Search of human proteins with 6912316

Search of human proteins with 6912316

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6912316 claudin 17 [Homo sapiens]
         (224 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6912316 claudin 17 [Homo sapiens]                                  455   e-128
gi|40788011 claudin 8 [Homo sapiens]                                  271   3e-73
gi|11141861 claudin 9 [Homo sapiens]                                  200   7e-52
gi|4502875 claudin 3 [Homo sapiens]                                   200   7e-52
gi|4502877 claudin 4 [Homo sapiens]                                   196   2e-50
gi|153792768 claudin 6 [Homo sapiens]                                 195   2e-50
gi|10863887 claudin 1 [Homo sapiens]                                  176   2e-44
gi|153792186 claudin 7 [Homo sapiens]                                 174   5e-44
gi|195947374 claudin 5 [Homo sapiens]                                 167   7e-42
gi|195947372 claudin 5 [Homo sapiens]                                 167   7e-42
gi|225703142 claudin 14 [Homo sapiens]                                166   1e-41
gi|21536294 claudin 14 [Homo sapiens]                                 166   1e-41
gi|225703138 claudin 14 [Homo sapiens]                                166   1e-41
gi|6912314 claudin 14 [Homo sapiens]                                  166   1e-41
gi|225703140 claudin 14 [Homo sapiens]                                166   1e-41
gi|183979973 claudin 19 isoform a [Homo sapiens]                      164   4e-41
gi|183979975 claudin 19 isoform b [Homo sapiens]                      164   4e-41
gi|9966781 claudin 2 [Homo sapiens]                                   147   5e-36
gi|7656981 claudin 15 [Homo sapiens]                                  123   1e-28
gi|47716519 claudin 20 [Homo sapiens]                                 113   1e-25
gi|50345279 claudin 18 isoform 2 [Homo sapiens]                       112   2e-25
gi|33598916 claudin 10 isoform a [Homo sapiens]                       111   4e-25
gi|7705961 claudin 18 isoform 1 [Homo sapiens]                        111   4e-25
gi|5921465 claudin 10 isoform b [Homo sapiens]                        110   7e-25
gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]                110   1e-24
gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]                110   1e-24
gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]                107   6e-24
gi|162417973 claudin 22 [Homo sapiens]                                107   8e-24
gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]                    99   4e-21
gi|157820127 claudin-like [Homo sapiens]                               97   1e-20

>gi|6912316 claudin 17 [Homo sapiens]
          Length = 224

 Score =  455 bits (1171), Expect = e-128
 Identities = 224/224 (100%), Positives = 224/224 (100%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV
Sbjct: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
           RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG
Sbjct: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
           TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG
Sbjct: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180

Query: 181 LLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV 224
           LLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV
Sbjct: 181 LLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV 224


>gi|40788011 claudin 8 [Homo sapiens]
          Length = 225

 Score =  271 bits (693), Expect = 3e-73
 Identities = 124/214 (57%), Positives = 159/214 (74%), Gaps = 4/214 (1%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA + L+IAGL LG +GMVGT+A T++PQWRVSAF+ +NI+VFE  WEGLWMNC+RQA +
Sbjct: 1   MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANI 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
           R+QCK Y SLLAL P L+ AR LMC A  +S +A ++ I GMK  +CTG NE+ KA++L 
Sbjct: 61  RMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILL 120

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
           T+G++FI+TG+ VLIPVSW AN IIRDFYN  +++ QKRELG AL+LGW +A VL +GG 
Sbjct: 121 TAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGA 180

Query: 181 LLCGFCCCNRKKQGYRYPVPGYRVP----HTDKR 210
           L C   CCN K   YRY +P +R      HT K+
Sbjct: 181 LFCCVFCCNEKSSSYRYSIPSHRTTQKSYHTGKK 214


>gi|11141861 claudin 9 [Homo sapiens]
          Length = 217

 Score =  200 bits (509), Expect = 7e-52
 Identities = 102/206 (49%), Positives = 144/206 (69%), Gaps = 4/206 (1%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   L++ G+ L  LG +GTL +  LP W+V+AF+G++I+V + +WEGLWM+C+ Q+  
Sbjct: 1   MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
           ++QCK Y SLLALP  L+ ARAL  +A+ L+L+ LL+ I G +   C   +E AKA ++ 
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCV-EDEGAKARIVL 119

