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Search of human proteins with 71565160
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2
[Homo sapiens]
(1235 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 2411 0.0
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 1343 0.0
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 327 4e-89
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 327 4e-89
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 201 3e-51
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 201 3e-51
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 201 3e-51
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 192 2e-48
gi|71061468 centromere protein E [Homo sapiens] 124 7e-28
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 114 7e-25
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 113 1e-24
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 111 4e-24
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 109 2e-23
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 106 1e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 105 3e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 105 3e-22
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 105 3e-22
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 105 3e-22
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 102 3e-21
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 101 4e-21
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 101 4e-21
gi|118498368 kinectin 1 isoform c [Homo sapiens] 97 7e-20
gi|221219020 NYD-SP11 protein [Homo sapiens] 97 9e-20
gi|118498356 kinectin 1 isoform a [Homo sapiens] 97 9e-20
gi|33620775 kinectin 1 isoform a [Homo sapiens] 97 9e-20
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 96 2e-19
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 96 2e-19
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 95 5e-19
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 94 8e-19
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 94 8e-19
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 [Homo
sapiens]
Length = 1235
Score = 2411 bits (6249), Expect = 0.0
Identities = 1235/1235 (100%), Positives = 1235/1235 (100%)
Query: 1 MAHLELLLVENFKSWRGRQVIGPFRRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKN 60
MAHLELLLVENFKSWRGRQVIGPFRRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKN
Sbjct: 1 MAHLELLLVENFKSWRGRQVIGPFRRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKN 60
Query: 61 IQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE 120
IQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE
Sbjct: 61 IQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE 120
Query: 121 LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEE 180
LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEE
Sbjct: 121 LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEE 180
Query: 181 DAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNT 240
DAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNT
Sbjct: 181 DAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNT 240
Query: 241 KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIK 300
KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIK
Sbjct: 241 KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIK 300
Query: 301 AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILH 360
AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILH
Sbjct: 301 AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILH 360
Query: 361 KKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGN 420
KKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGN
Sbjct: 361 KKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGN 420
Query: 421 LKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLI 480
LKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLI
Sbjct: 421 LKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLI 480
Query: 481 RSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGR 540
RSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGR
Sbjct: 481 RSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGR 540
Query: 541 FITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKT 600
FITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKT
Sbjct: 541 FITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKT 600
Query: 601 QFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLK 660
QFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLK
Sbjct: 601 QFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLK 660
Query: 661 YKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELE 720
YKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELE
Sbjct: 661 YKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELE 720
Query: 721 MIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHF 780
MIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHF
Sbjct: 721 MIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHF 780
Query: 781 CEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKE 840
CEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKE
Sbjct: 781 CEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKE 840
Query: 841 TIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLA 900
TIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLA
Sbjct: 841 TIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLA 900
Query: 901 VDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAE 960
VDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAE
Sbjct: 901 VDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAE 960
Query: 961 STQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPN 1020
STQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPN
Sbjct: 961 STQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPN 1020
Query: 1021 LRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQI 1080
LRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQI
Sbjct: 1021 LRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQI 1080
Query: 1081 YKKLCRNNSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAV 1140
YKKLCRNNSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAV
Sbjct: 1081 YKKLCRNNSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAV 1140
Query: 1141 HSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADALIGIY 1200
HSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADALIGIY
Sbjct: 1141 HSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADALIGIY 1200
Query: 1201 PEYDDCMFSRVLTLDLSQYPDTEGQESSKRHGESR 1235
PEYDDCMFSRVLTLDLSQYPDTEGQESSKRHGESR
Sbjct: 1201 PEYDDCMFSRVLTLDLSQYPDTEGQESSKRHGESR 1235
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 1343 bits (3476), Expect = 0.0
Identities = 658/1225 (53%), Positives = 919/1225 (75%), Gaps = 4/1225 (0%)
Query: 1 MAHLELLLVENFKSWRGRQVIGPFRRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKN 60
M L+L+ +ENFKS++GRQ+IGPF+RFT IIGPNGSGKSN+MDA+SFV+GEK +NLRVK
Sbjct: 1 MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKT 60
Query: 61 IQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE 120
+++LIHGA +GKP ++ A V ++Y EE E++TFAR+I GG SE++ N+ +V Y E
Sbjct: 61 LRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEE 120
Query: 121 LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEE 180
LEK+GI++KA+N LVFQG VESI++K PKERT FEEIS SGEL EY+++K+++ KAEE
Sbjct: 121 LEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEE 180
Query: 181 DAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNT 240
D QFN+++KKNIAAER++AK EKEEA+RYQ L +E+ ++QLQLF+LYHNE +I LN
Sbjct: 181 DTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNK 240
Query: 241 KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIK 300
+L N+++ ++ + E+ +K +KKE G + R+ QQ EKE+K ++ LNQKRPQYIK
Sbjct: 241 ELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIK 300
Query: 301 AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILH 360
AKENTSH +KKL+ AKKS+++++K K++ D+ LE E+ ++ A + FE+++EEE
Sbjct: 301 AKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS 360
Query: 361 KKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGN 420
+ RD+ LE +Q+ +Y LKE+ K+ AT+ Q+LEK +QK D++RL E+R+ E +
Sbjct: 361 QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAK 420
Query: 421 LKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLI 480
+KQ +IE+++KRIEKLEEY T L+E+K+ E L +E+E K R+ E N+ELN +
Sbjct: 421 IKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV 480
Query: 481 RSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGR 540
+L +A ID E RQQ++AE++E +KRLYP SV+GRL DLC P KKYQ+AVTKV G+
Sbjct: 481 MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK 540
Query: 541 FITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKT 600
+ AI+V SEK +DCI+++KE+R EPETFL LDYL++KP +E+LRELKG K+VIDVI+
Sbjct: 541 NMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRY 600
Query: 601 QFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLK 660
+ P +KK +Q+ CGN LVC+ +E+AR IA G +R KTVALDGTLF KSGVISGG+SDLK
Sbjct: 601 EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK 660
Query: 661 YKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELE 720
KAR WDEK + L++++ + +ELK MK RKE +L+Q+Q+ G Q RLKYSQ++LE
Sbjct: 661 AKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE 720
Query: 721 MIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHF 780
K +HL QE+S+L+SEL N + + I+ R+R +K+ +EK+++VED++F+ F
Sbjct: 721 QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF 780
Query: 781 CEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKE 840
C EIGV NIREFE + VKRQ EI +KRLEFE QKTRL +QL++ ++ LK+ +K++ ++
Sbjct: 781 CREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQ 840
Query: 841 TIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLA 900
T++K +I+ LKK E+ ++ ++E MA+ Q LK+ + + S ++EE RKK
Sbjct: 841 TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG 900
Query: 901 VDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAE 960
++E+ LQKEV +I+T LEQKR ++HNLL CK+QDI++ L G++DDI + E ++ E
Sbjct: 901 ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE 960
Query: 961 ----STQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKT 1016
+Q IY +E EIDY L EDLK Q+++EI+ + L Q++ Q+ +L +
Sbjct: 961 DSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRI 1020
Query: 1017 AAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSIS 1076
AAPN++A+E L++VRDKFQE++D FEA+RK A+ +Q FEQ+KK R+D F CFE V+ +
Sbjct: 1021 AAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATN 1080
Query: 1077 IDQIYKKLCRNNSAQAFLSPENPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALAL 1136
ID+IYK L RN+SAQAFL PENPEEPYL+GI+YNCVAPGKRF PMDNLSGGEK VAALAL
Sbjct: 1081 IDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALAL 1140
Query: 1137 LFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADAL 1196
LFA+HS++PAPFFVLDE+DAALDNTNIGKV++YIKEQ+ FQ IVISLKEEFY++A++L
Sbjct: 1141 LFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESL 1200
Query: 1197 IGIYPEYDDCMFSRVLTLDLSQYPD 1221
IG+YPE DC+ S+VLT DL++YPD
Sbjct: 1201 IGVYPEQGDCVISKVLTFDLTKYPD 1225
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 327 bits (838), Expect = 4e-89
Identities = 302/1247 (24%), Positives = 574/1247 (46%), Gaps = 118/1247 (9%)
Query: 10 ENFKSWRGRQVIGPF-RRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKNIQELIHGA 68
+NFKS+ G +++GPF +RF+CIIGPNGSGKSNV+D++ FV G + +R K + LIH +
Sbjct: 90 QNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNS 149
Query: 69 HIGKPISSSASVKIIY---VEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE----- 120
K I S +V++ + +++ G++ S DN SVY
Sbjct: 150 DEHKDIQS-CTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNT---SVYHISGKKKT 205
Query: 121 -------LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQ-------FFEEISTSGELIG 166
L GI + L+ QG VE I++ KPK +T+ + E+I G L
Sbjct: 206 FKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNE 265
Query: 167 EYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLF 226
+ R+++ E N+ K + E+ + EK A + +L E+ K + +
Sbjct: 266 PIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQY 325
Query: 227 QLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKS 286
+Y +K+I + T+ E ++ D E + N +KA+ K+ ++ TEK+L
Sbjct: 326 YIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKD-------VKDTEKKLNK 378
Query: 287 VETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELA----- 341
+ + + + ++ + +KL A K EKQ K ++ ++ ++ A
Sbjct: 379 ITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNI 438
Query: 342 --DLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWE 399
+ + EK+ E+E K ++ + ++ KE K++ ++ + + + +
Sbjct: 439 INETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSK 498
Query: 400 QKTDEERLAFEKRRHGEVQGNLKQIKEQI-------EDHKKRIEKLEEYTKTCMDCLKEK 452
+ L RH L + KE + ++ K I +E LKEK
Sbjct: 499 MDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEK 558
Query: 453 KQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYP 512
+++ + L E KS + + +++ +S L ++ GK +++ K
Sbjct: 559 EKELQKLTQEETNFKSLVHDLFQKVEEAKSSL---AMNRSRGKVLDA---IIQEKKSGRI 612
Query: 513 DSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLA 572
++GRL DL I +KY +A++ + IVV S +A++C+ FLK + TF+
Sbjct: 613 PGIYGRLGDL-GAIDEKYDVAISSCC-HALDYIVVDSIDIAQECVNFLKRQNIGVATFIG 670
Query: 573 LDYLDI--KPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIAL 630
LD + + K + E ++ + + D++K + ++++ F + LV + +++A +A
Sbjct: 671 LDKMAVWAKKMTE-IQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAY 729
Query: 631 SGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMK 690
R + V L G + +SG ++GG S + K R ++ + ++ +L+ K
Sbjct: 730 QKDRRWRVVTLQGQIIEQSGTMTGGGSKVM-KGRMGSSLVIEISEEEVNKMESQLQNDSK 788
Query: 691 TLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNI---ESQ 747
K +++ + ++ +L++S+ E+ +K + ++ Q E LN+ E +
Sbjct: 789 ---KAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASI--QRLIEQEEYLNVQVKELE 843
Query: 748 CIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKR 807
+L+ ++++++ E K E D ++ E ++ N V EI+ +
Sbjct: 844 ANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAE-VKRLHNTIV----EINNHK 898
Query: 808 LEFEKQKT-RLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNEL 866
L+ ++ K ++N QL+ S + K I T +QK + + +K ++ + V++L
Sbjct: 899 LKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDL 958
Query: 867 MAKQQQLKDIR---VTQNSSAEKVQTQIEEERKKFL----AVDREVGKLQKEVVSIQTSL 919
A+ + L+D V ++AE+ +I++E + L + LQK+ +SI+ L
Sbjct: 959 TAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKL 1018
Query: 920 EQ--KRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEI 977
EQ + +HN + ++I I L D+ IE EI
Sbjct: 1019 EQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIE-----------------------EI 1055
Query: 978 DYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQES 1037
S EDL+A+++ I + LL + + PNL A+ K + + +
Sbjct: 1056 SVLS-PEDLEAIKNPDSITNQIALLEARCHEMK--------PNLGAIAEYKKKEELYLQR 1106
Query: 1038 TDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLSPE 1097
+ E RQ +E ++K+R + F F ++ + + Y+ L A+ L
Sbjct: 1107 VAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAE--LELV 1164
Query: 1098 NPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAA 1157
+ +P+ EGI ++ P K + + NLSGGEK +++LAL+FA+H ++P P + +DE+DAA
Sbjct: 1165 DSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAA 1224
Query: 1158 LDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADALIGIYPEYD 1204
LD N+ V+ YI EQT++ Q I+ISL+ + +D LIGIY Y+
Sbjct: 1225 LDFKNVSIVAFYIYEQTKNA-QFIIISLRNNMFEISDRLIGIYKTYN 1270
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 327 bits (838), Expect = 4e-89
Identities = 302/1247 (24%), Positives = 574/1247 (46%), Gaps = 118/1247 (9%)
Query: 10 ENFKSWRGRQVIGPF-RRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKNIQELIHGA 68
+NFKS+ G +++GPF +RF+CIIGPNGSGKSNV+D++ FV G + +R K + LIH +
Sbjct: 90 QNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNS 149
Query: 69 HIGKPISSSASVKIIY---VEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE----- 120
K I S +V++ + +++ G++ S DN SVY
Sbjct: 150 DEHKDIQS-CTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNT---SVYHISGKKKT 205
Query: 121 -------LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQ-------FFEEISTSGELIG 166
L GI + L+ QG VE I++ KPK +T+ + E+I G L
Sbjct: 206 FKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNE 265
Query: 167 EYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLF 226
+ R+++ E N+ K + E+ + EK A + +L E+ K + +
Sbjct: 266 PIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQY 325
Query: 227 QLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKS 286
+Y +K+I + T+ E ++ D E + N +KA+ K+ ++ TEK+L
Sbjct: 326 YIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKD-------VKDTEKKLNK 378
Query: 287 VETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELA----- 341
+ + + + ++ + +KL A K EKQ K ++ ++ ++ A
Sbjct: 379 ITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNI 438
Query: 342 --DLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWE 399
+ + EK+ E+E K ++ + ++ KE K++ ++ + + + +
Sbjct: 439 INETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSK 498
Query: 400 QKTDEERLAFEKRRHGEVQGNLKQIKEQI-------EDHKKRIEKLEEYTKTCMDCLKEK 452
+ L RH L + KE + ++ K I +E LKEK
Sbjct: 499 MDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEK 558
Query: 453 KQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYP 512
+++ + L E KS + + +++ +S L ++ GK +++ K
Sbjct: 559 EKELQKLTQEETNFKSLVHDLFQKVEEAKSSL---AMNRSRGKVLDA---IIQEKKSGRI 612
Query: 513 DSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLA 572
++GRL DL I +KY +A++ + IVV S +A++C+ FLK + TF+
Sbjct: 613 PGIYGRLGDL-GAIDEKYDVAISSCC-HALDYIVVDSIDIAQECVNFLKRQNIGVATFIG 670
Query: 573 LDYLDI--KPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIAL 630
LD + + K + E ++ + + D++K + ++++ F + LV + +++A +A
Sbjct: 671 LDKMAVWAKKMTE-IQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAY 729
Query: 631 SGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMK 690
R + V L G + +SG ++GG S + K R ++ + ++ +L+ K
Sbjct: 730 QKDRRWRVVTLQGQIIEQSGTMTGGGSKVM-KGRMGSSLVIEISEEEVNKMESQLQNDSK 788
Query: 691 TLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNI---ESQ 747
K +++ + ++ +L++S+ E+ +K + ++ Q E LN+ E +
Sbjct: 789 ---KAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASI--QRLIEQEEYLNVQVKELE 843
Query: 748 CIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKR 807
+L+ ++++++ E K E D ++ E ++ N V EI+ +
Sbjct: 844 ANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAE-VKRLHNTIV----EINNHK 898
Query: 808 LEFEKQKT-RLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNEL 866
L+ ++ K ++N QL+ S + K I T +QK + + +K ++ + V++L
Sbjct: 899 LKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDL 958
Query: 867 MAKQQQLKDIR---VTQNSSAEKVQTQIEEERKKFL----AVDREVGKLQKEVVSIQTSL 919
A+ + L+D V ++AE+ +I++E + L + LQK+ +SI+ L
Sbjct: 959 TAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKL 1018
Query: 920 EQ--KRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEI 977
EQ + +HN + ++I I L D+ IE EI
Sbjct: 1019 EQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIE-----------------------EI 1055
Query: 978 DYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQES 1037
S EDL+A+++ I + LL + + PNL A+ K + + +
Sbjct: 1056 SVLS-PEDLEAIKNPDSITNQIALLEARCHEMK--------PNLGAIAEYKKKEELYLQR 1106
Query: 1038 TDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLSPE 1097
+ E RQ +E ++K+R + F F ++ + + Y+ L A+ L
Sbjct: 1107 VAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAE--LELV 1164
Query: 1098 NPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAA 1157
+ +P+ EGI ++ P K + + NLSGGEK +++LAL+FA+H ++P P + +DE+DAA
Sbjct: 1165 DSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAA 1224
Query: 1158 LDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADALIGIYPEYD 1204
LD N+ V+ YI EQT++ Q I+ISL+ + +D LIGIY Y+
Sbjct: 1225 LDFKNVSIVAFYIYEQTKNA-QFIIISLRNNMFEISDRLIGIYKTYN 1270
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 201 bits (512), Expect = 3e-51
Identities = 281/1267 (22%), Positives = 526/1267 (41%), Gaps = 185/1267 (14%)
Query: 3 HLELLLVENFKSWRGRQVIGPFRR-FTCIIGPNGSGKSNVMDALSFVMG-EKIANLRVKN 60
H++ +++E FKS+ R + F F I G NGSGKSN++D++ F++G ++ +R N
Sbjct: 2 HIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASN 61
Query: 61 IQELIHGAHIGKPISSSASVKIIYVE----------ESGEEKTFAR-IIRGGCSEFRFND 109
+Q+L++ G+ + ASV I + E +E T R ++ GG +++ N
Sbjct: 62 LQDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLING 119
Query: 110 NLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYE 169
+ + +G+ V + L+ QG + + KP E EE + + YE
Sbjct: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRM----YE 175
Query: 170 EKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAER-----YQSLLEELK-MNKIQL 223
KK QK E + + K I E ++K + ER YQ ++ E++ ++++ +
Sbjct: 176 YKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI 235
Query: 224 QLFQLYHNEKKIHLLNTKLEHVNRDLSVKRE---------SLSHH-ENIVKARKKEHGML 273
L + K+ E ++ + ++ E +L+H E + K + KE G +
Sbjct: 236 AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
Query: 274 TRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDS------EKQCS 327
R L+ E + V T + +K K K+ ++ K ++DS EK+
Sbjct: 296 LRSLEDALAEAQRVNT--KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
Query: 328 KQEDDIKALETELADLDAAWRSFEKQIEEEI---LHKKRDIELEASQLDRYKELKEQVRK 384
K D + AL+ E ++ DA + +Q + L D EA+ + K + K
Sbjct: 354 KITDGLHALQ-EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEATLAGQMMACKNDISK 411
Query: 385 KVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKT 444
Q KL+ Q+ + + A K+ + ++ +E +E K+ EKLE K
Sbjct: 412 AQTEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKK 467
Query: 445 CMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVL 504
L ++ +EE+L+++ + + E + + N + ++ R
Sbjct: 468 ----LNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR---- 519
Query: 505 EHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEER 564
+ V G + L A+ V G + +VV +E K + + E
Sbjct: 520 --------NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLE--RGEL 569
Query: 565 AEPETFLALDYLDIKPIN-ERLRELKGC------KMVIDVIKTQFPQLKKVIQFVCGNGL 617
T + L+ + + I E LR + + + +++ + P+L+K ++FV G
Sbjct: 570 KRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK-PELQKAMEFVFGTTF 628
Query: 618 VCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDR 677
VC+ M+ A+ +A +TV L G +F G +SGG+ + + +ELK+++D
Sbjct: 629 VCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARS-QAASILTKFQELKDVQDE 687
Query: 678 RSQKIQELK-------GLMKTLRKETDLKQ-----------IQTLIQGTQTRLKYSQNEL 719
K EL+ GL T K LKQ +QT +Q Q+ Q EL
Sbjct: 688 LRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHKQQEEL 745
Query: 720 EMIKKKHLVAFYQEQSQLQSELLN-IESQCIMLSEGIK----ERQRRIKEFQEKIDKVED 774
+ +KK + +E + E+ E + +L +K ER+R +K+ Q+K+D
Sbjct: 746 DALKKT--IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLD---- 799
Query: 775 DIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQK---TRLNVQLEYSRSHLKKK 831
C + + K ++QQE++ LE E+ K T QLE +K
Sbjct: 800 ------CAKTKAD---ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSY 850
Query: 832 LNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQI 891
++I + + K E ++ KA+E + + A+ +K + + K + Q
Sbjct: 851 ESQIEVMAAEVAKNKESVN---KAQEEVTKQKEVITAQDTVIK----AKYAEVAKHKEQN 903
Query: 892 EEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951
+ + K +D + K ++E E + +L D + E L
Sbjct: 904 NDSQLKIKELDHNISKHKREA-------EDGAAKVSKMLKDYDWINAERHLFG------- 949
Query: 952 EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
+ A++ ++ KE + LQ QE++ L +
Sbjct: 950 ------------------QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV-------- 983
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
N+RA+ L +++ + + E + +++ ++
Sbjct: 984 --------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ 1035
Query: 1072 HVSISIDQIYKKLCRNNSAQAFLSPENPE-EPYLEGISYNCVAPGKRFMPMDNLSGGEKC 1130
V+ I+ L A A L+P PE + L+G+ + + LSGG++
Sbjct: 1036 KVNKDFGSIFSTLLPG--ANAMLAP--PEGQTVLDGLEFKVALGNTWKENLTELSGGQRS 1091
Query: 1131 VAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQ-TQDQFQMIVISLKEEF 1189
+ AL+L+ ++ F+PAP ++LDEVDAALD ++ + ++ T QF IV+SLKE
Sbjct: 1092 LVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF--IVVSLKEGM 1149
Query: 1190 YSRADAL 1196
++ A+ L
Sbjct: 1150 FNNANVL 1156
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 201 bits (512), Expect = 3e-51
Identities = 281/1267 (22%), Positives = 526/1267 (41%), Gaps = 185/1267 (14%)
Query: 3 HLELLLVENFKSWRGRQVIGPFRR-FTCIIGPNGSGKSNVMDALSFVMG-EKIANLRVKN 60
H++ +++E FKS+ R + F F I G NGSGKSN++D++ F++G ++ +R N
Sbjct: 2 HIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASN 61
Query: 61 IQELIHGAHIGKPISSSASVKIIYVE----------ESGEEKTFAR-IIRGGCSEFRFND 109
+Q+L++ G+ + ASV I + E +E T R ++ GG +++ N
Sbjct: 62 LQDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLING 119
Query: 110 NLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYE 169
+ + +G+ V + L+ QG + + KP E EE + + YE
Sbjct: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRM----YE 175
Query: 170 EKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAER-----YQSLLEELK-MNKIQL 223
KK QK E + + K I E ++K + ER YQ ++ E++ ++++ +
Sbjct: 176 YKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI 235
Query: 224 QLFQLYHNEKKIHLLNTKLEHVNRDLSVKRE---------SLSHH-ENIVKARKKEHGML 273
L + K+ E ++ + ++ E +L+H E + K + KE G +
Sbjct: 236 AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
Query: 274 TRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDS------EKQCS 327
R L+ E + V T + +K K K+ ++ K ++DS EK+
Sbjct: 296 LRSLEDALAEAQRVNT--KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
Query: 328 KQEDDIKALETELADLDAAWRSFEKQIEEEI---LHKKRDIELEASQLDRYKELKEQVRK 384
K D + AL+ E ++ DA + +Q + L D EA+ + K + K
Sbjct: 354 KITDGLHALQ-EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEATLAGQMMACKNDISK 411
Query: 385 KVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKT 444
Q KL+ Q+ + + A K+ + ++ +E +E K+ EKLE K
Sbjct: 412 AQTEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKK 467
Query: 445 CMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVL 504
L ++ +EE+L+++ + + E + + N + ++ R
Sbjct: 468 ----LNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR---- 519
Query: 505 EHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEER 564
+ V G + L A+ V G + +VV +E K + + E
Sbjct: 520 --------NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLE--RGEL 569
Query: 565 AEPETFLALDYLDIKPIN-ERLRELKGC------KMVIDVIKTQFPQLKKVIQFVCGNGL 617
T + L+ + + I E LR + + + +++ + P+L+K ++FV G
Sbjct: 570 KRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK-PELQKAMEFVFGTTF 628
Query: 618 VCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDR 677
VC+ M+ A+ +A +TV L G +F G +SGG+ + + +ELK+++D
Sbjct: 629 VCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARS-QAASILTKFQELKDVQDE 687
Query: 678 RSQKIQELK-------GLMKTLRKETDLKQ-----------IQTLIQGTQTRLKYSQNEL 719
K EL+ GL T K LKQ +QT +Q Q+ Q EL
Sbjct: 688 LRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHKQQEEL 745
Query: 720 EMIKKKHLVAFYQEQSQLQSELLN-IESQCIMLSEGIK----ERQRRIKEFQEKIDKVED 774
+ +KK + +E + E+ E + +L +K ER+R +K+ Q+K+D
Sbjct: 746 DALKKT--IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLD---- 799
Query: 775 DIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQK---TRLNVQLEYSRSHLKKK 831
C + + K ++QQE++ LE E+ K T QLE +K
Sbjct: 800 ------CAKTKAD---ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSY 850
Query: 832 LNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQI 891
++I + + K E ++ KA+E + + A+ +K + + K + Q
Sbjct: 851 ESQIEVMAAEVAKNKESVN---KAQEEVTKQKEVITAQDTVIK----AKYAEVAKHKEQN 903
Query: 892 EEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951
+ + K +D + K ++E E + +L D + E L
Sbjct: 904 NDSQLKIKELDHNISKHKREA-------EDGAAKVSKMLKDYDWINAERHLFG------- 949
Query: 952 EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
+ A++ ++ KE + LQ QE++ L +
Sbjct: 950 ------------------QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV-------- 983
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
N+RA+ L +++ + + E + +++ ++
Sbjct: 984 --------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ 1035
Query: 1072 HVSISIDQIYKKLCRNNSAQAFLSPENPE-EPYLEGISYNCVAPGKRFMPMDNLSGGEKC 1130
V+ I+ L A A L+P PE + L+G+ + + LSGG++
Sbjct: 1036 KVNKDFGSIFSTLLPG--ANAMLAP--PEGQTVLDGLEFKVALGNTWKENLTELSGGQRS 1091
Query: 1131 VAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQ-TQDQFQMIVISLKEEF 1189
+ AL+L+ ++ F+PAP ++LDEVDAALD ++ + ++ T QF IV+SLKE
Sbjct: 1092 LVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF--IVVSLKEGM 1149
Query: 1190 YSRADAL 1196
++ A+ L
Sbjct: 1150 FNNANVL 1156
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 201 bits (512), Expect = 3e-51
Identities = 281/1267 (22%), Positives = 526/1267 (41%), Gaps = 185/1267 (14%)
Query: 3 HLELLLVENFKSWRGRQVIGPFRR-FTCIIGPNGSGKSNVMDALSFVMG-EKIANLRVKN 60
H++ +++E FKS+ R + F F I G NGSGKSN++D++ F++G ++ +R N
Sbjct: 2 HIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASN 61
Query: 61 IQELIHGAHIGKPISSSASVKIIYVE----------ESGEEKTFAR-IIRGGCSEFRFND 109
+Q+L++ G+ + ASV I + E +E T R ++ GG +++ N
Sbjct: 62 LQDLVYKN--GQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLING 119
Query: 110 NLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYE 169
+ + +G+ V + L+ QG + + KP E EE + + YE
Sbjct: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRM----YE 175
Query: 170 EKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAER-----YQSLLEELK-MNKIQL 223
KK QK E + + K I E ++K + ER YQ ++ E++ ++++ +
Sbjct: 176 YKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYI 235
Query: 224 QLFQLYHNEKKIHLLNTKLEHVNRDLSVKRE---------SLSHH-ENIVKARKKEHGML 273
L + K+ E ++ + ++ E +L+H E + K + KE G +
Sbjct: 236 AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGI 295
Query: 274 TRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDS------EKQCS 327
R L+ E + V T + +K K K+ ++ K ++DS EK+
Sbjct: 296 LRSLEDALAEAQRVNT--KSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVK 353
Query: 328 KQEDDIKALETELADLDAAWRSFEKQIEEEI---LHKKRDIELEASQLDRYKELKEQVRK 384
K D + AL+ E ++ DA + +Q + L D EA+ + K + K
Sbjct: 354 KITDGLHALQ-EASNKDAEALAAAQQHFNAVSAGLSSNED-GAEATLAGQMMACKNDISK 411
Query: 385 KVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKT 444
Q KL+ Q+ + + A K+ + ++ +E +E K+ EKLE K
Sbjct: 412 AQTEAKQAQMKLKHAQQELKNKQAEVKK----MDSGYRKDQEALEAVKRLKEKLEAEMKK 467
Query: 445 CMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVL 504
L ++ +EE+L+++ + + E + + N + ++ R
Sbjct: 468 ----LNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNR---- 519
Query: 505 EHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEER 564
+ V G + L A+ V G + +VV +E K + + E
Sbjct: 520 --------NCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLE--RGEL 569
Query: 565 AEPETFLALDYLDIKPIN-ERLRELKGC------KMVIDVIKTQFPQLKKVIQFVCGNGL 617
T + L+ + + I E LR + + + +++ + P+L+K ++FV G
Sbjct: 570 KRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYK-PELQKAMEFVFGTTF 628
Query: 618 VCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDR 677
VC+ M+ A+ +A +TV L G +F G +SGG+ + + +ELK+++D
Sbjct: 629 VCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARS-QAASILTKFQELKDVQDE 687
Query: 678 RSQKIQELK-------GLMKTLRKETDLKQ-----------IQTLIQGTQTRLKYSQNEL 719
K EL+ GL T K LKQ +QT +Q Q+ Q EL
Sbjct: 688 LRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQ--QSSYHKQQEEL 745
Query: 720 EMIKKKHLVAFYQEQSQLQSELLN-IESQCIMLSEGIK----ERQRRIKEFQEKIDKVED 774
+ +KK + +E + E+ E + +L +K ER+R +K+ Q+K+D
Sbjct: 746 DALKKT--IEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLD---- 799
Query: 775 DIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQK---TRLNVQLEYSRSHLKKK 831
C + + K ++QQE++ LE E+ K T QLE +K
Sbjct: 800 ------CAKTKAD---ASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSY 850
Query: 832 LNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQI 891
++I + + K E ++ KA+E + + A+ +K + + K + Q
Sbjct: 851 ESQIEVMAAEVAKNKESVN---KAQEEVTKQKEVITAQDTVIK----AKYAEVAKHKEQN 903
Query: 892 EEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951
+ + K +D + K ++E E + +L D + E L
Sbjct: 904 NDSQLKIKELDHNISKHKREA-------EDGAAKVSKMLKDYDWINAERHLFG------- 949
Query: 952 EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
+ A++ ++ KE + LQ QE++ L +
Sbjct: 950 ------------------QPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNV-------- 983
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
N+RA+ L +++ + + E + +++ ++
Sbjct: 984 --------NMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQ 1035
Query: 1072 HVSISIDQIYKKLCRNNSAQAFLSPENPE-EPYLEGISYNCVAPGKRFMPMDNLSGGEKC 1130
V+ I+ L A A L+P PE + L+G+ + + LSGG++
Sbjct: 1036 KVNKDFGSIFSTLLPG--ANAMLAP--PEGQTVLDGLEFKVALGNTWKENLTELSGGQRS 1091
Query: 1131 VAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIKEQ-TQDQFQMIVISLKEEF 1189
+ AL+L+ ++ F+PAP ++LDEVDAALD ++ + ++ T QF IV+SLKE
Sbjct: 1092 LVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQF--IVVSLKEGM 1149
Query: 1190 YSRADAL 1196
++ A+ L
Sbjct: 1150 FNNANVL 1156
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 192 bits (488), Expect = 2e-48
Identities = 278/1288 (21%), Positives = 534/1288 (41%), Gaps = 191/1288 (14%)
Query: 3 HLELLLVENFKSWRGRQVIGPFR-RFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKNI 61
+++ ++++ F+S+R + ++ PF + I+G NGSGKSN A+ FV+ ++ ++LR +
Sbjct: 2 YIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQR 61
Query: 62 QELIHGAHIGKPISSSASVKIIYVEESG------EEKTFARIIRGGCSEFRFNDNLVSRS 115
L+H + IS A V+II+ EE + R+I ++ + +V+++
Sbjct: 62 LALLHEGTGPRVIS--AFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKN 119
Query: 116 VYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKL 175
+ LE G +V QG + ++ +R + E++ + + E +E+ L
Sbjct: 120 DVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGT-RVYDERKEESISL 178
Query: 176 QKAEEDAQFNFNKKKNIAAERRQA-KLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKK 234
K E + N+ ER + EKEE +YQ K +K++ L +N++
Sbjct: 179 MKETEGKREKINELLKYIEERLHTLEEEKEELAQYQ------KWDKMRRALEYTIYNQE- 231
Query: 235 IHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQK 294
++ KL+ +LS KRE+ ++ +++ +++ +ELK+ + + ++
Sbjct: 232 LNETRAKLD----ELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEE 287
Query: 295 RPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQI 354
+ Q ++ KL++ K ++D S+Q K L E +++
Sbjct: 288 KEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQR---KRLLKE-----------RQKL 333
Query: 355 EEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRH 414
E+I K++++ + + KE +E+ ++A TQ+ L +Q + + E+R
Sbjct: 334 LEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDK 393
Query: 415 GEVQGNLKQIKEQIEDHKKRI---------------EKLEEYTKTCMDCLKEKKQQEETL 459
++ LK + + I D K++I + LE+Y K D L E K + E L
Sbjct: 394 W-IKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQD-LNEVKARVEEL 451
Query: 460 VDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQ--------------------- 498
+ + K++ E E N + E +NA KR+
Sbjct: 452 DRKYYEVKNKKDELQSERNYLWRE-ENAEQQALAAKREDLEKKQQLLRAATGKAILNGID 510
Query: 499 ---------KRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVAS 549
+R + +H++ Y V C P Y R IV +
Sbjct: 511 SINKVLDHFRRKGINQHVQNGYHGIVMNNFE--CEPAF--YTCVEVTAGNRLFYHIVDSD 566
Query: 550 EKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVI 609
E K + F K TFL L+ LD++ + E +I ++ P+ K
Sbjct: 567 EVSTKILMEFNKMNLPGEVTFLPLNKLDVR--DTAYPETNDAIPMISKLRYN-PRFDKAF 623
Query: 610 QFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEK 669
+ V G L+C +ME + +A + + L+G G ++GG D + K+R +K
Sbjct: 624 KHVFGKTLICRSMEVSTQLARA--FTMDCITLEGDQVSHRGALTGGYYDTR-KSRLELQK 680
Query: 670 ELKNLRDRRSQ---KIQE-LKGLMKTLRKETD--LKQIQTLIQGTQTRLKYSQ----NEL 719
+++ + + K+ E L+ ++ + E D + Q+Q I+ Q + K S+ +E+
Sbjct: 681 DVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQ-IETQQRKFKASRDSILSEM 739
Query: 720 EMIKKKHLVA---FYQEQSQLQS------------ELLNIESQCIMLSEGIKERQRRIKE 764
+M+K+K + F +Q LQS E L E +LS+ E Q+R+
Sbjct: 740 KMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDA 799
Query: 765 FQEKIDKVEDDIFQHFCEEIGVENI----REFENKHV-KRQQEIDQKRLEFEKQK----- 814
++I +++ + Q E I +E I + N+++ KR +++Q+ E + +
Sbjct: 800 LNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVL 859
Query: 815 TRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELM-AKQQQL 873
T +LE +K + + L +I K I L+K+ E E M A
Sbjct: 860 TATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDT 919
Query: 874 KDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDC 933
K++ N Q + +++++ + RE+G L +E +L K+L + +
Sbjct: 920 KELEKMTNR-----QGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNT 974
Query: 934 KVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQ 993
+++ + +LD + E + +++E + Y S+ E + L+ +
Sbjct: 975 ELKKYSHV-NKKALDQFVNFSEQKE--------KLIKRQEELDRGYKSIMELMNVLEL-R 1024
Query: 994 EIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQ 1053
+ EA ++L +QV+ + + P +A +K + +S D E S +
Sbjct: 1025 KYEA-IQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESE----- 1078
Query: 1054 EFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLSPENPEEPYLEGISYNCVA 1113
R + +Q+ + P G+
Sbjct: 1079 --------------------------------RGSGSQSSV----PSVDQFTGVGIRVSF 1102
Query: 1114 PGKR--FMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAALDNTNIGKVSSYIK 1171
GK+ M LSGG+K + ALAL+FA+ PAPF++ DE+D ALD + VS I
Sbjct: 1103 TGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIM 1162
Query: 1172 EQTQDQFQMIVISLKEEFYSRADALIGI 1199
E Q I + + E AD G+
Sbjct: 1163 ELAV-HAQFITTTFRPELLESADKFYGV 1189
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 124 bits (310), Expect = 7e-28
Identities = 215/1019 (21%), Positives = 431/1019 (42%), Gaps = 167/1019 (16%)
Query: 141 ESISVK-KPKERTQFFEEISTSGELIGEYEEKKRKLQ-KAEEDAQFNFNKKK-------- 190
E++ +K K KE ++++ +L E K+K+Q E++ Q FN+
Sbjct: 647 ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG 706
Query: 191 --------NIAAERRQAKLEKE---EAERYQSLLEE-LKMNKIQLQLFQLYHNEKKIHLL 238
N+ E + L+KE E E ++L EE + +++++ ++ K+I
Sbjct: 707 KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766
Query: 239 NTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQY 298
+ +L + + + H E+ V+ +E G L T+ KS + + +
Sbjct: 767 SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLH 826
Query: 299 IKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEI 358
+ ++ L++ + + I + K+ K + + AL+TEL+ + ++++E +
Sbjct: 827 MDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERL 886
Query: 359 LHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQ 418
++E QL+ + V ++ +T++L++ E KT + K+ +Q
Sbjct: 887 ----NEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942
Query: 419 GNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELN 478
Q+K I D +E + ++ LK+ ++ TL +I + SR E
Sbjct: 943 IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG 1002
Query: 479 LIRSELQN--AGIDTHEGKRQQKRAEVLEHLKRLYPDSVF----GRLFDLCHPIHKKYQL 532
+ E Q GID K+Q A+ + L D+ ++F L I +K +L
Sbjct: 1003 ETKDEFQQKMVGID----KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSL---IQEKNEL 1055
Query: 533 AVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCK 592
+ + +++ E++ D LKE +I+ E EL +
Sbjct: 1056 Q------QMLESVIAEKEQLKTD----LKE--------------NIEMTIENQEEL---R 1088
Query: 593 MVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVI 652
++ D +K Q ++++ E+ + +G L +
Sbjct: 1089 LLGDELKKQ----QEIV----------------------AQEKNHAIKKEGELSRTCDRL 1122
Query: 653 SGGSSDLKYKARCWDEK--ELKNLRDRRSQ---KIQELKGLMKTLR-KETDLKQIQTLIQ 706
+ LK K++ EK +L N+++ S+ KI E++ L L+ KE L+ ++T
Sbjct: 1123 AEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERL 1182
Query: 707 GTQTRLKYSQNELEMIKKKHLV------AFYQEQSQLQSELLNIESQCIMLSEGIKERQR 760
+L + E++ I K+ V +F E+ L+ + IE+ + E +K
Sbjct: 1183 ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHI 1242
Query: 761 RIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEI-----DQKRL------- 808
+KE QE ID++ + + + I N ++ E H K Q+EI +Q+ L
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQII---NTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299
Query: 809 EFEKQKTRLNVQLEYSRSHLKKKLNKIN----TLKETIQKGSEDIDHLKKAEENCLQTVN 864
E ++ L + E S + L +I L E Q+ E+I L K +N L+T+
Sbjct: 1300 ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDN-LKTIK 1358
Query: 865 E-LMAKQQQLKD-IRVT----QNSSAEKVQ-----------TQIEEERKKFLAVDREVGK 907
E L K QLK+ IR T Q S +++ Q T+I E ++F D + +
Sbjct: 1359 EALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR 1418
Query: 908 LQKEVVSIQTSLEQKR-------LEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAE 960
++ E++ + L++ EK +L +V E L ++ +I+ + TE E
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478
Query: 961 STQATIDIYEKEEAF----------EIDYSSLKEDLKALQSD-----QEI-EAHLRLLLQ 1004
A + E+EE E + S++++ L+A+ QEI E + ++
Sbjct: 1479 LKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIK 1538
Query: 1005 QVASQEDIL--LKTAAPNLRALEN-LKTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
Q++ ++ + LK + +A ++ L+++ K E T+ + S++E ++ +E E++K+
Sbjct: 1539 QISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR 1597
Score = 105 bits (262), Expect = 3e-22
Identities = 217/1073 (20%), Positives = 443/1073 (41%), Gaps = 191/1073 (17%)
Query: 104 EFRFNDNLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGE 163
E N+ L + ++EL+ + V+ + Q E + + ++ F E +
Sbjct: 732 EVEENEALREEVILLSELKSLPSEVERLRKEI-QDKSEELHIITSEKDKLFSEVVHKESR 790
Query: 164 LIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAK-LEKEEAERYQSLLEEL-KMNKI 221
+ G EE + K ++D + K+ E + K L + ++Y+ +LEE +MN+
Sbjct: 791 VQGLLEE----IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ- 845
Query: 222 QLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTE 281
++ + K+ ++ L + +LS K + L V+ R E L QL+ +
Sbjct: 846 -----EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRD 900
Query: 282 KELKSVE---TLLNQKRPQY---IKAKENTSHHLKKL--------DVAKKSIKDSEKQCS 327
L++VE TL+ +K Q +K LK+L D K I D+
Sbjct: 901 STLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNI 960
Query: 328 KQEDDIKALETELADLDAAWRSFEKQIEEEI-----------------------LHKKRD 364
++ ++ L + + +I EE+ + KK+D
Sbjct: 961 DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD 1020
Query: 365 IELEASQL----DRYKELKEQVRKKVATMTQQLEKLQW----------EQKTDEER---L 407
+E + +Q + E+ EQ RK + ++ Q+ +LQ + KTD + +
Sbjct: 1021 LEAKNTQTLTADVKDNEIIEQQRK-IFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 408 AFEKRRHGEVQGN-LKQIKEQIEDHKKR-IEKLEEYTKTC------MDCLKEKKQQEETL 459
E + + G+ LK+ +E + K I+K E ++TC + LKEK QQ +
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 460 VDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEV-LEHLKRLYPDSVFGR 518
++ + MSE +++N E++N K + K E+ LEH++
Sbjct: 1140 QQQLLNVQEEMSEMQKKIN----EIENL-------KNELKNKELTLEHMET--------E 1180
Query: 519 LFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIR-FLKEERA---EPETFLALD 574
+L +++ Y+ + R + + S + +D +R +++E A + + L +
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIA 1240
Query: 575 YLDIKPINERLRELKGC--KMVIDVIKTQ------------FPQLKKVIQFVCGNGLVCE 620
++ +K E + EL+ + +I TQ P L + + + V E
Sbjct: 1241 HIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300
Query: 621 TMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQ 680
T E + L +++ D T + E E L ++ +
Sbjct: 1301 TQETMNELELL---TEQSTTKDSTTLARI------------------EMERLRLNEKFQE 1339
Query: 681 KIQELKGL------MKTLRKETDLK--QIQTLIQGTQTRLKYSQNELEM---IKKKH--- 726
+E+K L +KT+++ ++K Q++ I+ T +++ SQ++ E +K+K
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNET 1399
Query: 727 --LVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVE--DDIFQHFCE 782
+V+ ++ S LL IE + + LS+ ++E +K ++ D ++ ++ Q +
Sbjct: 1400 TKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESD 1459
Query: 783 EIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETI 842
++ ENI+E KH++ ++E+ ++Q+ +N L+ L++ T TI
Sbjct: 1460 QLK-ENIKEIVAKHLETEEELKVAHCCLKEQEETIN--------ELRVNLSEKETEISTI 1510
Query: 843 QKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVD 902
QK E I+ + + E+ K++Q ++++ Q +E RK A D
Sbjct: 1511 QKQLEAIN------DKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRK---AKD 1561
Query: 903 REVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGS----LDDIIEVEMGTE 958
S S+E K LE N L + + ++I+I++ + + +++E
Sbjct: 1562 -----------SALQSIESKMLELTNRLQESQ-EEIQIMIKEKEEMKRVQEALQIERDQL 1609
Query: 959 AESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAA 1018
E+T+ + + +E+ E +Y LK + A+ QE + L +Q +Q+ L
Sbjct: 1610 KENTKEIVA--KMKESQEKEYQFLK--MTAVNETQEKMCEIEHLKEQFETQKLNLENIET 1665
Query: 1019 PNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
N+R + L ++ + T + R + E +Q+K+ + T+ E
Sbjct: 1666 ENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
Score = 102 bits (254), Expect = 2e-21
Identities = 198/988 (20%), Positives = 398/988 (40%), Gaps = 178/988 (18%)
Query: 165 IGEYEEKKRKLQKAEEDAQFN-FNKKKNIAAERRQAKLEKEEAER-YQSLLEELKMNKIQ 222
+ E+E +RK +K +E + + KN+ + A++ ++ E S +E L+ + Q
Sbjct: 534 LDEFEALERKTKKDQEMQLIHEISNLKNLV---KHAEVYNQDLENELSSKVELLREKEDQ 590
Query: 223 LQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHH----------ENIVKARKKEHGM 272
++ Q Y + +K LE++ DLS ES+ E + K+E
Sbjct: 591 IKKLQEYIDSQK-------LENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF 643
Query: 273 LTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDD 332
L + + ++++K + T Y + + + + +L+ KK D EK+ ++
Sbjct: 644 LRSENLELKEKMKELATT-------YKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696
Query: 333 IKALETELAD------------LDAAWRSFEKQIEEEILHKK--RDIELEASQLDRYKEL 378
I L T L D L+ +K++ +E+ + R+ + S+L
Sbjct: 697 ITKL-TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSE 755
Query: 379 KEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGE--VQGNLKQIKEQIED------ 430
E++RK++ +++L + T E+ F + H E VQG L++I + +D
Sbjct: 756 VERLRKEIQDKSEELHII-----TSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS 810
Query: 431 -HKKRIEKLEEYTKTCMDCLKEKK---QQEETLVDEIEKTKSRMSEFNEELNLIRSELQN 486
+K ++ + + MD ++ K ++ E + EI +F+ L +++EL
Sbjct: 811 NYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSY 870
Query: 487 AGIDTHEGKRQ-QKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAI 545
+ E R+ Q+R +E LK ++ R T
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKE--------------------------QLENRDSTLQ 904
Query: 546 VVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQL 605
V EK I ++ E L + D+K + E L+ + QL
Sbjct: 905 TVEREKTL---ITEKLQQTLEEVKTLTQEKDDLKQLQESLQ-------------IERDQL 948
Query: 606 KKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARC 665
K I + +T E+ R+ S + Q+T+ LKS + S +L +
Sbjct: 949 KSDIHDTVNMNI--DTQEQLRNALESLKQHQETINT-----LKSKISEEVSRNLHME--- 998
Query: 666 WDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKK 725
+N + + + Q++ G+ K +++ + K QTL + NE+ + +++
Sbjct: 999 ------ENTGETKDEFQQKMVGIDK--KQDLEAKNTQTLTADVK------DNEI-IEQQR 1043
Query: 726 HLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQ------- 778
+ + QE+++LQ L ++ ++ L +KE E QE++ + D++ +
Sbjct: 1044 KIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQ 1103
Query: 779 ---HFCEEIG-----VENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKK 830
H ++ G + + E E K ++ Q++ EKQ+ LNVQ E S ++K
Sbjct: 1104 EKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQ------EKQQQLLNVQEEMSE--MQK 1155
Query: 831 KLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQ 890
K+N+I LK ++ ++H++ Q +NE +++K I + +++Q
Sbjct: 1156 KINEIENLKNELKNKELTLEHMETERLELAQKLNE---NYEEVKSI-TKERKVLKELQKS 1211
Query: 891 IEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDI 950
E ER RE+ E +QT E K H + ++ + + I
Sbjct: 1212 FETERDHLRGYIREI-----EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQII 1266
Query: 951 IEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQE 1010
++ Q I + +E+ L ++K + QE L LL +Q +++
Sbjct: 1267 NTQDLEKSHTKLQEEIPVLHEEQ-------ELLPNVKEVSETQETMNELELLTEQSTTKD 1319
Query: 1011 DILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCF 1070
L +E L+ + +KFQES + ++ KE R + +K+ Q
Sbjct: 1320 STTLARI-----EMERLR-LNEKFQESQEEIKSLTKE----RDNLKTIKEALEVKHDQLK 1369
Query: 1071 EHVSISIDQIYKKLCRNNSAQAFLSPEN 1098
EH+ ++ +I + + + +N
Sbjct: 1370 EHIRETLAKIQESQSKQEQSLNMKEKDN 1397
Score = 100 bits (248), Expect = 1e-20
Identities = 187/996 (18%), Positives = 407/996 (40%), Gaps = 154/996 (15%)
Query: 146 KKPKERTQFFEEISTSGELIGEYEEKKRKLQKAE--------------EDAQFNFNKKKN 191
+K ++ EE+S + I E E K +L+ E + N+ + K+
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197
Query: 192 IAAERRQAK-LEKE---EAERYQSLLEELKMNKIQL-QLFQLYHNEKKIHLLNTKLEHVN 246
I ER+ K L+K E + + + E++ +Q + ++ H K H ++ +
Sbjct: 1198 ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEH--QETIDELR 1255
Query: 247 RDLSVKRESLSHHENIVKARKK----------EHGML--TRQLQQTEKELKSVETLLNQK 294
R +S K + + +++ K+ K E +L +++ +T++ + +E L Q
Sbjct: 1256 RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315
Query: 295 RPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKA-----------LETELADL 343
+ +L+ + ++ K +K+ D++K L+ + +
Sbjct: 1316 TTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET 1375
Query: 344 DAAWRSFEKQIEEEILHKKRDIELE--ASQLDRYKELKEQVRKKVATMTQQLEKLQWEQK 401
A + + + E+ + K++D E S+++++K K+ ++ L K E
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKP-KDSALLRIEIEMLGLSKRLQESH 1434
Query: 402 TDEERLAFEK----RRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEE 457
+ + +A EK R +Q Q+KE I++ + + EE K CLKE+++
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETIN 1494
Query: 458 TLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQ---QKRAEVLEHLKRLYP-- 512
L + + ++ +S ++L I +LQN + +E + Q ++ +EV E + L
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK 1554
Query: 513 ----------DSVFGRLFDLCHPIHKKYQ-----LAVTKVFGRFITAIVVASEKV---AK 554
S+ ++ +L + + + + + + R A+ + +++ K
Sbjct: 1555 EHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614
Query: 555 DCIRFLKEERAEPETFLALDYLD---------------------------------IKPI 581
+ + +KE + + FL + ++ + +
Sbjct: 1615 EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQIL 1674
Query: 582 NERLRELKG-------CKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPE 634
+E L E++ + V + +K + QLK+ ++ L E EE + + + E
Sbjct: 1675 HENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL--EKQEELKIVHMHLKE 1732
Query: 635 RQKTV-ALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLR 693
