NYDSTCG 170
Query: 181 ------SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
+H N+A P+ + R+ + KY+E +V DN EF+R ++
Sbjct: 171 MDGVLWAHDLQQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQ 224
Query: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294
+++++R+ E+AN+V+ Y+ LN + LVG+E+W D DK ++ + +L F WR L
Sbjct: 225 DEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVL 284
Query: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354
RK HD AQL++ GTT+G+A + +MC+ S G+V DHSDN L A T+AHE+GH
Sbjct: 285 SRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGH 343
Query: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
NFGM HD D C C + C+M+ + + P FSSCSR + E + CLFN
Sbjct: 344 NFGMFHD--DYSCKCPSTI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
Query: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474
P + CGN+ VE GE+CDCG EEC N CC+A TC +K CA G CCE CQ
Sbjct: 398 APLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQ 457
Query: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534
K AG CR + + CDLPE C G S +CP + + +G C G+C G C T ++QC
Sbjct: 458 FKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCT 517
Query: 535 TLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVI 594
LWGPG + A C+ R N G YG C +V + C+ D CGK+ CQGG+
Sbjct: 518 ELWGPGTEVADKSCYNR-NEGGSKYGYCRRVD-DTLIPCKANDTMCGKLFCQGGSD---- 571
Query: 595 GTNAVSIETNIPLQQGGRILCRGTHVYLG--DDMPDPGLVLAGTKCADGKICLNRQCQNI 652
N+P + GRI+ T D + G+V GTKC D K+C+N +C +I
Sbjct: 572 ---------NLPWK--GRIVTFLTCKTFDPEDTSQEIGMVANGTKCGDNKVCINAECVDI 620
Query: 653 -SVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCD 688
+ C+ +C G VC++ C CE W PP CD
Sbjct: 621 EKAYKSTNCSSKCKGHAVCDHELQCQCEEGWIPPDCD 657
>gi|114326453 a disintegrin and metalloproteinase domain 7 [Homo
sapiens]
Length = 754
Score = 385 bits (988), Expect = e-106
Identities = 216/630 (34%), Positives = 331/630 (52%), Gaps = 22/630 (3%)
Query: 62 KNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYY 121
K + E L ++ K L+++L R+ + S+++ET Y G + + I+ HC+Y
Sbjct: 53 KTYEEELLYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFT---RHPQIMDHCFY 109
Query: 122 HGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMK-SATNRYKLFPAKKLKSVRGSCG 180
G + DSA S+STC+GLRG ++ Y++EP+K S + +F ++R G
Sbjct: 110 QGSIVHEYDSAASISTCNGLRGFFRINDQRYLIEPVKYSDEGEHLVFKY----NLRVPYG 165
Query: 181 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR 240
++++ L P K + + KYVEL IVAD+ ++R G K++ R
Sbjct: 166 ANYSCTELNFTRKTVPGDNESEEDSKIKGIHDEKYVELFIVADDTVYRRNGHPHNKLRNR 225
Query: 241 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH 300
+ + N V+ Y+ LNI + LVG+E+W DK + + T+L F W++ L RK
Sbjct: 226 IWGMVNFVNMIYKTLNIHVTLVGIEIWTHEDKIELYSNIETTLLRFSFWQEKILKTRKDF 285
Query: 301 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH 360
D+ L+SG + G++ MC S I+ D + A +AH+LGHN GM H
Sbjct: 286 DHVVLLSGKWLYSHVQGISYPGGMCLPYYSTSIIKDLLPDTNIIANRMAHQLGHNLGMQH 345
Query: 361 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE 420
D C+C G C+M++ P + FS CS+ L+ C+ N+P
Sbjct: 346 DEFP--CTCP----SGKCVMDSDGSIP-ALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYN 398
Query: 421 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT 480
Q CGN+ ++EGEECDCG +EC N CC+A TC LKP CA G CCE CQ+K AG+
Sbjct: 399 FHDFQFCGNKKLDEGEECDCGPAQECTNPCCDAHTCVLKPGFTCAEGECCESCQIKKAGS 458
Query: 481 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG 540
CR + + CD PE CTG SP CP + + +G C++ +GYC+ G C T E QC L+
Sbjct: 459 ICRPAKDECDFPEMCTGHSPACPKDQFRVNGFPCKNSEGYCFMGKCPTREDQCSELFDDE 518
Query: 541 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS 600
A + IC+ ++N+ G+ +G C K ++ F CE +D +CGKI C GG ++G + +
Sbjct: 519 AIESHDICY-KMNTKGNKFGYC-KNKENRFLPCEEKDVRCGKIYCTGGELSSLLGEDK-T 575
Query: 601 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNI-SVFGVHE 659
P Q+ + C+ ++L D D GLV +GTKC +G +C N +C N+ V+
Sbjct: 576 YHLKDP-QKNATVKCK--TIFLYHDSTDIGLVASGTKCGEGMVCNNGECLNMEKVYISTN 632
Query: 660 CAMQCHGRGVCNNRKNCHCEAHWAPPFCDK 689
C QC+ V + CHCE AP C++
Sbjct: 633 CPSQCNENPVDGHGLQCHCEEGQAPVACEE 662
>gi|11497047 ADAM metallopeptidase domain 22 isoform 1 preproprotein
[Homo sapiens]
Length = 906
Score = 370 bits (951), Expect = e-102
Identities = 213/650 (32%), Positives = 320/650 (49%), Gaps = 43/650 (6%)
Query: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
H + + ++ I+++ N L++S + E H G V + HCYY G
Sbjct: 85 HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
H+RG DS V+LSTC GL G+ N +Y++EP ++ T + + ++ ++ +
