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Search of human proteins with 6912352
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912352 eukaryotic translation initiation factor 2C, 1 [Homo
sapiens]
(857 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912352 eukaryotic translation initiation factor 2C, 1 [Homo ... 1756 0.0
gi|29294647 eukaryotic translation initiation factor 2C, 3 isofo... 1501 0.0
gi|29029593 eukaryotic translation initiation factor 2C, 4 [Homo... 1475 0.0
gi|29171734 eukaryotic translation initiation factor 2C, 2 [Homo... 1473 0.0
gi|29337286 eukaryotic translation initiation factor 2C, 3 isofo... 1174 0.0
gi|221316711 piwi-like 4 [Homo sapiens] 172 2e-42
gi|66346725 piwi-like 1 [Homo sapiens] 164 2e-40
gi|209180418 piwi-like 2 [Homo sapiens] 157 3e-38
gi|24431985 piwi-like 2 [Homo sapiens] 157 3e-38
gi|153792298 piwi-like 3 [Homo sapiens] 147 3e-35
gi|169217928 PREDICTED: similar to piwi like homolog 2 [Homo sap... 60 7e-09
gi|114326455 chromodomain helicase DNA binding protein 8 [Homo s... 32 3.3
gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein [... 31 5.6
gi|169179422 PREDICTED: hypothetical protein [Homo sapiens] 30 7.3
gi|114199473 vacuolar protein sorting 41 isoform 2 [Homo sapiens] 30 7.3
gi|114199475 vacuolar protein sorting 41 isoform 1 [Homo sapiens] 30 7.3
>gi|6912352 eukaryotic translation initiation factor 2C, 1 [Homo
sapiens]
Length = 857
Score = 1756 bits (4547), Expect = 0.0
Identities = 857/857 (100%), Positives = 857/857 (100%)
Query: 1 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 60
MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK
Sbjct: 1 MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIK 60
Query: 61 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 120
PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE
Sbjct: 61 PDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 120
Query: 121 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 180
GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF
Sbjct: 121 GKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFF 180
Query: 181 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 240
SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN
Sbjct: 181 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 240
Query: 241 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 300
IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ
Sbjct: 241 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 300
Query: 301 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 360
TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS
Sbjct: 301 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 360
Query: 361 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG 420
TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG
Sbjct: 361 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG 420
Query: 421 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG 480
RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG
Sbjct: 421 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG 480
Query: 481 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM 540
MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM
Sbjct: 481 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM 540
Query: 541 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP 600
ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP
Sbjct: 541 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP 600
Query: 601 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT 660
AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT
Sbjct: 601 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT 660
Query: 661 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE 720
RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE
Sbjct: 661 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE 720
Query: 721 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL 780
RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL
Sbjct: 721 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL 780
Query: 781 TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL 840
TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL
Sbjct: 781 TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL 840
Query: 841 AKAVQVHQDTLRTMYFA 857
AKAVQVHQDTLRTMYFA
Sbjct: 841 AKAVQVHQDTLRTMYFA 857
