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Search of human proteins with 62241001
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo
sapiens]
(745 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo s... 1512 0.0
gi|41352712 inhibitor of nuclear factor kappa B kinase beta subu... 731 0.0
gi|7661946 IKK-related kinase epsilon [Homo sapiens] 133 5e-31
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 129 1e-29
gi|7019547 TANK-binding kinase 1 [Homo sapiens] 128 2e-29
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 123 5e-28
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 123 5e-28
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 113 7e-25
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 112 1e-24
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 112 1e-24
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 112 1e-24
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 112 1e-24
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ... 112 1e-24
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ... 112 1e-24
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ... 112 1e-24
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 112 2e-24
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 110 4e-24
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 110 4e-24
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 110 4e-24
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 110 4e-24
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 110 4e-24
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 109 8e-24
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 108 2e-23
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 108 2e-23
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 108 2e-23
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 107 3e-23
gi|14670383 death-associated kinase 2 [Homo sapiens] 107 4e-23
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 107 4e-23
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 107 4e-23
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 107 5e-23
>gi|62241001 conserved helix-loop-helix ubiquitous kinase [Homo
sapiens]
Length = 745
Score = 1512 bits (3915), Expect = 0.0
Identities = 745/745 (100%), Positives = 745/745 (100%)
Query: 1 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH 60
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
Sbjct: 1 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH 60
Query: 61 EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ 120
EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
Sbjct: 61 EIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ 120
Query: 121 ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS 180
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS
Sbjct: 121 ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTS 180
Query: 181 FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK 240
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
Sbjct: 181 FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK 240
Query: 241 CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC 300
CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
Sbjct: 241 CIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC 300
Query: 301 FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI 360
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI
Sbjct: 301 FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGI 360
Query: 361 SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI 420
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
Sbjct: 361 SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI 420
Query: 421 IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL 480
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
Sbjct: 421 IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL 480
Query: 481 EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE 540
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE
Sbjct: 481 EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAE 540
