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Search of human proteins with 13699811
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13699811 WHSC1L1 protein isoform long [Homo sapiens]
(1437 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13699811 WHSC1L1 protein isoform long [Homo sapiens] 2989 0.0
gi|13699813 WHSC1L1 protein isoform short [Homo sapiens] 1244 0.0
gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 1177 0.0
gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 1177 0.0
gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 1177 0.0
gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isofor... 1177 0.0
gi|27477095 nuclear receptor binding SET domain protein 1 isofor... 958 0.0
gi|19923586 nuclear receptor binding SET domain protein 1 isofor... 958 0.0
gi|19913356 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 222 2e-57
gi|6594683 Wolf-Hirschhorn syndrome candidate 1 protein isoform ... 222 2e-57
gi|197313748 SET domain containing 2 [Homo sapiens] 194 4e-49
gi|110349788 absent, small, or homeotic 1-like [Homo sapiens] 188 3e-47
gi|19923202 enhancer of zeste homolog 1 [Homo sapiens] 100 2e-20
gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens] 96 2e-19
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens] 94 7e-19
gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens] 94 7e-19
gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens] 94 7e-19
gi|210032580 SET domain containing 1B [Homo sapiens] 92 4e-18
gi|194306650 SET domain and mariner transposase fusion [Homo sap... 91 8e-18
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 85 6e-16
gi|55741677 SET domain containing 1A [Homo sapiens] 82 3e-15
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 82 3e-15
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 82 3e-15
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 81 8e-15
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 78 7e-14
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 77 9e-14
gi|4504191 mutS homolog 6 [Homo sapiens] 76 3e-13
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s... 75 3e-13
gi|24308089 chromodomain helicase DNA binding protein 5 [Homo sa... 67 1e-10
gi|51599156 chromodomain helicase DNA binding protein 4 [Homo sa... 64 1e-09
>gi|13699811 WHSC1L1 protein isoform long [Homo sapiens]
Length = 1437
Score = 2989 bits (7748), Expect = 0.0
Identities = 1437/1437 (100%), Positives = 1437/1437 (100%)
Query: 1 MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYP 60
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYP
Sbjct: 1 MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYP 60
Query: 61 ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR 120
ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR
Sbjct: 61 ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR 120
Query: 121 PHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV 180
PHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
Sbjct: 121 PHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV 180
Query: 181 QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPRE 240
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPRE
Sbjct: 181 QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPRE 240
Query: 241 EPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI 300
EPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI
Sbjct: 241 EPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI 300
Query: 301 NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR 360
NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
Sbjct: 301 NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR 360
Query: 361 PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR 420
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR
Sbjct: 361 PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR 420
Query: 421 RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLP 480
RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLP
Sbjct: 421 RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLP 480
Query: 481 ASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ 540
ASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
Sbjct: 481 ASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ 540
Query: 541 DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIK 600
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIK
Sbjct: 541 DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIK 600
Query: 601 KEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSD 660
KEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSD
Sbjct: 601 KEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSD 660
Query: 661 LQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE 720
LQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE
Sbjct: 661 LQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGE 720
Query: 721 CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVR 780
CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVR
Sbjct: 721 CCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVR 780
Query: 781 KFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLV 840
KFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLV
Sbjct: 781 KFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLV 840
Query: 841 SSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAE 900
SSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAE
Sbjct: 841 SSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAE 900
Query: 901 LMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHY 960
LMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHY
Sbjct: 901 LMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHY 960
Query: 961 KQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYV 1020
KQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYV
Sbjct: 961 KQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYV 1020
Query: 1021 EGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANK 1080
EGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANK
Sbjct: 1021 EGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANK 1080
Query: 1081 VIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFT 1140
VIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFT
Sbjct: 1081 VIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFT 1140
Query: 1141 KRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFY 1200
KRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFY
Sbjct: 1141 KRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFY 1200
Query: 1201 MLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFN 1260
MLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFN
Sbjct: 1201 MLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFN 1260
Query: 1261 YNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMH 1320
YNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMH
Sbjct: 1261 YNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMH 1320
Query: 1321 EDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEF 1380
EDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEF
Sbjct: 1321 EDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEF 1380
Query: 1381 CPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE 1437
CPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE
Sbjct: 1381 CPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE 1437
>gi|13699813 WHSC1L1 protein isoform short [Homo sapiens]
Length = 645
Score = 1244 bits (3220), Expect = 0.0
Identities = 619/622 (99%), Positives = 622/622 (100%)
Query: 1 MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYP 60
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYP
Sbjct: 1 MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYP 60
Query: 61 ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR 120
ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR
Sbjct: 61 ATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTR 120
Query: 121 PHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV 180
PHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV
Sbjct: 121 PHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEV 180
Query: 181 QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPRE 240
QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPRE
Sbjct: 181 QASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPRE 240
Query: 241 EPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI 300
EPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI
Sbjct: 241 EPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI 300
Query: 301 NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR 360
NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR
Sbjct: 301 NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR 360
Query: 361 PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR 420
PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR
Sbjct: 361 PQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTR 420
Query: 421 RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLP 480
RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLP
Sbjct: 421 RPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLP 480
Query: 481 ASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ 540
ASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ
Sbjct: 481 ASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQ 540
Query: 541 DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIK 600
DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIK
Sbjct: 541 DRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIK 600
Query: 601 KEQVETVPQATVKTGLQKGASE 622
KEQVETVPQATVKTGLQKG+++
Sbjct: 601 KEQVETVPQATVKTGLQKGSAD 622
Score = 43.9 bits (102), Expect = 0.001
Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Query: 951 DCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSH-DYY 1009
+ G K +VW K+G Y WWP + + + ++ + ++ V FF + +
Sbjct: 261 EVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERA 320
Query: 1010 WVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRE 1056
WVH+ RV Y +G K + E K E+ ++ ++ + QRE
Sbjct: 321 WVHEKRVREY-KGHKQYEELLAEATKQASNHSEK--QKIRKPRPQRE 364
>gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 1177 bits (3045), Expect = 0.0
Identities = 617/1308 (47%), Positives = 799/1308 (61%), Gaps = 129/1308 (9%)
Query: 140 PQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESR-KEKRK 198
P P K GSPEIKLKITKT NG+ LFESS+CGD +V SE K E++ + RK
Sbjct: 111 PPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRK 170
Query: 199 KSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVP 258
+S K+DS + + ++ + S+K + P KE P
Sbjct: 171 RSIKYDSLLEQGLVEAALVS-----------KISSPSDK--KIPAKKESCP--------- 208
Query: 259 TTEVSTG------VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN--TRGAREYHV 310
+TG +K+ VGDLVWSKV YPWWPCMVS+DP L +TK+ + AR+YHV
Sbjct: 209 ----NTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHV 264
Query: 311 QFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDI 370
QFF + PERAW+ EK + ++G Q+E+L E+ KQA +EK K+ KP + RAQW++
Sbjct: 265 QFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEM 324
Query: 371 GIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQP 430
GI AE+A M+ EER ++TF+Y+ Q AK++ + + + V
Sbjct: 325 GIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAA 384
Query: 431 EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPV--KIAWKTAAA--RKSLPASITMH 486
E N V + RR ++ ++ E P + KTA A R+ + +
Sbjct: 385 E--NPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRK 442
Query: 487 KGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYS-TKGIGNKTEISVRGQDRLII 545
K ++ + + VF ++ D+ V G + E +R Q L+
Sbjct: 443 KTTVSMPRSRKGDAASQFLVFCQKHR-------DEVVAEHPDASGEEIEELLRSQWSLLS 495
Query: 546 STPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKS-TEVVPKKKIKKEQV 604
R V+ +A S G+V K++ + R + +E + E P+K+++ ++
Sbjct: 496 EKQRARYNTKFALVAPVQAEEDS-GNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKH 554
Query: 605 -----ETVPQATVKTGLQKG------------ASEISDSCKPLKKRSRASTDVEMTSSAY 647
+T+ T +T K +SD+CKPLKKR+RAST
Sbjct: 555 SLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFS 614
Query: 648 RDTSDSDSRGLSDLQVGFGKQV-DSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQI 706
+ +S S S +++ G + +SP +AD ++V S+ S S RG +KK+ VCQ+
Sbjct: 615 KSSSPSASLTENEVSDSPGDEPSESPYESADETQTEV-SVSSKKSERGV-TAKKEYVCQL 672
Query: 707 CESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCS 766
CE G SL+ CEG CC FHL CLGL+ P+ +F C EC +G H CF CK S DVKRC
Sbjct: 673 CEKPG-SLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCV 731
Query: 767 VGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIH-KASKGRMMRCLRCPVA 825
V CGKFYHEACV+K+P +FES+GFRCP H C +C + + SKG+MMRC+RCPVA
Sbjct: 732 VTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVA 791
Query: 826 YHSGDACIAAGSMLVSSYILICSNH---SKRSSNSSAVNVGFCFVCARGLIVQDHSDPMF 882
YHSGDAC+AAG +++S +IC+ H K + + VNV +CFV
Sbjct: 792 YHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFV--------------- 836
Query: 883 SSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEM 942
C KGG LLCCESCPA+FHP+CL+IEM
Sbjct: 837 ----------------------------------CSKGGSLLCCESCPAAFHPDCLNIEM 862
Query: 943 PEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFF 1002
P+G W CNDC+AGKKLH++ I+WVKLGNYRWWPAE+C+P++VP NIQ +KH++G+FPVFF
Sbjct: 863 PDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFF 922
Query: 1003 FGSHDYYWVHQGRVFPYVEGDK-SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL 1061
FGS DYYW HQ RVFPY+EGD+ S +G I + FK AL+EA RF+E+K QRE++E
Sbjct: 923 FGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQ 982
Query: 1062 EIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQY 1121
E E RKPPPYKHIK NK GKVQI AD+SEIP+CNCKP DENPCG +SECLNRML +
Sbjct: 983 ESE---RKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMF 1039
Query: 1122 ECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE 1181
ECHPQVCPAG+ CQNQCFTKR YP+ +IIKT+ +GWGL KR I+KGEFVNEYVGELIDE
Sbjct: 1040 ECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDE 1099
Query: 1182 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV 1241
EEC RIK AHEN +T+FYMLT+ KDRIIDAGPKGNYSRFMNHSC PNCET KWTVNGD
Sbjct: 1100 EECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDT 1159
Query: 1242 RVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAK 1301
RVGLFA+CDIPAG ELTFNYNLDCLGN +T C CGA NCSGFLG RPK++ ++EEK K
Sbjct: 1160 RVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGK 1219
Query: 1302 NAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE 1361
K K +RR+ K E K+ ED CF+CGDGG+LV+CD+K C KAYHL CL L + P+GKWE
Sbjct: 1220 KTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWE 1279
Query: 1362 CPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409
CPWH CD C + SFC CP+SFCK+H+ G +GR C EHD
Sbjct: 1280 CPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHD 1327
Score = 38.5 bits (88), Expect = 0.047
Identities = 35/121 (28%), Positives = 45/121 (37%), Gaps = 20/121 (16%)
Query: 693 RGTGMSKKDTVCQICESSGDSLIPCEGE-CCKHFHLECLGLASLPDSKFICMECKTGQHP 751
+G G + + C C G L+ C+ + C K +HL CLGL P K+ C P
Sbjct: 1231 KGEGKRQSEDECFRC-GDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWEC--------P 1281
Query: 752 CFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKA 811
C V GK S C C F + F C S C E D+ A
Sbjct: 1282 WHHCDVCGKP----STSFC-----HLCPNSFCKEHQDGTAFSCTPDGRSYC-CEHDLGAA 1331
Query: 812 S 812
S
Sbjct: 1332 S 1332
>gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 1177 bits (3045), Expect = 0.0
Identities = 617/1308 (47%), Positives = 799/1308 (61%), Gaps = 129/1308 (9%)
Query: 140 PQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESR-KEKRK 198
P P K GSPEIKLKITKT NG+ LFESS+CGD +V SE K E++ + RK
Sbjct: 111 PPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRK 170
Query: 199 KSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVP 258
+S K+DS + + ++ + S+K + P KE P
Sbjct: 171 RSIKYDSLLEQGLVEAALVS-----------KISSPSDK--KIPAKKESCP--------- 208
Query: 259 TTEVSTG------VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN--TRGAREYHV 310
+TG +K+ VGDLVWSKV YPWWPCMVS+DP L +TK+ + AR+YHV
Sbjct: 209 ----NTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHV 264
Query: 311 QFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDI 370
QFF + PERAW+ EK + ++G Q+E+L E+ KQA +EK K+ KP + RAQW++
Sbjct: 265 QFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEM 324
Query: 371 GIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQP 430
GI AE+A M+ EER ++TF+Y+ Q AK++ + + + V
Sbjct: 325 GIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAA 384
Query: 431 EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPV--KIAWKTAAA--RKSLPASITMH 486
E N V + RR ++ ++ E P + KTA A R+ + +
Sbjct: 385 E--NPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRK 442
Query: 487 KGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYS-TKGIGNKTEISVRGQDRLII 545
K ++ + + VF ++ D+ V G + E +R Q L+
Sbjct: 443 KTTVSMPRSRKGDAASQFLVFCQKHR-------DEVVAEHPDASGEEIEELLRSQWSLLS 495
Query: 546 STPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKS-TEVVPKKKIKKEQV 604
R V+ +A S G+V K++ + R + +E + E P+K+++ ++
Sbjct: 496 EKQRARYNTKFALVAPVQAEEDS-GNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKH 554
Query: 605 -----ETVPQATVKTGLQKG------------ASEISDSCKPLKKRSRASTDVEMTSSAY 647
+T+ T +T K +SD+CKPLKKR+RAST
Sbjct: 555 SLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFS 614
Query: 648 RDTSDSDSRGLSDLQVGFGKQV-DSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQI 706
+ +S S S +++ G + +SP +AD ++V S+ S S RG +KK+ VCQ+
Sbjct: 615 KSSSPSASLTENEVSDSPGDEPSESPYESADETQTEV-SVSSKKSERGV-TAKKEYVCQL 672
Query: 707 CESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCS 766
CE G SL+ CEG CC FHL CLGL+ P+ +F C EC +G H CF CK S DVKRC
Sbjct: 673 CEKPG-SLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCV 731
Query: 767 VGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIH-KASKGRMMRCLRCPVA 825
V CGKFYHEACV+K+P +FES+GFRCP H C +C + + SKG+MMRC+RCPVA
Sbjct: 732 VTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVA 791
Query: 826 YHSGDACIAAGSMLVSSYILICSNH---SKRSSNSSAVNVGFCFVCARGLIVQDHSDPMF 882
YHSGDAC+AAG +++S +IC+ H K + + VNV +CFV
Sbjct: 792 YHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFV--------------- 836
Query: 883 SSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEM 942
C KGG LLCCESCPA+FHP+CL+IEM
Sbjct: 837 ----------------------------------CSKGGSLLCCESCPAAFHPDCLNIEM 862
Query: 943 PEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFF 1002
P+G W CNDC+AGKKLH++ I+WVKLGNYRWWPAE+C+P++VP NIQ +KH++G+FPVFF
Sbjct: 863 PDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFF 922
Query: 1003 FGSHDYYWVHQGRVFPYVEGDK-SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL 1061
FGS DYYW HQ RVFPY+EGD+ S +G I + FK AL+EA RF+E+K QRE++E
Sbjct: 923 FGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQ 982
Query: 1062 EIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQY 1121
E E RKPPPYKHIK NK GKVQI AD+SEIP+CNCKP DENPCG +SECLNRML +
Sbjct: 983 ESE---RKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMF 1039
Query: 1122 ECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE 1181
ECHPQVCPAG+ CQNQCFTKR YP+ +IIKT+ +GWGL KR I+KGEFVNEYVGELIDE
Sbjct: 1040 ECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDE 1099
Query: 1182 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV 1241
EEC RIK AHEN +T+FYMLT+ KDRIIDAGPKGNYSRFMNHSC PNCET KWTVNGD
