Search of human proteins with 62988328

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
         (1429 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                  2860   0.0  
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   333   7e-91
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   316   1e-85
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   316   1e-85
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       315   2e-85
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        315   2e-85
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        315   2e-85
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        315   2e-85
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        315   2e-85
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       308   3e-83
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        307   5e-83
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        307   5e-83
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   303   8e-82
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        301   4e-81
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   292   2e-78
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   257   6e-68
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    257   6e-68
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   255   2e-67
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   255   2e-67
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  243   1e-63
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   214   5e-55
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   213   1e-54
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   211   3e-54
gi|34304381 inversin isoform a [Homo sapiens]                         207   6e-53
gi|34304379 inversin isoform b [Homo sapiens]                         207   6e-53
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   203   1e-51
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   197   5e-50
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   173   9e-43
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            171   5e-42
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          165   3e-40

>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 2860 bits (7413), Expect = 0.0
 Identities = 1429/1429 (100%), Positives = 1429/1429 (100%)

Query: 1    MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNN 60
            MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNN
Sbjct: 1    MTNPWEEKVCKMAQTSLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNN 60

Query: 61   ASGVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPASLQRGLHRQALAFHFCKAQDSDT 120
            ASGVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPASLQRGLHRQALAFHFCKAQDSDT
Sbjct: 61   ASGVSGKGAAWGVLLVGGPGSGKTALCTELLWPSSPASLQRGLHRQALAFHFCKAQDSDT 120

Query: 121  LCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGM 180
            LCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGM
Sbjct: 121  LCVGGFIRGLVAQICRSGLLQGYEDKLRDPAVQSLLQPGECERNPAEAFKRCVLLPLLGM 180

Query: 181  KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSK 240
            KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSK
Sbjct: 181  KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSK 240

Query: 241  AVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSS 300
            AVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSS
Sbjct: 241  AVTKMFTGFRKISLDDLRKAYIVKDVQQYILHRLDQEEALRQHLTKETAEMLNQLHIKSS 300

Query: 301  GCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAA 360
            GCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAA
Sbjct: 301  GCFLYLERVLDGVVENFIMLREIRDIPGTLNGLYLWLCQRLFVRKQFAKVQPILNVILAA 360

Query: 361  CRPLTITELYHAVWTKNMSLTLEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKH 420
            CRPLTITELYHAVWTKNMSLTLEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKH
Sbjct: 361  CRPLTITELYHAVWTKNMSLTLEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKH 420

Query: 421  CTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGT 480
            CTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGT
Sbjct: 421  CTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIWNGT 480

Query: 481  PVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQ 540
            PVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQ
Sbjct: 481  PVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQ 540

Query: 541  CDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGC 600
            CDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGC
Sbjct: 541  CDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGC 600

Query: 601  GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660
            GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV
Sbjct: 601  GANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660

Query: 661  LNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720
            LNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC
Sbjct: 661  LNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720

Query: 721  VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN 780
            VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN
Sbjct: 721  VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN 780

Query: 781  GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840
            GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE
Sbjct: 781  GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840

Query: 841  NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900
            NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL
Sbjct: 841  NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900

Query: 901  ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960
            ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT
Sbjct: 901  ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960

Query: 961  MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA 1020
            MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA
Sbjct: 961  MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA 1020

Query: 1021 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1080
            WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT
Sbjct: 1021 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1080

Query: 1081 AMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGS 1140
            AMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGS
Sbjct: 1081 AMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGS 1140

Query: 1141 TGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTAT 1200
            TGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTAT
Sbjct: 1141 TGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTAT 1200

Query: 1201 AQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKP 1260
            AQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKP
Sbjct: 1201 AQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKP 1260

Query: 1261 SLKSTKASKGGKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPK 1320
            SLKSTKASKGGKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPK
Sbjct: 1261 SLKSTKASKGGKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPK 1320

Query: 1321 QMPAESQCKIMIPSAQQEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVS 1380
            QMPAESQCKIMIPSAQQEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVS
Sbjct: 1321 QMPAESQCKIMIPSAQQEIGRSQQQFLIHQQSGEQKKRNGIMTNPNYHLQSNQVFLGRVS 1380

Query: 1381 VPRTMQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL 1429
            VPRTMQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL
Sbjct: 1381 VPRTMQDRGHQEVLEGYPSSETELSLKQALKLQIEGSDPSFNYKKETPL 1429


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  333 bits (854), Expect = 7e-91
 Identities = 272/919 (29%), Positives = 433/919 (47%), Gaps = 141/919 (15%)

Query: 23   FYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGKGAAWGVLLVGGPGSG 82
            F  R+WVFH++   LQ      N++VN                      GV++VG  G G
Sbjct: 341  FVGRDWVFHEIDAQLQSS----NASVNQ---------------------GVVIVGNIGFG 375

Query: 83   KTALCTELLW----------------------------------PSSPASLQRG------ 102
            KTA+ + L+                                   PS+ +S+  G      
Sbjct: 376  KTAIISRLVALSCHGTRMRQIASDSPHASPKHVDANRELPLTQPPSAHSSITSGSCPGTP 435

Query: 103  ------------LHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKL-RD 149
                        L  Q +A+H+C+A ++ T  V  F+  + A +CRS  L  Y ++L R+
Sbjct: 436  EMRRRQEEAMRRLASQVVAYHYCQADNAYTCLVPEFVHNVAALLCRSPQLTAYREQLLRE 495

Query: 150  PAVQSLLQPGECERNPAEAFKRCVLLPLLGM----KPPQQSLYLLVDSVDEGCNITEGEQ 205
            P +QS+L    C ++P  +F+R VL PL  +    K P +   +L+D ++E       E 
Sbjct: 496  PHLQSMLSLRSCVQDPMASFRRGVLEPLENLHKERKIPDEDFIILIDGLNEA------EF 549

Query: 206  TSTSLSGTVAALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLRKAYIV-K 264
                   T+ + L+     FP WL L+ + R   + +TK+   F +I LD L +   + +
Sbjct: 550  HKPDYGDTIVSFLSKMIGKFPSWLKLIVTVRTSLQEITKLLP-FHRIFLDRLEENEAIDQ 608

Query: 265  DVQQYILHRLDQEEALRQHLTKET-------AEMLNQLHIKSSGCFLYLERVLDGVVENF 317
            D+Q YILHR+     ++ +++           ++ + L   S G +LYL+   D + + +
Sbjct: 609  DLQAYILHRIHSSSEIQNNISLNGKMDNTTFGKLSSHLKTLSQGSYLYLKLTFDLIEKGY 668

Query: 318  IMLRE--IRDIPGTLNGLYLWLCQRLF-VRKQFAKVQPILNVILAACRPLTITELYHAVW 374
            ++L+    + +P +L+ +YL  C   F  +  F +V P+LNV +A+  PLT   ++ A+ 
Sbjct: 669  LVLKSSSYKVVPVSLSEVYLLQCNMKFPTQSSFDRVMPLLNVAVASLHPLTDEHIFQAIN 728

Query: 375  TKNMSLTLE--DFQRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQ-KYLCNAAE 431
              ++  TLE  DFQ++++ LS  L+     T++  H SF EWL+  +   + K+LC+   
Sbjct: 729  AGSIEGTLEWEDFQQRMENLSMFLIKRRDMTRMFVHPSFREWLIWREEGEKTKFLCDPRS 788

Query: 432  GHRMLAMSYTCQAKNLTPLEAQEFALHLINSNL------QLETAELALWMIWNGTPVRD- 484
            GH +LA  ++ Q   L   +  E   H++ +++      ++  +   L  +W        
Sbjct: 789  GHTLLAFWFSRQEGKLNRQQTIELGHHILKAHIFKGLSKKVGVSSSILQGLWISYSTEGL 848

Query: 485  -----SLSTLIPKEQEVLQLLVKAGAHVNSEDDRTS----CIVRQALEREDSIRTLLDNG 535
                 SL  L     +V +LL+  GA++N   +  +      V+  L   + +  LL+ G
Sbjct: 849  SMALASLRNLYTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFG 908

Query: 536  ASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVN 595
            A+V+    +G T L  AA +G L +V LL  + A ++  D +G   L  AA +GH +VV 
Sbjct: 909  ANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVK 968

Query: 596  CLIGCGANINHTDQDGW-------TALRSAAWGGHTEVVSALLYAGVK----VDCADADS 644
             LI C   +    Q  +        AL +AA  G+TE+VS LL    K    V+ A  +S
Sbjct: 969  FLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS 1028

Query: 645  ------RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD 698
                   TAL AAA  G  ++   LL+ GA V + +  G   L +    GH +IV+ LL 
Sbjct: 1029 FDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLT 1088

Query: 699  HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE 758
            HGA+VN  D  GRT L +A     AS+GH   V  L+ +GA +   DK+G+T L  A  +
Sbjct: 1089 HGADVNMADKQGRTPLMMA-----ASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLK 1143

Query: 759  GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 818
            GH+ VV  L++ GA  DH D NGRTPL  AA  G A VV  L+  GA ++ +D  G   L
Sbjct: 1144 GHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203

Query: 819  SIASAQGNVEVVRTLLDRG 837
              A    N  VV TLL +G
Sbjct: 1204 DRAVGCRNTSVVVTLLKKG 1222



 Score =  166 bits (421), Expect = 1e-40
 Identities = 124/392 (31%), Positives = 186/392 (47%), Gaps = 35/392 (8%)

Query: 686  YMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD 745
            Y  + ++   L+  GA +N+         +   LCV +  G+  +V+LL++ GA VD   
Sbjct: 859  YTPNIKVSRLLILGGANINYRT---EVLNNAPILCVQSHLGYTEMVALLLEFGANVDASS 915

Query: 746  KDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLF--W 803
            + G+TPL  AA  G++ +V LL +  A VDH D NG+  L+ AA  GH  VV  L+   W
Sbjct: 916  ESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDW 975

Query: 804  GAA-----VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEG 858
              A     V       +  L  A++ G  E+V  LLD  L E   ++             
Sbjct: 976  TMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLD--LPEKDEEEV------------ 1021

Query: 859  HRLICEALIEQGARTNEIDND-GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNAL 917
                      + A+ N  D+  G      A+  G  +  ++LLE  + + Q    G   L
Sbjct: 1022 ----------ERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPL 1071

Query: 918  RVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 977
                 +GH  IV+LL +HGADVN  D  GR  L + A E  L   ++ L  GA++   D 
Sbjct: 1072 FSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK 1131

Query: 978  EGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 1037
            EG TAL  +C +GH+ +V+ L+   A  + AD   R+ L  AA+ G  +VVQ L++HGA+
Sbjct: 1132 EGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAM 1191

Query: 1038 VDHTCNQGATALCIAAQEGHIDVVQVLLEHGA 1069
            ++H    G   L  A    +  VV  LL+ GA
Sbjct: 1192 IEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223



 Score =  164 bits (416), Expect = 4e-40
 Identities = 127/401 (31%), Positives = 193/401 (48%), Gaps = 17/401 (4%)

Query: 592  KVVNCLIGCGANINHTDQ--DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALR 649
            KV   LI  GANIN+  +  +    L   +  G+TE+V+ LL  G  VD +     T L 
Sbjct: 864  KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923

Query: 650  AAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL--DHGAEVNHED 707
             AA  G+  IV+ L +  A+V+  D  G+ AL+ AA  GH E+V+ L+  D       + 
Sbjct: 924  YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983

Query: 708  VDGRTALSVAALCVPASKGHASVVSLLID---------RGAEVDHCDKD-GMTPLLVAAY 757
            V  ++     AL   AS G+  +VS L+D           A+++  D   G T L  AA 
Sbjct: 984  VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043

Query: 758  EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTV 817
             G ++V  LLLE GA V   +  G  PL +    GH  +V+ LL  GA V+  D +GRT 
Sbjct: 1044 RGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1103

Query: 818  LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
            L +A+++G++  V  LL +G      D  G T L  A  +GH  +  +L++ GA T+  D
Sbjct: 1104 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHAD 1163

Query: 878  NDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
             +GR P  LA+  G  + VQ L+++ + I+   Y G   L  A    +  +V  L   GA
Sbjct: 1164 KNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223

Query: 938  DVNCKD---ADGRPTLYILALENQLTMAEYFLENGANVEAS 975
             +       A  +P + I+ L   +   + F + G   EA+
Sbjct: 1224 KIGPATWAMATSKPDIMIILLSKLMEEGDMFYKKGKVKEAA 1264



 Score =  151 bits (381), Expect = 5e-36
 Identities = 113/365 (30%), Positives = 175/365 (47%), Gaps = 24/365 (6%)

Query: 663  LLQHGAEVNKADNEGRTA--LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720
            L+  GA +N        A  L   +++G+ E+V  LL+ GA V+     G T L  AA  
Sbjct: 869  LILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGYAA-- 926

Query: 721  VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGG-------AD 773
               + G+ S+V LL  + A+VDH DK+G   L+ AA  GH++VV  L++           
Sbjct: 927  ---AAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983

Query: 774  VDHTDNNGRTPLLAAASMGHASVVNTLL---------FWGAAVDSIDSE-GRTVLSIASA 823
            V    +  +  L+AAASMG+  +V+ LL            A ++S DS  G T L+ A+ 
Sbjct: 984  VFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAG 1043

Query: 824  QGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIP 883
            +G +EV R LL++G      +  G  PL     +GH  I + L+  GA  N  D  GR P
Sbjct: 1044 RGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTP 1103

Query: 884  FILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD 943
             ++A+ EGH   V  LL   ++I     +G  AL  A L+GH  +V  L  +GA  +  D
Sbjct: 1104 LMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHAD 1163

Query: 944  ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003
             +GR  L + A      + ++ +++GA +E  D  G   L  +    +  +V  L+   A
Sbjct: 1164 KNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGA 1223

Query: 1004 DVNAA 1008
             +  A
Sbjct: 1224 KIGPA 1228



 Score =  142 bits (359), Expect = 2e-33
 Identities = 109/365 (29%), Positives = 172/365 (47%), Gaps = 19/365 (5%)

Query: 757  YEGHVDVVDLLLEGGADVDH-TDNNGRTPLLAAAS-MGHASVVNTLLFWGAAVDSIDSEG 814
            Y  ++ V  LL+ GGA++++ T+     P+L   S +G+  +V  LL +GA VD+    G
Sbjct: 859  YTPNIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG 918

Query: 815  RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE-----Q 869
             T L  A+A G + +V  L  +    +H D  G   L  AA  GH  + + LI+      
Sbjct: 919  LTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMA 978

Query: 870  GARTNEIDNDGRIP--FILASQEGHYDCVQILLENKSNIDQR-------GYD---GRNAL 917
            G +         I    I A+  G+ + V  LL+     ++         +D   G  AL
Sbjct: 979  GQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETAL 1038

Query: 918  RVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 977
              AA  G  ++  LL   GA V   +  G   L+    +    + +  L +GA+V  +D 
Sbjct: 1039 TAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADK 1098

Query: 978  EGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 1037
            +GRT L ++  +GH+  V  L+A  A +   D E  +AL  A  +GH+ VV+ L+++GA 
Sbjct: 1099 QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAA 1158

Query: 1038 VDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
             DH    G T L +AA  G  +VVQ L++HGA   H D  G   +  A    ++ ++  L
Sbjct: 1159 TDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTL 1218

Query: 1098 EKYGA 1102
             K GA
Sbjct: 1219 LKKGA 1223



 Score =  127 bits (318), Expect = 1e-28
 Identities = 79/207 (38%), Positives = 109/207 (52%), Gaps = 6/207 (2%)

Query: 536  ASVNQCDSN-GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVV 594
            A +N  DS  G T L  AA  G L+V  LL+ +GA +   +  G  PL    RQGH ++V
Sbjct: 1024 AQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIV 1083

Query: 595  NCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWG 654
            + L+  GA++N  D+ G T L  AA  GH   V  LL  G  +   D +  TAL  A   
Sbjct: 1084 DLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLK 1143

Query: 655  GHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTAL 714
            GH  +V +L+ +GA  + AD  GRT L  AA+ G  E+V+ L+DHGA + H D  G   L
Sbjct: 1144 GHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203

Query: 715  SVAALCVPASKGHASVVSLLIDRGAEV 741
              A  C      + SVV  L+ +GA++
Sbjct: 1204 DRAVGC-----RNTSVVVTLLKKGAKI 1225



 Score =  108 bits (271), Expect = 3e-23
 Identities = 70/202 (34%), Positives = 103/202 (50%), Gaps = 3/202 (1%)

Query: 505  AHVNSEDD---RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVV 561
            A +NS D     T+        + +  R LL+ GA+V Q +  G   L +    G   +V
Sbjct: 1024 AQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIV 1083

Query: 562  NLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWG 621
            +LL++ GAD+ + D  G TPL +AA +GH   V+ L+  GA+I   D++G TAL  A   
Sbjct: 1084 DLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLK 1143

Query: 622  GHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
            GH  VV +L+  G   D AD + RT L  AA+ G  ++V  L+ HGA +   D  G   L
Sbjct: 1144 GHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPL 1203

Query: 682  IAAAYMGHREIVEHLLDHGAEV 703
              A    +  +V  LL  GA++
Sbjct: 1204 DRAVGCRNTSVVVTLLKKGAKI 1225



 Score =  108 bits (270), Expect = 4e-23
 Identities = 90/319 (28%), Positives = 151/319 (47%), Gaps = 35/319 (10%)

Query: 797  VNTLLFWGAAVDSIDSE---GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHM 853
            V+ LL  G A  +  +E      +L + S  G  E+V  LL+ G + +   ++G TPL  
Sbjct: 865  VSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLGY 924

Query: 854  AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE-------NKSNI 906
            AA  G+  I   L ++ A+ + +D +G+   + A+  GH + V+ L++        +  +
Sbjct: 925  AAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGV 984

Query: 907  DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFL 966
             ++ +  + AL  AA  G+ +IV  L     D+  KD            E ++  A+   
Sbjct: 985  FKKSHAIQQALIAAASMGYTEIVSYLL----DLPEKD------------EEEVERAQ--- 1025

Query: 967  ENGANVEASDAE-GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025
                 + + D+  G TAL  +  +G +E+ ++L+   A V   +      L S   QGH 
Sbjct: 1026 -----INSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHW 1080

Query: 1026 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
            ++V LL+ HGA V+    QG T L +AA EGH+  V  LL  GA     D+ G TA+  A
Sbjct: 1081 QIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWA 1140

Query: 1086 AKNGHSQIIKLLEKYGASS 1104
               GH  +++ L   GA++
Sbjct: 1141 CLKGHLSVVRSLVDNGAAT 1159



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 62/182 (34%), Positives = 95/182 (52%), Gaps = 4/182 (2%)

Query: 495  EVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS---IRTLLDNGASVNQCDSNGRTLLAN 551
            EV +LL++ GA V ++ +R   +   +  R+     +  LL +GA VN  D  GRT L  
Sbjct: 1048 EVCRLLLEQGAAV-AQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMM 1106

Query: 552  AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
            AA  G L  V+ L+++GA + + D  G T L+ A  +GH  VV  L+  GA  +H D++G
Sbjct: 1107 AASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNG 1166

Query: 612  WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
             T L  AA+ G  EVV  L+  G  ++  D      L  A    +  +V+ LL+ GA++ 
Sbjct: 1167 RTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIG 1226

Query: 672  KA 673
             A
Sbjct: 1227 PA 1228


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  316 bits (809), Expect = 1e-85
 Identities = 274/938 (29%), Positives = 434/938 (46%), Gaps = 127/938 (13%)

Query: 16   SLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGK-------G 68
            S+     F  R+W+FH+++  L+      N       +V N G   + +  K       G
Sbjct: 370  SITTDSVFVGRDWLFHQIEENLRNTELAENRGA---VVVGNVGFGKTAIISKLVALSCHG 426

Query: 69   AAWGVLLVGGPGSG-KTALCTE------LLWPSSPASLQ--------------------- 100
            +    +    PGS  KT+  T+      LL PSS  S                       
Sbjct: 427  SRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQRPREDA 486

Query: 101  -RGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKL-RDPAVQSLLQP 158
             + L  + +A+H+C+A ++ T  V  F+  + A +CRS  L  Y D L ++P +QS+L  
Sbjct: 487  VKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSL 546

Query: 159  GECERNPAEAFKRCVLLPLLGM----KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTV 214
              C ++P  AFKR VL PL  +    K P++   +L+D ++E       E        T+
Sbjct: 547  RSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEA------EFHKPDYGDTL 600

Query: 215  AALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLR-KAYIVKDVQQYILHR 273
            ++ +      FP WL L+ + R   + +      F K+SLDD      I  D+  Y+ HR
Sbjct: 601  SSFITKIISKFPAWLKLIVTVRANFQEIISALP-FVKLSLDDFPDNKDIHSDLHAYVQHR 659

Query: 274  LDQEEALRQHLT---KETAEMLNQ----LHIKSSGCFLYLERVLDGVVENFIMLREI--R 324
            +   + +  +++   K  A ++ +    L ++S G +LYL+  LD      ++++    +
Sbjct: 660  VHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYK 719

Query: 325  DIPGTLNGLYLWLCQRLFVRKQ-FAKVQPILNVILAACRPLTITELYHAVWTKNMS--LT 381
             +P +L+ LYL  C   F+ +  F +  PILNV LA+  P+T  +++ A+   ++     
Sbjct: 720  VVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQG 779

Query: 382  LEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLL---DVKHCTQKYLCNAAEGHRMLAM 438
             EDFQ+++D LS  L+     T++  H SF EWL+   D ++    +LC    GH +LA 
Sbjct: 780  WEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTA--FLCEPRNGHALLAF 837

Query: 439  SYTCQAKNLTPLEAQEFALHLINSNL--------QLETAEL-ALWMIWNG---TPVRDSL 486
             ++ Q   L   +  E   H++ +++         + ++ L ALW+ ++    +    SL
Sbjct: 838  MFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASL 897

Query: 487  STLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGR 546
              L     +V +LL+  GA+VN    RT  +                          N  
Sbjct: 898  RNLYTPNVKVSRLLILGGANVNY---RTEVL--------------------------NNA 928

Query: 547  TLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINH 606
             +L   ++ G  +VV LL+  GA L+    +G T L  AA  GH K+V  L   G  ++H
Sbjct: 929  PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDH 988

Query: 607  TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS-------RTALRAAAWGGHEDI 659
             D+ G  AL  +A  GH +++  LL            +       + AL AAA  GH  +
Sbjct: 989  LDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSV 1048

Query: 660  VLNLL----QHGAEVNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTAL 714
            V  LL    +H  EVN  D   G TAL AAA  G  E+ E LL HGA V+  +  G    
Sbjct: 1049 VQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRG---- 1104

Query: 715  SVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADV 774
             V  L   A +GH  +V LL++RG +V+  DK G TPL+VAA EGH+  V+ LL  GA +
Sbjct: 1105 -VPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL 1163

Query: 775  DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL 834
               D  G + L  A   GH +VV  L+  GAA+D  D  GRT L +A+  G+ E V  L+
Sbjct: 1164 SSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLV 1223

Query: 835  DRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 872
            ++G    H D +G  PL  A    +  +  AL+ +GA+
Sbjct: 1224 EKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261



 Score =  164 bits (416), Expect = 4e-40
 Identities = 123/410 (30%), Positives = 197/410 (48%), Gaps = 26/410 (6%)

Query: 676  EGRTALIAAA---YMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
            EG +A +A+    Y  + ++   L+  GA VN+         +   LCV +  GH  VV+
Sbjct: 888  EGLSAALASLRNLYTPNVKVSRLLILGGANVNYRT---EVLNNAPILCVQSHLGHEEVVT 944

Query: 733  LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792
            LL++ GA +D   ++GMT L  AA  GH+ +V LL + G  VDH D  G+  L+ +A  G
Sbjct: 945  LLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRG 1004

Query: 793  HASVVNTLLF--WGAAVDSIDSEGRT-----VLSIASAQGNVEVVRTLLDRGLDENHRDD 845
            H  ++  LL   W        +  ++      L+ A++ G+  VV+ LL  G+++ H  +
Sbjct: 1005 HGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVE 1062

Query: 846  A-------GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 898
                    G T L  AA  G   +CE L+  GA  +  +  G  P   A+++GH+  V++
Sbjct: 1063 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1122

Query: 899  LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
            LLE   +++     GR  L VAA EGH   VE L S GA ++  D +G   L    L+  
Sbjct: 1123 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1182

Query: 959  LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018
              + +Y +E GA ++ +D  GRT L ++ + G  E V  L+   A +   D+     L  
Sbjct: 1183 RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDR 1242

Query: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1068
            A    +  VV  L+  GA +       A A+  +  +  I ++Q L+E G
Sbjct: 1243 AIGCRNTSVVVALLRKGAKL----GNAAWAMATSKPDILIILLQKLMEEG 1288



 Score =  163 bits (412), Expect = 1e-39
 Identities = 121/358 (33%), Positives = 174/358 (48%), Gaps = 15/358 (4%)

Query: 757  YEGHVDVVDLLLEGGADVDH-TDNNGRTPLLAAAS-MGHASVVNTLLFWGAAVDSIDSEG 814
            Y  +V V  LL+ GGA+V++ T+     P+L   S +GH  VV  LL +GA +D     G
Sbjct: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960

Query: 815  RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE------ 868
             T L  A+A G++++V  L  +G+  +H D  G   L  +A  GH  I + L+       
Sbjct: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020

Query: 869  -QGARTNEIDNDGRIPFILASQEGHYDCVQILL--ENKSNIDQRGYD---GRNALRVAAL 922
                 T    +  +     A+  GH   VQ LL  E +  ++  G D   G  AL  AA 
Sbjct: 1021 PPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAG 1080

Query: 923  EGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982
             G  ++ ELL  HGA V+  +  G P L+  A +    +    LE G +V  SD +GRT 
Sbjct: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140

Query: 983  LHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 1042
            L V+  +GH+  V+ L++  A +++ D E  SAL  A  +GH  VVQ L+E GA +D T 
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTD 1200

Query: 1043 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFG-RTAMRVAAKNGHSQIIKLLEK 1099
              G T L +AA  G  + V  L+E GA   H D  G R   R       S ++ LL K
Sbjct: 1201 KNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1258



 Score =  161 bits (408), Expect = 4e-39
 Identities = 125/398 (31%), Positives = 192/398 (48%), Gaps = 12/398 (3%)

Query: 590  HTKVVNCLIGCGANINHTDQ--DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTA 647
            + KV   LI  GAN+N+  +  +    L   +  GH EVV+ LL  G  +D    +  TA
Sbjct: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963

Query: 648  LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL--DHGAEVNH 705
            L  AA  GH  +V  L + G  V+  D +G+ AL+ +A  GH +I+++LL  +       
Sbjct: 964  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1023

Query: 706  EDVDGRTALSVAALCVPASKGHASVVSLLI--DRGAEVDHCDKD---GMTPLLVAAYEGH 760
                 ++     AL   AS GH+SVV  L+  ++  EV+    D   G T L  AA  G 
Sbjct: 1024 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1083

Query: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
            ++V +LLL  GA V  T+  G  PL  AA  GH  +V  LL  G  V+  D +GRT L +
Sbjct: 1084 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1143

Query: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
            A+ +G++  V  LL +G   +  D  G + L  A  +GHR + + L+E+GA  ++ D +G
Sbjct: 1144 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1203

Query: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
            R P  LA+  G  + V  L+E  + I+   + G   L  A    +  +V  L   GA + 
Sbjct: 1204 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1263

Query: 941  ---CKDADGRPTLYILALENQLTMAEYFLENGANVEAS 975
                  A  +P + I+ L+  +       + G   EA+
Sbjct: 1264 NAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAA 1301



 Score =  130 bits (328), Expect = 7e-30
 Identities = 98/321 (30%), Positives = 156/321 (48%), Gaps = 15/321 (4%)

Query: 797  VNTLLFWGAAVDSIDSE---GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHM 853
            V+ LL  G A  +  +E      +L + S  G+ EVV  LL+ G   +   + G T L  
Sbjct: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966

Query: 854  AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE-------NKSNI 906
            AA  GH  +   L ++G R + +D  G+   + ++  GH D +Q LL         +   
Sbjct: 967  AAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGT 1026

Query: 907  DQRGYDGRNALRVAALEGHRDIVELLFS----HGADVNCKDAD-GRPTLYILALENQLTM 961
             ++ +  + AL  AA  GH  +V+ L      H  +VN  D   G   L   A   +L +
Sbjct: 1027 LRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEV 1086

Query: 962  AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAW 1021
             E  L +GA V  ++  G   L  +  QGH ++V++L+    DVN +D + R+ L  AA 
Sbjct: 1087 CELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAAC 1146

Query: 1022 QGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTA 1081
            +GH+  V+ L+  GA +     +G +AL  A  +GH  VVQ L+E GA  +  D+ GRT 
Sbjct: 1147 EGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTP 1206

Query: 1082 MRVAAKNGHSQIIKLLEKYGA 1102
            + +AA  G ++ +  L + GA
Sbjct: 1207 LDLAAFYGDAETVLYLVEKGA 1227



 Score =  114 bits (286), Expect = 5e-25
 Identities = 72/197 (36%), Positives = 102/197 (51%), Gaps = 5/197 (2%)

Query: 545  GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604
            G T L  AA  G L+V  LL+  GA +   +  G  PL  AARQGH ++V  L+  G ++
Sbjct: 1071 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1130

Query: 605  NHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLL 664
            N +D+ G T L  AA  GH   V  LL  G  +   D +  +AL  A   GH  +V  L+
Sbjct: 1131 NLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1190

Query: 665  QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPAS 724
            + GA +++ D  GRT L  AA+ G  E V +L++ GA + H D  G   L  A  C    
Sbjct: 1191 EEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGC---- 1246

Query: 725  KGHASVVSLLIDRGAEV 741
              + SVV  L+ +GA++
Sbjct: 1247 -RNTSVVVALLRKGAKL 1262



 Score =  102 bits (254), Expect = 3e-21
 Identities = 62/175 (35%), Positives = 93/175 (53%)

Query: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
            LL +GA+V++ +  G   L  AA  G   +V LL+ RG D+ + D  G TPL +AA +GH
Sbjct: 1090 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1149

Query: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
               V  L+  GA ++  D++G +AL  A   GH  VV  L+  G  +D  D + RT L  
Sbjct: 1150 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1209

Query: 651  AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNH 705
            AA+ G  + VL L++ GA +   D+ G   L  A    +  +V  LL  GA++ +
Sbjct: 1210 AAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN 1264



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 65/183 (35%), Positives = 90/183 (49%), Gaps = 6/183 (3%)

Query: 495  EVLQLLVKAGAHVNSEDDR----TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLA 550
            EV +LL+  GA V+  + R      C  RQ       +R LL+ G  VN  D  GRT L 
Sbjct: 1085 EVCELLLGHGAAVSRTNRRGVPPLFCAARQG--HWQIVRLLLERGCDVNLSDKQGRTPLM 1142

Query: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
             AA  G L  V  L+S+GA L   D  G + L+ A  +GH  VV  L+  GA I+ TD++
Sbjct: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1202

Query: 611  GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
            G T L  AA+ G  E V  L+  G  ++  D      L  A    +  +V+ LL+ GA++
Sbjct: 1203 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262

Query: 671  NKA 673
              A
Sbjct: 1263 GNA 1265


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  316 bits (809), Expect = 1e-85
 Identities = 274/938 (29%), Positives = 434/938 (46%), Gaps = 127/938 (13%)

Query: 16   SLLQGKQFYCREWVFHKLQHCLQEKSNCCNSAVNAPSLVMNSGNNASGVSGK-------G 68
            S+     F  R+W+FH+++  L+      N       +V N G   + +  K       G
Sbjct: 378  SITTDSVFVGRDWLFHQIEENLRNTELAENRGA---VVVGNVGFGKTAIISKLVALSCHG 434

Query: 69   AAWGVLLVGGPGSG-KTALCTE------LLWPSSPASLQ--------------------- 100
            +    +    PGS  KT+  T+      LL PSS  S                       
Sbjct: 435  SRMRQIASNSPGSSPKTSDPTQDLHFTPLLSPSSSTSASSTAKTPLGSISAENQRPREDA 494

Query: 101  -RGLHRQALAFHFCKAQDSDTLCVGGFIRGLVAQICRSGLLQGYEDKL-RDPAVQSLLQP 158
             + L  + +A+H+C+A ++ T  V  F+  + A +CRS  L  Y D L ++P +QS+L  
Sbjct: 495  VKYLASKVVAYHYCQADNTYTCLVPEFVHSIAALLCRSHQLAAYRDLLIKEPQLQSMLSL 554

Query: 159  GECERNPAEAFKRCVLLPLLGM----KPPQQSLYLLVDSVDEGCNITEGEQTSTSLSGTV 214
              C ++P  AFKR VL PL  +    K P++   +L+D ++E       E        T+
Sbjct: 555  RSCVQDPVAAFKRGVLEPLTNLRNEQKIPEEEYIILIDGLNEA------EFHKPDYGDTL 608

Query: 215  AALLAGHHEFFPPWLLLLCSARKQSKAVTKMFTGFRKISLDDLR-KAYIVKDVQQYILHR 273
            ++ +      FP WL L+ + R   + +      F K+SLDD      I  D+  Y+ HR
Sbjct: 609  SSFITKIISKFPAWLKLIVTVRANFQEIISALP-FVKLSLDDFPDNKDIHSDLHAYVQHR 667

Query: 274  LDQEEALRQHLT---KETAEMLNQ----LHIKSSGCFLYLERVLDGVVENFIMLREI--R 324
            +   + +  +++   K  A ++ +    L ++S G +LYL+  LD      ++++    +
Sbjct: 668  VHSSQDILSNISLNGKADATLIGKVSSHLVLRSLGSYLYLKLTLDLFQRGHLVIKSASYK 727

Query: 325  DIPGTLNGLYLWLCQRLFVRKQ-FAKVQPILNVILAACRPLTITELYHAVWTKNMS--LT 381
             +P +L+ LYL  C   F+ +  F +  PILNV LA+  P+T  +++ A+   ++     
Sbjct: 728  VVPVSLSELYLLQCNMKFMTQSAFERALPILNVALASLHPMTDEQIFQAINAGHIQGEQG 787

Query: 382  LEDFQRKLDILSKLLVDGLGNTKILFHYSFAEWLL---DVKHCTQKYLCNAAEGHRMLAM 438
             EDFQ+++D LS  L+     T++  H SF EWL+   D ++    +LC    GH +LA 
Sbjct: 788  WEDFQQRMDALSCFLIKRRDKTRMFCHPSFREWLVWRADGENTA--FLCEPRNGHALLAF 845

Query: 439  SYTCQAKNLTPLEAQEFALHLINSNL--------QLETAEL-ALWMIWNG---TPVRDSL 486
             ++ Q   L   +  E   H++ +++         + ++ L ALW+ ++    +    SL
Sbjct: 846  MFSRQEGKLNRQQTMELGHHILKAHIFKGLSKKTGISSSHLQALWIGYSTEGLSAALASL 905

Query: 487  STLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGR 546
              L     +V +LL+  GA+VN    RT  +                          N  
Sbjct: 906  RNLYTPNVKVSRLLILGGANVNY---RTEVL--------------------------NNA 936

Query: 547  TLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINH 606
             +L   ++ G  +VV LL+  GA L+    +G T L  AA  GH K+V  L   G  ++H
Sbjct: 937  PILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDH 996

Query: 607  TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS-------RTALRAAAWGGHEDI 659
             D+ G  AL  +A  GH +++  LL            +       + AL AAA  GH  +
Sbjct: 997  LDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSV 1056

Query: 660  VLNLL----QHGAEVNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTAL 714
            V  LL    +H  EVN  D   G TAL AAA  G  E+ E LL HGA V+  +  G    
Sbjct: 1057 VQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRG---- 1112

Query: 715  SVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADV 774
             V  L   A +GH  +V LL++RG +V+  DK G TPL+VAA EGH+  V+ LL  GA +
Sbjct: 1113 -VPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAAL 1171

Query: 775  DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL 834
               D  G + L  A   GH +VV  L+  GAA+D  D  GRT L +A+  G+ E V  L+
Sbjct: 1172 SSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLV 1231

Query: 835  DRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 872
            ++G    H D +G  PL  A    +  +  AL+ +GA+
Sbjct: 1232 EKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269



 Score =  169 bits (428), Expect = 2e-41
 Identities = 182/693 (26%), Positives = 290/693 (41%), Gaps = 66/693 (9%)

Query: 676  EGRTALIAAA---YMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
            EG +A +A+    Y  + ++   L+  GA VN+         +   LCV +  GH  VV+
Sbjct: 896  EGLSAALASLRNLYTPNVKVSRLLILGGANVNYRT---EVLNNAPILCVQSHLGHEEVVT 952

Query: 733  LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792
            LL++ GA +D   ++GMT L  AA  GH+ +V LL + G  VDH D  G+  L+ +A  G
Sbjct: 953  LLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRG 1012