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
S N+ P S+ RR+ R + TKY+EL+IV D+ F++ +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
+ N D Y+ L RIVLV +E W +K ++S++P +L EF+ +R+
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
+ ++ D L SG F+ + G A I +C+ + GG+ N G AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
L HN G+ D C+ GCIM TGY P F+ C+ ++ L G
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
G CLFN P + +CGN F+E GEECDCG P EC+ CC CTL D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
GLCC+ C+ +P GT CR++ N CD+ E C+G S C N++ DG+SC V G C+ G
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
C+T ++QC +WG + C+E++N G GNCGK K ++ +C RD CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
+ P +G I + + +QQG + C G HV L +D+ D G V GT C +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKF 690
+C ++ F C C G GVC+N C C HW C+ +
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY 714
>gi|21536386 ADAM metallopeptidase domain 22 isoform 2 preproprotein
[Homo sapiens]
Length = 899
Score = 370 bits (951), Expect = e-102
Identities = 213/650 (32%), Positives = 320/650 (49%), Gaps = 43/650 (6%)
Query: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
H + + ++ I+++ N L++S + E H G V + HCYY G
Sbjct: 85 HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
H+RG DS V+LSTC GL G+ N +Y++EP ++ T + + ++ ++ +
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
S N+ P S+ RR+ R + TKY+EL+IV D+ F++ +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
+ N D Y+ L RIVLV +E W +K ++S++P +L EF+ +R+
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
+ ++ D L SG F+ + G A I +C+ + GG+ N G AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
L HN G+ D C+ GCIM TGY P F+ C+ ++ L G
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
G CLFN P + +CGN F+E GEECDCG P EC+ CC CTL D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
GLCC+ C+ +P GT CR++ N CD+ E C+G S C N++ DG+SC V G C+ G
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
C+T ++QC +WG + C+E++N G GNCGK K ++ +C RD CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
+ P +G I + + +QQG + C G HV L +D+ D G V GT C +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKF 690
+C ++ F C C G GVC+N C C HW C+ +
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY 714
>gi|11497043 ADAM metallopeptidase domain 22 isoform 5 preproprotein
[Homo sapiens]
Length = 823
Score = 370 bits (951), Expect = e-102
Identities = 213/650 (32%), Positives = 320/650 (49%), Gaps = 43/650 (6%)
Query: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
H + + ++ I+++ N L++S + E H G V + HCYY G
Sbjct: 85 HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
H+RG DS V+LSTC GL G+ N +Y++EP ++ T + + ++ ++ +
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
S N+ P S+ RR+ R + TKY+EL+IV D+ F++ +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
+ N D Y+ L RIVLV +E W +K ++S++P +L EF+ +R+
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
+ ++ D L SG F+ + G A I +C+ + GG+ N G AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
L HN G+ D C+ GCIM TGY P F+ C+ ++ L G
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
G CLFN P + +CGN F+E GEECDCG P EC+ CC CTL D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
GLCC+ C+ +P GT CR++ N CD+ E C+G S C N++ DG+SC V G C+ G
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
C+T ++QC +WG + C+E++N G GNCGK K ++ +C RD CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
+ P +G I + + +QQG + C G HV L +D+ D G V GT C +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKF 690
+C ++ F C C G GVC+N C C HW C+ +
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY 714
>gi|21536383 ADAM metallopeptidase domain 22 isoform 3 preproprotein
[Homo sapiens]
Length = 870
Score = 370 bits (951), Expect = e-102
Identities = 213/650 (32%), Positives = 320/650 (49%), Gaps = 43/650 (6%)
Query: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
H + + ++ I+++ N L++S + E H G V + HCYY G
Sbjct: 85 HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
H+RG DS V+LSTC GL G+ N +Y++EP ++ T + + ++ ++ +
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
S N+ P S+ RR+ R + TKY+EL+IV D+ F++ +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
+ N D Y+ L RIVLV +E W +K ++S++P +L EF+ +R+
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
+ ++ D L SG F+ + G A I +C+ + GG+ N G AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
L HN G+ D C+ GCIM TGY P F+ C+ ++ L G