Sbjct: 1100 EECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDT 1159
Query: 1242 RVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAK 1301
RVGLFA+CDIPAG ELTFNYNLDCLGN +T C CGA NCSGFLG RPK++ ++EEK K
Sbjct: 1160 RVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGK 1219
Query: 1302 NAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE 1361
K K +RR+ K E K+ ED CF+CGDGG+LV+CD+K C KAYHL CL L + P+GKWE
Sbjct: 1220 KTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWE 1279
Query: 1362 CPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409
CPWH CD C + SFC CP+SFCK+H+ G +GR C EHD
Sbjct: 1280 CPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHD 1327
Score = 38.5 bits (88), Expect = 0.047
Identities = 35/121 (28%), Positives = 45/121 (37%), Gaps = 20/121 (16%)
Query: 693 RGTGMSKKDTVCQICESSGDSLIPCEGE-CCKHFHLECLGLASLPDSKFICMECKTGQHP 751
+G G + + C C G L+ C+ + C K +HL CLGL P K+ C P
Sbjct: 1231 KGEGKRQSEDECFRC-GDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWEC--------P 1281
Query: 752 CFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKA 811
C V GK S C C F + F C S C E D+ A
Sbjct: 1282 WHHCDVCGKP----STSFC-----HLCPNSFCKEHQDGTAFSCTPDGRSYC-CEHDLGAA 1331
Query: 812 S 812
S
Sbjct: 1332 S 1332
>gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 1177 bits (3045), Expect = 0.0
Identities = 617/1308 (47%), Positives = 799/1308 (61%), Gaps = 129/1308 (9%)
Query: 140 PQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESR-KEKRK 198
P P K GSPEIKLKITKT NG+ LFESS+CGD +V SE K E++ + RK
Sbjct: 111 PPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRK 170
Query: 199 KSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVP 258
+S K+DS + + ++ + S+K + P KE P
Sbjct: 171 RSIKYDSLLEQGLVEAALVS-----------KISSPSDK--KIPAKKESCP--------- 208
Query: 259 TTEVSTG------VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN--TRGAREYHV 310
+TG +K+ VGDLVWSKV YPWWPCMVS+DP L +TK+ + AR+YHV
Sbjct: 209 ----NTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHV 264
Query: 311 QFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDI 370
QFF + PERAW+ EK + ++G Q+E+L E+ KQA +EK K+ KP + RAQW++
Sbjct: 265 QFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEM 324
Query: 371 GIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQP 430
GI AE+A M+ EER ++TF+Y+ Q AK++ + + + V
Sbjct: 325 GIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAA 384
Query: 431 EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPV--KIAWKTAAA--RKSLPASITMH 486
E N V + RR ++ ++ E P + KTA A R+ + +
Sbjct: 385 E--NPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRK 442
Query: 487 KGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYS-TKGIGNKTEISVRGQDRLII 545
K ++ + + VF ++ D+ V G + E +R Q L+
Sbjct: 443 KTTVSMPRSRKGDAASQFLVFCQKHR-------DEVVAEHPDASGEEIEELLRSQWSLLS 495
Query: 546 STPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKS-TEVVPKKKIKKEQV 604
R V+ +A S G+V K++ + R + +E + E P+K+++ ++
Sbjct: 496 EKQRARYNTKFALVAPVQAEEDS-GNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKH 554
Query: 605 -----ETVPQATVKTGLQKG------------ASEISDSCKPLKKRSRASTDVEMTSSAY 647
+T+ T +T K +SD+CKPLKKR+RAST
Sbjct: 555 SLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFS 614
Query: 648 RDTSDSDSRGLSDLQVGFGKQV-DSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQI 706
+ +S S S +++ G + +SP +AD ++V S+ S S RG +KK+ VCQ+
Sbjct: 615 KSSSPSASLTENEVSDSPGDEPSESPYESADETQTEV-SVSSKKSERGV-TAKKEYVCQL 672
Query: 707 CESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCS 766
CE G SL+ CEG CC FHL CLGL+ P+ +F C EC +G H CF CK S DVKRC
Sbjct: 673 CEKPG-SLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCV 731
Query: 767 VGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIH-KASKGRMMRCLRCPVA 825
V CGKFYHEACV+K+P +FES+GFRCP H C +C + + SKG+MMRC+RCPVA
Sbjct: 732 VTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVA 791
Query: 826 YHSGDACIAAGSMLVSSYILICSNH---SKRSSNSSAVNVGFCFVCARGLIVQDHSDPMF 882
YHSGDAC+AAG +++S +IC+ H K + + VNV +CFV
Sbjct: 792 YHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFV--------------- 836
Query: 883 SSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEM 942
C KGG LLCCESCPA+FHP+CL+IEM
Sbjct: 837 ----------------------------------CSKGGSLLCCESCPAAFHPDCLNIEM 862
Query: 943 PEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFF 1002
P+G W CNDC+AGKKLH++ I+WVKLGNYRWWPAE+C+P++VP NIQ +KH++G+FPVFF
Sbjct: 863 PDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFF 922
Query: 1003 FGSHDYYWVHQGRVFPYVEGDK-SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL 1061
FGS DYYW HQ RVFPY+EGD+ S +G I + FK AL+EA RF+E+K QRE++E
Sbjct: 923 FGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQ 982
Query: 1062 EIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQY 1121
E E RKPPPYKHIK NK GKVQI AD+SEIP+CNCKP DENPCG +SECLNRML +
Sbjct: 983 ESE---RKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMF 1039
Query: 1122 ECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE 1181
ECHPQVCPAG+ CQNQCFTKR YP+ +IIKT+ +GWGL KR I+KGEFVNEYVGELIDE
Sbjct: 1040 ECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDE 1099
Query: 1182 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV 1241
EEC RIK AHEN +T+FYMLT+ KDRIIDAGPKGNYSRFMNHSC PNCET KWTVNGD
Sbjct: 1100 EECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDT 1159
Query: 1242 RVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAK 1301
RVGLFA+CDIPAG ELTFNYNLDCLGN +T C CGA NCSGFLG RPK++ ++EEK K
Sbjct: 1160 RVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGK 1219
Query: 1302 NAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE 1361
K K +RR+ K E K+ ED CF+CGDGG+LV+CD+K C KAYHL CL L + P+GKWE
Sbjct: 1220 KTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWE 1279
Query: 1362 CPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409
CPWH CD C + SFC CP+SFCK+H+ G +GR C EHD
Sbjct: 1280 CPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHD 1327
Score = 38.5 bits (88), Expect = 0.047
Identities = 35/121 (28%), Positives = 45/121 (37%), Gaps = 20/121 (16%)
Query: 693 RGTGMSKKDTVCQICESSGDSLIPCEGE-CCKHFHLECLGLASLPDSKFICMECKTGQHP 751
+G G + + C C G L+ C+ + C K +HL CLGL P K+ C P
Sbjct: 1231 KGEGKRQSEDECFRC-GDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWEC--------P 1281
Query: 752 CFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKA 811
C V GK S C C F + F C S C E D+ A
Sbjct: 1282 WHHCDVCGKP----STSFC-----HLCPNSFCKEHQDGTAFSCTPDGRSYC-CEHDLGAA 1331
Query: 812 S 812
S
Sbjct: 1332 S 1332
>gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 1177 bits (3045), Expect = 0.0
Identities = 617/1308 (47%), Positives = 799/1308 (61%), Gaps = 129/1308 (9%)
Query: 140 PQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESR-KEKRK 198
P P K GSPEIKLKITKT NG+ LFESS+CGD +V SE K E++ + RK
Sbjct: 111 PPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRK 170
Query: 199 KSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVP 258
+S K+DS + + ++ + S+K + P KE P
Sbjct: 171 RSIKYDSLLEQGLVEAALVS-----------KISSPSDK--KIPAKKESCP--------- 208
Query: 259 TTEVSTG------VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN--TRGAREYHV 310
+TG +K+ VGDLVWSKV YPWWPCMVS+DP L +TK+ + AR+YHV
Sbjct: 209 ----NTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHV 264
Query: 311 QFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDI 370
QFF + PERAW+ EK + ++G Q+E+L E+ KQA +EK K+ KP + RAQW++
Sbjct: 265 QFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEM 324
Query: 371 GIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQP 430
GI AE+A M+ EER ++TF+Y+ Q AK++ + + + V
Sbjct: 325 GIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAA 384
Query: 431 EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPV--KIAWKTAAA--RKSLPASITMH 486
E N V + RR ++ ++ E P + KTA A R+ + +
Sbjct: 385 E--NPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRK 442
Query: 487 KGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYS-TKGIGNKTEISVRGQDRLII 545
K ++ + + VF ++ D+ V G + E +R Q L+
Sbjct: 443 KTTVSMPRSRKGDAASQFLVFCQKHR-------DEVVAEHPDASGEEIEELLRSQWSLLS 495
Query: 546 STPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKS-TEVVPKKKIKKEQV 604
R V+ +A S G+V K++ + R + +E + E P+K+++ ++
Sbjct: 496 EKQRARYNTKFALVAPVQAEEDS-GNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKH 554
Query: 605 -----ETVPQATVKTGLQKG------------ASEISDSCKPLKKRSRASTDVEMTSSAY 647
+T+ T +T K +SD+CKPLKKR+RAST
Sbjct: 555 SLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFS 614
Query: 648 RDTSDSDSRGLSDLQVGFGKQV-DSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQI 706
+ +S S S +++ G + +SP +AD ++V S+ S S RG +KK+ VCQ+
Sbjct: 615 KSSSPSASLTENEVSDSPGDEPSESPYESADETQTEV-SVSSKKSERGV-TAKKEYVCQL 672
Query: 707 CESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCS 766
CE G SL+ CEG CC FHL CLGL+ P+ +F C EC +G H CF CK S DVKRC
Sbjct: 673 CEKPG-SLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVCKESKTDVKRCV 731
Query: 767 VGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIH-KASKGRMMRCLRCPVA 825
V CGKFYHEACV+K+P +FES+GFRCP H C +C + + SKG+MMRC+RCPVA
Sbjct: 732 VTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKGKMMRCVRCPVA 791
Query: 826 YHSGDACIAAGSMLVSSYILICSNH---SKRSSNSSAVNVGFCFVCARGLIVQDHSDPMF 882
YHSGDAC+AAG +++S +IC+ H K + + VNV +CFV
Sbjct: 792 YHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFV--------------- 836
Query: 883 SSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEM 942
C KGG LLCCESCPA+FHP+CL+IEM
Sbjct: 837 ----------------------------------CSKGGSLLCCESCPAAFHPDCLNIEM 862
Query: 943 PEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFF 1002
P+G W CNDC+AGKKLH++ I+WVKLGNYRWWPAE+C+P++VP NIQ +KH++G+FPVFF
Sbjct: 863 PDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFF 922
