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Search of human proteins with 6382071
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
(1096 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens] 2177 0.0
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens] 2143 0.0
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens] 1236 0.0
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 1104 0.0
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 1097 0.0
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens] 1007 0.0
gi|21071077 dishevelled-associated activator of morphogenesis 1 ... 422 e-118
gi|40548415 dishevelled associated activator of morphogenesis 2 ... 386 e-107
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 315 1e-85
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 315 1e-85
gi|119120861 formin-like 3 isoform 2 [Homo sapiens] 270 7e-72
gi|33356148 formin-like 1 [Homo sapiens] 264 3e-70
gi|52485606 formin-like 2 [Homo sapiens] 263 7e-70
gi|119120874 formin-like 3 isoform 1 [Homo sapiens] 255 1e-67
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 189 9e-48
gi|157168329 formin 1 [Homo sapiens] 187 4e-47
gi|160707881 formin 2 [Homo sapiens] 180 7e-45
gi|145309324 FH2 domain containing 1 [Homo sapiens] 172 1e-42
gi|58331242 formin homology 2 domain containing 3 [Homo sapiens] 144 5e-34
gi|118572599 formin homology 2 domain containing 1 [Homo sapiens] 111 4e-24
gi|210032580 SET domain containing 1B [Homo sapiens] 83 2e-15
gi|7706501 WW domain binding protein 11 [Homo sapiens] 82 2e-15
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 81 5e-15
gi|56549694 enabled homolog isoform a [Homo sapiens] 80 1e-14
gi|39930375 enabled homolog isoform b [Homo sapiens] 80 1e-14
gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens] 80 1e-14
gi|153792074 proline rich 12 [Homo sapiens] 80 1e-14
gi|11386183 WAS protein family, member 2 [Homo sapiens] 76 2e-13
gi|91208418 transcription elongation regulator 1 isoform 2 [Homo... 73 1e-12
gi|21327715 transcription elongation regulator 1 isoform 1 [Homo... 73 1e-12
>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
Length = 1096
Score = 2177 bits (5640), Expect = 0.0
Identities = 1096/1096 (100%), Positives = 1096/1096 (100%)
Query: 1 MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT 60
MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT
Sbjct: 1 MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT 60
Query: 61 SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN 120
SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN
Sbjct: 61 SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN 120
Query: 121 EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL 180
EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL
Sbjct: 121 EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL 180
Query: 181 NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAF 240
NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAF
Sbjct: 181 NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAF 240
Query: 241 MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITT 300
MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITT
Sbjct: 241 MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITT 300
Query: 301 AAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT 360
AAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT
Sbjct: 301 AAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT 360
Query: 361 MLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTA 420
MLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTA
Sbjct: 361 MLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTA 420
Query: 421 AENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHL 480
AENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHL
Sbjct: 421 AENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHL 480
Query: 481 IDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQ 540
IDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQ
Sbjct: 481 IDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQ 540
Query: 541 VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLF 600
VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLF
Sbjct: 541 VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLF 600
Query: 601 GGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRV 660
GGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRV
Sbjct: 601 GGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRV 660
Query: 661 KEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIF 720
KEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIF
Sbjct: 661 KEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIF 720
Query: 721 LGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQF 780
LGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQF
Sbjct: 721 LGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQF 780
Query: 781 GVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLV 840
GVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLV
Sbjct: 781 GVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLV 840
Query: 841 GNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEH 900
GNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEH
Sbjct: 841 GNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEH 900
Query: 901 VESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEK 960
VESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEK
Sbjct: 901 VESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEK 960
Query: 961 LSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTR 1020
LSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTR
Sbjct: 961 LSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTR 1020
Query: 1021 RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP 1080
RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP
Sbjct: 1021 RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP 1080
Query: 1081 VVNHPCATRANPRSAT 1096
VVNHPCATRANPRSAT
Sbjct: 1081 VVNHPCATRANPRSAT 1096
>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
Length = 1101
Score = 2143 bits (5553), Expect = 0.0
Identities = 1080/1080 (100%), Positives = 1080/1080 (100%)
Query: 1 MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT 60
MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT
Sbjct: 1 MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT 60
Query: 61 SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN 120
SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN
Sbjct: 61 SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN 120
Query: 121 EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL 180
EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL
Sbjct: 121 EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL 180
Query: 181 NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAF 240
NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAF
Sbjct: 181 NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAF 240
Query: 241 MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITT 300
MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITT
Sbjct: 241 MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITT 300
Query: 301 AAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT 360
AAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT
Sbjct: 301 AAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT 360
Query: 361 MLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTA 420
MLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTA
Sbjct: 361 MLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTA 420
Query: 421 AENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHL 480
AENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHL
Sbjct: 421 AENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHL 480
Query: 481 IDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQ 540
IDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQ
Sbjct: 481 IDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQ 540
Query: 541 VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLF 600
VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLF
Sbjct: 541 VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLF 600
Query: 601 GGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRV 660
GGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRV
Sbjct: 601 GGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRV 660
Query: 661 KEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIF 720
KEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIF
Sbjct: 661 KEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIF 720
Query: 721 LGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQF 780
LGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQF
Sbjct: 721 LGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQF 780
Query: 781 GVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLV 840
GVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLV
Sbjct: 781 GVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLV 840
Query: 841 GNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEH 900
GNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEH
Sbjct: 841 GNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEH 900
Query: 901 VESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEK 960
VESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEK
Sbjct: 901 VESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEK 960
Query: 961 LSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTR 1020
LSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTR
Sbjct: 961 LSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTR 1020
Query: 1021 RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP 1080
RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP
Sbjct: 1021 RAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNP 1080
>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
Length = 1193
Score = 1236 bits (3197), Expect = 0.0
Identities = 622/1051 (59%), Positives = 816/1051 (77%), Gaps = 26/1051 (2%)
Query: 35 EEETKNKPKLNIQIKTLADDVRDRITSFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQ-PL 93
EE + +PK ++ I+TL DD+ D+ S R KKE+P + + + + A S+ AA +
Sbjct: 51 EEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPN-LKTAFASSDCSAAPLEM 109
Query: 94 YDERSLNLSEKEVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLK 153
+ LSE E+L+LFEKMMEDMNLNE+KKAPLR KDF+ K+EMV+QYI+ +K+G LK
Sbjct: 110 MENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLK 169
Query: 154 NSKHECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDEL 213
S+ +S QE++HEL+ G +DE+L+ CLESLRVSLTSNPVSWV +FGHEGLGLLLD L
Sbjct: 170 RSRQ---ISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDIL 226
Query: 214 EKLLDKKQQENIDKKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMT 273
EKL+ K QE + KKNQ+K+IQCLKA MN ++GL+RI+ +ERSL LLA+A+DP+ PNMMT
Sbjct: 227 EKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMT 286
Query: 274 EIVKILSAICIVGEENILDKLLGAITTAAERNNRERFSPIVEGLENQEALQLQVACMQFI 333
++VK+LSA+CIVGEE+IL+++L A+T+A E +RF IVEGL + ++QLQVACMQ I
Sbjct: 287 DVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHN-SVQLQVACMQLI 345
Query: 334 NALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSH 393
NALVTSP +LDFR+H+RNEF+R GLK +LP+LK +ND LDIQLKVFDE+KE+DL ELSH
Sbjct: 346 NALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSH 405
Query: 394 RLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECV 453
RL DIRAE+D+ +VY+++++ +K+T AE YF+SILQH LLIRNDY+IR QY+K+I+ECV
Sbjct: 406 RLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECV 465
Query: 454 SQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQE 513
SQIVLH GMDPDF YR+RLD+DLT +D C+++AK+EE E+KA+E KKF++EFT QE
Sbjct: 466 SQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQE 525
Query: 514 AQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPG 573
QAELQK++ KI EL+AE+Q ++Q L + IP PP+ G G PP PPLP
Sbjct: 526 TQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEG--GTGHSALPPPPPLPS 583
Query: 574 GAPLPPPPPPLPGMMGIPPPPPPP---LLFGGPPPPPP----LGGVPPPPGISLNLPYGM 626
G +PPPPPP PPPPP P + F GP PPPP LGG PP LP+G+
Sbjct: 584 GGGVPPPPPP-------PPPPPLPGMRMPFSGPVPPPPPLGFLGGQNSPP--LPILPFGL 634
Query: 627 KQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQK 686
K KK +KPE+SM+R+NW KI P E++ENCFW++V E+K+EN DL KL F Q K ++
Sbjct: 635 KPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKERR 694
Query: 687 NAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEA 746
E +EEKK+ KKK+KEL+ LD K AQNLSIFL S+R+PYE+IR +ILEV+E L+E+
Sbjct: 695 EEEDIEEKKS--IKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAES 752
Query: 747 LIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEH 806
+IQNL+KHLP+Q+ LN L++ K+EY +LCEPEQF VVMS+VK L+PRLS+ILFKL FEE
Sbjct: 753 MIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQ 812
Query: 807 INNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRD 866
+NNIKP I+AV+ ACEE+KKS+SF++LLELVLL+GNYMN+GSRNAQ+ GF ++ LCK++D
Sbjct: 813 VNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKD 872
Query: 867 TKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHL 926
TKSADQKTTLLHF+ +ICEEKY DIL F ++LE ++ ASKVS + L+ NL M +Q+ L
Sbjct: 873 TKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQL 932
