BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] (628 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 1275 0.0 gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 638 0.0 gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 268 1e-71 gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 256 3e-68 gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 256 3e-68 gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 256 3e-68 gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 256 3e-68 gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 253 4e-67 gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 253 4e-67 gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 253 4e-67 gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 253 4e-67 gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 253 4e-67 gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 249 4e-66 gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 244 2e-64 gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 241 1e-63 gi|116256471 SNF1-like kinase [Homo sapiens] 239 7e-63 gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 236 4e-62 gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 236 6e-62 gi|38569460 SNF1-like kinase 2 [Homo sapiens] 234 2e-61 gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 221 2e-57 gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 218 1e-56 gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 197 3e-50 gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 195 9e-50 gi|156105707 SNF related kinase [Homo sapiens] 186 4e-47 gi|156105705 SNF related kinase [Homo sapiens] 186 4e-47 gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 173 5e-43 gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 173 5e-43 gi|89363047 death-associated protein kinase 1 [Homo sapiens] 172 8e-43 gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 172 1e-42 gi|4557511 death-associated protein kinase 3 [Homo sapiens] 172 1e-42 >gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] Length = 628 Score = 1275 bits (3300), Expect = 0.0 Identities = 628/628 (100%), Positives = 628/628 (100%) Query: 1 MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLG 60 MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLG Sbjct: 1 MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLG 60 Query: 61 KGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE 120 KGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE Sbjct: 61 KGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFE 120 Query: 121 NSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLEN 180 NSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLEN Sbjct: 121 NSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLEN 180 Query: 181 ILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLL 240 ILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLL Sbjct: 181 ILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLL 240 Query: 241 YILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASH 300 YILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASH Sbjct: 241 YILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASH 300 Query: 301 WWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPG 360 WWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPG Sbjct: 301 WWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPG 360 Query: 361 GGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAE 420 GGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAE Sbjct: 361 GGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAE 420 Query: 421 GVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVS 480 GVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVS Sbjct: 421 GVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVS 480 Query: 481 GDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPS 540 GDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPS Sbjct: 481 GDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPS 540 Query: 541 GAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPL 600 GAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPL Sbjct: 541 GAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPL 600 Query: 601 GDSCFSLTDCQEVTATYRQALRVCSKLT 628 GDSCFSLTDCQEVTATYRQALRVCSKLT Sbjct: 601 GDSCFSLTDCQEVTATYRQALRVCSKLT 628 >gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] Length = 661 Score = 638 bits (1646), Expect = 0.0 Identities = 369/641 (57%), Positives = 433/641 (67%), Gaps = 67/641 (10%) Query: 36 KKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDL 94 K VKRHHHKHNL+HRYE ETLGKGTYGKVK+A E SGR+VAIKSIRKDKIKDEQD+ Sbjct: 38 KPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDM 97 Query: 95 MHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARH 154 +HIRREIEIMSSLNHPHII+I+EVFEN KIVI+MEYAS+G+LYDYISER++LSERE RH Sbjct: 98 VHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRH 157 Query: 155 FFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPL 214 FFRQIVSAVHYCH+N VVHRDLKLENILLD N NIKIADFGLSNLY + KFLQTFCGSPL Sbjct: 158 FFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPL 217 Query: 215 YASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPS 274 YASPEIVNG+PY GPEVDSW+LGVLLY LV+GTMPFDG DHK L++QIS+G YREP +PS Sbjct: 218 YASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS 277 Query: 275 DACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMAD 334 DA GLIRW+LMVNP RRAT+ED+A+HWWVNWGY + V + +A H+ P A + D Sbjct: 278 DARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESP----LLARIID 333 Query: 335 WLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADD 394 W RS+ + AK+ K ++ LERQ SLKKS+KEND AQS D Sbjct: 334 WHHRSTGLQADTEAKMKGLAKP-----TTSEVMLERQRSLKKSKKENDFAQS----GQDA 384 Query: 395 TAHRPGKSNLKLPKGILKKKVSAS--------AEGV----------------------QE 424 P K + K PKGILKK+ ++ EGV Sbjct: 385 VPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPS 444 Query: 425 DPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPK 484 P P SP Q+A +PKKGILKK +QRESGYYSSPE SES ELLD+ DV S P Sbjct: 445 SPEAEVPGKLSPKQSA-TMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPS 503 Query: 485 EQKPPQA----SGLLLHRKGILKLNGKFSQTALE--LAAP--TTFGSLDEL-APPRPLAR 535 P A L RKGILK + K+S ++ L +P T SL E P L+R Sbjct: 504 PSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSR 563 Query: 536 A-SRPSGAVSEDSILSSESFDQLDLPERLP-EPPLRGCVSVDN------LTGLEEPPSEG 587 + SRPS +S+DS+LSS+SFD LDL E P +R CVS +N GL+ P Sbjct: 564 SYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRP- 622 Query: 588 PGSCLRRWRQDPLGDSCFS-LTDCQEVTATYRQALRVCSKL 627 L+R+R + L DS FS LTD +VT Y+QAL +CSKL Sbjct: 623 --QYLKRYR-NRLADSSFSLLTDMDDVTQVYKQALEICSKL 660 >gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo sapiens] Length = 688 Score = 268 bits (685), Expect = 1e-71 Identities = 138/268 (51%), Positives = 179/268 (66%), Gaps = 6/268 (2%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L T+GKG + KVK AR +GR VAIK I K ++ + L + RE+ IM LNHP+ Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPSSLQKLFREVRIMKGLNHPN 117 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAVHYCHQ + Sbjct: 118 IVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNI 177 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 178 VHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEV 237 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDGH+ K L +++ G YR P S C ++R L++NP + Sbjct: 238 DIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAK 297 Query: 291 RATLEDVASHWWVNWGYATRVGEQEAPH 318 R TLE + W+N GY GE+ P+ Sbjct: 298 RCTLEQIMKDKWINIGYE---GEELKPY 322 >gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d [Homo sapiens] Length = 713 Score = 256 bits (655), Expect = 3e-68 Identities = 132/257 (51%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +GR VAIK I K ++ + L + RE+ IM LNHP+ Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 114 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + ++MEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ R+ Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV 234 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP + Sbjct: 235 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIK 294 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 295 RGTLEQIMKDRWINAGH 311 >gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b [Homo sapiens] Length = 744 Score = 256 bits (655), Expect = 3e-68 Identities = 132/257 (51%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +GR VAIK I K ++ + L + RE+ IM LNHP+ Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 114 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + ++MEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ R+ Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV 234 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP + Sbjct: 235 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIK 294 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 295 RGTLEQIMKDRWINAGH 311 >gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a [Homo sapiens] Length = 753 Score = 256 bits (655), Expect = 3e-68 Identities = 132/257 (51%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +GR VAIK I K ++ + L + RE+ IM LNHP+ Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 114 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + ++MEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ R+ Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV 234 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP + Sbjct: 235 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIK 294 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 295 RGTLEQIMKDRWINAGH 311 >gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c [Homo sapiens] Length = 729 Score = 256 bits (655), Expect = 3e-68 Identities = 132/257 (51%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +GR VAIK I K ++ + L + RE+ IM LNHP+ Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 114 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + ++MEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ R+ Sbjct: 115 IVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRI 174 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 175 VHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEV 234 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP + Sbjct: 235 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIK 294 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 295 RGTLEQIMKDRWINAGH 311 >gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f [Homo sapiens] Length = 709 Score = 253 bits (646), Expect = 4e-67 Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +G+ VA+K I K ++ + L + RE+ IM LNHP+ Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ + Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP++ Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 292 RGTLEQIMKDRWMNVGH 308 >gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e [Homo sapiens] Length = 719 Score = 253 bits (646), Expect = 4e-67 Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +G+ VA+K I K ++ + L + RE+ IM LNHP+ Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ + Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP++ Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 292 RGTLEQIMKDRWMNVGH 308 >gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d [Homo sapiens] Length = 788 Score = 253 bits (646), Expect = 4e-67 Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +G+ VA+K I K ++ + L + RE+ IM LNHP+ Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ + Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP++ Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 292 RGTLEQIMKDRWMNVGH 308 >gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c [Homo sapiens] Length = 724 Score = 253 bits (646), Expect = 4e-67 Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +G+ VA+K I K ++ + L + RE+ IM LNHP+ Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 111 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ + Sbjct: 112 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 171 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 172 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 231 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP++ Sbjct: 232 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 292 RGTLEQIMKDRWMNVGH 308 >gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens] Length = 745 Score = 253 bits (646), Expect = 4e-67 Identities = 130/257 (50%), Positives = 175/257 (68%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y L+T+GKG + KVK AR +G+ VA+K I K ++ + L + RE+ IM LNHP+ Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPN 78 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ + Sbjct: 79 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFI 138 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDA+ NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 139 VHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEV 198 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ L++NP++ Sbjct: 199 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 258 Query: 291 RATLEDVASHWWVNWGY 307 R TLE + W+N G+ Sbjct: 259 RGTLEQIMKDRWMNVGH 275 >gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo sapiens] Length = 795 Score = 249 bits (637), Expect = 4e-66 Identities = 129/257 (50%), Positives = 173/257 (67%), Gaps = 3/257 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y +T+GKG + KVK AR +GR VA+K I K ++ + L + RE+ IM LNHP+ Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 118 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I+ + EV E + +VMEYAS G+++DY+ ++ E+EAR FRQIVSAV YCHQ + Sbjct: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 178 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLD + NIKIADFG SN + G L TFCGSP YA+PE+ GK Y GPEV Sbjct: 179 VHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEV 238 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY LV G++PFDG + K L +++ G YR P S C L++ LL++NP + Sbjct: 239 DVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIK 298 Query: 291 RATLEDVASHWWVNWGY 307 R +LE + W+N G+ Sbjct: 299 RGSLEQIMKDRWMNVGH 315 >gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 1 [Homo sapiens] Length = 559 Score = 244 bits (623), Expect = 2e-64 Identities = 125/265 (47%), Positives = 178/265 (67%), Gaps = 