Search of human proteins with 71051596

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|71051596 coiled-coil domain containing 7 [Homo sapiens]
         (486 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|71051596 coiled-coil domain containing 7 [Homo sapiens]            952   0.0  
gi|37059792 coiled-coil domain containing 7 [Homo sapiens]            952   0.0  
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    63   5e-10
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    60   3e-09
gi|148746195 trichohyalin [Homo sapiens]                               58   2e-08
gi|237858621 polyamine modulated factor 1 binding protein 1 isof...    57   5e-08
gi|237858619 polyamine modulated factor 1 binding protein 1 isof...    57   5e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    54   4e-07
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]     54   4e-07
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           53   7e-07
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           53   7e-07
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           53   7e-07
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             53   7e-07
gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]            53   7e-07
gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]            53   7e-07
gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]            53   7e-07
gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens]            53   7e-07
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    52   9e-07
gi|7705415 hook homolog 1 [Homo sapiens]                               52   1e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     52   1e-06
gi|190194355 p90 autoantigen [Homo sapiens]                            52   2e-06
gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]         52   2e-06
gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens]         52   2e-06
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    52   2e-06
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    52   2e-06
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    52   2e-06
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    52   2e-06
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    51   3e-06
gi|87299628 biorientation of chromosomes in cell division 1-like...    51   3e-06
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s...    51   3e-06

>gi|71051596 coiled-coil domain containing 7 [Homo sapiens]
          Length = 486

 Score =  952 bits (2461), Expect = 0.0
 Identities = 486/486 (100%), Positives = 486/486 (100%)

Query: 1   MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGE 60
           MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGE
Sbjct: 1   MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGE 60

Query: 61  SILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEE 120
           SILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEE
Sbjct: 61  SILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEE 120

Query: 121 LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA 180
           LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA
Sbjct: 121 LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA 180

Query: 181 EPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEA 240
           EPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEA
Sbjct: 181 EPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEA 240

Query: 241 LAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLD 300
           LAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLD
Sbjct: 241 LAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLD 300

Query: 301 AEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK 360
           AEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK
Sbjct: 301 AEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK 360

Query: 361 KMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKS 420
           KMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKS
Sbjct: 361 KMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKS 420

Query: 421 EGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSGR 480
           EGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSGR
Sbjct: 421 EGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSGR 480

Query: 481 LIEKRC 486
           LIEKRC
Sbjct: 481 LIEKRC 486


>gi|37059792 coiled-coil domain containing 7 [Homo sapiens]
          Length = 486

 Score =  952 bits (2461), Expect = 0.0
 Identities = 486/486 (100%), Positives = 486/486 (100%)

Query: 1   MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGE 60
           MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGE
Sbjct: 1   MKPVKHLLTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGE 60

Query: 61  SILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEE 120
           SILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEE
Sbjct: 61  SILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEE 120

Query: 121 LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA 180
           LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA
Sbjct: 121 LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA 180

Query: 181 EPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEA 240
           EPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEA
Sbjct: 181 EPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEA 240

Query: 241 LAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLD 300
           LAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLD
Sbjct: 241 LAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLD 300

Query: 301 AEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK 360
           AEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK
Sbjct: 301 AEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK 360

Query: 361 KMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKS 420
           KMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKS
Sbjct: 361 KMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKS 420

Query: 421 EGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSGR 480
           EGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSGR
Sbjct: 421 EGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSGR 480

Query: 481 LIEKRC 486
           LIEKRC
Sbjct: 481 LIEKRC 486


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 96/443 (21%), Positives = 180/443 (40%), Gaps = 49/443 (11%)

Query: 22   TKKGLHNLPLSPEL----KEKHNAKLIHDKIEPMVLRS-PPTGESILRYALPIPSSKTKN 76
            TK  L N  +  EL    K K  A+   D +E  ++        SI  Y   +  ++ KN
Sbjct: 1892 TKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN 1951

Query: 77   LLPEDEMIGKIIKHLKMVVSTLEETYGHC--DQNGEEPFVKHEHEELSLSVGDDMNSFLT 134
             L E EM     K+LK  VS LEE       ++   E  ++ E+ E       +  +   
Sbjct: 1952 ELLESEM-----KNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN--- 2003

Query: 135  YCSQFAAQLEEALKEEQNILESLFK---WFQWQVNQMEEISKDQTLLQAEPPKPDKTVIL 191
                 A +L+E LKE+Q  ++ L K    +Q +++ +E   K    +Q E  K  +    
Sbjct: 2004 --KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKE 2061

Query: 192  NIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEA 251
            N+A+ V           +  Q   +S KV+L  T  +  R  A         K+++ L++
Sbjct: 2062 NLAQAVE--------HRKKAQAELASFKVLLDDTQSEAARVLADNL------KLKKELQS 2107

Query: 252  HSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQ 311
            +       +   +      +       LK  +N    L+    ++V L+    ++Q    
Sbjct: 2108 NKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167

Query: 312  LLSEEKLVLENELQKLKDKEK--TKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFK 369
               +E   L+  L     +    TK  ++      + + +  K + + S+   S E+E +
Sbjct: 2168 KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227

Query: 370  IKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQ 429
            +KED               VL++QL+Q     E+ K  ++   + +++ +S+ +TE  +Q
Sbjct: 2228 LKED------------NCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQ 2275

Query: 430  VGNSQTKVKGEDSKNIPLEKETR 452
                 T ++GE+ + +   +ETR
Sbjct: 2276 QKVCDT-LQGENKELLSQLEETR 2297



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 70/350 (20%), Positives = 147/350 (42%), Gaps = 42/350 (12%)

Query: 127  DDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPD 186
            D+ +S  T  S+   QL   +KE   + E   +  Q ++N  E  ++ Q  L  E     
Sbjct: 733  DNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAE--AERQRRLDYESQTAH 790

Query: 187  KTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEA-LAQKI 245
              ++      + +  + +++K  + Q     V++  S+      +   ++S ++ L  K 
Sbjct: 791  DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE------QSTLIRSLQSQLQNKE 844

Query: 246  EEFLEA-----HSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVN--DQVL 298
             E LE      H + + +++S    Q    +T + + +L   +     L++ +   DQ +
Sbjct: 845  SEVLEGAERVRHISSKVEELSQALSQKELEIT-KMDQLLLEKKRDVETLQQTIEEKDQQV 903

Query: 299  LDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDS 358
             +  +   +   QL +EEK  L  E++ LK++             +  + + ++ K E  
Sbjct: 904  TEISFSMTEKMVQL-NEEKFSLGVEIKTLKEQ-------------LNLLSRAEEAKKEQV 949

Query: 359  EKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFL-NQEKL 417
            E+    E    +K++ D++    ++  E   LQ +     +E E+ K +L   L N+++L
Sbjct: 950  EE--DNEVSSGLKQNYDEMSPAGQISKEE--LQHEFDLLKKENEQRKRKLQAALINRKEL 1005

Query: 418  LKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDK 467
            L+   + E  +        +K E  K IPL +  R  +  D   +  S+K
Sbjct: 1006 LQRVSRLEEEL------ANLKDESKKEIPLSETERGEVEEDKENKEYSEK 1049



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 76/378 (20%), Positives = 147/378 (38%), Gaps = 83/378 (21%)

Query: 142  QLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQ 201
            Q  E + EE    + + +  Q  +   +E  K+   LQ E       + L    I RL +
Sbjct: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEE-------LSLARGTIERLTK 1518

Query: 202  RFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAV--------------KSCEALAQKIEE 247
               ++++++  ++K    V+    + +E R + +               SCE+L   +E 
Sbjct: 1519 SLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEG 1578

Query: 248  FLE--------AHSTDEFKDVSATEPQTAHS-MTNRFNAMLKVFENQANMLERAVNDQVL 298
              E          S    K   +TE Q  H  +   +  +L+ +EN +N  ER    Q +
Sbjct: 1579 LTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERI---QHV 1635

Query: 299  LDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDS 358
            ++A                  +  E Q+L  K ++   N          KK+ + + +++
Sbjct: 1636 VEA------------------VRQEKQELYGKLRSTEAN----------KKETEKQLQEA 1667

Query: 359  EKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQA------------------LQE 400
            E++M   KE   K    + QK+  LE EN  L+ ++  A                   +E
Sbjct: 1668 EQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEE 1727

Query: 401  AEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPL---EKETRKSLVS 457
             E+ K +      + + L SE K   + +V + + +++G  SK   L   EK   ++ V+
Sbjct: 1728 LERVKMEYETLSKKFQSLMSE-KDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVT 1786

Query: 458  DSGGQRTSDKIQEYPQIT 475
            + G Q    + +E   ++
Sbjct: 1787 EEGTQSIPGETEEQDSLS 1804



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 41/156 (26%), Positives = 81/156 (51%), Gaps = 12/156 (7%)

Query: 305 QMQCDFQLLSEEKLVLENELQKLKDKEKTKPTN-NRTKKAVK----TVKKKDKGKSEDSE 359
           Q+Q   + L EE+   +N+++KLK   K K T+ N+  + +K    TV   +    E   
Sbjct: 74  QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLS 133

Query: 360 K--KMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQA-LQEAEKAKHQLNYFLNQEK 416
           K  K S E+E +I++   ++Q+   L      LQ QL QA  ++  ++  ++  F+  ++
Sbjct: 134 KHDKSSTEEEMEIEKIKHKLQEKEEL---ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQ 190

Query: 417 LLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETR 452
            L+ + +  +T+Q   SQT+ + + ++ +  EK+ R
Sbjct: 191 QLQEKEEFISTLQAQLSQTQAE-QAAQQVVREKDAR 225



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 83/390 (21%), Positives = 160/390 (41%), Gaps = 76/390 (19%)

Query: 92   KMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVG-DDMNSFLTYCSQFAAQLEEALKEE 150
            K ++S LEET  H   + +    K E E  SL     D+++ L  C +    LE  ++++
Sbjct: 2287 KELLSQLEETR-HLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQ 2345

Query: 151  Q-NILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNR 209
            + +I  S F +        E++  D    +    +  + + +   +I+ L+   EE    
Sbjct: 2346 EADIQNSKFSY--------EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEE---- 2393

Query: 210  LKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAH 269
                   +++V +++   ++   + +K  E L  + EE            V   E + A 
Sbjct: 2394 -------AIQVAIAEL--RQQHDKEIKELENLLSQEEEE---------NIVLEEENKKAV 2435

Query: 270  SMTNRFNAMLKVFEN----QANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQ 325
              TN+    LK  +     Q   L+  V     L  +  ++  D+Q L E  L +  E  
Sbjct: 2436 DKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKD 2495

Query: 326  KLKDKEKTKPTNNRTKKAVKTVKKK-DKGKSEDSEKKMSPEKEFKIKEDLDQV------- 377
            +L  +   +  NN+ K+ ++ ++   D   SE++  K+  E   + +EDL+QV       
Sbjct: 2496 QLIQEAAAE--NNKLKEEIRGLRSHMDDLNSENA--KLDAEL-IQYREDLNQVITIKDSQ 2550

Query: 378  -------QKVARLEIENKV--LQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKT---- 424
                   Q     E+ENK   L+E+LK++ +  E  +   N    +++ L  E ++    
Sbjct: 2551 QKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVS 2610

Query: 425  -------------ETTMQVGNSQTKVKGED 441
                         E T+ + ++Q KVK E+
Sbjct: 2611 ISQLTRQVTALQEEGTLGLYHAQLKVKEEE 2640



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 67/329 (20%), Positives = 136/329 (41%), Gaps = 33/329 (10%)

Query: 106 DQNGEEPFVKHEHEELSLSVG----DDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWF 161
           DQN   P     H+E  +       +D+   L Y  Q   +L++ ++++           
Sbjct: 23  DQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV--------- 73

Query: 162 QWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNR--LKQRSKSSVK 219
             Q+ Q +E  +++   +A   K  K  +   A++  L +  EE+K +      ++   +
Sbjct: 74  --QLQQKDEALQEER--KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSE 129

Query: 220 VMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAML 279
             LSK  DK +  E ++  E +  K++E  E  ST + +   A   Q A S T      +
Sbjct: 130 EQLSKH-DKSSTEEEME-IEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTE-----M 182

Query: 280 KVFENQANMLERAVNDQVLLDAEYKQMQCDF---QLLSEEKLVLENELQKLKDKEKTKPT 336
           + F      L+        L A+  Q Q +    Q++ E+    E +++  +D+     T
Sbjct: 183 EEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVT 242

Query: 337 NNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQ 396
               +  ++   +  + K E+ E+ +    +     DL Q Q++   E  N++L +QL+Q
Sbjct: 243 QADVETEMQQKLRVLQRKLEEHEESLVGRAQVV---DLLQ-QELTAAEQRNQILSQQLQQ 298

Query: 397 ALQEAEKAKHQLNYFLNQEKLLKSEGKTE 425
              E    ++ +     + K+L  + + E
Sbjct: 299 MEAEHNTLRNTVETEREESKILLEKMELE 327



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 61/332 (18%), Positives = 126/332 (37%), Gaps = 42/332 (12%)

Query: 141  AQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLV 200
            A+LEE LKE +   E L + F     + +++SK+   L+           ++I+++ R V
Sbjct: 2570 AKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLK-----------VSISQLTRQV 2618

Query: 201  QRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDV 260
               +E         + ++ +  ++   KE     + +  + +QK    LE    +E   V
Sbjct: 2619 TALQE---------EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELE----EELVCV 2665

Query: 261  SATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVL 320
                 +    + ++    LK   + A ++    N+    +    ++  D   + ++ L++
Sbjct: 2666 QKEAAKKVGEIEDKLKKELKHLHHDAGIMR---NETETAEERVAELARDLVEMEQKLLMV 2722

Query: 321  ENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKV 380
              E     +K  T    +  +        +D    E  E K   +   K   +L Q+++ 
Sbjct: 2723 TKE-----NKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLK---ELAQLKEQ 2774

Query: 381  ARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGE 440
              L  E   L  +   ++   E+        LNQ+ L K E     + Q+ +S  +V+  
Sbjct: 2775 GLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSF 2834

Query: 441  DSKNIPLE-------KETRKSLVSDSGGQRTS 465
                  L+        E  K   S+ G QR++
Sbjct: 2835 SKAMASLQNERDHLWNELEKFRKSEEGKQRSA 2866


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 113/451 (25%), Positives = 185/451 (41%), Gaps = 73/451 (16%)

Query: 26  LHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGESILRYALPIPSSKTKNLLPEDEMIG 85
           +H+L    E KEK N+ L                E   R+     S+KTK L    EM  
Sbjct: 343 VHHLESLLEQKEKENSMLRE--------------EMHRRFENAPDSAKTKALQTVIEMKD 388

Query: 86  KIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDDMNSFLTYCSQFAAQLEE 145
             I  ++  +  LEE       NG     + E E   + V           S+F     E
Sbjct: 389 SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSH-------SKFMKNKVE 441

Query: 146 ALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEE 205
            LKEE +  E+     QW     EE+ K    LQAE  +  + +     E++ L  + E 
Sbjct: 442 QLKEELSSKEA-----QW-----EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLET 491

Query: 206 LKNRLKQRSKSSVKVMLSKTMDKENRPEAVKS-CEALAQKIE--EFLEAHSTDEFKDVSA 262
           L N+    SK  ++V+      KE R   +++  +AL  ++E  E +    T + +D+ A
Sbjct: 492 LTNQFSD-SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM-A 549

Query: 263 TEPQTAHSMTNRFNAMLKVFENQANMLERAV-NDQVLLDAEYKQM--------------- 306
            E  T     +    ML V E + N+L++ + N Q  L  + KQM               
Sbjct: 550 EEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 609

Query: 307 QCDFQLLSEEKLVLENE--LQKLK------DKEKTKPTNNRTKKAVKTVKKKD---KGKS 355
             D  L + E+ + E E  +++LK      ++EK +  +N  KK +K +K+K    +G  
Sbjct: 610 NTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN-YKKDLKDLKEKVSLLQGDL 668

Query: 356 EDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQE 415
            + E  +   KE         ++K +RL    K L+  L+Q  +E  K + QL      E
Sbjct: 669 SEKEASLLDLKEHASSLASSGLKKDSRL----KTLEIALEQKKEECLKMESQLK--KAHE 722

Query: 416 KLLKSEGKTETTMQVGNSQ---TKVKGEDSK 443
             L++    E + ++ + +   T+ K E SK
Sbjct: 723 AALEARASPEMSDRIQHLEREITRYKDESSK 753



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 74/366 (20%), Positives = 154/366 (42%), Gaps = 54/366 (14%)

Query: 133 LTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILN 192
           LT   Q AA L+  +   +  LE        +  Q++++++++     E       + + 
Sbjct: 510 LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569

Query: 193 IAEIVRLVQRFEELKNRLKQRSK--SSVKVML-SKTMDKENRPEAVKSCE-ALAQK---I 245
             ++  L ++ E L+ +L+ + K  SS+K  + S   D  N   A+ + E ALA+K   I
Sbjct: 570 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629

Query: 246 EEFLEAHSTDE-------------FKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERA 292
           E   E    DE              KD+          ++ +  ++L + E+ +++    
Sbjct: 630 ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 689

Query: 293 VNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKD-------------------KEKT 333
           +      D+  K ++   +   EE L +E++L+K  +                   +E T
Sbjct: 690 LKK----DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREIT 745

Query: 334 KPTNNRTKKAVKT-----VKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENK 388
           +  +  +K   +      + K+ + +  D +KK++ E E ++K   DQ +KVA L+ + +
Sbjct: 746 RYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA-ELERQVK---DQNKKVANLKHKEQ 801

Query: 389 VLQEQLKQALQEAEKAKHQLNYFLN--QEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIP 446
           V +++  Q L+EA + +  LN      Q+ L K + + E   +      ++  E    + 
Sbjct: 802 VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLA 861

Query: 447 LEKETR 452
            E+  R
Sbjct: 862 QEESAR 867


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 71/353 (20%), Positives = 149/353 (42%), Gaps = 31/353 (8%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPP-KPDKTVILNIAEIVRLVQR 202
            EE     Q   E   + F WQ    E+  + +  L A PP +  +   L   E  +  QR
Sbjct: 750  EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQR 809

Query: 203  F----EELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFK 258
            F    EE + R +QR +   ++   +  ++  R E  +  +     ++E  E   + E +
Sbjct: 810  FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869

Query: 259  DVSATEPQTAHSMTNRFNAML-------------KVFENQANMLERAVNDQVLLDAEYKQ 305
                   Q       R + +              ++ + +   L+R   ++     + +Q
Sbjct: 870  RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929

Query: 306  MQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPE 365
             + + QL  EE+ +L  E +K + +E+ +    + +K  K  +K+++   E+ EK+   E
Sbjct: 930  YREEEQLQQEEEQLLREEREKRRRQERER----QYRKDKKLQQKEEQLLGEEPEKRRRQE 985

Query: 366  KEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTE 425
            +E K +E+ +  Q     E E  + +E+ K+  QE E+   + +    +E+ L  E + +
Sbjct: 986  REKKYREEEELQQ-----EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040

Query: 426  TTMQVGNSQ----TKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQI 474
              +Q    Q     +++ E+ + +  E+ETR+    +   ++  +  QE  Q+
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 56/327 (17%), Positives = 144/327 (44%), Gaps = 33/327 (10%)

Query: 171 ISKDQTLLQAEPPKPDKTVI--------LNIAEIVRLVQRFEELKNRLKQRSKSSVKVML 222
           + K++  LQ E P+  + +         L   E+ R  Q  E+ + RL++  +   K   
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312

Query: 223 SKTMDKENRPEAVKSCEALAQKIEEFLEAHSTD------------EFKDVSATEPQTAHS 270
            +   +E R E  +  E   ++ E+ L     +            E ++      Q    
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372

Query: 271 MTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDK 330
              +     ++   Q    E+ +  +  L  E +Q++ + QL  E++L  E +L++ +++
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLRREQEE 431