Query: 927 ERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTV 986
E++++ FP E+ HDKFV KM+ F +A+EQYE LS +H NM KLY+++ Y+ D K V
Sbjct: 933 EKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKV 992
Query: 987 SIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDI 1046
S+E+F DLNNFRT F++A++EN K+RE EEK +R ++AKE AE+E+LERQ+KKK+L+++
Sbjct: 993 SVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRIAKELAERERLERQQKKKRLLEM 1052
Query: 1047 NKEGDETGVMDNLLEALQSGAAFRDRRKRIP 1077
EGDETGVMDNLLEALQSGAAFRDRRKR P
Sbjct: 1053 KTEGDETGVMDNLLEALQSGAAFRDRRKRTP 1083
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 1104 bits (2856), Expect = 0.0
Identities = 624/1252 (49%), Positives = 808/1252 (64%), Gaps = 189/1252 (15%)
Query: 1 MEQPGAAASGAGGGSEEPGGGRSNKR--SAGNRAANEEETKNKPKLNIQIKTLADDVRDR 58
ME PG + G G G+ + GRS SAG ++ +K L D +R
Sbjct: 1 MEPPGGSL-GPGRGTRDKKKGRSPDELPSAGGDGGKSKK--------FTLKRLMADELER 51
Query: 59 ITSFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMN 118
TS R +KEKP H +S + + P AQ L D +S+++VL LFE+M+ DMN
Sbjct: 52 FTSMRIKK-EKEKPNSAHR-NSSASYGDDPTAQSLQD-----VSDEQVLVLFEQMLLDMN 104
Query: 119 LNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEK 178
LNEEK+ PLR KD KREMV QY+ T+K+G S+ E + S+ Y+ ELRSG+ D
Sbjct: 105 LNEEKQQPLREKDIIIKREMVSQYLY-TSKAG---MSQKESSKSAMMYIQELRSGLRDMP 160
Query: 179 LLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQC 236
LL+CLESLRVSL +NPVSWV FG EGL LLD L++L D+K++ + D +N++++I+C
Sbjct: 161 LLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRC 220
Query: 237 LKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLL 295
LKAFMNNKFG++ +L E +LLL RA+DP PNMM + K+LSA+CI+ + E++ +++L
Sbjct: 221 LKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVL 280
Query: 296 GAITTAAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLR 355
A+T AE + ERF P+++GL++ + L+V C+Q INAL+T ELDFR+H+R+E +R
Sbjct: 281 EAMTERAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMR 340
Query: 356 SGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNM 415
GL +L DL+E EN+++ +QL VFDE E+D +L RL+DIR EMDD NEV+ +L N
Sbjct: 341 LGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNT 400
Query: 416 LKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDI 475
+KD+ AE +FLSILQH LL+RNDY RPQYYK+IEEC+SQIVLH +G DPDFK R L I
Sbjct: 401 VKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRH-LQI 459
Query: 476 DLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKE-------- 527
++ LID ++K KVE+SE KAAE KK D E TAR E Q E++K + ++
Sbjct: 460 EIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGE 519
Query: 528 -----------------LEAEIQQLRTQAQVLS-------------SSSGIPGPPA---- 553
LEAE+ QL + L+ S++ I PP+
Sbjct: 520 KDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSR 579
Query: 554 -----APPLPGVG-------------------PPPPPPAPPLPGGA-------------- 575
APPLPG PPPPPP PPLPGG
Sbjct: 580 APVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAI 639
Query: 576 ----------------PLP-----------------PPPPPLPGMMGIPPPPPP-PLLFG 601
PLP PPPPPLPG IPPPPPP P G
Sbjct: 640 SPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAG 699
Query: 602 GPPPPPPLGG-----------------------------VPPPPGISLN----------- 621
PPPPPPL G PPPPG+ +
Sbjct: 700 IPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPA 759
Query: 622 ---LPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNF 678
LP+G+ KK+YKPEV ++R NWSK+ +LS++CFW +VKED+FEN +LFAKL L F
Sbjct: 760 APVLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTF 819
Query: 679 ATQI---KVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVI 735
+ Q K +K+ E EEKK+ KKKVKEL++LD KTAQNLSIFLGS+RMPY++I+NVI
Sbjct: 820 SAQTKTSKAKKDQEGGEEKKS-VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVI 878
Query: 736 LEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLS 795
LEVNE +L+E++IQNL+K +PE + L L+ELK+EYDDL E EQFGVVM +V L+PRL+
Sbjct: 879 LEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLN 938
Query: 796 SILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLG 855
+ILFKL F E + NIKP I++VT ACEEL+KSESF+ LLE+ LLVGNYMN+GSRNA + G
Sbjct: 939 AILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFG 998
Query: 856 FKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSN 915
F I+FLCK+RDTKS DQK TLLHF+A++CE Y D+LKFP+EL HVE AS+VSA+ L+ N
Sbjct: 999 FNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKN 1058
Query: 916 LASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENL 975
L M++QI +ERD++ FP A ++ DKFVEKMTSF K A+EQY KL MH+NM LY+ L
Sbjct: 1059 LDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKEL 1118
Query: 976 GEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLE 1035
GEYF+FD K +S+EEFF DL+NFR +FL+AV+EN KRRE EEK RRAKLAKEKAE+E+LE
Sbjct: 1119 GEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLE 1178
Query: 1036 RQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNHPCA 1087
+Q+K++QLID+N EGDETGVMD+LLEALQSGAAF RRKR PR CA
Sbjct: 1179 KQQKREQLIDMNAEGDETGVMDSLLEALQSGAAF--RRKRGPRQANRKAGCA 1228
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 1097 bits (2838), Expect = 0.0
Identities = 622/1250 (49%), Positives = 806/1250 (64%), Gaps = 194/1250 (15%)
Query: 1 MEQPGAAASGAGGGSEEPGGGRSNKRSAGNRAANEEETKNKPKLNIQIKTLADDVRDRIT 60
ME PG + G G G+ + GRS +A + K+K L +R T
Sbjct: 1 MEPPGGSL-GPGRGTRDKKKGRSPDELP---SAGGDGGKSKKFL------------ERFT 44
Query: 61 SFRKSTVKKEKPLIQHPIDSQVAMSEFPAAQPLYDERSLNLSEKEVLDLFEKMMEDMNLN 120
S R +KEKP H +S + + P AQ L D +S+++VL LFE+M+ DMNLN
Sbjct: 45 SMRIKK-EKEKPNSAHR-NSSASYGDDPTAQSLQD-----VSDEQVLVLFEQMLLDMNLN 97
Query: 121 EEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLL 180
EEK+ PLR KD KREMV QY+ T+K+G S+ E + S+ Y+ ELRSG+ D LL
Sbjct: 98 EEKQQPLREKDIIIKREMVSQYLY-TSKAG---MSQKESSKSAMMYIQELRSGLRDMPLL 153
Query: 181 NCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQE--NIDKKNQYKLIQCLK 238
+CLESLRVSL +NPVSWV FG EGL LLD L++L D+K++ + D +N++++I+CLK
Sbjct: 154 SCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHEIIRCLK 213
Query: 239 AFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGE-ENILDKLLGA 297
AFMNNKFG++ +L E +LLL RA+DP PNMM + K+LSA+CI+ + E++ +++L A
Sbjct: 214 AFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEA 273
Query: 298 ITTAAERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSG 357
+T AE + ERF P+++GL++ + L+V C+Q INAL+T ELDFR+H+R+E +R G
Sbjct: 274 MTERAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVHIRSELMRLG 333
Query: 358 LKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLK 417
L +L DL+E EN+++ +QL VFDE E+D +L RL+DIR EMDD NEV+ +L N +K
Sbjct: 334 LHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEVFQILLNTVK 393
Query: 418 DTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDL 477
D+ AE +FLSILQH LL+RNDY RPQYYK+IEEC+SQIVLH +G DPDFK R L I++
Sbjct: 394 DSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRH-LQIEI 452
Query: 478 THLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKE---------- 527
LID ++K KVE+SE KAAE KK D E TAR E Q E++K + ++
Sbjct: 453 EGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKD 512
Query: 528 ---------------LEAEIQQLRTQAQVLS-------------SSSGIPGPPA------ 553
LEAE+ QL + L+ S++ I PP+
Sbjct: 513 ALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAP 572
Query: 554 ---APPLPGVG-------------------PPPPPPAPPLPGGA---------------- 575
APPLPG PPPPPP PPLPGG
Sbjct: 573 VPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGTAISP 632
Query: 576 --------------PLP-----------------PPPPPLPGMMGIPPPPPP-PLLFGGP 603
PLP PPPPPLPG IPPPPPP P G P
Sbjct: 633 PPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIP 692
Query: 604 PPPPPLGG-----------------------------VPPPPGISLN------------- 621
PPPPPL G PPPPG+ +
Sbjct: 693 PPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAP 752
Query: 622 -LPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFAT 680
LP+G+ KK+YKPEV ++R NWSK+ +LS++CFW +VKED+FEN +LFAKL L F+
Sbjct: 753 VLPFGLTPKKLYKPEVQLRRPNWSKLVAEDLSQDCFWTKVKEDRFENNELFAKLTLTFSA 812
Query: 681 QI---KVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737
Q K +K+ E EEKK+ KKKVKEL++LD KTAQNLSIFLGS+RMPY++I+NVILE
Sbjct: 813 QTKTSKAKKDQEGGEEKKS-VQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILE 871
Query: 738 VNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSI 797
VNE +L+E++IQNL+K +PE + L L+ELK+EYDDL E EQFGVVM +V L+PRL++I
Sbjct: 872 VNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAI 931
Query: 798 LFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFK 857
LFKL F E + NIKP I++VT ACEEL+KSESF+ LLE+ LLVGNYMN+GSRNA + GF
Sbjct: 932 LFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFN 991
Query: 858 INFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLA 917
I+FLCK+RDTKS DQK TLLHF+A++CE Y D+LKFP+EL HVE AS+VSA+ L+ NL
Sbjct: 992 ISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLD 1051
Query: 918 SMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGE 977
M++QI +ERD++ FP A ++ DKFVEKMTSF K A+EQY KL MH+NM LY+ LGE
Sbjct: 1052 QMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGE 1111
Query: 978 YFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQ 1037
YF+FD K +S+EEFF DL+NFR +FL+AV+EN KRRE EEK RRAKLAKEKAE+E+LE+Q
Sbjct: 1112 YFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKERLEKQ 1171
Query: 1038 KKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNHPCA 1087
+K++QLID+N EGDETGVMD+LLEALQSGAAF RRKR PR CA
Sbjct: 1172 QKREQLIDMNAEGDETGVMDSLLEALQSGAAF--RRKRGPRQANRKAGCA 1219
>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
Length = 849
Score = 1007 bits (2604), Expect = 0.0
Identities = 501/834 (60%), Positives = 655/834 (78%), Gaps = 21/834 (2%)
Query: 251 LGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITTAAERNNRERF 310
+ +ERSL LLA+A+DP+ PNMMT++VK+LSA+CIVGEE+IL+++L A+T+A E +RF
Sbjct: 1 MSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRF 60
Query: 311 SPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKEN 370
IVEGL + ++QLQVACMQ INALVTSP +LDFR+H+RNEF+R GLK +LP+LK +N
Sbjct: 61 FCIVEGLRHN-SVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKN 119
Query: 371 DELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQ 430
D LDIQLKVFDE+KE+DL ELSHRL DIRAE+D+ +VY+++++ +K+T AE YF+SILQ
Sbjct: 120 DGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQ 179
Query: 431 HFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKV 490
H LLIRNDY+IR QY+K+I+ECVSQIVLH GMDPDF YR+RLD+DLT +D C+++AK+
Sbjct: 180 HLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKL 239
Query: 491 EESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPG 550
EE E+KA+E KKF++EFT QE QAELQK++ KI EL+AE+Q ++Q L + IP
Sbjct: 240 EEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPL 299
Query: 551 PPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPP---LLFGGPPPPP 607
PP+ G G PP PPLP G +PPPPPP PPPPP P + F GP PPP
Sbjct: 300 PPSKEG--GTGHSALPPPPPLPSGGGVPPPPPP-------PPPPPLPGMRMPFSGPVPPP 350
Query: 608 P----LGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKED 663
P LGG PP LP+G+K KK +KPE+SM+R+NW KI P E++ENCFW++V E+
Sbjct: 351 PPLGFLGGQNSPP--LPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNEN 408
Query: 664 KFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGS 723
K+EN DL KL F Q K ++ E +EEKK+ KKK+KEL+ LD K AQNLSIFL S
Sbjct: 409 KYENVDLLCKLENTFCCQQKERREEEDIEEKKS--IKKKIKELKFLDSKIAQNLSIFLSS 466
Query: 724 YRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVV 783
+R+PYE+IR +ILEV+E L+E++IQNL+KHLP+Q+ LN L++ K+EY +LCEPEQF VV
Sbjct: 467 FRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVV 526
Query: 784 MSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNY 843
MS+VK L+PRLS+ILFKL FEE +NNIKP I+AV+ ACEE+KKS+SF++LLELVLL+GNY
Sbjct: 527 MSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNY 586
Query: 844 MNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVES 903
MN+GSRNAQ+ GF ++ LCK++DTKSADQKTTLLHF+ +ICEEKY DIL F ++LE ++
Sbjct: 587 MNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDK 646
Query: 904 ASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLST 963
ASKVS + L+ NL M +Q+ LE++++ FP E+ HDKFV KM+ F +A+EQYE LS
Sbjct: 647 ASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSK 706
Query: 964 MHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAK 1023
+H NM KLY+++ Y+ D K VS+E+F DLNNFRT F++A++EN K+RE EEK +R +
Sbjct: 707 LHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVR 766
Query: 1024 LAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIP 1077
+AKE AE+E+LERQ+KKK+L+++ EGDETGVMDNLLEALQSGAAFRDRRKR P
Sbjct: 767 IAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTP 820
>gi|21071077 dishevelled-associated activator of morphogenesis 1 [Homo
sapiens]
Length = 1078
Score = 422 bits (1086), Expect = e-118
Identities = 315/1066 (29%), Positives = 535/1066 (50%), Gaps = 107/1066 (10%)
Query: 79 DSQVAMSEFPAAQPLYDERSLNLSEKEV---LDLFEKMMEDM-NLNEEKKAPL------- 127
DS A+ A P+ L++ E+ LDL +K E M L EKK +
Sbjct: 33 DSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKD 92
Query: 128 --RNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCLES 185
NK T+ E + +++ A L + E +E+ +ES
Sbjct: 93 QEENKGATSWPEFYIDQLNSMAARKSLLALEKE----------------EEEERSKTIES 136
Query: 186 LRVSLTSNPVSWVNNF-GHEGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNK 244
L+ +L + P+ +V F +GL +L+ L+ + E + + LI C+KA MNN
Sbjct: 137 LKTALRTKPMRFVTRFIDLDGLSCILNFLKTM----DYETSESRIHTSLIGCIKALMNNS 192