>gi|29294647 eukaryotic translation initiation factor 2C, 3 isoform
a [Homo sapiens]
Length = 860
Score = 1501 bits (3887), Expect = 0.0
Identities = 726/864 (84%), Positives = 786/864 (90%), Gaps = 18/864 (2%)
Query: 3 AGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPD 62
AGP+GA Q + PRRPG GT+GKPIKLLAN F+V+IPKIDVY YEVDIKPD
Sbjct: 6 AGPAGA---------QPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPD 56
Query: 63 KCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEG- 121
KCPRRVNREVV+ MVQHFK IFGDR+PVYDGK+++YT LP+ VD +VT+PGEG
Sbjct: 57 KCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGG 116
Query: 122 KDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLE--------SVQALDVAMRHLASMRYT 173
KDR FKVSIK+++ VSW +LHE L +P PLE V A+DV +RHL SM+YT
Sbjct: 117 KDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYT 176
Query: 174 PVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMC 233
PVGRSFFS PEGY HPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVI+FMC
Sbjct: 177 PVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMC 236
Query: 234 EVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFP 293
EVLDI NIDEQP+PLTDS RV+FTKEIKGLKVEVTHCG M+RKYRVCNVTRRPASHQTFP
Sbjct: 237 EVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFP 296
Query: 294 LQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK 353
LQLE+GQTVE TVAQYF++KY LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK
Sbjct: 297 LQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKK 356
Query: 354 LTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPA 413
LTDNQTSTMIKATARSAPDRQEEISRL+++A+Y DP++QEF KV+D+M VTGRVLPA
Sbjct: 357 LTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPA 416
Query: 414 PILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLR 473
P+LQYGGRNR +ATP+ GVWDMRGKQF+ G+EIK+WAIACFA Q+QCREE+LK FTDQLR
Sbjct: 417 PMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLR 476
Query: 474 KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRV 533
KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRV
Sbjct: 477 KISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRV 536
Query: 534 GDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLG 593
GDTLLGMATQCVQVKNV+KTSPQTLSNLCLKINVKLGGINNILVPHQR +VFQQPVIFLG
Sbjct: 537 GDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLG 596
Query: 594 ADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYK 653
ADVTHPPAGDGKKPSI AVVGSMDAHPSRYCATVRVQRPRQEII+DL+ MVRELLIQFYK
Sbjct: 597 ADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYK 656
Query: 654 STRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRL 713
STRFKPTRIIFYRDGV EGQ Q+L+YELLAIR+ACI LEKDYQPGITYIVVQKRHHTRL
Sbjct: 657 STRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRL 716
Query: 714 FCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFT 773
FCAD+ ER+G+SGNIPAGTTVDT+ITHP+EFDFYLCSHAGIQGTSRPSHY+VLWDDN FT
Sbjct: 717 FCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFT 776
Query: 774 ADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSN 833
ADELQ+LTYQLCHTYVRCTRSVSIPAPAYYA LVAFRARYHLVDKEHDS EGSH+SGQSN
Sbjct: 777 ADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSN 836
Query: 834 GRDPQALAKAVQVHQDTLRTMYFA 857
GRDPQALAKAVQ+HQDTLRTMYFA
Sbjct: 837 GRDPQALAKAVQIHQDTLRTMYFA 860
>gi|29029593 eukaryotic translation initiation factor 2C, 4 [Homo
sapiens]
Length = 861
Score = 1475 bits (3818), Expect = 0.0
Identities = 713/854 (83%), Positives = 778/854 (91%), Gaps = 12/854 (1%)
Query: 16 PLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEY 75
P +FQ PRRPG+GTVGKPI+LLAN+F+V IPKIDVYHY+VDIKP+K PRRVNREVV+
Sbjct: 8 PPASLFQPPRRPGLGTVGKPIRLLANHFQVQIPKIDVYHYDVDIKPEKRPRRVNREVVDT 67
Query: 76 MVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAI 135
MV+HFK QIFGDR+P YDGK+N+YT LPIG +RVD EVT+PGEGKD+ FKVS++W+++
Sbjct: 68 MVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSV 127
Query: 136 VSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGRE 195
VS ++L EAL VP +SVQALDV RHL SMRYTPVGRSFFSPPEGYYHPLGGGRE
Sbjct: 128 VSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGRE 187
Query: 196 VWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVR 255
VWFGFHQSVRPAMW MMLNIDVSATAFY+AQP+IEFMCEVLDI+NI+EQ KPLTDSQRV+
Sbjct: 188 VWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVK 247
Query: 256 FTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYN 315
