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Search of human proteins with 62912470
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
(967 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 1956 0.0
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 1804 0.0
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 1510 0.0
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 970 0.0
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 776 0.0
gi|31657138 follicle stimulating hormone receptor isoform 1 prec... 174 3e-43
gi|225579152 insulin-like growth factor binding protein, acid la... 167 4e-41
gi|4826772 insulin-like growth factor binding protein, acid labi... 167 4e-41
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 165 2e-40
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 165 2e-40
gi|31657136 follicle stimulating hormone receptor isoform 2 prec... 165 2e-40
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 165 2e-40
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu... 151 3e-36
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre... 147 5e-35
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 147 6e-35
gi|45505137 podocan [Homo sapiens] 146 1e-34
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 140 4e-33
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 138 3e-32
gi|4759146 slit homolog 2 [Homo sapiens] 136 1e-31
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 136 1e-31
gi|188528675 slit homolog 1 [Homo sapiens] 132 2e-30
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 132 2e-30
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 131 3e-30
gi|11321571 slit homolog 3 [Homo sapiens] 130 8e-30
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 128 2e-29
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 125 1e-28
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 124 6e-28
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 120 8e-27
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 120 8e-27
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 120 8e-27
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 1956 bits (5068), Expect = 0.0
Identities = 967/967 (100%), Positives = 967/967 (100%)
Query: 1 MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAV 60
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAV
Sbjct: 1 MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAV 60
Query: 61 PGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 120
PGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM
Sbjct: 61 PGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 120
Query: 121 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR 180
LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR
Sbjct: 121 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR 180
Query: 181 ALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLD 240
ALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLD
Sbjct: 181 ALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLD 240
Query: 241 LNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 300
LNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA
Sbjct: 241 LNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 300
Query: 301 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS
Sbjct: 301 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
Query: 361 HNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420
HNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST
Sbjct: 361 HNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420
Query: 421 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC
Sbjct: 421 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
Query: 481 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPH 540
PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPH
Sbjct: 481 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPH 540
Query: 541 PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFV 600
PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFV
Sbjct: 541 PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFV 600
Query: 601 VGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLL 660
VGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLL
Sbjct: 601 VGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLL 660
Query: 661 TLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY 720
TLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY
Sbjct: 661 TLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY 720
Query: 721 APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIF 780
APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIF
Sbjct: 721 APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIF 780
Query: 781 ADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRR 840
ADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRR
Sbjct: 781 ADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRR 840
Query: 841 LRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVT 900
LRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVT
Sbjct: 841 LRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVT 900
Query: 901 LISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSG 960
LISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSG
Sbjct: 901 LISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSG 960
Query: 961 LAFASHV 967
LAFASHV
Sbjct: 961 LAFASHV 967
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 1804 bits (4672), Expect = 0.0
Identities = 896/896 (100%), Positives = 896/896 (100%)
Query: 72 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 131
DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
Query: 132 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 191
EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM
Sbjct: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
Query: 192 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 251
TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
Query: 252 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 311
AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS
Sbjct: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
Query: 312 LNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH 371
LNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH
Sbjct: 260 LNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH 319
Query: 372 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD 431
RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD
Sbjct: 320 RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD 379
Query: 432 NQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKA 491
NQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKA
Sbjct: 380 NQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKA 439
Query: 492 SGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGP 551
SGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGP
Sbjct: 440 SGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGP 499
Query: 552 FKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLT 611
FKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLT
Sbjct: 500 FKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLT 559
Query: 612 GISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV 671
GISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV
Sbjct: 560 GISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSV 619
Query: 672 SCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALG 731
SCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALG
Sbjct: 620 SCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALG 679
Query: 732 FTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAF 791
FTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAF
Sbjct: 680 FTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAF 739
Query: 792 LSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPL 851
LSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPL
Sbjct: 740 LSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPL 799
Query: 852 AYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPR 911
AYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPR
Sbjct: 800 AYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPR 859
Query: 912 LEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV 967
LEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV
Sbjct: 860 LEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV 915
Score = 96.7 bits (239), Expect = 9e-20
Identities = 82/296 (27%), Positives = 138/296 (46%), Gaps = 10/296 (3%)
Query: 188 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 247
+ A L++N ++ + F +L L L L N + H+ +F GL++L+ L L N+L
Sbjct: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
Query: 248 EFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 306
P A+ L LQ L N I +PE++F G L+ + DN + + A LP
Sbjct: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
Query: 307 LH--TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
L TL+LN I ++ + TSL +L L I+ L + + L L L+L++N++
Sbjct: 136 LQAMTLALNRISHIPDYA-FQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 194
Query: 365 EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 423
+E P ++ +L+E+G +N I I F LQ + N I+ + AF L
Sbjct: 195 QEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 254
Query: 424 LVKLDLTDNQLTTLPLAGLGGLMHLKL----KGNLALSQAFSKDSFPKLRILEVPY 475
L L L + + L G L++ + + L + P+LR+LE+ +
Sbjct: 255 LHTLSL-NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309
Score = 96.3 bits (238), Expect = 1e-19
Identities = 82/298 (27%), Positives = 138/298 (46%), Gaps = 10/298 (3%)
Query: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125
P + L++N ++ + F +L L L L N + H+ +F GL++L+ L L N+
Sbjct: 134 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 193
Query: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 185
L P A+ L LQ L N I +PE++F G L+ + DN + + A L
Sbjct: 194 LQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 252
Query: 186 PALQAMTLALNRISHIPDYA-FQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYN 244
P L TL+LN I ++ + TSL +L L I+ L + + L L L+L++N
Sbjct: 253 PKLH--TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHN 310
Query: 245 KLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 304
+++E P ++ +L+E+G +N I I F LQ + N I+ + AF L
Sbjct: 311 QIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 369
Query: 305 PKLHTLSL-NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 361
L L L + + L G L++ + + L + P+LR+LE+ +
Sbjct: 370 HSLVKLDLTDNQLTTLPLAGLGGLMHLKL----KGNLALSQAFSKDSFPKLRILEVPY 423
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 1510 bits (3909), Expect = 0.0
Identities = 753/799 (94%), Positives = 768/799 (96%)
Query: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228
L N LTE+ ++L L+ + L+ N +SHIP AF L SL +L L NN++ +
Sbjct: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
Query: 229 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288
+ L +L++LDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF
Sbjct: 90 ALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 149
Query: 289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 348
YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC
Sbjct: 150 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
Query: 349 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408
QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN
Sbjct: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
Query: 409 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 468
AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL
Sbjct: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
Query: 469 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 528
RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD
Sbjct: 330 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 389
Query: 529 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 588
ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA
Sbjct: 390 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 449
Query: 589 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 648
GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL
Sbjct: 450 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 509
Query: 649 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 708
AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV
Sbjct: 510 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 569
Query: 709 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 768
GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD
Sbjct: 570 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWD 629
Query: 769 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 828
CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL
Sbjct: 630 CAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYL 689
Query: 829 LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP 888
LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP
Sbjct: 690 LFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP 749
Query: 889 PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG 948
PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG
Sbjct: 750 PGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGG 809
Query: 949 GLSGGGGFQPSGLAFASHV 967
GLSGGGGFQPSGLAFASHV
Sbjct: 810 GLSGGGGFQPSGLAFASHV 828
Score = 39.7 bits (91), Expect = 0.014
Identities = 30/79 (37%), Positives = 40/79 (50%), Gaps = 3/79 (3%)
Query: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
+ L N + E+ F L L+ L LS N + I +AFS L+SL L L +NQL +P
Sbjct: 240 IGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
Query: 131 AEALWELPSLQSLRLDANL 149
L L L L+L NL
Sbjct: 300 ---LAGLGGLMHLKLKGNL 315
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 970 bits (2507), Expect = 0.0
Identities = 495/893 (55%), Positives = 634/893 (70%), Gaps = 19/893 (2%)
Query: 23 GGAPQPGPGPTACPAPCHCQEDG-IMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTEL 81
G +P+ G CP CHC+ DG ++L DCS+LGLS +P +L T+YLDLSMNN+++L
Sbjct: 22 GSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQL 81
Query: 82 QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQ 141
P LRFLEELRL+GN L++IP AF+GLYSLK+LMLQNNQL +P EAL L SLQ
Sbjct: 82 LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQ 141
Query: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI 201
SLRLDAN IS VP F GL SLRHLWLDDNALTEIPV+A +L ALQAMTLALN+I HI
Sbjct: 142 SLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHI 201
Query: 202 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQE 261
PDYAF NL+SLVVLHLHNNRI LG F+GLH+LETLDLNYN L EFP AIRTL L+E
Sbjct: 202 PDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKE 261
Query: 262 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEF 321
LGFH+NNI++IPEKAF+GNP L TIHFYDNPIQFVGRSAFQ+LP+L TL+LNGA I EF
Sbjct: 262 LGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEF 321
Query: 322 PDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGL 381
PDL GT +LE LTLT A I LP +C QLP L+VL+LS+N +E+LPS CQKL++I L
Sbjct: 322 PDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDL 381