Query: 245 FGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITTAA 302
G +L S+ ++A+++ + +++IL A+C+V G + +L +L A+
Sbjct: 193 QGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYAS 252
Query: 303 ERNNRERFSPIVEGLEN-----QEALQLQVACMQFINALVTSPY---ELDFRIHLRNEFL 354
ER RF ++ L+ ++ + L+ A M FINA+++ LDFR+HLR EFL
Sbjct: 253 ERT---RFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFL 309
Query: 355 RSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYN 414
G++ ++ L+E EN LD L F+ + +D E + R + + +++ L
Sbjct: 310 MLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRK 369
Query: 415 MLKDTAAENYFLSILQHFLLIRNDYYIRP----QYYKIIEECVSQIVL-HCSGMDPDFKY 469
L + A +F+SIL H L + Y R QY+ +++ + QIV+ + G DPD
Sbjct: 370 RLTHSEAYPHFMSILHHCLQMP---YKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTP 426
Query: 470 RQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDE--------------EFTARQEAQ 515
+ +I +++ VN+ +V++ +++A + K+ +E + ++E
Sbjct: 427 LENFNIK--NVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMM 484
Query: 516 AELQKRDEKIKELEAEIQQLRTQ-AQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGG 574
L K EK+++ E +Q++ Q A + + + +PG GP P P P P
Sbjct: 485 QTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPG-GPSPGAPGGPFPSS 543
Query: 575 AP----LPPPPPPLPGMMGIPPPPPPPLLFGGPPPPP---PLGGVPPPPGISLNLPYGMK 627
P PPPPPPLPG G+ PPPPPPL GGPPPPP PLG + PPPG + L +K
Sbjct: 544 VPGSLLPPPPPPPLPG--GMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGL--ALK 599
Query: 628 QKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDK-FENPDL---------FAKLALN 677
+K + +P ++K NWSK+ +L E W + + K F+ DL + +
Sbjct: 600 KKSIPQPTNALKSFNWSKLPENKL-EGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQDF 658
Query: 678 FATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737
F QK A+A+++ T +K KVKEL ++D + AQN +I L ++ ++I+ IL
Sbjct: 659 FVNSNSKQKEADAIDD--TLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILT 716
Query: 738 VNE-DMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSS 796
++E + L + +++ L+K +PE+ ++ L E K+E D + + ++F MS + Q RL S
Sbjct: 717 MDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQS 776
Query: 797 ILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGF 856
+ FK F E + +KP + A+ EE+ +S + +LLE+VL GNYMN G R + GF
Sbjct: 777 LYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNKGQR-GNAYGF 835
Query: 857 KINFLCKIRDTKSA-DQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSN 915
KI+ L KI DTKS+ D+ TLLH++ I E KY +L EEL + A+KV+ L
Sbjct: 836 KISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKE 895
Query: 916 LASMEQQIVHLERDIK-KFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYEN 974
++++ + +E +++ + Q DKFV ++ F A + + + L+
Sbjct: 896 ISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTK 955
Query: 975 LGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVREN-NKRREMEEKTRRAKLAKEKAEQEK 1033
++F ++ + +EFFG + F EA +EN N R++ EE+ RRA++ + EQ +
Sbjct: 956 AVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRE 1015
Query: 1034 LERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRN 1079
ER+ +K + + +E+G D+L+ AL+SG F ++ RN
Sbjct: 1016 RERKMRKAK-----ENSEESGEFDDLVSALRSGEVFDKDLSKLKRN 1056
>gi|40548415 dishevelled associated activator of morphogenesis 2 [Homo
sapiens]
Length = 1067
Score = 386 bits (991), Expect = e-107
Identities = 308/1062 (29%), Positives = 525/1062 (49%), Gaps = 125/1062 (11%)
Query: 76 HPIDSQVAMSEFPAAQPLYDERSLNLSEK-EVLDLFEKMMEDM-NLNEEKKAPLR----- 128
HP+ EF + P +E ++ +E + LDL +K E M L EKK +
Sbjct: 31 HPLQ----FMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKK 86
Query: 129 -----NKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQEYVHELRSGISDEKLLNCL 183
NK T+ + + I++ A L E T E+R+ + +
Sbjct: 87 EQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEET--------EMRNQV--------V 130
Query: 184 ESLRVSLTSNPVSWVNNFGH-EGLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMN 242
E L+ +L + P+ +V F EGL LL+ L + + + LI C+KA MN
Sbjct: 131 EDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSM----DHATCESRIHTSLIGCIKALMN 186
Query: 243 NKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITT 300
N G +L ++ +A+++ + +++IL A+C+V G + +L +L
Sbjct: 187 NSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQVY 246
Query: 301 AAERNNRERFSPIVEGLEN-----QEALQLQVACMQFINALVTSPY---ELDFRIHLRNE 352
AAER RF ++ L+ ++ + L+ A M FINA++ + L+FR+HLR E
Sbjct: 247 AAERT---RFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYE 303
Query: 353 FLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLL 412
FL G++ ++ L++ EN LD L F+ + +D EL+ R + + + ++++ L+
Sbjct: 304 FLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELI 363
Query: 413 YNMLKDTAAENYFLSILQHFLLI---RNDYYIRPQYYKIIEECVSQIVLHCS-GMDPDFK 468
+ LK T A LS+L H L + RN Y Q +++++ + QIVL G+DPD
Sbjct: 364 HKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYF--QQWQLLDRILQQIVLQDERGVDPDLA 421
Query: 469 YRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDE--------------EFTARQEA 514
+ ++ ++++ +N+ +V++ +A +F K+ E + ++E
Sbjct: 422 PLENFNVK--NIVNMLINENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEM 479
Query: 515 QAELQKRDEKIKELEAEIQQLRTQ-AQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPG 573
L K +K+ E++Q R Q A++++ S + P + P PPP PL
Sbjct: 480 MRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSP--------PPPGGPLTL 531
Query: 574 GAP-----LPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYG--- 625
+ LPPPPPPLP PPPPPPPL GGPP PP G PP G+ L LP
Sbjct: 532 SSSMTTNDLPPPPPPLP-FACCPPPPPPPLPPGGPPTPP---GAPPCLGMGLPLPQDPYP 587
Query: 626 -----MKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDK-FENPDL--FAKLALN 677
+++K++ +P +K NW K+ E W + + + F DL F K+
Sbjct: 588 SSDVPLRKKRVPQPSHPLKSFNWVKLNE-ERVPGTVWNEIDDMQVFRILDLEDFEKM--- 643
Query: 678 FATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILE 737
F+ + QK + E+ +KVKEL ++D + AQN I L ++ E+IR IL+
Sbjct: 644 FSAYQRHQKELGSTEDIYLA--SRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILK 701
Query: 738 VNE-DMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSS 796
++E + L++ +++ L+K +PE+ ++ L E K+E + + ++F MS + Q RL +
Sbjct: 702 MDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQA 761
Query: 797 ILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGF 856
+ FK F+E + KP + A+ LA EL +S+ ++LE++L +GN+MN G R + GF
Sbjct: 762 LFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGG-AYGF 820
Query: 857 KINFLCKIRDTKSA-DQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSN 915
++ L KI DTKS+ D+ +LLH++ I E+ + DIL P EL+H+ A+KV N
Sbjct: 821 RVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKV-------N 873
Query: 916 LASMEQQIVHLERDIKKFPQAENQH-------DKFVEKMTSFTKTAREQYEKLSTMHNNM 968
LA +E+++ +L R ++ E Q DKFV M+ F + + +L N
Sbjct: 874 LAELEKEVGNLRRGLRAVEVLEYQRRQVREPSDKFVPVMSDFITVSSFSFSELEDQLNEA 933
Query: 969 MKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRE-NNKRREMEEKTRRAKLAKE 1027
+ +F + +EFFG + F F EA ++ RR EE+ RRA++
Sbjct: 934 RDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAM 993
Query: 1028 KAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF 1069
EQ + ER +++++++ +E G D+L+ AL+SG F
Sbjct: 994 LKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVF 1035
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 315 bits (807), Expect = 1e-85
Identities = 259/965 (26%), Positives = 447/965 (46%), Gaps = 110/965 (11%)
Query: 186 LRVSLTSNPVSWVNNFGHE-GLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNK 244
LR L + W+ F + GL LLL+ L +L + D Q + C++A MN++
Sbjct: 53 LRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSR 112
Query: 245 FGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEEN---ILDKLLGAITTA 301
G++ IL ++ + L++A+D + ++ ++L+A+CI E LD L T
Sbjct: 113 QGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVC 172
Query: 302 AERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTM 361
+++ RFS ++ L + + V + INA++ P +L R LRNEF+ L +
Sbjct: 173 SQQY---RFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDV 229
Query: 362 LPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAA 421
L L++ E+ +L IQL+ F+E K +D EL + +M EV+ L++ + +
Sbjct: 230 LARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPV 287
Query: 422 ENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLI 481
LS+LQ L + ++ +E V++ VL S + L ++
Sbjct: 288 SAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---------ECTLEEVV 338
Query: 482 DSCVN-----------------KAKVEESEQKAAEFSKKFDEEFTARQE--AQAELQKRD 522
+ ++ +A +++S++ ++ + + Q+ A A + D
Sbjct: 339 ERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVD 398
Query: 523 EKIKELEAEIQQLRTQAQVLS-------------SSSGIPGPPAAPPLPGVG-------- 561
E ++ Q R Q S SS+ P PP PPLP VG
Sbjct: 399 HAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAP 458
Query: 562 PPPP--------PPAPPLPGGAP-----LPPPPPPLPGMMGIPPPPPPPLL---FGGPPP 605
PPPP PPAPPLP P LPPPPPPLPG+ G PPPPPP L +G PPP
Sbjct: 459 PPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGL-GCPPPPPPLLPGMGWGPPPP 517
Query: 606 PPPLGGV---PPPPG-----ISLNLPYGM------KQKKMYKPEVSMKRINWSKIEPTEL 651
PPPL PP G I + +G+ +++ P + MK++NW K+
Sbjct: 518 PPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVA 577
Query: 652 SE-NCFWLRVKEDKFE--NPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRI 708
E N W + E PD F+ + F+ K + + +K+ KE+
Sbjct: 578 REHNSMWASLSSPDAEAVEPD-FSSIERLFSFPAAKPKEPTMVAPR----ARKEPKEITF 632
Query: 709 LDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELK 768
LD K + NL+IFL ++ E++ +I + +++ L+K LPE+ + L
Sbjct: 633 LDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFT 692
Query: 769 NEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSE 828
E L + F +++ ++ Q R+ +L ++ ++P V ACE L S
Sbjct: 693 EERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSR 752
Query: 829 SFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKY 888
+L+L +GN++N GS + GFKI+ L K+ +TKS + TLLH + + E+ +
Sbjct: 753 QLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSH 812
Query: 889 RDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK-KFPQAENQHDKFVEKM 947
D+L+ P +LE A+ ++ +I++S +S ++++ ER + + + Q+ + ++
Sbjct: 813 PDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQAS 872
Query: 948 TSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVR 1007
S + E +E + + L +Y D++ +S+E+ F + FR LFL A++
Sbjct: 873 ISAFRALDELFEAIE-------QKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALK 925
Query: 1008 ENNKRREMEEKTRRAK--LAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQS 1065
EN R+E K R K LA+E+A + + E K ++ K+ +E V+D LL ++
Sbjct: 926 ENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRK--GPGKQ-EEVCVIDALLADIRK 982
Query: 1066 GAAFR 1070
G R
Sbjct: 983 GFQLR 987
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 315 bits (807), Expect = 1e-85
Identities = 259/965 (26%), Positives = 447/965 (46%), Gaps = 110/965 (11%)
Query: 186 LRVSLTSNPVSWVNNFGHE-GLGLLLDELEKLLDKKQQENIDKKNQYKLIQCLKAFMNNK 244
LR L + W+ F + GL LLL+ L +L + D Q + C++A MN++
Sbjct: 53 LRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSR 112
Query: 245 FGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEEN---ILDKLLGAITTA 301
G++ IL ++ + L++A+D + ++ ++L+A+CI E LD L T
Sbjct: 113 QGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVC 172
Query: 302 AERNNRERFSPIVEGLENQEALQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTM 361
+++ RFS ++ L + + V + INA++ P +L R LRNEF+ L +
Sbjct: 173 SQQY---RFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDV 229
Query: 362 LPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAA 421
L L++ E+ +L IQL+ F+E K +D EL + +M EV+ L++ + +
Sbjct: 230 LARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGV--DMSSHQEVFASLFHKVSCSPV 287
Query: 422 ENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLI 481
LS+LQ L + ++ +E V++ VL S + L ++
Sbjct: 288 SAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---------ECTLEEVV 338
Query: 482 DSCVN-----------------KAKVEESEQKAAEFSKKFDEEFTARQE--AQAELQKRD 522
+ ++ +A +++S++ ++ + + Q+ A A + D
Sbjct: 339 ERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVD 398
Query: 523 EKIKELEAEIQQLRTQAQVLS-------------SSSGIPGPPAAPPLPGVG-------- 561
E ++ Q R Q S SS+ P PP PPLP VG
Sbjct: 399 HAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAP 458
Query: 562 PPPP--------PPAPPLPGGAP-----LPPPPPPLPGMMGIPPPPPPPLL---FGGPPP 605
PPPP PPAPPLP P LPPPPPPLPG+ G PPPPPP L +G PPP
Sbjct: 459 PPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGL-GCPPPPPPLLPGMGWGPPPP 517
Query: 606 PPPLGGV---PPPPG-----ISLNLPYGM------KQKKMYKPEVSMKRINWSKIEPTEL 651
PPPL PP G I + +G+ +++ P + MK++NW K+
Sbjct: 518 PPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVA 577
Query: 652 SE-NCFWLRVKEDKFE--NPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRI 708
E N W + E PD F+ + F+ K + + +K+ KE+
Sbjct: 578 REHNSMWASLSSPDAEAVEPD-FSSIERLFSFPAAKPKEPTMVAPR----ARKEPKEITF 632
Query: 709 LDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELK 768
LD K + NL+IFL ++ E++ +I + +++ L+K LPE+ + L
Sbjct: 633 LDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFT 692
Query: 769 NEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSE 828
E L + F +++ ++ Q R+ +L ++ ++P V ACE L S
Sbjct: 693 EERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSR 752
Query: 829 SFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKY 888
+L+L +GN++N GS + GFKI+ L K+ +TKS + TLLH + + E+ +