Query: 1003 FGSHDYYWVHQGRVFPYVEGDK-SFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEAL 1061
FGS DYYW HQ RVFPY+EGD+ S +G I + FK AL+EA RF+E+K QRE++E
Sbjct: 923 FGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFREIKLQREARETQ 982
Query: 1062 EIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQY 1121
E E RKPPPYKHIK NK GKVQI AD+SEIP+CNCKP DENPCG +SECLNRML +
Sbjct: 983 ESE---RKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMF 1039
Query: 1122 ECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE 1181
ECHPQVCPAG+ CQNQCFTKR YP+ +IIKT+ +GWGL KR I+KGEFVNEYVGELIDE
Sbjct: 1040 ECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDE 1099
Query: 1182 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV 1241
EEC RIK AHEN +T+FYMLT+ KDRIIDAGPKGNYSRFMNHSC PNCET KWTVNGD
Sbjct: 1100 EECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDT 1159
Query: 1242 RVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAK 1301
RVGLFA+CDIPAG ELTFNYNLDCLGN +T C CGA NCSGFLG RPK++ ++EEK K
Sbjct: 1160 RVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTSTTLSSEEKGK 1219
Query: 1302 NAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWE 1361
K K +RR+ K E K+ ED CF+CGDGG+LV+CD+K C KAYHL CL L + P+GKWE
Sbjct: 1220 KTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWE 1279
Query: 1362 CPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHD 1409
CPWH CD C + SFC CP+SFCK+H+ G +GR C EHD
Sbjct: 1280 CPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGRSYCCEHD 1327
Score = 38.5 bits (88), Expect = 0.047
Identities = 35/121 (28%), Positives = 45/121 (37%), Gaps = 20/121 (16%)
Query: 693 RGTGMSKKDTVCQICESSGDSLIPCEGE-CCKHFHLECLGLASLPDSKFICMECKTGQHP 751
+G G + + C C G L+ C+ + C K +HL CLGL P K+ C P
Sbjct: 1231 KGEGKRQSEDECFRC-GDGGQLVLCDRKFCTKAYHLSCLGLGKRPFGKWEC--------P 1281
Query: 752 CFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKA 811
C V GK S C C F + F C S C E D+ A
Sbjct: 1282 WHHCDVCGKP----STSFC-----HLCPNSFCKEHQDGTAFSCTPDGRSYC-CEHDLGAA 1331
Query: 812 S 812
S
Sbjct: 1332 S 1332
>gi|27477095 nuclear receptor binding SET domain protein 1 isoform a
[Homo sapiens]
Length = 2427
Score = 958 bits (2477), Expect = 0.0
Identities = 468/893 (52%), Positives = 578/893 (64%), Gaps = 73/893 (8%)
Query: 542 RLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSES---------EKSTE 592
+L +S P P ++ S E + G+ E K+QR+ + ES +K
Sbjct: 1101 QLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDL 1160
Query: 593 VVPKKKIKKEQVETVPQATVKTGLQK----GASEISDSCKPLKKRSRASTDVEMTSSAYR 648
+ KK + +E + T K G ++I D KP K++ + +M +
Sbjct: 1161 GLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFD--KPRKRKRQRHAAAKMQCKKVK 1218
Query: 649 DTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLS---RRGTGMSKKDTVCQ 705
+ S S+ ++ + SP T + V M +S RG G + K+ VCQ
Sbjct: 1219 NDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQ 1278
Query: 706 ICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRC 765
CE G+ L+ CE +CC FHLECLGL +P KFIC EC+TG H CF CK SG+DVKRC
Sbjct: 1279 NCEKLGELLL-CEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRC 1337
Query: 766 SVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIH-KASKGRMMRCLRCPV 824
+ CGKFYHE CV+K+P + ++KGFRC H C C + ASKGR+MRC+RCPV
Sbjct: 1338 LLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPV 1397
Query: 825 AYHSGDACIAAGSMLVSSYILICSNH---SKRSSNSSAVNVGFCFVCARGLIVQDHSDPM 881
AYH+ D C+AAGS +++S +IC NH + N VNV +CFV
Sbjct: 1398 AYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFV-------------- 1443
Query: 882 FSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIE 941
C +GG LLCC+SCPA+FH ECL+I+
Sbjct: 1444 -----------------------------------CSEGGSLLCCDSCPAAFHRECLNID 1468
Query: 942 MPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVF 1001
+PEG W CNDCKAGKK HY++IVWVK+G YRWWPAEIC+PR+VP NI ++HD+G+FPV
Sbjct: 1469 IPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVL 1528
Query: 1002 FFGSHDYYWVHQGRVFPYVEGDKSFAEGQ-TSINKTFKKALEEAAKRFQELKAQRESKEA 1060
FFGS+DY W HQ RVFPY+EGD S + ++ T+KKAL+EAA RF+ELKAQ+E ++
Sbjct: 1529 FFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQL 1588
Query: 1061 LEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQ 1120
E KN +KPPPYKHIK N+ IG+VQI ADLSEIPRCNCK DENPCG++SEC+NRML
Sbjct: 1589 QEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLL 1648
Query: 1121 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELID 1180
YECHP VCPAG RCQNQCF+KR YP+ EI +T +RGWGLRTK IKKGEFVNEYVGELID
Sbjct: 1649 YECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELID 1708
Query: 1181 EEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGD 1240
EEECR RI+ A E+ +TNFYMLT+ KDRIIDAGPKGNY+RFMNH C PNCETQKW+VNGD
Sbjct: 1709 EEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGD 1768
Query: 1241 VRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKA 1300
RVGLFAL DI AG ELTFNYNL+CLGNG+T C CGA NCSGFLGVRPK+ +T E+
Sbjct: 1769 TRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSK 1828
Query: 1301 KNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKW 1360
K K +Q +R+ + E + ED CF CGD G+LV C K CPK YH CLNLT+ P GKW
Sbjct: 1829 KFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKW 1888
Query: 1361 ECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAP 1413
ECPWHQCD C A SFCE CP SFCK H +G L S L+GRL C+EHDP P
Sbjct: 1889 ECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGP 1941
Score = 89.4 bits (220), Expect = 2e-17
Identities = 44/118 (37%), Positives = 69/118 (58%), Gaps = 6/118 (5%)
Query: 263 STGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI---NTRGAREYHVQFFSNQPER 319
ST +K++VGDL+W+K PWWPC + SDP + H+K+ N R R+Y+V+ F + ER
Sbjct: 47 STPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSER 106
Query: 320 AWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEK 377
AWV K + ++G Q+EEL ++ EK R PQ+ ++W+ + AE+
Sbjct: 107 AWVAGKAIVMFEGRHQFEEL--PVLRRRGKQKEK-GYRHKVPQKILSKWEASVGLAEQ 161
Score = 40.0 bits (92), Expect = 0.016
Identities = 27/107 (25%), Positives = 44/107 (41%), Gaps = 10/107 (9%)
Query: 261 EVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERA 320
+ G K ++VW KVG Y WWP + + + E+ V FF + +
Sbjct: 1478 DCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSN-DYL 1536
Query: 321 WVHEKRVREY---------KGHKQYEELLAEATKQASNHSEKQKIRK 358
W H+ RV Y K K + +A ++A+ E+ K +K
Sbjct: 1537 WTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQK 1583
>gi|19923586 nuclear receptor binding SET domain protein 1 isoform b
[Homo sapiens]
Length = 2696
Score = 958 bits (2477), Expect = 0.0
Identities = 468/893 (52%), Positives = 578/893 (64%), Gaps = 73/893 (8%)
Query: 542 RLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSES---------EKSTE 592
+L +S P P ++ S E + G+ E K+QR+ + ES +K
Sbjct: 1370 QLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDL 1429
Query: 593 VVPKKKIKKEQVETVPQATVKTGLQK----GASEISDSCKPLKKRSRASTDVEMTSSAYR 648
+ KK + +E + T K G ++I D KP K++ + +M +
Sbjct: 1430 GLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFD--KPRKRKRQRHAAAKMQCKKVK 1487
Query: 649 DTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLS---RRGTGMSKKDTVCQ 705
+ S S+ ++ + SP T + V M +S RG G + K+ VCQ
Sbjct: 1488 NDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQ 1547
Query: 706 ICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRC 765
CE G+ L+ CE +CC FHLECLGL +P KFIC EC+TG H CF CK SG+DVKRC
Sbjct: 1548 NCEKLGELLL-CEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRC 1606
Query: 766 SVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIH-KASKGRMMRCLRCPV 824
+ CGKFYHE CV+K+P + ++KGFRC H C C + ASKGR+MRC+RCPV
Sbjct: 1607 LLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPV 1666
Query: 825 AYHSGDACIAAGSMLVSSYILICSNH---SKRSSNSSAVNVGFCFVCARGLIVQDHSDPM 881
AYH+ D C+AAGS +++S +IC NH + N VNV +CFV
Sbjct: 1667 AYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFV-------------- 1712
Query: 882 FSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIE 941
C +GG LLCC+SCPA+FH ECL+I+
Sbjct: 1713 -----------------------------------CSEGGSLLCCDSCPAAFHRECLNID 1737
Query: 942 MPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVF 1001
+PEG W CNDCKAGKK HY++IVWVK+G YRWWPAEIC+PR+VP NI ++HD+G+FPV
Sbjct: 1738 IPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVL 1797
Query: 1002 FFGSHDYYWVHQGRVFPYVEGDKSFAEGQ-TSINKTFKKALEEAAKRFQELKAQRESKEA 1060
FFGS+DY W HQ RVFPY+EGD S + ++ T+KKAL+EAA RF+ELKAQ+E ++
Sbjct: 1798 FFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQL 1857
Query: 1061 LEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQ 1120
E KN +KPPPYKHIK N+ IG+VQI ADLSEIPRCNCK DENPCG++SEC+NRML
Sbjct: 1858 QEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLL 1917
Query: 1121 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELID 1180
YECHP VCPAG RCQNQCF+KR YP+ EI +T +RGWGLRTK IKKGEFVNEYVGELID
Sbjct: 1918 YECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELID 1977
Query: 1181 EEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGD 1240
EEECR RI+ A E+ +TNFYMLT+ KDRIIDAGPKGNY+RFMNH C PNCETQKW+VNGD
Sbjct: 1978 EEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGD 2037
Query: 1241 VRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKA 1300
RVGLFAL DI AG ELTFNYNL+CLGNG+T C CGA NCSGFLGVRPK+ +T E+
Sbjct: 2038 TRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSK 2097
Query: 1301 KNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKW 1360
K K +Q +R+ + E + ED CF CGD G+LV C K CPK YH CLNLT+ P GKW
Sbjct: 2098 KFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGKW 2157
Query: 1361 ECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAP 1413
ECPWHQCD C A SFCE CP SFCK H +G L S L+GRL C+EHDP P
Sbjct: 2158 ECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGP 2210