Q+T+ L G + K+ IS DL++ ++LK + R + LK +T+
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHM-HLKEQQETID 1791
Query: 694 KETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSE 753
K ++ ++ +L Q +LE K QE+ Q EL E Q I L +
Sbjct: 1792 K------LRGIVSEKTDKLSNMQKDLENSNAK-----LQEKIQ---ELKANEHQLITLKK 1837
Query: 754 GIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQ 813
+ E Q+++ E ++ +++D EI N+ + +++++ + + ++R
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKER----DN 1893
Query: 814 KTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNE-LMAKQQQ 872
R+ L+ R LK+ L + IQ+ + L K + + + E + K Q
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 873 LKDIRVTQNSSAEKVQTQIEEERKKFLAVDR-------------EVGKLQKEVVSIQTSL 919
+ DI+ + S +++Q +I+E +KK L + R E+ +L+K+ + S+
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM 2013
Query: 920 EQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDY 979
+ R++ L EI +++ D++ ++ + E Q + E A +
Sbjct: 2014 QSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM-IARDRQN 2072
Query: 980 SSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLK 1015
+K + + L Q+ HL L++ S+ LLK
Sbjct: 2073 HQVKPEKRLLSDGQQ---HLTESLREKCSRIKELLK 2105
Score = 97.8 bits (242), Expect = 6e-20
Identities = 169/879 (19%), Positives = 366/879 (41%), Gaps = 117/879 (13%)
Query: 117 YIAELEKIGIIVKAQNCLVF------QGTVESISVKKPKERTQFFEEISTSGELIGEYEE 170
YI E+E G+ K + + Q T++ + + E+T +I + +L + +
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELR-RSVSEKTA---QIINTQDLEKSHTK 1277
Query: 171 KKRKLQKAEEDAQFNFNKKKNIAAERRQAKLE---KEEAERYQSLLEELKMNKIQL-QLF 226
+ ++ E+ + N K+ + +LE ++ + + L ++M +++L + F
Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337
Query: 227 QLYHNE-KKIHLLNTKLEHVNRDLSVKRESLSHH--ENIVKARKKEHGMLTRQLQQTEKE 283
Q E K + L+ + L VK + L H E + K ++ + ++Q Q +
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQ----SKQEQSLNMK 1393
Query: 284 LKSVETLLNQKRPQYIKAKENT--SHHLKKLDVAKK--SIKDSEKQCSKQEDDIKALETE 339
K ET + K K++ ++ L ++K+ D K +K++DD++ L+
Sbjct: 1394 EKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV 1453
Query: 340 LADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWE 399
L + K+I + L + ++++ L +E ++R ++ ++ +Q +
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 400 QKTDEERLA--FEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEE 457
+ ++L ++ E Q N+KQI E E ++ +L+++ KE ++ ++
Sbjct: 1514 LEAINDKLQNKIQEIYEKEEQFNIKQISEVQE----KVNELKQF--------KEHRKAKD 1561
Query: 458 TLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFG 517
+ + IE S+M E L + E+Q + E KR Q+ ++ + +
Sbjct: 1562 SALQSIE---SKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA 1618
Query: 518 RLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKE---------ERAEPE 568
++ + K+YQ +TA+ EK+ + I LKE E E E
Sbjct: 1619 KMKE---SQEKEYQFLK-------MTAVNETQEKMCE--IEHLKEQFETQKLNLENIETE 1666
Query: 569 TFLALDYL--DIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEAR 626
L +++ + +E + V + +K + QLK+ ++ L E EE +
Sbjct: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL--EKQEELK 1724
Query: 627 HIALSGPERQKTV-ALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRR------- 678
+ + E Q+T+ L G + K+ IS DL++ ++LK + R
Sbjct: 1725 IVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLK 1784
Query: 679 --SQKIQELKGLM-----KTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKK------K 725
+ I +L+G++ K + DL+ +Q LK ++++L +KK K
Sbjct: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQK 1844
Query: 726 HLVAFYQEQSQLQSELLNI---ESQCIMLSEGIKERQRRIKEFQEKID---------KVE 773
+ Q + Q++ + L + E + + L++ + E +K ++ D K+E
Sbjct: 1845 KVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLE 1904
Query: 774 DDIFQHFCEEIGVENI---------REFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYS 824
D + +E ++ R +H + ++ +K E Q + + L+ S
Sbjct: 1905 RDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKS 1964
Query: 825 RSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSA 884
+ L+KK+ ++ + + + ED++ K Q + A+ ++ +R+
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024
Query: 885 EKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKR 923
+K+ +EE R V K + E+ I+ SL+ +R
Sbjct: 2025 KKLHESLEE--------IRIVAKERDELRRIKESLKMER 2055
Score = 87.8 bits (216), Expect = 6e-17
Identities = 161/828 (19%), Positives = 349/828 (42%), Gaps = 106/828 (12%)
Query: 156 EEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEE 215
E+ T +L G EK KL ++D + N N K Q K+++ +A +Q + +
Sbjct: 1785 EQQETIDKLRGIVSEKTDKLSNMQKDLE-NSNAKL-------QEKIQELKANEHQLITLK 1836
Query: 216 LKMNKIQLQLFQLYHNEKKIH---LLNTKLEHVNRDLSVK-RESLSHHENIVKAR----- 266
+N+ Q ++ ++ +K+I L +KLE N +L+ K E+L ++++K R
Sbjct: 1837 KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR 1896
Query: 267 -----KKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKD 321
K E L LQ+T+ ++ L R + KE +K+ I D
Sbjct: 1897 VEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISD 1956
Query: 322 SEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQ 381
+K K +D+++ EL ++ E ++L K D+ + +++ ++LK+Q
Sbjct: 1957 IQKDLDKSKDELQKKIQEL-----------QKKELQLLRVKEDVNMSHKKINEMEQLKKQ 2005
Query: 382 VRKKVATMTQ------QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQI------- 428
+ +M QL K E + +A E+ ++ +LK ++Q
Sbjct: 2006 FEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 429 -----EDHKKRIEK--LEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIR 481
++H+ + EK L + + + L+EK + + E+ K S M + E LN +
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSR----IKELLKRYSEMDDHYECLNRLS 2121
Query: 482 SELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFG---RLFDLCHPIHKKYQLAVTKVF 538
+L+ E + K L +L+ + + +F R H I KK + ++
Sbjct: 2122 LDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLS--- 2178
Query: 539 GRFITAIVVAS-EKVAKDCIRFLKEERAEPETFLALDYL--DIKPINERLRELKGCK--- 592
++T I E + K + F+ E + E + + +L D + LR+LK +
Sbjct: 2179 --YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMD 2236
Query: 593 -----MVIDVIKTQFPQLKKVIQFVCGNGL-VCETMEEARHIAL------SGPERQKTVA 640
++ D +++FP +K Q V N + + +EE + +G +++
Sbjct: 2237 LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRI 2296
Query: 641 LDGTLFLKSGVISGGSSDLKYKARC------WDEKELKNLRDRRSQKIQELKGLMKTLRK 694
F + +I+ + +++ R W E++LK+L+++ + + + L +L
Sbjct: 2297 CQVNNFFNNRIIAIMNESTEFEERSATISKEW-EQDLKSLKEKNEKLFKNYQTLKTSLAS 2355
Query: 695 ETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQL--QSELLNIESQCIMLS 752
+ + + +Q E I++ ++S + +S+++ ++ + + +
Sbjct: 2356 GAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTN 2415
Query: 753 EGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGV------ENIREFENKHVKRQQEIDQK 806
+ I + Q ++ E + ++K ++ I Q +++ + E I + + K VK E +
Sbjct: 2416 DIIAKLQAKVHESNKCLEKTKETI-QVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKN 2474
Query: 807 RLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNEL 866
EFEK+ + +EY + I L+E +++ + D +E Q N+
Sbjct: 2475 AKEFEKEISATKATVEYQK-------EVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKP 2527
Query: 867 MAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVS 914
+ ++ T+ + ++E+E K + ++ K + E++S
Sbjct: 2528 LTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLS 2575
Score = 80.1 bits (196), Expect = 1e-14
Identities = 205/1090 (18%), Positives = 454/1090 (41%), Gaps = 173/1090 (15%)
Query: 120 ELEKIGIIVKAQNCLVFQGTVESIS-VKKPKERTQFFEEISTSGELIGEYEEKKRKLQKA 178
E++++ ++ + + + T E ++ +K+ +E+ F +++ + E +EK +++
Sbjct: 1594 EMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA----VNETQEKMCEIEHL 1649
Query: 179 EEDAQFNFNKKKNIAAER-RQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHL 237
+E + +NI E R ++ E E +S+ +E + + ++ ++ K +L
Sbjct: 1650 KEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENL 1709
Query: 238 LNT---------KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVE 288
T +L+ V+ L +E++ IV + E + + L+ + LK+ +
Sbjct: 1710 RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQD 1769
Query: 289 TLLNQK---RPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDA 345
+ ++ ++K ++ T L+ + V++K+ K S Q + + K L+ ++ +L A
Sbjct: 1770 LKIQEELRIAHMHLKEQQETIDKLRGI-VSEKTDKLSNMQKDLENSNAK-LQEKIQELKA 1827
Query: 346 AWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQ-QLEKLQWEQKTDE 404
E +++ K+D+ ++ ++LK+Q++ + T+++ ++E L QK E
Sbjct: 1828 N--------EHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE 1879
Query: 405 ---ERLAFEKRRHG--EVQGNLK----QIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQ 455
E + K R V+ LK Q+KE +++ K R ++++ KT KE K+
Sbjct: 1880 NLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKET 1939
Query: 456 EETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQ-----------QKRAEVL 504
+ L ++I + ++S+ ++L+ + ELQ + + + Q K+ +
Sbjct: 1940 VDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Query: 505 EHLKRLYP------DSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKD--- 555
E LK+ + SV F L +H+ + R + S K+ +D
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFI 2059
Query: 556 ------CIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVI 609
R + + +PE L D + + E LRE C + +++K ++ ++
Sbjct: 2060 ATLREMIARDRQNHQVKPEKRLLSD--GQQHLTESLREK--CSRIKELLK-RYSEMDD-- 2112
Query: 610 QFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKA--RCWD 667
+ C N L + +E E QK +++ L + + + A RC
Sbjct: 2113 HYECLNRLSLDLEKEI--------EFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSM 2164
Query: 668 E-----KELK-------NLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYS 715
E K+LK +++ + + I + + M + + K++ IQ Q
Sbjct: 2165 EFHRIMKKLKYVLSYVTKIKEEQHESINKFE--MDFIDEVEKQKELLIKIQHLQQDCDVP 2222
Query: 716 QNELEMIKKKHLVAFYQEQ---SQLQSELLNIESQCIMLSEGIKERQRRIKEFQEK---I 769
EL +K + + E+ +SE +I+++ + KE + ++E+ I
Sbjct: 2223 SRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDI 2282
Query: 770 DKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLK 829
+K+++ I + V N F N+ + E EFE++ ++ + E LK
Sbjct: 2283 EKLKNGIQKENDRICQVNNF--FNNRIIAIMNE----STEFEERSATISKEWEQDLKSLK 2336
Query: 830 KKLNKI----NTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAE 885
+K K+ TLK ++ G++ ++ + +N T A Q + IR +NS E
Sbjct: 2337 EKNEKLFKNYQTLKTSLASGAQ-VNPTTQDNKNPHVTSR---ATQLTTEKIRELENSLHE 2392
Query: 886 KVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLE--QKRLEKHNLLLDCKVQDIEIILL 943
++ + +E K + K+QKE+ + Q ++ + N L+ + I++
Sbjct: 2393 AKESAMHKESK--------IIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQV--- 2441
Query: 944 SGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLL 1003
L D +V +G + KEE ++ +K DL+ +++ +E E +
Sbjct: 2442 ---LQD--KVALGAKPY----------KEEIEDLKMKLVKIDLEKMKNAKEFEKEISATK 2486
Query: 1004 QQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASR------------------ 1045
V Q+++ ++ NLR + + E TD +++
Sbjct: 2487 ATVEYQKEV-IRLLRENLRRSQQAQDT-SVISEHTDPQPSNKPLTCGGGSGIVQNTKALI 2544
Query: 1046 ---------KEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLSP 1096
KE +Q+ EQ+ K++ +L + +H+S + ++ + + +
Sbjct: 2545 LKSEHIRLEKEISKLKQQNEQLIKQKNELLSN-NQHLSNEVKTWKERTLKREAHKQVTCE 2603
Query: 1097 ENPEEPYLEG 1106
+P+ P + G
Sbjct: 2604 NSPKSPKVTG 2613
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 114 bits (284), Expect = 7e-25
Identities = 196/999 (19%), Positives = 420/999 (42%), Gaps = 134/999 (13%)
Query: 149 KERTQFFEEISTSGELIGEYEEKKRKL------------------QKAEEDAQFNFNKKK 190
+E+ E++ EL E EE + +L ++ EE Q N+KK
Sbjct: 887 EEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946
Query: 191 NIAAERR--QAKLEKEEAERYQSLLE----ELKMNKIQLQLFQLYHNEKKI----HLLNT 240
+ A + + +L++EE R + LE E K+ K++ ++ L K L+
Sbjct: 947 KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006
Query: 241 KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIK 300
++ + L+ + E +N+ K R K+ M++ ++ +KE K+ + L KR
Sbjct: 1007 RIAECSSQLAEEEEKA---KNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR----- 1058
Query: 301 AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILH 360
KLD ++D + Q D++K +LA + + + ++E LH
Sbjct: 1059 ----------KLDGETTDLQDQIAELQAQIDELKL---QLAKKEEELQGALARGDDETLH 1105
Query: 361 KK------RDIELEASQL----DRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFE 410
K R+++ + ++L + K + + K+ ++++LE L+ E + + A +
Sbjct: 1106 KNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ 1165
Query: 411 K----RRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKT 466
+ +R EV K ++E+ ++H+ +I+ + + T ++ L E+ +Q + +EK
Sbjct: 1166 QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225
Query: 467 KSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLE-HLKRLYPDSVFGRLFDLCHP 525
K + N+EL LQ ++ E KR++ A+V E H K D + L +
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAES-EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASK 1284
Query: 526 IHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLD-IKPINER 584
+ + T + I A + + + +E + ET L+ I+ + E
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE 1344
Query: 585 LREL-----------KGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGP 633
L K + + +++Q KK + G E++EEA+ L
Sbjct: 1345 KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGT---IESLEEAKKKLLKDA 1401
Query: 634 E------RQKTVALDGTLFLKSGV---ISGGSSDLKYKARCWDEKELKNLRDRRSQKIQE 684
E +K +A D K+ + + + DL ++ + E K + + Q + E
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK--QKKFDQLLAE 1459
Query: 685 LKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNI 744
K + +E D + + + T+ L ++ E ++ K F ++ QL++++ ++
Sbjct: 1460 EKSISARYAEERDRAEAEAREKETKA-LSLARALEEALEAKE--EFERQNKQLRADMEDL 1516
Query: 745 ESQCIMLSEGIKERQR-------RIKEFQEKIDKVEDDIFQHFCEEIGVE-NIR----EF 792
S + + + E ++ +++E + +++++ED++ ++ +E N++ +F
Sbjct: 1517 MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF 1576
Query: 793 ENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHL 852
E R ++ ++K+ KQ L +LE R + ++ ++ I+
Sbjct: 1577 ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA 1636
Query: 853 KKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV 912
KA + ++ + +L A+ + + +S +++ Q +E KK +++ E+ +LQ+E+
Sbjct: 1637 NKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEEL 1696
Query: 913 VSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKE 972
S + + E+ L EI + +++ + EA Q ++ E++
Sbjct: 1697 ASSERARRHAEQERDELA-------DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 973 EAFE----------IDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLR 1022
E + +L +L A +S + + R QQ+ Q K L+
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR---QQLERQN----KELKAKLQ 1802
Query: 1023 ALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKR 1061
LE V+ KF+ + A EA K +L Q ++ K+R
Sbjct: 1803 ELEG--AVKSKFKATISALEA--KIGQLEEQLEQEAKER 1837
Score = 96.3 bits (238), Expect = 2e-19
Identities = 183/866 (21%), Positives = 368/866 (42%), Gaps = 135/866 (15%)
Query: 240 TKLEHVNRDLSVKRESLSHHENIVKARKKEHGM------LTRQLQQTEKELKSVETLLNQ 293
TK++ + + + E + E ++K ++K+ + + R+ QQ +E + L
Sbjct: 839 TKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQA 898
Query: 294 KRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQ 353
+ + +A+E + K ++ + D E + ++E+ + L+ E + A + E+Q
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 354 I-EEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKR 412
+ EEE +K +E ++ + K+++E+ + + Q K E+K E+R+A
Sbjct: 959 LDEEEGARQKLQLEKVTAEA-KIKKMEEE----ILLLEDQNSKFIKEKKLMEDRIA---- 1009
Query: 413 RHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSE 472
E L + +E+ K + K+ + + L+E+ ++EE E+EK K ++
Sbjct: 1010 ---ECSSQLAEEEEK----AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 473 FNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQL 532
+L +ELQ A ID + + +K E+ L R ++ +HK L
Sbjct: 1063 ETTDLQDQIAELQ-AQIDELKLQLAKKEEELQGALARGDDET-----------LHKNNAL 1110
Query: 533 AVTKVFGRFITAI------VVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLR 586
V + I + AS A+ R L EE +T L D LD + LR
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELE-DTLDTTAAQQELR 1169
Query: 587 ELKGCKMVIDVIKTQFPQLKKVIQFVCGN-GLVCETMEEARHIALSGPERQKTVALDGTL 645
+ + + +LKK ++ N + M + AL Q A
Sbjct: 1170 TKR---------EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQA----- 1215
Query: 646 FLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLI 705
++KA EK + L + E+K +++ ++ E++ K+ +
Sbjct: 1216 -------------KRFKANL--EKNKQGLETDNKELACEVK-VLQQVKAESEHKRKKLDA 1259
Query: 706 QGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIK-- 763
Q + K S+ + + V ++ S+LQ+EL N+ + +L E K+ + K
Sbjct: 1260 QVQELHAKVSEGD------RLRVELAEKASKLQNELDNVST---LLEEAEKKGIKFAKDA 1310
Query: 764 -----EFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLN 818
+ Q+ + ++++ Q + + E +N ++Q+E ++ R EKQ L
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 819 VQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHL-KKAEENCL------QTVNELMAKQQ 871
QL ++ + L I +L+E +K +D + L ++ EE L +T N L QQ
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRL---QQ 1427
Query: 872 QLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLL 931
+L D+ V + +V + +E+++KKF D+ + +++ +S + + E+ R E
Sbjct: 1428 ELDDLTVDLDHQ-RQVASNLEKKQKKF---DQLLA--EEKSISARYAEERDRAE-----A 1476
Query: 932 DCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQS 991
+ + ++ + + L+ +L++ +E + E ++ Q D+ D S K+D+ ++
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADME--------DLMSSKDDVG--KN 1526
Query: 992 DQEIEAHLRLLLQQVASQ-------EDILLKTAAPNLRALENLKTVRDKFQESTDAFEAS 1044
E+E R L QQV ED L T LR N++ ++ +F+ +
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Query: 1045 R--------KEARLCRQEFEQVKKRR 1062
K+ R E E +K+R
Sbjct: 1587 NEEKKRLLIKQVRELEAELEDERKQR 1612
Score = 93.2 bits (230), Expect = 1e-18
Identities = 192/996 (19%), Positives = 401/996 (40%), Gaps = 164/996 (16%)
Query: 120 ELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAE 179
+LEK+ K + +E + K KE+ + I+ + E EEK + L K
Sbjct: 970 QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIR 1029
Query: 180 -------EDAQFNFNKKKNIAAERRQAKLE--------KEEAERYQSLLEELKM------ 218
D + K++ E +AK + +++ Q+ ++ELK+
Sbjct: 1030 NKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE 1089
Query: 219 ------------------------NKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRE 254
++Q Q+ +L + + K E RDLS + E
Sbjct: 1090 EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELE 1149
Query: 255 SL-SHHENIVKARKKEHGMLTRQLQQT-------EKELKSVETLLNQKRPQYIKAKENTS 306
+L + E+ + + + T++ Q+ E+E K+ E + R ++ A E S
Sbjct: 1150 ALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELS 1209
Query: 307 HHL----------------------------KKLDVAKKSIKDSEKQCSKQEDDIKA--- 335
L K L K + K+ Q ++ A
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269
Query: 336 ----LETELA--------DLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVR 383
L ELA +LD E+ ++ I K LE+ D + L+E+ R
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETR 1329
Query: 384 KK--VATMTQQLEK----LQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK 437
+K +++ +QLE+ LQ +Q+ +EE +++ +Q L K++++D IE
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389
Query: 438 LEEYTKTCM---DCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEG 494
LEE K + + L ++ +++ D++EKTK+R+ + ++L + + + ++
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ--VASNLE 1447
Query: 495 KRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAK 554
K+Q+K ++L K S+ R + + + TK + + + + +
Sbjct: 1448 KKQKKFDQLLAEEK-----SISARYAEERDRAEAEAREKETKALS--LARALEEALEAKE 1500
Query: 555 DCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCG 614
+ R K+ RA+ E ++ K ++E + + + ++ ++TQ +L+ +Q
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED 1560
Query: 615 NGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNL 674
L E +A ER + K +I + +A DE++ + L
Sbjct: 1561 AKLRLEVNMQAMKAQF---ERDLQTRDEQNEEKKRLLI---KQVRELEAELEDERKQRAL 1614
Query: 675 RDRRSQK----IQELKGLMKTLRKETD--LKQIQTLIQGTQTRLKYSQNELEMIKKKHLV 728
+K +++L+ ++ K D +KQ++ L Q ++K Q ELE +
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL----QAQMKDYQRELEEARASRDE 1670
Query: 729 AFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIG-VE 787
F Q + + + +L ++E++ + L E + +R + +++ D++ D+I + ++
Sbjct: 1671 IFAQSK-ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729
Query: 788 NIREFENKHVKRQQEIDQKRLEFEKQKTR----------LNVQLEYSRSHLKKKLNKINT 837
R E + + ++E+++++ E R LN +L RS +K N
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ 1789
Query: 838 LKETIQKGSEDIDHLKKAEENCLQ-TVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERK 896
L+ ++ + L+ A ++ + T++ L AK QL++ Q+E+E K
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE--------------QLEQEAK 1835
Query: 897 KFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMG 956
+ A ++ V + +K++ I +E +R + + + L L++ E
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEE--AEEEA 1893
Query: 957 TEAESTQATI-----DIYEKEEAFEIDYSSLKEDLK 987
T A +++ + D E E + S+LK L+
Sbjct: 1894 TRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 55.8 bits (133), Expect = 2e-07
Identities = 69/365 (18%), Positives = 156/365 (42%), Gaps = 43/365 (11%)
Query: 170 EKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLY 229
+KK ++ + +AQ K ++ KL+ + + YQ LEE + ++ ++ Q
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD-YQRELEEARASRDEI-FAQSK 1676
Query: 230 HNEKKIHLLNTKLEHVNRDLSVKRESLSHHEN------------------IVKARKKEHG 271
+EKK+ L ++ + +L+ + H E ++ +++
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1736
Query: 272 MLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQED 331
+ + ++ E+E ++E L ++ R ++ + + A+KS ++ +Q +Q
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKS-DNARQQLERQNK 1795
Query: 332 DIKALETELADLDAAWRSFEKQ----IEEEILHKKRDIELEASQLDRYKELKEQVRKKVA 387
++KA +L +L+ A +S K +E +I + +E EA + +L + KK+
Sbjct: 1796 ELKA---KLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK 1852
Query: 388 TMTQQLEKLQWEQKTDEERLAFE-KRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCM 446
+ Q+E DE R A + K + + +KQ+K Q+E+ ++ + +
Sbjct: 1853 EIFMQVE--------DERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Query: 447 DCLKEKKQQEETLVDEIEKTKSRM------SEFNEELNLIRSELQNAGIDTHEGKRQQKR 500
L + + E L E+ K+R+ S + + L+ A ++ + + K
Sbjct: 1905 RELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKT 1964
Query: 501 AEVLE 505
++V E
Sbjct: 1965 SDVNE 1969
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 113 bits (282), Expect = 1e-24
Identities = 215/1007 (21%), Positives = 414/1007 (41%), Gaps = 130/1007 (12%)
Query: 140 VESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQA 199
+E++ + E+ Q E++ EL E EE + +L +++ + +A
Sbjct: 871 METLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE--------ICHDLEA 922
Query: 200 KLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKR----ES 255
++E+EE ER Q L E K + +Q + E++ +LE V + +K+ +
Sbjct: 923 RVEEEE-ERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQI 981
Query: 256 LSHHENIVKARKKEH-----GMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLK 310
+ +N A++K+ T L + E++ KS+ L N+ +E
Sbjct: 982 ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE------- 1034
Query: 311 KLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQI---EEEILHKKRDIEL 367
+L +K ++ EK K E D L ++A+L A + Q+ EEE+ +E
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE 1094
Query: 368 EASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQ 427
EA+Q K KK+ + Q+ +LQ + +++ +++ ++ L+ +K +
Sbjct: 1095 EAAQ-------KNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE 1147
Query: 428 IED-----------HKKRIEK-------LEEYTKTCMDCLKEKKQQEETLVDEI------ 463
+ED KR ++ LEE KT ++E +Q+ V+E+
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQ 1207
Query: 464 -EKTKSRMSEFNEELNLIRSELQN------AGIDTHEGKRQQKRAEVLE-HLKRLYPDSV 515
++ K+ + + + L R EL N G E KR++ A++ E +K + V
Sbjct: 1208 TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 516 FGRLFDLCHPIHKKYQLAVTKVFGRF---------ITAIVVASEKVAKDCIRFLKEERAE 566
L D K Q+ + V G +T A E +D L+EE +
Sbjct: 1268 RTELADKV----TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ 1323
Query: 567 P---ETFLALDYLDIKPINERLRELKGCK----MVIDVIKTQFPQLKKVIQFVCGNGLVC 619
T L + E+L E + K I + Q +KK ++ G
Sbjct: 1324 KLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG---CL 1380
Query: 620 ETMEEARH------IALSGPERQKTVALDGTLFLKSGVISGGSS-----DLKYKARCWDE 668
ET EE + LS +K A D K+ + D + ++ C E
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 669 KELKNLRD-RRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQN---ELEMIKK 724
K+ K +K K + R E + ++ +T L+ + ELE + K
Sbjct: 1441 KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNK 1500
Query: 725 KHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEI 784
+ F E L S ++ L + + +++++E + +++++ED++ ++
Sbjct: 1501 Q----FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556
Query: 785 GVE-NIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQ 843
+E N++ + + + Q D++ E +KQ R ++E +K+ + ++ ++
Sbjct: 1557 RLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLE 1616
Query: 844 KGSEDID-HLKKAEENCLQTVNELMAKQQQLKDIR---VTQNSSAEKVQTQIEEERKKFL 899
+D++ H+ A +N + + +L Q Q+KD +S E++ Q +E KK
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLK 1676
Query: 900 AVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEA 959
+++ E+ +LQ+E+ + + + Q + E+ L EI SG +E + EA
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELA-------DEIANSSGKGALALEEKRRLEA 1729
Query: 960 ESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAP 1019
Q ++ E++ E+ LK+ LQ DQ I L L E+ +
Sbjct: 1730 RIAQLEEELEEEQGNTELINDRLKK--ANLQIDQ-INTDLNLERSHAQKNENARQQLERQ 1786
Query: 1020 N----LRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRR 1062
N ++ E TV+ K++ S A EA K A+L Q + K+R+
Sbjct: 1787 NKELKVKLQEMEGTVKSKYKASITALEA--KIAQLEEQLDNETKERQ 1831
Score = 101 bits (251), Expect = 5e-21
Identities = 173/914 (18%), Positives = 378/914 (41%), Gaps = 123/914 (13%)
Query: 108 NDNLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGE 167
+D + IAEL K+ + K + VE + +K + E S EL +
Sbjct: 1061 SDQIAELQAQIAEL-KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 168 YEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQ 227
E ++ KAE+ +K+++ E K E E+ + +EL+ +
Sbjct: 1120 LESERASRNKAEK-------QKRDLGEELEALKTELEDTLDSTAAQQELRSKR------- 1165
Query: 228 LYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGM----LTRQLQQTEK- 282
E+++++L LE E HE ++ +++H L QL+QT++
Sbjct: 1166 ----EQEVNILKKTLE----------EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRV 1211
Query: 283 --ELKSVETLLNQKRPQY-------IKAKENTSHHLKKLDVAKKSIK----DSEKQCSKQ 329
L+ + L +R + ++ K ++ H KK++ + ++ + E+ ++
Sbjct: 1212 KANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL 1271
Query: 330 EDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATM 389
D + L+ EL ++ Q + + +D SQL +EL ++ ++ ++
Sbjct: 1272 ADKVTKLQVELDNVTGLL----SQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 390 TQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIE----------KLE 439
+ +L++++ E+ + E+L E+ ++ + + Q+ D KK++E +++
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 440 EYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQK 499
+ ++ L ++ +++ D++EKTK+R+ + ++L L+ + Q E K+Q+K
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL-LVDLDHQRQSACNLE-KKQKK 1445
Query: 500 RAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRF 559
++L K + + + D ++ + TK A+ A E+ A + R
Sbjct: 1446 FDQLLAEEKTI--SAKYAEERDRAEAEAREKE---TKALS-LARALEEAMEQKA-ELERL 1498
Query: 560 LKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVC 619
K+ R E E ++ K ++E + + + ++ +KTQ +L+ +Q L
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558
Query: 620 ETMEEARHIALS---------GPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKE 670
E +A E++K + + AR E +
Sbjct: 1559 EVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD 1618
Query: 671 LKNL----------RDRRSQKIQELKGLMKTLRKETD---LKQIQTLIQGTQTRLKYSQN 717
LK+L RD +++++L+ MK +E D + + L Q + K
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 718 ELEMIKKKHLVAF--------YQEQSQLQSELLN--------------IESQCIMLSEGI 755
E EMI+ + +A QE+ +L E+ N +E++ L E +
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL 1738
Query: 756 KERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKT 815
+E Q + +++ K I Q ++ +E +N++ ++Q E K L+ + Q+
Sbjct: 1739 EEEQGNTELINDRLKKANLQIDQ-INTDLNLERSHAQKNENARQQLERQNKELKVKLQEM 1797
Query: 816 RLNVQLEYSRS--HLKKKLNKI-----NTLKETIQKGSEDIDHLKKAEENCLQTVNELMA 868
V+ +Y S L+ K+ ++ N KE Q + + +K ++ L V++
Sbjct: 1798 EGTVKSKYKASITALEAKIAQLEEQLDNETKER-QAACKQVRRTEKKLKDVLLQVDDERR 1856
Query: 869 KQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHN 928
+Q KD ++ ++++ Q+EE ++ + KLQ+E+ + + E +
Sbjct: 1857 NAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 929 LLLDCKVQDIEIIL 942
L + D+ ++
Sbjct: 1917 LKNKLRRGDLPFVV 1930
Score = 85.5 bits (210), Expect = 3e-16
Identities = 153/816 (18%), Positives = 352/816 (43%), Gaps = 125/816 (15%)
Query: 320 KDSEKQCSKQEDDIKALETELADLD--AAWRSFEKQIEEEILHKKRDIELEASQLDRYKE 377
+ E+ +K+E+ +K E +LA + + + Q+ E L + ++ E +E
Sbjct: 842 RQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEE 901
Query: 378 LKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK 437
L+ ++ K + + L+ + +EER + ++Q N+++++EQ+E+ + +K
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 438 LEEYTKTCMDCLKEKKQQEETLVD-------EIEKTKSRMSEFNEELNLIRSELQNAGID 490
L+ T LK+ ++++ L D E + + R++EF NL E ++ +
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT--TNLTEEEEKSKSLA 1019
Query: 491 THEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASE 550
+ K + ++ E L+R +K + + K + S+
Sbjct: 1020 KLKNKHEAMITDLEERLRR-----------------EEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 551 KVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMV----IDVIKTQFPQLK 606
++A+ L+ + AE + LA +++ R+ E K + I +++Q +L+
Sbjct: 1063 QIAE-----LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 607 KVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCW 666
+ ++ + E + L + + LD T + + S ++ +
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA-AQQELRSKREQEVNILKKTL 1176
Query: 667 DEK------ELKNLRDRRSQKIQEL-KGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNEL 719
+E+ +++ +R + SQ ++EL + L +T R + +L++ + ++ + L NE+
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL---ANEV 1233
Query: 720 EMI---------KKKHLVAFYQE------------------QSQLQSELLNIESQCIMLS 752
+++ K+K + A QE ++LQ EL N+ +LS
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG---LLS 1290
Query: 753 EGIKERQRRIKEF-------QEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQ 805
+ + + K+F Q+ + ++++ Q ++ + + +N ++ +E ++
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350
Query: 806 KRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNE 865
+ EKQ L+ Q+ + ++ + + T +E +K +D++ L + E + ++
Sbjct: 1351 AKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK 1410
Query: 866 L----MAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQ 921
L QQ+L D+ V + + +E+++KKF D+ + +++ +S + + E+
Sbjct: 1411 LEKTKTRLQQELDDLLVDLDHQRQSA-CNLEKKQKKF---DQLLA--EEKTISAKYAEER 1464
Query: 922 KRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSS 981
R E + + ++ + + L+ +L++ +E + E + Q ++ D S
Sbjct: 1465 DRAE-----AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME--------DLMS 1511
Query: 982 LKEDLKALQSDQEIEAHLRLLLQQVASQ-------EDILLKTAAPNLRALENLKTVRDKF 1034
K+D+ +S E+E R L QQV ED L T LR NL+ ++ +F
Sbjct: 1512 SKDDVG--KSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF 1569
Query: 1035 QESTDA--FEASRKEARLCRQ------EFEQVKKRR 1062
+ ++ K+ +L RQ E E +K+R
Sbjct: 1570 ERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 111 bits (278), Expect = 4e-24
Identities = 233/1128 (20%), Positives = 469/1128 (41%), Gaps = 250/1128 (22%)
Query: 1 MAHLELLLVENFKSW----RGRQVIGPFRRFTCIIGPNGSGKSNVMDALSFVMGEKIANL 56
M+ +E + + +S+ + +Q+I F T ++GPNG+GK+ +++ L ++
Sbjct: 1 MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPG 60
Query: 57 RVKNIQELIHGAHIGKPISSSASVKIIYVEESGE--------------EKTFARIIRGGC 102
N +H + + A +++ + + +GE +KT + + G
Sbjct: 61 TKGN--TFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQKSKKTEFKTLEGVI 118
Query: 103 SEFRFNDNLVSRSVYIAELEK-----IGIIVKAQNCLVFQGTVES-ISVKKPKERTQFFE 156
+ + + VS S AE+++ +G+ N ++F +S + + K Q F+
Sbjct: 119 TRTKHGEK-VSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFD 177
Query: 157 EI-----------------STSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQA 199
EI T G+ + EY+ + + L++ +E A + I ++ Q
Sbjct: 178 EIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKA---CEIRDQITSKEAQL 234
Query: 200 KLEKEEAERYQSLLEELK--MNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLS 257
KE + Y++ L+ LK + +I+ L ++ + +I L+++ + + +D S E +
Sbjct: 235 TSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKME 294
Query: 258 ---------------HHENIVKARKKEHGMLTRQLQQTEKELKSV-----ETLLNQKRPQ 297
+H+ V+ ++++ R+L++ KE + + E L+ Q R Q
Sbjct: 295 KVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQ 354
Query: 298 --------YIKAKENTSHHLK---KLD------VAKKSIKDSEKQC-SKQEDDIKALETE 339
+I+A+++ L +LD +++ IK+ K +QE + K
Sbjct: 355 LQADRHQEHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQL 414
Query: 340 LADLDAAWRSFEKQIEE----------------EILHKK----RDIELEASQL----DRY 375
+ D +KQI+E EIL KK ++++ E QL DR
Sbjct: 415 MNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRI 474
Query: 376 KELKEQVRK------------KVATMTQQLEKLQWE--------QKTDEERLAFEKRRHG 415
EL +++ K V T+ ++ LQ E +K D+E + H
Sbjct: 475 LELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQE--MEQLNHHT 532
Query: 416 EVQGNLKQIKEQIEDHKKRIEKLE----EYTKTCMDCLKEKKQQEETL---VDEIEKTKS 468
+ ++ + + D ++I K++ + + + KKQ E+ L EI +T+
Sbjct: 533 TTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRD 592
Query: 469 RMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLC----- 523
R+++ N+EL S QN +E KR++++ E +LFD+C
Sbjct: 593 RLAKLNKEL---ASSEQNKNHINNELKRKEEQLSSYE-----------DKLFDVCGSQDF 638
Query: 524 --------HPIHKKYQ-----LAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETF 570
I K + T V+ +FIT + ++ C R + E E
Sbjct: 639 ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVI 698
Query: 571 --------LALDYL-----DIKPINERLRELKGC----KMVIDVIKTQFPQLKKVIQFVC 613
LA D L ++K +R E+ G + +ID+ + + P+L+ +Q V
Sbjct: 699 SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNV- 757
Query: 614 GNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKN 673
R I + ++ L GT+ + +D+ R + ELK+
Sbjct: 758 -----------NRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERF--QMELKD 804
Query: 674 LRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQE 733
+ + +Q+ +L+G + + ++Q+ Q Q +L +++E+ +K L+ QE
Sbjct: 805 VERKIAQQAAKLQG----IDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRK--LIQDQQE 858
Query: 734 Q--------SQLQSELLNI----------ESQCIMLSEGIKERQRRIKEFQEKIDKVEDD 775
Q ++L+SE L I E Q + LS ++ R IK+ +E++ +E
Sbjct: 859 QIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETT 918
Query: 776 IFQHFCEEIGVENIREFENKHVK-RQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNK 834
+ + E+ + N + NK + + +I +K + ++ + KK+ K
Sbjct: 919 LEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQ--K 976
Query: 835 INTLKETIQKGSEDIDHLKKAEEN---CLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQI 891
L + I + SE H +K E+ Q ++ +++ L+D +T E+++ ++
Sbjct: 977 ETELNKVIAQLSECEKHKEKINEDMRLMRQDIDTQKIQERWLQD-NLTLRKRNEELK-EV 1034
Query: 892 EEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEK--------HNLLL 931
EEERK+ L +E+G++Q +Q E ++LE+ HNL L
Sbjct: 1035 EEERKQHL---KEMGQMQ----VLQMKSEHQKLEENIDNIKRNHNLAL 1075
Score = 60.5 bits (145), Expect = 1e-08
Identities = 157/788 (19%), Positives = 329/788 (41%), Gaps = 91/788 (11%)
Query: 334 KALETELADLDAAWRSFE-----KQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVAT 388
KAL+ + ++ +A R + +Q+ + K ++ ++E L +YKE ++R ++ +
Sbjct: 170 KALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITS 229
Query: 389 MTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE------QIEDHKKRIEK----L 438
QL + K+ E L K R E++ NL +I + ++ KK++EK L
Sbjct: 230 KEAQLTSSKEIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSEL 289
Query: 439 EEYTKTCMDCLKEK------------KQQEETLVD---EIEKTKSRMSEFNEELN--LIR 481
EE + E+ +++E LVD E+EK N+E + L+
Sbjct: 290 EEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVE 349
Query: 482 SELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRF 541
D H+ + + R +++ L F R I ++L + G
Sbjct: 350 QGRLQLQADRHQ-EHIRARDSLIQSLATQLELDGFERGPFSERQIKNFHKLVRERQEGEA 408
Query: 542 ITAIVVASEKVAKDCIRFLK-EERAEPETFLA-LDYLDIKPINERLRELKGCKMVIDVIK 599
TA + ++ K+ ++ + +E + +T L + L + ++++ ELK K + ++
Sbjct: 409 KTANQLMNDFAEKETLKQKQIDEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLE 468
Query: 600 TQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDL 659
++ ++ Q E ++ R LS E+ V TL ++ + +DL
Sbjct: 469 GSSDRILELDQ---------ELIKAERE--LSKAEKNSNVE---TLKMEVISLQNEKADL 514
Query: 660 KYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLK-YSQNE 718
R D+ E++ L + + Q K+ +++I++ T L Y N+
Sbjct: 515 DRTLRKLDQ-EMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLLGYFPNK 573
Query: 719 LEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIF- 777
++ H + +E +Q + L + + + +K +E++ ED +F
Sbjct: 574 KQLEDWLHSKS--KEINQTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFD 631
Query: 778 ----QHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLN 833
Q F E ++ ++E K K++ + + + T+L + + ++
Sbjct: 632 VCGSQDF--ESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQ 689
Query: 834 KINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQ---QLKDIRVTQNSSAEKVQTQ 890
L+E I S+ L+ A + T +EL K++ ++ + + S + + +
Sbjct: 690 TEAELQEVI---SDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKE 746
Query: 891 IEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDI 950
I E R K V+R++ +L+ ++ +T L E+ + KV ++ ++ ++
Sbjct: 747 IPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEES----AKVCLTDVTIMERFQMEL 802
Query: 951 IEVE----------MGTEAESTQATIDIYEKEEAFEIDYSSLKEDL--KALQSDQEIEAH 998
+VE G + + T ++ ++E+ ++D S K +L K +Q QE H
Sbjct: 803 KDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQH 862
Query: 999 LRLLLQQVASQEDILLKTAAPNLRALE----NLKT-VRDKFQESTDAFE-ASRKEARLCR 1052
L+ ++ S E + + T + LE L T V+ ++E DA E S E L
Sbjct: 863 LKSTTNELKS-EKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTL-- 919
Query: 1053 QEFEQVKK 1060
++F+Q K+
Sbjct: 920 EKFQQEKE 927
Score = 60.1 bits (144), Expect = 1e-08
Identities = 62/291 (21%), Positives = 126/291 (43%), Gaps = 47/291 (16%)
Query: 167 EYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQ-- 224
E +EK+ KL + N R+ + ++E+ + +S ELK K+Q+
Sbjct: 831 EKQEKQHKLDTVSSKIELN----------RKLIQDQQEQIQHLKSTTNELKSEKLQISTN 880
Query: 225 LFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEK-- 282
L + E++ L+T+++ + R++ +E +S E ++ ++E L + + K
Sbjct: 881 LQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIA 940
Query: 283 ----------------ELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQC 326
+K +E + + Y K KE +L+ + + EK
Sbjct: 941 QDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKET------ELNKVIAQLSECEKHK 994
Query: 327 SKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKV 386
K +D++ + D+D + E+ +++ + +KR+ EL+ + +R + LKE + +V
Sbjct: 995 EKINEDMRLMRQ---DIDTQ-KIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQV 1050
Query: 387 ATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK 437
M + +KL EE + KR H G K +E+I KK + +
Sbjct: 1051 LQMKSEHQKL-------EENIDNIKRNHNLALGRQKGYEEEIIHFKKELRE 1094
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 109 bits (272), Expect = 2e-23
Identities = 178/919 (19%), Positives = 391/919 (42%), Gaps = 120/919 (13%)
Query: 165 IGEYEEKKRKLQKAEEDAQFNFNKKKN---IAAERRQAKLEKEEAER-YQSLLEELKMNK 220
+ E+ + ++ + E+ Q +KK+ + A +RQ++ E EE LL+E K +
Sbjct: 1315 VPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLE 1374
Query: 221 IQLQLFQ--LYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQ 278
+++ + +++ ++ +E + +L +++ SL HHE+IV E + + L
Sbjct: 1375 CEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEK-SLKHHEDIVD----EIECIEKTLL 1429
Query: 279 QTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALET 338
+ EL+ + LL + + KE T + ++K AK+S+ +E + E +
Sbjct: 1430 KRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAV 1489
Query: 339 ELADLDAAWRSFEKQIEEEILHKKRDIEL--EASQLDRYKELKEQ-VRKKVATMTQQLEK 395
L D RS + ++ HK + E+ E +++ K+ Q + KK +T++L+K
Sbjct: 1490 NLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQK 1549
Query: 396 LQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQ 455
LQ D E + H +V LK+ + ++ + +EKL+ + +QQ
Sbjct: 1550 LQ----KDIEMAERNEDHHLQV---LKESEVLLQAKRAELEKLKSQVTS--------QQQ 1594
Query: 456 EETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKR-----QQKRAEVLEHLKRL 510
E ++D ++ EEL+L++ + A D E R ++ + +K L
Sbjct: 1595 EMAVLDR------QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSL 1648
Query: 511 YPDSVF--GRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPE 568
+ F G L Q++ K I + E+ + +R + + + E +
Sbjct: 1649 LEELSFQKGEL---------NVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELK 1699
Query: 569 TFLALDYLDIKPI-------NERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCET 621
L + L+ + ++R+ EL+ ++ + K + L+++ Q G E
Sbjct: 1700 NILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKG-----EI 1754
Query: 622 MEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEK------------ 669
+ + + E ++ A L +S DL+ K W++K
Sbjct: 1755 EWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAE 1814
Query: 670 ELKNLRDRRSQKI--------QELKGLMK-TLRKETDLKQIQTLIQGTQTRLKYSQNELE 720
E + +K+ QEL L + L D+ +Q +Q + + Q EL
Sbjct: 1815 ENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELA 1874
Query: 721 MIK------KKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVED 774
++ K+ L+ + Q L SE ++ + ++ Q+ + Q+++ +++
Sbjct: 1875 NVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQN 1934
Query: 775 DIFQHFCEEIGVENI-REFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLN 833
+I ++ + + E + + + + + +++ ++ ++Q+ +L +L +S L + L+
Sbjct: 1935 EIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLS 1994
Query: 834 KINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIR---VTQNSSAEKVQTQ 890
K+ +E ++ E+ + E+ QT +L ++QQL + + A+ ++
Sbjct: 1995 KVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRAD 2054
Query: 891 IEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDI 950
R +FL E K +K+V S++ +L+ +R + LL+ K + +
Sbjct: 2055 FSLLRNQFLT---ERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE-----------NSC 2100
Query: 951 IEVEMGT----EAESTQATIDIYEKEEAFEIDYSSLKEDL---KALQSDQ-EIEAHLRLL 1002
I+ EM T ++ + + ++ + +Y+ LK+ + K L+ Q EI +R L
Sbjct: 2101 IQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTL 2160
Query: 1003 LQQVASQEDILLKTAAPNL 1021
+V + ++T+ NL
Sbjct: 2161 KSEVKDE----IRTSLKNL 2175
Score = 80.5 bits (197), Expect = 9e-15
Identities = 151/738 (20%), Positives = 315/738 (42%), Gaps = 101/738 (13%)
Query: 163 ELIGEYEEKKRKLQKAE--EDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNK 220
+L E ++ ++ ++ AE ED K+ + + ++A+LEK +++ E +++
Sbjct: 1542 KLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDR 1601
Query: 221 IQLQLFQLYHNEKKIHLLNTKLEHVNRDLS-------VKRESLSHHENIVKARKKEHGML 273
QL H ++++HLL + DL + +H VK+ +E
Sbjct: 1602 ------QLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQ 1655
Query: 274 TRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKD---------SEK 324
+L E K+ TL+ Q + K +EN L+++ K +K+ E
Sbjct: 1656 KGELNVQISERKTQLTLIKQ---EIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHEL 1712
Query: 325 QCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKR-DIELEASQLDRYKELKEQVR 383
Q K + D + E E + E + ++I +++ +IE + L+R K E++
Sbjct: 1713 QGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMT 1772
Query: 384 KKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTK 443
+ + +E L E++ +E+ +++ + + L +E + + +EKLE +
Sbjct: 1773 AESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR 1832
Query: 444 TCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQ-----Q 498
L + + + +L ++I + ++ E E +N ++ EL N + K+ +
Sbjct: 1833 KLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTK 1892
Query: 499 KRAEVLEHLKRLYPD-SVFGRLFDLCHPIH--KKYQLAVTKVFGRFITAIVVASEKVAKD 555
+ +L RL D S + F+ C K+ QL V + I K+ +
Sbjct: 1893 HQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQ------NEIEENKLKLVQQ 1946
Query: 556 CIRF--LKEERAEPETFLALDYLDIKPINERL-RELKGCKMVIDVIKTQFPQLKKVIQFV 612
+ F L++ER E+ L + +K +L +EL K +D + ++ ++ ++ +
Sbjct: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTL 2006
Query: 613 CGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELK 672
CE++E+ LS +RQ + + L KSG + L+
Sbjct: 2007 QEEERWCESLEK----TLSQTKRQLS-EREQQLVEKSGELLA----------------LQ 2045
Query: 673 NLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQ 732
D L+ T RK+ + KQ+ +L + LK +++LE K+L+ Q
Sbjct: 2046 KEADSMRADFSLLRNQFLTERKKAE-KQVASL----KEALKIQRSQLE----KNLLEQKQ 2096
Query: 733 EQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREF 792
E S +Q E+ IE ++++ ER RR+ + E + Q+ E+
Sbjct: 2097 ENSCIQKEMATIE----LVAQDNHERARRLMK--------ELNQMQYEYTEL-------- 2136
Query: 793 ENKHVKRQQEIDQKRLEFEKQ----KTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSED 848
K + Q++++++++E K+ + ++ S +L + L ++ E I + +E+
Sbjct: 2137 -KKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNEN 2195
Query: 849 ID-HLKKAEENCLQTVNE 865
++ L+ +EN T+NE
Sbjct: 2196 LEGELESLKENLPFTMNE 2213
Score = 65.1 bits (157), Expect = 4e-10
Identities = 87/447 (19%), Positives = 186/447 (41%), Gaps = 71/447 (15%)
Query: 668 EKELKNLRDRRSQKIQEL-KGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKH 726
EK++ + R S+ E+ K + LR + KQ++ IQ LK + + K
Sbjct: 443 EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ-----LKKISEAGKDLLYKQ 497
Query: 727 LVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGV 786
L Q ++L+ E L++E Q + I +Q+ IK+ Q ID ++
Sbjct: 498 LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS------------ 545
Query: 787 ENIREFENKHVKRQQEIDQKRLEF-EKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKG 845
++ ++ H+K Q+ +++L+ KQ +L +L+ S + K+ +I L+E + +G
Sbjct: 546 ---KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG 602
Query: 846 SEDIDH-LKKAEENCLQTVNELMAK--------QQQLKDIRVTQNSSAEKVQTQIEEERK 896
+ LKK E + + E + Q + + +R + + +++ T++E+ER
Sbjct: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRL-TEVEQERD 661
Query: 897 KFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMG 956
+ V + ++KE+ ++++L+++ E+
Sbjct: 662 QLEIVAMDAENMRKELAELESALQEQH------------------------------EVN 691
Query: 957 TEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKT 1016
+ TQ + YE E ++ D +A Q +E+E RL + ++ + L K
Sbjct: 692 ASLQQTQGDLSAYEAELEARLNL----RDAEANQLKEELEKVTRLTQLEQSALQAELEKE 747
Query: 1017 AAPNLRALENLKTVRDKFQESTD---AFEASRKEARLCRQEFEQVKKRRYDLFTQCF--E 1071
AL + +K QE+++ + + + L +Q+ + + + E
Sbjct: 748 RQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPE 807
Query: 1072 HVSISIDQIYKKLCRNNSAQAFLSPEN 1098
V+ +D++ +KL SP +
Sbjct: 808 EVAARVDELRRKLKLGTGEMNIHSPSD 834
Score = 63.5 bits (153), Expect = 1e-09
Identities = 176/914 (19%), Positives = 359/914 (39%), Gaps = 148/914 (16%)
Query: 150 ERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAER---------RQAK 200
++T+F EEI +L +E+ +++ E+ + + N K + ++ +Q +
Sbjct: 292 KQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYE 351
Query: 201 LEKEEA-----ERYQSL----LEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSV 251
LE+E A +++ L E +++K + + + K ++ T+ ++ +V
Sbjct: 352 LEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAV 411
Query: 252 KRESLSHHENIVKARK--KEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKE------ 303
+ + + E + + H L QL+ EK++ + +T L++ + KA++
Sbjct: 412 QIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRAT 471
Query: 304 ------NTSHHLKKLDVAKKSI-------------------KDSEKQCSKQEDDIKALET 338
+ LKK+ A K + D E Q KQ+ +I +
Sbjct: 472 EEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQK 531
Query: 339 ELADLDAAWRSFEKQIEEEILHKKRDIELEASQLD----RYKELK---EQVRKKVATMTQ 391
E+ DL A S + + + + H K + QLD +Y++L+ +++ ++A T+
Sbjct: 532 EIKDLQIAIDSLDSK-DPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE 590
Query: 392 QLEKLQWEQKTDEE---RLAFEKRRHGEVQG---NLKQIKEQIEDHKKRIEKLEEYTKTC 445
+++ L+ EQ T+ + A +K G + G L IK Q + KL + +T
Sbjct: 591 EIKDLE-EQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETL 649
Query: 446 MDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQ-----NAGIDTHEGKRQQKR 500
+ L E +Q+ D++E +EL + S LQ NA + +G
Sbjct: 650 LQRLTEVEQER----DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYE 705
Query: 501 AEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFL 560
AE+ L D+ +L + + + QL + + + K +F
Sbjct: 706 AELEARLN--LRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGK--AQFS 761
Query: 561 KEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCE 620
+E+ E +E +LK + +++K Q + + V +GLV
Sbjct: 762 EEKEQEN--------------SELHAKLKHLQDDNNLLKQQLKDFQNHLNHVV-DGLVRP 806
Query: 621 TMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYK-----ARCWDEKELKNLR 675
AR L + K + + S V+ +DL+ + AR E++ +R
Sbjct: 807 EEVAARVDELR--RKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
Query: 676 DRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYS--QNELEMIKKKHLVAFYQE 733
+R K+QE L + + Q + + R+ + Q+E + + ++ + + QE
Sbjct: 865 ER---KLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQE 921
Query: 734 QSQLQSELLNIESQCIMLSEGIKERQRRIKEFQ--EKIDKVEDDIFQHFCEEIGVENIRE 791
+ E+ + + L E +E++R + + + EK K+ED
Sbjct: 922 NLKSMEEIQGLTD--LQLQEADEEKERILAQLRELEKKKKLED----------------- 962
Query: 792 FENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDH 851
K Q+++ E +K K + + + + L +++ +L T+ K +++
Sbjct: 963 -----AKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQE--- 1014
Query: 852 LKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKE 911
+AEE LQ K Q + E +Q + ++ ++F +L+ E
Sbjct: 1015 --RAEE--LQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQF--------RLEME 1062
Query: 912 VVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEK 971
+ T + LE L + Q EI L L D+ + E+ I +
Sbjct: 1063 KTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVL-DLTGSDNKGGFENVLEEIAELRR 1121
Query: 972 EEAFEIDYSSLKED 985
E +++ DY S D
Sbjct: 1122 EVSYQNDYISSMAD 1135
Score = 44.7 bits (104), Expect = 6e-04
Identities = 67/347 (19%), Positives = 144/347 (41%), Gaps = 36/347 (10%)
Query: 198 QAKLEKEEAE-RYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKL-----EHVNRDLSV 251