Sbjct: 753 QLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSH 812
Query: 889 RDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIK-KFPQAENQHDKFVEKM 947
D+L+ P +LE A+ ++ +I++S +S ++++ ER + + + Q+ + ++
Sbjct: 813 PDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQAS 872
Query: 948 TSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVR 1007
S + E +E + + L +Y D++ +S+E+ F + FR LFL A++
Sbjct: 873 ISAFRALDELFEAIE-------QKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALK 925
Query: 1008 ENNKRREMEEKTRRAK--LAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQS 1065
EN R+E K R K LA+E+A + + E K ++ K+ +E V+D LL ++
Sbjct: 926 ENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPVRK--GPGKQ-EEVCVIDALLADIRK 982
Query: 1066 GAAFR 1070
G R
Sbjct: 983 GFQLR 987
>gi|119120861 formin-like 3 isoform 2 [Homo sapiens]
Length = 976
Score = 270 bits (689), Expect = 7e-72
Identities = 257/975 (26%), Positives = 430/975 (44%), Gaps = 129/975 (13%)
Query: 105 EVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQ 164
E+ + F ++ MNL +K LR D K +++ + +KN H Q
Sbjct: 33 ELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQ-----ERFQVKNPPHTYIQKLQ 87
Query: 165 EYVH------ELRSGISDEKLLNCLESLRVSLTSNPVSWVNNF---GHEGLGLLLDELE- 214
++ + R + + + L L +SL +N + WV F ++GL +L+D L
Sbjct: 88 SFLDPSVTRKKFRRRVQESTKV--LRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSF 145
Query: 215 --------KLLDKKQQENI----DKKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLAR 262
L ++ +N K + + I CL+A MN ++G ++ ++ +A
Sbjct: 146 AQCSVMYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIAL 205
Query: 263 AIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITTAAERNNRERFSPIVEGLENQ 320
+++ K P ++++L+A+C+V G E IL E + RF ++E N+
Sbjct: 206 SLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKELH---RFEKLMEYFRNE 262
Query: 321 EA-LQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKV 379
++ + VACMQFIN +V S +++FR+HL+ EF + GL+ L + E+++L +Q
Sbjct: 263 DSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQ--- 319
Query: 380 FDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDY 439
I+A +D++ +V LL +D +N L ++
Sbjct: 320 ------------------IQAYLDNVFDVGGLL----EDAETKNVALEKVEE-------- 349
Query: 440 YIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAE 499
+EE VS + + LD++ +++ +V E E++ +
Sbjct: 350 ---------LEEHVSHLT------------EKLLDLENENMM-------RVAELEKQLLQ 381
Query: 500 FSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQ---LRTQAQVLSSSSGIPGPPAAPP 556
K+ + + ++ IKE E Q+ L + L S P
Sbjct: 382 REKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPA 441
Query: 557 LPGVGPPPPP-----PAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGG 611
G PP PAPP PLPPPP P P PPPPP L PP PPL G
Sbjct: 442 ELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAP-------PLPPPPPPLPDKCPPAPPLPG 494
Query: 612 VPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLF 671
P +++ L ++ KK K + + NW+ ++P ++S F E E+ DL
Sbjct: 495 AAPSVVLTVGLS-AIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDL- 552
Query: 672 AKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDI 731
K F T K Q A L K +K ++ +L+ A+NL+I L E+I
Sbjct: 553 DKFEELFKT--KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEI 610
Query: 732 RNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYDDLCEPEQFGVVMSSVK 788
I + L ++ L++ LP E K+L + + ++L ++F ++ S V+
Sbjct: 611 CRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVE 670
Query: 789 MLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGS 848
L R++ + F F++++ + P + A+ A +K S+ ++LE++L +GNYMNS
Sbjct: 671 RLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSK 730
Query: 849 RNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVS 908
R A GFK+ L + DTKS D+K TLLHFIA +EKY D+ F EL VE A+ VS
Sbjct: 731 RGA-VYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS 789
Query: 909 AQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNM 968
L ++ + L R ++ + + HD V + +F T + +KL
Sbjct: 790 -------LENVLLDVKELGRGMELIRRECSIHDNSV--LRNFLSTNEGKLDKLQRDAKTA 840
Query: 969 MKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKE- 1027
+ Y + YF KT FF F + EA +EN R++ EE R +LA+E
Sbjct: 841 EEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEA 900
Query: 1028 KAEQEKLERQKKKKQ 1042
K K Q+ K Q
Sbjct: 901 KKLDAKTPSQRNKWQ 915
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 264 bits (675), Expect = 3e-70
Identities = 240/967 (24%), Positives = 422/967 (43%), Gaps = 135/967 (13%)
Query: 172 SGISDEKLLNCLESLRVSLTSNPVSWVNNFGHEGLGLLLDELEKLLDKKQQENIDKKNQY 231
+G S+ + LE L+ P S V H + L K L + + K + +
Sbjct: 170 NGASNSEKNKPLEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVS-QKDDVH 228
Query: 232 KLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENIL 291
I CL+A MN + G ++ + +A +++ K P ++++L+A+C+V +
Sbjct: 229 VCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGH-- 286
Query: 292 DKLLGAITTAAER-NNRERFSPIVEGLENQEA-LQLQVACMQFINALVTSPYELDFRIHL 349
D +L A E + RF ++E N+++ + VACMQFIN +V S ++FR+ L
Sbjct: 287 DIILAAFDNFKEVCGEQHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVENMNFRVFL 346
Query: 350 RNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKED--DLTELSHRLNDIRAEMDDMNE 407
+ EF GL L L+ E+D+L +Q++ + +N D L E + N + M+++ E
Sbjct: 347 QYEFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQE 406
Query: 408 VYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDF 467
LL L+D AEN ++ + +E+ +SQ
Sbjct: 407 QVALLTERLRD--AENESMAKIAE-----------------LEKQLSQA----------- 436
Query: 468 KYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKE 527
R+ L+ + SE A S++ E A A + K++E
Sbjct: 437 --RKELET------------LRERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEE 482
Query: 528 LEAE--IQQLRTQAQVLSSS--------------------SGIPGP---PAAPPLPGVGP 562
LE + I+ LR +S +G P P PAA P PG P
Sbjct: 483 LEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAP 542
Query: 563 PPPPP-----------------APPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPP 605
PPPPP APPLPG +P PPP PPLPG + PPPPPPP P
Sbjct: 543 PPPPPLPGLPSPQEAPPSAPPQAPPLPG-SPEPPPAPPLPGDLPPPPPPPPPPPGTDGPV 601
Query: 606 PPPLGGVPPPPG--------ISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFW 657
PPP PPPPG L G+K KK + + M +NW ++P++++ F
Sbjct: 602 PPPPPPPPPPPGGPPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFT 661
Query: 658 LRVKEDKFENPDLFAKLALNFATQIKVQKNAEALE--EKKTGPTKKKVKELRILDPKTAQ 715
E + D+ +F Q K + +L+ K+ +K + +++ A+
Sbjct: 662 ELNDEKVLQELDM-----SDFEEQFKTKSQGPSLDLSALKSKAAQKAPSKATLIEANRAK 716
Query: 716 NLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYD 772
NL+I L + E I I + L ++ L++ LP E+ ++ + +
Sbjct: 717 NLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPME 776
Query: 773 DLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNR 832
+L E ++F + S + L R++++ F F + + P + A+ A +K S+ +
Sbjct: 777 ELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQ 836
Query: 833 LLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDIL 892
+LE+VL GNYMNS R A + GF++ L + + KS D+K TLLH++ + EKY +
Sbjct: 837 ILEIVLAFGNYMNSSKRGA-AYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLT 895
Query: 893 KFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTK 952
F +L ++ A VS + +++ S+++ + +R+ + Q D V K F +
Sbjct: 896 GFHSDLHFLDKAGSVSLDSVLADVRSLQRGLELTQREFVR------QDDCMVLK--EFLR 947
Query: 953 TAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKR 1012
+KL + +E++ EYF + KT S FF + F + +A +E +
Sbjct: 948 ANSPTMDKLLADSKTAQEAFESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQW 1007
Query: 1013 REM--------------EEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDN 1058
++ E ++ + + + + K+++Q + E D G +++
Sbjct: 1008 KKEAAAQEAGADTPGKGEPPAPKSPPKARRPQMDLISELKRRQQKEPLIYESDRDGAIED 1067
Query: 1059 LLEALQS 1065
++ +++
Sbjct: 1068 IITVIKT 1074
>gi|52485606 formin-like 2 [Homo sapiens]
Length = 1092
Score = 263 bits (672), Expect = 7e-70
Identities = 234/887 (26%), Positives = 405/887 (45%), Gaps = 104/887 (11%)
Query: 220 KQQENIDKKNQYKL-IQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKI 278
K + KK+ + I CL+A MN ++G ++ ++ +A +++ K P ++++
Sbjct: 210 KNSRLVSKKDDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLEL 269
Query: 279 LSAICIV--GEENILDKLLGAITTAAERNNRERFSPIVEGLENQEA-LQLQVACMQFINA 335
L+A+C+V G E IL E+ +RF ++E N++ + VA MQFIN
Sbjct: 270 LAAVCLVRGGHEIILSAFDNFKEVCGEK---QRFEKLMEHFRNEDNNIDFMVASMQFINI 326
Query: 336 LVTSPYELDFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKED--DLTELSH 393
+V S +++FR+HL+ EF + GL L LK E+D+L +Q++ + +N D L E +
Sbjct: 327 VVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAE 386
Query: 394 RLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSI-LQHFLLIRN-DYYIRPQYYKIIEE 451
N ++++ E L L+DT E + L+ L+ RN + + + YK +
Sbjct: 387 TKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYK---D 443
Query: 452 CVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTAR 511
+Q+ H + V + EE+ Q+ + KK E
Sbjct: 444 ANTQV----------------------HTLRKMVKEK--EEAIQRQSTLEKKIHE---LE 476
Query: 512 QEAQAELQKRDEK-----------IKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPG- 559
++ ++QK+ + + +E+ + + ++S P PP PPLP
Sbjct: 477 KQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVAGNSVGPTMGAASSGPLPPPPPPLPPS 536
Query: 560 ---------------VGPPPPPPAPPLPGGAPLPPPPPPLPGMMG--IPPPP-PPPLLFG 601
+ PPPPPP PP P P PPPPPPLPG +P PP PPL
Sbjct: 537 SDTPETVQNGPVTPPMPPPPPPPPPPPP--PPPPPPPPPLPGPAAETVPAPPLAPPL--- 591
Query: 602 GPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCF----W 657
P PPL G P + + +K KK K + M NW ++P +++ F
Sbjct: 592 --PSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDD 649
Query: 658 LRVKEDKFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNL 717
R+ ED N D F ++ F T K Q A L K +K ++ +L+ A+NL
Sbjct: 650 ERILEDL--NVDEFEEI---FKT--KAQGPAIDLSSSKQKIPQKGSNKVTLLEANRAKNL 702
Query: 718 SIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLP---EQKILNELAELKNEYDDL 774
+I L ++I I + L ++ L++ LP E K+L + ++L
Sbjct: 703 AITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENL 762
Query: 775 CEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLL 834
+ ++F + S ++ L +++ + F F E I + P + A+ A +K S+ ++L
Sbjct: 763 SDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQMLTPQLHAIIAASVSIKSSQKLKKIL 822
Query: 835 ELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKF 894
E++L +GNYMNS R A GFK+ L + DTKS D+K TLLH+I+++ +EKY + F
Sbjct: 823 EIILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYHQVSLF 881
Query: 895 PEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTA 954
EL +VE A+ VS + + ++ +++ + D+ K + H+ +++ F
Sbjct: 882 YNELHYVEKAAAVSLENVLLDVKELQRGM-----DLTKREYTMHDHNTLLKE---FILNN 933
Query: 955 REQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRRE 1014
+ +KL ++++ +YF + KT FF F + +A EN R++
Sbjct: 934 EGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKK 993
Query: 1015 MEEKTRRAKLAKE---KAEQEKLERQKKKKQLIDINKEGDETGVMDN 1058
E+ L +E + + K K K+Q ++ E V DN
Sbjct: 994 QEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAELRRRQVKDN 1040
>gi|119120874 formin-like 3 isoform 1 [Homo sapiens]
Length = 1027
Score = 255 bits (652), Expect = 1e-67
Identities = 227/831 (27%), Positives = 374/831 (45%), Gaps = 100/831 (12%)
Query: 227 KKNQYKLIQCLKAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV- 285
K + + I CL+A MN ++G ++ ++ +A +++ K P ++++L+A+C+V
Sbjct: 221 KDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR 280
Query: 286 -GEENILDKLLGAITTAAERNNRERFSPIVEGLENQEA-LQLQVACMQFINALVTSPYEL 343
G E IL E + RF ++E N+++ + VACMQFIN +V S ++
Sbjct: 281 GGHEIILAAFDNFKEVCKELH---RFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDM 337
Query: 344 DFRIHLRNEFLRSGLKTMLPDLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMD 403
+FR+HL+ EF + GL+ L + E+++L +Q I+A +D
Sbjct: 338 NFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQ---------------------IQAYLD 376
Query: 404 DMNEVYHLLYNMLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGM 463
++ +V LL +D +N L ++ +EE VS +
Sbjct: 377 NVFDVGGLL----EDAETKNVALEKVEE-----------------LEEHVSHLT------ 409
Query: 464 DPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDE 523
+ LD++ +++ +V E E++ + K+ + + ++
Sbjct: 410 ------EKLLDLENENMM-------RVAELEKQLLQREKELESIKETYENTSHQVHTLRR 456
Query: 524 KIKELEAEIQQ---LRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPP-----PAPPLPGGA 575
IKE E Q+ L + L S P G PP PAPP
Sbjct: 457 LIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVL 516
Query: 576 PLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPE 635
PLPPPP P P PPPPP L PP PPL G P +++ L ++ KK K +
Sbjct: 517 PLPPPPAP-------PLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLS-AIRIKKPIKTK 568
Query: 636 VSMKRINWSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKNAEALEEKK 695
+ NW+ ++P ++S F E E+ DL K F T K Q A L K
Sbjct: 569 FRLPVFNWTALKPNQISGTVFSELDDEKILEDLDL-DKFEELFKT--KAQGPALDLICSK 625
Query: 696 TGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHL 755
+K ++ +L+ A+NL+I L E+I I + L ++ L++ L
Sbjct: 626 NKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFL 685
Query: 756 P---EQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKP 812
P E K+L + + ++L ++F ++ S V+ L R++ + F F++++ + P
Sbjct: 686 PTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTP 745
Query: 813 SIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQ 872