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
           T+GV+ +L GI VLIPV WTA+ II+DFYNP +    KRELGA+L+LGWA+AA+L +GGG
Sbjct: 120 TAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGG 179

Query: 181 LLCGFCCCNRKK-QGYRYPVPGYRVP 205
           LLC  C C   + +  R P  GY +P
Sbjct: 180 LLC--CTCPPPQVERPRGPRLGYSIP 203


>gi|4502875 claudin 3 [Homo sapiens]
          Length = 220

 Score =  200 bits (509), Expect = 7e-52
 Identities = 97/202 (48%), Positives = 133/202 (65%), Gaps = 3/202 (1%)

Query: 6   LQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCK 65
           L+I G  L  LG +GT+    LP WRVSAF+GSNII  + +WEGLWMNC+ Q+  ++QCK
Sbjct: 5   LEITGTALAVLGWLGTIVCCALPMWRVSAFIGSNIITSQNIWEGLWMNCVVQSTGQMQCK 64

Query: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125
            Y SLLALP  L+ ARAL+ VA+ L+   LL+ + G +   C   ++ AKA +   +GVL
Sbjct: 65  VYDSLLALPQDLQAARALIVVAILLAAFGLLVALVGAQCTNCV-QDDTAKAKITIVAGVL 123

Query: 126 FILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGF 185
           F+L  +  L+PVSW+AN IIRDFYNP +   QKRE+GA L++GWA+AA+  +GG LLC  
Sbjct: 124 FLLAALLTLVPVSWSANTIIRDFYNPVVPEAQKREMGAGLYVGWAAAALQLLGGALLC-- 181

Query: 186 CCCNRKKQGYRYPVPGYRVPHT 207
           C C  +++ Y      Y  P +
Sbjct: 182 CSCPPREKKYTATKVVYSAPRS 203


>gi|4502877 claudin 4 [Homo sapiens]
          Length = 209

 Score =  196 bits (497), Expect = 2e-50
 Identities = 89/186 (47%), Positives = 132/186 (70%), Gaps = 1/186 (0%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   LQ+ G+ L  LG +  +    LP WRV+AF+GSNI+  + +WEGLWMNC+ Q+  
Sbjct: 1   MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
           ++QCK Y SLLALP  L+ ARAL+ +++ ++ + +L+ + G K   C   +E AKA  + 
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCL-EDESAKAKTMI 119

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
            +GV+F+L G+ V++PVSWTA+ II+DFYNP +  GQKRE+GA+L++GWA++ +L +GGG
Sbjct: 120 VAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGG 179

Query: 181 LLCGFC 186
           LLC  C
Sbjct: 180 LLCCNC 185


>gi|153792768 claudin 6 [Homo sapiens]
          Length = 220

 Score =  195 bits (496), Expect = 2e-50
 Identities = 93/186 (50%), Positives = 133/186 (71%), Gaps = 1/186 (0%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   +QI G+VL  LG V  L +  LP W+V+AF+G++I+V + +WEGLWM+C+ Q+  
Sbjct: 1   MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
           ++QCK Y SLLALP  L+ ARAL  +A+ ++L  LL+ + G K   C    + +KA L+ 
Sbjct: 61  QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKD-SKARLVL 119

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
           TSG++F+++G+  LIPV WTA+ IIRDFYNP +   QKRELGA+L+LGWA++ +L +GGG
Sbjct: 120 TSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGG 179

Query: 181 LLCGFC 186
           LLC  C
Sbjct: 180 LLCCTC 185


>gi|10863887 claudin 1 [Homo sapiens]
          Length = 211

 Score =  176 bits (445), Expect = 2e-44
 Identities = 80/200 (40%), Positives = 123/200 (61%), Gaps = 2/200 (1%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   LQ+ G +L FLG +G + +T LPQWR+ ++ G NI+  + ++EGLWM+C+ Q+  
Sbjct: 1   MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
           ++QCK + SLL L   L+  RALM V + L +IA+ +   GMK ++C   +E  K  +  
Sbjct: 61  QIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAV 120

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
             G +F+L G+ +L+  +W  N I+++FY+P   +  + E G ALF GWA+A++  +GG 
Sbjct: 121 IGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGA 180