Query: 331 EKTKPTNNRTKKAVKTVKKKDKGKS-----EDSEKKMSPEKEFKIKEDLDQVQKVARLEI 385
           E+ +  + + ++  +  +++++ +      E++E+     ++ ++K D ++ ++   L++
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491

Query: 386 ENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVK--GEDSK 443
           E +  +EQ ++  Q+  + + +      +E+ LK + + E   Q   S+ +++   E+ +
Sbjct: 492 EEEERREQQERREQQLRREQEE-----RREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546

Query: 444 NIPLEKETRKSLVSDSGGQRTSDKIQE 470
              L++E  K L  +   QR   + +E
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEE 573



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 36/143 (25%), Positives = 72/143 (50%), Gaps = 12/143 (8%)

Query: 289  LERAVNDQVLLDAEYKQMQCDFQ-----LLSEEKLVLENELQKLKDKEKTKPTNNRTKKA 343
            LER   ++  L  E +Q Q   Q     +L EE+L  E E Q+L+ +E+ +    R ++ 
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF--REEEQ 1778

Query: 344  VKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVAR-----LEIENKVLQEQLKQAL 398
            ++  +++ + +S++S++K   E++ + + +  Q++   R      E E   L+EQ ++  
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLR 1838

Query: 399  QEAEKAKHQLNYFLNQEKLLKSE 421
            QE ++       F  QEK  + E
Sbjct: 1839 QERDRQYRAEEQFATQEKSRREE 1861



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 64/351 (18%), Positives = 155/351 (44%), Gaps = 21/351 (5%)

Query: 138  QFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIV 197
            Q   + E+ L+EE+       +  Q++ ++  +  K++ LL  EP K  +          
Sbjct: 935  QLQQEEEQLLREEREKRRRQERERQYRKDKKLQ-QKEEQLLGEEPEKRRRQEREKKYREE 993

Query: 198  RLVQRFEE--LKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTD 255
              +Q+ EE  L+   ++R +   +    K  + +   E +   E   ++++E    +  +
Sbjct: 994  EELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053

Query: 256  EFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQ--MQCDFQLL 313
            E       +       T R   + + +  +  + +    +Q+L +   K+   + + Q  
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYRKEEELQQE--EEQLLREEPEKRRRQERERQCR 1111

Query: 314  SEEKLVLENE--LQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPE--KEFK 369
             EE+L  E E  L++ ++K + +    + ++  +  +++++   E+ EK+   E  ++++
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171

Query: 370  IKEDLDQVQKVARLEIENKVLQEQLKQALQEAE--KAKHQLNY-FLNQEKLLKSEGKTET 426
             +E+L Q ++    E + K  QE+ +Q  +E E  + K +  Y   +Q   LK + + E 
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231

Query: 427  TMQVGNSQTKVKGEDSKNIP-------LEKETRKSLVSDSGGQRTSDKIQE 470
               V +++   KG +++           ++++++ L    G Q+  D+ QE
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE 1282



 Score = 36.2 bits (82), Expect = 0.069
 Identities = 52/297 (17%), Positives = 127/297 (42%), Gaps = 32/297 (10%)

Query: 144 EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRF 203
           E+ L+ EQ +        + Q+ + +++ ++Q L + +  +  +          RL +  
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451

Query: 204 EELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSAT 263
           EE ++ LK+  ++       +  ++E R + +K  +   ++ E +L+    +  +     
Sbjct: 452 EERRDWLKREEET-------ERHEQERRKQQLKRDQE-EERRERWLKLEEEERREQQERR 503

Query: 264 EPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENE 323
           E Q       R    LK  E +  + +R  ++Q L   + ++ +   +   E++L  E  
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563

Query: 324 LQKLKDKEKT------KPTNNRTKKAVKT---------VKKKDKGKSEDSE------KKM 362
            Q+LK +++       K    R ++ +K          +K+++  + E  E      K+ 
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623

Query: 363 SPEKEFK---IKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEK 416
            PE+E +   +K +  + ++  +L  E +  +EQ  +  +E E+ + +L     +E+
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 39/198 (19%), Positives = 91/198 (45%), Gaps = 26/198 (13%)

Query: 301 AEYKQMQC----DFQLLSEEKLVLENELQKLKDK---EKTKPTNNRTKKAVKTVKKKDKG 353
           AE +Q+Q     + +   +E+ +   EL +L+ K   EK +    R  +  +  ++K+  
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWR 247

Query: 354 KSED----SEKKM---SPEKEFKIKEDLDQVQKVARLEI----------ENKVLQEQLKQ 396
           K E      E+K+    P+++ +++E+ +Q++K+ R E+          + ++ +EQ  +
Sbjct: 248 KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLR 307

Query: 397 ALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSLV 456
             QE E+ + Q      QE+  + E + E   Q+   Q + + +  +    E+   + L 
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERRE--QQLRREQEERREQQLRREQEEERREQQLR 365

Query: 457 SDSGGQRTSDKIQEYPQI 474
            +   +R   +++   Q+
Sbjct: 366 REQEEERREQQLRREQQL 383



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 66/336 (19%), Positives = 146/336 (43%), Gaps = 51/336 (15%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRF 203
            E+ L+EE+   +   +  + Q  + EE+ +++  L  E P+  +       E+ R  +  
Sbjct: 1121 EQLLREERE--KRRRQELERQYREEEEVQQEEEQLLREEPEKRRR-----QELERQYREE 1173

Query: 204  EELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVS-A 262
            EEL+   +Q  +        +   ++ R    +  E L Q+ +        D+  D+   
Sbjct: 1174 EELQQEEEQLLREE------QEKRRQERERQYREEEEL-QRQKRKQRYRDEDQRSDLKWQ 1226

Query: 263  TEPQTAHSMTNRFNAMLKVF-ENQANMLERAVNDQVLLDAEYKQMQCDFQLL--SEEKLV 319
             EP+  +++ +      KV+ + + N   R + D  L D   +Q Q D Q L   +++  
Sbjct: 1227 WEPEKENAVRDN-----KVYCKGRENEQFRQLEDSQLRD---RQSQQDLQHLLGEQQERD 1278

Query: 320  LENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKE-----------F 368
             E E ++ + +++  P   + ++  +   K+   KS++ ++ +  E+E           F
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338

Query: 369  KIKEDLDQ---VQKVARLEIENKVLQEQL------KQALQEAEKAKHQ--LNYFLNQEKL 417
            + +E L Q    Q + R E + K  +E+L      ++ L+E ++ + Q     FL +E+ 
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398

Query: 418  LKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
            L+ +   E   Q+   + +   E+ + +  ++  RK
Sbjct: 1399 LRCQ---EREQQLRQDRDRKFREEEQQLSRQERDRK 1431



 Score = 34.7 bits (78), Expect = 0.20
 Identities = 31/141 (21%), Positives = 66/141 (46%), Gaps = 7/141 (4%)

Query: 283  ENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKK 342
            E +   L R   D+   + E +  +   + L EE+ +   E ++   KE+ +      ++
Sbjct: 1347 EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQ 1406

Query: 343  AVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQE--QLKQALQE 400
             ++  + +D+   E+ ++    E++ K +E   + Q+V R E E K L+E  QL+Q    
Sbjct: 1407 QLR--QDRDRKFREEEQQLSRQERDRKFRE---EEQQVRRQERERKFLEEEQQLRQERHR 1461

Query: 401  AEKAKHQLNYFLNQEKLLKSE 421
              + + QL     +++L + E
Sbjct: 1462 KFREEEQLLQEREEQQLHRQE 1482



 Score = 34.3 bits (77), Expect = 0.26
 Identities = 55/329 (16%), Positives = 133/329 (40%), Gaps = 48/329 (14%)

Query: 106 DQNGEEPFVKHEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQV 165
           ++ G+    K + +E  L+ G++ +       Q   +  +  + ++ +     +W + + 
Sbjct: 131 EEPGQRRRQKRQEQERELAEGEEQSE-----KQERLEQRDRQRRDEELWRQRQEWQEREE 185

Query: 166 NQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKT 225
            + EE              PD+   L   E++ L ++  E K + ++  +  V     + 
Sbjct: 186 RRAEEEQLQSCKGHETEEFPDEEQ-LRRRELLELRRKGREEKQQQRRERQDRV---FQEE 241

Query: 226 MDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQ 285
            +KE R       E + +K EE L+       +++   E Q            L+  E Q
Sbjct: 242 EEKEWRKR-----ETVLRKEEEKLQEEEPQRQRELQEEEEQ------------LRKLERQ 284

Query: 286 ANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVK 345
               ER   +Q                  +++L  E +L++ +++E+ +    R ++   
Sbjct: 285 ELRRERQEEEQ-----------------QQQRLRREQQLRRKQEEERREQQEERREQ--- 324

Query: 346 TVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAK 405
             +++ + + E  E+++  E+E + ++ L + Q+  R E + +  QE+ ++  Q   + +
Sbjct: 325 --QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 406 HQLNYFLNQEKLLKSEGKTETTMQVGNSQ 434
            +    L +E+ L+ E +     Q+   Q
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQ 411



 Score = 32.7 bits (73), Expect = 0.76
 Identities = 62/336 (18%), Positives = 150/336 (44%), Gaps = 20/336 (5%)

Query: 144 EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRF 203
           +E  +E+Q   E   +  Q    + EE  ++Q L + +  +  +  +    ++ R  Q  
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390

Query: 204 EELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSAT 263
            E + R +Q+ +   ++   + + +E +   ++  + L ++ EE  E H  ++  +    
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQ---LRREQQLRREQEE--ERH--EQKHEQERR 443

Query: 264 EPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVL-EN 322
           E +       R + + +  E + +  ER    Q+  D E ++ +   +L  EE+    E 
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERR-KQQLKRDQEEERRERWLKLEEEERREQQER 502

Query: 323 ELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKI-----KEDLDQV 377
             Q+L+ +E+ +    R K+  +  + + + +SE   ++   E+  ++     ++ L+Q 
Sbjct: 503 REQQLR-REQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561

Query: 378 QKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKV 437
           ++  RL+ E +  ++QL +  +E  + + +       E+ LK E + E   Q    + ++
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE-EVERLEQEERREQRL 620

Query: 438 KGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQ 473
           K E+    P E+  ++ L S+   +R   +++   Q
Sbjct: 621 KREE----PEEERRQQLLKSEEQEERRQQQLRREQQ 652


>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
           b [Homo sapiens]
          Length = 882

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 84/387 (21%), Positives = 161/387 (41%), Gaps = 31/387 (8%)

Query: 80  EDEMIGKIIKHLKMVVSTLEETYGHCDQNGE-EPFVKHEHEELSLSVGDDMNSFLTYCSQ 138
           E E I KI+KHL+      E+    C    E +  VK    EL  +V +   + +    +
Sbjct: 155 ECEDIKKILKHLQ------EQKDSQCLHVEEYQNLVKDLRVELE-AVSEQKRNIMKDMMK 207

Query: 139 FAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVR 198
               L    +E    +E   K       +++E+  + T  Q    K DK +      +  
Sbjct: 208 LELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQE 267

Query: 199 LVQRFEELKNRLKQRSKSSVKVMLSKT----------MDKENRPEAVKSCEALAQKIEEF 248
           L ++  +++N L ++ K   K     T           DK    E  K+ +A  QK++  
Sbjct: 268 LEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNS 326

Query: 249 LEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQC 308
           LE     E         Q A        A   + + Q  + +  + D+   D   +++Q 
Sbjct: 327 LEEAKQQE----RLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT-IQELQR 381

Query: 309 DFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEF 368
           + Q+L +E  + E E  +  ++++ +  +    +A++ ++  DK K +   +K   E++ 
Sbjct: 382 ELQMLQKESSMAEKE--QTSNRKRVEELSLELSEALRKLENSDKEKRQ--LQKTVAEQDM 437

Query: 369 KIKEDLDQVQKVARLEIENKV-LQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETT 427
           K+ + LD+++   R +   K  L+E L++A +  E  + QL      EKL+  EG+ E  
Sbjct: 438 KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLM--EGELEAL 495

Query: 428 MQVGNSQTKVKGEDSKNIPLEKETRKS 454
            Q    + K   E+S+ +  E E  ++
Sbjct: 496 RQEFKKKDKTLKENSRKLEEENENLRA 522



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 63/311 (20%), Positives = 126/311 (40%), Gaps = 42/311 (13%)

Query: 136 CSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKT------- 188
           C + AA     L++ Q  L+      + + + ++E+ ++  +LQ E    +K        
Sbjct: 344 CKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKR 403

Query: 189 ---VILNIAEIVRLVQRFEELKNRLKQ--------------------RSKSSVKVMLSKT 225
              + L ++E +R ++  ++ K +L++                    R + S+K  L + 
Sbjct: 404 VEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEED 463

Query: 226 MDK-----ENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLK 280
           + +     E++ E +K  +   + +E  LEA    EFK    T  + +  +      +  
Sbjct: 464 LQEATKLLEDKREQLKKSKEHEKLMEGELEA-LRQEFKKKDKTLKENSRKLEEENENLRA 522

Query: 281 VFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRT 340
             +  +  LE ++N         + +  +  L  E  + L+ +L K   KEK       T
Sbjct: 523 ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTIT 582

Query: 341 KKAVKTVKKKDKGKSED----SEKKMSPEKEFK-IKEDLDQVQ-KVARLEIENKVLQEQL 394
           K+A   + +K     +D     EK      E K +++ L Q Q K A+LE E    +E++
Sbjct: 583 KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM 642

Query: 395 KQALQEAEKAK 405
           K+   E  K +
Sbjct: 643 KKLNTELRKLR 653



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 87/409 (21%), Positives = 169/409 (41%), Gaps = 54/409 (13%)

Query: 63  LRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEE-PFVKHEHEEL 121
           LR  L   S + +N++ +   +   +  L+      EET  H ++  ++   ++   +EL
Sbjct: 187 LRVELEAVSEQKRNIMKDMMKLELDLHGLR------EETSAHIERKDKDITILQCRLQEL 240

Query: 122 SLSVGDDM------NSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQ 175
            L   +        + FL    +   +LE+ L + QN L    K  + Q     E+  + 
Sbjct: 241 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATEL--EM 298

Query: 176 TLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAV 235
           T+ +A+  K  +      AE   L    ++LKN L++  +            KE    A 
Sbjct: 299 TVKEAKQDKSKE------AECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAG 352

Query: 236 KSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAML--------KVFENQAN 287
              E   +K+++ L     D+ K  +  E Q    M  + ++M         K  E  + 
Sbjct: 353 CHLEDTQRKLQKGL---LLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSL 409

Query: 288 MLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPT-----NNRTKK 342
            L  A+      D E +Q+Q   + ++E+ + + + L ++K + + + +         ++
Sbjct: 410 ELSEALRKLENSDKEKRQLQ---KTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQE 466

Query: 343 AVKTV--KKKDKGKSEDSEKKMSPE-----KEFKIKEDLDQVQKVARLEIENKVLQEQLK 395
           A K +  K++   KS++ EK M  E     +EFK K+D    +   +LE EN+ L+ +L+
Sbjct: 467 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFK-KKDKTLKENSRKLEEENENLRAELQ 525

Query: 396 QALQEAEKAKHQLN------YFLNQEKLLKSEGKTETTMQVGNSQTKVK 438
               + E + ++ N        LN+E  L+ E       Q+  +  K K
Sbjct: 526 CCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEK 574



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 62/297 (20%), Positives = 123/297 (41%), Gaps = 53/297 (17%)

Query: 204 EELKNRLK-------QRSKSSVKVML---SKTMDKENRPEAVKSCEALAQKIEEFLEAHS 253
           +EL+N+L        +R K+ +K+     S T      P + + CE + + ++   E   
Sbjct: 112 QELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKD 171

Query: 254 T-----DEF----KDVSATEPQTAHSMTNRFNAMLKVF-------ENQANMLERAVNDQV 297
           +     +E+    KD+       +    N    M+K+        E  +  +ER   D  
Sbjct: 172 SQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDIT 231

Query: 298 LLDAEYKQMQCDFQ-----LLSEEKLVLENE--LQKLKDKEKTKPTNNRTKKAVK----- 345
           +L    +++Q +F       L ++K + E +  LQ+L +K+ T+  N+  KK  +     
Sbjct: 232 ILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQEL-EKKLTQVQNSLLKKEKELEKQQ 290

Query: 346 --------TVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKV-LQEQLKQ 396
                   TVK+  + KS+++E K    +  K+K  L++ ++  RL  +     +E+   
Sbjct: 291 CMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAAL 350

Query: 397 ALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
           A    E  + +L     Q+ LL  + K +T  ++      ++ E S     +   RK
Sbjct: 351 AGCHLEDTQRKL-----QKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRK 402


>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
           a [Homo sapiens]
          Length = 1007

 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 84/387 (21%), Positives = 161/387 (41%), Gaps = 31/387 (8%)

Query: 80  EDEMIGKIIKHLKMVVSTLEETYGHCDQNGE-EPFVKHEHEELSLSVGDDMNSFLTYCSQ 138
           E E I KI+KHL+      E+    C    E +  VK    EL  +V +   + +    +
Sbjct: 300 ECEDIKKILKHLQ------EQKDSQCLHVEEYQNLVKDLRVELE-AVSEQKRNIMKDMMK 352

Query: 139 FAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVR 198
               L    +E    +E   K       +++E+  + T  Q    K DK +      +  
Sbjct: 353 LELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQE 412

Query: 199 LVQRFEELKNRLKQRSKSSVKVMLSKT----------MDKENRPEAVKSCEALAQKIEEF 248
           L ++  +++N L ++ K   K     T           DK    E  K+ +A  QK++  
Sbjct: 413 LEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAEC-KALQAEVQKLKNS 471

Query: 249 LEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQC 308
           LE     E         Q A        A   + + Q  + +  + D+   D   +++Q 
Sbjct: 472 LEEAKQQE----RLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQKADT-IQELQR 526

Query: 309 DFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEF 368
           + Q+L +E  + E E  +  ++++ +  +    +A++ ++  DK K +   +K   E++ 
Sbjct: 527 ELQMLQKESSMAEKE--QTSNRKRVEELSLELSEALRKLENSDKEKRQ--LQKTVAEQDM 582

Query: 369 KIKEDLDQVQKVARLEIENKV-LQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETT 427
           K+ + LD+++   R +   K  L+E L++A +  E  + QL      EKL+  EG+ E  
Sbjct: 583 KMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLM--EGELEAL 640

Query: 428 MQVGNSQTKVKGEDSKNIPLEKETRKS 454
            Q    + K   E+S+ +  E E  ++
Sbjct: 641 RQEFKKKDKTLKENSRKLEEENENLRA 667



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 63/311 (20%), Positives = 126/311 (40%), Gaps = 42/311 (13%)

Query: 136 CSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKT------- 188
           C + AA     L++ Q  L+      + + + ++E+ ++  +LQ E    +K        
Sbjct: 489 CKEEAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKR 548

Query: 189 ---VILNIAEIVRLVQRFEELKNRLKQ--------------------RSKSSVKVMLSKT 225
              + L ++E +R ++  ++ K +L++                    R + S+K  L + 
Sbjct: 549 VEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEED 608

Query: 226 MDK-----ENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLK 280
           + +     E++ E +K  +   + +E  LEA    EFK    T  + +  +      +  
Sbjct: 609 LQEATKLLEDKREQLKKSKEHEKLMEGELEA-LRQEFKKKDKTLKENSRKLEEENENLRA 667

Query: 281 VFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRT 340
             +  +  LE ++N         + +  +  L  E  + L+ +L K   KEK       T
Sbjct: 668 ELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEKHYLQTTIT 727

Query: 341 KKAVKTVKKKDKGKSED----SEKKMSPEKEFK-IKEDLDQVQ-KVARLEIENKVLQEQL 394
           K+A   + +K     +D     EK      E K +++ L Q Q K A+LE E    +E++
Sbjct: 728 KEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERM 787