+ A+ A +K S+ ++LE++L +GNYMNS R A GFK+ L + DTKS D+
Sbjct: 746 QLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGA-VYGFKLQSLDLLLDTKSTDR 804
Query: 873 KTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKK 932
K TLLHFIA +EKY D+ F EL VE A+ VS L ++ + L R ++
Sbjct: 805 KMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS-------LENVLLDVKELGRGMEL 857
Query: 933 FPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFF 992
+ + HD V + +F T + +KL + Y + YF KT FF
Sbjct: 858 IRRECSIHDNSV--LRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFF 915
Query: 993 GDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKE-KAEQEKLERQKKKKQ 1042
F + EA +EN R++ EE R +LA+E K K Q+ K Q
Sbjct: 916 PVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQ 966
Score = 30.4 bits (67), Expect = 9.6
Identities = 28/118 (23%), Positives = 51/118 (43%), Gaps = 16/118 (13%)
Query: 105 EVLDLFEKMMEDMNLNEEKKAPLRNKDFTTKREMVVQYISATAKSGGLKNSKHECTLSSQ 164
E+ + F ++ MNL +K LR D K +++ + +KN H Q
Sbjct: 33 ELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQ-----ERFQVKNPPHTYIQKLQ 87
Query: 165 EYVH------ELRSGISDEKLLNCLESLRVSLTSNPVSWVNNF---GHEGLGLLLDEL 213
++ + R + + + L L +SL +N + WV F ++GL +L+D L
Sbjct: 88 SFLDPSVTRKKFRRRVQESTKV--LRELEISLRTNHIGWVREFLNDENKGLDVLVDYL 143
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 189 bits (481), Expect = 9e-48
Identities = 147/481 (30%), Positives = 227/481 (47%), Gaps = 46/481 (9%)
Query: 543 SSSSGIPGPPAAPPLPGVGPPPPPP---APPLPGGA-----PLPPPPPPLPGMMG-IPPP 593
S S IP PP +PP PPPP P A P + P PL + +PPP
Sbjct: 744 SISDHIPPPPLSPP-----PPPPLPFHDAKPSSRSSDGSRGPAQALAKPLTQLSHPVPPP 798
Query: 594 PPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSE 653
PPPPL PPP+ PP L G+ ++ +S+KR+ W ++E SE
Sbjct: 799 PPPPL-------PPPVPCAPPM------LSRGLGHRRSETSHMSVKRLRWEQVEN---SE 842
Query: 654 NCFWLRVKED----KFENPDLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKEL-RI 708
W ++ ED K + + L L+F TQ K A+ + GP + KE+ I
Sbjct: 843 GTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQ----KPAKPVP----GPEPFRKKEVVEI 894
Query: 709 LDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELK 768
L K A N SI L ++ ++R V++ + L A + L+ P+ +
Sbjct: 895 LSHKKAYNTSILLAHLKLSPAELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAFR 954
Query: 769 NEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSE 828
L EP+QF + M SV + RL S+ F+ T +E I+ S+ + A ELK S
Sbjct: 955 EAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSR 1014
Query: 829 SFNRLLELVLLVGNYMNSGS-RNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEK 887
++LE VL +GNY+N G + ++ GFKINFL ++ TK+ D K+T LH +A +
Sbjct: 1015 KLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQH 1074
Query: 888 YRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKM 947
+ ++L F ++L V A+KV+ + L S+LA + I ++ + + + DKF M
Sbjct: 1075 FPELLGFAQDLPTVPLAAKVNQRALTSDLADLHGTISEIQDACQSI--SPSSEDKFAMVM 1132
Query: 948 TSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVR 1007
+SF +TA+ L + M+ +F DSK + E FFG F + F A+
Sbjct: 1133 SSFLETAQPALRALDGLQREAMEELGKALAFFGEDSKATTSEAFFGIFAEFMSKFERALS 1192
Query: 1008 E 1008
+
Sbjct: 1193 D 1193
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 187 bits (476), Expect = 4e-47
Identities = 154/570 (27%), Positives = 261/570 (45%), Gaps = 82/570 (14%)
Query: 526 KELEAEIQQLRTQAQVLSSSSGIPGPPA-----------------APPLPGV--GPP-PP 565
K++ A +Q + A + +P PPA APP+P V GPP PP
Sbjct: 625 KDIHAALQPMEGMAS--NQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPP 682
Query: 566 PPAPPLP------GGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGV--PPPPG 617
PP PP P G P PPPPPPLP P PP P GGPPP PP G+ PPPPG
Sbjct: 683 PPPPPPPLPPPSSAGPPPPPPPPPLPNS---PAPPNP----GGPPPAPPPPGLAPPPPPG 735
Query: 618 ISLNLPYGMKQ---KKMYKPEVSMKRINWSKIEPTELSENC---FWLRVKEDKFENPDLF 671
+ L Q K +P MK + W++I+ ++ S+N W ++E +P F
Sbjct: 736 LFFGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEF 795
Query: 672 AKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDI 731
L TQ K + +E E+K K K +++LD K +Q + I + S + +DI
Sbjct: 796 EYLFSKDTTQQKKKPLSETYEKK-----NKVKKIIKLLDGKRSQTVGILISSLHLEMKDI 850
Query: 732 RNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDD--------LCEPEQFGVV 783
+ I V++ ++ + L ++ ++ +EL +++ Y+ L +PEQF
Sbjct: 851 QQAIFNVDDSVVDLETLAALYENRAQE---DELVKIRKYYETSKEEELKLLDKPEQFLHE 907
Query: 784 MSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNY 843
++ + R I+F+ F E I ++ + +T A ++L +S +L L+L GNY
Sbjct: 908 LAQIPNFAERAQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNY 967
Query: 844 MNSGSR-NAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKY-------RDILKFP 895
MN G+R Q+ G+ + L K++D KS D L+ ++ Y + + P
Sbjct: 968 MNGGNRTRGQADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLP 1027
Query: 896 EELEHVESASKVSAQILKSNLASMEQQIVHLERDI----KKFPQAENQHDKFVEKMTSFT 951
E + AS+V + L +L +++Q+ E+ + K+ P+ Q F +K+ F
Sbjct: 1028 EPQDFF-LASQVKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQ--PFKDKLEEFF 1084
Query: 952 KTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIE--------EFFGDLNNFRTLFL 1003
+ A+++++ + N K +E YF K+ E ++ ++F+T++
Sbjct: 1085 QKAKKEHKMEESHLENAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWK 1144
Query: 1004 EAVRENNKRREMEEKTRRAKLAKEKAEQEK 1033
+ +K R + +KL EK + K
Sbjct: 1145 RESKNISKERLKMAQESVSKLTSEKKVETK 1174
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 180 bits (456), Expect = 7e-45
Identities = 161/566 (28%), Positives = 259/566 (45%), Gaps = 85/566 (15%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592
+GIP PP PLPGVG PPPPP P +P PLP PPPPPLPGM GIPP
Sbjct: 1171 AGIPPPP---PLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGM-GIPPAPAPPLP 1226
Query: 593 ------PPPPPLLFGGPP----------PPPPLGGVPPPP------GISLNLPYGMKQKK 630
PPPP L GPP P P + G PPP G+ +N G + K+
Sbjct: 1227 PPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSGLFGLGMNQDKGSR-KQ 1285
Query: 631 MYKPEVSMKRINWSKIE---PTELSENCFWLRVKE---DKFENPDLFAKLALNFATQIKV 684
+P MK + W++I+ + S + W +++E D E +LF+K T +K
Sbjct: 1286 PIEPCRPMKPLYWTRIQLHSKRDSSTSLIWEKIEEPSIDCHEFEELFSK------TAVKE 1339
Query: 685 QKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLS 744
+K + KT K + +++L K +Q + I + S + +DI++ ++ ++ ++
Sbjct: 1340 RKKPISDTISKT----KAKQVVKLLSNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVD 1395
Query: 745 EALIQNLVKHLPEQKILNEL------AELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSIL 798
+Q L ++ + L ++ ++ K L +PEQF +S + R+ IL
Sbjct: 1396 LETLQALYENRAQSDELEKIEKHGRSSKDKENAKSLDKPEQFLYELSLIPNFSERVFCIL 1455
Query: 799 FKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSR-NAQSLGFK 857
F+ TF E I +I+ + + CE LK ++L LVL GNYMN G++ Q+ GF
Sbjct: 1456 FQSTFSESICSIRRKLELLQKLCETLKNGPGVMQVLGLVLAFGNYMNGGNKTRGQADGFG 1515
Query: 858 INFLCKIRDTKSADQKTTLL-----HFIADICEEKYRDILKFP-EELEHVESASKVSAQI 911
++ L K++D KS+D +LL +++ + E+ ++ FP E + + AS++ +
Sbjct: 1516 LDILPKLKDVKSSDNSRSLLSYIVSYYLRNFDEDAGKEQCLFPLPEPQDLFQASQMKFED 1575
Query: 912 LKSNLASMEQQIVHLERDIKKFPQAENQH--DKFVEKMTSFTKTAREQYEKLSTMHNNMM 969
+ +L +++ + E + K Q ++ F E M F A+ E
Sbjct: 1576 FQKDLRKLKKDLKACEVEAGKVYQVSSKEHMQPFKENMEQFIIQAKIDQEAEENSLTETH 1635
Query: 970 KLYENLGEYFI----FDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLA 1025
K + YF K VS FF + F + F + ++ NK L
Sbjct: 1636 KCFLETTAYFFMKPKLGEKEVSPNAFFSIWHEFSSDFKDFWKKENK----------LLLQ 1685
Query: 1026 KEKAEQEKLERQKKKKQLIDINKEGD 1051
+ E E++ RQKK K L I D
Sbjct: 1686 ERVKEAEEVCRQKKGKSLYKIKPRHD 1711
Score = 90.5 bits (223), Expect = 8e-18
Identities = 55/107 (51%), Positives = 57/107 (53%), Gaps = 37/107 (34%)
Query: 546 SGIPGPPAAP--------PLPGVGPPPPPPAP--------PLPG-GAPLPPP-------- 580
+GIP PP P PLPG G PPPPP P PLPG G PLPPP
Sbjct: 918 AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPP 977
Query: 581 PPPLPGMMGIPP---------PPPPPLLFGGPPPPPPL--GGVPPPP 616
PPPLPG GIPP PPPPPL G PPPPPL G+PPPP
Sbjct: 978 PPPLPG-AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1023
Score = 89.4 bits (220), Expect = 2e-17
Identities = 53/99 (53%), Positives = 56/99 (56%), Gaps = 32/99 (32%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMM 588
+GIP PP PLPG G PPPPP P PLPG PLP PPPPPLPG +
Sbjct: 1050 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-V 1105
Query: 589 GIPP---------PPPPPLLFGGPPPPPPL--GGVPPPP 616
GIPP PPPPPL G PPPPPL G+PPPP
Sbjct: 1106 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1144
Score = 88.6 bits (218), Expect = 3e-17
Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592
+GIP PP PLPG G PPPPP P +P PLP PPPPPLPG GIPP
Sbjct: 984 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPGA 1039
Query: 593 --PPPPPLLFGGPPPPPPL--GGVPPPP 616
PPPPPL G PPPPPL G+PPPP
Sbjct: 1040 GIPPPPPLPGAGIPPPPPLPGAGIPPPP 1067
Score = 88.6 bits (218), Expect = 3e-17
Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592
+GIP PP PLPG G PPPPP P +P PLP PPPPPLPG GIPP
Sbjct: 995 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPGA 1050
Query: 593 --PPPPPLLFGGPPPPPPL--GGVPPPP 616
PPPPPL G PPPPPL G+PPPP
Sbjct: 1051 GIPPPPPLPGAGIPPPPPLPGAGIPPPP 1078
Score = 88.6 bits (218), Expect = 3e-17
Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592
+GIP PP PLPG G PPPPP P +P PLP PPPPPLPG GIPP
Sbjct: 1017 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPGA 1072
Query: 593 --PPPPPLLFGGPPPPPPL--GGVPPPP 616
PPPPPL G PPPPPL G+PPPP
Sbjct: 1073 GIPPPPPLPGAGIPPPPPLPGAGIPPPP 1100
Score = 88.6 bits (218), Expect = 3e-17
Identities = 53/99 (53%), Positives = 55/99 (55%), Gaps = 32/99 (32%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMM 588
+GIP PP PLPG G PPPPP P PLPG PLP PPPPPLPG
Sbjct: 1039 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-A 1094
Query: 589 GIPP---------PPPPPLLFGGPPPPPPL--GGVPPPP 616
GIPP PPPPPL G PPPPPL G+PPPP
Sbjct: 1095 GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1133
Score = 88.6 bits (218), Expect = 3e-17
Identities = 55/107 (51%), Positives = 59/107 (55%), Gaps = 33/107 (30%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMM 588
+GIP PP PLPGVG PPPPP P PLPG PLP PPPPPLP +
Sbjct: 1094 AGIPPPP---PLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLP-RV 1149
Query: 589 GIPP---------PPPPPLLFGGPPPPPPLGGV---PPPPGISLNLP 623
GIPP PPPPPL G PPPPPL GV PPPP + +P
Sbjct: 1150 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGVGIP 1196
Score = 88.2 bits (217), Expect = 4e-17
Identities = 51/95 (53%), Positives = 52/95 (54%), Gaps = 29/95 (30%)
Query: 550 GPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMMGIPP 592
G P PPLPG G PPPPP P PLPG PLP PPPPPLPG GIPP
Sbjct: 963 GIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPP 1021
Query: 593 ---------PPPPPLLFGGPPPPPPL--GGVPPPP 616
PPPPPL G PPPPPL G+PPPP
Sbjct: 1022 PPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1056
Score = 88.2 bits (217), Expect = 4e-17
Identities = 51/88 (57%), Positives = 53/88 (60%), Gaps = 21/88 (23%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592
+GIP PP PLPG G PPPPP P +P PLP PPPPPLPG GIPP
Sbjct: 1028 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG-AGIPPPPPLPGA 1083
Query: 593 --PPPPPLLFGGPPPPPPLGGV--PPPP 616
PPPPPL G PPPPPL GV PPPP
Sbjct: 1084 GIPPPPPLPGAGIPPPPPLPGVGIPPPP 1111
Score = 87.8 bits (216), Expect = 5e-17
Identities = 50/88 (56%), Positives = 53/88 (60%), Gaps = 21/88 (23%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAPP--LPGGAPLP----PPPPPLPGMMGIPP------- 592
+GIP PP PLPG G PPPPP P +P PLP PPPPPLPG GIPP
Sbjct: 1072 AGIPPPP---PLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPG-AGIPPPPPLPGA 1127
Query: 593 --PPPPPLLFGGPPPPPPLG--GVPPPP 616
PPPPPL G PPPPPL G+PPPP
Sbjct: 1128 GIPPPPPLPGAGIPPPPPLPRVGIPPPP 1155
Score = 87.4 bits (215), Expect = 7e-17
Identities = 48/85 (56%), Positives = 49/85 (57%), Gaps = 22/85 (25%)
Query: 551 PPAAPPLPGVGPPPPPPAP-----PLPGGAPLP----PPPPPLPGMMGIPPPP------- 594
PP PPLPG G PPPPP P PLP PLP PPPPPLPG PPPP
Sbjct: 909 PPPPPPLPGAGIPPPPPLPGAGILPLP---PLPGAGIPPPPPLPGAAIPPPPPLPGAGIP 965
Query: 595 -PPPLLFGGPPPPPPL--GGVPPPP 616
PPPL G PPPPPL G+PPPP
Sbjct: 966 LPPPLPGAGIPPPPPLPGAGIPPPP 990
Score = 86.3 bits (212), Expect = 1e-16
Identities = 52/99 (52%), Positives = 54/99 (54%), Gaps = 32/99 (32%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAP--------PLPGGA-----PLP----PPPPPLPGMM 588
+GIP PP PLPG PPPPP P PLPG PLP PPPPPLPG
Sbjct: 940 AGIPPPP---PLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPG-A 995
Query: 589 GIPP---------PPPPPLLFGGPPPPPPL--GGVPPPP 616
GIPP PPPPPL G PPPPPL G+PPPP
Sbjct: 996 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1034
Score = 82.0 bits (201), Expect = 3e-15
Identities = 54/126 (42%), Positives = 59/126 (46%), Gaps = 45/126 (35%)
Query: 539 AQVLSSSSGIPGPPAAPPLP-----------GVGPPPPPP----------------APPL 571
+ +S IP PP PLP G+ PPPPPP PPL
Sbjct: 846 SSAFKNSCNIPSPP---PLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPL 902
Query: 572 PGGAPLPPPPPPLPGMMGIPPPPP---------PPLLFGGPPPPPPLGG--VPPP---PG 617
G LPPPPPPLPG GIPPPPP PPL G PPPPPL G +PPP PG
Sbjct: 903 QGTEMLPPPPPPLPG-AGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPG 961
Query: 618 ISLNLP 623
+ LP
Sbjct: 962 AGIPLP 967
Score = 80.9 bits (198), Expect = 6e-15
Identities = 53/115 (46%), Positives = 56/115 (48%), Gaps = 43/115 (37%)
Query: 544 SSSGIPG----PPAAPPLPGVG-----------PPP-------PPPAPPLPGGAPLPPPP 581
SSS +PG PP PPLPG+ PPP PPP PPLPG PPPP