Query: 181 LLCGFCCCNRKKQGYRYPVP 200
           LLC  C C RK   Y  P P
Sbjct: 181 LLC--CSCPRKTTSYPTPRP 198


>gi|153792186 claudin 7 [Homo sapiens]
          Length = 211

 Score =  174 bits (441), Expect = 5e-44
 Identities = 82/198 (41%), Positives = 122/198 (61%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   LQ+ G  +  LG VG +A T +PQW++S++ G NII  + +++GLWM+C+ Q+  
Sbjct: 1   MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
            + CK Y S+LAL  AL+  RALM V++ L  +A+ +   GMK  +C G ++  KA +  
Sbjct: 61  MMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAM 120

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
             G++FI+ G+  L+  SW  + I+ DFYNP I    K E G A+F+GWA +A++ +GG 
Sbjct: 121 GGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGA 180

Query: 181 LLCGFCCCNRKKQGYRYP 198
           LL   C  N  K GYR P
Sbjct: 181 LLSCSCPGNESKAGYRVP 198


>gi|195947374 claudin 5 [Homo sapiens]
          Length = 303

 Score =  167 bits (423), Expect = 7e-42
 Identities = 87/221 (39%), Positives = 131/221 (59%), Gaps = 10/221 (4%)

Query: 6   LQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCK 65
           L+I GLVL  +G  G +    LP W+V+AF+  NI+  +  W+GLWM+C+ Q+   +QCK
Sbjct: 91  LEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCK 150

Query: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125
            Y S+LAL   ++ ARAL   AV L+ +AL + + G +   C      AKA +  T GVL
Sbjct: 151 VYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGP-AKARVALTGGVL 209

Query: 126 FILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLC-- 183
           ++  G+  L+P+ W ANI++R+FY+P++ + QK ELGAAL++GWA+ A+L +GG LLC  
Sbjct: 210 YLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLCCG 269

Query: 184 GFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV 224
            + C  R       P   + V ++  RR T        +YV
Sbjct: 270 AWVCTGR-------PDLSFPVKYSAPRRPTATGDYDKKNYV 303


>gi|195947372 claudin 5 [Homo sapiens]
          Length = 303

 Score =  167 bits (423), Expect = 7e-42
 Identities = 87/221 (39%), Positives = 131/221 (59%), Gaps = 10/221 (4%)

Query: 6   LQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCK 65
           L+I GLVL  +G  G +    LP W+V+AF+  NI+  +  W+GLWM+C+ Q+   +QCK
Sbjct: 91  LEILGLVLCLVGWGGLILACGLPMWQVTAFLDHNIVTAQTTWKGLWMSCVVQSTGHMQCK 150

Query: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125
            Y S+LAL   ++ ARAL   AV L+ +AL + + G +   C      AKA +  T GVL
Sbjct: 151 VYDSVLALSTEVQAARALTVSAVLLAFVALFVTLAGAQCTTCVAPGP-AKARVALTGGVL 209

Query: 126 FILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLC-- 183
           ++  G+  L+P+ W ANI++R+FY+P++ + QK ELGAAL++GWA+ A+L +GG LLC  
Sbjct: 210 YLFCGLLALVPLCWFANIVVREFYDPSVPVSQKYELGAALYIGWAATALLMVGGCLLCCG 269

Query: 184 GFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV 224
            + C  R       P   + V ++  RR T        +YV
Sbjct: 270 AWVCTGR-------PDLSFPVKYSAPRRPTATGDYDKKNYV 303


>gi|225703142 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (421), Expect = 1e-41
 Identities = 96/235 (40%), Positives = 135/235 (57%), Gaps = 14/235 (5%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   +Q+ G +L FLGMVGTL TT+LP WR +A VG+NI+      +GLWM C+  +  
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT-GSNERAKAYLL 119
             QC+ Y SLLALP  L+ ARALM ++  LS IA    + GMK  +C  G+  +    +L
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 120 GTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGG 179
           G  G LFIL G+  ++ VSWT N ++++FYNP +  G K E+G AL+LG+ S+++  IGG
Sbjct: 121 G--GTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGG 178

Query: 180 GLLCGFCCCNRKKQGYRYP----------VPGYRVPHTDK-RRNTTMLSKTSTSY 223
            LLC  C      + Y+ P           P Y+ P   K  R  ++ S T + Y
Sbjct: 179 TLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGY 233