Query: 395 KQALQEAEKAK 405
           K+   E  K +
Sbjct: 788 KKLNTELRKLR 798



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 87/409 (21%), Positives = 169/409 (41%), Gaps = 54/409 (13%)

Query: 63  LRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEE-PFVKHEHEEL 121
           LR  L   S + +N++ +   +   +  L+      EET  H ++  ++   ++   +EL
Sbjct: 332 LRVELEAVSEQKRNIMKDMMKLELDLHGLR------EETSAHIERKDKDITILQCRLQEL 385

Query: 122 SLSVGDDM------NSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQ 175
            L   +        + FL    +   +LE+ L + QN L    K  + Q     E+  + 
Sbjct: 386 QLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATEL--EM 443

Query: 176 TLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAV 235
           T+ +A+  K  +      AE   L    ++LKN L++  +            KE    A 
Sbjct: 444 TVKEAKQDKSKE------AECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAG 497

Query: 236 KSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAML--------KVFENQAN 287
              E   +K+++ L     D+ K  +  E Q    M  + ++M         K  E  + 
Sbjct: 498 CHLEDTQRKLQKGL---LLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSL 554

Query: 288 MLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPT-----NNRTKK 342
            L  A+      D E +Q+Q   + ++E+ + + + L ++K + + + +         ++
Sbjct: 555 ELSEALRKLENSDKEKRQLQ---KTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQE 611

Query: 343 AVKTV--KKKDKGKSEDSEKKMSPE-----KEFKIKEDLDQVQKVARLEIENKVLQEQLK 395
           A K +  K++   KS++ EK M  E     +EFK K+D    +   +LE EN+ L+ +L+
Sbjct: 612 ATKLLEDKREQLKKSKEHEKLMEGELEALRQEFK-KKDKTLKENSRKLEEENENLRAELQ 670

Query: 396 QALQEAEKAKHQLN------YFLNQEKLLKSEGKTETTMQVGNSQTKVK 438
               + E + ++ N        LN+E  L+ E       Q+  +  K K
Sbjct: 671 CCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMSLQAQLDKALQKEK 719



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 62/297 (20%), Positives = 123/297 (41%), Gaps = 53/297 (17%)

Query: 204 EELKNRLK-------QRSKSSVKVML---SKTMDKENRPEAVKSCEALAQKIEEFLEAHS 253
           +EL+N+L        +R K+ +K+     S T      P + + CE + + ++   E   
Sbjct: 257 QELRNKLACSNALVLEREKALIKLQADFASCTATHRYPPSSSEECEDIKKILKHLQEQKD 316

Query: 254 T-----DEF----KDVSATEPQTAHSMTNRFNAMLKVF-------ENQANMLERAVNDQV 297
           +     +E+    KD+       +    N    M+K+        E  +  +ER   D  
Sbjct: 317 SQCLHVEEYQNLVKDLRVELEAVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDIT 376

Query: 298 LLDAEYKQMQCDFQ-----LLSEEKLVLENE--LQKLKDKEKTKPTNNRTKKAVK----- 345
           +L    +++Q +F       L ++K + E +  LQ+L +K+ T+  N+  KK  +     
Sbjct: 377 ILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQEL-EKKLTQVQNSLLKKEKELEKQQ 435

Query: 346 --------TVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKV-LQEQLKQ 396
                   TVK+  + KS+++E K    +  K+K  L++ ++  RL  +     +E+   
Sbjct: 436 CMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAAL 495

Query: 397 ALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
           A    E  + +L     Q+ LL  + K +T  ++      ++ E S     +   RK
Sbjct: 496 AGCHLEDTQRKL-----QKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRK 547


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 71/381 (18%), Positives = 157/381 (41%), Gaps = 21/381 (5%)

Query: 78  LPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDDMNSFLTYCS 137
           + E+E I +  K ++    T+ E      Q  EE   + E +E       +    L    
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKM-QKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504

Query: 138 QFAAQLEEALKEEQNILESLFKWFQ----WQVNQMEEISKDQTLLQAEPPKPDKTVILNI 193
           +   Q E+  ++E+ I +    W Q    W+  +M E  +DQ   Q E  +  +  + + 
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE-QEDQMWEQEEKMRDQEQKMWDQ 563

Query: 194 AEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHS 253
            E +    + +E K   ++      + M  +        E ++  E   Q+ EE ++   
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623

Query: 254 TDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVN--DQVLLDAEYKQMQCDFQ 311
              ++     + Q             K++E +  M E+     +Q  L  E K+   + +
Sbjct: 624 EKMWEQEEKMQEQEE-----------KMWEQEEKMWEQEEKMWEQQRLP-EQKEKLWEHE 671

Query: 312 LLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIK 371
            + E++ + E E +  + ++  K T  + KK     K +++    + EKKM  E+E   +
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731

Query: 372 EDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVG 431
           ++    ++  +++ + + + EQ ++  ++ EK   Q      +EKL + E K +   ++ 
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE-KMQEQEKIW 790

Query: 432 NSQTKVKGEDSKNIPLEKETR 452
             + K++ ++ K    E++ R
Sbjct: 791 EQEEKMRDQEEKMRGQEEKMR 811



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/336 (17%), Positives = 149/336 (44%), Gaps = 31/336 (9%)

Query: 141 AQLEEALKEEQNILE-SLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRL 199
           ++++  +KE +  LE + F   Q Q N ++E    Q   + E  + +K +     ++ R 
Sbjct: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ---EEELREQEKKIRKQEEKMWRQ 298

Query: 200 VQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKD 259
            +R  E + +++++ +   +    K + ++ +    +  E   QK     E    ++ + 
Sbjct: 299 EERLREQEGKMREQEEKMWRQ--EKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356

Query: 260 VSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLV 319
           +   E +        +    +++E +  M E+   +Q + D E +  + D +L  +E+ +
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQ---EQKMRDQEERMWEQDERLREKEERM 413

Query: 320 LENE-----LQKLKDKEKT----KPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKI 370
            E E     ++K+++++K     K T ++ +K  +  + +++ K    E++   E+E K+
Sbjct: 414 REQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKM 473

Query: 371 KEDLDQVQKVARLE-------------IENKVLQEQLKQALQEAEKAKHQLNYFLNQEKL 417
           ++  + + +    E              E + +QEQ ++  ++ EK + Q   +  ++K+
Sbjct: 474 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533

Query: 418 LKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
            + E   E   Q+   + K++ ++ K    E+   K
Sbjct: 534 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 88/410 (21%), Positives = 171/410 (41%), Gaps = 67/410 (16%)

Query: 43   LIHDKIEPMVLRSPPTGESILRYALPIPSSKTKNLLPEDEMIGKIIKHLKMVVSTLEETY 102
            +I  ++    L +P + E +      + S  ++ L  E E + K ++     + TL+E  
Sbjct: 1311 IISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENN 1370

Query: 103  GHCDQN--GEEPFVKHEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKW 160
                 +        + EHE+    +                   + LKE+Q++L+ L K 
Sbjct: 1371 HRLSDSIAATSELERKEHEQTDSEI-------------------KQLKEKQDVLQKLLK- 1410

Query: 161  FQWQVNQMEEISKDQTLLQAE--PPKPDKTVILNIAEIVRLVQRFEELK---NRLKQRSK 215
               + + + +   DQ L   E    K ++  +L  A +  L +R   L+    +LK  ++
Sbjct: 1411 ---EKDLLIKAKSDQLLSSNENFTNKVNENELLRQA-VTNLKERILILEMDIGKLKGENE 1466

Query: 216  SSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDE----FKDVSATEPQTAHSM 271
              V+    K  + +   E       + ++ E   E HS  E    F+ +   + Q     
Sbjct: 1467 KIVETYRGKETEYQALQETNMKFSMMLREKE--FECHSMKEKALAFEQLLKEKEQGKTGE 1524

Query: 272  TNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKE 331
             N+    +K  + +  + ++   DQV+L  + KQM         E   L+NE+Q+L+DKE
Sbjct: 1525 LNQLLNAVKSMQEKTVVFQQE-RDQVMLALKQKQM---------ENTALQNEVQRLRDKE 1574

Query: 332  KTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQ 391
                         ++ ++ ++ ++   E + S  +E    ED     + A+L  +  VL+
Sbjct: 1575 ------------FRSNQELERLRNHLLESEDSYTREALAAED-----REAKLRKKVTVLE 1617

Query: 392  EQLKQALQEAEKAKHQLNYFLN--QEKL-LKSEGKTETTMQVGNSQTKVK 438
            E+L  +    E A HQ +  +   QE+L + S+ + ET +Q+  SQ +VK
Sbjct: 1618 EKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVK 1667



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 66/311 (21%), Positives = 131/311 (42%), Gaps = 68/311 (21%)

Query: 151 QNILESLFKWFQWQVNQMEEISKDQ----TLLQAEPPKPDKTVILNIAEIVRLVQRFEEL 206
           QNI++ L      + N+ +EI   Q     L  A   K  +    +  E+    +R EEL
Sbjct: 215 QNIIKEL------KQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL 268

Query: 207 KNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQ 266
           +N L+Q     ++  LSK  + +   + ++  +  + K  E LE    D+ KD++     
Sbjct: 269 ENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLE----DKIKDIN----- 319

Query: 267 TAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQK 326
                                 L  A ND+ +L  E +Q+  + + + EE   L+ E  K
Sbjct: 320 --------------------KKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSK 359

Query: 327 LKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDL----DQVQKVAR 382
           L+             K   T+ +K++  ++ +    S E+ F++++ L    +++ +++ 
Sbjct: 360 LQPS---------AVKQSDTMTEKERILAQSA----SVEEVFRLQQALSDAENEIMRLSS 406

Query: 383 LEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTM---QVGNSQTKVKG 439
           L  +N + ++ LK  ++            L +EK L S+ K E  M   ++ N    +K 
Sbjct: 407 LNQDNSLAEDNLKLKMRIE---------VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKS 457

Query: 440 EDSKNIPLEKE 450
             +++I L+ E
Sbjct: 458 TATRDISLDSE 468



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 59/308 (19%), Positives = 120/308 (38%), Gaps = 62/308 (20%)

Query: 143  LEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQR 202
            L + ++E+   L S+ +       ++E + ++Q+      P  D   + ++ E+   V +
Sbjct: 844  LRQTIEEKDRSLGSMKEENNHLQEELERLREEQS---RTAPVADPKTLDSVTELASEVSQ 900

Query: 203  FEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSA 262
               +K  L++  K   K++  +   K    + ++S +   ++++EF   H     + ++A
Sbjct: 901  LNTIKEHLEEEIKHHQKIIEDQNQSKM---QLLQSLQEQKKEMDEFRYQH-----EQMNA 952

Query: 263  TEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCD----FQLLSEEKL 318
            T  Q          ++ K  E     L            E + +Q D    FQ    + L
Sbjct: 953  THTQLFLEKDEEIKSLQKTIEQIKTQLHE----------ERQDIQTDNSDIFQETKVQSL 1002

Query: 319  VLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQ 378
             +EN        EK   +   T++ VK +K+++       E K+  EK   + + +DQ+ 
Sbjct: 1003 NIEN------GSEKHDLSKAETERLVKGIKEREL------EIKLLNEKNISLTKQIDQLS 1050

Query: 379  K---------VARLEIENKVL----------------QEQLKQALQEAEKAKHQLNYFLN 413
            K         + + ++E + L                Q+QL+    E EK    LN    
Sbjct: 1051 KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110

Query: 414  QEKLLKSE 421
            +   LK+E
Sbjct: 1111 ENSHLKTE 1118



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 66/362 (18%), Positives = 155/362 (42%), Gaps = 41/362 (11%)

Query: 76  NLLPEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDDMNSFLTY 135
           NL  +++ + + I   + +++ +EE     D+  +E   KH      + + D ++     
Sbjct: 475 NLEAKEQELNQSISEKETLIAEIEEL----DRQNQEA-TKH-----MILIKDQLSKQQNE 524

Query: 136 CSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAE 195
                ++L++ L +E+  +  L +  +  + +  ++ K++ L+Q+E       V LN   
Sbjct: 525 GDSIISKLKQDLNDEKKRVHQL-EDDKMDITKELDVQKEK-LIQSE-------VALNDLH 575

Query: 196 IVR--LVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHS 253
           + +  L  + E L ++L +  +S+V +       KE+  +  +    +  ++ + L   S
Sbjct: 576 LTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDS 635

Query: 254 TDEFKDVSATEPQT-AHSMTNRFNAMLKVFENQANML--ERAVNDQVLLDAEYKQMQCDF 310
              FKD    E +    ++    + + ++ EN   +    +  N++++L  E  + Q + 
Sbjct: 636 NSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEE 695

Query: 311 QLLSEEKLVLEN----ELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKK----- 361
            L    +L LE     E  K++  E         K+ ++   K +K   E S  +     
Sbjct: 696 CLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTS 755

Query: 362 -MSPEKEFKIKEDLDQVQKVARLEIENKVLQ-----EQLKQALQEAEKAKHQLNYFLNQE 415
            +  E E  IK  L+Q + +   E++  + Q     ++ K  L  + + + QL   +N++
Sbjct: 756 ALQLEHEHLIK--LNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKK 813

Query: 416 KL 417
           ++
Sbjct: 814 EI 815


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 66/315 (20%), Positives = 129/315 (40%), Gaps = 34/315 (10%)

Query: 119  EELSLSVGDDMNSFLTYCSQFAA--------QLEEALKEEQNILESLFKWFQWQ------ 164
            EE  L V D + SF      + A        Q + AL+  Q    +  K   WQ      
Sbjct: 805  EERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFT 864

Query: 165  -VNQMEEISKDQTLLQAEPPKPDKTVILN------IAEIVRLVQRFEELKNRLKQRSKSS 217
             V  + ++++   +LQA   +  K   L       + E+   V + EE + RL ++ ++ 
Sbjct: 865  KVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAE 924

Query: 218  VKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNA 277
             ++       +       +  E +  ++E        +E      TE +          A
Sbjct: 925  AELCAEAEETRGRLAARKQELELVVSELEA--RVGEEEECSRQMQTEKKRLQQHIQELEA 982

Query: 278  MLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDK----EKT 333
             L+  E     L+    ++V  +A+ K+ + D  LL ++   L  E + L+D+       
Sbjct: 983  HLEAEEGARQKLQL---EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1039

Query: 334  KPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQ 393
                    K++  ++ K +    D E ++   KE K +++L+++++  RL+ E+  LQEQ
Sbjct: 1040 AAEEEEKVKSLNKLRLKYEATIADMEDRL--RKEEKGRQELEKLKR--RLDGESSELQEQ 1095

Query: 394  LKQALQEAEKAKHQL 408
            + +  Q AE+ + QL
Sbjct: 1096 MVEQQQRAEELRAQL 1110



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 47/221 (21%), Positives = 95/221 (42%), Gaps = 8/221 (3%)

Query: 142  QLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQ 201
            QLEE L+EEQ+  E L   ++  + Q+E ++ + +  ++   K +        +I  L  
Sbjct: 1765 QLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRG 1824

Query: 202  RFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVS 261
            R  E     + R K ++  + SK    E + E       L+ K+    E    +    V 
Sbjct: 1825 RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1884

Query: 262  ATEPQTAHSMTNRF---NAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKL 318
              E + A  + ++    N  +K  + Q   LE A  +     A  +++Q + + ++E   
Sbjct: 1885 -EERRVADQLRDQLEKGNLRVKQLKRQ---LEEAEEEASRAQAGRRRLQRELEDVTESAE 1940

Query: 319  VLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSE 359
             +  E+  L+++ +  P    T + V+ V + ++G + D E
Sbjct: 1941 SMNREVTTLRNRLRRGPL-TFTTRTVRQVFRLEEGVASDEE 1980



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 54/276 (19%), Positives = 117/276 (42%), Gaps = 17/276 (6%)

Query: 138  QFAAQLEEALKEEQNILESLFKWFQWQVNQ-MEEISKDQTLLQAEPPKPDKTVILNIAEI 196
            Q   +L++ L+EE  I E+  +  + +  Q + E+++     +      +KT +   AE+
Sbjct: 1199 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1258

Query: 197  VRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDE 256
              L      L+   ++  +   ++ L     +E +  A     A A+  E+   A +  E
Sbjct: 1259 SELRAELSSLQTARQEGEQRRRRLELQL---QEVQGRAGDGERARAEAAEKLQRAQA--E 1313

Query: 257  FKDVSATEPQTAHSMTNRFNAMLKVFENQAN----MLERAVNDQVLLDAEYKQMQCDFQL 312
             ++VS    + A S T R +  L   E Q +    +L+     ++ L +  + M+ +   
Sbjct: 1314 LENVSGALNE-AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG 1372

Query: 313  LSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGK---SEDSEKKMSPEKEFK 369
            L E+   LE E    +   +   T        +  ++++ G     E++ ++ + E E  
Sbjct: 1373 LREQ---LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1429

Query: 370  IKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAK 405
             +   ++ + V RLE   + LQ++L  A  + E+ +
Sbjct: 1430 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1465


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 66/315 (20%), Positives = 129/315 (40%), Gaps = 34/315 (10%)

Query: 119  EELSLSVGDDMNSFLTYCSQFAA--------QLEEALKEEQNILESLFKWFQWQ------ 164
            EE  L V D + SF      + A        Q + AL+  Q    +  K   WQ      
Sbjct: 797  EERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFT 856

Query: 165  -VNQMEEISKDQTLLQAEPPKPDKTVILN------IAEIVRLVQRFEELKNRLKQRSKSS 217
             V  + ++++   +LQA   +  K   L       + E+   V + EE + RL ++ ++ 
Sbjct: 857  KVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAE 916

Query: 218  VKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNA 277
             ++       +       +  E +  ++E        +E      TE +          A
Sbjct: 917  AELCAEAEETRGRLAARKQELELVVSELEA--RVGEEEECSRQMQTEKKRLQQHIQELEA 974

Query: 278  MLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDK----EKT 333
             L+  E     L+    ++V  +A+ K+ + D  LL ++   L  E + L+D+       
Sbjct: 975  HLEAEEGARQKLQL---EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1031

Query: 334  KPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQ 393
                    K++  ++ K +    D E ++   KE K +++L+++++  RL+ E+  LQEQ
Sbjct: 1032 AAEEEEKVKSLNKLRLKYEATIADMEDRL--RKEEKGRQELEKLKR--RLDGESSELQEQ 1087

Query: 394  LKQALQEAEKAKHQL 408
            + +  Q AE+ + QL
Sbjct: 1088 MVEQQQRAEELRAQL 1102



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 47/221 (21%), Positives = 95/221 (42%), Gaps = 8/221 (3%)

Query: 142  QLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQ 201
            QLEE L+EEQ+  E L   ++  + Q+E ++ + +  ++   K +        +I  L  
Sbjct: 1757 QLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRG 1816

Query: 202  RFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVS 261
            R  E     + R K ++  + SK    E + E       L+ K+    E    +    V 
Sbjct: 1817 RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1876

Query: 262  ATEPQTAHSMTNRF---NAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKL 318
              E + A  + ++    N  +K  + Q   LE A  +     A  +++Q + + ++E   
Sbjct: 1877 -EERRVADQLRDQLEKGNLRVKQLKRQ---LEEAEEEASRAQAGRRRLQRELEDVTESAE 1932

Query: 319  VLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSE 359
             +  E+  L+++ +  P    T + V+ V + ++G + D E
Sbjct: 1933 SMNREVTTLRNRLRRGPL-TFTTRTVRQVFRLEEGVASDEE 1972



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 54/276 (19%), Positives = 117/276 (42%), Gaps = 17/276 (6%)

Query: 138  QFAAQLEEALKEEQNILESLFKWFQWQVNQ-MEEISKDQTLLQAEPPKPDKTVILNIAEI 196
            Q   +L++ L+EE  I E+  +  + +  Q + E+++     +      +KT +   AE+
Sbjct: 1191 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1250