5/265 (1%) Query: 41 KRHHHKHNLRHRYEFLETLGKGTYGKVKKAR-ESSGRLVAIKSIRKDKIKDEQDLMHIRR 99 ++H + + H Y +TLG GT+GKVK + E +G VA+K + + KI+ + IRR Sbjct: 16 QKHDGRVKIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74 Query: 100 EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQI 159 EI+ + HPHII +++V S I +VMEY S G+L+DYI + +L E+E+R F+QI Sbjct: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQI 134 Query: 160 VSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPE 219 +S V YCH++ VVHRDLK EN+LLDA+ N KIADFGLSN+ G+FL+T CGSP YA+PE Sbjct: 135 LSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 194 Query: 220 IVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPP--KPSDAC 277 +++G+ Y GPEVD WS GV+LY L+ GT+PFD L K+I +G + P PS Sbjct: 195 VISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS-VI 253 Query: 278 GLIRWLLMVNPTRRATLEDVASHWW 302 L++ +L V+P +RAT++D+ H W Sbjct: 254 SLLKHMLQVDPMKRATIKDIREHEW 278 >gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] Length = 1263 Score = 241 bits (616), Expect = 1e-63 Identities = 124/258 (48%), Positives = 177/258 (68%), Gaps = 3/258 (1%) Query: 53 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 YE T+GKG + VK+A + VAIK I K ++ DE++L I RE++IM L HPH Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQL-DEENLKKIFREVQIMKMLCHPH 66 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 II +++V E I +V EYAS G+++D++ +++E+EAR F+QIV+AV++CH + Sbjct: 67 IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLDAN NIKIADFG SNL+ G+ L+T+CGSP YA+PE+ GK Y GP+V Sbjct: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 186 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY+LV G +PFDG + L ++ +G +R P S C LIR +L+++P + Sbjct: 187 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 246 Query: 291 RATLEDVASHWWVNWGYA 308 R ++E + H W+ G A Sbjct: 247 RLSMEQICKHKWMKLGDA 264 >gi|116256471 SNF1-like kinase [Homo sapiens] Length = 783 Score = 239 bits (609), Expect = 7e-63 Identities = 121/253 (47%), Positives = 167/253 (66%), Gaps = 3/253 (1%) Query: 53 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y+ TLGKG + VK AR + VAIK I K ++ D +L I RE+++M LNHPH Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPH 85 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 II +++V E + IV E+A G+++DY++ LSE EAR F QI+SAV YCH + + Sbjct: 86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHI 145 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLD N +IK+ADFG N Y G+ L T+CGSP YA+PE+ GK Y GP++ Sbjct: 146 VHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQL 205 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WSLGV+LY+LV G++PFDG + L +++ G +R P S C LIR +L+V+P R Sbjct: 206 DIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPAR 265 Query: 291 RATLEDVASHWWV 303 R T+ + H W+ Sbjct: 266 RITIAQIRQHRWM 278 >gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens] Length = 552 Score = 236 bits (603), Expect = 4e-62 Identities = 120/264 (45%), Positives = 173/264 (65%), Gaps = 3/264 (1%) Query: 41 KRHHHKHNLRHRYEFLETLGKGTYGKVK-KARESSGRLVAIKSIRKDKIKDEQDLMHIRR 99 ++H + + H Y +TLG GT+GKVK + +G VA+K + + KI+ + I+R Sbjct: 5 QKHDGRVKIGH-YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKR 63 Query: 100 EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQI 159 EI+ + HPHII +++V + +VMEY S G+L+DYI + ++ E EAR F+QI Sbjct: 64 EIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQI 123 Query: 160 VSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPE 219 +SAV YCH++ VVHRDLK EN+LLDA+ N KIADFGLSN+ G+FL+T CGSP YA+PE Sbjct: 124 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPE 183 Query: 220 IVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPS-DACG 278 +++G+ Y GPEVD WS GV+LY L+ GT+PFD L K+I G + P + Sbjct: 184 VISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 Query: 279 LIRWLLMVNPTRRATLEDVASHWW 302 L+ +L V+P +RAT++D+ H W Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEW 267 >gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 2 [Homo sapiens] Length = 574 Score = 236 bits (601), Expect = 6e-62 Identities = 125/280 (44%), Positives = 179/280 (63%), Gaps = 20/280 (7%) Query: 41 KRHHHKHNLRHRYEFLETLGKGTYGKVKKAR-ESSGRLVAIKSIRKDKIKDEQDLMHIRR 99 ++H + + H Y +TLG GT+GKVK + E +G VA+K + + KI+ + IRR Sbjct: 16 QKHDGRVKIGH-YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRR 74 Query: 100 EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISER--------------- 144 EI+ + HPHII +++V S I +VMEY S G+L+DYI + Sbjct: 75 EIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGST 134 Query: 145 QQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGK 204 ++L E+E+R F+QI+S V YCH++ VVHRDLK EN+LLDA+ N KIADFGLSN+ G+ Sbjct: 135 KELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE 194 Query: 205 FLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISN 264 FL+T CGSP YA+PE+++G+ Y GPEVD WS GV+LY L+ GT+PFD L K+I + Sbjct: 195 FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICD 254 Query: 265 GAYREPP--KPSDACGLIRWLLMVNPTRRATLEDVASHWW 302 G + P PS L++ +L V+P +RAT++D+ H W Sbjct: 255 GIFYTPQYLNPS-VISLLKHMLQVDPMKRATIKDIREHEW 293 >gi|38569460 SNF1-like kinase 2 [Homo sapiens] Length = 926 Score = 234 bits (596), Expect = 2e-61 Identities = 118/253 (46%), Positives = 169/253 (66%), Gaps = 3/253 (1%) Query: 53 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y+ TLGKG + VK R + VAIK I K ++ D +L I RE++IM L+HPH Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL-DAVNLEKIYREVQIMKMLDHPH 78 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 II +++V E S + +V EYA G+++DY++ +L+E EAR F QI+SAV YCH ++ Sbjct: 79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKI 138 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 VHRDLK EN+LLD N NIKIADFG N + G+ L T+CGSP YA+PE+ G+ Y GP++ Sbjct: 139 VHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQL 198 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D WS+GV+LY+LV G +PFDG IL +++ G +R P S+ C LIR +L+++P++ Sbjct: 199 DIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSK 258 Query: 291 RATLEDVASHWWV 303 R T+ + H W+ Sbjct: 259 RLTIAQIKEHKWM 271 >gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] Length = 778 Score = 221 bits (562), Expect = 2e-57 Identities = 110/267 (41%), Positives = 167/267 (62%), Gaps = 8/267 (2%) Query: 43 HHHKHNLRHR-----YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMH 96 H H H +H Y +TLGKG G VK +G+ VAIK + ++K+ E LM Sbjct: 19 HPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLS-ESVLMK 77 Query: 97 IRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFF 156 + REI I+ + HPH++ +H+V+EN + +V+E+ S G+L+DY+ ++ +L+ +EAR FF Sbjct: 78 VEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFF 137 Query: 157 RQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYA 216 RQIVSA+ +CH + HRDLK EN+LLD NI+IADFG+++L L+T CGSP YA Sbjct: 138 RQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYA 197 Query: 217 SPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPP-KPSD 275 PE++ G+ Y G D WS GV+L+ L+ G +PFD + + L++++ G + P P D Sbjct: 198 CPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPD 257 Query: 276 ACGLIRWLLMVNPTRRATLEDVASHWW 302 L+R ++ V P +R +LE + H W Sbjct: 258 CQSLLRGMIEVEPEKRLSLEQIQKHPW 284 >gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] Length = 668 Score = 218 bits (556), Expect = 1e-56 Identities = 142/450 (31%), Positives = 229/450 (50%), Gaps = 38/450 (8%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y +TLGKG G VK + + VAIK + ++K+ E LM + REI I+ + HPH Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLS-ESVLMKVEREIAILKLIEHPH 77 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 ++ +H+V+EN + +V+E+ S G+L+DY+ ++ +L+ +EAR FFRQI+SA+ +CH + + Sbjct: 78 VLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSI 137 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 HRDLK EN+LLD NI+IADFG+++L L+T CGSP YA PE++ G+ Y G + Sbjct: 138 CHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 197 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPP-KPSDACGLIRWLLMVNPTR 290 D WS GV+L+ L+ G +PFD + + L++++ G + P P D L+R ++ V+ R Sbjct: 198 DVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAAR 257 Query: 291 RATLEDVASHWWVNWGYATRVGEQEAPHE---GGHPGSDSARASMADWLR-----RSSRP 342 R TLE + H W G EQ P + P + + D + R Sbjct: 258 RLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNK 317 Query: 343 LL-------ENGAKVCSFF------------KQHAPGGGSTTPGLERQHS--LKKSRKEN 381 LL EN K+ F + P P +R S L + K Sbjct: 318 LLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRR 377 Query: 382 DMAQSLH-SDTADDTAHRPGKSNLKLPK-GILKKKVSASAEGVQEDP---PELSPIPASP 436 +S+ D + P + +++ + G + +S ++ G+ P P ++P P+ Sbjct: 378 PERKSMEVLSVTDGGSPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPR 437 Query: 437 GQAAPLLPKKGILKKPRQRESGYYSSPEPS 466 G P PK + P++ +G + PS Sbjct: 438 GSPLP-TPKGTPVHTPKESPAGTPNPTPPS 466 >gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] Length = 651 Score = 197 bits (500), Expect = 3e-50 Identities = 111/260 (42%), Positives = 156/260 (60%), Gaps = 8/260 (3%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 YE ET+G G + KVK A +G +VAIK + K+ + DL I+ EIE + +L H H Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS--DLPRIKTEIEALKNLRHQH 68 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 I ++ V E ++KI +V+EY G+L+DYI + +LSE E R FRQIVSAV Y H Sbjct: 69 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGY 128 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGK--FLQTFCGSPLYASPEIVNGKPYTGP 229 HRDLK EN+L D +K+ DFGL K LQT CGS YA+PE++ GK Y G Sbjct: 129 AHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGS 188 Query: 