>gi|21536294 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (421), Expect = 1e-41
 Identities = 96/235 (40%), Positives = 135/235 (57%), Gaps = 14/235 (5%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   +Q+ G +L FLGMVGTL TT+LP WR +A VG+NI+      +GLWM C+  +  
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT-GSNERAKAYLL 119
             QC+ Y SLLALP  L+ ARALM ++  LS IA    + GMK  +C  G+  +    +L
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 120 GTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGG 179
           G  G LFIL G+  ++ VSWT N ++++FYNP +  G K E+G AL+LG+ S+++  IGG
Sbjct: 121 G--GTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGG 178

Query: 180 GLLCGFCCCNRKKQGYRYP----------VPGYRVPHTDK-RRNTTMLSKTSTSY 223
            LLC  C      + Y+ P           P Y+ P   K  R  ++ S T + Y
Sbjct: 179 TLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGY 233


>gi|225703138 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (421), Expect = 1e-41
 Identities = 96/235 (40%), Positives = 135/235 (57%), Gaps = 14/235 (5%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   +Q+ G +L FLGMVGTL TT+LP WR +A VG+NI+      +GLWM C+  +  
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT-GSNERAKAYLL 119
             QC+ Y SLLALP  L+ ARALM ++  LS IA    + GMK  +C  G+  +    +L
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 120 GTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGG 179
           G  G LFIL G+  ++ VSWT N ++++FYNP +  G K E+G AL+LG+ S+++  IGG
Sbjct: 121 G--GTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGG 178

Query: 180 GLLCGFCCCNRKKQGYRYP----------VPGYRVPHTDK-RRNTTMLSKTSTSY 223
            LLC  C      + Y+ P           P Y+ P   K  R  ++ S T + Y
Sbjct: 179 TLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGY 233


>gi|6912314 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (421), Expect = 1e-41
 Identities = 96/235 (40%), Positives = 135/235 (57%), Gaps = 14/235 (5%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   +Q+ G +L FLGMVGTL TT+LP WR +A VG+NI+      +GLWM C+  +  
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT-GSNERAKAYLL 119
             QC+ Y SLLALP  L+ ARALM ++  LS IA    + GMK  +C  G+  +    +L
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 120 GTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGG 179
           G  G LFIL G+  ++ VSWT N ++++FYNP +  G K E+G AL+LG+ S+++  IGG
Sbjct: 121 G--GTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGG 178

Query: 180 GLLCGFCCCNRKKQGYRYP----------VPGYRVPHTDK-RRNTTMLSKTSTSY 223
            LLC  C      + Y+ P           P Y+ P   K  R  ++ S T + Y
Sbjct: 179 TLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGY 233


>gi|225703140 claudin 14 [Homo sapiens]
          Length = 239

 Score =  166 bits (421), Expect = 1e-41
 Identities = 96/235 (40%), Positives = 135/235 (57%), Gaps = 14/235 (5%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   +Q+ G +L FLGMVGTL TT+LP WR +A VG+NI+      +GLWM C+  +  
Sbjct: 1   MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT-GSNERAKAYLL 119
             QC+ Y SLLALP  L+ ARALM ++  LS IA    + GMK  +C  G+  +    +L
Sbjct: 61  IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL 120

Query: 120 GTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGG 179
           G  G LFIL G+  ++ VSWT N ++++FYNP +  G K E+G AL+LG+ S+++  IGG
Sbjct: 121 G--GTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGG 178

Query: 180 GLLCGFCCCNRKKQGYRYP----------VPGYRVPHTDK-RRNTTMLSKTSTSY 223
            LLC  C      + Y+ P           P Y+ P   K  R  ++ S T + Y
Sbjct: 179 TLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGY 233


>gi|183979973 claudin 19 isoform a [Homo sapiens]
          Length = 224

 Score =  164 bits (416), Expect = 4e-41
 Identities = 85/200 (42%), Positives = 120/200 (60%), Gaps = 2/200 (1%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   LQ+ G  L   G VG +A+T LPQW+ S++ G  II    L+EGLWM+C  Q+  
Sbjct: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
           ++QCK Y SLLAL   +++ARALM VAV L  +A+++ + GMK  +   SN  AK  +  
Sbjct: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
             G LFIL G+  L  VSW A ++ ++F+NP+  +  + E G ALF+GWASA +  +GG 
Sbjct: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180