Query: 541 IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV 600
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
Sbjct: 541 IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV 600
Query: 601 LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ 660
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
Sbjct: 601 LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ 660
Query: 661 SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL 720
SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL
Sbjct: 661 SSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHL 720
Query: 721 STIIHEANEEQGNSMMNLDWSWLTE 745
STIIHEANEEQGNSMMNLDWSWLTE
Sbjct: 721 STIIHEANEEQGNSMMNLDWSWLTE 745
>gi|41352712 inhibitor of nuclear factor kappa B kinase beta subunit
[Homo sapiens]
Length = 756
Score = 731 bits (1887), Expect = 0.0
Identities = 383/749 (51%), Positives = 510/749 (68%), Gaps = 13/749 (1%)
Query: 1 MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH 60
M P L G WEM+ERLGTGGFGNV + ++E +IAIK CR ELS +NRERWC
Sbjct: 1 MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL 60
Query: 61 EIQIMKKLNHANVVKACDVPEEL-NILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKES 119
EIQIM++L H NVV A DVPE + N+ +D+PLLAMEYC GGDLRK LN+ ENCCGL+E
Sbjct: 61 EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG 120
Query: 120 QILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCT 179
IL+LLSDI S +RYLHEN+IIHRDLKPENIVLQ ++IHKIIDLGYAK++DQGSLCT
Sbjct: 121 AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT 180
Query: 180 SFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDP 239
SFVGTLQYLAPEL E + YT TVDYWSFGT+ FECI G+RPFL + QP WH K+++K
Sbjct: 181 SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE 240
Query: 240 KCIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPR 299
I E+++G V+FSS LP PN+L S++ E +E WLQLML W P+QRG D T
Sbjct: 241 VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRG--TDPTYGPNG 298
Query: 300 CFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETG 359
CF +D ILNLK+VHILNM + I ++ + DESL SL++RI+++TGI QELL E G
Sbjct: 299 CFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAG 358
Query: 360 ISLDPRKPASQCVLDGV----RGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSK 415
++L P KPA+QC+ DG D +V+LFD SK YE + R + V+ I+Q+ K
Sbjct: 359 LALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPK 418
Query: 416 IQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQ 475
L QLRKVW + H + LKED +RL QGQRAAM++LLR N+ L+KMKN++ S SQQ
Sbjct: 419 RNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQ 478
Query: 476 LKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIM 535
LKAKL+FF SIQ+DLE+YSEQ +GI+S+K+L AW+EME+ + L +++M
Sbjct: 479 LKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMM 538
Query: 536 SLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSD-HSYSDSTEMVKIIVHTV 594
+L +I++LQ+SP GR+QG ++ LE++A +LY++L+ +P D + DS EMV++++ +
Sbjct: 539 ALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAI 598
Query: 595 QSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLL 654
QS ++ ++ ++ LSK + CKQK ++LLPKVE +S + E + TV+ +Q KRQKE+W+LL
Sbjct: 599 QSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLL 658
Query: 655 KIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENL 714
KIAC S R V S + + S P S + P+ + S +++ E
Sbjct: 659 KIAC--SKVRGPVSGSPDSMNASRLS---QPGQLMSQPSTASNSLPEPAKKSEELVAEAH 713
Query: 715 NCLGHLSTIIHEANEEQGNSMMNLDWSWL 743
N L I + EQ S LDWSWL
Sbjct: 714 NLCTLLENAIQDTVREQDQSFTALDWSWL 742
>gi|7661946 IKK-related kinase epsilon [Homo sapiens]
Length = 716
Score = 133 bits (335), Expect = 5e-31
Identities = 100/363 (27%), Positives = 165/363 (45%), Gaps = 36/363 (9%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 74
W + LG G +V ++++ +A+K + RE E ++++KLNH N+V
Sbjct: 9 WHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIV 68
Query: 75 KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY 134
K V E +L MEYCS G L +L PEN GL E + L +L + +G+ +
Sbjct: 69 KLFAVEETGG---SRQKVLVMEYCSSGSLLSVLESPENAFGLPEDEFLVVLRCVVAGMNH 125