++K E++EA+ R + L EE+ + + +L Q + L ++ +H R +
Sbjct: 853 RSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQM 912
Query: 252 KRESLSHHENIVKARKKEHGMLTRQLQQTEKE----LKSVETLLNQKRPQYIKAKENTSH 307
+ E EN+ K+ ++ G+ QLQ+ ++E L + L +K+ + K++E
Sbjct: 913 ENEIHYLQENL-KSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFG 971
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIEL 367
K+L KK++ S+K + ++ + +L L ++ EE+
Sbjct: 972 LDKELKKLKKAVATSDKLATA---ELTIAKDQLKSLHGTVMKINQERAEEL--------- 1019
Query: 368 EASQLDRYKELKEQVRKKVATMTQQLEKLQ--WEQKTDEERLAFEKRRHGEVQGN----L 421
+ +R+ Q + + ++E LQ QK ++ RL EK G + +
Sbjct: 1020 --QEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEI 1077
Query: 422 KQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIR 481
+++ E +E + I +L+ + K E +++EI + + +S N+ ++ +
Sbjct: 1078 EKLNETMERQRTEIARLQNVLDLTG---SDNKGGFENVLEEIAELRREVSYQNDYISSMA 1134
Query: 482 SELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHK 528
+ G ++V H + DS G + P+ K
Sbjct: 1135 DPFKRRGY--WYFMPPPPSSKVSSHSSQATKDSGVGLKYSASTPVRK 1179
Score = 37.0 bits (84), Expect = 0.12
Identities = 57/309 (18%), Positives = 123/309 (39%), Gaps = 50/309 (16%)
Query: 156 EEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKE---EAERYQSL 212
EE++ E + +E+ R+ + +A+ NF+K+++ E R ++E E E +S+
Sbjct: 870 EEMALQQEKLATGQEEFRQACERALEARMNFDKRQH---EARIQQMENEIHYLQENLKSM 926
Query: 213 LEELKMNKIQLQ---------LFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIV 263
E + +QLQ L QL EKK L + K + L + + L
Sbjct: 927 EEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLK------ 980
Query: 264 KARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSE 323
KA + T +L + +LKS+ + +K + + L++ + + +
Sbjct: 981 KAVATSDKLATAELTIAKDQLKSLHGTV-------MKINQERAEELQEAERFSRKAAQAA 1033
Query: 324 KQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVR 383
+ ++ E +I+ L+ L +R +E E + ++++ E E+ R
Sbjct: 1034 RDLTRAEAEIELLQNLLRQKGEQFR-----LEMEKTGVGTGANSQVLEIEKLNETMERQR 1088
Query: 384 KKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTK 443
++A + L+ + K G + + E+I + ++ + +Y
Sbjct: 1089 TEIARLQNVLDLTGSDNK-----------------GGFENVLEEIAELRREVSYQNDYIS 1131
Query: 444 TCMDCLKEK 452
+ D K +
Sbjct: 1132 SMADPFKRR 1140
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 106 bits (265), Expect = 1e-22
Identities = 200/999 (20%), Positives = 420/999 (42%), Gaps = 154/999 (15%)
Query: 150 ERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKN----IAAERRQAKLEKEE 205
E + ++I E I EE+K QK +E +Q N+K I+ + + K+ +EE
Sbjct: 1834 EINNYLQQIDQLKERIAGLEEEK---QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEE 1890
Query: 206 AERYQSLLEELKMNKIQLQLFQLYHNEKKIHL---LNTKLEHVN----------RDLSVK 252
+ L ++++ ++ + E+K L L +L +N D +K
Sbjct: 1891 VTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIK 1950
Query: 253 RESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKE----NTSHH 308
E L E+ +K KK L + QQ KE VE+ + ++ + I+ + N SH
Sbjct: 1951 NELL---ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Query: 309 LKKLDVAKKS---IKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIE-------EEI 358
+ ++ K+ +K +K C + ++ I ALE + L+ +K +E + +
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 359 LHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFE-KRRHGEV 417
H+K+ ++L +K L + + + A + KL+ E ++++E + + K++ ++
Sbjct: 2068 EHRKK----AQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDL 2123
Query: 418 QGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEEL 477
+ L+Q +E+ KK +++ +D L+ +K E + EI+ T ++ + ++L
Sbjct: 2124 ERRLEQAEEKHLKEKKNMQEK-------LDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 478 --NLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVT 535
NL + Q A Q R V++ K
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAK--------------------------- 2209
Query: 536 KVFGRFITAIVVASEKVA--KDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKM 593
K +F AI E++ +D LK++ + +++ ++K RL K ++
Sbjct: 2210 KWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ----MSIHMEELKINISRLEHDK--QI 2263
Query: 594 VIDVIKTQFPQLKKVIQFVCG-NGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVI 652
+T+ +KV + G N + +EE RH+ S + + L+ L +
Sbjct: 2264 WESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS--QNELAKLESELKSLKDQL 2321
Query: 653 SGGSSDLKYKARCWDEK------------ELKNLR---DRRSQKIQELKGLMKTLRKETD 697
+ S+ L+ +C ++K +++N + ++ +Q + L L +E +
Sbjct: 2322 TDLSNSLE---KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEIN 2378
Query: 698 LKQ--IQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGI 755
+K+ I +L+ G + ++ + EL K + +L++ L E + I+L E
Sbjct: 2379 MKEQKIISLLSGKEEAIQVAIAELRQQHDKEI-------KELENLLSQEEEENIVLEEEN 2431
Query: 756 KERQRRIKEFQEKIDKVEDDIFQHFCE-EIGVENIREFENKH---VKRQQEIDQKRLEFE 811
K+ + + E + ++ + Q + + V+++ +N V Q+++++ L
Sbjct: 2432 KKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSII 2491
Query: 812 KQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDID-HLKKAEENCLQTVNELMAKQ 870
+K +L + + LK+++ + + + + + +D L + E+ Q + ++Q
Sbjct: 2492 LEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQ 2551
Query: 871 QQLKDIRVTQNSSAEKVQTQIEEE-----------RKKFLAVDREVGKLQKEVVSIQTSL 919
+QL ++++ QN E ++EE+ R+ F A+ E L KE+ S++ S+
Sbjct: 2552 KQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSI 2611
Query: 920 EQ-----KRLEKHNLL----LDCKVQDIEI----ILLSGSLDDIIEVEMGTEAESTQATI 966
Q L++ L KV++ E+ L S S I E+E +A
Sbjct: 2612 SQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAK 2671
Query: 967 DIYEKEEAFEIDYSSLKEDLKALQSDQE-IEAHLRLLLQQVASQEDILLKTAAPNLRALE 1025
+ E E+ + + L D ++++ E E + L + + E LL N +
Sbjct: 2672 KVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKEN----K 2727
Query: 1026 NLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYD 1064
L F S + + SR A +E +++ KR+YD
Sbjct: 2728 GLTAQIQSFGRSMSSLQNSRDHA---NEELDEL-KRKYD 2762
Score = 101 bits (251), Expect = 5e-21
Identities = 181/966 (18%), Positives = 403/966 (41%), Gaps = 156/966 (16%)
Query: 169 EEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLE-KEEAERYQ----------------- 210
+E +++LQ+AE++ + K + A ++Q LE +EE +R +
Sbjct: 1658 KETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717
Query: 211 -----SLLEELKMNKIQLQL----FQLYHNEK-----KIHLLNTKLEHVNRDLSVKRESL 256
S+ EEL+ K++ + FQ +EK ++ L ++E N E+
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEG-NVSKQANLEAT 1776
Query: 257 SHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKA-----KENTSH---- 307
H+N ++ + + ++ + S ++ P A K+ +SH
Sbjct: 1777 EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEIN 1836
Query: 308 -HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIE 366
+L+++D K+ I E++ K ++ + LE E + + +I K +++
Sbjct: 1837 NYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE-----------KNTLLSQISTKDGELK 1885
Query: 367 LEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
+ ++ + L +Q++++++ +T+ E + E+ EERL + E+ G++ +
Sbjct: 1886 MLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLM---NQLAELNGSIGNYCQ 1942
Query: 427 QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQN 486
+ D + + E LE K C+ E +++++ LV E K +S + + E L I+ +
Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRK--EYLEKIQGAQKE 2000
Query: 487 AGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIV 546
G +H + Q+ E + +K+L D + +YQ ++ + R + A+
Sbjct: 2001 PGNKSHAKELQELLKEKQQEVKQLQKDCI-------------RYQEKISAL-ERTVKALE 2046
Query: 547 VASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLK 606
+ KD + KE A+ ++ + EL K+++D +++ +
Sbjct: 2047 FVQTESQKD-LEITKENLAQA----------VEHRKKAQAELASFKVLLDDTQSEAAR-- 2093
Query: 607 KVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCW 666
V + L + ++ ++ +QK L+ L LK K
Sbjct: 2094 -----VLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE------QAEEKHLKEKKNM- 2141
Query: 667 DEKELKNLRDRRSQKIQELKGLMKTL-RKETDLKQIQTLIQGTQTRLKYSQNELEMIK-- 723
+++L LR + + + + TL +K+ +++Q+Q + T T+L + ++
Sbjct: 2142 -QEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
Query: 724 --------KKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDD 775
KK F + E+ E C +L + +++ ++E + I ++E D
Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHD 2260
Query: 776 IFQHFCEEIGVENIREFENKHVKRQQEIDQKRLE-FEKQKTRLNVQLEYSRSHLKKKLNK 834
++ + + ++ QK + + + L QLE +R N+
Sbjct: 2261 --------------KQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNE 2306
Query: 835 INTLKETIQKGSEDIDHLKKAEENCLQTVNELMAK-QQQLKDIRVTQNS--SAEKVQTQI 891
+ L+ ++ + + L + E C + L +QQ DI QNS S E+++T +
Sbjct: 2307 LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADI---QNSKFSYEQLETDL 2363
Query: 892 EEERKKFLAVDREVGKLQKEVVSIQTSLE---QKRLEKHNLLLDCKVQDIEIILLSGSLD 948
+ R+ + E+ +++++S+ + E Q + + D +++++E +L +
Sbjct: 2364 QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE 2423
Query: 949 DIIEVEMGTEA----ESTQATIDIYEKE--------EAFEIDYSSLKEDLKALQSD--QE 994
+I+ E +A T+ +KE ++F SSL+ D + D Q
Sbjct: 2424 NIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQL 2483
Query: 995 IEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLC--R 1052
E HL ++L+ ++ ++ + AA N + E ++ +R + E ++ +A L R
Sbjct: 2484 EERHLSIILE----KDQLIQEAAAENNKLKEEIRGLRSHMDDLNS--ENAKLDAELIQYR 2537
Query: 1053 QEFEQV 1058
++ QV
Sbjct: 2538 EDLNQV 2543
Score = 92.8 bits (229), Expect = 2e-18
Identities = 185/995 (18%), Positives = 420/995 (42%), Gaps = 100/995 (10%)
Query: 140 VESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQA 199
+E+ V+ + + E++ E + + +E+ K Q E ++ + + + AE Q
Sbjct: 1314 IEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK-QGLEIESLKTVSHEAEVHAESLQQ 1372
Query: 200 KLEKEEAERYQSLLEELKMNKIQLQLFQ--LYHNEKKIHLLNTKLEHVNRDLSVKRESLS 257
KLE + + + LE L+ + +L Q + E+ + L+ +L L+ + +
Sbjct: 1373 KLESSQLQI--AGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEII 1430
Query: 258 HHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHL-KKLDVAK 316
E+++KA + M ++ + K+L+ VE +++P+ I + + +KL A
Sbjct: 1431 EQEDLIKALHTQLEMQAKEHDERIKQLQ-VELCEMKQKPEEIGEESRAKQQIQRKLQAAL 1489
Query: 317 KSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYK 376
S K++ K+ ++++ + L + E Q+ + +K++D + L R
Sbjct: 1490 ISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQ--NKEKD-----TVLGRLA 1542
Query: 377 ELKEQVRKKVATMTQQL-EKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRI 435
L+E+ K + M + L E + +LA E G + K +KE +I
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALE----GLTEDKEKLVKEIESLKSSKI 1598
Query: 436 EKLEEYTKTCMDCLKEKK---QQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTH 492
+ E+ + + KE + Q E + +E E+ + + +E + +L++ +
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
Query: 493 EGKRQQKRAEV-LEHLK---RLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVA 548
E ++Q + AE +E +K R + S ++ +L + + A V
Sbjct: 1659 ETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDR-------------LRAEVHP 1705
Query: 549 SEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKV 608
+ AK+C+ L A + L ++ + ++++ + L K D + + LK
Sbjct: 1706 AGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEK---DSLSEEVQDLKHQ 1762
Query: 609 IQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDE 668
I+ GN ++A A + Q V +GT + S + + C +
Sbjct: 1763 IE---GN-----VSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSES 1814
Query: 669 -KELKNLRDRRSQKIQELKGLMKTLRKETDLKQ-IQTLIQGTQTRLKYSQNELEMIKKKH 726
K+ S+ + L++ LK+ I L + Q ++SQ LE K
Sbjct: 1815 VPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT-LENEKNTL 1873
Query: 727 LVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQ-------- 778
L + +L+ L ++ +L++ I+E R+ + +E ++ +DD+ +
Sbjct: 1874 LSQISTKDGELKM-LQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAE 1932
Query: 779 ------HFCEEIGVENIR----EFENKHVKR-QQEIDQKRLEFEKQKTRLNVQ-----LE 822
++C+++ I+ E E K++K+ E+++++ + K+KT++ + LE
Sbjct: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
Query: 823 YSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNS 882
+ K+ NK + KE + E +K+ +++C++ ++ A ++ +K + Q
Sbjct: 1993 KIQGAQKEPGNKSHA-KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051
Query: 883 SAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIIL 942
S Q +E ++ K Q E+ S + L+ + E +L D ++++
Sbjct: 2052 S----QKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLAD----NLKLKK 2103
Query: 943 LSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQ--------E 994
S + ++ +M + E + ++ + EE + +++E L AL+ ++ E
Sbjct: 2104 ELQSNKESVKSQMKQKDEDLERRLE--QAEEKHLKEKKNMQEKLDALRREKVHLEETIGE 2161
Query: 995 IEAHLRLL---LQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLC 1051
I+ L +QQ+ D + A +++ +L+ RD+ + +E +A
Sbjct: 2162 IQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS 2221
Query: 1052 RQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCR 1086
++E ++K+ + +SI ++++ + R
Sbjct: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR 2256
Score = 80.9 bits (198), Expect = 7e-15
Identities = 196/1039 (18%), Positives = 415/1039 (39%), Gaps = 152/1039 (14%)
Query: 120 ELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQF-FEEISTSGELIGEYEEKKRKLQKA 178
++ K G+ +++ + + V + S+++ E +Q + EL + +E ++ + K
Sbjct: 1345 QINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKK 1404
Query: 179 EEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLL 238
EED + +L ++EA + KIQ ++ + E I L
Sbjct: 1405 EEDVSY------------LSGQLSEKEAA----------LTKIQTEIIE---QEDLIKAL 1439
Query: 239 NTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQY 298
+T+LE ++ + + L +K + +E G +R QQ +++L++ + +
Sbjct: 1440 HTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN 1499
Query: 299 IKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEI 358
+E S ++ KS+ D E Q S Q + + LA L +++ +
Sbjct: 1500 KSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSL 1559
Query: 359 LHKKR---DIELEASQLDRYKELKEQVRKKVATMTQQ--LEKLQWEQKTDEERLAFE--K 411
L + E L+ E KE++ K++ ++ E +W++K E + +E
Sbjct: 1560 LENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILL 1619
Query: 412 RRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMS 471
+ + V ++I+ +E ++ ++L ++ KE ++Q + E+E+ K +M
Sbjct: 1620 QSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMR 1679
Query: 472 EF-----------NEELNLIRSELQNAGIDTHEGKR-----QQKRAEVLEHLKRLYP--- 512
+F EE + +R+E+ AG E E LE +K Y
Sbjct: 1680 KFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLS 1739
Query: 513 ----------DSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKE 562
DS+ + DL H I V+K T V ++ + +
Sbjct: 1740 KKFQSLMSEKDSLSEEVQDLKHQIEGN----VSKQANLEATEKHDNQTNVTEEGTQSIPG 1795
Query: 563 ERAEPETFLALDYLDIKPI-NERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCET 621
E E ++ + +P +E + K + + ++ +Q + +
Sbjct: 1796 ETEEQDSLS----MSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQI-------DQ 1844
Query: 622 MEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELK-NLRDRRSQ 680
++E IA E+QK TL + + S + + E+ K NL +++ Q
Sbjct: 1845 LKE--RIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQ 1902
Query: 681 ----KIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQ 736
++ +LK + + + + + + L + + Y Q+ + K L
Sbjct: 1903 EELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL--------- 1953
Query: 737 LQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKH 796
L+SE+ N++ +C+ SE +E+Q+ +KE KVE +I + + E+I H
Sbjct: 1954 LESEMKNLK-KCV--SELEEEKQQLVKEKT----KVESEIRKEYLEKIQGAQKEPGNKSH 2006
Query: 797 VKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKG--------SED 848
K QE+ +++ + KQ + ++ + S L++ + + ++ QK ++
Sbjct: 2007 AKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQA 2066
Query: 849 IDHLKKAEENC---------------------LQTVNELMAKQQQLKDIRVTQNSSAEKV 887
++H KKA+ L+ EL + ++ +K ++ E+
Sbjct: 2067 VEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126
Query: 888 QTQIEEE--------RKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLL--LDCKVQD 937
Q EE+ ++K A+ RE L++ + IQ +L +K E L LD V
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 938 I-----EIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSD 992
+ + L D +I+ E + + A E+ E + S LK+ L+ +
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIH 2246
Query: 993 -QEIEAHLRLL-----LQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRK 1046
+E++ ++ L + + +Q ++ L+ + EN K + + +E+ + +S+
Sbjct: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN-KELLSQLEETRHLYHSSQN 2305
Query: 1047 EARLCRQEFEQVKKRRYDL 1065
E E + +K + DL
Sbjct: 2306 ELAKLESELKSLKDQLTDL 2324
Score = 76.6 bits (187), Expect = 1e-13
Identities = 203/1034 (19%), Positives = 405/1034 (39%), Gaps = 184/1034 (17%)
Query: 139 TVESISVKKPKERTQFFEEI----------------STSGELIGEYEEKKRKLQKAEEDA 182
T E + ++K K + Q EE+ + S + E+ K++LQ+ EE
Sbjct: 140 TEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFI 199
Query: 183 QFNFNKKKNIAAERRQAKLEKEEAERYQSL--LEELKMNKIQLQLFQLYHNEKKIHLLNT 240
+ AE+ ++ +E+ R+++ L E ++ ++ Q ++K+ +L
Sbjct: 200 STLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQR 259
Query: 241 KLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKE----------------- 283
KLE L + + + + + A ++ + +L++QLQQ E E
Sbjct: 260 KLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI 319
Query: 284 -LKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKA------- 335
L+ +E + +++ + +E H L++ + A ++ + E + S E KA
Sbjct: 320 LLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTS 379
Query: 336 ----LETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQ 391
L+ +L +A + + Q ++L K + ++++Q ++L++Q+++K ++Q
Sbjct: 380 HILSLQKTGQELQSACDALKDQ-NSKLLQDKNEQAVQSAQ--TIQQLEDQLQQKSKEISQ 436
Query: 392 QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDC--- 448
L +L +Q + +F + +G +E I +KR+ +LE +
Sbjct: 437 FLNRLPLQQHETASQTSFPDVYN---EGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493
Query: 449 LKEKKQQEETLVDEIE--KTKSRMSEFNEELNLI---------RSELQNAGIDTHEGKRQ 497
L+E K + E L +I + ++R E + E++ I S + +G D E
Sbjct: 494 LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553
Query: 498 QKRAE---VLEHLKRLYPDSVF-------GRLFDLCHPIHKKYQLAVTKVFGRFITAIVV 547
QK E +L +K + F R + H + + ++ + G + V
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613
Query: 548 ASEKVAKDCIRFLKEERAEP-------ETFLALDYLDIKPINERLRELKGCKMVIDVIKT 600
E +D EE + P T + +N+ ELK K D +
Sbjct: 614 FLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673
Query: 601 QFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTL-FLKSGVISGGSSDL 659
P + + Q ER K+ L+ L F K+ I + D
Sbjct: 674 AVPDIGQCHQ--------------------DELERLKSQILELELNFHKAQEIYEKNLDE 713
Query: 660 KYKARCWDEKELKNLRDRRSQKIQELK-------GLMKTLRKETD--LKQIQTLIQGTQT 710
K K E+ NL +Q I+E K L +E D L Q++ L T+
Sbjct: 714 KAK-------EISNL----NQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTEL 762
Query: 711 RLKYSQNELEMIKKK---------------------HLVAFYQEQSQLQSELLNIESQCI 749
R + Q E+ + + + H ++ + ++ E+L E +
Sbjct: 763 RAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDV 822
Query: 750 MLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLE 809
L E+ I+ Q ++ E ++ + G E +R +K + Q + QK LE
Sbjct: 823 QLQ--FSEQSTLIRSLQSQLQNKESEVLE------GAERVRHISSKVEELSQALSQKELE 874
Query: 810 FEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLK-KAEENCLQTVNELMA 868
K L L+KK + TL++TI++ + + + E +Q E +
Sbjct: 875 ITKMDQLL----------LEKK-RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923
Query: 869 KQQQLKDIRVTQN--SSAEKV-QTQIEEERKKFLAVDRE------VGKLQKEVVSIQTSL 919
++K ++ N S AE+ + Q+EE+ + + + G++ KE + + L
Sbjct: 924 LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983
Query: 920 EQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEA-FEID 978
+K E+ L + + + +L S +E E+ + ++ I + E E E D
Sbjct: 984 LKKENEQRKRKLQAALINRKELLQRVSR---LEEELANLKDESKKEIPLSETERGEVEED 1040
Query: 979 YSSLKEDLKALQSD-QEIEAHLRLLLQQVASQEDILLKTAAPNLRALEN----LKTVRDK 1033
+ + K + S QEIE +L+ + + + + K L A E +K +
Sbjct: 1041 KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQT 1100
Query: 1034 FQESTDAFEASRKE 1047
Q+ T+ + + E
Sbjct: 1101 LQDKTNQIDLLQAE 1114
Score = 76.6 bits (187), Expect = 1e-13
Identities = 176/936 (18%), Positives = 366/936 (39%), Gaps = 153/936 (16%)
Query: 156 EEISTSGELIG-EYEEKKRKLQKA---------------EEDAQFNFNKKKNIA---AER 196
EE+ +L+ E E++KRKLQ A EE A KK I ER
Sbjct: 975 EELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETER 1034
Query: 197 RQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESL 256
+ + +KE E Y K +I++ L Q +EK++ +L+H+ +DL K +
Sbjct: 1035 GEVEEDKENKE-YSEKCVTSKCQEIEIYLKQTI-SEKEV-----ELQHIRKDLEEKLAAE 1087
Query: 257 SHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKK--LDV 314
+ +VK + T Q+ + E+ + ++ + A + S L K + +
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVI 1147
Query: 315 AKKSIKDSEKQCSKQEDDIKALETELADLD-------AAWRSFEKQIEEEILHKKRDIEL 367
+ SE + E+ I ALE E L + ++ K+ +E+ H + +++
Sbjct: 1148 SPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQ 1207
Query: 368 EASQLDRYKELKEQVRKKVATMTQQLEKLQWEQK---------TDE----------ERLA 408
+ +R +E ++ K+ + QL +LQ + + TD+ E
Sbjct: 1208 QKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPL 1267
Query: 409 FEKRRHGEVQGNLKQ-IKEQIEDHKKRIEKLEEYTKTCM--DCLKEKKQQEETLVDEIEK 465
F+ Q L+ + H + L+ T LKE + ++ L ++
Sbjct: 1268 FKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSS 1327
Query: 466 TKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEV------------------LEHL 507
T S +++ +EE+ ++ ++ G++ K AEV LEHL
Sbjct: 1328 TTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHL 1387
Query: 508 KRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEP 567
+ L P +L +L I KK + V+ + G+ SEK A + ++ E E
Sbjct: 1388 RELQP-----KLDELQKLISKKEE-DVSYLSGQL-------SEKEA--ALTKIQTEIIEQ 1432
Query: 568 ETFLALDY----LDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETME 623
E + + + K +ER+++L + + ++K+ + + + ++
Sbjct: 1433 EDLIKALHTQLEMQAKEHDERIKQL----------QVELCEMKQKPEEIGEESRAKQQIQ 1482
Query: 624 EARHIALSGPER--QKTVALDGTLFLKSGVI---SGGSSDLKYKARCWDEKE------LK 672
AL + ++ +L L L G I + +D++ + ++++ L
Sbjct: 1483 RKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLA 1542
Query: 673 NLRDRRSQKIQEL-KGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFY 731
L++ R + I E+ + L++ + + ++ ++G + E+E +K +A
Sbjct: 1543 LLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSK-IAES 1601
Query: 732 QEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIRE 791
E + EL + E + RI+ E + + + +++ +R
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELY---------GKLRS 1652
Query: 792 FENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDH 851
E + ++++ + E E+ K ++ R K K KI L+E + ++
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKM-------RKFAKSKQQKILELEEENDRLRAEVHP 1705
Query: 852 LKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKE 911
+ C++T L++ +K+ E+V+ + E KKF ++ E L +E
Sbjct: 1706 AGDTAKECMET---LLSSNASMKE-------ELERVKMEYETLSKKFQSLMSEKDSLSEE 1755
Query: 912 VVSIQTSLE--------QKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQ 963
V ++ +E + EKH+ + + + I G ++ + M T ++
Sbjct: 1756 VQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI--PGETEEQDSLSMSTRPTCSE 1813
Query: 964 ATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHL 999
+ A D+SS E LQ +++ +
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERI 1849
Score = 73.9 bits (180), Expect = 9e-13
Identities = 183/976 (18%), Positives = 404/976 (41%), Gaps = 117/976 (11%)
Query: 149 KERTQFF---EEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKK-------------NI 192
+ER Q +E+S EL + ++ + L +AE + ++ + +I
Sbjct: 744 EERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 193 AAERRQAKLEKEEAE--------RYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEH 244
A+ + K+E + E QS L +++Q + ++ +++ +++K+E
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863
Query: 245 VNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKEN 304
+++ LS K ++ + ++ +K++ L + +++ ++++ + + +K Q + K +
Sbjct: 864 LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923
Query: 305 TSHHLK----KLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILH 360
+K +L++ ++ + ++Q + + L+ ++ A + +++++ E
Sbjct: 924 LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDL 983
Query: 361 KKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGN 420
K++ E +L ++++ ++V+ + ++L L+ E K + + + GEV+ +
Sbjct: 984 LKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE---IPLSETERGEVEED 1040
Query: 421 LKQIKEQIEDH-KKRIEKLEEYTKTCMD-----------CLKEK-----------KQQEE 457
K+ KE E + +++E Y K + L+EK KQ +
Sbjct: 1041 -KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQ 1099
Query: 458 TLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVL----------EHL 507
TL D+ + +E +E +I+ +L + D +G E + EH
Sbjct: 1100 TLQDKTNQIDLLQAEISENQAIIQ-KLITSNTDASDGDSVALVKETVVISPPCTGSSEHW 1158
Query: 508 KRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEP 567
K + + L + KK Q A+T + I E+ ++ ++ K++
Sbjct: 1159 KPELEEKILA-LEKEKEQLQKKLQEALTS--RKAILKKAQEKERHLREELKQQKDDYNRL 1215
Query: 568 ETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARH 627
+ + + I ++LR+L+ V + I + P + GL E + +A
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQ--IQVRESIDGKLPSTDQQESCSSTPGLE-EPLFKATE 1272
Query: 628 IALSGPERQKTVALDGTLFLK-SGVISGGSSDLKYKARCWD-EKELKNLRDRRSQKIQEL 685
+ P + + D + + + GG+S + KA+ + E E L + S EL
Sbjct: 1273 QHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSEL 1332
Query: 686 KGLMKTLRKETDLKQIQTLI--QGTQTR-LKYSQNELEMIKKKHLVAFYQEQSQLQSELL 742
+K ++ Q+Q I QG + LK +E E+ H + Q+ Q ++
Sbjct: 1333 T------KKSEEVFQLQEQINKQGLEIESLKTVSHEAEV----HAESLQQKLESSQLQIA 1382
Query: 743 NIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQE 802
+E ++E Q ++ E Q+ I K E+D+ + + E E K Q E
Sbjct: 1383 GLEH--------LRELQPKLDELQKLISKKEEDVSYLSGQ------LSEKEAALTKIQTE 1428
Query: 803 IDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQT 862
I +E E L+ QLE +++ ++ +++ E+I +A++ +
Sbjct: 1429 I----IEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRK 1484
Query: 863 VNE-LMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQ 921
+ L+++++ LK+ + Q + T IE K V+ +V KE ++ L
Sbjct: 1485 LQAALISRKEALKENKSLQEELSLARGT-IERLTKSLADVESQVSAQNKEKDTVLGRLAL 1543
Query: 922 KRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSS 981
+ E+ L+ + +E LS S + + G + + +I + + + +
Sbjct: 1544 LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE 1603
Query: 982 LKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAF 1041
+E K LQ + EI LLQ S E++ A +E ++ + + +
Sbjct: 1604 WQEKHKELQKEYEI------LLQ---SYENV-SNEAERIQHVVEAVRQEKQELYGKLRST 1653
Query: 1042 EASRKEARLCRQEFEQ 1057
EA++KE QE EQ
Sbjct: 1654 EANKKETEKQLQEAEQ 1669
Score = 70.5 bits (171), Expect = 1e-11
Identities = 190/1032 (18%), Positives = 411/1032 (39%), Gaps = 174/1032 (16%)
Query: 159 STSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKE---EAERYQSLLEE 215
S + ++ + + K++LQ +E + K+K+ ERR + E++ E + Q L+
Sbjct: 2089 SEAARVLADNLKLKKELQSNKESVKSQM-KQKDEDLERRLEQAEEKHLKEKKNMQEKLDA 2147
Query: 216 LKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTR 275
L+ K+ H E+ I + L ++++ +E+L + A K L
Sbjct: 2148 LRREKV--------HLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 276 QLQQTEKELKSVETLLN---QKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDD 332
+ E K E + Q + + I+ KE+ LK D +Q S ++
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLK----------DQLRQMSIHMEE 2249
Query: 333 IKALETELADLDAAWRS---FEKQIEEEILHKKRDIELEA-SQLDRYKELKEQVRKKVAT 388
+K + L W S E Q+++++ + E SQL+ + L + ++A
Sbjct: 2250 LKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAK 2309
Query: 389 MTQQLEKLQWEQKTD-EERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLE-------E 440
+ +L+ L+ +Q TD L K + G ++G ++Q + I++ K E+LE E
Sbjct: 2310 LESELKSLK-DQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE 2368
Query: 441 YTKTCMDCLKEKKQQ--------EETLVDEIEKTKSRMSEFNEELN--LIRSELQNAGID 490
T + + K+Q+ EE + I + + + + +EL L + E +N ++
Sbjct: 2369 LTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLE 2428
Query: 491 THEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASE 550
K K +++E LK + +++ Q A F + ++++ +
Sbjct: 2429 EENKKAVDKTNQLMETLKTIKKENI--------------QQKAQLDSFVKSMSSLQNDRD 2474
Query: 551 KVAKDCIRFLKEERAEPETFLALDYL--DIKPINERLRE-LKGCKMVIDVIKTQFPQLK- 606
++ D + + E L D L + N +L+E ++G + +D + ++ +L
Sbjct: 2475 RIVGD---YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDA 2531
Query: 607 KVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGT---LFLKSGVISGGSSDLKYKA 663
++IQ+ V T+++++ L + Q+ L+ L K + DL+
Sbjct: 2532 ELIQYREDLNQVI-TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSF 2590
Query: 664 RCWDE------KELKNLRDRRSQKIQELKGLMK--TLR--------KETDLKQIQTLIQG 707
E KE+++L+ SQ +++ L + TL KE ++ ++ L
Sbjct: 2591 NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS 2650
Query: 708 TQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQE 767
+Q R+ + EL ++K+ + + +L+ EL ++ ++ + + R+ E
Sbjct: 2651 SQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELAR 2710
Query: 768 KIDKVEDDIFQHFCEEIGV--------------ENIREFENKHV---KRQQEIDQKRLEF 810
+ ++E + E G+ +N R+ N+ + KR+ + K L
Sbjct: 2711 DLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQ 2770
Query: 811 EKQKTRLNVQL---------------EYSRSHLKK---------------------KLNK 834
K++ LN + E S SHL+K N+
Sbjct: 2771 LKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
Query: 835 INTLKETIQKGSEDIDHL-------KKAEENCLQTV---NELMAKQQQLKDIRVTQNSSA 884
+ + + + + DHL +K+EE ++ + A+ Q LK + +
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR 2890
Query: 885 EKVQTQIEEERKKFLAVDREVGKLQKEVVSIQT--------SLEQKRLEKHNLLLDCKVQ 936
+++ +++ ++++L +++E+ +L +Q + Q+ L + NL
Sbjct: 2891 DRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQ---H 2947
Query: 937 DIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIE 996
++ + + S +I E M Q + I +K++ S L+ ++ L+S
Sbjct: 2948 ELHQLRMEKSSWEIHERRM-----KEQYLMAISDKDQ----QLSHLQNLIRELRSSSSQT 2998
Query: 997 AHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFE 1056
L++ Q+ AS E + NL + + +R + +S + F
Sbjct: 2999 QPLKVQYQRQASPETSASPDGSQNL--VYETELLRTQLNDSLKEIHQKELRIQQLNSNFS 3056
Query: 1057 QVKKRRYDLFTQ 1068
Q+ + + L Q
Sbjct: 3057 QLLEEKNTLSIQ 3068
Score = 66.6 bits (161), Expect = 1e-10
Identities = 184/976 (18%), Positives = 391/976 (40%), Gaps = 124/976 (12%)
Query: 187 NKKKNIAAERRQAKLEKEEAERYQSLL----------EELKMNKIQLQLFQLYHNEKKI- 235
NK+ + A E Q LE +++++ L EE+ K+QLQ + + ++
Sbjct: 534 NKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL 593
Query: 236 -----------HLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEK-- 282
+ K++ D + + E+ + A +KE Q + +E+
Sbjct: 594 DQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEIS 653
Query: 283 ------ELKSVETLLNQKRPQYIKAKENTSH-HLKKLDVAKKSIKDSEKQCSKQED---- 331
ELKS + Q + + A + H +L+ K I + E K ++
Sbjct: 654 LNDAGVELKSTK----QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEK 709
Query: 332 DIKALETELADLDAAWRSFEKQIEEE-----ILHKKRDIEL-EASQLDRYKELKEQVRKK 385
++ E+++L+ F+K + L ++RD L + +L EL+ QV++
Sbjct: 710 NLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQL 769
Query: 386 VATMTQ--QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIK-----EQIEDHKKRIEKL 438
+ + + +L +E +T + L E+ ++ K +K +++D + + +
Sbjct: 770 EMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ 829
Query: 439 EEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQ- 497
++ L+ K+ + + + S++ E ++ L+ E+ E KR
Sbjct: 830 STLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDV 889
Query: 498 QKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCI 557
+ + +E + + F + +K+ L V + ++ +E+ K+ +
Sbjct: 890 ETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQV 949
Query: 558 RFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNG- 616
EE E + L +Y ++ P + +E + D++K + Q K+ +Q N
Sbjct: 950 ----EEDNEVSSGLKQNYDEMSPAGQISKE--ELQHEFDLLKKENEQRKRKLQAALINRK 1003
Query: 617 -LVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEK--ELK- 672
L+ +A E +K + L T + G + + +Y +C K E++
Sbjct: 1004 ELLQRVSRLEEELANLKDESKKEIPLSET---ERGEVEEDKENKEYSEKCVTSKCQEIEI 1060
Query: 673 NLRDRRSQKIQELKGLMKTLRKETDLK-QIQTLIQGTQTRLKYSQNELEMIKKKHLVAFY 731
L+ S+K EL+ + K L ++ + Q Q L++ L+ N++++
Sbjct: 1061 YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDL---------- 1110
Query: 732 QEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIRE 791
LQ+E+ E+Q I+ K D + D E + +
Sbjct: 1111 -----LQAEIS--ENQAIIQ-----------KLITSNTDASDGDSVALVKETVVISPPCT 1152
Query: 792 FENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYS----RSHLKKKLNKINTLKETIQKGSE 847
++H K E+++K L EK+K +L +L+ + ++ LKK K L+E +++ +
Sbjct: 1153 GSSEHWK--PELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD 1210
Query: 848 DIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGK 907
D + L++ + NE + Q + I+V ++ + T +E ++ + K
Sbjct: 1211 DYNRLQEQFDE-QSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFK 1269
Query: 908 LQKEVVSIQTSLEQKRL---EKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQA 964
E Q LE H+ + + L +I ++ E + +
Sbjct: 1270 -ATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSST 1328
Query: 965 TIDIYEK-EEAFEIDYSSLKE--DLKALQS-DQEIEAHLRLLLQQVASQEDIL-----LK 1015
T ++ +K EE F++ K+ ++++L++ E E H L Q++ S + + L+
Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR 1388
Query: 1016 TAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCR------QEFEQVKKRRYDLFTQC 1069
P L L+ L + +++ S + + S KEA L + ++ + +K L Q
Sbjct: 1389 ELQPKLDELQKLISKKEE-DVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQA 1447
Query: 1070 FEHVSISIDQIYKKLC 1085
EH I Q+ +LC
Sbjct: 1448 KEH-DERIKQLQVELC 1462
Score = 63.9 bits (154), Expect = 9e-10
Identities = 168/911 (18%), Positives = 371/911 (40%), Gaps = 98/911 (10%)
Query: 190 KNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDL 249
K+I ++ +K+EA + + + K+ K++L H + K+ LN +E +
Sbjct: 65 KDIIRQKDVQLQQKDEALQEERKAADNKIKKLKL------HAKAKLTSLNKYIEEMKAQG 118
Query: 250 SV-------KRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAK 302
E LS H+ + E + +LQ+ E+ + +++ L Q + +
Sbjct: 119 GTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE---QP 175
Query: 303 ENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELA------DLDAAWRSFEKQIEE 356
+S +++ + K+ +++ E+ S + + + E A + DA + + + E+
Sbjct: 176 AQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHED 235
Query: 357 EILH--KKRDIELEASQLDRYKELK-EQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRR 413
E+L + D+E E Q R + K E+ + + Q ++ LQ E L ++R
Sbjct: 236 ELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQE-------LTAAEQR 288
Query: 414 HGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEF 473
+ + L+Q++ + + +E E +K ++ ++ + + + +++ + E
Sbjct: 289 NQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
Query: 474 NEELNLIRSELQ---NAGIDTHEGKRQQKRAEVLEHLKRLYP-DSVFGRLFDL-CHPIHK 528
E+ ++EL+ +A H+ + ++K + +L K S L D +
Sbjct: 349 FEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQD 408
Query: 529 KYQLAVTKVFGRFITAIVVASEKVAKDCIRFL------KEERAEPETF--------LALD 574
K + AV + I + ++ +K+ +FL + E A +F A+
Sbjct: 409 KNEQAVQS--AQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVT 466
Query: 575 YLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPE 634
+I + +R+ EL+ K + + + +LK + + T+ EA++
Sbjct: 467 EENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQ----ITLLEAQNRTGEADR 522
Query: 635 RQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRK 694
+++ +S D+ KEL L + +E+ L L+
Sbjct: 523 EVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQG 582
Query: 695 ETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQ--CIMLS 752
K+ + + + Q E E I + F ++ Q + N ES +
Sbjct: 583 ----KRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKE 638
Query: 753 EGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEK 812
+ E Q R E+I + + ++ G +++ + Q E+++ + + +
Sbjct: 639 QASTEHQSRT---SEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILE 695
Query: 813 QKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQ 872
+ + E +L +K +I+ L + I++ KK +N L ++ Q
Sbjct: 696 LELNFHKAQEIYEKNLDEKAKEISNLNQLIEE-------FKKNADNNSSAFTALSEERDQ 748
Query: 873 LKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLD 932
L +V + S +++ Q+++ +R+ +L E + +L +++ H+L ++
Sbjct: 749 LLS-QVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQI--HSLSIE 804
Query: 933 CKVQDIEIILLSGSLDDI--IEVEMGTEAESTQATIDIYEKE--EAFE--IDYSSLKEDL 986
K +D++I +L LDD+ E T S Q+ + E E E E SS E+L
Sbjct: 805 AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEEL 864
Query: 987 KALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENL-KTVRDKFQESTD-AFEAS 1044
S +E+E + + +LL+ R +E L +T+ +K Q+ T+ +F +
Sbjct: 865 SQALSQKELE---------ITKMDQLLLE----KKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 1045 RKEARLCRQEF 1055
K +L ++F
Sbjct: 912 EKMVQLNEEKF 922
Score = 57.0 bits (136), Expect = 1e-07
Identities = 146/763 (19%), Positives = 308/763 (40%), Gaps = 116/763 (15%)
Query: 377 ELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKR-- 434
ELK+ +R+K + Q+ E LQ E+K + ++ K+ + L + + IE+ K +
Sbjct: 63 ELKDIIRQKDVQLQQKDEALQEERKAADNKI---KKLKLHAKAKLTSLNKYIEEMKAQGG 119
Query: 435 -IEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHE 493
+ E ++ + + +EE EIEK K ++ E E ++ ++++L A +
Sbjct: 120 TVLPTEPQSEEQLSKHDKSSTEEEM---EIEKIKHKLQEKEELISTLQAQLTQAQAEQPA 176
Query: 494 GKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKY--QLAVTKVFGRFITAIVVASEK 551
+ V+ + + L + Q V + RF T + + ++
Sbjct: 177 QSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDE 236
Query: 552 VAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQF 611
+ ++ + + E E L L K + E L G V+D+++ +
Sbjct: 237 L----LQLVTQADVETEMQQKLRVLQRK-LEEHEESLVGRAQVVDLLQQEL--------- 282
Query: 612 VCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKEL 671
T E R+ LS + Q+ A T L++ V + + +E
Sbjct: 283 ---------TAAEQRNQILS-QQLQQMEAEHNT--LRNTVET-------------EREES 317
Query: 672 KNLRDRRSQKIQELKGLMKTLRKETD--LKQIQTLIQG-TQTRLKYS----QNELEMIKK 724
K L ++ ++ E K L++E L+Q + Q + +YS +++ EM +K
Sbjct: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEK 377
Query: 725 -KHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEE 783
H+++ + +LQS ++ Q S+ ++++ + + + I ++ED + Q E
Sbjct: 378 TSHILSLQKTGQELQSACDALKDQ---NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKE- 433
Query: 784 IGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQ 843
I +F N+ +Q E + + E + + L+K++ ++ K +
Sbjct: 434 -----ISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALL 488
Query: 844 KGSEDIDHLKKAEENCLQTVNELMAKQQ-----------QLKDIRVTQNSSAEK-----V 887
S +++ LK E + L A+ + + DI ++SSAE+ +
Sbjct: 489 LSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL 548
Query: 888 QTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEK--HNLLLDCKVQDIEIILLSG 945
+ ++ K+ + E+ + Q+E+ ++ L+ KR E+ H +L +++ +E
Sbjct: 549 ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQME------ 602
Query: 946 SLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ 1005
+ I ++M E T + EE+ L A++ +Q H Q
Sbjct: 603 -GEGIAPIKMKVFLEDTGQDFPLMPNEES----------SLPAVEKEQASTEH------Q 645
Query: 1006 VASQEDILLKTAAPNLRAL-----ENLKTVRDKFQESTDAFEASRK---EARLCRQEFEQ 1057
+ E+I L A L++ ++L V D Q D E + E L + ++
Sbjct: 646 SRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQE 705
Query: 1058 VKKRRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLSPENPE 1100
+ ++ D + +++ I++ K N+SA LS E +
Sbjct: 706 IYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQ 748
Score = 53.5 bits (127), Expect = 1e-06
Identities = 166/876 (18%), Positives = 348/876 (39%), Gaps = 141/876 (16%)
Query: 120 ELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAE 179
EL+ +K QN + Q E +V+ + Q +++ + I ++ + LQ+ E
Sbjct: 390 ELQSACDALKDQNSKLLQDKNEQ-AVQSAQTIQQLEDQLQQKSKEISQFLNRL-PLQQHE 447
Query: 180 EDAQFNF----NKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKI 235
+Q +F N+ E A L+K E ++ L ++ I+L+ +L +K+
Sbjct: 448 TASQTSFPDVYNEGTQAVTEENIASLQKRVVE-LENEKGALLLSSIELE--ELKAENEKL 504
Query: 236 HLLNTKLEHVNR--------------DLSVKRESLSHH------ENIVKARKKEHGMLTR 275
T LE NR D++ KR S + EN + KE +L
Sbjct: 505 SSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLL 564
Query: 276 QLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLD-------VAKKSIKDSEKQ--- 325
++++ ++E+ ++ L KR + + +K+++ K ++D+ +
Sbjct: 565 EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPL 624
Query: 326 CSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKK 385
+E + A+E E A + + + EEI +EL++++ D K L V
Sbjct: 625 MPNEESSLPAVEKEQASTE-----HQSRTSEEISLNDAGVELKSTKQDGDKSLSA-VPDI 678
Query: 386 VATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTC 445
+LE+L+ + E L F K + + NL + ++I + + IE+ ++
Sbjct: 679 GQCHQDELERLK--SQILELELNFHKAQE-IYEKNLDEKAKEISNLNQLIEEFKKNADNN 735
Query: 446 MDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLE 505
++ + L+ ++ K S ++E +R++++ ++ E +RQ++ L+
Sbjct: 736 SSAFTALSEERDQLLSQV-KELSMVTE-------LRAQVKQLEMNLAEAERQRR----LD 783
Query: 506 HLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERA 565
+ + D++ K + + + + SE+ IR L+ +
Sbjct: 784 YESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ--STLIRSLQSQLQ 841
Query: 566 EPETFLALDYLDIKPINERLRELKGC--KMVIDVIKTQFPQLKKVIQFVCGNGLVCETME 623
E+ + ++ I+ ++ EL + +++ K L+K + E +
Sbjct: 842 NKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
Query: 624 EARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQ 683
+ I+ S E K V L+ F I L +R + K+ ++++
Sbjct: 902 QVTEISFSMTE--KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKK---------EQVE 950
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLN 743
E + L++ D + Q + Q+E +++KK++ Q + +LQ+ L+N
Sbjct: 951 EDNEVSSGLKQNYD-----EMSPAGQISKEELQHEFDLLKKEN----EQRKRKLQAALIN 1001
Query: 744 IESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEI 803
KE +R+ +E++ ++D E+K E
Sbjct: 1002 R-----------KELLQRVSRLEEELANLKD------------------ESKKEIPLSET 1032
Query: 804 DQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINT-LKETIQKGSEDIDHLKKAEENCLQT 862
++ +E +K+ EYS + K +I LK+TI + ++ H++K E L
Sbjct: 1033 ERGEVEEDKENK------EYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAA 1086
Query: 863 VNELMAKQQQLKDIRVTQNSSAEKVQTQIEEER---KKFL-----AVDREVGKLQKEVVS 914
+ A +Q+ + + + +Q +I E + +K + A D + L KE V
Sbjct: 1087 EEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVV 1146
Query: 915 I-----------QTSLEQK--RLEKHNLLLDCKVQD 937
I + LE+K LEK L K+Q+
Sbjct: 1147 ISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQE 1182
Score = 51.6 bits (122), Expect = 5e-06
Identities = 168/897 (18%), Positives = 343/897 (38%), Gaps = 152/897 (16%)
Query: 62 QELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSRSV---YI 118
+EL H + + ++ +E + A + + E + +NL+S+ +
Sbjct: 2367 RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
Query: 119 AELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEIST----SGELIGEYEE-KKR 173
E E + K + T++ ++++ + F + +S+ ++G+Y++ ++R
Sbjct: 2427 LEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEER 2486
Query: 174 KLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNE- 232
L E Q + AAE + K EE +S +++L +L + + E
Sbjct: 2487 HLSIILEKDQLI----QEAAAENNKLK---EEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
Query: 233 ----------KKIHLLNTKLEHVNRDLSVK----RESLSHHENIVKARKKEHGMLTRQLQ 278
++ LL +L+ N++L K E L E + ++ L + Q
Sbjct: 2540 LNQVITIKDSQQKQLLEVQLQQ-NKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQ 2598
Query: 279 QTEKELKSVETLLNQKRPQY---------------IKAKENTSHHLKKL-DVAKKSIKDS 322
KE++S++ ++Q Q +K KE H L L ++K I +
Sbjct: 2599 DLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAEL 2658
Query: 323 E-------KQCSKQEDDIK-ALETELADL--DAA-WRSFEKQIEEEILHKKRD-IELEAS 370
E K+ +K+ +I+ L+ EL L DA R+ + EE + RD +E+E
Sbjct: 2659 EEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQK 2718
Query: 371 QLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIED 430
L KE K + ++ + + + LQ + E L KR++ L Q+KEQ
Sbjct: 2719 LLMVTKENK-GLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLL 2777
Query: 431 HKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNA--- 487
+++R L E T M+ EE + +EK ++ +E+L + S+L+++
Sbjct: 2778 NRERDALLSE-TAFSMN------STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
Query: 488 --GIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAI 545
Q +R + L++ + S G+ P + + ++
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEK-FRKSEEGKQRSAAQPSTSPAE----------VQSL 2879
Query: 546 VVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQL 605
A + D R LKE + + +L IN+ + EL K + ++
Sbjct: 2880 KKAMSSLQNDRDRLLKELKNLQQQYL--------QINQEITELHPLKAQLQ----EYQDK 2927
Query: 606 KKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARC 665
K Q + EE R LS + +
Sbjct: 2928 TKAFQIM---------QEELRQENLSWQHELHQLRM------------------------ 2954
Query: 666 WDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKK 725
EK + +RR ++ + LM K+ L +Q LI+ L+ S ++ + +K +
Sbjct: 2955 --EKSSWEIHERRMKE----QYLMAISDKDQQLSHLQNLIR----ELRSSSSQTQPLKVQ 3004
Query: 726 HLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIG 785
+ E S N+ + +L + + + I + + +I ++ + F EE
Sbjct: 3005 YQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSN-FSQLLEEKN 3063
Query: 786 VENIREFENKHVKRQQE-----------IDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNK 834
+I+ + R+ + + +K+++ E Q LN+ + K +++
Sbjct: 3064 TLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQ-ELQAGPLNIDVAPGAPQEKNGVHR 3122
Query: 835 INTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQI 891
+ E +++ + ++ N Q VNEL ++ +D RV ++ + QI
Sbjct: 3123 -KSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQI 3178
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 105 bits (261), Expect = 3e-22
Identities = 177/878 (20%), Positives = 373/878 (42%), Gaps = 128/878 (14%)
Query: 140 VESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQA 199
+E + K + + F E+I+ +L + E K +L K EE+ Q + + A++ A
Sbjct: 1053 LEKLKRKLEGDASDFHEQIA---DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 200 KLEKEEAERYQSLLEE------LKMNKIQLQLFQLYHNEKKIHLLNTKLEHV------NR 247
+ E E + S L+E NK + Q L +++ L T+LE +
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQ 1166
Query: 248 DLSVKRES------------LSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKR 295
+L KRE HE V+ +++H +L + ++ K + L++ +
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Query: 296 PQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKAL----ETELADLDAAWRSFE 351
K + + L+ L AK+ ++ +K+ Q ++++ E A+L+ +
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 352 KQIEE----------EILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQK 401
++E + + +D+ +SQL +EL ++ ++ ++ +L +L+ E+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 402 TDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKR-------IEKLEEYTKTC---MDCLKE 451
+ +++L E ++ ++ + Q+ D KK+ +E LEE K ++ L +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 452 KKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQN-AGIDTHEGKRQQKRAEVLEHLKRL 510
+ +++ D++EKTK+R+ +EL+ + +L N + ++ K+Q+K ++L K +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1463
Query: 511 ---YPD--------------SVFGRLFDLCHPIHKKYQLAVT-KVFGRFITAIVVASEKV 552
Y D L + K +L T K+ + +V + + V
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 553 AKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDV----IKTQFP----- 603
K+ K +RA ET + ++ + + L+ + K+ ++V +K QF
Sbjct: 1524 GKNVHELEKSKRA-LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 604 ----------QLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTL----FLKS 649
QL++ + + E +E + AL+ ++K L+G L
Sbjct: 1583 RDEQNEEKRRQLQRQL-----HEYETELEDERKQRALAAAAKKK---LEGDLKDLELQAD 1634
Query: 650 GVISGGSSDL----KYKARCWD-EKELKNLRDRRSQKIQELKGLMKTLRK-ETDLKQIQT 703
I G + K +A+ D ++EL++ R R + K K + E DL Q+Q
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 704 LIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIK 763
+ + K + E E + ++ L + ++ LQ E +E++ L E ++E Q ++
Sbjct: 1695 DLAAAERARKQADLEKEELAEE-LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1753
Query: 764 EFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFE--------KQKT 815
+++ K + E+ E +N+ ++Q E K L + K K
Sbjct: 1754 AMSDRVRKATQQA-EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Query: 816 RLNV-QLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLK 874
+ + LE + L++++ + K+ K + D KK +E LQ +E +Q K
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD--KKLKEILLQVEDE-RKMAEQYK 1869
Query: 875 DIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV 912
+ N+ ++++ Q+EE ++ ++ KLQ+E+
Sbjct: 1870 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 90.5 bits (223), Expect = 9e-18
Identities = 202/1021 (19%), Positives = 406/1021 (39%), Gaps = 136/1021 (13%)
Query: 149 KERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAE---RRQAKLEKEE 205
KE Q +++ L+ E + + +L E+ + KK E +A+LE+EE
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 206 AERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKA 265
Q E KM + L L + E+ +LE V + +K+ E+ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ-KLQLEKVTAEAKIKKL-----EDEILV 989
Query: 266 RKKEHGMLTRQLQQTEKELKSVETLL---NQKRPQYIKAKENTSHHLKKLDVA----KKS 318
++ L+++ + E+ + + T L +K K K + +L+V +KS
Sbjct: 990 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 319 IKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKEL 378
++ EK K E D ++ADL A + Q+ + K+ +++ ++LD
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK----KEEELQAALARLDDEIAQ 1105
Query: 379 KEQVRKKVATMTQQLEKLQWEQKTDEERLAFEK--RRHGEVQGNLKQIKEQIED------ 430
K KK+ + + LQ + D ER A K ++ ++ L+ +K ++ED
Sbjct: 1106 KNNALKKIRELEGHISDLQ--EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 431 --------------------------HKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE 464
H+ +++++ + ++ L E+ +Q + ++
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 465 KTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEV-LEHLKRLYPDSVFGRLFDLC 523
K K + + N +L EL+ G E + ++K+ E ++ L+ D R +L
Sbjct: 1224 KNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA-ELN 1279
Query: 524 HPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINE 583
+H K Q V V G A A K+AKD + L + + + L + ++
Sbjct: 1280 DKVH-KLQNEVESVTGMLNEAEGKAI-KLAKD-VASLSSQLQDTQELLQEETRQKLNVST 1336
Query: 584 RLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDG 643
+LR+L+ + + ++ Q + + Q + E +I LS +++
Sbjct: 1337 KLRQLEEER---NSLQDQLDEEMEAKQNL-------ERHISTLNIQLSDSKKKLQDFAST 1386
Query: 644 TLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT---LRKETD--- 697
L+ G K R +KE++NL + +K L KT L++E D