Query: 181 LLCGFCCCNRKKQGYRYPVP 200
            LC  C C   ++    P P
Sbjct: 181 FLC--CTCPEPERPNSSPQP 198


>gi|183979975 claudin 19 isoform b [Homo sapiens]
          Length = 211

 Score =  164 bits (416), Expect = 4e-41
 Identities = 85/200 (42%), Positives = 120/200 (60%), Gaps = 2/200 (1%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   LQ+ G  L   G VG +A+T LPQW+ S++ G  II    L+EGLWM+C  Q+  
Sbjct: 1   MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLG 120
           ++QCK Y SLLAL   +++ARALM VAV L  +A+++ + GMK  +   SN  AK  +  
Sbjct: 61  QVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAI 120

Query: 121 TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGG 180
             G LFIL G+  L  VSW A ++ ++F+NP+  +  + E G ALF+GWASA +  +GG 
Sbjct: 121 AGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGS 180

Query: 181 LLCGFCCCNRKKQGYRYPVP 200
            LC  C C   ++    P P
Sbjct: 181 FLC--CTCPEPERPNSSPQP 198


>gi|9966781 claudin 2 [Homo sapiens]
          Length = 230

 Score =  147 bits (372), Expect = 5e-36
 Identities = 79/196 (40%), Positives = 114/196 (58%), Gaps = 3/196 (1%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   LQ+ G +LG LG++GTL   LLP W+ S++VG++I+      +GLWM C   +  
Sbjct: 1   MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMK-QVQCTGSNERAKAYLL 119
             QC  YS+LL LP  ++ A+A+M  + A+S +A +I + GM+  V C  S  RAK  + 
Sbjct: 61  ITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQES--RAKDRVA 118

Query: 120 GTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGG 179
              GV FIL G+   IPV+W  + I+RDFY+P +    K E+G AL+LG  S+    I G
Sbjct: 119 VAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAG 178

Query: 180 GLLCGFCCCNRKKQGY 195
            +LC  C   R +  Y
Sbjct: 179 IILCFSCSSQRNRSNY 194


>gi|7656981 claudin 15 [Homo sapiens]
          Length = 228

 Score =  123 bits (308), Expect = 1e-28
 Identities = 76/220 (34%), Positives = 115/220 (52%), Gaps = 12/220 (5%)

Query: 15  FLGMVGTLATTL-LPQ--WRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYSSLL 71
           F+  VG L   + LP   WRVS   G N+I    ++E LW +C   +     C  + S+L
Sbjct: 11  FMATVGLLMLGVTLPNSYWRVSTVHG-NVITTNTIFENLWFSCATDSLGVYNCWEFPSML 69

Query: 72  ALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLFILTGI 131
           AL   ++  RALM  A+ L  + LL+GI G++     G     KA L  T+G L IL GI
Sbjct: 70  ALSGYIQACRALMITAILLGFLGLLLGIAGLRCTNIGGLELSRKAKLAATAGALHILAGI 129

Query: 132 FVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGFCCCN-- 189
             ++ +SW A  I RDF++P ++ G K ELG AL+LGW+++ +  +GG  LC  CCC   
Sbjct: 130 CGMVAISWYAFNITRDFFDP-LYPGTKYELGPALYLGWSASLISILGGLCLCSACCCGSD 188

Query: 190 -----RKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV 224
                  ++ Y+ PV    V  +D+  +++       +YV
Sbjct: 189 EDPAASARRPYQAPVSVMPVATSDQEGDSSFGKYGRNAYV 228


>gi|47716519 claudin 20 [Homo sapiens]
          Length = 219

 Score =  113 bits (283), Expect = 1e-25
 Identities = 72/216 (33%), Positives = 103/216 (47%), Gaps = 6/216 (2%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA   LQ+   +L   G+ G L  TLLP W+V+  V SNII       GLWM+C   +  
Sbjct: 1   MASAGLQLLAFILALSGVSGVLTATLLPNWKVNVDVDSNIITAIVQLHGLWMDCTWYSTG 60