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
G CLFN P + +CGN F+E GEECDCG P EC+ CC CTL D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
GLCC+ C+ +P GT CR++ N CD+ E C+G S C N++ DG+SC V G C+ G
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
C+T ++QC +WG + C+E++N G GNCGK K ++ +C RD CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
+ P +G I + + +QQG + C G HV L +D+ D G V GT C +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKF 690
+C ++ F C C G GVC+N C C HW C+ +
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY 714
>gi|4757722 ADAM metallopeptidase domain 22 isoform 4 preproprotein
[Homo sapiens]
Length = 859
Score = 370 bits (951), Expect = e-102
Identities = 213/650 (32%), Positives = 320/650 (49%), Gaps = 43/650 (6%)
Query: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
H + + ++ I+++ N L++S + E H G V + HCYY G
Sbjct: 85 HVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGE-----HCYYQG 139
Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-----YKLFPAKKLKSVRGS 178
H+RG DS V+LSTC GL G+ N +Y++EP ++ T + + ++ ++ +
Sbjct: 140 HIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDD 199
Query: 179 CGSHHNTPNLAAKNVF----PPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
S N+ P S+ RR+ R + TKY+EL+IV D+ F++ +
Sbjct: 200 LPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSV 259
Query: 235 EKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMK 293
+ N D Y+ L RIVLV +E W +K ++S++P +L EF+ +R+
Sbjct: 260 VHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDF 319
Query: 294 LLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGA----AVTLA 349
+ ++ D L SG F+ + G A I +C+ + GG+ N G AVTLA
Sbjct: 320 I--KEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGV------NEFGKTDLMAVTLA 371
Query: 350 HELGHNFGMNHDTLDRGCS-CQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGM 408
L HN G+ D C+ GCIM TGY P F+ C+ ++ L G
Sbjct: 372 QSLAHNIGIISDKRKLASGECKCEDTWSGCIMG-DTGYYLPKKFTQCNIEEYHDFLNSGG 430
Query: 409 GVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECM---NRCCNATTCTLKPDAVCA 465
G CLFN P + +CGN F+E GEECDCG P EC+ CC CTL D+ C+
Sbjct: 431 GACLFNKPS--KLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKK--CTLTQDSQCS 486
Query: 466 HGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGI 525
GLCC+ C+ +P GT CR++ N CD+ E C+G S C N++ DG+SC V G C+ G
Sbjct: 487 DGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGR 546
Query: 526 CQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQC 585
C+T ++QC +WG + C+E++N G GNCGK K ++ +C RD CG + C
Sbjct: 547 CKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGK-DKDTWIQCNKRDVLCGYLLC 605
Query: 586 QGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICL 645
+ P +G I + + +QQG + C G HV L +D+ D G V GT C +CL
Sbjct: 606 TNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDV-DLGYVEDGTPCGPQMMCL 664
Query: 646 NRQCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFCDKF 690
+C ++ F C C G GVC+N C C HW C+ +
Sbjct: 665 EHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTY 714
>gi|50845382 ADAM metallopeptidase domain 20 preproprotein [Homo
sapiens]
Length = 776
Score = 362 bits (929), Expect = e-100
Identities = 223/689 (32%), Positives = 340/689 (49%), Gaps = 50/689 (7%)
Query: 30 GVSLWNQGRADEVVSASVGSGDLWIPVKSFD---SKNHPEVLNIRLQRESKELIINLERN 86
G+ L G + S S ++ IP+K P L+ L+ + I+++ N
Sbjct: 70 GMFLSISGHSQARPSQYFTSPEVVIPLKVISRGRGAKAPGWLSYSLRFGGQRYIVHMRVN 129
Query: 87 EGLIAS-----SFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSG- 140
+ L A+ ++TE H +L ++ I CYYHG+V G +S V+LSTCSG
Sbjct: 130 KLLFAAHLPVFTYTEQH--------ALLQDQPFIQDDCYYHGYVEGVPESLVALSTCSGG 181
Query: 141 LRGLIVFENESYVLEPMK-SATNRYKLFP--AKKLKSVRGSCG------SHHNTPNLAAK 191
G++ + Y ++P+ SAT + ++ + + CG +H L+
Sbjct: 182 FLGMLQINDLVYEIKPISVSATFEHLVYKIDSDDTQFPPMRCGLTEEKIAHQMELQLSYN 241
Query: 192 NVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKF 251
S H+R +VELV+V DN + + V+ + + N VD F
Sbjct: 242 FTLKQSSFVGWWTHQR-------FVELVVVVDNIRYLFSQSNATTVQHEVFNVVNIVDSF 294
Query: 252 YRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYF 311
Y PL + ++L G+++W + S D L +F W+ L R HD A L
Sbjct: 295 YHPLEVDVILTGIDIWTASNPLPTSGDLDNVLEDFSIWKNYNLNNRLQHDVAHLFIKDT- 353
Query: 312 QGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQM 371
QG +G+A + +C + G+ + + + A+TL HELGHN GM HDT + C C++
Sbjct: 354 QGMKLGVAYVKGICQNPFNTGVDVFEDNRLVVFAITLGHELGHNLGMQHDT--QWCVCEL 411
Query: 372 AVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRF 431
