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Search of human proteins with 71773324
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 870 0.0
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 852 0.0
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 852 0.0
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 639 0.0
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 639 0.0
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 471 e-133
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 471 e-133
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 471 e-133
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 470 e-133
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 470 e-133
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 141 1e-33
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 136 3e-32
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 131 1e-30
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 128 9e-30
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 127 1e-29
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 127 1e-29
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 127 1e-29
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 127 2e-29
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 121 1e-27
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 120 2e-27
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 119 5e-27
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 112 6e-25
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 108 7e-24
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 108 9e-24
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 89 6e-18
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 72 1e-12
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 71 2e-12
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 71 2e-12
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 71 2e-12
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 37 0.035
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 870 bits (2249), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKATQLDS 60
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKATQLDS
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKATQLDS 60
Query: 61 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 120
AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY
Sbjct: 61 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 120
Query: 121 VDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPC 180
VDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPC
Sbjct: 121 VDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPC 180
Query: 181 YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQ 240
YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQ
Sbjct: 181 YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQ 240
Query: 241 SSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFG 300
SSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFG
Sbjct: 241 SSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFG 300
Query: 301 PILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTL 360
PILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTL
Sbjct: 301 PILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTL 360
Query: 361 ASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVA 420
ASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVA
Sbjct: 361 ASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVA 420
Query: 421 MEAQGCSCTLL 431
MEAQGCSCTLL
Sbjct: 421 MEAQGCSCTLL 431
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 852 bits (2201), Expect = 0.0
Identities = 431/468 (92%), Positives = 431/468 (92%), Gaps = 37/468 (7%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
Query: 55 -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83
ATQLDSAFIRKEPFGLVLIIAPWNYPLNL
Sbjct: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
Query: 84 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
Query: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
Query: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
Query: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
Query: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
Query: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 431
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 852 bits (2201), Expect = 0.0
Identities = 431/468 (92%), Positives = 431/468 (92%), Gaps = 37/468 (7%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
Query: 55 -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83
ATQLDSAFIRKEPFGLVLIIAPWNYPLNL
Sbjct: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
Query: 84 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143
TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
Query: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203
FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
Query: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263
GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
Query: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
Query: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
Query: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 431
TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL 468
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 639 bits (1647), Expect = 0.0
Identities = 316/375 (84%), Positives = 341/375 (90%), Gaps = 2/375 (0%)
Query: 57 QLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV 116
+LDS FI KEPFGLVLIIAPWNYPLNLTLV LVGALAAG+CVVLKPSEIS+ EK+LAEV
Sbjct: 13 KLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEV 72
Query: 117 LPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGG 176
LPQY+DQSCFAVVLGGPQETGQLLEH+ DYIFFTGSPRVGKIVMTAA KHLTPVTLELGG
Sbjct: 73 LPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGG 132
Query: 177 KNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG 236