Sbjct: 1387 VEALEEG-----------KKRF--QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 698 -----LKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLS 752
+Q+ + ++ Q + E + I K + E+ + ++E E++ + L+
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK----YADERDRAEAEAREKETKALSLA 1489
Query: 753 EGIKERQRRIKEFQ--EKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEF 810
++E +E + K+ K E + +++G +N+ E E + ++++ + +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG-KNVHELEKSKRALETQMEEMKTQL 1548
Query: 811 EKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQ 870
E+ + L + + L+ ++N + LK ++ + D ++ EE Q +L +
Sbjct: 1549 EELEDELQATED---AKLRLEVN-MQALKGQFERDLQARD--EQNEEKRRQLQRQLHEYE 1602
Query: 871 QQLKDIRVTQNSSAEKVQTQIEEERKKF-LAVD----------REVGKLQKEVVSIQTSL 919
+L+D R Q + A + ++E + K L D +++ KLQ ++ Q L
Sbjct: 1603 TELEDER-KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 920 EQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDY 979
E R + + K + + L L + E E QA + EKEE E
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL---EKEELAEELA 1718
Query: 980 SSLKEDLKALQSDQEIEAHLRLLLQQVASQEDIL------LKTAAPNLRALEN-LKTVRD 1032
SSL + +EA + L +++ ++ + ++ A L N L T R
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 1033 KFQESTDA---FEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNS 1089
Q++ A E KE R E E K ++ E +++ ++ R
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 1090 A 1090
A
Sbjct: 1839 A 1839
Score = 89.0 bits (219), Expect = 3e-17
Identities = 168/873 (19%), Positives = 373/873 (42%), Gaps = 109/873 (12%)
Query: 248 DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSH 307
+L +E EN +K +++H LT + +++L++ L Y +A+E
Sbjct: 860 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL-------YAEAEEMRVR 912
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIEL 367
K ++ + + E + ++ED + L+ E + E+Q+EEE +++ ++L
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK-LQL 971
Query: 368 EASQLD-RYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
E + + K+L+++ + M Q KL E+K EER++ ++ NL + +E
Sbjct: 972 EKVTAEAKIKKLEDE----ILVMDDQNNKLSKERKLLEERIS-------DLTTNLAEEEE 1020
Query: 427 QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRM----SEFNEELNLIRS 482
+ K + KL+ ++ + L+ + ++EE E+EK K ++ S+F+E++ +++
Sbjct: 1021 K----AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 483 ELQNAGIDTHEGKRQQKRAEVLEH-----------LKRLYPDSVFGRLFDLCHPIHKKYQ 531
++ A + K++++ L LK++ + G + DL + + +
Sbjct: 1077 QI--AELKMQLAKKEEELQAALARLDDEIAQKNNALKKI--RELEGHISDLQEDLDSE-R 1131
Query: 532 LAVTKV------FGRFITAIVVASEKVAKDCI--RFLKEERAEPETFL--ALDYLDIKPI 581
A K G + A+ E + L+ +R + T L ALD + +
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSH 1190
Query: 582 NERLRELK-GCKMVIDVIKTQFPQLKKVIQFVCGN--GLVCETMEEARHIALSGPERQKT 638
+++E++ ++ + Q Q K+ + N L E + A + + G +Q+
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 639 VALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLM-----KTLR 693
L + + SD + +AR EL + + +++ + G++ K ++
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGE-RARA----ELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 694 KETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSEL-------LNIES 746
D+ + + +Q TQ L+ + + K L +E++ LQ +L N+E
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 747 QCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQK 806
L+ + + ++++++F ++ +E+ + F +EI EN+ + + ++++
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEG-KKRFQKEI--ENLTQQYEEKAAAYDKLEKT 1421
Query: 807 RLEFEKQKTRLNVQLEYSR---SHLKKKLNKIN-TLKETIQKGSEDIDHLKKAEENCLQT 862
+ +++ L V L+ R S+L+KK K + L E S+ D +AE +
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 863 VNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGK----LQKEVVSIQTS 918
+ ++ + L++ + E+ ++ E + ++ +VGK L+K +++T
Sbjct: 1482 ETKALSLARALEE-ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 919 LEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEID 978
+E+ + + L + L + D + +E+ +A Q D+ ++E E
Sbjct: 1541 MEEMKTQLEELEDE----------LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 979 YSSLKEDLKALQSDQEIEAHLRLL-----------LQQVASQEDILLKTAAPNLRALENL 1027
L+ L +++ E E R L L+ + Q D +K ++ L L
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 1028 KTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
+ FQ + ASR E +E E+ K
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Score = 70.1 bits (170), Expect = 1e-11
Identities = 152/785 (19%), Positives = 317/785 (40%), Gaps = 132/785 (16%)
Query: 392 QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE---QIEDHKKRI-EKLEEYTKTCMD 447
Q+ + + E + E+ L K R + + LK++++ Q+ + K + E+L+ T+ +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 448 C------LKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRA 501
L KKQ+ E ++ E+E + ++L R ++ +D E +++ A
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 502 EVLEHLKRLYPDSVFGRLFDLC-------HPIHKKYQLAVTKVFGRFITAIVVASEKVAK 554
L+++ ++ +L D + + K+ +L ++ +T + E+ AK
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD--LTTNLAEEEEKAK 1023
Query: 555 DCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQF-PQLKKVIQFVC 613
+ L + + + E+ ++ + +K + +EL+ K ++ + F Q+ + +
Sbjct: 1024 N----LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 614 GNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDL------KYKARCWD 667
+ EE AL+ + + +A K + G SDL + AR
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDE--IAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 668 EKELKNL---------------------RDRRSQKIQELKGLMKTLRKET--DLKQIQTL 704
EK+ ++L ++ R+++ QE+ L K L +ET Q+Q +
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 705 IQGTQTRLKYSQNELEMIKK------KHLVAFYQEQSQLQSEL--------------LNI 744
Q ++ +LE K+ K+ +E + L EL +
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 745 ESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEI- 803
E+Q L + +R E +K+ K+++++ E + E E K +K +++
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEV------ESVTGMLNEAEGKAIKLAKDVA 1311
Query: 804 -------DQKRLEFEKQKTRLNV-----QLEYSRSHLKKKLNKINTLKETIQKGSEDIDH 851
D + L E+ + +LNV QLE R+ L+ +L++ K+ +++ I
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER---HIST 1368
Query: 852 LKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKE 911
L + + + + + + L++ + E + Q EE+ + +++ +LQ+E
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 912 VVSIQTSLEQKR-----LEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATI 966
+ + L+ +R LEK D + + E + S D+ E + T+A
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALS 1487
Query: 967 DIYEKEEAFEI----------------DYSSLKEDL-----KALQSDQEIEAHLRLLLQQ 1005
EEA E D S K+D+ + +S + +E + + Q
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 1006 VASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEAR--LCRQ------EFEQ 1057
+ ED L T LR N++ ++ +F+ A + +E R L RQ E E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 1058 VKKRR 1062
+K+R
Sbjct: 1608 ERKQR 1612
Score = 68.2 bits (165), Expect = 5e-11
Identities = 86/401 (21%), Positives = 185/401 (46%), Gaps = 62/401 (15%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVA-----FYQEQSQLQ 738
++K L++ R+E +++ + +Q T+ R + ++NEL+ +++KH QEQ Q +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 739 SEL-LNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHV 797
+EL E + L+ +E + + E + ++++ ED
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED----------------------- 936
Query: 798 KRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKK-KLNKINTLKETIQKGSEDIDHLKKAE 856
R Q++ +R + +Q L QLE + +K +L K+ T + I+K ++I
Sbjct: 937 -RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV-TAEAKIKKLEDEI------- 987
Query: 857 ENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQ 916
+ N ++K+++L + R++ + T + EE +K + + KL+ + S+
Sbjct: 988 -LVMDDQNNKLSKERKLLEERISD------LTTNLAEEEEK----AKNLTKLKNKHESMI 1036
Query: 917 TSLEQKRLEKHNLLLDCKVQDIEII--LLSGSLDDIIEVEMGTEAESTQATIDIYEKEEA 974
+ LE RL+K + Q++E + L G D E +A+ + + + +KEE
Sbjct: 1037 SELE-VRLKKE----EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 975 FEIDYSSLKEDL----KALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTV 1030
+ + L +++ AL+ +E+E H+ L + + S+ K E L+ +
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 1031 RDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
+ + +++ D+ A+++E R R++ V K+ D T+ E
Sbjct: 1152 KTELEDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHE 1191
Score = 64.3 bits (155), Expect = 7e-10
Identities = 82/431 (19%), Positives = 189/431 (43%), Gaps = 66/431 (15%)
Query: 668 EKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHL 727
E ELK L + SQ +E L + L+ ET+L + + RL + ELE I +
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETEL---YAEAEEMRVRLAAKKQELEEILHEME 928
Query: 728 VAFYQEQ---SQLQSELLNIESQCIMLSEGIKERQRRIKEFQ-------EKIDKVEDDIF 777
+E+ QLQ+E + Q + L E ++E + ++ Q KI K+ED+I
Sbjct: 929 ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEIL 988
Query: 778 QHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINT 837
+ + +N + +++++ ++R+ L + + ++K +
Sbjct: 989 -----------VMDDQNNKLSKERKLLEERIS----------DLTTNLAEEEEKAKNLTK 1027
Query: 838 LKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKK 897
LK + +++ K EE +Q+L+ ++ A QI + + +
Sbjct: 1028 LKNKHESMISELEVRLKKEEK----------SRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 898 FLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGT 957
+ ++ K ++E+ + L+ + +K+N L K++++E + L + ++ E
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALK--KIRELEGHI--SDLQEDLDSERAA 1133
Query: 958 EAESTQATIDIYEKEEAFE------IDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
++ + D+ E+ EA + +D ++ +++L+A + +QE+ + L ++ S E
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA-KREQEVTVLKKALDEETRSHEA 1192
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRK-----------EARLCRQEFEQVKK 1060
+ + + +A+E L ++F+ + + +++ E R+ Q ++V+
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 1061 RRYDLFTQCFE 1071
++ L Q E
Sbjct: 1253 KKKKLEAQVQE 1263
Score = 61.6 bits (148), Expect = 4e-09
Identities = 126/713 (17%), Positives = 298/713 (41%), Gaps = 92/713 (12%)
Query: 383 RKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYT 442
RK A QQL ++ Q+ A+ K R+ + ++K ++ + + EE
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCA---AYLKLRNWQWWRLFTKVKPLLQ-----VTRQEEEM 854
Query: 443 KTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAE 502
+ D L++ K++++ +E+++ + + S+ EE NL++ +LQ + AE
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ---------AETELYAE 905
Query: 503 VLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKE 562
E RL L ++ H + + + + G+ + A +K+A+ + L+E
Sbjct: 906 AEEMRVRLAAKK--QELEEILHEMEARLEEEEDR--GQQLQA---ERKKMAQQMLD-LEE 957
Query: 563 ERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGN--GLVCE 620
+ E E L+ ++++L+ +V+D + + +K+++ + + E
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 621 TMEEARHIALSGPERQKTVALDGTLFLK-----------SGVISGGSSDLKYKARCWDEK 669
E+A+++ + + ++ K + G +SD ++ +
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQA 1076
Query: 670 ELKNLRDRRSQKIQELKGLMKTL-----RKETDLKQIQTL------IQGTQTRLKYSQNE 718
++ L+ + ++K +EL+ + L +K LK+I+ L +Q + ++N+
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 719 LEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQ 778
E K+ +E L++EL + E +R++ + ++ +D ++
Sbjct: 1137 AEKQKRD----LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD---EETRS 1189
Query: 779 HFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTL 838
H + ++E KH + +E+ ++ +F++ K L+ ++ L+K+ +
Sbjct: 1190 HEAQ------VQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKENADLAGE 1239
Query: 839 KETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIE------ 892
+ + ++++H KK E V EL +K + R N K+Q ++E
Sbjct: 1240 LRVLGQAKQEVEHKKKKLE---AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 893 -EERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951
E K + + ++V L ++ Q L+++ +K N+ + + E L LD+ +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 952 EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
E + E + I + + ++ + D++S E L+ + + + + L QQ +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALE--EGKKRFQKEIENLTQQYEEK-- 1411
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYD 1064
A + L+ +++ Q+ D R E+ K+R++D
Sbjct: 1412 ---------AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK-KQRKFD 1454
Score = 60.8 bits (146), Expect = 8e-09
Identities = 76/371 (20%), Positives = 152/371 (40%), Gaps = 60/371 (16%)
Query: 153 QFFEEISTSGELIGEYEEKKRKLQKA--EEDAQFNFNKKKNIAAERRQAKLEKE------ 204
QF ++ E + EEK+R+LQ+ E + + +K+ A + KLE +
Sbjct: 1575 QFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631
Query: 205 ----EAERYQSLLEELKMNKIQLQLFQ----------------LYHNEKKIHLLNTKLEH 244
+ + +++L+ + Q++ FQ NEKK L L
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1691
Query: 245 VNRDLSVKR--------------ESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETL 290
+ DL+ E L+ + A + E L ++ Q E+EL+ +
Sbjct: 1692 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
Query: 291 LNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSF 350
+ + KA + +L + + + +E + E K L ++L +++ A +S
Sbjct: 1752 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1811
Query: 351 EKQ----IEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEER 406
K +E +I + +E EA + + +Q KK+ + Q+E DE +
Sbjct: 1812 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE--------DERK 1863
Query: 407 LAFEKRRHGEVQGN--LKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE 464
+A + + E +GN +KQ+K Q+E+ ++ +++ + L E + E + E+
Sbjct: 1864 MAEQYKEQAE-KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Query: 465 KTKSRMSEFNE 475
KS++ NE
Sbjct: 1923 ALKSKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 105 bits (261), Expect = 3e-22
Identities = 177/878 (20%), Positives = 373/878 (42%), Gaps = 128/878 (14%)
Query: 140 VESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQA 199
+E + K + + F E+I+ +L + E K +L K EE+ Q + + A++ A
Sbjct: 1060 LEKLKRKLEGDASDFHEQIA---DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 200 KLEKEEAERYQSLLEE------LKMNKIQLQLFQLYHNEKKIHLLNTKLEHV------NR 247
+ E E + S L+E NK + Q L +++ L T+LE +
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQ 1173
Query: 248 DLSVKRES------------LSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKR 295
+L KRE HE V+ +++H +L + ++ K + L++ +
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Query: 296 PQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKAL----ETELADLDAAWRSFE 351
K + + L+ L AK+ ++ +K+ Q ++++ E A+L+ +
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 352 KQIEE----------EILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQK 401
++E + + +D+ +SQL +EL ++ ++ ++ +L +L+ E+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 402 TDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKR-------IEKLEEYTKTC---MDCLKE 451
+ +++L E ++ ++ + Q+ D KK+ +E LEE K ++ L +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 452 KKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQN-AGIDTHEGKRQQKRAEVLEHLKRL 510
+ +++ D++EKTK+R+ +EL+ + +L N + ++ K+Q+K ++L K +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 511 ---YPD--------------SVFGRLFDLCHPIHKKYQLAVT-KVFGRFITAIVVASEKV 552
Y D L + K +L T K+ + +V + + V
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 553 AKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDV----IKTQFP----- 603
K+ K +RA ET + ++ + + L+ + K+ ++V +K QF
Sbjct: 1531 GKNVHELEKSKRA-LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 604 ----------QLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTL----FLKS 649
QL++ + + E +E + AL+ ++K L+G L
Sbjct: 1590 RDEQNEEKRRQLQRQL-----HEYETELEDERKQRALAAAAKKK---LEGDLKDLELQAD 1641
Query: 650 GVISGGSSDL----KYKARCWD-EKELKNLRDRRSQKIQELKGLMKTLRK-ETDLKQIQT 703
I G + K +A+ D ++EL++ R R + K K + E DL Q+Q
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 704 LIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIK 763
+ + K + E E + ++ L + ++ LQ E +E++ L E ++E Q ++
Sbjct: 1702 DLAAAERARKQADLEKEELAEE-LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1760
Query: 764 EFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFE--------KQKT 815
+++ K + E+ E +N+ ++Q E K L + K K
Sbjct: 1761 AMSDRVRKATQQA-EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Query: 816 RLNV-QLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLK 874
+ + LE + L++++ + K+ K + D KK +E LQ +E +Q K
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD--KKLKEILLQVEDE-RKMAEQYK 1876
Query: 875 DIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV 912
+ N+ ++++ Q+EE ++ ++ KLQ+E+
Sbjct: 1877 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 90.5 bits (223), Expect = 9e-18
Identities = 202/1021 (19%), Positives = 406/1021 (39%), Gaps = 136/1021 (13%)
Query: 149 KERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAE---RRQAKLEKEE 205
KE Q +++ L+ E + + +L E+ + KK E +A+LE+EE
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 206 AERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKA 265
Q E KM + L L + E+ +LE V + +K+ E+ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ-KLQLEKVTAEAKIKKL-----EDEILV 996
Query: 266 RKKEHGMLTRQLQQTEKELKSVETLL---NQKRPQYIKAKENTSHHLKKLDVA----KKS 318
++ L+++ + E+ + + T L +K K K + +L+V +KS
Sbjct: 997 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 319 IKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKEL 378
++ EK K E D ++ADL A + Q+ + K+ +++ ++LD
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK----KEEELQAALARLDDEIAQ 1112
Query: 379 KEQVRKKVATMTQQLEKLQWEQKTDEERLAFEK--RRHGEVQGNLKQIKEQIED------ 430
K KK+ + + LQ + D ER A K ++ ++ L+ +K ++ED
Sbjct: 1113 KNNALKKIRELEGHISDLQ--EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 431 --------------------------HKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE 464
H+ +++++ + ++ L E+ +Q + ++
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 465 KTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEV-LEHLKRLYPDSVFGRLFDLC 523
K K + + N +L EL+ G E + ++K+ E ++ L+ D R +L
Sbjct: 1231 KNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA-ELN 1286
Query: 524 HPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINE 583
+H K Q V V G A A K+AKD + L + + + L + ++
Sbjct: 1287 DKVH-KLQNEVESVTGMLNEAEGKAI-KLAKD-VASLSSQLQDTQELLQEETRQKLNVST 1343
Query: 584 RLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDG 643
+LR+L+ + + ++ Q + + Q + E +I LS +++
Sbjct: 1344 KLRQLEEER---NSLQDQLDEEMEAKQNL-------ERHISTLNIQLSDSKKKLQDFAST 1393
Query: 644 TLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT---LRKETD--- 697
L+ G K R +KE++NL + +K L KT L++E D
Sbjct: 1394 VEALEEG-----------KKRF--QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 698 -----LKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLS 752
+Q+ + ++ Q + E + I K + E+ + ++E E++ + L+
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK----YADERDRAEAEAREKETKALSLA 1496
Query: 753 EGIKERQRRIKEFQ--EKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEF 810
++E +E + K+ K E + +++G +N+ E E + ++++ + +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG-KNVHELEKSKRALETQMEEMKTQL 1555
Query: 811 EKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQ 870
E+ + L + + L+ ++N + LK ++ + D ++ EE Q +L +
Sbjct: 1556 EELEDELQATED---AKLRLEVN-MQALKGQFERDLQARD--EQNEEKRRQLQRQLHEYE 1609
Query: 871 QQLKDIRVTQNSSAEKVQTQIEEERKKF-LAVD----------REVGKLQKEVVSIQTSL 919
+L+D R Q + A + ++E + K L D +++ KLQ ++ Q L
Sbjct: 1610 TELEDER-KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 920 EQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDY 979
E R + + K + + L L + E E QA + EKEE E
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL---EKEELAEELA 1725
Query: 980 SSLKEDLKALQSDQEIEAHLRLLLQQVASQEDIL------LKTAAPNLRALEN-LKTVRD 1032
SSL + +EA + L +++ ++ + ++ A L N L T R
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 1033 KFQESTDA---FEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNS 1089
Q++ A E KE R E E K ++ E +++ ++ R
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 1090 A 1090
A
Sbjct: 1846 A 1846
Score = 89.0 bits (219), Expect = 3e-17
Identities = 168/873 (19%), Positives = 373/873 (42%), Gaps = 109/873 (12%)
Query: 248 DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSH 307
+L +E EN +K +++H LT + +++L++ L Y +A+E
Sbjct: 867 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL-------YAEAEEMRVR 919
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIEL 367
K ++ + + E + ++ED + L+ E + E+Q+EEE +++ ++L
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK-LQL 978
Query: 368 EASQLD-RYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
E + + K+L+++ + M Q KL E+K EER++ ++ NL + +E
Sbjct: 979 EKVTAEAKIKKLEDE----ILVMDDQNNKLSKERKLLEERIS-------DLTTNLAEEEE 1027
Query: 427 QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRM----SEFNEELNLIRS 482
+ K + KL+ ++ + L+ + ++EE E+EK K ++ S+F+E++ +++
Sbjct: 1028 K----AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 483 ELQNAGIDTHEGKRQQKRAEVLEH-----------LKRLYPDSVFGRLFDLCHPIHKKYQ 531
++ A + K++++ L LK++ + G + DL + + +
Sbjct: 1084 QI--AELKMQLAKKEEELQAALARLDDEIAQKNNALKKI--RELEGHISDLQEDLDSE-R 1138
Query: 532 LAVTKV------FGRFITAIVVASEKVAKDCI--RFLKEERAEPETFL--ALDYLDIKPI 581
A K G + A+ E + L+ +R + T L ALD + +
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSH 1197
Query: 582 NERLRELK-GCKMVIDVIKTQFPQLKKVIQFVCGN--GLVCETMEEARHIALSGPERQKT 638
+++E++ ++ + Q Q K+ + N L E + A + + G +Q+
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 639 VALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLM-----KTLR 693
L + + SD + +AR EL + + +++ + G++ K ++
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGE-RARA----ELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 694 KETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSEL-------LNIES 746
D+ + + +Q TQ L+ + + K L +E++ LQ +L N+E
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 747 QCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQK 806
L+ + + ++++++F ++ +E+ + F +EI EN+ + + ++++
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEG-KKRFQKEI--ENLTQQYEEKAAAYDKLEKT 1428
Query: 807 RLEFEKQKTRLNVQLEYSR---SHLKKKLNKIN-TLKETIQKGSEDIDHLKKAEENCLQT 862
+ +++ L V L+ R S+L+KK K + L E S+ D +AE +
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 863 VNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGK----LQKEVVSIQTS 918
+ ++ + L++ + E+ ++ E + ++ +VGK L+K +++T
Sbjct: 1489 ETKALSLARALEE-ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 919 LEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEID 978
+E+ + + L + L + D + +E+ +A Q D+ ++E E
Sbjct: 1548 MEEMKTQLEELEDE----------LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 979 YSSLKEDLKALQSDQEIEAHLRLL-----------LQQVASQEDILLKTAAPNLRALENL 1027
L+ L +++ E E R L L+ + Q D +K ++ L L
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 1028 KTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
+ FQ + ASR E +E E+ K
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Score = 70.1 bits (170), Expect = 1e-11
Identities = 152/785 (19%), Positives = 317/785 (40%), Gaps = 132/785 (16%)
Query: 392 QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE---QIEDHKKRI-EKLEEYTKTCMD 447
Q+ + + E + E+ L K R + + LK++++ Q+ + K + E+L+ T+ +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 448 C------LKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRA 501
L KKQ+ E ++ E+E + ++L R ++ +D E +++ A
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 502 EVLEHLKRLYPDSVFGRLFDLC-------HPIHKKYQLAVTKVFGRFITAIVVASEKVAK 554
L+++ ++ +L D + + K+ +L ++ +T + E+ AK
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD--LTTNLAEEEEKAK 1030
Query: 555 DCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQF-PQLKKVIQFVC 613
+ L + + + E+ ++ + +K + +EL+ K ++ + F Q+ + +
Sbjct: 1031 N----LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 614 GNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDL------KYKARCWD 667
+ EE AL+ + + +A K + G SDL + AR
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDE--IAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 668 EKELKNL---------------------RDRRSQKIQELKGLMKTLRKET--DLKQIQTL 704
EK+ ++L ++ R+++ QE+ L K L +ET Q+Q +
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 705 IQGTQTRLKYSQNELEMIKK------KHLVAFYQEQSQLQSEL--------------LNI 744
Q ++ +LE K+ K+ +E + L EL +
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 745 ESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEI- 803
E+Q L + +R E +K+ K+++++ E + E E K +K +++
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEV------ESVTGMLNEAEGKAIKLAKDVA 1318
Query: 804 -------DQKRLEFEKQKTRLNV-----QLEYSRSHLKKKLNKINTLKETIQKGSEDIDH 851
D + L E+ + +LNV QLE R+ L+ +L++ K+ +++ I
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER---HIST 1375
Query: 852 LKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKE 911
L + + + + + + L++ + E + Q EE+ + +++ +LQ+E
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 912 VVSIQTSLEQKR-----LEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATI 966
+ + L+ +R LEK D + + E + S D+ E + T+A
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALS 1494
Query: 967 DIYEKEEAFEI----------------DYSSLKEDL-----KALQSDQEIEAHLRLLLQQ 1005
EEA E D S K+D+ + +S + +E + + Q
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 1006 VASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEAR--LCRQ------EFEQ 1057
+ ED L T LR N++ ++ +F+ A + +E R L RQ E E
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 1058 VKKRR 1062
+K+R
Sbjct: 1615 ERKQR 1619
Score = 68.2 bits (165), Expect = 5e-11
Identities = 86/401 (21%), Positives = 185/401 (46%), Gaps = 62/401 (15%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVA-----FYQEQSQLQ 738
++K L++ R+E +++ + +Q T+ R + ++NEL+ +++KH QEQ Q +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 739 SEL-LNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHV 797
+EL E + L+ +E + + E + ++++ ED
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED----------------------- 943
Query: 798 KRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKK-KLNKINTLKETIQKGSEDIDHLKKAE 856
R Q++ +R + +Q L QLE + +K +L K+ T + I+K ++I
Sbjct: 944 -RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV-TAEAKIKKLEDEI------- 994
Query: 857 ENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQ 916
+ N ++K+++L + R++ + T + EE +K + + KL+ + S+
Sbjct: 995 -LVMDDQNNKLSKERKLLEERISD------LTTNLAEEEEK----AKNLTKLKNKHESMI 1043
Query: 917 TSLEQKRLEKHNLLLDCKVQDIEII--LLSGSLDDIIEVEMGTEAESTQATIDIYEKEEA 974
+ LE RL+K + Q++E + L G D E +A+ + + + +KEE
Sbjct: 1044 SELE-VRLKKE----EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 975 FEIDYSSLKEDL----KALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTV 1030
+ + L +++ AL+ +E+E H+ L + + S+ K E L+ +
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 1031 RDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
+ + +++ D+ A+++E R R++ V K+ D T+ E
Sbjct: 1159 KTELEDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHE 1198
Score = 64.3 bits (155), Expect = 7e-10
Identities = 82/431 (19%), Positives = 189/431 (43%), Gaps = 66/431 (15%)
Query: 668 EKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHL 727
E ELK L + SQ +E L + L+ ET+L + + RL + ELE I +
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETEL---YAEAEEMRVRLAAKKQELEEILHEME 935
Query: 728 VAFYQEQ---SQLQSELLNIESQCIMLSEGIKERQRRIKEFQ-------EKIDKVEDDIF 777
+E+ QLQ+E + Q + L E ++E + ++ Q KI K+ED+I
Sbjct: 936 ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEIL 995
Query: 778 QHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINT 837
+ + +N + +++++ ++R+ L + + ++K +
Sbjct: 996 -----------VMDDQNNKLSKERKLLEERIS----------DLTTNLAEEEEKAKNLTK 1034
Query: 838 LKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKK 897
LK + +++ K EE +Q+L+ ++ A QI + + +
Sbjct: 1035 LKNKHESMISELEVRLKKEEK----------SRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 898 FLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGT 957
+ ++ K ++E+ + L+ + +K+N L K++++E + L + ++ E
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALK--KIRELEGHI--SDLQEDLDSERAA 1140
Query: 958 EAESTQATIDIYEKEEAFE------IDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
++ + D+ E+ EA + +D ++ +++L+A + +QE+ + L ++ S E
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA-KREQEVTVLKKALDEETRSHEA 1199
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRK-----------EARLCRQEFEQVKK 1060
+ + + +A+E L ++F+ + + +++ E R+ Q ++V+
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 1061 RRYDLFTQCFE 1071
++ L Q E
Sbjct: 1260 KKKKLEAQVQE 1270
Score = 61.6 bits (148), Expect = 4e-09
Identities = 126/713 (17%), Positives = 298/713 (41%), Gaps = 92/713 (12%)
Query: 383 RKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYT 442
RK A QQL ++ Q+ A+ K R+ + ++K ++ + + EE
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCA---AYLKLRNWQWWRLFTKVKPLLQ-----VTRQEEEM 861
Query: 443 KTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAE 502
+ D L++ K++++ +E+++ + + S+ EE NL++ +LQ + AE
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ---------AETELYAE 912
Query: 503 VLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKE 562
E RL L ++ H + + + + G+ + A +K+A+ + L+E
Sbjct: 913 AEEMRVRLAAKK--QELEEILHEMEARLEEEEDR--GQQLQA---ERKKMAQQMLD-LEE 964
Query: 563 ERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGN--GLVCE 620
+ E E L+ ++++L+ +V+D + + +K+++ + + E
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 621 TMEEARHIALSGPERQKTVALDGTLFLK-----------SGVISGGSSDLKYKARCWDEK 669
E+A+++ + + ++ K + G +SD ++ +
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQA 1083
Query: 670 ELKNLRDRRSQKIQELKGLMKTL-----RKETDLKQIQTL------IQGTQTRLKYSQNE 718
++ L+ + ++K +EL+ + L +K LK+I+ L +Q + ++N+
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 719 LEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQ 778
E K+ +E L++EL + E +R++ + ++ +D ++
Sbjct: 1144 AEKQKRD----LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD---EETRS 1196
Query: 779 HFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTL 838
H + ++E KH + +E+ ++ +F++ K L+ ++ L+K+ +
Sbjct: 1197 HEAQ------VQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKENADLAGE 1246
Query: 839 KETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIE------ 892
+ + ++++H KK E V EL +K + R N K+Q ++E
Sbjct: 1247 LRVLGQAKQEVEHKKKKLE---AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 893 -EERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951
E K + + ++V L ++ Q L+++ +K N+ + + E L LD+ +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 952 EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
E + E + I + + ++ + D++S E L+ + + + + L QQ +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALE--EGKKRFQKEIENLTQQYEEK-- 1418
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYD 1064
A + L+ +++ Q+ D R E+ K+R++D
Sbjct: 1419 ---------AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK-KQRKFD 1461
Score = 60.8 bits (146), Expect = 8e-09
Identities = 76/371 (20%), Positives = 152/371 (40%), Gaps = 60/371 (16%)
Query: 153 QFFEEISTSGELIGEYEEKKRKLQKA--EEDAQFNFNKKKNIAAERRQAKLEKE------ 204
QF ++ E + EEK+R+LQ+ E + + +K+ A + KLE +
Sbjct: 1582 QFERDLQARDE---QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638
Query: 205 ----EAERYQSLLEELKMNKIQLQLFQ----------------LYHNEKKIHLLNTKLEH 244
+ + +++L+ + Q++ FQ NEKK L L
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQ 1698
Query: 245 VNRDLSVKR--------------ESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETL 290
+ DL+ E L+ + A + E L ++ Q E+EL+ +
Sbjct: 1699 LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
Query: 291 LNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSF 350
+ + KA + +L + + + +E + E K L ++L +++ A +S
Sbjct: 1759 MEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK 1818
Query: 351 EKQ----IEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEER 406
K +E +I + +E EA + + +Q KK+ + Q+E DE +
Sbjct: 1819 FKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE--------DERK 1870
Query: 407 LAFEKRRHGEVQGN--LKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE 464
+A + + E +GN +KQ+K Q+E+ ++ +++ + L E + E + E+
Sbjct: 1871 MAEQYKEQAE-KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Query: 465 KTKSRMSEFNE 475
KS++ NE
Sbjct: 1930 ALKSKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 105 bits (261), Expect = 3e-22
Identities = 177/878 (20%), Positives = 373/878 (42%), Gaps = 128/878 (14%)
Query: 140 VESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQA 199
+E + K + + F E+I+ +L + E K +L K EE+ Q + + A++ A
Sbjct: 1060 LEKLKRKLEGDASDFHEQIA---DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116
Query: 200 KLEKEEAERYQSLLEE------LKMNKIQLQLFQLYHNEKKIHLLNTKLEHV------NR 247
+ E E + S L+E NK + Q L +++ L T+LE +
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQ 1173
Query: 248 DLSVKRES------------LSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKR 295
+L KRE HE V+ +++H +L + ++ K + L++ +
Sbjct: 1174 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1233
Query: 296 PQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKAL----ETELADLDAAWRSFE 351
K + + L+ L AK+ ++ +K+ Q ++++ E A+L+ +
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1293
Query: 352 KQIEE----------EILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQK 401
++E + + +D+ +SQL +EL ++ ++ ++ +L +L+ E+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 402 TDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKR-------IEKLEEYTKTC---MDCLKE 451
+ +++L E ++ ++ + Q+ D KK+ +E LEE K ++ L +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 452 KKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQN-AGIDTHEGKRQQKRAEVLEHLKRL 510
+ +++ D++EKTK+R+ +EL+ + +L N + ++ K+Q+K ++L K +
Sbjct: 1414 QYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 511 ---YPD--------------SVFGRLFDLCHPIHKKYQLAVT-KVFGRFITAIVVASEKV 552
Y D L + K +L T K+ + +V + + V
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 553 AKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDV----IKTQFP----- 603
K+ K +RA ET + ++ + + L+ + K+ ++V +K QF
Sbjct: 1531 GKNVHELEKSKRA-LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1589
Query: 604 ----------QLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTL----FLKS 649
QL++ + + E +E + AL+ ++K L+G L
Sbjct: 1590 RDEQNEEKRRQLQRQL-----HEYETELEDERKQRALAAAAKKK---LEGDLKDLELQAD 1641
Query: 650 GVISGGSSDL----KYKARCWD-EKELKNLRDRRSQKIQELKGLMKTLRK-ETDLKQIQT 703
I G + K +A+ D ++EL++ R R + K K + E DL Q+Q
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701
Query: 704 LIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIK 763
+ + K + E E + ++ L + ++ LQ E +E++ L E ++E Q ++
Sbjct: 1702 DLAAAERARKQADLEKEELAEE-LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1760
Query: 764 EFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFE--------KQKT 815
+++ K + E+ E +N+ ++Q E K L + K K
Sbjct: 1761 AMSDRVRKATQQA-EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Query: 816 RLNV-QLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLK 874
+ + LE + L++++ + K+ K + D KK +E LQ +E +Q K
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD--KKLKEILLQVEDE-RKMAEQYK 1876
Query: 875 DIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV 912
+ N+ ++++ Q+EE ++ ++ KLQ+E+
Sbjct: 1877 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Score = 90.5 bits (223), Expect = 9e-18
Identities = 202/1021 (19%), Positives = 406/1021 (39%), Gaps = 136/1021 (13%)
Query: 149 KERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAE---RRQAKLEKEE 205
KE Q +++ L+ E + + +L E+ + KK E +A+LE+EE
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 942
Query: 206 AERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKA 265
Q E KM + L L + E+ +LE V + +K+ E+ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ-KLQLEKVTAEAKIKKL-----EDEILV 996
Query: 266 RKKEHGMLTRQLQQTEKELKSVETLL---NQKRPQYIKAKENTSHHLKKLDVA----KKS 318
++ L+++ + E+ + + T L +K K K + +L+V +KS
Sbjct: 997 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056
Query: 319 IKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKEL 378
++ EK K E D ++ADL A + Q+ + K+ +++ ++LD
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK----KEEELQAALARLDDEIAQ 1112
Query: 379 KEQVRKKVATMTQQLEKLQWEQKTDEERLAFEK--RRHGEVQGNLKQIKEQIED------ 430
K KK+ + + LQ + D ER A K ++ ++ L+ +K ++ED
Sbjct: 1113 KNNALKKIRELEGHISDLQ--EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 431 --------------------------HKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE 464
H+ +++++ + ++ L E+ +Q + ++
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 465 KTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEV-LEHLKRLYPDSVFGRLFDLC 523
K K + + N +L EL+ G E + ++K+ E ++ L+ D R +L
Sbjct: 1231 KNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA-ELN 1286
Query: 524 HPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINE 583
+H K Q V V G A A K+AKD + L + + + L + ++
Sbjct: 1287 DKVH-KLQNEVESVTGMLNEAEGKAI-KLAKD-VASLSSQLQDTQELLQEETRQKLNVST 1343
Query: 584 RLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDG 643
+LR+L+ + + ++ Q + + Q + E +I LS +++
Sbjct: 1344 KLRQLEEER---NSLQDQLDEEMEAKQNL-------ERHISTLNIQLSDSKKKLQDFAST 1393
Query: 644 TLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT---LRKETD--- 697
L+ G K R +KE++NL + +K L KT L++E D
Sbjct: 1394 VEALEEG-----------KKRF--QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 698 -----LKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLS 752
+Q+ + ++ Q + E + I K + E+ + ++E E++ + L+
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK----YADERDRAEAEAREKETKALSLA 1496
Query: 753 EGIKERQRRIKEFQ--EKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEF 810
++E +E + K+ K E + +++G +N+ E E + ++++ + +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG-KNVHELEKSKRALETQMEEMKTQL 1555
Query: 811 EKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQ 870
E+ + L + + L+ ++N + LK ++ + D ++ EE Q +L +
Sbjct: 1556 EELEDELQATED---AKLRLEVN-MQALKGQFERDLQARD--EQNEEKRRQLQRQLHEYE 1609
Query: 871 QQLKDIRVTQNSSAEKVQTQIEEERKKF-LAVD----------REVGKLQKEVVSIQTSL 919
+L+D R Q + A + ++E + K L D +++ KLQ ++ Q L
Sbjct: 1610 TELEDER-KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 920 EQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDY 979
E R + + K + + L L + E E QA + EKEE E
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL---EKEELAEELA 1725
Query: 980 SSLKEDLKALQSDQEIEAHLRLLLQQVASQEDIL------LKTAAPNLRALEN-LKTVRD 1032
SSL + +EA + L +++ ++ + ++ A L N L T R
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 1033 KFQESTDA---FEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNS 1089
Q++ A E KE R E E K ++ E +++ ++ R
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1845
Query: 1090 A 1090
A
Sbjct: 1846 A 1846
Score = 89.0 bits (219), Expect = 3e-17
Identities = 168/873 (19%), Positives = 373/873 (42%), Gaps = 109/873 (12%)
Query: 248 DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSH 307
+L +E EN +K +++H LT + +++L++ L Y +A+E
Sbjct: 867 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL-------YAEAEEMRVR 919
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIEL 367
K ++ + + E + ++ED + L+ E + E+Q+EEE +++ ++L
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK-LQL 978
Query: 368 EASQLD-RYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
E + + K+L+++ + M Q KL E+K EER++ ++ NL + +E
Sbjct: 979 EKVTAEAKIKKLEDE----ILVMDDQNNKLSKERKLLEERIS-------DLTTNLAEEEE 1027
Query: 427 QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRM----SEFNEELNLIRS 482
+ K + KL+ ++ + L+ + ++EE E+EK K ++ S+F+E++ +++
Sbjct: 1028 K----AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 483 ELQNAGIDTHEGKRQQKRAEVLEH-----------LKRLYPDSVFGRLFDLCHPIHKKYQ 531
++ A + K++++ L LK++ + G + DL + + +
Sbjct: 1084 QI--AELKMQLAKKEEELQAALARLDDEIAQKNNALKKI--RELEGHISDLQEDLDSE-R 1138
Query: 532 LAVTKV------FGRFITAIVVASEKVAKDCI--RFLKEERAEPETFL--ALDYLDIKPI 581
A K G + A+ E + L+ +R + T L ALD + +
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSH 1197
Query: 582 NERLRELK-GCKMVIDVIKTQFPQLKKVIQFVCGN--GLVCETMEEARHIALSGPERQKT 638
+++E++ ++ + Q Q K+ + N L E + A + + G +Q+
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 639 VALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLM-----KTLR 693
L + + SD + +AR EL + + +++ + G++ K ++
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGE-RARA----ELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 694 KETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSEL-------LNIES 746
D+ + + +Q TQ L+ + + K L +E++ LQ +L N+E
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 747 QCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQK 806
L+ + + ++++++F ++ +E+ + F +EI EN+ + + ++++
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEG-KKRFQKEI--ENLTQQYEEKAAAYDKLEKT 1428
Query: 807 RLEFEKQKTRLNVQLEYSR---SHLKKKLNKIN-TLKETIQKGSEDIDHLKKAEENCLQT 862
+ +++ L V L+ R S+L+KK K + L E S+ D +AE +
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 863 VNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGK----LQKEVVSIQTS 918
+ ++ + L++ + E+ ++ E + ++ +VGK L+K +++T
Sbjct: 1489 ETKALSLARALEE-ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 919 LEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEID 978
+E+ + + L + L + D + +E+ +A Q D+ ++E E
Sbjct: 1548 MEEMKTQLEELEDE----------LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 979 YSSLKEDLKALQSDQEIEAHLRLL-----------LQQVASQEDILLKTAAPNLRALENL 1027
L+ L +++ E E R L L+ + Q D +K ++ L L
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 1028 KTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
+ FQ + ASR E +E E+ K
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAK 1690
Score = 70.1 bits (170), Expect = 1e-11
Identities = 152/785 (19%), Positives = 317/785 (40%), Gaps = 132/785 (16%)
Query: 392 QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE---QIEDHKKRI-EKLEEYTKTCMD 447
Q+ + + E + E+ L K R + + LK++++ Q+ + K + E+L+ T+ +
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 448 C------LKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRA 501
L KKQ+ E ++ E+E + ++L R ++ +D E +++ A
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 502 EVLEHLKRLYPDSVFGRLFDLC-------HPIHKKYQLAVTKVFGRFITAIVVASEKVAK 554
L+++ ++ +L D + + K+ +L ++ +T + E+ AK
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD--LTTNLAEEEEKAK 1030
Query: 555 DCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQF-PQLKKVIQFVC 613
+ L + + + E+ ++ + +K + +EL+ K ++ + F Q+ + +
Sbjct: 1031 N----LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 614 GNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDL------KYKARCWD 667
+ EE AL+ + + +A K + G SDL + AR
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDE--IAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 668 EKELKNL---------------------RDRRSQKIQELKGLMKTLRKET--DLKQIQTL 704
EK+ ++L ++ R+++ QE+ L K L +ET Q+Q +
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 705 IQGTQTRLKYSQNELEMIKK------KHLVAFYQEQSQLQSEL--------------LNI 744
Q ++ +LE K+ K+ +E + L EL +
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 745 ESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEI- 803
E+Q L + +R E +K+ K+++++ E + E E K +K +++
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEV------ESVTGMLNEAEGKAIKLAKDVA 1318
Query: 804 -------DQKRLEFEKQKTRLNV-----QLEYSRSHLKKKLNKINTLKETIQKGSEDIDH 851
D + L E+ + +LNV QLE R+ L+ +L++ K+ +++ I
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER---HIST 1375
Query: 852 LKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKE 911
L + + + + + + L++ + E + Q EE+ + +++ +LQ+E
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 912 VVSIQTSLEQKR-----LEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATI 966
+ + L+ +R LEK D + + E + S D+ E + T+A
Sbjct: 1436 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALS 1494
Query: 967 DIYEKEEAFEI----------------DYSSLKEDL-----KALQSDQEIEAHLRLLLQQ 1005
EEA E D S K+D+ + +S + +E + + Q
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 1006 VASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEAR--LCRQ------EFEQ 1057
+ ED L T LR N++ ++ +F+ A + +E R L RQ E E
Sbjct: 1555 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1614
Query: 1058 VKKRR 1062
+K+R
Sbjct: 1615 ERKQR 1619
Score = 68.2 bits (165), Expect = 5e-11
Identities = 86/401 (21%), Positives = 185/401 (46%), Gaps = 62/401 (15%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVA-----FYQEQSQLQ 738
++K L++ R+E +++ + +Q T+ R + ++NEL+ +++KH QEQ Q +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 739 SEL-LNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHV 797
+EL E + L+ +E + + E + ++++ ED
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED----------------------- 943
Query: 798 KRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKK-KLNKINTLKETIQKGSEDIDHLKKAE 856
R Q++ +R + +Q L QLE + +K +L K+ T + I+K ++I
Sbjct: 944 -RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV-TAEAKIKKLEDEI------- 994
Query: 857 ENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQ 916
+ N ++K+++L + R++ + T + EE +K + + KL+ + S+
Sbjct: 995 -LVMDDQNNKLSKERKLLEERISD------LTTNLAEEEEK----AKNLTKLKNKHESMI 1043
Query: 917 TSLEQKRLEKHNLLLDCKVQDIEII--LLSGSLDDIIEVEMGTEAESTQATIDIYEKEEA 974
+ LE RL+K + Q++E + L G D E +A+ + + + +KEE
Sbjct: 1044 SELE-VRLKKE----EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 975 FEIDYSSLKEDL----KALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTV 1030
+ + L +++ AL+ +E+E H+ L + + S+ K E L+ +
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 1031 RDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
+ + +++ D+ A+++E R R++ V K+ D T+ E
Sbjct: 1159 KTELEDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHE 1198
Score = 64.3 bits (155), Expect = 7e-10
Identities = 82/431 (19%), Positives = 189/431 (43%), Gaps = 66/431 (15%)
Query: 668 EKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHL 727
E ELK L + SQ +E L + L+ ET+L + + RL + ELE I +
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETEL---YAEAEEMRVRLAAKKQELEEILHEME 935
Query: 728 VAFYQEQ---SQLQSELLNIESQCIMLSEGIKERQRRIKEFQ-------EKIDKVEDDIF 777
+E+ QLQ+E + Q + L E ++E + ++ Q KI K+ED+I
Sbjct: 936 ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEIL 995
Query: 778 QHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINT 837
+ + +N + +++++ ++R+ L + + ++K +
Sbjct: 996 -----------VMDDQNNKLSKERKLLEERIS----------DLTTNLAEEEEKAKNLTK 1034
Query: 838 LKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKK 897
LK + +++ K EE +Q+L+ ++ A QI + + +
Sbjct: 1035 LKNKHESMISELEVRLKKEEK----------SRQELEKLKRKLEGDASDFHEQIADLQAQ 1084
Query: 898 FLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGT 957
+ ++ K ++E+ + L+ + +K+N L K++++E + L + ++ E
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALK--KIRELEGHI--SDLQEDLDSERAA 1140
Query: 958 EAESTQATIDIYEKEEAFE------IDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
++ + D+ E+ EA + +D ++ +++L+A + +QE+ + L ++ S E
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA-KREQEVTVLKKALDEETRSHEA 1199
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRK-----------EARLCRQEFEQVKK 1060
+ + + +A+E L ++F+ + + +++ E R+ Q ++V+
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 1061 RRYDLFTQCFE 1071
++ L Q E
Sbjct: 1260 KKKKLEAQVQE 1270
Score = 61.6 bits (148), Expect = 4e-09
Identities = 126/713 (17%), Positives = 298/713 (41%), Gaps = 92/713 (12%)
Query: 383 RKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYT 442
RK A QQL ++ Q+ A+ K R+ + ++K ++ + + EE
Sbjct: 810 RKAFAKRQQQLTAMKVIQRNCA---AYLKLRNWQWWRLFTKVKPLLQ-----VTRQEEEM 861
Query: 443 KTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAE 502
+ D L++ K++++ +E+++ + + S+ EE NL++ +LQ + AE
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ---------AETELYAE 912
Query: 503 VLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKE 562
E RL L ++ H + + + + G+ + A +K+A+ + L+E
Sbjct: 913 AEEMRVRLAAKK--QELEEILHEMEARLEEEEDR--GQQLQA---ERKKMAQQMLD-LEE 964
Query: 563 ERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGN--GLVCE 620
+ E E L+ ++++L+ +V+D + + +K+++ + + E
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 621 TMEEARHIALSGPERQKTVALDGTLFLK-----------SGVISGGSSDLKYKARCWDEK 669
E+A+++ + + ++ K + G +SD ++ +
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQA 1083
Query: 670 ELKNLRDRRSQKIQELKGLMKTL-----RKETDLKQIQTL------IQGTQTRLKYSQNE 718
++ L+ + ++K +EL+ + L +K LK+I+ L +Q + ++N+
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 719 LEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQ 778
E K+ +E L++EL + E +R++ + ++ +D ++
Sbjct: 1144 AEKQKRD----LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD---EETRS 1196
Query: 779 HFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTL 838
H + ++E KH + +E+ ++ +F++ K L+ ++ L+K+ +
Sbjct: 1197 HEAQ------VQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKENADLAGE 1246
Query: 839 KETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIE------ 892
+ + ++++H KK E V EL +K + R N K+Q ++E
Sbjct: 1247 LRVLGQAKQEVEHKKKKLE---AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 893 -EERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951
E K + + ++V L ++ Q L+++ +K N+ + + E L LD+ +
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 952 EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
E + E + I + + ++ + D++S E L+ + + + + L QQ +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALE--EGKKRFQKEIENLTQQYEEK-- 1418
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYD 1064
A + L+ +++ Q+ D R E+ K+R++D
Sbjct: 1419 ---------AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK-KQRKFD 1461
Score = 32.0 bits (71), Expect = 3.7
Identities = 31/196 (15%), Positives = 87/196 (44%), Gaps = 9/196 (4%)
Query: 137 QGTVESISV---KKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIA 193
QG +E++S K ++ Q E++T + E +++L++ ++ + ++ +
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Query: 194 AERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKR 253
+ ++ + EA+ Q LEE +++ + + K + + KL+ + + +R
Sbjct: 1816 KSKFKSTIAALEAKIAQ--LEE----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Query: 254 ESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLD 313
+ ++ + L RQL++ E+E + + + + + +A E+ ++++