Query: 197  VRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDE 256
              L      L+   ++  +   ++ L     +E +  A     A A+  E+   A +  E
Sbjct: 1251 SELRAELSSLQTARQEGEQRRRRLELQL---QEVQGRAGDGERARAEAAEKLQRAQA--E 1305

Query: 257  FKDVSATEPQTAHSMTNRFNAMLKVFENQAN----MLERAVNDQVLLDAEYKQMQCDFQL 312
             ++VS    + A S T R +  L   E Q +    +L+     ++ L +  + M+ +   
Sbjct: 1306 LENVSGALNE-AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG 1364

Query: 313  LSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGK---SEDSEKKMSPEKEFK 369
            L E+   LE E    +   +   T        +  ++++ G     E++ ++ + E E  
Sbjct: 1365 LREQ---LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1421

Query: 370  IKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAK 405
             +   ++ + V RLE   + LQ++L  A  + E+ +
Sbjct: 1422 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1457


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 66/315 (20%), Positives = 129/315 (40%), Gaps = 34/315 (10%)

Query: 119  EELSLSVGDDMNSFLTYCSQFAA--------QLEEALKEEQNILESLFKWFQWQ------ 164
            EE  L V D + SF      + A        Q + AL+  Q    +  K   WQ      
Sbjct: 838  EERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFT 897

Query: 165  -VNQMEEISKDQTLLQAEPPKPDKTVILN------IAEIVRLVQRFEELKNRLKQRSKSS 217
             V  + ++++   +LQA   +  K   L       + E+   V + EE + RL ++ ++ 
Sbjct: 898  KVKPLLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAE 957

Query: 218  VKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNA 277
             ++       +       +  E +  ++E        +E      TE +          A
Sbjct: 958  AELCAEAEETRGRLAARKQELELVVSELEA--RVGEEEECSRQMQTEKKRLQQHIQELEA 1015

Query: 278  MLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDK----EKT 333
             L+  E     L+    ++V  +A+ K+ + D  LL ++   L  E + L+D+       
Sbjct: 1016 HLEAEEGARQKLQL---EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1072

Query: 334  KPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQ 393
                    K++  ++ K +    D E ++   KE K +++L+++++  RL+ E+  LQEQ
Sbjct: 1073 AAEEEEKVKSLNKLRLKYEATIADMEDRL--RKEEKGRQELEKLKR--RLDGESSELQEQ 1128

Query: 394  LKQALQEAEKAKHQL 408
            + +  Q AE+ + QL
Sbjct: 1129 MVEQQQRAEELRAQL 1143



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 47/221 (21%), Positives = 95/221 (42%), Gaps = 8/221 (3%)

Query: 142  QLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQ 201
            QLEE L+EEQ+  E L   ++  + Q+E ++ + +  ++   K +        +I  L  
Sbjct: 1798 QLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRG 1857

Query: 202  RFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVS 261
            R  E     + R K ++  + SK    E + E       L+ K+    E    +    V 
Sbjct: 1858 RLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVE 1917

Query: 262  ATEPQTAHSMTNRF---NAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKL 318
              E + A  + ++    N  +K  + Q   LE A  +     A  +++Q + + ++E   
Sbjct: 1918 -EERRVADQLRDQLEKGNLRVKQLKRQ---LEEAEEEASRAQAGRRRLQRELEDVTESAE 1973

Query: 319  VLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSE 359
             +  E+  L+++ +  P    T + V+ V + ++G + D E
Sbjct: 1974 SMNREVTTLRNRLRRGPL-TFTTRTVRQVFRLEEGVASDEE 2013



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 54/276 (19%), Positives = 117/276 (42%), Gaps = 17/276 (6%)

Query: 138  QFAAQLEEALKEEQNILESLFKWFQWQVNQ-MEEISKDQTLLQAEPPKPDKTVILNIAEI 196
            Q   +L++ L+EE  I E+  +  + +  Q + E+++     +      +KT +   AE+
Sbjct: 1232 QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEV 1291

Query: 197  VRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDE 256
              L      L+   ++  +   ++ L     +E +  A     A A+  E+   A +  E
Sbjct: 1292 SELRAELSSLQTARQEGEQRRRRLELQL---QEVQGRAGDGERARAEAAEKLQRAQA--E 1346

Query: 257  FKDVSATEPQTAHSMTNRFNAMLKVFENQAN----MLERAVNDQVLLDAEYKQMQCDFQL 312
             ++VS    + A S T R +  L   E Q +    +L+     ++ L +  + M+ +   
Sbjct: 1347 LENVSGALNE-AESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG 1405

Query: 313  LSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGK---SEDSEKKMSPEKEFK 369
            L E+   LE E    +   +   T        +  ++++ G     E++ ++ + E E  
Sbjct: 1406 LREQ---LEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1462

Query: 370  IKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAK 405
             +   ++ + V RLE   + LQ++L  A  + E+ +
Sbjct: 1463 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1498


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 70/327 (21%), Positives = 137/327 (41%), Gaps = 41/327 (12%)

Query: 141 AQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLV 200
           A L+  L   QN L+   +       Q+++++      Q    + +  +     + + L 
Sbjct: 663 ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722

Query: 201 QRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDV 260
           Q+ EEL+ ++K+    S++V  SK                  Q +++  +    +   ++
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKE-----------------QALQDLQQQRQLNTDLEL 765

Query: 261 SATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQ-MQCDFQLLSEEKLV 319
            ATE      M     +  ++   + +    ++  ++    E KQ ++ DF+ LS+E  +
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825

Query: 320 LENELQK-----LKDKEKTKPTNNRTKKAVKTVKKK-----DKGKSEDSEKKMSPEKEFK 369
              EL       + + +K K         + TVK K     D  K+  SE +   +K   
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA 885

Query: 370 IKEDLDQVQKVAR----LEIENKVL-QEQLKQALQEAEKAKHQLNYFLN--QEKL----- 417
              DL++  K  +    +++EN +  Q++LK++L++ ++A HQL   LN  QE+L     
Sbjct: 886 AILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQN 945

Query: 418 -LKSEGKTETTMQVGNSQTKVKGEDSK 443
            LK   K E  +Q   ++ K   E  K
Sbjct: 946 TLKQNEKEEQQLQGNINELKQSSEQKK 972



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 79/365 (21%), Positives = 158/365 (43%), Gaps = 69/365 (18%)

Query: 145 EALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFE 204
           E LK+E   L+S +   +  ++Q          L++E  K  + V + + E+    Q+ +
Sbjct: 249 EKLKDECKKLQSQYASSEATISQ----------LRSELAKGPQEVAVYVQEL----QKLK 294

Query: 205 ELKNRLKQRSKSSVKVMLSKTMD-----KENRPEAVKSCEALAQKIEEFLEAHSTDEFKD 259
              N L Q++++  + +L K  D     +++  E+V      A   ++ L+         
Sbjct: 295 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLS 354

Query: 260 VSATEPQTAH-SMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKL 318
            S T     H  ++ +  A  K+ E  + +  +  +    L AE+KQ+Q   +   +  L
Sbjct: 355 ASETSLHRIHVELSEKGEATQKLKEELSEVETKYQH----LKAEFKQLQQQREEKEQHGL 410

Query: 319 VLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQ 378
            L++E+ +L  K     T  +  +A   +K+         ++++S EK       +D+ Q
Sbjct: 411 QLQSEINQLHSK--LLETERQLGEAHGRLKE---------QRQLSSEKL------MDKEQ 453

Query: 379 KVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQE------------KLLKSEGKTET 426
           +VA L+++   L+EQLK+ +  + + +HQL+    Q             KL +++   E 
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513

Query: 427 TM-QVGNSQTKVKG------EDSKNIPLEKETRKSLVSDSGGQRTSDKIQEYPQITAQSG 479
            + Q+G+   K++       +  +NI L ++ R+ L +         KIQ     TA   
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYA---------KIQAGEGETAVLN 564

Query: 480 RLIEK 484
           +L EK
Sbjct: 565 QLQEK 569



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 77/327 (23%), Positives = 140/327 (42%), Gaps = 42/327 (12%)

Query: 133 LTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILN 192
           +T   Q    L+ +LKEE        KW+  ++ +  E+ K Q L Q E  KPD  V  +
Sbjct: 85  VTLLRQEVQDLQASLKEE--------KWYSEELKK--ELEKYQGLQQQEA-KPDGLVTDS 133

Query: 193 IAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAH 252
            AE+  L Q+ EE      Q    ++K M      K            LA +I +    +
Sbjct: 134 SAELQSLEQQLEE-----AQTENFNIKQMKDLFEQK---------AAQLATEIADIKSKY 179

Query: 253 STDEFKDVSATEPQTAHSMTNRFNAMLKVFEN-QANMLER-AVNDQVLLDAEYKQMQCDF 310
             DE + +     Q    +T   N    V ++ +  +L+R  + D  +L  E  Q+Q   
Sbjct: 180 --DEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQ--- 234

Query: 311 QLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKI 370
            L+    L  E E +KLKD+ K   +   + +A  +  + +  K    E  +  ++  K+
Sbjct: 235 TLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKG-PQEVAVYVQELQKL 293

Query: 371 KEDLDQVQKVARLEIENKVLQEQ----LKQALQEAEKAKHQLNYFLNQEKL----LKSE- 421
           K  ++++ +  +   EN + +EQ    L++   E   +K  +   L+Q+ L    L+S  
Sbjct: 294 KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRL 353

Query: 422 GKTETTMQVGNSQTKVKGEDSKNIPLE 448
             +ET++   + +   KGE ++ +  E
Sbjct: 354 SASETSLHRIHVELSEKGEATQKLKEE 380



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 74/348 (21%), Positives = 145/348 (41%), Gaps = 63/348 (18%)

Query: 138  QFAAQLEEALKEEQNILESLFK------WFQWQVNQMEE--ISKDQTLLQAEPPKPDKTV 189
            Q   Q+E  LKE++ + +SL K        + ++N M+E  I    TL Q E  K ++ +
Sbjct: 900  QLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE--KEEQQL 957

Query: 190  ILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFL 249
              NI E+    ++  E K +  +  +  +K+ + +  + EN+ +     + L Q  +E  
Sbjct: 958  QGNINEL----KQSSEQKKKQIEALQGELKIAVLQKTELENKLQ-----QQLTQAAQEL- 1007

Query: 250  EAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCD 309
                        A E +    + N +    + F+   +      ++ +    + K ++  
Sbjct: 1008 ------------AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK 1055

Query: 310  FQLLSEEKLVLENEL---QKLKDKEKTKPTNNRTKKAVKTVKKKDKGKS-EDSEKKMSPE 365
              L  E+ +   N++    KL  + KT         A K  + +++ K+ +D +K    E
Sbjct: 1056 LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQK----E 1111

Query: 366  KEFKIKEDLDQVQKVA-------RLEIENKVLQEQLK----QALQEAEKAKHQLNYFLNQ 414
            K  K KE +++  K+A       R E E   L E+LK    ++++E    K      + Q
Sbjct: 1112 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171

Query: 415  EKLLKSEGKTET----------TMQVGNSQTKVKGEDSKNIPLEKETR 452
            +  L+ +GK ++            Q+   Q K + E+ K   +EKE +
Sbjct: 1172 K--LELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAK 1217



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 94/423 (22%), Positives = 174/423 (41%), Gaps = 83/423 (19%)

Query: 117  EHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQT 176
            + +E S  +  ++NS      Q    L++  KEEQ +        Q  +N++++ S +Q 
Sbjct: 921  KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL--------QGNINELKQ-SSEQK 971

Query: 177  LLQAEPPKPD-KTVILNIAEIV-----RLVQRFEEL---KNRLK------QRSKSSVKVM 221
              Q E  + + K  +L   E+      +L Q  +EL   K ++       ++S+ + K +
Sbjct: 972  KKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL 1031

Query: 222  LSKTMDKENRPEA----VKSCEALAQKIEEFLEAHSTD---------EFKDVSATEPQTA 268
             S    +E+   A    +KS E      +E L ++            E K   AT  Q +
Sbjct: 1032 QSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDS 1091

Query: 269  ----HSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQC----DFQLLSEE---- 316
                  +  R  A+  + + ++   +  VN++  L AE ++++C    +   L+EE    
Sbjct: 1092 AKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEELKSH 1150

Query: 317  KLVLENELQKLKD--------KEKTKPTNNRTKKAVKTVKK-----KDKGKSEDSE-KKM 362
            KL    E+  LKD        K + +   +  K AV+  K+     KD+ K E+ E KK 
Sbjct: 1151 KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210

Query: 363  SPEKEFKIKEDLDQ--------VQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQ 414
              EKE K+  ++ +         +  A+L ++   L E L    +E + ++ +++    Q
Sbjct: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1270

Query: 415  EKLLKSE-GKTETTMQVGNSQTK------VKGEDSKNIPLEKETRKSLVSDSGGQRTSDK 467
               L+ E    E T+Q    + +      +KGE      +EK   K L        T+  
Sbjct: 1271 TDDLRGEIAVLEATVQNNQDERRALLERCLKGEGE----IEKLQTKVLELQRKLDNTTAA 1326

Query: 468  IQE 470
            +QE
Sbjct: 1327 VQE 1329


>gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]
          Length = 761

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 59/246 (23%), Positives = 111/246 (45%), Gaps = 45/246 (18%)

Query: 199 LVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFK 258
           L + F  +++RL    +  + +MLS  ++++++   +    +L QK  E  E  S+   K
Sbjct: 59  LWRSFRSVRSRLYVGREKKLALMLSGLIEEKSK---LLEKFSLVQKEYEGYEVESS--LK 113

Query: 259 DVS----ATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLS 314
           D S    ATE Q+  +   + N      E++   LE+ + ++    +E  ++  D     
Sbjct: 114 DASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMAD----- 168

Query: 315 EEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDL 374
                +   +Q L+D+ K+                    KS+ +E KM+    FKI +  
Sbjct: 169 -----ISKRIQSLEDESKSL-------------------KSQVAEAKMT----FKIFQMN 200

Query: 375 DQVQKVARLEI--ENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGN 432
           ++  K+A  +   EN  LQE  KQ LQEAE  K Q++  LN++K+   + K      + +
Sbjct: 201 EERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSE-LNKQKVTFEDSKVHAEQVLND 259

Query: 433 SQTKVK 438
            ++ +K
Sbjct: 260 KESHIK 265



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 65/299 (21%), Positives = 125/299 (41%), Gaps = 40/299 (13%)

Query: 186 DKTVILNIAEIVRLVQRFEELKNRLKQRS---KSSVKVMLSKTMDKENRPEAVKSCEALA 242
           +K+ +L    +V+      E+++ LK  S   +++    L  T +K NR  +    E L 
Sbjct: 88  EKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILC 147

Query: 243 --QKIEEFLEAHSTDE--FKDVSAT------EPQTAHSMTNRFNAMLKVFENQANMLERA 292
             ++++E    HS  +    D+S        E ++  S         K+F+     L+ A
Sbjct: 148 LEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIA 207

Query: 293 VNDQVLLDAEYKQMQCDFQLLSEEKLVLE--NELQKLK-----DKEKTKPTNNRTKKAVK 345
           + D +  +++ ++ Q   QLL E ++  E  +EL K K      K   +   N  +  +K
Sbjct: 208 IKDALNENSQLQESQK--QLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIK 265

Query: 346 TV-----KKKD------KGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL 394
           T+     K KD      +  ++D   ++    E +    LD   K A   ++  +   +L
Sbjct: 266 TLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGA---LKKLIHAAKL 322

Query: 395 KQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
             +L+  E  ++Q+   L++      + K E T  + N QT+     S+N   E E +K
Sbjct: 323 NASLKTLEGERNQIYIQLSEV----DKTKEELTEHIKNLQTEQASLQSENTHFENENQK 377



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 78/368 (21%), Positives = 142/368 (38%), Gaps = 33/368 (8%)

Query: 96  STLEETYGHCDQNGEEPFVKH-EHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL 154
           S LE+     ++  +E   KH E +EL   +   + S         +Q+ EA        
Sbjct: 139 SELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEA-------- 190

Query: 155 ESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILN-------IAEIVRLVQRFEELK 207
           +  FK FQ    +++   KD     ++  +  K ++         ++E+ +    FE+ K
Sbjct: 191 KMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK 250

Query: 208 NRLKQ---RSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATE 264
              +Q     +S +K +  + +  ++   A    E +       LE +S  E        
Sbjct: 251 VHAEQVLNDKESHIKTLTERLLKMKDW--AAMLGEDITDDDNLELEMNSESENGAYLDNP 308

Query: 265 PQTAHSM---TNRFNAMLKVFENQANMLERAVND----QVLLDAEYKQMQCDFQLLSEEK 317
           P+ A        + NA LK  E + N +   +++    +  L    K +Q +   L  E 
Sbjct: 309 PKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN 368

Query: 318 LVLENELQKLKDKEK--TKPTNNRTKKAVKTVKKKDKGKSEDSEK-KMSPEKEFKIKEDL 374
              ENE QKL+ K K  T+       K  + +  ++  + E  EK     EK     E+L
Sbjct: 369 THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEEL 428

Query: 375 DQVQKVAR-LEIE-NKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGN 432
           +  +K A+ LE E  + +     Q +   +KA        N E+ L    K     +   
Sbjct: 429 ETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKL 488

Query: 433 SQTKVKGE 440
           ++T++K E
Sbjct: 489 TETELKFE 496


>gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]
          Length = 804

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 59/246 (23%), Positives = 111/246 (45%), Gaps = 45/246 (18%)

Query: 199 LVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFK 258
           L + F  +++RL    +  + +MLS  ++++++   +    +L QK  E  E  S+   K
Sbjct: 59  LWRSFRSVRSRLYVGREKKLALMLSGLIEEKSK---LLEKFSLVQKEYEGYEVESS--LK 113

Query: 259 DVS----ATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLS 314
           D S    ATE Q+  +   + N      E++   LE+ + ++    +E  ++  D     
Sbjct: 114 DASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMAD----- 168

Query: 315 EEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDL 374
                +   +Q L+D+ K+                    KS+ +E KM+    FKI +  
Sbjct: 169 -----ISKRIQSLEDESKSL-------------------KSQVAEAKMT----FKIFQMN 200

Query: 375 DQVQKVARLEI--ENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGN 432
           ++  K+A  +   EN  LQE  KQ LQEAE  K Q++  LN++K+   + K      + +
Sbjct: 201 EERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSE-LNKQKVTFEDSKVHAEQVLND 259

Query: 433 SQTKVK 438
            ++ +K
Sbjct: 260 KESHIK 265



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 65/299 (21%), Positives = 125/299 (41%), Gaps = 40/299 (13%)

Query: 186 DKTVILNIAEIVRLVQRFEELKNRLKQRS---KSSVKVMLSKTMDKENRPEAVKSCEALA 242
           +K+ +L    +V+      E+++ LK  S   +++    L  T +K NR  +    E L 
Sbjct: 88  EKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILC 147

Query: 243 --QKIEEFLEAHSTDE--FKDVSAT------EPQTAHSMTNRFNAMLKVFENQANMLERA 292
             ++++E    HS  +    D+S        E ++  S         K+F+     L+ A
Sbjct: 148 LEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIA 207

Query: 293 VNDQVLLDAEYKQMQCDFQLLSEEKLVLE--NELQKLK-----DKEKTKPTNNRTKKAVK 345
           + D +  +++ ++ Q   QLL E ++  E  +EL K K      K   +   N  +  +K
Sbjct: 208 IKDALNENSQLQESQK--QLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIK 265

Query: 346 TV-----KKKD------KGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL 394
           T+     K KD      +  ++D   ++    E +    LD   K A   ++  +   +L
Sbjct: 266 TLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGA---LKKLIHAAKL 322

Query: 395 KQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
             +L+  E  ++Q+   L++      + K E T  + N QT+     S+N   E E +K
Sbjct: 323 NASLKTLEGERNQIYIQLSEV----DKTKEELTEHIKNLQTEQASLQSENTHFENENQK 377