230 EVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPP--KPSDACGLIRWLLMVN 287 E D WS+G+LLY+L+ G +PFD + L K+I G Y P PS L++ +L V+ Sbjct: 189 EADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSIL-LLQQMLQVD 247 Query: 288 PTRRATLEDVASHWWVNWGY 307 P +R +++++ +H W+ Y Sbjct: 248 PKKRISMKNLLNHPWIMQDY 267 >gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] Length = 436 Score = 195 bits (496), Expect = 9e-50 Identities = 108/253 (42%), Positives = 152/253 (60%), Gaps = 3/253 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y +G G + +VK S + VAIK + K K+ D++ + REI M L+HP+ Sbjct: 74 YRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKL-DQKTQRLLSREISSMEKLHHPN 132 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171 II ++EV E SK+ +VMEYA G+L+ IS +LSE E++ F QIVSAV + H+N++ Sbjct: 133 IIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQI 192 Query: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231 +HRDLK EN+ +N +K+ DFG S + +G+ L TFCGSP YA+PE+ + Y G V Sbjct: 193 IHRDLKAENVFYTSNTCVKVGDFGFSTVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYV 252 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290 D W+LGVLLY +V GTMPF L K I G Y PP S+ C LIR +L PT Sbjct: 253 DIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPTE 312 Query: 291 RATLEDVASHWWV 303 R ++ + + W+ Sbjct: 313 RYGIDCIMNDEWM 325 >gi|156105707 SNF related kinase [Homo sapiens] Length = 765 Score = 186 bits (473), Expect = 4e-47 Identities = 102/255 (40%), Positives = 155/255 (60%), Gaps = 5/255 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y+ +TLG+G + VK AR +G VA+K I K K+ D H+ +E+ M + HP+ Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 74 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQ-LSEREARHFFRQIVSAVHYCHQNR 170 I+ ++EV + +K+ +++E GD++DYI + ++ L+E A+ +F QIV A+ YCH+ Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134 Query: 171 VVHRDLKLENILL-DANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGP 229 VVHRDLK EN++ + G +K+ DFG SN + GK L T CGS Y++PEI+ G Y P Sbjct: 135 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194 Query: 230 EVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNP 288 VD WSLGV+L++LV G PF + + I + Y P S C LI +L +P Sbjct: 195 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDP 254 Query: 289 TRRATLEDVASHWWV 303 RRA+LE++ +H W+ Sbjct: 255 KRRASLEEIENHPWL 269 >gi|156105705 SNF related kinase [Homo sapiens] Length = 765 Score = 186 bits (473), Expect = 4e-47 Identities = 102/255 (40%), Positives = 155/255 (60%), Gaps = 5/255 (1%) Query: 53 YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111 Y+ +TLG+G + VK AR +G VA+K I K K+ D H+ +E+ M + HP+ Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKL-DTLATGHLFQEVRCMKLVQHPN 74 Query: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQ-LSEREARHFFRQIVSAVHYCHQNR 170 I+ ++EV + +K+ +++E GD++DYI + ++ L+E A+ +F QIV A+ YCH+ Sbjct: 75 IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLH 134 Query: 171 VVHRDLKLENILL-DANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGP 229 VVHRDLK EN++ + G +K+ DFG SN + GK L T CGS Y++PEI+ G Y P Sbjct: 135 VVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAP 194 Query: 230 EVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNP 288 VD WSLGV+L++LV G PF + + I + Y P S C LI +L +P Sbjct: 195 AVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDP 254 Query: 289 TRRATLEDVASHWWV 303 RRA+LE++ +H W+ Sbjct: 255 KRRASLEEIENHPWL 269 >gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] Length = 479 Score = 173 bits (438), Expect = 5e-43 Identities = 92/251 (36%), Positives = 150/251 (59%), Gaps = 4/251 (1%) Query: 44 HHKHNLRHRYEFLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKIKDEQDLMHIRREIE 102 HHK + +++L+ LGKGT+GKV RE +SG+ A+K ++K+ I + ++ H E Sbjct: 139 HHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESR 198 Query: 103 IMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSA 162 ++ + HP + ++ F+ ++ VMEY + G+L+ ++S + SE R + +IVSA Sbjct: 199 VLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSA 258 Query: 163 VHYCHQNRVVHRDLKLENILLDANGNIKIADFGL-SNLYHQGKFLQTFCGSPLYASPEIV 221 + Y H ++V+RDLKLEN++LD +G+IKI DFGL ++TFCG+P Y +PE++ Sbjct: 259 LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL 318 Query: 222 NGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREP-PKPSDACGLI 280 Y G VD W LGV++Y ++ G +PF DH+ L + I + P SDA L+ Sbjct: 319 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLL 377 Query: 281 RWLLMVNPTRR 291 LL+ +P +R Sbjct: 378 SGLLIKDPNKR 388 >gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] Length = 465 Score = 173 bits (438), Expect = 5e-43 Identities = 92/251 (36%), Positives = 150/251 (59%), Gaps = 4/251 (1%) Query: 44 HHKHNLRHRYEFLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKIKDEQDLMHIRREIE 102 HHK + +++L+ LGKGT+GKV RE +SG+ A+K ++K+ I + ++ H E Sbjct: 139 HHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESR 198 Query: 103 IMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSA 162 ++ + HP + ++ F+ ++ VMEY + G+L+ ++S + SE R + +IVSA Sbjct: 199 VLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSA 258 Query: 163 VHYCHQNRVVHRDLKLENILLDANGNIKIADFGL-SNLYHQGKFLQTFCGSPLYASPEIV 221 + Y H ++V+RDLKLEN++LD +G+IKI DFGL ++TFCG+P Y +PE++ Sbjct: 259 LDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVL 318 Query: 222 NGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREP-PKPSDACGLI 280 Y G VD W LGV++Y ++ G +PF DH+ L + I + P SDA L+ Sbjct: 319 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLL 377 Query: 281 RWLLMVNPTRR 291 LL+ +P +R Sbjct: 378 SGLLIKDPNKR 388 >gi|89363047 death-associated protein kinase 1 [Homo sapiens] Length = 1430 Score = 172 bits (436), Expect = 8e-43 Identities = 101/271 (37%), Positives = 157/271 (57%), Gaps = 14/271 (5%) Query: 46 KHNLRHRYEFLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKIKDEQ---DLMHIRREI 101 + N+ Y+ E LG G + VKK RE S+G A K I+K + K + I RE+ Sbjct: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65 Query: 102 EIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVS 161 I+ + HP++I +HEV+EN + +++++E + G+L+D+++E++ L+E EA F +QI++ Sbjct: 66 SILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILN 125 Query: 162 AVHYCHQNRVVHRDLKLENI-LLDAN---GNIKIADFGLSNLYHQGKFLQTFCGSPLYAS 217 V+Y H ++ H DLK ENI LLD N IKI DFGL++ G + G+P + + Sbjct: 126 GVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVA 185 Query: 218 PEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYR-EPPKPSDA 276 PEIVN +P G E D WS+GV+ YIL+ G PF G + + +S Y E S+ Sbjct: 186 PEIVNYEP-LGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNT 244 Query: 277 CGL----IRWLLMVNPTRRATLEDVASHWWV 303 L IR LL+ +P +R T++D H W+ Sbjct: 245 SALAKDFIRRLLVKDPKKRMTIQDSLQHPWI 275 >gi|14042947 testis-specific serine kinase 1 [Homo sapiens] Length = 367 Score = 172 bits (435), Expect = 1e-42 Identities = 106/255 (41%), Positives = 147/255 (57%), Gaps = 10/255 (3%) Query: 59 LGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHE 117 LG+G+Y KVK A + VAIK I + K + + REIEI++ LNH II +E Sbjct: 18 LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYE 77 Query: 118 VFENS-SKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDL 176 +FE S K+ IVME A +GDL + I R L E EAR F Q+ A+ YCH VVHRDL Sbjct: 78 IFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDL 137 Query: 177 KLENILLDANGNIKIADFGLSNLY---HQGKFL--QTFCGSPLYASPEIVNGKPYTGPEV 231 K +N+LLD + NIK++DF S G+ +TFCGSP YA+PE++ G PY Sbjct: 138 KCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVY 197 Query: 232 DSWSLGVLLYILVHGTMPFDGHDHKILV---KQISNGAYREPPKPSDACGLIRWLLMVNP 288 D WSLGV+LYI+V G+MP+D + K ++ K+ R + LI +L + Sbjct: 198 DIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDV 257 Query: 289 TRRATLEDVASHWWV 303 RR ++++ SH W+ Sbjct: 258 NRRLHIDEILSHCWM 272 >gi|4557511 death-associated protein kinase 3 [Homo sapiens] Length = 454 Score = 172 bits (435), Expect = 1e-42 Identities = 96/271 (35%), Positives = 151/271 (55%), Gaps = 14/271 (5%) Query: 46 KHNLRHRYEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIKDEQ---DLMHIRREI 101 + ++ YE E LG G + V+K R+ +G+ A K I+K ++ + I RE+ Sbjct: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65 Query: 102 EIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVS 161 I+ + HP+II +H++FEN + +V+++E S G+L+D+++E++ L+E EA F +QI+ Sbjct: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILD 125 Query: 162 AVHYCHQNRVVHRDLKLENILL----DANGNIKIADFGLSNLYHQGKFLQTFCGSPLYAS 217 VHY H R+ H DLK ENI+L N IK+ DFG+++ G + G+P + + Sbjct: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 Query: 218 PEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPK----- 272 PEIVN +P G E D WS+GV+ YIL+ G PF G + + IS Y + Sbjct: 186 PEIVNYEP-LGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNT 244 Query: 273 PSDACGLIRWLLMVNPTRRATLEDVASHWWV 303 A IR LL+ +P RR T+ H W+ Sbjct: 245 SELAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.133 0.398 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,527,812 Number of Sequences: 37866 Number of extensions: 1529630 Number of successful extensions: 8290 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 735 Number of HSP's successfully gapped in prelim test: 200 Number of HSP's that attempted gapping in prelim test: 5497 Number of HSP's gapped (non-prelim): 1410 length of query: 628 length of database: 18,247,518 effective HSP length: 108 effective length of query: 520 effective length of database: 14,157,990 effective search space: 7362154800 effective search space used: 7362154800 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.