CIM+A FS+CS S G+C+ P F + CGN
Sbjct: 412 Q----WCIMHAYR--KVTTKFSNCSYAQYWDSTISS-GLCIQPPPYPGNIFRLKYCGNLV 464
Query: 432 VEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDL 491
VEEGEECDCG +C C CTL P A CA G+CC+DC+ P+GT CR CDL
Sbjct: 465 VEEGEECDCGTIRQCAKDPCCLLNCTLHPGAACAFGICCKDCKFLPSGTLCRQQVGECDL 524
Query: 492 PEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFER 551
PE+C G S CP +VY+ DG SC +V+ +CY C H+ QC ++G A+ A C++
Sbjct: 525 PEWCNGTSHQCPDDVYVQDGISC-NVNAFCYEKTCNNHDIQCKEIFGQDARSASQSCYQE 583
Query: 552 VNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGG 611
+N+ G+ +G+CG V +++ KC D CG++QC+ P + ++ + ++
Sbjct: 584 INTQGNRFGHCGIVG-TTYVKCWTPDIMCGRVQCENVGVIPNLIEHSTVQQFHL-----N 637
Query: 612 RILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCN 671
C GT +LG +PD G V GT C KIC+ ++C ++ C+ RG+CN
Sbjct: 638 DTTCWGTDYHLGMAIPDIGEVKDGTVCGPEKICIRKKCASMVHLSQACQPKTCNMRGICN 697
Query: 672 NRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
N+++CHC WAPP+C G+GGS DSGP
Sbjct: 698 NKQHCHCNHEWAPPYCKDKGYGGSADSGP 726
>gi|195232763 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 355 bits (910), Expect = 1e-97
Identities = 214/669 (31%), Positives = 336/669 (50%), Gaps = 53/669 (7%)
Query: 51 DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
D+ IPV+ + P L+ L ++ II+++ + L + Y G +
Sbjct: 32 DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88
Query: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
+ + + +CYYHG+V G +S VSLSTC G +G++ + +Y ++P+ +T
Sbjct: 89 ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148
Query: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
YK+ K+ ++R + T + + + T K + Y
Sbjct: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196
Query: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
VE+V+V DN + R ++ K+ + L I N VD + ++++L G+E+W + +
Sbjct: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255
Query: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
V D S+H + W+ + PR HD + L + + +G + G+ MCT +S
Sbjct: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314
Query: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
IV + ++ +AH LGHN GMNHD + C C + CIM+ G P F
Sbjct: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366
Query: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
S+CS D E ++E+ CL ++ F ++CGN VEEGEECDCG + C C
Sbjct: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424
Query: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
+ CTL + CA GLCC+DC+ P+G CR N CDLPE+C G S CP + Y+ DG
Sbjct: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484
Query: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
C++ GYCY C +QC ++G GA A C++ +N+ GD G+CG + +++
Sbjct: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542
Query: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
KC + D +CG+IQC+ P +S T + + I+C T +LG PD G
Sbjct: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
Query: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
V GT+C IC++R C +I++ + C+ RG+CNN+ +CHC W PP C G
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
Query: 692 FGGSTDSGP 700
+GGS DSGP
Sbjct: 658 YGGSVDSGP 666
>gi|195232761 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 355 bits (910), Expect = 1e-97
Identities = 214/669 (31%), Positives = 336/669 (50%), Gaps = 53/669 (7%)
Query: 51 DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
D+ IPV+ + P L+ L ++ II+++ + L + Y G +
Sbjct: 32 DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88
Query: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
+ + + +CYYHG+V G +S VSLSTC G +G++ + +Y ++P+ +T
Sbjct: 89 ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148
Query: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
YK+ K+ ++R + T + + + T K + Y
Sbjct: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196
Query: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
VE+V+V DN + R ++ K+ + L I N VD + ++++L G+E+W + +
Sbjct: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255
Query: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
V D S+H + W+ + PR HD + L + + +G + G+ MCT +S
Sbjct: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314
Query: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
IV + ++ +AH LGHN GMNHD + C C + CIM+ G P F
Sbjct: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366
Query: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
S+CS D E ++E+ CL ++ F ++CGN VEEGEECDCG + C C
Sbjct: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424