Query: 793  HASVVNTLLF--WGAAVDSIDSEGRT-----VLSIASAQGNVEVVRTLLDRGLDENHRDD 845
            H  ++  LL   W        +  ++      L+ A++ G+  VV+ LL  G+++ H  +
Sbjct: 1013 HGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVE 1070

Query: 846  A-------GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 898
                    G T L  AA  G   +CE L+  GA  +  +  G  P   A+++GH+  V++
Sbjct: 1071 VNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRL 1130

Query: 899  LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
            LLE   +++     GR  L VAA EGH   VE L S GA ++  D +G   L    L+  
Sbjct: 1131 LLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGH 1190

Query: 959  LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018
              + +Y +E GA ++ +D  GRT L ++ + G  E V  L+   A +   D+     L  
Sbjct: 1191 RAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDR 1250

Query: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG------ADPN 1072
            A    +  VV  L+  GA +       A A+  +  +  I ++Q L+E G          
Sbjct: 1251 AIGCRNTSVVVALLRKGAKL----GNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMK 1306

Query: 1073 HADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLT 1132
             A Q  + A+R   + G  + ++   +   S     S     T +    +  +SK   L 
Sbjct: 1307 EAAQRYQYALRKFPREGFGEDMRPFNELRVSLYLNLSRCRRKTNDFGMAEEFASKALELK 1366

Query: 1133 IKS------------NSSGSTGG-GDMQPSLRGLP-NGPTHAFSSPSESPDSTVDRQKSS 1178
             KS            NS        D+Q +++  P N       +  E     + R +  
Sbjct: 1367 PKSYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQ 1426

Query: 1179 LSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFTEQ---IQQHSL-PRSRSRQSIVS 1234
                 L +  N S     +     +   D FH+    E+    Q+ S+ P  RS+ S   
Sbjct: 1427 KQQGPLPAPLNDSENEEDTPTPGLS---DHFHSEETEEEETSPQEESVSPTPRSQPSSSV 1483

Query: 1235 PSSTTQSLG---QSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQSNS 1291
            PSS  ++L    QS   P S    + +  SL+   A  G   + S K     K ++   S
Sbjct: 1484 PSSYIRNLQEGLQSKGRPVSPQSRAGIGKSLREPVAQPGLLLQPS-KQAQIVKTSQHLGS 1542

Query: 1292 SQPKVLEYEM-TQFDRRGPIAKSGTAAPPKQMP 1323
             Q  V    M  Q   + P        PP  MP
Sbjct: 1543 GQSAVRNGSMKVQISSQNP--------PPSPMP 1567



 Score =  161 bits (408), Expect = 4e-39
 Identities = 125/398 (31%), Positives = 192/398 (48%), Gaps = 12/398 (3%)

Query: 590  HTKVVNCLIGCGANINHTDQ--DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTA 647
            + KV   LI  GAN+N+  +  +    L   +  GH EVV+ LL  G  +D    +  TA
Sbjct: 912  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971

Query: 648  LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL--DHGAEVNH 705
            L  AA  GH  +V  L + G  V+  D +G+ AL+ +A  GH +I+++LL  +       
Sbjct: 972  LCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQ 1031

Query: 706  EDVDGRTALSVAALCVPASKGHASVVSLLI--DRGAEVDHCDKD---GMTPLLVAAYEGH 760
                 ++     AL   AS GH+SVV  L+  ++  EV+    D   G T L  AA  G 
Sbjct: 1032 PGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGK 1091

Query: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
            ++V +LLL  GA V  T+  G  PL  AA  GH  +V  LL  G  V+  D +GRT L +
Sbjct: 1092 LEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMV 1151

Query: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
            A+ +G++  V  LL +G   +  D  G + L  A  +GHR + + L+E+GA  ++ D +G
Sbjct: 1152 AACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNG 1211

Query: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
            R P  LA+  G  + V  L+E  + I+   + G   L  A    +  +V  L   GA + 
Sbjct: 1212 RTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLG 1271

Query: 941  ---CKDADGRPTLYILALENQLTMAEYFLENGANVEAS 975
                  A  +P + I+ L+  +       + G   EA+
Sbjct: 1272 NAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAA 1309



 Score =  114 bits (286), Expect = 5e-25
 Identities = 72/197 (36%), Positives = 102/197 (51%), Gaps = 5/197 (2%)

Query: 545  GRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604
            G T L  AA  G L+V  LL+  GA +   +  G  PL  AARQGH ++V  L+  G ++
Sbjct: 1079 GETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDV 1138

Query: 605  NHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLL 664
            N +D+ G T L  AA  GH   V  LL  G  +   D +  +AL  A   GH  +V  L+
Sbjct: 1139 NLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1198

Query: 665  QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPAS 724
            + GA +++ D  GRT L  AA+ G  E V +L++ GA + H D  G   L  A  C    
Sbjct: 1199 EEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGC---- 1254

Query: 725  KGHASVVSLLIDRGAEV 741
              + SVV  L+ +GA++
Sbjct: 1255 -RNTSVVVALLRKGAKL 1270



 Score =  102 bits (254), Expect = 3e-21
 Identities = 62/175 (35%), Positives = 93/175 (53%)

Query: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
            LL +GA+V++ +  G   L  AA  G   +V LL+ RG D+ + D  G TPL +AA +GH
Sbjct: 1098 LLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGH 1157

Query: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
               V  L+  GA ++  D++G +AL  A   GH  VV  L+  G  +D  D + RT L  
Sbjct: 1158 LSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDL 1217

Query: 651  AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNH 705
            AA+ G  + VL L++ GA +   D+ G   L  A    +  +V  LL  GA++ +
Sbjct: 1218 AAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKLGN 1272



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 65/183 (35%), Positives = 90/183 (49%), Gaps = 6/183 (3%)

Query: 495  EVLQLLVKAGAHVNSEDDR----TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLA 550
            EV +LL+  GA V+  + R      C  RQ       +R LL+ G  VN  D  GRT L 
Sbjct: 1093 EVCELLLGHGAAVSRTNRRGVPPLFCAARQG--HWQIVRLLLERGCDVNLSDKQGRTPLM 1150

Query: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
             AA  G L  V  L+S+GA L   D  G + L+ A  +GH  VV  L+  GA I+ TD++
Sbjct: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKN 1210

Query: 611  GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
            G T L  AA+ G  E V  L+  G  ++  D      L  A    +  +V+ LL+ GA++
Sbjct: 1211 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270

Query: 671  NKA 673
              A
Sbjct: 1271 GNA 1273


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  315 bits (808), Expect = 2e-85
 Identities = 206/601 (34%), Positives = 312/601 (51%), Gaps = 14/601 (2%)

Query: 524  REDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580
            R D  RT   LL N  + +     G T L  AA+  +L+V  LL++RGA +     +G T
Sbjct: 215  RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 274

Query: 581  PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640
            PL +A+R+G+  +V  L+  GA I    +D  T L  AA  GH  +   LL  G  +   
Sbjct: 275  PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 334

Query: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
              +  + +  AA G H D V  LLQ+ AE++    +  T L  AA+ GH  + + LLD G
Sbjct: 335  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 394

Query: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
            A+ N   ++G T L +A       K H  V+ LL+  GA +D   + G+TPL VA++ GH
Sbjct: 395  AKPNSRALNGFTPLHIAC-----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 449

Query: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
            + +V  LL+ GA  + ++    TPL  AA  GH  V   LL   A V++   + +T L  
Sbjct: 450  LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 509

Query: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
            A+  G+  +V+ LL+   + N    AG TPLH+AA EGH     AL+E+ A    +   G
Sbjct: 510  AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 569

Query: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
              P  +A++ G     ++LLE  ++ +  G +G   L VA    + DIV+LL   G   +
Sbjct: 570  FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629

Query: 941  CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA 1000
                +G   L+I A +NQ+ +A   L+ G +  A   +G T LH++  +GH EMV +L++
Sbjct: 630  SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 689

Query: 1001 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
              A+ N  +    + L   A +GHV V  +LI+HG +VD T   G T L +A+  G+I +
Sbjct: 690  KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749

Query: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKP 1120
            V+ LL+H AD N   + G + +  AA+ GH+ I+ LL K      NG SP+ V +    P
Sbjct: 750  VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK------NGASPNEVSSDGTTP 803

Query: 1121 L 1121
            L
Sbjct: 804  L 804



 Score =  286 bits (732), Expect = 1e-76
 Identities = 197/644 (30%), Positives = 312/644 (48%), Gaps = 44/644 (6%)

Query: 532  LDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHT 591
            L NG  +N C+ NG   L  A+  G + +V  L+ +   LE     G+T L +AA  G  
Sbjct: 65   LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124

Query: 592  KVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
            +VV  L+  GAN+N   Q G+T L  AA   H EVV  LL  G   + A  D  T L  A
Sbjct: 125  EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184

Query: 652  AWGGHEDIVLNLLQHGAE---------VNKADNEGRTALI-------------------- 682
               GHE++V +L+ +G +         +   +++ RTA +                    
Sbjct: 185  LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 244

Query: 683  AAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD 742
             AA+  +  + + LL+ GA VN    +G T L +A     + +G+  +V LL+DRGA+++
Sbjct: 245  IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA-----SRRGNVIMVRLLLDRGAQIE 299

Query: 743  HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLF 802
               KD +TPL  AA  GHV + ++LL+ GA +     NG +P+  AA   H   V  LL 
Sbjct: 300  TKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQ 359

Query: 803  WGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLI 862
            + A +D I  +  T L +A+  G+  V + LLD+G   N R   G+TPLH+A  + H  +
Sbjct: 360  YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 419

Query: 863  CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAAL 922
             E L++ GA  + +   G  P  +AS  GH   V+ LL+  ++ +         L +AA 
Sbjct: 420  MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 479

Query: 923  EGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982
             GH ++ + L  + A VN K  D +  L+  A      M +  LEN AN   +   G T 
Sbjct: 480  AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 539

Query: 983  LHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 1042
            LH++  +GH+E V  L+   A       +  + L  AA  G V+V +LL+E  A  +   
Sbjct: 540  LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599

Query: 1043 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG- 1101
              G T L +A    ++D+V++LL  G  P+     G T + +AAK    ++ + L +YG 
Sbjct: 600  KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659

Query: 1102 ---ASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTG 1142
               A S+ G   +P+H   Q+      +++ +L +   ++G+ G
Sbjct: 660  SANAESVQGV--TPLHLAAQEG----HAEMVALLLSKQANGNLG 697



 Score =  269 bits (688), Expect = 1e-71
 Identities = 185/569 (32%), Positives = 287/569 (50%), Gaps = 11/569 (1%)

Query: 576  AHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 635
            A   T    AAR G+       +  G +IN  +Q+G   L  A+  GH ++V  LL+  +
Sbjct: 43   ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102

Query: 636  KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 695
             ++       TAL  AA  G +++V  L+ +GA VN    +G T L  AA   H E+V+ 
Sbjct: 103  ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162

Query: 696  LLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755
            LL++GA  N    DG T L+VA       +GH +VV+ LI+ G +     K  +  L +A
Sbjct: 163  LLENGANQNVATEDGFTPLAVAL-----QQGHENVVAHLINYGTK----GKVRLPALHIA 213

Query: 756  AYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR 815
            A         +LL+   + D     G TPL  AA   + +V   LL  GA+V+     G 
Sbjct: 214  ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI 273

Query: 816  TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNE 875
            T L IAS +GNV +VR LLDRG     +     TPLH AA  GH  I E L++ GA    
Sbjct: 274  TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQA 333

Query: 876  IDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH 935
               +G  P  +A+Q  H DCV++LL+  + ID    D    L VAA  GH  + ++L   
Sbjct: 334  KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393

Query: 936  GADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMV 995
            GA  N +  +G   L+I   +N + + E  L+ GA+++A    G T LHV+ + GH+ +V
Sbjct: 394  GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453

Query: 996  QVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQE 1055
            + L+   A  N ++ +  + L  AA  GH +V + L+++ A V+       T L  AA+ 
Sbjct: 454  KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513

Query: 1056 GHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQ-IIKLLEKYGASS-LNGCSPSPV 1113
            GH ++V++LLE+ A+PN A   G T + +AA+ GH + ++ LLEK  + + +     +P+
Sbjct: 514  GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573

Query: 1114 HTMEQKPLQSLSSKVQSLTIKSNSSGSTG 1142
            H   +     ++  +       N++G  G
Sbjct: 574  HVAAKYGKVRVAELLLERDAHPNAAGKNG 602



 Score =  153 bits (386), Expect = 1e-36
 Identities = 123/390 (31%), Positives = 181/390 (46%), Gaps = 11/390 (2%)

Query: 447 LTPLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
           LTPL    F  HL I  NL    A   +  +   TP+  +         EV + L++  A
Sbjct: 438 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA---GHTEVAKYLLQNKA 494

Query: 506 HVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
            VN++  DD+T       +   + ++ LL+N A+ N   + G T L  AA  G ++ V  
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 554

Query: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
           L+ + A        G TPL +AA+ G  +V   L+   A+ N   ++G T L  A    +
Sbjct: 555 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 614

Query: 624 TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683
            ++V  LL  G        +  T L  AA     ++  +LLQ+G   N    +G T L  
Sbjct: 615 LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 674

Query: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
           AA  GH E+V  LL   A  N  +  G T L +      A +GH  V  +LI  G  VD 
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV-----AQEGHVPVADVLIKHGVMVDA 729

Query: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803
             + G TPL VA++ G++ +V  LL+  ADV+     G +PL  AA  GH  +V  LL  
Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789

Query: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
           GA+ + + S+G T L+IA   G + V   L
Sbjct: 790 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 54/160 (33%), Positives = 84/160 (52%)

Query: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
            K AD   +    A    L  A   L NG ++   +  G   LH++  +GH++MV  L+  
Sbjct: 41   KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100

Query: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061
               +     +  +AL  AA  G  +VV+ L+ +GA V+    +G T L +AAQE H++VV
Sbjct: 101  EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160

Query: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
            + LLE+GA+ N A + G T + VA + GH  ++  L  YG
Sbjct: 161  KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 56/196 (28%), Positives = 99/196 (50%), Gaps = 4/196 (2%)

Query: 902  NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTM 961
            N+S   ++  D   +   AA  G+ D       +G D+N  + +G   L++ + E  + M
Sbjct: 34   NRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKM 93

Query: 962  AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAW 1021
                L     +E +  +G TALH++   G  E+V+ L+ Y A+VNA   +  + L  AA 
Sbjct: 94   VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 153

Query: 1022 QGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTA 1081
            + H++VV+ L+E+GA  +     G T L +A Q+GH +VV  L+ +G       +    A
Sbjct: 154  ENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPA 209

Query: 1082 MRVAAKNGHSQIIKLL 1097
            + +AA+N  ++   +L
Sbjct: 210  LHIAARNDDTRTAAVL 225


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  315 bits (808), Expect = 2e-85
 Identities = 206/601 (34%), Positives = 312/601 (51%), Gaps = 14/601 (2%)

Query: 524  REDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580
            R D  RT   LL N  + +     G T L  AA+  +L+V  LL++RGA +     +G T
Sbjct: 182  RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241

Query: 581  PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640
            PL +A+R+G+  +V  L+  GA I    +D  T L  AA  GH  +   LL  G  +   
Sbjct: 242  PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
              +  + +  AA G H D V  LLQ+ AE++    +  T L  AA+ GH  + + LLD G
Sbjct: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361

Query: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
            A+ N   ++G T L +A       K H  V+ LL+  GA +D   + G+TPL VA++ GH
Sbjct: 362  AKPNSRALNGFTPLHIAC-----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
            + +V  LL+ GA  + ++    TPL  AA  GH  V   LL   A V++   + +T L  
Sbjct: 417  LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476

Query: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
            A+  G+  +V+ LL+   + N    AG TPLH+AA EGH     AL+E+ A    +   G
Sbjct: 477  AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
              P  +A++ G     ++LLE  ++ +  G +G   L VA    + DIV+LL   G   +
Sbjct: 537  FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 941  CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA 1000
                +G   L+I A +NQ+ +A   L+ G +  A   +G T LH++  +GH EMV +L++
Sbjct: 597  SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 1001 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
              A+ N  +    + L   A +GHV V  +LI+HG +VD T   G T L +A+  G+I +
Sbjct: 657  KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKP 1120
            V+ LL+H AD N   + G + +  AA+ GH+ I+ LL K      NG SP+ V +    P
Sbjct: 717  VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK------NGASPNEVSSDGTTP 770

Query: 1121 L 1121
            L
Sbjct: 771  L 771



 Score =  286 bits (733), Expect = 8e-77
 Identities = 203/669 (30%), Positives = 322/669 (48%), Gaps = 49/669 (7%)

Query: 510  EDDRTSCIVRQALEREDSIRTLLD---NGASVNQCDSNGRTLLANAAYSGSLDVVNLLVS 566
            E D  +  +R A  R  ++   LD   NG  +N C+ NG   L  A+  G + +V  L+ 
Sbjct: 9    EADAATSFLRAA--RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66

Query: 567  RGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEV 626
            +   LE     G+T L +AA  G  +VV  L+  GAN+N   Q G+T L  AA   H EV
Sbjct: 67   KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 627  VSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE---------VNKADNEG 677
            V  LL  G   + A  D  T L  A   GHE++V +L+ +G +         +   +++ 
Sbjct: 127  VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186

Query: 678  RTALI--------------------AAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            RTA +                     AA+  +  + + LL+ GA VN    +G T L +A
Sbjct: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
                 + +G+  +V LL+DRGA+++   KD +TPL  AA  GHV + ++LL+ GA +   
Sbjct: 247  -----SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 778  DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
              NG +P+  AA   H   V  LL + A +D I  +  T L +A+  G+  V + LLD+G
Sbjct: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361

Query: 838  LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
               N R   G+TPLH+A  + H  + E L++ GA  + +   G  P  +AS  GH   V+
Sbjct: 362  AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421

Query: 898  ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
             LL+  ++ +         L +AA  GH ++ + L  + A VN K  D +  L+  A   
Sbjct: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
               M +  LEN AN   +   G T LH++  +GH+E V  L+   A       +  + L 
Sbjct: 482  HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541

Query: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
             AA  G V+V +LL+E  A  +     G T L +A    ++D+V++LL  G  P+     
Sbjct: 542  VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYG----ASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTI 1133
            G T + +AAK    ++ + L +YG    A S+ G   +P+H   Q+      +++ +L +
Sbjct: 602  GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEG----HAEMVALLL 655

Query: 1134 KSNSSGSTG 1142
               ++G+ G
Sbjct: 656  SKQANGNLG 664



 Score =  153 bits (386), Expect = 1e-36
 Identities = 123/390 (31%), Positives = 181/390 (46%), Gaps = 11/390 (2%)

Query: 447 LTPLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
           LTPL    F  HL I  NL    A   +  +   TP+  +         EV + L++  A
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA---GHTEVAKYLLQNKA 461

Query: 506 HVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
            VN++  DD+T       +   + ++ LL+N A+ N   + G T L  AA  G ++ V  
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
           L+ + A        G TPL +AA+ G  +V   L+   A+ N   ++G T L  A    +
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581

Query: 624 TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683
            ++V  LL  G        +  T L  AA     ++  +LLQ+G   N    +G T L  
Sbjct: 582 LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641

Query: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
           AA  GH E+V  LL   A  N  +  G T L +      A +GH  V  +LI  G  VD 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV-----AQEGHVPVADVLIKHGVMVDA 696

Query: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803
             + G TPL VA++ G++ +V  LL+  ADV+     G +PL  AA  GH  +V  LL  
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756

Query: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
           GA+ + + S+G T L+IA   G + V   L
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 54/163 (33%), Positives = 86/163 (52%)

Query: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
            V  ++AD   +    A    L  A   L NG ++   +  G   LH++  +GH++MV  L
Sbjct: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
            +     +     +  +AL  AA  G  +VV+ L+ +GA V+    +G T L +AAQE H+
Sbjct: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
            +VV+ LLE+GA+ N A + G T + VA + GH  ++  L  YG
Sbjct: 125  EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  315 bits (808), Expect = 2e-85
 Identities = 206/601 (34%), Positives = 312/601 (51%), Gaps = 14/601 (2%)

Query: 524  REDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580
            R D  RT   LL N  + +     G T L  AA+  +L+V  LL++RGA +     +G T
Sbjct: 182  RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241

Query: 581  PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640
            PL +A+R+G+  +V  L+  GA I    +D  T L  AA  GH  +   LL  G  +   
Sbjct: 242  PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
              +  + +  AA G H D V  LLQ+ AE++    +  T L  AA+ GH  + + LLD G
Sbjct: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361

Query: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
            A+ N   ++G T L +A       K H  V+ LL+  GA +D   + G+TPL VA++ GH
Sbjct: 362  AKPNSRALNGFTPLHIAC-----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
            + +V  LL+ GA  + ++    TPL  AA  GH  V   LL   A V++   + +T L  
Sbjct: 417  LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476

Query: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
            A+  G+  +V+ LL+   + N    AG TPLH+AA EGH     AL+E+ A    +   G
Sbjct: 477  AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
              P  +A++ G     ++LLE  ++ +  G +G   L VA    + DIV+LL   G   +
Sbjct: 537  FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 941  CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA 1000
                +G   L+I A +NQ+ +A   L+ G +  A   +G T LH++  +GH EMV +L++
Sbjct: 597  SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 1001 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
              A+ N  +    + L   A +GHV V  +LI+HG +VD T   G T L +A+  G+I +
Sbjct: 657  KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKP 1120
            V+ LL+H AD N   + G + +  AA+ GH+ I+ LL K      NG SP+ V +    P
Sbjct: 717  VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK------NGASPNEVSSDGTTP 770

Query: 1121 L 1121
            L
Sbjct: 771  L 771



 Score =  286 bits (733), Expect = 8e-77
 Identities = 203/669 (30%), Positives = 322/669 (48%), Gaps = 49/669 (7%)

Query: 510  EDDRTSCIVRQALEREDSIRTLLD---NGASVNQCDSNGRTLLANAAYSGSLDVVNLLVS 566
            E D  +  +R A  R  ++   LD   NG  +N C+ NG   L  A+  G + +V  L+ 
Sbjct: 9    EADAATSFLRAA--RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66

Query: 567  RGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEV 626
            +   LE     G+T L +AA  G  +VV  L+  GAN+N   Q G+T L  AA   H EV
Sbjct: 67   KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 627  VSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE---------VNKADNEG 677
            V  LL  G   + A  D  T L  A   GHE++V +L+ +G +         +   +++ 
Sbjct: 127  VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186

Query: 678  RTALI--------------------AAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            RTA +                     AA+  +  + + LL+ GA VN    +G T L +A
Sbjct: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
                 + +G+  +V LL+DRGA+++   KD +TPL  AA  GHV + ++LL+ GA +   
Sbjct: 247  -----SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 778  DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
              NG +P+  AA   H   V  LL + A +D I  +  T L +A+  G+  V + LLD+G
Sbjct: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361

Query: 838  LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
               N R   G+TPLH+A  + H  + E L++ GA  + +   G  P  +AS  GH   V+
Sbjct: 362  AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421

Query: 898  ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
             LL+  ++ +         L +AA  GH ++ + L  + A VN K  D +  L+  A   
Sbjct: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
               M +  LEN AN   +   G T LH++  +GH+E V  L+   A       +  + L 
Sbjct: 482  HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541

Query: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
             AA  G V+V +LL+E  A  +     G T L +A    ++D+V++LL  G  P+     
Sbjct: 542  VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYG----ASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTI 1133
            G T + +AAK    ++ + L +YG    A S+ G   +P+H   Q+      +++ +L +
Sbjct: 602  GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEG----HAEMVALLL 655

Query: 1134 KSNSSGSTG 1142
               ++G+ G
Sbjct: 656  SKQANGNLG 664



 Score =  153 bits (386), Expect = 1e-36
 Identities = 123/390 (31%), Positives = 181/390 (46%), Gaps = 11/390 (2%)

Query: 447 LTPLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
           LTPL    F  HL I  NL    A   +  +   TP+  +         EV + L++  A
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA---GHTEVAKYLLQNKA 461

Query: 506 HVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
            VN++  DD+T       +   + ++ LL+N A+ N   + G T L  AA  G ++ V  
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
           L+ + A        G TPL +AA+ G  +V   L+   A+ N   ++G T L  A    +
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581

Query: 624 TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683
            ++V  LL  G        +  T L  AA     ++  +LLQ+G   N    +G T L  
Sbjct: 582 LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641

Query: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
           AA  GH E+V  LL   A  N  +  G T L +      A +GH  V  +LI  G  VD 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV-----AQEGHVPVADVLIKHGVMVDA 696

Query: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803
             + G TPL VA++ G++ +V  LL+  ADV+     G +PL  AA  GH  +V  LL  
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756

Query: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
           GA+ + + S+G T L+IA   G + V   L
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 54/163 (33%), Positives = 86/163 (52%)

Query: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
            V  ++AD   +    A    L  A   L NG ++   +  G   LH++  +GH++MV  L
Sbjct: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
            +     +     +  +AL  AA  G  +VV+ L+ +GA V+    +G T L +AAQE H+
Sbjct: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
            +VV+ LLE+GA+ N A + G T + VA + GH  ++  L  YG
Sbjct: 125  EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  315 bits (808), Expect = 2e-85
 Identities = 206/601 (34%), Positives = 312/601 (51%), Gaps = 14/601 (2%)

Query: 524  REDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580
            R D  RT   LL N  + +     G T L  AA+  +L+V  LL++RGA +     +G T
Sbjct: 182  RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241

Query: 581  PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640
            PL +A+R+G+  +V  L+  GA I    +D  T L  AA  GH  +   LL  G  +   
Sbjct: 242  PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
              +  + +  AA G H D V  LLQ+ AE++    +  T L  AA+ GH  + + LLD G
Sbjct: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361

Query: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
            A+ N   ++G T L +A       K H  V+ LL+  GA +D   + G+TPL VA++ GH
Sbjct: 362  AKPNSRALNGFTPLHIAC-----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
            + +V  LL+ GA  + ++    TPL  AA  GH  V   LL   A V++   + +T L  
Sbjct: 417  LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476

Query: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
            A+  G+  +V+ LL+   + N    AG TPLH+AA EGH     AL+E+ A    +   G
Sbjct: 477  AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
              P  +A++ G     ++LLE  ++ +  G +G   L VA    + DIV+LL   G   +
Sbjct: 537  FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 941  CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA 1000
                +G   L+I A +NQ+ +A   L+ G +  A   +G T LH++  +GH EMV +L++
Sbjct: 597  SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 1001 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
              A+ N  +    + L   A +GHV V  +LI+HG +VD T   G T L +A+  G+I +
Sbjct: 657  KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKP 1120
            V+ LL+H AD N   + G + +  AA+ GH+ I+ LL K      NG SP+ V +    P
Sbjct: 717  VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK------NGASPNEVSSDGTTP 770

Query: 1121 L 1121
            L
Sbjct: 771  L 771



 Score =  286 bits (733), Expect = 8e-77
 Identities = 203/669 (30%), Positives = 322/669 (48%), Gaps = 49/669 (7%)

Query: 510  EDDRTSCIVRQALEREDSIRTLLD---NGASVNQCDSNGRTLLANAAYSGSLDVVNLLVS 566
            E D  +  +R A  R  ++   LD   NG  +N C+ NG   L  A+  G + +V  L+ 
Sbjct: 9    EADAATSFLRAA--RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66

Query: 567  RGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEV 626
            +   LE     G+T L +AA  G  +VV  L+  GAN+N   Q G+T L  AA   H EV
Sbjct: 67   KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 627  VSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE---------VNKADNEG 677
            V  LL  G   + A  D  T L  A   GHE++V +L+ +G +         +   +++ 
Sbjct: 127  VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186

Query: 678  RTALI--------------------AAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            RTA +                     AA+  +  + + LL+ GA VN    +G T L +A
Sbjct: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
                 + +G+  +V LL+DRGA+++   KD +TPL  AA  GHV + ++LL+ GA +   
Sbjct: 247  -----SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 778  DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
              NG +P+  AA   H   V  LL + A +D I  +  T L +A+  G+  V + LLD+G
Sbjct: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361

Query: 838  LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
               N R   G+TPLH+A  + H  + E L++ GA  + +   G  P  +AS  GH   V+
Sbjct: 362  AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421

Query: 898  ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
             LL+  ++ +         L +AA  GH ++ + L  + A VN K  D +  L+  A   
Sbjct: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
               M +  LEN AN   +   G T LH++  +GH+E V  L+   A       +  + L 
Sbjct: 482  HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541

Query: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
             AA  G V+V +LL+E  A  +     G T L +A    ++D+V++LL  G  P+     
Sbjct: 542  VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYG----ASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTI 1133
            G T + +AAK    ++ + L +YG    A S+ G   +P+H   Q+      +++ +L +
Sbjct: 602  GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEG----HAEMVALLL 655

Query: 1134 KSNSSGSTG 1142
               ++G+ G
Sbjct: 656  SKQANGNLG 664



 Score =  153 bits (386), Expect = 1e-36
 Identities = 123/390 (31%), Positives = 181/390 (46%), Gaps = 11/390 (2%)

Query: 447 LTPLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
           LTPL    F  HL I  NL    A   +  +   TP+  +         EV + L++  A
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA---GHTEVAKYLLQNKA 461

Query: 506 HVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
            VN++  DD+T       +   + ++ LL+N A+ N   + G T L  AA  G ++ V  
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
           L+ + A        G TPL +AA+ G  +V   L+   A+ N   ++G T L  A    +
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581

Query: 624 TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683
            ++V  LL  G        +  T L  AA     ++  +LLQ+G   N    +G T L  
Sbjct: 582 LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641

Query: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
           AA  GH E+V  LL   A  N  +  G T L +      A +GH  V  +LI  G  VD 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV-----AQEGHVPVADVLIKHGVMVDA 696

Query: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803
             + G TPL VA++ G++ +V  LL+  ADV+     G +PL  AA  GH  +V  LL  
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756

Query: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
           GA+ + + S+G T L+IA   G + V   L
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 54/163 (33%), Positives = 86/163 (52%)

Query: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
            V  ++AD   +    A    L  A   L NG ++   +  G   LH++  +GH++MV  L
Sbjct: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
            +     +     +  +AL  AA  G  +VV+ L+ +GA V+    +G T L +AAQE H+
Sbjct: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
            +VV+ LLE+GA+ N A + G T + VA + GH  ++  L  YG
Sbjct: 125  EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  315 bits (808), Expect = 2e-85
 Identities = 206/601 (34%), Positives = 312/601 (51%), Gaps = 14/601 (2%)

Query: 524  REDSIRT---LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHT 580
            R D  RT   LL N  + +     G T L  AA+  +L+V  LL++RGA +     +G T
Sbjct: 182  RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241

Query: 581  PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640
            PL +A+R+G+  +V  L+  GA I    +D  T L  AA  GH  +   LL  G  +   
Sbjct: 242  PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
              +  + +  AA G H D V  LLQ+ AE++    +  T L  AA+ GH  + + LLD G
Sbjct: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361

Query: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
            A+ N   ++G T L +A       K H  V+ LL+  GA +D   + G+TPL VA++ GH
Sbjct: 362  AKPNSRALNGFTPLHIAC-----KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416

Query: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
            + +V  LL+ GA  + ++    TPL  AA  GH  V   LL   A V++   + +T L  
Sbjct: 417  LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476

Query: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
            A+  G+  +V+ LL+   + N    AG TPLH+AA EGH     AL+E+ A    +   G
Sbjct: 477  AARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG 536

Query: 881  RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
              P  +A++ G     ++LLE  ++ +  G +G   L VA    + DIV+LL   G   +
Sbjct: 537  FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

Query: 941  CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIA 1000
                +G   L+I A +NQ+ +A   L+ G +  A   +G T LH++  +GH EMV +L++
Sbjct: 597  SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLS 656

Query: 1001 YHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
              A+ N  +    + L   A +GHV V  +LI+HG +VD T   G T L +A+  G+I +
Sbjct: 657  KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716

Query: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKP 1120
            V+ LL+H AD N   + G + +  AA+ GH+ I+ LL K      NG SP+ V +    P
Sbjct: 717  VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK------NGASPNEVSSDGTTP 770

Query: 1121 L 1121
            L
Sbjct: 771  L 771



 Score =  286 bits (733), Expect = 8e-77
 Identities = 203/669 (30%), Positives = 322/669 (48%), Gaps = 49/669 (7%)

Query: 510  EDDRTSCIVRQALEREDSIRTLLD---NGASVNQCDSNGRTLLANAAYSGSLDVVNLLVS 566
            E D  +  +R A  R  ++   LD   NG  +N C+ NG   L  A+  G + +V  L+ 
Sbjct: 9    EADAATSFLRAA--RSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH 66

Query: 567  RGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEV 626
            +   LE     G+T L +AA  G  +VV  L+  GAN+N   Q G+T L  AA   H EV
Sbjct: 67   KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126

Query: 627  VSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE---------VNKADNEG 677
            V  LL  G   + A  D  T L  A   GHE++V +L+ +G +         +   +++ 
Sbjct: 127  VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186

Query: 678  RTALI--------------------AAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            RTA +                     AA+  +  + + LL+ GA VN    +G T L +A
Sbjct: 187  RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
                 + +G+  +V LL+DRGA+++   KD +TPL  AA  GHV + ++LL+ GA +   
Sbjct: 247  -----SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 778  DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
              NG +P+  AA   H   V  LL + A +D I  +  T L +A+  G+  V + LLD+G
Sbjct: 302  TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361

Query: 838  LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
               N R   G+TPLH+A  + H  + E L++ GA  + +   G  P  +AS  GH   V+
Sbjct: 362  AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421

Query: 898  ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
             LL+  ++ +         L +AA  GH ++ + L  + A VN K  D +  L+  A   
Sbjct: 422  NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
               M +  LEN AN   +   G T LH++  +GH+E V  L+   A       +  + L 
Sbjct: 482  HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541

Query: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
             AA  G V+V +LL+E  A  +     G T L +A    ++D+V++LL  G  P+     
Sbjct: 542  VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN 601

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYG----ASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTI 1133
            G T + +AAK    ++ + L +YG    A S+ G   +P+H   Q+      +++ +L +
Sbjct: 602  GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV--TPLHLAAQEG----HAEMVALLL 655

Query: 1134 KSNSSGSTG 1142
               ++G+ G
Sbjct: 656  SKQANGNLG 664



 Score =  153 bits (386), Expect = 1e-36
 Identities = 123/390 (31%), Positives = 181/390 (46%), Gaps = 11/390 (2%)

Query: 447 LTPLEAQEFALHL-INSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
           LTPL    F  HL I  NL    A   +  +   TP+  +         EV + L++  A
Sbjct: 405 LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARA---GHTEVAKYLLQNKA 461

Query: 506 HVNSE--DDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
            VN++  DD+T       +   + ++ LL+N A+ N   + G T L  AA  G ++ V  
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLA 521

Query: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
           L+ + A        G TPL +AA+ G  +V   L+   A+ N   ++G T L  A    +
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581

Query: 624 TEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIA 683
            ++V  LL  G        +  T L  AA     ++  +LLQ+G   N    +G T L  
Sbjct: 582 LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641

Query: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
           AA  GH E+V  LL   A  N  +  G T L +      A +GH  V  +LI  G  VD 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV-----AQEGHVPVADVLIKHGVMVDA 696

Query: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803
             + G TPL VA++ G++ +V  LL+  ADV+     G +PL  AA  GH  +V  LL  
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756

Query: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
           GA+ + + S+G T L+IA   G + V   L
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 54/163 (33%), Positives = 86/163 (52%)

Query: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
            V  ++AD   +    A    L  A   L NG ++   +  G   LH++  +GH++MV  L
Sbjct: 5    VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
            +     +     +  +AL  AA  G  +VV+ L+ +GA V+    +G T L +AAQE H+
Sbjct: 65   LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124

Query: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYG 1101
            +VV+ LLE+GA+ N A + G T + VA + GH  ++  L  YG
Sbjct: 125  EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  308 bits (788), Expect = 3e-83
 Identities = 233/780 (29%), Positives = 363/780 (46%), Gaps = 51/780 (6%)

Query: 538  VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
            VN+   +G T L  AA+ G+++V  LL++RGA ++    +G TPL +A+++G+T +V  L
Sbjct: 205  VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264

Query: 598  IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
            +  G  I+   +DG T L  AA  GH +VV  LL  G  +     +  + L  AA G H 
Sbjct: 265  LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324

Query: 658  DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            + V +LLQH A V+    +  TAL  AA+ GH  + + LLD  A  N   ++G T L +A
Sbjct: 325  ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 384

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
                   K    V+ LL+  GA +    + G+TP+ VAA+ GH+++V LLL+ GA  D T
Sbjct: 385  C-----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 439

Query: 778  DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
            +  G T L  AA  G   VV  LL  GA VD+   E +T L IAS  G  E+V+ LL   
Sbjct: 440  NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499

Query: 838  LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
               +     G+TPLH++A EG   +   L+E GA  +     G  P  +A++ G  D  +
Sbjct: 500  AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 559

