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Search of human proteins with 13562088
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13562088 leucine-rich repeat-containing 3 precursor [Homo
sapiens]
(257 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13562088 leucine-rich repeat-containing 3 precursor [Homo sap... 526 e-150
gi|16418445 leucine rich repeat containing 3B [Homo sapiens] 233 9e-62
gi|239756808 PREDICTED: similar to hCG2044133 [Homo sapiens] 168 4e-42
gi|239751294 PREDICTED: similar to hCG2044133 [Homo sapiens] 168 4e-42
gi|239745789 PREDICTED: hypothetical protein LOC728129 [Homo sap... 168 4e-42
gi|194306623 immunoglobulin superfamily containing leucine-rich ... 84 2e-16
gi|194306621 immunoglobulin superfamily containing leucine-rich ... 84 2e-16
gi|39930401 immunoglobulin superfamily containing leucine-rich r... 84 2e-16
gi|194306618 immunoglobulin superfamily containing leucine-rich ... 84 2e-16
gi|41582239 immunoglobulin superfamily containing leucine-rich r... 84 2e-16
gi|5031809 immunoglobulin superfamily containing leucine-rich re... 84 2e-16
gi|194440719 chondroadherin-like [Homo sapiens] 72 6e-13
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 72 6e-13
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 71 8e-13
gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens] 70 1e-12
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 68 9e-12
gi|4759146 slit homolog 2 [Homo sapiens] 67 1e-11
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 67 1e-11
gi|51317373 netrin-G1 ligand [Homo sapiens] 67 1e-11
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 67 2e-11
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 67 2e-11
gi|52353306 leucine rich repeat containing 55 [Homo sapiens] 67 2e-11
gi|27363458 leucine rich repeat and fibronectin type III domain ... 67 2e-11
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 66 3e-11
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 66 3e-11
gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 65 4e-11
gi|11321571 slit homolog 3 [Homo sapiens] 65 4e-11
gi|225579152 insulin-like growth factor binding protein, acid la... 65 6e-11
gi|4826772 insulin-like growth factor binding protein, acid labi... 65 6e-11
gi|188528675 slit homolog 1 [Homo sapiens] 64 1e-10
>gi|13562088 leucine-rich repeat-containing 3 precursor [Homo
sapiens]
Length = 257
Score = 526 bits (1355), Expect = e-150
Identities = 257/257 (100%), Positives = 257/257 (100%)
Query: 1 MGTVRPPRPSLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPE 60
MGTVRPPRPSLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPE
Sbjct: 1 MGTVRPPRPSLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPE 60
Query: 61 DIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDL 120
DIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDL
Sbjct: 61 DIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDL 120
Query: 121 SYNRIQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEF 180
SYNRIQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEF
Sbjct: 121 SYNRIQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEF 180
Query: 181 VGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYL 240
VGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYL
Sbjct: 181 VGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYL 240
Query: 241 KSLPSAPASKDPIGPGP 257
KSLPSAPASKDPIGPGP
Sbjct: 241 KSLPSAPASKDPIGPGP 257