Sbjct: 866 SSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPP 925
Query: 582 ---------PPLPGMMGIPP---------PPPPPLLFGGPPPPPPL--GGVPPPP 616
PPLPG GIPP PPPPPL G P PPPL G+PPPP
Sbjct: 926 LPGAGILPLPPLPG-AGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPP 979
Score = 53.5 bits (127), Expect = 1e-06
Identities = 43/143 (30%), Positives = 48/143 (33%), Gaps = 75/143 (52%)
Query: 556 PLPGVGPPPPPPA-------------------------------------------PPL- 571
P + PPPPP+ PPL
Sbjct: 803 PTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLP 862
Query: 572 --------PGGAPLPPPPPPLPGM-------MGIP-----------PPPPPPLLFGGPPP 605
PG +PPPPPPLPGM IP PPPPPPL G PP
Sbjct: 863 CTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPP 922
Query: 606 PPPLGG-----VPPPPGISLNLP 623
PPPL G +PP PG + P
Sbjct: 923 PPPLPGAGILPLPPLPGAGIPPP 945
>gi|145309324 FH2 domain containing 1 [Homo sapiens]
Length = 1143
Score = 172 bits (437), Expect = 1e-42
Identities = 138/537 (25%), Positives = 236/537 (43%), Gaps = 38/537 (7%)
Query: 565 PPPAPPLPGGAPLPPPPPPLPGMM-------GIPPPPPPPLLFGGPPPPPPLGGVPPPPG 617
PPPAPP P PPPPPP P PPPPPPP L G PP PPP G+PP
Sbjct: 30 PPPAPPPP-----PPPPPPSPPCSCSREECPSSPPPPPPPPLPGEPPIPPPPPGLPPTTH 84
Query: 618 ISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTEL--SENCFWLRVKEDKFENPDLFAKLA 675
++ G K++ M+ W I ++ N + L +++ D
Sbjct: 85 MNGYSHLGKKKR--------MRSFFWKTIPEEQVRGKTNIWTLAARQEHHYQIDTKTIEE 136
Query: 676 LNFATQIKVQKNAEALEEKKTGPTKKKVKE-LRILDPKTAQNLSIFLGSYRMPYEDIRNV 734
L F Q K++ + + ++ +E + ILD K + N+ IFL ++ I
Sbjct: 137 L-FGQQEDTTKSSLPRRGRTLNSSFREAREEITILDAKRSMNIGIFLKQFKKSPRSIVED 195
Query: 735 ILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRL 794
I + + ++ +K LPE + + +L + L + F + V R+
Sbjct: 196 IHQGKSEHYGSETLREFLKFLPESEEVKKLKAFSGDVSKLSLADSFLYGLIQVPNYSLRI 255
Query: 795 SSILFKLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSL 854
+++ K F +++ I + A +EL E + +L LVL GN MN+G ++
Sbjct: 256 EAMVLKKEFLPSCSSLYTDITVLRTAIKELMSCEELHSILHLVLQAGNIMNAGGYAGNAV 315
Query: 855 GFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKS 914
GFK++ L K+ DTK+ LLHF+A ++K +L F E+L HV+ +++S + ++
Sbjct: 316 GFKLSSLLKLADTKANKPGMNLLHFVAQEAQKKDTILLNFSEKLHHVQKTARLSLENTEA 375
Query: 915 NLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYEN 974
L + + L+ +I++ + ++M F + A E+ +L +
Sbjct: 376 ELHLLFVRTKSLKENIQR-------DGELCQQMEDFLQFAIEKLRELECWKQELQDEAYT 428
Query: 975 LGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREME-EKTRRAKLAKEKAEQEK 1033
L ++F D KT+ ++E F +F T F +AV++N+ R E + +R K EQE+
Sbjct: 429 LIDFFCEDKKTMKLDECFQIFRDFCTKFNKAVKDNHDREAQELRQLQRLK------EQEQ 482
Query: 1034 LERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFRDRRKRIPRNPVVNHPCATRA 1090
+R +L + E V + + F R P +P P R+
Sbjct: 483 KQRSWATGELGAFGRSSSENDVELLTKKGAEGLLPFLHPRPISPSSPSYRPPNTRRS 539
Score = 34.3 bits (77), Expect = 0.66
Identities = 15/24 (62%), Positives = 15/24 (62%), Gaps = 2/24 (8%)
Query: 549 PGPPAAPPLPGVGP--PPPPPAPP 570
P PP PPLPG P PPPP PP
Sbjct: 58 PPPPPPPPLPGEPPIPPPPPGLPP 81
>gi|58331242 formin homology 2 domain containing 3 [Homo sapiens]
Length = 1439
Score = 144 bits (363), Expect = 5e-34
Identities = 123/477 (25%), Positives = 219/477 (45%), Gaps = 39/477 (8%)
Query: 575 APLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGG--VPPPPGISLNLPYGMKQKKMY 632
AP PPPPPP P +G+PPPPPPPLL PPPP P G VPPPP + G Q
Sbjct: 843 APGPPPPPP-PTFLGLPPPPPPPLLDSIPPPPVP-GNLLVPPPPVFNAPQGLGWSQVPRG 900
Query: 633 KPEVSMK----RINWSKIEPTEL----SENC---FWLRVKEDKFENPDLFAKLALNFATQ 681
+P + K R+ W+++ P + + C W +++ K + L
Sbjct: 901 QPTFTKKKKTIRLFWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRL---------EH 951
Query: 682 IKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNED 741
+ K+ E KKT K+ +E+ +LD K + ++I L + P I+ IL +E
Sbjct: 952 LFESKSKELSVSKKTAADGKR-QEIIVLDSKRSNAINIGL-TVLPPPRTIKIAILNFDEY 1009
Query: 742 MLSEALIQNLVKHLP--EQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILF 799
L++ I+ ++ +P E+K + A+L N L EQF + +SS+ L RL F
Sbjct: 1010 ALNKEGIEKILTMIPTDEEKQKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAF 1069
Query: 800 KLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKIN 859
K+ +E + ++ + ++L+ +++ +L +L +GN++N + A F+++
Sbjct: 1070 KMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKA----FELS 1125
Query: 860 FLCKIRDTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASM 919
+L K+ + K K +LLH + + E + D E+ + ++KV L+ NL M
Sbjct: 1126 YLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQM 1185
Query: 920 EQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYF 979
E++ +K + E ++M+ F K E+ L +H ++ + +
Sbjct: 1186 ERRCKASWDHLKAIAKHE-MKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSF--LL 1242
Query: 980 IFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRRE--MEEKTRRAKLAKEKAEQEKL 1034
+I E ++N F + E E RE +++K +RA + + K+
Sbjct: 1243 FMGHPPYAIREV--NINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKM 1297
>gi|118572599 formin homology 2 domain containing 1 [Homo sapiens]
Length = 1164
Score = 111 bits (277), Expect = 4e-24
Identities = 126/521 (24%), Positives = 219/521 (42%), Gaps = 75/521 (14%)
Query: 522 DEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGV-GPPPPPPAPPLPGGAPLPPP 580
D +L + Q + + + IP P +PPLP + G PPPPP PP
Sbjct: 543 DLDFSDLGEDEDQDMLNVESVEAGKDIPAP--SPPLPLLSGVPPPPPL----------PP 590
Query: 581 PPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPE----- 635
PPP+ G P PPPPPL P P VP S LP K K++ E
Sbjct: 591 PPPIKG----PFPPPPPLPLAAPLP----HSVPD----SSALPTKRKTVKLFWRELKLAG 638
Query: 636 ---VSMKRIN-----WSKIEPTELSENCFWLRVKEDKFENPDLFAKLALNFATQIKVQKN 687
VS R W+ ++P + A+L F ++ K
Sbjct: 639 GHGVSASRFGPCATLWASLDPVSVDT------------------ARLEHLFESRAK---- 676
Query: 688 AEALEEKKTGPTKKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEAL 747
E L KK G ++ + +LDPK + ++I L + P I+ +L +E +S+
Sbjct: 677 -EVLPSKKAGEGRRTM--TTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDG 732
Query: 748 IQNLVKHLP--EQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEE 805
I+ L+ +P E++ E A+L N L E F + ++S+ L RL FKL ++
Sbjct: 733 IEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDS 792
Query: 806 HINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIR 865
I + + + E+L ++ +F +L +L VGN++N +QS GF++++L K+
Sbjct: 793 MEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLN----GSQSSGFELSYLEKVS 848
Query: 866 DTKSADQKTTLLHFIADICEEKYRDILKFPEELEHVESASKVSAQILKSNLASMEQQIVH 925
+ K ++ +LLH + + + + E+ + +KV + L NL +E++
Sbjct: 849 EVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRA 908
Query: 926 LERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYFIFD--- 982
E ++ + E ++T F + L +H + + Y +
Sbjct: 909 AEESLRSLAKHE-LAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQA 967
Query: 983 SKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAK 1023
++ V I +F L F L RE +++ ++ T R +
Sbjct: 968 AREVRIMQFCHTLREF-ALEYRTCRERVLQQQQKQATYRER 1007
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 82.8 bits (203), Expect = 2e-15
Identities = 56/157 (35%), Positives = 72/157 (45%), Gaps = 8/157 (5%)
Query: 464 DPDFKYRQRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDE 523
DP Q ++ L + D K++E +Q + E + D+E + A+ K
Sbjct: 602 DPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMV 661
Query: 524 KIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPP 583
A VL+ + +P PP PPLP PPPPPP P P PLPPPPPP
Sbjct: 662 VTPGAAAV-----AAPSVLAPTLPLPPPPGFPPLPPP-PPPPPPQPGFPMPPPLPPPPPP 715
Query: 584 LPGMMGIPPPPPPPL-LFGGPPPPPPLGGVPP-PPGI 618
P PPPPL G PPPP L +PP PPG+
Sbjct: 716 PPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGL 752
Score = 49.7 bits (117), Expect = 2e-05
Identities = 37/98 (37%), Positives = 40/98 (40%), Gaps = 15/98 (15%)
Query: 549 PGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPP 608
P PP PLP + PP PPP PP P P PPP P P PP PL PP P
Sbjct: 1268 PEPPMMLPLP-LQPPLPPPRPPRP---PSPPPEPETTDASH-PSVPPEPLAEDHPPHTPG 1322
Query: 609 LGG----------VPPPPGISLNLPYGMKQKKMYKPEV 636
L G VP PG L G + P+V
Sbjct: 1323 LCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQV 1360
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/61 (47%), Positives = 29/61 (47%), Gaps = 16/61 (26%)
Query: 547 GIPGPPAAPPLPGVGPP-------PPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLL 599
G P PP PP P PP PPPP P PG PPPP LP P PP PP L
Sbjct: 702 GFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPG----VPPPPILP-----PLPPFPPGL 752
Query: 600 F 600
F
Sbjct: 753 F 753
Score = 45.1 bits (105), Expect = 4e-04
Identities = 36/87 (41%), Positives = 37/87 (42%), Gaps = 21/87 (24%)
Query: 549 PGPPAA-----PPL-PGVGP-------PPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPP 595
P PPA PPL P P P PP PLP PLPPP PP P PPP
Sbjct: 1241 PEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPP----SPPPE 1296
Query: 596 PPLLFGGPP--PPPPLGGVPPP--PGI 618
P P PP PL PP PG+
Sbjct: 1297 PETTDASHPSVPPEPLAEDHPPHTPGL 1323
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/59 (40%), Positives = 26/59 (44%), Gaps = 12/59 (20%)
Query: 548 IPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPP 606
+PG P P P P G +P PPPPLP P PPPPP PPPP
Sbjct: 1509 LPGQPQTPVFPSTHDPRTVTLDFRNAG--IPAPPPPLP-----PQPPPPP-----PPPP 1555
Score = 41.6 bits (96), Expect = 0.004
Identities = 26/69 (37%), Positives = 29/69 (42%), Gaps = 7/69 (10%)
Query: 555 PPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPP 614
P P P P PG A + P P + PPP PPL PPPPPP PP
Sbjct: 647 PSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPL----PPPPPP---PPP 699
Query: 615 PPGISLNLP 623
PG + P
Sbjct: 700 QPGFPMPPP 708
Score = 38.9 bits (89), Expect = 0.027
Identities = 34/115 (29%), Positives = 39/115 (33%), Gaps = 37/115 (32%)
Query: 536 RTQAQVLSSSSGIPGPPAAPPLPG-----------VGPPPPPPAPPLPGGA--------- 575
+ Q Q ++ + P P A P PG V PPPP P A
Sbjct: 369 KAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEF 428
Query: 576 ---PLPPPPPPLPGMM----GIPPPPPPP----------LLFGGPPPPPPLGGVP 613
P PPP PP + G PP PPPP FG P P G P
Sbjct: 429 RRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTP 483
Score = 37.7 bits (86), Expect = 0.060
Identities = 26/66 (39%), Positives = 28/66 (42%), Gaps = 11/66 (16%)
Query: 550 GPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPL 609
GP A+P L G P P P P PLP P + P P PPLL P PL
Sbjct: 1417 GPLASPVLLETGLPLPLPLP-----LPLPLALPAVLRAQARAPTPLPPLL------PAPL 1465
Query: 610 GGVPPP 615
PPP
Sbjct: 1466 ASCPPP 1471
Score = 37.0 bits (84), Expect = 0.10
Identities = 25/64 (39%), Positives = 29/64 (45%), Gaps = 2/64 (3%)
Query: 548 IPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLL-FGGPPPP 606
+P P A P + P P PPL APL PPP+ G P PP +L GP
Sbjct: 1437 LPLPLALPAVLRAQARAPTPLPPLLP-APLASCPPPMKRKPGRPRRSPPSMLSLDGPLVR 1495
Query: 607 PPLG 610
PP G
Sbjct: 1496 PPAG 1499
Score = 36.2 bits (82), Expect = 0.17
Identities = 46/174 (26%), Positives = 61/174 (35%), Gaps = 51/174 (29%)
Query: 492 ESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGP 551
ES +++ S + +EE AR+E + E + +E + E Q ++ PG
Sbjct: 1122 ESSSESSPSSSEDEEEVVAREEEEEE--EEEEMVAEESMASAGPEDFEQDGEEAALAPGA 1179
Query: 552 PAA---------------------------PPLP-GVGPPPPPPAPPL-PG----GAPLP 578
PA PPLP GV P PP PG GA L
Sbjct: 1180 PAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLL 1239
Query: 579 PPPPPLPGMMGIPP-------------PPPPPLLFG---GPPPPPPLGGVPPPP 616
P PP + PP P PP++ PP PPP PP P
Sbjct: 1240 SPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSP 1293
Score = 33.1 bits (74), Expect = 1.5
Identities = 16/28 (57%), Positives = 18/28 (64%), Gaps = 4/28 (14%)
Query: 545 SSGIPGPPAAPPLPGVGPPPP--PPAPP 570
++GIP PP PPLP PPPP PP P
Sbjct: 1533 NAGIPAPP--PPLPPQPPPPPPPPPVEP 1558
Score = 32.0 bits (71), Expect = 3.3
Identities = 28/89 (31%), Positives = 34/89 (38%), Gaps = 11/89 (12%)
Query: 534 QLRTQAQVLSSSSGIPGPPA---APPLPGV-GPPPPPPAPPLPGGAPLPPPPPPLPGMMG 589
+L+ + +SSSS P A PG GP PP P G + P P P
Sbjct: 525 ELQMEGSPISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLP------ 578
Query: 590 IPPPPPPPLLFGGPPPPPPLGGVPPPPGI 618
L G P PPP G P P G+
Sbjct: 579 -DSDEDEELDLGLGPRPPPEPGPPDPAGL 606
Score = 31.6 bits (70), Expect = 4.3
Identities = 24/67 (35%), Positives = 26/67 (38%), Gaps = 10/67 (14%)
Query: 551 PPAAPPLPG---------VGPPPPPPAPPLPGGAP-LPPPPPPLPGMMGIPPPPPPPLLF 600
PP P L G P P PPL GG+ L P +PG P P P L
Sbjct: 1317 PPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSS 1376
Query: 601 GGPPPPP 607
GG P P
Sbjct: 1377 GGLPRTP 1383
>gi|7706501 WW domain binding protein 11 [Homo sapiens]
Length = 641
Score = 82.4 bits (202), Expect = 2e-15
Identities = 63/177 (35%), Positives = 82/177 (46%), Gaps = 34/177 (19%)
Query: 489 KVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQAQVLSSSSGI 548
++ E ++ EFS+ DE+ + EA+ + QK+ ++ E ++ + Q S
Sbjct: 341 EIPEEGREVEEFSEDDDEDDSDDSEAEKQSQKQHKE--ESHSDGTSTASSQQQAPPQSVP 398
Query: 549 PGPPAAPPLPGVGPPPPPPAPPL-PGGAP--LPPPPPP-------LPGMMGI-------- 590
P APP+PG P PPPAPPL P G P LPP PPP PGM G+
Sbjct: 399 PSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLL 458
Query: 591 -----------PPPPPPPLLFGGPPP--PPPLGGVPPPPGISLNLPYGMKQKKMYKP 634
PPP PPP L GPPP PPP P PPGI P GM + + P
Sbjct: 459 PPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRP-GMMRPPLVPP 514
Score = 58.2 bits (139), Expect = 4e-08
Identities = 37/73 (50%), Positives = 39/73 (53%), Gaps = 13/73 (17%)