Query: 898  ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
            +LL+ ++  D  G +G   L VAA   ++ +  LL   GA  +    +G   L+I A +N
Sbjct: 560  LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 619

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
            Q+ +A   L  GA       +G T LH++  +GH +MV +L+   A+++ +     ++L 
Sbjct: 620  QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 679

Query: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
             AA +  V V  +L +HGA  D     G T L +A   G++ +V  LL+ GA+ N   + 
Sbjct: 680  LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 739

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNS 1137
            G T +  AA+ GH+ II +L ++GA   N  + +    +         S V +L + +  
Sbjct: 740  GYTPLHQAAQQGHTHIINVLLQHGAKP-NATTANGNTALAIAKRLGYISVVDTLKVVTEE 798

Query: 1138 SGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTV---------DRQKSSLSNNSLKSS- 1187
              +T     +     +P   T       E  D T+               L ++SL SS 
Sbjct: 799  VTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQ 858

Query: 1188 ---------------KNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSI 1232
                           ++ SLR+ SS         D  H LS    ++  ++       S+
Sbjct: 859  FLDGMNYLRYSLEGGRSDSLRSFSS---------DRSHTLSHASYLRDSAV----MDDSV 905

Query: 1233 VSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKSTKASKGGKSENSAKSGSAGKKAKQSNSS 1292
            V PS    +L +     S    W        +        S +   SG A    ++ NSS
Sbjct: 906  VIPSHQVSTLAKEAERNSYRLSWG-------TENLDNVALSSSPIHSGRASPCLERDNSS 958



 Score =  282 bits (721), Expect = 2e-75
 Identities = 195/587 (33%), Positives = 303/587 (51%), Gaps = 21/587 (3%)

Query: 538  VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
            + + DSN   L   AA +G+LD V   +  G D+   + +G   L LAA++GH  +V  L
Sbjct: 5    LQKSDSNASFL--RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQEL 62

Query: 598  IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
            +G G++++   + G TAL  A+  G  EVV  L+  G  ++    +  T L  AA   H 
Sbjct: 63   LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 122

Query: 658  DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            D+V  LL++GA  + A  +G T L  A   GH + V  LL++       D  G+  L   
Sbjct: 123  DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRL--P 173

Query: 718  ALCVPASKGHASVVSLLI--DRGAE------VDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
            AL + A K      +LL+  D  A+      V+   + G TPL +AA+ G+V+V  LLL 
Sbjct: 174  ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233

Query: 770  GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
             GA VD T  NG TPL  A+  G+ ++V  LL  G  +D+   +G T L  A+  G+ +V
Sbjct: 234  RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 293

Query: 830  VRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQ 889
            V  LL+RG     R   G +PLHMAA   H    + L++  A  +++  D      +A+ 
Sbjct: 294  VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAH 353

Query: 890  EGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT 949
             GHY   ++LL+ ++N + R  +G   L +A  +    ++ELL  +GA +      G   
Sbjct: 354  CGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTP 413

Query: 950  LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
            +++ A    L +    L+NGA+ + ++  G TALH++   G +E+V+ L+   A V+A  
Sbjct: 414  IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473

Query: 1010 NEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGA 1069
             E+++ L  A+  G  ++VQLL++H A  D     G T L I+A+EG +DV  VLLE GA
Sbjct: 474  REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533

Query: 1070 DPNHADQFGRTAMRVAAKNGHSQIIKLL--EKYGASSLNGCSPSPVH 1114
              + A + G T + VAAK G   + KLL   +  A S      +P+H
Sbjct: 534  AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580



 Score =  281 bits (719), Expect = 3e-75
 Identities = 200/633 (31%), Positives = 303/633 (47%), Gaps = 44/633 (6%)

Query: 526  DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
            D +   L  G  +N C+ NG   L  AA  G + +V  L+ RG+ ++     G+T L +A
Sbjct: 24   DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIA 83

Query: 586  ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR 645
            +  G  +VV  L+  GANIN   Q+G+T L  AA   H +VV  LL  G     A  D  
Sbjct: 84   SLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGF 143

Query: 646  TALRAAAWGGHEDIVLNLLQ-------------------------------HGAE----- 669
            T L  A   GH   V  LL+                               H A+     
Sbjct: 144  TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 203

Query: 670  -VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
             VN+    G T L  AA+ G+  +   LL+ GA V+    +G T L VA     + +G+ 
Sbjct: 204  MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA-----SKRGNT 258

Query: 729  SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
            ++V LL+DRG ++D   +DG+TPL  AA  GH  VV+LLLE GA +     NG +PL  A
Sbjct: 259  NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 318

Query: 789  ASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGW 848
            A   H   V  LL   A VD +  +  T L +A+  G+  V + LLD+  + N R   G+
Sbjct: 319  AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF 378

Query: 849  TPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQ 908
            TPLH+A  +    + E L++ GA    I   G  P  +A+  GH + V +LL+N ++ D 
Sbjct: 379  TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438

Query: 909  RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLEN 968
                G  AL +AA  G  ++V  L  +GA V+ +  + +  L+I +   +  + +  L++
Sbjct: 439  TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498

Query: 969  GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 1028
             A+ +A+   G T LH+S  +G +++  VL+   A  + A  +  + L  AA  G + V 
Sbjct: 499  MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558

Query: 1029 QLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKN 1088
            +LL++  A  D     G T L +AA   +  V  +LLE GA P+   + G T + +AAK 
Sbjct: 559  KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 618

Query: 1089 GHSQIIKLLEKYGASS--LNGCSPSPVHTMEQK 1119
               QI   L  YGA +  +     +P+H   Q+
Sbjct: 619  NQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 651



 Score =  256 bits (654), Expect = 1e-67
 Identities = 185/562 (32%), Positives = 255/562 (45%), Gaps = 61/562 (10%)

Query: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
            LL+ GA+V+    NG T L  A+  G+ ++V LL+ RG  ++ +   G TPL  AAR GH
Sbjct: 231  LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 290

Query: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
             +VV  L+  GA +    ++G + L  AA G H E V  LL     VD    D  TAL  
Sbjct: 291  DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 350

Query: 651  AAWGGHEDIV--------------LN-------------------LLQHGAEVNKADNEG 677
            AA  GH  +               LN                   L+++GA +      G
Sbjct: 351  AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410

Query: 678  RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA------------------- 718
             T +  AA+MGH  IV  LL +GA  +  ++ G TAL +AA                   
Sbjct: 411  LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470

Query: 719  ---------LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
                     L + +  G   +V LL+   A  D    +G TPL ++A EG VDV  +LLE
Sbjct: 471  ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530

Query: 770  GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
             GA        G TPL  AA  G   V   LL   AA DS    G T L +A+   N +V
Sbjct: 531  AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 590

Query: 830  VRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQ 889
               LL++G   +     G+TPLH+AA +    I   L+  GA TN +   G  P  LASQ
Sbjct: 591  ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 650

Query: 890  EGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT 949
            EGH D V +LL+  +NI      G  +L +AA E   ++ ++L  HGAD +     G   
Sbjct: 651  EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 710

Query: 950  LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
            L +      + M  + L+ GANV A    G T LH +  QGH  ++ VL+ + A  NA  
Sbjct: 711  LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 770

Query: 1010 NEKRSALQSAAWQGHVKVVQLL 1031
                +AL  A   G++ VV  L
Sbjct: 771  ANGNTALAIAKRLGYISVVDTL 792



 Score =  222 bits (566), Expect = 2e-57
 Identities = 160/506 (31%), Positives = 249/506 (49%), Gaps = 7/506 (1%)

Query: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
           +V++LL++ GA + +        +  A + +  + ++ LL + A V+    +  T L  A
Sbjct: 292 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 351

Query: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
           A+ G   V  LL+ + A+      +G TPL +A ++   KV+  L+  GA+I    + G 
Sbjct: 352 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL 411

Query: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
           T +  AA+ GH  +V  LL  G   D  +    TAL  AA  G  ++V  LL++GA V+ 
Sbjct: 412 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 471

Query: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
              E +T L  A+ +G  EIV+ LL H A  +    +G T L ++     A +G   V S
Sbjct: 472 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS-----AREGQVDVAS 526

Query: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792
           +L++ GA      K G TPL VAA  G +DV  LLL+  A  D    NG TPL  AA   
Sbjct: 527 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 586

Query: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852
           +  V   LL  GA+  +    G T L IA+ +  +++  TLL+ G + N     G TPLH
Sbjct: 587 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 646

Query: 853 MAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYD 912
           +A+ EGH  +   L+++GA  +     G     LA+QE   +   IL ++ ++ D     
Sbjct: 647 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 706

Query: 913 GRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANV 972
           G   L VA   G+  +V  L   GA+VN K  +G   L+  A +    +    L++GA  
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766

Query: 973 EASDAEGRTALHVSCWQGHMEMVQVL 998
            A+ A G TAL ++   G++ +V  L
Sbjct: 767 NATTANGNTALAIAKRLGYISVVDTL 792



 Score =  191 bits (486), Expect = 3e-48
 Identities = 140/404 (34%), Positives = 201/404 (49%), Gaps = 22/404 (5%)

Query: 747  DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
            D     L AA  G++D V   L+GG D++  + NG   L  AA  GH  +V  LL  G++
Sbjct: 9    DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68

Query: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
            VDS   +G T L IAS  G  EVV+ L+  G + N +   G+TPL+MAA E H  + + L
Sbjct: 69   VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 867  IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
            +E GA  +    DG  P  +A Q+GH   V ILLEN    D +G     AL +AA +   
Sbjct: 129  LENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDT 184

Query: 927  DIVELLF--SHGADVNCKDADGRPT------LYILALENQLTMAEYFLENGANVEASDAE 978
                LL    H ADV  K    R T      L+I A    + +A   L  GA V+ +   
Sbjct: 185  KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 244

Query: 979  GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038
            G T LHV+  +G+  MV++L+     ++A   +  + L  AA  GH +VV+LL+E GA +
Sbjct: 245  GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304

Query: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL- 1097
                  G + L +AAQ  H++ V+ LL+H A  +       TA+ VAA  GH ++ KLL 
Sbjct: 305  LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 364

Query: 1098 ---EKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138
                   A +LNG +P  +   + +       KV  L +K  +S
Sbjct: 365  DKRANPNARALNGFTPLHIACKKNR------IKVMELLVKYGAS 402


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  307 bits (786), Expect = 5e-83
 Identities = 226/743 (30%), Positives = 352/743 (47%), Gaps = 44/743 (5%)

Query: 538  VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
            VN+   +G T L  AA+ G+++V  LL++RGA ++    +G TPL +A+++G+T +V  L
Sbjct: 226  VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285

Query: 598  IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
            +  G  I+   +DG T L  AA  GH +VV  LL  G  +     +  + L  AA G H 
Sbjct: 286  LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345

Query: 658  DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            + V +LLQH A V+    +  TAL  AA+ GH  + + LLD  A  N   ++G T L +A
Sbjct: 346  ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
                   K    V+ LL+  GA +    + G+TP+ VAA+ GH+++V LLL+ GA  D T
Sbjct: 406  C-----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460

Query: 778  DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
            +  G T L  AA  G   VV  LL  GA VD+   E +T L IAS  G  E+V+ LL   
Sbjct: 461  NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520

Query: 838  LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
               +     G+TPLH++A EG   +   L+E GA  +     G  P  +A++ G  D  +
Sbjct: 521  AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580

Query: 898  ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
            +LL+ ++  D  G +G   L VAA   ++ +  LL   GA  +    +G   L+I A +N
Sbjct: 581  LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
            Q+ +A   L  GA       +G T LH++  +GH +MV +L+   A+++ +     ++L 
Sbjct: 641  QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 700

Query: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
             AA +  V V  +L +HGA  D     G T L +A   G++ +V  LL+ GA+ N   + 
Sbjct: 701  LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 760

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNS 1137
            G T +  AA+ GH+ II +L ++GA   N  + +    +         S V +L + +  
Sbjct: 761  GYTPLHQAAQQGHTHIINVLLQHGAKP-NATTANGNTALAIAKRLGYISVVDTLKVVTEE 819

Query: 1138 SGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTV---------DRQKSSLSNNSLKSS- 1187
              +T     +     +P   T       E  D T+               L ++SL SS 
Sbjct: 820  VTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQ 879

Query: 1188 ---------------KNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSI 1232
                           ++ SLR+ SS         D  H LS    ++  ++       S+
Sbjct: 880  FLDGMNYLRYSLEGGRSDSLRSFSS---------DRSHTLSHASYLRDSAV----MDDSV 926

Query: 1233 VSPSSTTQSLGQSHNSPSSEFEW 1255
            V PS    +L +     S    W
Sbjct: 927  VIPSHQVSTLAKEAERNSYRLSW 949



 Score =  281 bits (720), Expect = 2e-75
 Identities = 195/583 (33%), Positives = 301/583 (51%), Gaps = 21/583 (3%)

Query: 542  DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601
            DSN   L   AA +G+LD V   +  G D+   + +G   L LAA++GH  +V  L+G G
Sbjct: 30   DSNASFL--RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87

Query: 602  ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661
            ++++   + G TAL  A+  G  EVV  L+  G  ++    +  T L  AA   H D+V 
Sbjct: 88   SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147

Query: 662  NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721
             LL++GA  + A  +G T L  A   GH + V  LL++       D  G+  L   AL +
Sbjct: 148  YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRL--PALHI 198

Query: 722  PASKGHASVVSLLI--DRGAE------VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD 773
             A K      +LL+  D  A+      V+   + G TPL +AA+ G+V+V  LLL  GA 
Sbjct: 199  AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258

Query: 774  VDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
            VD T  NG TPL  A+  G+ ++V  LL  G  +D+   +G T L  A+  G+ +VV  L
Sbjct: 259  VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318

Query: 834  LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHY 893
            L+RG     R   G +PLHMAA   H    + L++  A  +++  D      +A+  GHY
Sbjct: 319  LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378

Query: 894  DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953
               ++LL+ ++N + R  +G   L +A  +    ++ELL  +GA +      G   +++ 
Sbjct: 379  RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438

Query: 954  ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013
            A    L +    L+NGA+ + ++  G TALH++   G +E+V+ L+   A V+A   E++
Sbjct: 439  AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498

Query: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073
            + L  A+  G  ++VQLL++H A  D     G T L I+A+EG +DV  VLLE GA  + 
Sbjct: 499  TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558

Query: 1074 ADQFGRTAMRVAAKNGHSQIIKLL--EKYGASSLNGCSPSPVH 1114
            A + G T + VAAK G   + KLL   +  A S      +P+H
Sbjct: 559  ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601



 Score =  281 bits (719), Expect = 3e-75
 Identities = 200/633 (31%), Positives = 303/633 (47%), Gaps = 44/633 (6%)

Query: 526  DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
            D +   L  G  +N C+ NG   L  AA  G + +V  L+ RG+ ++     G+T L +A
Sbjct: 45   DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIA 104

Query: 586  ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR 645
            +  G  +VV  L+  GANIN   Q+G+T L  AA   H +VV  LL  G     A  D  
Sbjct: 105  SLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGF 164

Query: 646  TALRAAAWGGHEDIVLNLLQ-------------------------------HGAE----- 669
            T L  A   GH   V  LL+                               H A+     
Sbjct: 165  TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 224

Query: 670  -VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
             VN+    G T L  AA+ G+  +   LL+ GA V+    +G T L VA     + +G+ 
Sbjct: 225  MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA-----SKRGNT 279

Query: 729  SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
            ++V LL+DRG ++D   +DG+TPL  AA  GH  VV+LLLE GA +     NG +PL  A
Sbjct: 280  NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339

Query: 789  ASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGW 848
            A   H   V  LL   A VD +  +  T L +A+  G+  V + LLD+  + N R   G+
Sbjct: 340  AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF 399

Query: 849  TPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQ 908
            TPLH+A  +    + E L++ GA    I   G  P  +A+  GH + V +LL+N ++ D 
Sbjct: 400  TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 909  RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLEN 968
                G  AL +AA  G  ++V  L  +GA V+ +  + +  L+I +   +  + +  L++
Sbjct: 460  TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 969  GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 1028
             A+ +A+   G T LH+S  +G +++  VL+   A  + A  +  + L  AA  G + V 
Sbjct: 520  MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579

Query: 1029 QLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKN 1088
            +LL++  A  D     G T L +AA   +  V  +LLE GA P+   + G T + +AAK 
Sbjct: 580  KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639

Query: 1089 GHSQIIKLLEKYGASS--LNGCSPSPVHTMEQK 1119
               QI   L  YGA +  +     +P+H   Q+
Sbjct: 640  NQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672



 Score =  256 bits (654), Expect = 1e-67
 Identities = 185/562 (32%), Positives = 255/562 (45%), Gaps = 61/562 (10%)

Query: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
            LL+ GA+V+    NG T L  A+  G+ ++V LL+ RG  ++ +   G TPL  AAR GH
Sbjct: 252  LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311

Query: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
             +VV  L+  GA +    ++G + L  AA G H E V  LL     VD    D  TAL  
Sbjct: 312  DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371

Query: 651  AAWGGHEDIV--------------LN-------------------LLQHGAEVNKADNEG 677
            AA  GH  +               LN                   L+++GA +      G
Sbjct: 372  AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 678  RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA------------------- 718
             T +  AA+MGH  IV  LL +GA  +  ++ G TAL +AA                   
Sbjct: 432  LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 719  ---------LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
                     L + +  G   +V LL+   A  D    +G TPL ++A EG VDV  +LLE
Sbjct: 492  ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551

Query: 770  GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
             GA        G TPL  AA  G   V   LL   AA DS    G T L +A+   N +V
Sbjct: 552  AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611

Query: 830  VRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQ 889
               LL++G   +     G+TPLH+AA +    I   L+  GA TN +   G  P  LASQ
Sbjct: 612  ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671

Query: 890  EGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT 949
            EGH D V +LL+  +NI      G  +L +AA E   ++ ++L  HGAD +     G   
Sbjct: 672  EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731

Query: 950  LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
            L +      + M  + L+ GANV A    G T LH +  QGH  ++ VL+ + A  NA  
Sbjct: 732  LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791

Query: 1010 NEKRSALQSAAWQGHVKVVQLL 1031
                +AL  A   G++ VV  L
Sbjct: 792  ANGNTALAIAKRLGYISVVDTL 813



 Score =  234 bits (598), Expect = 3e-61
 Identities = 168/532 (31%), Positives = 254/532 (47%), Gaps = 75/532 (14%)

Query: 642  ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701
            +DS  +   AA  G+ D V+  L+ G ++N  +  G  AL  AA  GH  +V+ LL  G+
Sbjct: 29   SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 702  EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761
             V+     G TAL +A+L      G A VV +L+  GA ++   ++G TPL +AA E H+
Sbjct: 89   SVDSATKKGNTALHIASLA-----GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143

Query: 762  DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL-------------------- 801
            DVV  LLE GA+      +G TPL  A   GH   V  LL                    
Sbjct: 144  DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203

Query: 802  -FWGAA----------------VDSIDSEGRTVLSIASAQGNVEVVRTLLDRG------- 837
                AA                V+     G T L IA+  GNV V   LL+RG       
Sbjct: 204  DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263

Query: 838  ----------------------LDENHRDDA----GWTPLHMAAFEGHRLICEALIEQGA 871
                                  LD   + DA    G TPLH AA  GH  + E L+E+GA
Sbjct: 264  RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323

Query: 872  RTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL 931
                   +G  P  +A+Q  H +CV+ LL++K+ +D    D   AL VAA  GH  + +L
Sbjct: 324  PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383

Query: 932  LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGH 991
            L    A+ N +  +G   L+I   +N++ + E  ++ GA+++A    G T +HV+ + GH
Sbjct: 384  LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443

Query: 992  MEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCI 1051
            + +V +L+   A  +  +    +AL  AA  G V+VV+ L+ +GA+VD    +  T L I
Sbjct: 444  LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503

Query: 1052 AAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
            A++ G  ++VQ+LL+H A P+ A   G T + ++A+ G   +  +L + GA+
Sbjct: 504  ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555



 Score =  222 bits (566), Expect = 2e-57
 Identities = 160/506 (31%), Positives = 249/506 (49%), Gaps = 7/506 (1%)

Query: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
           +V++LL++ GA + +        +  A + +  + ++ LL + A V+    +  T L  A
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372

Query: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
           A+ G   V  LL+ + A+      +G TPL +A ++   KV+  L+  GA+I    + G 
Sbjct: 373 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL 432

Query: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
           T +  AA+ GH  +V  LL  G   D  +    TAL  AA  G  ++V  LL++GA V+ 
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492

Query: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
              E +T L  A+ +G  EIV+ LL H A  +    +G T L ++     A +G   V S
Sbjct: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS-----AREGQVDVAS 547

Query: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792
           +L++ GA      K G TPL VAA  G +DV  LLL+  A  D    NG TPL  AA   
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607

Query: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852
           +  V   LL  GA+  +    G T L IA+ +  +++  TLL+ G + N     G TPLH
Sbjct: 608 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667

Query: 853 MAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYD 912
           +A+ EGH  +   L+++GA  +     G     LA+QE   +   IL ++ ++ D     
Sbjct: 668 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 727

Query: 913 GRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANV 972
           G   L VA   G+  +V  L   GA+VN K  +G   L+  A +    +    L++GA  
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787

Query: 973 EASDAEGRTALHVSCWQGHMEMVQVL 998
            A+ A G TAL ++   G++ +V  L
Sbjct: 788 NATTANGNTALAIAKRLGYISVVDTL 813



 Score =  191 bits (486), Expect = 3e-48
 Identities = 140/404 (34%), Positives = 201/404 (49%), Gaps = 22/404 (5%)

Query: 747  DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
            D     L AA  G++D V   L+GG D++  + NG   L  AA  GH  +V  LL  G++
Sbjct: 30   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
            VDS   +G T L IAS  G  EVV+ L+  G + N +   G+TPL+MAA E H  + + L
Sbjct: 90   VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 867  IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
            +E GA  +    DG  P  +A Q+GH   V ILLEN    D +G     AL +AA +   
Sbjct: 150  LENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDT 205

Query: 927  DIVELLF--SHGADVNCKDADGRPT------LYILALENQLTMAEYFLENGANVEASDAE 978
                LL    H ADV  K    R T      L+I A    + +A   L  GA V+ +   
Sbjct: 206  KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265

Query: 979  GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038
            G T LHV+  +G+  MV++L+     ++A   +  + L  AA  GH +VV+LL+E GA +
Sbjct: 266  GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325

Query: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL- 1097
                  G + L +AAQ  H++ V+ LL+H A  +       TA+ VAA  GH ++ KLL 
Sbjct: 326  LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 385

Query: 1098 ---EKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138
                   A +LNG +P  +   + +       KV  L +K  +S
Sbjct: 386  DKRANPNARALNGFTPLHIACKKNR------IKVMELLVKYGAS 423



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 52/156 (33%), Positives = 89/156 (57%)

Query: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
            K +D   +    A    L     +L+ G ++   +  G  ALH++  +GH+ +VQ L+  
Sbjct: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061
             + V++A  +  +AL  A+  G  +VV++L++ GA ++     G T L +AAQE HIDVV
Sbjct: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
            + LLE+GA+ + A + G T + VA + GH+Q + +L
Sbjct: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  307 bits (786), Expect = 5e-83
 Identities = 226/743 (30%), Positives = 352/743 (47%), Gaps = 44/743 (5%)

Query: 538  VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
            VN+   +G T L  AA+ G+++V  LL++RGA ++    +G TPL +A+++G+T +V  L
Sbjct: 226  VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285

Query: 598  IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
            +  G  I+   +DG T L  AA  GH +VV  LL  G  +     +  + L  AA G H 
Sbjct: 286  LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345

Query: 658  DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            + V +LLQH A V+    +  TAL  AA+ GH  + + LLD  A  N   ++G T L +A
Sbjct: 346  ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
                   K    V+ LL+  GA +    + G+TP+ VAA+ GH+++V LLL+ GA  D T
Sbjct: 406  C-----KKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVT 460

Query: 778  DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
            +  G T L  AA  G   VV  LL  GA VD+   E +T L IAS  G  E+V+ LL   
Sbjct: 461  NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520

Query: 838  LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
               +     G+TPLH++A EG   +   L+E GA  +     G  P  +A++ G  D  +
Sbjct: 521  AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580

Query: 898  ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
            +LL+ ++  D  G +G   L VAA   ++ +  LL   GA  +    +G   L+I A +N
Sbjct: 581  LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
            Q+ +A   L  GA       +G T LH++  +GH +MV +L+   A+++ +     ++L 
Sbjct: 641  QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 700

Query: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
             AA +  V V  +L +HGA  D     G T L +A   G++ +V  LL+ GA+ N   + 
Sbjct: 701  LAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 760

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNS 1137
            G T +  AA+ GH+ II +L ++GA   N  + +    +         S V +L + +  
Sbjct: 761  GYTPLHQAAQQGHTHIINVLLQHGAKP-NATTANGNTALAIAKRLGYISVVDTLKVVTEE 819

Query: 1138 SGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTV---------DRQKSSLSNNSLKSS- 1187
              +T     +     +P   T       E  D T+               L ++SL SS 
Sbjct: 820  VTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQ 879

Query: 1188 ---------------KNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLPRSRSRQSI 1232
                           ++ SLR+ SS         D  H LS    ++  ++       S+
Sbjct: 880  FLDGMNYLRYSLEGGRSDSLRSFSS---------DRSHTLSHASYLRDSAV----MDDSV 926

Query: 1233 VSPSSTTQSLGQSHNSPSSEFEW 1255
            V PS    +L +     S    W
Sbjct: 927  VIPSHQVSTLAKEAERNSYRLSW 949



 Score =  281 bits (720), Expect = 2e-75
 Identities = 195/583 (33%), Positives = 301/583 (51%), Gaps = 21/583 (3%)

Query: 542  DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601
            DSN   L   AA +G+LD V   +  G D+   + +G   L LAA++GH  +V  L+G G
Sbjct: 30   DSNASFL--RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87

Query: 602  ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661
            ++++   + G TAL  A+  G  EVV  L+  G  ++    +  T L  AA   H D+V 
Sbjct: 88   SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147

Query: 662  NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721
             LL++GA  + A  +G T L  A   GH + V  LL++       D  G+  L   AL +
Sbjct: 148  YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN-------DTKGKVRL--PALHI 198

Query: 722  PASKGHASVVSLLI--DRGAE------VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD 773
             A K      +LL+  D  A+      V+   + G TPL +AA+ G+V+V  LLL  GA 
Sbjct: 199  AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258

Query: 774  VDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
            VD T  NG TPL  A+  G+ ++V  LL  G  +D+   +G T L  A+  G+ +VV  L
Sbjct: 259  VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318

Query: 834  LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHY 893
            L+RG     R   G +PLHMAA   H    + L++  A  +++  D      +A+  GHY
Sbjct: 319  LERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHY 378

Query: 894  DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953
               ++LL+ ++N + R  +G   L +A  +    ++ELL  +GA +      G   +++ 
Sbjct: 379  RVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438

Query: 954  ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013
            A    L +    L+NGA+ + ++  G TALH++   G +E+V+ L+   A V+A   E++
Sbjct: 439  AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ 498

Query: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073
            + L  A+  G  ++VQLL++H A  D     G T L I+A+EG +DV  VLLE GA  + 
Sbjct: 499  TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSL 558

Query: 1074 ADQFGRTAMRVAAKNGHSQIIKLL--EKYGASSLNGCSPSPVH 1114
            A + G T + VAAK G   + KLL   +  A S      +P+H
Sbjct: 559  ATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601



 Score =  281 bits (719), Expect = 3e-75
 Identities = 200/633 (31%), Positives = 303/633 (47%), Gaps = 44/633 (6%)

Query: 526  DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
            D +   L  G  +N C+ NG   L  AA  G + +V  L+ RG+ ++     G+T L +A
Sbjct: 45   DKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIA 104

Query: 586  ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR 645
            +  G  +VV  L+  GANIN   Q+G+T L  AA   H +VV  LL  G     A  D  
Sbjct: 105  SLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGF 164

Query: 646  TALRAAAWGGHEDIVLNLLQ-------------------------------HGAE----- 669
            T L  A   GH   V  LL+                               H A+     
Sbjct: 165  TPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKM 224

Query: 670  -VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
             VN+    G T L  AA+ G+  +   LL+ GA V+    +G T L VA     + +G+ 
Sbjct: 225  MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVA-----SKRGNT 279

Query: 729  SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
            ++V LL+DRG ++D   +DG+TPL  AA  GH  VV+LLLE GA +     NG +PL  A
Sbjct: 280  NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339

Query: 789  ASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGW 848
            A   H   V  LL   A VD +  +  T L +A+  G+  V + LLD+  + N R   G+
Sbjct: 340  AQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGF 399

Query: 849  TPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQ 908
            TPLH+A  +    + E L++ GA    I   G  P  +A+  GH + V +LL+N ++ D 
Sbjct: 400  TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 909  RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLEN 968
                G  AL +AA  G  ++V  L  +GA V+ +  + +  L+I +   +  + +  L++
Sbjct: 460  TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 969  GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 1028
             A+ +A+   G T LH+S  +G +++  VL+   A  + A  +  + L  AA  G + V 
Sbjct: 520  MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579

Query: 1029 QLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKN 1088
            +LL++  A  D     G T L +AA   +  V  +LLE GA P+   + G T + +AAK 
Sbjct: 580  KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639

Query: 1089 GHSQIIKLLEKYGASS--LNGCSPSPVHTMEQK 1119
               QI   L  YGA +  +     +P+H   Q+
Sbjct: 640  NQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672



 Score =  256 bits (654), Expect = 1e-67
 Identities = 185/562 (32%), Positives = 255/562 (45%), Gaps = 61/562 (10%)

Query: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
            LL+ GA+V+    NG T L  A+  G+ ++V LL+ RG  ++ +   G TPL  AAR GH
Sbjct: 252  LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311

Query: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
             +VV  L+  GA +    ++G + L  AA G H E V  LL     VD    D  TAL  
Sbjct: 312  DQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHV 371

Query: 651  AAWGGHEDIV--------------LN-------------------LLQHGAEVNKADNEG 677
            AA  GH  +               LN                   L+++GA +      G
Sbjct: 372  AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 678  RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA------------------- 718
             T +  AA+MGH  IV  LL +GA  +  ++ G TAL +AA                   
Sbjct: 432  LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 719  ---------LCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
                     L + +  G   +V LL+   A  D    +G TPL ++A EG VDV  +LLE
Sbjct: 492  ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551

Query: 770  GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
             GA        G TPL  AA  G   V   LL   AA DS    G T L +A+   N +V
Sbjct: 552  AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611

Query: 830  VRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQ 889
               LL++G   +     G+TPLH+AA +    I   L+  GA TN +   G  P  LASQ
Sbjct: 612  ALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQ 671

Query: 890  EGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT 949
            EGH D V +LL+  +NI      G  +L +AA E   ++ ++L  HGAD +     G   
Sbjct: 672  EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731

Query: 950  LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
            L +      + M  + L+ GANV A    G T LH +  QGH  ++ VL+ + A  NA  
Sbjct: 732  LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791

Query: 1010 NEKRSALQSAAWQGHVKVVQLL 1031
                +AL  A   G++ VV  L
Sbjct: 792  ANGNTALAIAKRLGYISVVDTL 813



 Score =  234 bits (598), Expect = 3e-61
 Identities = 168/532 (31%), Positives = 254/532 (47%), Gaps = 75/532 (14%)

Query: 642  ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701
            +DS  +   AA  G+ D V+  L+ G ++N  +  G  AL  AA  GH  +V+ LL  G+
Sbjct: 29   SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 702  EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761
             V+     G TAL +A+L      G A VV +L+  GA ++   ++G TPL +AA E H+
Sbjct: 89   SVDSATKKGNTALHIASLA-----GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143

Query: 762  DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL-------------------- 801
            DVV  LLE GA+      +G TPL  A   GH   V  LL                    
Sbjct: 144  DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203

Query: 802  -FWGAA----------------VDSIDSEGRTVLSIASAQGNVEVVRTLLDRG------- 837
                AA                V+     G T L IA+  GNV V   LL+RG       
Sbjct: 204  DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263

Query: 838  ----------------------LDENHRDDA----GWTPLHMAAFEGHRLICEALIEQGA 871
                                  LD   + DA    G TPLH AA  GH  + E L+E+GA
Sbjct: 264  RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323

Query: 872  RTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL 931
                   +G  P  +A+Q  H +CV+ LL++K+ +D    D   AL VAA  GH  + +L
Sbjct: 324  PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383

Query: 932  LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGH 991
            L    A+ N +  +G   L+I   +N++ + E  ++ GA+++A    G T +HV+ + GH
Sbjct: 384  LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443

Query: 992  MEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCI 1051
            + +V +L+   A  +  +    +AL  AA  G V+VV+ L+ +GA+VD    +  T L I
Sbjct: 444  LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503

Query: 1052 AAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
            A++ G  ++VQ+LL+H A P+ A   G T + ++A+ G   +  +L + GA+
Sbjct: 504  ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555



 Score =  222 bits (566), Expect = 2e-57
 Identities = 160/506 (31%), Positives = 249/506 (49%), Gaps = 7/506 (1%)

Query: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
           +V++LL++ GA + +        +  A + +  + ++ LL + A V+    +  T L  A
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372

Query: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
           A+ G   V  LL+ + A+      +G TPL +A ++   KV+  L+  GA+I    + G 
Sbjct: 373 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL 432

Query: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
           T +  AA+ GH  +V  LL  G   D  +    TAL  AA  G  ++V  LL++GA V+ 
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492

Query: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
              E +T L  A+ +G  EIV+ LL H A  +    +G T L ++     A +G   V S
Sbjct: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS-----AREGQVDVAS 547

Query: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792
           +L++ GA      K G TPL VAA  G +DV  LLL+  A  D    NG TPL  AA   
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607

Query: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852
           +  V   LL  GA+  +    G T L IA+ +  +++  TLL+ G + N     G TPLH
Sbjct: 608 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 667

Query: 853 MAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYD 912
           +A+ EGH  +   L+++GA  +     G     LA+QE   +   IL ++ ++ D     
Sbjct: 668 LASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL 727

Query: 913 GRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANV 972
           G   L VA   G+  +V  L   GA+VN K  +G   L+  A +    +    L++GA  
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787

Query: 973 EASDAEGRTALHVSCWQGHMEMVQVL 998
            A+ A G TAL ++   G++ +V  L
Sbjct: 788 NATTANGNTALAIAKRLGYISVVDTL 813



 Score =  191 bits (486), Expect = 3e-48
 Identities = 140/404 (34%), Positives = 201/404 (49%), Gaps = 22/404 (5%)

Query: 747  DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
            D     L AA  G++D V   L+GG D++  + NG   L  AA  GH  +V  LL  G++
Sbjct: 30   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
            VDS   +G T L IAS  G  EVV+ L+  G + N +   G+TPL+MAA E H  + + L
Sbjct: 90   VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 867  IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
            +E GA  +    DG  P  +A Q+GH   V ILLEN    D +G     AL +AA +   
Sbjct: 150  LENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN----DTKGKVRLPALHIAARKDDT 205

Query: 927  DIVELLF--SHGADVNCKDADGRPT------LYILALENQLTMAEYFLENGANVEASDAE 978
                LL    H ADV  K    R T      L+I A    + +A   L  GA V+ +   
Sbjct: 206  KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265

Query: 979  GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038
            G T LHV+  +G+  MV++L+     ++A   +  + L  AA  GH +VV+LL+E GA +
Sbjct: 266  GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325

Query: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL- 1097
                  G + L +AAQ  H++ V+ LL+H A  +       TA+ VAA  GH ++ KLL 
Sbjct: 326  LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 385

Query: 1098 ---EKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138
                   A +LNG +P  +   + +       KV  L +K  +S
Sbjct: 386  DKRANPNARALNGFTPLHIACKKNR------IKVMELLVKYGAS 423



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 52/156 (33%), Positives = 89/156 (57%)

Query: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
            K +D   +    A    L     +L+ G ++   +  G  ALH++  +GH+ +VQ L+  
Sbjct: 27   KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVV 1061
             + V++A  +  +AL  A+  G  +VV++L++ GA ++     G T L +AAQE HIDVV
Sbjct: 87   GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 1062 QVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
            + LLE+GA+ + A + G T + VA + GH+Q + +L
Sbjct: 147  KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL 182


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  303 bits (776), Expect = 8e-82
 Identities = 226/708 (31%), Positives = 348/708 (49%), Gaps = 56/708 (7%)

Query: 441  TCQAKNLTPLEAQEFA-----LHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQE 495
            T  ++  TPL    F      + L+  +     A+  +W+    TP+  ++++   + +E
Sbjct: 11   TLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL----TPLHRAVAS---RSEE 63

Query: 496  VLQLLVKAGAHVNSEDD--RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAA 553
             +Q+L+K  A VN+ D   +T   V  A +       ++   +SVN  D  GRT L +AA
Sbjct: 64   AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123