>gi|16418445 leucine rich repeat containing 3B [Homo sapiens]
Length = 259
Score = 233 bits (595), Expect = 9e-62
Identities = 117/242 (48%), Positives = 160/242 (66%), Gaps = 2/242 (0%)
Query: 10 SLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLL 69
SL + +S + ++ C H + CP+ C C +G + V CS L+E+P D+P TVLL
Sbjct: 11 SLSMCLLLQSFVLMILCFHSASMCPKGCLCSS-SGGLNVTCSNANLKEIPRDLPPETVLL 69
Query: 70 KLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIP 129
LD+N+I+ +P+ F+ LH+LR L+LS N IE I F G+A L+ LDLS NRIQ +
Sbjct: 70 YLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFKGVAETLQTLDLSDNRIQSVH 129
Query: 130 KDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEFVGKPLVQAL 189
K+A L A+ R+++NP HC+C LQ+ L + + ++ + C TSV +E G+P + A
Sbjct: 130 KNAFNNLKARARIANNPWHCDCTLQQVLRSMASNHETAHNVICKTSVLDEHAGRPFLNAA 189
Query: 190 DAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYLKSLPSAPAS 249
+ A LC++P +TTD AMLVTMFGWF MVI+YVVYYVR NQEDARRHLEYLKSLPS
Sbjct: 190 N-DADLCNLPKKTTDYAMLVTMFGWFTMVISYVVYYVRQNQEDARRHLEYLKSLPSRQKK 248
Query: 250 KD 251
D
Sbjct: 249 AD 250
>gi|239756808 PREDICTED: similar to hCG2044133 [Homo sapiens]
Length = 275
Score = 168 bits (426), Expect = 4e-42
Identities = 98/244 (40%), Positives = 136/244 (55%), Gaps = 11/244 (4%)
Query: 11 LLLVSTRESCLFLLFCLHLGAACPQP------CRCPDHAGAVAVFCSLRGLQEVPEDIPA 64
+ ++ T L LL + G P P C AG CS GL VP IP
Sbjct: 20 MAMLPTAGHLLPLLLVIGTGGTVPSPQVPPRGCYVAKEAGERTFRCSQAGLSAVPSGIPN 79
Query: 65 NTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNR 124
+T L LDAN+++ +P GAFQHL L ELDLSHNA+ + A F GL G LR LDLS N+
Sbjct: 80 DTRKLYLDANQLASVPAGAFQHLPVLEELDLSHNALAHLSGAAFQGLEGTLRHLDLSANQ 139
Query: 125 IQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEFVGKP 184
+ +P +A L ++ LS NP HC+CALQE L +++L P + I C + + + VG+
Sbjct: 140 LASVPVEAFVGLQIQVNLSANPWHCDCALQEVLRQVRLVPGTGTGIVCGSGARPDLVGQE 199
Query: 185 LVQALDAGASLCSV----PHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYL 240
+ L LC R+TDVA+LVTM GW +++AY+V+YV N+++ RR L+
Sbjct: 200 FL-LLAGEEELCGSGWGGARRSTDVALLVTMGGWLTLMVAYLVHYVWQNRDETRRSLKRA 258
Query: 241 KSLP 244
LP
Sbjct: 259 PVLP 262
>gi|239751294 PREDICTED: similar to hCG2044133 [Homo sapiens]
Length = 275
Score = 168 bits (426), Expect = 4e-42
Identities = 98/244 (40%), Positives = 136/244 (55%), Gaps = 11/244 (4%)
Query: 11 LLLVSTRESCLFLLFCLHLGAACPQP------CRCPDHAGAVAVFCSLRGLQEVPEDIPA 64
+ ++ T L LL + G P P C AG CS GL VP IP
Sbjct: 20 MAMLPTAGHLLPLLLVIGTGGTVPSPQVPPRGCYVAKEAGERTFRCSQAGLSAVPSGIPN 79
Query: 65 NTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNR 124
+T L LDAN+++ +P GAFQHL L ELDLSHNA+ + A F GL G LR LDLS N+
Sbjct: 80 DTRKLYLDANQLASVPAGAFQHLPVLEELDLSHNALAHLSGAAFQGLEGTLRHLDLSANQ 139
Query: 125 IQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEFVGKP 184
+ +P +A L ++ LS NP HC+CALQE L +++L P + I C + + + VG+
Sbjct: 140 LASVPVEAFVGLQIQVNLSANPWHCDCALQEVLRQVRLVPGTGTGIVCGSGARPDLVGQE 199
Query: 185 LVQALDAGASLCSV----PHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYL 240
+ L LC R+TDVA+LVTM GW +++AY+V+YV N+++ RR L+
Sbjct: 200 FL-LLAGEEELCGSGWGGARRSTDVALLVTMGGWLTLMVAYLVHYVWQNRDETRRSLKRA 258
Query: 241 KSLP 244
LP
Sbjct: 259 PVLP 262
>gi|239745789 PREDICTED: hypothetical protein LOC728129 [Homo
sapiens]
Length = 275
Score = 168 bits (426), Expect = 4e-42
Identities = 98/244 (40%), Positives = 136/244 (55%), Gaps = 11/244 (4%)
Query: 11 LLLVSTRESCLFLLFCLHLGAACPQP------CRCPDHAGAVAVFCSLRGLQEVPEDIPA 64
+ ++ T L LL + G P P C AG CS GL VP IP