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 78/368 (21%), Positives = 142/368 (38%), Gaps = 33/368 (8%)

Query: 96  STLEETYGHCDQNGEEPFVKH-EHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL 154
           S LE+     ++  +E   KH E +EL   +   + S         +Q+ EA        
Sbjct: 139 SELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEA-------- 190

Query: 155 ESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILN-------IAEIVRLVQRFEELK 207
           +  FK FQ    +++   KD     ++  +  K ++         ++E+ +    FE+ K
Sbjct: 191 KMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK 250

Query: 208 NRLKQ---RSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATE 264
              +Q     +S +K +  + +  ++   A    E +       LE +S  E        
Sbjct: 251 VHAEQVLNDKESHIKTLTERLLKMKDW--AAMLGEDITDDDNLELEMNSESENGAYLDNP 308

Query: 265 PQTAHSM---TNRFNAMLKVFENQANMLERAVND----QVLLDAEYKQMQCDFQLLSEEK 317
           P+ A        + NA LK  E + N +   +++    +  L    K +Q +   L  E 
Sbjct: 309 PKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN 368

Query: 318 LVLENELQKLKDKEK--TKPTNNRTKKAVKTVKKKDKGKSEDSEK-KMSPEKEFKIKEDL 374
              ENE QKL+ K K  T+       K  + +  ++  + E  EK     EK     E+L
Sbjct: 369 THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEEL 428

Query: 375 DQVQKVAR-LEIE-NKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGN 432
           +  +K A+ LE E  + +     Q +   +KA        N E+ L    K     +   
Sbjct: 429 ETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKL 488

Query: 433 SQTKVKGE 440
           ++T++K E
Sbjct: 489 TETELKFE 496


>gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]
          Length = 775

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 59/246 (23%), Positives = 111/246 (45%), Gaps = 45/246 (18%)

Query: 199 LVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFK 258
           L + F  +++RL    +  + +MLS  ++++++   +    +L QK  E  E  S+   K
Sbjct: 30  LWRSFRSVRSRLYVGREKKLALMLSGLIEEKSK---LLEKFSLVQKEYEGYEVESS--LK 84

Query: 259 DVS----ATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLS 314
           D S    ATE Q+  +   + N      E++   LE+ + ++    +E  ++  D     
Sbjct: 85  DASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMAD----- 139

Query: 315 EEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDL 374
                +   +Q L+D+ K+                    KS+ +E KM+    FKI +  
Sbjct: 140 -----ISKRIQSLEDESKSL-------------------KSQVAEAKMT----FKIFQMN 171

Query: 375 DQVQKVARLEI--ENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGN 432
           ++  K+A  +   EN  LQE  KQ LQEAE  K Q++  LN++K+   + K      + +
Sbjct: 172 EERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSE-LNKQKVTFEDSKVHAEQVLND 230

Query: 433 SQTKVK 438
            ++ +K
Sbjct: 231 KESHIK 236



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 65/299 (21%), Positives = 125/299 (41%), Gaps = 40/299 (13%)

Query: 186 DKTVILNIAEIVRLVQRFEELKNRLKQRS---KSSVKVMLSKTMDKENRPEAVKSCEALA 242
           +K+ +L    +V+      E+++ LK  S   +++    L  T +K NR  +    E L 
Sbjct: 59  EKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILC 118

Query: 243 --QKIEEFLEAHSTDE--FKDVSAT------EPQTAHSMTNRFNAMLKVFENQANMLERA 292
             ++++E    HS  +    D+S        E ++  S         K+F+     L+ A
Sbjct: 119 LEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIA 178

Query: 293 VNDQVLLDAEYKQMQCDFQLLSEEKLVLE--NELQKLK-----DKEKTKPTNNRTKKAVK 345
           + D +  +++ ++ Q   QLL E ++  E  +EL K K      K   +   N  +  +K
Sbjct: 179 IKDALNENSQLQESQK--QLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIK 236

Query: 346 TV-----KKKD------KGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL 394
           T+     K KD      +  ++D   ++    E +    LD   K A   ++  +   +L
Sbjct: 237 TLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGA---LKKLIHAAKL 293

Query: 395 KQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
             +L+  E  ++Q+   L++      + K E T  + N QT+     S+N   E E +K
Sbjct: 294 NASLKTLEGERNQIYIQLSEV----DKTKEELTEHIKNLQTEQASLQSENTHFENENQK 348



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 78/368 (21%), Positives = 142/368 (38%), Gaps = 33/368 (8%)

Query: 96  STLEETYGHCDQNGEEPFVKH-EHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL 154
           S LE+     ++  +E   KH E +EL   +   + S         +Q+ EA        
Sbjct: 110 SELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEA-------- 161

Query: 155 ESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILN-------IAEIVRLVQRFEELK 207
           +  FK FQ    +++   KD     ++  +  K ++         ++E+ +    FE+ K
Sbjct: 162 KMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK 221

Query: 208 NRLKQ---RSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATE 264
              +Q     +S +K +  + +  ++   A    E +       LE +S  E        
Sbjct: 222 VHAEQVLNDKESHIKTLTERLLKMKDW--AAMLGEDITDDDNLELEMNSESENGAYLDNP 279

Query: 265 PQTAHSM---TNRFNAMLKVFENQANMLERAVND----QVLLDAEYKQMQCDFQLLSEEK 317
           P+ A        + NA LK  E + N +   +++    +  L    K +Q +   L  E 
Sbjct: 280 PKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN 339

Query: 318 LVLENELQKLKDKEK--TKPTNNRTKKAVKTVKKKDKGKSEDSEK-KMSPEKEFKIKEDL 374
              ENE QKL+ K K  T+       K  + +  ++  + E  EK     EK     E+L
Sbjct: 340 THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEEL 399

Query: 375 DQVQKVAR-LEIE-NKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGN 432
           +  +K A+ LE E  + +     Q +   +KA        N E+ L    K     +   
Sbjct: 400 ETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKL 459

Query: 433 SQTKVKGE 440
           ++T++K E
Sbjct: 460 TETELKFE 467


>gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens]
          Length = 792

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 59/246 (23%), Positives = 111/246 (45%), Gaps = 45/246 (18%)

Query: 199 LVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFK 258
           L + F  +++RL    +  + +MLS  ++++++   +    +L QK  E  E  S+   K
Sbjct: 47  LWRSFRSVRSRLYVGREKKLALMLSGLIEEKSK---LLEKFSLVQKEYEGYEVESS--LK 101

Query: 259 DVS----ATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLS 314
           D S    ATE Q+  +   + N      E++   LE+ + ++    +E  ++  D     
Sbjct: 102 DASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMAD----- 156

Query: 315 EEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDL 374
                +   +Q L+D+ K+                    KS+ +E KM+    FKI +  
Sbjct: 157 -----ISKRIQSLEDESKSL-------------------KSQVAEAKMT----FKIFQMN 188

Query: 375 DQVQKVARLEI--ENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGN 432
           ++  K+A  +   EN  LQE  KQ LQEAE  K Q++  LN++K+   + K      + +
Sbjct: 189 EERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSE-LNKQKVTFEDSKVHAEQVLND 247

Query: 433 SQTKVK 438
            ++ +K
Sbjct: 248 KESHIK 253



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 65/299 (21%), Positives = 125/299 (41%), Gaps = 40/299 (13%)

Query: 186 DKTVILNIAEIVRLVQRFEELKNRLKQRS---KSSVKVMLSKTMDKENRPEAVKSCEALA 242
           +K+ +L    +V+      E+++ LK  S   +++    L  T +K NR  +    E L 
Sbjct: 76  EKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILC 135

Query: 243 --QKIEEFLEAHSTDE--FKDVSAT------EPQTAHSMTNRFNAMLKVFENQANMLERA 292
             ++++E    HS  +    D+S        E ++  S         K+F+     L+ A
Sbjct: 136 LEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIA 195

Query: 293 VNDQVLLDAEYKQMQCDFQLLSEEKLVLE--NELQKLK-----DKEKTKPTNNRTKKAVK 345
           + D +  +++ ++ Q   QLL E ++  E  +EL K K      K   +   N  +  +K
Sbjct: 196 IKDALNENSQLQESQK--QLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIK 253

Query: 346 TV-----KKKD------KGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL 394
           T+     K KD      +  ++D   ++    E +    LD   K A   ++  +   +L
Sbjct: 254 TLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGA---LKKLIHAAKL 310

Query: 395 KQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
             +L+  E  ++Q+   L++      + K E T  + N QT+     S+N   E E +K
Sbjct: 311 NASLKTLEGERNQIYIQLSEV----DKTKEELTEHIKNLQTEQASLQSENTHFENENQK 365



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 78/368 (21%), Positives = 142/368 (38%), Gaps = 33/368 (8%)

Query: 96  STLEETYGHCDQNGEEPFVKH-EHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL 154
           S LE+     ++  +E   KH E +EL   +   + S         +Q+ EA        
Sbjct: 127 SELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEA-------- 178

Query: 155 ESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILN-------IAEIVRLVQRFEELK 207
           +  FK FQ    +++   KD     ++  +  K ++         ++E+ +    FE+ K
Sbjct: 179 KMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSK 238

Query: 208 NRLKQ---RSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATE 264
              +Q     +S +K +  + +  ++   A    E +       LE +S  E        
Sbjct: 239 VHAEQVLNDKESHIKTLTERLLKMKDW--AAMLGEDITDDDNLELEMNSESENGAYLDNP 296

Query: 265 PQTAHSM---TNRFNAMLKVFENQANMLERAVND----QVLLDAEYKQMQCDFQLLSEEK 317
           P+ A        + NA LK  E + N +   +++    +  L    K +Q +   L  E 
Sbjct: 297 PKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSEN 356

Query: 318 LVLENELQKLKDKEK--TKPTNNRTKKAVKTVKKKDKGKSEDSEK-KMSPEKEFKIKEDL 374
              ENE QKL+ K K  T+       K  + +  ++  + E  EK     EK     E+L
Sbjct: 357 THFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEEL 416

Query: 375 DQVQKVAR-LEIE-NKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGN 432
           +  +K A+ LE E  + +     Q +   +KA        N E+ L    K     +   
Sbjct: 417 ETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKL 476

Query: 433 SQTKVKGE 440
           ++T++K E
Sbjct: 477 TETELKFE 484


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 91/452 (20%), Positives = 187/452 (41%), Gaps = 45/452 (9%)

Query: 18  PALTTKKGLHNLPLSPELKEKHNAKLIHD-KIEPMVLRSPPTGESILRYALPIPSSKTKN 76
           P  TT  G H+     +   +H   L  + + +   +R     ++ L+ AL       K 
Sbjct: 84  PETTTSGGCHSPEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQ 143

Query: 77  LLPEDEMI-------GKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDDM 129
           L  E   +        K    L+  +S +       D+  EE  +  E + LSL +  + 
Sbjct: 144 LEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEE--LTKERDALSLELYRN- 200

Query: 130 NSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQME------EISKDQTLLQAEPP 183
               T   +   +    L+E+  ++ES     Q  V +++      ++   Q  LQAE  
Sbjct: 201 ----TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEAD 256

Query: 184 KPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQ 243
              K +    A++   V+   EL NRL Q+ +  +     K  ++E         E + +
Sbjct: 257 HLGKELQSVSAKLQAQVEE-NELWNRLNQQQEEKMWRQEEKIQERE---------EKIQE 306

Query: 244 KIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEY 303
           + E+  E       ++    E +       R   M+   E +   LE  +++Q  +  + 
Sbjct: 307 QEEKIREQEEKMRRQEEMMWEKE---EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 363

Query: 304 KQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMS 363
           ++ Q + ++  +EK   E E +  + +EK +    + ++  + ++++++   E  EK   
Sbjct: 364 EKRQEEEKIREQEKRQ-EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWE 422

Query: 364 PEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQ-EKLLKSEG 422
            E+E +     +Q +K+ R E   + ++EQ K+  ++ EK + Q      Q EK+ + EG
Sbjct: 423 QEEEMQ-----EQEEKMRRQE---EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEG 474

Query: 423 K-TETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
           K  E   ++   + K++ ++ K    EK+ R+
Sbjct: 475 KMCEQEAKMQEQEEKMRRQEEKIREQEKKIRE 506



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 59/352 (16%), Positives = 147/352 (41%), Gaps = 27/352 (7%)

Query: 114 VKHEHEELSLSVGD-----DMNSFLTYCSQFAAQLEEALKEEQNI-------LESLFKWF 161
           V+ E  E+ L+V +     +    L    Q  A+ +   KE Q++       +E    W 
Sbjct: 221 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 280

Query: 162 QWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVM 221
           +    Q E++ + +  +Q    K  +     I E    ++R EE+    +++ +   ++M
Sbjct: 281 RLNQQQEEKMWRQEEKIQEREEKIQEQEE-KIREQEEKMRRQEEMMWEKEEKMRRQEEMM 339

Query: 222 LSKTM------DKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRF 275
             K        +K +  E ++  E   Q+ E+  E     E +     + +       + 
Sbjct: 340 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 399

Query: 276 NAMLKVFENQANMLERAVN-----DQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDK 330
               ++ + Q   +          ++ + + E K  + + ++  +EK + E E +K++++
Sbjct: 400 REQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQE-EKIREQ 458

Query: 331 EKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQV-QKVARLEIENKV 389
           E+            +    + + K ++ E+KM  ++E KI+E   ++ ++  ++  + ++
Sbjct: 459 EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE-KIREQEKKIREQEEKIREQEEM 517

Query: 390 LQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGED 441
           +QEQ ++  ++ EK   Q      QE+ ++ + +     +V   Q + K ++
Sbjct: 518 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569


>gi|7705415 hook homolog 1 [Homo sapiens]
          Length = 728

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 83/389 (21%), Positives = 163/389 (41%), Gaps = 41/389 (10%)

Query: 79  PEDEMIGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVG---DDMNSFLT- 134
           P ++ +G++ + LK  +  L+E         E+  ++   EEL + V    D+ NS ++ 
Sbjct: 168 PPNDAVGELEQQLKRALEELQEALA------EKEELRQRCEELDMQVTTLQDEKNSLVSE 221

Query: 135 --YCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILN 192
               ++   QL+ +  +   ++   +   Q Q+ Q++E +      + E  K D  V   
Sbjct: 222 NEMMNEKLDQLDGSFDDPNTVVAKKYFHAQLQLEQLQEEN-----FRLEAAKDDYRVHCE 276

Query: 193 IAE--IVRLVQRFEELKNRLKQRSKSSVKV-MLSKTMDKENRPEAVKSCEALAQKIEEFL 249
             E  ++    R +EL +  ++      ++ +L  T DK N+ E+  + E   QK+++  
Sbjct: 277 ELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLES--TVEIYRQKLQDLN 334

Query: 250 EAHSTDEFKDVSATEPQTAHSMTNRFNAMLKV--FENQANMLERAVND-QVLLDAEYKQM 306
           +     + K +  T     H+  +    + K      Q    +R V D  V L +E K+ 
Sbjct: 335 DLRK--QVKTLQETNMMYMHNTVSLEEELKKANAARTQLETYKRQVQDLHVKLSSESKRA 392

Query: 307 QCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVK----KKDKGKSEDSEKKM 362
                L  E K + E     LK+KE+     +  K+  + ++    ++D     D+    
Sbjct: 393 DT---LAFEMKRLEEKHEALLKEKERLIEQRDTLKETNEELRCSQVQQDHLNQTDASATK 449

Query: 363 SPEKEFKIKEDLDQVQKVARLEIENKVLQEQLK-------QALQEAEKAKHQLNYFLNQE 415
           S E        ++  +   RL+ ENK+L+ Q +       + LQE  + KH+    L  E
Sbjct: 450 SYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGSENERIEELQEQLEQKHRKMNELETE 509

Query: 416 KLLKSEGKTETTMQVGNSQTKVKGEDSKN 444
           + L  E   E   Q+ + Q  ++ + SK+
Sbjct: 510 QRLSKERIRELQQQIEDLQKSLQEQGSKS 538


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 83/378 (21%), Positives = 168/378 (44%), Gaps = 37/378 (9%)

Query: 89  KHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDDMNSFLTYCSQFAAQLEEALK 148
           K L+ +    EE     DQ  +    KH  EE   S+ ++ + +++      + L++ L+
Sbjct: 184 KSLRRIAELREEL--QMDQQAK----KHLQEEFDASL-EEKDQYISVLQTQVSLLKQRLR 236

Query: 149 EEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKN 208
                ++ L    Q +        ++      EP   D T +  +  + + V+R E L  
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK 296

Query: 209 RLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTA 268
           R K+  +S  +     T +KE   E +   +   Q++E+  + H  ++ K +  T+ + A
Sbjct: 297 RCKETIQSHKEQCTLLTSEKEALQEQL---DERLQELEKIKDLHMAEKTKLI--TQLRDA 351

Query: 269 HSMTNRF--NAMLKVFENQANM---LERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENE 323
            ++  +   +  + + E +  M   LE    +   L +  KQM    + L E+K   ++E
Sbjct: 352 KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQK--EKSE 409

Query: 324 LQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARL 383
               ++ EK   T  +T++A + +K +   + +  E K S E+   ++++L +V++   +
Sbjct: 410 RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE-KTSEEERISLQQELSRVKQEV-V 467

Query: 384 EIENKVLQEQLK--QALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGED 441
           ++  K  +EQ+   Q L E E A+        +++L K   K +T  +    Q KV  E 
Sbjct: 468 DVMKKSSEEQIAKLQKLHEKELAR-------KEQELTK---KLQTREREFQEQMKVALEK 517

Query: 442 SKN----IPLEKETRKSL 455
           S++    I  EKE ++SL
Sbjct: 518 SQSEYLKISQEKEQQESL 535



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 72/379 (18%), Positives = 158/379 (41%), Gaps = 48/379 (12%)

Query: 143 LEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKP----DKTVILNIAEIVR 198
           L++ +K ++N+L+   +  Q    Q   ++ ++  LQ +  +     +K   L++AE  +
Sbjct: 284 LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTK 343

Query: 199 LVQRFEELKNRLKQRSK------SSVKVMLSKTMDKENRPEA-----VKSCEALAQKIEE 247
           L+ +  + KN ++Q  +      +  K  + +T++ +    A     +K      +++ E
Sbjct: 344 LITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELRE 403

Query: 248 FLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEY---K 304
             E      F+++         +   R     ++ E    + + +  +++ L  E    K
Sbjct: 404 QKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK 463

Query: 305 QMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSP 364
           Q   D    S E+ + +  LQKL +KE  +     TKK     ++  +      EK  S 
Sbjct: 464 QEVVDVMKKSSEEQIAK--LQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQS- 520

Query: 365 EKEFKIKEDLDQVQKVA--RLEIENKVL----QEQLKQALQEAEKAKHQLNYFLNQEKLL 418
            +  KI ++ +Q + +A   LE++ K +    + +L+   QEAE  +          ++L
Sbjct: 521 -EYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYR---------TRIL 570

Query: 419 KSEGKTETTMQVGNSQTK--------VKGEDSKNIPLEKETRKSLVSDSGGQRT---SDK 467
           + E   E ++Q   +Q+K         K + +K I +  E  K+ +     Q+    ++K
Sbjct: 571 ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEK 630

Query: 468 IQEYPQITAQSGRLIEKRC 486
           +Q   Q        + ++C
Sbjct: 631 LQVLKQQYQTEMEKLREKC 649



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 68/332 (20%), Positives = 151/332 (45%), Gaps = 29/332 (8%)

Query: 139  FAAQLEEALKEE----QNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIA 194
            + ++LE+  KE+    Q ++E      Q +  Q +EI   + L Q    K D   ILN  
Sbjct: 888  YESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI---EILTQKLSAKEDSIHILN-E 943

Query: 195  EIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKEN--RPEAVKSCEALAQKIEEF---- 248
            E     +  E+   ++KQ++K   + +  K +D+E   + E   +   L+QK ++F    
Sbjct: 944  EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKM 1003