Query: 554  YSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWT 613
             +G +++VNLL+++GA++   D      L  AA  GH  VV  LI  GA +   D+ G+T
Sbjct: 124  LNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT 183

Query: 614  ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673
             L +AA  G   VV  LL  GV++D  +    TAL  A + G + +V  L+ +GA VN+ 
Sbjct: 184  PLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP 243

Query: 674  DNEGRTALIAAAYMGHREI-VEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
            +N G T L  AA   H  + +E L+++GA+VN +  DG++ L + A+      G  +   
Sbjct: 244  NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV-----HGRFTRSQ 298

Query: 733  LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792
             LI  G E+D  DKDG TPL VAA  GH  +++ L   GAD      +   PL  AA   
Sbjct: 299  TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358

Query: 793  HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852
            H+     LL  G  +D+ D  GRT L  A+A GNVE ++ L   G D + +D  G TPLH
Sbjct: 359  HSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLH 418

Query: 853  MAAFEGHRLICEALIEQGARTNEIDNDGRIPF-------------ILASQEGHYD----- 894
             AA   H    E L+  GA  NE D+ GR                IL +   + +     
Sbjct: 419  YAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERA 478

Query: 895  ----------CVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDA 944
                      C++ LL+N +N   R  +G N++  AA  GHR  +ELL     +   +++
Sbjct: 479  RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEES 537

Query: 945  DGRPT---LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
            D   T   L++ A        E  L++  +++  D +GRTAL ++ ++GH E V+ LI  
Sbjct: 538  DSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINP 597

Query: 1002 HADVNAADN-EKRSALQSAAWQGHVKVVQLLIE---HGAVVDHTCNQGATALCIAAQEGH 1057
             A +   DN  KR+ L ++   GH   ++LL+E   +   VD    +G T L +A   GH
Sbjct: 598  GASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGH 657

Query: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105
            ID V +LLE  A+ +  D  G TA+      GH + +++L +   S L
Sbjct: 658  IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 705



 Score =  288 bits (737), Expect = 3e-77
 Identities = 219/719 (30%), Positives = 331/719 (46%), Gaps = 108/719 (15%)

Query: 493  EQEVLQLLVKAGAHVNSEDDRTSCIVRQAL--EREDSIRTLLDNGASVNQCDSNGRTLLA 550
            + E+++LL+ +GA VN++D+     + +A+    E++++ L+ + A VN  D N +T L 
Sbjct: 28   DAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLH 87

Query: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
             AA + ++    +++   + + + D  G T L  AA  GH ++VN L+  GANIN  D+ 
Sbjct: 88   VAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKK 147

Query: 611  GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
               AL  AA+ GH +VV+ L+  G +V C D    T L AAA  G  ++V +LL  G E+
Sbjct: 148  DRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEI 207

Query: 671  NKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASV 730
            ++ +  G TAL  A Y G   +V  L+D+GA VN  + +G T L  AA    AS   A  
Sbjct: 208  DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAA----ASTHGALC 263

Query: 731  VSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAAS 790
            + LL++ GA+V+   KDG +PL + A  G       L++ G ++D  D +G TPL  AA 
Sbjct: 264  LELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAAR 323

Query: 791  MGHASVVNTLLFWGA---------------------------------AVDSIDSEGRTV 817
             GH  ++NTL   GA                                  +D+ D  GRT 
Sbjct: 324  YGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTC 383

Query: 818  LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
            L  A+A GNVE ++ L   G D + +D  G TPLH AA   H    E L+  GA  NE D
Sbjct: 384  LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443

Query: 878  NDGRIPF-------------ILASQEGHYD---------------CVQILLENKSNIDQR 909
            + GR                IL +   + +               C++ LL+N +N   R
Sbjct: 444  DWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIR 503

Query: 910  GYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT---LYILALENQLTMAEYFL 966
              +G N++  AA  GHR  +ELL     +   +++D   T   L++ A        E  L
Sbjct: 504  DKEGYNSIHYAAAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGHHQALEVLL 562

Query: 967  ENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADN-EKRSALQS------- 1018
            ++  +++  D +GRTAL ++ ++GH E V+ LI   A +   DN  KR+ L +       
Sbjct: 563  QSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHT 622

Query: 1019 -----------------------------AAWQGHVKVVQLLIEHGAVVDHTCNQGATAL 1049
                                         A   GH+  V LL+E  A VD     G TAL
Sbjct: 623  LCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTAL 682

Query: 1050 CIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGC 1108
                  GH + VQ+LLE        D  GRT +  AA  GH+  +  L +   S  + C
Sbjct: 683  HRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCC 741



 Score =  245 bits (625), Expect = 3e-64
 Identities = 213/743 (28%), Positives = 328/743 (44%), Gaps = 86/743 (11%)

Query: 441  TCQ-AKNLTPLEAQ------EFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKE 493
            TC+  K  TPL A           HL+N  ++++        ++  T +  +       +
Sbjct: 175  TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEIN-----VYGNTALHIACYN---GQ 226

Query: 494  QEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDS---IRTLLDNGASVNQCDSNGRTLLA 550
              V+  L+  GA+VN  ++     +  A         +  L++NGA VN    +G++ L 
Sbjct: 227  DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286

Query: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
              A  G       L+  G +++  D  G+TPL +AAR GH  ++N L   GA+       
Sbjct: 287  MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIH 346

Query: 611  GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
                L  AA   H++    LL +G ++D  D   RT L AAA GG+ + +  L   GA+ 
Sbjct: 347  SMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADF 406

Query: 671  NKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC-VPASK---G 726
            +K D  GRT L  AA   H   +E L+  GA VN  D  GRTAL  AA   +  +K   G
Sbjct: 407  HKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILG 466

Query: 727  HASVVSLLIDRGAEVDH-----C--------------DKDGMTPLLVAAYEGHVDVVDLL 767
            +A   S  ++R  E+       C              DK+G   +  AA  GH   ++LL
Sbjct: 467  NAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELL 526

Query: 768  LEGGADVDHTDNNGRT--PLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQG 825
            LE         ++G T  PL  AA  GH   +  LL     +D  D +GRT L +A+ +G
Sbjct: 527  LERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKG 586

Query: 826  NVEVVRTLLDRGLDENHRDDAGW-TPLHMAAFEGHRLICEALIEQGARTNEID---NDGR 881
            + E V  L++ G     +D+    TPLH +   GH L    L+E       +D     G+
Sbjct: 587  HTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646

Query: 882  IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
             P +LA   GH D V +LLE ++N+D     G  AL    + GH + V++L      + C
Sbjct: 647  TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706

Query: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEA---SDAEGRTALHVSCWQGHMEMVQVL 998
            KD+ GR  L+  A     T     L+   + E     D +G T LH +C+ G+   ++VL
Sbjct: 707  KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766

Query: 999  IAY---------------------HAD-------------VNAADNEKRSALQSAAWQGH 1024
            +                       H +             V+  D++ R+ L++AA+  H
Sbjct: 767  LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADH 826

Query: 1025 VKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG-ADPNHADQFGRTAMR 1083
            V+ +QLL+ H A V+   N G TAL +AA+ G    V +L+    AD    D+   T + 
Sbjct: 827  VECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLH 886

Query: 1084 VAAKNGHSQ-IIKLLEKYGASSL 1105
            +A   GH +  + +L+K    SL
Sbjct: 887  LACSKGHEKCALLILDKIQDESL 909



 Score =  214 bits (546), Expect = 4e-55
 Identities = 144/442 (32%), Positives = 225/442 (50%), Gaps = 6/442 (1%)

Query: 663  LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 722
            L+    +VN  D+E RT L  AA++G  EI+E L+  GA VN +D    T L  A     
Sbjct: 2    LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAV---- 57

Query: 723  ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
            AS+   +V  +LI   A+V+  DK+  TPL VAA    V   ++++   + V+ +D  GR
Sbjct: 58   ASRSEEAV-QVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGR 116

Query: 783  TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
            T L  AA  GH  +VN LL  GA +++ D + R  L  A+  G+++VV  L++ G +   
Sbjct: 117  TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176

Query: 843  RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
            +D  G+TPLH AA  G   + + L+  G   +EI+  G     +A   G    V  L++ 
Sbjct: 177  KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236

Query: 903  KSNIDQRGYDGRNALRVAALEGHRDI-VELLFSHGADVNCKDADGRPTLYILALENQLTM 961
             +N++Q   +G   L  AA   H  + +ELL ++GADVN +  DG+  L++ A+  + T 
Sbjct: 237  GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296

Query: 962  AEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAW 1021
            ++  ++NG  ++  D +G T LHV+   GH  ++  L    AD           L  AA 
Sbjct: 297  SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356

Query: 1022 QGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTA 1081
              H    + L+  G  +D     G T L  AA  G+++ +++L   GAD +  D+ GRT 
Sbjct: 357  NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416

Query: 1082 MRVAAKNGHSQIIKLLEKYGAS 1103
            +  AA N H   I+ L   GA+
Sbjct: 417  LHYAAANCHFHCIETLVTTGAN 438



 Score =  203 bits (516), Expect = 1e-51
 Identities = 179/544 (32%), Positives = 260/544 (47%), Gaps = 38/544 (6%)

Query: 495  EVLQLLVKAGAHVNSEDD--RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552
            E ++LL  +GA  + +D   RT      A      I TL+  GA+VN+ D  GRT L  A
Sbjct: 394  ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453

Query: 553  AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTK----VVNCLIGCGANINHTD 608
            A S         + R   + + +AH ++     AR+   K     +  L+   AN +  D
Sbjct: 454  AASD--------MDRNKTI-LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRD 504

Query: 609  QDGWTALRSAAWGGHTEVVSALLY---AGVKVDCADADSRTALRAAAWGGHEDIVLNLLQ 665
            ++G+ ++  AA  GH + +  LL    +G +   + A +++ L  AA+ GH   +  LLQ
Sbjct: 505  KEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA-TKSPLHLAAYNGHHQALEVLLQ 563

Query: 666  HGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED-VDGRTALSVAALCVPAS 724
               +++  D +GRTAL  AA+ GH E VE L++ GA +  +D V  RT L  + +     
Sbjct: 564  SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVI----- 618

Query: 725  KGHASVVSLLI---DRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG 781
             GH   + LL+   D    VD  D  G TPL++A   GH+D V LLLE  A+VD  D  G
Sbjct: 619  NGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG 678

Query: 782  RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841
             T L      GH   V  LL    ++   DS GRT L  A+A+G+   +  LL   L E 
Sbjct: 679  CTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEE 738

Query: 842  ---HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 898
                +D+ G+TPLH A + G+    E L+EQ      I N    P   A    H +C  +
Sbjct: 739  DCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP-FTPLHCAIINDHGNCASL 797

Query: 899  LLE--NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALE 956
            LL   + S +  R   GR  LR AA   H + ++LL  H A VN  D  G+ T  ++A E
Sbjct: 798  LLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK-TALMMAAE 856

Query: 957  NQLTMAEYFLENGANVE--ASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRS 1014
            N    A   L N A  +    D +  T LH++C +GH E   +LI       +  NEK +
Sbjct: 857  NGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGH-EKCALLILDKIQDESLINEKNN 915

Query: 1015 ALQS 1018
            ALQ+
Sbjct: 916  ALQT 919



 Score =  183 bits (464), Expect = 1e-45
 Identities = 119/362 (32%), Positives = 182/362 (50%), Gaps = 5/362 (1%)

Query: 766  LLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQG 825
            +L+    DV+  D+  RTPL  AA +G A ++  L+  GA V++ D+   T L  A A  
Sbjct: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 826  NVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFI 885
            + E V+ L+    D N RD    TPLH+AA        E +I   +  N  D  GR    
Sbjct: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 886  LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDAD 945
             A+  GH + V +LL   +NI+      R AL  AA  GH D+V LL +HGA+V CKD  
Sbjct: 121  HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180

Query: 946  GRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADV 1005
            G   L+  A   Q+ + ++ L  G  ++  +  G TALH++C+ G   +V  LI Y A+V
Sbjct: 181  GYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANV 240

Query: 1006 NAADNEKRSALQSAAWQGH-VKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
            N  +N   + L  AA   H    ++LL+ +GA V+     G + L + A  G     Q L
Sbjct: 241  NQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 300

Query: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSL 1124
            +++G + +  D+ G T + VAA+ GH  +I  L   GA +    +   +H+M    L +L
Sbjct: 301  IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADT----AKCGIHSMFPLHLAAL 356

Query: 1125 SS 1126
            ++
Sbjct: 357  NA 358


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  301 bits (770), Expect = 4e-81
 Identities = 188/571 (32%), Positives = 300/571 (52%), Gaps = 7/571 (1%)

Query: 533  DNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTK 592
            DN A V     +G T L  AA+ G+++V  LL++R A ++    +  TPL +A+++G+  
Sbjct: 225  DNNADVES--KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNAN 282

Query: 593  VVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAA 652
            +V  L+  GA I+   +DG T L   A  GH +VV  LL     +     +  + L  A 
Sbjct: 283  MVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMAT 342

Query: 653  WGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRT 712
             G H + V  LLQH   V+   N+  TAL  AA+ GH ++ + LLD  A  N + ++G T
Sbjct: 343  QGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT 402

Query: 713  ALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA 772
             L +A       K    V+ LL+  GA +    + G+TP+ VAA+ GHV++V  L+  GA
Sbjct: 403  PLHIAC-----KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457

Query: 773  DVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
              + T+  G T L  AA  G A VV  L+  GA V++   + +T L I++  G  ++V+ 
Sbjct: 458  SPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517

Query: 833  LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
            LL +G   N    +G+TPLH++A EGH  +   L++ GA  +     G  P  +A++ G 
Sbjct: 518  LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577

Query: 893  YDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYI 952
             +   +LL+  ++ D  G  G   L VAA   ++ +  LL   GA  +    +G   L+I
Sbjct: 578  LEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHI 637

Query: 953  LALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012
             A +NQ+ +A   LE GA+  A   +G  ++H++  +GH++MV +L+  +A+VN ++   
Sbjct: 638  AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697

Query: 1013 RSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN 1072
             + L  AA +  V V ++L+  GA VD     G T L +    G+I +V  LL+H A  N
Sbjct: 698  LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757

Query: 1073 HADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
               + G T +  AA+ GH+ II +L +  AS
Sbjct: 758  AKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788



 Score =  281 bits (719), Expect = 3e-75
 Identities = 190/567 (33%), Positives = 279/567 (49%), Gaps = 38/567 (6%)

Query: 531  LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGH 590
            LL+  A+V+    N  T L  A+  G+ ++V LL+ RGA ++ +   G TPL   AR GH
Sbjct: 254  LLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGH 313

Query: 591  TKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
             +VV  L+   A I    ++G + L  A  G H   V  LL   V VD    D  TAL  
Sbjct: 314  EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373

Query: 651  AAWGGHEDIV--------------LN-------------------LLQHGAEVNKADNEG 677
            AA  GH  +               LN                   LL+HGA +      G
Sbjct: 374  AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433

Query: 678  RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737
             T +  AA+MGH  IV  L+ HGA  N  +V G TAL +AA       G A VV  L+  
Sbjct: 434  LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA-----RSGQAEVVRYLVQD 488

Query: 738  GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797
            GA+V+   KD  TPL ++A  G  D+V  LL+ GA  +    +G TPL  +A  GH  V 
Sbjct: 489  GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVA 548

Query: 798  NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857
              LL  GA++     +G T L +A+  G +EV   LL +    +    +G TPLH+AA  
Sbjct: 549  AFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608

Query: 858  GHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNAL 917
             ++ +   L++QGA  +    +G  P  +A+++   D    LLE  ++ +     G  ++
Sbjct: 609  DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASV 668

Query: 918  RVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA 977
             +AA EGH D+V LL    A+VN  +  G   L++ A E+++ +AE  +  GA+V+A   
Sbjct: 669  HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTK 728

Query: 978  EGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAV 1037
             G T LHV C  G++++V  L+ + A VNA      + L  AA QGH  ++ +L+++ A 
Sbjct: 729  MGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788

Query: 1038 VDHTCNQGATALCIAAQEGHIDVVQVL 1064
             +     G TAL IA + G+I VV  L
Sbjct: 789  PNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  275 bits (704), Expect = 2e-73
 Identities = 189/586 (32%), Positives = 296/586 (50%), Gaps = 19/586 (3%)

Query: 532  LDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHT 591
            + NG  +N C+ NG   L  A+  G ++VV+ L+ R A+++     G+T L +A+  G  
Sbjct: 61   IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120

Query: 592  KVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
            +VV  L+  GAN+N   Q+G+T L  AA   H EVV  LL  G     A  D  T L  A
Sbjct: 121  EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180

Query: 652  AWGGHEDIVLNLLQHGAEVNKADNEGRT---ALIAAAYMGHREIVEHLLDHGAEVNHEDV 708
               GH+ +V  LL++       D +G+    AL  AA     +    LL +    + E  
Sbjct: 181  LQQGHDQVVSLLLEN-------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK 233

Query: 709  DGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL 768
             G T L +A     A  G+ +V +LL++R A VD   ++ +TPL VA+  G+ ++V LLL
Sbjct: 234  SGFTPLHIA-----AHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288

Query: 769  EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE 828
            + GA +D    +G TPL   A  GH  VV  LL   A + S    G + L +A+   ++ 
Sbjct: 289  DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348

Query: 829  VVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILAS 888
             V+ LL   +  +   +   T LH+AA  GH  + + L+++ A  N    +G  P  +A 
Sbjct: 349  CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408

Query: 889  QEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
            ++     +++LL++ ++I      G   + VAA  GH +IV  L  HGA  N  +  G  
Sbjct: 409  KKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468

Query: 949  TLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA 1008
             L++ A   Q  +  Y +++GA VEA   + +T LH+S   G  ++VQ L+   A  NAA
Sbjct: 469  ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA 528

Query: 1009 DNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1068
                 + L  +A +GH  V   L++HGA +  T  +G T L +AA+ G ++V  +LL+  
Sbjct: 529  TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588

Query: 1069 ADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS----SLNGCSP 1110
            A P+ A + G T + VAA   + ++  LL   GAS    + NG +P
Sbjct: 589  ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTP 634



 Score =  273 bits (698), Expect = 9e-73
 Identities = 176/561 (31%), Positives = 279/561 (49%), Gaps = 9/561 (1%)

Query: 543  SNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA 602
            S+       AA +G L+     +  G D+ I + +G   L LA+++GH +VV+ L+   A
Sbjct: 39   SDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREA 98

Query: 603  NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 662
            N++   + G TAL  A+  G  EVV  L+  G  V+    +  T L  AA   H ++V  
Sbjct: 99   NVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 158

Query: 663  LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 722
            LL +GA  + A  +G T L  A   GH ++V  LL++       D  G+  L   AL + 
Sbjct: 159  LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN-------DTKGKVRL--PALHIA 209

Query: 723  ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
            A K      +LL+      D   K G TPL +AA+ G+++V  LLL   A VD T  N  
Sbjct: 210  ARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI 269

Query: 783  TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
            TPL  A+  G+A++V  LL  GA +D+   +G T L   +  G+ +VV  LLDR      
Sbjct: 270  TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329

Query: 843  RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
            +   G +PLHMA    H    + L++     +++ ND      +A+  GHY   ++LL+ 
Sbjct: 330  KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389

Query: 903  KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
            K+N + +  +G   L +A  +    ++ELL  HGA +      G   +++ A    + + 
Sbjct: 390  KANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449

Query: 963  EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022
               + +GA+   ++  G TALH++   G  E+V+ L+   A V A   + ++ L  +A  
Sbjct: 450  SQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARL 509

Query: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAM 1082
            G   +VQ L++ GA  +     G T L ++A+EGH DV   LL+HGA  +   + G T +
Sbjct: 510  GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569

Query: 1083 RVAAKNGHSQIIKLLEKYGAS 1103
             VAAK G  ++  LL +  AS
Sbjct: 570  HVAAKYGKLEVANLLLQKSAS 590



 Score =  213 bits (541), Expect = 1e-54
 Identities = 138/460 (30%), Positives = 230/460 (50%), Gaps = 34/460 (7%)

Query: 672  KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731
            K  ++   + + AA  GH E     + +G ++N  + +G  AL +A     + +GH  VV
Sbjct: 36   KKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLA-----SKEGHVEVV 90

Query: 732  SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASM 791
            S L+ R A VD   K G T L +A+  G  +VV +L+  GA+V+    NG TPL  AA  
Sbjct: 91   SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150

Query: 792  GHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGL------------- 838
             H  VV  LL  GA+      +G T L++A  QG+ +VV  LL+                
Sbjct: 151  NHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAA 210

Query: 839  -------------DENHRD---DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
                         ++N+ D    +G+TPLH+AA  G+  +   L+ + A  +    +   
Sbjct: 211  RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT 270

Query: 883  PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
            P  +AS+ G+ + V++LL+  + ID +  DG   L   A  GH  +VE+L    A +  K
Sbjct: 271  PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSK 330

Query: 943  DADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYH 1002
              +G   L++    + L   +  L++   V+    +  TALHV+   GH ++ +VL+   
Sbjct: 331  TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKK 390

Query: 1003 ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQ 1062
            A+ NA      + L  A  +  +KV++LL++HGA +      G T + +AA  GH+++V 
Sbjct: 391  ANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS 450

Query: 1063 VLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
             L+ HGA PN  +  G TA+ +AA++G +++++ L + GA
Sbjct: 451  QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA 490



 Score =  184 bits (466), Expect = 7e-46
 Identities = 122/399 (30%), Positives = 188/399 (47%), Gaps = 31/399 (7%)

Query: 747  DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA 806
            D     L AA  GH++     ++ G D++  + NG   L  A+  GH  VV+ LL   A 
Sbjct: 40   DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99

Query: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
            VD+   +G T L IAS  G  EVV+ L+  G + N +   G+TPL+MAA E H  + + L
Sbjct: 100  VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159

Query: 867  IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE------------------------- 901
            ++ GA  +    DG  P  +A Q+GH   V +LLE                         
Sbjct: 160  LDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAA 219

Query: 902  ----NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
                N +N D     G   L +AA  G+ ++  LL +  A V+    +    L++ +   
Sbjct: 220  LLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRG 279

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
               M +  L+ GA ++A   +G T LH     GH ++V++L+   A + +      S L 
Sbjct: 280  NANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLH 339

Query: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
             A    H+  VQLL++H   VD   N   TAL +AA  GH  V +VLL+  A+PN     
Sbjct: 340  MATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN 399

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYGAS--SLNGCSPSPVH 1114
            G T + +A K    ++++LL K+GAS  ++     +P+H
Sbjct: 400  GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438



 Score =  105 bits (262), Expect = 3e-22
 Identities = 81/306 (26%), Positives = 141/306 (46%), Gaps = 66/306 (21%)

Query: 871  ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGH----- 925
            +R  +  +D    ++ A++ GH +     ++N  +I+    +G NAL +A+ EGH     
Sbjct: 32   SRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVS 91

Query: 926  ----------------------------RDIVELLFSHGADVNCKDADGRPTLYILALEN 957
                                         ++V++L ++GA+VN +  +G   LY+ A EN
Sbjct: 92   ELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQEN 151

Query: 958  QLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI-----------AYH---- 1002
             L + ++ L+NGA+   +  +G T L V+  QGH ++V +L+           A H    
Sbjct: 152  HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAAR 211

Query: 1003 -----------ADVNAADNEKRSA---LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048
                        + N AD E +S    L  AA  G++ V  LL+   A VD T     T 
Sbjct: 212  KDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITP 271

Query: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL--- 1105
            L +A++ G+ ++V++LL+ GA  +   + G T +   A++GH Q++++L    A  L   
Sbjct: 272  LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331

Query: 1106 -NGCSP 1110
             NG SP
Sbjct: 332  KNGLSP 337


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  292 bits (747), Expect = 2e-78
 Identities = 227/733 (30%), Positives = 341/733 (46%), Gaps = 94/733 (12%)

Query: 464  LQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALE 523
            L+L      +  I+NG P  D +  LI K+++V         +    + RT       L 
Sbjct: 4    LKLRDQPSLVQAIFNGDP--DEVRALIFKKEDV---------NFQDNEKRTPLHAAAYLG 52

Query: 524  REDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
              + I  L+ +GA VN  DS   T L  A  S S + V +L+   AD+   D +  TPL 
Sbjct: 53   DAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLH 112

Query: 584  LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
            +AA     K    L+   +N+N +D+ G TAL  AA+ GH E+V  LL  G  ++  D  
Sbjct: 113  IAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKK 172

Query: 644  SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEV 703
             R A+  AA+ GH ++V  L+ HGAEV   D +  T L AAA  G   +V++LLD G ++
Sbjct: 173  DRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232

Query: 704  NHEDVDGRTALSVAA----------------------------LCVPASKGHASV-VSLL 734
            N  +  G T L VA                             L   A+  H ++ + LL
Sbjct: 233  NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292

Query: 735  IDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHA 794
            +  GA+V+   KDG TPL + A  G       +++ GA +D  D NG TPL  AA  GH 
Sbjct: 293  VGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHE 352

Query: 795  SVVNTLLFWGA---------------------------------AVDSIDSEGRTVLSIA 821
             ++NTL+  GA                                  +D+ D  GRT L  A
Sbjct: 353  LLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAA 412

Query: 822  SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881
            +A GN+E +  LL+ G D N +D  G +PLH AA   +     AL+  GA  N++D  G 
Sbjct: 413  AAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGC 472

Query: 882  IPF-ILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH----- 935
             P    A+ +    C++ LL N +N   R   G NA+  +A  GHR  ++L+ S      
Sbjct: 473  TPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV 532

Query: 936  -----GADVNCKDADGRPT---LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSC 987
                 G D+   D+D R T   L++ A        E  +++  +++  ++ GRT L ++ 
Sbjct: 533  LMETSGTDM-LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAA 591

Query: 988  WQGHMEMVQVLIAYHADVNAADN-EKRSALQSAAWQGHVKVVQLLI---EHGAVVDHTCN 1043
            ++GH+E V VLI   A +   D   KR+ + +AA  GH + ++LLI   E    VD    
Sbjct: 592  FKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG 651

Query: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
             G T L ++   GH D V  LL  GA+ +  D++GRTA+   A  GH + +  L ++GA 
Sbjct: 652  NGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711

Query: 1104 SL--NGCSPSPVH 1114
             L  +    +P+H
Sbjct: 712  CLLRDSRGRTPIH 724



 Score =  258 bits (659), Expect = 3e-68
 Identities = 228/777 (29%), Positives = 351/777 (45%), Gaps = 79/777 (10%)

Query: 496  VLQLLVKAGAHVNSEDDRTSCIVRQALEREDS---IRTLLDNGASVNQCDSNGRTLLANA 552
            V+  L+  GA VN ++++    +  A         +  L+ NGA VN    +G+T L   
Sbjct: 254  VVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMT 313

Query: 553  AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
            A  G       ++  GA ++ ED +G+TPL +AAR GH  ++N LI  GA+       G 
Sbjct: 314  ALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGM 373

Query: 613  TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
              L  AA  G ++    LL +G  +D  D   RT L AAA GG+ + +  LL  GA+ NK
Sbjct: 374  FPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNK 433

Query: 673  ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
             D  GR+ L  AA   + + +  L+  GA VN  D  G T L  AA     S      + 
Sbjct: 434  KDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA----TSDTDGKCLE 489

Query: 733  LLIDRGAEVDHCDKDGMTPLLVAAYEGH---------VDVVDLLLE-GGADVDHTDNNGR 782
             L+   A     DK G   +  +A  GH            +D+L+E  G D+    +N  
Sbjct: 490  YLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRA 549

Query: 783  T--PLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840
            T  PL  AA  GH   +  L+     +D  +S GRT L +A+ +G+VE V  L+++G   
Sbjct: 550  TISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609

Query: 841  NHRDDA-GWTPLHMAAFEGHRLICEALIEQGARTNEID---NDGRIPFILASQEGHYDCV 896
              +D     TP+H AA  GH      LI      N +D    +G+ P +L+   GH DCV
Sbjct: 610  LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCV 669

Query: 897  QILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALE 956
              LL   +N+D +   GR AL   A+ GH + V+ L  HGA    +D+ GR  +++ A  
Sbjct: 670  YSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAAC 729

Query: 957  NQLTMAEYFLENGANVEA----SDAEGRTALHVSCWQGHMEMVQVLIAYH---------- 1002
              + +    L++ A+++A    +D  G TALH +C+ GH   V++L+             
Sbjct: 730  GHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF 789

Query: 1003 ------------------------ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038
                                    + VNA D++ R+ L +AA+  HV+ +QLL+ H A V
Sbjct: 790  SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849

Query: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEH-GADPNHADQFGRTAMRVAAKNGH-SQIIKL 1096
            +   + G T L +AA+ G  + V++L+    A+    D    TA+ +A   GH +  + +
Sbjct: 850  NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 909

Query: 1097 LEKYGASSL----NGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRG 1152
            LEK    +L    N    +P+H   +     L+  VQ L  K  S  +       P+L  
Sbjct: 910  LEKITDRNLINATNAALQTPLHVAAR---NGLTMVVQELLGKGASVLAVDENGYTPALAC 966

Query: 1153 LPN---GPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPI 1206
             PN       A    +  P S+     SSL+ N++    N     TS T + + +PI
Sbjct: 967  APNKDVADCLALILATMMPVSS-SSPLSSLTFNAINRYTN-----TSKTVSFEALPI 1017



 Score =  164 bits (414), Expect = 7e-40
 Identities = 137/464 (29%), Positives = 218/464 (46%), Gaps = 58/464 (12%)

Query: 489 LIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALE----REDSIRTLLDNGASVNQCDSN 544
           LI  E  +  L+  +G  + S+ D  + I    L        ++  L+ +   ++  +S+
Sbjct: 523 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582

Query: 545 GRTLLANAAYSGSLDVVNLLVSRGADL--------------------------------- 571
           GRT L  AA+ G ++ V++L+++GA +                                 
Sbjct: 583 GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEP 642

Query: 572 ----EIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVV 627
               +I+D +G TPL L+   GHT  V  L+  GAN++  D+ G TAL   A  GH E V
Sbjct: 643 QNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECV 702

Query: 628 SALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN----KADNEGRTALIA 683
            ALL  G K    D+  RT +  +A  GH  ++  LLQ  A ++     ADN G TAL  
Sbjct: 703 DALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHW 762

Query: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR-GAE-V 741
           A Y GH   VE LL+       +  +G     +    +  ++G A    +LID  GA  V
Sbjct: 763 ACYNGHETCVELLLEQEV---FQKTEGNAFSPLHCAVINDNEGAA---EMLIDTLGASIV 816

Query: 742 DHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL 801
           +  D  G TPL  AA+  HV+ + LLL   A V+  D+ G+TPL+ AA  G  + V  L+
Sbjct: 817 NATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV 876

Query: 802 FWGAAVDSI-DSEGRTVLSIASAQGNVEVVRTLLDRGLDE---NHRDDAGWTPLHMAAFE 857
              +A  ++ D+   T L +A ++G+      +L++  D    N  + A  TPLH+AA  
Sbjct: 877 SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936

Query: 858 GHRLICEALIEQGARTNEIDNDGRIPFI-LASQEGHYDCVQILL 900
           G  ++ + L+ +GA    +D +G  P +  A  +   DC+ ++L
Sbjct: 937 GLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score =  257 bits (656), Expect = 6e-68
 Identities = 196/614 (31%), Positives = 292/614 (47%), Gaps = 46/614 (7%)

Query: 603  NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 662
            N ++  Q    +L  A   G    V  LL  G  V+    +  + L  A   G+ ++   
Sbjct: 197  NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256

Query: 663  LLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721
            LL   A V    N+G  T L+AA+  G+ +IV+ LL H A+VN +   G TAL+ A    
Sbjct: 257  LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC--- 313

Query: 722  PASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-HTDNN 780
              + G   +V +L++ GA ++  +++G TPL+ AA  GHV+V  +LL+ GA ++ H++  
Sbjct: 314  --AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371

Query: 781  GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840
              + L  A   GH  +V  LL  GA  +    E  T L  A   G+VEV R LLD G   
Sbjct: 372  KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431

Query: 841  NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900
            N   D+  +PL +AA  GH  +   LIE+GA   E++++G  P + A++EGH + V +LL
Sbjct: 432  NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491

Query: 901  ENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQL 959
               +NI+ +  + +  AL +A   G  ++ + L   GAD+   +      L   + E  L
Sbjct: 492  AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHL 548

Query: 960  TMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019
             + +Y L +GANV A+ A G TAL  +C  GH ++  VL+   AD+       R+ L  A
Sbjct: 549  ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608

Query: 1020 AWQGHVKVVQLLIEHGAVVDH-TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFG 1078
            A  GH+  VQ LI  GA V+  T N   T + +A   GH+ VV++LL HGADP H  + G
Sbjct: 609  ARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDG 668

Query: 1079 RTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138
             T +  AAK GH+ ++  L  Y     N     P   + Q P  S               
Sbjct: 669  STMLIEAAKGGHTNVVSYLLDYP----NNVLSVPTTDVSQLPPPSQDQS----------- 713

Query: 1139 GSTGGGDMQPSLRGLPNGPTH--AFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTS 1196
                          +P  PTH  A   P + PD T      +L    L   K +S + +S
Sbjct: 714  -------------QVPRVPTHTLAMVVPPQEPDRTSQENSPAL----LGVQKGTSKQKSS 756

Query: 1197 STATAQTVPIDSFH 1210
            S   A    + SFH
Sbjct: 757  SLQVADQDLLPSFH 770



 Score =  231 bits (589), Expect = 4e-60
 Identities = 165/490 (33%), Positives = 245/490 (50%), Gaps = 12/490 (2%)

Query: 582  LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV-DCA 640
            L  A   G    V  L+  G ++N   ++G + L  A   G+ E+   LL     V D  
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
            +    T L AA+ GG+ DIV  LL H A+VN     G TAL  A   G  +IV+ LL+ G
Sbjct: 269  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEG 759
            A +   + +G T L  AA     S GH  V  +L+D GA ++ H ++   + L +A Y+G
Sbjct: 329  ANIEDHNENGHTPLMEAA-----SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 760  HVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819
            H+D+V  LLE GAD +H  +   T L+ A   GH  V   LL  GA V+       + L+
Sbjct: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 820  IASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN-EIDN 878
            +A+  G+VE+   L++RG +    +D G+TPL  AA EGH  +   L+ QGA  N + + 
Sbjct: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 879  DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938
                   LA   G  +    L++  ++I+         L  A+ EGH ++V+ L + GA+
Sbjct: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560

Query: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
            V+   A G   L          +A+  L+ GA++E     GRT L  +   GH+  VQ L
Sbjct: 561  VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL 620

Query: 999  IAYHADVN-AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 1057
            I+  A+VN A  N   + +  A   GH+ VV+LL+ HGA   H    G+T L  AA+ GH
Sbjct: 621  ISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 680

Query: 1058 IDVVQVLLEH 1067
             +VV  LL++
Sbjct: 681  TNVVSYLLDY 690



 Score =  226 bits (576), Expect = 1e-58
 Identities = 160/484 (33%), Positives = 244/484 (50%), Gaps = 12/484 (2%)

Query: 526  DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH-TPLTL 584
            +++R LLD G SVN+    G +LL  A  +G  ++  +L++  A++E     G  TPL  
Sbjct: 219  NAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA 278

Query: 585  AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
            A+  G+  +V  L+   A++N     G TAL  A  GG  ++V  LL  G  ++  + + 
Sbjct: 279  ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338

Query: 645  RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEV 703
             T L  AA  GH ++   LL HGA +N   NE + +AL  A Y GH ++V  LL+ GA+ 
Sbjct: 339  HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398

Query: 704  NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763
             H+  +  TAL  A +      GH  V  LL+D GA+V+       +PL +AA  GHV++
Sbjct: 399  EHKTDEMHTALMEACM-----DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 764  VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSIAS 822
              LL+E GA+++  ++ G TPL+ AA  GH  +V  LL  GA +++   E + T L++A 
Sbjct: 454  AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 823  AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
              G  EV   L+  G D    +    TPL  A+ EGH  + + L+  GA  +     G  
Sbjct: 514  CGGFSEVADFLIKAGAD---IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDT 570

Query: 883  PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
                A + GH D   +LL+  ++++     GR  L  AA  GH   V+ L S GA+VN  
Sbjct: 571  ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 630

Query: 943  DADGRPTLYILALE-NQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
             A+   T+  LA     L + E  L +GA+      +G T L  +   GH  +V  L+ Y
Sbjct: 631  TANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690

Query: 1002 HADV 1005
              +V
Sbjct: 691  PNNV 694



 Score =  209 bits (531), Expect = 2e-53
 Identities = 150/453 (33%), Positives = 226/453 (49%), Gaps = 18/453 (3%)

Query: 495 EVLQLLVKAGAHVNSED-----DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLL 549
           E+ Q+L+    H N ED     D T  +   +    D ++ LL + A VN   + G T L
Sbjct: 252 ELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309