Query: 382 QHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAG 441
+HN I+EI DTF QL SL++L+L+WN I IHP AFSTL SL+KLDL+ N L++ P+ G
Sbjct: 382 RHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITG 441
Query: 442 LGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLH 501
L GL HLKL GN AL S ++FP+L+++E+PYAYQCC +G+C + +K S QW D +
Sbjct: 442 LHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGD-N 500
Query: 502 LDDEESSKRPLGLLARQAENHYDQDLDELQLEM-EDSKPHPSVQCSPTPGPFKPCEYLFE 560
++ K+ G+ Q E +DL++ L+ ED K SVQCSP+PGPFKPCE+L +
Sbjct: 501 SSMDDLHKKDAGMFQAQDE----RDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLD 556
Query: 561 SWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLAS 620
W IR+ VW I +L++ CN LV TVF P+ + P+K ++G IA N LTG+S +LA
Sbjct: 557 GWLIRIGVWTIAVLALTCNALVTSTVFR-SPLYISPIKLLIGVIAAVNMLTGVSSAVLAG 615
Query: 621 VDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKS 680
VDA TFG F+ +GA WE G+GC GFL++ SE+SV LLTLAA++ SV +
Sbjct: 616 VDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETK 675
Query: 681 PSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMN 740
S++ +L C LA AA+PL +YGASPLCLP P G+P+ +G+ VAL+++N
Sbjct: 676 APFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPL--PFGEPSTMGYMVALILLN 733
Query: 741 SFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGL 800
S CFL++ AY KLYC+L +GD E +WDC+MV+H+A L+F + +L CPVAFLSF+S++ L
Sbjct: 734 SLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINL 793
Query: 801 FPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRA-----GDSGPLAYAA 855
++PE +K +LLVV+PLPACLNPLLY+LFNPHF++DL LR + L
Sbjct: 794 TFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSIN 853
Query: 856 AGELEKSSCDSTQALVAFSDVDLILEASEAGRP----PGLETYGFPSVTLISC 904
+ ++EK SCDSTQALV F+ + + + P P E+ SV + C
Sbjct: 854 SDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSSVAFVPC 906
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 776 bits (2004), Expect = 0.0
Identities = 431/918 (46%), Positives = 561/918 (61%), Gaps = 37/918 (4%)
Query: 1 MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAV 60
MP P GL LC A G A G P C APC C D DCS GL+AV
Sbjct: 1 MPGPLGL----LC--FLALGLLGSAGPSGAAPPLCAAPCSCDGDR---RVDCSGKGLTAV 51
Query: 61 PGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM 120
P L T LD+SMNN+T+L F + FLEEL+L+GN LS I +A SGL LK+L
Sbjct: 52 PEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLT 111
Query: 121 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR 180
LQNNQL +P+EA+ L +LQSLRLDAN I+ VPE SFEGL LRHLWLDDN+LTE+PV
Sbjct: 112 LQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVH 171
Query: 181 ALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLD 240
L+NLP LQA+TLALN+IS IPD+AF NL+SLVVLHLHNN+I+ L H F+GL NLETLD
Sbjct: 172 PLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLD 231
Query: 241 LNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA 300
LNYN L EFP AI+ L L+ELGFH+N+I IP+ AF GNPLL+TIH YDNP+ FVG SA
Sbjct: 232 LNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291
Query: 301 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
F L LH+L + GA +Q+FP+L GT LE LTLT I +P+ +CQ+ LR L+LS
Sbjct: 292 FHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLS 351
Query: 361 HNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420
+N I +LPS + C LEEI LQ N+I++I TF L SL+ LDLS N I IH AF+T
Sbjct: 352 YNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411
Query: 421 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
L + LD++ N+LT+ P GL GL LKL GN L +A + F LR L VPYAYQCC
Sbjct: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCC 471
Query: 481 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPH 540
+ C S+ + + + H +E + EN +
Sbjct: 472 AFWGCDSYANLNTEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQI------------- 518
Query: 541 PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFV 600
+ C+P+ G FKPCEYL SW IRL VW I L+++ N LV+LT FA LP K
Sbjct: 519 -IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFA-SCTSLPSSKLF 576
Query: 601 VGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLL 660
+G I+ +N GI G+L +DA+++G+F+E+G WETG GC+ GFLAV SE+++ LL
Sbjct: 577 IGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLL 636
Query: 661 TLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY 720
LA V+ S+S + GKS L R L A +A PL GEY ASPLCLP+
Sbjct: 637 MLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPF 696
Query: 721 APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIF 780
P G+ +LGFTV LV++NS FL++A Y KLYC+L + D +M++HVAWLIF
Sbjct: 697 --PTGETPSLGFTVTLVLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIF 754
Query: 781 ADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDD--- 837
+ + +CPVAF SFA ++ ++PE +KSV L+ PLPACLNP+LY+ FNP F++D
Sbjct: 755 TNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKL 814
Query: 838 -LRRLRPRAGDSGPLAYAAAGELEKS---SCDSTQALVAFSDVDLILEASEAGRPPG--- 890
RR+ ++G + G LE+ C L V E+ +P
Sbjct: 815 LKRRVTKKSGSVSVSISSQGGCLEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKH 874
Query: 891 -LETYGFPSVTLISCQQP 907
++++ P++ + SCQ+P
Sbjct: 875 LIKSHSCPALAVASCQRP 892
>gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 695
Score = 174 bits (442), Expect = 3e-43
Identities = 154/634 (24%), Positives = 277/634 (43%), Gaps = 49/634 (7%)
Query: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 319
EL F ++ I + AF G L+ I N + + + F LPKLH + + A ++
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLL 109
Query: 320 EF-PD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLE 377
P+ + +L+ L ++ GI+ LP + ++ L+ I++ ++H ++
Sbjct: 110 YINPEAFQNLPNLQYLLISNTGIKHLPD-----VHKIHSLQKVLLDIQDNINIHTIERNS 164
Query: 378 EIGLQH---------NRIWEIGADTFSQLSSLQALDLSWNA-IRSIHPEAFSTLHSLVKL 427
+GL N I EI F+ + L L+LS N + + + F V L
Sbjct: 165 FVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDELNLSDNNNLEELPNDVFHGASGPVIL 223
Query: 428 DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCAS 487
D++ ++ +LP GL L L+ + L + + + L + Y CC +
Sbjct: 224 DISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAF----- 278
Query: 488 FFKASGQWEAEDLH-----------LDDEESSKRPLGLLARQAENHYDQDLDELQLEMED 536
A+ + + +LH +D ++ LA E+ Y + D E +
Sbjct: 279 ---ANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDY 335
Query: 537 SKPHP--SVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPL 594
+ V CSP P F PCE + +R+ +W I +L++ N +++L + L
Sbjct: 336 DLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKL 394
Query: 595 PPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSE 654
+F++ +A A+ GI L+ASVD T Q+ Y W+TG GC A GF V SE
Sbjct: 395 TVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASE 454
Query: 655 ASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGAS 714
SV LT ++ +++ L + ++ A AA P+ + Y
Sbjct: 455 LSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKV 514
Query: 715 PLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVR 773
+CLP P + + ++L+++N F+V+ G YI +Y + + + D + +
Sbjct: 515 SICLPM--DIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAK 572
Query: 774 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH 833
+A LIF D L P++F + ++ L + +T K +L++ P+ +C NP LY +F +
Sbjct: 573 RMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKN 632
Query: 834 FRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDST 867
FR D L + G Y ++ ++ ST
Sbjct: 633 FRRDFFILLSKCG-----CYEMQAQIYRTETSST 661
Score = 58.9 bits (141), Expect = 2e-08
Identities = 58/229 (25%), Positives = 98/229 (42%), Gaps = 38/229 (16%)
Query: 39 CHCQEDGIMLSADCSELGLSAVPGDLDPLTAY-------------------------LDL 73
CHC + C E ++ +P DL P A +++
Sbjct: 23 CHCSNRVFL----CQESKVTEIPSDL-PRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEI 77
Query: 74 SMNNLTE-LQPGLFHHLRFLEELRL-SGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 131
S N++ E ++ +F +L L E+R+ N+L +I +AF L +L+ L++ N + +P
Sbjct: 78 SQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLP- 136
Query: 132 EALWELPSLQSLRLDAN---LISLVPERSFEGLS-SLRHLWLDDNALTEIPVRALNNLPA 187
+ ++ SLQ + LD I + SF GLS LWL+ N + EI A N
Sbjct: 137 -DVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQL 195
Query: 188 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNL 236
+ N + +P+ F + V+L + RI L ++ E L L
Sbjct: 196 DELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKL 244
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 167 bits (423), Expect = 4e-41
Identities = 143/440 (32%), Positives = 206/440 (46%), Gaps = 12/440 (2%)
Query: 24 GAPQPGPGPTACPAPCHCQ--EDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTEL 81
G P GP ACPA C C +D LS CS L+ +P + T L L NNL+ +
Sbjct: 69 GTPGEAEGP-ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 127
Query: 82 QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQ 141
P F +L L L L G L + QA GL +L L L+ NQL + P+L
Sbjct: 128 PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 187
Query: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI 201
SL L N +S + + FEGL SL L L N+L +P A L +L+ + LA NR++++
Sbjct: 188 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 247
Query: 202 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQ 260
F L L L L N ++ + + F L L+ L L+ N + P A L L+
Sbjct: 248 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 307
Query: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE 320
L +N + + E F G L+ + N I + F+ L L L L G I++
Sbjct: 308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQL-GHNRIRQ 366
Query: 321 FPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKL 376
+ +G LE+LTL ++ + +G L + V+ LS N + LP KL
Sbjct: 367 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 426
Query: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 436
+ L+ + + I TF+ LS L+ L L N + I ++ L L++LDLT NQLT
Sbjct: 427 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH 486
Query: 437 LP---LAGLGGLMHLKLKGN 453
LP GLG L +L L N
Sbjct: 487 LPHRLFQGLGKLEYLLLSRN 506
Score = 154 bits (388), Expect = 5e-37
Identities = 119/351 (33%), Positives = 174/351 (49%), Gaps = 6/351 (1%)
Query: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
L+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
Query: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
A +LP LQ L LD NLI+ V +F GL +LR L L N + + L L+
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
Query: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
+ L+ N I+ + F++L L L L +NRI+ L SFEGL LE L L++N+LQE
Sbjct: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
Query: 251 V-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
A L + + N ++ +PE+ F G L ++H + + + F L L
Sbjct: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 452
Query: 310 LSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 367
L L NG + I+E L G L L LT + LP + Q L +L L LS N++ EL
Sbjct: 453 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 511
Query: 368 P--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
P +L Q+ + + HNR+ + + L L+ L L N++R+ P+
Sbjct: 512 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 562
Score = 150 bits (380), Expect = 4e-36
Identities = 124/394 (31%), Positives = 189/394 (47%), Gaps = 9/394 (2%)
Query: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125
P A L LS N L+ L+ GLF L L +L L N L+ +P AF GL SL+ L+L N+
Sbjct: 184 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR 243
Query: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 185
L + L L+ L L N + + F L L+ L+LD N + + A L
Sbjct: 244 LAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGL 303
Query: 186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 245
AL+ + L+ NR++ + + F L L VL L +N I L +F+ LH LE L L +N+
Sbjct: 304 KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNR 363
Query: 246 LQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 304
+++ + LG+L+ L +N ++ + AF+G + ++ N ++ + F+ L
Sbjct: 364 IRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL 423
Query: 305 PKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 363
KLH+L L G+ + P G + L L L G+ + L L L+L+ NQ
Sbjct: 424 GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQ 483
Query: 364 IEELPSLHRC----QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 419
+ LP HR KLE + L NR+ E+ AD L LD+S N + ++ +
Sbjct: 484 LTHLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 541
Query: 420 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453
L L L L +N L T GL L L+GN
Sbjct: 542 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 574
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 167 bits (423), Expect = 4e-41
Identities = 143/440 (32%), Positives = 206/440 (46%), Gaps = 12/440 (2%)
Query: 24 GAPQPGPGPTACPAPCHCQ--EDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTEL 81
G P GP ACPA C C +D LS CS L+ +P + T L L NNL+ +
Sbjct: 31 GTPGEAEGP-ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 89
Query: 82 QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQ 141
P F +L L L L G L + QA GL +L L L+ NQL + P+L
Sbjct: 90 PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 149
Query: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI 201
SL L N +S + + FEGL SL L L N+L +P A L +L+ + LA NR++++
Sbjct: 150 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 209
Query: 202 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQ 260
F L L L L N ++ + + F L L+ L L+ N + P A L L+
Sbjct: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 269
Query: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE 320
L +N + + E F G L+ + N I + F+ L L L L G I++
Sbjct: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQL-GHNRIRQ 328
Query: 321 FPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKL 376
+ +G LE+LTL ++ + +G L + V+ LS N + LP KL
Sbjct: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 388
Query: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 436
+ L+ + + I TF+ LS L+ L L N + I ++ L L++LDLT NQLT
Sbjct: 389 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH 448
Query: 437 LP---LAGLGGLMHLKLKGN 453
LP GLG L +L L N
Sbjct: 449 LPHRLFQGLGKLEYLLLSRN 468
Score = 154 bits (388), Expect = 5e-37
Identities = 119/351 (33%), Positives = 174/351 (49%), Gaps = 6/351 (1%)
Query: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
L+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
Query: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
A +LP LQ L LD NLI+ V +F GL +LR L L N + + L L+
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
Query: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
+ L+ N I+ + F++L L L L +NRI+ L SFEGL LE L L++N+LQE
Sbjct: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
Query: 251 V-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
A L + + N ++ +PE+ F G L ++H + + + F L L
Sbjct: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
Query: 310 LSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 367
L L NG + I+E L G L L LT + LP + Q L +L L LS N++ EL
Sbjct: 415 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 473
Query: 368 P--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
P +L Q+ + + HNR+ + + L L+ L L N++R+ P+
Sbjct: 474 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 524
Score = 150 bits (380), Expect = 4e-36
Identities = 124/394 (31%), Positives = 189/394 (47%), Gaps = 9/394 (2%)