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Query: 314 VAKKSIKDSEKQCSKQ 329
K ++ Q + Q
Sbjct: 1930 ALKSKLRGPPPQETSQ 1945
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 105 bits (261), Expect = 3e-22
Identities = 177/878 (20%), Positives = 373/878 (42%), Gaps = 128/878 (14%)
Query: 140 VESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQA 199
+E + K + + F E+I+ +L + E K +L K EE+ Q + + A++ A
Sbjct: 1053 LEKLKRKLEGDASDFHEQIA---DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109
Query: 200 KLEKEEAERYQSLLEE------LKMNKIQLQLFQLYHNEKKIHLLNTKLEHV------NR 247
+ E E + S L+E NK + Q L +++ L T+LE +
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL---GEELEALKTELEDTLDSTATQQ 1166
Query: 248 DLSVKRES------------LSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKR 295
+L KRE HE V+ +++H +L + ++ K + L++ +
Sbjct: 1167 ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK 1226
Query: 296 PQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKAL----ETELADLDAAWRSFE 351
K + + L+ L AK+ ++ +K+ Q ++++ E A+L+ +
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ 1286
Query: 352 KQIEE----------EILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQK 401
++E + + +D+ +SQL +EL ++ ++ ++ +L +L+ E+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 402 TDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKR-------IEKLEEYTKTC---MDCLKE 451
+ +++L E ++ ++ + Q+ D KK+ +E LEE K ++ L +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 452 KKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQN-AGIDTHEGKRQQKRAEVLEHLKRL 510
+ +++ D++EKTK+R+ +EL+ + +L N + ++ K+Q+K ++L K +
Sbjct: 1407 QYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1463
Query: 511 ---YPD--------------SVFGRLFDLCHPIHKKYQLAVT-KVFGRFITAIVVASEKV 552
Y D L + K +L T K+ + +V + + V
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 553 AKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDV----IKTQFP----- 603
K+ K +RA ET + ++ + + L+ + K+ ++V +K QF
Sbjct: 1524 GKNVHELEKSKRA-LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQA 1582
Query: 604 ----------QLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTL----FLKS 649
QL++ + + E +E + AL+ ++K L+G L
Sbjct: 1583 RDEQNEEKRRQLQRQL-----HEYETELEDERKQRALAAAAKKK---LEGDLKDLELQAD 1634
Query: 650 GVISGGSSDL----KYKARCWD-EKELKNLRDRRSQKIQELKGLMKTLRK-ETDLKQIQT 703
I G + K +A+ D ++EL++ R R + K K + E DL Q+Q
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694
Query: 704 LIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIK 763
+ + K + E E + ++ L + ++ LQ E +E++ L E ++E Q ++
Sbjct: 1695 DLAAAERARKQADLEKEELAEE-LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1753
Query: 764 EFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFE--------KQKT 815
+++ K + E+ E +N+ ++Q E K L + K K
Sbjct: 1754 AMSDRVRKATQQA-EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Query: 816 RLNV-QLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLK 874
+ + LE + L++++ + K+ K + D KK +E LQ +E +Q K
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKD--KKLKEILLQVEDE-RKMAEQYK 1869
Query: 875 DIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV 912
+ N+ ++++ Q+EE ++ ++ KLQ+E+
Sbjct: 1870 EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Score = 90.5 bits (223), Expect = 9e-18
Identities = 202/1021 (19%), Positives = 406/1021 (39%), Gaps = 136/1021 (13%)
Query: 149 KERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAE---RRQAKLEKEE 205
KE Q +++ L+ E + + +L E+ + KK E +A+LE+EE
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE 935
Query: 206 AERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKA 265
Q E KM + L L + E+ +LE V + +K+ E+ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ-KLQLEKVTAEAKIKKL-----EDEILV 989
Query: 266 RKKEHGMLTRQLQQTEKELKSVETLL---NQKRPQYIKAKENTSHHLKKLDVA----KKS 318
++ L+++ + E+ + + T L +K K K + +L+V +KS
Sbjct: 990 MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049
Query: 319 IKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKEL 378
++ EK K E D ++ADL A + Q+ + K+ +++ ++LD
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK----KEEELQAALARLDDEIAQ 1105
Query: 379 KEQVRKKVATMTQQLEKLQWEQKTDEERLAFEK--RRHGEVQGNLKQIKEQIED------ 430
K KK+ + + LQ + D ER A K ++ ++ L+ +K ++ED
Sbjct: 1106 KNNALKKIRELEGHISDLQ--EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 431 --------------------------HKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE 464
H+ +++++ + ++ L E+ +Q + ++
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 465 KTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEV-LEHLKRLYPDSVFGRLFDLC 523
K K + + N +L EL+ G E + ++K+ E ++ L+ D R +L
Sbjct: 1224 KNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA-ELN 1279
Query: 524 HPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINE 583
+H K Q V V G A A K+AKD + L + + + L + ++
Sbjct: 1280 DKVH-KLQNEVESVTGMLNEAEGKAI-KLAKD-VASLSSQLQDTQELLQEETRQKLNVST 1336
Query: 584 RLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDG 643
+LR+L+ + + ++ Q + + Q + E +I LS +++
Sbjct: 1337 KLRQLEEER---NSLQDQLDEEMEAKQNL-------ERHISTLNIQLSDSKKKLQDFAST 1386
Query: 644 TLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT---LRKETD--- 697
L+ G K R +KE++NL + +K L KT L++E D
Sbjct: 1387 VEALEEG-----------KKRF--QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 698 -----LKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLS 752
+Q+ + ++ Q + E + I K + E+ + ++E E++ + L+
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK----YADERDRAEAEAREKETKALSLA 1489
Query: 753 EGIKERQRRIKEFQ--EKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEF 810
++E +E + K+ K E + +++G +N+ E E + ++++ + +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG-KNVHELEKSKRALETQMEEMKTQL 1548
Query: 811 EKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQ 870
E+ + L + + L+ ++N + LK ++ + D ++ EE Q +L +
Sbjct: 1549 EELEDELQATED---AKLRLEVN-MQALKGQFERDLQARD--EQNEEKRRQLQRQLHEYE 1602
Query: 871 QQLKDIRVTQNSSAEKVQTQIEEERKKF-LAVD----------REVGKLQKEVVSIQTSL 919
+L+D R Q + A + ++E + K L D +++ KLQ ++ Q L
Sbjct: 1603 TELEDER-KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 920 EQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDY 979
E R + + K + + L L + E E QA + EKEE E
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL---EKEELAEELA 1718
Query: 980 SSLKEDLKALQSDQEIEAHLRLLLQQVASQEDIL------LKTAAPNLRALEN-LKTVRD 1032
SSL + +EA + L +++ ++ + ++ A L N L T R
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 1033 KFQESTDA---FEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNS 1089
Q++ A E KE R E E K ++ E +++ ++ R
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQ 1838
Query: 1090 A 1090
A
Sbjct: 1839 A 1839
Score = 89.0 bits (219), Expect = 3e-17
Identities = 168/873 (19%), Positives = 373/873 (42%), Gaps = 109/873 (12%)
Query: 248 DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSH 307
+L +E EN +K +++H LT + +++L++ L Y +A+E
Sbjct: 860 ELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL-------YAEAEEMRVR 912
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIEL 367
K ++ + + E + ++ED + L+ E + E+Q+EEE +++ ++L
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK-LQL 971
Query: 368 EASQLD-RYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
E + + K+L+++ + M Q KL E+K EER++ ++ NL + +E
Sbjct: 972 EKVTAEAKIKKLEDE----ILVMDDQNNKLSKERKLLEERIS-------DLTTNLAEEEE 1020
Query: 427 QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRM----SEFNEELNLIRS 482
+ K + KL+ ++ + L+ + ++EE E+EK K ++ S+F+E++ +++
Sbjct: 1021 K----AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 483 ELQNAGIDTHEGKRQQKRAEVLEH-----------LKRLYPDSVFGRLFDLCHPIHKKYQ 531
++ A + K++++ L LK++ + G + DL + + +
Sbjct: 1077 QI--AELKMQLAKKEEELQAALARLDDEIAQKNNALKKI--RELEGHISDLQEDLDSE-R 1131
Query: 532 LAVTKV------FGRFITAIVVASEKVAKDCI--RFLKEERAEPETFL--ALDYLDIKPI 581
A K G + A+ E + L+ +R + T L ALD + +
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE-ETRSH 1190
Query: 582 NERLRELK-GCKMVIDVIKTQFPQLKKVIQFVCGN--GLVCETMEEARHIALSGPERQKT 638
+++E++ ++ + Q Q K+ + N L E + A + + G +Q+
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 639 VALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLM-----KTLR 693
L + + SD + +AR EL + + +++ + G++ K ++
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGE-RARA----ELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 694 KETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSEL-------LNIES 746
D+ + + +Q TQ L+ + + K L +E++ LQ +L N+E
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 747 QCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQK 806
L+ + + ++++++F ++ +E+ + F +EI EN+ + + ++++
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEG-KKRFQKEI--ENLTQQYEEKAAAYDKLEKT 1421
Query: 807 RLEFEKQKTRLNVQLEYSR---SHLKKKLNKIN-TLKETIQKGSEDIDHLKKAEENCLQT 862
+ +++ L V L+ R S+L+KK K + L E S+ D +AE +
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 863 VNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGK----LQKEVVSIQTS 918
+ ++ + L++ + E+ ++ E + ++ +VGK L+K +++T
Sbjct: 1482 ETKALSLARALEE-ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 919 LEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEID 978
+E+ + + L + L + D + +E+ +A Q D+ ++E E
Sbjct: 1541 MEEMKTQLEELEDE----------LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 979 YSSLKEDLKALQSDQEIEAHLRLL-----------LQQVASQEDILLKTAAPNLRALENL 1027
L+ L +++ E E R L L+ + Q D +K ++ L L
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 1028 KTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
+ FQ + ASR E +E E+ K
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAK 1683
Score = 70.1 bits (170), Expect = 1e-11
Identities = 152/785 (19%), Positives = 317/785 (40%), Gaps = 132/785 (16%)
Query: 392 QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE---QIEDHKKRI-EKLEEYTKTCMD 447
Q+ + + E + E+ L K R + + LK++++ Q+ + K + E+L+ T+ +
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 448 C------LKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRA 501
L KKQ+ E ++ E+E + ++L R ++ +D E +++ A
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 502 EVLEHLKRLYPDSVFGRLFDLC-------HPIHKKYQLAVTKVFGRFITAIVVASEKVAK 554
L+++ ++ +L D + + K+ +L ++ +T + E+ AK
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD--LTTNLAEEEEKAK 1023
Query: 555 DCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQF-PQLKKVIQFVC 613
+ L + + + E+ ++ + +K + +EL+ K ++ + F Q+ + +
Sbjct: 1024 N----LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 614 GNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDL------KYKARCWD 667
+ EE AL+ + + +A K + G SDL + AR
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDE--IAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 668 EKELKNL---------------------RDRRSQKIQELKGLMKTLRKET--DLKQIQTL 704
EK+ ++L ++ R+++ QE+ L K L +ET Q+Q +
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 705 IQGTQTRLKYSQNELEMIKK------KHLVAFYQEQSQLQSEL--------------LNI 744
Q ++ +LE K+ K+ +E + L EL +
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 745 ESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEI- 803
E+Q L + +R E +K+ K+++++ E + E E K +K +++
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEV------ESVTGMLNEAEGKAIKLAKDVA 1311
Query: 804 -------DQKRLEFEKQKTRLNV-----QLEYSRSHLKKKLNKINTLKETIQKGSEDIDH 851
D + L E+ + +LNV QLE R+ L+ +L++ K+ +++ I
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER---HIST 1368
Query: 852 LKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKE 911
L + + + + + + L++ + E + Q EE+ + +++ +LQ+E
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 912 VVSIQTSLEQKR-----LEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATI 966
+ + L+ +R LEK D + + E + S D+ E + T+A
Sbjct: 1429 LDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALS 1487
Query: 967 DIYEKEEAFEI----------------DYSSLKEDL-----KALQSDQEIEAHLRLLLQQ 1005
EEA E D S K+D+ + +S + +E + + Q
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 1006 VASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEAR--LCRQ------EFEQ 1057
+ ED L T LR N++ ++ +F+ A + +E R L RQ E E
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED 1607
Query: 1058 VKKRR 1062
+K+R
Sbjct: 1608 ERKQR 1612
Score = 68.2 bits (165), Expect = 5e-11
Identities = 86/401 (21%), Positives = 185/401 (46%), Gaps = 62/401 (15%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVA-----FYQEQSQLQ 738
++K L++ R+E +++ + +Q T+ R + ++NEL+ +++KH QEQ Q +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 739 SEL-LNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHV 797
+EL E + L+ +E + + E + ++++ ED
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEED----------------------- 936
Query: 798 KRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKK-KLNKINTLKETIQKGSEDIDHLKKAE 856
R Q++ +R + +Q L QLE + +K +L K+ T + I+K ++I
Sbjct: 937 -RGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV-TAEAKIKKLEDEI------- 987
Query: 857 ENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQ 916
+ N ++K+++L + R++ + T + EE +K + + KL+ + S+
Sbjct: 988 -LVMDDQNNKLSKERKLLEERISD------LTTNLAEEEEK----AKNLTKLKNKHESMI 1036
Query: 917 TSLEQKRLEKHNLLLDCKVQDIEII--LLSGSLDDIIEVEMGTEAESTQATIDIYEKEEA 974
+ LE RL+K + Q++E + L G D E +A+ + + + +KEE
Sbjct: 1037 SELE-VRLKKE----EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 975 FEIDYSSLKEDL----KALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTV 1030
+ + L +++ AL+ +E+E H+ L + + S+ K E L+ +
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 1031 RDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFE 1071
+ + +++ D+ A+++E R R++ V K+ D T+ E
Sbjct: 1152 KTELEDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHE 1191
Score = 64.3 bits (155), Expect = 7e-10
Identities = 82/431 (19%), Positives = 189/431 (43%), Gaps = 66/431 (15%)
Query: 668 EKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHL 727
E ELK L + SQ +E L + L+ ET+L + + RL + ELE I +
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETEL---YAEAEEMRVRLAAKKQELEEILHEME 928
Query: 728 VAFYQEQ---SQLQSELLNIESQCIMLSEGIKERQRRIKEFQ-------EKIDKVEDDIF 777
+E+ QLQ+E + Q + L E ++E + ++ Q KI K+ED+I
Sbjct: 929 ARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEIL 988
Query: 778 QHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINT 837
+ + +N + +++++ ++R+ L + + ++K +
Sbjct: 989 -----------VMDDQNNKLSKERKLLEERIS----------DLTTNLAEEEEKAKNLTK 1027
Query: 838 LKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKK 897
LK + +++ K EE +Q+L+ ++ A QI + + +
Sbjct: 1028 LKNKHESMISELEVRLKKEEK----------SRQELEKLKRKLEGDASDFHEQIADLQAQ 1077
Query: 898 FLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGT 957
+ ++ K ++E+ + L+ + +K+N L K++++E + L + ++ E
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALK--KIRELEGHI--SDLQEDLDSERAA 1133
Query: 958 EAESTQATIDIYEKEEAFE------IDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
++ + D+ E+ EA + +D ++ +++L+A + +QE+ + L ++ S E
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRA-KREQEVTVLKKALDEETRSHEA 1192
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRK-----------EARLCRQEFEQVKK 1060
+ + + +A+E L ++F+ + + +++ E R+ Q ++V+
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 1061 RRYDLFTQCFE 1071
++ L Q E
Sbjct: 1253 KKKKLEAQVQE 1263
Score = 61.6 bits (148), Expect = 4e-09
Identities = 126/713 (17%), Positives = 298/713 (41%), Gaps = 92/713 (12%)
Query: 383 RKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYT 442
RK A QQL ++ Q+ A+ K R+ + ++K ++ + + EE
Sbjct: 803 RKAFAKRQQQLTAMKVIQRNCA---AYLKLRNWQWWRLFTKVKPLLQ-----VTRQEEEM 854
Query: 443 KTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAE 502
+ D L++ K++++ +E+++ + + S+ EE NL++ +LQ + AE
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ---------AETELYAE 905
Query: 503 VLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKE 562
E RL L ++ H + + + + G+ + A +K+A+ + L+E
Sbjct: 906 AEEMRVRLAAKK--QELEEILHEMEARLEEEEDR--GQQLQA---ERKKMAQQMLD-LEE 957
Query: 563 ERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGN--GLVCE 620
+ E E L+ ++++L+ +V+D + + +K+++ + + E
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 621 TMEEARHIALSGPERQKTVALDGTLFLK-----------SGVISGGSSDLKYKARCWDEK 669
E+A+++ + + ++ K + G +SD ++ +
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF-HEQIADLQA 1076
Query: 670 ELKNLRDRRSQKIQELKGLMKTL-----RKETDLKQIQTL------IQGTQTRLKYSQNE 718
++ L+ + ++K +EL+ + L +K LK+I+ L +Q + ++N+
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 719 LEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQ 778
E K+ +E L++EL + E +R++ + ++ +D ++
Sbjct: 1137 AEKQKRD----LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD---EETRS 1189
Query: 779 HFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTL 838
H + ++E KH + +E+ ++ +F++ K L+ ++ L+K+ +
Sbjct: 1190 HEAQ------VQEMRQKHAQAVEELTEQLEQFKRAK----ANLDKNKQTLEKENADLAGE 1239
Query: 839 KETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIE------ 892
+ + ++++H KK E V EL +K + R N K+Q ++E
Sbjct: 1240 LRVLGQAKQEVEHKKKKLE---AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 893 -EERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDII 951
E K + + ++V L ++ Q L+++ +K N+ + + E L LD+ +
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 952 EVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQED 1011
E + E + I + + ++ + D++S E L+ + + + + L QQ +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALE--EGKKRFQKEIENLTQQYEEK-- 1411
Query: 1012 ILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYD 1064
A + L+ +++ Q+ D R E+ K+R++D
Sbjct: 1412 ---------AAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK-KQRKFD 1454
Score = 32.0 bits (71), Expect = 3.7
Identities = 31/196 (15%), Positives = 87/196 (44%), Gaps = 9/196 (4%)
Query: 137 QGTVESISV---KKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIA 193
QG +E++S K ++ Q E++T + E +++L++ ++ + ++ +
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Query: 194 AERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKR 253
+ ++ + EA+ Q LEE +++ + + K + + KL+ + + +R
Sbjct: 1809 KSKFKSTIAALEAKIAQ--LEE----QVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Query: 254 ESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLD 313
+ ++ + L RQL++ E+E + + + + + +A E+ ++++
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Query: 314 VAKKSIKDSEKQCSKQ 329
K ++ Q + Q
Sbjct: 1923 ALKSKLRGPPPQETSQ 1938
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 102 bits (253), Expect = 3e-21
Identities = 210/1044 (20%), Positives = 435/1044 (41%), Gaps = 185/1044 (17%)
Query: 167 EYEEK-------KRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMN 219
E EEK K++L++ E + + + N+ ++ R A++ ++E + + + ++++
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALRE--KAVRVD 323
Query: 220 KIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARK----------KE 269
K++ ++ + I ++E + D V E+ + E+ ++ + KE
Sbjct: 324 KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE 383
Query: 270 HGMLTRQLQQTEKEL----KSVETLLNQKRPQYIKAKENTSHHLK---KLDVAKKSIKDS 322
+ L +L E E K +E L+ + + K++ L +L+ ++ + S
Sbjct: 384 NLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELS 443
Query: 323 EKQCSKQEDDIKAL-ETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQ 381
E ++ L + L L+ +S K +EE + +E AS++ + ++ ++
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE-LRTTVDSVEGNASKILKMEKENQR 502
Query: 382 VRKKVATM----TQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK 437
+ KKV + Q+ + LQ Q ++ + + +++ ++ ++E E K +E+
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLM----KEKAQLEKTIETLRENSERQIKILEQ 558
Query: 438 LEEYTKTCMDCLKEKKQ------------QEETLVDEIEKTKSRMSEFNEELNLIRSELQ 485
E+ + L+++ Q + + L + I++T S++S+ E I+ EL+
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 486 NAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAI 545
+ K + +RAE LE+ H + K+ +L K IT +
Sbjct: 619 HY-------KEKGERAEELENE---------------LHHLEKENELLQKK-----ITNL 651
Query: 546 VVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQL 605
+ EK I L++E +E E + + + + L K ++ ++ + QL
Sbjct: 652 KITCEK-----IEALEQENSELER-------ENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 606 KKVIQFVCGN--GLVCETMEEAR-HIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYK 662
+ + N L C +M+ A+ + E +K G LK+ ++ Y+
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 663 ARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMI 722
+ + L+ + ++KIQ+L+ ++ L E QTL Q LK S LE +
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMEN-----QTL-QKNLEELKISSKRLEQL 813
Query: 723 KKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCE 782
+K++ + QE SQL+ + +E + L + + + ++E KI +E + + +
Sbjct: 814 EKENK-SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN-KTLSK 871
Query: 783 EIGVEN---IR----EFENKHVKRQQEIDQKRLEF-------EKQKTRLNVQLEYSRSHL 828
EIG+ +R E ENK + ++ ID K L EK KT+ Q+ L
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ---QMNNDLEKL 928
Query: 829 KKKLNKINTLKETIQKGSEDIDHLKKAEENCLQT-------------------VNELMAK 869
+L KI KE + + D K E+ L++ + E
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988
Query: 870 QQQLKDIRVTQNSSAEKVQTQIEEERK------------------------------KFL 899
QQL+ T + E ++ + +EER + +
Sbjct: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
Query: 900 AVDREVGKLQKEVVSIQTSLEQKRLEKHNL---LLDCKVQDIEIILLSGSL---DDIIEV 953
V+R LQ E +++T L+Q + +NL +L + Q + + + +L + ++V
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 954 EMGT-EAEST---QATIDIYEKEEAFEIDYSSL---KEDLKALQSDQEIEAH--LRLLLQ 1004
E T ++ST + ++ + E + S+ +EDLK+L D I+ H L LL +
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY-DSLIKDHEKLELLHE 1167
Query: 1005 QVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYD 1064
+ AS+ + L+ A +NL+ + ++ D + K+ + +K +
Sbjct: 1168 RQASEYESLISKHGTLKSAHKNLEV---EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224
Query: 1065 LFTQCFEHVSISIDQIYKKLCRNN 1088
+ + H +++ + YKKLC N
Sbjct: 1225 MLLENKNHETVAAE--YKKLCGEN 1246
Score = 88.2 bits (217), Expect = 4e-17
Identities = 177/917 (19%), Positives = 387/917 (42%), Gaps = 92/917 (10%)
Query: 198 QAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTK--LEHVNRDLSVKRES 255
Q + ++E ER Q L + K + + ++ HN++ + L + D+ ++
Sbjct: 134 QCQKKEEFIERIQGLDFDTKA-AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192
Query: 256 LSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQY----IKAKENTSHHLKK 311
++ H + + EH +L + L + + + +K E+ H +
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 312 LDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQ 371
L AK I+ ++ ++ + + + EL ++ + +++ +L R + +
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE-NMNLLSDARSARMYRDE 311
Query: 372 LDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDH 431
LD +E +V K + +++ E+L + + + R+ K + + +++Q+E
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLH-DIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 432 KKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDT 491
+ R +KL E K + LK K E D K + E N L + + + + +
Sbjct: 371 RARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL-- 427
Query: 492 HEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQL---AVTKVFGRFITAIVVA 548
H G ++ + E L S+ + +L K ++ ++TK T +
Sbjct: 428 HLGWELEQISRTSE-LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV--- 483
Query: 549 SEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKV 608
+ V + + LK E+ ++ L+ + + E+ + L+ C+ + + + QL+K
Sbjct: 484 -DSVEGNASKILKMEKENQRLSKKVEILENEIVQEK-QSLQNCQNLSKDLMKEKAQLEKT 541
Query: 609 IQFVCGNG--LVCETMEEARHI-----------ALSGPERQKTVALDGTLFLKS-GVISG 654
I+ + N + +E H+ +S R K + + + +S S
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 655 GSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKY 714
S ++++ R +KEL++ +++ ++ +EL+ + L KE +L +Q T LK
Sbjct: 602 KLSKIEFEKR-QIKKELEHYKEK-GERAEELENELHHLEKENEL------LQKKITNLKI 653
Query: 715 SQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVED 774
+ ++E +++++ +E +L+ L + ++ L KE + +E E VE
Sbjct: 654 TCEKIEALEQENS-ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 775 DIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEK------------------QKTR 816
C + + + + ENK ++ ++E +K LE K + R
Sbjct: 713 ----LKCASMKMAQL-QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR 767
Query: 817 LNVQLEYSRS---HLKKKLNKINTLKETIQKGSEDI-------DHLKKAEENCLQTVNEL 866
L LE S L+ +L + +T+QK E++ + L+K ++ Q ++L
Sbjct: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Query: 867 MAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV-VSIQTSLEQKRLE 925
++QL+ AE T +EE K +++E L KE+ + ++ + K LE
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 926 KHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKED 985
K N L K I+I L +D++ ++ T+ Q D+ ++ E++ L ++
Sbjct: 888 KENKEL-VKRATIDIKTLVTLREDLVSEKLKTQ----QMNNDL--EKLTHELEKIGLNKE 940
Query: 986 LKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASR 1045
+ L +Q + +LL ++ S L+ + ALE + +EST+ + R
Sbjct: 941 -RLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALE------ARLEESTNYNQQLR 993
Query: 1046 KEARLCRQEFEQVKKRR 1062
+E + ++ +E +K+R+
Sbjct: 994 QELKTVKKNYEALKQRQ 1010
Score = 55.8 bits (133), Expect = 2e-07
Identities = 77/385 (20%), Positives = 160/385 (41%), Gaps = 49/385 (12%)
Query: 149 KERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKE-EAE 207
K+R + +S + GE + +R+ Q E + K + I ER A L+ E +A
Sbjct: 1007 KQRQDEERMVQSSPPISGEDNKWERESQ--ETTRELLKVKDRLIEVERNNATLQAEKQAL 1064
Query: 208 RYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLS---------- 257
+ Q E + N +Q Q+ L + NT L+ N L V+ +L+
Sbjct: 1065 KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQN 1124
Query: 258 ------------HHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQY--IKAKE 303
+E+++K R+ + ++ EK +E L ++ +Y + +K
Sbjct: 1125 AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK----LELLHERQASEYESLISKH 1180
Query: 304 NT--SHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHK 361
T S H K L+V + ++D Q KQ+ ++ LE L K +E++L +
Sbjct: 1181 GTLKSAH-KNLEVEHRDLEDRYNQLLKQKGQLEDLEKML-----------KVEQEKMLLE 1228
Query: 362 KRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNL 421
++ E A++ + +++ + + ++ E LQ + K + L K ++
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF 1288
Query: 422 KQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE----KTKSRMSEFNEEL 477
++KEQ + KL + +++ L+D+I+ + ++ + + E
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Query: 478 NLIRSELQNAGIDTHEGKRQQKRAE 502
+L E + +E +RQ+++ E
Sbjct: 1349 DLFHVEQRQYIDKLNELRRQKEKLE 1373
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 101 bits (252), Expect = 4e-21
Identities = 176/956 (18%), Positives = 396/956 (41%), Gaps = 107/956 (11%)
Query: 149 KERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAE---------RRQA 199
+E T+ E + S E EEK L + + D Q +++ A+ + +
Sbjct: 854 EEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKI 913
Query: 200 KLEKEEAERYQSLLEELKMN--------KIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSV 251
+LE + E + L +E +MN K++ + +L + + L K+E
Sbjct: 914 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATEN 973
Query: 252 KRESLSHH----ENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSH 307
K ++L+ + I+ KE L QQ +L++ E +N +K ++
Sbjct: 974 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDD 1033
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIEL 367
L+ KK D E+ K E D+K + + DL+ + ++Q++E + KK+D EL
Sbjct: 1034 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE----NDKQQLDERL--KKKDFEL 1087
Query: 368 EA--SQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIK 425
A ++++ + L Q++KK+ + ++E+L+ E + + A ++ ++ L++I
Sbjct: 1088 NALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS 1147
Query: 426 E-----------QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFN 474
E QIE +KKR E+ K D + Q E T +K ++E
Sbjct: 1148 ERLEEAGGATSVQIEMNKKR---EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG 1204
Query: 475 EELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAV 534
E+++ ++ Q ++ + + + + +V +++++ L +C + +
Sbjct: 1205 EQIDNLQRVKQK--LEKEKSEFKLELDDVTSNMEQII--KAKANLEKMCRTLEDQMNEHR 1260
Query: 535 TKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMV 594
+K + + + L +RA+ +T + + +L K+
Sbjct: 1261 SKA-------------EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKL- 1306
Query: 595 IDVIKTQFPQLKKVI-QFVCGNGLVCETMEEARH-IALSGPERQKTVALDGTLFLKSGVI 652
Q LK+ + + V + ++ ARH L + ++ L V+
Sbjct: 1307 --TYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAEL---QRVL 1361
Query: 653 SGGSSDL-----KYKARCWDE-KELKNLRDRRSQKIQELKGLMKTL------------RK 694
S +S++ KY+ +EL+ + + +Q++QE + ++ + R
Sbjct: 1362 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421
Query: 695 ETDLKQIQTLIQ---GTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQS---ELLNIESQC 748
+ +++ + ++ L Q + I + + + QS+L+S E ++ ++
Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Query: 749 IMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRL 808
L +E ++ F+ + ++++I E++G E + V++Q ++ +++
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEI-SDLTEQLGSSGKTIHELEKVRKQ--LEAEKM 1538
Query: 809 EFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQ-KGSEDIDHLKKAEENCLQTVNELM 867
E + LE+ + + + N +K I+ K +E + +++A+ N L+ V+ L
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQ 1598
Query: 868 AKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKH 927
R +K++ + E + +R + QK+V S+Q+ L+ +++
Sbjct: 1599 TSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLD 1658
Query: 928 NLLL--DCKVQDIEII-----LLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYS 980
+ + D ++I I+ LL L+++ V TE A ++ E E ++ +S
Sbjct: 1659 DAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHS 1718
Query: 981 ---SLKEDLKALQSD-QEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRD 1032
SL K + +D +++ + +Q+ + E+ K E LK +D
Sbjct: 1719 QNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1774
Score = 99.8 bits (247), Expect = 1e-20
Identities = 181/944 (19%), Positives = 395/944 (41%), Gaps = 130/944 (13%)
Query: 190 KNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDL 249
K+ E+ A + KEE R + LE+ + + +L+ EK + LL K + + +
Sbjct: 841 KSAEREKEMASM-KEEFTRLKEALEKSEARRKELE-------EKMVSLLQEKND-LQLQV 891
Query: 250 SVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHL 309
++++L+ E K L ++++ + L+ E + + + K ++ S
Sbjct: 892 QAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK 951
Query: 310 KKLDVAKKSIKDSEKQCSKQEDDIKALETELADLD---AAWRSFEKQIEEEILHKKRDIE 366
+ +D + ++ EK+ E+ +K L E+A LD A +K ++E D++
Sbjct: 952 RDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1011
Query: 367 LEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
E +++ + K ++ ++V + LE+ E+K R+ E+ + +++G+LK +E
Sbjct: 1012 AEEDKVNTLTKAKVKLEQQVDDLEGSLEQ---EKKV---RMDLERAKR-KLEGDLKLTQE 1064
Query: 427 QIEDHKKRIEKLEEYTKTC---MDCLKEKKQQEETLVDEIEKT----KSRMSEFNEELNL 479
I D + ++L+E K ++ L + + E+ L +++K ++R+ E EEL
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 480 IRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFG 539
R+ A ++ ++ E+ E L+ G + ++KK + K+
Sbjct: 1125 ERTA--RAKVEKLRSDLSRELEEISERLEEA------GGATSVQIEMNKKREAEFQKM-R 1175
Query: 540 RFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG-CKMVIDVI 598
R + + E A L+++ A+ L +++ + ++L + K K+ +D +
Sbjct: 1176 RDLEEATLQHEATAAA----LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1231
Query: 599 KTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSD 658
+ Q +I+ +C T+E+ + S E + D L + + + +
Sbjct: 1232 TSNMEQ---IIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND--LTSQRAKLQTENGE 1286
Query: 659 LKYKARCWDEKE--LKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQ 716
L +R DEKE + L + Q+L+ L + L +E K L+ ++
Sbjct: 1287 L---SRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN------ALAHALQSAR 1337
Query: 717 NELEMIKKKHLVAFYQEQSQLQSELLNI---------------ESQCIMLSEGIKERQR- 760
++ ++++++ Y+E+++ ++EL + E+ I +E ++E ++
Sbjct: 1338 HDCDLLREQ-----YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1392
Query: 761 ---RIKEFQEKIDKVEDDI---------FQHFCEE--IGVENIREFENKHVKRQQEIDQK 806
R++E +E ++ V Q+ E+ + VE K+Q+ D+
Sbjct: 1393 LAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKI 1452
Query: 807 RLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQ----- 861
E++++ +LE S+ + ++ LK ++ E ++ K+ +N +
Sbjct: 1453 LAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1512
Query: 862 ---------TVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV 912
T++EL ++QL+ ++ S+ E+ + +E E K L + Q E
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKIL-------RAQLEF 1565
Query: 913 VSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKE 972
I+ +E+K EK + K + ++ D ++ + E S + + +K
Sbjct: 1566 NQIKAEIERKLAEKDEEMEQAKRNHLRVV-------DSLQTSLDAETRSRNEALRVKKKM 1618
Query: 973 EA----FEIDYSSLK----EDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRAL 1024
E EI S E K ++S Q + ++ L D L + A R
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRN 1678
Query: 1025 ENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQ 1068
L+ ++ + + E SRK L QE + +R L +Q
Sbjct: 1679 NLLQAELEELRAVVEQTERSRK---LAEQELIETSERVQLLHSQ 1719
Score = 90.9 bits (224), Expect = 7e-18
Identities = 207/1052 (19%), Positives = 426/1052 (40%), Gaps = 149/1052 (14%)
Query: 86 EESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISV 145
E + E R + CSE + + + + ++ E EK K +N ++ I
Sbjct: 931 EMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIA 990
Query: 146 KKPKERTQFFEEISTSGELIGEYEEKKRKLQKAE-------EDAQFNFNKKKNIAAERRQ 198
K KE+ E + + + E+K L KA+ +D + + ++K + + +
Sbjct: 991 KLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLER 1050
Query: 199 AKLEKE-EAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVN----------R 247
AK + E + + Q + +L+ +K QL +L + +++ LN ++E +
Sbjct: 1051 AKRKLEGDLKLTQESIMDLENDKQQLD-ERLKKKDFELNALNARIEDEQALGSQLQKKLK 1109
Query: 248 DLSVKRESLSHH---ENIVKAR-KKEHGMLTRQLQQTEKELK------SVETLLNQKRPQ 297
+L + E L E +A+ +K L+R+L++ + L+ SV+ +N+KR
Sbjct: 1110 ELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA 1169
Query: 298 YIK-----AKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETEL--------ADLD 344
+ +E T H +K DS + +Q D+++ ++ +L +LD
Sbjct: 1170 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1229
Query: 345 AAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWE----- 399
+ E+ I+ + +K LE Q++ ++ E+ ++ V +T Q KLQ E
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLE-DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS 1288
Query: 400 QKTDEERLAFEKRRHGEV--QGNLKQIKEQIEDHKKRIEKLEEYTKTC---MDCLKEKKQ 454
++ DE+ + G++ L+ +K Q+E+ K L ++ D L+E+ +
Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYE 1348
Query: 455 QEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKR--AEVLEHLKRLYP 512
+E E+++ +S+ N E+ R++ + I E + K+ A+ L+ +
Sbjct: 1349 EETEAKAELQRV---LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAV- 1404
Query: 513 DSVFGRLFDLCHPIHK-KYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFL 571
++V + L H+ + ++ V A A +K ++ + L E + + E
Sbjct: 1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE--- 1461
Query: 572 ALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALS 631
E EL+ + + T+ +LK + E++E
Sbjct: 1462 -----------ESQSELESSQKEARSLSTELFKLKNAYE---------ESLEHLETFKRE 1501
Query: 632 GPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT 691
Q+ ++ D T L S + + K ++ EL++ + ++ +G K
Sbjct: 1502 NKNLQEEIS-DLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEG--KI 1558
Query: 692 LRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSE----------- 740
LR + + QI+ I + +L E+E K+ HL Q+ L +E
Sbjct: 1559 LRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 741 ------LLNIESQCIMLSEGIKERQRRIKEFQEKID----------KVEDDIFQHFCEEI 784
L +E Q + E Q+++K Q + + DD+ ++
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVE 1675
Query: 785 GVENIREFENKHVK---RQQEIDQKRLEFEKQKTRLNVQLEYSRS----HLKKKLNKINT 837
N+ + E + ++ Q E +K E E +T VQL +S++ + KKK++
Sbjct: 1676 RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDA--D 1733
Query: 838 LKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKK 897
L + + E + + AEE + + + ++LK Q++SA +E +K
Sbjct: 1734 LSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK---EQDTSA-----HLERMKKN 1785
Query: 898 FLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGT 957
+++ E I +K+L+K L+ +V+++E + +E E
Sbjct: 1786 MEQTIKDLQHRLDEAEQIALKGGKKQLQK----LEARVRELE---------NELEAEQKR 1832
Query: 958 EAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTA 1017
AES + + E+ Y + +ED K L Q++ L+L ++ Q + + A
Sbjct: 1833 NAESVKGMRK--SERRIKELTYQT-EEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQA 1889
Query: 1018 APNLRALENLKTVRDKFQESTDAFEASRKEAR 1049
NL ++ D+ +E D E+ + R
Sbjct: 1890 NTNLSKFRKVQHELDEAEERADIAESQVNKLR 1921
Score = 76.6 bits (187), Expect = 1e-13
Identities = 184/920 (20%), Positives = 378/920 (41%), Gaps = 138/920 (15%)
Query: 55 NLRVKNIQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNLVSR 114
N R+++ Q L G+ + K + + +EE EE R R + R + +SR
Sbjct: 1091 NARIEDEQAL--GSQLQKKLKELQA----RIEELEEELEAERTARAKVEKLRSD---LSR 1141
Query: 115 SVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTS-GELIGEYEEKKR 173
ELE+I L G S+ ++ K+R F+++ E ++E
Sbjct: 1142 -----ELEEIS------ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1190
Query: 174 KLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEK 233
L+K D+ ++ + +R + KLEKE++E ++ L+++ N Q+ + N +
Sbjct: 1191 ALRKKHADSVAELGEQID-NLQRVKQKLEKEKSE-FKLELDDVTSN--MEQIIKAKANLE 1246
Query: 234 KIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKK---EHGMLTRQL--------QQTEK 282
K + T + +N S E+ ++ R K E+G L+RQL Q T
Sbjct: 1247 K--MCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRG 1304
Query: 283 ELKSVETLLNQKRP--QYIKAKENTSHHLKKL----DVAKKSIKDSEKQCSKQEDDIKAL 336
+L + L + KR + +KAK +H L+ D+ ++ ++ + ++ + +
Sbjct: 1305 KLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKA 1364
Query: 337 ETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKL 396
+E+A + + Q EE+ K+ + A +L +E E V K +++ + +L
Sbjct: 1365 NSEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQEAEEAVEAVNAKCSSLEKTKHRL 1421
Query: 397 QWEQK---TDEERLAFEKRRHGEVQGNLKQI----KEQIEDHKKRIEKLEEYTKTCMDCL 449
Q E + D ER + Q N +I K++ E+ + +E ++ ++ L
Sbjct: 1422 QNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1481
Query: 450 KEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKR 509
+ K E ++ +E K EE++ + +L ++G HE ++ +K+ LE K
Sbjct: 1482 FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQ---LEAEKM 1538
Query: 510 LYPDSVFGRLFDLCHPIHK--KYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEP 567
++ L H K + QL ++ + E++ + L R
Sbjct: 1539 ELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHL---RVVD 1595
Query: 568 ETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARH 627
+LD + + NE LR K KM D+ + + IQ N + E ++ +
Sbjct: 1596 SLQTSLD-AETRSRNEALRVKK--KMEGDLNEME-------IQLSHANRMAAEAQKQVK- 1644
Query: 628 IALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKG 687
+L + + LD + + DLK + + + +++EL+
Sbjct: 1645 -SLQSLLKDTQIQLDDAV--------RANDDLKENIAIVERR-----NNLLQAELEELRA 1690
Query: 688 LMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQ 747
+++ + L + + + + +L +SQN + +KK + A + SQLQ+E+ +
Sbjct: 1691 VVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDA---DLSQLQTEVEEAVQE 1747
Query: 748 C--------------IMLSEGIKERQ--------------RRIKEFQEKIDKVEDDIFQH 779
C M++E +K+ Q + IK+ Q ++D+ E +
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Query: 780 FCEEIG--VENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINT 837
+++ +RE EN+ ++ +Q+ + + ++ ++ R +L Y +K L ++
Sbjct: 1808 GKKQLQKLEARVRELENE-LEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQD 1866
Query: 838 LKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKK 897
L + +Q + K+ E + N T S KVQ +++E ++
Sbjct: 1867 LVDKLQL---KVKAYKRQAEEAEEQAN--------------TNLSKFRKVQHELDEAEER 1909
Query: 898 FLAVDREVGKLQKEVVSIQT 917
+ +V KL+ + I T
Sbjct: 1910 ADIAESQVNKLRAKSRDIGT 1929
Score = 70.1 bits (170), Expect = 1e-11
Identities = 134/689 (19%), Positives = 287/689 (41%), Gaps = 102/689 (14%)
Query: 128 VKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFN 187
VKA+N L ++S R Q+ EE EL +R L KA +
Sbjct: 1323 VKAKNALAH--ALQSARHDCDLLREQYEEETEAKAEL-------QRVLSKANSEVAQWRT 1373
Query: 188 KKKNIAAERRQA--KLEKEEAERYQSLLEELK-MNKIQLQLFQLYHN-EKKIHLLNTKLE 243
K + A +R + + +K+ A+R Q E ++ +N L + H + +I L +E
Sbjct: 1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433
Query: 244 HVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKE 303
N + + + + I+ K+++ +L+ ++KE +S+ T L + + Y ++ E
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
Query: 304 NTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEE-EILHKK 362
+ ++ ++ I D +Q I LE L+A + +EE E +
Sbjct: 1494 HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEH 1553
Query: 363 RDIELEASQLDRYKELKEQVRKKVATMTQQLEK---------------LQWEQKTDEERL 407
+ ++ +QL+ + ++K ++ +K+A +++E+ L E ++ E L
Sbjct: 1554 EEGKILRAQLE-FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL 1612
Query: 408 AFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTK 467
+K+ ++G+L +++ Q+ + + ++ K+ LK+ + Q + V + K
Sbjct: 1613 RVKKK----MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1668
Query: 468 SRMSEFNEELNLIRSELQ--NAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHP 525
++ NL+++EL+ A ++ E R+ E++E +R+ L H
Sbjct: 1669 ENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV----------QLLHS 1718
Query: 526 IHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERL 585
+ + K ++ + E+ ++C EE+A+ D + E L
Sbjct: 1719 QNTSL-INQKKKMDADLSQLQTEVEEAVQECRN--AEEKAKKA------ITDAAMMAEEL 1769
Query: 586 RELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTL 645
++ + ++ +K Q K +Q ++EA IAL G ++Q
Sbjct: 1770 KKEQDTSAHLERMKKNMEQTIKDLQ---------HRLDEAEQIALKGGKKQLQ------- 1813
Query: 646 FLKSGVISGGSSDLKYKARCWDEKELKN-LRDRRSQKIQELKGLMKTLRKETDLKQIQTL 704
K +AR +EL+N L + + + +KG+ K+ R+ +K++
Sbjct: 1814 --------------KLEARV---RELENELEAEQKRNAESVKGMRKSERR---IKELTYQ 1853
Query: 705 IQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKE 764
+ + L Q+ ++ ++ K V Y+ Q++ E N LS+ ++ Q + E
Sbjct: 1854 TEEDRKNLLRLQDLVDKLQLK--VKAYKRQAEEAEEQANTN-----LSK-FRKVQHELDE 1905
Query: 765 FQEKIDKVEDDI--FQHFCEEIGVENIRE 791
+E+ D E + + +IG + + E
Sbjct: 1906 AEERADIAESQVNKLRAKSRDIGTKGLNE 1934
Score = 62.0 bits (149), Expect = 3e-09
Identities = 76/380 (20%), Positives = 175/380 (46%), Gaps = 35/380 (9%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSE--- 740
++K L+K+ +E ++ ++ + L+ S+ + +++K +V+ QE++ LQ +
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEK-MVSLLQEKNDLQLQVQA 893
Query: 741 ----LLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVE---NIREFE 793
L + E +C L + + + ++KE E++ ED+ EE+ E R+ E
Sbjct: 894 EQDNLADAEERCDQLIKNKIQLEAKVKEMNERL---EDE------EEMNAELTAKKRKLE 944
Query: 794 NKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLK 853
++ + +++ID L K + + + + +K ++ L E I K +++ L+
Sbjct: 945 DECSELKRDIDDLELTLAKVEKEKHA----TENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 854 KAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVV 913
+A + L + K L +V + ++ +E+E+K + ++R KL+ ++
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 914 SIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATID--IYEK 971
Q S+ +K L K +D E+ L+ ++D E +G++ + + I E
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIED--EQALGSQLQKKLKELQARIEEL 1118
Query: 972 EEAFEIDYSSLKEDLKALQSD--QEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKT 1029
EE E + ++ + ++ L+SD +E+E + L++ + ++ N + +
Sbjct: 1119 EEELEAERTA-RAKVEKLRSDLSRELE-EISERLEEAGGATSVQIEM---NKKREAEFQK 1173
Query: 1030 VRDKFQESTDAFEASRKEAR 1049
+R +E+T EA+ R
Sbjct: 1174 MRRDLEEATLQHEATAAALR 1193
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 101 bits (252), Expect = 4e-21
Identities = 212/1045 (20%), Positives = 437/1045 (41%), Gaps = 186/1045 (17%)
Query: 167 EYEEK-------KRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMN 219
E EEK K++L++ E + + + N+ ++ R A++ ++E + + + ++++
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALRE--KAVRVD 323
Query: 220 KIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARK----------KE 269
K++ ++ + I ++E + D V E+ + E+ ++ + KE
Sbjct: 324 KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKE 383
Query: 270 HGMLTRQLQQTEKEL----KSVETLLNQKRPQYIKAKENTSHHLK---KLDVAKKSIKDS 322
+ L +L E E K +E L+ + + K++ L +L+ ++ + S
Sbjct: 384 NLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELS 443
Query: 323 EKQCSKQEDDIKAL-ETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQ 381
E ++ L + L L+ +S K +EE + +E AS++ + ++ ++
Sbjct: 444 EAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE-LRTTVDSVEGNASKILKMEKENQR 502
Query: 382 VRKKVATM----TQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK 437
+ KKV + Q+ + LQ Q ++ + + +++ ++ ++E E K +E+
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLM----KEKAQLEKTIETLRENSERQIKILEQ 558
Query: 438 LEEYTKTCMDCLKEKKQ------------QEETLVDEIEKTKSRMSEFNEELNLIRSELQ 485
E+ + L+++ Q + + L + I++T S++S+ E I+ EL+
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 486 NAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAI 545
+ K + +RAE LE+ H + K+ +L K IT +
Sbjct: 619 HY-------KEKGERAEELENE---------------LHHLEKENELLQKK-----ITNL 651
Query: 546 VVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQL 605
+ EK I L++E +E E + + + + L K ++ ++ + QL
Sbjct: 652 KITCEK-----IEALEQENSELER-------ENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 606 KKVIQFVCGN--GLVCETMEEAR-HIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYK 662
+ + N L C +M+ A+ + E +K G LK+ ++ Y+
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 663 ARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMI 722
+ + L+ + ++KIQ+L+ ++ L E QTL Q LK S LE +
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMEN-----QTL-QKNLEELKISSKRLEQL 813
Query: 723 KKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCE 782
+K++ + QE SQL+ + +E + L + + + ++E KI +E + + +
Sbjct: 814 EKENK-SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN-KTLSK 871
Query: 783 EIGVEN---IR----EFENKHVKRQQEIDQKRLEF-------EKQKTRLNVQLEYSRSHL 828
EIG+ +R E ENK + ++ ID K L EK KT+ Q+ L
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ---QMNNDLEKL 928
Query: 829 KKKLNKINTLKETIQKGSEDIDH-------------LKKAEENCLQTVNELMAK------ 869
+L KI KE + + D LKK+ E + + L A+
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988
Query: 870 -QQQLKDIRVTQNSSAEKVQTQIEEERK------------------------------KF 898
QQL+ T + E ++ + +EER +
Sbjct: 989 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048
Query: 899 LAVDREVGKLQKEVVSIQTSLEQKRLEKHNL---LLDCKVQDIEIILLSGSL---DDIIE 952
+ V+R LQ E +++T L+Q + +NL +L + Q + + + +L + ++
Sbjct: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
Query: 953 VEMGT-EAEST---QATIDIYEKEEAFEIDYSSL---KEDLKALQSDQEIEAH--LRLLL 1003
VE T ++ST + ++ + E + S+ +EDLK+L D I+ H L LL
Sbjct: 1109 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY-DSLIKDHEKLELLH 1167
Query: 1004 QQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRY 1063
++ AS+ + L+ A +NL+ + ++ D + K+ + +K +
Sbjct: 1168 ERQASEYESLISKHGTLKSAHKNLEV---EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1224
Query: 1064 DLFTQCFEHVSISIDQIYKKLCRNN 1088
+ + H +++ + YKKLC N
Sbjct: 1225 KMLLENKNHETVAAE--YKKLCGEN 1247
Score = 85.9 bits (211), Expect = 2e-16
Identities = 173/826 (20%), Positives = 331/826 (40%), Gaps = 149/826 (18%)
Query: 156 EEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEE 215
E GE E E + L+K E Q K + + E E ER L++
Sbjct: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 216 LKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTR 275
++ + FQL EK+ N++L+ N +L ESL K M
Sbjct: 678 -TLDSFKNLTFQLESLEKE----NSQLDEENLELRRNVESL-----------KCASMKMA 721
Query: 276 QLQQTEKELKSVETLLNQKRPQYIKAKENTSHHL----KKLDVAKKSIKDSEKQCSKQED 331
QLQ KEL+S + L +K + +KA + L + LD+ + ++ + + +K+
Sbjct: 722 QLQLENKELESEKEQL-KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK-- 778
Query: 332 DIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQ 391
I+ LE+EL DL+ ++ +K +EE + KR +LE +E Q+ K + +
Sbjct: 779 -IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQE-TSQLEKDKKQLEK 836
Query: 392 QLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKE 451
+ ++L+ + + + L + G ++ K + ++I +K+ +L+E K + +K
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 452 KKQQEETLV---DEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLK 508
+TLV +++ K + + N +L + EL+ G++ E L H +
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN----------KERLLHDE 946
Query: 509 RLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPE 568
+ DS +Y+L +K+ ++ + EK+A E R E
Sbjct: 947 QSTDDS--------------RYKLLESKLESTLKKSLEIKEEKIA------ALEARLEES 986
Query: 569 TFLALDYLDIKPINERLR-ELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARH 627
T N++LR ELK K + +K + +E R
Sbjct: 987 T----------NYNQQLRQELKTVKKNYEALK--------------------QRQDEERM 1016
Query: 628 IALSGP--------ERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRS 679
+ S P ER+ L +K +I ++ +A +++ LK +
Sbjct: 1017 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQA---EKQALKTQLKQLE 1073
Query: 680 QKIQELKGLMKTLRKET-DLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQL- 737
+ L+ + L+++T L++ T +Q +L+ + L + + +QL
Sbjct: 1074 TQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTL----NSQSTSLMNQNAQLL 1129
Query: 738 --QSELLNIESQCIMLSEGIKE---------------RQRRIKEFQEKIDKVEDDIFQHF 780
QS L N I E +K +R+ E++ I K H
Sbjct: 1130 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
Query: 781 CEEIGVENIREFENKHVKRQQEID--QKRLEFEKQKTRL------NVQLEYSR------- 825
E+ ++ + N+ +K++ +++ +K L+ E++K L V EY +
Sbjct: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR 1249
Query: 826 -SHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQ-NSS 883
+H +L K + +T K + + + K E+ L+ + +Q Q DI T+ N+
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1309
Query: 884 AE---KVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEK 926
E +++ +EEE + L ++Q ++ +T LEQ K
Sbjct: 1310 CELLSQLKGNLEEENRHLL------DQIQTLMLQNRTLLEQNMESK 1349
Score = 85.1 bits (209), Expect = 4e-16
Identities = 175/917 (19%), Positives = 384/917 (41%), Gaps = 91/917 (9%)
Query: 198 QAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTK--LEHVNRDLSVKRES 255