Query: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
+ CTL + CA GLCC+DC+ P+G CR N CDLPE+C G S CP + Y+ DG
Sbjct: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484
Query: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
C++ GYCY C +QC ++G GA A C++ +N+ GD G+CG + +++
Sbjct: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542
Query: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
KC + D +CG+IQC+ P +S T + + I+C T +LG PD G
Sbjct: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
Query: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
V GT+C IC++R C +I++ + C+ RG+CNN+ +CHC W PP C G
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
Query: 692 FGGSTDSGP 700
+GGS DSGP
Sbjct: 658 YGGSVDSGP 666
>gi|195232759 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 355 bits (910), Expect = 1e-97
Identities = 214/669 (31%), Positives = 336/669 (50%), Gaps = 53/669 (7%)
Query: 51 DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
D+ IPV+ + P L+ L ++ II+++ + L + Y G +
Sbjct: 32 DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88
Query: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
+ + + +CYYHG+V G +S VSLSTC G +G++ + +Y ++P+ +T
Sbjct: 89 ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148
Query: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
YK+ K+ ++R + T + + + T K + Y
Sbjct: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196
Query: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
VE+V+V DN + R ++ K+ + L I N VD + ++++L G+E+W + +
Sbjct: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255
Query: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
V D S+H + W+ + PR HD + L + + +G + G+ MCT +S
Sbjct: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314
Query: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
IV + ++ +AH LGHN GMNHD + C C + CIM+ G P F
Sbjct: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366
Query: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
S+CS D E ++E+ CL ++ F ++CGN VEEGEECDCG + C C
Sbjct: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424
Query: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
+ CTL + CA GLCC+DC+ P+G CR N CDLPE+C G S CP + Y+ DG
Sbjct: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484
Query: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
C++ GYCY C +QC ++G GA A C++ +N+ GD G+CG + +++
Sbjct: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542
Query: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
KC + D +CG+IQC+ P +S T + + I+C T +LG PD G
Sbjct: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
Query: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
V GT+C IC++R C +I++ + C+ RG+CNN+ +CHC W PP C G
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
Query: 692 FGGSTDSGP 700
+GGS DSGP
Sbjct: 658 YGGSVDSGP 666
>gi|73765552 ADAM metallopeptidase domain 29 preproprotein [Homo
sapiens]
Length = 820
Score = 355 bits (910), Expect = 1e-97
Identities = 214/669 (31%), Positives = 336/669 (50%), Gaps = 53/669 (7%)
Query: 51 DLWIPVK---SFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVS 107
D+ IPV+ + P L+ L ++ II+++ + L + Y G +
Sbjct: 32 DVVIPVRITGTTRGMTPPGWLSYILPFGGQKHIIHIKVKKLLFSKHLPVFTYTDQG---A 88
Query: 108 LARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFENESYVLEPMKSATN---- 162
+ + + +CYYHG+V G +S VSLSTC G +G++ + +Y ++P+ +T
Sbjct: 89 ILEDQPFVQNNCYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHL 148
Query: 163 RYKL-FPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKY------ 215
YK+ K+ ++R + T + + + T K + Y
Sbjct: 149 VYKMDSEEKQFSTMRSGFMQNEITCRMEFEEI------------DNSTQKQSSYVGWWIH 196
Query: 216 ---VELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDK 272
VE+V+V DN + R ++ K+ + L I N VD + ++++L G+E+W + +
Sbjct: 197 FRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIGVKVLLFGLEIWTNKN- 255
Query: 273 CSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG 332
V D S+H + W+ + PR HD + L + + +G + G+ MCT +S
Sbjct: 256 LIVVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLS-GIGAFRGMCTPHRSCA 314
Query: 333 IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVF 392
IV + ++ +AH LGHN GMNHD + C C + CIM+ G P F
Sbjct: 315 IVTFMNKTLGTFSIAVAHHLGHNLGMNHD--EDTCRC----SQPRCIMH--EGNPPITKF 366
Query: 393 SSCSRKDL-ETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCC 451
S+CS D E ++E+ CL ++ F ++CGN VEEGEECDCG + C C
Sbjct: 367 SNCSYGDFWEYTVERTK--CLLETVHTKDIFNVKRCGNGVVEEGEECDCGPLKHCAKDPC 424