Sbjct: 20 MAMLPTAGHLLPLLLVIGTGGTVPSPQVPPRGCYVAKEAGERTFRCSQAGLSAVPSGIPN 79
Query: 65 NTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNR 124
+T L LDAN+++ +P GAFQHL L ELDLSHNA+ + A F GL G LR LDLS N+
Sbjct: 80 DTRKLYLDANQLASVPAGAFQHLPVLEELDLSHNALAHLSGAAFQGLEGTLRHLDLSANQ 139
Query: 125 IQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEFVGKP 184
+ +P +A L ++ LS NP HC+CALQE L +++L P + I C + + + VG+
Sbjct: 140 LASVPVEAFVGLQIQVNLSANPWHCDCALQEVLRQVRLVPGTGTGIVCGSGARPDLVGQE 199
Query: 185 LVQALDAGASLCSV----PHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYL 240
+ L LC R+TDVA+LVTM GW +++AY+V+YV N+++ RR L+
Sbjct: 200 FL-LLAGEEELCGSGWGGARRSTDVALLVTMGGWLTLMVAYLVHYVWQNRDETRRSLKRA 258
Query: 241 KSLP 244
LP
Sbjct: 259 PVLP 262
>gi|194306623 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 83.6 bits (205), Expect = 2e-16
Identities = 60/199 (30%), Positives = 85/199 (42%), Gaps = 54/199 (27%)
Query: 27 LHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQH 86
L + +CP+PC C D C+ + L+EVPE +PAN L L ANKI+ L GAF
Sbjct: 14 LGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFAD 73
Query: 87 ------------------------LHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSY 122
L +L+ LDLSHN I + + L+ L+LL +++
Sbjct: 74 VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLS-ALQLLKMNH 132
Query: 123 NRIQRIPKDALGKLS--------------------------AKIRLSHNPLHCECA---L 153
NR+ +P+DALG L + ++L HNP HC C L
Sbjct: 133 NRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWL 192
Query: 154 QEALWELKLDPDSVDEIAC 172
Q ++ D IAC
Sbjct: 193 QAWAASTRVSLPEPDSIAC 211
>gi|194306621 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 83.6 bits (205), Expect = 2e-16
Identities = 60/199 (30%), Positives = 85/199 (42%), Gaps = 54/199 (27%)
Query: 27 LHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQH 86
L + +CP+PC C D C+ + L+EVPE +PAN L L ANKI+ L GAF
Sbjct: 14 LGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFAD 73
Query: 87 ------------------------LHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSY 122
L +L+ LDLSHN I + + L+ L+LL +++
Sbjct: 74 VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLS-ALQLLKMNH 132
Query: 123 NRIQRIPKDALGKLS--------------------------AKIRLSHNPLHCECA---L 153
NR+ +P+DALG L + ++L HNP HC C L
Sbjct: 133 NRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWL 192
Query: 154 QEALWELKLDPDSVDEIAC 172
Q ++ D IAC
Sbjct: 193 QAWAASTRVSLPEPDSIAC 211
>gi|39930401 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 83.6 bits (205), Expect = 2e-16
Identities = 60/199 (30%), Positives = 85/199 (42%), Gaps = 54/199 (27%)
Query: 27 LHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQH 86
L + +CP+PC C D C+ + L+EVPE +PAN L L ANKI+ L GAF
Sbjct: 14 LGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFAD 73
Query: 87 ------------------------LHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSY 122
L +L+ LDLSHN I + + L+ L+LL +++
Sbjct: 74 VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLS-ALQLLKMNH 132
Query: 123 NRIQRIPKDALGKLS--------------------------AKIRLSHNPLHCECA---L 153
NR+ +P+DALG L + ++L HNP HC C L
Sbjct: 133 NRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWL 192
Query: 154 QEALWELKLDPDSVDEIAC 172
Q ++ D IAC
Sbjct: 193 QAWAASTRVSLPEPDSIAC 211
>gi|194306618 immunoglobulin superfamily containing leucine-rich
repeat 2 [Homo sapiens]
Length = 745
Score = 83.6 bits (205), Expect = 2e-16