Q + ++E ER Q L + K + + ++ HN++ + L + D+ ++
Sbjct: 134 QCQKKEEFIERIQGLDFDTKA-AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKN 192
Query: 256 LSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQY----IKAKENTSHHLKK 311
++ H + + EH +L + L + + + +K E+ H +
Sbjct: 193 MALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVE 252
Query: 312 LDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQ 371
L AK I+ ++ ++ + + + EL ++ + +++ +L R + +
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE-NMNLLSDARSARMYRDE 311
Query: 372 LDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDH 431
LD +E +V K + +++ E+L + + + R+ K + + +++Q+E
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLH-DIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 432 KKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDT 491
+ R +KL E K + LK K E D K + E N L + + + + +
Sbjct: 371 RARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL-- 427
Query: 492 HEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQL---AVTKVFGRFITAIVVA 548
H G ++ + E L S+ + +L K ++ ++TK T +
Sbjct: 428 HLGWELEQISRTSE-LSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV--- 483
Query: 549 SEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKV 608
+ V + + LK E+ ++ L+ + + E+ + L+ C+ + + + QL+K
Sbjct: 484 -DSVEGNASKILKMEKENQRLSKKVEILENEIVQEK-QSLQNCQNLSKDLMKEKAQLEKT 541
Query: 609 IQFVCGNG--LVCETMEEARHI-----------ALSGPERQKTVALDGTLFLKS-GVISG 654
I+ + N + +E H+ +S R K + + + +S S
Sbjct: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS 601
Query: 655 GSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKY 714
S ++++ R +KEL++ +++ ++ +EL+ + L KE +L +Q T LK
Sbjct: 602 KLSKIEFEKR-QIKKELEHYKEK-GERAEELENELHHLEKENEL------LQKKITNLKI 653
Query: 715 SQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVED 774
+ ++E +++++ +E +L+ L + ++ L KE + +E E VE
Sbjct: 654 TCEKIEALEQENS-ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
Query: 775 DIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEK------------------QKTR 816
C + + + + ENK ++ ++E +K LE K + R
Sbjct: 713 ----LKCASMKMAQL-QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR 767
Query: 817 LNVQLEYSRS---HLKKKLNKINTLKETIQKGSEDI-------DHLKKAEENCLQTVNEL 866
L LE S L+ +L + +T+QK E++ + L+K ++ Q ++L
Sbjct: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827
Query: 867 MAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV-VSIQTSLEQKRLE 925
++QL+ AE T +EE K +++E L KE+ + ++ + K LE
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 926 KHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKED 985
K N L K I+I L +D++ ++ T+ Q D+ ++ E++ L ++
Sbjct: 888 KENKEL-VKRATIDIKTLVTLREDLVSEKLKTQ----QMNNDL--EKLTHELEKIGLNKE 940
Query: 986 LKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASR 1045
++ +LL ++ S L+ + ALE + +EST+ + R
Sbjct: 941 RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE------ARLEESTNYNQQLR 994
Query: 1046 KEARLCRQEFEQVKKRR 1062
+E + ++ +E +K+R+
Sbjct: 995 QELKTVKKNYEALKQRQ 1011
Score = 55.8 bits (133), Expect = 2e-07
Identities = 77/385 (20%), Positives = 160/385 (41%), Gaps = 49/385 (12%)
Query: 149 KERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKE-EAE 207
K+R + +S + GE + +R+ Q E + K + I ER A L+ E +A
Sbjct: 1008 KQRQDEERMVQSSPPISGEDNKWERESQ--ETTRELLKVKDRLIEVERNNATLQAEKQAL 1065
Query: 208 RYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLS---------- 257
+ Q E + N +Q Q+ L + NT L+ N L V+ +L+
Sbjct: 1066 KTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQN 1125
Query: 258 ------------HHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQY--IKAKE 303
+E+++K R+ + ++ EK +E L ++ +Y + +K
Sbjct: 1126 AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK----LELLHERQASEYESLISKH 1181
Query: 304 NT--SHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHK 361
T S H K L+V + ++D Q KQ+ ++ LE L K +E++L +
Sbjct: 1182 GTLKSAH-KNLEVEHRDLEDRYNQLLKQKGQLEDLEKML-----------KVEQEKMLLE 1229
Query: 362 KRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNL 421
++ E A++ + +++ + + ++ E LQ + K + L K ++
Sbjct: 1230 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF 1289
Query: 422 KQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE----KTKSRMSEFNEEL 477
++KEQ + KL + +++ L+D+I+ + ++ + + E
Sbjct: 1290 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1349
Query: 478 NLIRSELQNAGIDTHEGKRQQKRAE 502
+L E + +E +RQ+++ E
Sbjct: 1350 DLFHVEQRQYIDKLNELRRQKEKLE 1374
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 97.4 bits (241), Expect = 7e-20
Identities = 195/920 (21%), Positives = 387/920 (42%), Gaps = 145/920 (15%)
Query: 159 STSGEL---IGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEE 215
S+ GEL I + +EK + L +EDA ++ K + E E ER ++
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM------MTEKERSNVVITR 375
Query: 216 LKMNKIQLQLFQLYHN--EKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGML 273
+ K ++ + HN + KIH+ + + + RE + E + K+E+G+L
Sbjct: 376 M---KDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM---EAEIAHLKQENGIL 429
Query: 274 TRQLQQTEKELKSVETL-LNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDD 332
+ T +L+S ++ LN+ R Y + + KL + K++E+ ++
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQ---- 485
Query: 333 IKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLD---RYKELKEQVRKKVATM 389
L+ +L + + W + I +KR E EA+Q D ++ + +V+ + +
Sbjct: 486 ---LKVQLQEAERRWEEVQSYI------RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL 536
Query: 390 T------QQLE-KLQWEQKTDEERLAFEKRRHGEVQGNLKQ---IKEQIEDHKKRIEK-- 437
T QQLE +L +++++R+ E+ +VQ L+Q +K QI+ +I
Sbjct: 537 TDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
Query: 438 -----LEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELN---LIRSELQ---- 485
EE K + K+ KQ E++L E ++ S+ E + N L+++E+Q
Sbjct: 597 SASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA 656
Query: 486 ---NAGIDTHEGKRQQKRAEVLEHLKRLYPDSV----------FGRLFDLCHPIHKKYQL 532
HE ++ Q+ V + RL + + F L D + + Q
Sbjct: 657 LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
Query: 533 AVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG-- 590
T V + +V EK CI+ E+ E L + + E L ++
Sbjct: 717 LQTLVSEQPNKDVVEQMEK----CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
Query: 591 ---CKMVIDVIKTQFPQ---------LKKVIQFVCGNGLVCETMEEARHIALSGPERQKT 638
K V D+ Q Q LKKVI G E + EA + ++ ++KT
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA--NKEKT 830
Query: 639 VALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQ------KIQELKGLMKTL 692
V DLK + + E E+ N++ ++Q K+QEL+ L+K
Sbjct: 831 V-----------------QDLKQEIKALKE-EIGNVQLEKAQQLSITSKVQELQNLLK-- 870
Query: 693 RKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKH--LVAFYQEQSQLQSELLNIESQCIM 750
KE + ++ +++ + L + L+ +++++ L A QE +Q + + SQ
Sbjct: 871 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 930
Query: 751 LSEGIKERQRRIKEFQEKIDKVEDDIFQ--HFCEEIGVENIREFENKHVKRQQEIDQKRL 808
L +KE++ +K + + + E D+ +++ EN + F+++ + +Q+ Q+
Sbjct: 931 LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN-KLFKSQIEQLKQQNYQQAS 989
Query: 809 EFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQ----KGSEDIDHLKKAEENCLQTVN 864
F + L V E + + N++++LK+ ++ K +E ++ E + +
Sbjct: 990 SFPPHEELLKVISEREK-EISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLK 1048
Query: 865 ELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRL 924
+L K + V N S + E++ K+ +A G E V + ++
Sbjct: 1049 KLFPK------VSVPSNLSYGEWLHGFEKKAKECMA-----GTSGSEEVKVLEHKLKEAD 1097
Query: 925 EKHNLL-LDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEA---FEIDYS 980
E H LL L+C+ + G L +++ E E + + + E + + ++
Sbjct: 1098 EMHTLLQLECEKYKSVLAETEGILQ---KLQRSVEQEENKWKVKVDESHKTIKQMQSSFT 1154
Query: 981 SLKEDLKALQSDQEIEAHLR 1000
S +++L+ L+S+ + +LR
Sbjct: 1155 SSEQELERLRSENKDIENLR 1174
Score = 76.3 bits (186), Expect = 2e-13
Identities = 177/814 (21%), Positives = 329/814 (40%), Gaps = 150/814 (18%)
Query: 153 QFFEEIS--TSGELIGE-----YEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAK----L 201
QF +I+ TS ++ E EK +++++ E+ ++ + E + + L
Sbjct: 587 QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL 646
Query: 202 EKEEAERYQSLLEELKMNKIQLQLFQ--LYHNEKKIHLLNTKLEHVNRDLSVKRESLSHH 259
K E ++ Q+L E +L+ Q +Y + KI LL +L+H ++S K E
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKIL 703
Query: 260 ENIVKARKKEHGMLT----------------RQLQQTEKELKSVETLLNQKRPQYIKAKE 303
+ KA K E L + +Q+ +++LK+VE LL Q +E
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
Query: 304 NTSHHLKKLDVAKKSIKDSEKQCSKQEDDI------KALETELADLDAAWRSFEKQIEEE 357
+ + K ++D + +KQ D + + L+ + + D +S E+ +E E
Sbjct: 764 ELNAIRTENSSLTKEVQDLK---AKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
Query: 358 ILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEV 417
+L + K LKE++ QLEK Q T + + E+
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNV------QLEKAQQLSITSKVQ---------EL 865
Query: 418 QGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE-------KTKSRM 470
Q LK +EQ+ K +E+ E+ L++ +++ E+L ++ K S
Sbjct: 866 QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 471 SEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKY 530
S+F EEL ++ E +N + KR E + LK D + K
Sbjct: 926 SQF-EELEIVLKEKEN----------ELKRLEAM--LKERESD------------LSSKT 960
Query: 531 QLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG 590
QL V K+ K I LK++ + + +K I+ER +E+ G
Sbjct: 961 QLLQD----------VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISG 1010
Query: 591 CKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSG 650
+D +K +K E ++ + L E K LF K
Sbjct: 1011 LWNELDSLKDAVEHQRKKNN---------ERQQQVEAVELEAKEVLKK------LFPKVS 1055
Query: 651 VISGGSSDLKYKARCWD-EKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQ 709
V S+L Y EK+ K S +E+K L L KE D ++ TL+Q
Sbjct: 1056 V----PSNLSYGEWLHGFEKKAKECMAGTSGS-EEVKVLEHKL-KEAD--EMHTLLQ--- 1104
Query: 710 TRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKI 769
LE K K ++A + + LQ ++E + + E + IK+ Q
Sbjct: 1105 ---------LECEKYKSVLA--ETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSF 1153
Query: 770 DKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLK 829
E ++ + E +EN+R E +H++ + E + E +++ ++ ++ L
Sbjct: 1154 TSSEQELERLRSENKDIENLRR-EREHLEMELE------KAEMERSTYVTEVRELKAQLN 1206
Query: 830 KKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQT 889
+ L K+ T + QK + D L KA+++ L+ + + K D V +NS +T
Sbjct: 1207 ETLTKLRTEQNERQKVAGD---LHKAQQS-LELIQSKIVK--AAGDTTVIENSDVSP-ET 1259
Query: 890 QIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKR 923
+ E+ +++++ V +LQ+ + ++ L +++
Sbjct: 1260 ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEK 1293
Score = 72.8 bits (177), Expect = 2e-12
Identities = 170/856 (19%), Positives = 353/856 (41%), Gaps = 126/856 (14%)
Query: 251 VKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLK 310
+K +S + + K+ K E L QLQ+ +K L +V+ + + + + +
Sbjct: 308 LKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
Query: 311 KLDVAKKSIKDS----EKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDI- 365
+ +V +KD EK+ + ++ I E + ++ +Q+E EI H K++
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 427
Query: 366 -----------ELEASQLDRYKELKEQVRKKVATMTQQLEKLQWE--QKTDEERLAFEKR 412
+LE+ Q +L++ + V +T++ KLQ E QK + E+ A
Sbjct: 428 ILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA---- 483
Query: 413 RHGEVQGNLKQIKEQIEDHKKRIEKLEEYT-KTCMDCLKEKKQQEETLVDEIEKTKSRMS 471
Q+K Q+++ ++R E+++ Y K + ++ + V + + +S S
Sbjct: 484 ---------TQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHS 534
Query: 472 EFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGR--LFDLCHPIHKK 529
+ + L + + +L+ + E +QKR E L+ D + L H +
Sbjct: 535 KLTDTL-VSKQQLEQRLMQLMES--EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQ 591
Query: 530 YQLAVT-KVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLR-E 587
+ V + ++ +K K L ER + T + DI+ +N L+ E
Sbjct: 592 IAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER-DRLTSKEEELKDIQNMNFLLKAE 650
Query: 588 LKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFL 647
++ + + + +L+K+ Q V +EE +S + + D L
Sbjct: 651 VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKAL 710
Query: 648 KSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQG 707
KS +++ E+ K++ ++ + IQE K+ LK ++ L++
Sbjct: 711 KS--------EVQKLQTLVSEQPNKDVVEQMEKCIQE---------KDEKLKTVEELLET 753
Query: 708 TQTRLKYSQNELEMIKKKH--LVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEF 765
++ + EL I+ ++ L Q+ Q++ ++ S L + I E+ +IK
Sbjct: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
Query: 766 QEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSR 825
+E + E ++ + +E V+++++ E K +K +EI +LE + Q+ + +++ +
Sbjct: 814 EELL---EAELLKVANKEKTVQDLKQ-EIKALK--EEIGNVQLE-KAQQLSITSKVQELQ 866
Query: 826 SHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAE 885
+ LK K ++NT+K +++ +D+ + K ++ + L A Q++ + + SSA
Sbjct: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA- 925
Query: 886 KVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSG 945
+Q EE E+V + E KRLE +L + D+
Sbjct: 926 ---SQFEE----------------LEIVLKEKENELKRLEA---MLKERESDL------- 956
Query: 946 SLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ 1005
+ TQ D+ ++ + F+ LK+ + Q H LL +
Sbjct: 957 -------------SSKTQLLQDVQDENKLFKSQIEQLKQ--QNYQQASSFPPHEELL--K 999
Query: 1006 VASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDL 1065
V S+ + K + L++LK DA E RK+ +Q+ E V+ ++
Sbjct: 1000 VISERE---KEISGLWNELDSLK----------DAVEHQRKKNNERQQQVEAVELEAKEV 1046
Query: 1066 FTQCFEHVSISIDQIY 1081
+ F VS+ + Y
Sbjct: 1047 LKKLFPKVSVPSNLSY 1062
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 97.1 bits (240), Expect = 9e-20
Identities = 190/907 (20%), Positives = 397/907 (43%), Gaps = 123/907 (13%)
Query: 143 ISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLE 202
+S K +++ + EE++ E+ E EEK++++ + + Q + K R++A+ E
Sbjct: 1529 LSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQ---EEHKWARIHRKRARAE 1585
Query: 203 KEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENI 262
K+ A+ + L +E + K+ + QL E+K+ K+ +R+++ + E
Sbjct: 1586 KKRAQEERKLAQEEE--KLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEET 1643
Query: 263 VKARKKEHGMLTRQLQQTEKELKSV-------ETLLNQKRPQYIKAKENTSHHLKKLDVA 315
+ R ++ +L Q K+L E L +K + + K + +++L
Sbjct: 1644 LAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
Query: 316 KKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEE-EILHKKRDIELEASQLDR 374
++++ EK+ +++ ++ LE ++ +L +W+ E EE +++ +K+ + E L
Sbjct: 1704 EQNLDWQEKELAQE---LEELEWDMEEL--SWKEEELNQEEGKLVEEKKKLAEEEEALAW 1758
Query: 375 YKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKR 434
+E + K+A + L + + + +E++ E+ R G + L + K ++ ++R
Sbjct: 1759 QREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRER 1818
Query: 435 -IEKLEEYTKTCMDCLKEKK--QQEETLVDEIEKTKSRMSE--FNEELNLIRSELQNAGI 489
I +EE TK M ++K Q+++ L E EK R +N+E L S+ Q +
Sbjct: 1819 WINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKE-RLTHSKKQLVQV 1877
Query: 490 DTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVAS 549
G + A+V E L + ++V I KK +LA T+ +V
Sbjct: 1878 KNKLGMFNKILAQVEEKLTQ-EKETV----------IKKKEKLAETE------KKLVQVE 1920
Query: 550 EKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKV- 608
+ +AK +E+ A+ + LAL+ K + + + L+G + K ++K++
Sbjct: 1921 DSLAKK-----QEKLAQEKMKLALE----KAMVQGKKRLRGELDIAKEEKALNLEMKRLA 1971
Query: 609 ---IQFVCGNGLVC--ETMEEARHIALSGPERQ---KTVAL--------DGTLFLKSGVI 652
++ V G + ET E +R ++ E++ + ++L D L ++ I
Sbjct: 1972 EEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEI 2031
Query: 653 SGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETD-LKQIQTLIQGTQTR 711
+ G + R + + + K + R + I++ + L K K LK +Q L T+
Sbjct: 2032 AKGKLEFTRGQRIFVQGQRKLAKASR-KLIKKRESLSKEPAKLNKILKALQKL---TRDE 2087
Query: 712 LKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDK 771
K +Q E++M K K A + ++ +L E ++ + SE E + K+ K K
Sbjct: 2088 RKLTQEEIKMTKMKR--ALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRK 2145
Query: 772 VEDDIFQHFCEEIGVENIREFENKHVKRQQEI---DQKRLEFEKQKTRLNVQLEYSRSHL 828
+ + + + +E E + E E+K ++ E+ D++ E+++ + R
Sbjct: 2146 LANKMRRMINKE---EKMTEEESKLARKHSEVILDDEEEGGIEEEEV---IPFLKRRWRK 2199
Query: 829 KKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQ 888
+K+ + + KE ++++ + E ++EL KQ+ L SS E+ +
Sbjct: 2200 RKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDEL-EKQESL--------SSEEEEE 2250
Query: 889 TQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLD 948
+ EEER++ + E + ++E E+K++EK
Sbjct: 2251 REEEEEREEEEVREEEEERKEEE------EGEEKQVEK---------------------- 2282
Query: 949 DIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVAS 1008
E E + + + ++ EKEE FE + E+ SD+E E L ++V
Sbjct: 2283 ---EEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDR 2339
Query: 1009 QEDILLK 1015
+++IL K
Sbjct: 2340 EKEILKK 2346
Score = 90.9 bits (224), Expect = 7e-18
Identities = 141/756 (18%), Positives = 315/756 (41%), Gaps = 86/756 (11%)
Query: 166 GEYEEKKRKL----QKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELK---- 217
G++ +K+ L +K ++A+ K+K +A + + E+E+ + L E+K
Sbjct: 1635 GKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILA 1694
Query: 218 --MNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTR 275
+ ++ + L EK++ +LE +LS K E L+ E + KK+
Sbjct: 1695 QKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEE 1754
Query: 276 QLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKA 335
L ++L ET L Q+ I+ KE + H K+ + + E++ ++ + +
Sbjct: 1755 ALAWQREKLSEEETKLAQEEELLIQEKEKLAQH-------KEKMPEEEERLGRKREQLIE 1807
Query: 336 LETELADLDAAWRSFEKQIEEE--ILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQL 393
+ +LA W + +++ + IL++K+++ E L + KE Q ++ + ++L
Sbjct: 1808 KKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERL 1867
Query: 394 EKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKK 453
+ + + +L + +V+ L Q KE + K+++ + E+ D L +K+
Sbjct: 1868 THSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQ 1927
Query: 454 QQ----------EETLVDEIEKTKSRMSEFNEE--LNLIRSELQNAGIDTHEGKRQQKRA 501
++ E+ +V ++ + + EE LNL L + EGK +
Sbjct: 1928 EKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKG 1987
Query: 502 EVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLK 561
E E ++ V LF+ + +K L ++ + + ++AK + F +
Sbjct: 1988 ETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRI-------LAMEESEIAKGKLEFTR 2040
Query: 562 EERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCET 621
+R + L K I +R + + + +L K+++ L T
Sbjct: 2041 GQRIFVQGQRKLAKASRKLIKKR-----------ESLSKEPAKLNKILK-----ALQKLT 2084
Query: 622 MEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRR--S 679
+E + E K + LF+K +S S L K + EK + +D + +
Sbjct: 2085 RDERKLTQ----EEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLA 2140
Query: 680 QKIQELKGLMKTL-RKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQ 738
+K ++L M+ + KE + + ++ + + + E I+++ ++ F + + + +
Sbjct: 2141 RKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKR 2200
Query: 739 SELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVK 798
E + S + E + + F E+++ + D++ + E + E E E + +
Sbjct: 2201 KEAKRGDKPKEKFSSQVDEVESE-EHFSEEMESLLDELEKQ--ESLSSEEEEEREEEEER 2257
Query: 799 RQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKG------------- 845
++E+ ++ E ++++ Q+E KKK K KE +Q+
Sbjct: 2258 EEEEVREEEEERKEEEEGEEKQVEKEEEEKKKK--KKEKKKEEVQEKEEVFEEKEEIMSE 2315
Query: 846 --SEDIDHLKKAEENC-----LQTVNELMAKQQQLK 874
+E + ++ EE+C + E++ K++Q K
Sbjct: 2316 EETESLSDEEEEEESCSLEEEVDREKEILKKEKQFK 2351
Score = 80.1 bits (196), Expect = 1e-14
Identities = 87/370 (23%), Positives = 172/370 (46%), Gaps = 23/370 (6%)
Query: 146 KKPKERTQFFEEISTSGELIGEYEEKKRKLQKAE---EDAQFNFNKKKNIAAERRQAKLE 202
K + + FE + E I +E++ ++++E +F ++ + +R+ AK
Sbjct: 1997 KMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKAS 2056
Query: 203 KEEAERYQSLLEE-LKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHEN 261
++ ++ +SL +E K+NKI L +L +E+K+ K+ + R L VK LS ++
Sbjct: 2057 RKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQS 2116
Query: 262 IVKARKKEHGMLTRQLQQTEKEL-KSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIK 320
+ ++ + +L + EK+L + L N+ R K ++ T K + I
Sbjct: 2117 KLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVIL 2176
Query: 321 DSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKE 380
D E++ +E+++ + L WR +E + E +SQ+D E +E
Sbjct: 2177 DDEEEGGIEEEEV------IPFLKRRWRK-----RKEAKRGDKPKEKFSSQVDEV-ESEE 2224
Query: 381 QVRKKVATMTQQLEKLQ-WEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLE 439
+++ ++ +LEK + + +EER E+R EV+ ++ KE+ E +K++EK E
Sbjct: 2225 HFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEE 2284
Query: 440 EYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQK 499
E K KEKK++E +E+ + K + E +L E + E ++K
Sbjct: 2285 EEKKKKK---KEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREK 2341
Query: 500 RAEVLEHLKR 509
E+L+ K+
Sbjct: 2342 --EILKKEKQ 2349
Score = 71.6 bits (174), Expect = 4e-12
Identities = 193/964 (20%), Positives = 403/964 (41%), Gaps = 177/964 (18%)
Query: 138 GTVESISVKKPKERTQFFEEIS-TSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAER 196
G E+ + K ++ F E + T G+ I + EEKK QK+ + +K + ER
Sbjct: 1359 GLEETQVILKKGKKVIFLEPGNVTMGKEISKKEEKKT-FQKSPKQG------RKAVQKER 1411
Query: 197 RQAKLEK----------EEAERYQSLLEELKMNKIQLQLFQ------------------- 227
+ K+++ EE E +L E++ + +L + +
Sbjct: 1412 KVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVH 1471
Query: 228 -----------------LYHNEKKIHLLNTKL----EHVNRDLSVKRESLSH-HENIVKA 265
L E+K+H KL E + D +K E EN++ +
Sbjct: 1472 GETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSS 1531
Query: 266 RKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQ 325
+ KE + E+E V +K Q + + + K + +K + +EK+
Sbjct: 1532 KSKEQQYKDEEEVTLEEE---VSREGEEKEQQVTEEQRHIQEEHKWARIHRKRAR-AEKK 1587
Query: 326 CSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKK 385
+++E + E +LA + E+++ + + +D A ++ + +E + ++
Sbjct: 1588 RAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQR 1647
Query: 386 VATMTQQLEKL---------QWEQ-KTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRI 435
++Q+ EKL +WE+ +EE+LA + + EV+ L Q E++ ++ +
Sbjct: 1648 GEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNL 1707
Query: 436 EKLEEYTKTCMDCL-----------KEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSEL 484
+ E+ ++ L +E Q+E LV+E K +++E E L R +L
Sbjct: 1708 DWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEE----KKKLAEEEEALAWQREKL 1763
Query: 485 --QNAGIDTHEGKRQQKRAEVLEHLKRL-YPDSVFGRLFDLCHPIHKKYQLAVTKVFGRF 541
+ + E Q++ ++ +H +++ + GR + I KK +LA + R+
Sbjct: 1764 SEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKRE--QLIEKKMKLAQKR--ERW 1819
Query: 542 ITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQ 601
I ++ E I + K+ A+ + LA + + + +R L K + K Q
Sbjct: 1820 INSM---EELTKNKMILYQKKNLAQEKKNLAQEK---EKLAQRKENLLYNKERLTHSKKQ 1873
Query: 602 FPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKY 661
Q+K + N ++ + E+ + ++TV +K
Sbjct: 1874 LVQVKNKLGMF--NKILAQVEEKL-------TQEKETV-------------------IKK 1905
Query: 662 KARCWD-EKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELE 720
K + + EK+L + D ++K ++L +++ L + ++QG K + EL+
Sbjct: 1906 KEKLAETEKKLVQVEDSLAKKQEKL------AQEKMKLALEKAMVQGK----KRLRGELD 1955
Query: 721 MIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHF 780
+ K++ A E +L E + + LS+G R Q K+ +VE ++F+
Sbjct: 1956 IAKEEK--ALNLEMKRLAEEKMRLVEGKETLSKGETPETSR----QRKMTQVEQELFERK 2009
Query: 781 CEEIGVENIREFENKHVKRQQ-EIDQKRLEF----------EKQKTRLNVQLEYSRSHLK 829
E I E++ + ++ EI + +LEF +++ + + +L R L
Sbjct: 2010 LSL--EEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLS 2067
Query: 830 KKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQL----KDIRVTQNSSAE 885
K+ K+N + + +QK + D L + E + L K+++L + + + +E
Sbjct: 2068 KEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSE 2127
Query: 886 KVQTQIEEERKKFLAVDREVGKLQKEVVSIQ---TSLEQKRLEKHN-LLLDCK----VQD 937
K ++++ ++ KK R++ + +++ + T E K KH+ ++LD + +++
Sbjct: 2128 K-RSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEE 2186
Query: 938 IEII-LLSGSLDDIIEVEMGTE-AESTQATIDIYEKEEAFEIDYSSLKEDL---KALQSD 992
E+I L E + G + E + +D E EE F + SL ++L ++L S+
Sbjct: 2187 EEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSE 2246
Query: 993 QEIE 996
+E E
Sbjct: 2247 EEEE 2250
Score = 43.9 bits (102), Expect = 0.001
Identities = 63/333 (18%), Positives = 140/333 (42%), Gaps = 73/333 (21%)
Query: 160 TSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAK-----LEKEEAERYQSLLE 214
T G+ I + + +RKL KA K+++++ E + L+K + + E
Sbjct: 2039 TRGQRI--FVQGQRKLAKASRKL---IKKRESLSKEPAKLNKILKALQKLTRDERKLTQE 2093
Query: 215 ELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLT 274
E+KM K++ LF E+++ + +KL+ D S KR L+ E + ++++
Sbjct: 2094 EIKMTKMKRALFV---KERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKM 2150
Query: 275 RQLQQTEKELKSVETLLNQKRPQYI--------------------------------KAK 302
R++ E+++ E+ L +K + I K K
Sbjct: 2151 RRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPK 2210
Query: 303 ENTSHHLKKLD---------------------VAKKSIKDSEKQCSKQEDDIKALETELA 341
E S + +++ ++ + ++ E++ ++E++++ E E
Sbjct: 2211 EKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERK 2270
Query: 342 DLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQK 401
+ + EKQ+E+E KK+ + + + + +E +E +K M+++ + +++
Sbjct: 2271 EEE---EGEEKQVEKEEEEKKK--KKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEE 2325
Query: 402 TDEERLAFEKR--RHGEVQGNLKQIKEQIEDHK 432
+EE + E+ R E+ KQ K Q + K
Sbjct: 2326 EEEESCSLEEEVDREKEILKKEKQFKLQEQRRK 2358
Score = 43.5 bits (101), Expect = 0.001
Identities = 48/205 (23%), Positives = 96/205 (46%), Gaps = 24/205 (11%)
Query: 179 EEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLL 238
EE+ F K++ +R++AK + E++ S ++E++ + H +++ L
Sbjct: 2185 EEEEVIPFLKRR--WRKRKEAKRGDKPKEKFSSQVDEVESEE---------HFSEEMESL 2233
Query: 239 NTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQY 298
+LE K+ESLS E + R++E ++++ E+E K E ++ +
Sbjct: 2234 LDELE--------KQESLSSEEE--EEREEEEEREEEEVREEEEERKEEEEGEEKQVEKE 2283
Query: 299 IKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEI 358
+ K+ KK +V +K EK+ E++ ++L E + ++ E E+EI
Sbjct: 2284 EEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEI 2343
Query: 359 LHKKRDIELEASQLDRYKELKEQVR 383
L K++ +L Q R K L+ + R
Sbjct: 2344 LKKEKQFKL---QEQRRKSLRGRER 2365
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 97.1 bits (240), Expect = 9e-20
Identities = 207/1004 (20%), Positives = 418/1004 (41%), Gaps = 166/1004 (16%)
Query: 159 STSGEL---IGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEE 215
S+ GEL I + +EK + L +EDA ++ K + E E ER ++
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM------MTEKERSNVVITR 375
Query: 216 LKMNKIQLQLFQLYHN--EKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGML 273
+ K ++ + HN + KIH+ + + + RE + E + K+E+G+L
Sbjct: 376 M---KDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM---EAEIAHLKQENGIL 429
Query: 274 TRQLQQTEKELKSVETL-LNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDD 332
+ T +L+S ++ LN+ R Y + + KL + K++E+ ++
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQ---- 485
Query: 333 IKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLD---RYKELKEQVRKKVATM 389
L+ +L + + W + I +KR E EA+Q D ++ + +V+ + +
Sbjct: 486 ---LKVQLQEAERRWEEVQSYI------RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL 536
Query: 390 T------QQLE-KLQWEQKTDEERLAFEKRRHGEVQGNLKQ---IKEQIEDHKKRIEK-- 437
T QQLE +L +++++R+ E+ +VQ L+Q +K QI+ +I
Sbjct: 537 TDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
Query: 438 -----LEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELN---LIRSELQ---- 485
EE K + K+ KQ E++L E ++ S+ E + N L+++E+Q
Sbjct: 597 SASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA 656
Query: 486 ---NAGIDTHEGKRQQKRAEVLEHLKRLYPDSV----------FGRLFDLCHPIHKKYQL 532
HE ++ Q+ V + RL + + F L D + + Q
Sbjct: 657 LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
Query: 533 AVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG-- 590
T V + +V EK CI+ E+ E L + + E L ++
Sbjct: 717 LQTLVSEQPNKDVVEQMEK----CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
Query: 591 ---CKMVIDVIKTQFPQ---------LKKVIQFVCGNGLVCETMEEARHIALSGPERQKT 638
K V D+ Q Q LKKVI G E + EA + ++ ++KT
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA--NKEKT 830
Query: 639 VALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQ------KIQELKGLMKTL 692
V DLK + + E E+ N++ ++Q K+QEL+ L+K
Sbjct: 831 V-----------------QDLKQEIKALKE-EIGNVQLEKAQQLSITSKVQELQNLLK-- 870
Query: 693 RKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKH--LVAFYQEQSQLQSELLNIESQCIM 750
KE + ++ +++ + L + L+ +++++ L A QE +Q + + SQ
Sbjct: 871 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 930
Query: 751 LSEGIKERQRRIKEFQEKIDKVEDDIFQ--HFCEEIGVENIREFENKHVKRQQEIDQKRL 808
L +KE++ +K + + + E D+ +++ EN + F+++ + +Q+ Q+
Sbjct: 931 LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN-KLFKSQIEQLKQQNYQQAS 989
Query: 809 EFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETI-----------QKGSEDIDHLKKAEE 857
F + L V E + + N++++LK+ + +K E ++ L E+
Sbjct: 990 SFPPHEELLKVISEREK-EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 858 NCLQTVNEL-MAKQQQLKDIRVTQNSSAEKVQTQI---------------EEERKKFLAV 901
VN+ +QQQ++ + + +K+ ++ E++ K+ +A
Sbjct: 1049 MLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA- 1107
Query: 902 DREVGKLQKEVVSIQTSLEQKRLEKHNLL-LDCKVQDIEIILLSGSLDDIIEVEMGTEAE 960
G E V + ++ E H LL L+C+ + G L +++ E E
Sbjct: 1108 ----GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ---KLQRSVEQE 1160
Query: 961 STQATIDIYEKEEA---FEIDYSSLKEDLKALQSDQEIEAHLRL---LLQQVASQEDILL 1014
+ + + E + + ++S +++L+ L+S+ + +LR L+ + ++
Sbjct: 1161 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMER 1220
Query: 1015 KTAAPNLRALENLKT-VRDKFQESTDAFEASRKEARLCRQEFEQ 1057
T +R L++L T ++ K +S +E L + + +
Sbjct: 1221 STYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNE 1264
Score = 92.8 bits (229), Expect = 2e-18
Identities = 195/956 (20%), Positives = 399/956 (41%), Gaps = 131/956 (13%)
Query: 128 VKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFN 187
+K +N ++ + + + K+ + + L+ E EK KLQ+ E
Sbjct: 422 LKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEV------- 474
Query: 188 KKKNIAAERRQAKLEKEEAER-YQSLLEELKMNKIQLQLFQ------LYHNEKKIHLLNT 240
+KKN Q K++ +EAER ++ + ++ + + Q E ++ L++
Sbjct: 475 QKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHS 534
Query: 241 KLEHVNRDLSVKRESLSHH-----ENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKR 295
KL D V ++ L E+ K KE L Q+Q ++ ++++ + Q
Sbjct: 535 KLT----DTLVSKQQLEQRLMQLMESEQKRVNKEES-LQMQVQDILEQNEALKAQIQQFH 589
Query: 296 PQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIE 355
Q I A+ + S ++L K I + +KQ + ED + + L E
Sbjct: 590 SQ-IAAQTSASVLAEELH---KVIAEKDKQIKQTEDSLASERDRLTSK-----------E 634
Query: 356 EEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQ--KTDEERLAFEKRR 413
EE+ +DI+ L + + + + A +LEK+Q K D+ RL E+ +
Sbjct: 635 EEL----KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ 690
Query: 414 HGEVQGNLKQIK---EQIEDHKKRIEKLE---------EYTKTCMDCLKEKKQQEETLVD 461
H E+ +++ K +Q + K ++KL+ + + C++EK ++ +T+ +
Sbjct: 691 H-EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE 749
Query: 462 EIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKR----AEVLEHLKRLYPDSVFG 517
+E +++ EELN IR+E + + + K +Q A ++E LK++ + G
Sbjct: 750 LLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKD-G 808
Query: 518 RLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDC---IRFLKEERAEPETFLALD 574
++ + + + + KV + EK +D I+ LKEE + A
Sbjct: 809 KI----KSVEELLEAELLKVANK---------EKTVQDLKQEIKALKEEIGNVQLEKAQQ 855
Query: 575 YLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPE 634
+ E LKG + ++ +K + +K + G + ++E
Sbjct: 856 LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL---ANTGKWLQDLQEENES------ 906
Query: 635 RQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRK 694
LK+ V +LK + +EL+ + + +++ L+ ++K +
Sbjct: 907 ------------LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK--ER 952
Query: 695 ETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQL--QSELLNIESQCIMLS 752
E+DL L+Q Q K ++++E +K+++ YQ+ S ELL + S+
Sbjct: 953 ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQN----YQQASSFPPHEELLKVISEREKEI 1008
Query: 753 EGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGV-----ENIREFENKHVK-RQQEIDQK 806
G+ +K+ E K +D+ + E + + +++ NK K RQQ+++
Sbjct: 1009 SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV 1068
Query: 807 RLEFEKQKTRL--NVQLEYSRSHLKKKLNKINTLKETIQ--KGSEDIDHLKKAEENCLQT 862
LE ++ +L V + + S+ + KE + GSE++ L+ + +
Sbjct: 1069 ELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEM 1128
Query: 863 VNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQ- 921
L + ++ K + +K+Q +E+E K+ E K K++ S TS EQ
Sbjct: 1129 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE 1188
Query: 922 -KRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYS 980
+RL N +DIE + + +E+E ST T K+ E+
Sbjct: 1189 LERLRSEN-------KDIENLRREREHLE-MELEKAEMERSTYVTEVRELKDLLTELQKK 1240
Query: 981 SLKEDLKALQSDQE---IEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDK 1033
+A++ ++E ++A L L ++ ++++ K A +A ++L+ ++ K
Sbjct: 1241 LDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1296
Score = 72.8 bits (177), Expect = 2e-12
Identities = 172/875 (19%), Positives = 360/875 (41%), Gaps = 122/875 (13%)
Query: 251 VKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLK 310
+K +S + + K+ K E L QLQ+ +K L +V+ + + + + +
Sbjct: 308 LKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
Query: 311 KLDVAKKSIKDS----EKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRD-- 364
+ +V +KD EK+ + ++ I E + ++ +Q+E EI H K++
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 427
Query: 365 ----------IELEASQLDRYKELKEQVRKKVATMTQQLEKLQWE--QKTDEERLAFEKR 412
+LE+ Q +L++ + V +T++ KLQ E QK + E+ A
Sbjct: 428 ILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA---- 483
Query: 413 RHGEVQGNLKQIKEQIEDHKKRIEKLEEY-TKTCMDCLKEKKQQEETLVDEIEKTKSRMS 471
Q+K Q+++ ++R E+++ Y K + ++ + V + + +S S
Sbjct: 484 ---------TQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHS 534
Query: 472 EFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGR--LFDLCHPIHKK 529
+ + L + + +L+ + E +QKR E L+ D + L H +
Sbjct: 535 KLTDTL-VSKQQLEQRLMQLMES--EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQ 591
Query: 530 YQLAVT-KVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLR-E 587
+ V + ++ +K K L ER + T + DI+ +N L+ E
Sbjct: 592 IAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER-DRLTSKEEELKDIQNMNFLLKAE 650
Query: 588 LKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFL 647
++ + + + +L+K+ Q V +EE +S + + D L
Sbjct: 651 VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKAL 710
Query: 648 KSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQG 707
K S+++ E+ K++ ++ + IQE K+ LK ++ L++
Sbjct: 711 K--------SEVQKLQTLVSEQPNKDVVEQMEKCIQE---------KDEKLKTVEELLET 753
Query: 708 TQTRLKYSQNELEMIKKKH--LVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEF 765
++ + EL I+ ++ L Q+ Q++ ++ S L + I E+ +IK
Sbjct: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
Query: 766 QEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSR 825
+E + E ++ + +E V+++++ E K +K +EI +LE + Q+ + +++ +
Sbjct: 814 EELL---EAELLKVANKEKTVQDLKQ-EIKALK--EEIGNVQLE-KAQQLSITSKVQELQ 866
Query: 826 SHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAE 885
+ LK K ++NT+K +++ +D+ + K ++ + L A Q++ + + SSA
Sbjct: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA- 925
Query: 886 KVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSG 945
+Q EE E+V + E KRLE +L + D+
Sbjct: 926 ---SQFEE----------------LEIVLKEKENELKRLE---AMLKERESDL------- 956
Query: 946 SLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ 1005
+ TQ D+ ++ + F+ LK+ + Q H LL +
Sbjct: 957 -------------SSKTQLLQDVQDENKLFKSQIEQLKQ--QNYQQASSFPPHEELL--K 999
Query: 1006 VASQEDILLKTAAPNLRALENL-----KTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
V S+ + + L +L++ K D +++ +A EA ++ + + + K
Sbjct: 1000 VISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSK 1059
Query: 1061 RRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLS 1095
R Q E V + ++ KKL S + LS
Sbjct: 1060 ER----QQQVEAVELEAKEVLKKLFPKVSVPSNLS 1090
Score = 64.7 bits (156), Expect = 5e-10
Identities = 164/817 (20%), Positives = 322/817 (39%), Gaps = 156/817 (19%)
Query: 153 QFFEEIS--TSGELIGE-----YEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAK----L 201
QF +I+ TS ++ E EK +++++ E+ ++ + E + + L
Sbjct: 587 QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL 646
Query: 202 EKEEAERYQSLLEELKMNKIQLQLFQ--LYHNEKKIHLLNTKLEHVNRDLSVKRESLSHH 259
K E ++ Q+L E +L+ Q +Y + KI LL +L+H ++S K E
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKIL 703
Query: 260 ENIVKARKKEHGMLT----------------RQLQQTEKELKSVETLLNQKRPQYIKAKE 303
+ KA K E L + +Q+ +++LK+VE LL Q +E
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
Query: 304 NTSHHLKKLDVAKKSIKDSEKQCSKQEDDI------KALETELADLDAAWRSFEKQIEEE 357
+ + K ++D + +KQ D + + L+ + + D +S E+ +E E
Sbjct: 764 ELNAIRTENSSLTKEVQDLK---AKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
Query: 358 ILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEV 417
+L + K LKE++ QLEK Q T + + E+
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNV------QLEKAQQLSITSKVQ---------EL 865
Query: 418 QGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE-------KTKSRM 470
Q LK +EQ+ K +E+ E+ L++ +++ E+L ++ K S
Sbjct: 866 QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 471 SEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKY 530
S+F EEL ++ E +N + KR E + LK D + K
Sbjct: 926 SQF-EELEIVLKEKEN----------ELKRLEAM--LKERESD------------LSSKT 960
Query: 531 QLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG 590
QL V K+ K I LK++ + + +K I+ER +E+ G
Sbjct: 961 QLLQD----------VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISG 1010
Query: 591 CKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSG 650
+D +K +K N + E EA AL T +
Sbjct: 1011 LWNELDSLKDAVEHQRKK------NNDLREKNWEAME------------ALASTEKMLQD 1052
Query: 651 VISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQ- 709
++ S + + + E E K + + K+ L K+ + + GT
Sbjct: 1053 KVNKTSKERQQQVEAV-ELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1111
Query: 710 -TRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEK 768
+K +++L+ + H + LQ E +S + +EGI ++ +R E +E
Sbjct: 1112 SEEVKVLEHKLKEADEMHTL--------LQLECEKYKS-VLAETEGILQKLQRSVEQEEN 1162
Query: 769 IDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLE------FEKQKTRLNVQLE 822
KV+ D + I++ ++ +QE+++ R E +++ L ++LE
Sbjct: 1163 KWKVKVDESH--------KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1214
Query: 823 YSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNS 882
+ + ++ LK+ + + + +D + +E + + ++L ++ N
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTELQKKLD----------DSYSEAVRQNEELNLLKAQLNE 1264
Query: 883 SAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSL 919
+ K++T+ E +K V ++ K Q+ + IQ+ +
Sbjct: 1265 TLTKLRTEQNERQK----VAGDLHKAQQSLELIQSKI 1297
Score = 60.8 bits (146), Expect = 8e-09
Identities = 89/442 (20%), Positives = 194/442 (43%), Gaps = 68/442 (15%)
Query: 115 SVYIAELEKIGIIVKAQNCL-VFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKR 173
+V + + +++ I K Q + +G E ++ K + ++++ +G+ + + +E+
Sbjct: 847 NVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE-KDLANTGKWLQDLQEENE 905
Query: 174 KLQK-AEEDAQFNFNKKKNIAAERRQAKL---EKE-EAERYQSLLEELKMN-KIQLQLFQ 227
L+ +E AQ N K+ + A++ + ++ EKE E +R +++L+E + + + QL Q
Sbjct: 906 SLKAHVQEVAQHNL-KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ 964
Query: 228 LYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSV 287
+E K L +++E + + + S HE ++K + +++ EL S+
Sbjct: 965 DVQDENK--LFKSQIEQLKQQNYQQASSFPPHEELLKVISERE----KEISGLWNELDSL 1018
Query: 288 ETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQ-EDDIKALETELADL--- 343
+ + +R + +E ++ L +K ++D + SK+ + ++A+E E ++
Sbjct: 1019 KDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1078
Query: 344 ------------DAAW-RSFEKQIEEEILHKKRDIEL--------EASQLDRYKELKEQV 382
W FEK+ +E + E+ EA ++ +L+ +
Sbjct: 1079 LFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEK 1138
Query: 383 RKKVATMTQQ-LEKLQ---------WEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHK 432
K V T+ L+KLQ W+ K DE ++ + +Q E++
Sbjct: 1139 YKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSS--EQELERLRSEN 1196
Query: 433 KRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEF--------------NEELN 478
K IE L + L++ + + T V E+ + K ++E NEELN
Sbjct: 1197 KDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELN 1256
Query: 479 LIRSELQN--AGIDTHEGKRQQ 498
L++++L + T + +RQ+
Sbjct: 1257 LLKAQLNETLTKLRTEQNERQK 1278
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 97.1 bits (240), Expect = 9e-20
Identities = 207/1004 (20%), Positives = 418/1004 (41%), Gaps = 166/1004 (16%)
Query: 159 STSGEL---IGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEE 215
S+ GEL I + +EK + L +EDA ++ K + E E ER ++
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM------MTEKERSNVVITR 375
Query: 216 LKMNKIQLQLFQLYHN--EKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGML 273
+ K ++ + HN + KIH+ + + + RE + E + K+E+G+L
Sbjct: 376 M---KDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM---EAEIAHLKQENGIL 429
Query: 274 TRQLQQTEKELKSVETL-LNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDD 332
+ T +L+S ++ LN+ R Y + + KL + K++E+ ++
Sbjct: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQ---- 485
Query: 333 IKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLD---RYKELKEQVRKKVATM 389
L+ +L + + W + I +KR E EA+Q D ++ + +V+ + +
Sbjct: 486 ---LKVQLQEAERRWEEVQSYI------RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL 536
Query: 390 T------QQLE-KLQWEQKTDEERLAFEKRRHGEVQGNLKQ---IKEQIEDHKKRIEK-- 437
T QQLE +L +++++R+ E+ +VQ L+Q +K QI+ +I
Sbjct: 537 TDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
Query: 438 -----LEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELN---LIRSELQ---- 485
EE K + K+ KQ E++L E ++ S+ E + N L+++E+Q
Sbjct: 597 SASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA 656
Query: 486 ---NAGIDTHEGKRQQKRAEVLEHLKRLYPDSV----------FGRLFDLCHPIHKKYQL 532
HE ++ Q+ V + RL + + F L D + + Q
Sbjct: 657 LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
Query: 533 AVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG-- 590
T V + +V EK CI+ E+ E L + + E L ++
Sbjct: 717 LQTLVSEQPNKDVVEQMEK----CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTEN 772
Query: 591 ---CKMVIDVIKTQFPQ---------LKKVIQFVCGNGLVCETMEEARHIALSGPERQKT 638
K V D+ Q Q LKKVI G E + EA + ++ ++KT
Sbjct: 773 SSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA--NKEKT 830
Query: 639 VALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQ------KIQELKGLMKTL 692
V DLK + + E E+ N++ ++Q K+QEL+ L+K
Sbjct: 831 V-----------------QDLKQEIKALKE-EIGNVQLEKAQQLSITSKVQELQNLLK-- 870
Query: 693 RKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKH--LVAFYQEQSQLQSELLNIESQCIM 750
KE + ++ +++ + L + L+ +++++ L A QE +Q + + SQ
Sbjct: 871 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 930
Query: 751 LSEGIKERQRRIKEFQEKIDKVEDDIFQ--HFCEEIGVENIREFENKHVKRQQEIDQKRL 808
L +KE++ +K + + + E D+ +++ EN + F+++ + +Q+ Q+
Sbjct: 931 LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN-KLFKSQIEQLKQQNYQQAS 989
Query: 809 EFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETI-----------QKGSEDIDHLKKAEE 857
F + L V E + + N++++LK+ + +K E ++ L E+
Sbjct: 990 SFPPHEELLKVISEREK-EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 858 NCLQTVNEL-MAKQQQLKDIRVTQNSSAEKVQTQI---------------EEERKKFLAV 901
VN+ +QQQ++ + + +K+ ++ E++ K+ +A
Sbjct: 1049 MLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA- 1107
Query: 902 DREVGKLQKEVVSIQTSLEQKRLEKHNLL-LDCKVQDIEIILLSGSLDDIIEVEMGTEAE 960
G E V + ++ E H LL L+C+ + G L +++ E E
Sbjct: 1108 ----GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ---KLQRSVEQE 1160
Query: 961 STQATIDIYEKEEA---FEIDYSSLKEDLKALQSDQEIEAHLRL---LLQQVASQEDILL 1014
+ + + E + + ++S +++L+ L+S+ + +LR L+ + ++
Sbjct: 1161 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMER 1220
Query: 1015 KTAAPNLRALENLKT-VRDKFQESTDAFEASRKEARLCRQEFEQ 1057
T +R L++L T ++ K +S +E L + + +
Sbjct: 1221 STYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNE 1264
Score = 92.8 bits (229), Expect = 2e-18
Identities = 195/956 (20%), Positives = 399/956 (41%), Gaps = 131/956 (13%)
Query: 128 VKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFN 187
+K +N ++ + + + K+ + + L+ E EK KLQ+ E
Sbjct: 422 LKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEV------- 474
Query: 188 KKKNIAAERRQAKLEKEEAER-YQSLLEELKMNKIQLQLFQ------LYHNEKKIHLLNT 240
+KKN Q K++ +EAER ++ + ++ + + Q E ++ L++
Sbjct: 475 QKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHS 534
Query: 241 KLEHVNRDLSVKRESLSHH-----ENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKR 295
KL D V ++ L E+ K KE L Q+Q ++ ++++ + Q
Sbjct: 535 KLT----DTLVSKQQLEQRLMQLMESEQKRVNKEES-LQMQVQDILEQNEALKAQIQQFH 589
Query: 296 PQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIE 355
Q I A+ + S ++L K I + +KQ + ED + + L E
Sbjct: 590 SQ-IAAQTSASVLAEELH---KVIAEKDKQIKQTEDSLASERDRLTSK-----------E 634
Query: 356 EEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQ--KTDEERLAFEKRR 413
EE+ +DI+ L + + + + A +LEK+Q K D+ RL E+ +
Sbjct: 635 EEL----KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ 690
Query: 414 HGEVQGNLKQIK---EQIEDHKKRIEKLE---------EYTKTCMDCLKEKKQQEETLVD 461
H E+ +++ K +Q + K ++KL+ + + C++EK ++ +T+ +
Sbjct: 691 H-EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE 749
Query: 462 EIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKR----AEVLEHLKRLYPDSVFG 517
+E +++ EELN IR+E + + + K +Q A ++E LK++ + G
Sbjct: 750 LLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKD-G 808
Query: 518 RLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDC---IRFLKEERAEPETFLALD 574
++ + + + + KV + EK +D I+ LKEE + A
Sbjct: 809 KI----KSVEELLEAELLKVANK---------EKTVQDLKQEIKALKEEIGNVQLEKAQQ 855
Query: 575 YLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPE 634
+ E LKG + ++ +K + +K + G + ++E
Sbjct: 856 LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL---ANTGKWLQDLQEENES------ 906
Query: 635 RQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRK 694
LK+ V +LK + +EL+ + + +++ L+ ++K +
Sbjct: 907 ------------LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK--ER 952
Query: 695 ETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQL--QSELLNIESQCIMLS 752
E+DL L+Q Q K ++++E +K+++ YQ+ S ELL + S+
Sbjct: 953 ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQN----YQQASSFPPHEELLKVISEREKEI 1008
Query: 753 EGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGV-----ENIREFENKHVK-RQQEIDQK 806
G+ +K+ E K +D+ + E + + +++ NK K RQQ+++
Sbjct: 1009 SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV 1068
Query: 807 RLEFEKQKTRL--NVQLEYSRSHLKKKLNKINTLKETIQ--KGSEDIDHLKKAEENCLQT 862
LE ++ +L V + + S+ + KE + GSE++ L+ + +
Sbjct: 1069 ELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEM 1128
Query: 863 VNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQ- 921
L + ++ K + +K+Q +E+E K+ E K K++ S TS EQ
Sbjct: 1129 HTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE 1188
Query: 922 -KRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYS 980
+RL N +DIE + + +E+E ST T K+ E+
Sbjct: 1189 LERLRSEN-------KDIENLRREREHLE-MELEKAEMERSTYVTEVRELKDLLTELQKK 1240
Query: 981 SLKEDLKALQSDQE---IEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDK 1033
+A++ ++E ++A L L ++ ++++ K A +A ++L+ ++ K
Sbjct: 1241 LDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1296
Score = 72.8 bits (177), Expect = 2e-12
Identities = 172/875 (19%), Positives = 360/875 (41%), Gaps = 122/875 (13%)
Query: 251 VKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLK 310
+K +S + + K+ K E L QLQ+ +K L +V+ + + + + +
Sbjct: 308 LKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
Query: 311 KLDVAKKSIKDS----EKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRD-- 364
+ +V +KD EK+ + ++ I E + ++ +Q+E EI H K++
Sbjct: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENG 427
Query: 365 ----------IELEASQLDRYKELKEQVRKKVATMTQQLEKLQWE--QKTDEERLAFEKR 412
+LE+ Q +L++ + V +T++ KLQ E QK + E+ A
Sbjct: 428 ILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA---- 483
Query: 413 RHGEVQGNLKQIKEQIEDHKKRIEKLEEY-TKTCMDCLKEKKQQEETLVDEIEKTKSRMS 471
Q+K Q+++ ++R E+++ Y K + ++ + V + + +S S
Sbjct: 484 ---------TQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHS 534
Query: 472 EFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGR--LFDLCHPIHKK 529
+ + L + + +L+ + E +QKR E L+ D + L H +
Sbjct: 535 KLTDTL-VSKQQLEQRLMQLMES--EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQ 591
Query: 530 YQLAVT-KVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLR-E 587
+ V + ++ +K K L ER + T + DI+ +N L+ E
Sbjct: 592 IAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASER-DRLTSKEEELKDIQNMNFLLKAE 650
Query: 588 LKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFL 647
++ + + + +L+K+ Q V +EE +S + + D L
Sbjct: 651 VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKAL 710
Query: 648 KSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQG 707
K S+++ E+ K++ ++ + IQE K+ LK ++ L++
Sbjct: 711 K--------SEVQKLQTLVSEQPNKDVVEQMEKCIQE---------KDEKLKTVEELLET 753
Query: 708 TQTRLKYSQNELEMIKKKH--LVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEF 765
++ + EL I+ ++ L Q+ Q++ ++ S L + I E+ +IK
Sbjct: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
Query: 766 QEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSR 825
+E + E ++ + +E V+++++ E K +K +EI +LE + Q+ + +++ +
Sbjct: 814 EELL---EAELLKVANKEKTVQDLKQ-EIKALK--EEIGNVQLE-KAQQLSITSKVQELQ 866
Query: 826 SHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAE 885
+ LK K ++NT+K +++ +D+ + K ++ + L A Q++ + + SSA
Sbjct: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA- 925
Query: 886 KVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSG 945
+Q EE E+V + E KRLE +L + D+
Sbjct: 926 ---SQFEE----------------LEIVLKEKENELKRLE---AMLKERESDL------- 956
Query: 946 SLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ 1005
+ TQ D+ ++ + F+ LK+ + Q H LL +