Query: 549 PGPPAAPPLPGVGP-PPPPPAPPLPGGAPLPPPPP--PLPGMMGIPPPPPPPLLFGGPPP 605
PGPP PG P PPP P P LP G P PPP P P GIPPP P + PP
Sbjct: 460 PGPP-----PGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMM---RPPL 511
Query: 606 PPPLGGVPPPPGI 618
PPLG P PPG+
Sbjct: 512 VPPLG--PAPPGL 522
Score = 56.6 bits (135), Expect = 1e-07
Identities = 40/76 (52%), Positives = 40/76 (52%), Gaps = 10/76 (13%)
Query: 549 PG-PPAAPPLPGVG-PPPPPPAPPLPGGAPLPPP--PPPLPGMMGIP--PP--PPPPLLF 600
PG PP PP P G PP PPP P P P PP PPP PGMM P PP P PP LF
Sbjct: 464 PGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLF 523
Query: 601 GGPPPPPPLGGVPPPP 616
PP P P GV P
Sbjct: 524 --PPAPLPNPGVLSAP 537
Score = 47.4 bits (111), Expect = 8e-05
Identities = 45/150 (30%), Positives = 63/150 (42%), Gaps = 39/150 (26%)
Query: 517 ELQKRDEKIKELEAEIQQ----LRTQAQVLSSSSGIPGPPAAP--------PLPGVGPP- 563
EL+K + + ++ A++ Q ++ V S +P P AP PLPG PP
Sbjct: 106 ELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPS 165
Query: 564 ---------PPPPA----PPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLG 610
PP A P L G P PP G PP PPP GPPPP +
Sbjct: 166 ILKKTSAYGPPTRAVSILPLLGHGVPRLPP--------GRKPPGPPP----GPPPPQVVQ 213
Query: 611 GVPPPPGISLNLPYGMKQKKM-YKPEVSMK 639
G +L+LP + + M Y PE++ +
Sbjct: 214 MYGRKVGFALDLPPRRRDEDMLYSPELAQR 243
Score = 40.4 bits (93), Expect = 0.009
Identities = 24/59 (40%), Positives = 26/59 (44%), Gaps = 3/59 (5%)
Query: 549 PGPPAAPP---LPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPP 604
PGPP P LP PP PP P PL PP P P + P P P P + PP
Sbjct: 480 PGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPPGLFPPAPLPNPGVLSAPP 538
Score = 36.2 bits (82), Expect = 0.17
Identities = 30/97 (30%), Positives = 37/97 (38%), Gaps = 7/97 (7%)
Query: 492 ESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLR---TQAQVLSSSSGI 548
E EQK A+ S+ FD A+ + D IQ + Q + +
Sbjct: 113 EYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDIPLPGAQPPSILKKTSA 172
Query: 549 PGPPAAP----PLPGVGPPPPPPAPPLPGGAPLPPPP 581
GPP PL G G P PP PG P PPPP
Sbjct: 173 YGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPP 209
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 81.3 bits (199), Expect = 5e-15
Identities = 68/194 (35%), Positives = 82/194 (42%), Gaps = 55/194 (28%)
Query: 462 GMDPDFKYR-QRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDEEFTARQEAQAELQK 520
G DP+ + LD +L +L D C + E++ K E SK +
Sbjct: 216 GWDPNTGFDLNNLDPELKNLFDMC----GISEAQLKDRETSKVIYDFI------------ 259
Query: 521 RDEKIKELEAEIQQLRTQAQVLSS--------------SSGIPGPPA----APP-----L 557
EK +EA +LR QA +SG P PPA APP
Sbjct: 260 --EKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRA 317
Query: 558 PGVGPPPPPPA------PPLPGGAPLPPPPPPLPGMMGI-PPPPPPPLLFGG------PP 604
P PPPPPP+ PP P PPPPP LP PPPPPP +L G PP
Sbjct: 318 PTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPP 377
Query: 605 PPPPLGGVPPPPGI 618
PPPP G PPPPG+
Sbjct: 378 PPPPPPGPPPPPGL 391
Score = 50.1 bits (118), Expect = 1e-05
Identities = 27/44 (61%), Positives = 28/44 (63%), Gaps = 6/44 (13%)
Query: 545 SSGIPGPPAAPP-LPGVGP--PPPPPAPPLPGGAPLPPPPPPLP 585
SS GPP PP + GVGP PPPPP PP P G PPPPP LP
Sbjct: 352 SSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPG---PPPPPGLP 392
Score = 32.7 bits (73), Expect = 1.9
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 3/30 (10%)
Query: 549 PGPPAAPPLPGVGPPPPPPAPPLPGGAPLP 578
P PP PP PG PPPPP P G +P
Sbjct: 374 PPPPPPPPPPG---PPPPPGLPSDGDHQVP 400
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 79.7 bits (195), Expect = 1e-14
Identities = 56/160 (35%), Positives = 72/160 (45%), Gaps = 36/160 (22%)
Query: 489 KVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIK------ELEAEIQQLRTQAQVL 542
++E E+ E ++ + E R E + + ++R E+++ E E I A V
Sbjct: 215 RLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVE 274
Query: 543 S--------SSSGIPG------PPAAPPLPGV-----GPPPPPPAPPLPGGA-------P 576
+ SS+ PG P P G+ PPPPPP PP P A P
Sbjct: 275 TPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPP 334
Query: 577 LPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPP 616
PPPPPPLP PPPPPPPL PPPPPP PP P
Sbjct: 335 GPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP----PPAP 370
Score = 72.8 bits (177), Expect = 2e-12
Identities = 42/93 (45%), Positives = 47/93 (50%), Gaps = 16/93 (17%)
Query: 528 LEAEIQQLRTQAQ--VLSSSSGIPGPPAAPPLPGVG------PPPPPPAPPLPG-GAPLP 578
L+A Q T +Q ++ P PP PP P PP PPP PPLP G P P
Sbjct: 291 LQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPP 350
Query: 579 PPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGG 611
PPPPPLP +PPPPPPP P PP P G
Sbjct: 351 PPPPPLPNQ--VPPPPPPP-----PAPPLPASG 376
Score = 37.7 bits (86), Expect = 0.060
Identities = 38/134 (28%), Positives = 54/134 (40%), Gaps = 22/134 (16%)
Query: 495 QKAAEFSKKFDEEFTARQEAQA--ELQK-RDEKIKELEAEIQQLRTQAQVLSSSSGIPGP 551
Q+ E ++ D E RQE + L++ R E+ ++ + E +QL + + SS+ P
Sbjct: 213 QERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPAS 272
Query: 552 PAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLG- 610
PL V P L + P P GI P PPPPPPL
Sbjct: 273 -VETPLNSVLGDSSASEPGLQAASQ----PAETPSQQGIVLGPL------APPPPPPLPP 321
Query: 611 -------GVPPPPG 617
+PPPPG
Sbjct: 322 GPAQASVALPPPPG 335
Score = 34.7 bits (78), Expect = 0.51
Identities = 18/68 (26%), Positives = 45/68 (66%), Gaps = 4/68 (5%)
Query: 1011 KRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFR 1070
+RR+++E+ R+ +L +E+ E+E++ER++ +++ ++ +E E ++ E L+ R
Sbjct: 143 QRRQLQEQQRQKELERERLERERMERERLERERLE--RERLERERLEQ--EQLERERQER 198
Query: 1071 DRRKRIPR 1078
+R++R+ R
Sbjct: 199 ERQERLER 206
Score = 31.6 bits (70), Expect = 4.3
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 1004 EAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEAL 1063
E + + RE +E+ R+ +L + QE+LERQ++ ++ +++E E + LE L
Sbjct: 184 ERLEQEQLERERQERERQERLER----QERLERQERLERQERLDRERQERQERER-LERL 238
Query: 1064 QSGAAFRDRRKRIPR 1078
+ R+R++++ R
Sbjct: 239 ERERQERERQEQLER 253
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 79.7 bits (195), Expect = 1e-14
Identities = 56/160 (35%), Positives = 72/160 (45%), Gaps = 36/160 (22%)
Query: 489 KVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIK------ELEAEIQQLRTQAQVL 542
++E E+ E ++ + E R E + + ++R E+++ E E I A V
Sbjct: 215 RLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVE 274
Query: 543 S--------SSSGIPG------PPAAPPLPGV-----GPPPPPPAPPLPGGA-------P 576
+ SS+ PG P P G+ PPPPPP PP P A P
Sbjct: 275 TPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPP 334
Query: 577 LPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPP 616
PPPPPPLP PPPPPPPL PPPPPP PP P
Sbjct: 335 GPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPP----PPAP 370
Score = 72.8 bits (177), Expect = 2e-12
Identities = 42/93 (45%), Positives = 47/93 (50%), Gaps = 16/93 (17%)
Query: 528 LEAEIQQLRTQAQ--VLSSSSGIPGPPAAPPLPGVG------PPPPPPAPPLPG-GAPLP 578
L+A Q T +Q ++ P PP PP P PP PPP PPLP G P P
Sbjct: 291 LQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPP 350
Query: 579 PPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGG 611
PPPPPLP +PPPPPPP P PP P G
Sbjct: 351 PPPPPLPNQ--VPPPPPPP-----PAPPLPASG 376
Score = 37.7 bits (86), Expect = 0.060
Identities = 38/134 (28%), Positives = 54/134 (40%), Gaps = 22/134 (16%)
Query: 495 QKAAEFSKKFDEEFTARQEAQA--ELQK-RDEKIKELEAEIQQLRTQAQVLSSSSGIPGP 551
Q+ E ++ D E RQE + L++ R E+ ++ + E +QL + + SS+ P
Sbjct: 213 QERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPAS 272
Query: 552 PAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLG- 610
PL V P L + P P GI P PPPPPPL
Sbjct: 273 -VETPLNSVLGDSSASEPGLQAASQ----PAETPSQQGIVLGPL------APPPPPPLPP 321
Query: 611 -------GVPPPPG 617
+PPPPG
Sbjct: 322 GPAQASVALPPPPG 335
Score = 34.7 bits (78), Expect = 0.51
Identities = 18/68 (26%), Positives = 45/68 (66%), Gaps = 4/68 (5%)
Query: 1011 KRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAFR 1070
+RR+++E+ R+ +L +E+ E+E++ER++ +++ ++ +E E ++ E L+ R
Sbjct: 143 QRRQLQEQQRQKELERERLERERMERERLERERLE--RERLERERLEQ--EQLERERQER 198
Query: 1071 DRRKRIPR 1078
+R++R+ R
Sbjct: 199 ERQERLER 206
Score = 31.6 bits (70), Expect = 4.3
Identities = 20/75 (26%), Positives = 42/75 (56%), Gaps = 5/75 (6%)
Query: 1004 EAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEAL 1063
E + + RE +E+ R+ +L + QE+LERQ++ ++ +++E E + LE L
Sbjct: 184 ERLEQEQLERERQERERQERLER----QERLERQERLERQERLDRERQERQERER-LERL 238
Query: 1064 QSGAAFRDRRKRIPR 1078
+ R+R++++ R
Sbjct: 239 ERERQERERQEQLER 253
>gi|4507909 Wiskott-Aldrich syndrome protein [Homo sapiens]
Length = 502
Score = 79.7 bits (195), Expect = 1e-14
Identities = 61/163 (37%), Positives = 78/163 (47%), Gaps = 17/163 (10%)
Query: 462 GMDPDFKYR-QRLDIDLTHLIDSCVNKAKVEESEQKAAEFSKKFDE--EFTARQEAQAEL 518
G DP + LD DL L ++A + E++ AE SK + E EA +
Sbjct: 251 GWDPQNGFDVNNLDPDLRSLF----SRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQE 306
Query: 519 QKRDEKIKELEAEIQ---QLRTQAQVLSSSSGIPGPPAAPPLP-GVGPPPPPP-APPLPG 573
+R E + + QL + ++ + G GP PP+P G+ PPPP P PP PG
Sbjct: 307 MRRQEPLPPPPPPSRGGNQL-PRPPIVGGNKGRSGP--LPPVPLGIAPPPPTPRGPPPPG 363
Query: 574 GAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPP 616
PPPPPP G G PPPPP GGPP PPP PPPP
Sbjct: 364 RGGPPPPPPPATGRSGPLPPPPPGA--GGPPMPPPPPPPPPPP 404
Score = 75.1 bits (183), Expect = 3e-13
Identities = 37/71 (52%), Positives = 37/71 (52%), Gaps = 2/71 (2%)
Query: 549 PGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPL--PGMMGIPPPPPPPLLFGGPPPP 606
P P PP PG G PPPPP P PLPPPPP P M PPPPPPP G P P
Sbjct: 353 PPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAP 412
Query: 607 PPLGGVPPPPG 617
PPL P G
Sbjct: 413 PPLPPALVPAG 423
Score = 52.8 bits (125), Expect = 2e-06
Identities = 30/73 (41%), Positives = 34/73 (46%), Gaps = 16/73 (21%)
Query: 545 SSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPP 604
++G GP PP GPP PPP P PPPPPP G PPP PP L+
Sbjct: 374 ATGRSGPLPPPPPGAGGPPMPPPPP--------PPPPPPSSGNGPAPPPLPPALV----- 420
Query: 605 PPPPLGGVPPPPG 617
P GG+ P G
Sbjct: 421 ---PAGGLAPGGG 430
Score = 51.6 bits (122), Expect = 4e-06
Identities = 29/55 (52%), Positives = 30/55 (54%), Gaps = 3/55 (5%)
Query: 563 PPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPG 617
P PPP PP GG LP PP + G G P PP L PPPP P G PPPPG
Sbjct: 312 PLPPPPPPSRGGNQLPRPPI-VGGNKGRSGPLPPVPLGIAPPPPTPRG--PPPPG 363
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 79.7 bits (195), Expect = 1e-14
Identities = 41/96 (42%), Positives = 46/96 (47%), Gaps = 25/96 (26%)
Query: 542 LSSSSGIPGPPAAPPLPGVG-------------PPPPPPAPPLPGGAPLPPPPPPLPGMM 588
L+ ++ +PGPP P LP PPP PP P P P PPPPPP P +
Sbjct: 1424 LAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALP 1483
Query: 589 GIPP--------PPPPPLLFGGPPPPPPLGGVPPPP 616
PP PPPPPL PPPPPP PPPP
Sbjct: 1484 SPPPLVAPTPSSPPPPPL----PPPPPPAMPSPPPP 1515
Score = 72.0 bits (175), Expect = 3e-12
Identities = 34/69 (49%), Positives = 37/69 (53%), Gaps = 1/69 (1%)
Query: 549 PGPPAAP-PLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPP 607
P PP AP P P PPPPPP P LP PL P P P +PPPPPP + PPPPP
Sbjct: 1459 PTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPP 1518
Query: 608 PLGGVPPPP 616
+ PP
Sbjct: 1519 AAAPLAAPP 1527
Score = 68.2 bits (165), Expect = 4e-11
Identities = 34/67 (50%), Positives = 36/67 (53%), Gaps = 9/67 (13%)
Query: 551 PPAAPPLPGVGP-PPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPPL 609
PP PP P P PPPPP PP P LP PPP + PPPPP P PPPPP +
Sbjct: 1458 PPTPPPAPTPQPQPPPPPPPPQPA---LPSPPPLVAPTPSSPPPPPLP-----PPPPPAM 1509
Query: 610 GGVPPPP 616
PPPP
Sbjct: 1510 PSPPPPP 1516
Score = 54.3 bits (129), Expect = 6e-07
Identities = 39/117 (33%), Positives = 44/117 (37%), Gaps = 35/117 (29%)
Query: 547 GIPGPPA--APPLPGVGPPPPPPA----------------PPLPGGAPLPPPPPPLPGMM 588
G GPP P G GPPP PPA P PG P PP LP +
Sbjct: 963 GKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTV 1022
Query: 589 GIPP------------PPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYK 633
P PPPPP PPPPPP P G++ + K KK+ K
Sbjct: 1023 NAEPLGLIQSGPHQAAPPPPP-----PPPPPPAPASEPKGGLTSPIFCSTKPKKLLK 1074
Score = 51.2 bits (121), Expect = 5e-06
Identities = 28/72 (38%), Positives = 30/72 (41%), Gaps = 16/72 (22%)
Query: 549 PGPPAAPPLPGV------------GPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPP 596
P PP PP P + PPPPP PP P P PPPPPP P + PP
Sbjct: 1471 PPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPP-PAAAPLAAPPEE 1529
Query: 597 PLLFGGPPPPPP 608
P P P P
Sbjct: 1530 P---AAPSPEDP 1538
Score = 47.4 bits (111), Expect = 8e-05
Identities = 35/91 (38%), Positives = 38/91 (41%), Gaps = 34/91 (37%)
Query: 562 PPPPPPAP----PLP-------GGAPLP---PPPPP--LPGMMGIPPPPPPPLLFGG--- 602
PPPPPP P P GG LP PPPPP LP ++ P P P G
Sbjct: 764 PPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHL 823
Query: 603 -----------PPPPPPLGGVPPPPGISLNL 622
PPPPPP PPPP + L L
Sbjct: 824 LEPATRDGAPQPPPPPP----PPPPPMPLQL 850
Score = 42.7 bits (99), Expect = 0.002
Identities = 22/58 (37%), Positives = 23/58 (39%)
Query: 541 VLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPL 598
V + S P PP PP P P PPPP PP PP P P P PL
Sbjct: 1489 VAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPL 1546
Score = 39.7 bits (91), Expect = 0.016
Identities = 30/85 (35%), Positives = 33/85 (38%), Gaps = 21/85 (24%)
Query: 543 SSSSGIPGPPAAPPLPGVGPPPPPPAPPLP----------GGAPLPPPPPPLPGMMGIPP 592