Identities = 60/199 (30%), Positives = 85/199 (42%), Gaps = 54/199 (27%)
Query: 27 LHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQH 86
L + +CP+PC C D C+ + L+EVPE +PAN L L ANKI+ L GAF
Sbjct: 14 LGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFAD 73
Query: 87 ------------------------LHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSY 122
L +L+ LDLSHN I + + L+ L+LL +++
Sbjct: 74 VTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLS-ALQLLKMNH 132
Query: 123 NRIQRIPKDALGKLS--------------------------AKIRLSHNPLHCECA---L 153
NR+ +P+DALG L + ++L HNP HC C L
Sbjct: 133 NRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWL 192
Query: 154 QEALWELKLDPDSVDEIAC 172
Q ++ D IAC
Sbjct: 193 QAWAASTRVSLPEPDSIAC 211
>gi|41582239 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 83.6 bits (205), Expect = 2e-16
Identities = 50/153 (32%), Positives = 72/153 (47%), Gaps = 25/153 (16%)
Query: 21 LFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLP 80
L+ L L ACP+PC C + G C+ R L+ VP PAN L L AN++ LP
Sbjct: 7 LWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLP 66
Query: 81 DGAFQHLHRLRELDLSHNAIEAIGSATFAGLA-----------------------GGLRL 117
+GAF+ + L+ L L+HN I + + A L+ L+L
Sbjct: 67 EGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQL 126
Query: 118 LDLSYNRIQRIPKDALGKLSA--KIRLSHNPLH 148
L + N + IP+DA L A ++L+HN LH
Sbjct: 127 LKMDSNELTFIPRDAFRSLRALRSLQLNHNRLH 159
Score = 43.5 bits (101), Expect = 2e-04
Identities = 25/86 (29%), Positives = 39/86 (45%), Gaps = 23/86 (26%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
LLK+D+N+++ +P AF+ L LR L L+HN + + TF
Sbjct: 126 LLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT------------------ 167
Query: 128 IPKDALGKLSAKIRLSHNPLHCECAL 153
P AL L +++ NP C C +
Sbjct: 168 -PLTALSHL----QINENPFDCTCGI 188
>gi|5031809 immunoglobulin superfamily containing leucine-rich
repeat [Homo sapiens]
Length = 428
Score = 83.6 bits (205), Expect = 2e-16
Identities = 50/153 (32%), Positives = 72/153 (47%), Gaps = 25/153 (16%)
Query: 21 LFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLP 80
L+ L L ACP+PC C + G C+ R L+ VP PAN L L AN++ LP
Sbjct: 7 LWWALLLGLAQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLP 66
Query: 81 DGAFQHLHRLRELDLSHNAIEAIGSATFAGLA-----------------------GGLRL 117
+GAF+ + L+ L L+HN I + + A L+ L+L
Sbjct: 67 EGAFREVPLLQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQL 126
Query: 118 LDLSYNRIQRIPKDALGKLSA--KIRLSHNPLH 148
L + N + IP+DA L A ++L+HN LH
Sbjct: 127 LKMDSNELTFIPRDAFRSLRALRSLQLNHNRLH 159
Score = 43.5 bits (101), Expect = 2e-04
Identities = 25/86 (29%), Positives = 39/86 (45%), Gaps = 23/86 (26%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
LLK+D+N+++ +P AF+ L LR L L+HN + + TF
Sbjct: 126 LLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLHTLAEGTFT------------------ 167
Query: 128 IPKDALGKLSAKIRLSHNPLHCECAL 153
P AL L +++ NP C C +
Sbjct: 168 -PLTALSHL----QINENPFDCTCGI 188
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 71.6 bits (174), Expect = 6e-13
Identities = 43/110 (39%), Positives = 59/110 (53%), Gaps = 3/110 (2%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRE 92
CPQ C C + VA C + L EVP+ IP T L L N + +P AFQ + L
Sbjct: 33 CPQACICDNSRRHVA--CRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTH 90
Query: 93 LDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRL 142
LDL H +E + F GL G L LL+L+ N ++ +P++AL L + RL
Sbjct: 91 LDLRHCEVELVAEGAFRGL-GRLLLLNLASNHLRELPQEALDGLGSLRRL 139