Query: 452 NATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDG 511
+ CTL + CA GLCC+DC+ P+G CR N CDLPE+C G S CP + Y+ DG
Sbjct: 425 CLSNCTLTDGSTCAFGLCCKDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDG 484
Query: 512 HSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFA 571
C++ GYCY C +QC ++G GA A C++ +N+ GD G+CG + +++
Sbjct: 485 IPCKE-RGYCYEKSCHDRNEQCRRIFGAGANTASETCYKELNTLGDRVGHCG-IKNATYI 542
Query: 572 KCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGL 631
KC + D +CG+IQC+ P +S T + + I+C T +LG PD G
Sbjct: 543 KCNISDVQCGRIQCENVTEIP-----NMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGE 597
Query: 632 VLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFG 691
V GT+C IC++R C +I++ + C+ RG+CNN+ +CHC W PP C G
Sbjct: 598 VKDGTECGIDHICIHRHCVHITILNSNCSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKG 657
Query: 692 FGGSTDSGP 700
+GGS DSGP
Sbjct: 658 YGGSVDSGP 666
>gi|4501913 ADAM metallopeptidase domain 23 preproprotein [Homo
sapiens]
Length = 832
Score = 354 bits (909), Expect = 1e-97
Identities = 212/645 (32%), Positives = 307/645 (47%), Gaps = 44/645 (6%)
Query: 64 HPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHG 123
H + +++ + I++L N GL++S + E HY S HCYYHG
Sbjct: 147 HLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPQYSKGGE------HCYYHG 200
Query: 124 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMK-----SATNRYKLFPAKKLKSVRGS 178
+RG DS V+LSTC+GL G+ + Y++EP++ +T R + K++ G
Sbjct: 201 SIRGVKDSKVALSTCNGLHGMFEDDTFVYMIEPLELVHDEKSTGRPHIIQ----KTLAGQ 256
Query: 179 CGSHHNTPNLAAKNVFPPPSQT-WARRHKRET------LKATKYVELVIVADNREFQRQG 231
+ + +P S+ W +R KR + KY+EL+IV D++ +++
Sbjct: 257 YSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHR 316
Query: 232 KDLEKVKQRLIEIANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWR 290
+ N VD Y+ LN R+VLV VE W + D+ ++ +P LHEF +R
Sbjct: 317 SSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITTNPVQMLHEFSKYR 376
Query: 291 KMKLLPRKSH-DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLA 349
+ K H D L+S V F ++ +C+ ++ G+ ++ P+ A L+
Sbjct: 377 QRI----KQHADAVHLISRVTFHYKRSSLSYFGGVCS--RTRGVGVNEYGLPMAVAQVLS 430
Query: 350 HELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMG 409
L N G+ + R C GGCIM TG FS CS + L++G G
Sbjct: 431 QSLAQNLGIQWEPSSRKPKCDCTESWGGCIME-ETGVSHSRKFSKCSILEYRDFLQRGGG 489
Query: 410 VCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLC 469
CLFN P + F +CGN +VE GEECDCG EC CC C+L A C+ G C
Sbjct: 490 ACLFNRPT--KLFEPTECGNGYVEAGEECDCGFHVECYGLCCKK--CSLSNGAHCSDGPC 545
Query: 470 CED--CQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQ 527
C + C +P G CRD+ N CD+ E+CTG S CP N++ DG++C G CYNG C+
Sbjct: 546 CNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECK 605
Query: 528 THEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQG 587
T + QC +WG A + C+E++N+ G GNCGK + +C D CG + C
Sbjct: 606 TRDNQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCGK-DGDRWIQCSKHDVFCGFLLCTN 664
Query: 588 GASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNR 647
P IG I QG I C G HV L DD D G V GT C +CL+R
Sbjct: 665 LTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDD-TDVGYVEDGTPCGPSMMCLDR 723
Query: 648 QCQNISVFGVHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFC 687
+C I + C + C G GVC+N C C+ WA C
Sbjct: 724 KCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDC 768
>gi|54292117 ADAM metallopeptidase domain 28 isoform 3 preproprotein
[Homo sapiens]
Length = 540
Score = 351 bits (901), Expect = 1e-96
Identities = 185/494 (37%), Positives = 271/494 (54%), Gaps = 32/494 (6%)
Query: 68 LNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRG 127
L ++ K ++ L++N+ L+A +TET+Y G +++ + I+ CYY GH+
Sbjct: 57 LKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNSTGKEITTSPQ---IMDDCYYQGHILN 113
Query: 128 YSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNR-------YKLFPAKKLKSVRGSCG 180
S S+STC GLRG ++ Y +EP+ S +R +K P +K + +CG
Sbjct: 114 EKVSDASISTCRGLRGYFSQGDQRYFIEPL-SPIHRDGQEHALFKYNPDEK--NYDSTCG 170
Query: 181 ------SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDL 234
+H N+A P+ + R+ + KY+E +V DN EF+R ++
Sbjct: 171 MDGVLWAHDLQQNIAL------PATKLVKLKDRKVQEHEKYIEYYLVLDNGEFKRYNENQ 224
Query: 235 EKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKL 294
+++++R+ E+AN+V+ Y+ LN + LVG+E+W D DK ++ + +L F WR L
Sbjct: 225 DEIRKRVFEMANYVNMLYKKLNTHVALVGMEIWTDKDKIKITPNASFTLENFSKWRGSVL 284
Query: 295 LPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGH 354