Query: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125
P A L LS N L+ L+ GLF L L +L L N L+ +P AF GL SL+ L+L N+
Sbjct: 146 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR 205
Query: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 185
L + L L+ L L N + + F L L+ L+LD N + + A L
Sbjct: 206 LAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGL 265
Query: 186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 245
AL+ + L+ NR++ + + F L L VL L +N I L +F+ LH LE L L +N+
Sbjct: 266 KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNR 325
Query: 246 LQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 304
+++ + LG+L+ L +N ++ + AF+G + ++ N ++ + F+ L
Sbjct: 326 IRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL 385
Query: 305 PKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 363
KLH+L L G+ + P G + L L L G+ + L L L+L+ NQ
Sbjct: 386 GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQ 445
Query: 364 IEELPSLHRC----QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 419
+ LP HR KLE + L NR+ E+ AD L LD+S N + ++ +
Sbjct: 446 LTHLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 503
Query: 420 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453
L L L L +N L T GL L L+GN
Sbjct: 504 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 165 bits (418), Expect = 2e-40
Identities = 124/403 (30%), Positives = 187/403 (46%), Gaps = 9/403 (2%)
Query: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94
CP+ C C +C+ + AVP L L + ++TEL F ++ L
Sbjct: 31 CPSECTCSRAS---QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIA 87
Query: 95 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 154
LR+ N LS I AF L SL+ L L NN+L +P L SL+SL L +N + +
Sbjct: 88 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 147
Query: 155 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 214
F S+L+ L L N L IP A ++L L + L N ++HI FQ+L +L V
Sbjct: 148 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 207
Query: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIP 273
L L+ NR+ + +F+GL NL+ L L N++ P LQ L NN+I +P
Sbjct: 208 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 267
Query: 274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLE 331
FM P L + + N ++ + F +P L L L I PD L+
Sbjct: 268 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDNVFSNLRQLQ 326
Query: 332 ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEI 389
+L L+R I + G L LR L L N +++L L+ I LQ+NR+ ++
Sbjct: 327 VLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQL 386
Query: 390 GADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 432
+ F+ ++ L A+ L N + ++ F L L +L L DN
Sbjct: 387 PGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Score = 68.2 bits (165), Expect = 4e-11
Identities = 46/132 (34%), Positives = 69/132 (52%), Gaps = 5/132 (3%)
Query: 329 SLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH--RCQKLEEIGLQHNRI 386
SL L+L +++LP G+ Q L L L LS NQ+ ++ H +C L+E+ L N +
Sbjct: 108 SLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHL 167
Query: 387 WEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLM 446
I F L L L+L N++ I P F L +L L L +N+LT +P+ GL+
Sbjct: 168 EYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLV 227
Query: 447 HLKLKGNLALSQ 458
+L+ LAL Q
Sbjct: 228 NLQ---ELALQQ 236
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 165 bits (418), Expect = 2e-40
Identities = 124/403 (30%), Positives = 187/403 (46%), Gaps = 9/403 (2%)
Query: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94
CP+ C C +C+ + AVP L L + ++TEL F ++ L
Sbjct: 25 CPSECTCSRAS---QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIA 81
Query: 95 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 154
LR+ N LS I AF L SL+ L L NN+L +P L SL+SL L +N + +
Sbjct: 82 LRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQ 141
Query: 155 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 214
F S+L+ L L N L IP A ++L L + L N ++HI FQ+L +L V
Sbjct: 142 PAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQV 201
Query: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIP 273
L L+ NR+ + +F+GL NL+ L L N++ P LQ L NN+I +P
Sbjct: 202 LRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLP 261
Query: 274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLE 331
FM P L + + N ++ + F +P L L L I PD L+
Sbjct: 262 PSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYD-NHISSLPDNVFSNLRQLQ 320
Query: 332 ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEI 389
+L L+R I + G L LR L L N +++L L+ I LQ+NR+ ++
Sbjct: 321 VLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQL 380
Query: 390 GADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 432
+ F+ ++ L A+ L N + ++ F L L +L L DN
Sbjct: 381 PGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Score = 68.2 bits (165), Expect = 4e-11
Identities = 46/132 (34%), Positives = 69/132 (52%), Gaps = 5/132 (3%)
Query: 329 SLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH--RCQKLEEIGLQHNRI 386
SL L+L +++LP G+ Q L L L LS NQ+ ++ H +C L+E+ L N +
Sbjct: 102 SLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHL 161
Query: 387 WEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLM 446
I F L L L+L N++ I P F L +L L L +N+LT +P+ GL+
Sbjct: 162 EYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLV 221
Query: 447 HLKLKGNLALSQ 458
+L+ LAL Q
Sbjct: 222 NLQ---ELALQQ 230
>gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 633
Score = 165 bits (417), Expect = 2e-40
Identities = 165/614 (26%), Positives = 268/614 (43%), Gaps = 71/614 (11%)
Query: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI-QFVGRSAFQYLPKLHTLSLNGAMDIQ 319
EL F ++ I + AF G L+ I N + + + F LPKLH + + A ++
Sbjct: 50 ELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNL- 108
Query: 320 EFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEI 379
+ + P Q LP L+ L +S+ I+ LP +H+ L+++
Sbjct: 109 --------------------LYINPEAF-QNLPNLQYLLISNTGIKHLPDVHKIHSLQKV 147
Query: 380 --GLQHN-RIWEIGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTD-NQL 434
+Q N I I ++F LS L L+ N I+ IH AF+ L +L+L+D N L
Sbjct: 148 LLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNL 206
Query: 435 TTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQ 494
LP G G + LS+ + LR EV Y Q A GQ
Sbjct: 207 EELPNDVFHG-----ASGPVILSELHPICNKSILR-QEVDYMTQ------------ARGQ 248
Query: 495 WEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKP 554
L D+E S R + +D DL E+ D V CSP P F P
Sbjct: 249 --RSSLAEDNESSYSRGFDM----TYTEFDYDLCN---EVVD------VTCSPKPDAFNP 293
Query: 555 CEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGIS 614
CE + +R+ +W I +L++ N +++L + L +F++ +A A+ GI
Sbjct: 294 CEDIMGYNILRVLIWFISILAITGN-IIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 352
Query: 615 CGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCV 674
L+ASVD T Q+ Y W+TG GC A GF V SE SV LT ++ +++
Sbjct: 353 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 412
Query: 675 RAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTV 734
L + ++ A AA P+ + Y +CLP P + + +
Sbjct: 413 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPM--DIDSPLSQLYVM 470
Query: 735 ALVMMNSFCFLVVAGAYIKLYCDLPRGDF-EAVWDCAMVRHVAWLIFADGLLYCPVAFLS 793
+L+++N F+V+ G YI +Y + + + D + + +A LIF D L P++F +
Sbjct: 471 SLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFA 530
Query: 794 FASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAY 853
++ L + +T K +L++ P+ +C NP LY +F +FR D L + G Y
Sbjct: 531 ISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCG-----CY 585
Query: 854 AAAGELEKSSCDST 867
++ ++ ST
Sbjct: 586 EMQAQIYRTETSST 599
Score = 55.5 bits (132), Expect = 2e-07
Identities = 62/246 (25%), Positives = 93/246 (37%), Gaps = 57/246 (23%)
Query: 39 CHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLS 98
CHC + C E ++ +P DL L + L +Q G F LE++ +S
Sbjct: 23 CHCSNRVFL----CQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEIS 78
Query: 99 GNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDA--NLISLVPER 156
QN+ L I A+ LP L +R++ NL+ + PE
Sbjct: 79 -----------------------QNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPE- 114
Query: 157 SFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLH 216
A NLP LQ + ++ I H+PD + V+L
Sbjct: 115 ------------------------AFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLD 150
Query: 217 LHNN-RIQHLGTHSFEGL-HNLETLDLNYNKLQEFPVAIRTLGRLQELGF-HNNNIKAIP 273
+ +N I + +SF GL L LN N +QE +L EL NNN++ +P
Sbjct: 151 IQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELP 210
Query: 274 EKAFMG 279
F G
Sbjct: 211 NDVFHG 216
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 165 bits (417), Expect = 2e-40
Identities = 156/520 (30%), Positives = 217/520 (41%), Gaps = 84/520 (16%)
Query: 5 PGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDL 64
P L LWL A P+ C A C C D S DC GL+A+PGDL
Sbjct: 16 PCLLLLWLLLLRLEPVTAAAGPR-----APCAAACTCAGD----SLDCGGRGLAALPGDL 66
Query: 65 DPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIP------------------ 106
T L+LS N L+E+ P F L L+E+ L+ N L+ +P
Sbjct: 67 PSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNK 126
Query: 107 -----GQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL 161
G SL++L L N + + P ++ L L N I + +F+GL
Sbjct: 127 IRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGL 186
Query: 162 S-SLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN 220
S SL L L N +T++PVRA LP L + L NRI I FQ L SL VL L N
Sbjct: 187 SRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRN 245
Query: 221 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN 280
I L +F GL + L L YN L E + + G
Sbjct: 246 NISKLTDGAFWGLSKMHVLHLEYNSLVE-----------------------VNSGSLYGL 282
Query: 281 PLLQTIHFYDNPIQFVGRSAFQYLPKLH--TLSLNGAMDIQEFPDLKGTTSLEILTLTRA 338
L +H +N I + R + + KLH LS N + E L +SL +L L+
Sbjct: 283 TALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDE-ESLAELSSLSVLRLSHN 341
Query: 339 GIRLLPSGMCQQLPRLRVLELSHNQI-----EELPSLHRCQKLEEIGLQHNRIWEIGADT 393
I + G + L LRVL+L HN+I + + L ++ L N+I +
Sbjct: 342 SISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRA 401
Query: 394 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLD------LTDNQLTTLPLAGLGGLMH 447
FS L L+ L+L NAIRS+ +AF + +L +L L D QL LP +G ++
Sbjct: 402 FSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQ 461
Query: 448 L----------KLKGNLALS---QAFSKDSFPKLRILEVP 474
LKG S ++F D F K +I+ P
Sbjct: 462 AFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQP 501
>gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 764
Score = 151 bits (381), Expect = 3e-36
Identities = 174/727 (23%), Positives = 306/727 (42%), Gaps = 62/727 (8%)
Query: 186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN-RIQHLGTHSFEGLHNLETLDLNYN 244
P+ Q + L + IP +AF NL ++ +++ + +Q L +HSF L + +++
Sbjct: 52 PSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNT 111
Query: 245 KLQEF--PVAIRTLGRLQELGFHNNNIKAIPEKAFM-GNPLLQTIHFYDNP-IQFVGRSA 300
+ + P A++ L L+ LG N +K P+ + + + DNP + + +A
Sbjct: 112 RNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNA 171
Query: 301 FQYLPKLHTLSL----NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS---GMCQQLPR 353
FQ L TL+L NG +Q + GT + + ++ G P
Sbjct: 172 FQGLCN-ETLTLKLYNNGFTSVQGYA-FNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPS 229
Query: 354 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFS-QLSSLQALDLSWNAIRS 412
L L++S + LPS + L+E+ ++ W + S L DLS+ +
Sbjct: 230 L--LDVSQTSVTALPS-KGLEHLKELIARNT--WTLKKLPLSLSFLHLTRADLSYPSHCC 284
Query: 413 IHPEAFSTLHSLVKLDLTDNQLTTL----PLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 468
L L ++ + +L + L +H + + NL S K+
Sbjct: 285 AFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQ 344
Query: 469 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 528
+ Y FF+ E ED + + K P + ++HYD +
Sbjct: 345 DTHNNAHYYV---------FFE-----EQEDEIIGFGQELKNPQEETLQAFDSHYDYTI- 389
Query: 529 ELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFA 588
DS+ + C+P F PCE + +R+ VW + LL++L N VLL +
Sbjct: 390 -----CGDSE---DMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLT 441
Query: 589 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 648
L +F++ +A A+ G+ L+ASVD T ++ + W+TG GC GF
Sbjct: 442 SH-YKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFF 500
Query: 649 AVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASV 708
V SE SV LT+ ++ +++ + L A ++G L A LPL +
Sbjct: 501 TVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGI 560
Query: 709 GEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFE-AVW 767
Y +CLP P AL + V ++ +N F++V Y+K+Y + +
Sbjct: 561 SSYAKVSICLPM--DTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDK 618
Query: 768 DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLY 827
D + + +A LIF D + P++F + +++L +T K +L++ PL +C NP LY
Sbjct: 619 DTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLY 678
Query: 828 LLFNPHFRDDLRRLRPRAGDSGPLAYAAAG-----------ELEKSSCDSTQALVAFSDV 876
+F F+ D+ L + G A A G +++K + + Q L DV
Sbjct: 679 AIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHEMRQGLHNMEDV 738
Query: 877 DLILEAS 883
++E S
Sbjct: 739 YELIENS 745
Score = 38.9 bits (89), Expect = 0.023
Identities = 55/253 (21%), Positives = 103/253 (40%), Gaps = 18/253 (7%)
Query: 247 QEFPVAIRTLGRL-------QELGFHNNNIKAIPEKAFMGNPLLQTIHF-YDNPIQFVGR 298
++F V + + R+ Q L +++ IP AF P + I+ D +Q +
Sbjct: 35 EDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLES 94
Query: 299 SAFQYLPKLHTLSLNGAMDIQEF-PD-LKGTTSLEILTLTRAGIRLLPS-GMCQQLPRLR 355
+F L K+ + + ++ PD LK L+ L + G+++ P
Sbjct: 95 HSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFF 154
Query: 356 VLELSHNQIEELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNA-I 410
+LE++ N ++ C + + L +N + F+ + L A+ L+ N +
Sbjct: 155 ILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNG-TKLDAVYLNKNKYL 213
Query: 411 RSIHPEAFSTLHSLVKL-DLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLR 469
I +AF ++S L D++ +T LP GL L L + L + SF L
Sbjct: 214 TVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLT 273
Query: 470 ILEVPYAYQCCPY 482
++ Y CC +
Sbjct: 274 RADLSYPSHCCAF 286
Score = 33.5 bits (75), Expect = 0.99
Identities = 53/213 (24%), Positives = 92/213 (43%), Gaps = 35/213 (16%)
Query: 93 EELRLSGNHLSHIPGQAFSGL----------------------YSLK----ILMLQNNQL 126
+ L+L HL IP AFS L Y+L I + L
Sbjct: 55 QTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNL 114
Query: 127 GGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLW--LDDNALTEIPVRALNN 184
I +AL ELP L+ L + + + P+ + + + + D+ +T IPV A
Sbjct: 115 TYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQG 174
Query: 185 LPALQAMTLAL--NRISHIPDYAFQNLTSLVVLHLHNNR-IQHLGTHSFEGLHNLETLDL 241
L + +TL L N + + YAF N T L ++L+ N+ + + +F G+++ +L L
Sbjct: 175 L-CNETLTLKLYNNGFTSVQGYAF-NGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSL-L 231
Query: 242 NYNKLQEFPVAIRTLGRLQELGFHNN-NIKAIP 273
+ ++ + + L L+EL N +K +P
Sbjct: 232 DVSQTSVTALPSKGLEHLKELIARNTWTLKKLP 264
>gi|106067657 luteinizing hormone/choriogonadotropin receptor
precursor [Homo sapiens]
Length = 699
Score = 147 bits (371), Expect = 5e-35
Identities = 134/553 (24%), Positives = 234/553 (42%), Gaps = 49/553 (8%)