Query: 249  ---LEAHS---TDEFKDVSATEPQTAHSMT----NRFNAMLKVFENQANMLERAVNDQVL 298
                +A+S   +D    +   + +   S+T       N ++ ++E + N  ++A   Q +
Sbjct: 1004 LEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLN--QQAEELQEI 1061

Query: 299  LDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDS 358
             + + ++ + +   L ++ L+   E +++ +KE T       K+     + +++ K + +
Sbjct: 1062 HEIQLQEKEQEVAELKQKILLFGCEKEEM-NKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120

Query: 359  EKKMSPEKEFKIKEDLDQVQKVARLEI-ENKVLQEQLKQALQEAEKAKHQLNYFLNQEKL 417
                  + E K+K  L++++      + EN  LQEQL +    AE+ K +++   ++ K 
Sbjct: 1121 HVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKT 1180

Query: 418  LKSEGKT-ETTMQVGNSQTKVKGEDSKNIPLE 448
               E ++ +++ +  N   + K  + K +  E
Sbjct: 1181 TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 63/309 (20%), Positives = 137/309 (44%), Gaps = 34/309 (11%)

Query: 142  QLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQ 201
            Q++  +KE +  ++   K  + Q+NQ+E + K++          DK +  + A +  L  
Sbjct: 735  QVDSIIKEHEVSIQRTEKALKDQINQLELLLKER----------DKHLKEHQAHVENLEA 784

Query: 202  RFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHS-----TDE 256
              +  +  L+Q   +S K+ + ++       +     E LAQ  ++ L+  +     T +
Sbjct: 785  DIKRSEGELQQ---ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ 841

Query: 257  FKDVSATEPQT-----AHSMTNRFNAMLKVFENQANMLERAVN------DQVLLDAEYKQ 305
              +V A +        AH +  +   +++  E Q + +E+ V       +  L D   +Q
Sbjct: 842  VAEVEAQKKDVCTELDAHKI--QVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ 899

Query: 306  MQCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPE 365
             Q    L+ +E ++L+    + K+ E      +  + ++  + ++ + K ++ EKKM   
Sbjct: 900  EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKV 959

Query: 366  KEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTE 425
            K+ K KE + +  K   L+ E K+ +E    AL+ ++K K Q N  + +     S G ++
Sbjct: 960  KQ-KAKE-MQETLKKKLLDQEAKLKKELENTALELSQKEK-QFNAKMLEMAQANSAGISD 1016

Query: 426  TTMQVGNSQ 434
               ++  +Q
Sbjct: 1017 AVSRLETNQ 1025



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 73/372 (19%), Positives = 162/372 (43%), Gaps = 42/372 (11%)

Query: 114  VKHEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISK 173
            +K  HE+ + S+ D    F     + A QL+   K+ + +LE+       + N++  IS 
Sbjct: 1188 LKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEA-------KTNELINISS 1240

Query: 174  DQT--LLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLS---KTMDK 228
             +T  +L        +T  +  A +++      EL+ +L+Q ++    + +S    T   
Sbjct: 1241 SKTNAILSRISHCQHRTTKVKEALLIKTC-TVSELEAQLRQLTEEQNTLNISFQQATHQL 1299

Query: 229  ENRPEAVKSCEALAQKI---EEFLEAHSTDEFKDVSATE---PQTAHSMTNRFNAM-LKV 281
            E +   +KS +A  + +   +E L+    ++ +  S  E    Q    ++   NA+ L  
Sbjct: 1300 EEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMK 1359

Query: 282  FENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTK------- 334
             E +   +E +   + L D    Q+Q    L  +E  +  + L+K  D+EK +       
Sbjct: 1360 EELKEKKVEISSLSKQLTDLNV-QLQNSISLSEKEAAI--SSLRKQYDEEKCELLDQVQD 1416

Query: 335  ---PTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQ 391
                 +  +K+ +  +++ D   ++ SE K   +  F   ++      V  L+I+ ++  
Sbjct: 1417 LSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN-----TVKELQIQLELKS 1471

Query: 392  EQLKQALQEAEKAKHQLNYFLNQEKLLKSE---GKTETTMQVGNSQTKVKGEDSKNIPLE 448
            ++  +  ++    K +L+    +   LK E    K++   +  N +T++K + ++ + LE
Sbjct: 1472 KEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531

Query: 449  KE-TRKSLVSDS 459
               T+K++  +S
Sbjct: 1532 DHITQKTIEIES 1543



 Score = 35.8 bits (81), Expect = 0.090
 Identities = 88/453 (19%), Positives = 184/453 (40%), Gaps = 62/453 (13%)

Query: 2    KPVKHL-LTTSNKSANVPALTTKKGLHNLPLSPELKEKHNAKLIHDKIEPMVLRSPPTGE 60
            K ++H+ L+  +K   + AL  +    +     ELK K   K+    I+  +L      E
Sbjct: 1606 KELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIA--AIKKQLLSQMEEKE 1663

Query: 61   SILRYALPIPSSKTKNLLPEDEMIGKIIKH-LKMVVSTLEETYGHCDQNGEEPFVKHEHE 119
               +       S+    L E E    I++  LK V S+  ET     ++ +      E E
Sbjct: 1664 EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL-IVPRSAKNVAAYTEQE 1722

Query: 120  ELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL--------ESLFKWFQWQVNQMEEI 171
            E      D          +  + L+  L E++ +L        E++   F+ +    E +
Sbjct: 1723 E-----ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL 1777

Query: 172  SK----------DQTL---LQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSK-SS 217
             K          DQ++   LQ E  + +K   L +A+ V      E  KN ++ +    +
Sbjct: 1778 IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEK----EGGKNNIQAKQNLEN 1833

Query: 218  VKVMLSKTMDKENRPEAVKSCEALAQKIEEF-------LEAHSTDEFKDVSATEPQTAHS 270
            V   + KT+ ++       +C+ L QKI+E         E H  +  +  S  E   A  
Sbjct: 1834 VFDDVQKTLQEKEL-----TCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQ 1888

Query: 271  MTNRFNAMLKVFENQANMLERA--VNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLK 328
              +  N   ++ E       ++  V  ++L + E +    +F+L   E+           
Sbjct: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER----------- 1937

Query: 329  DKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENK 388
            +K+K      R +K ++ ++K+ + + E  +K+   E+E KIK++ + ++      ++ +
Sbjct: 1938 EKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLK-Q 1996

Query: 389  VLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSE 421
            +++E   Q  Q+ ++ +  +   +N+ + +++E
Sbjct: 1997 LMREFNTQLAQKEQELEMTIKETINKAQEVEAE 2029



 Score = 33.1 bits (74), Expect = 0.58
 Identities = 52/331 (15%), Positives = 130/331 (39%), Gaps = 12/331 (3%)

Query: 84   IGKIIKHLKMVVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDDMNSFLTYCSQFAAQL 143
            I  + K L  +   L+ +    ++      ++ +++E    + D +          + + 
Sbjct: 1369 ISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428

Query: 144  EEALKEEQNILESLFKW-------FQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEI 196
              AL++  +      +W       F    N ++E+     L   E  + D+ + L   E+
Sbjct: 1429 ISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEEL 1488

Query: 197  VRLVQRFEELKNRLKQ-RSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTD 255
             +  +RF+ LK  ++  +SK   K      ++ E + +  +  E      ++ +E  S +
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKK---ESNLETELKSQTARIMELEDHITQKTIEIESLN 1545

Query: 256  E-FKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLS 314
            E  K+ +  +      +  +     ++ E + N ++ A    + L+ +   M+ + +   
Sbjct: 1546 EVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKK 1605

Query: 315  EEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDL 374
            +E   +   ++  +++ K       ++ A K  + K K + + +  K     + + KE+ 
Sbjct: 1606 KELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ 1665

Query: 375  DQVQKVARLEIENKVLQEQLKQALQEAEKAK 405
             +    + L   N  LQE+ ++     EK K
Sbjct: 1666 YKKGTESHLSELNTKLQEREREVHILEEKLK 1696


>gi|190194355 p90 autoantigen [Homo sapiens]
          Length = 905

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 65/280 (23%), Positives = 134/280 (47%), Gaps = 29/280 (10%)

Query: 191 LNIAEIVRLVQRFEELKNRLKQRSKSSV----KVMLSKTMDKENRPEAVKSCEALAQKIE 246
           LNI E++  +Q    +K+++     S +    ++ LS    KE+R + +   +ALA    
Sbjct: 595 LNIEELIEKLQSGMVVKDQICDVRISDIMDVYEMKLSTLASKESRLQDLLETKALALAQA 654

Query: 247 EFLEAHSTDEFKDVSATEPQTAHSM---TNRFNAMLKVF-ENQANMLERAVNDQVLLDAE 302
           + L A    + +  + TE +T  SM     R N  L V  + Q    ERA +D   L   
Sbjct: 655 DRLIAQHRCQ-RTQAETEARTLASMLREVERKNEELSVLLKAQQVESERAQSDIEHLFQH 713

Query: 303 YKQMQCDFQLLSEEKLVLENELQKLKDKEKTKPTN-------NRTKKAVKTVKKKDKGKS 355
            ++++    +  E +++ ++ ++ L+  E T+  N       +   K ++TVKK ++   
Sbjct: 714 NRKLE---SVAEEHEILTKSYMELLQRNESTEKKNKDLQITCDSLNKQIETVKKLNESLK 770

Query: 356 EDSEKKMSP--EKEFKIKED----LDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLN 409
           E +EK ++   EKE + KE     +D+  K+A L  + KV +E++K   +E E  +  ++
Sbjct: 771 EQNEKSIAQLIEKEEQRKEVQNQLVDREHKLANLHQKTKVQEEKIKTLQKEREDKEETID 830

Query: 410 YFLNQ----EKLLKSEGKTETTMQVGNSQTKVKGEDSKNI 445
               +    E++ K      ++++V  +Q + + E+ +++
Sbjct: 831 ILRKELSRTEQIRKELSIKASSLEVQKAQLEGRLEEKESL 870


>gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]
          Length = 284

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 60/253 (23%), Positives = 112/253 (44%), Gaps = 25/253 (9%)

Query: 219 KVMLSKTMDKENRPEAVKSCEA---LAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRF 275
           K M    +DKEN  +  +  EA    A+   + LE       K +  TE +      +++
Sbjct: 6   KKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDEL-----DKY 60

Query: 276 NAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEE----KLVLENELQKLKDKE 331
           +  LK  + +  + E+   D    +A+   +    QL+ EE    +  L   LQKL++ E
Sbjct: 61  SEALKDAQEKLELAEKKATDA---EADVASLNRRIQLVEEELDRAQERLATALQKLEEAE 117

Query: 332 KTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLD-QVQKVARLEIENKVL 390
           K    + R  K +++  +KD+ K E  E ++   K   I ED D + ++VAR  +   ++
Sbjct: 118 KAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKH--IAEDADRKYEEVARKLV---II 172

Query: 391 QEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEK- 449
           +  L++A + AE ++ Q+     Q +++    K     +   SQ + + E+   +  +K 
Sbjct: 173 ESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKL 232

Query: 450 ---ETRKSLVSDS 459
              ETR      S
Sbjct: 233 KEAETRAEFAERS 245



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 51/254 (20%), Positives = 118/254 (46%), Gaps = 28/254 (11%)

Query: 167 QMEEISKDQTLLQAEPPKPDKTVILNIA-----EIVRLVQRFEELKNRLKQRSKSSVKVM 221
           QM ++ K+  L +AE  + DK    + +     E+V L ++ +  ++ L + S++     
Sbjct: 9   QMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQ 68

Query: 222 LSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQT---AHSMTNRFNAM 278
               + ++   +A     +L ++I+  L     D  ++  AT  Q    A    +     
Sbjct: 69  EKLELAEKKATDAEADVASLNRRIQ--LVEEELDRAQERLATALQKLEEAEKAADESERG 126

Query: 279 LKVFENQANMLERAVNDQVLLDAEYKQMQCD----FQLLSEEKLVLENELQKLKDKEKTK 334
           +KV E++A   E  +  Q +   E K +  D    ++ ++ + +++E++L++ +++ +  
Sbjct: 127 MKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAEL- 185

Query: 335 PTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL 394
                ++  V+ ++++ +   +  +  M+ E ++  KED        R E E KVL ++L
Sbjct: 186 -----SEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKED--------RYEEEIKVLSDKL 232

Query: 395 KQALQEAEKAKHQL 408
           K+A   AE A+  +
Sbjct: 233 KEAETRAEFAERSV 246


>gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens]
          Length = 284

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 60/253 (23%), Positives = 112/253 (44%), Gaps = 25/253 (9%)

Query: 219 KVMLSKTMDKENRPEAVKSCEA---LAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRF 275
           K M    +DKEN  +  +  EA    A+   + LE       K +  TE +      +++
Sbjct: 6   KKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDEL-----DKY 60

Query: 276 NAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEE----KLVLENELQKLKDKE 331
           +  LK  + +  + E+   D    +A+   +    QL+ EE    +  L   LQKL++ E
Sbjct: 61  SEALKDAQEKLELAEKKATDA---EADVASLNRRIQLVEEELDRAQERLATALQKLEEAE 117

Query: 332 KTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLD-QVQKVARLEIENKVL 390
           K    + R  K +++  +KD+ K E  E ++   K   I ED D + ++VAR  +   ++
Sbjct: 118 KAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKH--IAEDADRKYEEVARKLV---II 172

Query: 391 QEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEK- 449
           +  L++A + AE ++ Q+     Q +++    K     +   SQ + + E+   +  +K 
Sbjct: 173 ESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKL 232

Query: 450 ---ETRKSLVSDS 459
              ETR      S
Sbjct: 233 KEAETRAEFAERS 245



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 51/254 (20%), Positives = 118/254 (46%), Gaps = 28/254 (11%)

Query: 167 QMEEISKDQTLLQAEPPKPDKTVILNIA-----EIVRLVQRFEELKNRLKQRSKSSVKVM 221
           QM ++ K+  L +AE  + DK    + +     E+V L ++ +  ++ L + S++     
Sbjct: 9   QMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQ 68

Query: 222 LSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQT---AHSMTNRFNAM 278
               + ++   +A     +L ++I+  L     D  ++  AT  Q    A    +     
Sbjct: 69  EKLELAEKKATDAEADVASLNRRIQ--LVEEELDRAQERLATALQKLEEAEKAADESERG 126

Query: 279 LKVFENQANMLERAVNDQVLLDAEYKQMQCD----FQLLSEEKLVLENELQKLKDKEKTK 334
           +KV E++A   E  +  Q +   E K +  D    ++ ++ + +++E++L++ +++ +  
Sbjct: 127 MKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAEL- 185

Query: 335 PTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL 394
                ++  V+ ++++ +   +  +  M+ E ++  KED        R E E KVL ++L
Sbjct: 186 -----SEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKED--------RYEEEIKVLSDKL 232

Query: 395 KQALQEAEKAKHQL 408
           K+A   AE A+  +
Sbjct: 233 KEAETRAEFAERSV 246


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 74/331 (22%), Positives = 139/331 (41%), Gaps = 41/331 (12%)

Query: 99   EETYGHCDQNGEEPFVKHEHEE----LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL 154
            EE     DQ  EE   K   E     L++ + D       + S   A LEE  K  Q  +
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEI 1401

Query: 155  ESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRS 214
            E+L + ++ +    +++ K +  LQ E       +++++    +LV   E+ K R   + 
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDD----LVVDLDNQRQLVSNLEK-KQRKFDQL 1456

Query: 215  KSSVKVMLSKTMDKENRPEAV---KSCEAL--AQKIEEFLEAHST---------DEFKDV 260
             +  K + SK  D+ +R EA    K  +AL  A+ +EE LEA             E +D+
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 261  SATEP---QTAHSMTNRFNAMLKVFENQANMLERAVND-----------QVLLDAEYKQM 306
             +++    +  H +     A+    E     LE   ++           +V + A   Q 
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576

Query: 307  QCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEK 366
            + D Q   E+      +LQ+   + +T+  + R ++A+    KK   K E   K +  + 
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK---KLEGDLKDLELQA 1633

Query: 367  EFKIKEDLDQVQKVARLEIENKVLQEQLKQA 397
            +  IK   + ++++ +L+ + K  Q +L+ A
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 59/316 (18%), Positives = 140/316 (44%), Gaps = 30/316 (9%)

Query: 116  HEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQ----NILE-------SLFKWFQWQ 164
            H  EE  L + D + +F   C  + A+   A +++Q     +++        L  W  W+
Sbjct: 777  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWR 836

Query: 165  ----VNQMEEISKDQTLLQAEPPKPDKT------VILNIAEIVRLVQRFEELKNRLKQRS 214
                V  + ++++ +  +QA+  +  KT          + E+ +   +  E KN L+++ 
Sbjct: 837  LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896

Query: 215  KSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNR 274
            ++  ++       +       +  E +  ++E  LE    D  + + A   + A  M + 
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLD- 954

Query: 275  FNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTK 334
               + +  E +    ++   ++V  +A+ K+++ +  ++ ++   L  E + L+++    
Sbjct: 955  ---LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011

Query: 335  PTN--NRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQE 392
             TN     +KA    K K+K +S  SE ++  +KE K +++L+++++  +LE +     E
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR--KLEGDASDFHE 1069

Query: 393  QLKQALQEAEKAKHQL 408
            Q+     +  + K QL
Sbjct: 1070 QIADLQAQIAELKMQL 1085



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 51/233 (21%), Positives = 100/233 (42%), Gaps = 22/233 (9%)

Query: 141  AQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLV 200
            AQLEE L+EEQ  +E++    +    Q E++S +    ++   K +        +   L 
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798

Query: 201  QRFEELKNRLKQRSKSSVKVMLSKTMDKENRPE--------AVKSCEALAQKIEEFLEAH 252
             +  E++  +K + KS++  + +K    E + E        A KS +   +K++E L   
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL-LQ 1857

Query: 253  STDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQL 312
              DE K     + Q       + NA +K  + Q   LE A  +   ++A  +++Q +   
Sbjct: 1858 VEDERKMAEQYKEQ-----AEKGNARVKQLKRQ---LEEAEEESQRINANRRKLQRELDE 1909

Query: 313  LSEEKLVLENELQKLKDK----EKTKPTNNRTKKAVKTVKKKDKGKSEDSEKK 361
             +E    +  E+  LK K     +T    +R     + ++  D G  E+++ +
Sbjct: 1910 ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENAD-GSEEETDTR 1961



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 68/336 (20%), Positives = 140/336 (41%), Gaps = 41/336 (12%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA-EPPKPDKTVILNIAEIVRLVQR 202
            EEA+K+ +  L++  K FQ ++      S+D+    A E  K  K++  ++ ++   +  
Sbjct: 1641 EEAIKQLRK-LQAQMKDFQRELEDARA-SRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698

Query: 203  FEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSA 262
             E  + +     +   + + S    +    +  +  EA   ++EE LE            
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE----------- 1747

Query: 263  TEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLEN 322
             E     +M++R     +  E  +N  E A         E  + Q     L  +   L +
Sbjct: 1748 -EQGNMEAMSDRVRKATQQAEQLSN--ELATERSTAQKNESARQQ-----LERQNKELRS 1799

Query: 323  ELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK----KMSPEKEFKIKEDLDQVQ 378
            +L +++   K+K  +       K  + +++ + E  EK    K   +K+ K+KE L QV+
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859

Query: 379  KVARLEIENKVLQE-------QLKQALQEAEKAKHQLNYFLNQEKLLKS-EGKTETTMQV 430
               ++  + K   E       QLK+ L+EAE+   ++N   N+ KL +  +  TE+   +
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN--ANRRKLQRELDEATESNEAM 1917

Query: 431  GNSQTKVK-----GEDSKNIPLEKETRKSLVSDSGG 461
            G     +K     G ++  +P  +   + ++ ++ G
Sbjct: 1918 GREVNALKSKLRRGNETSFVPSRRSGGRRVIENADG 1953