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT--GSNERAKAYL 118
              C    S+L+LP  ++ ARA M +A  LS + +     GMK   CT  G +   K++ 
Sbjct: 61  MFSCALKHSILSLPIHVQAARATMVLACVLSALGICTSTVGMK---CTRLGGDRETKSHA 117

Query: 119 LGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIG 178
               GV F+  GI  LI   W    II +F +  +    K E G A+++G+ SA +LFI 
Sbjct: 118 SFAGGVCFMSAGISSLISTVWYTKEIIANFLDLTVPESNKHEPGGAIYIGFISAMLLFIS 177

Query: 179 GGLLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTT 214
           G + C   C  R  +    P     + +T    N+T
Sbjct: 178 GMIFC-TSCIKRNPEARLDPPTQQPISNTQLENNST 212


>gi|50345279 claudin 18 isoform 2 [Homo sapiens]
          Length = 261

 Score =  112 bits (281), Expect = 2e-25
 Identities = 62/198 (31%), Positives = 105/198 (53%), Gaps = 14/198 (7%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNII-VFERLWEGLWMNCIRQAR 59
           MA    Q  G V+  +G+ G +A T + QW       + +  VF   ++GLW +C+R++ 
Sbjct: 1   MAVTACQGLGFVVSLIGIAGIIAATCMDQWSTQDLYNNPVTAVFN--YQGLWRSCVRESS 58

Query: 60  VRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLL 119
              +C+ Y +LL LP  L+  RALM V + L  I LL+ I  +K ++     + AKA + 
Sbjct: 59  GFTECRGYFTLLGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMT 118

Query: 120 GTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIH-----------IGQKRELGAALFLG 168
            TSG++FI++G+  +  VS  AN+++ +F+    +           +  +   GAALF+G
Sbjct: 119 LTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVG 178

Query: 169 WASAAVLFIGGGLLCGFC 186
           W +  +  IGG ++C  C
Sbjct: 179 WVAGGLTLIGGVMMCIAC 196


>gi|33598916 claudin 10 isoform a [Homo sapiens]
          Length = 226

 Score =  111 bits (278), Expect = 4e-25
 Identities = 67/193 (34%), Positives = 105/193 (54%), Gaps = 7/193 (3%)

Query: 7   QIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKF 66
           QI  LV G  G    +A T   +W+V+    S++I    +++GLWMNC   A     C+ 
Sbjct: 5   QIWALVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGNALGSFHCRP 63

Query: 67  YSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT--GSNERAKAYLLGTSGV 124
           + ++  +   ++  R LM  AV+L     +  + GMK   CT  G +++AKA +   +G+
Sbjct: 64  HFTIFKVAGYIQACRGLMIAAVSLGFFGSIFALFGMK---CTKVGGSDKAKAKIACLAGI 120

Query: 125 LFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCG 184
           +FIL+G+  +   S  AN I  +F++P + + QK ELGAALF+GWA A++  IGG + C 
Sbjct: 121 VFILSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFCF 179

Query: 185 FCCCNRKKQGYRY 197
               N K   Y Y
Sbjct: 180 SISDNNKTPRYTY 192


>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
          Length = 261

 Score =  111 bits (278), Expect = 4e-25
 Identities = 60/192 (31%), Positives = 103/192 (53%), Gaps = 14/192 (7%)

Query: 7   QIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNII-VFERLWEGLWMNCIRQARVRLQCK 65
           Q+   +L  LG+ G +A T +  W       + +  VF+  +EGLW +C+RQ+    +C+
Sbjct: 7   QVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQ--YEGLWRSCVRQSSGFTECR 64

Query: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125
            Y ++L LP  L+  RALM V + L  I LL+ I  +K ++     + AKA +  TSG++
Sbjct: 65  PYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIM 124

Query: 126 FILTGIFVLIPVSWTANIIIRDFYNPAIH-----------IGQKRELGAALFLGWASAAV 174
           FI++G+  +  VS  AN+++ +F+    +           +  +   GAALF+GW +  +
Sbjct: 125 FIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGL 184

Query: 175 LFIGGGLLCGFC 186
             IGG ++C  C
Sbjct: 185 TLIGGVMMCIAC 196


>gi|5921465 claudin 10 isoform b [Homo sapiens]
          Length = 228

 Score =  110 bits (276), Expect = 7e-25
 Identities = 68/199 (34%), Positives = 103/199 (51%), Gaps = 7/199 (3%)