RK HD AQL++ GTT+G+A + +MC+ S G+V DHSDN L A T+AHE+GH
Sbjct: 285 SRRKRHDIAQLITATELAGTTVGLAFMSTMCSP-YSVGVVQDHSDNLLRVAGTMAHEMGH 343
Query: 355 NFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFN 414
NFGM HD D C C + C+M+ + + P FSSCSR + E + CLFN
Sbjct: 344 NFGMFHD--DYSCKCPSTI----CVMDKALSFYIPTDFSSCSRLSYDKFFEDKLSNCLFN 397
Query: 415 LPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQ 474
P + CGN+ VE GE+CDCG EEC N CC+A TC +K CA G CCE CQ
Sbjct: 398 APLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKIKATFQCALGECCEKCQ 457
Query: 475 LKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCV 534
K AG CR + + CDLPE C G S +CP + + +G C G+C G C T ++QC
Sbjct: 458 FKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLMGTCPTLQEQCT 517
Query: 535 TLWGPGAKPAPGIC 548
LWGPG + P C
Sbjct: 518 ELWGPGRRTNPFPC 531
>gi|11497040 ADAM metallopeptidase domain 21 preproprotein [Homo
sapiens]
Length = 722
Score = 351 bits (901), Expect = 1e-96
Identities = 224/695 (32%), Positives = 347/695 (49%), Gaps = 63/695 (9%)
Query: 30 GVSLWNQGRADEVVSASVGSGDLWIPVKSFD---SKNHPEVLNIRLQRESKELIINLERN 86
GV L G S S ++ IP+K S P L+ L+ ++ ++++
Sbjct: 20 GVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYSLRFGGQKHVVHMRVK 79
Query: 87 EGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLI 145
+ L++ Y + +L + I CYYHG+V G +S V S C G RG++
Sbjct: 80 KLLVSRHLPVFTYTDER---ALLEDQLFIPDDCYYHGYVEGAPESLVVFSACFGGFRGVL 136
Query: 146 VFENESYVLEPMK-SATNR---YKL------FPAKKLKSVRGSCGSHHNTPNLAAKNVFP 195
+Y +EP++ SAT YK+ FPA + A +
Sbjct: 137 KISGLTYEIEPIRHSATFEHLVYKVNSNETQFPAMRCGLTEKEVARQQLEFEEAENSALE 196
Query: 196 PPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPL 255
P S H ++ELV+V ++ F ++ KV++ + + N VD Y+ L
Sbjct: 197 PKSAGDWWTH-------AWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYQQL 249
Query: 256 NIRIVLVGVEVWNDMDKCSVSQDPFTS----LHEFLDWRKMKLLPRKSHDNAQLVSGVYF 311
I+L+G+E+WN + P TS L++F W+++ L + HD A + +
Sbjct: 250 GTYIILIGIEIWNQGNVF-----PMTSIEQVLNDFSQWKQISL-SQLQHDAAHM----FI 299
Query: 312 QGTTI---GMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCS 368
+ + I G+A + +C G+ D A T+AHELGH GM HD + C
Sbjct: 300 KNSLISILGLAYVAGICRPPIDCGVDNFQGDTWSLFANTVAHELGHTLGMQHD--EEFCF 357
Query: 369 CQMAVEKGGCIMNASTGYPFPMV-FSSCSRKD-LETSLEKGMGVCLFNLPEVRESFGGQK 426
C + GCIMN + P F++CS D ++T+L +G CL N P + E F ++
Sbjct: 358 CG----ERGCIMNT---FRVPAEKFTNCSYADFMKTTLNQGS--CLHNPPRLGEIFMLKR 408
Query: 427 CGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS 486
CGN VE E+CDCG ++C C CTL+P A CA GLCC+DC+ P+G CR
Sbjct: 409 CGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAFGLCCKDCKFMPSGELCRQEV 468
Query: 487 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG 546
N CDLPE+C G S CP + Y+ DG C D YCY C H+Q C ++G AK A
Sbjct: 469 NECDLPEWCNGTSHQCPEDRYVQDGIPCSD-SAYCYQKRCNNHDQHCREIFGKDAKSASQ 527
Query: 547 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP 606
C++ +NS G+ +G+CG ++ +++ KC + D CG++QC+ P++ + T+I
Sbjct: 528 NCYKEINSQGNRFGHCG-INGTTYLKCHISDVFCGRVQCENVRDIPLLQDHFTLQHTHI- 585
Query: 607 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ-CH 665
+ C G +L ++ D G V GT C GKIC++++C ++SV H C + C+
Sbjct: 586 ----NGVTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLS-HVCLPETCN 640
Query: 666 GRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGP 700
+G+CNN+ +CHC W+PP+C G+GGS DSGP
Sbjct: 641 MKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGP 675
>gi|31881770 ADAM metallopeptidase domain 30 preproprotein [Homo
sapiens]
Length = 790
Score = 349 bits (896), Expect = 5e-96
Identities = 221/679 (32%), Positives = 338/679 (49%), Gaps = 53/679 (7%)
Query: 46 SVGSGDLWIPVKSFDSKNH--PEVLNIR-------------LQRESKELIINLERNEGLI 90
S+G ++ P FDS PE L+ R LQ + K+ +++L L+
Sbjct: 25 SLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLL 84
Query: 91 ASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTC-SGLRGLIVFEN 149
+ + G L ++ I C Y G V+ DS ++STC GLRG+ +
Sbjct: 85 PRHLRVFSFTEHG---ELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDA 141
Query: 150 ESYVLEPMKSATN-RYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWAR-RHKR 207
+ Y +EP+K++ + + ++ KK + CG + P + AR R
Sbjct: 142 KHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMA-----PYENKARLRDFP 196
Query: 208 ETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVW 267
+ K KY+EL+++ D ++ +L +V I + +D +++ + +RI L +EVW
Sbjct: 197 GSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVW 256