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 37/184 (20%), Positives = 88/184 (47%), Gaps = 20/184 (10%)

Query: 289  LERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQK----LKDKEKTKPTNNRTKKAV 344
            L++    Q   + E K+++     L+EEK +L+ +LQ       + E+ +      K+ +
Sbjct: 861  LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920

Query: 345  KTV---------KKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIE-NKVLQEQL 394
            + +         +++D+G+   +E+K   ++   ++E L++ ++ AR +++  KV  E  
Sbjct: 921  EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAK 979

Query: 395  KQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKS 454
             + L++        N  L++E+ L  E  ++ T  +   +     E +KN+   K   +S
Sbjct: 980  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-----EKAKNLTKLKNKHES 1034

Query: 455  LVSD 458
            ++S+
Sbjct: 1035 MISE 1038



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 67/347 (19%), Positives = 149/347 (42%), Gaps = 47/347 (13%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRF 203
            EE ++ +++ L+   +  Q   N+++E+ +  + L  E     +     +     L    
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE----QLQAETELYAEA 906

Query: 204  EELKNRL---KQRSKSSVKVMLSKTMDKENRPEAVKS-CEALAQKIEEFLEAHSTDEF-K 258
            EE++ RL   KQ  +  +  M ++  ++E+R + +++  + +AQ++ +  E    +E  +
Sbjct: 907  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966

Query: 259  DVSATEPQTAHSMTNRFNAMLKVFENQAN-------MLERAVNDQVLLDAEYKQMQCDFQ 311
                 E  TA +   +    + V ++Q N       +LE  ++D     AE ++   +  
Sbjct: 967  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026

Query: 312  LLSEEKLVLENELQ-KLKDKEKTKPTNNRTKKAVK-----------------TVKKKDKG 353
             L  +   + +EL+ +LK +EK++    + K+ ++                    K    
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 354  KSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL---KQALQEAEKAKHQLNY 410
            K E+  +      + +I +  + ++K+  LE     LQE L   + A  +AEK K  L  
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG- 1145

Query: 411  FLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNI-----PLEKETR 452
                E+L   + + E T+    +Q +++ +  + +      L++ETR
Sbjct: 1146 ----EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 74/331 (22%), Positives = 139/331 (41%), Gaps = 41/331 (12%)

Query: 99   EETYGHCDQNGEEPFVKHEHEE----LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL 154
            EE     DQ  EE   K   E     L++ + D       + S   A LEE  K  Q  +
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEI 1408

Query: 155  ESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRS 214
            E+L + ++ +    +++ K +  LQ E       +++++    +LV   E+ K R   + 
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDD----LVVDLDNQRQLVSNLEK-KQRKFDQL 1463

Query: 215  KSSVKVMLSKTMDKENRPEAV---KSCEAL--AQKIEEFLEAHST---------DEFKDV 260
             +  K + SK  D+ +R EA    K  +AL  A+ +EE LEA             E +D+
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 261  SATEP---QTAHSMTNRFNAMLKVFENQANMLERAVND-----------QVLLDAEYKQM 306
             +++    +  H +     A+    E     LE   ++           +V + A   Q 
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 307  QCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEK 366
            + D Q   E+      +LQ+   + +T+  + R ++A+    KK   K E   K +  + 
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK---KLEGDLKDLELQA 1640

Query: 367  EFKIKEDLDQVQKVARLEIENKVLQEQLKQA 397
            +  IK   + ++++ +L+ + K  Q +L+ A
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 59/316 (18%), Positives = 140/316 (44%), Gaps = 30/316 (9%)

Query: 116  HEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQ----NILE-------SLFKWFQWQ 164
            H  EE  L + D + +F   C  + A+   A +++Q     +++        L  W  W+
Sbjct: 784  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWR 843

Query: 165  ----VNQMEEISKDQTLLQAEPPKPDKT------VILNIAEIVRLVQRFEELKNRLKQRS 214
                V  + ++++ +  +QA+  +  KT          + E+ +   +  E KN L+++ 
Sbjct: 844  LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903

Query: 215  KSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNR 274
            ++  ++       +       +  E +  ++E  LE    D  + + A   + A  M + 
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLD- 961

Query: 275  FNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTK 334
               + +  E +    ++   ++V  +A+ K+++ +  ++ ++   L  E + L+++    
Sbjct: 962  ---LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

Query: 335  PTN--NRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQE 392
             TN     +KA    K K+K +S  SE ++  +KE K +++L+++++  +LE +     E
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR--KLEGDASDFHE 1076

Query: 393  QLKQALQEAEKAKHQL 408
            Q+     +  + K QL
Sbjct: 1077 QIADLQAQIAELKMQL 1092



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 51/233 (21%), Positives = 100/233 (42%), Gaps = 22/233 (9%)

Query: 141  AQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLV 200
            AQLEE L+EEQ  +E++    +    Q E++S +    ++   K +        +   L 
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805

Query: 201  QRFEELKNRLKQRSKSSVKVMLSKTMDKENRPE--------AVKSCEALAQKIEEFLEAH 252
             +  E++  +K + KS++  + +K    E + E        A KS +   +K++E L   
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL-LQ 1864

Query: 253  STDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQL 312
              DE K     + Q       + NA +K  + Q   LE A  +   ++A  +++Q +   
Sbjct: 1865 VEDERKMAEQYKEQ-----AEKGNARVKQLKRQ---LEEAEEESQRINANRRKLQRELDE 1916

Query: 313  LSEEKLVLENELQKLKDK----EKTKPTNNRTKKAVKTVKKKDKGKSEDSEKK 361
             +E    +  E+  LK K     +T    +R     + ++  D G  E+++ +
Sbjct: 1917 ATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENAD-GSEEETDTR 1968



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 68/336 (20%), Positives = 140/336 (41%), Gaps = 41/336 (12%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA-EPPKPDKTVILNIAEIVRLVQR 202
            EEA+K+ +  L++  K FQ ++      S+D+    A E  K  K++  ++ ++   +  
Sbjct: 1648 EEAIKQLRK-LQAQMKDFQRELEDARA-SRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705

Query: 203  FEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSA 262
             E  + +     +   + + S    +    +  +  EA   ++EE LE            
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE----------- 1754

Query: 263  TEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLEN 322
             E     +M++R     +  E  +N  E A         E  + Q     L  +   L +
Sbjct: 1755 -EQGNMEAMSDRVRKATQQAEQLSN--ELATERSTAQKNESARQQ-----LERQNKELRS 1806

Query: 323  ELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK----KMSPEKEFKIKEDLDQVQ 378
            +L +++   K+K  +       K  + +++ + E  EK    K   +K+ K+KE L QV+
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866

Query: 379  KVARLEIENKVLQE-------QLKQALQEAEKAKHQLNYFLNQEKLLKS-EGKTETTMQV 430
               ++  + K   E       QLK+ L+EAE+   ++N   N+ KL +  +  TE+   +
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN--ANRRKLQRELDEATESNEAM 1924

Query: 431  GNSQTKVK-----GEDSKNIPLEKETRKSLVSDSGG 461
            G     +K     G ++  +P  +   + ++ ++ G
Sbjct: 1925 GREVNALKSKLRRGNETSFVPSRRSGGRRVIENADG 1960



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 37/184 (20%), Positives = 88/184 (47%), Gaps = 20/184 (10%)

Query: 289  LERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQK----LKDKEKTKPTNNRTKKAV 344
            L++    Q   + E K+++     L+EEK +L+ +LQ       + E+ +      K+ +
Sbjct: 868  LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927

Query: 345  KTV---------KKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIE-NKVLQEQL 394
            + +         +++D+G+   +E+K   ++   ++E L++ ++ AR +++  KV  E  
Sbjct: 928  EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAK 986

Query: 395  KQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKS 454
             + L++        N  L++E+ L  E  ++ T  +   +     E +KN+   K   +S
Sbjct: 987  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-----EKAKNLTKLKNKHES 1041

Query: 455  LVSD 458
            ++S+
Sbjct: 1042 MISE 1045



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 67/347 (19%), Positives = 149/347 (42%), Gaps = 47/347 (13%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRF 203
            EE ++ +++ L+   +  Q   N+++E+ +  + L  E     +     +     L    
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE----QLQAETELYAEA 913

Query: 204  EELKNRL---KQRSKSSVKVMLSKTMDKENRPEAVKS-CEALAQKIEEFLEAHSTDEF-K 258
            EE++ RL   KQ  +  +  M ++  ++E+R + +++  + +AQ++ +  E    +E  +
Sbjct: 914  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973

Query: 259  DVSATEPQTAHSMTNRFNAMLKVFENQAN-------MLERAVNDQVLLDAEYKQMQCDFQ 311
                 E  TA +   +    + V ++Q N       +LE  ++D     AE ++   +  
Sbjct: 974  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033

Query: 312  LLSEEKLVLENELQ-KLKDKEKTKPTNNRTKKAVK-----------------TVKKKDKG 353
             L  +   + +EL+ +LK +EK++    + K+ ++                    K    
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 354  KSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL---KQALQEAEKAKHQLNY 410
            K E+  +      + +I +  + ++K+  LE     LQE L   + A  +AEK K  L  
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG- 1152

Query: 411  FLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNI-----PLEKETR 452
                E+L   + + E T+    +Q +++ +  + +      L++ETR
Sbjct: 1153 ----EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 74/331 (22%), Positives = 139/331 (41%), Gaps = 41/331 (12%)

Query: 99   EETYGHCDQNGEEPFVKHEHEE----LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL 154
            EE     DQ  EE   K   E     L++ + D       + S   A LEE  K  Q  +
Sbjct: 1350 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEI 1408

Query: 155  ESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRS 214
            E+L + ++ +    +++ K +  LQ E       +++++    +LV   E+ K R   + 
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDD----LVVDLDNQRQLVSNLEK-KQRKFDQL 1463

Query: 215  KSSVKVMLSKTMDKENRPEAV---KSCEAL--AQKIEEFLEAHST---------DEFKDV 260
             +  K + SK  D+ +R EA    K  +AL  A+ +EE LEA             E +D+
Sbjct: 1464 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523

Query: 261  SATEP---QTAHSMTNRFNAMLKVFENQANMLERAVND-----------QVLLDAEYKQM 306
             +++    +  H +     A+    E     LE   ++           +V + A   Q 
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 307  QCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEK 366
            + D Q   E+      +LQ+   + +T+  + R ++A+    KK   K E   K +  + 
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK---KLEGDLKDLELQA 1640

Query: 367  EFKIKEDLDQVQKVARLEIENKVLQEQLKQA 397
            +  IK   + ++++ +L+ + K  Q +L+ A
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 59/316 (18%), Positives = 140/316 (44%), Gaps = 30/316 (9%)

Query: 116  HEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQ----NILE-------SLFKWFQWQ 164
            H  EE  L + D + +F   C  + A+   A +++Q     +++        L  W  W+
Sbjct: 784  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWR 843

Query: 165  ----VNQMEEISKDQTLLQAEPPKPDKT------VILNIAEIVRLVQRFEELKNRLKQRS 214
                V  + ++++ +  +QA+  +  KT          + E+ +   +  E KN L+++ 
Sbjct: 844  LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903

Query: 215  KSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNR 274
            ++  ++       +       +  E +  ++E  LE    D  + + A   + A  M + 
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLD- 961

Query: 275  FNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTK 334
               + +  E +    ++   ++V  +A+ K+++ +  ++ ++   L  E + L+++    
Sbjct: 962  ---LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

Query: 335  PTN--NRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQE 392
             TN     +KA    K K+K +S  SE ++  +KE K +++L+++++  +LE +     E
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR--KLEGDASDFHE 1076

Query: 393  QLKQALQEAEKAKHQL 408
            Q+     +  + K QL
Sbjct: 1077 QIADLQAQIAELKMQL 1092



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 47/203 (23%), Positives = 88/203 (43%), Gaps = 17/203 (8%)

Query: 141  AQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLV 200
            AQLEE L+EEQ  +E++    +    Q E++S +    ++   K +        +   L 
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1805

Query: 201  QRFEELKNRLKQRSKSSVKVMLSKTMDKENRPE--------AVKSCEALAQKIEEFLEAH 252
             +  E++  +K + KS++  + +K    E + E        A KS +   +K++E L   
Sbjct: 1806 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL-LQ 1864

Query: 253  STDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQL 312
              DE K     + Q       + NA +K  + Q   LE A  +   ++A  +++Q +   
Sbjct: 1865 VEDERKMAEQYKEQ-----AEKGNARVKQLKRQ---LEEAEEESQRINANRRKLQRELDE 1916

Query: 313  LSEEKLVLENELQKLKDKEKTKP 335
             +E    +  E+  LK K +  P
Sbjct: 1917 ATESNEAMGREVNALKSKLRGPP 1939



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 65/310 (20%), Positives = 129/310 (41%), Gaps = 36/310 (11%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA-EPPKPDKTVILNIAEIVRLVQR 202
            EEA+K+ +  L++  K FQ ++      S+D+    A E  K  K++  ++ ++   +  
Sbjct: 1648 EEAIKQLRK-LQAQMKDFQRELEDARA-SRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705

Query: 203  FEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSA 262
             E  + +     +   + + S    +    +  +  EA   ++EE LE            
Sbjct: 1706 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE----------- 1754

Query: 263  TEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLEN 322
             E     +M++R     +  E  +N  E A         E  + Q     L  +   L +
Sbjct: 1755 -EQGNMEAMSDRVRKATQQAEQLSN--ELATERSTAQKNESARQQ-----LERQNKELRS 1806

Query: 323  ELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK----KMSPEKEFKIKEDLDQVQ 378
            +L +++   K+K  +       K  + +++ + E  EK    K   +K+ K+KE L QV+
Sbjct: 1807 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1866

Query: 379  KVARLEIENKVLQE-------QLKQALQEAEKAKHQLNYFLNQEKLLKS-EGKTETTMQV 430
               ++  + K   E       QLK+ L+EAE+   ++N   N+ KL +  +  TE+   +
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN--ANRRKLQRELDEATESNEAM 1924

Query: 431  GNSQTKVKGE 440
            G     +K +
Sbjct: 1925 GREVNALKSK 1934



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 37/184 (20%), Positives = 88/184 (47%), Gaps = 20/184 (10%)

Query: 289  LERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQK----LKDKEKTKPTNNRTKKAV 344
            L++    Q   + E K+++     L+EEK +L+ +LQ       + E+ +      K+ +
Sbjct: 868  LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 927

Query: 345  KTV---------KKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIE-NKVLQEQL 394
            + +         +++D+G+   +E+K   ++   ++E L++ ++ AR +++  KV  E  
Sbjct: 928  EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAK 986

Query: 395  KQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKS 454
             + L++        N  L++E+ L  E  ++ T  +   +     E +KN+   K   +S
Sbjct: 987  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-----EKAKNLTKLKNKHES 1041

Query: 455  LVSD 458
            ++S+
Sbjct: 1042 MISE 1045



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 67/347 (19%), Positives = 149/347 (42%), Gaps = 47/347 (13%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRF 203
            EE ++ +++ L+   +  Q   N+++E+ +  + L  E     +     +     L    
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE----QLQAETELYAEA 913

Query: 204  EELKNRL---KQRSKSSVKVMLSKTMDKENRPEAVKS-CEALAQKIEEFLEAHSTDEF-K 258
            EE++ RL   KQ  +  +  M ++  ++E+R + +++  + +AQ++ +  E    +E  +
Sbjct: 914  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973

Query: 259  DVSATEPQTAHSMTNRFNAMLKVFENQAN-------MLERAVNDQVLLDAEYKQMQCDFQ 311
                 E  TA +   +    + V ++Q N       +LE  ++D     AE ++   +  
Sbjct: 974  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033

Query: 312  LLSEEKLVLENELQ-KLKDKEKTKPTNNRTKKAVK-----------------TVKKKDKG 353
             L  +   + +EL+ +LK +EK++    + K+ ++                    K    
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1093

Query: 354  KSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL---KQALQEAEKAKHQLNY 410
            K E+  +      + +I +  + ++K+  LE     LQE L   + A  +AEK K  L  
Sbjct: 1094 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG- 1152

Query: 411  FLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNI-----PLEKETR 452
                E+L   + + E T+    +Q +++ +  + +      L++ETR
Sbjct: 1153 ----EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 74/331 (22%), Positives = 139/331 (41%), Gaps = 41/331 (12%)

Query: 99   EETYGHCDQNGEEPFVKHEHEE----LSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNIL 154
            EE     DQ  EE   K   E     L++ + D       + S   A LEE  K  Q  +
Sbjct: 1343 EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKRFQKEI 1401

Query: 155  ESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRS 214
            E+L + ++ +    +++ K +  LQ E       +++++    +LV   E+ K R   + 
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDD----LVVDLDNQRQLVSNLEK-KQRKFDQL 1456

Query: 215  KSSVKVMLSKTMDKENRPEAV---KSCEAL--AQKIEEFLEAHST---------DEFKDV 260
             +  K + SK  D+ +R EA    K  +AL  A+ +EE LEA             E +D+
Sbjct: 1457 LAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516

Query: 261  SATEP---QTAHSMTNRFNAMLKVFENQANMLERAVND-----------QVLLDAEYKQM 306
             +++    +  H +     A+    E     LE   ++           +V + A   Q 
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576

Query: 307  QCDFQLLSEEKLVLENELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEK 366
            + D Q   E+      +LQ+   + +T+  + R ++A+    KK   K E   K +  + 
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK---KLEGDLKDLELQA 1633

Query: 367  EFKIKEDLDQVQKVARLEIENKVLQEQLKQA 397
            +  IK   + ++++ +L+ + K  Q +L+ A
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 59/316 (18%), Positives = 140/316 (44%), Gaps = 30/316 (9%)

Query: 116  HEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQ----NILE-------SLFKWFQWQ 164
            H  EE  L + D + +F   C  + A+   A +++Q     +++        L  W  W+
Sbjct: 777  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWR 836

Query: 165  ----VNQMEEISKDQTLLQAEPPKPDKT------VILNIAEIVRLVQRFEELKNRLKQRS 214
                V  + ++++ +  +QA+  +  KT          + E+ +   +  E KN L+++ 
Sbjct: 837  LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896

Query: 215  KSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNR 274
            ++  ++       +       +  E +  ++E  LE    D  + + A   + A  M + 
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEE-DRGQQLQAERKKMAQQMLD- 954

Query: 275  FNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEKTK 334
               + +  E +    ++   ++V  +A+ K+++ +  ++ ++   L  E + L+++    
Sbjct: 955  ---LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011

Query: 335  PTN--NRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQE 392
             TN     +KA    K K+K +S  SE ++  +KE K +++L+++++  +LE +     E
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR--KLEGDASDFHE 1069

Query: 393  QLKQALQEAEKAKHQL 408
            Q+     +  + K QL
Sbjct: 1070 QIADLQAQIAELKMQL 1085



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 47/203 (23%), Positives = 88/203 (43%), Gaps = 17/203 (8%)

Query: 141  AQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLV 200
            AQLEE L+EEQ  +E++    +    Q E++S +    ++   K +        +   L 
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELR 1798

Query: 201  QRFEELKNRLKQRSKSSVKVMLSKTMDKENRPE--------AVKSCEALAQKIEEFLEAH 252
             +  E++  +K + KS++  + +K    E + E        A KS +   +K++E L   
Sbjct: 1799 SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL-LQ 1857

Query: 253  STDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQL 312
              DE K     + Q       + NA +K  + Q   LE A  +   ++A  +++Q +   
Sbjct: 1858 VEDERKMAEQYKEQ-----AEKGNARVKQLKRQ---LEEAEEESQRINANRRKLQRELDE 1909

Query: 313  LSEEKLVLENELQKLKDKEKTKP 335
             +E    +  E+  LK K +  P
Sbjct: 1910 ATESNEAMGREVNALKSKLRGPP 1932



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 65/310 (20%), Positives = 129/310 (41%), Gaps = 36/310 (11%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQA-EPPKPDKTVILNIAEIVRLVQR 202
            EEA+K+ +  L++  K FQ ++      S+D+    A E  K  K++  ++ ++   +  
Sbjct: 1641 EEAIKQLRK-LQAQMKDFQRELEDARA-SRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698