Score = 98.2 bits (243), Expect = 5e-20
Identities = 85/317 (26%), Positives = 134/317 (42%), Gaps = 76/317 (23%)
Query: 133 PPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGD----------------- 175
P P ++ P SPE+++K+TKTI+NG FE+ C D
Sbjct: 118 PGGPTALAMKQEPSCNNSPELQVKVTKTIKNGFLHFENFTCVDDADVDSEMDPEQPVTED 177
Query: 176 -----LLNEVQASE----HTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPE---E 223
+ E Q + TKS++ + + + SR KS +P L P+ +
Sbjct: 178 ESIEEIFEETQTNATCNYETKSENGVKVAMGSEQDSTPESRHGAVKSPFLP-LAPQTETQ 236
Query: 224 QNRPNERVDTVSEKPR---------------EEPVLKEEAPVQ----------------P 252
+N+ VD +EK EE + Q P
Sbjct: 237 KNKQRNEVDGSNEKAALLPAPFSLGDTNITIEEQLNSINLSFQDDPDSSTSTLGNMLELP 296
Query: 253 ILSSVPTTEV---------STGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI--- 300
SS T++ ST +K++VGDL+W+K PWWPC + SDP + H+K+
Sbjct: 297 GTSSSSTSQELPFCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVS 356
Query: 301 NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR 360
N R R+Y+V+ F + ERAWV K + ++G Q+EEL ++ EK R
Sbjct: 357 NRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEEL--PVLRRRGKQKEK-GYRHKV 413
Query: 361 PQRERAQWDIGIAHAEK 377
PQ+ ++W+ + AE+
Sbjct: 414 PQKILSKWEASVGLAEQ 430
Score = 40.0 bits (92), Expect = 0.016
Identities = 27/107 (25%), Positives = 44/107 (41%), Gaps = 10/107 (9%)
Query: 261 EVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERA 320
+ G K ++VW KVG Y WWP + + + E+ V FF + +
Sbjct: 1747 DCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSN-DYL 1805
Query: 321 WVHEKRVREY---------KGHKQYEELLAEATKQASNHSEKQKIRK 358
W H+ RV Y K K + +A ++A+ E+ K +K
Sbjct: 1806 WTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQK 1852
>gi|19913356 Wolf-Hirschhorn syndrome candidate 1 protein isoform 3
[Homo sapiens]
Length = 647
Score = 222 bits (566), Expect = 2e-57
Identities = 171/549 (31%), Positives = 262/549 (47%), Gaps = 70/549 (12%)
Query: 140 PQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESR-KEKRK 198
P P K GSPEIKLKITKT NG+ LFESS+CGD +V SE K E++ + RK
Sbjct: 111 PPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRK 170
Query: 199 KSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVP 258
+S K+DS + + ++ + S+K + P KE P
Sbjct: 171 RSIKYDSLLEQGLVEAALVS-----------KISSPSDK--KIPAKKESCP--------- 208
Query: 259 TTEVSTG------VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN--TRGAREYHV 310
+TG +K+ VGDLVWSKV YPWWPCMVS+DP L +TK+ + AR+YHV
Sbjct: 209 ----NTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHV 264
Query: 311 QFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDI 370
QFF + PERAW+ EK + ++G Q+E+L E+ KQA +EK K+ KP + RAQW++
Sbjct: 265 QFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEM 324
Query: 371 GIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQP 430
GI AE+A M+ EER ++TF+Y+ Q AK++ + + + V
Sbjct: 325 GIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAA 384
Query: 431 EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPV--KIAWKTAAA--RKSLPASITMH 486
E N V + RR ++ ++ E P + KTA A R+ + +
Sbjct: 385 E--NPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRK 442
Query: 487 KGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYS-TKGIGNKTEISVRGQDRLII 545
K ++ + + VF K D+ V G + E +R Q L+
Sbjct: 443 KTTVSMPRSRKGDAASQFLVFC-------QKHRDEVVAEHPDASGEEIEELLRSQWSLL- 494
Query: 546 STPNQRNEKPTQ-SVSSPEATSGSTGSVEKKQQRRSIRTRSESEKS-TEVVPKKKIKKE- 602
+ QR T+ ++ +P +G+V K++ + R + +E + E P+K+++ +
Sbjct: 495 -SEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDK 553
Query: 603 ----QVETVPQATVKTG------------LQKGASEISDSCKPLKKRSRASTDVEMTSSA 646
+ +T+ T +T Q +SD+CKPLKKR+RAST
Sbjct: 554 HSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGF 613
Query: 647 YRDTSDSDS 655
+ +S S S
Sbjct: 614 SKSSSPSAS 622
Score = 35.4 bits (80), Expect = 0.40
Identities = 44/232 (18%), Positives = 88/232 (37%), Gaps = 44/232 (18%)
Query: 957 KLHYKQIVWVKLGNYRWWPAEICNPRSVPL-----NIQGLKHDLGDFPVFFFG-SHDYYW 1010
K + +VW K+ Y WWP C + PL ++G K + V FFG + + W
Sbjct: 219 KYNVGDLVWSKVSGYPWWP---CMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAW 275
Query: 1011 VHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELK-----------------A 1053
+ + + + EG+ K +++ ++A + +++K
Sbjct: 276 IFEKSLVAF--------EGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIV 327
Query: 1054 QRESKEALEIEKNSRK-----PPPYKHIKANKVIGKVQIQVADLSEIPRCN--CKPADEN 1106
Q E ++ +E+ K H+ +V + I L E+ + + A EN
Sbjct: 328 QAEEAASMSVEERKAKFTFLYVGDQLHLNP-QVAKEAGIAAESLGEMAESSGVSEEAAEN 386
Query: 1107 PCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWG 1158
P + EC+ ++ ++C + + ++ + P RRG G
Sbjct: 387 PKSVREECI--PMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVG 436
>gi|6594683 Wolf-Hirschhorn syndrome candidate 1 protein isoform 4
[Homo sapiens]
Length = 629
Score = 222 bits (566), Expect = 2e-57
Identities = 171/549 (31%), Positives = 262/549 (47%), Gaps = 70/549 (12%)
Query: 140 PQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESR-KEKRK 198
P P K GSPEIKLKITKT NG+ LFESS+CGD +V SE K E++ + RK
Sbjct: 111 PPNTTPIKNGSPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRK 170
Query: 199 KSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVP 258
+S K+DS + + ++ + S+K + P KE P
Sbjct: 171 RSIKYDSLLEQGLVEAALVS-----------KISSPSDK--KIPAKKESCP--------- 208
Query: 259 TTEVSTG------VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN--TRGAREYHV 310
+TG +K+ VGDLVWSKV YPWWPCMVS+DP L +TK+ + AR+YHV
Sbjct: 209 ----NTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHV 264
Query: 311 QFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDI 370
QFF + PERAW+ EK + ++G Q+E+L E+ KQA +EK K+ KP + RAQW++
Sbjct: 265 QFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEM 324
Query: 371 GIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQP 430
GI AE+A M+ EER ++TF+Y+ Q AK++ + + + V
Sbjct: 325 GIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAGIAAESLGEMAESSGVSEEAA 384
Query: 431 EQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPV--KIAWKTAAA--RKSLPASITMH 486
E N V + RR ++ ++ E P + KTA A R+ + +
Sbjct: 385 E--NPKSVREECIPMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRK 442
Query: 487 KGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYS-TKGIGNKTEISVRGQDRLII 545
K ++ + + VF K D+ V G + E +R Q L+
Sbjct: 443 KTTVSMPRSRKGDAASQFLVFC-------QKHRDEVVAEHPDASGEEIEELLRSQWSLL- 494
Query: 546 STPNQRNEKPTQ-SVSSPEATSGSTGSVEKKQQRRSIRTRSESEKS-TEVVPKKKIKKE- 602
+ QR T+ ++ +P +G+V K++ + R + +E + E P+K+++ +
Sbjct: 495 -SEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDK 553
Query: 603 ----QVETVPQATVKTG------------LQKGASEISDSCKPLKKRSRASTDVEMTSSA 646
+ +T+ T +T Q +SD+CKPLKKR+RAST
Sbjct: 554 HSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGF 613
Query: 647 YRDTSDSDS 655
+ +S S S
Sbjct: 614 SKSSSPSAS 622
Score = 35.4 bits (80), Expect = 0.40
Identities = 44/232 (18%), Positives = 88/232 (37%), Gaps = 44/232 (18%)
Query: 957 KLHYKQIVWVKLGNYRWWPAEICNPRSVPL-----NIQGLKHDLGDFPVFFFG-SHDYYW 1010
K + +VW K+ Y WWP C + PL ++G K + V FFG + + W
Sbjct: 219 KYNVGDLVWSKVSGYPWWP---CMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAW 275
Query: 1011 VHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELK-----------------A 1053
+ + + + EG+ K +++ ++A + +++K
Sbjct: 276 IFEKSLVAF--------EGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQWEMGIV 327
Query: 1054 QRESKEALEIEKNSRK-----PPPYKHIKANKVIGKVQIQVADLSEIPRCN--CKPADEN 1106
Q E ++ +E+ K H+ +V + I L E+ + + A EN
Sbjct: 328 QAEEAASMSVEERKAKFTFLYVGDQLHLNP-QVAKEAGIAAESLGEMAESSGVSEEAAEN 386
Query: 1107 PCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWG 1158
P + EC+ ++ ++C + + ++ + P RRG G
Sbjct: 387 PKSVREECI--PMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVG 436
>gi|197313748 SET domain containing 2 [Homo sapiens]
Length = 2564
Score = 194 bits (494), Expect = 4e-49
Identities = 99/240 (41%), Positives = 141/240 (58%), Gaps = 13/240 (5%)
Query: 1074 KHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDR 1133
K K+++ I ++Q + LS+ R E CG +CLNR+L EC + CP GD
Sbjct: 1486 KKNKSHRDIKRMQCECTPLSKDERAQ----GEIACG--EDCLNRLLMIECSSR-CPNGDY 1538
Query: 1134 CQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHE 1193
C N+ F ++ + D E+I TE++GWGLR + + FV EY GE++D +E + R+K
Sbjct: 1539 CSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYAR 1598
Query: 1194 NSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPA 1253
N ++Y + + D IIDA KGN SRFMNHSC PNCETQKWTVNG +RVG F +P+
Sbjct: 1599 NKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPS 1658
Query: 1254 GMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIK 1313
G ELTF+Y G +C CG+ NC G+LG + + +A K+K++R + K
Sbjct: 1659 GSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSI------RAAGGKMKKERSRKK 1712
>gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]
Length = 2964
Score = 188 bits (478), Expect = 3e-47
Identities = 100/261 (38%), Positives = 151/261 (57%), Gaps = 13/261 (4%)
Query: 1068 RKP--PPYKHIKANKVIGKVQIQVADLS--EIPRCNCK-PADENPCGLESECLNRMLQYE 1122
+KP P YK I++N V + V LS E CNCK P D+ G +CLNRM+ E
Sbjct: 2062 KKPDVPLYKKIRSN-----VYVDVKPLSGYEATTCNCKKPDDDTRKGCVDDCLNRMIFAE 2116
Query: 1123 CHPQVCPAGDRCQNQCFTKRLYPDA-EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDE 1181
C P CP G++C NQ + + E + E +GWG+RTK +K G+F+ EY+GE++ E
Sbjct: 2117 CSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSE 2176
Query: 1182 EECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV 1241
+E R R+ + N ++ Y L + +ID+ GN +RF+NHSC+PNCE QKW+VNG
Sbjct: 2177 QEFRNRMIEQYHNH-SDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVY 2235
Query: 1242 RVGLFALCDIPAGMELTFNYNLDCLGNGRTE-CHCGADNCSGFLGVRPKSACASTNEEKA 1300
R+GL+AL D+PAG ELT++YN + + C CG + C G +G + + T+ + +