Query: 135 LHENKIIHRDLKPENIV-LQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF 193
L EN I+HRD+KP NI+ L G+ I+K+ D G A+++D S GT +YL P+++
Sbjct: 126 LRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMY 185
Query: 194 E--------NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHE---KIKKKDPKCI 242
E K + TVD WS G ++ G PF+ P E +I + P
Sbjct: 186 ERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGA 245
Query: 243 FACEEM--SGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC 300
A + +G + +S LP C L + + ++ N L ++Q +C
Sbjct: 246 IAGAQRRENGPLEWSYTLP---ITCQLSLGLQSQLVPILAN----------ILEVEQAKC 292
Query: 301 ------FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQEL 354
F IL +VH+ +++ A + + ++ Q + ++T + QE
Sbjct: 293 WGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEY 352
Query: 355 LSE 357
L E
Sbjct: 353 LFE 355
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 129 bits (324), Expect = 1e-29
Identities = 79/229 (34%), Positives = 117/229 (51%), Gaps = 22/229 (9%)
Query: 7 LRPGAGGP-------WEMRERLGTGGFGNVCLYQHREL-DLKIAIKSCRLELSTKNRERW 58
+ PG GG + ++ +G G F V +HRE DL++A+K + K++
Sbjct: 1 MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL 60
Query: 59 CHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKE 118
EI+I+K+L H N+V D E N + L MEYC+GGDL L+ L E
Sbjct: 61 GKEIKILKELKHENIVALYDFQEMANSVY-----LVMEYCNGGDLADYLHAMRT---LSE 112
Query: 119 SQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGK------IIHKIIDLGYAKDV 172
I L I +R LH IIHRDLKP+NI+L + G+ I KI D G+A+ +
Sbjct: 113 DTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYL 172
Query: 173 DQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPF 221
+ + G+ Y+APE+ ++ Y D WS GT+V++C+ G PF
Sbjct: 173 QSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPF 221
>gi|7019547 TANK-binding kinase 1 [Homo sapiens]
Length = 729
Score = 128 bits (321), Expect = 2e-29
Identities = 106/365 (29%), Positives = 170/365 (46%), Gaps = 40/365 (10%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 74
W + + LG G NV +H++ AIK + + E +++KKLNH N+V
Sbjct: 9 WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV 68
Query: 75 KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY 134
K + EE H V L ME+C G L +L +P N GL ES+ L +L D+ G+ +
Sbjct: 69 KLFAIEEETTTR-HKV--LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH 125
Query: 135 LHENKIIHRDLKPENIVLQDVG--GKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPEL 192
L EN I+HRD+KP NI ++ +G G+ ++K+ D G A++++ S GT +YL P++
Sbjct: 126 LRENGIVHRDIKPGNI-MRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184
Query: 193 FE--------NKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIF- 243
+E K Y ATVD WS G + G PF +PF + K+ K I
Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF----RPFEGPRRNKEVMYKIITG 240
Query: 244 --------ACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTL 295
+ +G + +S +P SL + + L +L D ++ G
Sbjct: 241 KPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWG------ 294
Query: 296 KQPRCFVLMDHILNLKIVHILN---MTSAKIISFLLPPDESLHSLQSRIERETGINTGSQ 352
+ F IL+ ++H+ + MT+ KI H L + ++T I + +Q
Sbjct: 295 -FDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHEL---VYKQTKIISSNQ 350
Query: 353 ELLSE 357
EL+ E
Sbjct: 351 ELIYE 355
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 123 bits (309), Expect = 5e-28
Identities = 76/214 (35%), Positives = 113/214 (52%), Gaps = 15/214 (7%)
Query: 15 WEMRERLGTGGFGNVCLYQHRE-LDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANV 73
+ R+ +G G F V +HR+ D ++AIKS + +K++ EI+I+K+L H N+
Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI 68
Query: 74 VKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 133
V DV E N + L MEYC+GGDL L L E I L I + +R
Sbjct: 69 VALYDVQELPNSVF-----LVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQIAAAMR 120
Query: 134 YLHENKIIHRDLKPENIVLQDVGGK------IIHKIIDLGYAKDVDQGSLCTSFVGTLQY 187
LH IIHRDLKP+NI+L + I KI D G+A+ + + + G+ Y
Sbjct: 121 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY 180
Query: 188 LAPELFENKPYTATVDYWSFGTMVFECIAGYRPF 221