FTKEI+GLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLE+GQ +ECTVAQYFKQKY+
Sbjct: 248 FTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYS 307
Query: 316 LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQE 375
LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQE
Sbjct: 308 LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQE 367
Query: 376 EISRLMKNASY--NLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVW 433
EISRL+K+ S DPY++EFGI V ++MTE+TGRVLPAP+LQYGGRN+ +ATPNQGVW
Sbjct: 368 EISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVW 427
Query: 434 DMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYA 493
DMRGKQFY GIEIKVWA+ACFAPQKQCRE++LK+FTDQLRKISKDAGMPIQGQPCFCKYA
Sbjct: 428 DMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYA 487
Query: 494 QGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKT 553
QGADSVEPMF+HLK TY GLQLI+VILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKT
Sbjct: 488 QGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKT 547
Query: 554 SPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVV 613
SPQTLSNLCLKIN KLGGINN+LVPHQR +VFQQPVIFLGADVTHPPAGDGKKPSI AVV
Sbjct: 548 SPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVV 607
Query: 614 GSMDAHPSRYCATVRVQRPRQEI----------IEDLSYMVRELLIQFYKSTRFKPTRII 663
GSMD HPSRYCATVRVQ RQEI I+DL+ MVRELLIQFYKSTRFKPTRII
Sbjct: 608 GSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRII 667
Query: 664 FYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIG 723
+YR GV EGQ+ Q+ EL+AIR ACI LE+DY+PGITYIVVQKRHHTRLFCADK ER+G
Sbjct: 668 YYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVG 727
Query: 724 KSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQ 783
KSGN+PAGTTVD+ ITHP EFDFYLCSHAGIQGTSRPSHY VLWDDN FTADELQ+LTYQ
Sbjct: 728 KSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQ 787
Query: 784 LCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKA 843
LCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDK+HDS EGSH+SGQSNGRDPQALAKA
Sbjct: 788 LCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKA 847
Query: 844 VQVHQDTLRTMYFA 857
VQ+H DT TMYFA
Sbjct: 848 VQIHHDTQHTMYFA 861
>gi|29171734 eukaryotic translation initiation factor 2C, 2 [Homo
sapiens]
Length = 859
Score = 1473 bits (3814), Expect = 0.0
Identities = 711/857 (82%), Positives = 787/857 (91%), Gaps = 4/857 (0%)
Query: 3 AGPSGAAAGAYLPPLQ-QVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKP 61
AGP+ A A PP+Q F+ P RP GT G+ IKL AN+FE+DIPKID+YHYE+DIKP
Sbjct: 5 AGPA-LAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKP 63
Query: 62 DKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEG 121
+KCPRRVNRE+VE+MVQHFK QIFGDRKPV+DG+KN+YT LPIG ++V+ EVT+PGEG
Sbjct: 64 EKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEG 123
Query: 122 KDRIFKVSIKWLAIVSWRMLHEALVSGQIP-VPLESVQALDVAMRHLASMRYTPVGRSFF 180
KDRIFKVSIKW++ VS + LH+AL SG++P VP E++QALDV MRHL SMRYTPVGRSFF
Sbjct: 124 KDRIFKVSIKWVSCVSLQALHDAL-SGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFF 182
Query: 181 SPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRN 240
+ EG +PLGGGREVWFGFHQSVRP++WKMMLNIDVSATAFYKAQPVIEF+CEVLD ++
Sbjct: 183 TASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKS 242
Query: 241 IDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQ 300
I+EQ KPLTDSQRV+FTKEIKGLKVE+THCGQMKRKYRVCNVTRRPASHQTFPLQ ESGQ
Sbjct: 243 IEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQ 302
Query: 301 TVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 360
TVECTVAQYFK ++ L L+YPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS
Sbjct: 303 TVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTS 362
Query: 361 TMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGG 420
TMI+ATARSAPDRQEEIS+LM++AS+N DPY++EFGI VKD+MT+VTGRVL P + YGG
Sbjct: 363 TMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGG 422
Query: 421 RNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAG 480
RN+AIATP QGVWDMR KQF+ GIEIKVWAIACFAPQ+QC E LK+FT+QLRKIS+DAG
Sbjct: 423 RNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAG 482
Query: 481 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGM 540
MPIQGQPCFCKYAQGADSVEPMFRHLKNTY+GLQL++VILPGKTPVYAEVKRVGDT+LGM
Sbjct: 483 MPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGM 542
Query: 541 ATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPP 600
ATQCVQ+KNV +T+PQTLSNLCLKINVKLGG+NNIL+P R VFQQPVIFLGADVTHPP
