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Search of human proteins with 62198232
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62198232 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens]
(325 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62198232 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens] 635 0.0
gi|109150422 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-l... 447 e-126
gi|109150427 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-l... 447 e-126
gi|106049528 pyruvate carboxylase precursor [Homo sapiens] 39 0.005
gi|106049295 pyruvate carboxylase precursor [Homo sapiens] 39 0.005
gi|106049292 pyruvate carboxylase precursor [Homo sapiens] 39 0.005
gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [H... 29 6.5
gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform ... 29 6.5
gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform ... 29 6.5
gi|38202209 methyl-CpG binding domain protein 5 [Homo sapiens] 29 6.5
>gi|62198232 3-hydroxy-3-methylglutaryl CoA lyase [Homo sapiens]
Length = 325
Score = 635 bits (1639), Expect = 0.0
Identities = 325/325 (100%), Positives = 325/325 (100%)
Query: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
Sbjct: 1 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI 60
Query: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
Sbjct: 61 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG 120
Query: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
Sbjct: 121 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI 180
Query: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
Sbjct: 181 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ 240
Query: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
Sbjct: 241 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL 300
Query: 301 EAGNFICQALNRKTSSKVAQATCKL 325
EAGNFICQALNRKTSSKVAQATCKL
Sbjct: 301 EAGNFICQALNRKTSSKVAQATCKL 325
>gi|109150422 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like
1 isoform b [Homo sapiens]
Length = 340
Score = 447 bits (1151), Expect = e-126
Identities = 215/303 (70%), Positives = 259/303 (85%)
Query: 20 AVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSP 79
A TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVIE TSFVS
Sbjct: 35 AQETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSS 94
Query: 80 KWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNI 139
+WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAASE F+KKNI
Sbjct: 95 RWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNI 154
Query: 140 NCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYE 199
NCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+ Y MGCYE
Sbjct: 155 NCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYE 214
Query: 200 ISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSS 259
ISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQMG++VVDS+
Sbjct: 215 ISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSA 274
Query: 260 VAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVA 319
V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N+ T+SKVA
Sbjct: 275 VSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVA 334
Query: 320 QAT 322
QA+
Sbjct: 335 QAS 337
>gi|109150427 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like
1 isoform a [Homo sapiens]
Length = 370
Score = 447 bits (1150), Expect = e-126
Identities = 216/311 (69%), Positives = 261/311 (83%)
Query: 12 LVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVI 71
L G + TS + LP+ VKIVEVGPRDGLQNEK IV T +KI+ I+ LS+ GLSVI
Sbjct: 57 LAGTVACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVI 116
Query: 72 ETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAGAKEVVIFGAAS 131
E TSFVS +WVPQM DHTEV+KGI ++PG+ YPVLTPNL+GF AVAAGA E+ +FGAAS
Sbjct: 117 EVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAAS 176
Query: 132 ELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKK 191
E F+KKNINCSIEES +F+ ++K+A+ NI RGYVSCALGCPYEG I+P KV EV+K+
Sbjct: 177 ESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKR 236
Query: 192 FYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQM 251
Y MGCYEISLGDTIGVGTPG MK ML +VM+E+P ALAVHCHDTYGQALAN L ALQM
Sbjct: 237 LYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQM 296
Query: 252 GVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALN 311
G++VVDS+V+GLGGCPYA+GASGN+ATEDL+YML GLG++TGVNL K++EAG+FIC+A+N
Sbjct: 297 GINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVN 356
Query: 312 RKTSSKVAQAT 322
+ T+SKVAQA+
Sbjct: 357 KTTNSKVAQAS 367
>gi|106049528 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 39.3 bits (90), Expect = 0.005
Identities = 36/154 (23%), Positives = 64/154 (41%), Gaps = 8/154 (5%)
Query: 154 LKAAQSANISVRGYVSCA--LGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTP 211
++AA SA V +S + P K S + ++ G + + + D G+ P