+APE+ ++ Y A D WS GT++++C+ G PF
Sbjct: 181 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPF 214
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 123 bits (309), Expect = 5e-28
Identities = 76/214 (35%), Positives = 113/214 (52%), Gaps = 15/214 (7%)
Query: 15 WEMRERLGTGGFGNVCLYQHRE-LDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANV 73
+ R+ +G G F V +HR+ D ++AIKS + +K++ EI+I+K+L H N+
Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI 68
Query: 74 VKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 133
V DV E N + L MEYC+GGDL L L E I L I + +R
Sbjct: 69 VALYDVQELPNSVF-----LVMEYCNGGDLADYLQAKGT---LSEDTIRVFLHQIAAAMR 120
Query: 134 YLHENKIIHRDLKPENIVLQDVGGK------IIHKIIDLGYAKDVDQGSLCTSFVGTLQY 187
LH IIHRDLKP+NI+L + I KI D G+A+ + + + G+ Y
Sbjct: 121 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMY 180
Query: 188 LAPELFENKPYTATVDYWSFGTMVFECIAGYRPF 221
+APE+ ++ Y A D WS GT++++C+ G PF
Sbjct: 181 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPF 214
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 113 bits (282), Expect = 7e-25
Identities = 70/211 (33%), Positives = 113/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + +++ +G G F V L +H ++A+K + +L+ + ++ E++IMK LNH
Sbjct: 58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 117
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + + I S
Sbjct: 118 NIVKLFEVIETEKTLY-----LVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSA 169
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ I+HRDLK EN++L G + KI D G++ + G+ +F G+ Y APE
Sbjct: 170 VQYCHQKYIVHRDLKAENLLLD---GDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPE 226
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 227 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 257
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 112 bits (280), Expect = 1e-24
Identities = 73/211 (34%), Positives = 112/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++AIK + +L+ + ++ E++IMK LNH
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + S I S
Sbjct: 114 NIVKLFEVIETEKTLY-----LIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSA 165
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ +I+HRDLK EN++L D I KI D G++ + G +F G+ Y APE
Sbjct: 166 VQYCHQKRIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTVGGKLDTFCGSPPYAAPE 222
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 223 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 112 bits (280), Expect = 1e-24
Identities = 73/211 (34%), Positives = 112/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++AIK + +L+ + ++ E++IMK LNH
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + S I S
Sbjct: 114 NIVKLFEVIETEKTLY-----LIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSA 165
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ +I+HRDLK EN++L D I KI D G++ + G +F G+ Y APE
Sbjct: 166 VQYCHQKRIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTVGGKLDTFCGSPPYAAPE 222
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 223 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 112 bits (280), Expect = 1e-24
Identities = 73/211 (34%), Positives = 112/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++AIK + +L+ + ++ E++IMK LNH
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + S I S
Sbjct: 114 NIVKLFEVIETEKTLY-----LIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSA 165
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ +I+HRDLK EN++L D I KI D G++ + G +F G+ Y APE
Sbjct: 166 VQYCHQKRIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTVGGKLDTFCGSPPYAAPE 222
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 223 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 112 bits (280), Expect = 1e-24
Identities = 73/211 (34%), Positives = 112/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++AIK + +L+ + ++ E++IMK LNH
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + S I S
Sbjct: 114 NIVKLFEVIETEKTLY-----LIMEYASGGEVFDYLVAHGR---MKEKEARSKFRQIVSA 165