KNPCYVDDNCDPQTVANRVAWF YFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG
Sbjct: 133 KNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG 192
Query: 237 DDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQE 296
DDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQS+ESDRYIAPTVLVDVQE EPVMQE
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDVQETEPVMQE 252
Query: 297 EIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFM 356
EIFGPILPIVNVQS+DEAI+FINR+EKPLALYAFSNSSQVV ++L +TSSG F GN+GF
Sbjct: 253 EIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGGNEGFT 312
Query: 357 HMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRRLRM 416
+++L S+PFGGVG SGMGRYHGKF+FDTFSHHR CLL G+EKL + YPP + ++
Sbjct: 313 YISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHYPPYTDWNQQL 372
Query: 417 LLVAMEAQGCSCTLL 431
L M +Q SCTLL
Sbjct: 373 LRWGMGSQ--SCTLL 385
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 639 bits (1647), Expect = 0.0
Identities = 316/375 (84%), Positives = 341/375 (90%), Gaps = 2/375 (0%)
Query: 57 QLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV 116
+LDS FI KEPFGLVLIIAPWNYPLNLTLV LVGALAAG+CVVLKPSEIS+ EK+LAEV
Sbjct: 13 KLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEV 72
Query: 117 LPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGG 176
LPQY+DQSCFAVVLGGPQETGQLLEH+ DYIFFTGSPRVGKIVMTAA KHLTPVTLELGG
Sbjct: 73 LPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGG 132
Query: 177 KNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG 236
KNPCYVDDNCDPQTVANRVAWF YFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG
Sbjct: 133 KNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG 192
Query: 237 DDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQE 296
DDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQS+ESDRYIAPTVLVDVQE EPVMQE
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDVQETEPVMQE 252
Query: 297 EIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFM 356
EIFGPILPIVNVQS+DEAI+FINR+EKPLALYAFSNSSQVV ++L +TSSG F GN+GF
Sbjct: 253 EIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGGNEGFT 312
Query: 357 HMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRRLRM 416
+++L S+PFGGVG SGMGRYHGKF+FDTFSHHR CLL G+EKL + YPP + ++
Sbjct: 313 YISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHYPPYTDWNQQL 372
Query: 417 LLVAMEAQGCSCTLL 431
L M +Q SCTLL
Sbjct: 373 LRWGMGSQ--SCTLL 385
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 471 bits (1211), Expect = e-133
Identities = 233/451 (51%), Positives = 309/451 (68%), Gaps = 38/451 (8%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 55 -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83
TQ D +I EP G+VL+I WNYP NL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 84 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 414
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 471 bits (1211), Expect = e-133
Identities = 233/451 (51%), Positives = 309/451 (68%), Gaps = 38/451 (8%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 55 -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83
TQ D +I EP G+VL+I WNYP NL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 84 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 414
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 471 bits (1211), Expect = e-133
Identities = 233/451 (51%), Positives = 309/451 (68%), Gaps = 38/451 (8%)
Query: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 55 -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83
TQ D +I EP G+VL+I WNYP NL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 84 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 414
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 470 bits (1210), Expect = e-133
Identities = 232/444 (52%), Positives = 308/444 (69%), Gaps = 37/444 (8%)
Query: 8 LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKA------------ 55
+RR+R+AF +GR+RP FR QL+ L R +QE ++ + A+A DL K+
Sbjct: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
Query: 56 -------------------------TQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 90
T LD A+I+ +P G+VLII WNYP LT+ PL+G
Sbjct: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
Query: 91 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 150
A+AAGN V++KPSE+S+N KILA++LPQY+DQ + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
Query: 151 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 210
G+ VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD V R+ W +Y N GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
Query: 211 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 270
DY+LC +Q +++ ++ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
Query: 271 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 330
++DE+ RYIAPTVL DV VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
Query: 331 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 390
S++ +++KR++ +TSSGG GND MH TL S PFGGVG+SGMG YHGK SFDTFSH R
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
Query: 391 CLLRSPGMEKLNALRYPPQSPRRL 414
CLL+S E N LRYPP S ++
Sbjct: 425 CLLKSLKREGANKLRYPPNSQSKV 448
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 470 bits (1210), Expect = e-133
Identities = 232/444 (52%), Positives = 308/444 (69%), Gaps = 37/444 (8%)
Query: 8 LRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKA------------ 55
+RR+R+AF +GR+RP FR QL+ L R +QE ++ + A+A DL K+
Sbjct: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
Query: 56 -------------------------TQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVG 90
T LD A+I+ +P G+VLII WNYP LT+ PL+G
Sbjct: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
Query: 91 ALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFT 150
A+AAGN V++KPSE+S+N KILA++LPQY+DQ + V+ GG +ET +LL+ RFD+IF+T
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
Query: 151 GSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAP 210
G+ VGKIVM AAAKHLTPVTLELGGK+PCY+D +CD V R+ W +Y N GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