Query: 331 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHR------------CQKLE- 377
EIL +R + G LPRL+ L + + I + P + + C L
Sbjct: 102 EILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHI 161
Query: 378 ----------------EIGLQHNRIWEIGADTFSQLSSLQALDLSWNA-IRSIHPEAFST 420
+ L N E+ + F+ ++L +L+L N + +H AF
Sbjct: 162 TTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNG-TTLTSLELKENVHLEKMHNGAFRG 220
Query: 421 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
LD++ +L LP GL + L + +L + S+++F L + Y CC
Sbjct: 221 ATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCC 280
Query: 481 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENH--YDQDLDELQLEMEDSK 538
F+ E H E SK+ + R+ N Y L E +L D +
Sbjct: 281 A-------FRNLPTKEQNFSHSISENFSKQCESTV-RKVNNKTLYSSMLAESELSGWDYE 332
Query: 539 PH----PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPL 594
+ +C+P P F PCE + +R+ +W I +L+++ N + +L V L
Sbjct: 333 YGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGN-MTVLFVLLTSRYKL 391
Query: 595 PPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSE 654
+F++ ++ A+ G+ L+ASVD+ T GQ+ + W+TG GC GF V SE
Sbjct: 392 TVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASE 451
Query: 655 ASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGAS 714
SV LT+ ++ +++ + L +LG + L A LPL V Y
Sbjct: 452 LSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKV 511
Query: 715 PLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAV-WDCAMVR 773
+C P + + + ++++N F ++ YIK+Y + + A D + +
Sbjct: 512 SICFPM--DVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAK 569
Query: 774 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH 833
+A LIF D P++F + ++ + +T K +L++ P+ +C NP LY +F
Sbjct: 570 KMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKT 629
Query: 834 FRDDLRRLRPRAG 846
F+ D L + G
Sbjct: 630 FQRDFFLLLSKFG 642
Score = 56.2 bits (134), Expect = 1e-07
Identities = 67/265 (25%), Positives = 117/265 (44%), Gaps = 30/265 (11%)
Query: 35 CPAPCHCQEDGIML----SADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR 90
CP PC+C DG + +A + L L+ +P + P A+ L N + +++
Sbjct: 30 CPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGL--NEVIKIEISQI---- 83
Query: 91 FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ-LGGIPAEALWELPSLQSLRLDANL 149
+ L I AF L +L +++QN + L I A LP L+ L +
Sbjct: 84 ---------DSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTG 134
Query: 150 ISLVPE--RSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLAL--NRISHIPDYA 205
I P+ + F S+ D+ +T IP A + +++TL L N + +A
Sbjct: 135 IRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNN-ESVTLKLYGNGFEEVQSHA 193
Query: 206 FQNLTSLVVLHLHNN-RIQHLGTHSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQELG 263
F N T+L L L N ++ + +F G +TLD++ KLQ P + ++ RL +
Sbjct: 194 F-NGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRL--IA 250
Query: 264 FHNNNIKAIPEKAFMGNPLLQTIHF 288
+ ++K +P + N L T+ +
Sbjct: 251 TSSYSLKKLPSRETFVNLLEATLTY 275
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 147 bits (370), Expect = 6e-35
Identities = 139/456 (30%), Positives = 215/456 (47%), Gaps = 35/456 (7%)
Query: 3 SPPGLRA------LWLCAALCASRRAG-------GAPQPGPGPTACPAPCHCQEDGIMLS 49
S P LRA L LCA L + R+ G P CP C C D +
Sbjct: 2 SAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLL--- 58
Query: 50 ADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQA 109
DCS L+ +P L A LDLS N L+ ++ HL+ L E++L+ N L IP
Sbjct: 59 -DCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG 117
Query: 110 FSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWL 169
++ +L L N++ I E L E SL++L L +N IS + + +F L L++L+L
Sbjct: 118 PVSA-NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYL 174
Query: 170 DDNALTEIPVRALNNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228
+ N +T + +NL L + L NRIS IP F+ L L L L+ N+I+++
Sbjct: 175 NSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGL 233
Query: 229 SFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 287
+F+GL L++L + N + + A L ++ L +NN+ I + G +LQ +H
Sbjct: 234 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELH 293
Query: 288 FYDNPIQFVGRSAFQYLPKLHTLSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLL 343
N I + A+++ KL L L +D F G + L L + + +
Sbjct: 294 LSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYI 350
Query: 344 PSGMCQQLPRLRVLELSHNQI----EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLS 398
+ L L+ L+L +N+I E++ + KL + LQ NRI I F+ L
Sbjct: 351 ADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLD 410
Query: 399 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 434
+L+ LDLS NAI S+ AFS + L +L L + L
Sbjct: 411 ALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 85.9 bits (211), Expect = 2e-16
Identities = 83/301 (27%), Positives = 141/301 (46%), Gaps = 14/301 (4%)
Query: 162 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 221
S + L L N L+ I ++++L +L+ + L N + IP+ + ++ +L L NR
Sbjct: 74 SWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNR 132
Query: 222 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MG 279
I + + +LETLDL+ N + E A L +L+ L ++N + ++ F +
Sbjct: 133 IVEILPEHLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLA 191
Query: 280 NPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL--KGTTSLEILTLTR 337
N LL + N I + F+ LP+L L LN I+ L +G +L+ L + R
Sbjct: 192 NTLL-VLKLNRNRISAIPPKMFK-LPQLQHLELN-RNKIKNVDGLTFQGLGALKSLKMQR 248
Query: 338 AGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFS 395
G+ L G L + +L+L HN + E+ L+ L+E+ L N I I D +
Sbjct: 249 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWE 308
Query: 396 QLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKG 452
L LDL++N + + +F L L L + +N+++ + GL L L LK
Sbjct: 309 FCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKN 368
Query: 453 N 453
N
Sbjct: 369 N 369
Score = 58.5 bits (140), Expect = 3e-08
Identities = 67/247 (27%), Positives = 110/247 (44%), Gaps = 32/247 (12%)
Query: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPE 274
L L +NR+ + S L +L + LN N+L+ P LG + NI +
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL-- 126
Query: 275 KAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEIL 333
+ GN +++ + + FQ L L LS N ++Q FP L+ L+ L
Sbjct: 127 -SLAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYL 172
Query: 334 TLTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGA 391
L + + G L L VL+L+ N+I +P + + +L+ + L N+I +
Sbjct: 173 YLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDG 232
Query: 392 DTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLK 451
TF L +L++L + N + + AF L ++ L L N LT + L GL+ L+
Sbjct: 233 LTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ-- 290
Query: 452 GNLALSQ 458
L LSQ
Sbjct: 291 -ELHLSQ 296
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 146 bits (368), Expect = 1e-34
Identities = 136/441 (30%), Positives = 208/441 (47%), Gaps = 51/441 (11%)
Query: 27 QPGPGPTA--CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPG 84
+PGPGP A CP C C ++G++ DC + L PGDL T +L L N L ++ P
Sbjct: 106 EPGPGPAAVSCPRDCACSQEGVV---DCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPE 162
Query: 85 LFHHLRFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGIPAEALWELP-SLQ 141
L LE L L N L+ +P +AF L +L L L NN+L P LP +L
Sbjct: 163 ELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPR----FLPNALI 218
Query: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE--IPVRALNNLPALQAMTLALNRIS 199
S+ AN ++ + +F +LR ++L +N L + +P N ++ + L+ N +
Sbjct: 219 SVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLR 278
Query: 200 HIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRT---L 256
H+P + +L LHL NN+++ + +F L +L L L N L + + T L
Sbjct: 279 HVPKHL---PPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKL 335
Query: 257 GRLQELGFHNNNIKAIPEKAFMGNP-LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 315
L+ L +NN+ +P G P L +H N I+ V + + L L L+
Sbjct: 336 SSLEYLDLSSNNLSRVP----AGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSN 391
Query: 316 MDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQK 375
L GI L Q L RL + L +N +E +PS ++
Sbjct: 392 Q------------------LREQGIHPL---AFQGLKRLHTVHLYNNALERVPS-GLPRR 429
Query: 376 LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQ 433
+ + + HN+I IG + F+ L+ L+LS+N I S +H +AF L L LDL+ N+
Sbjct: 430 VRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNR 489
Query: 434 LTTLPLAGLGGLMH-LKLKGN 453
L TLP GL +H LK+K N
Sbjct: 490 LHTLP-PGLPRNVHVLKVKRN 509
Score = 78.6 bits (192), Expect = 3e-14
Identities = 81/271 (29%), Positives = 121/271 (44%), Gaps = 18/271 (6%)
Query: 70 YLDLSMNNLTE--LQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL-YSLKILMLQNNQL 126
YL L N L E + P F L+ L + L N L +P SGL ++ LM+ +NQ+
Sbjct: 385 YLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVP----SGLPRRVRTLMILHNQI 440
Query: 127 GGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTEIPVRALNN 184
GI E L+ L L N I+ V +F L LR L L N L +P N
Sbjct: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN 500
Query: 185 LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH--LGTHSFEGLHNLETLDLN 242
+ L+ N ++ + A + L L+L +NR++ LG ++ L +L+ LD+
Sbjct: 501 VHVLKVKR---NELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIA 557
Query: 243 YNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQF--VGRSA 300
N+L E P + L+ L NN I A+P AF P L+ I N + V SA
Sbjct: 558 GNQLTEIPEGLPE--SLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSA 615
Query: 301 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE 331
F+ L L L + G ++ + +G E
Sbjct: 616 FRRLKHLQVLDIEGNLEFGDISKDRGRLGKE 646
Score = 70.1 bits (170), Expect = 1e-11
Identities = 67/219 (30%), Positives = 105/219 (47%), Gaps = 15/219 (6%)
Query: 57 LSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS--HIPGQAFSGLY 114
L VP L L + N +T + F FLEEL LS N ++ + AF L
Sbjct: 419 LERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLR 478
Query: 115 SLKILMLQNNQLGGIPAEALWELP-SLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNA 173
L+ L L N+L +P LP ++ L++ N ++ + + G++ LR L+L N
Sbjct: 479 LLRSLDLSGNRLHTLPPG----LPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNR 534
Query: 174 LTE--IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 231
L + RA +L LQ + +A N+++ IP+ + SL L+L NN+I + ++F+
Sbjct: 535 LRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPE---SLEYLYLQNNKISAVPANAFD 591
Query: 232 GLHNLETLDLNYNKLQEFPV---AIRTLGRLQELGFHNN 267
NL+ + L +NKL V A R L LQ L N
Sbjct: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 140 bits (354), Expect = 4e-33
Identities = 126/410 (30%), Positives = 203/410 (49%), Gaps = 26/410 (6%)
Query: 28 PGPGPTACPAPCHCQEDGIMLSADCSELGLSA-----VPGDLDPLTAYLDLSMNNLTELQ 82
P G CPAPC C+ + DCS L A + G L P TA LD S N L+
Sbjct: 36 PAAGAGLCPAPCSCR----IPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWN 91
Query: 83 PGLFHHLRFLEELRLSGNHLSHIP--GQAFSGLYSLKILMLQNNQLGGIPAEALWELPSL 140
L + L+E++++ N L+ IP G+ S ++ +L L +N + I A+AL P+L
Sbjct: 92 ISL--ESQTLQEVKMNYNELTEIPYFGEPTS---NITLLSLVHNIIPEINAQALQFYPAL 146
Query: 141 QSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA-LQAMTLALNRIS 199
+SL L +N+IS + SF + L++L L +N +T + +NL + L + L NR+S
Sbjct: 147 ESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMS 205
Query: 200 HIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGR 258
IP F+ L L L L NRI+ + +F+GL +L +L + N + + A L
Sbjct: 206 MIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNN 264
Query: 259 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMD 317
++EL +NN+ + + G +LQ ++ N I+ + A+++ +L L L+ +
Sbjct: 265 MEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLT 324
Query: 318 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI-----EELPSLHR 372
+ G + LE L L + + G+ + L L+ L+L +N+I + +
Sbjct: 325 RLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAG 384
Query: 373 CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH 422
L ++ LQ N+I I F L SL+ LDL+ NAI SI AFS H
Sbjct: 385 LTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH 434
Score = 89.0 bits (219), Expect = 2e-17
Identities = 75/260 (28%), Positives = 118/260 (45%), Gaps = 6/260 (2%)
Query: 33 TACPAPCHCQEDGIMLSADCSELGLSAVPGDLD--PLTAYLDLSMNNLTELQPGLFHHLR 90
T A C +L + +S +P + P +L+L N + ++ F L
Sbjct: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLD 239
Query: 91 FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 150
L L++ N +S + AF GL +++ L L++N L + L+ L LQ L + N I
Sbjct: 240 SLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAI 299
Query: 151 SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 210
+ ++E L L L N LT + A L L+ + L NR++HI D F+ L+
Sbjct: 300 ERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLS 359
Query: 211 SLVVLHLHNNRIQHL---GTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHN 266
+L L L NN I + +F GL +L L L N+++ A L L+ L +N
Sbjct: 360 NLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNN 419
Query: 267 NNIKAIPEKAFMGNPLLQTI 286
N I +I E AF L + I
Sbjct: 420 NAIMSIQENAFSQTHLKELI 439
Score = 85.5 bits (210), Expect = 2e-16
Identities = 70/210 (33%), Positives = 103/210 (49%), Gaps = 6/210 (2%)
Query: 64 LDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQN 123
LD L + L + N +++L+ G F L +EEL L N+L+ + GL L+ L +
Sbjct: 238 LDSLRS-LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQ 296
Query: 124 NQLGGIPAEALWEL-PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRAL 182
N + I +A WE L L L N ++ + E +F GLS L L L DN +T I
Sbjct: 297 NAIERISPDA-WEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355
Query: 183 NNLPALQAMTLALNRISHIPD---YAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETL 239
L LQ + L N IS + AF LTSL L L N+I+ + +F GL +LE L
Sbjct: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHL 415
Query: 240 DLNYNKLQEFPVAIRTLGRLQELGFHNNNI 269
DLN N + + L+EL + +++
Sbjct: 416 DLNNNAIMSIQENAFSQTHLKELILNTSSL 445
Score = 82.4 bits (202), Expect = 2e-15
Identities = 91/349 (26%), Positives = 146/349 (41%), Gaps = 24/349 (6%)
Query: 118 ILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 177
+L+L G PA +P L R +P S+ LS L D A+ +
Sbjct: 32 LLLLPAAGAGLCPAPCSCRIPLLDCSRRK------LPAPSWRALSGLLP---PDTAILDF 82
Query: 178 PVRALNNL------PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 231
L+N LQ + + N ++ IP Y + +++ +L L +N I + + +
Sbjct: 83 SHNRLSNWNISLESQTLQEVKMNYNELTEIP-YFGEPTSNITLLSLVHNIIPEINAQALQ 141
Query: 232 GLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMG-NPLLQTIHFYD 290
LE+LDL+ N + E + +L+ L NN I + F + L +
Sbjct: 142 FYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNR 201
Query: 291 NPIQFVGRSAFQYLPKLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQ 349
N + + F+ LP L L L + I E +G SL L + R GI L G
Sbjct: 202 NRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFF 260
Query: 350 QLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 407
L + LEL HN + + L+ + L+++ + N I I D + L LDLS+
Sbjct: 261 GLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSY 320
Query: 408 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 453
N + + AF L L +L+L DN++T + L L L L+ N