Sbjct: 543 ATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPP 602
Query: 601 AGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPT 660
AGDGKKPSI AVVGSMDAHP+RYCATVRVQ+ RQEII+DL+ MVRELLIQFYKSTRFKPT
Sbjct: 603 AGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPT 662
Query: 661 RIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNE 720
RIIFYRDGV EGQ Q+LH+ELLAIR+ACIKLEKDYQPGIT+IVVQKRHHTRLFC DKNE
Sbjct: 663 RIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNE 722
Query: 721 RIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQIL 780
R+GKSGNIPAGTTVDT ITHP EFDFYLCSHAGIQGTSRPSHY+VLWDDNRF++DELQIL
Sbjct: 723 RVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQIL 782
Query: 781 TYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQAL 840
TYQLCHTYVRCTRSVSIPAPAYYA LVAFRARYHLVDKEHDS EGSH SGQSNGRD QAL
Sbjct: 783 TYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQAL 842
Query: 841 AKAVQVHQDTLRTMYFA 857
AKAVQVHQDTLRTMYFA
Sbjct: 843 AKAVQVHQDTLRTMYFA 859
>gi|29337286 eukaryotic translation initiation factor 2C, 3 isoform
b [Homo sapiens]
Length = 626
Score = 1174 bits (3038), Expect = 0.0
Identities = 561/626 (89%), Positives = 599/626 (95%)
Query: 232 MCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQT 291
MCEVLDI NIDEQP+PLTDS RV+FTKEIKGLKVEVTHCG M+RKYRVCNVTRRPASHQT
Sbjct: 1 MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQT 60
Query: 292 FPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI 351
FPLQLE+GQTVE TVAQYF++KY LQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI
Sbjct: 61 FPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI 120
Query: 352 KKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVL 411
KKLTDNQTSTMIKATARSAPDRQEEISRL+++A+Y DP++QEF KV+D+M VTGRVL
Sbjct: 121 KKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVL 180
Query: 412 PAPILQYGGRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQ 471
PAP+LQYGGRNR +ATP+ GVWDMRGKQF+ G+EIK+WAIACFA Q+QCREE+LK FTDQ
Sbjct: 181 PAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQ 240
Query: 472 LRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVK 531
LRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVK
Sbjct: 241 LRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVK 300
Query: 532 RVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIF 591
RVGDTLLGMATQCVQVKNV+KTSPQTLSNLCLKINVKLGGINNILVPHQR +VFQQPVIF
Sbjct: 301 RVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIF 360
Query: 592 LGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQF 651
LGADVTHPPAGDGKKPSI AVVGSMDAHPSRYCATVRVQRPRQEII+DL+ MVRELLIQF
Sbjct: 361 LGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQF 420
Query: 652 YKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHT 711
YKSTRFKPTRIIFYRDGV EGQ Q+L+YELLAIR+ACI LEKDYQPGITYIVVQKRHHT
Sbjct: 421 YKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHT 480
Query: 712 RLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNR 771
RLFCAD+ ER+G+SGNIPAGTTVDT+ITHP+EFDFYLCSHAGIQGTSRPSHY+VLWDDN
Sbjct: 481 RLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNC 540
Query: 772 FTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQ 831
FTADELQ+LTYQLCHTYVRCTRSVSIPAPAYYA LVAFRARYHLVDKEHDS EGSH+SGQ
Sbjct: 541 FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQ 600
Query: 832 SNGRDPQALAKAVQVHQDTLRTMYFA 857
SNGRDPQALAKAVQ+HQDTLRTMYFA
Sbjct: 601 SNGRDPQALAKAVQIHQDTLRTMYFA 626
>gi|221316711 piwi-like 4 [Homo sapiens]
Length = 852
Score = 172 bits (435), Expect = 2e-42
Identities = 189/801 (23%), Positives = 347/801 (43%), Gaps = 90/801 (11%)
Query: 30 GTVGKPIKLLANYFEVDIPKI-DVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDR 88
G+ G P+KL+ N F +D P+ +Y Y V PD RR+ + + H + ++
Sbjct: 100 GSSGIPVKLVTNLFNLDFPQDWQLYQYHVTYIPDLASRRLR---IALLYSHSE---LSNK 153
Query: 89 KPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDR--IFKVSIKWLAIVSWRMLHEALV 146
+DG A+ +++++ +VT R K++I L L
Sbjct: 154 AKAFDG--------AILFLSQKLEEKVTELSSETQRGETIKMTIT---------LKRELP 196
Query: 147 SGQIPVPLESVQALDVAMRH-LASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVR 205
S PV +Q ++ R L + +GR+F++P E P +W GF SV
Sbjct: 197 SSS-PV---CIQVFNIIFRKILKKLSMYQIGRNFYNPSEPMEIPQHK-LSLWPGFAISVS 251
Query: 206 PAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKV 265
K++ + DVS + + V+EFM + + + K++ GL V
Sbjct: 252 YFERKLLFSADVSYKVL-RNETVLEFMTALCQRTGLSCFTQTCE--------KQLIGLIV 302