Query: 211 DYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGG 270
DY+LC +Q +++ ++ T+ FYG++ + SP+ RIIN + F+R+ +LL ++A GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
Query: 271 QSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAF 330
++DE+ RYIAPTVL DV VMQEEIFGPILPIV V+++DEAI FIN REKPLALY F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
Query: 331 SNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRA 390
S++ +++KR++ +TSSGG GND MH TL S PFGGVG+SGMG YHGK SFDTFSH R
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
Query: 391 CLLRSPGMEKLNALRYPPQSPRRL 414
CLL+S E N LRYPP S ++
Sbjct: 425 CLLKSLKREGANKLRYPPNSQSKV 448
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 141 bits (356), Expect = 1e-33
Identities = 105/344 (30%), Positives = 166/344 (48%), Gaps = 13/344 (3%)
Query: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
F R EP G+ I PWN+PL + + L AL GN +VLKP+E + L ++ +
Sbjct: 165 FTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAG 224
Query: 121 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 177
+V G GP + H + + I FTGS VGK+V AA++ +L VTLELGGK
Sbjct: 225 FPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGK 284
Query: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEM-QERLLPALQSTITRFYG 236
NPC V + D +FN GQ C A V ++ E + +++ R G
Sbjct: 285 NPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVG 344
Query: 237 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 290
D G I+QKQF ++ L+ G ++ GG + ++ +I PTV +V +
Sbjct: 345 DPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDN 404
Query: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
+ +EEIFGP+ PI+ +S++E I+ N + L F+ + ++ + SG
Sbjct: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
Query: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLR 394
N + A PFGG SG GR G+++ ++ + ++
Sbjct: 465 IN--CYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 136 bits (343), Expect = 3e-32
Identities = 100/341 (29%), Positives = 155/341 (45%), Gaps = 19/341 (5%)
Query: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
+ R+EP G+ + I WNYP + ALA GN +V KPS + +LAE+ +
Sbjct: 165 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 224
Query: 121 VDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELGGKN 178
V F VV GG TGQ L D + FTGS G +M +AK + PVTLELGGK+
Sbjct: 225 VPPGLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 283
Query: 179 PCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YGD 237
P + +CD + GQ C V E+ ++ + R GD
Sbjct: 284 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 343
Query: 238 DPQSSPNLGRIINQKQFQRLRALLGC-----GRVAIGGQ-------SDESDRYIAPTVLV 285
+G +IN+ +R+ + +V GG + Y+ P VL
Sbjct: 344 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 403
Query: 286 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 345
+ ++ ++EEIFGP++ I++ + E +E N LA F+ Q RV+ +
Sbjct: 404 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 463
Query: 346 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 386
+G N+ +++ LPFGG SG GR +G+ + + +S
Sbjct: 464 AGTCFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYS 502
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 131 bits (329), Expect = 1e-30
Identities = 101/349 (28%), Positives = 165/349 (47%), Gaps = 18/349 (5%)
Query: 52 LHKATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEK 111
+H + A + K+P G+ +I PWN+P + + ALAAG VV+KP+E +
Sbjct: 179 IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSAL 238
Query: 112 ILAEVLPQY-VDQSCFAVV---LGGPQETGQLL--EHRFDYIFFTGSPRVGKIVMTAAAK 165
LAE+ Q + + V+ +E G+ + + I FTGS GKI++ AA
Sbjct: 239 ALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 298
Query: 166 HLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL 224
+ V++ELGG P V D+ + Q VA +A ++ N GQTCV + L + + +
Sbjct: 299 SVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDAFV 357
Query: 225 PALQSTITR--FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSDE-SD 276
A + + G+ + G +IN+K +++ A+ V GG+ +
Sbjct: 358 KAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGK 417
Query: 277 RYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQV 336
+ PT+L +V + EE FGP+ P++ + +EAI N + LA Y +S
Sbjct: 418 NFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQ 477
Query: 337 VKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 385
+ RV Q G N+G ++ PFGGV SG+GR K+ D +
Sbjct: 478 IWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 524
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 128 bits (322), Expect = 9e-30
Identities = 104/362 (28%), Positives = 166/362 (45%), Gaps = 31/362 (8%)
Query: 52 LHKATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEK 111
+H + A + K+P G+ +I PWN+P + + ALAAG VV+KP+E +
Sbjct: 179 IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSAL 238
Query: 112 ILAEVLPQY---VDQSCFAVVLGGP--------------QETGQLL--EHRFDYIFFTGS 152
LAEV + +D A G P +E G+ + + I FTGS
Sbjct: 239 ALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGS 298
Query: 153 PRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPD 211
GKI++ AA + V++ELGG P V D+ + Q VA +A ++ N GQTCV +
Sbjct: 299 TTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSN 357
Query: 212 YVLCSPEMQERLLPALQSTITR--FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCG 264
L + + + A + + G+ + G +IN+K +++ A+
Sbjct: 358 QFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGA 417
Query: 265 RVAIGGQSDE-SDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
V GG+ + + PT+L +V + EE FGP+ P++ + +EAI N +
Sbjct: 418 TVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV 477
Query: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
LA Y +S + RV Q G N+G ++ PFGGV SG+GR K+ D
Sbjct: 478 GLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGID 535
Query: 384 TF 385
+
Sbjct: 536 EY 537
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 127 bits (320), Expect = 1e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
Query: 121 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 177