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ +I+HRDLK EN++L D I KI D G++ + G +F G+ Y APE
Sbjct: 166 VQYCHQKRIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTVGGKLDTFCGSPPYAAPE 222
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 223 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 253
>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
sapiens]
Length = 560
Score = 112 bits (280), Expect = 1e-24
Identities = 86/257 (33%), Positives = 127/257 (49%), Gaps = 22/257 (8%)
Query: 21 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC--HEIQIMKKLNHANVVKACD 78
LG GGFG VC Q R A K + K + +E QI++K+N VV
Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251
Query: 79 VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHEN 138
E + L L + +GGDL+ + G E++ + ++I G+ LH
Sbjct: 252 AYETKDALC-----LVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRE 305
Query: 139 KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPY 198
+I++RDLKPENI+L D G +I DLG A V +G VGT+ Y+APE+ +N+ Y
Sbjct: 306 RIVYRDLKPENILLDDHGHI---RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY 362
Query: 199 TATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHL 258
T + D+W+ G +++E IAG PF +KIK+++ + + RFS
Sbjct: 363 TFSPDWWALGCLLYEMIAGQSPFQQR------KKKIKREEVERLVKEVPEEYSERFS--- 413
Query: 259 PQPNSLCS--LVVEPME 273
PQ SLCS L +P E
Sbjct: 414 PQARSLCSQLLCKDPAE 430
>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
sapiens]
Length = 576
Score = 112 bits (280), Expect = 1e-24
Identities = 86/257 (33%), Positives = 127/257 (49%), Gaps = 22/257 (8%)
Query: 21 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC--HEIQIMKKLNHANVVKACD 78
LG GGFG VC Q R A K + K + +E QI++K+N VV
Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251
Query: 79 VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHEN 138
E + L L + +GGDL+ + G E++ + ++I G+ LH
Sbjct: 252 AYETKDALC-----LVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRE 305
Query: 139 KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPY 198
+I++RDLKPENI+L D G +I DLG A V +G VGT+ Y+APE+ +N+ Y
Sbjct: 306 RIVYRDLKPENILLDDHGHI---RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY 362
Query: 199 TATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHL 258
T + D+W+ G +++E IAG PF +KIK+++ + + RFS
Sbjct: 363 TFSPDWWALGCLLYEMIAGQSPFQQR------KKKIKREEVERLVKEVPEEYSERFS--- 413
Query: 259 PQPNSLCS--LVVEPME 273
PQ SLCS L +P E
Sbjct: 414 PQARSLCSQLLCKDPAE 430
>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
sapiens]
Length = 589
Score = 112 bits (280), Expect = 1e-24
Identities = 86/257 (33%), Positives = 127/257 (49%), Gaps = 22/257 (8%)
Query: 21 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC--HEIQIMKKLNHANVVKACD 78
LG GGFG VC Q R A K + K + +E QI++K+N VV
Sbjct: 192 LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAY 251
Query: 79 VPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHEN 138
E + L L + +GGDL+ + G E++ + ++I G+ LH
Sbjct: 252 AYETKDALC-----LVLTLMNGGDLKFHIYHMGQA-GFPEARAVFYAAEICCGLEDLHRE 305
Query: 139 KIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPY 198
+I++RDLKPENI+L D G +I DLG A V +G VGT+ Y+APE+ +N+ Y
Sbjct: 306 RIVYRDLKPENILLDDHGHI---RISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY 362
Query: 199 TATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHL 258
T + D+W+ G +++E IAG PF +KIK+++ + + RFS
Sbjct: 363 TFSPDWWALGCLLYEMIAGQSPFQQR------KKKIKREEVERLVKEVPEEYSERFS--- 413
Query: 259 PQPNSLCS--LVVEPME 273
PQ SLCS L +P E
Sbjct: 414 PQARSLCSQLLCKDPAE 430
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 112 bits (279), Expect = 2e-24
Identities = 73/214 (34%), Positives = 110/214 (51%), Gaps = 13/214 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + +G G F V L +H ++AIK + +L+ + ++ E++IMK LNH
Sbjct: 57 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 116
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY S G++ L +KE + + I S
Sbjct: 117 NIVKLFEVIETEKTLY-----LVMEYASAGEVFDYLVSHGR---MKEKEARAKFRQIVSA 168
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
+ Y H+ I+HRDLK EN++L D I KI D G++ + GS +F G+ Y APE