Sbjct: 321 NQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNN 369
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 138 bits (347), Expect = 3e-32
Identities = 116/430 (26%), Positives = 186/430 (43%), Gaps = 32/430 (7%)
Query: 7 LRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDP 66
LR LCA L R QP P P AC C ++ D + + +P +L
Sbjct: 2 LRGTLLCAVLGLLRA-----QPFPCPPACK--CVFRDAAQCSGGDVARISALGLPTNLTH 54
Query: 67 LTAY--------------------LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIP 106
+ + L +S ++++ + PG F L L+ LRLS N ++H+P
Sbjct: 55 ILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLP 114
Query: 107 GQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRH 166
G + L+ L L +N L GI +L +LQ L L+ N + +P F L +L+
Sbjct: 115 GALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKL 174
Query: 167 LWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 226
L L N LT +P L L+ + L NR+ + +L +L L H N I+ +
Sbjct: 175 LDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIA 234
Query: 227 THSFEGLHNLETLDLNYNKLQEFPVAIRTLG-RLQELGFHNNNIKAIPEKAFMGNPLLQT 285
+F+ L NL +L L+ N L P A+ L L N + +P F LQ
Sbjct: 235 PGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQE 294
Query: 286 IHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLL 343
+ ++ + +AF+ L +L L + + + P +G L++L L G+ L
Sbjct: 295 LWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTAL 354
Query: 344 PSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 401
P G+ + L +LR + L N++ LP LE + L HN++ + D F L L
Sbjct: 355 PDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLT 414
Query: 402 ALDLSWNAIR 411
+ L N+ R
Sbjct: 415 EVLLGHNSWR 424
Score = 68.2 bits (165), Expect = 4e-11
Identities = 63/236 (26%), Positives = 102/236 (43%), Gaps = 29/236 (12%)
Query: 208 NLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHN 266
NLT +++ + +Q + SF G+ L+ L ++ + + P L +L+ L
Sbjct: 51 NLTHILLFGMGRGVLQ---SQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSR 107
Query: 267 NNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKG 326
N I +P LL+ + N ++ + ++ FQ L L L+LN
Sbjct: 108 NKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALN------------- 154
Query: 327 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHN 384
+ + LP+ + L L++L+LS N + LP L KLE + L N
Sbjct: 155 ----------QNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSN 204
Query: 385 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA 440
R+ + + + L +L L N IRSI P AF L +L L L+ N L LP A
Sbjct: 205 RLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/144 (31%), Positives = 69/144 (47%), Gaps = 2/144 (1%)
Query: 308 HTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 367
H L + + G T L+ L ++ + I + G L +L+ L LS N+I L
Sbjct: 54 HILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHL 113
Query: 368 PS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLV 425
P L + LE++ L HN + I + F +L +LQ L L+ N + + F+ L +L
Sbjct: 114 PGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLK 173
Query: 426 KLDLTDNQLTTLPLAGLGGLMHLK 449
LDL+ N LT LP LG L+
Sbjct: 174 LLDLSGNNLTHLPKGLLGAQAKLE 197
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 136 bits (342), Expect = 1e-31
Identities = 127/430 (29%), Positives = 187/430 (43%), Gaps = 67/430 (15%)
Query: 32 PTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRF 91
P ACPA C C + DC L L +VP ++ R
Sbjct: 25 PQACPAQCSCSGSTV----DCHGLALRSVPRNIP------------------------RN 56
Query: 92 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLIS 151
E L L+GN+++ I F+GL L++L L N++ I A +L L+ LRL+ N +
Sbjct: 57 TERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQ 116
Query: 152 LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTS 211
L PE F G + L L L +N + IP +A ++ + L N+IS I D AF+ L
Sbjct: 117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRD 176
Query: 212 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL--------------QEFPVAIRTLG 257
L VL L+NN I L SF + L T L+ N L Q V + T
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYT-- 234
Query: 258 RLQELG---FHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRS-AFQYLPKLHTLSLN 313
Q +G +N+ + ++ F+ F+ S + + P T S N
Sbjct: 235 --QCMGPSHLRGHNVAEVQKREFV----------CSGHQSFMAPSCSVLHCPAACTCSNN 282
Query: 314 ----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL-- 367
+ E P T EI L + I+++P G +LR ++LS+NQI EL
Sbjct: 283 IVDCRGKGLTEIPTNLPETITEI-RLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAP 341
Query: 368 PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 427
+ + L + L N+I E+ F L SLQ L L+ N I + +AF LH+L L
Sbjct: 342 DAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLL 401
Query: 428 DLTDNQLTTL 437
L DN+L T+
Sbjct: 402 SLYDNKLQTI 411
Score = 109 bits (273), Expect = 1e-23
Identities = 110/407 (27%), Positives = 175/407 (42%), Gaps = 24/407 (5%)
Query: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94
CPA C C + + DC GL+ +P +L + L N + + PG F + L
Sbjct: 273 CPAACTCSNNIV----DCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRR 328
Query: 95 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 154
+ LS N +S + AF GL SL L+L N++ +P L SLQ L L+AN I+ +
Sbjct: 329 IDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLR 388
Query: 155 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 214
+F+ L +L L L DN L I + L A+Q M LA N I D + L
Sbjct: 389 VDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQN--PFICDCHLKWLAD--- 443
Query: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIK---- 270
+LH N I+ G L + K ++F + + + + + +
Sbjct: 444 -YLHTNPIETSGARC-TSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCF 501
Query: 271 ---AIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGT 327
A PEK T+ + + + QY +L L+ N ++ K
Sbjct: 502 ADLACPEKCRCEG---TTVDCSNQKLNKIPEHIPQYTAELR-LNNNEFTVLEATGIFKKL 557
Query: 328 TSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL--PSLHRCQKLEEIGLQHNR 385
L + + I + G + + + L+ N++E + + L+ + L+ NR
Sbjct: 558 PQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNR 617
Query: 386 IWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 432
I +G D+F LSS++ L L N I ++ P AF TLHSL L+L N
Sbjct: 618 ITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664
Score = 93.6 bits (231), Expect = 8e-19
Identities = 90/327 (27%), Positives = 147/327 (44%), Gaps = 25/327 (7%)
Query: 141 QSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH 200
+ L L+ N I+ + + F GL LR L L +N ++ I A +L L+ + L N +
Sbjct: 58 ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQL 117
Query: 201 IPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRL 259
P+ F L L L N+IQ + +F G +++ L L+YN++ A R L L
Sbjct: 118 FPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDL 177
Query: 260 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF-----QYLPK--LHTLSL 312
+ L +NNNI + +F P L+T + N + A+ + P+ L+T +
Sbjct: 178 EVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCM 237
Query: 313 NGAMDIQEFPDLKGTTSLEILT--LTRAGIRLLPSGMCQQLPRLRVLELSHNQIE----- 365
+ L+G E+ +G + + C L S+N ++
Sbjct: 238 GPS-------HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKG 290
Query: 366 --ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHS 423
E+P+ + + + EI L+ N I I FS L+ +DLS N I + P+AF L S
Sbjct: 291 LTEIPT-NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRS 349
Query: 424 LVKLDLTDNQLTTLPLAGLGGLMHLKL 450
L L L N++T LP + GL L+L
Sbjct: 350 LNSLVLYGNKITELPKSLFEGLFSLQL 376
Score = 88.2 bits (217), Expect = 3e-17
Identities = 95/330 (28%), Positives = 143/330 (43%), Gaps = 27/330 (8%)
Query: 143 LRLDANLISLVPERS-FEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI 201
LRL+ N +++ F+ L LR + +N +T+I A + + L NR+ ++
Sbjct: 538 LRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENV 597
Query: 202 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQ 260
F+ L SL L L +NRI +G SF GL ++ L L N++ P A TL L
Sbjct: 598 QHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLS 657
Query: 261 ELGFHNNNIKAIPEKAFM-----------GNPLLQTIHFY-DNPIQFVGRSAFQYLPKLH 308
L N A++ GNP Q +F + PIQ V A Q
Sbjct: 658 TLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDV---AIQDFTCDD 714
Query: 309 TLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR-LRVLELSHNQIEEL 367
N + P + T ++ + G+++LP G +PR + L L NQ +
Sbjct: 715 GNDDNSCSPLSRCP-TECTCLDTVVRCSNKGLKVLPKG----IPRDVTELYLDGNQFTLV 769
Query: 368 P-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVK 426
P L + L I L +NRI + +FS ++ L L LS+N +R I P F L SL
Sbjct: 770 PKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRL 829
Query: 427 LDLTDNQLTTLP---LAGLGGLMHLKLKGN 453
L L N ++ +P L L HL + N
Sbjct: 830 LSLHGNDISVVPEGAFNDLSALSHLAIGAN 859
Score = 83.6 bits (205), Expect = 8e-16
Identities = 55/164 (33%), Positives = 84/164 (51%), Gaps = 5/164 (3%)
Query: 34 ACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQP-GLFHHLRFL 92
ACP C C+ + DCS L+ +P + TA L L+ N T L+ G+F L L
Sbjct: 505 ACPEKCRCEGTTV----DCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQL 560
Query: 93 EELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISL 152
++ S N ++ I AF G + ++L +N+L + + L SL++L L +N I+
Sbjct: 561 RKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITC 620
Query: 153 VPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALN 196
V SF GLSS+R L L DN +T + A + L +L + L N
Sbjct: 621 VGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664
Score = 70.1 bits (170), Expect = 1e-11
Identities = 49/142 (34%), Positives = 69/142 (48%), Gaps = 9/142 (6%)
Query: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDL--DPLTAYLDLSMNNLTELQPGLFHHLRFL 92
CP C C + + CS GL +P + D YLD + L + + HL +
Sbjct: 727 CPTECTCLDTVVR----CSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLI 782
Query: 93 EELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISL 152
+ LS N +S + Q+FS + L L+L N+L IP L SL+ L L N IS+
Sbjct: 783 D---LSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISV 839
Query: 153 VPERSFEGLSSLRHLWLDDNAL 174
VPE +F LS+L HL + N L
Sbjct: 840 VPEGAFNDLSALSHLAIGANPL 861
Score = 50.8 bits (120), Expect = 6e-06
Identities = 36/107 (33%), Positives = 54/107 (50%), Gaps = 7/107 (6%)
Query: 143 LRLDANLISLVPERSFEGLSSLRHLWLDD---NALTEIPVRALNNLPALQAMTLALNRIS 199
L LD N +LVP+ LS+ +HL L D N ++ + ++ +N+ L + L+ NR+
Sbjct: 759 LYLDGNQFTLVPKE----LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLR 814
Query: 200 HIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 246
IP F L SL +L LH N I + +F L L L + N L
Sbjct: 815 CIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
Score = 37.7 bits (86), Expect = 0.052
Identities = 34/123 (27%), Positives = 52/123 (42%), Gaps = 9/123 (7%)
Query: 357 LELSHNQIEELPSLHRC--QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIH 414
L+L+ N I + + L + L N+I I F L L+ L L+ N ++
Sbjct: 60 LDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFP 119
Query: 415 PEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALS----QAFSKDSFPKLRI 470
F L +LDL++NQ+ +P G + +K NL L +F LR
Sbjct: 120 ELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIK---NLQLDYNQISCIEDGAFRALRD 176
Query: 471 LEV 473
LEV
Sbjct: 177 LEV 179
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 136 bits (342), Expect = 1e-31
Identities = 130/455 (28%), Positives = 184/455 (40%), Gaps = 68/455 (14%)
Query: 5 PGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDL 64
PG LW L A QP CP C C + CS+ L+ VP D+
Sbjct: 3 PGAWLLWTSLLLLAR-----PAQP------CPMGCDCFVQEVF----CSDEELATVPLDI 47
Query: 65 DPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNN 124
P T + + T L+ +AF +L ++ N
Sbjct: 48 PPYTKNIIFVETSFTTLET------------------------RAFGSNPNLTKVVFLNT 83
Query: 125 QLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNN 184
QL +A LP L+ L + + + F L+SL L L+ N L +P +
Sbjct: 84 QLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQH 143
Query: 185 LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYN 244
L AL+++ L N++ +P FQ LT L L+L N + L F L +L+TL L+ N
Sbjct: 144 LAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNN 203
Query: 245 KLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQY 303
L P + LG LQEL +NNI +P + F L+ + N I + S F
Sbjct: 204 ALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFAS 263
Query: 304 LPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 363
L L LSL M +R+LP+G+ P L L L+HNQ
Sbjct: 264 LGNLTFLSLQWNM-----------------------LRVLPAGLFAHTPCLVGLSLTHNQ 300
Query: 364 IEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 421
+E + + L + L +N I + A F L L L L N + ++HP F L
Sbjct: 301 LETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNL 360
Query: 422 HSLVKLDLTDNQLTTLPLAGLG---GLMHLKLKGN 453
L L L+ NQLTTLP L +L L GN
Sbjct: 361 SKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 112 bits (280), Expect = 2e-24
Identities = 82/273 (30%), Positives = 120/273 (43%), Gaps = 49/273 (17%)
Query: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
L L+ N L L GLF HL LE L L GN L +P + F L LK L L N L +P
Sbjct: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
Query: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
E L SLQ+L+L N +S +P+ F L SL+ L+LD N ++E+P + + L L+
Sbjct: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 191 MTLALNRISHIPDYAFQNLTSLVVLHLH------------------------NNRIQHLG 226
+ L N I+H+P F +L +L L L +N+++ +
Sbjct: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVA 305
Query: 227 THSFEGLHNLETLDLNYNKLQEFPVAI-------------------------RTLGRLQE 261
+F L NL +L L+YN + P I + L +L+
Sbjct: 306 EGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLEL 365
Query: 262 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQ 294
L N + +PE F N L + + NP Q
Sbjct: 366 LSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQ 398
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 132 bits (332), Expect = 2e-30
Identities = 121/430 (28%), Positives = 193/430 (44%), Gaps = 62/430 (14%)
Query: 31 GPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLR 90
G +ACPA C C + DC GL A+P ++ R
Sbjct: 30 GASACPALCTCTGTTV----DCHGTGLQAIPKNIP------------------------R 61
Query: 91 FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 150
E L L+GN+++ I F+GL L++L L NQ+G + A ++ L+ LRL+ N +
Sbjct: 62 NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Query: 151 SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 210
++PE F+ +L L L +NA+ IP +A L+ + L N+IS I + AF+ L
Sbjct: 122 HMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALR 181
Query: 211 SLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK---------LQEFPVAIRTLGRLQE 261
L VL L+NN I + SF + L T L+ N L ++ T+G +
Sbjct: 182 GLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQ 241
Query: 262 ----LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 317
N+ + + F + + P + + P + T S NG +D
Sbjct: 242 CSGPASLRGLNVAEVQKSEFSCSGQGEAGRV---PTCTLSSGS---CPAMCTCS-NGIVD 294
Query: 318 IQEFPDLKGTTSL-----EILTLTRA---GIRLLPSGMCQQLPRLRVLELSHNQIEEL-- 367
+ KG T++ E +T R GI+ +P G +LR ++LS+NQI E+
Sbjct: 295 CRG----KGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAP 350
Query: 368 PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 427
+ + L + L N+I ++ F L +LQ L L+ N I I P+AF L +L L
Sbjct: 351 DAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLL 410