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
Query: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 236
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
Query: 237 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 290
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
Query: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374
Query: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 375 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 418
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 127 bits (320), Expect = 1e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
Query: 121 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 177
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
Query: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 236
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
Query: 237 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 290
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
Query: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470
Query: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 471 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 514
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 127 bits (320), Expect = 1e-29
Identities = 105/361 (29%), Positives = 174/361 (48%), Gaps = 37/361 (10%)
Query: 54 KATQLDSA----FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNV 109
+ TQ+D + + P G+ +I+PWN PL L + A+AAGN V+ KPSE++
Sbjct: 127 ECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVT 186
Query: 110 EKILAEVLPQY-VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAKH 166
+L ++L + V +V G GP+ L+ H I FTGS + + +A H
Sbjct: 187 AWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPH 246
Query: 167 LTPVTLELGGKNPCYVD-----DNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQE 221
++LELGGKNP + D C P TV + A N G+ C+ + +
Sbjct: 247 CKKLSLELGGKNPAIIFEDANLDECIPATVRSSFA-----NQGEICLCTSRIFVQKSIYS 301
Query: 222 RLLPALQSTITRFYGDDPQSSP--NLGRIINQKQFQRLR----------ALLGCG----R 265
L TR + S P ++G +I++ +++R A + CG +
Sbjct: 302 EFLKRFVEA-TRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK 360
Query: 266 VAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPL 325
+++ + +++ ++ PTV+ D+++ M EEIFGP+ +V S +E IE N + L
Sbjct: 361 LSLPAR-NQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGL 419
Query: 326 ALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 385
A +S++ V RV + SG N + +LPFGG+ +SG+GR K S+D F
Sbjct: 420 AATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRE--LNLPFGGMKSSGIGREGAKDSYDFF 477
Query: 386 S 386
+
Sbjct: 478 T 478
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 127 bits (319), Expect = 2e-29
Identities = 92/347 (26%), Positives = 161/347 (46%), Gaps = 13/347 (3%)
Query: 61 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 120
++ R EP G+ I PWN+PL + L ALA GN VV+K +E + +A ++ +
Sbjct: 169 SYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 228
Query: 121 -VDQSCFAVVLG-GPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAA-AKHLTPVTLELGG 176
+V G GP + H D + FTGS +G+++ AA + +L VTLELGG
Sbjct: 229 GFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGG 288
Query: 177 KNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFY 235
K+P + + D + + +FN GQ C A ++ + + ++ +R
Sbjct: 289 KSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVV 348
Query: 236 GDDPQSSPNLGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQE 289
G+ S G +++ QF+++ + G+ + GG + + +I PTV DVQ+
Sbjct: 349 GNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQD 408
Query: 290 MEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGF 349
+ +EEIFGP++ I+ ++++E + N LA F+ + +G
Sbjct: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
Query: 350 CGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
N + A PFGG SG GR G++ ++ + ++ P
Sbjct: 469 WVN--CYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVP 513
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 121 bits (303), Expect = 1e-27
Identities = 92/336 (27%), Positives = 155/336 (46%), Gaps = 13/336 (3%)
Query: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
+ R EP G+ I PWN+PL + + + AL+ GN VV+KP+E + +A ++ +
Sbjct: 154 YTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAG 213
Query: 121 VDQSCFAVVLG-GPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 177
+V G GP + H D + FTGS VGK++ AA K +L VTLELGGK
Sbjct: 214 FPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGK 273
Query: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGD 237
+PC V + D +++ GQ C+A + + + + ++
Sbjct: 274 SPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILG 333
Query: 238 DPQS-SPNLGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQEM 290
+P + G I+++Q+ ++ L+ G+ GG ++ PTV +V +
Sbjct: 334 NPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDE 393
Query: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
+ +EEIFGP+ I+ +SLD+ I+ N L+ F+ + + +G
Sbjct: 394 MRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVW 453
Query: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 386
N + A PFGG SG GR G++ F ++
Sbjct: 454 VN--CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYT 487
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 120 bits (302), Expect = 2e-27
Identities = 96/346 (27%), Positives = 153/346 (44%), Gaps = 13/346 (3%)
Query: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
F R EP G+ I PWN+PL + L ALA GN VV+K +E + LA ++ +
Sbjct: 170 FTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAG 229
Query: 121 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAA-KHLTPVTLELGGK 177
++ G GP + +H D + FTGS VG ++ AA +L VTLELGGK
Sbjct: 230 FPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGK 289
Query: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYG 236
+P V + D + + +FN GQ C A + L ++ R G
Sbjct: 290 SPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVG 349
Query: 237 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 290