Sbjct: 690 MEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKP 749
Query: 212 GIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQG 271
++S++ P L +H HDT G +A L Q G VVD + + G +Q
Sbjct: 750 TACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMT-SQP 808
Query: 272 ASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNF 305
+ G LV G + T V ++++ + +
Sbjct: 809 SMG-----ALVACTRGTPLDTEVPMERVFDYSEY 837
>gi|106049295 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 39.3 bits (90), Expect = 0.005
Identities = 36/154 (23%), Positives = 64/154 (41%), Gaps = 8/154 (5%)
Query: 154 LKAAQSANISVRGYVSCA--LGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTP 211
++AA SA V +S + P K S + ++ G + + + D G+ P
Sbjct: 690 MEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKP 749
Query: 212 GIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQG 271
++S++ P L +H HDT G +A L Q G VVD + + G +Q
Sbjct: 750 TACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMT-SQP 808
Query: 272 ASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNF 305
+ G LV G + T V ++++ + +
Sbjct: 809 SMG-----ALVACTRGTPLDTEVPMERVFDYSEY 837
>gi|106049292 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 39.3 bits (90), Expect = 0.005
Identities = 36/154 (23%), Positives = 64/154 (41%), Gaps = 8/154 (5%)
Query: 154 LKAAQSANISVRGYVSCA--LGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTP 211
++AA SA V +S + P K S + ++ G + + + D G+ P
Sbjct: 690 MEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKP 749
Query: 212 GIMKDMLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQG 271
++S++ P L +H HDT G +A L Q G VVD + + G +Q
Sbjct: 750 TACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMT-SQP 808
Query: 272 ASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNF 305
+ G LV G + T V ++++ + +
Sbjct: 809 SMG-----ALVACTRGTPLDTEVPMERVFDYSEY 837
>gi|223555935 dynein, axonemal, heavy polypeptide 14 isoform 1 [Homo
sapiens]
Length = 4515
Score = 28.9 bits (63), Expect = 6.5
Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 30 PKRV-KIVEVGPRDGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPK 80
PK V + + + L+NEKN++ +K IDML+++ V+ + F K
Sbjct: 3567 PKEVHEFISISKEPNLENEKNLLDKHIK-SAIDMLTKSIFKVVSSALFNEDK 3617
>gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform b
[Homo sapiens]
Length = 954
Score = 28.9 bits (63), Expect = 6.5
Identities = 46/188 (24%), Positives = 69/188 (36%), Gaps = 12/188 (6%)
Query: 138 NINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGC 197
N++ S+E QR D +L+ + CA C + SP E + +S
Sbjct: 533 NVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPP-EESSPGEWSEAL 591
Query: 198 YEI--SLGDTIGVGTPGIMKDMLSAVMQE-VPLAALAVHCHDTYGQALANTLMALQMGVS 254
Y + +L D + + + K M+ +MQ+ P A + TL AL G
Sbjct: 592 YPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGF- 650
Query: 255 VVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKT 314
+ L C + G L T L+ E L G L L + I R
Sbjct: 651 -----IIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDL--RNV 703
Query: 315 SSKVAQAT 322
+ KV QAT
Sbjct: 704 TFKVTQAT 711
>gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform a
[Homo sapiens]
Length = 938
Score = 28.9 bits (63), Expect = 6.5
Identities = 46/188 (24%), Positives = 69/188 (36%), Gaps = 12/188 (6%)
Query: 138 NINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGC 197
N++ S+E QR D +L+ + CA C + SP E + +S
Sbjct: 533 NVDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPP-EESSPGEWSEAL 591
Query: 198 YEI--SLGDTIGVGTPGIMKDMLSAVMQE-VPLAALAVHCHDTYGQALANTLMALQMGVS 254
Y + +L D + + + K M+ +MQ+ P A + TL AL G
Sbjct: 592 YPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGF- 650
Query: 255 VVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLLEAGNFICQALNRKT 314
+ L C + G L T L+ E L G L L + I R
Sbjct: 651 -----IIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDL--RNV 703
Query: 315 SSKVAQAT 322
+ KV QAT
Sbjct: 704 TFKVTQAT 711
>gi|38202209 methyl-CpG binding domain protein 5 [Homo sapiens]
Length = 1494
Score = 28.9 bits (63), Expect = 6.5
Identities = 22/61 (36%), Positives = 30/61 (49%), Gaps = 7/61 (11%)
Query: 217 MLSAVMQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNL 276
M S+V+Q +PL AVHCH+ ANT + V + +AGL A G G L
Sbjct: 744 MNSSVLQNIPLRGEAVHCHN------ANTNF-VHSNSPVPNHHLAGLINQIQASGNCGML 796
Query: 277 A 277
+
Sbjct: 797 S 797
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,253,773
Number of Sequences: 37866
Number of extensions: 399266
Number of successful extensions: 995
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 987
Number of HSP's gapped (non-prelim): 12
length of query: 325
length of database: 18,247,518
effective HSP length: 102
effective length of query: 223
effective length of database: 14,385,186
effective search space: 3207896478
effective search space used: 3207896478
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.