Sbjct: 169 VHYCHQKNIVHRDLKAENLLL-DAEANI--KIADFGFSNEFTLGSKLDTFCGSPPYAAPE 225
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPFLHH 224
LF+ K Y VD WS G +++ ++G PF H
Sbjct: 226 LFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGH 259
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 110 bits (276), Expect = 4e-24
Identities = 71/211 (33%), Positives = 113/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++A+K + +L++ + ++ E++IMK LNH
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + + I S
Sbjct: 111 NIVKLFEVIETEKTLY-----LVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSA 162
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ I+HRDLK EN++L D I KI D G++ + G+ +F G+ Y APE
Sbjct: 163 VQYCHQKFIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTFGNKLDTFCGSPPYAAPE 219
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 110 bits (276), Expect = 4e-24
Identities = 71/211 (33%), Positives = 113/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++A+K + +L++ + ++ E++IMK LNH
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + + I S
Sbjct: 111 NIVKLFEVIETEKTLY-----LVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSA 162
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ I+HRDLK EN++L D I KI D G++ + G+ +F G+ Y APE
Sbjct: 163 VQYCHQKFIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTFGNKLDTFCGSPPYAAPE 219
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 110 bits (276), Expect = 4e-24
Identities = 71/211 (33%), Positives = 113/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++A+K + +L++ + ++ E++IMK LNH
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + + I S
Sbjct: 111 NIVKLFEVIETEKTLY-----LVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSA 162
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ I+HRDLK EN++L D I KI D G++ + G+ +F G+ Y APE
Sbjct: 163 VQYCHQKFIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTFGNKLDTFCGSPPYAAPE 219
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 110 bits (276), Expect = 4e-24
Identities = 71/211 (33%), Positives = 113/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++A+K + +L++ + ++ E++IMK LNH
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 110
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + + I S
Sbjct: 111 NIVKLFEVIETEKTLY-----LVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSA 162
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ I+HRDLK EN++L D I KI D G++ + G+ +F G+ Y APE
Sbjct: 163 VQYCHQKFIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTFGNKLDTFCGSPPYAAPE 219
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 220 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 250
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 110 bits (276), Expect = 4e-24
Identities = 71/211 (33%), Positives = 113/211 (53%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + + + +G G F V L +H ++A+K + +L++ + ++ E++IMK LNH
Sbjct: 18 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 77
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+VK +V E L L MEY SGG++ L +KE + + I S
Sbjct: 78 NIVKLFEVIETEKTLY-----LVMEYASGGEVFDYLVAHGR---MKEKEARAKFRQIVSA 129
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++Y H+ I+HRDLK EN++L D I KI D G++ + G+ +F G+ Y APE
Sbjct: 130 VQYCHQKFIVHRDLKAENLLL-DADMNI--KIADFGFSNEFTFGNKLDTFCGSPPYAAPE 186
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPF 221
LF+ K Y VD WS G +++ ++G PF
Sbjct: 187 LFQGKKYDGPEVDVWSLGVILYTLVSGSLPF 217
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 109 bits (273), Expect = 8e-24
Identities = 65/209 (31%), Positives = 108/209 (51%), Gaps = 10/209 (4%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLE-LSTKNRERWCHEIQIMKKLNHANV 73
+++ + +G G FG L + + IK E + + +E E+ +++K+ H N+
Sbjct: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNI 63
Query: 74 VKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 133
V + +E L + MEYC GGDL K +N+ E QIL I G++
Sbjct: 64 VAFFNSFQENGRLF-----IVMEYCDGGDLMKRINRQRGVL-FSEDQILGWFVQISLGLK 117