Query: 266 EVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPC 325
+ R Y + ++ TF + E T Y+KQ+Y++ + + P
Sbjct: 303 LTRY---NNRTYSIDDIDWSVKPTHTF----QKRDGTEITYVDYYKQQYDITVSDLNQPM 355
Query: 326 L-QVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTST--MIKATAR----SAPDRQEEIS 378
L + +++++ ++ +++ + LTD TS ++KA A S RQ+ ++
Sbjct: 356 LVSLLKKKRNDNSEAQLAHLIPELCFLTGLTDQATSDFQLMKAVAEKTRLSPSGRQQRLA 415
Query: 379 RLMKN------ASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGV 432
RL+ N A + L+ + FG ++ +TGR++P+ + +
Sbjct: 416 RLVDNIQRNTNARFELETWGLHFGSQIS-----LTGRIVPSEKILMQDHICQPVSAADWS 470
Query: 433 WDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKY 492
D+R + N + W I C E V ++F + LR+++ G +
Sbjct: 471 KDIRTCKILNAQSLNTWLILC----SDRTEYVAESFLNCLRRVAGSMGFNVDYPKIIKVQ 526
Query: 493 AQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAE-VKRVGDTLLGMATQCVQVKNVV 551
A V + +++ +QL++ ILP Y + +K+ + + +QCV + +
Sbjct: 527 ENPAAFVRAIQQYVD---PDVQLVMCILPSNQKTYYDSIKKYLSSDCPVPSQCVLARTLN 583
Query: 552 KTSPQT--LSNLCLKINVKLGG-INNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPS 608
K + + +++ KLGG + + +P + ++ +G DV K
Sbjct: 584 KQGMMMSIATKIAMQMTCKLGGELWAVEIP-------LKSLMVVGIDVCKDALS--KDVM 634
Query: 609 ITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDG 668
+ V S++ +R+ + +QR ++ + L + L ++YK P RII YR G
Sbjct: 635 VVGCVASVNPRITRWFSRCILQRTMTDVADCLKVFMTGALNKWYKYNHDLPARIIVYRAG 694
Query: 669 VPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNI 728
V +GQL ++ YE+ + + + + ++ IVV+K+ R F + N + N
Sbjct: 695 VGDGQLKTLIEYEVPQLLSSVAESSSNTSSRLSVIVVRKKCMPRFF-TEMNRTVQ---NP 750
Query: 729 PAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTY 788
P GT VD+ T +DFYL S +GT P++Y V++DDN D +Q LT++LCH Y
Sbjct: 751 PLGTVVDSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQRLTFKLCHLY 810
Query: 789 VRCTRSVSIPAPAYYARLVAF 809
VS+PAP YA + F
Sbjct: 811 YNWPGIVSVPAPCQYAHKLTF 831
>gi|66346725 piwi-like 1 [Homo sapiens]
Length = 861
Score = 164 bits (416), Expect = 2e-40
Identities = 188/806 (23%), Positives = 341/806 (42%), Gaps = 97/806 (12%)
Query: 30 GTVGKPIKLLANYFEVDI-PKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDR 88
G+ G ++L N+F + P+ +Y Y +D P RR+ ++ F+ + +
Sbjct: 106 GSSGIIVRLSTNHFRLTSRPQWALYQYHIDYNPLMEARRLRSALL------FQHEDLIGK 159
Query: 89 KPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSG 148
+DG T+ LP ++ EV + + +++I L +
Sbjct: 160 CHAFDG-----TILFLPKRLQQKVTEVFSKTRNGEDV-RITI-------------TLTNE 200
Query: 149 QIPVPLESVQALDVAMRHLAS-MRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPA 207
P +Q ++ R L M +GR++++P + P +W GF S+
Sbjct: 201 LPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPNDPIDIP-SHRLVIWPGFTTSILQY 259
Query: 208 MWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEV 267
+ML DVS +++ V++FM N Q + ++V +KE+ GL V
Sbjct: 260 ENSIMLCTDVSHKVL-RSETVLDFMF------NFYHQTEEHKFQEQV--SKELIGLVVLT 310
Query: 268 THCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQ 327
+ + YRV ++ TF + E + +Y++++YN ++ P L
Sbjct: 311 KY---NNKTYRVDDIDWDQNPKSTF----KKADGSEVSFLEYYRKQYNQEITDLKQPVL- 362
Query: 328 VGQEQKH----------TYLPLEVCNIVAGQRCIKKLTD------NQTSTMIKATARSAP 371
V Q ++ L E+C + LTD N + T +
Sbjct: 363 VSQPKRRRGPGGTLPGPAMLIPELCYLTG-------LTDKMRNDFNVMKDLAVHTRLTPE 415
Query: 372 DRQEEISRLMK--NASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPN 429
RQ E+ RL+ + + N+ ++++G+ ++ +GR+L + GG+ P
Sbjct: 416 QRQREVGRLIDYIHKNDNVQRELRDWGLSFDSNLLSFSGRILQTEKIHQGGKTFDY-NPQ 474
Query: 430 QGVW--DMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQP 487
W + RG + + W + + +++N L K++ GM ++
Sbjct: 475 FADWSKETRGAPLISVKPLDNWLLIYTRRNYEAANSLIQN----LFKVTPAMGMQMRKAI 530
Query: 488 CFCKYAQGADSVEPMFRHLKNTYSGLQLIIVIL--PGKTPVYAEVKRVGDTLLGMATQCV 545
+ D E R L+ + I+V L + Y +K+ T +QCV
Sbjct: 531 MI----EVDDRTEAYLRVLQQKVTADTQIVVCLLSSNRKDKYDAIKKYLCTDCPTPSQCV 586
Query: 546 QVKNVVK--TSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGD 603
+ + K T + + L++N K+GG R + + V+ +G D H
Sbjct: 587 VARTLGKQQTVMAIATKIALQMNCKMGG------ELWRVDIPLKLVMIVGIDCYHDMTAG 640
Query: 604 GKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRII 663
+ SI V S++ +R+ + Q QE+++ L ++ L + + P+RII
Sbjct: 641 RR--SIAGFVASINEGMTRWFSRCIFQDRGQELVDGLKVCLQAALRAWNSCNEYMPSRII 698
Query: 664 FYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIG 723
YRDGV +GQL +++YE+ D + + Y P +T IVV+KR +TR F G