Sbjct: 2236 RIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNS 2295
Query: 1301 KNAKLKQKRRKIKTEPKQMHE 1321
+ +K + K + K H+
Sbjct: 2296 QPMATHKKSGRSKEKRKSKHK 2316
>gi|19923202 enhancer of zeste homolog 1 [Homo sapiens]
Length = 747
Score = 99.8 bits (247), Expect = 2e-20
Identities = 62/182 (34%), Positives = 94/182 (51%), Gaps = 20/182 (10%)
Query: 1098 CNCKPADENP---CGLESECLNR-----MLQYECHPQVC---PAGDR-------CQNQCF 1139
C C P +N C +++C + + EC P +C A + C+N
Sbjct: 548 CQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSI 607
Query: 1140 TKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNF 1199
+ L + ++ GWG K S++K EF++EY GELI ++E R K ++ +++F
Sbjct: 608 QRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGK-VYDKYMSSF 666
Query: 1200 YMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTF 1259
+ + D ++DA KGN RF NHS NPNC + VNGD R+G+FA I AG EL F
Sbjct: 667 -LFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFF 725
Query: 1260 NY 1261
+Y
Sbjct: 726 DY 727
>gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]
Length = 350
Score = 96.3 bits (238), Expect = 2e-19
Identities = 66/184 (35%), Positives = 88/184 (47%), Gaps = 21/184 (11%)
Query: 1121 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTER-RGWGLRTKRSIKKGEFVNEYVGELI 1179
YEC+ + C G C N+ K I +T RGWG++T IK+ FV EYVGE+I
Sbjct: 167 YECNSR-CQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVI 225
Query: 1180 DEEECRLRIKRAHENSVTNFYMLTVTKDRI-IDAGPKGNYSRFMNHSCNPNCET-QKWTV 1237
EE R + +T + L D +DA GN S F+NHSC+PN + +
Sbjct: 226 TSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFID 285
Query: 1238 NGDV---RVGLFALCDIPAGMELTFNYNLDCLGN--------------GRTECHCGADNC 1280
N D R+ LF+ I AG ELTF+Y + G+ RT C CGA C
Sbjct: 286 NLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTC 345
Query: 1281 SGFL 1284
G+L
Sbjct: 346 RGYL 349
>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
Length = 412
Score = 94.4 bits (233), Expect = 7e-19
Identities = 64/193 (33%), Positives = 88/193 (45%), Gaps = 30/193 (15%)
Query: 1121 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTER-RGWGLRTKRSIKKGEFVNEYVGELI 1179
YEC+ + C G C N+ K + D I +T+ RGWG+RT I+K FV EYVGE+I
Sbjct: 220 YECNSR-CRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEII 278
Query: 1180 DEEECRLRIKRAHENSVTNFYMLTVTKD-RIIDAGPKGNYSRFMNHSCNPNCETQKWTVN 1238
EE R + T + L +D +DA GN S F+NHSC+PN + ++
Sbjct: 279 TSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFID 338
Query: 1239 G----DVRVGLFALCDIPAGMELTFNYNLDC-----------------------LGNGRT 1271
R+ FA I AG ELTF+YN+ R
Sbjct: 339 NLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRI 398
Query: 1272 ECHCGADNCSGFL 1284
EC CG ++C +L
Sbjct: 399 ECKCGTESCRKYL 411
>gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens]
Length = 707
Score = 94.4 bits (233), Expect = 7e-19
Identities = 59/179 (32%), Positives = 89/179 (49%), Gaps = 17/179 (9%)
Query: 1093 SEIPRCNCKPADENPCGLESECLNRMLQYECHPQVC---PAGDR-------CQNQCFTKR 1142
+ P C CK C + +C + EC P +C A D C+N +
Sbjct: 516 NRFPGCRCKAQ----CNTK-QCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRG 570
Query: 1143 LYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYML 1202
+ ++ GWG+ K ++K EF++EY GE+I ++E R K ++ + +F +
Sbjct: 571 SKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF-LF 628
Query: 1203 TVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNY 1261
+ D ++DA KGN RF NHS NPNC + VNGD R+G+FA I G EL F+Y
Sbjct: 629 NLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY 687
>gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens]
Length = 751
Score = 94.4 bits (233), Expect = 7e-19
Identities = 59/179 (32%), Positives = 89/179 (49%), Gaps = 17/179 (9%)
Query: 1093 SEIPRCNCKPADENPCGLESECLNRMLQYECHPQVC---PAGDR-------CQNQCFTKR 1142
+ P C CK C + +C + EC P +C A D C+N +
Sbjct: 560 NRFPGCRCKAQ----CNTK-QCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRG 614
Query: 1143 LYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYML 1202
+ ++ GWG+ K ++K EF++EY GE+I ++E R K ++ + +F +
Sbjct: 615 SKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF-LF 672
Query: 1203 TVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNY 1261
+ D ++DA KGN RF NHS NPNC + VNGD R+G+FA I G EL F+Y
Sbjct: 673 NLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY 731
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 92.0 bits (227), Expect = 4e-18
Identities = 48/134 (35%), Positives = 72/134 (53%), Gaps = 1/134 (0%)
Query: 1151 KTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRII 1210
K+ WGL I E V EYVG+ I + +R KR + + + YM V D II
Sbjct: 1790 KSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTII 1849
Query: 1211 DAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGR 1270
DA GN++RF+NHSCNPNC + TV ++ +++ I E+T++Y + + +
Sbjct: 1850 DATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFP-IEDVK 1908
Query: 1271 TECHCGADNCSGFL 1284
C CG++NC G L
Sbjct: 1909 IPCLCGSENCRGTL 1922
Score = 31.6 bits (70), Expect = 5.8
Identities = 12/20 (60%), Positives = 13/20 (65%)
Query: 128 PSPPQPPPPPSVPQTVIPKK 147
P PP PPPPP V T +P K
Sbjct: 1545 PQPPPPPPPPPVEPTKLPFK 1564
>gi|194306650 SET domain and mariner transposase fusion [Homo sapiens]
Length = 684
Score = 90.9 bits (224), Expect = 8e-18
Identities = 61/186 (32%), Positives = 92/186 (49%), Gaps = 25/186 (13%)
Query: 1121 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELID 1180
+EC+ +C D C+N+ K L ++ KT ++GWGLRT I KG FV EY GE++
Sbjct: 116 FECNV-LCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLG 174
Query: 1181 EEECRLRIKRAHENSVTNFYMLTVTK--------DRIIDAGPKGNYSRFMNHSCNPNCET 1232
E + RI S +N Y++ + + + +D GN RF+NHSC PN
Sbjct: 175 FSEVQRRI-HLQTKSDSN-YIIAIREHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLM 232
Query: 1233 QKWTVNGDV-RVGLFALCDIPAGMELTFNYNLDCL-------------GNGRTECHCGAD 1278
++ V ++ LFA DI EL+++Y+ L G R C+CGA
Sbjct: 233 IPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAK 292
Query: 1279 NCSGFL 1284
+C+ FL
Sbjct: 293 SCTAFL 298
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
sapiens]
Length = 3969
Score = 84.7 bits (208), Expect = 6e-16
Identities = 45/137 (32%), Positives = 73/137 (53%), Gaps = 2/137 (1%)
Query: 1149 IIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDR 1208
+ ++ G GL KR+I GE V EY G +I + R ++ +++ YM +
Sbjct: 3833 VYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKR-EKYYDSKGIGCYMFRIDDSE 3891
Query: 1209 IIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCL-G 1267
++DA GN +RF+NHSC PNC ++ ++G + +FA+ I G ELT++Y
Sbjct: 3892 VVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDA 3951
Query: 1268 NGRTECHCGADNCSGFL 1284
+ + C+CGA C FL
Sbjct: 3952 SNKLPCNCGAKKCRKFL 3968
Score = 37.0 bits (84), Expect = 0.14
Identities = 40/147 (27%), Positives = 60/147 (40%), Gaps = 9/147 (6%)
Query: 62 TTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRP 121
++ +L PLT PSS+S + S + + N + S T S N RP
Sbjct: 763 SSSELSPLTP--PSSVS----SSLSISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRP 816
Query: 122 HEILEKPSPP--QPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNE 179
+ P+ P P P P +T K K + + R+ + S+ D E
Sbjct: 817 RKQTSAPAEPFSSSSPTPLFPWFTPGSQTERGRNKDKAPEELSKDRDA-DKSVEKDKSRE 875
Query: 180 VQASEHTKSKHESRKEKRKKSNKHDSS 206
++K ESRKEKRKK ++ SS
Sbjct: 876 RDREREKENKRESRKEKRKKGSEIQSS 902
Score = 30.8 bits (68), Expect = 9.8
Identities = 18/43 (41%), Positives = 21/43 (48%), Gaps = 5/43 (11%)
Query: 115 EIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTG-SPEIKLK 156
E+P T P E P QPPPP S P+ KK P I +K
Sbjct: 1318 EVPKTTPSE----PKKKQPPPPESGPEQSKQKKVAPRPSIPVK 1356
Score = 30.8 bits (68), Expect = 9.8
Identities = 14/37 (37%), Positives = 17/37 (45%), Gaps = 6/37 (16%)
Query: 922 RLLCCESCPASFHPECLSIEMP------EGCWNCNDC 952
+LL C C S+HPECL P + W C C
Sbjct: 1494 QLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKC 1530
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 82.4 bits (202), Expect = 3e-15
Identities = 43/128 (33%), Positives = 66/128 (51%), Gaps = 1/128 (0%)
Query: 1157 WGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKG 1216
WGL I E V EYVG+ I + +R KR + + + Y+ V D IIDA G
Sbjct: 1580 WGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCG 1639
Query: 1217 NYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCG 1276
N +RF+NH C PNC + T+ ++ +++ I E+T++Y L + + C CG
Sbjct: 1640 NLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFP-LEDNKIPCLCG 1698
Query: 1277 ADNCSGFL 1284
++C G L
Sbjct: 1699 TESCRGSL 1706
Score = 33.1 bits (74), Expect = 2.0
Identities = 31/108 (28%), Positives = 38/108 (35%), Gaps = 14/108 (12%)
Query: 33 AFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQY 92
A D S++ G P PA ED+ P +G P + K NQ
Sbjct: 523 ARDTGSEVPSGSGHGPCTPP-----PAPANFEDVAPTGSGEPGAT---RESPKANGQNQ- 573
Query: 93 PNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVP 140
S G S D S P P + +P PP PPPPP P
Sbjct: 574 --ASPCSSGDDMEISDDDRGGSPPPAPTPPQ---QPPPPPPPPPPPPP 616
Score = 33.1 bits (74), Expect = 2.0
Identities = 48/208 (23%), Positives = 80/208 (38%), Gaps = 44/208 (21%)
Query: 94 NGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSV--PQTVIPKKTGSP 151
+ S++G GA+R S R H +P PP PPPPP P++ + T
Sbjct: 1380 SSSSDGEGALRRRS-----------LRSHARRRRPPPPPPPPPPRAYEPRSEFEQMTILY 1428
Query: 152 EI-----------KLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKS 200
+I L++T L + + D LN+ HT + + K KR+
Sbjct: 1429 DIWNSGLDSEDMSYLRLTY-----ERLLQQTSGADWLNDTHWVHHTITNLTTPKRKRRPQ 1483
Query: 201 N---KHDSSRSEERKSHKIPKLEPEE-------QNRPNERVDTVSEKPREEPVLKEEAPV 250
+ +H + + + I K E ++ R E VDT VL E
Sbjct: 1484 DGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQG----TNRVLSERRSE 1539
Query: 251 Q-PILSSVPTTEVSTGVKFQVGDLVWSK 277
Q +LS++ T+ + ++ L + K