Query: 134 YLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQG-SLCTSFVGTLQYLAPEL 192
++H+ KI+HRD+K +NI L G ++ K+ D G A+ ++ L + +GT YL+PE+
Sbjct: 118 HIHDRKILHRDIKAQNIFLSKNG--MVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEI 175
Query: 193 FENKPYTATVDYWSFGTMVFECIAGYRPF 221
+NKPY D WS G +++E PF
Sbjct: 176 CQNKPYNNKTDIWSLGCVLYELCTLKHPF 204
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 108 bits (270), Expect = 2e-23
Identities = 72/211 (34%), Positives = 111/211 (52%), Gaps = 16/211 (7%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC-HEIQIMKKLNHANV 73
+E +E LGTG F V L + + A+K C + + K +E +EI +++K+ H N+
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVK-CIPKKALKGKESSIENEIAVLRKIKHENI 81
Query: 74 VKACDVPEELNILIHDVPLLAMEYCSGGDL-RKLLNKPENCCGLKESQILSLLSDIGSGI 132
V D+ E N L L M+ SGG+L +++ K E +L+ + +
Sbjct: 82 VALEDIYESPNHLY-----LVMQLVSGGELFDRIVEKGF----YTEKDASTLIRQVLDAV 132
Query: 133 RYLHENKIIHRDLKPENIVL--QDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAP 190
YLH I+HRDLKPEN++ QD KI+ I D G +K +G + ++ GT Y+AP
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIM--ISDFGLSKMEGKGDVMSTACGTPGYVAP 190
Query: 191 ELFENKPYTATVDYWSFGTMVFECIAGYRPF 221
E+ KPY+ VD WS G + + + GY PF
Sbjct: 191 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPF 221
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 108 bits (270), Expect = 2e-23
Identities = 72/211 (34%), Positives = 111/211 (52%), Gaps = 16/211 (7%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC-HEIQIMKKLNHANV 73
+E +E LGTG F V L + + A+K C + + K +E +EI +++K+ H N+
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVK-CIPKKALKGKESSIENEIAVLRKIKHENI 81
Query: 74 VKACDVPEELNILIHDVPLLAMEYCSGGDL-RKLLNKPENCCGLKESQILSLLSDIGSGI 132
V D+ E N L L M+ SGG+L +++ K E +L+ + +
Sbjct: 82 VALEDIYESPNHLY-----LVMQLVSGGELFDRIVEKGF----YTEKDASTLIRQVLDAV 132
Query: 133 RYLHENKIIHRDLKPENIVL--QDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAP 190
YLH I+HRDLKPEN++ QD KI+ I D G +K +G + ++ GT Y+AP
Sbjct: 133 YYLHRMGIVHRDLKPENLLYYSQDEESKIM--ISDFGLSKMEGKGDVMSTACGTPGYVAP 190
Query: 191 ELFENKPYTATVDYWSFGTMVFECIAGYRPF 221
E+ KPY+ VD WS G + + + GY PF
Sbjct: 191 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPF 221
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 108 bits (270), Expect = 2e-23
Identities = 83/254 (32%), Positives = 124/254 (48%), Gaps = 26/254 (10%)
Query: 21 LGTGGFGNVCLYQHRELDLKIAIKSCRLELST----KNRERWCHEIQIMKKLNHANVVKA 76
LG GGFG VC Q R A K RLE K +E QI++K+N VV
Sbjct: 192 LGKGGFGEVCACQVRATGKMYACK--RLEKKRIKKRKGESMALNEKQILEKVNSQFVVNL 249
Query: 77 CDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLH 136
E + L L + +GGDL+ + N G +E + L ++I G+ LH
Sbjct: 250 AYAYETKDALC-----LVLTIMNGGDLKFHIYNMGNP-GFEEERALFYAAEILCGLEDLH 303
Query: 137 ENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENK 196
++RDLKPENI+L D G +I DLG A + +G L VGT+ Y+APE+ N+
Sbjct: 304 RENTVYRDLKPENILLDDYGHI---RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ 360
Query: 197 PYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKD-PKCIFACEEMSGEVRFS 255
Y + DYW G +++E I G PF EK+K+++ + + EE+ +FS
Sbjct: 361 RYGLSPDYWGLGCLIYEMIEGQSPFRGR------KEKVKREEVDRRVLETEEVYSH-KFS 413
Query: 256 SHLPQPNSLCSLVV 269
+ S+C +++
Sbjct: 414 E---EAKSICKMLL 424
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 107 bits (268), Expect = 3e-23
Identities = 67/208 (32%), Positives = 103/208 (49%), Gaps = 10/208 (4%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV 74
++ R+ LGTG F V L + + +AIK E +EI ++ K+ H N+V
Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79
Query: 75 KACDVPEELNILIHDVPLLAMEYCSGGDL-RKLLNKPENCCGLKESQILSLLSDIGSGIR 133
D+ E L L M+ SGG+L +++ K E L+ + ++
Sbjct: 80 ALDDIYESGGHLY-----LIMQLVSGGELFDRIVEKGF----YTERDASRLIFQVLDAVK 130
Query: 134 YLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF 193
YLH+ I+HRDLKPEN++ + I D G +K D GS+ ++ GT Y+APE+
Sbjct: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
Query: 194 ENKPYTATVDYWSFGTMVFECIAGYRPF 221
KPY+ VD WS G + + + GY PF
Sbjct: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPF 218