++ G P PP PPPPPP PP+P G P P P P PP
Sbjct: 827 ATRDGAPQPP---------PPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPP 877
Query: 593 PPPPPLLFGGPPPPPPLG--GVPPP 615
LL P PP G GV PP
Sbjct: 878 GAMQELLGALEPLPPAPGDTGVGPP 902
Score = 38.1 bits (87), Expect = 0.046
Identities = 29/91 (31%), Positives = 34/91 (37%), Gaps = 24/91 (26%)
Query: 543 SSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMM-------GIPPPPP 595
S S+ G P G P PPP P PPPPPP+P + G+ P P
Sbjct: 813 SPSASKVGVHLLEPATRDGAPQPPPPP--------PPPPPPMPLQLEAHLRSHGLEPAAP 864
Query: 596 PPLLFGGPPPPPP---------LGGVPPPPG 617
P L PP L +PP PG
Sbjct: 865 SPRLRPEESLDPPGAMQELLGALEPLPPAPG 895
Score = 35.4 bits (80), Expect = 0.30
Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 8/81 (9%)
Query: 519 QKRDEKIKELEAEIQQLRTQAQVLSSSSGIPGPPAAPPL--PGVGPP--PPPPAPPLPGG 574
+K + KIKE+E + ++++ + S + PPL G+ PP PP PP
Sbjct: 1261 EKIEAKIKEVEEKQPEMKS-GFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPA 1319
Query: 575 APLPPPPPPLPGMMGIPPPPP 595
L P PP P +P PPP
Sbjct: 1320 RGLQPQPPATPA---VPHPPP 1337
Score = 35.0 bits (79), Expect = 0.39
Identities = 27/85 (31%), Positives = 33/85 (38%), Gaps = 23/85 (27%)
Query: 544 SSSGIPGPPAAPPLPGVGPP------PPPPAPPLP---------GGAPLPPPPPPLPGMM 588
SS + PP +PP G+ P P AP +P GG L P
Sbjct: 166 SSLSLQDPPFSPPANGLLSPHDVLHLKPSQAPTVPSSLGFERLAGGGVLGPA-------- 217
Query: 589 GIPPPPPPPLLFGGPPPPPPLGGVP 613
G+ P PP G P PPPP +P
Sbjct: 218 GLGPAQTPPYRPGPPDPPPPPRHLP 242
Score = 32.7 bits (73), Expect = 1.9
Identities = 31/93 (33%), Positives = 35/93 (37%), Gaps = 6/93 (6%)
Query: 538 QAQVLSSSSGIPGPPAAPPLPGVGPPPP-PPAPPLPGGAPLPPPPPPLPGMMGIPPPPPP 596
QA G+ GP A G G AP GG P PP PP PG+ P
Sbjct: 441 QAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPGLATCQSYSPD 500
Query: 597 PL---LFG--GPPPPPPLGGVPPPPGISLNLPY 624
L L+G G P P P P S +L Y
Sbjct: 501 QLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSY 533
Score = 32.0 bits (71), Expect = 3.3
Identities = 19/50 (38%), Positives = 21/50 (42%), Gaps = 1/50 (2%)
Query: 550 GPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLL 599
G +APP P PPP P P + PP P M P P P LL
Sbjct: 1687 GGSSAPP-PKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLL 1735
Score = 31.2 bits (69), Expect = 5.6
Identities = 31/91 (34%), Positives = 34/91 (37%), Gaps = 17/91 (18%)
Query: 538 QAQVLSS----SSGIPGPPAAPPLPGVGPPPPPPAPPLPG---GAPLPPPPPPLPGMMGI 590
QAQ LS S G P PP+ PP PG+ L G G P P P G+
Sbjct: 465 QAQDLSKAPSYSGGPPQPPSGPPPPGLATCQSYSPDQLQGQLYGVQGEPYPGPAAHSQGL 524
Query: 591 PPPPP--------PPLL--FGGPPPPPPLGG 611
P P P L GG P LGG
Sbjct: 525 PTASPSLSYSTGHSPALSGHGGGWGPSSLGG 555
Score = 31.2 bits (69), Expect = 5.6
Identities = 22/64 (34%), Positives = 25/64 (39%), Gaps = 8/64 (12%)
Query: 555 PPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPP--LLFGGPPPPPPLGGV 612
PP+P V P GG+ PPP P P PP P P PP P +
Sbjct: 1670 PPVP-VRRSGQAKNPVSAGGSSAPPPKAPAP-----PPKPETPEKTTSEKPPEQTPETAM 1723
Query: 613 PPPP 616
P PP
Sbjct: 1724 PEPP 1727
Score = 31.2 bits (69), Expect = 5.6
Identities = 19/56 (33%), Positives = 20/56 (35%), Gaps = 6/56 (10%)
Query: 553 AAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGGPPPPPP 608
A P+ G PPP AP PPP P P PP P PP P
Sbjct: 1680 AKNPVSAGGSSAPPPK------APAPPPKPETPEKTTSEKPPEQTPETAMPEPPAP 1729
Score = 30.8 bits (68), Expect = 7.3
Identities = 34/129 (26%), Positives = 38/129 (29%), Gaps = 58/129 (44%)
Query: 544 SSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGI------------- 590
+ G+ GP G+GP PP P G PPPP LP +
Sbjct: 209 AGGGVLGPA------GLGPAQTPPYRP--GPPDPPPPPRHLPTQFNLLASSSAAAAAAEQ 260
Query: 591 ------------PPPPPP----------------PLLFGGPPPPPP---------LGGVP 613
P PPPP P PPPPPP GG
Sbjct: 261 SSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSY 320
Query: 614 PPPGISLNL 622
P G NL
Sbjct: 321 PSMGHRANL 329
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 75.9 bits (185), Expect = 2e-13
Identities = 44/105 (41%), Positives = 49/105 (46%), Gaps = 27/105 (25%)
Query: 538 QAQVLSSSSGIPGPPAAPP---LPGVGPPPPPPAPPLPGGAPLPPPPPPLP-GMMGIPPP 593
++ V+S S P PP P PG PPP PP PP P +PPPPPP+ G G PPP
Sbjct: 291 RSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP-PPMIGIPPPPPPVGFGSPGTPPP 349
Query: 594 PPPPLL-----FGGPPPPP-----------------PLGGVPPPP 616
P PP F PPPPP P GG PPPP
Sbjct: 350 PSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPP 394
Score = 75.1 bits (183), Expect = 3e-13
Identities = 43/87 (49%), Positives = 48/87 (55%), Gaps = 13/87 (14%)
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAPPL-------PGGAPLPPPPPPLPGMMGIPPPPPPPL 598
SG+ GP + V P PPPAPPL PG AP P PPPP P M+GI PPPPPP+
Sbjct: 284 SGLAGPKRSSV---VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGI-PPPPPPV 339
Query: 599 LFGGP--PPPPPLGGVPPPPGISLNLP 623
FG P PPPP PP P + P
Sbjct: 340 GFGSPGTPPPPSPPSFPPHPDFAAPPP 366
Score = 74.7 bits (182), Expect = 4e-13
Identities = 41/77 (53%), Positives = 44/77 (57%), Gaps = 12/77 (15%)
Query: 547 GIPGPPAAPPL----PGVGPPPPPPA-PPLPG-GAPLPPPPPPLPGMMGIPPPPPPPLLF 600
GIP PP PP+ PG PPP PP+ PP P AP PPPPPP +PPPP
Sbjct: 331 GIPPPP--PPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTG 388
Query: 601 GGPPPPPPLGGVPPPPG 617
G PPPPPP PPPPG
Sbjct: 389 GAPPPPPP----PPPPG 401
Score = 73.6 bits (179), Expect = 1e-12
Identities = 39/84 (46%), Positives = 41/84 (48%), Gaps = 18/84 (21%)
Query: 551 PPAAPPLPGVGPPPPPPAPPLPGGAPLPPPP--PPLPGMMGIPPPPPPPLL--------- 599
PP PP+ G+ PPPPP PG P P PP PP P PPPPPPP
Sbjct: 323 PPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPP 382
Query: 600 ----FGG---PPPPPPLGGVPPPP 616
GG PPPPPP G PPPP
Sbjct: 383 LSQPTGGAPPPPPPPPPPGPPPPP 406
Score = 73.6 bits (179), Expect = 1e-12
Identities = 37/74 (50%), Positives = 39/74 (52%), Gaps = 11/74 (14%)
Query: 549 PGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPP--PPLPGMMGIPPPPPPPLLFGGPPPP 606
P PP+ PP P PPPPP PP LPPPP P G PPPPPPP GPPPP
Sbjct: 350 PSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPP----GPPPP 405
Query: 607 PPLG-----GVPPP 615
P G +PPP
Sbjct: 406 PFTGADGQPAIPPP 419
Score = 40.4 bits (93), Expect = 0.009
Identities = 19/43 (44%), Positives = 21/43 (48%), Gaps = 6/43 (13%)
Query: 548 IPGPPAAPPLPGVGPPPPPP------APPLPGGAPLPPPPPPL 584
+P PP + P G PPPPPP PP G P PPPL
Sbjct: 378 LPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPL 420
Score = 37.7 bits (86), Expect = 0.060
Identities = 17/36 (47%), Positives = 19/36 (52%), Gaps = 3/36 (8%)
Query: 545 SSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPP 580
+ G P PP PP PG PPPPP G +PPP
Sbjct: 387 TGGAPPPPPPPPPPG---PPPPPFTGADGQPAIPPP 419
>gi|91208418 transcription elongation regulator 1 isoform 2 [Homo
sapiens]
Length = 1077
Score = 73.2 bits (178), Expect = 1e-12
Identities = 55/171 (32%), Positives = 76/171 (44%), Gaps = 13/171 (7%)
Query: 530 AEIQQLRTQAQVLSSSSGIPGPPAA----PPLPGVGPPPPPPAPPLPGGAPLPPPPPPLP 585
A+ Q LR + ++ + GPP PP + PPPPP PP G P P PP+P
Sbjct: 22 AQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPF-GRPPFDPNMPPMP 80
Query: 586 GMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQ-KKMYKPEVSMKRINWS 644
GIPPP PP L P PPP+ +PPPPG + P GM P + W
Sbjct: 81 PPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPG--MMFPPGMPPVTAPGTPALPPTEEIWV 138
Query: 645 KIEPTELSENCFWLRVKEDKFENPD-----LFAKLALNFATQIKVQKNAEA 690
+ + + + R +E + PD ++L A Q +VQ A+A
Sbjct: 139 ENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQA 189
Score = 48.9 bits (115), Expect = 3e-05
Identities = 107/555 (19%), Positives = 219/555 (39%), Gaps = 76/555 (13%)
Query: 551 PPAAP---PLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLL---FGGPP 604
PPA P P P P PP P PLP P PLPG++ PP P++
Sbjct: 341 PPAVPHSVPQPTTAIPAFPPVMVPPFRVPLPGMPIPLPGVLPGMAPPIVPMIHPQVAIAA 400
Query: 605 PPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTELSENCFWLRVKEDK 664
P L G +S Y K Y W K P EL E E+K
Sbjct: 401 SPATLAGA---TAVSEWTEYKTADGKTYYYNNRTLESTWEK--PQELKEK----EKLEEK 451
Query: 665 FENP-DLFAKLALNFATQIKVQKNAEALEEKKTGPTKKKVKELRILDPKTAQNLS----- 718
+ P ++ L T+ + K E ++E K P ++++ E + K AQ
Sbjct: 452 IKEPIKEPSEEPLPMETEEEDPKE-EPIKEIKEEPKEEEMTE----EEKAAQKAKPVATA 506
Query: 719 ---------IFLGSYRMPYED--IRNVILEVNEDMLSEALIQNLVKHLPEQKILNELAEL 767
++ G R+ + + R + + +D++ A + +++ P +K + EL +L
Sbjct: 507 PIPGTPWCVVWTGDERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKL 566
Query: 768 KNEYDDLCEPEQFGVVMSSVKMLQPRLSSI---------LFKLTFEEHINNIKPSIIAVT 818
++ + +++ MS++K Q + I K + I++ K + +
Sbjct: 567 RHPTPTMLSIQKWQFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAE 626
Query: 819 LACE--------ELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSA 870
+ E + + + LLE + + ++ + + F +L
Sbjct: 627 IKAARERAIVPLEARMKQFKDMLLERGV---SAFSTWEKELHKIVFDPRYLL----LNPK 679
Query: 871 DQKTTLLHFIADICEEKYRD----ILKFPEELEHVESASKVSAQILKSNLASMEQQIVHL 926
++K ++ EE+ R+ I++ E+ + + +K + + S A+ +
Sbjct: 680 ERKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRF 739
Query: 927 ERDIKKFPQAENQHDKFV------EKMTSFT---KTAREQYEKLSTMHNNMMKLYENLGE 977
+ I+K E ++FV EK S T K + +E LS H + + + +
Sbjct: 740 -KAIEKMKDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKD 798
Query: 978 YFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQ 1037
D + +++ + F+ ++E + +N + +E R+A++ E+E+ ++
Sbjct: 799 KVESDPRYKAVDSSSMREDLFKQ-YIEKIAKNLDSEKEKELERQARIEASLREREREVQK 857
Query: 1038 KKKKQLIDINKEGDE 1052
+ +Q +I++E ++
Sbjct: 858 ARSEQTKEIDREREQ 872
>gi|21327715 transcription elongation regulator 1 isoform 1 [Homo
sapiens]
Length = 1098
Score = 73.2 bits (178), Expect = 1e-12
Identities = 55/171 (32%), Positives = 76/171 (44%), Gaps = 13/171 (7%)
Query: 530 AEIQQLRTQAQVLSSSSGIPGPPAA----PPLPGVGPPPPPPAPPLPGGAPLPPPPPPLP 585
A+ Q LR + ++ + GPP PP + PPPPP PP G P P PP+P
Sbjct: 22 AQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPF-GRPPFDPNMPPMP 80
Query: 586 GMMGIPPPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQ-KKMYKPEVSMKRINWS 644
GIPPP PP L P PPP+ +PPPPG + P GM P + W
Sbjct: 81 PPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPG--MMFPPGMPPVTAPGTPALPPTEEIWV 138
Query: 645 KIEPTELSENCFWLRVKEDKFENPD-----LFAKLALNFATQIKVQKNAEA 690
+ + + + R +E + PD ++L A Q +VQ A+A
Sbjct: 139 ENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQAQVQAQAQA 189
Score = 42.7 bits (99), Expect = 0.002
Identities = 123/711 (17%), Positives = 268/711 (37%), Gaps = 158/711 (22%)
Query: 487 KAKVEESEQKAAEFSKKFDEEFTARQEAQAELQKRDEKIKELEAEIQ-QLRTQAQVLSSS 545
+A+ + Q A+ + + A+ +AQA+ Q + + + +A+ Q Q + QAQV + +
Sbjct: 196 QAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQA 255
Query: 546 SGIPGPPAAPPLPGVGPPPPPPAP------------------------------------ 569
G P + P P V P
Sbjct: 256 VGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPTTQDQTPSSAVSVATP 315
Query: 570 ------PLPGGAPLPPPPPPLPGMMGIPPPPP-------------PPLLFGGPPPPPPLG 610
P P P+ P P P +PP P PP++ PP PL
Sbjct: 316 TVSVSTPAPTATPVQTVPQPHP--QTLPPAVPHSVPQPTTAIPAFPPVMV--PPFRVPLP 371
Query: 611 GVP-PPPGISL----NLPY-------------GMKQK--KMYKPEVSMKR---------- 640
G+P P PG+++ + PY GM M P+V++
Sbjct: 372 GMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIAASPATLAGATA 431
Query: 641 -INWSKIEPTELSENCFWLRVKEDKFENP-DLFAKLALNFATQIKVQKNAE---ALEEKK 695
W++ + + + R E +E P +L K L + +++ +E +E ++
Sbjct: 432 VSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEPSEEPLPMETEE 491
Query: 696 TGPTKKKVKELR--------ILDPKTAQNLS--------------IFLGSYRMPYED--I 731
P ++ +KE++ + K AQ ++ G R+ + +
Sbjct: 492 EDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTGDERVFFYNPTT 551
Query: 732 RNVILEVNEDMLSEALIQNLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQ 791
R + + +D++ A + +++ P +K + EL +L++ + +++ MS++K Q
Sbjct: 552 RLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQ 611
Query: 792 PRLSSI---------LFKLTFEEHINNIKPSIIAVTLACE--------ELKKSESFNRLL 834
+ I K + I++ K + + + E + + + LL
Sbjct: 612 ELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLL 671
Query: 835 ELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRD---- 890
E + + ++ + + F +L ++K ++ EE+ R+
Sbjct: 672 ERGV---SAFSTWEKELHKIVFDPRYLL----LNPKERKQVFDQYVKTRAEEERREKKNK 724
Query: 891 ILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFV------ 944
I++ E+ + + +K + + S A+ + + I+K E ++FV
Sbjct: 725 IMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRF-KAIEKMKDREALFNEFVAAARKK 783
Query: 945 EKMTSFT---KTAREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTL 1001
EK S T K + +E LS H + + + + D + +++ + F+
Sbjct: 784 EKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLFKQ- 842
Query: 1002 FLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDE 1052
++E + +N + +E R+A++ E+E+ ++ + +Q +I++E ++
Sbjct: 843 YIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQ 893
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,158,102
Number of Sequences: 37866
Number of extensions: 3038956
Number of successful extensions: 92691
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1212
Number of HSP's successfully gapped in prelim test: 1403
Number of HSP's that attempted gapping in prelim test: 24545
Number of HSP's gapped (non-prelim): 26230
length of query: 1096
length of database: 18,247,518
effective HSP length: 113
effective length of query: 983
effective length of database: 13,968,660
effective search space: 13731192780
effective search space used: 13731192780
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.