Query: 268 NDMDKCSVSQDPFTS-LHEFLDWRKMKLLPRKSHDNAQL-VSGVYFQGTTIGMAPIMSMC 325
D +K V L F+ ++K L R S D A L + Y + C
Sbjct: 257 TDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKV---C 313
Query: 326 TADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNAS-T 384
+ + +G + N L A AHELGH GM+HD ++ C C+ + CIM + T
Sbjct: 314 SLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHD--EQYCQCRGRLN---CIMGSGRT 368
Query: 385 GYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPE 444
G FS+CS + G CL N+P + + ++CGN+ VE+ EECDCG E
Sbjct: 369 G------FSNCSYISFFKHISSG-ATCLNNIPGL--GYVLKRCGNKIVEDNEECDCGSTE 419
Query: 445 ECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPA 504
EC C + C L+P A C+ GLCC DC+ +P+G CR N CDL E+C G S CP
Sbjct: 420 ECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPN 479
Query: 505 NVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGK 564
+VY DG C+ +G C+ C++ QC +++GP A AP C++ VN GD +GNC
Sbjct: 480 DVYKQDGTPCK-YEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEI 538
Query: 565 VSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLG- 623
+F KCE ++ CG++QC + P + + I T++ Q ++C GT +L
Sbjct: 539 TGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHL---QAENLMCWGTGYHLSM 595
Query: 624 --DDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAH 681
+PD G++ GT C +G++C + C N SV +C+ RGVCNNRKNCHC
Sbjct: 596 KPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYG 655
Query: 682 WAPPFCDKFGFGGSTDSGP 700
WAPPFC++ G+GGS DSGP
Sbjct: 656 WAPPFCEEVGYGGSIDSGP 674
>gi|4585710 ADAM metallopeptidase domain 11 preproprotein [Homo
sapiens]
Length = 769
Score = 340 bits (872), Expect = 3e-93
Identities = 220/636 (34%), Positives = 308/636 (48%), Gaps = 54/636 (8%)
Query: 81 INLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSG 140
++LE N L++S + E H+ ++GT ++ T HCYY G +RG S +LSTC G
Sbjct: 99 LDLELNHHLLSSQYVERHFSREGT----TQHSTGAGDHCYYQGKLRGNPHSFAALSTCQG 154
Query: 141 LRGLIVFENESYVLEPMKSATN--------RYKLFPAKKLKSVRG--SCGSHHNTPNLAA 190
L G+ N +Y++EP + A + ++ L G G P +A
Sbjct: 155 LHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSA 214
Query: 191 KNVFPPPSQTWARRHKRETLKA-------TKYVELVIVADNREFQRQGKDLEKVKQRLIE 243
PP++ RR KR+ + TKYVEL+++ D++ F++ + +
Sbjct: 215 -----PPNRPRLRR-KRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKS 268
Query: 244 IANHVDKFYRP-LNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDN 302
+ N D Y+ LN RIVLV +E W D DK V D +L + +R+ + LP S D
Sbjct: 269 VVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRR-EGLPEPS-DA 326
Query: 303 AQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGM---N 359
L SG FQ T+ G A + +C+ GG+ + N AVTLA LG N GM
Sbjct: 327 THLFSGRTFQSTSSGAAYVGGICSLSHGGGV--NEYGNMGAMAVTLAQTLGQNLGMMWNK 384
Query: 360 HDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVR 419
H + C C GCIM TG+ P FS CS + L++G G CLFN P
Sbjct: 385 HRSSAGDCKCPDIWL--GCIME-DTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKP--L 439
Query: 420 ESFGGQKCGNRFVEEGEECDCGEPEECMN---RCCNATTCTLKPDAVCAHGLCCEDCQLK 476
+ +CGN FVE GEECDCG +EC CC CTL DA+C+ GLCC C+ +
Sbjct: 440 KLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKK--CTLTHDAMCSDGLCCRRCKYE 497
Query: 477 PAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTL 536
P G +CR++ N CD+ E CTG S CP N++ DG+ C G CY G C+T ++QC L
Sbjct: 498 PRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVL 557
Query: 537 WGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGT 596
WG A A C+E++N G G+CG+ S + +C +D CG + C + P +G
Sbjct: 558 WGHAA--ADRFCYEKLNVEGTERGSCGR-KGSGWVQCSKQDVLCGFLLCVNISGAPRLGD 614
Query: 597 NAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFG 656
I + QG + CRG HV L D D V GT C +CL+ +C S F
Sbjct: 615 LVGDISSVTFYHQGKELDCRGGHVQLADG-SDLSYVEDGTACGPNMLCLDHRCLPASAFN 673
Query: 657 VHECAMQ-----CHGRGVCNNRKNCHCEAHWAPPFC 687
C C GVC+N C C+ W C
Sbjct: 674 FSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDC 709
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,693,601
Number of Sequences: 37866
Number of extensions: 1580480
Number of successful extensions: 4891
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 178
Number of HSP's that attempted gapping in prelim test: 3914
Number of HSP's gapped (non-prelim): 770
length of query: 738
length of database: 18,247,518
effective HSP length: 110
effective length of query: 628
effective length of database: 14,082,258
effective search space: 8843658024
effective search space used: 8843658024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.