>gi|14670383 death-associated kinase 2 [Homo sapiens]
Length = 370
Score = 107 bits (267), Expect = 4e-23
Identities = 70/214 (32%), Positives = 109/214 (50%), Gaps = 14/214 (6%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNR-----ERWCHEIQIMKKLN 69
+++ E LG+G F V + + L+ A K + S +R E E+ I++++
Sbjct: 23 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 82
Query: 70 HANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIG 129
H NV+ DV E ++ L +E SGG+L L + E+ L E + S + I
Sbjct: 83 HHNVITLHDVYENRTDVV-----LILELVSGGELFDFLAQKES---LSEEEATSFIKQIL 134
Query: 130 SGIRYLHENKIIHRDLKPENIVLQDVGGKIIH-KIIDLGYAKDVDQGSLCTSFVGTLQYL 188
G+ YLH KI H DLKPENI+L D I H K+ID G A +++ G + GT +++
Sbjct: 135 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFV 194
Query: 189 APELFENKPYTATVDYWSFGTMVFECIAGYRPFL 222
APE+ +P D WS G + + ++G PFL
Sbjct: 195 APEIVNYEPLGLEADMWSIGVITYILLSGASPFL 228
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 107 bits (267), Expect = 4e-23
Identities = 74/214 (34%), Positives = 110/214 (51%), Gaps = 17/214 (7%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH---EIQIMKKLNHA 71
+E E LG G +G V + L +AIKS R + K+ + H EI+IM LNH
Sbjct: 53 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKD-KIKDEQDLMHIRREIEIMSSLNHP 110
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
+++ +V E + ++ + MEY S GDL +++ + L E + I S
Sbjct: 111 HIIAIHEVFENSSKIV-----IVMEYASRGDLYDYISERQQ---LSEREARHFFRQIVSA 162
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
+ Y H+N+++HRDLK ENI+L D G I KI D G + QG +F G+ Y +PE
Sbjct: 163 VHYCHQNRVVHRDLKLENILL-DANGNI--KIADFGLSNLYHQGKFLQTFCGSPLYASPE 219
Query: 192 LFENKPYTA-TVDYWSFGTMVFECIAGYRPFLHH 224
+ KPYT VD WS G +++ + G PF H
Sbjct: 220 IVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGH 253
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 107 bits (267), Expect = 4e-23
Identities = 70/211 (33%), Positives = 108/211 (51%), Gaps = 13/211 (6%)
Query: 13 GPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSC-RLELSTKNRERWCHEIQIMKKLNHA 71
G + +R +G+G F V L H K+AIK + +L K + EI M+KL+H
Sbjct: 72 GFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHHP 131
Query: 72 NVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 131
N+++ +V E L+ L L MEY GG+L K L E + + S I S
Sbjct: 132 NIIRLYEVVETLSKLH-----LVMEYAGGGEL---FGKISTEGKLSEPESKLIFSQIVSA 183
Query: 132 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191
++++HEN+IIHRDLK EN+ K+ D G++ +G + +F G+ Y APE
Sbjct: 184 VKHMHENQIIHRDLKAENVFYT---SNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPE 240
Query: 192 LFENKPYTAT-VDYWSFGTMVFECIAGYRPF 221
LF ++ Y VD W+ G +++ + G PF
Sbjct: 241 LFRDEHYIGIYVDIWALGVLLYFMVTGTMPF 271
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 107 bits (266), Expect = 5e-23
Identities = 70/214 (32%), Positives = 110/214 (51%), Gaps = 11/214 (5%)
Query: 15 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWC-HEIQIMKKLNHANV 73
+E+RERLG+G F V L Q R +A+K C + + + +E +EI ++++++H N+
Sbjct: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALK-CIPKKALRGKEALVENEIAVLRRISHPNI 90
Query: 74 VKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIR 133
V DV E + L LAME +GG+L + + + E L+ + +
Sbjct: 91 VALEDVHESPSHLY-----LAMELVTGGELFDRIMERGS---YTEKDASHLVGQVLGAVS 142
Query: 134 YLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF 193
YLH I+HRDLKPEN++ + D G +K + G++ + GT Y+APEL
Sbjct: 143 YLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELL 201
Query: 194 ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQP 227
E KPY VD W+ G + + + GY PF P
Sbjct: 202 EQKPYGKAVDVWALGVISYILLCGYPPFYDESDP 235
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,182,363
Number of Sequences: 37866
Number of extensions: 1318086
Number of successful extensions: 5416
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 638
Number of HSP's successfully gapped in prelim test: 188
Number of HSP's that attempted gapping in prelim test: 3336
Number of HSP's gapped (non-prelim): 1011
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.