+ + G ++++QF+R+ + G ++ GG+ E +I PTV VQ+
Sbjct: 350 NPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIKPTVFGGVQDD 409
Query: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
+ +EEIFGP+ P+ + ++E +E N LA F+ +G
Sbjct: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
Query: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
N ++ PFGG SG GR G+ ++ + ++ P
Sbjct: 470 VNT--YNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVP 513
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 119 bits (298), Expect = 5e-27
Identities = 94/337 (27%), Positives = 153/337 (45%), Gaps = 15/337 (4%)
Query: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV-LPQY 120
F +KEP G+ II PWNYPL + LAAGN +VLKP++++ AE+ +
Sbjct: 579 FTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAG 638
Query: 121 VDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGK 177
+ ++ G GQ L D + FTGS +GK +M + A +L V+LELGGK
Sbjct: 639 FPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGK 698
Query: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YG 236
+P + ++C+ +FN G+ C+A + + + + + I + G
Sbjct: 699 SPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIG 758
Query: 237 DDPQSSPNLGRIINQKQFQRLRALL------GCGRVAIGGQSDESDRYIAPTVLVDVQEM 290
D S + G ++ ++L G V G Q ++ PTV DV++
Sbjct: 759 DPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDY 818
Query: 291 EPVMQEEIFGPILPIVNVQS--LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGG 348
+ +EE FGPI+ I Q+ +D ++ N E LA F+ V + +G
Sbjct: 819 MYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGT 878
Query: 349 FCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 385
N + T + PFGGV SG G+ G+ + + +
Sbjct: 879 VFINT--YNKTDVAAPFGGVKQSGFGKDLGEEALNEY 913
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 112 bits (280), Expect = 6e-25
Identities = 91/335 (27%), Positives = 145/335 (43%), Gaps = 15/335 (4%)
Query: 64 RKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVD 122
RKEP G+ II PWNYPL + LAAGN VV+KP++++ AE+ L +
Sbjct: 560 RKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP 619
Query: 123 QSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNP 179
+ V+ G GQ L D I FTGS VGK +M + A ++ V+LELGGK+P
Sbjct: 620 KGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSP 679
Query: 180 CYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDP 239
+ +CD +FN G+ C+A + + + + + + + +P
Sbjct: 680 LIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNP 739
Query: 240 QS-------SPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEP 292
+ ++ ++ + G V G Q + PTV DV++
Sbjct: 740 LDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMF 799
Query: 293 VMQEEIFGPILPIVNVQ--SLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
+ +EE FGP++ I LD + N E LA F+ V + +G
Sbjct: 800 IAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVF 859
Query: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 385
N + T + PFGG SG G+ G+ + + +
Sbjct: 860 VNT--YNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 108 bits (271), Expect = 7e-24
Identities = 95/345 (27%), Positives = 149/345 (43%), Gaps = 59/345 (17%)
Query: 54 KATQLDSA----FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNV 109
+ TQ+D + + P G+ +I+PWN PL L + A+AAGN V+ KPSE++
Sbjct: 127 ECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVT 186
Query: 110 EKILAEVLPQY-VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAKH 166
+L ++L + V +V G GP+ L+ H I FTGS + + +A H
Sbjct: 187 AWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPH 246
Query: 167 LTPVTLELGGKNPCYVD-----DNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQE 221
++LELGGKNP + D C P TV + A + + C + +
Sbjct: 247 CKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYVKRALAEGAQIWCGEGVDK 306
Query: 222 RLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAP 281
LPA +++ ++ P
Sbjct: 307 LSLPA---------------------------------------------RNQAGYFMLP 321
Query: 282 TVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVL 341
TV+ D+++ M EEIFGP+ +V S +E IE N + LA +S++ V RV
Sbjct: 322 TVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVA 381
Query: 342 TQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 386
+ SG N + +LPFGG+ +SG+GR K S+D F+
Sbjct: 382 KKLQSGLVWTNCWLIRE--LNLPFGGMKSSGIGREGAKDSYDFFT 424
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 108 bits (270), Expect = 9e-24
Identities = 89/343 (25%), Positives = 145/343 (42%), Gaps = 45/343 (13%)
Query: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYV 121
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
Query: 122 DQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPC 180
VGK++ AA + +L VTLELGGK+P
Sbjct: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
Query: 181 YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDP 239
+ + D + +FN GQ C A + + E + +++ R G
Sbjct: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
Query: 240 QSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPV 293
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V + +
Sbjct: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
Query: 294 MQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND 353
+EEIFGP+ I+ +++DE IE N + L F+N V + +G N
Sbjct: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434
Query: 354 GFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
+ A PFGG SG GR G+F +S + ++ P
Sbjct: 435 -CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 476
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 89.4 bits (220), Expect = 6e-18
Identities = 64/265 (24%), Positives = 121/265 (45%), Gaps = 12/265 (4%)
Query: 67 PFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSC 125
P G+ IAP+N+P + L A+ GN ++KPSE +LA++L
Sbjct: 175 PLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGT 234
Query: 126 FAVVLGGPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDD 184
++ G + + +H I F GS + G+ + ++H V +G KN V
Sbjct: 235 LNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMP 294