Query: 428 DLTDNQLTTL 437
L DN++ +L
Sbjct: 411 SLYDNKIQSL 420
Score = 112 bits (280), Expect = 2e-24
Identities = 137/519 (26%), Positives = 209/519 (40%), Gaps = 66/519 (12%)
Query: 4 PPGLRALWLCAALCASRRAGGAPQPGPGPT------ACPAPCHCQEDGIMLSADCSELGL 57
P LR L + + G + G PT +CPA C C +GI+ DC GL
Sbjct: 245 PASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCS-NGIV---DCRGKGL 300
Query: 58 SAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLK 117
+A+P +L + L +N + + PG F R L + LS N ++ I AF GL SL
Sbjct: 301 TAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLN 360
Query: 118 ILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 177
L+L N++ +P L +LQ L L+AN I+ + +F+ L +L L L DN + +
Sbjct: 361 SLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSL 420
Query: 178 PVRALNNLPALQAMTLALN------RISHIPDYAFQN------LTSLVVLHLHNNRIQHL 225
+L A+Q + LA N + + D+ N L N RI +
Sbjct: 421 AKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQI 480
Query: 226 GTHSFE-------GLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFM 278
+ F + E LN + + + + + IPE+
Sbjct: 481 KSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQ 540
Query: 279 GNPLLQTIHFYDNPIQFV-GRSAFQYLPKLHTLSL-NGAMDIQEFPDLKGTTSLEILTLT 336
L+ +N I + F+ L L ++L N + E +G S+ L LT
Sbjct: 541 STAELR---LNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLT 597
Query: 337 RAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQ 396
+ + SGM + L LR L L +N+I + HN D+F+
Sbjct: 598 ANQLESIRSGMFRGLDGLRTLMLRNNRISCI---------------HN-------DSFTG 635
Query: 397 LSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLT-TLPLAGLGGLMHLK--LKGN 453
L +++ L L N I ++ P AF TL SL L+L N LA LGG + + + GN
Sbjct: 636 LRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVTGN 695
Query: 454 LA------LSQAFSKD-SFPKLRILEVPYAYQCCPYGMC 485
L Q +D +FP R E C P C
Sbjct: 696 PRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQC 734
Score = 106 bits (265), Expect = 9e-23
Identities = 96/331 (29%), Positives = 149/331 (45%), Gaps = 30/331 (9%)
Query: 141 QSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH 200
+ L L+ N I+ + + F GL LR L L +N + + A +++ L+ + L N++
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123
Query: 201 IPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGRL 259
+P+ FQN +L L L N IQ + +F G +L+ L L+ N++ A R L L
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 183
Query: 260 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF--QYLPKLHTLSLNGAMD 317
+ L +NNNI IP +F P L+T + N + A+ Q+L + T+ L
Sbjct: 184 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGL----- 238
Query: 318 IQEFPDLKGTTSLEILTLT----------------RAGIRLLPSGMCQQLPRLR--VLEL 359
F G SL L + R L SG C + +++
Sbjct: 239 ---FTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDC 295
Query: 360 SHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 419
+ +P+ + + + EI L+ N I I FS L+ +DLS N I I P+AF
Sbjct: 296 RGKGLTAIPA-NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQ 354
Query: 420 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 450
L SL L L N++T LP GGL L+L
Sbjct: 355 GLRSLNSLVLYGNKITDLPRGVFGGLYTLQL 385
Score = 91.3 bits (225), Expect = 4e-18
Identities = 94/341 (27%), Positives = 152/341 (44%), Gaps = 25/341 (7%)
Query: 119 LMLQNNQLGGIPAEALWE-LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 177
L L NN++ + A +++ L L+ + L N +S + + +FEG +S+ L L N L I
Sbjct: 545 LRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESI 604
Query: 178 PVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLE 237
L L+ + L NRIS I + +F L ++ +L L++N+I + +F+ L +L
Sbjct: 605 RSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLS 664
Query: 238 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN-PIQFV 296
TL+L N G L++ K GNP Q F P+Q V
Sbjct: 665 TLNLLANPFNCNCQLAWLGGWLRK------------RKIVTGNPRCQNPDFLRQIPLQDV 712
Query: 297 GRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRV 356
AF G + + P ++ + +R LP G+ + + L
Sbjct: 713 ---AFPDFRCEEGQEEGGCLPRPQCPQECACLDT-VVRCSNKHLRALPKGIPKNVTELY- 767
Query: 357 LELSHNQIEELPS-LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHP 415
L NQ +P L + L+ + L +N+I + +F+ +S L L LS+NA++ I P
Sbjct: 768 --LDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPP 825
Query: 416 EAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 453
AF L SL L L N ++TL A + L HL + N
Sbjct: 826 LAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
Score = 51.2 bits (121), Expect = 5e-06
Identities = 44/180 (24%), Positives = 74/180 (41%), Gaps = 32/180 (17%)
Query: 17 CASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMN 76
C + G P P CP C C + + CS L A+P +
Sbjct: 719 CEEGQEEGGCLPRP---QCPQECACLDTVVR----CSNKHLRALPKGIP----------K 761
Query: 77 NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWE 136
N+TEL L GN + +PGQ + Y L+++ L NN++ + +
Sbjct: 762 NVTELY--------------LDGNQFTLVPGQLSTFKY-LQLVDLSNNKISSLSNSSFTN 806
Query: 137 LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALN 196
+ L +L L N + +P +F+GL SLR L L N ++ + ++ +L + + N
Sbjct: 807 MSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/111 (32%), Positives = 55/111 (49%), Gaps = 7/111 (6%)
Query: 139 SLQSLRLDANLISLVPERSFEGLSSLRHLWLDD---NALTEIPVRALNNLPALQAMTLAL 195
++ L LD N +LVP + LS+ ++L L D N ++ + + N+ L + L+
Sbjct: 762 NVTELYLDGNQFTLVPGQ----LSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSY 817
Query: 196 NRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKL 246
N + IP AFQ L SL +L LH N I L F + +L L + N L
Sbjct: 818 NALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/136 (29%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 351 LPRLRVLELSHNQIE--ELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408
L +LRVL+L NQI E + ++LE + L N++ + F +L LDLS N
Sbjct: 84 LKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSEN 143
Query: 409 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL----KGNLALSQAFSKDS 464
AI++I +AF L L L NQ++ + L L++ N+ S +
Sbjct: 144 AIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNH 203
Query: 465 FPKLRILEVPYAYQCC 480
PKLR + + C
Sbjct: 204 MPKLRTFRLHSNHLFC 219
Score = 45.1 bits (105), Expect = 3e-04
Identities = 29/83 (34%), Positives = 41/83 (49%), Gaps = 1/83 (1%)
Query: 212 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP-VAIRTLGRLQELGFHNNNIK 270
L ++ L NN+I L SF + L TL L+YN LQ P +A + L L+ L H N+I
Sbjct: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 271 AIPEKAFMGNPLLQTIHFYDNPI 293
+ E F L + NP+
Sbjct: 846 TLQEGIFADVTSLSHLAIGANPL 868
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 132 bits (331), Expect = 2e-30
Identities = 96/332 (28%), Positives = 160/332 (48%), Gaps = 4/332 (1%)
Query: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEE 94
CPA C C S C L A+P + T LDLS N L + P F LEE
Sbjct: 28 CPARCECSAQN--KSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEE 85
Query: 95 LRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVP 154
+ LS N ++++ AF+ L++L+ L L+ N+L +P L +L L + N I ++
Sbjct: 86 IDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILL 145
Query: 155 ERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVV 214
+ F+ L +L+ L + DN L I RA + L +L+ +TL ++ +P A +L SL+
Sbjct: 146 DYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIS 205
Query: 215 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLG-RLQELGFHNNNIKAIP 273
LHL + I ++ ++F+ L +L+ L+++Y L + A G L L N N+ +P
Sbjct: 206 LHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVP 265
Query: 274 EKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA-MDIQEFPDLKGTTSLEI 332
AF L ++ NPI + F L +L L + GA + E +G L +
Sbjct: 266 FLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRV 325
Query: 333 LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
L +++ + L + L VL +++N +
Sbjct: 326 LNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 59.3 bits (142), Expect = 2e-08
Identities = 55/193 (28%), Positives = 80/193 (41%), Gaps = 31/193 (16%)
Query: 262 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEF 321
L N +K++ + F+ PLL+ I DN I V AF L L +L L G
Sbjct: 62 LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNR----- 116
Query: 322 PDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL-----PSLHRCQKL 376
++L+P G+ L L L++S N+I L LH + L
Sbjct: 117 ------------------LKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSL 158
Query: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 436
E + N + I FS L SL+ L L + ++ EA S L SL+ L L +
Sbjct: 159 E---VGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINN 215
Query: 437 LPLAGLGGLMHLK 449
+P+ L HLK
Sbjct: 216 MPVYAFKRLFHLK 228
Score = 44.3 bits (103), Expect = 6e-04
Identities = 33/121 (27%), Positives = 58/121 (47%), Gaps = 2/121 (1%)
Query: 331 EILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWE 388
+IL L++ ++ + P L ++LS N I + + + L + L+ NR+
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKL 119
Query: 389 IGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHL 448
+ F+ LS+L LD+S N I + F LH+L L++ DN L + GL+ L
Sbjct: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSL 179
Query: 449 K 449
+
Sbjct: 180 E 180
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 131 bits (330), Expect = 3e-30
Identities = 108/356 (30%), Positives = 160/356 (44%), Gaps = 7/356 (1%)
Query: 11 WLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAY 70
WLC AP P G CPA C C ++ C+ L+AVP + T
Sbjct: 4 WLCVLSLPLLLLPAAPPPAGG---CPARCECTVQTRAVA--CTRRRLTAVPDGIPAETRL 58
Query: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
L+LS N + L PG L LEEL LS N ++H+ AF+ L L++L L+ NQL IP
Sbjct: 59 LELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIP 118
Query: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
L +L L L N + ++ + +F+ L SLR L + DN L + RA L AL+
Sbjct: 119 PGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEE 178
Query: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL-NYNKLQEF 249
+TL ++ + + +L SL L L + I L +F L L L++ N+ L+E
Sbjct: 179 LTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEV 238
Query: 250 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
L L + NI A+P A L ++ NPI V R +F+ L +L
Sbjct: 239 AAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRE 298
Query: 310 LSLNGA-MDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
L L GA + + E G + +L L+ + L + L L + N +
Sbjct: 299 LHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354
Score = 84.3 bits (207), Expect = 5e-16
Identities = 83/313 (26%), Positives = 134/313 (42%), Gaps = 33/313 (10%)
Query: 128 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 187
GIPAE + L L N I + L +L L L +NA+ + A NLP
Sbjct: 51 GIPAET-------RLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPR 103
Query: 188 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 247
L+ + L N++ IP F L +L +L L N++ L ++F+ LH+L L++ N L
Sbjct: 104 LRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLV 163
Query: 248 EFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 306
A L L+EL N+ A+ ++ L + I + F+ LP
Sbjct: 164 FVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPG 223
Query: 307 LHTLSLNGAMDIQEFP--DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
L L ++ ++E L+G +L L++T I +P+ + L L LSHN I
Sbjct: 224 LLHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPI 282
Query: 365 EELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSL 424
+P +F L L+ L L+ + + P+AF L +
Sbjct: 283 STVPR----------------------GSFRDLVRLRELHLAGALLAVVEPQAFLGLRQI 320
Query: 425 VKLDLTDNQLTTL 437
L+L++N L+TL
Sbjct: 321 RLLNLSNNLLSTL 333
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/120 (32%), Positives = 60/120 (50%), Gaps = 2/120 (1%)
Query: 332 ILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEI 389
+L L+R IR L G LP L L+LS N I + + +L + L+ N++ I
Sbjct: 58 LLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLI 117
Query: 390 GADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK 449
F++L +L LDLS N + + F LHSL +L++ DN L + GL+ L+
Sbjct: 118 PPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALE 177
Score = 54.7 bits (130), Expect = 4e-07
Identities = 46/136 (33%), Positives = 65/136 (47%), Gaps = 5/136 (3%)
Query: 323 DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIG 380
DL +LE L L+ I + G LPRLRVL L NQ++ +P R L +
Sbjct: 73 DLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLD 132
Query: 381 LQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA 440
L N++ + TF L SL+ L++ N + + AF+ L +L +L L LT L
Sbjct: 133 LSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGE 192
Query: 441 GLGGLMHLKLKGNLAL 456
LG HL+ G L L
Sbjct: 193 SLG---HLRSLGALRL 205
Score = 52.0 bits (123), Expect = 3e-06
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 327 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHN 384
T + TR + +P G+ + R+LELS N+I L L LEE+ L N
Sbjct: 32 TVQTRAVACTRRRLTAVPDGIPAET---RLLELSRNRIRCLNPGDLAALPALEELDLSEN 88
Query: 385 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL 437
I + F+ L L+ L L N ++ I P F+ L +L LDL++N+L L
Sbjct: 89 AIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVIL 141
Score = 30.4 bits (67), Expect = 8.4
Identities = 15/33 (45%), Positives = 21/33 (63%)
Query: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS 103
L+LS N L+ L+ FH + LE LR+ GN L+
Sbjct: 323 LNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 130 bits (326), Expect = 8e-30
Identities = 121/435 (27%), Positives = 186/435 (42%), Gaps = 70/435 (16%)
Query: 29 GPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHH 88
GP ACP C C S DC LGL AVP + LDL NN+T
Sbjct: 28 GPPAVACPTKCTCSA----ASVDCHGLGLRAVPRGIPRNAERLDLDRNNIT--------- 74
Query: 89 LRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDAN 148
I F+GL +L++L L++NQ+ I A +L L+ LRL+ N
Sbjct: 75 ---------------RITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKN 119
Query: 149 LISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQN 208
+ ++PE F+ L L L +N + IP +A + ++ + L N IS I D AF+
Sbjct: 120 KLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRA 179
Query: 209 LTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK---------LQEFPVAIRTLGR- 258
L L +L L+NN I + SF + + TL L+ N L ++ RT+G+
Sbjct: 180 LRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQF 239
Query: 259 ---LQELGFHNNNIKAIPEKAFM-GNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
+ + N+ + +K ++ P + N I P T S N
Sbjct: 240 TLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSIS---------CPSPCTCSNN- 289
Query: 315 AMDIQEFPDLKGTTSLEI----------LTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
D +G +EI + L + I+ +P+G Q +L+ +++S NQI
Sbjct: 290 ------IVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQI 343
Query: 365 EEL--PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH 422
++ + + L + L N+I EI F L SLQ L L+ N I + F L
Sbjct: 344 SDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQ 403
Query: 423 SLVKLDLTDNQLTTL 437
+L L L DN+L T+
Sbjct: 404 NLNLLSLYDNKLQTI 418
Score = 95.5 bits (236), Expect = 2e-19
Identities = 116/468 (24%), Positives = 188/468 (40%), Gaps = 65/468 (13%)
Query: 26 PQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGL 85
P +CP+PC C + + DC GL +P +L + L N++ + G