Sbjct: 957 -------------SSKTQLLQDVQDENKLFKSQIEQLKQ--QNYQQASSFPPHEELL--K 999
Query: 1006 VASQEDILLKTAAPNLRALENL-----KTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
V S+ + + L +L++ K D +++ +A EA ++ + + + K
Sbjct: 1000 VISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSK 1059
Query: 1061 RRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLS 1095
R Q E V + ++ KKL S + LS
Sbjct: 1060 ER----QQQVEAVELEAKEVLKKLFPKVSVPSNLS 1090
Score = 64.7 bits (156), Expect = 5e-10
Identities = 164/817 (20%), Positives = 322/817 (39%), Gaps = 156/817 (19%)
Query: 153 QFFEEIS--TSGELIGE-----YEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAK----L 201
QF +I+ TS ++ E EK +++++ E+ ++ + E + + L
Sbjct: 587 QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL 646
Query: 202 EKEEAERYQSLLEELKMNKIQLQLFQ--LYHNEKKIHLLNTKLEHVNRDLSVKRESLSHH 259
K E ++ Q+L E +L+ Q +Y + KI LL +L+H ++S K E
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH---EISNKMEEFKIL 703
Query: 260 ENIVKARKKEHGMLT----------------RQLQQTEKELKSVETLLNQKRPQYIKAKE 303
+ KA K E L + +Q+ +++LK+VE LL Q +E
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
Query: 304 NTSHHLKKLDVAKKSIKDSEKQCSKQEDDI------KALETELADLDAAWRSFEKQIEEE 357
+ + K ++D + +KQ D + + L+ + + D +S E+ +E E
Sbjct: 764 ELNAIRTENSSLTKEVQDLK---AKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820
Query: 358 ILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEV 417
+L + K LKE++ QLEK Q T + + E+
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNV------QLEKAQQLSITSKVQ---------EL 865
Query: 418 QGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIE-------KTKSRM 470
Q LK +EQ+ K +E+ E+ L++ +++ E+L ++ K S
Sbjct: 866 QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 471 SEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKY 530
S+F EEL ++ E +N + KR E + LK D + K
Sbjct: 926 SQF-EELEIVLKEKEN----------ELKRLEAM--LKERESD------------LSSKT 960
Query: 531 QLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG 590
QL V K+ K I LK++ + + +K I+ER +E+ G
Sbjct: 961 QLLQD----------VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISG 1010
Query: 591 CKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSG 650
+D +K +K N + E EA AL T +
Sbjct: 1011 LWNELDSLKDAVEHQRKK------NNDLREKNWEAME------------ALASTEKMLQD 1052
Query: 651 VISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQ- 709
++ S + + + E E K + + K+ L K+ + + GT
Sbjct: 1053 KVNKTSKERQQQVEAV-ELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1111
Query: 710 -TRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEK 768
+K +++L+ + H + LQ E +S + +EGI ++ +R E +E
Sbjct: 1112 SEEVKVLEHKLKEADEMHTL--------LQLECEKYKS-VLAETEGILQKLQRSVEQEEN 1162
Query: 769 IDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLE------FEKQKTRLNVQLE 822
KV+ D + I++ ++ +QE+++ R E +++ L ++LE
Sbjct: 1163 KWKVKVDESH--------KTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELE 1214
Query: 823 YSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRVTQNS 882
+ + ++ LK+ + + + +D + +E + + ++L ++ N
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTELQKKLD----------DSYSEAVRQNEELNLLKAQLNE 1264
Query: 883 SAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSL 919
+ K++T+ E +K V ++ K Q+ + IQ+ +
Sbjct: 1265 TLTKLRTEQNERQK----VAGDLHKAQQSLELIQSKI 1297
Score = 60.8 bits (146), Expect = 8e-09
Identities = 89/442 (20%), Positives = 194/442 (43%), Gaps = 68/442 (15%)
Query: 115 SVYIAELEKIGIIVKAQNCL-VFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKR 173
+V + + +++ I K Q + +G E ++ K + ++++ +G+ + + +E+
Sbjct: 847 NVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE-KDLANTGKWLQDLQEENE 905
Query: 174 KLQK-AEEDAQFNFNKKKNIAAERRQAKL---EKE-EAERYQSLLEELKMN-KIQLQLFQ 227
L+ +E AQ N K+ + A++ + ++ EKE E +R +++L+E + + + QL Q
Sbjct: 906 SLKAHVQEVAQHNL-KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ 964
Query: 228 LYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSV 287
+E K L +++E + + + S HE ++K + +++ EL S+
Sbjct: 965 DVQDENK--LFKSQIEQLKQQNYQQASSFPPHEELLKVISERE----KEISGLWNELDSL 1018
Query: 288 ETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQ-EDDIKALETELADL--- 343
+ + +R + +E ++ L +K ++D + SK+ + ++A+E E ++
Sbjct: 1019 KDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKK 1078
Query: 344 ------------DAAW-RSFEKQIEEEILHKKRDIEL--------EASQLDRYKELKEQV 382
W FEK+ +E + E+ EA ++ +L+ +
Sbjct: 1079 LFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEK 1138
Query: 383 RKKVATMTQQ-LEKLQ---------WEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHK 432
K V T+ L+KLQ W+ K DE ++ + +Q E++
Sbjct: 1139 YKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSS--EQELERLRSEN 1196
Query: 433 KRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEF--------------NEELN 478
K IE L + L++ + + T V E+ + K ++E NEELN
Sbjct: 1197 KDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELN 1256
Query: 479 LIRSELQN--AGIDTHEGKRQQ 498
L++++L + T + +RQ+
Sbjct: 1257 LLKAQLNETLTKLRTEQNERQK 1278
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 96.3 bits (238), Expect = 2e-19
Identities = 216/1025 (21%), Positives = 418/1025 (40%), Gaps = 186/1025 (18%)
Query: 145 VKKPKERTQFFEEISTS------------GELIGEYEEKKRKLQKAEEDAQFNFNKKKNI 192
+K+ ER + EEI+ EL + ++ + L K E++ NK KN+
Sbjct: 925 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 984
Query: 193 AAERRQ-----AKLEKEEA---ERYQSLLEEL-----KMN-------KIQLQLFQLYHNE 232
E AKL KE+ E +Q L++L K+N K++ Q+ L +
Sbjct: 985 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
Query: 233 KKIHLLNTKLEHVNR----DLSVKRESLSHHENIV-----KARKKEHGM----------- 272
++ L LE R DL + +ES+ EN K +KKE +
Sbjct: 1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104
Query: 273 -LTRQLQQTEKELKS----VETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCS 327
L QLQ+ KEL++ +E + +R KA++ S ++L+ + ++++ S
Sbjct: 1105 ALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164
Query: 328 KQEDDIKALETELADLDAAWRSFEKQIEEEIL-HKKRDIELEASQLDRYKELKEQVRKKV 386
Q + K E E ++ + +EE L H+ L D EL EQ+ +
Sbjct: 1165 AQIEMNKKREAE-------FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI-DNL 1216
Query: 387 ATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCM 446
+ Q+LEK + E K + + LA + +GNL+++ +ED +L E
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED------QLSE------ 1264
Query: 447 DCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEH 506
LK K+++++ L++++ + R+ + E + E + GK Q + +E
Sbjct: 1265 --LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK--QAFTQQIEE 1320
Query: 507 LKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAE 566
LKR + + + A+ A + DC L+E+ E
Sbjct: 1321 LKRQLEEEIKAK------------------------NALAHALQSSRHDC-DLLREQYEE 1355
Query: 567 PETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEAR 626
+ A + N + + + K D I+ + +L++ + + E EA
Sbjct: 1356 EQESKAELQRALSKANTEVAQWR-TKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 627 HIALSGPERQKTVALDGT--LFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQE 684
+ + E+ K + L L + + L K R +D+ + QK +E
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK-----ILAEWKQKCEE 1468
Query: 685 LKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNI 744
++ +KE + + T + + + S ++LE +K+ E LQ E+ +
Sbjct: 1469 THAELEASQKEA--RSLGTELFKIKNAYEESLDQLETLKR--------ENKNLQQEISD- 1517
Query: 745 ESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCE-----EIGVENIREFENKHVKR 799
L+E I E +RI E ++K++ + Q CE E ++ E K ++
Sbjct: 1518 ------LTEQIAEGGKRIHE----LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI 1567
Query: 800 QQEIDQKRLEFEKQKTRLNVQLEY-SRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEEN 858
Q E++Q + E +++ + +++ R+H++ + +TL I+ ++ I KK E +
Sbjct: 1568 QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627
Query: 859 CLQTVNELM-AKQQQLKDIRVTQNSSAEKVQTQI--------EEERKKFLA-VDREVGKL 908
+ +L A + + +R +N+ TQI +E+ K+ LA V+R L
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 909 QKEVVSIQTSLEQKRLEK---HNLLLDC------------------KVQDIEIILLSGSL 947
Q E+ ++ +LEQ + LLD K + +I + G +
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Query: 948 DDIIEVEMGTEAESTQATID--IYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ 1005
+DI++ E ++ +A D + +E E D S+ E +K + +E ++ L +
Sbjct: 1748 EDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK-----KNMEQTVKDLQLR 1802
Query: 1006 VASQEDILLKTAAPNLRALENL-----KTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
+ E + LK ++ LE V + + + +A + RK R ++ Q ++
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEE 1862
Query: 1061 RRYDL 1065
R ++
Sbjct: 1863 DRKNI 1867
Score = 94.7 bits (234), Expect = 5e-19
Identities = 189/936 (20%), Positives = 398/936 (42%), Gaps = 121/936 (12%)
Query: 197 RQAKLEKEEA---ERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKR 253
+ A+ EKE A E +Q + +EL ++ + + + EK + LL K + + + +
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELE----EKMVTLLKEKND-LQLQVQAEA 901
Query: 254 ESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLD 313
E L+ E K L ++++ + + E + + + K ++ S K +D
Sbjct: 902 EGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 961
Query: 314 VAKKSIKDSEKQCSKQEDDIKALETELADLD---AAWRSFEKQIEEEILHKKRDIELEAS 370
+ ++ EK+ E+ +K L E+A LD A +K ++E D++ E
Sbjct: 962 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 371 QLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFE-KRRHGEVQGNLKQIKEQIE 429
+++ + K ++ ++V + LE+ E++L + +R +++G+LK +E I
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQ--------EKKLRMDLERAKRKLEGDLKLAQESIM 1073
Query: 430 DHKKRIEKLEEYTKTC---MDCLKEKKQQEETLVDEIEKT----KSRMSEFNEELNLIRS 482
D + ++L+E K + L+ K + E+ L +++K ++R+ E EE+ R+
Sbjct: 1074 DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 483 ELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFI 542
A E +R E+ E +RL G ++KK + K+ R +
Sbjct: 1134 SRAKA-----EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKM-RRDL 1184
Query: 543 TAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG-CKMVIDVIKTQ 601
+ E A L+++ A+ L +++ + ++L + K KM ID + +
Sbjct: 1185 EEATLQHEATAAT----LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 602 FPQLKKVIQFVCGN-GLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLK 660
+ K GN +C T+E+ S E Q+ + D L + G + S +
Sbjct: 1241 VETVSKAK----GNLEKMCRTLEDQLSELKSKEEEQQRLIND--LTAQRGRLQTESGEF- 1293
Query: 661 YKARCWDEKE-----LKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYS 715
+R DEKE L + +Q+I+ELK + E ++K L Q+ S
Sbjct: 1294 --SRQLDEKEALVSQLSRGKQAFTQQIEELKRQL-----EEEIKAKNALAHALQS----S 1342
Query: 716 QNELEMIKKKHLVAFYQEQSQLQSEL---------------LNIESQCIMLSEGIKERQR 760
+++ ++++++ Y+E+ + ++EL E+ I +E ++E ++
Sbjct: 1343 RHDCDLLREQ-----YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397
Query: 761 ----RIKEFQEKIDKVEDDI---------FQHFCEEI--GVENIREFENKHVKRQQEIDQ 805
R++ +E ++ V Q+ E++ VE K+Q+ D+
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 806 KRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNE 865
E++++ + +LE S+ + ++ +K ++ + ++ LK+ +N Q +++
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 866 LMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLA--------VDREVGK---LQKEVVS 914
L +Q R+ + EK++ Q+E+E+ + A ++ E GK +Q E+
Sbjct: 1518 L-TEQIAEGGKRIHE---LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQ 1573
Query: 915 IQTSLEQKRLEKHNLLLDCKVQDIEII-LLSGSLDDIIEVEMGTEAESTQATIDIYEKEE 973
+++ +++K EK + K I I+ + +LD I + D+ E E
Sbjct: 1574 VKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI 1633
Query: 974 AFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ-VASQEDILLKTAAPNLRALENLKTVRD 1032
E L+ ++ Q I ++ L + SQED+ + A RA ++
Sbjct: 1634 QLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA----NLLQA 1689
Query: 1033 KFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQ 1068
+ +E E + + ++ QE +R L TQ
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725
Score = 94.4 bits (233), Expect = 6e-19
Identities = 197/998 (19%), Positives = 405/998 (40%), Gaps = 130/998 (13%)
Query: 74 ISSSASVKIIYVEESGEEKTFARI------IRGGCSEFRFNDNLVSRSVYIAELEKIGII 127
I A +K + EE+ A + + CSE + + + + ++ E EK
Sbjct: 919 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978
Query: 128 VKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFN 187
K +N ++ K KE+ E + + + E+K L KA+ + +
Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038
Query: 188 KKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNR 247
+ + ++ +++ E A+R L +LK+ + + + NEK + ++
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKR--KLEGDLKLAQESIMDIE---NEK---------QQLDE 1084
Query: 248 DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSH 307
L K +S+ ++ ++ + L +++++ + ++ +E + +R KA++ S
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEIL-HKKRDIE 366
++L+ + ++++ S Q + K E E ++ + +EE L H+
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAE-------FQKMRRDLEEATLQHEATAAT 1197
Query: 367 LEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
L D EL EQ+ + + Q+LEK + E K + + LA + +GNL+++
Sbjct: 1198 LRKKHADSVAELGEQI-DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 427 QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQN 486
+ED +L E LK K+++++ L++++ + R+ + E + E +
Sbjct: 1257 TLED------QLSE--------LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 487 AGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIV 546
GK Q + +E LKR + + + A+
Sbjct: 1303 LVSQLSRGK--QAFTQQIEELKRQLEEEIKAK------------------------NALA 1336
Query: 547 VASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLK 606
A + DC L+E+ E + A + N + + + K D I+ + +L+
Sbjct: 1337 HALQSSRHDC-DLLREQYEEEQESKAELQRALSKANTEVAQWR-TKYETDAIQ-RTEELE 1393
Query: 607 KVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGT--LFLKSGVISGGSSDLKYKAR 664
+ + + E EA + + E+ K + L L + + L K R
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 665 CWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKK 724
+D+ + QK +E ++ +KE + + T + + + S ++LE +K+
Sbjct: 1454 NFDK-----ILAEWKQKCEETHAELEASQKEA--RSLGTELFKIKNAYEESLDQLETLKR 1506
Query: 725 KHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCE-- 782
E LQ E+ + L+E I E +RI E ++K++ + Q CE
Sbjct: 1507 --------ENKNLQQEISD-------LTEQIAEGGKRIHE----LEKIKKQVEQEKCELQ 1547
Query: 783 ---EIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQL-EYSRSHLKKKLNKINTL 838
E ++ E K ++ Q E++Q + E +++ + ++ + R+H++ + +TL
Sbjct: 1548 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607
Query: 839 KETIQKGSEDIDHLKKAEENCLQTVNEL-MAKQQQLKDIRVTQNSSAEKVQTQI------ 891
I+ ++ I KK E + + +L A + + +R +N+ TQI
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDAL 1667
Query: 892 --EEERKKFLA-VDREVGKLQKEVVSIQTSLEQ---KRLEKHNLLLDCK-------VQDI 938
+E+ K+ LA V+R LQ E+ ++ +LEQ R LLD Q+
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 939 EIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAH 998
+I L+ I G + Q + EK + D + + E+LK +Q+ AH
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK---KEQDTSAH 1784
Query: 999 L-RLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQ 1035
L R+ + +D+ L+ AL+ K K +
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE 1822
Score = 92.0 bits (227), Expect = 3e-18
Identities = 176/920 (19%), Positives = 370/920 (40%), Gaps = 161/920 (17%)
Query: 144 SVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEK 203
S + KE EE + + + E K+++L E+ K+KN + Q + E
Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEAKRKEL----EEKMVTLLKEKNDL--QLQVQAEA 901
Query: 204 EEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIV 263
E + ++L KIQL+ K++ E +N +L+ K+ L E+
Sbjct: 902 EGLADAEERCDQLIKTKIQLEA-----KIKEVTERAEDEEEINAELTAKKRKL---EDEC 953
Query: 264 KARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSE 323
KK+ L L + EKE + E + + E + KL KK+++++
Sbjct: 954 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDET----IAKLTKEKKALQEAH 1009
Query: 324 KQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVR 383
+Q DD++A E ++ L A E+Q+++ LE S EQ +
Sbjct: 1010 QQTL---DDLQAEEDKVNTLTKAKIKLEQQVDD----------LEGSL--------EQEK 1048
Query: 384 KKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTK 443
K + + KL+ + K +E + + ++ LK+ + +I + + +IE +
Sbjct: 1049 KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108
Query: 444 TCMDCLKEKKQQEETLVDEIE-------KTKSRMSEFNEELNLIRSELQNAGIDTH-EGK 495
+KE + + E L +EIE K + + S+ + EL I L+ AG T + +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 496 RQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKD 555
+KR + ++R ++ +++ + + ++ E++ D
Sbjct: 1169 MNKKREAEFQKMRRDLEEATL------------QHEATAATLRKKHADSVAELGEQI--D 1214
Query: 556 CIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGN 615
++ +K++ + ++ + ++ D+ E + + KG L+K
Sbjct: 1215 NLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG-------------NLEK-------- 1253
Query: 616 GLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKE----- 670
+C T+E+ S E Q+ + D L + G + S + +R DEKE
Sbjct: 1254 --MCRTLEDQLSELKSKEEEQQRLIND--LTAQRGRLQTESGEF---SRQLDEKEALVSQ 1306
Query: 671 LKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAF 730
L + +Q+I+ELK +Q++ E IK K+ +A
Sbjct: 1307 LSRGKQAFTQQIEELK------------RQLE-----------------EEIKAKNALAH 1337
Query: 731 YQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIR 790
+ S+ C +L E +E Q E Q + K ++ Q
Sbjct: 1338 ALQSSR---------HDCDLLREQYEEEQESKAELQRALSKANTEVAQW----------- 1377
Query: 791 EFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDID 850
K + + Q+ E E+ K +L +L+ + H++ K +L++T Q+ +++
Sbjct: 1378 -----RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432
Query: 851 HLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQK 910
L E L KQ+ I E+ ++E +K+ ++ E+ K++
Sbjct: 1433 DLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKN 1492
Query: 911 EVVSIQTSLEQ-KRLEKHNLLLDCKVQDIEIILLSGS--LDDIIEVEMGTEAESTQATID 967
+ + SL+Q + L++ N L ++ D+ + G + ++ +++ E E +
Sbjct: 1493 ---AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA 1549
Query: 968 IYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENL 1027
+ E E + E E+ K L+ E+ + +++A +++ + + ++R +E++
Sbjct: 1550 LEEAEASLE------HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603
Query: 1028 KTVRD-KFQESTDAFEASRK 1046
++ D + + DA +K
Sbjct: 1604 QSTLDAEIRSRNDAIRLKKK 1623
Score = 79.0 bits (193), Expect = 3e-14
Identities = 183/942 (19%), Positives = 365/942 (38%), Gaps = 186/942 (19%)
Query: 122 EKIGIIVKAQNCL--VFQGTVESISVKKPKERTQFFEEISTS---GELIGEYEEKK---- 172
E I + K + L Q T++ + ++ K T +I +L G E++K
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052
Query: 173 ---RKLQKAEEDAQFNFNKKKNIAAERRQA--KLEKEEAE--RYQSLLEELKMNKIQLQL 225
R +K E D + +I E++Q KL+K+E E QS +E+ + IQLQ
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ- 1111
Query: 226 FQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELK 285
KKI L ++E + ++ +R S + E K+ L+R+L++ + L+
Sbjct: 1112 -------KKIKELQARIEELEEEIEAERASRAKAE-------KQRSDLSRELEEISERLE 1157
Query: 286 ------SVETLLNQKRPQYIKA-----KENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIK 334
S + +N+KR + +E T H +K DS + +Q D+++
Sbjct: 1158 EAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1217
Query: 335 A----LETELADLDAAWRSFEKQIEEEILHKKRDIELEA----SQLDRYKELKEQVRKKV 386
LE E +++ +E + K ++E QL K +E+ ++ +
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVET-VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 387 ATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK--------- 437
+T Q +LQ E +L ++ ++ + +QIE+ K+++E+
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 438 --LEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGK 495
L+ C D L+E+ ++E+ E+++ +S+ N E+ R++ + I E
Sbjct: 1337 HALQSSRHDC-DLLREQYEEEQESKAELQRA---LSKANTEVAQWRTKYETDAIQRTEEL 1392
Query: 496 RQQKR-------------------AEVLEHLKRLYPDSVFGRLFDL------CHPIHKKY 530
+ K+ LE K+ + V + D+ C + KK
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452
Query: 531 Q-----LAVTKVFGRFITAIVVASEKVAKDC-IRFLKEERAEPETFLALDYL-------- 576
+ LA K A + AS+K A+ K + A E+ L+ L
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512
Query: 577 -DIKPINERLRELKGCKMV--IDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGP 633
+I + E++ E G K + ++ IK Q Q K +Q EE + + +
Sbjct: 1513 QEISDLTEQIAE--GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 634 ERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT-L 692
Q +D + K ++E+ L+ + ++ ++ + +
Sbjct: 1571 LNQVKSEVDRKIAEK-------------------DEEIDQLKRNHIRIVESMQSTLDAEI 1611
Query: 693 RKETDLKQIQTLIQGTQTRLKYSQNELEMIKKK-----------------HLVAFYQEQS 735
R D +++ ++G ++ N + + HL + Q
Sbjct: 1612 RSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQE 1671
Query: 736 QLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENK 795
L+ +L +E + +L I+E + +++ E+ K+ + E + + + +
Sbjct: 1672 DLKEQLAMVERRANLLQAEIEELRATLEQ-TERSRKIAEQELLDASERVQLLHTQNTSLI 1730
Query: 796 HVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKA 855
+ K++ E D +++ E + + + + KK + + E ++K + HL++
Sbjct: 1731 NTKKKLETDISQMQGEMED--ILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1788
Query: 856 EENCLQTVNELM-----AKQQQLK------------------DIRVTQNSSAEKVQT--- 889
++N QTV +L A+Q LK ++ Q +AE V+
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848
Query: 890 ----------QIEEERKKFLAVDREVGKLQKEVVSIQTSLEQ 921
Q EE+RK L + V KLQ +V S + E+
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890
Score = 70.1 bits (170), Expect = 1e-11
Identities = 172/909 (18%), Positives = 374/909 (41%), Gaps = 104/909 (11%)
Query: 52 KIANLRVKNIQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNL 111
+I+NL+ K E G + K I + +EE EE R R +
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQA----RIEELEEEIEAERASRAKAEK------- 1140
Query: 112 VSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTS-GELIGEYEE 170
RS ELE+I L G S ++ K+R F+++ E ++E
Sbjct: 1141 -QRSDLSRELEEIS------ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1193
Query: 171 KKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMN-----KIQLQL 225
L+K D+ ++ + +R + KLEKE++E + ++L N K + L
Sbjct: 1194 TAATLRKKHADSVAELGEQID-NLQRVKQKLEKEKSEMKMEI-DDLASNVETVSKAKGNL 1251
Query: 226 FQLYHN-EKKIHLLNTKLEHVNR---DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTE 281
++ E ++ L +K E R DL+ +R L + E L QL + +
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 282 KELKSVETLLNQKRPQYIKAKENTSHHLKK----LDVAKKSIKDSEKQCSKQEDDIKALE 337
+ L ++ + IKAK +H L+ D+ ++ ++ ++ ++ + +
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 338 TELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQ 397
TE+A + + Q EE+ K+ + A +L +E E V K A++ + ++LQ
Sbjct: 1372 TEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428
Query: 398 WE--------QKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCL 449
E ++T+ A +K++ L + K++ E+ +E ++ ++ L
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRN-FDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487
Query: 450 KEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKR 509
+ K E +D++E K +E++ + ++ G HE ++ +K+ +E K
Sbjct: 1488 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ---VEQEKC 1544
Query: 510 LYPDSVFGRLFDLCHPIHK--KYQLAVTKVFGRFITAIVVASEKV---AKDCIRFLKEER 564
++ L H K + QL + +V I E++ ++ IR ++ +
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 565 AEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGN-----GLVC 619
+ + +I+ N+ +R K + ++ ++ Q ++ N G++
Sbjct: 1605 STLDA-------EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 620 ETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKY------KARCWDEKELKN 673
+T S + ++ +A+ + ++ ++ +L+ ++R E+EL +
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAM---VERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1714
Query: 674 LRDRRSQKIQELKGLMKTLRK-ETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQ 732
+R + L+ T +K ETD+ Q+Q ++ L+ ++N E KK
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI---LQEARNAEEKAKKA-----IT 1766
Query: 733 EQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGV--ENIR 790
+ + + EL + L K ++ +K+ Q ++D+ E + ++I +R
Sbjct: 1767 DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826
Query: 791 EFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDID 850
E E + V+ +Q+ + + ++ ++ R +L Y +K + ++ L + +Q +
Sbjct: 1827 ELEGE-VESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA---KVK 1882
Query: 851 HLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQK 910
K+ E + N +AK + K+Q ++EE ++ + +V KL+
Sbjct: 1883 SYKRQAEEAEEQSNTNLAKFR--------------KLQHELEEAEERADIAESQVNKLRV 1928
Query: 911 EVVSIQTSL 919
+ + T +
Sbjct: 1929 KSREVHTKV 1937
Score = 64.3 bits (155), Expect = 7e-10
Identities = 78/381 (20%), Positives = 175/381 (45%), Gaps = 37/381 (9%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSE--- 740
++K L+K+ E ++ ++ Q + L S+ + + +++K +V +E++ LQ +
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEK-MVTLLKEKNDLQLQVQA 899
Query: 741 ----LLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVE---NIREFE 793
L + E +C L + + + +IKE E+ ED+ EEI E R+ E
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTER---AEDE------EEINAELTAKKRKLE 950
Query: 794 NKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLK 853
++ + +++ID L K + + + + +K ++ L ETI K +++ L+
Sbjct: 951 DECSELKKDIDDLELTLAKVEKEKHA----TENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 854 KAEENCLQTVNELMAKQQQLKDI---RVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQK 910
+A + QT+++L A++ ++ + ++ + ++ +E+E+K + ++R KL+
Sbjct: 1007 EAHQ---QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG 1063
Query: 911 EVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDD--IIEVEMGTEAESTQATIDI 968
++ Q S+ EK L K ++ EI L ++D + +++ + + QA I+
Sbjct: 1064 DLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE- 1122
Query: 969 YEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLK 1028
E EE E + +S KA + ++ L + +++ N + +
Sbjct: 1123 -ELEEEIEAERAS---RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178
Query: 1029 TVRDKFQESTDAFEASRKEAR 1049
+R +E+T EA+ R
Sbjct: 1179 KMRRDLEEATLQHEATAATLR 1199
Score = 48.1 bits (113), Expect = 5e-05
Identities = 72/333 (21%), Positives = 141/333 (42%), Gaps = 44/333 (13%)
Query: 141 ESISVKKPKER--TQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNK--------KK 190
++I +KK E + +++ + + E R Q +D Q + + K+
Sbjct: 1616 DAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE 1675
Query: 191 NIAAERRQAKLEKEEAERYQSLLEELKMNK--IQLQLFQLYHNEKKIHLLNTKLEHVNRD 248
+A R+A L + E E ++ LE+ + ++ + +L + +H NT L + +
Sbjct: 1676 QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1735
Query: 249 LSVKRESLSHH-ENIVK----ARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKE 303
L + E+I++ A +K +T E+ K +T + +R + K E
Sbjct: 1736 LETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK--KNME 1793
Query: 304 NTSHHLK-KLDVAKK-SIKDSEKQCSKQEDDIKALETEL-------ADLDAAWRSFEKQI 354
T L+ +LD A++ ++K +KQ K E ++ LE E+ A+ R E+++
Sbjct: 1794 QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRV 1853
Query: 355 EEEILHKKRD----------IELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDE 404
+E + D ++ +++ YK E+ ++ T + KLQ E + E
Sbjct: 1854 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAE 1913
Query: 405 ERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK 437
ER E Q N ++K + E H K I +
Sbjct: 1914 ERADI-----AESQVNKLRVKSR-EVHTKVISE 1940
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 96.3 bits (238), Expect = 2e-19
Identities = 216/1025 (21%), Positives = 418/1025 (40%), Gaps = 186/1025 (18%)
Query: 145 VKKPKERTQFFEEISTS------------GELIGEYEEKKRKLQKAEEDAQFNFNKKKNI 192
+K+ ER + EEI+ EL + ++ + L K E++ NK KN+
Sbjct: 925 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNL 984
Query: 193 AAERRQ-----AKLEKEEA---ERYQSLLEEL-----KMN-------KIQLQLFQLYHNE 232
E AKL KE+ E +Q L++L K+N K++ Q+ L +
Sbjct: 985 TEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
Query: 233 KKIHLLNTKLEHVNR----DLSVKRESLSHHENIV-----KARKKEHGM----------- 272
++ L LE R DL + +ES+ EN K +KKE +
Sbjct: 1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104
Query: 273 -LTRQLQQTEKELKS----VETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCS 327
L QLQ+ KEL++ +E + +R KA++ S ++L+ + ++++ S
Sbjct: 1105 ALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164
Query: 328 KQEDDIKALETELADLDAAWRSFEKQIEEEIL-HKKRDIELEASQLDRYKELKEQVRKKV 386
Q + K E E ++ + +EE L H+ L D EL EQ+ +
Sbjct: 1165 AQIEMNKKREAE-------FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI-DNL 1216
Query: 387 ATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCM 446
+ Q+LEK + E K + + LA + +GNL+++ +ED +L E
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLED------QLSE------ 1264
Query: 447 DCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEH 506
LK K+++++ L++++ + R+ + E + E + GK Q + +E
Sbjct: 1265 --LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK--QAFTQQIEE 1320
Query: 507 LKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAE 566
LKR + + + A+ A + DC L+E+ E
Sbjct: 1321 LKRQLEEEIKAK------------------------NALAHALQSSRHDC-DLLREQYEE 1355
Query: 567 PETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEAR 626
+ A + N + + + K D I+ + +L++ + + E EA
Sbjct: 1356 EQESKAELQRALSKANTEVAQWR-TKYETDAIQ-RTEELEEAKKKLAQRLQAAEEHVEAV 1413
Query: 627 HIALSGPERQKTVALDGT--LFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQE 684
+ + E+ K + L L + + L K R +D+ + QK +E
Sbjct: 1414 NAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK-----ILAEWKQKCEE 1468
Query: 685 LKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNI 744
++ +KE + + T + + + S ++LE +K+ E LQ E+ +
Sbjct: 1469 THAELEASQKEA--RSLGTELFKIKNAYEESLDQLETLKR--------ENKNLQQEISD- 1517
Query: 745 ESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCE-----EIGVENIREFENKHVKR 799
L+E I E +RI E ++K++ + Q CE E ++ E K ++
Sbjct: 1518 ------LTEQIAEGGKRIHE----LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI 1567
Query: 800 QQEIDQKRLEFEKQKTRLNVQLEY-SRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEEN 858
Q E++Q + E +++ + +++ R+H++ + +TL I+ ++ I KK E +
Sbjct: 1568 QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627
Query: 859 CLQTVNELM-AKQQQLKDIRVTQNSSAEKVQTQI--------EEERKKFLA-VDREVGKL 908
+ +L A + + +R +N+ TQI +E+ K+ LA V+R L
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 909 QKEVVSIQTSLEQKRLEK---HNLLLDC------------------KVQDIEIILLSGSL 947
Q E+ ++ +LEQ + LLD K + +I + G +
Sbjct: 1688 QAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEM 1747
Query: 948 DDIIEVEMGTEAESTQATID--IYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ 1005
+DI++ E ++ +A D + +E E D S+ E +K + +E ++ L +
Sbjct: 1748 EDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK-----KNMEQTVKDLQLR 1802
Query: 1006 VASQEDILLKTAAPNLRALENL-----KTVRDKFQESTDAFEASRKEARLCRQEFEQVKK 1060
+ E + LK ++ LE V + + + +A + RK R ++ Q ++
Sbjct: 1803 LDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEE 1862
Query: 1061 RRYDL 1065
R ++
Sbjct: 1863 DRKNI 1867
Score = 94.7 bits (234), Expect = 5e-19
Identities = 189/936 (20%), Positives = 398/936 (42%), Gaps = 121/936 (12%)
Query: 197 RQAKLEKEEA---ERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKR 253
+ A+ EKE A E +Q + +EL ++ + + + EK + LL K + + + +
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELE----EKMVTLLKEKND-LQLQVQAEA 901
Query: 254 ESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLD 313
E L+ E K L ++++ + + E + + + K ++ S K +D
Sbjct: 902 EGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 961
Query: 314 VAKKSIKDSEKQCSKQEDDIKALETELADLD---AAWRSFEKQIEEEILHKKRDIELEAS 370
+ ++ EK+ E+ +K L E+A LD A +K ++E D++ E
Sbjct: 962 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED 1021
Query: 371 QLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFE-KRRHGEVQGNLKQIKEQIE 429
+++ + K ++ ++V + LE+ E++L + +R +++G+LK +E I
Sbjct: 1022 KVNTLTKAKIKLEQQVDDLEGSLEQ--------EKKLRMDLERAKRKLEGDLKLAQESIM 1073
Query: 430 DHKKRIEKLEEYTKTC---MDCLKEKKQQEETLVDEIEKT----KSRMSEFNEELNLIRS 482
D + ++L+E K + L+ K + E+ L +++K ++R+ E EE+ R+
Sbjct: 1074 DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 483 ELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFI 542
A E +R E+ E +RL G ++KK + K+ R +
Sbjct: 1134 SRAKA-----EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQKM-RRDL 1184
Query: 543 TAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG-CKMVIDVIKTQ 601
+ E A L+++ A+ L +++ + ++L + K KM ID + +
Sbjct: 1185 EEATLQHEATAAT----LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN 1240
Query: 602 FPQLKKVIQFVCGN-GLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLK 660
+ K GN +C T+E+ S E Q+ + D L + G + S +
Sbjct: 1241 VETVSKAK----GNLEKMCRTLEDQLSELKSKEEEQQRLIND--LTAQRGRLQTESGEF- 1293
Query: 661 YKARCWDEKE-----LKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYS 715
+R DEKE L + +Q+I+ELK + E ++K L Q+ S
Sbjct: 1294 --SRQLDEKEALVSQLSRGKQAFTQQIEELKRQL-----EEEIKAKNALAHALQS----S 1342
Query: 716 QNELEMIKKKHLVAFYQEQSQLQSEL---------------LNIESQCIMLSEGIKERQR 760
+++ ++++++ Y+E+ + ++EL E+ I +E ++E ++
Sbjct: 1343 RHDCDLLREQ-----YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397
Query: 761 ----RIKEFQEKIDKVEDDI---------FQHFCEEI--GVENIREFENKHVKRQQEIDQ 805
R++ +E ++ V Q+ E++ VE K+Q+ D+
Sbjct: 1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDK 1457
Query: 806 KRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNE 865
E++++ + +LE S+ + ++ +K ++ + ++ LK+ +N Q +++
Sbjct: 1458 ILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISD 1517
Query: 866 LMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLA--------VDREVGK---LQKEVVS 914
L +Q R+ + EK++ Q+E+E+ + A ++ E GK +Q E+
Sbjct: 1518 L-TEQIAEGGKRIHE---LEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQ 1573
Query: 915 IQTSLEQKRLEKHNLLLDCKVQDIEII-LLSGSLDDIIEVEMGTEAESTQATIDIYEKEE 973
+++ +++K EK + K I I+ + +LD I + D+ E E
Sbjct: 1574 VKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI 1633
Query: 974 AFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ-VASQEDILLKTAAPNLRALENLKTVRD 1032
E L+ ++ Q I ++ L + SQED+ + A RA ++
Sbjct: 1634 QLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRA----NLLQA 1689
Query: 1033 KFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQ 1068
+ +E E + + ++ QE +R L TQ
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1725
Score = 94.4 bits (233), Expect = 6e-19
Identities = 197/998 (19%), Positives = 405/998 (40%), Gaps = 130/998 (13%)
Query: 74 ISSSASVKIIYVEESGEEKTFARI------IRGGCSEFRFNDNLVSRSVYIAELEKIGII 127
I A +K + EE+ A + + CSE + + + + ++ E EK
Sbjct: 919 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 978
Query: 128 VKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFN 187
K +N ++ K KE+ E + + + E+K L KA+ + +
Sbjct: 979 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVD 1038
Query: 188 KKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNR 247
+ + ++ +++ E A+R L +LK+ + + + NEK + ++
Sbjct: 1039 DLEGSLEQEKKLRMDLERAKR--KLEGDLKLAQESIMDIE---NEK---------QQLDE 1084
Query: 248 DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSH 307
L K +S+ ++ ++ + L +++++ + ++ +E + +R KA++ S
Sbjct: 1085 KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1144
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEIL-HKKRDIE 366
++L+ + ++++ S Q + K E E ++ + +EE L H+
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAE-------FQKMRRDLEEATLQHEATAAT 1197
Query: 367 LEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
L D EL EQ+ + + Q+LEK + E K + + LA + +GNL+++
Sbjct: 1198 LRKKHADSVAELGEQI-DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR 1256
Query: 427 QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQN 486
+ED +L E LK K+++++ L++++ + R+ + E + E +
Sbjct: 1257 TLED------QLSE--------LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 487 AGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIV 546
GK Q + +E LKR + + + A+
Sbjct: 1303 LVSQLSRGK--QAFTQQIEELKRQLEEEIKAK------------------------NALA 1336
Query: 547 VASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLK 606
A + DC L+E+ E + A + N + + + K D I+ + +L+
Sbjct: 1337 HALQSSRHDC-DLLREQYEEEQESKAELQRALSKANTEVAQWR-TKYETDAIQ-RTEELE 1393
Query: 607 KVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGT--LFLKSGVISGGSSDLKYKAR 664
+ + + E EA + + E+ K + L L + + L K R
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 665 CWDEKELKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKK 724
+D+ + QK +E ++ +KE + + T + + + S ++LE +K+
Sbjct: 1454 NFDK-----ILAEWKQKCEETHAELEASQKEA--RSLGTELFKIKNAYEESLDQLETLKR 1506
Query: 725 KHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCE-- 782
E LQ E+ + L+E I E +RI E ++K++ + Q CE
Sbjct: 1507 --------ENKNLQQEISD-------LTEQIAEGGKRIHE----LEKIKKQVEQEKCELQ 1547
Query: 783 ---EIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQL-EYSRSHLKKKLNKINTL 838
E ++ E K ++ Q E++Q + E +++ + ++ + R+H++ + +TL
Sbjct: 1548 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTL 1607
Query: 839 KETIQKGSEDIDHLKKAEENCLQTVNEL-MAKQQQLKDIRVTQNSSAEKVQTQI------ 891
I+ ++ I KK E + + +L A + + +R +N+ TQI
Sbjct: 1608 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDAL 1667
Query: 892 --EEERKKFLA-VDREVGKLQKEVVSIQTSLEQ---KRLEKHNLLLDCK-------VQDI 938
+E+ K+ LA V+R LQ E+ ++ +LEQ R LLD Q+
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 939 EIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKALQSDQEIEAH 998
+I L+ I G + Q + EK + D + + E+LK +Q+ AH
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK---KEQDTSAH 1784
Query: 999 L-RLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQ 1035
L R+ + +D+ L+ AL+ K K +
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLE 1822
Score = 92.0 bits (227), Expect = 3e-18
Identities = 176/920 (19%), Positives = 370/920 (40%), Gaps = 161/920 (17%)
Query: 144 SVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEK 203
S + KE EE + + + E K+++L E+ K+KN + Q + E
Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEAKRKEL----EEKMVTLLKEKNDL--QLQVQAEA 901
Query: 204 EEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIV 263
E + ++L KIQL+ K++ E +N +L+ K+ L E+
Sbjct: 902 EGLADAEERCDQLIKTKIQLEA-----KIKEVTERAEDEEEINAELTAKKRKL---EDEC 953
Query: 264 KARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSE 323
KK+ L L + EKE + E + + E + KL KK+++++
Sbjct: 954 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDET----IAKLTKEKKALQEAH 1009
Query: 324 KQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVR 383
+Q DD++A E ++ L A E+Q+++ LE S EQ +
Sbjct: 1010 QQTL---DDLQAEEDKVNTLTKAKIKLEQQVDD----------LEGSL--------EQEK 1048
Query: 384 KKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTK 443
K + + KL+ + K +E + + ++ LK+ + +I + + +IE +
Sbjct: 1049 KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGI 1108
Query: 444 TCMDCLKEKKQQEETLVDEIE-------KTKSRMSEFNEELNLIRSELQNAGIDTH-EGK 495
+KE + + E L +EIE K + + S+ + EL I L+ AG T + +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1168
Query: 496 RQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKD 555
+KR + ++R ++ +++ + + ++ E++ D
Sbjct: 1169 MNKKREAEFQKMRRDLEEATL------------QHEATAATLRKKHADSVAELGEQI--D 1214
Query: 556 CIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGN 615
++ +K++ + ++ + ++ D+ E + + KG L+K
Sbjct: 1215 NLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG-------------NLEK-------- 1253
Query: 616 GLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKE----- 670
+C T+E+ S E Q+ + D L + G + S + +R DEKE
Sbjct: 1254 --MCRTLEDQLSELKSKEEEQQRLIND--LTAQRGRLQTESGEF---SRQLDEKEALVSQ 1306
Query: 671 LKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAF 730
L + +Q+I+ELK +Q++ E IK K+ +A
Sbjct: 1307 LSRGKQAFTQQIEELK------------RQLE-----------------EEIKAKNALAH 1337
Query: 731 YQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIR 790
+ S+ C +L E +E Q E Q + K ++ Q
Sbjct: 1338 ALQSSR---------HDCDLLREQYEEEQESKAELQRALSKANTEVAQW----------- 1377
Query: 791 EFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDID 850
K + + Q+ E E+ K +L +L+ + H++ K +L++T Q+ +++
Sbjct: 1378 -----RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVE 1432
Query: 851 HLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQK 910
L E L KQ+ I E+ ++E +K+ ++ E+ K++
Sbjct: 1433 DLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKN 1492
Query: 911 EVVSIQTSLEQ-KRLEKHNLLLDCKVQDIEIILLSGS--LDDIIEVEMGTEAESTQATID 967
+ + SL+Q + L++ N L ++ D+ + G + ++ +++ E E +
Sbjct: 1493 ---AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA 1549
Query: 968 IYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENL 1027
+ E E + E E+ K L+ E+ + +++A +++ + + ++R +E++
Sbjct: 1550 LEEAEASLE------HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESM 1603
Query: 1028 KTVRD-KFQESTDAFEASRK 1046
++ D + + DA +K
Sbjct: 1604 QSTLDAEIRSRNDAIRLKKK 1623
Score = 79.0 bits (193), Expect = 3e-14
Identities = 183/942 (19%), Positives = 365/942 (38%), Gaps = 186/942 (19%)
Query: 122 EKIGIIVKAQNCL--VFQGTVESISVKKPKERTQFFEEISTS---GELIGEYEEKK---- 172
E I + K + L Q T++ + ++ K T +I +L G E++K
Sbjct: 993 ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRM 1052
Query: 173 ---RKLQKAEEDAQFNFNKKKNIAAERRQA--KLEKEEAE--RYQSLLEELKMNKIQLQL 225
R +K E D + +I E++Q KL+K+E E QS +E+ + IQLQ
Sbjct: 1053 DLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQ- 1111
Query: 226 FQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELK 285
KKI L ++E + ++ +R S + E K+ L+R+L++ + L+
Sbjct: 1112 -------KKIKELQARIEELEEEIEAERASRAKAE-------KQRSDLSRELEEISERLE 1157
Query: 286 ------SVETLLNQKRPQYIKA-----KENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIK 334
S + +N+KR + +E T H +K DS + +Q D+++
Sbjct: 1158 EAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1217
Query: 335 A----LETELADLDAAWRSFEKQIEEEILHKKRDIELEA----SQLDRYKELKEQVRKKV 386
LE E +++ +E + K ++E QL K +E+ ++ +
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVET-VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 387 ATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK--------- 437
+T Q +LQ E +L ++ ++ + +QIE+ K+++E+
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 438 --LEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGK 495
L+ C D L+E+ ++E+ E+++ +S+ N E+ R++ + I E
Sbjct: 1337 HALQSSRHDC-DLLREQYEEEQESKAELQRA---LSKANTEVAQWRTKYETDAIQRTEEL 1392
Query: 496 RQQKR-------------------AEVLEHLKRLYPDSVFGRLFDL------CHPIHKKY 530
+ K+ LE K+ + V + D+ C + KK
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452
Query: 531 Q-----LAVTKVFGRFITAIVVASEKVAKDC-IRFLKEERAEPETFLALDYL-------- 576
+ LA K A + AS+K A+ K + A E+ L+ L
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQ 1512
Query: 577 -DIKPINERLRELKGCKMV--IDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGP 633
+I + E++ E G K + ++ IK Q Q K +Q EE + + +
Sbjct: 1513 QEISDLTEQIAE--GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 634 ERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT-L 692
Q +D + K ++E+ L+ + ++ ++ + +
Sbjct: 1571 LNQVKSEVDRKIAEK-------------------DEEIDQLKRNHIRIVESMQSTLDAEI 1611
Query: 693 RKETDLKQIQTLIQGTQTRLKYSQNELEMIKKK-----------------HLVAFYQEQS 735
R D +++ ++G ++ N + + HL + Q
Sbjct: 1612 RSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQE 1671
Query: 736 QLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENK 795
L+ +L +E + +L I+E + +++ E+ K+ + E + + + +
Sbjct: 1672 DLKEQLAMVERRANLLQAEIEELRATLEQ-TERSRKIAEQELLDASERVQLLHTQNTSLI 1730
Query: 796 HVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKA 855
+ K++ E D +++ E + + + + KK + + E ++K + HL++
Sbjct: 1731 NTKKKLETDISQMQGEMED--ILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1788
Query: 856 EENCLQTVNELM-----AKQQQLK------------------DIRVTQNSSAEKVQT--- 889
++N QTV +L A+Q LK ++ Q +AE V+
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848
Query: 890 ----------QIEEERKKFLAVDREVGKLQKEVVSIQTSLEQ 921
Q EE+RK L + V KLQ +V S + E+
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEE 1890
Score = 70.1 bits (170), Expect = 1e-11
Identities = 172/909 (18%), Positives = 374/909 (41%), Gaps = 104/909 (11%)
Query: 52 KIANLRVKNIQELIHGAHIGKPISSSASVKIIYVEESGEEKTFARIIRGGCSEFRFNDNL 111
+I+NL+ K E G + K I + +EE EE R R +
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQA----RIEELEEEIEAERASRAKAEK------- 1140
Query: 112 VSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTS-GELIGEYEE 170
RS ELE+I L G S ++ K+R F+++ E ++E
Sbjct: 1141 -QRSDLSRELEEIS------ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1193
Query: 171 KKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMN-----KIQLQL 225
L+K D+ ++ + +R + KLEKE++E + ++L N K + L
Sbjct: 1194 TAATLRKKHADSVAELGEQID-NLQRVKQKLEKEKSEMKMEI-DDLASNVETVSKAKGNL 1251
Query: 226 FQLYHN-EKKIHLLNTKLEHVNR---DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTE 281
++ E ++ L +K E R DL+ +R L + E L QL + +
Sbjct: 1252 EKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 282 KELKSVETLLNQKRPQYIKAKENTSHHLKK----LDVAKKSIKDSEKQCSKQEDDIKALE 337
+ L ++ + IKAK +H L+ D+ ++ ++ ++ ++ + +
Sbjct: 1312 QAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKAN 1371
Query: 338 TELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQ 397
TE+A + + Q EE+ K+ + A +L +E E V K A++ + ++LQ
Sbjct: 1372 TEVAQWRTKYETDAIQRTEELEEAKKKL---AQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428
Query: 398 WE--------QKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCL 449
E ++T+ A +K++ L + K++ E+ +E ++ ++ L
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRN-FDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487
Query: 450 KEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKR 509
+ K E +D++E K +E++ + ++ G HE ++ +K+ +E K
Sbjct: 1488 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQ---VEQEKC 1544
Query: 510 LYPDSVFGRLFDLCHPIHK--KYQLAVTKVFGRFITAIVVASEKV---AKDCIRFLKEER 564
++ L H K + QL + +V I E++ ++ IR ++ +
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 565 AEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGN-----GLVC 619
+ + +I+ N+ +R K + ++ ++ Q ++ N G++
Sbjct: 1605 STLDA-------EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 620 ETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKY------KARCWDEKELKN 673
+T S + ++ +A+ + ++ ++ +L+ ++R E+EL +
Sbjct: 1658 DTQIHLDDALRSQEDLKEQLAM---VERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1714
Query: 674 LRDRRSQKIQELKGLMKTLRK-ETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQ 732
+R + L+ T +K ETD+ Q+Q ++ L+ ++N E KK
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI---LQEARNAEEKAKKA-----IT 1766
Query: 733 EQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGV--ENIR 790
+ + + EL + L K ++ +K+ Q ++D+ E + ++I +R
Sbjct: 1767 DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826
Query: 791 EFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDID 850
E E + V+ +Q+ + + ++ ++ R +L Y +K + ++ L + +Q +
Sbjct: 1827 ELEGE-VESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQA---KVK 1882
Query: 851 HLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQK 910
K+ E + N +AK + K+Q ++EE ++ + +V KL+
Sbjct: 1883 SYKRQAEEAEEQSNTNLAKFR--------------KLQHELEEAEERADIAESQVNKLRV 1928
Query: 911 EVVSIQTSL 919
+ + T +
Sbjct: 1929 KSREVHTKV 1937
Score = 64.3 bits (155), Expect = 7e-10
Identities = 78/381 (20%), Positives = 175/381 (45%), Gaps = 37/381 (9%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSE--- 740
++K L+K+ E ++ ++ Q + L S+ + + +++K +V +E++ LQ +
Sbjct: 841 KIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEK-MVTLLKEKNDLQLQVQA 899
Query: 741 ----LLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVE---NIREFE 793
L + E +C L + + + +IKE E+ ED+ EEI E R+ E
Sbjct: 900 EAEGLADAEERCDQLIKTKIQLEAKIKEVTER---AEDE------EEINAELTAKKRKLE 950
Query: 794 NKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLK 853
++ + +++ID L K + + + + +K ++ L ETI K +++ L+
Sbjct: 951 DECSELKKDIDDLELTLAKVEKEKHA----TENKVKNLTEEMAGLDETIAKLTKEKKALQ 1006
Query: 854 KAEENCLQTVNELMAKQQQLKDI---RVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQK 910
+A + QT+++L A++ ++ + ++ + ++ +E+E+K + ++R KL+
Sbjct: 1007 EAHQ---QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG 1063
Query: 911 EVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDD--IIEVEMGTEAESTQATIDI 968
++ Q S+ EK L K ++ EI L ++D + +++ + + QA I+
Sbjct: 1064 DLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE- 1122
Query: 969 YEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLK 1028
E EE E + +S KA + ++ L + +++ N + +
Sbjct: 1123 -ELEEEIEAERAS---RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178
Query: 1029 TVRDKFQESTDAFEASRKEAR 1049
+R +E+T EA+ R
Sbjct: 1179 KMRRDLEEATLQHEATAATLR 1199
Score = 48.1 bits (113), Expect = 5e-05
Identities = 72/333 (21%), Positives = 141/333 (42%), Gaps = 44/333 (13%)
Query: 141 ESISVKKPKER--TQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNK--------KK 190
++I +KK E + +++ + + E R Q +D Q + + K+
Sbjct: 1616 DAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKE 1675
Query: 191 NIAAERRQAKLEKEEAERYQSLLEELKMNK--IQLQLFQLYHNEKKIHLLNTKLEHVNRD 248
+A R+A L + E E ++ LE+ + ++ + +L + +H NT L + +
Sbjct: 1676 QLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK 1735
Query: 249 LSVKRESLSHH-ENIVK----ARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKE 303
L + E+I++ A +K +T E+ K +T + +R + K E
Sbjct: 1736 LETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK--KNME 1793
Query: 304 NTSHHLK-KLDVAKK-SIKDSEKQCSKQEDDIKALETEL-------ADLDAAWRSFEKQI 354
T L+ +LD A++ ++K +KQ K E ++ LE E+ A+ R E+++
Sbjct: 1794 QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRV 1853
Query: 355 EEEILHKKRD----------IELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDE 404
+E + D ++ +++ YK E+ ++ T + KLQ E + E
Sbjct: 1854 KELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAE 1913
Query: 405 ERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEK 437
ER E Q N ++K + E H K I +
Sbjct: 1914 ERADI-----AESQVNKLRVKSR-EVHTKVISE 1940
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 94.7 bits (234), Expect = 5e-19
Identities = 182/994 (18%), Positives = 394/994 (39%), Gaps = 154/994 (15%)
Query: 131 QNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKK 190
+ C Q +E ++ + + + +LI + + ++ L EE ++ K
Sbjct: 866 EECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKI 925
Query: 191 NIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQL-----------YHNEKKIHLLN 239
+ A ++ EE E S L + K++ + F+L +EK+
Sbjct: 926 QLEARVKELSERVEEEEEINSELTA-RGRKLEDECFELKKEIDDLETMLVKSEKEKRTTE 984
Query: 240 TKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYI 299