Query: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-HTD 608
             A   G +D+V +L++ GA++E  + +GHTPL  AA  GH +V   L+  GA IN H++
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369

Query: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668
           +   +AL  A + GH ++V  LL AG   +    +  TAL  A   GH ++   LL  GA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429

Query: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
           +VN   +   + L  AA  GH E+   L++ GA +   + +G T L  A     A +GH 
Sbjct: 430 QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA-----AREGHE 484

Query: 729 SVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
            +V+LL+ +GA ++   ++   T L +A   G  +V D L++ GAD+   +    TPL+ 
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLME 541

Query: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
           A+  GH  +V  LL  GA V +  + G T L+ A   G+ +V   LL  G D  H  + G
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601

Query: 848 WTPLHMAAFEGHRLICEALIEQGARTNEID-NDGRIPFILASQEGHYDCVQILLENKSNI 906
            TPL  AA  GH    + LI +GA  N    N+      LA   GH   V++LL + ++ 
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661

Query: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
             R  DG   L  AA  GH ++V  L  +  +V
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score =  188 bits (477), Expect = 4e-47
 Identities = 120/334 (35%), Positives = 188/334 (56%), Gaps = 7/334 (2%)

Query: 707  DVDGRTALSV-AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD 765
            D+D  T  +   AL +  + GH  +VS+LI R A+++H DK G TPL++AA  GHV VV+
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 766  LLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ 824
            +LL+ G D++  ++    TPL  A S G   VV+ LL  GA  +  +    T LS+A++ 
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 825  GNVEVVRTLLDRGLDENHRDDA--GWTPLHMAAFEGHRLICEALIEQGARTN-EIDNDGR 881
            G V +++ LL+ G + N R  +  G +PL +AA  GH    + L++ G+  N +I+ +  
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 882  IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
                LA  +G  + V +LL+ K+N++ R   G   L  AA  G+ ++  +L   GADVN 
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285

Query: 942  KDA-DGRPT-LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
                  R T L I A +      E  +  GA+++  + +G T L ++   GH ++VQ+L+
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345

Query: 1000 AYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
               ADV+AADN K + L SA  +GHVKVVQ L++
Sbjct: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  174 bits (441), Expect = 5e-43
 Identities = 122/334 (36%), Positives = 181/334 (54%), Gaps = 11/334 (3%)

Query: 542  DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601
            +SN  T L  A   G  ++V++L++R A +E  D  G TPL LAA  GH  VV  L+  G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 602  ANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660
             +I   +++   T L  A  GG  EVV  LL  G   +  +    T L  AA GG+ +I+
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 661  LNLLQHGAEVNKADNE--GRTALIAAAYMGHREIVEHLLDHGAEVNHE-DVDGRTALSVA 717
              LL  GAE+N       G + L+ AA  GH   V+ LLD G+++N + + +  TAL++A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-- 775
                   +G A VVSLL+DR A V+H  K G+TPL+ AA  G+ +V  +LL+ GADV+  
Sbjct: 1232 CF-----QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286

Query: 776  HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLD 835
               ++  T L  AA  GH      L+  GA +D  + +G T L +AS  G+ +VV+ L+ 
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 836  RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
             G D +  D+   TPL  A  +GH  + + L+++
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  168 bits (426), Expect = 3e-41
 Identities = 117/336 (34%), Positives = 178/336 (52%), Gaps = 8/336 (2%)

Query: 570  DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSA 629
            D   E  H  T LTLA   GH ++V+ LI   A I H D+ G+T L  AA  GH  VV  
Sbjct: 1048 DAHTESNHD-TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106

Query: 630  LLYAGVKVDC-ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMG 688
            LL  G  ++  ++    T L  A  GG +++V  LL  GA     +    T L  AA  G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 689  HREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKD 747
            +  I++ LL+ GAE+N       + L ++ L + A  GH   V LL+D G++++   + +
Sbjct: 1167 YVNIIKILLNAGAEINSRT---GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223

Query: 748  GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807
              T L +A ++G  +VV LLL+  A+V+H    G TPL+ AAS G+A V   LL  GA V
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 808  DS--IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEA 865
            ++  + S   T L+IA+ +G+ +    L+ RG   + R+  G TPL +A+  GH  + + 
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 866  LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901
            L++ GA  +  DN    P + A ++GH   VQ L++
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  163 bits (413), Expect = 1e-39
 Identities = 112/314 (35%), Positives = 158/314 (50%), Gaps = 9/314 (2%)

Query: 494  QEVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVN-QCDSNGRTLLA 550
            +E++ +L+   A +   D +  T  I+         +  LLD G  +  Q +    T L+
Sbjct: 1068 EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLS 1127

Query: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
             A   G  +VV+LL++RGA+ E  +   +TPL+LAA  G+  ++  L+  GA IN     
Sbjct: 1128 LACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1187

Query: 611  --GWTALRSAAWGGHTEVVSALLYAGVKVDCA-DADSRTALRAAAWGGHEDIVLNLLQHG 667
              G + L  AA  GH   V  LL  G  ++   + +  TAL  A + G  ++V  LL   
Sbjct: 1188 KLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK 1247

Query: 668  AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
            A V      G T L+ AA  G+ E+   LLD GA+VN   V         AL + A KGH
Sbjct: 1248 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---TALTIAADKGH 1304

Query: 728  ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
                 LLI RGA +D  +K G TPL +A+  GH DVV LL++ GADVD  DN   TPL++
Sbjct: 1305 YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMS 1364

Query: 788  AASMGHASVVNTLL 801
            A   GH  VV  L+
Sbjct: 1365 AFRKGHVKVVQYLV 1378



 Score =  161 bits (407), Expect = 5e-39
 Identities = 113/334 (33%), Positives = 177/334 (52%), Gaps = 7/334 (2%)

Query: 773  DVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVR 831
            D+D HT++N  T L  A + GH  +V+ L+   A ++  D +G T L +A+  G+V VV 
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 832  TLLDRGLD-ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQE 890
             LLD+G D E   +    TPL +A   G + + + L+ +GA     +     P  LA+  
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 891  GHYDCVQILLENKSNIDQRGYD--GRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
            G+ + ++ILL   + I+ R     G + L +AA+ GH   V+LL   G+D+N +    R 
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 949  TLYILA-LENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA 1007
            T   LA  + +  +    L+  ANVE     G T L  +   G+ E+ +VL+   ADVNA
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285

Query: 1008 --ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL 1065
                + + +AL  AA +GH K  +LLI  GA +D    +G T L +A+  GH DVVQ+L+
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345

Query: 1066 EHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
            + GAD + AD    T +  A + GH ++++ L K
Sbjct: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  131 bits (330), Expect = 4e-30
 Identities = 89/298 (29%), Positives = 155/298 (52%), Gaps = 6/298 (2%)

Query: 811  DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
            +S   T L++A A G+ E+V  L+ R     HRD  G+TPL +AA  GH  + E L+++G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 871  ARTN-EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
                 + +     P  LA   G  + V +LL   +N + R       L +AA  G+ +I+
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 930  ELLFSHGADVNCKDAD--GRPTLYILALENQLTMAEYFLENGANVEASDAEGR-TALHVS 986
            ++L + GA++N +     G   L + A+   +   +  L+ G+++ A     R TAL ++
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 987  CWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH--TCNQ 1044
            C+QG  E+V +L+   A+V        + L  AA  G+ +V ++L++ GA V+     + 
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291

Query: 1045 GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
              TAL IAA +GH    ++L+  GA  +  ++ G T + +A+  GH  +++LL + GA
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 62/181 (34%), Positives = 94/181 (51%), Gaps = 8/181 (4%)

Query: 497  LQLLVKAGAHVNS--EDDRTSCIVRQALE-REDSIRTLLDNGASVNQCDSNGRTLLANAA 553
            ++LL+  G+ +N+  E +R + +     + R + +  LLD  A+V      G T L  AA
Sbjct: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265

Query: 554  YSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
              G  +V  +L+ +GAD+          T LT+AA +GH K    LI  GA+I+  ++ G
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKG 1325

Query: 612  WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
             T L  A+ GGH +VV  L+ AG  VD AD    T L +A   GH  +V  L++   EVN
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVN 1382

Query: 672  K 672
            +
Sbjct: 1383 Q 1383


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  257 bits (656), Expect = 6e-68
 Identities = 196/614 (31%), Positives = 292/614 (47%), Gaps = 46/614 (7%)

Query: 603  NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 662
            N ++  Q    +L  A   G    V  LL  G  V+    +  + L  A   G+ ++   
Sbjct: 197  NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256

Query: 663  LLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721
            LL   A V    N+G  T L+AA+  G+ +IV+ LL H A+VN +   G TAL+ A    
Sbjct: 257  LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC--- 313

Query: 722  PASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-HTDNN 780
              + G   +V +L++ GA ++  +++G TPL+ AA  GHV+V  +LL+ GA ++ H++  
Sbjct: 314  --AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371

Query: 781  GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840
              + L  A   GH  +V  LL  GA  +    E  T L  A   G+VEV R LLD G   
Sbjct: 372  KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431

Query: 841  NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900
            N   D+  +PL +AA  GH  +   LIE+GA   E++++G  P + A++EGH + V +LL
Sbjct: 432  NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491

Query: 901  ENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQL 959
               +NI+ +  + +  AL +A   G  ++ + L   GAD+   +      L   + E  L
Sbjct: 492  AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHL 548

Query: 960  TMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019
             + +Y L +GANV A+ A G TAL  +C  GH ++  VL+   AD+       R+ L  A
Sbjct: 549  ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608

Query: 1020 AWQGHVKVVQLLIEHGAVVDH-TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFG 1078
            A  GH+  VQ LI  GA V+  T N   T + +A   GH+ VV++LL HGADP H  + G
Sbjct: 609  ARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDG 668

Query: 1079 RTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSS 1138
             T +  AAK GH+ ++  L  Y     N     P   + Q P  S               
Sbjct: 669  STMLIEAAKGGHTNVVSYLLDYP----NNVLSVPTTDVSQLPPPSQDQS----------- 713

Query: 1139 GSTGGGDMQPSLRGLPNGPTH--AFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTS 1196
                          +P  PTH  A   P + PD T      +L    L   K +S + +S
Sbjct: 714  -------------QVPRVPTHTLAMVVPPQEPDRTSQENSPAL----LGVQKGTSKQKSS 756

Query: 1197 STATAQTVPIDSFH 1210
            S   A    + SFH
Sbjct: 757  SLQVADQDLLPSFH 770



 Score =  231 bits (589), Expect = 4e-60
 Identities = 165/490 (33%), Positives = 245/490 (50%), Gaps = 12/490 (2%)

Query: 582  LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV-DCA 640
            L  A   G    V  L+  G ++N   ++G + L  A   G+ E+   LL     V D  
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
            +    T L AA+ GG+ DIV  LL H A+VN     G TAL  A   G  +IV+ LL+ G
Sbjct: 269  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEG 759
            A +   + +G T L  AA     S GH  V  +L+D GA ++ H ++   + L +A Y+G
Sbjct: 329  ANIEDHNENGHTPLMEAA-----SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 760  HVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819
            H+D+V  LLE GAD +H  +   T L+ A   GH  V   LL  GA V+       + L+
Sbjct: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443

Query: 820  IASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN-EIDN 878
            +A+  G+VE+   L++RG +    +D G+TPL  AA EGH  +   L+ QGA  N + + 
Sbjct: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503

Query: 879  DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938
                   LA   G  +    L++  ++I+         L  A+ EGH ++V+ L + GA+
Sbjct: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560

Query: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
            V+   A G   L          +A+  L+ GA++E     GRT L  +   GH+  VQ L
Sbjct: 561  VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFL 620

Query: 999  IAYHADVN-AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 1057
            I+  A+VN A  N   + +  A   GH+ VV+LL+ HGA   H    G+T L  AA+ GH
Sbjct: 621  ISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 680

Query: 1058 IDVVQVLLEH 1067
             +VV  LL++
Sbjct: 681  TNVVSYLLDY 690



 Score =  226 bits (576), Expect = 1e-58
 Identities = 160/484 (33%), Positives = 244/484 (50%), Gaps = 12/484 (2%)

Query: 526  DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH-TPLTL 584
            +++R LLD G SVN+    G +LL  A  +G  ++  +L++  A++E     G  TPL  
Sbjct: 219  NAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA 278

Query: 585  AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
            A+  G+  +V  L+   A++N     G TAL  A  GG  ++V  LL  G  ++  + + 
Sbjct: 279  ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338

Query: 645  RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEV 703
             T L  AA  GH ++   LL HGA +N   NE + +AL  A Y GH ++V  LL+ GA+ 
Sbjct: 339  HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398

Query: 704  NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763
             H+  +  TAL  A +      GH  V  LL+D GA+V+       +PL +AA  GHV++
Sbjct: 399  EHKTDEMHTALMEACM-----DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 764  VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSIAS 822
              LL+E GA+++  ++ G TPL+ AA  GH  +V  LL  GA +++   E + T L++A 
Sbjct: 454  AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 823  AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
              G  EV   L+  G D    +    TPL  A+ EGH  + + L+  GA  +     G  
Sbjct: 514  CGGFSEVADFLIKAGAD---IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDT 570

Query: 883  PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
                A + GH D   +LL+  ++++     GR  L  AA  GH   V+ L S GA+VN  
Sbjct: 571  ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 630

Query: 943  DADGRPTLYILALE-NQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
             A+   T+  LA     L + E  L +GA+      +G T L  +   GH  +V  L+ Y
Sbjct: 631  TANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690

Query: 1002 HADV 1005
              +V
Sbjct: 691  PNNV 694



 Score =  209 bits (531), Expect = 2e-53
 Identities = 150/453 (33%), Positives = 226/453 (49%), Gaps = 18/453 (3%)

Query: 495 EVLQLLVKAGAHVNSED-----DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLL 549
           E+ Q+L+    H N ED     D T  +   +    D ++ LL + A VN   + G T L
Sbjct: 252 ELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309

Query: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-HTD 608
             A   G +D+V +L++ GA++E  + +GHTPL  AA  GH +V   L+  GA IN H++
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369

Query: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668
           +   +AL  A + GH ++V  LL AG   +    +  TAL  A   GH ++   LL  GA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429

Query: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
           +VN   +   + L  AA  GH E+   L++ GA +   + +G T L  A     A +GH 
Sbjct: 430 QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA-----AREGHE 484

Query: 729 SVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
            +V+LL+ +GA ++   ++   T L +A   G  +V D L++ GAD+   +    TPL+ 
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLME 541

Query: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
           A+  GH  +V  LL  GA V +  + G T L+ A   G+ +V   LL  G D  H  + G
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601

Query: 848 WTPLHMAAFEGHRLICEALIEQGARTNEID-NDGRIPFILASQEGHYDCVQILLENKSNI 906
            TPL  AA  GH    + LI +GA  N    N+      LA   GH   V++LL + ++ 
Sbjct: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661

Query: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
             R  DG   L  AA  GH ++V  L  +  +V
Sbjct: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694



 Score =  188 bits (477), Expect = 4e-47
 Identities = 120/334 (35%), Positives = 188/334 (56%), Gaps = 7/334 (2%)

Query: 707  DVDGRTALSV-AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD 765
            D+D  T  +   AL +  + GH  +VS+LI R A+++H DK G TPL++AA  GHV VV+
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 766  LLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ 824
            +LL+ G D++  ++    TPL  A S G   VV+ LL  GA  +  +    T LS+A++ 
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 825  GNVEVVRTLLDRGLDENHRDDA--GWTPLHMAAFEGHRLICEALIEQGARTN-EIDNDGR 881
            G V +++ LL+ G + N R  +  G +PL +AA  GH    + L++ G+  N +I+ +  
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 882  IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
                LA  +G  + V +LL+ K+N++ R   G   L  AA  G+ ++  +L   GADVN 
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285

Query: 942  KDA-DGRPT-LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
                  R T L I A +      E  +  GA+++  + +G T L ++   GH ++VQ+L+
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345

Query: 1000 AYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
               ADV+AADN K + L SA  +GHVKVVQ L++
Sbjct: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  174 bits (441), Expect = 5e-43
 Identities = 122/334 (36%), Positives = 181/334 (54%), Gaps = 11/334 (3%)

Query: 542  DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601
            +SN  T L  A   G  ++V++L++R A +E  D  G TPL LAA  GH  VV  L+  G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 602  ANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660
             +I   +++   T L  A  GG  EVV  LL  G   +  +    T L  AA GG+ +I+
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 661  LNLLQHGAEVNKADNE--GRTALIAAAYMGHREIVEHLLDHGAEVNHE-DVDGRTALSVA 717
              LL  GAE+N       G + L+ AA  GH   V+ LLD G+++N + + +  TAL++A
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-- 775
                   +G A VVSLL+DR A V+H  K G+TPL+ AA  G+ +V  +LL+ GADV+  
Sbjct: 1232 CF-----QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286

Query: 776  HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLD 835
               ++  T L  AA  GH      L+  GA +D  + +G T L +AS  G+ +VV+ L+ 
Sbjct: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

Query: 836  RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
             G D +  D+   TPL  A  +GH  + + L+++
Sbjct: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score =  168 bits (426), Expect = 3e-41
 Identities = 117/336 (34%), Positives = 178/336 (52%), Gaps = 8/336 (2%)

Query: 570  DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSA 629
            D   E  H  T LTLA   GH ++V+ LI   A I H D+ G+T L  AA  GH  VV  
Sbjct: 1048 DAHTESNHD-TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106

Query: 630  LLYAGVKVDC-ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMG 688
            LL  G  ++  ++    T L  A  GG +++V  LL  GA     +    T L  AA  G
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166

Query: 689  HREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKD 747
            +  I++ LL+ GAE+N       + L ++ L + A  GH   V LL+D G++++   + +
Sbjct: 1167 YVNIIKILLNAGAEINSRT---GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223

Query: 748  GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807
              T L +A ++G  +VV LLL+  A+V+H    G TPL+ AAS G+A V   LL  GA V
Sbjct: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 808  DS--IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEA 865
            ++  + S   T L+IA+ +G+ +    L+ RG   + R+  G TPL +A+  GH  + + 
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 866  LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901
            L++ GA  +  DN    P + A ++GH   VQ L++
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  163 bits (413), Expect = 1e-39
 Identities = 112/314 (35%), Positives = 158/314 (50%), Gaps = 9/314 (2%)

Query: 494  QEVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVN-QCDSNGRTLLA 550
            +E++ +L+   A +   D +  T  I+         +  LLD G  +  Q +    T L+
Sbjct: 1068 EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLS 1127

Query: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
             A   G  +VV+LL++RGA+ E  +   +TPL+LAA  G+  ++  L+  GA IN     
Sbjct: 1128 LACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1187

Query: 611  --GWTALRSAAWGGHTEVVSALLYAGVKVDCA-DADSRTALRAAAWGGHEDIVLNLLQHG 667
              G + L  AA  GH   V  LL  G  ++   + +  TAL  A + G  ++V  LL   
Sbjct: 1188 KLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK 1247

Query: 668  AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
            A V      G T L+ AA  G+ E+   LLD GA+VN   V         AL + A KGH
Sbjct: 1248 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---TALTIAADKGH 1304

Query: 728  ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
                 LLI RGA +D  +K G TPL +A+  GH DVV LL++ GADVD  DN   TPL++
Sbjct: 1305 YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMS 1364

Query: 788  AASMGHASVVNTLL 801
            A   GH  VV  L+
Sbjct: 1365 AFRKGHVKVVQYLV 1378



 Score =  161 bits (407), Expect = 5e-39
 Identities = 113/334 (33%), Positives = 177/334 (52%), Gaps = 7/334 (2%)

Query: 773  DVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVR 831
            D+D HT++N  T L  A + GH  +V+ L+   A ++  D +G T L +A+  G+V VV 
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105

Query: 832  TLLDRGLD-ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQE 890
             LLD+G D E   +    TPL +A   G + + + L+ +GA     +     P  LA+  
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165

Query: 891  GHYDCVQILLENKSNIDQRGYD--GRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
            G+ + ++ILL   + I+ R     G + L +AA+ GH   V+LL   G+D+N +    R 
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN 1225

Query: 949  TLYILA-LENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA 1007
            T   LA  + +  +    L+  ANVE     G T L  +   G+ E+ +VL+   ADVNA
Sbjct: 1226 TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285

Query: 1008 --ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL 1065
                + + +AL  AA +GH K  +LLI  GA +D    +G T L +A+  GH DVVQ+L+
Sbjct: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345

Query: 1066 EHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
            + GAD + AD    T +  A + GH ++++ L K
Sbjct: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  131 bits (330), Expect = 4e-30
 Identities = 89/298 (29%), Positives = 155/298 (52%), Gaps = 6/298 (2%)

Query: 811  DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
            +S   T L++A A G+ E+V  L+ R     HRD  G+TPL +AA  GH  + E L+++G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111

Query: 871  ARTN-EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
                 + +     P  LA   G  + V +LL   +N + R       L +AA  G+ +I+
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171

Query: 930  ELLFSHGADVNCKDAD--GRPTLYILALENQLTMAEYFLENGANVEASDAEGR-TALHVS 986
            ++L + GA++N +     G   L + A+   +   +  L+ G+++ A     R TAL ++
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231

Query: 987  CWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH--TCNQ 1044
            C+QG  E+V +L+   A+V        + L  AA  G+ +V ++L++ GA V+     + 
Sbjct: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291

Query: 1045 GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
              TAL IAA +GH    ++L+  GA  +  ++ G T + +A+  GH  +++LL + GA
Sbjct: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 62/181 (34%), Positives = 94/181 (51%), Gaps = 8/181 (4%)

Query: 497  LQLLVKAGAHVNS--EDDRTSCIVRQALE-REDSIRTLLDNGASVNQCDSNGRTLLANAA 553
            ++LL+  G+ +N+  E +R + +     + R + +  LLD  A+V      G T L  AA
Sbjct: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265

Query: 554  YSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
              G  +V  +L+ +GAD+          T LT+AA +GH K    LI  GA+I+  ++ G
Sbjct: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKG 1325

Query: 612  WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
             T L  A+ GGH +VV  L+ AG  VD AD    T L +A   GH  +V  L++   EVN
Sbjct: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVN 1382

Query: 672  K 672
            +
Sbjct: 1383 Q 1383


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
          Length = 2603

 Score =  255 bits (652), Expect = 2e-67
 Identities = 184/529 (34%), Positives = 267/529 (50%), Gaps = 21/529 (3%)

Query: 602  ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661
            AN   +D     +L  A   G    V  LL  G  V+    +  + L  A   G+ ++  
Sbjct: 228  ANAGQSDN---RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284

Query: 662  NLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720
             LL   A V     +G  T L+AAA  GH +IV+ LL H A+VN +   G TAL+ A   
Sbjct: 285  VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYAC-- 342

Query: 721  VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-HTDN 779
               + G+  VV +L++ GA ++  +++G TPL+ A   GHV+V  LLLE GA ++ H++ 
Sbjct: 343  ---AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399

Query: 780  NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
               + L  A   GH  +V  LL  GA  +    E  T L  A   G+VEV R LLD G  
Sbjct: 400  FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 459

Query: 840  ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
             N   D+  +PL +AA  GH  +   LIE+GA   E++++G  P + A++EGH + V +L
Sbjct: 460  VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519

Query: 900  LENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
            L   +NI+ +  + +  AL +A   G  ++ + L   GAD+   +      L   A E  
Sbjct: 520  LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGH 576

Query: 959  LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018
            L + +Y L  GANV A+ A G TAL  +C  GH ++  VL+   AD+       R+ L  
Sbjct: 577  LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636

Query: 1019 AAWQGHVKVVQLLIEHGAVVDHT-CNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
            AA  GHV  VQ LI  GA V+ T  N   T L +A   GH+ VV++LL HGADP H  + 
Sbjct: 637  AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPS------PVHTMEQKP 1120
            G T +  AAK GH+ ++  L  Y  + L+   P       P H + + P
Sbjct: 697  GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745



 Score =  230 bits (587), Expect = 6e-60
 Identities = 190/632 (30%), Positives = 292/632 (46%), Gaps = 58/632 (9%)

Query: 451  EAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA--HVN 508
            E + F L     +L+    E A  ++ +GT     L T+ P+ Q  L+ L++A     ++
Sbjct: 131  EVESFILD--QDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLS 188

Query: 509  SEDD----------RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSL 558
            + D           R +  V  AL+   +  T +   ++ N   S+ R+L A A   G +
Sbjct: 189  TADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSL-AEACSEGDV 247

Query: 559  DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
            + V  L+  G  +      G + L LA   G+ ++   L+   AN+              
Sbjct: 248  NAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR----------- 296

Query: 619  AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR 678
                           G+K D       T L AAA GGH  IV  LL H A+VN   + G 
Sbjct: 297  ---------------GIKGDI------TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335

Query: 679  TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRG 738
            TAL  A   G+ ++V+ LL+ GA +   + +G T L  A      S GH  V  LL++ G
Sbjct: 336  TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAG-----SAGHVEVARLLLENG 390

Query: 739  AEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797
            A ++ H ++   + L +A Y+GH+++V  LLE GAD +H  +   T L+ A   GH  V 
Sbjct: 391  AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 450

Query: 798  NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857
              LL  GA V+       + L++A+  G+VE+   L++RG      +D G+TPL  AA E
Sbjct: 451  RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAARE 510

Query: 858  GHRLICEALIEQGARTN-EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNA 916
            GH  +   L+ QGA  N + +        LA   G  +    L++  ++I+         
Sbjct: 511  GHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTP 567

Query: 917  LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD 976
            L  AA EGH ++V+ L + GA+V+   A G   L          +A+  L+ GA++E   
Sbjct: 568  LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627

Query: 977  AEGRTALHVSCWQGHMEMVQVLIAYHADVN-AADNEKRSALQSAAWQGHVKVVQLLIEHG 1035
              GRT L  +   GH+  VQ LI+  A+VN    N   + L  A   GH+ VV+LL+ HG
Sbjct: 628  EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687

Query: 1036 AVVDHTCNQGATALCIAAQEGHIDVVQVLLEH 1067
            A   H    G+T L  AA+ GH  VV  LL++
Sbjct: 688  ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719



 Score =  190 bits (483), Expect = 7e-48
 Identities = 118/334 (35%), Positives = 189/334 (56%), Gaps = 7/334 (2%)

Query: 707  DVDGRTALSV-AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVD 765
            D+D +T  +   AL +  + GH  +V  L++RGA ++H DK G TPL++AA  GHV VV+
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 766  LLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ 824
            +LL+ GAD++  ++    TPL  A S G   VV  LL  GA  +  +    T LS+A++ 
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 825  GNVEVVRTLLDRGLDENHRDDA--GWTPLHMAAFEGHRLICEALIEQGARTN-EIDNDGR 881
            G V +++ LL+ G + N R  +  G +PL +AA  GH    + L++ G+  N +I+ +  
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253

Query: 882  IPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
                LA  +G  + V +LL+ K+N++ R   G   L  AA  G+ ++  +L   GADVN 
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313

Query: 942  KDA-DGRPT-LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
                  R T L I A +      E  +  GA+++  + +G T L ++   GH+++VQ+L+
Sbjct: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373

Query: 1000 AYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
               ADV+AADN K + L +A  +GHVKVV+ L++
Sbjct: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  184 bits (466), Expect = 7e-46
 Identities = 122/355 (34%), Positives = 190/355 (53%), Gaps = 13/355 (3%)

Query: 631  LYAGVKVDC-ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGH 689
            +Y  + +D   +++  TAL  A  GGHE++V  LL+ GA +   D +G T LI AA  GH
Sbjct: 1069 IYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 1128

Query: 690  REIVEHLLDHGAEVNHEDVDGR-TALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG 748
              +VE LLD+GA++  +    + T LS+A      S G   VV LL+ RGA  +H +   
Sbjct: 1129 VGVVEILLDNGADIEAQSERTKDTPLSLA-----CSGGRQEVVELLLARGANKEHRNVSD 1183

Query: 749  MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN--GRTPLLAAASMGHASVVNTLLFWGAA 806
             TPL +AA  G+V+++ +LL  GA+++    +  G +PL+ AA  GH + V  LL  G+ 
Sbjct: 1184 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSD 1243

Query: 807  VDS-IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEA 865
            +++ I++   T L++A  QG  EVV  LLDR  +  HR   G TPL  AA  G+  +   
Sbjct: 1244 INAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1303

Query: 866  LIEQGARTN--EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923
            L+++GA  N   + +       +A+ +GHY   ++L+   ++ID R   G   L +AA  
Sbjct: 1304 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1363

Query: 924  GHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAE 978
            GH D+V+LL   GADV+  D      L     +  + +  Y ++   N   SD+E
Sbjct: 1364 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE-VNQFPSDSE 1417



 Score =  176 bits (445), Expect = 2e-43
 Identities = 119/314 (37%), Positives = 163/314 (51%), Gaps = 9/314 (2%)

Query: 494  QEVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVN-QCDSNGRTLLA 550
            +E++Q L++ GA +   D +  T  I+         +  LLDNGA +  Q +    T L+
Sbjct: 1096 EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLS 1155

Query: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
             A   G  +VV LL++RGA+ E  +   +TPL+LAA  G+  ++  L+  GA IN     
Sbjct: 1156 LACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1215

Query: 611  --GWTALRSAAWGGHTEVVSALLYAGVKVDCA-DADSRTALRAAAWGGHEDIVLNLLQHG 667
              G + L  AA  GHT  V  LL  G  ++   + +  TAL  A + G  ++V  LL   
Sbjct: 1216 KLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK 1275

Query: 668  AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
            A V      G T L+ AA  G+ E+   LLD GA+VN   V         AL + A KGH
Sbjct: 1276 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---TALTIAADKGH 1332

Query: 728  ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
                 LLI RGA +D  +K G TPL +AA  GH+DVV LL++ GADVD  DN   TPL+A
Sbjct: 1333 YKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMA 1392

Query: 788  AASMGHASVVNTLL 801
            A   GH  VV  L+
Sbjct: 1393 AFRKGHVKVVRYLV 1406



 Score =  175 bits (444), Expect = 2e-43
 Identities = 123/336 (36%), Positives = 180/336 (53%), Gaps = 11/336 (3%)

Query: 540  QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG 599
            Q +SN  T L  A   G  ++V  L+ RGA +E  D  G TPL LAA  GH  VV  L+ 
Sbjct: 1078 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137

Query: 600  CGANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658
             GA+I   +++   T L  A  GG  EVV  LL  G   +  +    T L  AA GG+ +
Sbjct: 1138 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 1197

Query: 659  IVLNLLQHGAEVNKADNE--GRTALIAAAYMGHREIVEHLLDHGAEVNHE-DVDGRTALS 715
            I+  LL  GAE+N       G + L+ AA  GH   V+ LLD G+++N + + +  TAL+
Sbjct: 1198 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1257

Query: 716  VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
            +A       +G   VVSLL+DR A V+H  K G+TPL+ AA  G+ +V  +LL+ GADV+
Sbjct: 1258 LACF-----QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312

Query: 776  --HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
                 ++  T L  AA  GH      L+  GA +D  + +G T L +A+  G+++VV+ L
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372

Query: 834  LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
            +  G D +  D+   TPL  A  +GH  +   L+++
Sbjct: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408



 Score =  167 bits (424), Expect = 5e-41
 Identities = 117/334 (35%), Positives = 178/334 (53%), Gaps = 7/334 (2%)

Query: 773  DVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVR 831
            D+D  T++N  T L  A + GH  +V TLL  GA+++  D +G T L +A+  G+V VV 
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 832  TLLDRGLD-ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQE 890
             LLD G D E   +    TPL +A   G + + E L+ +GA     +     P  LA+  
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 891  GHYDCVQILLENKSNIDQRGYD--GRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
            G+ + ++ILL   + I+ R     G + L +AA+ GH   V+LL   G+D+N +    R 
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253

Query: 949  TLYILA-LENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA 1007
            T   LA  + +  +    L+  ANVE     G T L  +   G+ E+ +VL+   ADVNA
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313

Query: 1008 --ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLL 1065
                + + +AL  AA +GH K  +LLI  GA +D    +G T L +AA  GH+DVVQ+L+
Sbjct: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373

Query: 1066 EHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
            + GAD + AD    T +  A + GH ++++ L K
Sbjct: 1374 QAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score =  159 bits (401), Expect = 2e-38
 Identities = 118/380 (31%), Positives = 182/380 (47%), Gaps = 9/380 (2%)

Query: 769  EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE 828
            E  A+   +DN     L  A S G  + V  LL  G +V+    EG ++L +A + G  E
Sbjct: 225  ESTANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYE 281

Query: 829  VVRTLLDRGLDENHRDDAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 887
            + + LL    +   R   G  TPL  AA  GH  I + L+   A  N   + G      A
Sbjct: 282  LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341

Query: 888  SQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGR 947
               G+ D V++LLE+ ++I+    +G   L  A   GH ++  LL  +GA +N    + +
Sbjct: 342  CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401

Query: 948  PTLYILAL-ENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
             +   LA  +  L M  + LE GA+ E    E  TAL  +C  GH+E+ ++L+   A VN
Sbjct: 402  ESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 461

Query: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
               +   S L  AA  GHV++  LLIE GA ++   ++G T L  AA+EGH ++V +LL 
Sbjct: 462  MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521

Query: 1067 HGADPN-HADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLS 1125
             GA+ N   ++   TA+ +A   G  ++   L K GA    GCS   +   ++  L+ + 
Sbjct: 522  QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581

Query: 1126 SKVQSLTIKSNSSGSTGGGD 1145
                 L   +N   +T  GD
Sbjct: 582  ---YLLAAGANVHATTATGD 598



 Score =  146 bits (369), Expect = 1e-34
 Identities = 92/318 (28%), Positives = 165/318 (51%), Gaps = 3/318 (0%)

Query: 788  AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
            + ++  A+   T +   +  ++  S+ R+ L+ A ++G+V  VR LL  G   N   + G
Sbjct: 209  SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267

Query: 848  WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI-PFILASQEGHYDCVQILLENKSNI 906
             + L +A   G+  + + L+   A   +    G I P + A+  GH   V++LL +K+++
Sbjct: 268  ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327

Query: 907  DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFL 966
            + +   G  AL  A   G+ D+V++L   GA +   + +G   L        + +A   L
Sbjct: 328  NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387

Query: 967  ENGANVEASDAEGR-TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025
            ENGA +     E + +AL ++C++GH+EMV+ L+   AD     +E  +AL  A   GHV
Sbjct: 388  ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447

Query: 1026 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
            +V +LL++ GA V+   +   + L +AA  GH+++  +L+E GA     +  G T +  A
Sbjct: 448  EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507

Query: 1086 AKNGHSQIIKLLEKYGAS 1103
            A+ GH +++ LL   GA+
Sbjct: 508  AREGHEEMVALLLGQGAN 525



 Score =  141 bits (356), Expect = 4e-33
 Identities = 94/298 (31%), Positives = 159/298 (53%), Gaps = 6/298 (2%)

Query: 811  DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
            +S   T L++A A G+ E+V+TLL+RG    HRD  G+TPL +AA  GH  + E L++ G
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139

Query: 871  ARTN-EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
            A    + +     P  LA   G  + V++LL   +N + R       L +AA  G+ +I+
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199

Query: 930  ELLFSHGADVNCKDAD--GRPTLYILALENQLTMAEYFLENGANVEASDAEGR-TALHVS 986
            ++L + GA++N +     G   L + A+       +  L+ G+++ A     R TAL ++
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA 1259

Query: 987  CWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH--TCNQ 1044
            C+QG  E+V +L+   A+V        + L  AA  G+ +V ++L++ GA V+     + 
Sbjct: 1260 CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1319

Query: 1045 GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
              TAL IAA +GH    ++L+  GA  +  ++ G T + +AA  GH  +++LL + GA
Sbjct: 1320 RDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1377



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 65/181 (35%), Positives = 95/181 (52%), Gaps = 8/181 (4%)

Query: 497  LQLLVKAGAHVNS--EDDRTSCIVRQALE-REDSIRTLLDNGASVNQCDSNGRTLLANAA 553
            ++LL+  G+ +N+  E +R + +     + R + +  LLD  A+V      G T L  AA
Sbjct: 1234 VKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAA 1293

Query: 554  YSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
              G  +V  +L+ +GAD+          T LT+AA +GH K    LIG GA+I+  ++ G
Sbjct: 1294 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKG 1353

Query: 612  WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
             T L  AA GGH +VV  L+ AG  VD AD    T L AA   GH  +V  L++   EVN
Sbjct: 1354 NTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK---EVN 1410

Query: 672  K 672
            +
Sbjct: 1411 Q 1411



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 39/113 (34%), Positives = 59/113 (52%), Gaps = 3/113 (2%)

Query: 495 EVLQLLVKAGAHVN--SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNG-RTLLAN 551
           +V  +L++AGA +   SE  RT  +         +++ L+  GA+VN+  +N   T+L+ 
Sbjct: 611 DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSL 670