Sbjct: 271 PSCNANSISCPSPCTCSNNIV----DCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGA 326
Query: 86 FHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRL 145
F + L+ + +S N +S I AF GL SL L+L N++ I L SLQ L L
Sbjct: 327 FTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLL 386
Query: 146 DANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALN------RIS 199
+AN I+ + +F+ L +L L L DN L I L ++Q + LA N +
Sbjct: 387 NANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLK 446
Query: 200 HIPDYAFQN--------------LTSLVVLHLHNNRIQHLGTHSFEGLHNLET-LDLNYN 244
+ DY N L + + + + + + G+ + + E +DL
Sbjct: 447 WLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDL--- 503
Query: 245 KLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFV-GRSAFQY 303
P R G + + N + IP + + DN + + F+
Sbjct: 504 ---VCPEKCRCEGTIVDCS--NQKLVRIPSHL---PEYVTDLRLNDNEVSVLEATGIFKK 555
Query: 304 LPKLHTLSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 361
LP L ++L N +++E G S++ L LT + + + + L L+ L L
Sbjct: 556 LPNLRKINLSNNKIKEVRE-GAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLML-- 612
Query: 362 NQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 421
+ N I + DTF+ LSS++ L L N I +I P AF+TL
Sbjct: 613 --------------------RSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTL 652
Query: 422 HSLVKLDLTDNQLT-TLPLAGLGGLMHLK--LKGNLALSQAFSKDSFP 466
SL ++L N LA LG + + + GN + F P
Sbjct: 653 VSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIP 700
Score = 93.2 bits (230), Expect = 1e-18
Identities = 99/343 (28%), Positives = 153/343 (44%), Gaps = 30/343 (8%)
Query: 119 LMLQNNQLGGIPAEALWE-LPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEI 177
L L +N++ + A +++ LP+L+ + L N I V E +F+G +S++ L L N L +
Sbjct: 537 LRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETV 596
Query: 178 PVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLE 237
R L L+ + L N I + + F L+S+ +L L++NRI + +F L +L
Sbjct: 597 HGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLS 656
Query: 238 TLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDN-PIQFV 296
T++L N + LG+ + GNP Q F PIQ V
Sbjct: 657 TINLLSNPFN-CNCHLAWLGKWLR-----------KRRIVSGNPRCQKPFFLKEIPIQDV 704
Query: 297 GRSAFQYLPKLHTLSLNGAMDIQEFPDL-KGTTSLE-ILTLTRAGIRLLPSGMCQQLPRL 354
F T N Q P + T +E ++ + G+R LP GM + + L
Sbjct: 705 AIQDF-------TCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTEL 757
Query: 355 RVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI 413
L N + +P L + L I L +N I + TFS +S L L LS+N +R I
Sbjct: 758 Y---LEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCI 814
Query: 414 HPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 453
AF+ L SL L L N ++++P L L HL L N
Sbjct: 815 PVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTN 857
Score = 81.6 bits (200), Expect = 3e-15
Identities = 95/360 (26%), Positives = 138/360 (38%), Gaps = 35/360 (9%)
Query: 35 CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQP-GLFHHLRFLE 93
CP C C+ + DCS L +P L L L+ N ++ L+ G+F L L
Sbjct: 505 CPEKCRCEGTIV----DCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560
Query: 94 ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV 153
++ LS N + + AF G S++ LML NQL + L L++L L +NLI V
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCV 620
Query: 154 PERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAF------- 206
+F GLSS+R L L DN +T I A L +L + L N + A+
Sbjct: 621 SNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK 680
Query: 207 -----QNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGR--- 258
N L IQ + F N E+ + E + T+ R
Sbjct: 681 RRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSN 740
Query: 259 -------------LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLP 305
+ EL N++ A+P + L I +N I + F +
Sbjct: 741 KGLRALPRGMPKDVTELYLEGNHLTAVP-RELSALRHLTLIDLSNNSISMLTNYTFSNMS 799
Query: 306 KLHTLSLN-GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
L TL L+ + G SL +LTL I +P G L L L L N +
Sbjct: 800 HLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Score = 58.2 bits (139), Expect = 4e-08
Identities = 48/146 (32%), Positives = 69/146 (47%), Gaps = 8/146 (5%)
Query: 143 LRLDANLISLVPERSFEGLSSLRHLWLDD---NALTEIPVRALNNLPALQAMTLALNRIS 199
L L+ N ++ VP LS+LRHL L D N+++ + +N+ L + L+ NR+
Sbjct: 757 LYLEGNHLTAVPRE----LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLR 812
Query: 200 HIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRL 259
IP +AF L SL VL LH N I + SF L +L L L N L ++R L
Sbjct: 813 CIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL-HCDCSLRWLSEW 871
Query: 260 QELGFHNNNIKAIPEKAFMGNPLLQT 285
+ G+ I M + LL T
Sbjct: 872 VKAGYKEPGIARCSSPEPMADRLLLT 897
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/141 (26%), Positives = 64/141 (45%), Gaps = 12/141 (8%)
Query: 339 GIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRC--QKLEEIGLQHNRIWEIGADTFSQ 396
G+R +P G+ + RL +L N I + + + L + L+ N++ I F
Sbjct: 51 GLRAVPRGIPRNAERL---DLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQD 107
Query: 397 LSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLAL 456
L L+ L L+ N ++ + F + L +LDL++NQ+ +P G+ +K NL L
Sbjct: 108 LKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVK---NLQL 164
Query: 457 S----QAFSKDSFPKLRILEV 473
+F LR LE+
Sbjct: 165 DNNHISCIEDGAFRALRDLEI 185
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 128 bits (322), Expect = 2e-29
Identities = 90/282 (31%), Positives = 135/282 (47%), Gaps = 5/282 (1%)
Query: 34 ACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLE 93
ACP C C++ L C G +VP D + L L N++TEL+ F L
Sbjct: 33 ACPPKCRCEK----LLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLT 88
Query: 94 ELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV 153
L L N +S + AF GLY LK L+L +N++ +P +L +LQ+L L N +S +
Sbjct: 89 WLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSL 148
Query: 154 PERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLV 213
F GL L+ L L N+L IPVR + +L+ + L+ NR+ + F L L
Sbjct: 149 HPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLR 208
Query: 214 VLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIR-TLGRLQELGFHNNNIKAI 272
LHL +N++ + F L +L TL L +NK+ + T G L++L N IKAI
Sbjct: 209 ELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAI 268
Query: 273 PEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNG 314
F P L+ + +N + + L L T+ L+G
Sbjct: 269 DLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSG 310
Score = 85.1 bits (209), Expect = 3e-16
Identities = 77/270 (28%), Positives = 124/270 (45%), Gaps = 29/270 (10%)
Query: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
++L N I+ + F + + L LHL +N+I + +F+GL+ L+ L L+ NK+ P
Sbjct: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
Query: 251 VAIRT-LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
T L LQ L N + ++ + F G LQT+H N ++ +
Sbjct: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTI------------- 172
Query: 310 LSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 369
++ F D + SLE L L+ +R L L +LR L L HNQ+ ++
Sbjct: 173 -------PVRLFWDCR---SLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINF 222
Query: 370 LH--RCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 427
H R L + LQ N+I + +L+ LDL+ N I++I F T+ +L L
Sbjct: 223 AHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKIL 282
Query: 428 DLTDNQLTTLP---LAGLGGLMHLKLKGNL 454
+ +N+L +L L L L + L GNL
Sbjct: 283 LMDNNKLNSLDSKILNSLRSLTTVGLSGNL 312
Score = 67.4 bits (163), Expect = 6e-11
Identities = 52/166 (31%), Positives = 75/166 (45%), Gaps = 4/166 (2%)
Query: 278 MGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEIL--TL 335
+G P+L I+ ++ + PK L D Q F + T L +L
Sbjct: 9 LGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSL 68
Query: 336 TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADT 393
I L +L L L HNQI + + KL+E+ L N+I+ + T
Sbjct: 69 RHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTT 128
Query: 394 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPL 439
F+QL +LQ LDLS+N + S+HPE F L L L L N L T+P+
Sbjct: 129 FTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPV 174
Score = 61.2 bits (147), Expect = 4e-09
Identities = 43/127 (33%), Positives = 62/127 (48%)
Query: 70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGI 129
+LDLS N L L F L L EL L N L+ I F L SL L LQ N++ +
Sbjct: 185 FLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNL 244
Query: 130 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQ 189
W +L+ L L N I + FE + +L+ L +D+N L + + LN+L +L
Sbjct: 245 TCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLT 304
Query: 190 AMTLALN 196
+ L+ N
Sbjct: 305 TVGLSGN 311
Score = 43.9 bits (102), Expect = 7e-04
Identities = 27/79 (34%), Positives = 43/79 (54%)
Query: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
L L N ++ L G+ LE+L L+GN + I F + +LKIL++ NN+L +
Sbjct: 234 LFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLD 293
Query: 131 AEALWELPSLQSLRLDANL 149
++ L L SL ++ L NL
Sbjct: 294 SKILNSLRSLTTVGLSGNL 312
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 125 bits (315), Expect = 1e-28
Identities = 84/263 (31%), Positives = 134/263 (50%), Gaps = 8/263 (3%)
Query: 58 SAVPGDLDPLT---AYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLY 114
S PG D L L L+ N ++ + P +F L L+ L L+ N + ++ G F GL
Sbjct: 121 SMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLG 179
Query: 115 SLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174
+LK L +Q N + + A W L +++ L+LD N ++ + + GL L+ L L NA+
Sbjct: 180 ALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAI 239
Query: 175 TEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLH 234
I A L + L N +S + D +F L+ L LH+ NNR+ ++ +F GL
Sbjct: 240 NRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLS 299
Query: 235 NLETLDLNYNK----LQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYD 290
+L+TLDL N+ +++ A L +L+ L N I++I +KAF G L+ + D
Sbjct: 300 SLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSD 359
Query: 291 NPIQFVGRSAFQYLPKLHTLSLN 313
N I + +AF + KL L LN
Sbjct: 360 NAIMSLQGNAFSQMKKLQQLHLN 382
Score = 123 bits (308), Expect = 9e-28
Identities = 113/374 (30%), Positives = 184/374 (49%), Gaps = 18/374 (4%)
Query: 72 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 131
DLS N L+ ++ HL+ L E++L+ N L IP ++ +L L N++ I
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIVEILP 78
Query: 132 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP-ALQA 190
E L E SL++L L +N IS + + +F L L++L+L+ N +T + +NL L
Sbjct: 79 EHLKEFQSLETLDLSSNNISEL-QTAFPALQ-LKYLYLNSNRVTSMEPGYFDNLANTLLV 136
Query: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF- 249
+ L NRIS IP F+ L L L L+ N+I+++ +F+GL L++L + N + +
Sbjct: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 250 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
A L ++ L +NN+ I + G +LQ +H N I + A+++ KL
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
Query: 310 LSLN----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI- 364
L L +D F G + L L + + + + L L+ L+L +N+I
Sbjct: 256 LDLTFNHLSRLDDSSF---LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEIS 312
Query: 365 ---EELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420
E++ + KL + LQ NRI I F+ L +L+ LDLS NAI S+ AFS
Sbjct: 313 WTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQ 372
Query: 421 LHSLVKLDLTDNQL 434
+ L +L L + L
Sbjct: 373 MKKLQQLHLNTSSL 386
Score = 85.5 bits (210), Expect = 2e-16
Identities = 81/294 (27%), Positives = 138/294 (46%), Gaps = 14/294 (4%)
Query: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228
L N L+ I ++++L +L+ + L N + IP+ + ++ +L L NRI +
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79
Query: 229 SFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAF--MGNPLLQTI 286
+ +LETLDL+ N + E A L +L+ L ++N + ++ F + N LL +
Sbjct: 80 HLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL-VL 137
Query: 287 HFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL--KGTTSLEILTLTRAGIRLLP 344
N I + F+ LP+L L LN I+ L +G +L+ L + R G+ L
Sbjct: 138 KLNRNRISAIPPKMFK-LPQLQHLELN-RNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195
Query: 345 SGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQA 402
G L + +L+L HN + E+ L+ L+E+ L N I I D + L
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255
Query: 403 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 453
LDL++N + + +F L L L + +N+++ + GL L L LK N
Sbjct: 256 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
Score = 57.4 bits (137), Expect = 6e-08
Identities = 66/245 (26%), Positives = 109/245 (44%), Gaps = 32/245 (13%)
Query: 217 LHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKA 276
L +NR+ + S L +L + LN N+L+ P LG + NI + +
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP----------NLGPVSANITLL---S 67
Query: 277 FMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE-FPDLKGTTSLEILTL 335
GN +++ + + FQ L L LS N ++Q FP L+ L+ L L
Sbjct: 68 LAGNRIVEILPEH--------LKEFQSLETLD-LSSNNISELQTAFPALQ----LKYLYL 114
Query: 336 TRAGIRLLPSGMCQQLPR-LRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADT 393
+ + G L L VL+L+ N+I +P + + +L+ + L N+I + T
Sbjct: 115 NSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLT 174
Query: 394 FSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453
F L +L++L + N + + AF L ++ L L N LT + L GL+ L+
Sbjct: 175 FQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQ---E 231
Query: 454 LALSQ 458
L LSQ
Sbjct: 232 LHLSQ 236
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 124 bits (310), Expect = 6e-28
Identities = 153/633 (24%), Positives = 270/633 (42%), Gaps = 89/633 (14%)
Query: 234 HNLETLDLNYNKLQEFPVAIRT-LGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNP 292
+N+ L L NK+ P + +L+++ +N I+ I KAF G LQ ++ N
Sbjct: 137 NNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNC 196
Query: 293 IQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDL-KGTTSLEILTLTRAGIRLLPSGMCQQL 351
I + F+ L +L L L+ + L G SL L++ + LP MC Q+
Sbjct: 197 ITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQM 256
Query: 352 PRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 411
P+L ++L N+I+ L + TF SL L L N I
Sbjct: 257 PQLNWVDLEGNRIKYLTN----------------------STFLSCDSLTVLFLPRNQIG 294
Query: 412 SIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRIL 471
+ + FS+L +L +LDL+ N +T L L +L L Q KL +
Sbjct: 295 FVPEKTFSSLKNLGELDLSSNTITELSP---------HLFKDLKLLQ--------KLNLS 337
Query: 472 EVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQ 531
P Y + + F++ Q ++ DL + + + + + Y ++
Sbjct: 338 SNPLMY------LHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCS 391
Query: 532 LEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVL---LTVFA 588
PH + C P E L + +R+ VW I ++ N V+ + A
Sbjct: 392 YA-----PHVRI-CMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKA 445
Query: 589 GGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFL 648
+K + A+ L G+ + D GQ+ +Y W + CR GFL
Sbjct: 446 ENTTHAMSIKI----LCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFL 501
Query: 649 AVLGSEASVLLLTLAAVQCSVSV----SCVRAYGKSPSLGSVRAGVLGCLALAG-LAAAL 703
A+L +E SVLLLT ++ + + S +R + S+ +L C+ +AG L A +