Sbjct: 699 VYRDGVGDGQLKTLVNYEVPQFLDCLKSIGRGYNPRLTVIVVKKRVNTRFFAQSG----G 754
Query: 724 KSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQ 783
+ N GT +D +T P +DF++ S A G+ P+HY V++D++ D +Q LTY+
Sbjct: 755 RLQNPLPGTVIDVEVTRPEWYDFFIVSQAVRSGSVSPTHYNVIYDNSGLKPDHIQRLTYK 814
Query: 784 LCHTYVRCTRSVSIPAPAYYARLVAF 809
LCH Y + +PAP YA +AF
Sbjct: 815 LCHIYYNWPGVIRVPAPCQYAHKLAF 840
>gi|209180418 piwi-like 2 [Homo sapiens]
Length = 973
Score = 157 bits (398), Expect = 3e-38
Identities = 190/806 (23%), Positives = 345/806 (42%), Gaps = 97/806 (12%)
Query: 30 GTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRK 89
G+ G P L N ++ VY Y V P+ V + + + + + G+
Sbjct: 218 GSKGTPQSLGLNLVKIQCHNEAVYQYHVTFSPN-----VECKSMRFGMLKDHQAVTGN-V 271
Query: 90 PVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQ 149
+DG ++ LP+ ++V + + + K ++SIK I ++L
Sbjct: 272 TAFDG-----SILYLPVKLQQV---LELKSQRKTDSAEISIK---IQMTKILEPC---SD 317
Query: 150 IPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYY---HPLGGGREVWFGFHQSVRP 206
+ +P +V V R + + VGR+F+ P H L ++W G+ S+R
Sbjct: 318 LCIPFYNV----VFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRL----QIWPGYAASIRR 369
Query: 207 AMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKV- 265
+ L DVS VI C VLD+ + Q + F E L V
Sbjct: 370 TDGGLFLLADVS-------HKVIRNDC-VLDVMHAIYQ------QNKEHFQDECTKLLVG 415
Query: 266 EVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPC 325
+ R YR+ +V +F + E T +Y+ + Y + +K P
Sbjct: 416 NIVITRYNNRTYRIDDVDWNKTPKDSFTMS----DGKEITFLEYYSKNYGITVKEEDQPL 471
Query: 326 L---------QVGQEQKHTYLPLEVCNIVAG-QRCIKKLTDNQTSTMIKATARSAPDRQE 375
L G K L L + + G +KK D + + +P +
Sbjct: 472 LIHRPSERQDNHGMLLKGEILLLPELSFMTGIPEKMKK--DFRAMKDLAQQINLSPKQHH 529
Query: 376 E-----ISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQ 430
+ R+ KN + + + +G++++ D+ ++ GRVLP + +N + T +
Sbjct: 530 SALECLLQRIAKNEAATNE--LMRWGLRLQKDVHKIEGRVLPMERINL--KNTSFITSQE 585
Query: 431 GVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFC 490
W + + + I + A F P++ + + + L KI+ GM + P +
Sbjct: 586 LNWVKEVTRDPSILTIPMHFWALFYPKRAMDQA--RELVNMLEKIAGPIGMRMS-PPAWV 642
Query: 491 KYAQGADSVEPMFRHLKNTYSG---LQLIIVILPG-KTPVYAEVKRVGDTLLGMATQCVQ 546
+ D +E R +++T +Q+++ I+ G + +Y +K++ + +Q V
Sbjct: 643 ELKD--DRIETYVRTIQSTLGAEGKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVN 700
Query: 547 VKNVVKTSP--QTLSNLCLKINVKLGG-INNILVPHQRSAVFQQPVIFLGADVTHPPAGD 603
V+ + + + + L+IN KLGG + + +P ++ V +G DV H P+
Sbjct: 701 VRTIGQPTRLRSVAQKILLQINCKLGGELWGVDIPLKQLMV-------IGMDVYHDPSRG 753
Query: 604 GKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRII 663
+ S+ V S++ +++ + V Q P QEI++ L + L +FY+ P +I+
Sbjct: 754 MR--SVVGFVASINLTLTKWYSRVVFQMPHQEIVDSLKLCLVGSLKKFYEVNHCLPEKIV 811
Query: 664 FYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIG 723
YRDGV +GQL + +YE+ ++ C + ++YQP + VVQK+ T L+ A +
Sbjct: 812 VYRDGVSDGQLKTVANYEIPQLQK-CFEAFENYQPKMVVFVVQKKISTNLYLAAPQNFVT 870
Query: 724 KSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQ 783
+ GT VD IT DFYL +H QG P+HY + + + D +Q LT++
Sbjct: 871 PT----PGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFK 926
Query: 784 LCHTYVRCTRSVSIPAPAYYARLVAF 809
LCH Y ++ +PAP YA +AF
Sbjct: 927 LCHMYWNWPGTIRVPAPCKYAHKLAF 952
>gi|24431985 piwi-like 2 [Homo sapiens]
Length = 973
Score = 157 bits (398), Expect = 3e-38
Identities = 190/806 (23%), Positives = 345/806 (42%), Gaps = 97/806 (12%)
Query: 30 GTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRK 89
G+ G P L N ++ VY Y V P+ V + + + + + G+
Sbjct: 218 GSKGTPQSLGLNLVKIQCHNEAVYQYHVTFSPN-----VECKSMRFGMLKDHQAVTGN-V 271
Query: 90 PVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQ 149
+DG ++ LP+ ++V + + + K ++SIK I ++L
Sbjct: 272 TAFDG-----SILYLPVKLQQV---LELKSQRKTDSAEISIK---IQMTKILEPC---SD 317
Query: 150 IPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYY---HPLGGGREVWFGFHQSVRP 206
+ +P +V V R + + VGR+F+ P H L ++W G+ S+R
Sbjct: 318 LCIPFYNV----VFRRVMKLLDMKLVGRNFYDPTSAMVLQQHRL----QIWPGYAASIRR 369
Query: 207 AMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKV- 265
+ L DVS VI C VLD+ + Q + F E L V
Sbjct: 370 TDGGLFLLADVS-------HKVIRNDC-VLDVMHAIYQ------QNKEHFQDECTKLLVG 415
Query: 266 EVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPC 325
+ R YR+ +V +F + E T +Y+ + Y + +K P
Sbjct: 416 NIVITRYNNRTYRIDDVDWNKTPKDSFTMS----DGKEITFLEYYSKNYGITVKEEDQPL 471
Query: 326 L---------QVGQEQKHTYLPLEVCNIVAG-QRCIKKLTDNQTSTMIKATARSAPDRQE 375