Query: 1   MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARV 60
           MA    +I   ++   G V   +T     W+VS   G+ +I     W  LW  C+  +  
Sbjct: 1   MASTASEIIAFMVSISGWVLVSSTLPTDYWKVSTIDGT-VITTATYWANLWKACVTDSTG 59

Query: 61  RLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT--GSNERAKAYL 118
              CK + S+LAL   ++  R LM  AV+L     +  + GMK   CT  G +++AKA +
Sbjct: 60  VSNCKDFPSMLALDGYIQACRGLMIAAVSLGFFGSIFALFGMK---CTKVGGSDKAKAKI 116

Query: 119 LGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIG 178
              +G++FIL+G+  +   S  AN I  +F++P + + QK ELGAALF+GWA A++  IG
Sbjct: 117 ACLAGIVFILSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIG 175

Query: 179 GGLLCGFCCCNRKKQGYRY 197
           G + C     N K   Y Y
Sbjct: 176 GVIFCFSISDNNKTPRYTY 194


>gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  110 bits (274), Expect = 1e-24
 Identities = 66/183 (36%), Positives = 98/183 (53%), Gaps = 5/183 (2%)

Query: 6   LQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCK 65
           +Q  GL+L FLG + ++ TT LP W+    +  ++   E    GLW  C+ Q  V +QCK
Sbjct: 9   MQSVGLLLSFLGWILSIITTYLPHWKN---LNLDLNEMENWTMGLWQTCVIQEEVGMQCK 65

Query: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125
            + S LALP  L  +R LM ++  L  + LL+   G+  ++   S    K  LL   G+L
Sbjct: 66  DFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGIL 125

Query: 126 FILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKR-ELGAALFLGWASAAVLFIGGGLL-C 183
              +GI  L+PVSW A+  +++F++  +     R E G ALFLGW +   L +GG LL C
Sbjct: 126 SWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLNC 185

Query: 184 GFC 186
             C
Sbjct: 186 AAC 188


>gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  110 bits (274), Expect = 1e-24
 Identities = 66/183 (36%), Positives = 98/183 (53%), Gaps = 5/183 (2%)

Query: 6   LQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCK 65
           +Q  GL+L FLG + ++ TT LP W+    +  ++   E    GLW  C+ Q  V +QCK
Sbjct: 9   MQSVGLLLSFLGWILSIITTYLPHWKN---LNLDLNEMENWTMGLWQTCVIQEEVGMQCK 65

Query: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125
            + S LALP  L  +R LM ++  L  + LL+   G+  ++   S    K  LL   G+L
Sbjct: 66  DFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGIL 125

Query: 126 FILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKR-ELGAALFLGWASAAVLFIGGGLL-C 183
              +GI  L+PVSW A+  +++F++  +     R E G ALFLGW +   L +GG LL C
Sbjct: 126 SWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLNC 185

Query: 184 GFC 186
             C
Sbjct: 186 AAC 188


>gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]
          Length = 220

 Score =  107 bits (268), Expect = 6e-24
 Identities = 64/183 (34%), Positives = 97/183 (53%), Gaps = 5/183 (2%)

Query: 6   LQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCK 65
           +Q  GL+L  LG + ++ TT LP W+    +  ++   E    GLW  C+ Q  V +QCK
Sbjct: 9   MQSVGLLLSLLGWILSIITTYLPHWKN---LNLDLNEMENWTMGLWQTCVIQEEVGMQCK 65

Query: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125
            + S LALP  L  +R LM ++  L  + LL+   G+  ++   S    K  LL   G+L
Sbjct: 66  DFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGIL 125

Query: 126 FILTGIFVLIPVSWTANIIIRDFYNPAI-HIGQKRELGAALFLGWASAAVLFIGGGLL-C 183
              +GI  L+PVSW A+  +++F++  +     + E G ALFLGW +   L +GG LL C
Sbjct: 126 SWASGITALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLNC 185

Query: 184 GFC 186
             C
Sbjct: 186 AAC 188


>gi|162417973 claudin 22 [Homo sapiens]
          Length = 220

 Score =  107 bits (267), Expect = 8e-24
 Identities = 69/212 (32%), Positives = 106/212 (50%), Gaps = 6/212 (2%)