Query: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANI 604
           A   G L VV LL++ GAD       G T L  AA+ GHT VV  L+    N+
Sbjct: 671 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNL 723



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 13/196 (6%)

Query: 1154 PNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLS 1213
            P  P  A +SP          Q SS S  +   S  SS  TT+S++ A TVP  S +   
Sbjct: 1931 PLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSS-ASTVPGTSTNGSP 1989

Query: 1214 FTEQIQQHS----LPRSRSRQSIVSPSST---TQSLGQSHNSPSSEFEWSQVKPSLKSTK 1266
             +  +++      +  S +  + V+ +++   T     ++  P+++  +    PS  S  
Sbjct: 1990 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP 2049

Query: 1267 ASKGGKSENS-AKSGSAGKKAKQSNSSQ----PKVLEYEMTQFDRRGPIAKSGTAAPPKQ 1321
            A  GG S NS    GSA      S+S Q    P V+E   T+       + S +A   +Q
Sbjct: 2050 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ 2109

Query: 1322 MPAESQCKIMIPSAQQ 1337
             P  S  +   P  QQ
Sbjct: 2110 QPPGSVSQEPRPPLQQ 2125


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  255 bits (652), Expect = 2e-67
 Identities = 184/529 (34%), Positives = 267/529 (50%), Gaps = 21/529 (3%)

Query: 602  ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661
            AN   +D     +L  A   G    V  LL  G  V+    +  + L  A   G+ ++  
Sbjct: 228  ANAGQSDN---RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQ 284

Query: 662  NLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALC 720
             LL   A V     +G  T L+AAA  GH +IV+ LL H A+VN +   G TAL+ A   
Sbjct: 285  VLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYAC-- 342

Query: 721  VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-HTDN 779
               + G+  VV +L++ GA ++  +++G TPL+ A   GHV+V  LLLE GA ++ H++ 
Sbjct: 343  ---AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNE 399

Query: 780  NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
               + L  A   GH  +V  LL  GA  +    E  T L  A   G+VEV R LLD G  
Sbjct: 400  FKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 459

Query: 840  ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
             N   D+  +PL +AA  GH  +   LIE+GA   E++++G  P + A++EGH + V +L
Sbjct: 460  VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALL 519

Query: 900  LENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
            L   +NI+ +  + +  AL +A   G  ++ + L   GAD+   +      L   A E  
Sbjct: 520  LGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI---ELGCSTPLMEAAQEGH 576

Query: 959  LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018
            L + +Y L  GANV A+ A G TAL  +C  GH ++  VL+   AD+       R+ L  
Sbjct: 577  LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636

Query: 1019 AAWQGHVKVVQLLIEHGAVVDHT-CNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF 1077
            AA  GHV  VQ LI  GA V+ T  N   T L +A   GH+ VV++LL HGADP H  + 
Sbjct: 637  AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696

Query: 1078 GRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPS------PVHTMEQKP 1120
            G T +  AAK GH+ ++  L  Y  + L+   P       P H + + P
Sbjct: 697  GSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAP 745



 Score =  244 bits (624), Expect = 3e-64
 Identities = 201/654 (30%), Positives = 312/654 (47%), Gaps = 54/654 (8%)

Query: 495  EVLQLLVKAGAHVNSEDDRTSCIVRQALER--EDSIRTLLDNGASVN-QCDSNGRTLLAN 551
            E+  LL++ GA +   +D     + +A     E+ +  LL  GA++N Q +    T L  
Sbjct: 481  ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540

Query: 552  AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
            A   G L+V + L+  GAD+E+  +   TPL  AA++GH ++V  L+  GAN++ T   G
Sbjct: 541  ACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATG 597

Query: 612  WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
             TAL  A   GHT+V   LL AG  ++      RT L  AA  GH   V  L+  GA VN
Sbjct: 598  DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVN 657

Query: 672  KAD-NEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASV 730
            +   N   T L  A   GH  +VE LL HGA+  H   DG T L  AA       GH SV
Sbjct: 658  RTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA-----KGGHTSV 712

Query: 731  VSLLIDRGAEVDHCDKDGMTPLLVAAYE----GHVDVVDL-LLEGGADVDHTDNNGRT-- 783
            V  L+D    +       +T L   +++      V V  L ++    + D    N  T  
Sbjct: 713  VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772

Query: 784  PLLAAASMGHASVVNT--------------------------LLFWGAAVD---SIDSEG 814
            P+   A  G AS ++                           +L    A+D     +S  
Sbjct: 773  PIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNH 832

Query: 815  RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
             T L++A A G+ E+V+TLL+RG    HRD  G+TPL +AA  GH  + E L++ GA   
Sbjct: 833  DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892

Query: 875  -EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933
             + +     P  LA   G  + V++LL   +N + R       L +AA  G+ +I+++L 
Sbjct: 893  AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 952

Query: 934  SHGADVNCKDAD--GRPTLYILALENQLTMAEYFLENGANVEASDAEGR-TALHVSCWQG 990
            + GA++N +     G   L + A+       +  L+ G+++ A     R TAL ++C+QG
Sbjct: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012

Query: 991  HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH--TCNQGATA 1048
              E+V +L+   A+V        + L  AA  G+ +V ++L++ GA V+     +   TA
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072

Query: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
            L IAA +GH    ++L+  GA  +  ++ G T + +AA  GH  +++LL + GA
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGA 1126



 Score =  230 bits (587), Expect = 6e-60
 Identities = 190/632 (30%), Positives = 292/632 (46%), Gaps = 58/632 (9%)

Query: 451  EAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA--HVN 508
            E + F L     +L+    E A  ++ +GT     L T+ P+ Q  L+ L++A     ++
Sbjct: 131  EVESFILD--QDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAAGIGKLS 188

Query: 509  SEDD----------RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSL 558
            + D           R +  V  AL+   +  T +   ++ N   S+ R+L A A   G +
Sbjct: 189  TADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSL-AEACSEGDV 247

Query: 559  DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
            + V  L+  G  +      G + L LA   G+ ++   L+   AN+              
Sbjct: 248  NAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR----------- 296

Query: 619  AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR 678
                           G+K D       T L AAA GGH  IV  LL H A+VN   + G 
Sbjct: 297  ---------------GIKGDI------TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGN 335

Query: 679  TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRG 738
            TAL  A   G+ ++V+ LL+ GA +   + +G T L  A      S GH  V  LL++ G
Sbjct: 336  TALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAG-----SAGHVEVARLLLENG 390

Query: 739  AEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVV 797
            A ++ H ++   + L +A Y+GH+++V  LLE GAD +H  +   T L+ A   GH  V 
Sbjct: 391  AGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 450

Query: 798  NTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857
              LL  GA V+       + L++A+  G+VE+   L++RG      +D G+TPL  AA E
Sbjct: 451  RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAARE 510

Query: 858  GHRLICEALIEQGARTN-EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNA 916
            GH  +   L+ QGA  N + +        LA   G  +    L++  ++I+         
Sbjct: 511  GHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTP 567

Query: 917  LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD 976
            L  AA EGH ++V+ L + GA+V+   A G   L          +A+  L+ GA++E   
Sbjct: 568  LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 627

Query: 977  AEGRTALHVSCWQGHMEMVQVLIAYHADVN-AADNEKRSALQSAAWQGHVKVVQLLIEHG 1035
              GRT L  +   GH+  VQ LI+  A+VN    N   + L  A   GH+ VV+LL+ HG
Sbjct: 628  EGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHG 687

Query: 1036 AVVDHTCNQGATALCIAAQEGHIDVVQVLLEH 1067
            A   H    G+T L  AA+ GH  VV  LL++
Sbjct: 688  ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719



 Score =  176 bits (445), Expect = 2e-43
 Identities = 119/314 (37%), Positives = 163/314 (51%), Gaps = 9/314 (2%)

Query: 494  QEVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVN-QCDSNGRTLLA 550
            +E++Q L++ GA +   D +  T  I+         +  LLDNGA +  Q +    T L+
Sbjct: 845  EELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLS 904

Query: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
             A   G  +VV LL++RGA+ E  +   +TPL+LAA  G+  ++  L+  GA IN     
Sbjct: 905  LACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 964

Query: 611  --GWTALRSAAWGGHTEVVSALLYAGVKVDCA-DADSRTALRAAAWGGHEDIVLNLLQHG 667
              G + L  AA  GHT  V  LL  G  ++   + +  TAL  A + G  ++V  LL   
Sbjct: 965  KLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRK 1024

Query: 668  AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
            A V      G T L+ AA  G+ E+   LLD GA+VN   V         AL + A KGH
Sbjct: 1025 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---TALTIAADKGH 1081

Query: 728  ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
                 LLI RGA +D  +K G TPL +AA  GH+DVV LL++ GADVD  DN   TPL+A
Sbjct: 1082 YKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMA 1141

Query: 788  AASMGHASVVNTLL 801
            A   GH  VV  L+
Sbjct: 1142 AFRKGHVKVVRYLV 1155



 Score =  175 bits (444), Expect = 2e-43
 Identities = 123/336 (36%), Positives = 180/336 (53%), Gaps = 11/336 (3%)

Query: 540  QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG 599
            Q +SN  T L  A   G  ++V  L+ RGA +E  D  G TPL LAA  GH  VV  L+ 
Sbjct: 827  QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886

Query: 600  CGANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED 658
             GA+I   +++   T L  A  GG  EVV  LL  G   +  +    T L  AA GG+ +
Sbjct: 887  NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 946

Query: 659  IVLNLLQHGAEVNKADNE--GRTALIAAAYMGHREIVEHLLDHGAEVNHE-DVDGRTALS 715
            I+  LL  GAE+N       G + L+ AA  GH   V+ LLD G+++N + + +  TAL+
Sbjct: 947  IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALT 1006

Query: 716  VAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
            +A       +G   VVSLL+DR A V+H  K G+TPL+ AA  G+ +V  +LL+ GADV+
Sbjct: 1007 LACF-----QGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061

Query: 776  H--TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833
                 ++  T L  AA  GH      L+  GA +D  + +G T L +A+  G+++VV+ L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121

Query: 834  LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
            +  G D +  D+   TPL  A  +GH  +   L+++
Sbjct: 1122 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157



 Score =  159 bits (401), Expect = 2e-38
 Identities = 118/380 (31%), Positives = 182/380 (47%), Gaps = 9/380 (2%)

Query: 769  EGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE 828
            E  A+   +DN     L  A S G  + V  LL  G +V+    EG ++L +A + G  E
Sbjct: 225  ESTANAGQSDNRS---LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYE 281

Query: 829  VVRTLLDRGLDENHRDDAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 887
            + + LL    +   R   G  TPL  AA  GH  I + L+   A  N   + G      A
Sbjct: 282  LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYA 341

Query: 888  SQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGR 947
               G+ D V++LLE+ ++I+    +G   L  A   GH ++  LL  +GA +N    + +
Sbjct: 342  CAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK 401

Query: 948  PTLYILAL-ENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
             +   LA  +  L M  + LE GA+ E    E  TAL  +C  GH+E+ ++L+   A VN
Sbjct: 402  ESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 461

Query: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
               +   S L  AA  GHV++  LLIE GA ++   ++G T L  AA+EGH ++V +LL 
Sbjct: 462  MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLG 521

Query: 1067 HGADPN-HADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLS 1125
             GA+ N   ++   TA+ +A   G  ++   L K GA    GCS   +   ++  L+ + 
Sbjct: 522  QGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVK 581

Query: 1126 SKVQSLTIKSNSSGSTGGGD 1145
                 L   +N   +T  GD
Sbjct: 582  ---YLLAAGANVHATTATGD 598



 Score =  146 bits (369), Expect = 1e-34
 Identities = 92/318 (28%), Positives = 165/318 (51%), Gaps = 3/318 (0%)

Query: 788  AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
            + ++  A+   T +   +  ++  S+ R+ L+ A ++G+V  VR LL  G   N   + G
Sbjct: 209  SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267

Query: 848  WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI-PFILASQEGHYDCVQILLENKSNI 906
             + L +A   G+  + + L+   A   +    G I P + A+  GH   V++LL +K+++
Sbjct: 268  ESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADV 327

Query: 907  DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFL 966
            + +   G  AL  A   G+ D+V++L   GA +   + +G   L        + +A   L
Sbjct: 328  NAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLL 387

Query: 967  ENGANVEASDAEGR-TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHV 1025
            ENGA +     E + +AL ++C++GH+EMV+ L+   AD     +E  +AL  A   GHV
Sbjct: 388  ENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 447

Query: 1026 KVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA 1085
            +V +LL++ GA V+   +   + L +AA  GH+++  +L+E GA     +  G T +  A
Sbjct: 448  EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEA 507

Query: 1086 AKNGHSQIIKLLEKYGAS 1103
            A+ GH +++ LL   GA+
Sbjct: 508  AREGHEEMVALLLGQGAN 525



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 13/196 (6%)

Query: 1154 PNGPTHAFSSPSESPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLS 1213
            P  P  A +SP          Q SS S  +   S  SS  TT+S++ A TVP  S +   
Sbjct: 1680 PLSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSS-ASTVPGTSTNGSP 1738

Query: 1214 FTEQIQQHS----LPRSRSRQSIVSPSST---TQSLGQSHNSPSSEFEWSQVKPSLKSTK 1266
             +  +++      +  S +  + V+ +++   T     ++  P+++  +    PS  S  
Sbjct: 1739 SSPSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPP 1798

Query: 1267 ASKGGKSENS-AKSGSAGKKAKQSNSSQ----PKVLEYEMTQFDRRGPIAKSGTAAPPKQ 1321
            A  GG S NS    GSA      S+S Q    P V+E   T+       + S +A   +Q
Sbjct: 1799 AQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAHSNQQ 1858

Query: 1322 MPAESQCKIMIPSAQQ 1337
             P  S  +   P  QQ
Sbjct: 1859 QPPGSVSQEPRPPLQQ 1874


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  243 bits (619), Expect = 1e-63
 Identities = 210/726 (28%), Positives = 317/726 (43%), Gaps = 119/726 (16%)

Query: 494  QEVLQLLV-KAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552
            +EV  LL  K   +V  ++ RT       +     ++ LL +GA+VN  D+   T L  A
Sbjct: 22   EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRA 81

Query: 553  AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
            A S +  V+ LL++  AD+   D    TPL +AA    TK    L    +++N  D+ G 
Sbjct: 82   AASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 141

Query: 613  TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
            +AL  A   GH E V+ LL  G  ++  D   R  L  AA+ GH +++  L+  GA++  
Sbjct: 142  SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGC 201

Query: 673  ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA------ALCV----- 721
             D +G   L  AA  G  E+V++LL  GAE++  +  G TAL +A      A+ +     
Sbjct: 202  KDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNA 261

Query: 722  ------PASKG----HASVVS--------LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763
                  P  KG    H + VS        LL++ GA+V++  K+G +PL +AA  G    
Sbjct: 262  GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTR 321

Query: 764  VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA------------------ 805
              +L++ G+++D  D  G TPL  AA  GH  +++TL+  GA                  
Sbjct: 322  SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVL 381

Query: 806  ---------------------------------AVDSIDSEGRTVLSIASAQGNVEVVRT 832
                                              +++ D+ GRT L  A++ GNVE +  
Sbjct: 382  FGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNL 441

Query: 833  LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
            LL  G D   RD  G TPLH AA  G       L+  GA  NE D  G  P   A+    
Sbjct: 442  LLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDT 501

Query: 893  YD----------------------------CVQILLENKSNIDQRGYDGRNALRVAALEG 924
            Y                             C++ LL+N ++   R   G  A+  AA  G
Sbjct: 502  YRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYG 561

Query: 925  HRDIVELLFSHGADVNC-KDADGR---PTLYILALENQLTMAEYFLENGANVEASDAEGR 980
            +R  +ELL       NC +D +       L++ A        +   E   N++  D +GR
Sbjct: 562  NRQNLELLLE--MSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR 619

Query: 981  TALHVSCWQGHMEMVQVLIAYHADVNAADNEKR-SALQSAAWQGHVKVVQLLIEHGA--- 1036
            TAL ++  +G  E V+VL A+ A     + +++ + L +AA  GH   + LLI+ G    
Sbjct: 620  TALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERAD 679

Query: 1037 VVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 1096
            + D     G T L +A   GH+D V +LLE G+  + AD  GRTA+   A  G    +  
Sbjct: 680  ITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAA 739

Query: 1097 LEKYGA 1102
            L  + A
Sbjct: 740  LLDHDA 745



 Score =  231 bits (589), Expect = 4e-60
 Identities = 209/747 (27%), Positives = 324/747 (43%), Gaps = 91/747 (12%)

Query: 500  LVKAGAHVNSEDDRTSCIVRQALEREDS---IRTLLDNGASVNQCDSNGRTLLANAAYSG 556
            LV AGA+VN  +D+    +  A    +    +  L++NGA VN     G++ L  AA  G
Sbjct: 258  LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317

Query: 557  SLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALR 616
                  +L+  G++++  D  G+TPL +AAR GH  +++ L+  GA+           L 
Sbjct: 318  RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLH 377

Query: 617  SAAWGGHTE-------------VVSAL-----LYAGVKVDCADADSRTALRAAAWGGHED 658
             A   G ++             +VS+L     L AG  ++  D   RT L AAA GG+ +
Sbjct: 378  LAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVE 437

Query: 659  IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAA 718
             +  LL  GA++ + D  GRT L  AA  G  +    L+  GA VN  D  G + L  AA
Sbjct: 438  CLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAA 497

Query: 719  LC---------VPAS--------------KGHASVVSLLIDRGAEVDHCDKDGMTPLLVA 755
                        P+S              K     +  L+D GA+    D+ G T +  A
Sbjct: 498  ASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYA 557

Query: 756  AYEGHVDVVDLLLEGGADV--DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 813
            A  G+   ++LLLE   +   D       +PL  AA  GH   + TL      +D  D +
Sbjct: 558  AAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHK 617

Query: 814  GRTVLSIASAQGNVEVVRTLLDRGLDENHRD-DAGWTPLHMAAFEGHRLICEALIEQGAR 872
            GRT L +A+ +G+ E V  L   G     ++    WTPLH AA  GH      LI+ G R
Sbjct: 618  GRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGER 677

Query: 873  ---TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929
               T+ +D  G+ P +LA   GH DCV +LLE  S  D     GR AL   A+ G  D +
Sbjct: 678  ADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCL 737

Query: 930  ELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDA----EGRTALHV 985
              L  H A V C+D  GR  +++ +      +    L+   + +  DA     G + +H 
Sbjct: 738  AALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHW 797

Query: 986  SCWQGHMEMVQVLIAYHAD----------------------------------VNAADNE 1011
            + + GH + +++L+ +                                     VN+ D +
Sbjct: 798  ASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAK 857

Query: 1012 KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG-AD 1070
             R+ L +AA+  +V  +++L++H A V+ T + G TAL  AA+ G    V+ LL  G AD
Sbjct: 858  GRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKAD 917

Query: 1071 PNHADQFGRTAMRVAAKNGHSQ--IIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKV 1128
                D+   TA+ +A   GH +  ++ L E      +N  + +    +       L+S V
Sbjct: 918  LTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVV 977

Query: 1129 QSLTIKSNSSGSTGGGDMQPSLRGLPN 1155
            Q+L     +  +       P+L   PN
Sbjct: 978  QALLSHGATVLAVDEEGHTPALACAPN 1004



 Score =  229 bits (585), Expect = 1e-59
 Identities = 206/681 (30%), Positives = 305/681 (44%), Gaps = 98/681 (14%)

Query: 526  DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
            +++  LL+ GAS+N CD   R  L  AA+ G L+V+ LLV+RGADL  +D  G+  L  A
Sbjct: 154  ETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTA 213

Query: 586  ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR 645
            A  G  +VV  L+  GA I+  +  G TAL  A + G   V   L+ AG  V+  +    
Sbjct: 214  AASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGF 273

Query: 646  TALRAAAWGGHEDIVLNLL-QHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVN 704
            T L  AA   +  + L LL  +GA+VN    EG++ L  AA  G     + L+ +G+E++
Sbjct: 274  TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID 333

Query: 705  HEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEV--------------------DHC 744
              D  G T L VAA       GH  ++S L+  GA+                     D C
Sbjct: 334  CADKFGNTPLHVAA-----RYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCC 388

Query: 745  -------------------------------DKDGMTPLLVAAYEGHVDVVDLLLEGGAD 773
                                           D  G T L  AA  G+V+ ++LLL  GAD
Sbjct: 389  RKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGAD 448

Query: 774  VDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVE----- 828
            +   D  GRTPL  AA+ G      TL+  GA V+  D +G + L  A+A          
Sbjct: 449  LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPH 508

Query: 829  -----------------------VVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEA 865
                                    +  LLD G D + RD  G+T +H AA  G+R   E 
Sbjct: 509  TPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLEL 568

Query: 866  LIEQGARTNEIDNDGRIPFI---LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAAL 922
            L+E      E D +  IP     LA+  GH + ++ L E   N+D R + GR AL +A  
Sbjct: 569  LLEMSFNCLE-DVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATE 627

Query: 923  EGHRDIVELLFSHGADVNCKDADGRPT-LYILALENQLTMAEYFLENGANVEASD---AE 978
             G  + VE+L +HGA    K+   + T L+  A           +++G   + +D   A 
Sbjct: 628  RGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAY 687

Query: 979  GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVV 1038
            G+T L ++   GH++ V +L+   +  +AAD   R+AL   A  G    +  L++H A V
Sbjct: 688  GQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV 747

Query: 1039 DHTCNQGATALCIAAQEGHIDVVQVLLEH--GADPNHA--DQFGRTAMRVAAKNGHSQII 1094
                 +G T + +A+  GH  V++ LL+     DP  A  D  G + M  A+  GH   +
Sbjct: 748  LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCL 807

Query: 1095 KLLEKYGA-SSLNGCSPSPVH 1114
            +LL ++   S L G   +P+H
Sbjct: 808  ELLLEHSPFSYLEGNPFTPLH 828



 Score =  220 bits (560), Expect = 9e-57
 Identities = 180/585 (30%), Positives = 267/585 (45%), Gaps = 56/585 (9%)

Query: 581  PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCA 640
            PL  A      + V  L+    NIN  DQ+  T L +AA+ G   ++  LL +G  V+  
Sbjct: 11   PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
            D    T L  AA   +E ++  LL H A+VN  D   +T L  AA     +  E L    
Sbjct: 71   DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLL 130

Query: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
            + +N  D  GR+AL  A        GH   V+LL+++GA ++ CDK    PL  AA+ GH
Sbjct: 131  SSLNVADRSGRSALHHA-----VHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH 185

Query: 761  VDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
            ++V+ LL+  GAD+   D  G   L  AA+ G   VV  LL  GA +D  ++ G T L I
Sbjct: 186  LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245

Query: 821  ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC-EALIEQGARTNEIDND 879
            A   G   V   L++ G + N  +D G+TPLH+AA   +  +C E L+  GA  N    +
Sbjct: 246  ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305

Query: 880  GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
            G+ P  +A+  G +   QIL++N S ID     G   L VAA  GH  ++  L ++GAD 
Sbjct: 306  GKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADT 365

Query: 940  NCKDADGRPTLYILAL------------ENQL------TMAEYFLENGANVEASDAEGRT 981
              +       L++  L              QL         E+ L  G ++   D  GRT
Sbjct: 366  ARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRT 425

Query: 982  ALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHT 1041
             LH +   G++E + +L++  AD+   D   R+ L  AA  G  +    L+  GA V+  
Sbjct: 426  CLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEA 485

Query: 1042 CNQGATALCIAA-------QEGHID---------------------VVQVLLEHGADPNH 1073
              +G + L  AA        E H                        ++ LL++GADP+ 
Sbjct: 486  DCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSL 545

Query: 1074 ADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSP----SPVH 1114
             D+ G TA+  AA  G+ Q ++LL +   + L         SP+H
Sbjct: 546  RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLH 590



 Score =  205 bits (522), Expect = 2e-52
 Identities = 184/612 (30%), Positives = 274/612 (44%), Gaps = 51/612 (8%)

Query: 500  LVKAGAHVNSEDD--RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGS 557
            ++ AG  +N+ D+  RT      +    + +  LL +GA + + D  GRT L  AA +GS
Sbjct: 409  VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468

Query: 558  LDVVNLLVSRGADLEIEDAHGHTPLTLAAR-------QGHTK------------------ 592
                  LV+ GA +   D  G +PL  AA        + HT                   
Sbjct: 469  YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKE 528

Query: 593  ---VVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV--DCADADSRTA 647
                +  L+  GA+ +  D+ G+TA+  AA  G+ + +  LL        D       + 
Sbjct: 529  AFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSP 588

Query: 648  LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
            L  AA+ GH + +  L +    ++  D++GRTAL  A   G  E VE L  HGA    ++
Sbjct: 589  LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648

Query: 708  VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD---KDGMTPLLVAAYEGHVDVV 764
               +     AA    A+ GH   + LLID G   D  D     G TPL++A   GHVD V
Sbjct: 649  RKRKWTPLHAA----AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704

Query: 765  DLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ 824
             LLLE G+  D  D  GRT L   A  G    +  LL   A V   D +GRT + +ASA 
Sbjct: 705  HLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASAC 764

Query: 825  GNVEVVRTLLDRGLDENHRDD----AGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
            G+  V+RTLL   L  +  D     +G++P+H A++ GH    E L+E  +  + ++ + 
Sbjct: 765  GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNP 823

Query: 881  RIPFILASQEGHYDCVQILLE--NKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938
              P   A         ++LL       ++ R   GR  L  AA   +   + +L  H A+
Sbjct: 824  FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE 883

Query: 939  VNCKDADGRPTLYILALENQLTMAEYFLENG-ANVEASDAEGRTALHVSCWQGHMEMVQV 997
            VN  D  GR  L   A   Q    E+ L  G A++   D    TALH++C +GH +   +
Sbjct: 884  VNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALM 943

Query: 998  LIAYHAD---VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT-ALCIAA 1053
            ++A   D   +NA ++  +  L  AA  G   VVQ L+ HGA V     +G T AL  A 
Sbjct: 944  ILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAP 1003

Query: 1054 QEGHIDVVQVLL 1065
             +   D + ++L
Sbjct: 1004 NKDVADCLALIL 1015



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 52/171 (30%), Positives = 78/171 (45%), Gaps = 4/171 (2%)

Query: 947  RPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
            +P L        +      L    N+   D E RT LH + + G + ++Q+L+   A+VN
Sbjct: 9    QPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVN 68

Query: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
            A D    + L  AA   + KV+ LL+ H A V+       T L +AA        + L  
Sbjct: 69   AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAP 128

Query: 1067 HGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSP---SPVH 1114
              +  N AD+ GR+A+  A  +GH + + LL   GA SLN C      P+H
Sbjct: 129  LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGA-SLNVCDKKERQPLH 178


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  214 bits (545), Expect = 5e-55
 Identities = 135/380 (35%), Positives = 198/380 (52%), Gaps = 5/380 (1%)

Query: 523 EREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPL 582
           E   +++ LL+    V++ +  G+T L  AA  G+L++V  L+  GA+  +ED    T L
Sbjct: 16  ENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75

Query: 583 TLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADA 642
             A+++GH  +V  L+ CG N+ H D  GWTAL  A + G T+VV  LL  G        
Sbjct: 76  ISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGL 135

Query: 643 DSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE 702
            S   +  AA  GH DIV  LLQ+GA+VN +D  G T L+ AA  GH E V+HLL  GA+
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762
           V+ E  +  TAL VA        G+   V  ++ R   V+  DKDG T L++A+ EGH +
Sbjct: 196 VDQEGANSMTALIVA-----VKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTE 250

Query: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822
           +V  LL+ G  V+  D +G T L+ A   GH  +V  LL   A +D    + +T L  A 
Sbjct: 251 IVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV 310

Query: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
            +GN  +VR +L    D       G TPL  A    +  + E L+++GA+ + +D  G  
Sbjct: 311 EKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDT 370

Query: 883 PFILASQEGHYDCVQILLEN 902
           P  +A +       ++LL N
Sbjct: 371 PLHIAIRGRSRKLAELLLRN 390



 Score =  192 bits (487), Expect = 3e-48
 Identities = 131/382 (34%), Positives = 191/382 (50%), Gaps = 5/382 (1%)

Query: 557 SLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALR 616
           ++  +  L+ +  D++  +  G TPL +AA QG+ ++V  LI  GAN N  D D WTAL 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 617 SAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNE 676
           SA+  GH  +V  LL  GV ++  D    TAL  A + G  D+V  LL HGA  +     
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 677 GRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLID 736
               +I AA  GH +IV  LL +GA+VN  D  G T L  AA      KGH   V  L+ 
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAA-----RKGHLECVKHLLA 191

Query: 737 RGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASV 796
            GA+VD    + MT L+VA   G+   V  +L+   +V+ TD +G T L+ A+  GH  +
Sbjct: 192 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEI 251

Query: 797 VNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAF 856
           V  LL  G  V+  D  G TVL  A   G+VE+VR LL +  D + R     T L+ A  
Sbjct: 252 VQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVE 311

Query: 857 EGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNA 916
           +G+  +   +++    T     DG  P I A++  + + V++LL+  + +      G   
Sbjct: 312 KGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTP 371

Query: 917 LRVAALEGHRDIVELLFSHGAD 938
           L +A     R + ELL  +  D
Sbjct: 372 LHIAIRGRSRKLAELLLRNPKD 393



 Score =  179 bits (455), Expect = 1e-44
 Identities = 131/390 (33%), Positives = 190/390 (48%), Gaps = 10/390 (2%)

Query: 495 EVLQLLVKAGAHVNSED-DRTSCIVRQALEREDSI-RTLLDNGASVNQCDSNGRTLLANA 552
           E+++ L+K GA+ N ED D  + ++  + E    I   LL  G ++   D  G T L  A
Sbjct: 52  EIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWA 111

Query: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
            Y G  DVV LL+S GA+  +   +   P+  AA +GH  +V+ L+  GA +N +D+ G 
Sbjct: 112 CYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGT 171

Query: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
           T L  AA  GH E V  LL  G  VD   A+S TAL  A  GG+   V  +L+    VN 
Sbjct: 172 TPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNL 231

Query: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
            D +G TAL+ A+  GH EIV+ LLD G  VN  D  G T L  A        GH  +V 
Sbjct: 232 TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGA-----VRGGHVEIVR 286

Query: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG 792
            L+ + A++D   +D  T L  A  +G+  +V  +L+   D +    +G TPL+ A  M 
Sbjct: 287 ALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMR 346

Query: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN---HRDDAGWT 849
           +  VV  LL  GA V ++D +G T L IA    + ++   LL    D       + AG T
Sbjct: 347 NIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGET 406

Query: 850 PLHMAAFEGHRLICEALIEQGARTNEIDND 879
           P ++       ++ +    +     E D D
Sbjct: 407 PYNIDCSHQKSILTQIFGARHLSPTETDGD 436



 Score =  174 bits (440), Expect = 7e-43
 Identities = 118/372 (31%), Positives = 189/372 (50%), Gaps = 5/372 (1%)

Query: 663  LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 722
            LL+   +V++ +  G+T L+ AA  G+ EIV+ L+ +GA  N ED+D  TAL  A+    
Sbjct: 24   LLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS---- 79

Query: 723  ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR 782
              +GH  +V  L+  G  ++H D  G T L+ A Y+G  DVV+LLL  GA+   T     
Sbjct: 80   -KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSV 138

Query: 783  TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
             P++ AA  GHA +V+ LL  GA V+  D  G T L  A+ +G++E V+ LL  G D + 
Sbjct: 139  YPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQ 198

Query: 843  RDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN 902
                  T L +A   G+    + ++++    N  D DG    ++AS+EGH + VQ LL+ 
Sbjct: 199  EGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258

Query: 903  KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
             + ++     G   L  A   GH +IV  L    AD++ +  D +  LY    +   TM 
Sbjct: 259  GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318

Query: 963  EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022
               L+   + E    +G T L  +    ++E+V++L+   A V+A D +  + L  A   
Sbjct: 319  RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRG 378

Query: 1023 GHVKVVQLLIEH 1034
               K+ +LL+ +
Sbjct: 379  RSRKLAELLLRN 390



 Score =  169 bits (429), Expect = 1e-41
 Identities = 115/384 (29%), Positives = 191/384 (49%), Gaps = 6/384 (1%)

Query: 758  EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTV 817
            E ++  +  LLE   DVD  +  G+TPL+ AA  G+  +V  L+  GA  +  D +  T 
Sbjct: 15   EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74

Query: 818  LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
            L  AS +G+V +V  LL  G++  HRD  GWT L  A ++G   + E L+  GA  +   
Sbjct: 75   LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134

Query: 878  NDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
                 P I A+  GH D V +LL+N + ++     G   L  AA +GH + V+ L + GA
Sbjct: 135  LYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGA 194

Query: 938  DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 997
            DV+ + A+    L +          +  L+   NV  +D +G TAL ++  +GH E+VQ 
Sbjct: 195  DVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQD 254

Query: 998  LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 1057
            L+     VN  D    + L  A   GHV++V+ L++  A +D       TAL  A ++G+
Sbjct: 255  LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314

Query: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHT 1115
              +V+ +L+   D     + G T +  A K  + ++++LL   GA  S+++    +P+H 
Sbjct: 315  ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374

Query: 1116 MEQKPLQSLSSKVQSLTIKSNSSG 1139
                 ++  S K+  L +++   G
Sbjct: 375  ----AIRGRSRKLAELLLRNPKDG 394



 Score =  115 bits (289), Expect = 2e-25
 Identities = 68/211 (32%), Positives = 120/211 (56%)

Query: 889  QEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
            +E +   ++ LLE   ++D+R   G+  L +AA +G+ +IV+ L  +GA+ N +D D   
Sbjct: 14   EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 949  TLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA 1008
             L   + E  + + E  L+ G N+E  D  G TAL  +C++G  ++V++L+++ A+ +  
Sbjct: 74   ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133

Query: 1009 DNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1068
                   +  AA +GH  +V LL+++GA V+ +   G T L  AA++GH++ V+ LL  G
Sbjct: 134  GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 1069 ADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
            AD +       TA+ VA K G++Q +K + K
Sbjct: 194  ADVDQEGANSMTALIVAVKGGYTQSVKEILK 224



 Score = 35.0 bits (79), Expect = 0.52
 Identities = 17/50 (34%), Positives = 32/50 (64%)

Query: 1054 QEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
            +E +I  ++ LLE   D +  ++ G+T + +AA+ G+ +I+K L K GA+
Sbjct: 14   EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGAN 63


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score =  213 bits (541), Expect = 1e-54
 Identities = 214/709 (30%), Positives = 304/709 (42%), Gaps = 136/709 (19%)

Query: 524  REDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
            R+D +  LL  GA+V+  D  G   L NA   G  +VV+LL+ +GAD    D   +TPL 
Sbjct: 228  RKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLH 287

Query: 584  LAARQGHTKVVNCLIGCGANINHTDQDGWTA--------------------LRSAAWGGH 623
             AA +G   V   L+  GA+ N  + DG +A                    L  AA  G+
Sbjct: 288  EAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGN 347

Query: 624  TEVVSALLYAGVKVDCADADSR--TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
             E + ALL   + V+C  +D R  T L  AA      IV  LLQHGA+V+  D  G   L
Sbjct: 348  EEKLMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406

Query: 682  IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE- 740
              A   GH E+ E LL HGA VN  D+   T L  A     ASK    V SLL+  GA+ 
Sbjct: 407  HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA-----ASKNRVEVCSLLLSHGADP 461

Query: 741  ----------VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD--------------- 775
                      VD      +   L   ++GH      LL+   + D               
Sbjct: 462  TLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQAAREADLAKVKKTLALEIINF 516

Query: 776  HTDNNGRTPLLAAASMGH---ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
                +  T L  A +  H     V   LL  GA V+  + +  T L +A+ + + +V+  
Sbjct: 517  KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576

Query: 833  LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
            L   G   N  D  G T LH AA  GH   C  L+  G+  + I   G      A+Q G+
Sbjct: 577  LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG----FTAAQMGN 632

Query: 893  YDCVQILLEN----KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
                QIL E+     S++D R       L  A+  G  + V+ L S   +VNC+D +GR 
Sbjct: 633  EAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCS-SQNVNCRDLEGRH 684

Query: 949  T--LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
            +  L+  A  N++++ EY L +GA+V A D  G   LH +C  GH E+ ++L+ + A VN
Sbjct: 685  STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744

Query: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT------------------- 1047
             AD  K + L  AA +G  ++ +LL++HGA        G T                   
Sbjct: 745  VADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGD 804

Query: 1048 -ALCIAAQEG----------------------------------HIDVVQVLLEHGADPN 1072
             AL  AA++G                                  +++V + LLEHGAD N
Sbjct: 805  AALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864

Query: 1073 HADQFGRTAMRVAAKNGHSQIIKLLEKYG--ASSLNGCSPSPVHTMEQK 1119
              D+ G   +  AA  GH  I  LL KY    ++ +  + +P+H   QK
Sbjct: 865  AQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQK 913