L G K L L + + G +KK D + + +P +
Sbjct: 472 LIHRPSERQDNHGMLLKGEILLLPELSFMTGIPEKMKK--DFRAMKDLAQQINLSPKQHH 529
Query: 376 E-----ISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQ 430
+ R+ KN + + + +G++++ D+ ++ GRVLP + +N + T +
Sbjct: 530 SALECLLQRIAKNEAATNE--LMRWGLRLQKDVHKIEGRVLPMERINL--KNTSFITSQE 585
Query: 431 GVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFC 490
W + + + I + A F P++ + + + L KI+ GM + P +
Sbjct: 586 LNWVKEVTRDPSILTIPMHFWALFYPKRAMDQA--RELVNMLEKIAGPIGMRMS-PPAWV 642
Query: 491 KYAQGADSVEPMFRHLKNTYSG---LQLIIVILPG-KTPVYAEVKRVGDTLLGMATQCVQ 546
+ D +E R +++T +Q+++ I+ G + +Y +K++ + +Q V
Sbjct: 643 ELKD--DRIETYVRTIQSTLGAEGKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVN 700
Query: 547 VKNVVKTSP--QTLSNLCLKINVKLGG-INNILVPHQRSAVFQQPVIFLGADVTHPPAGD 603
V+ + + + + L+IN KLGG + + +P ++ V +G DV H P+
Sbjct: 701 VRTIGQPTRLRSVAQKILLQINCKLGGELWGVDIPLKQLMV-------IGMDVYHDPSRG 753
Query: 604 GKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRII 663
+ S+ V S++ +++ + V Q P QEI++ L + L +FY+ P +I+
Sbjct: 754 MR--SVVGFVASINLTLTKWYSRVVFQMPHQEIVDSLKLCLVGSLKKFYEVNHCLPEKIV 811
Query: 664 FYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIG 723
YRDGV +GQL + +YE+ ++ C + ++YQP + VVQK+ T L+ A +
Sbjct: 812 VYRDGVSDGQLKTVANYEIPQLQK-CFEAFENYQPKMVVFVVQKKISTNLYLAAPQNFVT 870
Query: 724 KSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQ 783
+ GT VD IT DFYL +H QG P+HY + + + D +Q LT++
Sbjct: 871 PT----PGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYVCVLNTANLSPDHMQRLTFK 926
Query: 784 LCHTYVRCTRSVSIPAPAYYARLVAF 809
LCH Y ++ +PAP YA +AF
Sbjct: 927 LCHMYWNWPGTIRVPAPCKYAHKLAF 952
>gi|153792298 piwi-like 3 [Homo sapiens]
Length = 882
Score = 147 bits (372), Expect = 3e-35
Identities = 188/816 (23%), Positives = 352/816 (43%), Gaps = 109/816 (13%)
Query: 30 GTVGKPIKLLANYFEV-DIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDR 88
G+ G ++LLAN+F V P+ Y Y VD KPD + +++ QH + FG+R
Sbjct: 119 GSEGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLD---QHRRK--FGER 173
Query: 89 KPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDR-IFKVSIKWLAIVSWRMLHEALVS 147
++DG + + P+ RV++ T KD+ I K+++++ ++
Sbjct: 174 H-IFDGNS---LLLSRPLKERRVEWLSTT----KDKNIVKITVEFSKELT---------- 215
Query: 148 GQIPVPLESVQALDVAMRHLASMR-YTPVGRSFFSPPEG---YYHPLGGGREVWFGFHQS 203
P + ++ ++ R + + VGR++++ + Y H G E+W G+ S
Sbjct: 216 ---PTSPDCLRYYNILFRRTFKLLDFEQVGRNYYTKKKAIQLYRH--GTSLEIWLGYVTS 270
Query: 204 VRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGL 263
V + L DVS + + +F I+ Q + T + R T ++ G
Sbjct: 271 VLQYENSITLCADVSHKLL-RIETAYDF------IKRTSAQAQ--TGNIREEVTNKLIGS 321
Query: 264 KVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHL 323
V + + YRV ++ + TF + T Y++Q++ +
Sbjct: 322 IVLTKY---NNKTYRVDDIDWKQNPEDTF----NKSDGSKITYIDYYRQQHKEIVTVKKQ 374
Query: 324 PCLQ---------VGQEQKHTYLPLEVCNIVAGQRCIKKLTDN--QTSTMIKATA---RS 369
P L G +++ L ++C++ LTD + +++K A R
Sbjct: 375 PLLVSQGRWKKGLTGTQREPILLIPQLCHMTG-------LTDEICKDYSIVKELAKHTRL 427
Query: 370 APDRQ-----EEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRA 424
+P R+ E I+ L N +Q + +K + V GRVL + G R
Sbjct: 428 SPRRRHHTLKEFINTLQDNKKVR--ELLQLWDLKFDTNFLSVPGRVLKNANIVQG--RRM 483
Query: 425 IATPNQGVW--DMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMP 482
+ +QG W ++R N + + W I + E + + L+ ++ G+
Sbjct: 484 VKANSQGDWSREIRELPLLNAMPLHSWLILY---SRSSHREAM-SLKGHLQSVTAPMGIT 539
Query: 483 IQGQPCFCKYAQGADSVEPMFRHLKNTYS-GLQLIIV-----ILPGKTPV-YAEVKRVGD 535
++ ++ + ++ + T G+ ++V ILP Y +KR
Sbjct: 540 MKPAEMIEVDGDANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRRYDSIKRYLC 599
Query: 536 TLLGMATQCVQVKNVVKTSPQTL-SNLCLKINVKLGG-INNILVPHQRSAVFQQPVIFLG 593
T + +QCV K + K +T+ + + ++N K+GG + + QR+ +F+G
Sbjct: 600 TKCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGALWKVETDVQRT-------MFVG 652
Query: 594 ADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYK 653
D H ++ SI V S +A +++ + +Q+ +E++++L ++ L + K
Sbjct: 653 IDCFHDIVN--RQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDVWCK 710
Query: 654 STRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRL 713
+ P +I YRDGV +GQL +L +E + +K + +IVV+KR +TR
Sbjct: 711 NESSMPHSVIVYRDGVGDGQLQALLDHEAKKM-STYLKTISPNNFTLAFIVVKKRINTRF 769
Query: 714 FCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFT 773
F + N P GT +D +T +DF++ S + GT P+HY V++D +
Sbjct: 770 FLKHGSN----FQNPPPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLS 825