Query: 7   QIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKF 66
           Q+AG+ L  LG V +  T  LP W+    +  ++   E    GLW  C+ Q  V +QCK 
Sbjct: 10  QLAGVSLSLLGWVLSCLTNYLPHWKN---LNLDLNEMENWTMGLWQTCVIQEEVGMQCKD 66

Query: 67  YSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLF 126
           + S LALP  L  +R LM ++  L  + LL+   G+  ++   S    K  LL   G+L 
Sbjct: 67  FDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGILS 126

Query: 127 ILTGIFVLIPVSWTANIIIRDFYNPAI-HIGQKRELGAALFLGWASAAVLFIGGGLL-CG 184
             +G+  L+PVSW A+  +++F++  +     + E G ALFLGW +   L +GG LL C 
Sbjct: 127 WASGVTALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLHCA 186

Query: 185 FCCCNRKKQGYRYPVPGYRVPHTD-KRRNTTM 215
            C  +       Y V   +  H + + RNT +
Sbjct: 187 ACSSHAPLASGHYAVAQTQDHHQELETRNTNL 218


>gi|231569235 claudin 10 isoform a_i1 [Homo sapiens]
          Length = 207

 Score = 98.6 bits (244), Expect = 4e-21
 Identities = 65/193 (33%), Positives = 98/193 (50%), Gaps = 26/193 (13%)

Query: 7   QIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKF 66
           QI  LV G  G    +A T   +W+V+    S++I    +++GLWMNC            
Sbjct: 5   QIWALVSGVGGFGALVAATTSNEWKVTTRA-SSVITATWVYQGLWMNCAGY--------- 54

Query: 67  YSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCT--GSNERAKAYLLGTSGV 124
                     ++  R LM  AV+L     +  + GMK   CT  G +++AKA +   +G+
Sbjct: 55  ----------IQACRGLMIAAVSLGFFGSIFALFGMK---CTKVGGSDKAKAKIACLAGI 101

Query: 125 LFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCG 184
           +FIL+G+  +   S  AN I  +F++P + + QK ELGAALF+GWA A++  IGG + C 
Sbjct: 102 VFILSGLCSMTGCSLYANKITTEFFDP-LFVEQKYELGAALFIGWAGASLCIIGGVIFCF 160

Query: 185 FCCCNRKKQGYRY 197
               N K   Y Y
Sbjct: 161 SISDNNKTPRYTY 173


>gi|157820127 claudin-like [Homo sapiens]
          Length = 229

 Score = 96.7 bits (239), Expect = 1e-20
 Identities = 63/187 (33%), Positives = 93/187 (49%), Gaps = 4/187 (2%)

Query: 6   LQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCK 65
           +Q+ GL+L  LG V +  TT+LPQW+    +   +   E    G+W  C+ +  V   CK
Sbjct: 9   VQLGGLLLSLLGWVCSCVTTILPQWKT---LNLELNEMETWIMGIWEVCVDREEVATVCK 65

Query: 66  FYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVL 125
            + S L+LP  L+ AR LM  +  L L+ LL+   G +  Q        K  L      L
Sbjct: 66  AFESFLSLPQELQVARILMVASHGLGLLGLLLCSFGSECFQFHRIRWVFKRRLGLLGRTL 125

Query: 126 FILTGIFVLIPVSWTANIIIRDFYNPAI-HIGQKRELGAALFLGWASAAVLFIGGGLLCG 184
                   L+PVSW A+  I+DF++ +I  I  + E G AL+LGWA+   L +GG LL  
Sbjct: 126 EASASATTLLPVSWVAHATIQDFWDDSIPDIIPRWEFGGALYLGWAAGIFLALGGLLLIF 185

Query: 185 FCCCNRK 191
             C  ++
Sbjct: 186 SACLGKE 192


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.329    0.142    0.455 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,934,456
Number of Sequences: 37866
Number of extensions: 311596
Number of successful extensions: 891
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 818
Number of HSP's gapped (non-prelim): 42
length of query: 224
length of database: 18,247,518
effective HSP length: 98
effective length of query: 126
effective length of database: 14,536,650
effective search space: 1831617900
effective search space used: 1831617900
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.