 Score =  209 bits (532), Expect = 2e-53
 Identities = 205/740 (27%), Positives = 315/740 (42%), Gaps = 97/740 (13%)

Query: 495  EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLL--- 549
            EV+ LL+  GA  N+ D+     + +A  +   D    LL +GA  N  +++G++ L   
Sbjct: 263  EVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322

Query: 550  -----------------ANAAYSGSLD-VVNLLVSRGADLEIEDAHGHTPLTLAARQGHT 591
                               AA SG+ + ++ LL     +    D    TPL LAA     
Sbjct: 323  DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRV 382

Query: 592  KVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
            ++V  L+  GA+++  D+ G   L +A   GH EV   LL  G  V+  D    T L  A
Sbjct: 383  RIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442

Query: 652  AWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH------LLDHGAEVNH 705
            A     ++   LL HGA+    +  G++A+  A     RE + +      LL    E + 
Sbjct: 443  ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502

Query: 706  EDVDGRTALSVAALCVPASKGHA-------------SVVSLLIDRGAEVDHCDKDGMTPL 752
              V    AL +     P S   A              V  LL+ +GA V+  +KD MTPL
Sbjct: 503  AKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562

Query: 753  LVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS 812
             VAA   H DV+++L + GA ++  D  G+T L  AA  GH      LL +G+    I  
Sbjct: 563  HVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL 622

Query: 813  EGRTVLSI--------------------------ASAQGNVEVVRTLLDRGLDENHRDDA 846
            +G T   +                          AS  G++E V+ L     + N RD  
Sbjct: 623  QGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLE 681

Query: 847  GW--TPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS 904
            G   TPLH AA      + E L+  GA  +  D  G +P   A   GHY+  ++L+ + +
Sbjct: 682  GRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGA 741

Query: 905  NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
            +++         L  AA +G  +I +LL  HGAD   K+ DG   L ++  E    + + 
Sbjct: 742  SVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK-EGDTDIQDL 800

Query: 965  FLENGA--------------------NVEASDAEGR--TALHVSCWQGHMEMVQVLIAYH 1002
               + A                    N+   D +GR  T LH++    ++E+ + L+ + 
Sbjct: 801  LRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG 860

Query: 1003 ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQ 1062
            ADVNA D      L +AA  GHV +  LLI++   V+ T     T L  AAQ+G   +  
Sbjct: 861  ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCA 920

Query: 1063 VLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQ 1122
            +LL HGADP   +Q G+T + +A  +    +  L++     +L  C   P  T+    L 
Sbjct: 921  LLLAHGADPTMKNQEGQTPLDLATADDIRAL--LIDAMPPEALPTCF-KPQATVVSASLI 977

Query: 1123 SLSSKVQSLTIKSNSSGSTG 1142
            S +S    L+  S+    TG
Sbjct: 978  SPASTPSCLSAASSIDNLTG 997



 Score =  197 bits (501), Expect = 6e-50
 Identities = 181/602 (30%), Positives = 268/602 (44%), Gaps = 61/602 (10%)

Query: 549  LANAAYSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINH 606
            L  A  +G +  V  LV   A++  +D  G   +PL  AA  G   VV  L+  GAN++ 
Sbjct: 186  LLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244

Query: 607  TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQH 666
             D  G   L +A   GH EVVS LL  G   +  D  + T L  AA  G  D+ + LLQH
Sbjct: 245  RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304

Query: 667  GAEVNKADNEGRTA--------------------LIAAAYMGHREIVEHLLDHGAEVNHE 706
            GA+ N  + +G++A                    L+ AA  G+ E +  LL     VN  
Sbjct: 305  GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNVNCH 363

Query: 707  DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDL 766
              DGR +     L + A      +V LL+  GA+V   DK G+ PL  A   GH +V +L
Sbjct: 364  ASDGRKS---TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 767  LLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI------ 820
            LL+ GA V+  D    TPL  AAS     V + LL  GA    ++  G++ + +      
Sbjct: 421  LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480

Query: 821  ---------------ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH---RLI 862
                           A+ + ++  V+  L   +    +  +  T LH A    H   + +
Sbjct: 481  RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQV 540

Query: 863  CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAAL 922
             E L+ +GA  NE + D   P  +A++  H D +++L ++ + ++     G+ AL  AAL
Sbjct: 541  TELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL 600

Query: 923  EGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982
             GH     LL S+G+D +     G       A +      +  L     +  SD + R  
Sbjct: 601  AGHLQTCRLLLSYGSDPSIISLQG-----FTAAQMGNEAVQQILSESTPIRTSDVDYR-- 653

Query: 983  LHVSCWQGHMEMVQVLIAYHADVNAADNEKR--SALQSAAWQGHVKVVQLLIEHGAVVDH 1040
            L  +   G +E V+ L +   +VN  D E R  + L  AA    V VV+ L+ HGA V  
Sbjct: 654  LLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712

Query: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
                G   L  A   GH +V ++L+ HGA  N AD +  T +  AA  G  +I KLL K+
Sbjct: 713  KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772

Query: 1101 GA 1102
            GA
Sbjct: 773  GA 774



 Score =  166 bits (419), Expect = 2e-40
 Identities = 163/550 (29%), Positives = 249/550 (45%), Gaps = 48/550 (8%)

Query: 386 QRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQAK 445
           + ++++ S LL  G   T +  H   A  +       ++ L    +GH +L  +      
Sbjct: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER-LTYEFKGHSLLQAAREADLA 503

Query: 446 NLTPLEAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
            +     +  AL +IN   Q ++ E AL           ++++L PK ++V +LL++ GA
Sbjct: 504 KVK----KTLALEIINFK-QPQSHETALHC---------AVASLHPKRKQVTELLLRKGA 549

Query: 506 HVNSEDDRTSCIVRQALER--EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
           +VN ++      +  A ER   D +  L  +GA +N  D+ G+T L  AA +G L    L
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609

Query: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
           L+S G+D  I    G T    AA+ G+ + V  ++     I  +D D    L  A+  G 
Sbjct: 610 LLSYGSDPSIISLQGFT----AAQMGN-EAVQQILSESTPIRTSDVD--YRLLEASKAGD 662

Query: 624 TEVVSALLYAGVKVDCADADSR--TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
            E V  L  +   V+C D + R  T L  AA      +V  LL HGA+V+  D  G   L
Sbjct: 663 LETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPL 721

Query: 682 IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEV 741
             A   GH E+ E L+ HGA VN  D+   T L  A     A+KG   +  LL+  GA+ 
Sbjct: 722 HNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA-----AAKGKYEICKLLLKHGADP 776

Query: 742 DHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL 801
              ++DG TPL +   EG  D+ DLL             G   LL AA  G  + V  L 
Sbjct: 777 TKKNRDGNTPLDLVK-EGDTDIQDLL------------RGDAALLDAAKKGCLARVQKLC 823

Query: 802 FWGAAVDSIDSEGR--TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH 859
                ++  D++GR  T L +A+   N+EV   LL+ G D N +D  G  PLH AA  GH
Sbjct: 824 -TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882

Query: 860 RLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRV 919
             I   LI+     N  D     P   A+Q+G      +LL + ++   +  +G+  L +
Sbjct: 883 VDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942

Query: 920 AALEGHRDIV 929
           A  +  R ++
Sbjct: 943 ATADDIRALL 952


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  211 bits (538), Expect = 3e-54
 Identities = 237/818 (28%), Positives = 339/818 (41%), Gaps = 158/818 (19%)

Query: 524  REDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
            R+D +  LL NGA+V   D  G   L NA   G  +VVNLL+  GAD    D   +TPL 
Sbjct: 70   RKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLH 129

Query: 584  LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA--------------------AWGGH 623
             AA +G   V   L+  GA     + DG TAL  A                    A  G+
Sbjct: 130  EAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGN 189

Query: 624  TEVVSALLYAGVKVDCADADSR--TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
             E + ALL   + V+C  +D R  T L  AA      IV  LLQHGA+V+  D      L
Sbjct: 190  EEKMMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPL 248

Query: 682  IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE- 740
              A   GH E+ E L+ HGA VN  D+   T L  A     ASK    V SLL+  GA+ 
Sbjct: 249  HNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA-----ASKNRVEVCSLLLSYGADP 303

Query: 741  ----------VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT------------- 777
                      +D      +   L   ++GH      LL+   + D T             
Sbjct: 304  TLLNCHNKSAIDLAPTPQLKERLAYEFKGH-----SLLQAAREADVTRIKKHLSLEMVNF 358

Query: 778  --DNNGRTPLLAAASMGH---ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
                   T L  AA+  +     +   LL  GA ++    E  T L +AS + + +VV  
Sbjct: 359  KHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEV 418

Query: 833  LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
            ++      N  D+ G T LH AA+ GH   C  L+  G   N I   G      A Q G+
Sbjct: 419  VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG----FTALQMGN 474

Query: 893  YDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPT--L 950
             +  Q+L E    I     +    L  AA  G  + V+ L +    VNC+D +GR +  L
Sbjct: 475  ENVQQLLQE---GISLGNSEADRQLLEAAKAGDVETVKKLCT-VQSVNCRDIEGRQSTPL 530

Query: 951  YILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADN 1010
            +  A  N++++ EY L++GA+V A D  G   LH +C  GH E+ ++L+ + A VN AD 
Sbjct: 531  HFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL 590

Query: 1011 EKRSALQSAAWQGHVKVVQLLIEHGA---------------VVDHTCN-----QGATALC 1050
             K + L  AA +G  ++ +LL++HGA               V D   +     +G  AL 
Sbjct: 591  WKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALL 650

Query: 1051 IAAQEG----------------------------------HIDVVQVLLEHGADPNHADQ 1076
             AA++G                                  +++V + LL+HGAD N  D+
Sbjct: 651  DAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDK 710

Query: 1077 FGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHTMEQK--------------- 1119
             G   +  AA  GH  +  LL KY A  ++ +  + +P+H   QK               
Sbjct: 711  GGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD 770

Query: 1120 ----------PLQSLSSKVQSLTIKSNSSGSTGGGDMQPS-LRGL--PNGPTHAFSSPSE 1166
                      PL  +S+   S  + +    S      +P  L G+  P     A SS   
Sbjct: 771  PTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPS 830

Query: 1167 SPDSTVDRQKSSLSNNSLKSSKNSSLRTTSSTATAQTV 1204
            SP S      SSL N S   S+ SS+ ++S T  A ++
Sbjct: 831  SPSSL--SAASSLDNLSGSFSELSSVVSSSGTEGASSL 866



 Score =  207 bits (528), Expect = 4e-53
 Identities = 212/797 (26%), Positives = 324/797 (40%), Gaps = 143/797 (17%)

Query: 494  QEVLQLLVKAGAHVNSEDDRTSCIVRQALE--REDSIRTLLDNGASVNQCDSNGRTLLAN 551
            ++V++ L++ GA+V + DD     +  A      + +  LL +GA  N  D+   T L  
Sbjct: 71   KDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHE 130

Query: 552  AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA--------------------ARQGHT 591
            AA  G +DV  +L+  GA+  I +  G T L LA                    AR G+ 
Sbjct: 131  AAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNE 190

Query: 592  -KVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRA 650
             K++  L     N + +D    T L  AA     ++V  LL  G  V   D      L  
Sbjct: 191  EKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250

Query: 651  AAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDG 710
            A   GH ++   L++HGA VN  D    T L  AA     E+   LL +GA+    +   
Sbjct: 251  ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310

Query: 711  RTALSVAAL------CVPASKGHA------------------------------------ 728
            ++A+ +A             KGH+                                    
Sbjct: 311  KSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHC 370

Query: 729  ----------SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTD 778
                       +  LL+ +GA ++   K+ +TPL VA+ + H DVV+++++  A V+  D
Sbjct: 371  AAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALD 430

Query: 779  NNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ-----------GNV 827
            N G+T L  AA  GH      LL +G   + I  +G T L + +             GN 
Sbjct: 431  NLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNS 490

Query: 828  EVVRTLLDRGL--------------DENHRDDAGW--TPLHMAAFEGHRLICEALIEQGA 871
            E  R LL+                   N RD  G   TPLH AA      + E L++ GA
Sbjct: 491  EADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGA 550

Query: 872  RTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL 931
              +  D  G +P   A   GHY+  ++L+++ + ++         L  AA +G  +I +L
Sbjct: 551  DVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKL 610

Query: 932  LFSHGADVNCKDADGRPTLYIL-------------------ALENQLTMAEYFLENGANV 972
            L  HGAD   K+ DG   L ++                   A +         L +  NV
Sbjct: 611  LLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNV 670

Query: 973  EASDAEGR--TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQL 1030
               D +GR  T LH++    ++E+ + L+ + ADVNA D      L +AA  GHV V  L
Sbjct: 671  NCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAAL 730

Query: 1031 LIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGH 1090
            LI++ A V+ T     T L  AAQ+G   +  +LL HGADP   +Q G+T + + + +  
Sbjct: 731  LIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDV 790

Query: 1091 SQII-------KLLEKYGASSLNGC-SP------------SPVHTMEQKPLQSLSSKVQS 1130
            S ++        L   Y    LNG  SP            SP        L +LS     
Sbjct: 791  SALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSE 850

Query: 1131 LTIKSNSSGSTGGGDMQ 1147
            L+   +SSG+ G   ++
Sbjct: 851  LSSVVSSSGTEGASSLE 867



 Score =  196 bits (499), Expect = 1e-49
 Identities = 186/624 (29%), Positives = 278/624 (44%), Gaps = 83/624 (13%)

Query: 549  LANAAYSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINH 606
            L  A  +G ++ V  LV+    +   D  G   TPL  AA  G   VV  L+  GAN+  
Sbjct: 28   LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86

Query: 607  TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQH 666
             D  G   L +A   GH EVV+ LL  G   +  D  + T L  AA  G  D+ + LLQH
Sbjct: 87   RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146

Query: 667  GAEVNKADNEGRTA--------------------LIAAAYMGHREIVEHLLDHGAEVNHE 706
            GAE    + +GRTA                    L+ +A  G+ E +  LL     VN  
Sbjct: 147  GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNVNCH 205

Query: 707  DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDL 766
              DGR +     L + A      +V LL+  GA+V   DK  + PL  A   GH +V +L
Sbjct: 206  ASDGRKS---TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262

Query: 767  LLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA-----------AVD------- 808
            L++ GA V+  D    TPL  AAS     V + LL +GA           A+D       
Sbjct: 263  LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322

Query: 809  ----SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAA---FEGHRL 861
                + + +G ++L  A+ + +V  ++  L   +          T LH AA   +   + 
Sbjct: 323  KERLAYEFKGHSLLQ-AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381

Query: 862  ICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAA 921
            ICE L+ +GA  NE   +   P  +AS++ H D V++++++++ ++     G+ +L  AA
Sbjct: 382  ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441

Query: 922  LEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN--QLTMAEYFLENG---------- 969
              GH     LL S+G D N     G   L  +  EN  QL      L N           
Sbjct: 442  YCGHLQTCRLLLSYGCDPNIISLQGFTALQ-MGNENVQQLLQEGISLGNSEADRQLLEAA 500

Query: 970  --------------ANVEASDAEGR--TALHVSCWQGHMEMVQVLIAYHADVNAADNEKR 1013
                           +V   D EGR  T LH +     + +V+ L+ + ADV+A D    
Sbjct: 501  KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560

Query: 1014 SALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNH 1073
              L +A   GH +V +LL++HGAVV+       T L  AA +G  ++ ++LL+HGADP  
Sbjct: 561  VPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTK 620

Query: 1074 ADQFGRTAMRVAAKNGHSQIIKLL 1097
             ++ G T + +  K+G + I  LL
Sbjct: 621  KNRDGNTPLDL-VKDGDTDIQDLL 643



 Score =  135 bits (341), Expect = 2e-31
 Identities = 123/437 (28%), Positives = 192/437 (43%), Gaps = 51/437 (11%)

Query: 750  TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
            TPL  AA  G  DVV+ LL+ GA+V   D+ G  PL  A S GHA VVN LL  GA  ++
Sbjct: 60   TPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNA 119

Query: 810  IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC-----E 864
             D+   T L  A+ +G ++V   LL  G +   R+  G T L +A      ++      +
Sbjct: 120  RDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKD 179

Query: 865  ALIEQGARTNEID--------------NDGR--IPFILASQEGHYDCVQILLENKSNIDQ 908
             L+E     NE                +DGR   P  LA+       VQ+LL++ +++  
Sbjct: 180  ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239

Query: 909  RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLEN 968
            +       L  A   GH ++ ELL  HGA VN  D      L+  A +N++ +    L  
Sbjct: 240  KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299

Query: 969  GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA-------------------- 1008
            GA+    +   ++A+ ++      E +      H+ + AA                    
Sbjct: 300  GADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFK 359

Query: 1009 -DNEKRSALQSAAWQGHVKVVQL---LIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
                  +AL  AA   + K  Q+   L+  GA ++    +  T L +A+++ H DVV+V+
Sbjct: 360  HPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVV 419

Query: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSL 1124
            ++H A  N  D  G+T++  AA  GH Q  +LL  Y      GC P+ +       LQ  
Sbjct: 420  VKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSY------GCDPNIISLQGFTALQMG 473

Query: 1125 SSKVQSLTIKSNSSGST 1141
            +  VQ L  +  S G++
Sbjct: 474  NENVQQLLQEGISLGNS 490



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 68/239 (28%), Positives = 105/239 (43%), Gaps = 58/239 (24%)

Query: 939  VNCKDADGRPT--LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996
            VN +D  GR +  L+  A   +  + EY L+NGANV+A D  G   LH +C  GH E+V 
Sbjct: 49   VNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVN 108

Query: 997  VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA---- 1052
            +L+ + AD NA DN   + L  AA +G + V  +L++HGA        G TAL +A    
Sbjct: 109  LLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSA 168

Query: 1053 -------------------------------------AQEG-------------HIDVVQ 1062
                                                 A +G              + +VQ
Sbjct: 169  KAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQ 228

Query: 1063 VLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHTMEQK 1119
            +LL+HGAD +  D+     +  A   GH ++ +LL K+GA  ++++    +P+H    K
Sbjct: 229  LLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASK 287


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  207 bits (527), Expect = 6e-53
 Identities = 186/651 (28%), Positives = 291/651 (44%), Gaps = 41/651 (6%)

Query: 529  RTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQ 588
            R ++ N A  ++ D  GRT L     +  LD  + L+  GAD+   D    T L LAA++
Sbjct: 32   RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91

Query: 589  GHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL--YAGVKVDCADADSRT 646
            G+ + +  L+   AN    D +  T L         + ++ LL   A  +VD  D + +T
Sbjct: 92   GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151

Query: 647  ALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHRE-----IVEHLLDHGA 701
            AL  +A+  + + V  L++H + +   D EG+  L  AA   H++      V  +LD   
Sbjct: 152  ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAP 209

Query: 702  E---VNHEDVDGRTALSVAALCVPASKGHASVVSLLID-RGAEVDHCDKDGMTPLLVAAY 757
                +N +D +GRT L  A      + G+ +VV +L       +   D    TPL  AA 
Sbjct: 210  TESLLNWQDYEGRTPLHFAV-----ADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL 264

Query: 758  EGHVDVVDLLLEGG-ADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRT 816
             GH  +V LLLE   +    +D+ G TPL  AA    A  V   L   +  D  D EGRT
Sbjct: 265  LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324

Query: 817  VLSIASAQGNVEVVRTLLD--RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
                A+ +G+ +V+RT+L     +D N  D  G T LH AA  GH    + L+E  A+ +
Sbjct: 325  SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVD 384

Query: 875  EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934
              D     P   A + GH D +Q L++  + +D    DG + L  AAL G+ D+ ++L  
Sbjct: 385  ATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444

Query: 935  HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994
            +  + N +D  GR  L   A    +      +EN A+    D EGRTALH SC  G+++ 
Sbjct: 445  NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDA 504

Query: 995  VQVLIAYHADVNAADN--EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA 1052
            +++L+ + A  N  +N  E+ + L  A      +V+Q ++EHGA+        A     A
Sbjct: 505  IKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQA 564

Query: 1053 AQEGH------IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY-GASSL 1105
              +G+       D   +L++H       +Q  + A   A K       K  E+  G  S 
Sbjct: 565  VYKGYKVRKAFRDRKNLLMKH-------EQLRKDA--AAKKREEENKRKEAEQQKGRRSP 615

Query: 1106 NGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNG 1156
            + C P  +  +     Q + S+      K   +G+   G      RG P G
Sbjct: 616  DSCRPQALPCLPS--TQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRGSPGG 664



 Score =  114 bits (286), Expect = 5e-25
 Identities = 79/251 (31%), Positives = 126/251 (50%), Gaps = 9/251 (3%)

Query: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIE--DAHGHTPLT 583
           ++++  L + +  +  D  GRT    AA  GS DV+  ++S  +D++I   D +G T L 
Sbjct: 303 ETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALH 362

Query: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
            AA  GH   V  L+   A ++ TD    T L  A   GH +V+  L+  G +VD  D D
Sbjct: 363 AAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422

Query: 644 SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEV 703
             + L  AA GG+ D+   L+++    N  D  GRT L  AAY G+   +  L+++ A+ 
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD--KDGMTPLLVAAYEGHV 761
           N +D +GRTAL  +      + G+   + LL+D  A  +  +  ++  TPL  A      
Sbjct: 483 NIQDKEGRTALHWS-----CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH 537

Query: 762 DVVDLLLEGGA 772
           +V+  +LE GA
Sbjct: 538 EVIQFMLEHGA 548



 Score =  112 bits (279), Expect = 3e-24
 Identities = 83/264 (31%), Positives = 129/264 (48%), Gaps = 14/264 (5%)

Query: 506 HVNSEDD-----RTSCIVRQALEREDSIRTLLD--NGASVNQCDSNGRTLLANAAYSGSL 558
           H + +DD     RTS +       +D +RT+L   +   +N  D  G T L  AA SG +
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370

Query: 559 DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
             V LL+   A ++  D   HTPL  A   GH  V+  LI  GA ++  DQDG + L  A
Sbjct: 371 STVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430

Query: 619 AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR 678
           A GG+ +V   L+   +  +  D   RT L+ AA+GG+ + +  L+++ A+ N  D EGR
Sbjct: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490

Query: 679 TALIAAAYMGHREIVEHLLDHGAEVN--HEDVDGRTALSVAALCVPASKGHASVVSLLID 736
           TAL  +   G+ + ++ LLD  A  N    + +  T L  A L     + H  V+  +++
Sbjct: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALL----GERH-EVIQFMLE 545

Query: 737 RGAEVDHCDKDGMTPLLVAAYEGH 760
            GA      +D     + A Y+G+
Sbjct: 546 HGALSIAAIQDIAAFKIQAVYKGY 569



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 56/215 (26%), Positives = 93/215 (43%), Gaps = 8/215 (3%)

Query: 448 TPLEAQEFALHLINSNLQLET-AELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAH 506
           T L A   + H+    L LE  A++    +   TP+  +        ++V+Q L+K GA 
Sbjct: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEM---GHKDVIQTLIKGGAR 415

Query: 507 VNSEDDRTSCIVRQAL--EREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
           V+  D     ++  A      D  + L++N  + N  D  GRT L  AAY G ++ + +L
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475

Query: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA--NINHTDQDGWTALRSAAWGG 622
           +   AD  I+D  G T L  +   G+   +  L+   A  N    +++ +T L  A  G 
Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE 535

Query: 623 HTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
             EV+  +L  G     A  D       A + G++
Sbjct: 536 RHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYK 570


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  207 bits (527), Expect = 6e-53
 Identities = 186/651 (28%), Positives = 291/651 (44%), Gaps = 41/651 (6%)

Query: 529  RTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQ 588
            R ++ N A  ++ D  GRT L     +  LD  + L+  GAD+   D    T L LAA++
Sbjct: 32   RLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQK 91

Query: 589  GHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL--YAGVKVDCADADSRT 646
            G+ + +  L+   AN    D +  T L         + ++ LL   A  +VD  D + +T
Sbjct: 92   GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQT 151

Query: 647  ALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHRE-----IVEHLLDHGA 701
            AL  +A+  + + V  L++H + +   D EG+  L  AA   H++      V  +LD   
Sbjct: 152  ALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAA--NHKDPSAVHTVRCILDAAP 209

Query: 702  E---VNHEDVDGRTALSVAALCVPASKGHASVVSLLID-RGAEVDHCDKDGMTPLLVAAY 757
                +N +D +GRT L  A      + G+ +VV +L       +   D    TPL  AA 
Sbjct: 210  TESLLNWQDYEGRTPLHFAV-----ADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAAL 264

Query: 758  EGHVDVVDLLLEGG-ADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRT 816
             GH  +V LLLE   +    +D+ G TPL  AA    A  V   L   +  D  D EGRT
Sbjct: 265  LGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRT 324

Query: 817  VLSIASAQGNVEVVRTLLD--RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
                A+ +G+ +V+RT+L     +D N  D  G T LH AA  GH    + L+E  A+ +
Sbjct: 325  SFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVD 384

Query: 875  EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934
              D     P   A + GH D +Q L++  + +D    DG + L  AAL G+ D+ ++L  
Sbjct: 385  ATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444

Query: 935  HGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEM 994
            +  + N +D  GR  L   A    +      +EN A+    D EGRTALH SC  G+++ 
Sbjct: 445  NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDA 504

Query: 995  VQVLIAYHADVNAADN--EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA 1052
            +++L+ + A  N  +N  E+ + L  A      +V+Q ++EHGA+        A     A
Sbjct: 505  IKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKIQA 564

Query: 1053 AQEGH------IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY-GASSL 1105
              +G+       D   +L++H       +Q  + A   A K       K  E+  G  S 
Sbjct: 565  VYKGYKVRKAFRDRKNLLMKH-------EQLRKDA--AAKKREEENKRKEAEQQKGRRSP 615

Query: 1106 NGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNG 1156
            + C P  +  +     Q + S+      K   +G+   G      RG P G
Sbjct: 616  DSCRPQALPCLPS--TQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRGSPGG 664



 Score =  114 bits (286), Expect = 5e-25
 Identities = 79/251 (31%), Positives = 126/251 (50%), Gaps = 9/251 (3%)

Query: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIE--DAHGHTPLT 583
           ++++  L + +  +  D  GRT    AA  GS DV+  ++S  +D++I   D +G T L 
Sbjct: 303 ETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALH 362

Query: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
            AA  GH   V  L+   A ++ TD    T L  A   GH +V+  L+  G +VD  D D
Sbjct: 363 AAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQD 422

Query: 644 SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEV 703
             + L  AA GG+ D+   L+++    N  D  GRT L  AAY G+   +  L+++ A+ 
Sbjct: 423 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADP 482

Query: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCD--KDGMTPLLVAAYEGHV 761
           N +D +GRTAL  +      + G+   + LL+D  A  +  +  ++  TPL  A      
Sbjct: 483 NIQDKEGRTALHWS-----CNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERH 537

Query: 762 DVVDLLLEGGA 772
           +V+  +LE GA
Sbjct: 538 EVIQFMLEHGA 548



 Score =  112 bits (279), Expect = 3e-24
 Identities = 83/264 (31%), Positives = 129/264 (48%), Gaps = 14/264 (5%)

Query: 506 HVNSEDD-----RTSCIVRQALEREDSIRTLLD--NGASVNQCDSNGRTLLANAAYSGSL 558
           H + +DD     RTS +       +D +RT+L   +   +N  D  G T L  AA SG +
Sbjct: 311 HPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHV 370

Query: 559 DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
             V LL+   A ++  D   HTPL  A   GH  V+  LI  GA ++  DQDG + L  A
Sbjct: 371 STVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWA 430

Query: 619 AWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR 678
           A GG+ +V   L+   +  +  D   RT L+ AA+GG+ + +  L+++ A+ N  D EGR
Sbjct: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490

Query: 679 TALIAAAYMGHREIVEHLLDHGAEVN--HEDVDGRTALSVAALCVPASKGHASVVSLLID 736
           TAL  +   G+ + ++ LLD  A  N    + +  T L  A L     + H  V+  +++
Sbjct: 491 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALL----GERH-EVIQFMLE 545

Query: 737 RGAEVDHCDKDGMTPLLVAAYEGH 760
            GA      +D     + A Y+G+
Sbjct: 546 HGALSIAAIQDIAAFKIQAVYKGY 569



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 56/215 (26%), Positives = 93/215 (43%), Gaps = 8/215 (3%)

Query: 448 TPLEAQEFALHLINSNLQLET-AELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAH 506
           T L A   + H+    L LE  A++    +   TP+  +        ++V+Q L+K GA 
Sbjct: 359 TALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEM---GHKDVIQTLIKGGAR 415

Query: 507 VNSEDDRTSCIVRQAL--EREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
           V+  D     ++  A      D  + L++N  + N  D  GRT L  AAY G ++ + +L
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475

Query: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA--NINHTDQDGWTALRSAAWGG 622
           +   AD  I+D  G T L  +   G+   +  L+   A  N    +++ +T L  A  G 
Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE 535

Query: 623 HTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
             EV+  +L  G     A  D       A + G++
Sbjct: 536 RHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYK 570


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 616

 Score =  203 bits (516), Expect = 1e-51
 Identities = 146/462 (31%), Positives = 234/462 (50%), Gaps = 20/462 (4%)

Query: 658  DIVLNLLQHGAEVNKADNEGRT---ALIAAAYMGHREIVEHL-------LDHGA----EV 703
            +I L+    GA++   D E +    AL+ AA     E++  L       LD  A     +
Sbjct: 123  EIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRM 182

Query: 704  NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763
              E+      +   +L    S G  + V  L+D G  V+   ++G + L +A   G+ ++
Sbjct: 183  KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242

Query: 764  VDLLLEGGADVDHTDNNGR-TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822
              +LL   A+V+   N G  TPL+AA+S G+  +V  LL   A V+S  + G T L+ A 
Sbjct: 243  AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302

Query: 823  AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
            A G V++V+ LL+ G +    ++ G TPL  AA  GH  +   L++ GA  N   N+ + 
Sbjct: 303  AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362

Query: 883  PFI-LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
              + LA  +GH D V+ LLE  ++ + +  +   AL  A ++GH ++  LL   GA VN 
Sbjct: 363  SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422

Query: 942  KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
                    L + A    + +A   +E GAN+E  + EG T L  +  +GH EMV +L+A 
Sbjct: 423  PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482

Query: 1002 HADVNAADNE-KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
             A++NA   E + +AL  A   G  +V   LI+ GA ++  C+   T L  A+QEGH+++
Sbjct: 483  GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 539

Query: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
            V+ LL  GA+ +     G TA+  A +NGH+ +  +L + GA
Sbjct: 540  VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581



 Score =  194 bits (492), Expect = 7e-49
 Identities = 126/404 (31%), Positives = 211/404 (52%), Gaps = 10/404 (2%)

Query: 638  DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697
            +    D+R+   A +  G  + V  LL  G  VN+   EG + L  A   G+ E+ + LL
Sbjct: 189  NAGQVDTRSLAEACS-DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247

Query: 698  DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757
               A V      G     +  L   +S G+  +V LL+   A+V+     G T L  A  
Sbjct: 248  AMHANVEDRGNKG----DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 303

Query: 758  EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-T 816
             G VD+V +LL  GA+++  + NG TPL+ AAS GH  V   LL  GA +++  +E + +
Sbjct: 304  GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 363

Query: 817  VLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876
             L++A  +G++++VR LL+ G D+ H+ D   T L  A  +GH  +   L++ GA+ N  
Sbjct: 364  ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 423

Query: 877  DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936
             +    P  LA+  GH +   +L+E  +N+++   +G   L  AA EGH ++V LL + G
Sbjct: 424  ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 483

Query: 937  ADVNCKDADGRPTLYILALENQLT-MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMV 995
            A++N +  + + T   LA     + +A++ ++ GA++E   +   T L  +  +GH+E+V
Sbjct: 484  ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 540

Query: 996  QVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD 1039
            + L+A  A+V+A      +AL  A   GH  V  +L++ GA +D
Sbjct: 541  KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584



 Score =  192 bits (489), Expect = 1e-48
 Identities = 157/521 (30%), Positives = 248/521 (47%), Gaps = 32/521 (6%)

Query: 504  GAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
            G    S++D  S +    L++ED     LDN        +     L++ A    L  V+ 
Sbjct: 90   GGASGSDEDEVSEVESFILDQED-----LDNPV----LKTTSEIFLSSTAEGADLRTVDP 140

Query: 564  LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA---------NINHTDQDGWTA 614
                  +  +E A    P  L      T  V+C +   A         N ++  Q    +
Sbjct: 141  ETQARLEALLEAAAFADPEVLRRL---TSSVSCALDEAAAALTRMKAENSHNAGQVDTRS 197

Query: 615  LRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKAD 674
            L  A   G    V  LL  G  V+    +  + L  A   G+ ++   LL   A V    
Sbjct: 198  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257

Query: 675  NEGR-TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSL 733
            N+G  T L+AA+  G+ +IV+ LL H A+VN +   G TAL+ A      + G   +V +
Sbjct: 258  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC-----AGGFVDIVKV 312

Query: 734  LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-HTDNNGRTPLLAAASMG 792
            L++ GA ++  +++G TPL+ AA  GHV+V  +LL+ GA ++ H++    + L  A   G
Sbjct: 313  LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 372

Query: 793  HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852
            H  +V  LL  GA  +    E  T L  A   G+VEV R LLD G   N   D+  +PL 
Sbjct: 373  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432

Query: 853  MAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYD 912
            +AA  GH  +   LIE+GA   E++++G  P + A++EGH + V +LL   +NI+ +  +
Sbjct: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492

Query: 913  GRN-ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGAN 971
             +  AL +A   G  ++ + L   GAD+   +      L   + E  L + +Y L +GAN
Sbjct: 493  TQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGAN 549

Query: 972  VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012
            V A+ A G TAL  +C  GH ++  VL+   AD++  ++ K
Sbjct: 550  VHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 590



 Score =  168 bits (425), Expect = 4e-41
 Identities = 118/358 (32%), Positives = 184/358 (51%), Gaps = 17/358 (4%)

Query: 495 EVLQLLVKAGAHVNSED-----DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLL 549
           E+ Q+L+    H N ED     D T  +   +    D ++ LL + A VN   + G T L
Sbjct: 241 ELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 298

Query: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-HTD 608
             A   G +D+V +L++ GA++E  + +GHTPL  AA  GH +V   L+  GA IN H++
Sbjct: 299 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 358

Query: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668
           +   +AL  A + GH ++V  LL AG   +    +  TAL  A   GH ++   LL  GA
Sbjct: 359 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 418

Query: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
           +VN   +   + L  AA  GH E+   L++ GA +   + +G T L  A     A +GH 
Sbjct: 419 QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA-----AREGHE 473

Query: 729 SVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
            +V+LL+ +GA ++   ++   T L +A   G  +V D L++ GAD+   +    TPL+ 
Sbjct: 474 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLME 530

Query: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 845
           A+  GH  +V  LL  GA V +  + G T L+ A   G+ +V   LL  G D + ++D
Sbjct: 531 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 588



 Score =  157 bits (397), Expect = 7e-38
 Identities = 109/339 (32%), Positives = 169/339 (49%), Gaps = 12/339 (3%)

Query: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
           ++++LL+   A VNS+    +  +  A      D ++ LL+ GA++   + NG T L  A
Sbjct: 275 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 334

Query: 553 AYSGSLDVVNLLVSRGADLEIE-DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
           A +G ++V  +L+  GA +    +    + LTLA  +GH  +V  L+  GA+  H   + 
Sbjct: 335 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 394

Query: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
            TAL  A   GH EV   LL +G +V+       + L  AA GGH ++   L++ GA + 
Sbjct: 395 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE 454

Query: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731
           + ++EG T L+ AA  GH E+V  LL  GA +N +  + +      A C     G + V 
Sbjct: 455 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC----GGFSEVA 510

Query: 732 SLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAAS 790
             LI  GA+++  C     TPL+ A+ EGH+++V  LL  GA+V  T   G T L  A  
Sbjct: 511 DFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566

Query: 791 MGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
            GH  V + LL  GA +D  +     +  I  A+  V V
Sbjct: 567 NGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQVRV 605



 Score =  155 bits (393), Expect = 2e-37
 Identities = 114/364 (31%), Positives = 176/364 (48%), Gaps = 6/364 (1%)

Query: 785  LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
            L  A S G  + V  LL  G +V+    EG ++L +A + G  E+ + LL    +   R 
Sbjct: 198  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257

Query: 845  DAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903
            + G  TPL  A+  G+  I + L+   A  N     G      A   G  D V++LL   
Sbjct: 258  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317

Query: 904  SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILAL-ENQLTMA 962
            +NI+    +G   L  AA  GH ++  +L  HGA +N    + + +   LA  +  L M 
Sbjct: 318  ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377

Query: 963  EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022
             + LE GA+ E    E  TAL  +C  GH+E+ ++L+   A VN   +   S L  AA  
Sbjct: 378  RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437