Sbjct: 502 AMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSV------ILICIWMAGFLIAVI 555
Query: 704 PLASV----GEYGASPLCLP-YAPPEGQPAALGFTVALVM-MNSFCFLVVAGAYIKLYCD 757
P + YG + +C P Y + G+++ + + +N FL++ +YI ++C
Sbjct: 556 PFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCS 615
Query: 758 LPRGDFEA--VWDC-----AMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPV-TPEAVK 809
+ + + V +C A+ +++F+D + + PV + +L LF V P+ +
Sbjct: 616 IQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVV---KILSLFRVEIPDTMT 672
Query: 810 S-VLLVVLPLPACLNPLLYLLFNPHFRDDLRRL 841
S +++ LP+ + LNP+LY L F+D L++L
Sbjct: 673 SWIVIFFLPVNSALNPILYTLTTNFFKDKLKQL 705
Score = 101 bits (251), Expect = 4e-21
Identities = 80/264 (30%), Positives = 123/264 (46%), Gaps = 7/264 (2%)
Query: 51 DCSELGLSAVPGDLDPL------TAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH 104
DC E L V GDL + L L N + L +F L+++ L N + H
Sbjct: 116 DCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRH 175
Query: 105 IPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSL 164
I +AF GL +L+IL L +N + + +L L L LD N I+ + +R F GL+SL
Sbjct: 176 ISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSL 235
Query: 165 RHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH 224
L + +N L +P + +P L + L NRI ++ + F + SL VL L N+I
Sbjct: 236 FFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGF 295
Query: 225 LGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLL 283
+ +F L NL LDL+ N + E P + L LQ+L +N + + + F L
Sbjct: 296 VPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQL 355
Query: 284 QTIHFYDNPIQFVGRSAFQYLPKL 307
Q++ I + FQ + L
Sbjct: 356 QSLDLERIEIPNINTRMFQPMKNL 379
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 120 bits (300), Expect = 8e-27
Identities = 113/370 (30%), Positives = 167/370 (45%), Gaps = 44/370 (11%)
Query: 119 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTE 176
L LQNNQL +P L L L++L L NLIS +P+ +FE L+ L+HL + N L+
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 136
Query: 177 IPVRALNNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT--HSFEGL 233
P LP +L+ LA N++ I F +L ++LHNN++ + G +F G
Sbjct: 137 AP----QFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 192
Query: 234 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 293
+ TL L+ N+L P ++ L+ L NN I +P A L+ ++ N +
Sbjct: 193 EAIATLSLSNNQLSYLPPSLPP--SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 250
Query: 294 QFVGRSAFQYLPKLHTLSLNGAMDIQ-------------------------EFPDLKGTT 328
G A + KLH+L Q E L G
Sbjct: 251 TDSGLDATTF-SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGAR 309
Query: 329 SLEILTL--TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNR 385
L L L + G LP+G + L L L L N ++ +P +L R +L + L HN
Sbjct: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNH 367
Query: 386 IWEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG 443
+ +GA L L+L++N + S +H AF L +L LDL NQLT LP+
Sbjct: 368 VAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPT 427
Query: 444 GLMHLKLKGN 453
GL L+L+ N
Sbjct: 428 GLRTLQLQRN 437
Score = 108 bits (270), Expect = 2e-23
Identities = 119/438 (27%), Positives = 184/438 (42%), Gaps = 46/438 (10%)
Query: 30 PGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHL 89
P P ACP C C + + DC L L P ++ +L L N L EL L
Sbjct: 39 PLPRACPLRCSCPR---VDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRL 95
Query: 90 RFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGIP-------------AEAL 134
L L L N +S +P +AF L L+ L + +N+L P A +
Sbjct: 96 SGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQV 155
Query: 135 WEL--------PSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTEIPVRALNN 184
E+ P+L+S+ L N +S +P +F G ++ L L +N L+ +P
Sbjct: 156 MEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLP-- 213
Query: 185 LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHS--FEGLHNLETLDLN 242
P+L+ + L N IS +P A T L L+L +N++ G + F LH+LE LDL+
Sbjct: 214 -PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLS 272
Query: 243 YNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG--RSA 300
+N+L P + + LG N I+ + G L+ + N + G A
Sbjct: 273 HNQLTTVPAGLPRTLAILHLG--RNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGA 330
Query: 301 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
+ L LHTL L G + P L L L L + L + P L L L+
Sbjct: 331 LRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAALGARDLVATPGLTELNLA 388
Query: 361 HNQIEELPSLHRC----QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
+N++ HR + L + L N++ + + L+ L L N +R + PE
Sbjct: 389 YNRLASARVHHRAFRRLRALRSLDLAGNQLTRL---PMGLPTGLRTLQLQRNQLRMLEPE 445
Query: 417 AFSTLHSLVKLDLTDNQL 434
+ L L +L L N+L
Sbjct: 446 PLAGLDQLRELSLAHNRL 463
Score = 75.9 bits (185), Expect = 2e-13
Identities = 70/206 (33%), Positives = 97/206 (47%), Gaps = 14/206 (6%)
Query: 70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG-- 127
YLDLS N LT + GL R L L L N + + G L+ L+LQ+NQLG
Sbjct: 268 YLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSS 324
Query: 128 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 187
G+PA AL L L +L L N + VP LR L L N + + R L P
Sbjct: 325 GLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPG 381
Query: 188 LQAMTLALNRI--SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 245
L + LA NR+ + + AF+ L +L L L N++ L G L TL L N+
Sbjct: 382 LTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG---LRTLQLQRNQ 438
Query: 246 LQEF-PVAIRTLGRLQELGFHNNNIK 270
L+ P + L +L+EL +N ++
Sbjct: 439 LRMLEPEPLAGLDQLRELSLAHNRLR 464
Score = 44.3 bits (103), Expect = 6e-04
Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 35/220 (15%)
Query: 305 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
P++ T+ +G +D++ FPD T + + L+L ++ LP +L LR L L +N I
Sbjct: 51 PRVDTVDCDG-LDLRVFPD-NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 108
Query: 365 --EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420
E LP + +L+ + + HN++ + + SL+ DL+ N + I P F
Sbjct: 109 SSEGLPDEAFESLTQLQHLCVAHNKL-SVAPQFLPR--SLRVADLAANQVMEIFPLTFGE 165
Query: 421 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
+L + L +NQL+ GL +G+ A++ ++ ++ Y
Sbjct: 166 KPALRSVYLHNNQLSN------AGLPPDAFRGSEAIATLSLSNN-------QLSYLPPSL 212
Query: 481 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE 520
P + E LHL + SK P G L+RQ +
Sbjct: 213 PPSL-------------ERLHLQNNLISKVPRGALSRQTQ 239
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 120 bits (300), Expect = 8e-27
Identities = 113/370 (30%), Positives = 167/370 (45%), Gaps = 44/370 (11%)
Query: 119 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTE 176
L LQNNQL +P L L L++L L NLIS +P+ +FE L+ L+HL + N L+
Sbjct: 79 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSV 138
Query: 177 IPVRALNNLP-ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT--HSFEGL 233
P LP +L+ LA N++ I F +L ++LHNN++ + G +F G
Sbjct: 139 AP----QFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGS 194
Query: 234 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI 293
+ TL L+ N+L P ++ L+ L NN I +P A L+ ++ N +
Sbjct: 195 EAIATLSLSNNQLSYLPPSLPP--SLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQL 252
Query: 294 QFVGRSAFQYLPKLHTLSLNGAMDIQ-------------------------EFPDLKGTT 328
G A + KLH+L Q E L G
Sbjct: 253 TDSGLDATTF-SKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGAR 311
Query: 329 SLEILTL--TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNR 385
L L L + G LP+G + L L L L N ++ +P +L R +L + L HN
Sbjct: 312 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNH 369
Query: 386 IWEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG 443
+ +GA L L+L++N + S +H AF L +L LDL NQLT LP+
Sbjct: 370 VAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPT 429
Query: 444 GLMHLKLKGN 453
GL L+L+ N
Sbjct: 430 GLRTLQLQRN 439
Score = 108 bits (270), Expect = 2e-23
Identities = 119/438 (27%), Positives = 184/438 (42%), Gaps = 46/438 (10%)
Query: 30 PGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHL 89
P P ACP C C + + DC L L P ++ +L L N L EL L
Sbjct: 41 PLPRACPLRCSCPR---VDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRL 97
Query: 90 RFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGIP-------------AEAL 134
L L L N +S +P +AF L L+ L + +N+L P A +
Sbjct: 98 SGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQV 157
Query: 135 WEL--------PSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTEIPVRALNN 184
E+ P+L+S+ L N +S +P +F G ++ L L +N L+ +P
Sbjct: 158 MEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLP-- 215
Query: 185 LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHS--FEGLHNLETLDLN 242
P+L+ + L N IS +P A T L L+L +N++ G + F LH+LE LDL+
Sbjct: 216 -PSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLS 274
Query: 243 YNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVG--RSA 300
+N+L P + + LG N I+ + G L+ + N + G A
Sbjct: 275 HNQLTTVPAGLPRTLAILHLG--RNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGA 332
Query: 301 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
+ L LHTL L G + P L L L L + L + P L L L+
Sbjct: 333 LRPLRGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAALGARDLVATPGLTELNLA 390
Query: 361 HNQIEELPSLHRC----QKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
+N++ HR + L + L N++ + + L+ L L N +R + PE
Sbjct: 391 YNRLASARVHHRAFRRLRALRSLDLAGNQLTRL---PMGLPTGLRTLQLQRNQLRMLEPE 447
Query: 417 AFSTLHSLVKLDLTDNQL 434
+ L L +L L N+L
Sbjct: 448 PLAGLDQLRELSLAHNRL 465
Score = 75.9 bits (185), Expect = 2e-13
Identities = 70/206 (33%), Positives = 97/206 (47%), Gaps = 14/206 (6%)
Query: 70 YLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG-- 127
YLDLS N LT + GL R L L L N + + G L+ L+LQ+NQLG
Sbjct: 270 YLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSS 326
Query: 128 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 187
G+PA AL L L +L L N + VP LR L L N + + R L P
Sbjct: 327 GLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGARDLVATPG 383
Query: 188 LQAMTLALNRI--SHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 245
L + LA NR+ + + AF+ L +L L L N++ L G L TL L N+
Sbjct: 384 LTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTG---LRTLQLQRNQ 440
Query: 246 LQEF-PVAIRTLGRLQELGFHNNNIK 270
L+ P + L +L+EL +N ++
Sbjct: 441 LRMLEPEPLAGLDQLRELSLAHNRLR 466
Score = 44.3 bits (103), Expect = 6e-04
Identities = 55/220 (25%), Positives = 97/220 (44%), Gaps = 35/220 (15%)
Query: 305 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
P++ T+ +G +D++ FPD T + + L+L ++ LP +L LR L L +N I
Sbjct: 53 PRVDTVDCDG-LDLRVFPD-NITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 110
Query: 365 --EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST 420
E LP + +L+ + + HN++ + + SL+ DL+ N + I P F
Sbjct: 111 SSEGLPDEAFESLTQLQHLCVAHNKL-SVAPQFLPR--SLRVADLAANQVMEIFPLTFGE 167
Query: 421 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC 480
+L + L +NQL+ GL +G+ A++ ++ ++ Y
Sbjct: 168 KPALRSVYLHNNQLSN------AGLPPDAFRGSEAIATLSLSNN-------QLSYLPPSL 214
Query: 481 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE 520
P + E LHL + SK P G L+RQ +
Sbjct: 215 PPSL-------------ERLHLQNNLISKVPRGALSRQTQ 241
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 120 bits (300), Expect = 8e-27
Identities = 120/410 (29%), Positives = 170/410 (41%), Gaps = 64/410 (15%)
Query: 8 RALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGL------SAVP 61
RAL L +C G P CP C CQ +L C+ GL S++P
Sbjct: 5 RALRLLLVVC-----GCLALPPLAEPVCPERCDCQHPQHLL---CTNRGLRVVPKTSSLP 56
Query: 62 GDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILML 121
D LT L N +T + FH L L L L N + + + F L L+ L L
Sbjct: 57 SPHDVLT--YSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYL 114
Query: 122 QNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRA 181
NN L + L L L+ L + N IS + SFEGL SL L LD NAL
Sbjct: 115 GNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNAL------- 167
Query: 182 LNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDL 241
+PD F L +L+ LHL +NRI+ LG ++F L L L+L
Sbjct: 168 -----------------GALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNL 210
Query: 242 NYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAF 301
+ N+LQ T L+ L ++ N +Q +G F
Sbjct: 211 SANELQPSLRHAATFAPLRS---------------------LSSLILSANNLQHLGPRIF 249
Query: 302 QYLPKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS 360
Q+LP+L LSL G P+ G +L L L + LP+ + + L L L+LS
Sbjct: 250 QHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLS 309
Query: 361 HNQIEEL--PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 408
N++ L + +L E+ L++N + + D F+ +L LDL N
Sbjct: 310 GNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 108 bits (269), Expect = 3e-23
Identities = 92/297 (30%), Positives = 140/297 (47%), Gaps = 15/297 (5%)
Query: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228
L N +T I + L L+ + L N+I + F+ L+ L L+L NN +Q L
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 229 SFEGLHNLETLDLNYNKLQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH 287
+ L L L N N++ + L L +L N + A+P+ F L +H
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
Query: 288 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTT------SLEILTLTRAGIR 341
N I+F+G++AF L KL L+L+ A ++Q P L+ SL L L+ ++
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLS-ANELQ--PSLRHAATFAPLRSLSSLILSANNLQ 242
Query: 342 LLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSS 399
L + Q LPRL +L L NQ+ L + + L E+ L+ NR+ ++ L S
Sbjct: 243 HLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHS 302
Query: 400 LQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 453
L+ALDLS N + ++HP F L L +L L +N L+ L A L L L GN
Sbjct: 303 LEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 58.9 bits (141), Expect = 2e-08
Identities = 40/110 (36%), Positives = 49/110 (44%)
Query: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125
P L L N LT L P F L L ELRL GN LS +P L+SL+ L L N+
Sbjct: 253 PRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNE 312
Query: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALT 175
L + L L+ L L N +S + F +L L LD N T
Sbjct: 313 LSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWT 362
Score = 45.1 bits (105), Expect = 3e-04
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 367 LPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVK 426
LPS H + L N I I A F +L L+ LDL +N IRS+HP+ F L L +
Sbjct: 55 LPSPH---DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEE 111
Query: 427 LDLTDNQLTTLPLAGLGGLMHLKL 450
L L +N L L L L L++
Sbjct: 112 LYLGNNLLQALAPGTLAPLRKLRI 135
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,515,550
Number of Sequences: 37866
Number of extensions: 2158701
Number of successful extensions: 12708
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 245
Number of HSP's successfully gapped in prelim test: 117
Number of HSP's that attempted gapping in prelim test: 7855
Number of HSP's gapped (non-prelim): 1840
length of query: 967
length of database: 18,247,518
effective HSP length: 112
effective length of query: 855
effective length of database: 14,006,526
effective search space: 11975579730
effective search space used: 11975579730
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.