Sbjct: 1540 QRRLLSAIGTSAIMDSDLLKLNQLKFRK 1567
Score = 31.6 bits (70), Expect = 5.8
Identities = 25/94 (26%), Positives = 36/94 (38%), Gaps = 4/94 (4%)
Query: 170 SSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNE 229
SS C + ++ T S S+ SS S S + + EE+ RP
Sbjct: 1014 SSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERP-A 1072
Query: 230 RVDTVSEKPREEPV---LKEEAPVQPILSSVPTT 260
+ + S PRE PV E PV ++ P T
Sbjct: 1073 ALPSASPPPREVPVPTPAPVEVPVPERVAGSPVT 1106
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform
b [Homo sapiens]
Length = 1176
Score = 82.4 bits (202), Expect = 3e-15
Identities = 69/239 (28%), Positives = 112/239 (46%), Gaps = 38/239 (15%)
Query: 1070 PPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENP---CG-LESECL----NRMLQ- 1120
P YK+I N + I +++ + C C + CG L C R+LQ
Sbjct: 913 PEDYKYISENCETSTMNID-RNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQE 971
Query: 1121 ---------YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFV 1171
+EC+ Q C C+N+ + ++ +T + GWG+R ++I +G F+
Sbjct: 972 FNKIEPPLIFECN-QACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFI 1030
Query: 1172 NEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKD---RIIDAGPKGNYSRFMNHSCNP 1228
EYVGELI + E +R ++ + N KD IDA GN SRF+NH C+P
Sbjct: 1031 CEYVGELISDAEADVREDDSYLFDLDN-------KDGEVYCIDARYYGNISRFINHLCDP 1083
Query: 1229 N-CETQKWTVNGDV---RVGLFALCDIPAGMELTFNYNLDCLGNGRTE---CHCGADNC 1280
N + + ++ D+ R+ F+ DI G EL F+Y D + +++ C CG++ C
Sbjct: 1084 NIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYG-DRFWDIKSKYFTCQCGSEKC 1141
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform
a [Homo sapiens]
Length = 1210
Score = 82.4 bits (202), Expect = 3e-15
Identities = 69/239 (28%), Positives = 112/239 (46%), Gaps = 38/239 (15%)
Query: 1070 PPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENP---CG-LESECL----NRMLQ- 1120
P YK+I N + I +++ + C C + CG L C R+LQ
Sbjct: 947 PEDYKYISENCETSTMNID-RNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQE 1005
Query: 1121 ---------YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFV 1171
+EC+ Q C C+N+ + ++ +T + GWG+R ++I +G F+
Sbjct: 1006 FNKIEPPLIFECN-QACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFI 1064
Query: 1172 NEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKD---RIIDAGPKGNYSRFMNHSCNP 1228
EYVGELI + E +R ++ + N KD IDA GN SRF+NH C+P
Sbjct: 1065 CEYVGELISDAEADVREDDSYLFDLDN-------KDGEVYCIDARYYGNISRFINHLCDP 1117
Query: 1229 N-CETQKWTVNGDV---RVGLFALCDIPAGMELTFNYNLDCLGNGRTE---CHCGADNC 1280
N + + ++ D+ R+ F+ DI G EL F+Y D + +++ C CG++ C
Sbjct: 1118 NIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYG-DRFWDIKSKYFTCQCGSEKC 1175
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 80.9 bits (198), Expect = 8e-15
Identities = 42/133 (31%), Positives = 71/133 (53%), Gaps = 2/133 (1%)
Query: 1149 IIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDR 1208
+ ++ +G GL + ++K V EY+G +I E R ++ +E YM + +
Sbjct: 5401 LARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRR-EKIYEEQNRGIYMFRINNEH 5459
Query: 1209 IIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGN 1268
+IDA G +R++NHSC PNC + T + + ++ + + IP G ELT++Y D +
Sbjct: 5460 VIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDD 5519
Query: 1269 -GRTECHCGADNC 1280
+ CHCGA NC
Sbjct: 5520 QHKIPCHCGAWNC 5532
Score = 47.4 bits (111), Expect = 1e-04
Identities = 37/137 (27%), Positives = 56/137 (40%), Gaps = 12/137 (8%)
Query: 672 PSATADADVSDVQSMDSSLSRRGTGMSK-KDTVCQICESSGD--SLIPCEGECCKHFHLE 728
P ATA ++++ G + ++ C +CE G+ L C C H+H
Sbjct: 196 PCATASGSFLSMKTLQLLCPEHSEGAAYLEEARCAVCEGPGELCDLFFCTS-CGHHYHGA 254
Query: 729 CL--GLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAI 786
CL L + + + C ECK C +C+ G D K C K YH C+ K P
Sbjct: 255 CLDTALTARKRAGWQCPECKV----CQACRKPGNDSKMLVCETCDKGYHTFCL-KPPMEE 309
Query: 787 FESKGFRCPQ-HCCSAC 802
+ ++C C AC
Sbjct: 310 LPAHSWKCKACRVCRAC 326
Score = 45.4 bits (106), Expect = 4e-04
Identities = 24/63 (38%), Positives = 34/63 (53%), Gaps = 6/63 (9%)
Query: 1322 DYCFQCGDGGELVMCDKKDCPKAYHLLCLN--LTQPPYGKWECPW-HQCDECSSAAVSF- 1377
+ C Q D L++CD DC +YH CL+ L P G W+C W C +C +A+ F
Sbjct: 1431 EVCGQASDPSRLLLCD--DCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFH 1488
Query: 1378 CEF 1380
CE+
Sbjct: 1489 CEW 1491
Score = 40.0 bits (92), Expect = 0.016
Identities = 40/172 (23%), Positives = 63/172 (36%), Gaps = 28/172 (16%)
Query: 802 CSMEKDIHKASKGRMMRCLR-----------CPVAYHSGDACIAAGSMLVSSYILICSNH 850
C ++K I R C R CP YH A + + + + L+C H
Sbjct: 158 CGVDKAIFSGISQRCSHCTRLGASIPCRSPGCPRLYHFPCATASGSFLSMKTLQLLCPEH 217
Query: 851 SKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHY---LLNESNRAELMKLPMI 907
S+ ++ + C VC + D +F + HY L+ + A
Sbjct: 218 SE---GAAYLEEARCAVCEGPGELCD----LFFCTSCGHHYHGACLDTALTARKRAGWQC 270
Query: 908 PSSSASKKKCEKGG---RLLCCESCPASFHPECLS---IEMPEGCWNCNDCK 953
P + C K G ++L CE+C +H CL E+P W C C+
Sbjct: 271 PECKVC-QACRKPGNDSKMLVCETCDKGYHTFCLKPPMEELPAHSWKCKACR 321
Score = 38.1 bits (87), Expect = 0.061
Identities = 25/93 (26%), Positives = 38/93 (40%), Gaps = 13/93 (13%)
Query: 739 KFICMECKTGQHPCFSCKVSGKDVKR--CSVGACGKFYHEACVRKFPTAIFESKGFRCPQ 796
KF+ M Q C C G+ + + C + YH CV T + KG+RC +
Sbjct: 1372 KFVLM-----QDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVE 1426
Query: 797 -HCCSACSMEKDIHKASKGRMMRCLRCPVAYHS 828
C C D R++ C C ++YH+
Sbjct: 1427 CIVCEVCGQASD-----PSRLLLCDDCDISYHT 1454
Score = 35.0 bits (79), Expect = 0.52
Identities = 14/34 (41%), Positives = 19/34 (55%), Gaps = 3/34 (8%)
Query: 922 RLLCCESCPASFHPECLS---IEMPEGCWNCNDC 952
RLL C+ C S+H CL + +P+G W C C
Sbjct: 1441 RLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWC 1474
Score = 33.5 bits (75), Expect = 1.5
Identities = 25/103 (24%), Positives = 39/103 (37%), Gaps = 17/103 (16%)
Query: 1324 CFQCGDGGELVMCDKKDCPKAYHLLCLN--LTQPPYGKWECPWHQCDECSSAAVSFCEFC 1381
C + G+ ++++C+ C K YH CL + + P W+C C C + E
Sbjct: 279 CRKPGNDSKMLVCET--CDKGYHTFCLKPPMEELPAHSWKC--KACRVCRACGAGSAELN 334
Query: 1382 PHS----------FCKDHEKGALVPSALEGRL-CCSEHDPMAP 1413
P+S C + G + S E CS P P
Sbjct: 335 PNSEWFENYSLCHRCHKAQGGQTIRSVAEQHTPVCSRFSPPEP 377
Score = 30.8 bits (68), Expect = 9.8
Identities = 32/138 (23%), Positives = 53/138 (38%), Gaps = 18/138 (13%)
Query: 1267 GNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQ 1326
G GR A + + S+ + EE+ + T+ + +D C
Sbjct: 1323 GRGRARLKSTASSIETLVVADIDSSPSKEEEEEDDDTMQNTVVLFSNTDKFVLMQDMCVV 1382
Query: 1327 CGD-----GGELVMCDKKDCPKAYHLLCLN--LTQPPYGK-WEC-PWHQCDECSSAA--- 1374
CG G L+ C + C + YH C+N +T+ K W C C+ C A+
Sbjct: 1383 CGSFGRGAEGHLLACSQ--CSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPS 1440
Query: 1375 -VSFCEFCP---HSFCKD 1388
+ C+ C H++C D
Sbjct: 1441 RLLLCDDCDISYHTYCLD 1458
Score = 30.8 bits (68), Expect = 9.8
Identities = 15/58 (25%), Positives = 24/58 (41%)
Query: 97 ANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIK 154
A GF A P H+++P+ +P + P PS + P+ G P +K
Sbjct: 2491 AGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLK 2548
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
1 [Homo sapiens]
Length = 1298
Score = 77.8 bits (190), Expect = 7e-14
Identities = 62/193 (32%), Positives = 89/193 (46%), Gaps = 22/193 (11%)
Query: 1119 LQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGEL 1178
L +EC+ C C+N+ L ++ +T GWG+R+ + I G FV EYVGEL
Sbjct: 1101 LIFECN-HACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGEL 1159
Query: 1179 IDEEECRLRIKRAHENSVTNFYMLTVTKD---RIIDAGPKGNYSRFMNHSCNPN-CETQK 1234
I + E +R + ++ + N KD IDA GN SRF+NH C PN +
Sbjct: 1160 ISDSEADVREEDSYLFDLDN-------KDGEVYCIDARFYGNVSRFINHHCEPNLVPVRV 1212
Query: 1235 WTVNGDV---RVGLFALCDIPAGMELTFNYN---LDCLGNGRTECHCGADNC---SGFLG 1285
+ + D+ R+ F+ I AG +L F+Y D G C CG+ C S L
Sbjct: 1213 FMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGK-LFSCRCGSPKCRHSSAALA 1271
Query: 1286 VRPKSACASTNEE 1298
R SA E+
Sbjct: 1272 QRQASAAQEAQED 1284
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 77.4 bits (189), Expect = 9e-14
Identities = 47/137 (34%), Positives = 70/137 (51%), Gaps = 2/137 (1%)
Query: 1149 IIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDR 1208
+ ++ G GL KR+I GE V EY G +I R ++ ++ YM +
Sbjct: 2579 VYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKR-EKFYDGKGIGCYMFRMDDFD 2637
Query: 1209 IIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCL-G 1267
++DA GN +RF+NHSC PNC ++ V G + +FAL I G ELT++Y
Sbjct: 2638 VVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDA 2697
Query: 1268 NGRTECHCGADNCSGFL 1284
+ + C+CGA C FL
Sbjct: 2698 SNKLPCNCGAKRCRRFL 2714
>gi|4504191 mutS homolog 6 [Homo sapiens]
Length = 1360
Score = 75.9 bits (185), Expect = 3e-13
Identities = 49/157 (31%), Positives = 74/157 (47%), Gaps = 11/157 (7%)
Query: 264 TGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVH 323
T F GDLVW+K+ YPWWPC+V + P + + R HVQFF + P R WV
Sbjct: 86 TSCDFSPGDLVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVR-VHVQFFDDSPTRGWVS 144
Query: 324 EKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKAL---- 379
++ ++ Y G K EA K +S K +I + + + A I E A+
Sbjct: 145 KRLLKPYTGSKS-----KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKRLELAVCDEP 199
Query: 380 -KMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTE 415
+ EE +E T DK E+ ++++ V KT+
Sbjct: 200 SEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQ 236
Score = 31.6 bits (70), Expect = 5.8
Identities = 28/106 (26%), Positives = 43/106 (40%), Gaps = 10/106 (9%)
Query: 963 IVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEG 1022
+VW K+ Y WWP + N I+ + FF S WV + + PY G
Sbjct: 95 LVWAKMEGYPWWPCLVYNHPFDGTFIREKGKSVRVHVQFFDDSPTRGWVSKRLLKPYT-G 153
Query: 1023 DKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSR 1068
KS K +K + + + L+A + + EAL +K R