Query: 774 ADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAF 809
D +Q LTY LCH Y + +PAP +YA +A+
Sbjct: 826 PDTVQRLTYCLCHMYYNLPGIIRVPAPCHYAHKLAY 861
>gi|169217928 PREDICTED: similar to piwi like homolog 2 [Homo
sapiens]
Length = 349
Score = 60.5 bits (145), Expect = 7e-09
Identities = 62/287 (21%), Positives = 136/287 (47%), Gaps = 25/287 (8%)
Query: 377 ISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMR 436
+ R+ KN + + + +G++++ D+ ++ GRVLP + +N + T + W
Sbjct: 30 LQRIAKNEAATNE--LMRWGLRLQKDVHKIEGRVLPMERINL--KNTSFITSQELNWVKE 85
Query: 437 GKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGA 496
+ + + I + A F P++ + + + L KI+ GM + P + +
Sbjct: 86 VTRDPSILTIPMHFWALFYPKRAMDQA--RELVNMLEKIAGPIGMRMS-PPAWVELKD-- 140
Query: 497 DSVEPMFRHLKNTYSG---LQLIIVILPG-KTPVYAEVKRVGDTLLGMATQCVQVKNVVK 552
D +E R +++T +Q+++ I+ G + +Y +K++ + +Q V V+ + +
Sbjct: 141 DRIETYVRTIQSTLGAEGKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQ 200
Query: 553 TSP--QTLSNLCLKINVKLGG-INNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSI 609
+ + L+IN KLGG + + +P ++ V +G DV H P+ + S+
Sbjct: 201 PTRLRSVAQKILLQINCKLGGELWGVDIPLKQLMV-------IGMDVYHDPSRGMR--SV 251
Query: 610 TAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTR 656
V S++ +++ + V Q P QEI++ L + L +FY++ +
Sbjct: 252 VGFVASINLTLTKWYSRVVFQMPHQEIVDSLKLCLVGSLKKFYEAAQ 298
>gi|114326455 chromodomain helicase DNA binding protein 8 [Homo
sapiens]
Length = 2302
Score = 31.6 bits (70), Expect = 3.3
Identities = 18/76 (23%), Positives = 31/76 (40%), Gaps = 4/76 (5%)
Query: 345 VAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMT 404
V G++ + + + + + D + I + N Y ++ IK+ DD
Sbjct: 260 VVGKKRKRNTSSDNSDVEVMPAQSPREDEESSIQKRRSNRQVKRKKYTEDLDIKITDDEE 319
Query: 405 E----VTGRVLPAPIL 416
E VTG + P PIL
Sbjct: 320 EEEVDVTGPIKPEPIL 335
>gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein
[Homo sapiens]
Length = 890
Score = 30.8 bits (68), Expect = 5.6
Identities = 28/101 (27%), Positives = 41/101 (40%), Gaps = 10/101 (9%)
Query: 21 FQAPRRPGIGTVGKPIKLLANYFEVDIP-KIDVYHYEVDIKPDKCPRRVNREVVEYMVQH 79
+Q P+ P G P +F + IP K D + +D P R + V V
Sbjct: 638 YQPPQNPYYYVDGDP------HFIIQIPEKDDALCFNIDEAPGTVLRLIQDAVTGLTVNG 691
Query: 80 FKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGE 120
QI GD++ D K L I N ++DF+V + E
Sbjct: 692 ---QITGDKRGSPDSKTRKTYFGKLGIANAQMDFQVEVTTE 729
>gi|169179422 PREDICTED: hypothetical protein [Homo sapiens]
Length = 645
Score = 30.4 bits (67), Expect = 7.3
Identities = 17/36 (47%), Positives = 23/36 (63%), Gaps = 2/36 (5%)
Query: 3 AGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKL 38
A + +AAGA LP L V APRRPG T +P+++
Sbjct: 539 AALTDSAAGAELPGL--VPSAPRRPGSATAPRPLRV 572
>gi|114199473 vacuolar protein sorting 41 isoform 2 [Homo sapiens]
Length = 829
Score = 30.4 bits (67), Expect = 7.3
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 623 YCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYEL 682
YCA RPR +II+ LS E+ F+ Y EG+ L Y +
Sbjct: 273 YCA-----RPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEGES---LFY-I 323
Query: 683 LAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNER 721
++ RD + E+D I +++ +K++ L A+ +++
Sbjct: 324 VSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQK 362
>gi|114199475 vacuolar protein sorting 41 isoform 1 [Homo sapiens]
Length = 854
Score = 30.4 bits (67), Expect = 7.3
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 9/99 (9%)
Query: 623 YCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYEL 682
YCA RPR +II+ LS E+ F+ Y EG+ L Y +
Sbjct: 298 YCA-----RPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHLEYSEGES---LFY-I 348
Query: 683 LAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNER 721
++ RD + E+D I +++ +K++ L A+ +++
Sbjct: 349 VSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQK 387
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,250,042
Number of Sequences: 37866
Number of extensions: 1603078
Number of successful extensions: 3033
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3003
Number of HSP's gapped (non-prelim): 19
length of query: 857
length of database: 18,247,518
effective HSP length: 111
effective length of query: 746
effective length of database: 14,044,392
effective search space: 10477116432
effective search space used: 10477116432
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.