Query: 203  FEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSA 262
             E  + +     +   + + S    +    +  +  EA   ++EE LE            
Sbjct: 1699 AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE----------- 1747

Query: 263  TEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLEN 322
             E     +M++R     +  E  +N  E A         E  + Q     L  +   L +
Sbjct: 1748 -EQGNMEAMSDRVRKATQQAEQLSN--ELATERSTAQKNESARQQ-----LERQNKELRS 1799

Query: 323  ELQKLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEK----KMSPEKEFKIKEDLDQVQ 378
            +L +++   K+K  +       K  + +++ + E  EK    K   +K+ K+KE L QV+
Sbjct: 1800 KLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVE 1859

Query: 379  KVARLEIENKVLQE-------QLKQALQEAEKAKHQLNYFLNQEKLLKS-EGKTETTMQV 430
               ++  + K   E       QLK+ L+EAE+   ++N   N+ KL +  +  TE+   +
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN--ANRRKLQRELDEATESNEAM 1917

Query: 431  GNSQTKVKGE 440
            G     +K +
Sbjct: 1918 GREVNALKSK 1927



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 37/184 (20%), Positives = 88/184 (47%), Gaps = 20/184 (10%)

Query: 289  LERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQK----LKDKEKTKPTNNRTKKAV 344
            L++    Q   + E K+++     L+EEK +L+ +LQ       + E+ +      K+ +
Sbjct: 861  LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL 920

Query: 345  KTV---------KKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIE-NKVLQEQL 394
            + +         +++D+G+   +E+K   ++   ++E L++ ++ AR +++  KV  E  
Sbjct: 921  EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQLEKVTAEAK 979

Query: 395  KQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKS 454
             + L++        N  L++E+ L  E  ++ T  +   +     E +KN+   K   +S
Sbjct: 980  IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE-----EKAKNLTKLKNKHES 1034

Query: 455  LVSD 458
            ++S+
Sbjct: 1035 MISE 1038



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 67/347 (19%), Positives = 149/347 (42%), Gaps = 47/347 (13%)

Query: 144  EEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRF 203
            EE ++ +++ L+   +  Q   N+++E+ +  + L  E     +     +     L    
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE----QLQAETELYAEA 906

Query: 204  EELKNRL---KQRSKSSVKVMLSKTMDKENRPEAVKS-CEALAQKIEEFLEAHSTDEF-K 258
            EE++ RL   KQ  +  +  M ++  ++E+R + +++  + +AQ++ +  E    +E  +
Sbjct: 907  EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966

Query: 259  DVSATEPQTAHSMTNRFNAMLKVFENQAN-------MLERAVNDQVLLDAEYKQMQCDFQ 311
                 E  TA +   +    + V ++Q N       +LE  ++D     AE ++   +  
Sbjct: 967  QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026

Query: 312  LLSEEKLVLENELQ-KLKDKEKTKPTNNRTKKAVK-----------------TVKKKDKG 353
             L  +   + +EL+ +LK +EK++    + K+ ++                    K    
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLA 1086

Query: 354  KSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQL---KQALQEAEKAKHQLNY 410
            K E+  +      + +I +  + ++K+  LE     LQE L   + A  +AEK K  L  
Sbjct: 1087 KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG- 1145

Query: 411  FLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNI-----PLEKETR 452
                E+L   + + E T+    +Q +++ +  + +      L++ETR
Sbjct: 1146 ----EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 80/390 (20%), Positives = 166/390 (42%), Gaps = 31/390 (7%)

Query: 114  VKHEHEELSLSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISK 173
            ++ E  EL + + DDM S +   S+  + +E   +     +E  F   + +  Q  ++  
Sbjct: 1221 LEKEKSELKMEI-DDMASNIEALSKSKSNIERTCRT----VEDQFSEIKAKDEQQTQLIH 1275

Query: 174  DQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPE 233
            D  + +A     +  +   + E   L+ +  + K  L Q+ +   + M  +T  K     
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAH 1335

Query: 234  AVKS----CEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANML 289
            A++S    C+ L ++ EE  EA +  + + +S    + A   T      ++  E      
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQ-RALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 290  ERAVNDQVLLDAEYKQMQCDFQLLSEEKLV--LENELQKL-KDKEKT--------KPTNN 338
            ++    Q L +AE      + +  S EK    L+ E++ L +D E++        K   N
Sbjct: 1395 KKLA--QRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN 1452

Query: 339  RTKKAVKTVKKKDKGKSE----DSEKKMSPEKEFKIKEDLDQV-QKVARLEIENKVLQEQ 393
              K   +  +K D+ ++E      E +    + FK++   ++V  ++  L  ENK LQE+
Sbjct: 1453 FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEE 1512

Query: 394  LKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRK 453
            +    ++  +    L      +KL++ E K++  + +   +  ++ E+SK + ++ E   
Sbjct: 1513 ISDLTEQIAETGKNLQEAEKTKKLVEQE-KSDLQVALEEVEGSLEHEESKILRVQLEL-- 1569

Query: 454  SLVSDSGGQRTSDKIQEYPQITAQSGRLIE 483
            S V     ++  +K +E  Q+   S R  E
Sbjct: 1570 SQVKSELDRKVIEKDEEIEQLKRNSQRAAE 1599



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 42/201 (20%), Positives = 92/201 (45%), Gaps = 15/201 (7%)

Query: 137  SQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVILNIAEI 196
            +Q  A++E +++E +N  E   K         EE+ K+Q    A   +  K +   + ++
Sbjct: 1739 AQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKNLEQTVKDL 1797

Query: 197  VRLVQRFEE--LKNRLKQRSKSSVKVM-LSKTMDKENR--PEAVKSCEALAQKIEEFLEA 251
               +   E+  LK   KQ  K   +V  L   +D E +   EA+K      +K++E +  
Sbjct: 1798 QHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKE-MTY 1856

Query: 252  HSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQ 311
             + ++ K++   +      + ++  A +K ++ QA   E   N Q+   +  +++Q + +
Sbjct: 1857 QAEEDHKNILRLQ-----DLVDKLQAKVKSYKRQAEEAEEQANTQL---SRCRRVQHELE 1908

Query: 312  LLSEEKLVLENELQKLKDKEK 332
              +E   + E+++ KL+ K +
Sbjct: 1909 EAAERADIAESQVNKLRAKSR 1929



 Score = 37.0 bits (84), Expect = 0.040
 Identities = 50/240 (20%), Positives = 106/240 (44%), Gaps = 35/240 (14%)

Query: 199  LVQRFEELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFK 258
            L++  EE+K  L+Q  ++  ++   + +D  +R + + S        ++ LEA       
Sbjct: 1685 LLEELEEMKVALEQTERTR-RLSEQELLDASDRVQLLHSQNTSLINTKKKLEA------- 1736

Query: 259  DVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKL 318
            D++  + +  +S+    NA  K         ++A+ D  ++  E K+ Q     L   K 
Sbjct: 1737 DIAQCQAEVENSIQESRNAEEKA--------KKAITDAAMMAEELKKEQDTSAHLERMKK 1788

Query: 319  VLENELQKLKD-------------KEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPE 365
             LE  ++ L+              K++ +   NR ++    +  + K  +E    K + +
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAE--ALKGAHK 1846

Query: 366  KEFKIKEDLDQVQK----VARLEIENKVLQEQLKQALQEAEKAKHQLNYFLNQEKLLKSE 421
             E K+KE   Q ++    + RL+     LQ ++K   ++AE+A+ Q N  L++ + ++ E
Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHE 1906



 Score = 32.3 bits (72), Expect = 0.99
 Identities = 32/106 (30%), Positives = 56/106 (52%), Gaps = 10/106 (9%)

Query: 354 KSEDSEKKMSPEKEFKIKEDLDQV-QKVARLEIENKVLQEQLKQALQEAEKAKHQLNYFL 412
           KS ++EK+M+      +KED ++  +++AR E   K L+E++   LQ  EK   QL    
Sbjct: 845 KSAEAEKEMAT-----MKEDFERTKEELARSEARRKELEEKMVSLLQ--EKNDLQLQVQS 897

Query: 413 NQEKLLKSEGKTETTMQVG-NSQTKVKGEDSKNIPLEKETRKSLVS 457
             E L+ +E + E  ++     + KVK E ++ +  E+E    LV+
Sbjct: 898 ETENLMDAEERCEGLIKSKILLEAKVK-ELTERLEEEEEMNSELVA 942


>gi|87299628 biorientation of chromosomes in cell division 1-like
           [Homo sapiens]
          Length = 3051

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 78/346 (22%), Positives = 154/346 (44%), Gaps = 36/346 (10%)

Query: 155 ESLFKWFQWQVNQMEEISKDQTLLQAEPP--KPDKTVILNIAEIVRLVQRFEELKNRLKQ 212
           ES  K  + +  +++E+ K++ +L+ +    K  K    N+ E  +  Q++EE      +
Sbjct: 543 ESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLK 602

Query: 213 RSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMT 272
            S+   K  +S + + ++   A       A+++ E L  H  DE K+ S  E +  H   
Sbjct: 603 TSEHCEKEKISSSKELKH-VHAKSEPSKPARRLSESL--HVVDENKNESKLERE--HKRR 657

Query: 273 NRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDKEK 332
                +++  + + +   R V  QV      ++ +   +   ++K  L+NE    KD  +
Sbjct: 658 TSTPVIMEGVQEETDT--RDVKRQV------ERSEICTEEPQKQKSTLKNEKHLKKDDSE 709

Query: 333 TKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFK--------IKEDLDQVQKVARLE 384
           T    +  KK VK+ K+K + +   SE K+S + ++K         + +L   +K  ++E
Sbjct: 710 TPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVE 769

Query: 385 --IENKVLQEQLKQALQEAEKAKHQLNYFLNQEKL--LKSEGKTETTMQVGNSQTKVKGE 440
             I+ +  Q +L    +   K+KH+     N+ KL  L  +GK  +   +   +   K  
Sbjct: 770 ENIQKQSQQTKLSSDDKTERKSKHR-----NERKLSVLGKDGKPVSEYIIKTDENVRKEN 824

Query: 441 DSKNIPLEKETRKSLVSDSGGQRTSD-KIQEYPQITAQSGRLIEKR 485
           + K   L  E  K   ++   +R+SD KIQ+    + Q G  +++R
Sbjct: 825 NKKERRLSAEKTK---AEHKSRRSSDSKIQKDSLGSKQHGITLQRR 867



 Score = 37.4 bits (85), Expect = 0.031
 Identities = 56/235 (23%), Positives = 97/235 (41%), Gaps = 30/235 (12%)

Query: 216 SSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRF 275
           SSV      + +++   E V S       +EE       +E    + T+ QT+ S   + 
Sbjct: 409 SSVHTSDLSSFEEDTEEEVVTS-----DSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKT 463

Query: 276 NAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSE-EKLVLENELQKLKDKEKTK 334
            ++   + ++  +  +  +D    D E    Q    +  E E+ +L  ++ + K +EK K
Sbjct: 464 KSVRHAYVHKPYLYSKYYSDS---DDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRK 520

Query: 335 PTNNRTKKAVKTVKKKDKGKS----EDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVL 390
               +TK +    K K +G+S    E+S  K    K  +IKE L           E KVL
Sbjct: 521 QKAEKTKSS----KTKGQGRSSVDLEESSTKSLEPKAARIKEVLK----------ERKVL 566

Query: 391 QEQLKQALQEAEKAKHQLNYFLNQEKLLKSEGKTETTMQVGNSQTKVKGEDSKNI 445
           ++  K AL +  K K   N   N +K  + E  ++ T++      K K   SK +
Sbjct: 567 EK--KVALSKKRK-KDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKEL 618



 Score = 33.9 bits (76), Expect = 0.34
 Identities = 56/282 (19%), Positives = 113/282 (40%), Gaps = 50/282 (17%)

Query: 204 EELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSC--------------------EALAQ 243
           EE+KN  K+ +     ++L+K + +E+  +  KS                     E   +
Sbjct: 288 EEIKNYTKEHNNL---ILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEK 344

Query: 244 KIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEY 303
           K +   ++  T + KD    E Q             +   N+A  +E    D  L+D++ 
Sbjct: 345 KFDHSKKSEDTQKVKD----EKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDV 400

Query: 304 KQMQCDFQLLSEEKLVLENELQKLK-DKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKM 362
             +  D  + S    V  ++L   + D E+   T++  ++   T   ++K K   ++ + 
Sbjct: 401 DGLT-DITVSS----VHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQT 455

Query: 363 SPEKEFKIKEDLDQVQKVARL------EIENKVLQEQLKQAL---QEAEKAKHQLNYFLN 413
           S   E K K           L      + ++++  EQ +Q++   +E    + Q+N    
Sbjct: 456 SDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKL 515

Query: 414 QEKLLKSEGKTETTMQVGNSQTKVKGEDSKNIPLEKETRKSL 455
           +EK  +   KT++        +K KG+   ++ LE+ + KSL
Sbjct: 516 EEKRKQKAEKTKS--------SKTKGQGRSSVDLEESSTKSL 549



 Score = 30.4 bits (67), Expect = 3.8
 Identities = 60/285 (21%), Positives = 117/285 (41%), Gaps = 44/285 (15%)

Query: 206  LKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEP 265
            L+ +L  +SKS  +    K ++ E +  A K  +A   K ++       D  K   +   
Sbjct: 904  LEEKLVLKSKSKTQGKQVKVVETELQEGATK--QATTPKPDKEKNTEENDSEKQRKSKVE 961

Query: 266  QTAHSMTNRFNAMLKVFENQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQ 325
                  T     +L+   + A+  ++  + +  L    ++ + D    S     LE   +
Sbjct: 962  DKPFEETG-VEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTR---LE---R 1014

Query: 326  KLKDKEKTKPTNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKEDLDQVQ-KVARLE 384
            KL D  K++      K + K +KKKD+ KS+D + K       K + +   ++ K++R  
Sbjct: 1015 KLSDGHKSRSL----KHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRL 1070

Query: 385  IENK---VLQEQLK---------------QALQEAEKAKHQLNYFLNQEKL-LKSEGKTE 425
             EN+   + QE  K                +LQ  +K+   +     QE + + SE   E
Sbjct: 1071 CENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKS-GDMTLIPEQEPMEIDSEPGVE 1129

Query: 426  TTMQVGNSQTKVKGEDSKNIPLEKETRKSLVSDSGGQRTSDKIQE 470
               +V  +Q      D++N      +++ + S++  Q+TS  +Q+
Sbjct: 1130 NVFEVSKTQ------DNRN----NNSQQDIDSENMKQKTSATVQK 1164


>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
           sapiens]
          Length = 796

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 89/399 (22%), Positives = 170/399 (42%), Gaps = 59/399 (14%)

Query: 80  EDEMIGKIIKHLKM-------VVSTLEETYGHCDQNGEEPFVKHEHEELSLSVGDD-MNS 131
           E  + GK I  LK         +S L++T         +PF+  +   +S +     +NS
Sbjct: 323 EIPITGKNITDLKFHSRVPRYTLSFLDQTKHEMKDKERQPFLVKQGSIISENEKTSKVNS 382

Query: 132 FLTYCSQFAAQLEEALKEEQNILESLFKWFQWQVNQMEEISKDQTLLQAEPPKPDKTVIL 191
               C      L+  LKE   I + + +     +N   ++               K +I 
Sbjct: 383 VTEQCVAKIQYLQNYLKESVQIQKKVMELESENLNLKSKM---------------KPLIF 427

Query: 192 NIAEIVRLVQRFE-ELKNRLKQRSKSSVKVMLSKTMDKENRPEAVKSCEALAQKIEEFLE 250
               +++ V+ +E +LKN +++  KS+++  LSKT  +E   E +K  + +  K      
Sbjct: 428 TTQSLIQKVETYEKQLKNLVEE--KSTIQSKLSKT--EEYSKECLKEFKKIISKYNVLQG 483

Query: 251 AHSTDEFKDVSAT-EPQTA-------HSMTNRFNAMLKVFENQANMLE---RAVNDQVLL 299
            + T E K++  + E Q          S  ++  + + +  N+ N +     A+   +LL
Sbjct: 484 QNKTLEEKNIQLSLEKQQMMEALDQLKSKEHKTQSDMAIVNNENNRMSIEMEAMKTNILL 543

Query: 300 DAEYKQM--QCDFQLLSEEKLVLENELQK-------LKDKEKTKPTNNRTKKAVKTVKKK 350
             + K+M  +   QLL +EK  L NEL++       LK+KE+   T   T   +    K 
Sbjct: 544 IQDEKEMLEKKTHQLL-KEKSSLGNELKESQLEIIQLKEKERLAKTEQETLLQIIETVKD 602

Query: 351 DKGKSEDSEKKMSPEKEFKIKEDLDQVQKVARLEIENKVLQEQLKQALQEAEKAKHQLNY 410
           +K   E + ++ +  ++  ++ +++ +Q       EN    +++K A  EA   K+ L+ 
Sbjct: 603 EKLNLETTLQESTAARQI-MEREIENIQTYQSTAEEN--FLQEIKNAKSEASIYKNSLSE 659

Query: 411 FLNQ-EKLLKSEGKTETTMQV------GNSQTKVKGEDS 442
              + E L K   +T+T  Q+       +SQ  +K E+S
Sbjct: 660 IGKECEMLSKMVMETKTDNQILKEELKKHSQENIKFENS 698



 Score = 30.0 bits (66), Expect = 4.9
 Identities = 63/277 (22%), Positives = 109/277 (39%), Gaps = 42/277 (15%)

Query: 107 QNGEEPFVKHEHEELS--LSVGDDMNSFLTYCSQFAAQLEEALKEEQNILESLFKWFQWQ 164
           Q+ +E   K  H+ L    S+G+++           +QLE    +E+   E L K  Q  
Sbjct: 545 QDEKEMLEKKTHQLLKEKSSLGNELKE---------SQLEIIQLKEK---ERLAKTEQET 592

Query: 165 VNQMEEISKDQTLLQAEPPKPDKTVILNIAEIVRLVQRFEELKNRLKQRSKSSVKVMLSK 224
           + Q+ E  KD+ L   E    + T    I E  R ++  +  ++  ++     +K   S+
Sbjct: 593 LLQIIETVKDEKL-NLETTLQESTAARQIME--REIENIQTYQSTAEENFLQEIKNAKSE 649

Query: 225 -TMDKENRPEAVKSCEALAQKIEEFLEAHSTDEFKDVSATEPQTAHSMTNRFNAMLKVFE 283
            ++ K +  E  K CE L++ + E      TD   +    E    HS  N     +K FE
Sbjct: 650 ASIYKNSLSEIGKECEMLSKMVMET----KTD---NQILKEELKKHSQEN-----IK-FE 696

Query: 284 NQANMLERAVNDQVLLDAEYKQMQCDFQLLSEEKLVLENELQKLKDK--------EKTKP 335
           N    + R   D++LL+   + ++ +   L  E   L+ E   L DK         KT  
Sbjct: 697 NS---ISRLTEDKILLENYVRSIENERDTLEFEMRHLQREYLSLSDKICNQHNDPSKTTY 753

Query: 336 TNNRTKKAVKTVKKKDKGKSEDSEKKMSPEKEFKIKE 372
            + R K        +D    +        +  FK+K+
Sbjct: 754 ISRREKFHFDNYTHEDTSSPQSRPLASDLKGYFKVKD 790


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.336 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,510,786
Number of Sequences: 37866
Number of extensions: 803054
Number of successful extensions: 7518
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 823
Number of HSP's that attempted gapping in prelim test: 4545
Number of HSP's gapped (non-prelim): 2606
length of query: 486
length of database: 18,247,518
effective HSP length: 106
effective length of query: 380
effective length of database: 14,233,722
effective search space: 5408814360
effective search space used: 5408814360
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.