Sbjct: 154 SKS---------KEAQKGGHFYSAKPEILRAMQRADEALNKDKIKR 190
>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
sapiens]
Length = 4911
Score = 75.5 bits (184), Expect = 3e-13
Identities = 43/133 (32%), Positives = 68/133 (51%), Gaps = 2/133 (1%)
Query: 1149 IIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDR 1208
+ ++ +G GL R I+K V EY+G +I E R ++ +E+ YM + D
Sbjct: 4775 LARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVAN-RKEKLYESQNRGVYMFRMDNDH 4833
Query: 1209 IIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGN 1268
+IDA G +R++NHSC PNC + T ++ + + I G EL ++Y D +
Sbjct: 4834 VIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDD 4893
Query: 1269 -GRTECHCGADNC 1280
+ CHCGA NC
Sbjct: 4894 QHKIPCHCGAVNC 4906
Score = 60.5 bits (145), Expect = 1e-08
Identities = 43/138 (31%), Positives = 62/138 (44%), Gaps = 16/138 (11%)
Query: 698 SKKDTVCQICESSGDSLIP--CEGECCKHFHLECLGLASLPDSK--FICMECKTGQHPCF 753
SK+D C +C+S GD L C C +H+H CL +A P + + C ECK C
Sbjct: 338 SKEDANCAVCDSPGDLLDQFFCT-TCGQHYHGMCLDIAVTPLKRAGWQCPECKV----CQ 392
Query: 754 SCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQ-HCCSACSMEKDIHKAS 812
+CK SG+D K C K YH C++ ++ + G++C C C ++S
Sbjct: 393 NCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSV-PTNGWKCKNCRICIECGT-----RSS 446
Query: 813 KGRMMRCLRCPVAYHSGD 830
CL C Y D
Sbjct: 447 SQWHHNCLICDNCYQQQD 464
Score = 43.1 bits (100), Expect = 0.002
Identities = 23/71 (32%), Positives = 35/71 (49%), Gaps = 6/71 (8%)
Query: 759 GKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQ-HCCSACSMEKDIHKASKGRMM 817
G + + + CG+ YH CV T + SKG+RC + C AC D GR++
Sbjct: 969 GAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATD-----PGRLL 1023
Query: 818 RCLRCPVAYHS 828
C C ++YH+
Sbjct: 1024 LCDDCDISYHT 1034
Score = 41.2 bits (95), Expect = 0.007
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 9/64 (14%)
Query: 1324 CFQCG---DGGELVMCDKKDCPKAYHLLCLN--LTQPPYGKWECPW-HQCDECSSAAVSF 1377
C CG D G L++CD DC +YH CL+ L P G W+C W C C + +
Sbjct: 1010 CEACGKATDPGRLLLCD--DCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGL 1067
Query: 1378 -CEF 1380
CE+
Sbjct: 1068 RCEW 1071
Score = 39.7 bits (91), Expect = 0.021
Identities = 24/92 (26%), Positives = 35/92 (38%), Gaps = 23/92 (25%)
Query: 1324 CFQCGDGGELVMCDKKDCPKAYHLLCLN--LTQPPYGKWECP---------------WH- 1365
C Q G+ ++++CD C K YH CL + P W+C WH
Sbjct: 394 CKQSGEDSKMLVCDT--CDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWHH 451
Query: 1366 ---QCDECSSAAVSFCEFCPHSFCKDHEKGAL 1394
CD C + C FC + + +K L
Sbjct: 452 NCLICDNCYQQQDNLCPFCGKCYHPELQKDML 483
Score = 36.6 bits (83), Expect = 0.18
Identities = 50/219 (22%), Positives = 77/219 (35%), Gaps = 40/219 (18%)
Query: 771 GKFYHEACVRKFPTAI-----FESKG-----FRCPQHCCSACSMEK----DIHKAS-KGR 815
GK + E + P AI F+S G RC + C ME+ ++ KA G
Sbjct: 222 GKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQMEEPLLVNVDKAVVSGS 281
Query: 816 MMRCL--------------RCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVN 861
RC +C YH A A S L+C H ++ S +
Sbjct: 282 TERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKED 341
Query: 862 VGFCFVCARGLIVQDHSDPMF-SSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKG 920
C VC D D F ++ H + + L + + C++
Sbjct: 342 AN-CAVCDSP---GDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQS 397
Query: 921 G---RLLCCESCPASFHPECLSIEM---PEGCWNCNDCK 953
G ++L C++C +H CL M P W C +C+
Sbjct: 398 GEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCR 436
Score = 36.2 bits (82), Expect = 0.23
Identities = 16/40 (40%), Positives = 20/40 (50%), Gaps = 3/40 (7%)
Query: 916 KCEKGGRLLCCESCPASFHPECLSIEM---PEGCWNCNDC 952
K GRLL C+ C S+H CL + P+G W C C
Sbjct: 1015 KATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWC 1054
Score = 34.7 bits (78), Expect = 0.68
Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 4/36 (11%)
Query: 921 GRLLCCESCPASFHPECLSIEMPEGC----WNCNDC 952
GRLL C C +HP C+SI++ + W C +C
Sbjct: 972 GRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLEC 1007
Score = 34.3 bits (77), Expect = 0.89
Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 20/91 (21%)
Query: 1312 IKTEPKQMHEDY-CFQCGDGGELV---MCDKKDCPKAYHLLCLNLTQPPYGK--WECPWH 1365
I P++ ED C C G+L+ C C + YH +CL++ P + W+CP
Sbjct: 331 IDQAPERSKEDANCAVCDSPGDLLDQFFCTT--CGQHYHGMCLDIAVTPLKRAGWQCP-- 386
Query: 1366 QCDECSSAAVS-------FCEFCP---HSFC 1386
+C C + S C+ C H+FC
Sbjct: 387 ECKVCQNCKQSGEDSKMLVCDTCDKGYHTFC 417
Score = 32.0 bits (71), Expect = 4.4
Identities = 27/115 (23%), Positives = 50/115 (43%), Gaps = 18/115 (15%)
Query: 1290 SACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGE-----LVMCDKKDCPKA 1344
+A S+N++ +N+ ++ +++D C CG G+ L+ C + C +
Sbjct: 926 TADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQ--CGQC 983
Query: 1345 YHLLC--LNLTQPPYGK-WEC-PWHQCDECSSAA----VSFCEFCP---HSFCKD 1388
YH C + +T+ K W C C+ C A + C+ C H++C D
Sbjct: 984 YHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLD 1038
>gi|24308089 chromodomain helicase DNA binding protein 5 [Homo
sapiens]
Length = 1954
Score = 67.0 bits (162), Expect = 1e-10
Identities = 41/118 (34%), Positives = 58/118 (49%), Gaps = 23/118 (19%)
Query: 1289 KSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLL 1348
+S C++ +K+K + K+KR + H+DYC C GGE+++CD CP+AYHL+
Sbjct: 312 RSECSAALGKKSKRRR-KKKRIDDGDGYETDHQDYCEVCQQGGEIILCD--TCPRAYHLV 368
Query: 1349 CLN--LTQPPYGKWECP--------WHQCDE--------CSSAAVSFCEFCPHSFCKD 1388
CL+ L + P GKW CP W D+ C EFC CKD
Sbjct: 369 CLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDDHMEFC--RVCKD 424
Score = 55.1 bits (131), Expect = 5e-07
Identities = 26/55 (47%), Positives = 33/55 (60%), Gaps = 4/55 (7%)
Query: 1315 EPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLN--LTQPPYGKWECPWHQC 1367
E + H ++C C DGGEL+ CD CP +YHL CLN L + P G+W CP C
Sbjct: 410 EEEDDHMEFCRVCKDGGELLCCDA--CPSSYHLHCLNPPLPEIPNGEWLCPRCTC 462
Score = 48.1 bits (113), Expect = 6e-05
Identities = 19/39 (48%), Positives = 26/39 (66%), Gaps = 3/39 (7%)
Query: 917 CEKGGRLLCCESCPASFHPECLS---IEMPEGCWNCNDC 952
C+ GG LLCC++CP+S+H CL+ E+P G W C C
Sbjct: 422 CKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRC 460
Score = 45.8 bits (107), Expect = 3e-04
Identities = 16/40 (40%), Positives = 27/40 (67%), Gaps = 3/40 (7%)
Query: 917 CEKGGRLLCCESCPASFHPECLSIEM---PEGCWNCNDCK 953
C++GG ++ C++CP ++H CL E+ PEG W+C C+
Sbjct: 349 CQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCE 388
Score = 33.5 bits (75), Expect = 1.5
Identities = 22/78 (28%), Positives = 38/78 (48%)
Query: 133 PPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHES 192
P P S+P+ PKK + K K K + EL E+ + +E + S+++ +K +
Sbjct: 41 PVEPVSLPKKKKPKKLKENKCKGKRKKKEGSNDELSENEEDLEEKSESEGSDYSPNKKKK 100
Query: 193 RKEKRKKSNKHDSSRSEE 210
+K K KK K + +E
Sbjct: 101 KKLKDKKEKKAKRKKKDE 118
>gi|51599156 chromodomain helicase DNA binding protein 4 [Homo
sapiens]
Length = 1912
Score = 63.5 bits (153), Expect = 1e-09
Identities = 30/80 (37%), Positives = 45/80 (56%), Gaps = 12/80 (15%)
Query: 1294 STNEEKAKNAKLKQKRRKIKTEPKQM--------HEDYCFQCGDGGELVMCDKKDCPKAY 1345
ST+ KL+ ++K K E + H+DYC C GGE+++CD CP+AY
Sbjct: 335 STSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDYCEVCQQGGEIILCD--TCPRAY 392
Query: 1346 HLLCL--NLTQPPYGKWECP 1363
H++CL ++ + P GKW CP
Sbjct: 393 HMVCLDPDMEKAPEGKWSCP 412
Score = 53.9 bits (128), Expect = 1e-06
Identities = 25/55 (45%), Positives = 32/55 (58%), Gaps = 4/55 (7%)
Query: 1315 EPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLN--LTQPPYGKWECPWHQC 1367
E H ++C C DGGEL+ CD CP +YH+ CLN L + P G+W CP C
Sbjct: 443 EEDDHHMEFCRVCKDGGELLCCD--TCPSSYHIHCLNPPLPEIPNGEWLCPRCTC 495
Score = 48.9 bits (115), Expect = 3e-05
Identities = 23/54 (42%), Positives = 32/54 (59%), Gaps = 5/54 (9%)
Query: 917 CEKGGRLLCCESCPASFHPECLS---IEMPEGCWNCN--DCKAGKKLHYKQIVW 965
C+ GG LLCC++CP+S+H CL+ E+P G W C C A K K ++W
Sbjct: 455 CKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTCPALKGKVQKILIW 508
Score = 46.2 bits (108), Expect = 2e-04
Identities = 16/40 (40%), Positives = 27/40 (67%), Gaps = 3/40 (7%)
Query: 917 CEKGGRLLCCESCPASFHPECLSIEM---PEGCWNCNDCK 953
C++GG ++ C++CP ++H CL +M PEG W+C C+
Sbjct: 376 CQQGGEIILCDTCPRAYHMVCLDPDMEKAPEGKWSCPHCE 415
Score = 33.1 bits (74), Expect = 2.0
Identities = 58/258 (22%), Positives = 99/258 (38%), Gaps = 64/258 (24%)
Query: 594 VPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMT---SSAYRDT 650
VP +K K ++ + P A K KG+ + D+ KP K + A +++ S R +
Sbjct: 255 VPIRKAKTKEGKG-PNARRKP---KGSPRVPDAKKP-KPKKVAPLKIKLGGFGSKRKRSS 309
Query: 651 SDSDSRGLSDLQVGFGKQVDSPSATADA-DVSDVQSMDSSLSRRGTGMSKK--------- 700
S+ D DL V + D A+ ++ VSD + SS SR+ +KK
Sbjct: 310 SEDD-----DLDV----ESDFDDASINSYSVSDGSTSRSSRSRKKLRTTKKKKKGEEEVT 360
Query: 701 ---------DTVCQICESSGDSLIPCEGECCKHFHLECLG--LASLPDSKFICMECKTGQ 749
C++C+ G+ +I C+ C + +H+ CL + P+ K+ C C+ +
Sbjct: 361 AVDGYETDHQDYCEVCQQGGE-IILCD-TCPRAYHMVCLDPDMEKAPEGKWSCPHCEK-E 417
Query: 750 HPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIH 809
+ K + + G E H C + KD
Sbjct: 418 GIQWEAKEDNSEGEEILEEVGGDLEEE------------------DDHHMEFCRVCKD-- 457
Query: 810 KASKGRMMRCLRCPVAYH 827
G ++ C CP +YH
Sbjct: 458 ---GGELLCCDTCPSSYH 472
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,805,823
Number of Sequences: 37866
Number of extensions: 3159157
Number of successful extensions: 27175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 532
Number of HSP's that attempted gapping in prelim test: 21728
Number of HSP's gapped (non-prelim): 5085
length of query: 1437
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1322
effective length of database: 13,892,928
effective search space: 18366450816
effective search space used: 18366450816
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.