Query: 185 NCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPN 244
+ + + N++ + AGQ C+A + E ++ L ++ Q +
Sbjct: 295 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGAD 354
Query: 245 LGRIINQKQFQRLRALLGCGR-----VAIGGQSD-----ESDRYIAPTVLVDVQEMEPVM 294
LG +I + +R+ L+ G + + G+ E+ ++ PT++ +V+
Sbjct: 355 LGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCY 414
Query: 295 QEEIFGPILPIVNVQSLDEAIEFIN 319
+EEIFGP+L ++ ++LDEAI+ +N
Sbjct: 415 KEEIFGPVLVVLETETLDEAIQIVN 439
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 72.0 bits (175), Expect = 1e-12
Identities = 98/443 (22%), Positives = 170/443 (38%), Gaps = 63/443 (14%)
Query: 6 DTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK----------- 54
+T+++ REA+ PA R ++ +G L+E Q+L ++ ++ K
Sbjct: 90 ETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQE 149
Query: 55 ---------------------ATQLDSAFIRK-EPFGLVLIIAPWNYPLNLTLVPLVGAL 92
+ + A I + P GLV II +N+P+ + A+
Sbjct: 150 YVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAM 209
Query: 93 AAGNCVVLK----PSEISKNVEKILAEVLP--QYVDQSCFAVVLGGPQETGQLLEHRFDY 146
GN + K S IS V KI+A+VL + C G T + R +
Sbjct: 210 ICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNL 269
Query: 147 IFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQT 206
+ FTGS +VGK V + LELGG N ++ D V + AGQ
Sbjct: 270 LSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQR 329
Query: 207 CVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC--- 263
C + + + ++ L+ + +P L ++ K Q + LG
Sbjct: 330 CTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTK--QAVSMFLGAVEE 387
Query: 264 -----GRVAIGGQ-SDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEF 317
G V GG+ D Y+ PT++ + + E F PIL + ++ +E +
Sbjct: 388 AKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAW 447
Query: 318 INRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND-GFMHMTLASL------PFGGVGA 370
N ++ L+ F+ + R L G G+D G +++ + + FGG
Sbjct: 448 NNEVKQGLSSSIFTKDLGRIFRWL------GPKGSDCGIVNVNIPTSGAEIGGAFGGEKH 501
Query: 371 SGMGRYHGKFSFDTFSHHRACLL 393
+G GR G ++ + C +
Sbjct: 502 TGGGRESGSDAWKQYMRRSTCTI 524
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 69 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 120
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
Query: 121 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 172
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
Query: 173 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 232
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
Query: 233 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 283
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
Query: 284 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 340
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493
Query: 341 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 372
+ + ++G F ND + PFGG ASG
Sbjct: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 69 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 120
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 142 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 197
Query: 121 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 172
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 198 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 253
Query: 173 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 232
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 254 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 313
Query: 233 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 283
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 314 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 373
Query: 284 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 340
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 374 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 433
Query: 341 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 372
+ + ++G F ND + PFGG ASG
Sbjct: 434 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 467
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 69 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 120
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 202 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 257
Query: 121 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 172
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 258 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 313
Query: 173 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 232
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 314 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 373
Query: 233 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 283
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 374 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 433
Query: 284 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 340
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 434 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 493
Query: 341 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 372
+ + ++G F ND + PFGG ASG
Sbjct: 494 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 527
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 37.0 bits (84), Expect = 0.035
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 2/113 (1%)
Query: 65 KEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQS 124
+EP G++ ++ P +PL + L ALA GN VV+ PS + + + +
Sbjct: 607 REPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAG 666
Query: 125 CFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELG 175
VV G + L D +++ GS + + V A+A +L PV G
Sbjct: 667 LANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 719
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,742,347
Number of Sequences: 37866
Number of extensions: 750805
Number of successful extensions: 1621
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1519
Number of HSP's gapped (non-prelim): 47
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.