K++++ ++ E +S K ++ H L E++L S+ N K Q +
Sbjct: 985 HKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKA-NLKLEQQV 1043
Query: 300 KAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEIL 359
E L+ +K+ + E++ K E ++K + +L+++ ++ + EE+
Sbjct: 1044 DELEGA------LEQERKARMNCERELHKLEGNLKLNRESMENLESS----QRHLAEELR 1093
Query: 360 HKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQG 419
K+ ++ S+++ K L Q++K V + Q++ L+ E+L E+ +++
Sbjct: 1094 KKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLK-------EKLEAERTTRAKMER 1146
Query: 420 NLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKK---------QQEETL----------- 459
+ + + D +R+E++ + ++ K+++ +E TL
Sbjct: 1147 ERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKK 1206
Query: 460 -----VDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEV-LEHLKRLYPD 513
+ E+E + + ++L +S+LQ D Q RA+ E L LY +
Sbjct: 1207 RHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEE 1266
Query: 514 SVFGRLFDLCHPIHKKYQLA------VTKVF---GRFI------TAIVVASEKVAKDCIR 558
RL + + K QLA TK++ G F+ A++ + + R
Sbjct: 1267 ----RLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTR 1322
Query: 559 FLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLV 618
+++ R + E + K + L+ + D+++ Q+ + ++V
Sbjct: 1323 QIEDLRGQLEK-------ETKSQSALAHALQKAQRDCDLLREQYEEEQEV---------- 1365
Query: 619 CETMEEARHIALSGPER-QKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDR 677
E R ++ E Q + + + ++ + +L R + E + +
Sbjct: 1366 --KAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKEL--AIRLQEAAEAMGVANA 1421
Query: 678 RSQKIQELKGLMKTLRKE--TDLKQIQTLIQGTQTRLKYSQNELEMIKKKH------LVA 729
R+ ++ + ++ + +DL ++++ + S L K+KH L A
Sbjct: 1422 RNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDA 1481
Query: 730 FYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENI 789
+E L +ELL +++ G + +R K QE+I + + + + G +N+
Sbjct: 1482 SQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVRE------GTKNL 1535
Query: 790 REFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDI 849
E E VK+ E++KT + V LE + L++ +KI + + + ++
Sbjct: 1536 TEMEK--VKKL---------IEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAEL 1584
Query: 850 DHLKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQ 909
+ +L K +++++ R Q + + +Q+ ++ E K + V R K++
Sbjct: 1585 E-------------RKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKME 1631
Query: 910 KEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIY 969
+++ ++ L + I+I L LDD STQ D+
Sbjct: 1632 EDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDD-----------STQLNSDLK 1680
Query: 970 EKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKT 1029
E+ E S L+ +L+ L+S QE R L S+E++L T NL +N
Sbjct: 1681 EQVAVAERRNSLLQSELEDLRSLQEQTERGRRL-----SEEELLEATERINLFYTQNTSL 1735
Query: 1030 VRDKFQESTDAFEASRKEARL---CRQEFEQVKK 1060
+ K + D ++ + C+ E+ KK
Sbjct: 1736 LSQKKKLEADVARMQKEAEEVVQECQNAEEKAKK 1769
Score = 82.0 bits (201), Expect = 3e-15
Identities = 96/425 (22%), Positives = 195/425 (45%), Gaps = 56/425 (13%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQS----QLQS 739
++K L+K+ ++ ++ Q L+ S+ + E +K K V+ QE++ QLQ+
Sbjct: 847 KIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQ-VSLTQEKNDLILQLQA 905
Query: 740 E---LLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKH 796
E L N+E QC L + + + R+KE E++++ E E ++
Sbjct: 906 EQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEE-----------------EINSEL 948
Query: 797 VKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKA- 855
R ++++ + E +K+ L L S + +K+ L E ++ +EDI L +A
Sbjct: 949 TARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAA 1008
Query: 856 ---EENCLQTVNELMAKQQQLKDI---RVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQ 909
+E QT+++L ++++L + + ++++ +E+ERK + +RE+ KL+
Sbjct: 1009 KVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLE 1068
Query: 910 KEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIY 969
+ + S+E + +L + + +++E+ ++ +E E G A+ Q T+
Sbjct: 1069 GNLKLNRESMENLESSQRHLAEELRKKELEL----SQMNSKVENEKGLVAQ-LQKTV--- 1120
Query: 970 EKEEAFEIDYSSLKEDLKALQSDQ-EIEAHLRLLLQQVASQEDILLKTAAPNLRALENLK 1028
+ + LKE L+A ++ + ++E L Q +A + L + +L LE K
Sbjct: 1121 ---KELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITK 1177
Query: 1029 TVRDKFQESTDAFEASRKEARLCRQEFE----QVKKRRYDLFTQCFEHVSISIDQIYKKL 1084
KFQ+ +EA L FE +KKR D + V ++ Q+ +KL
Sbjct: 1178 KQETKFQK----LHRDMEEATL---HFETTSASLKKRHADSLAELEGQVE-NLQQVKQKL 1229
Query: 1085 CRNNS 1089
++ S
Sbjct: 1230 EKDKS 1234
Score = 78.6 bits (192), Expect = 3e-14
Identities = 168/833 (20%), Positives = 352/833 (42%), Gaps = 91/833 (10%)
Query: 146 KKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERR-QAKLEKE 204
KK E +Q ++ L+ + ++ ++LQ +D K+ + AER +AK+E+E
Sbjct: 1094 KKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDL------KEKLEAERTTRAKMERE 1147
Query: 205 EAERYQSL--LEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENI 262
A+ Q L L E L QL +K+ TK + ++RD+ E+ H E
Sbjct: 1148 RADLTQDLADLNERLEEVGGSSLAQLEITKKQ----ETKFQKLHRDME---EATLHFETT 1200
Query: 263 VKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDS 322
+ KK H +L+ + L+ V+ L + + ++ ++++ AK + +
Sbjct: 1201 SASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKAN---A 1257
Query: 323 EKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKE-- 380
EK C+ E+ L A LD Q+ ++ +K + E+ + R E KE
Sbjct: 1258 EKLCTLYEE---RLHEATAKLDKV-----TQLANDLAAQKTKLWSESGEFLRRLEEKEAL 1309
Query: 381 --QVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKK-RIEK 437
Q+ ++ + T+Q+E L+ + + + + + + Q + ++EQ E+ ++ + E
Sbjct: 1310 INQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAEL 1369
Query: 438 LEEYTKTCMDCLKEKKQQEETLV---DEIEKTKS----RMSEFNEELNLIRSELQNAGID 490
+K + ++ + + E ++ +++E K R+ E E + + + +NA ++
Sbjct: 1370 HRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANA--RNASLE 1427
Query: 491 THEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASE 550
+ Q + + L L ++ S RL + LA K A++ AS+
Sbjct: 1428 RARHQLQLELGDALSDLGKVR--SAAARLDQ--KQLQSGKALADWKQKHEESQALLDASQ 1483
Query: 551 K-VAKDCIRFLKEERAEPETFLALDYL--DIKPINERLRELKGCKMVIDVIKTQFPQLKK 607
K V LK + E+ + + L + K + E + L T+ ++KK
Sbjct: 1484 KEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKK 1543
Query: 608 VIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWD 667
+I+ V T+EE ER ++ L L L ++L+ K D
Sbjct: 1544 LIEEEKTEVQV--TLEETE----GALERNESKILHFQLELLEA-----KAELERKLSEKD 1592
Query: 668 EKELKNLRDRRSQKIQELKGLMKTLRK------------ETDLKQIQTLIQGTQTRLKYS 715
E E++N R ++ I L+ + + K E DL +++ + ++ +
Sbjct: 1593 E-EIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEA 1651
Query: 716 QNELEM--IKKKHLVAFYQEQSQLQSEL---LNIESQCIMLSEGIKERQRRIKEFQEKID 770
L I+ K L + +QL S+L + + + L + E R ++E E+
Sbjct: 1652 TKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGR 1711
Query: 771 KVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKK 830
++ ++ E I + + K++ E D R++ K+ + + + + KK
Sbjct: 1712 RLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQ--KEAEEVVQECQNAEEKAKK 1769
Query: 831 KLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNEL---MAKQQQL------KDIRVTQN 881
+ L E ++K + I HL++ EN QT+ +L +A+ +Q+ K I+ +
Sbjct: 1770 AAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLE- 1828
Query: 882 SSAEKVQTQIEEERKKFLAVDREVGKLQK--EVVSIQTSLEQKRLEKHNLLLD 932
S +++ ++E E ++ R +L++ + ++ Q ++K L + +D
Sbjct: 1829 SRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMD 1881
Score = 73.2 bits (178), Expect = 1e-12
Identities = 93/401 (23%), Positives = 177/401 (44%), Gaps = 41/401 (10%)
Query: 118 IAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQK 177
+ E+EK+ +++ + V Q T+E + ++ + EL+ E +RKL +
Sbjct: 1535 LTEMEKVKKLIEEEKTEV-QVTLEETEGALERNESKI---LHFQLELLEAKAELERKLSE 1590
Query: 178 AEEDAQFNFNKKKNIAAERRQAKLEKE-----EAERYQSLLEELKMNKIQLQLF----QL 228
+E+ + NF +K+ + Q+ L+ E E R + +EE +N+++LQL Q+
Sbjct: 1591 KDEEIE-NFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEE-DLNEMELQLSCANRQV 1648
Query: 229 YHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQ-------QTE 281
K + L +++ + L + S + V ++ + +L +L+ QTE
Sbjct: 1649 SEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTE 1708
Query: 282 KELK-SVETLLNQKRPQYIKAKENTS--HHLKKL--DVAK--KSIKDSEKQCSKQEDDIK 334
+ + S E LL + +NTS KKL DVA+ K ++ ++C E+ K
Sbjct: 1709 RGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAK 1768
Query: 335 ALETELADLDAAWRSFEKQIEEEILHKKRDIE-LEASQLDRYKELKEQVRKKVATMTQQL 393
E A+L K+ ++ I H +R E +E + D K L E + + +Q+
Sbjct: 1769 KAAIEAANLSEEL----KKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQI 1824
Query: 394 EKLQWEQKTDEERLAFEKRRHGEVQGN-------LKQIKEQIEDHKKRIEKLEEYTKTCM 446
+KL+ + E L E RR E Q +K++ Q E+ KK + +++
Sbjct: 1825 QKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQ 1884
Query: 447 DCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNA 487
++ KQQ E + + S+ + ELN ++ + A
Sbjct: 1885 LKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVA 1925
Score = 65.9 bits (159), Expect = 2e-10
Identities = 146/829 (17%), Positives = 307/829 (37%), Gaps = 138/829 (16%)
Query: 263 VKARKKEHGMLTRQLQQTE---KELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSI 319
V K+E L + L+++E +ELK+ + L Q++ I + L ++ + +
Sbjct: 861 VAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWL 920
Query: 320 KDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELK 379
S+ Q + ++ E ++++ + +++E+E K++I+ + L + ++ K
Sbjct: 921 IKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEK 980
Query: 380 EQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLE 439
KV +T+++E L + + H + +L +E++ K KLE
Sbjct: 981 RTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLE 1040
Query: 440 EYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQK 499
+ L+++++ E+ K + + E + + S + H + +K
Sbjct: 1041 QQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQR------HLAEELRK 1094
Query: 500 RAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRF 559
+ L + + K + K T I EK+ +
Sbjct: 1095 KELELSQMNSKVENE-------------KGLVAQLQKTVKELQTQIKDLKEKLEAERTTR 1141
Query: 560 LKEERAEPETFLALDYLDIKPINERLRELKGCKMV-IDVIKTQFPQLKKVIQFVCGNGLV 618
K ER + D+ +NERL E+ G + +++ K Q + +K+ +
Sbjct: 1142 AKMERERADLTQ-----DLADLNERLEEVGGSSLAQLEITKKQETKFQKLHR-------- 1188
Query: 619 CETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRR 678
MEEA TL ++ S L+ R
Sbjct: 1189 --DMEEA------------------TLHFETTSAS--------------------LKKRH 1208
Query: 679 SQKIQELKGLMKTLRK-----ETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQE 733
+ + EL+G ++ L++ E D +Q + TR++
Sbjct: 1209 ADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVE-------------------- 1248
Query: 734 QSQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFE 793
Q+ N E C + E R+ E K+DKV ++ + + +
Sbjct: 1249 --QMTRAKANAEKLCTLYEE-------RLHEATAKLDKVTQ-----LANDLAAQKTKLWS 1294
Query: 794 N--KHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDH 851
+ ++R +E + + ++K+ Q+E R L+K+ + L +QK D D
Sbjct: 1295 ESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDL 1354
Query: 852 LKKAEENCLQTVNELMAKQQQLKDIRVTQNSSAEK---VQTQIEEERKKFLAVDREVGKL 908
L++ E + EL ++ V E +T+ E+ KK LA+ +
Sbjct: 1355 LREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEAAE 1414
Query: 909 QKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMG-------TEAES 961
V + + + ++ + L L + D+ + + + D +++ G + E
Sbjct: 1415 AMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEE 1474
Query: 962 TQATIDIYEKE-EAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPN 1020
+QA +D +KE +A + LK + QE LQ+ S ++ N
Sbjct: 1475 SQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKN 1534
Query: 1021 LRALENLK--------TVRDKFQESTDAFEASRKEARLCRQEFEQVKKR 1061
L +E +K V+ +E+ A E R E+++ + E ++ +
Sbjct: 1535 LTEMEKVKKLIEEEKTEVQVTLEETEGALE--RNESKILHFQLELLEAK 1581
Score = 65.5 bits (158), Expect = 3e-10
Identities = 70/310 (22%), Positives = 154/310 (49%), Gaps = 19/310 (6%)
Query: 157 EISTSGELIGEYEEKKRKLQKAEEDA-QFNFNKKKNIAAERRQAKLEKEEAERYQSLLEE 215
++S + + +G+ + + + LQ +D+ Q N + K+ +A R+ L + E E +SL E+
Sbjct: 1647 QVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQ 1706
Query: 216 LKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTR 275
+ + +L +L ++I+L T+ N L +++ L E V +KE + +
Sbjct: 1707 TERGR-RLSEEELLEATERINLFYTQ----NTSLLSQKKKL---EADVARMQKEAEEVVQ 1758
Query: 276 QLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKL-DVAKKSIKDSEKQCSKQED-DI 333
+ Q E++ K + + +K K++T HL++ + +++I D +K+ ++ E +
Sbjct: 1759 ECQNAEEKAKKA-AIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMAL 1817
Query: 334 KALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDR-YKELK---EQVRKKVATM 389
++ L++ R E ++E EI + + + A +L+R KEL E+ +K ++ M
Sbjct: 1818 MGSRKQIQKLESRVRELEGELEGEI-RRSAEAQRGARRLERCIKELTYQAEEDKKNLSRM 1876
Query: 390 TQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCL 449
Q++KLQ + + ++++ + + + K+ + ++ + K+R E E
Sbjct: 1877 QTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKA 1936
Query: 450 KE--KKQQEE 457
+E KK QEE
Sbjct: 1937 REFGKKVQEE 1946
Score = 54.3 bits (129), Expect = 7e-07
Identities = 156/799 (19%), Positives = 307/799 (38%), Gaps = 138/799 (17%)
Query: 163 ELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEA--ERYQSLLEELKMNK 220
E+ + E K +KL + E+A +F +R L + E E Q + ++L+ +K
Sbjct: 1174 EITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDK 1233
Query: 221 IQLQL----------------------FQLYHNEKKIHLLNTKLEHVNR---DLSVKRES 255
LQL LY E+++H KL+ V + DL+ ++
Sbjct: 1234 SDLQLEVDDLLTRVEQMTRAKANAEKLCTLY--EERLHEATAKLDKVTQLANDLAAQKTK 1291
Query: 256 LSHHENIVKARKKEHGMLTRQLQQTEKEL-KSVETLLNQKRPQYIKAKENTSHHLKKLDV 314
L R +E L QL + + + +E L Q + K++ +H L+K
Sbjct: 1292 LWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKE-TKSQSALAHALQK--- 1347
Query: 315 AKKSIKDSEKQCSKQEDDIKA-LETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLD 373
A++ D ++ ++E ++KA L L+ ++A + + E ++ + D+E +L
Sbjct: 1348 AQRDC-DLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELA 1406
Query: 374 -RYKELKEQV---RKKVATMTQQLEKLQWE---------------------QKTDEERLA 408
R +E E + + A++ + +LQ E Q + LA
Sbjct: 1407 IRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALA 1466
Query: 409 FEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEE-YTKTCMD---CLKEKKQQEETL----- 459
K++H E Q L +++++ + KL+ Y ++ + +E K +E +
Sbjct: 1467 DWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTN 1526
Query: 460 --------VDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLY 511
+ E+EK K + E E+ + E + A ++ +E K + E+LE L
Sbjct: 1527 QVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGA-LERNESKILHFQLELLEAKAEL- 1584
Query: 512 PDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLK---EERAEPE 568
+ + +K Q + + + + + K + R K E+ E E
Sbjct: 1585 -ERKLSEKDEEIENFRRKQQCTIDS-----LQSSLDSEAKSRIEVTRLKKKMEEDLNEME 1638
Query: 569 TFLALDYLDIKPINERLREL----KGCKMVIDVIKTQFPQLKKVIQFV-CGNGLVCETME 623
L+ + + L +L K +M +D LK+ + N L+ +E
Sbjct: 1639 LQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELE 1698
Query: 624 EARHIA--------LSGPERQKTVALDGTLFLKSGVISGGSSDLKYK-ARCWDE-----K 669
+ R + LS E + + ++ + L+ AR E +
Sbjct: 1699 DLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQ 1758
Query: 670 ELKNLRDRRSQKIQELKGLMKTLRKETDL--------KQIQTLIQGTQTRLKYSQNELEM 721
E +N ++ + E L + L+K+ D + ++ I Q RL ++ M
Sbjct: 1759 ECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALM 1818
Query: 722 IKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKE--FQEKIDKVEDDIFQH 779
+K + +L+ EL + G + +R IKE +Q + DK
Sbjct: 1819 GSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDK-------- 1870
Query: 780 FCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLK 839
+N+ + + K Q ++ + + E +T+ N L S KK+ +++N +K
Sbjct: 1871 -------KNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYL----SKYKKQQHELNEVK 1919
Query: 840 ETIQKGSEDIDHLK-KAEE 857
E + ++ LK KA E
Sbjct: 1920 ERAEVAESQVNKLKIKARE 1938
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 94.0 bits (232), Expect = 8e-19
Identities = 214/1104 (19%), Positives = 455/1104 (41%), Gaps = 167/1104 (15%)
Query: 104 EFRFNDNLVSRSVYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGE 163
EF+ N+ L+++ +EK+ + N F TVE + + + Q +EIS E
Sbjct: 384 EFKINELLLAKEEQGCVIEKLKSELAGLN-KQFCYTVEQHNREVQSLKEQHQKEISELNE 442
Query: 164 LIGEYEEKKR---------------KLQKAEEDAQFNFNKKKNIAAERRQAKLEKEE--- 205
EK++ LQ+ +++A N+ + I E Q +L +
Sbjct: 443 TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIM-EILQTELGESAGKI 501
Query: 206 AERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNT--KLEHVNRDLSVKRESLSHHENIV 263
++ ++S+ ++ + +LQ +K LL T +L+ N L ++E + EN +
Sbjct: 502 SQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTI 561
Query: 264 KARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSE 323
K ++++G+ L Q + LK +E +N E + KL + + + +
Sbjct: 562 KNLQEKNGVYLLSLSQRDTMLKELEGKINS-------LTEEKDDFINKLKNSHEEMDNFH 614
Query: 324 KQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVR 383
K+C ++E L EL + ++E+++ +E + D+ + E++
Sbjct: 615 KKCEREE----RLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLM 670
Query: 384 KKVATMTQQLEKLQWEQKT---DEERLAFEKR---RHGEVQGNLKQ---IKEQIEDHKKR 434
++ +++ E L E K+ + +L+ EK+ R EV + K+ +KE I +K+
Sbjct: 671 VQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKK 730
Query: 435 IEKLEEYTKTCMDCLKEKKQQE----ETLVDEIEKTKSRMSEFNEELNLIRSELQNAG-- 488
++ + E L+ ++ Q+ L +++ S +SE +EE +++ + LQ G
Sbjct: 731 LQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV-NVLQAVGES 789
Query: 489 -IDTHEGK------RQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRF 541
+E K R +K E+ + +K L +SV C +
Sbjct: 790 LAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQ-----CEELKS------------- 831
Query: 542 ITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQ 601
++ + K +R EE + L D L++K NE+ R L+ ++I V +
Sbjct: 832 ----LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTR-LENQNLLIQVEEVS 886
Query: 602 FPQLKKVIQ------FVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGG 655
K I F+ + + +E+ R + + L +L V +
Sbjct: 887 QTCSKSEIHNEKEKCFIKEHENLKPLLEQKE----LRDRRAELILLKDSLAKSPSVKNDP 942
Query: 656 SSDLK--------YKARCWDEKE-----------LKNLRDRRSQKIQELKGLMKTLRKET 696
S +K + C +++E K D ++ Q +K +++LR E
Sbjct: 943 LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK 1002
Query: 697 DL--KQIQTLIQGTQTR----LKYS-QNELEMIKKKHLVAFYQEQSQLQSELLNIESQCI 749
D ++ LIQG ++ L+Y Q+E ++K+ F L +L N QC
Sbjct: 1003 DQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCE 1062
Query: 750 MLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLE 809
++ ++ RI+ Q +E I + + V+ +E E + ++++Q+I +
Sbjct: 1063 TINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVD--KELEAEKLQKEQKIKEHATT 1120
Query: 810 FEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQK----GSEDIDH---LKKAEENCLQT 862
+ + L VQL+ + L+K + ++ +K+ Q+ E D+ +K+ +
Sbjct: 1121 VNELE-ELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNK 1179
Query: 863 VNELMAKQQQLKDIRVTQNSSAEKV---QTQIEEERKKFLAVDREVGKLQKEVVSIQTSL 919
N++ +Q++K + Q + E++ Q+ +++ +K + + + K +KE+
Sbjct: 1180 NNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA------ 1233
Query: 920 EQKRLEKHNLLLDCKV--------QDIEIILLS----GSLDDIIEVEMGTEAESTQATID 967
+ K+ E +L+L + Q +E+ + S I + T AE Q T+
Sbjct: 1234 DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLS 1293
Query: 968 IYEKEEAFEIDYSSLKEDLKALQSDQ----------EIEAHLRLLLQQVASQEDILLKTA 1017
Y++ ++L+E+ +A +++Q ++ H L Q+ S + A
Sbjct: 1294 AYQQR------VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGA 1347
Query: 1018 APNLRALENL-KTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSIS 1076
LE L ++ K Q+S + + + E + + E + + +R + + +
Sbjct: 1348 KQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEA-- 1405
Query: 1077 IDQIYKKLCRNNSAQAFLSPENPE 1100
++ +KLC S + E+ +
Sbjct: 1406 --ELREKLCSIQSENMMMKSEHTQ 1427
Score = 90.9 bits (224), Expect = 7e-18
Identities = 208/1029 (20%), Positives = 435/1029 (42%), Gaps = 164/1029 (15%)
Query: 116 VYIAELEKIGIIVKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKL 175
VY+ L + ++K +G + S++ +E+ F ++ S E + + +K +
Sbjct: 570 VYLLSLSQRDTMLKE-----LEGKINSLT----EEKDDFINKLKNSHEEMDNFHKKCERE 620
Query: 176 Q--------KAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQ 227
+ K E+ Q+N ++ + LE+ E+ Q+ + K+ K+ +Q+
Sbjct: 621 ERLILELGKKVEQTIQYNSELEQKV--NELTGGLEETLKEKDQN---DQKLEKLMVQMKV 675
Query: 228 LYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARK-----KEH-GMLTRQLQQTE 281
L +++ + L N LS +++ LS + ++K KEH L ++LQ
Sbjct: 676 LSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMV 735
Query: 282 KELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELA 341
+E ++ LL ++ Q + K LK++ + +DSE++ + ++A+ LA
Sbjct: 736 EEQDNLNKLLENEQVQKLFVKTQLYGFLKEM--GSEVSEDSEEK--DVVNVLQAVGESLA 791
Query: 342 DLDAAWRSFEKQIEEEILHKKRDIE-LEASQLDRYKELKEQVR---KKVATMTQQLEKLQ 397
++ + Q +E++L +++I+ L+ + + +ELK +R ++ + ++LE++Q
Sbjct: 792 KINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQ 851
Query: 398 WEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEE 457
E++ + L E + E K ++E+ I+ +EE ++TC + ++E+
Sbjct: 852 SEKEALQSDL-LEMKNANE--------KTRLENQNLLIQ-VEEVSQTCSKS-EIHNEKEK 900
Query: 458 TLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFG 517
+ E E K + + +EL R+EL + K + + L +K L +
Sbjct: 901 CFIKEHENLKPLLEQ--KELRDRRAEL--ILLKDSLAKSPSVKNDPLSSVKEL--EEKIE 954
Query: 518 RLFDLCHPIHKKY-QLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYL 576
L C +K ++ + V + + K+ + L+ E+ + +
Sbjct: 955 NLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQ 1014
Query: 577 DIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVC----GNGLVCETMEEARHIALSG 632
+ L E + +DV K + + I+ + + L CET+ L+
Sbjct: 1015 GAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLA- 1073
Query: 633 PERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTL 692
R +T+ + L L+ ++ +A+ +KEL+ + ++ QKI+E +
Sbjct: 1074 --RIETLQSNAKL-LEVQILE------VQRAKAMVDKELEAEKLQKEQKIKEHATTVN-- 1122
Query: 693 RKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLS 752
+L+++Q +Q + +L+ + ELE++KK Q+ L+N+E
Sbjct: 1123 ----ELEELQVQLQKEKKQLQKTMQELELVKK----------DAQQTTLMNME------- 1161
Query: 753 EGIKERQRRIKEFQEKI----DKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRL 808
I + +R +KE +K+ +K+ED E E K K++QE L
Sbjct: 1162 --IADYERLMKELNQKLTNKNNKIED---------------LEQEIKIQKQKQE----TL 1200
Query: 809 EFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQT--VNEL 866
+ E + +VQ +Y + K K + T KE + DHL LQ EL
Sbjct: 1201 QEEITSLQSSVQ-QYEEKNTKIKQLLVKTKKELADSKQAETDHL------ILQASLKGEL 1253
Query: 867 MAKQQ-------QLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV------- 912
A QQ QL +I ++ E ++T E+ ++ A + V LQ+E
Sbjct: 1254 EASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQ 1313
Query: 913 VSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKE 972
++ + E ++ HN+L K + + G+ + +EM + Q I + + +
Sbjct: 1314 ATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLID----QLKIKLQDSQ 1369
Query: 973 EAFEIDYSSLKEDLKALQSDQE--IEAHLRLLLQQVASQEDILLKTAAPN----LRALEN 1026
+I+ S +L+ LQS+ + +E H ++L + V+ + ++ K + + E+
Sbjct: 1370 NNLQINVS----ELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425
Query: 1027 LKTV----------RDKFQESTDAF-EASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSI 1075
+TV R+ F++ E RK +Q+ +++ + + L + +
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPV 1485
Query: 1076 SIDQIYKKL 1084
S Q K L
Sbjct: 1486 SSQQSLKNL 1494
Score = 90.1 bits (222), Expect = 1e-17
Identities = 200/980 (20%), Positives = 406/980 (41%), Gaps = 138/980 (14%)
Query: 157 EISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLE--KEEAERYQSLLE 214
E+S + E+ +KLQ+ E + F ++ ++ A + KE + Q+++E
Sbjct: 165 ELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE 224
Query: 215 ------ELKMNKIQLQLFQLYH-NEKKIHLLNTKLEHVNRDLSVKRESLSH-HENIVKAR 266
+ +N +Q +L QL +++++ L ++E ++ + L+ EN+VK
Sbjct: 225 ANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQC 284
Query: 267 KKEHGMLTRQLQQTEKELKSVETLLNQKRPQY-IKAKENTSHHLKKLDVAKKSIKDSEKQ 325
+ + ++ + + L+ + NQ I +ENT + ++ K ++D+ K+
Sbjct: 285 EASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVE-QVVNEKVKHLEDTLKE 343
Query: 326 CSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKK 385
Q +K T + +L + I++E H++ D+E + ++L KE + V
Sbjct: 344 LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV--- 400
Query: 386 VATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTC 445
+EKL+ E ++ + +H +LK E H+K I +L E
Sbjct: 401 -------IEKLKSELAGLNKQFCYTVEQHNREVQSLK------EQHQKEISELNE----- 442
Query: 446 MDCLKEKKQQEETLVDEIEKTKSRMSEFNEE-----LNLIRSELQNAGIDTHEGKRQQKR 500
L + ++++ TL+ EI+ K + +E LN + T G+ K
Sbjct: 443 -TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKI 501
Query: 501 AEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFL 560
++ E +K+ V H + +K + A T+ A++ ++ + + L
Sbjct: 502 SQEFESMKQQQASDV--------HELQQKLRTAFTEK-----DALLETVNRLQGENEKLL 548
Query: 561 KEERAEPETFLALDYLDIK------PINER---LRELKGCKMVIDVIKTQF-PQLKKVIQ 610
++ PE + L K +++R L+EL+G + K F +LK +
Sbjct: 549 SQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHE 608
Query: 611 FVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKE 670
+ CE E R I G + ++T+ + L K ++GG E+
Sbjct: 609 EMDNFHKKCE--REERLILELGKKVEQTIQYNSELEQKVNELTGGL-----------EET 655
Query: 671 LKNLRDRRSQKIQELKGLMKTLRKETDL--KQIQTLIQ------------GTQTRLKYSQ 716
LK +D+ QK+++L MK L ++ ++ ++++L + + SQ
Sbjct: 656 LKE-KDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQ 714
Query: 717 NELEMIK------KKHLVAFYQEQSQLQSELLNIESQCIMLSEG----IKERQRRIKEFQ 766
E ++K +K L +EQ L L N + Q + + +KE + E
Sbjct: 715 KEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDS 774
Query: 767 EKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKTRLN----VQLE 822
E+ D V + + +G E++ + + + D+K LE EK+ L VQ E
Sbjct: 775 EEKDVV------NVLQAVG-ESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCE 827
Query: 823 YSRS----------HLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQ 872
+S L+K+L +I + KE +Q D+ +K A E L+ + ++
Sbjct: 828 ELKSLLRDYEQEKVLLRKELEEIQSEKEALQ---SDLLEMKNANEKTRLENQNLLIQVEE 884
Query: 873 LKDIRVTQNSSAEKVQTQIEE-ERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLL 931
+ EK + I+E E K L +E+ + E++ ++ SL + K++ L
Sbjct: 885 VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS 944
Query: 932 DCKVQDIEIILLSGSLDDIIEV--EMGTEAESTQATIDIYEKEEAFEIDYSSLKEDLKAL 989
K + +I L + E ++ A + +D KE ++KE+L++L
Sbjct: 945 SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKET------QTVKEELESL 998
Query: 990 QSDQ-EIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEA 1048
+S++ ++ A +R L+Q S +++LL+ + E L +++ E ++
Sbjct: 999 RSEKDQLSASMRDLIQGAESYKNLLLEYE----KQSEQLDVEKERANNFEHRIEDLTRQL 1054
Query: 1049 RLCRQEFEQVKKRRYDLFTQ 1068
R + E + DL +
Sbjct: 1055 RNSTLQCETINSDNEDLLAR 1074
Score = 80.9 bits (198), Expect = 7e-15
Identities = 205/1039 (19%), Positives = 431/1039 (41%), Gaps = 171/1039 (16%)
Query: 77 SASVKIIYVEE---SGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAELEK-IGIIVKAQN 132
SA VK +Y E S E+K +R + S+ ++++ + +I +LEK + ++V+ Q+
Sbjct: 684 SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQ---KEDVILKE-HITQLEKKLQLMVEEQD 739
Query: 133 CLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKK---RKLQKAEEDAQFNFNKK 189
L +E+ V+K +TQ + + G + E E+K LQ E +K
Sbjct: 740 NL--NKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEK 797
Query: 190 KNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDL 249
N+A +R + LE E+ + L EE + +L+ + ++K+ LL +LE + +
Sbjct: 798 CNLAFQRDEKVLELEK--EIKCLQEESVVQCEELKSLLRDYEQEKV-LLRKELEEIQSEK 854
Query: 250 SVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHL 309
+ L +N + + E+ L Q+++ + E + N+K +IK EN L
Sbjct: 855 EALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSE-IHNEKEKCFIKEHEN----L 909
Query: 310 KKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEA 369
K L + +K ++D + +D + + D S K++EE+I + +++ + +
Sbjct: 910 KPL-LEQKELRDRRAELILLKDSLAKSPSVKNDP----LSSVKELEEKIENLEKECKEKE 964
Query: 370 SQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIE 429
++++ K + + +K +L+ + E +T +E L + ++ +++ + + E
Sbjct: 965 EKINKIKLVAVKAKK-------ELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
Query: 430 DHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGI 489
+K + L+ +KQ E+ V+ K R + F + + +L+N+ +
Sbjct: 1018 SYKNLL-------------LEYEKQSEQLDVE-----KERANNFEHRIEDLTRQLRNSTL 1059
Query: 490 DTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVAS 549
+ ++L ++ L ++ K+ I + A
Sbjct: 1060 QCETINSDNE--DLLARIETLQSNA---------------------KLLEVQILEVQRAK 1096
Query: 550 EKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMVIDVIKTQFPQLKKVI 609
V K+ L+ E+ + E + + + E +L+ K + + +KK
Sbjct: 1097 AMVDKE----LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDA 1152
Query: 610 QFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWD-- 667
Q ME A + L QK L K+ I ++K + + +
Sbjct: 1153 QQT-----TLMNMEIADYERLMKELNQK-------LTNKNNKIEDLEQEIKIQKQKQETL 1200
Query: 668 EKELKNLR------DRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEM 721
++E+ +L+ + ++ KI++L L+KT ++ D KQ +T Q LK ELE
Sbjct: 1201 QEEITSLQSSVQQYEEKNTKIKQL--LVKTKKELADSKQAETDHLILQASLK---GELEA 1255
Query: 722 IKKKHLVAFYQEQ-SQLQSELLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHF 780
+++ V Y+ Q +++ SE I L ++ QR + +Q+++ ++++
Sbjct: 1256 SQQQ--VEVYKIQLAEITSEKHKIHEH---LKTSAEQHQRTLSAYQQRVTALQEECRAAK 1310
Query: 781 CEEIGVENIREFENKHVK--------RQQEIDQKRLEFEKQKT--------RLNVQLEYS 824
E+ V + EFE+ V+ + + + Q E KQ+ +L ++L+ S
Sbjct: 1311 AEQATVTS--EFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS 1368
Query: 825 RSHLKKKLNKINTLK---------------ETIQKGSEDIDHLKKAE-ENCLQTVNELMA 868
+++L+ ++++ TL+ ET+ K +E + L + EN +
Sbjct: 1369 QNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQT 1428
Query: 869 KQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV------------VSIQ 916
Q V +NS ++V+ EE RK + +++ K++ ++ VS Q
Sbjct: 1429 VSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQ 1488
Query: 917 TSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFE 976
SL+ R E+ N D + D+ + E G E T++ ++ E
Sbjct: 1489 QSLKNLR-ERRN--TDLPLLDMHTVTR--------EEGEGMETTDTESVSSASTYTQSLE 1537
Query: 977 IDYSSLKEDLK-----ALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVR 1031
+S + L+ A + +E+ L + +L +T A N +E +K ++
Sbjct: 1538 QLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLK 1597
Query: 1032 DKFQESTDAFEASRKEARL 1050
+ + E + A L
Sbjct: 1598 SEIRRLERNQEREKSAANL 1616
Score = 77.4 bits (189), Expect = 8e-14
Identities = 172/895 (19%), Positives = 379/895 (42%), Gaps = 147/895 (16%)
Query: 260 ENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLK----KLDVA 315
E+++K KK+ ++ + + + K +E L ++ E T +K +LD
Sbjct: 28 EDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKP------VTEGTGDIIKALTERLDAL 81
Query: 316 KKSIKDSEKQC-SKQEDDIKALETELADLDAAWRSFEKQIEEEILHKKRDIELEASQLDR 374
++E+QC S ++++IK ++ E+ D K++E+ ++ ++IE ++L
Sbjct: 82 LLEKAETEQQCLSLKKENIK-MKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNEL-- 138
Query: 375 YKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKR 434
++ + + A + +QLE+ Q E+L F+ + N+K+++E+IE +
Sbjct: 139 -MAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNS----EDNVKKLQEEIEKIRPG 193
Query: 435 IEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRMSEFNEELNLIRSE-LQNAGIDTHE 493
E+ Y + +D ++K++ T + I + S+ + + +N ++ E LQ I E
Sbjct: 194 FEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQ--HYQKNINSLQEELLQLKAIHQEE 251
Query: 494 GKRQ--QKRAEVLEHLKRLYP-DSVFGRLFDLCHP----IHKKYQLAVTKV--------- 537
K Q A EH + + + L C I KKY+ + +
Sbjct: 252 VKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQ 311
Query: 538 ----------FGRFITAIVVASEKVAKDCIRFLKEERA---------------------- 565
F+ +V K +D ++ L+ + +
Sbjct: 312 DNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQH 371
Query: 566 -EPETFLALDYLDIKPINERL--RELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETM 622
+ E F + L+ K INE L +E +GC VI+ +K++ L K QF C T+
Sbjct: 372 IKDEFFHEREDLEFK-INELLLAKEEQGC--VIEKLKSELAGLNK--QF-------CYTV 419
Query: 623 EE-ARHIALSGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQK 681
E+ R + + QK ++ FL L ++ + E + +NL+ + +
Sbjct: 420 EQHNREVQSLKEQHQKEISELNETFLSDS--EKEKLTLMFEIQGLKE-QCENLQQEKQEA 476
Query: 682 I---QELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQ 738
I + L+ +M+ L+ E + + Q ++ + +++ +++K AF ++ + L+
Sbjct: 477 ILNYESLREIMEILQTELG-ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLE 535
Query: 739 --SELLNIESQCIMLSEGIKERQRRIKEFQEKID------KVEDDIFQHFCEEIG--VEN 788
+ L + + E + E + IK QEK D + + +I E
Sbjct: 536 TVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEE 595
Query: 789 IREFENKHVKRQQEIDQKRLEFEKQK-------TRLNVQLEYSRSHLKKKLNKI-NTLKE 840
+F NK +E+D + E+++ ++ ++Y+ S L++K+N++ L+E
Sbjct: 596 KDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYN-SELEQKVNELTGGLEE 654
Query: 841 TIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKDIRV----TQNSSAEKVQTQIEEERK 896
T+++ ++ L+K L +++++ +++ V +N+ + Q+ + +
Sbjct: 655 TLKEKDQNDQKLEK-----LMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLE 709
Query: 897 KFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMG 956
FL+ +V L++ + ++ L+ E+ NL + + ++ + + L ++ EMG
Sbjct: 710 VFLSQKEDV-ILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLK-EMG 767
Query: 957 TEAESTQATIDIYE------------KEE----AFEIDYS--SLKEDLKALQSDQEIEAH 998
+E D+ EE AF+ D L++++K LQ + ++
Sbjct: 768 SEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCE 827
Query: 999 LRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKEARLCRQ 1053
L + QE +LL+ + LE +++ ++ Q + + ++ RL Q
Sbjct: 828 ELKSLLRDYEQEKVLLR------KELEEIQSEKEALQSDLLEMKNANEKTRLENQ 876
Score = 52.0 bits (123), Expect = 3e-06
Identities = 80/435 (18%), Positives = 188/435 (43%), Gaps = 60/435 (13%)
Query: 671 LKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAF 730
LK + Q++++ M KE + I + + ++ +NEL ++ K +
Sbjct: 95 LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKE-----IENLKNELMAVRSK----Y 145
Query: 731 YQEQSQLQSELLNIESQCIMLSEGIK---ERQRRIKEFQEKIDKVE---DDIFQHFCEEI 784
++++ LQ +L + + LSE +K + +K+ QE+I+K+ ++ + +++
Sbjct: 146 SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQL 205
Query: 785 G------------VENIREFENKHVKR-----QQEIDQKRLEFEKQKTRLNVQLEYSRSH 827
++NI E ++H ++ Q+E+ Q + +++ L Q+E S
Sbjct: 206 DATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKE 265
Query: 828 LKKKLNKINTLKETIQKGSE------------DIDHLKKAEENCLQTVNELMAKQQQLKD 875
+ ++NK+N LKE + K E ++++L+KA N Q Q+
Sbjct: 266 HEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTF 325
Query: 876 IRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKV 935
+ N + ++ ++E + + EV + + ++ + + E + D +
Sbjct: 326 VEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEF 385
Query: 936 QDIEIILL---SGSLDDIIEVEMGTEAESTQATIDIYEKE-----EAFEIDYSSLKEDLK 987
+ E++L G + + ++ E+ + T++ + +E E + + S L E
Sbjct: 386 KINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETF- 444
Query: 988 ALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQESTDAFEASRKE 1047
L ++ + L +Q + Q + L + + E+L+ + + Q T+ E++ K
Sbjct: 445 -LSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQ--TELGESAGK- 500
Query: 1048 ARLCRQEFEQVKKRR 1062
QEFE +K+++
Sbjct: 501 ---ISQEFESMKQQQ 512
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 94.0 bits (232), Expect = 8e-19
Identities = 182/943 (19%), Positives = 393/943 (41%), Gaps = 128/943 (13%)
Query: 190 KNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLE---HVN 246
K+ E+ A + KEE E+ + L + + + +L+ EK + L+ K + V
Sbjct: 845 KSAETEKEMANM-KEEFEKTKEELAKTEAKRKELE-------EKMVTLMQEKNDLQLQVQ 896
Query: 247 RDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTS 306
+ ++ + ++K + + + ++ E E + L +KR K ++ S
Sbjct: 897 AEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKR----KLEDECS 952
Query: 307 HHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLD---AAWRSFEKQIEEEILHKKR 363
K +D + ++ EK+ E+ +K L E+A LD A +K ++E
Sbjct: 953 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012
Query: 364 DIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFE-KRRHGEVQGNLK 422
D+++E +++ + K ++ ++V + LE+ E++L + +R +++G+LK
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQ--------EKKLCMDLERAKRKLEGDLK 1064
Query: 423 QIKEQIEDHKKRIEKLEEYTKTC---MDCLKEKKQQEETLVDEIEKT----KSRMSEFNE 475
+E D + ++L E K M L+ K + E+ L +++K ++R+ E E
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEE 1124
Query: 476 ELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVT 535
E+ R+ A E +R E+ E +RL G ++KK +
Sbjct: 1125 EIEAERASRAKA-----EKQRSDLSRELEEISERL---EEAGGATSAQIEMNKKREAEFQ 1176
Query: 536 KVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKG-CKMV 594
K+ R + + E A L+++ A+ L ++ + ++L + K KM
Sbjct: 1177 KM-RRDLEESTLQHEATAAA----LRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKME 1231
Query: 595 IDVIKTQFPQLKKVIQFVCGNGLVCETMEEA-RHIALSGPERQKTV----ALDGTLFLKS 649
I+ + + + K +C T+E+ I E+Q+ + A L +S
Sbjct: 1232 INDLASNMETVSKA---KANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTES 1288
Query: 650 GVISGGSSDLKYKARCWDEKE-----LKNLRDRRSQKIQELKGLMKTLRKETDLKQIQTL 704
G S R DEK+ L + +Q+I+ELK + L +ET K TL
Sbjct: 1289 GEFS----------RQLDEKDAMVSQLSRGKQAFTQQIEELK---RQLEEETKAKS--TL 1333
Query: 705 IQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSEL---------------LNIESQCI 749
Q+ ++++ ++++++ Y+E+ + ++EL E+ I
Sbjct: 1334 AHALQS----ARHDCDLLREQ-----YEEEQEAKAELQRGMSKANSEVAQWRTKYETDAI 1384
Query: 750 MLSEGIKERQR----RIKEFQEKIDKVEDDI---------FQHFCEE--IGVENIREFEN 794
+E ++E ++ R+++ +E ++ V Q+ E+ I VE
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACI 1444
Query: 795 KHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKK 854
K+Q+ D+ E++++ +LE S+ + ++ +K ++ + ++ LK+
Sbjct: 1445 ALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKR 1504
Query: 855 AEENCLQTVNELMAK-------QQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGK 907
+N Q +++L + +L+ ++ + ++QT +EE + ++ +
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILR 1564
Query: 908 LQKEVVSIQTSLEQKRLEKHNLLLDCKVQDIEII-LLSGSLDDIIEVEMGTEAESTQATI 966
+Q E+ +++ +++K EK L K + ++ + +LD I +
Sbjct: 1565 IQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEG 1624
Query: 967 DIYEKEEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQ-VASQEDILLKTAAPNLRALE 1025
D+ E E E L+ L++ Q I +L L + Q+D+ + A RA
Sbjct: 1625 DLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRA-- 1682
Query: 1026 NLKTVRDKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQ 1068
++ + +E + E + + ++ QE +R L TQ
Sbjct: 1683 --NLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQ 1723
Score = 85.1 bits (209), Expect = 4e-16
Identities = 183/1034 (17%), Positives = 419/1034 (40%), Gaps = 127/1034 (12%)
Query: 74 ISSSASVKIIYVEESGEEKTFARI------IRGGCSEFRFNDNLVSRSVYIAELEKIGII 127
I A +K + EE+ A + + CSE + + + + ++ E EK
Sbjct: 917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATE 976
Query: 128 VKAQNCLVFQGTVESISVKKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFN 187
K +N ++ K KE+ E + + + E+K L KA+ + +
Sbjct: 977 NKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVD 1036
Query: 188 KKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNR 247
+ + ++ ++ E A+R L +LK+ + E + N K + +N
Sbjct: 1037 DLEGSLEQEKKLCMDLERAKR--KLEGDLKLAQ-----------ESTMDTENDK-QQLNE 1082
Query: 248 DLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSH 307
L K +S+ + ++ + L +++++ + ++ +E + +R KA++ S
Sbjct: 1083 KLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142
Query: 308 HLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEIL-HKKRDIE 366
++L+ + ++++ S Q + K E E ++ + +EE L H+
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAE-------FQKMRRDLEESTLQHEATAAA 1195
Query: 367 LEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
L D EL EQ+ + + Q+LEK + E K + LA + + N +++
Sbjct: 1196 LRKKHADSVAELGEQI-DSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCR 1254
Query: 427 QIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDEIEKTKSRM----SEFNEELNLIRS 482
+ED I K K+++++ L++E+ K+R+ EF+ +L+
Sbjct: 1255 TLEDQLSEI--------------KTKEEEQQRLINELSAQKARLHTESGEFSRQLD---- 1296
Query: 483 ELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRL------------FDLCHPIHKKY 530
+ + + + +Q + +E LKR + + DL +++
Sbjct: 1297 --EKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEE 1354
Query: 531 QLAVTKV---FGRFITAIVVASEKVAKDCIRFLKE-ERAEPETFLALDYLDIKPINERLR 586
Q A ++ + + + K D I+ +E E A+ K + +RL+
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK------------KKLAQRLQ 1402
Query: 587 ELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQ-KTVALDGTL 645
+ + ++ + K+ +Q + ++ A IAL +R V +
Sbjct: 1403 DAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQ 1462
Query: 646 FLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKTLRKE-TDLKQIQTL 704
+ +S + ++ + ++KN + ++ LK K L++E +DL + +
Sbjct: 1463 KYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL--TEQI 1520
Query: 705 IQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSEGIKERQRRIKE 764
+G + +ELE +KK+ E+S+LQ+ L E+ ++ + +I
Sbjct: 1521 AEGGK-----HIHELEKVKKQ----LDHEKSELQTSLEEAEA-------SLEHEEGKILR 1564
Query: 765 FQEKIDKVEDDIFQHFCEEIGVENIREFENKH---VKRQQEIDQKRLEFEKQKTRLNVQL 821
Q ++++V+ +I + E+ E + + + H V+ Q + R+ ++
Sbjct: 1565 IQLELNQVKSEIDRKIAEK--DEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKM 1622
Query: 822 EYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQT---VNELMAKQQQLKDIRV 878
E + ++ +LN N ++ +E + +L+ + T +++ + Q LK+
Sbjct: 1623 EGDLNEMEIQLNHAN------RQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLA 1676
Query: 879 TQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVVSIQTSLEQKRLEKHNLLLDCKVQDI 938
A +Q ++EE R +R ++E++ ++ + +L+ K +
Sbjct: 1677 MVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLET 1736
Query: 939 EIILLSGSLDDIIEVEMGTEAESTQATID--IYEKEEAFEIDYSSLKEDLKALQSDQEIE 996
+I + G ++DI++ E ++ +A D + +E E D S+ E +K + +E
Sbjct: 1737 DISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK-----KNME 1791
Query: 997 AHLRLLLQQVASQEDILLKTAAPNLRALENL-----KTVRDKFQESTDAFEASRKEARLC 1051
++ L ++ E + LK ++ LE V + + + +A + RK R
Sbjct: 1792 QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRV 1851
Query: 1052 RQEFEQVKKRRYDL 1065
++ Q ++ R ++
Sbjct: 1852 KELTYQTEEDRKNI 1865
Score = 78.6 bits (192), Expect = 3e-14
Identities = 149/847 (17%), Positives = 342/847 (40%), Gaps = 119/847 (14%)
Query: 146 KKPKERTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFNKKK--NIAAERRQAKLEK 203
KK E + +I L + ++K ++LQ E+ + ++ AE++++ L +
Sbjct: 1086 KKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 204 EEAERYQSLLEELKMNKIQLQLFQLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIV 263
E E + L E Q+++ N+K+ + + + RDL ES HE
Sbjct: 1146 ELEEISERLEEAGGATSAQIEM-----NKKR----EAEFQKMRRDLE---ESTLQHEATA 1193
Query: 264 KARKKEHGMLTRQLQQTEKELKSVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSE 323
A +K+H +L + L+ V+ L +++ + + + +++ + AK + E
Sbjct: 1194 AALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANF---E 1250
Query: 324 KQCSKQED---DIKALETE-----------LADLDAAWRSFEKQIEEE---ILHKKRDIE 366
K C ED +IK E E A L F +Q++E+ + R +
Sbjct: 1251 KMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQ 1310
Query: 367 LEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEERLAFEKRRHGEVQGNLKQIKE 426
Q++ K E+ K +T+ L+ + + E+ E+ E+Q + +
Sbjct: 1311 AFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANS 1370
Query: 427 QI--------EDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVDE---IEKTKSRMSEFNE 475
++ D +R E+LEE K L++ ++ E + + +EKTK R+ E
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVE 1430
Query: 476 ELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFDLCHPIHKKYQLAVT 535
+L +I E NA + K+Q+ +VL K+ Y ++ + +L +
Sbjct: 1431 DL-MIDVERSNAACIALD-KKQRNFDKVLAEWKQKYEET--------------QAELEAS 1474
Query: 536 KVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLALDYLDIKPINERLRELKGCKMV- 594
+ R ++ + + ++ + L+ + E + +I + E++ E G K +
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNL----QQEISDLTEQIAE--GGKHIH 1528
Query: 595 -IDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIALSGPERQKTVALDGTLFLKSGVIS 653
++ +K Q K +Q EE + + + Q +D + K
Sbjct: 1529 ELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEK----- 1583
Query: 654 GGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT-LRKETDLKQIQTLIQGTQTRL 712
++EL L+ + ++ ++ + +R D +I+ ++G +
Sbjct: 1584 --------------DEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEM 1629
Query: 713 KYSQNE-----LEMIK------------KKHLVAFYQEQSQLQSELLNIESQCIMLSEGI 755
+ N E ++ + HL + Q L+ +L +E + ++ +
Sbjct: 1630 EIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEV 1689
Query: 756 KERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFEKQKT 815
+E + + E E+ K+ + E + + + + + K++ E D +++ E +
Sbjct: 1690 EELRASL-ERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMED- 1747
Query: 816 RLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNELMAKQQQLKD 875
+ + + KK + + E ++K + HL++ ++N QTV +L + + +
Sbjct: 1748 -IVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQ 1806
Query: 876 IRV--------TQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEV--VSIQTSLEQKRLE 925
+ + + ++++++E E+K + + + K ++ V ++ QT ++K +
Sbjct: 1807 LALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNIL 1866
Query: 926 KHNLLLD 932
+ L+D
Sbjct: 1867 RLQDLVD 1873
Score = 77.4 bits (189), Expect = 8e-14
Identities = 143/775 (18%), Positives = 328/775 (42%), Gaps = 93/775 (12%)
Query: 151 RTQFFEEISTSGELIGEYEEKKRKLQKAEEDAQFNFN---------KKKNIAAERRQAKL 201
R + + ++ GE I + K+KL+K + + + N K E+ L
Sbjct: 1197 RKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTL 1256
Query: 202 E------KEEAERYQSLLEELKMNKIQLQLF------QLYHNEKKIHLLNT-------KL 242
E K + E Q L+ EL K +L QL + + L+ ++
Sbjct: 1257 EDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQI 1316
Query: 243 EHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQL---QQTEKELKSVETLLNQKRPQY- 298
E + R L + ++ S + +++ + + +L Q Q+ + EL+ + N + Q+
Sbjct: 1317 EELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376
Query: 299 IKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDAAWRSFEKQIEEEI 358
K + + ++L+ AKK + ++ E+ ++A+ ++ A L+ + + ++E+ +
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLA---QRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433
Query: 359 LHKKRD----IELEASQLD----------RYKELKEQV---RKKVATMTQQLEKLQWEQK 401
+ +R I L+ Q + +Y+E + ++ +K+ +++ +L K++ +
Sbjct: 1434 IDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYE 1493
Query: 402 TDEERLAFEKRRHGEVQGNLKQIKEQIEDHKKRIEKLEEYTKTCMDCLKEKKQQEETLVD 461
+ L KR + +Q + + EQI + K I +LE+ K L +K + +T ++
Sbjct: 1494 ESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQ----LDHEKSELQTSLE 1549
Query: 462 EIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYPDSVFGRLFD 521
E E + +EE ++R +L+ + + ++ ++ E L+ LKR + V
Sbjct: 1550 EAEASLE-----HEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQST 1604
Query: 522 LCHPIHKKYQ-LAVTKVFGRFITAIVVA---SEKVAKDCIRFLKEERAE-PETFLALDYL 576
L I + L + K + + + + + A + +R L+ + +T L LD
Sbjct: 1605 LDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDA 1664
Query: 577 DIKPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCET--MEEARHIALSGPE 634
I+ ++ +L + ++++ + +L+ ++ + E ++ + + L +
Sbjct: 1665 -IRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQ 1723
Query: 635 RQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMKT-LR 693
+ L I G D+ +AR +EK K + D + +ELK T
Sbjct: 1724 NTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDA-AMMAEELKKEQDTSAH 1782
Query: 694 KETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNIESQCIMLSE 753
E K ++ ++ Q RL ++ KK + +L+SE+ + + + +
Sbjct: 1783 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVK 1842
Query: 754 GIKERQRRIKE--FQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKRLEFE 811
G+++ +RR+KE +Q + D+ +NI ++ K Q ++ + + E
Sbjct: 1843 GLRKHERRVKELTYQTEEDR---------------KNILRLQDLVDKLQTKVKAYKRQAE 1887
Query: 812 KQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLK-KAEENCLQTVNE 865
+ + + NV L + +K +++ KE ++ L+ K+ E + ++E
Sbjct: 1888 EAEEQSNVNL----AKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISE 1938
Score = 66.2 bits (160), Expect = 2e-10
Identities = 84/418 (20%), Positives = 182/418 (43%), Gaps = 42/418 (10%)
Query: 684 ELKGLMKTLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSE--- 740
++K L+K+ E ++ ++ + T+ L ++ + + +++K +V QE++ LQ +
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEK-MVTLMQEKNDLQLQVQA 897
Query: 741 ----LLNIESQCIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVE---NIREFE 793
L + E +C L + + + +IKE E+ ED+ EEI E R+ E
Sbjct: 898 EADALADAEERCDQLIKTKIQLEAKIKEVTER---AEDE------EEINAELTAKKRKLE 948
Query: 794 NKHVKRQQEIDQKRLEFEKQKTRLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLK 853
++ + +++ID L K + + + + +K ++ L ETI K +++ L+
Sbjct: 949 DECSELKKDIDDLELTLAKVEKEKHA----TENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004
Query: 854 KAEENCLQTVNELMAKQQQLKDIRVTQNSSAEKVQTQIEEERKKFLAVDREVGKLQKEVV 913
+A + L + K L + + ++ +E+E+K + ++R KL+ ++
Sbjct: 1005 EAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLK 1064
Query: 914 SIQTSLEQKRLEKHNLLLDCKVQDIEIILLSGSLDD--IIEVEMGTEAESTQATIDIYEK 971
Q S +K L K ++ E+ L G ++D + +++ + + QA I+ E
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIE--EL 1122
Query: 972 EEAFEIDYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVR 1031
EE E + +S KA + ++ L + +++ N + + +R
Sbjct: 1123 EEEIEAERAS---RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMR 1179
Query: 1032 DKFQESTDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNS 1089
+EST EA+ R K+ D + E + S+ ++ +KL + S
Sbjct: 1180 RDLEESTLQHEATAAALR----------KKHADSVAELGEQID-SLQRVKQKLEKEKS 1226
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,003,436
Number of Sequences: 37866
Number of extensions: 1906936
Number of successful extensions: 24725
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 320
Number of HSP's successfully gapped in prelim test: 1223
Number of HSP's that attempted gapping in prelim test: 10625
Number of HSP's gapped (non-prelim): 7852
length of query: 1235
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1121
effective length of database: 13,930,794
effective search space: 15616420074
effective search space used: 15616420074
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.