Query: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN-HADQFGRTA 1081
            GHV++  LLIE GA ++   ++G T L  AA+EGH ++V +LL  GA+ N   ++   TA
Sbjct: 438  GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497

Query: 1082 MRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST 1141
            + +A   G S++   L K GA    GCS   +   ++  L+ +   + S    +N   +T
Sbjct: 498  LTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS---GANVHATT 554

Query: 1142 GGGD 1145
              GD
Sbjct: 555  ATGD 558


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 [Homo
            sapiens]
          Length = 627

 Score =  197 bits (502), Expect = 5e-50
 Identities = 144/435 (33%), Positives = 224/435 (51%), Gaps = 14/435 (3%)

Query: 673  ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHE--DVDGRTALSVAALCVPASKGHASV 730
            AD E    L ++      E    L    AE +H    VD R   S+A  C   S G  + 
Sbjct: 167  ADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTR---SLAEAC---SDGDVNA 220

Query: 731  VSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR-TPLLAAA 789
            V  L+D G  V+   ++G + L +A   G+ ++  +LL   A+V+   N G  TPL+AA+
Sbjct: 221  VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280

Query: 790  SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 849
            S G+  +V  LL   A V+S  + G T L+ A A G V++V+ LL+ G +    ++ G T
Sbjct: 281  SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340

Query: 850  PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFI-LASQEGHYDCVQILLENKSNIDQ 908
            PL  AA  GH  +   L++ GA  N   N+ +   + LA  +GH D V+ LLE  ++ + 
Sbjct: 341  PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400

Query: 909  RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLEN 968
            +  +   AL  A ++GH ++  LL   GA VN         L + A    + +A   +E 
Sbjct: 401  KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 969  GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE-KRSALQSAAWQGHVKV 1027
            GAN+E  + EG T L  +  +GH EMV +L+A  A++NA   E + +AL  A   G  +V
Sbjct: 461  GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 1028 VQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAK 1087
               LI+ GA ++  C+   T L  A+QEGH+++V+ LL  GA+ +     G TA+  A +
Sbjct: 521  ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577

Query: 1088 NGHSQIIKLLEKYGA 1102
            NGH+ +  +L + GA
Sbjct: 578  NGHTDVADVLLQAGA 592



 Score =  194 bits (494), Expect = 4e-49
 Identities = 137/418 (32%), Positives = 207/418 (49%), Gaps = 44/418 (10%)

Query: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH-TPLTL 584
           +++R LLD G SVN+    G +LL  A  +G  ++  +L++  A++E     G  TPL  
Sbjct: 219 NAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA 278

Query: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
           A+  G+  +V  L+   A++N     G TAL  A  GG  ++V  LL  G  ++  + + 
Sbjct: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338

Query: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEV 703
            T L  AA  GH ++   LL HGA +N   NE + +AL  A Y GH ++V  LL+ GA+ 
Sbjct: 339 HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398

Query: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763
            H+  +  TAL  A +      GH  V  LL+D GA+V+       +PL +AA  GHV++
Sbjct: 399 EHKTDEMHTALMEACM-----DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453

Query: 764 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSIAS 822
             LL+E GA+++  ++ G TPL+ AA  GH  +V  LL  GA +++   E + T L++A 
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513

Query: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
             G  EV   L+  G D                           IE G  T         
Sbjct: 514 CGGFSEVADFLIKAGAD---------------------------IELGCST--------- 537

Query: 883 PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
           P + ASQEGH + V+ LL + +N+      G  AL  A   GH D+ ++L   GAD++
Sbjct: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595



 Score =  194 bits (492), Expect = 7e-49
 Identities = 126/404 (31%), Positives = 211/404 (52%), Gaps = 10/404 (2%)

Query: 638  DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697
            +    D+R+   A +  G  + V  LL  G  VN+   EG + L  A   G+ E+ + LL
Sbjct: 200  NAGQVDTRSLAEACS-DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258

Query: 698  DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757
               A V      G     +  L   +S G+  +V LL+   A+V+     G T L  A  
Sbjct: 259  AMHANVEDRGNKG----DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314

Query: 758  EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-T 816
             G VD+V +LL  GA+++  + NG TPL+ AAS GH  V   LL  GA +++  +E + +
Sbjct: 315  GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374

Query: 817  VLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876
             L++A  +G++++VR LL+ G D+ H+ D   T L  A  +GH  +   L++ GA+ N  
Sbjct: 375  ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 434

Query: 877  DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936
             +    P  LA+  GH +   +L+E  +N+++   +G   L  AA EGH ++V LL + G
Sbjct: 435  ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494

Query: 937  ADVNCKDADGRPTLYILALENQLT-MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMV 995
            A++N +  + + T   LA     + +A++ ++ GA++E   +   T L  +  +GH+E+V
Sbjct: 495  ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 551

Query: 996  QVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVD 1039
            + L+A  A+V+A      +AL  A   GH  V  +L++ GA +D
Sbjct: 552  KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595



 Score =  192 bits (487), Expect = 3e-48
 Identities = 135/413 (32%), Positives = 213/413 (51%), Gaps = 11/413 (2%)

Query: 603  NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 662
            N ++  Q    +L  A   G    V  LL  G  V+    +  + L  A   G+ ++   
Sbjct: 197  NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256

Query: 663  LLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721
            LL   A V    N+G  T L+AA+  G+ +IV+ LL H A+VN +   G TAL+ A    
Sbjct: 257  LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC--- 313

Query: 722  PASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-HTDNN 780
              + G   +V +L++ GA ++  +++G TPL+ AA  GHV+V  +LL+ GA ++ H++  
Sbjct: 314  --AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371

Query: 781  GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDE 840
              + L  A   GH  +V  LL  GA  +    E  T L  A   G+VEV R LLD G   
Sbjct: 372  KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431

Query: 841  NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900
            N   D+  +PL +AA  GH  +   LIE+GA   E++++G  P + A++EGH + V +LL
Sbjct: 432  NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491

Query: 901  ENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQL 959
               +NI+ +  + +  AL +A   G  ++ + L   GAD+   +      L   + E  L
Sbjct: 492  AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHL 548

Query: 960  TMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012
             + +Y L +GANV A+ A G TAL  +C  GH ++  VL+   AD++  ++ K
Sbjct: 549  ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601



 Score =  168 bits (425), Expect = 4e-41
 Identities = 118/358 (32%), Positives = 184/358 (51%), Gaps = 17/358 (4%)

Query: 495 EVLQLLVKAGAHVNSED-----DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLL 549
           E+ Q+L+    H N ED     D T  +   +    D ++ LL + A VN   + G T L
Sbjct: 252 ELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309

Query: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-HTD 608
             A   G +D+V +L++ GA++E  + +GHTPL  AA  GH +V   L+  GA IN H++
Sbjct: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369

Query: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668
           +   +AL  A + GH ++V  LL AG   +    +  TAL  A   GH ++   LL  GA
Sbjct: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429

Query: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
           +VN   +   + L  AA  GH E+   L++ GA +   + +G T L  A     A +GH 
Sbjct: 430 QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA-----AREGHE 484

Query: 729 SVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
            +V+LL+ +GA ++   ++   T L +A   G  +V D L++ GAD+   +    TPL+ 
Sbjct: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLME 541

Query: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 845
           A+  GH  +V  LL  GA V +  + G T L+ A   G+ +V   LL  G D + ++D
Sbjct: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599



 Score =  157 bits (397), Expect = 7e-38
 Identities = 109/339 (32%), Positives = 169/339 (49%), Gaps = 12/339 (3%)

Query: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
           ++++LL+   A VNS+    +  +  A      D ++ LL+ GA++   + NG T L  A
Sbjct: 286 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345

Query: 553 AYSGSLDVVNLLVSRGADLEIE-DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
           A +G ++V  +L+  GA +    +    + LTLA  +GH  +V  L+  GA+  H   + 
Sbjct: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 405

Query: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
            TAL  A   GH EV   LL +G +V+       + L  AA GGH ++   L++ GA + 
Sbjct: 406 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE 465

Query: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731
           + ++EG T L+ AA  GH E+V  LL  GA +N +  + +      A C     G + V 
Sbjct: 466 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC----GGFSEVA 521

Query: 732 SLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAAS 790
             LI  GA+++  C     TPL+ A+ EGH+++V  LL  GA+V  T   G T L  A  
Sbjct: 522 DFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577

Query: 791 MGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
            GH  V + LL  GA +D  +     +  I  A+  V V
Sbjct: 578 NGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQVRV 616



 Score =  155 bits (393), Expect = 2e-37
 Identities = 114/364 (31%), Positives = 176/364 (48%), Gaps = 6/364 (1%)

Query: 785  LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
            L  A S G  + V  LL  G +V+    EG ++L +A + G  E+ + LL    +   R 
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 845  DAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903
            + G  TPL  A+  G+  I + L+   A  N     G      A   G  D V++LL   
Sbjct: 269  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 904  SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILAL-ENQLTMA 962
            +NI+    +G   L  AA  GH ++  +L  HGA +N    + + +   LA  +  L M 
Sbjct: 329  ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388

Query: 963  EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022
             + LE GA+ E    E  TAL  +C  GH+E+ ++L+   A VN   +   S L  AA  
Sbjct: 389  RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448

Query: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN-HADQFGRTA 1081
            GHV++  LLIE GA ++   ++G T L  AA+EGH ++V +LL  GA+ N   ++   TA
Sbjct: 449  GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508

Query: 1082 MRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST 1141
            + +A   G S++   L K GA    GCS   +   ++  L+ +   + S    +N   +T
Sbjct: 509  LTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS---GANVHATT 565

Query: 1142 GGGD 1145
              GD
Sbjct: 566  ATGD 569


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
            sapiens]
          Length = 765

 Score =  173 bits (439), Expect = 9e-43
 Identities = 121/381 (31%), Positives = 179/381 (46%), Gaps = 5/381 (1%)

Query: 639  CADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD 698
            C   +  T L      G  + V  LL H  +V+     G T L+ AA     ++   LL 
Sbjct: 357  CIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416

Query: 699  HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE 758
            HGA+ N  D DG   L  AA       G      LL+D GA VD  +++G TPL +AA  
Sbjct: 417  HGADANRVDEDGWAPLHFAA-----QNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQN 471

Query: 759  GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 818
               +V  LL+   AD +  +  G+TPL  AA  GH S+V  L   GA +D+     RT L
Sbjct: 472  NFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPL 531

Query: 819  SIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDN 878
             +A  +G V  ++ LL  G   +  D +G+ PLH AA  G  LIC+ L+  GA      +
Sbjct: 532  HLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTH 591

Query: 879  DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938
             G  P  LA+ +GH + + +L E+ +N+   G      L +AA  G   +V  L   GAD
Sbjct: 592  QGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGAD 651

Query: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
             N  +  G   L++    +        LE+ ANV A +  G T  H++  +G+  +++VL
Sbjct: 652  PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711

Query: 999  IAYHADVNAADNEKRSALQSA 1019
            +   A ++  D    + LQ A
Sbjct: 712  VEAGAQLDVQDGVSCTPLQLA 732



 Score =  172 bits (437), Expect = 2e-42
 Identities = 116/377 (30%), Positives = 183/377 (48%), Gaps = 5/377 (1%)

Query: 556 GSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTAL 615
           GS++ V LL++   D++ + A G+TPL +AA+     +   L+  GA+ N  D+DGW  L
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432

Query: 616 RSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADN 675
             AA  G       LL  G  VD  + +  T L  AA    E++   L+   A+ N  + 
Sbjct: 433 HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492

Query: 676 EGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLI 735
           EG+T L  AAY GH  +V+ L   GAE++ +  + RT L +A       +G    +  L+
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLA-----VERGKVRAIQHLL 547

Query: 736 DRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHAS 795
             GA  D  D+ G  PL  AA  G   +  +LL  GA ++   + G TPL  AA  GH  
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607

Query: 796 VVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAA 855
           +++ L    A + ++ +   T L +A+  G   VV  LL  G D N  + +GWTPLH+A 
Sbjct: 608 IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV 667

Query: 856 FEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN 915
                L    L+E  A  +  +  G  P  LA+ +G+   +++L+E  + +D +      
Sbjct: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCT 727

Query: 916 ALRVAALEGHRDIVELL 932
            L++A     + I+  L
Sbjct: 728 PLQLALRSRKQGIMSFL 744



 Score =  171 bits (433), Expect = 5e-42
 Identities = 139/454 (30%), Positives = 211/454 (46%), Gaps = 16/454 (3%)

Query: 520 QALEREDSIRTLLDNGASVNQ------CDSNGRTLLANAAYSGSLDVVNLLVSRGADLEI 573
           +AL R+ S +  L     VN+       DS+    L  A     L     LV R  +L I
Sbjct: 302 KALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRAL---QLSDRKNLVPRDEELCI 358

Query: 574 EDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633
            + +  TPL     QG  + V  L+    +++     G+T L  AA     ++ + LL  
Sbjct: 359 YE-NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 634 GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIV 693
           G   +  D D    L  AA  G +     LL HGA V+  + EG T L  AA      + 
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477

Query: 694 EHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLL 753
             L+   A+ N  + +G+T L VAA       GH S+V LL  +GAE+D   ++  TPL 
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYF-----GHVSLVKLLTSQGAELDAQQRNLRTPLH 532

Query: 754 VAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSE 813
           +A   G V  +  LL+ GA  D  D +G  PL  AA+ G   +   LL +GA+++    +
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ 592

Query: 814 GRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGART 873
           G T L +A+ +G++E++  L +   +        WTPLH+AA  G   +  AL++ GA  
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652

Query: 874 NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933
           N  +  G  P  LA Q   +  V  LLE+ +N+  R   G     +AAL+G+  I+++L 
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712

Query: 934 SHGADVNCKDADGRPTLYILALENQLTMAEYFLE 967
             GA ++ +D      L  LAL ++      FLE
Sbjct: 713 EAGAQLDVQDGVSCTPLQ-LALRSRKQGIMSFLE 745



 Score =  166 bits (419), Expect = 2e-40
 Identities = 122/389 (31%), Positives = 183/389 (47%), Gaps = 2/389 (0%)

Query: 724  SKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRT 783
            ++G    V LL+    +VD     G TPLL+AA +   D+  LLL  GAD +  D +G  
Sbjct: 371  AQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWA 430

Query: 784  PLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHR 843
            PL  AA  G       LL  GA VD+ + EG T L +A+      V R L+ R  D N  
Sbjct: 431  PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490

Query: 844  DDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903
            +  G TPLH+AA+ GH  + + L  QGA  +    + R P  LA + G    +Q LL++ 
Sbjct: 491  EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 904  SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAE 963
            +  D     G   L  AA  G   I ++L  +GA +      G   L++ A +  L +  
Sbjct: 551  AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 964  YFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQG 1023
               E+ AN+ A  A   T LH++   G   +V  L+   AD NAA+    + L  A  + 
Sbjct: 611  LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670

Query: 1024 HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMR 1083
                V  L+EH A V      G T   +AA +G+  +++VL+E GA  +  D    T ++
Sbjct: 671  TFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQ 730

Query: 1084 VAAKNGHSQIIKLLE--KYGASSLNGCSP 1110
            +A ++    I+  LE  +   ++L G  P
Sbjct: 731  LALRSRKQGIMSFLEGKEPSVATLGGSKP 759



 Score =  162 bits (409), Expect = 3e-39
 Identities = 119/398 (29%), Positives = 189/398 (47%), Gaps = 6/398 (1%)

Query: 749  MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVD 808
            +TPL     +G V+ V LLL    DVD    +G TPLL AA      +   LL  GA  +
Sbjct: 363  VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 809  SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE 868
             +D +G   L  A+  G+    R LLD G   + ++  GWTPLH+AA      +   L+ 
Sbjct: 423  RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS 482

Query: 869  QGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDI 928
            + A  N  + +G+ P  +A+  GH   V++L    + +D +  + R  L +A   G    
Sbjct: 483  RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542

Query: 929  VELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCW 988
            ++ L   GA  +  D  G   L+  A   +  + +  L  GA++E    +G T LH++ +
Sbjct: 543  IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602

Query: 989  QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048
            +GH+E++ +L   HA++ A      + L  AA  G   VV  L++ GA  +     G T 
Sbjct: 603  KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTP 662

Query: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLN 1106
            L +A Q      V  LLEH A+ +  ++ G T   +AA  G++ I+K+L + GA     +
Sbjct: 663  LHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722

Query: 1107 GCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGG 1144
            G S +P+    Q  L+S    + S       S +T GG
Sbjct: 723  GVSCTPL----QLALRSRKQGIMSFLEGKEPSVATLGG 756



 Score =  148 bits (373), Expect = 4e-35
 Identities = 100/337 (29%), Positives = 167/337 (49%), Gaps = 2/337 (0%)

Query: 780  NGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
            N  TPL    + G    V  LL     VD   + G T L IA+     ++   LL  G D
Sbjct: 361  NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 840  ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
             N  D+ GW PLH AA  G       L++ GA  +  + +G  P  LA+Q    +  ++L
Sbjct: 421  ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480

Query: 900  LENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQL 959
            +  +++ +    +G+  L VAA  GH  +V+LL S GA+++ +  + R  L++     ++
Sbjct: 481  VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540

Query: 960  TMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019
               ++ L++GA  +A D  G   LH +  +G   + ++L+ Y A +    ++  + L  A
Sbjct: 541  RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600

Query: 1020 AWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGR 1079
            A++GH++++ LL E  A +        T L +AA+ G   VV  LL+ GADPN A+Q G 
Sbjct: 601  AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGW 660

Query: 1080 TAMRVAA-KNGHSQIIKLLEKY-GASSLNGCSPSPVH 1114
            T + +A  ++    +I LLE +    + N    +P H
Sbjct: 661  TPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAH 697



 Score =  147 bits (370), Expect = 9e-35
 Identities = 106/371 (28%), Positives = 182/371 (49%), Gaps = 3/371 (0%)

Query: 705  HE-DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763
            HE DVD +TA     L + A      + +LL+  GA+ +  D+DG  PL  AA  G    
Sbjct: 384  HEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGT 443

Query: 764  VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASA 823
              LLL+ GA VD  +  G TPL  AA     +V   L+   A  +  ++EG+T L +A+ 
Sbjct: 444  ARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503

Query: 824  QGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIP 883
             G+V +V+ L  +G + + +     TPLH+A   G     + L++ GA  + +D  G  P
Sbjct: 504  FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563

Query: 884  FILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD 943
               A+  G Y   ++LL   ++++   + G   L +AA +GH +I+ LL    A++    
Sbjct: 564  LHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALG 623

Query: 944  ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003
            A     L++ A   +  +    L+ GA+  A++  G T LH++  +     V  L+ +HA
Sbjct: 624  AVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHA 683

Query: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQV 1063
            +V+A +    +    AA +G+  ++++L+E GA +D       T L +A +     ++  
Sbjct: 684  NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSF 743

Query: 1064 LLEHGADPNHA 1074
            L   G +P+ A
Sbjct: 744  L--EGKEPSVA 752



 Score =  141 bits (356), Expect = 4e-33
 Identities = 112/363 (30%), Positives = 168/363 (46%), Gaps = 7/363 (1%)

Query: 493 EQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552
           EQ  L L  +      +    T  ++    ++ D    LL +GA  N+ D +G   L  A
Sbjct: 376 EQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFA 435

Query: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
           A +G      LL+  GA ++ ++  G TPL LAA+     V   L+   A+ N  + +G 
Sbjct: 436 AQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGK 495

Query: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
           T L  AA+ GH  +V  L   G ++D    + RT L  A   G    + +LL+ GA  + 
Sbjct: 496 TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDA 555

Query: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
            D  G   L  AA  G   I + LL +GA +      G T L +AA      KGH  ++ 
Sbjct: 556 LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY-----KGHLEIIH 610

Query: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL-LAAASM 791
           LL +  A +        TPL +AA  G   VV  LL+ GAD +  + +G TPL LA    
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRS 670

Query: 792 GHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL 851
              SV+N LL   A V + +  G T   +A+ +GN  +++ L++ G   + +D    TPL
Sbjct: 671 TFLSVIN-LLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729

Query: 852 HMA 854
            +A
Sbjct: 730 QLA 732



 Score =  133 bits (334), Expect = 1e-30
 Identities = 108/332 (32%), Positives = 160/332 (48%), Gaps = 7/332 (2%)

Query: 492 KEQEVLQLLVKAGAHVNSEDDRTSCIVRQALERED--SIRTLLDNGASVNQCDSNGRTLL 549
           ++ ++  LL+  GA  N  D+     +  A +  D  + R LLD+GA V+  +  G T L
Sbjct: 406 QQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPL 465

Query: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQ 609
             AA +   +V  LLVSR AD  + +A G TPL +AA  GH  +V  L   GA ++   +
Sbjct: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525

Query: 610 DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAE 669
           +  T L  A   G    +  LL +G   D  D      L  AA  G   I   LL++GA 
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585

Query: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHAS 729
           +    ++G T L  AAY GH EI+ HLL      +H ++    A++   L + A  G  +
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEII-HLLAE----SHANMGALGAVNWTPLHLAARHGEEA 640

Query: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
           VVS L+  GA+ +  ++ G TPL +A        V  LLE  A+V   +  G TP   AA
Sbjct: 641 VVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAA 700

Query: 790 SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821
             G+ +++  L+  GA +D  D    T L +A
Sbjct: 701 LKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 43/155 (27%), Positives = 74/155 (47%), Gaps = 6/155 (3%)

Query: 448 TPLEAQEFALHLINSNLQLET-AELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGAH 506
           TPL    +  HL   +L  E+ A +      N TP+  +       E+ V+  L++ GA 
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARH---GEEAVVSALLQCGAD 651

Query: 507 VNSEDDRTSCIVRQALERED--SIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
            N+ +      +  A++R    S+  LL++ A+V+  +  G T    AA  G+  ++ +L
Sbjct: 652 PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711

Query: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG 599
           V  GA L+++D    TPL LA R     +++ L G
Sbjct: 712 VEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  171 bits (433), Expect = 5e-42
 Identities = 121/331 (36%), Positives = 157/331 (47%), Gaps = 16/331 (4%)

Query: 611 GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
           GW  L  A W G   +V+ LL  G  V+  D   RT L  A   GH  +V  LLQ GA V
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 671 NKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASV 730
              D  GRTAL  AA+ GH  + E LL  GA        G T L  AA     + GH  +
Sbjct: 101 GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAA-----ALGHTLL 155

Query: 731 VSLLIDRG----AEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLL 786
            + L++      A  +  D  G T    AA  G + V++LL  GGA +D         LL
Sbjct: 156 AARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA-------LL 208

Query: 787 AAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDA 846
            AA+ G  + +  LL  GA VD+ D  G T L +A+A G  + +  LL  G D   RD  
Sbjct: 209 VAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRH 268

Query: 847 GWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNI 906
           G + LH AA  GH L  + L+ QGA  +  D  G  P   AS+EGH +    LL+  + +
Sbjct: 269 GRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQV 328

Query: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
           D  G+  +  L +AA  GH   V LL S GA
Sbjct: 329 DATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score =  166 bits (421), Expect = 1e-40
 Identities = 124/356 (34%), Positives = 167/356 (46%), Gaps = 36/356 (10%)

Query: 748  GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807
            G   LL A + G   +V  LL  GA V+  D+ GRTPL  A   GHA +V  LL  GA V
Sbjct: 41   GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 808  DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALI 867
             ++D  GRT L  A+  G+  V   LL RG     R   G TPLH AA  GH L+   L+
Sbjct: 101  GAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLL 160

Query: 868  EQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD 927
            E           G  P    ++                 D RG+    A   AA  G   
Sbjct: 161  EA---------PGPGPAAAEAE-----------------DARGW---TAAHWAAAGGRLA 191

Query: 928  IVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSC 987
            ++ELL + GA +     DG   L + A   +     + L  GA V+A D  G TAL ++ 
Sbjct: 192  VLELLAAGGAGL-----DG--ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAA 244

Query: 988  WQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGAT 1047
              G  + ++VL+ + AD    D   RSAL  AA +GH+  VQLL+  GA VD     G T
Sbjct: 245  ALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLT 304

Query: 1048 ALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
             L  A++EGH++V   LL+ GA  +      +T + +AA+ GH   + LL   GAS
Sbjct: 305  PLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360



 Score =  162 bits (411), Expect = 2e-39
 Identities = 131/357 (36%), Positives = 171/357 (47%), Gaps = 27/357 (7%)

Query: 522 LEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTP 581
           L+ E+++ T  + G SV Q    G   L  A + G   +V  L+ +GA +E  D  G TP
Sbjct: 23  LDSEEALGTRTE-GPSVVQ----GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTP 77

Query: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD 641
           L LA  +GH  +V  L+  GA +   D+ G TAL  AAW GH+ V   LL  G       
Sbjct: 78  LHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARS 137

Query: 642 ADSRTALRAAAWGGHEDIVLNLLQ----HGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697
               T L  AA  GH  +   LL+      A     D  G TA   AA  G   ++E L 
Sbjct: 138 GTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLA 197

Query: 698 DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757
             GA      +DG       AL V A+ G  + +  L+ RGA VD  D  G T L +AA 
Sbjct: 198 AGGA-----GLDG-------ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAA 245

Query: 758 EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTV 817
            G    +++LL  GAD    D +GR+ L  AA+ GH   V  L+  GA VD+ D+ G T 
Sbjct: 246 LGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTP 305

Query: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGW---TPLHMAAFEGHRLICEALIEQGA 871
           L  AS +G+VEV   LLDRG      D  GW   TPLH+AA  GH      L+ +GA
Sbjct: 306 LHHASREGHVEVAGCLLDRGAQV---DATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score =  161 bits (407), Expect = 5e-39
 Identities = 124/313 (39%), Positives = 153/313 (48%), Gaps = 18/313 (5%)

Query: 500 LVKAGAHVNSEDDRTSCIVRQALEREDS--IRTLLDNGASVNQCDSNGRTLLANAAYSGS 557
           L++ GA V   D      +  A+ R  +  +R LL  GA V   D  GRT L  AA+ G 
Sbjct: 60  LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119

Query: 558 LDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLI---GCG-ANINHTDQDGWT 613
             V  LL+ RGA        G TPL  AA  GHT +   L+   G G A     D  GWT
Sbjct: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWT 179

Query: 614 ALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKA 673
           A   AA GG   V+  L   G  +D        AL  AA  G    +  LL  GA V+  
Sbjct: 180 AAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLARGARVDAR 232

Query: 674 DNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSL 733
           D  G TAL  AA +G  + +E LL HGA+    D  GR+AL  AA     ++GH   V L
Sbjct: 233 DGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAA-----ARGHLLAVQL 287

Query: 734 LIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGH 793
           L+ +GAEVD  D  G+TPL  A+ EGHV+V   LL+ GA VD T    +TPL  AA  GH
Sbjct: 288 LVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGH 347

Query: 794 ASVVNTLLFWGAA 806
              V  LL  GA+
Sbjct: 348 GPTVGLLLSRGAS 360



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 64/173 (36%), Positives = 83/173 (47%), Gaps = 5/173 (2%)

Query: 496 VLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYS 555
           VL+LL   GA ++      + +V  A  R  ++R LL  GA V+  D  G T L  AA  
Sbjct: 192 VLELLAAGGAGLDG-----ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAAL 246

Query: 556 GSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTAL 615
           G    + +L+  GAD  I D HG + L  AA +GH   V  L+  GA ++  D  G T L
Sbjct: 247 GRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPL 306

Query: 616 RSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668
             A+  GH EV   LL  G +VD      +T L  AA  GH   V  LL  GA
Sbjct: 307 HHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGA 359



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 38/101 (37%), Positives = 59/101 (58%), Gaps = 2/101 (1%)

Query: 1016 LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHAD 1075
            L  A W+G   +V  L+  GA V+   + G T L +A   GH  +V++LL+ GA     D
Sbjct: 45   LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104

Query: 1076 QFGRTAMRVAAKNGHSQIIKLLEKYGASSL--NGCSPSPVH 1114
            + GRTA+  AA +GHS++ +LL + GAS+   +G   +P+H
Sbjct: 105  RAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLH 145



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 44/128 (34%), Positives = 63/128 (49%), Gaps = 1/128 (0%)

Query: 975  SDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 1034
            S  +G   L  + W+G   +V  L+   A V   D+  R+ L  A  +GH  +V+LL++ 
Sbjct: 37   SVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQR 96

Query: 1035 GAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQI- 1093
            GA V      G TAL  AA  GH  V ++LL+ GA        G T +  AA  GH+ + 
Sbjct: 97   GAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLA 156

Query: 1094 IKLLEKYG 1101
             +LLE  G
Sbjct: 157  ARLLEAPG 164



 Score = 37.0 bits (84), Expect = 0.14
 Identities = 21/59 (35%), Positives = 29/59 (49%)

Query: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
            QG   L  A   G   +V  LL  GA     D  GRT + +A   GH+ +++LL + GA
Sbjct: 40   QGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGA 98


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  165 bits (418), Expect = 3e-40
 Identities = 103/306 (33%), Positives = 162/306 (52%), Gaps = 6/306 (1%)

Query: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
           VNQ + +G   L  AA  G++ ++ LL+ RG+ ++++D  G   +  AAR GH   +  L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657
                 ++  D+ G  AL  AA  GH +V   L   G   +  D +  T L  AAW G+ 
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491

Query: 658 DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
            +   L + G  VN  + EG T L+ A+  G+ +IVE L +HGA++N  D DG  AL +A
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551

Query: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
                  +    V+  L+ +G  VD+ D+ G TPL VA  +G++ +V  L E   ++D +
Sbjct: 552 -----VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDIS 606

Query: 778 DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
           +  GRTPL  AA+ G   VV  L   GA+V+++ ++G+T   +A ++ + E V  LL R 
Sbjct: 607 NKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQH-EHVAGLLARL 665

Query: 838 LDENHR 843
             + HR
Sbjct: 666 RKDTHR 671



 Score =  147 bits (372), Expect = 5e-35
 Identities = 101/357 (28%), Positives = 172/357 (48%), Gaps = 3/357 (0%)

Query: 711  RTALSVAALCVPASKGHASVVSLLIDRGAE-VDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
            + ++ + +LC   S+   S  ++ + R  + +D  D   M  ++ A  + +V  +  LL 
Sbjct: 306  KQSVRLISLCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLG 365

Query: 770  G--GADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNV 827
                 DV+  + +G  PLL AA  G+  ++  L+  G+ +D  D  G   +  A+  G+V
Sbjct: 366  SLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHV 425

Query: 828  EVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILA 887
            + ++ L +     + +D +G   LH+AA  GH  + + L   G+  N  D +   P   A
Sbjct: 426  DTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485

Query: 888  SQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGR 947
            +  G+Y   + L E   N++ +  +G   L  A+  G+ DIVE L  HGAD+N  D DG 
Sbjct: 486  AWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGH 545

Query: 948  PTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA 1007
              L++     Q+ + +  L  G  V+  D  G T LHV+C  G+M +V  L   + +++ 
Sbjct: 546  IALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI 605

Query: 1008 ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
            ++   R+ L  AA  G + VV+ L   GA V+     G TA  +A  E H  V  +L
Sbjct: 606  SNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score =  145 bits (366), Expect = 3e-34
 Identities = 94/301 (31%), Positives = 157/301 (52%), Gaps = 5/301 (1%)

Query: 808  DSIDSEGRTVLSI---ASAQGNVEVVRTLLDR--GLDENHRDDAGWTPLHMAAFEGHRLI 862
            D++D E   V+     A    NV  ++ LL      D N  +  G  PL +AA  G+  I
Sbjct: 335  DTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQI 394

Query: 863  CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAAL 922
             + LI++G+R +  D  G      A++ GH D ++ L ENK  +D +   G  AL VAA 
Sbjct: 395  LQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAAR 454

Query: 923  EGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982
             GH D+ +LL S G++ N +D +    L+  A     ++A+   E G NV   + EG T 
Sbjct: 455  YGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETP 514

Query: 983  LHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 1042
            L  +  +G+ ++V+ L  + AD+NA D +   AL  A  +  ++V++ L+  G  VD+  
Sbjct: 515  LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574

Query: 1043 NQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
              G T L +A ++G++ +V  L E   + + ++++GRT + +AA NG   +++ L   GA
Sbjct: 575  RHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGA 634

Query: 1103 S 1103
            S
Sbjct: 635  S 635



 Score =  138 bits (347), Expect = 4e-32
 Identities = 97/316 (30%), Positives = 146/316 (46%), Gaps = 7/316 (2%)

Query: 693  VEHLLDH--GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMT 750
            ++HLL      +VN  +  G   L +AA C     G+  ++ LLI RG+ +D  DK G  
Sbjct: 360  LQHLLGSLSNYDVNQPNKHGTPPLLIAAGC-----GNIQILQLLIKRGSRIDVQDKGGSN 414

Query: 751  PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
             +  AA  GHVD +  L E    +D  D +G   L  AA  GHA V   L  +G+  +  
Sbjct: 415  AVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQ 474

Query: 811  DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
            D E  T L  A+  G   V + L + G + N ++  G TPL  A+  G+  I E L E G
Sbjct: 475  DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHG 534

Query: 871  ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930
            A  N  D DG I   LA +    + ++ LL     +D +   G   L VA  +G+  IV 
Sbjct: 535  ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVV 594

Query: 931  LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990
             L     +++  +  GR  L++ A    L +  Y    GA+VEA   +G+TA  ++  + 
Sbjct: 595  ALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQ 654

Query: 991  HMEMVQVLIAYHADVN 1006
            H  +  +L     D +
Sbjct: 655  HEHVAGLLARLRKDTH 670



 Score =  137 bits (345), Expect = 7e-32
 Identities = 90/273 (32%), Positives = 132/273 (48%), Gaps = 5/273 (1%)

Query: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
           ++ L+  G+ ++  D  G   +  AA  G +D +  L      L+++D  G   L +AAR
Sbjct: 395 LQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAAR 454

Query: 588 QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTA 647
            GH  V   L   G+N N  D++  T L  AAW G+  V  AL  AG  V+  + +  T 
Sbjct: 455 YGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETP 514

Query: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
           L  A+  G+ DIV  L +HGA++N  D +G  AL  A      E+++ LL  G  V+++D
Sbjct: 515 LLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQD 574

Query: 708 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
             G T L VA        G+  +V  L +    +D  +K G TPL +AA  G +DVV  L
Sbjct: 575 RHGNTPLHVA-----CKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYL 629

Query: 768 LEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
              GA V+    +G+T    A S  H  V   L
Sbjct: 630 CLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score =  123 bits (308), Expect = 1e-27
 Identities = 87/335 (25%), Positives = 153/335 (45%), Gaps = 5/335 (1%)

Query: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
            V+  +  G   L IA+  GN+++++ L+ RG   + +D  G   ++ AA  GH    + L
Sbjct: 372  VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 867  IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
             E     +  D  G +   +A++ GH D  Q+L    SN + +  +    L  AA  G+ 
Sbjct: 432  SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491

Query: 927  DIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVS 986
             + + L   G +VN K+ +G   L   +      + E   E+GA++ A D +G  ALH++
Sbjct: 492  SVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551

Query: 987  CWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGA 1046
              +  ME+++ L++    V+  D    + L  A   G++ +V  L E    +D +   G 
Sbjct: 552  VRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGR 611

Query: 1047 TALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLN 1106
            T L +AA  G +DVV+ L   GA        G+TA  +A    H  +  LL +    +  
Sbjct: 612  TPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671

Query: 1107 GCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST 1141
            G     +   + +P Q+L  +++      + SG T
Sbjct: 672  G-----LFIQQLRPTQNLQPRIKLKLFGHSGSGKT 701



 Score =  114 bits (284), Expect = 9e-25
 Identities = 86/275 (31%), Positives = 128/275 (46%), Gaps = 7/275 (2%)

Query: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
           ++LQLL+K G+ ++ +D   S  V  A      D+++ L +N   ++  D +G   L  A
Sbjct: 393 QILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVA 452

Query: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
           A  G  DV  LL S G++  I+D    TPL  AA  G+  V   L   G N+N  +++G 
Sbjct: 453 ARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGE 512

Query: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
           T L +A+  G+ ++V  L   G  ++  D D   AL  A      +++  LL  G  V+ 
Sbjct: 513 TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDY 572

Query: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVS 732
            D  G T L  A   G+  IV  L +    ++  +  GRT L +A     A+ G   VV 
Sbjct: 573 QDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA-----ANNGILDVVR 627

Query: 733 LLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLL 767
            L   GA V+    DG T   +A  E H  V  LL
Sbjct: 628 YLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,033,444
Number of Sequences: 37866
Number of extensions: 2357481
Number of successful extensions: 19961
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 401
Number of HSP's successfully gapped in prelim test: 244
Number of HSP's that attempted gapping in prelim test: 8130
Number of HSP's gapped (non-prelim): 5073
length of query: 1429
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1314
effective length of database: 13,892,928
effective search space: 18255307392
effective search space used: 18255307392
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.