Score = 55.1 bits (131), Expect = 6e-08
Identities = 34/81 (41%), Positives = 45/81 (55%), Gaps = 3/81 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N + +LP AFQ L R+R L LSHNA+ + AGL LR L L +N +Q +
Sbjct: 163 LNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLP-ALRRLSLHHNELQAL 221
Query: 129 PKDALGKLS--AKIRLSHNPL 147
P L + A++ L HNPL
Sbjct: 222 PGPVLSQARGLARLELGHNPL 242
Score = 50.4 bits (119), Expect = 1e-06
Identities = 48/150 (32%), Positives = 65/150 (43%), Gaps = 15/150 (10%)
Query: 31 AACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRL 90
A CP+ C C + + C GLQ VP P++T LL L N +P AF L L
Sbjct: 394 APCPRACVCVPESRHSS--CEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHL 451
Query: 91 RELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHNPLHCE 150
L L H I + + AGL G L L LS N++ + A L RL + L
Sbjct: 452 VSLHLQHCGIAELEAGALAGL-GRLIYLYLSDNQLAGLSAAA---LEGAPRLGYLYLERN 507
Query: 151 CALQ---------EALWELKLDPDSVDEIA 171
LQ +L+ L L ++VD +A
Sbjct: 508 RFLQVPGAALRALPSLFSLHLQDNAVDRLA 537
Score = 49.3 bits (116), Expect = 3e-06
Identities = 38/112 (33%), Positives = 50/112 (44%), Gaps = 29/112 (25%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHN-------------------------AIEAI 103
L LD N++ +P GA + L L EL LS N +E I
Sbjct: 574 LHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQI 633
Query: 104 GSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLSHNPLHCECAL 153
F+GL GL+ L L N+++ +P AL LS I LS NP HC+C L
Sbjct: 634 CPGAFSGLGPGLQSLHLQKNQLRALP--ALPSLSQLELIDLSSNPFHCDCQL 683
Score = 37.4 bits (85), Expect = 0.013
Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 3/90 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L+L N +++ + L LREL L A++A+G FA L LDL N++ +
Sbjct: 235 LELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAH-CPRLHTLDLRGNQLDTL 293
Query: 129 PK-DALGKLSAKIRLSHNPLHCECALQEAL 157
P G+L ++RL NPL C C + L
Sbjct: 294 PPLQGPGQL-RRLRLQGNPLWCGCQARPLL 322
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 71.6 bits (174), Expect = 6e-13
Identities = 44/116 (37%), Positives = 60/116 (51%), Gaps = 3/116 (2%)
Query: 32 ACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLR 91
ACP PC C + ++ CS GL VP D+ T L L N ++ L G F HL L
Sbjct: 34 ACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLE 93
Query: 92 ELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSA--KIRLSHN 145
EL LS N + I F+GL L++L L N++ IP +AL +L + +RL N
Sbjct: 94 ELRLSGNHLSHIPGQAFSGLY-SLKILMLQNNQLGGIPAEALWELPSLQSLRLDAN 148
Score = 53.5 bits (127), Expect = 2e-07
Identities = 33/79 (41%), Positives = 48/79 (60%), Gaps = 6/79 (7%)
Query: 55 LQEVP----EDIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAG 110
L E+P ++PA + L N+ISH+PD AFQ+L L L L +N I+ +G+ +F G
Sbjct: 174 LTEIPVRALNNLPALQAMT-LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEG 232
Query: 111 LAGGLRLLDLSYNRIQRIP 129
L L LDL+YN++Q P
Sbjct: 233 L-HNLETLDLNYNKLQEFP 250
Score = 46.2 bits (108), Expect = 3e-05
Identities = 41/118 (34%), Positives = 55/118 (46%), Gaps = 27/118 (22%)
Query: 51 SLRGLQEVPE--DIPANTVL--LKLDANKISHLPDGAFQHLHRLRELDLSHNAIE----- 101
SL G ++ E D+ T L L L I LP G Q L RLR L+LSHN IE
Sbjct: 311 SLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSL 370
Query: 102 -----------------AIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRL 142
IG+ TF+ L+ L+ LDLS+N I+ I +A L + ++L
Sbjct: 371 HRCQKLEEIGLQHNRIWEIGADTFSQLS-SLQALDLSWNAIRSIHPEAFSTLHSLVKL 427
Score = 42.4 bits (98), Expect = 4e-04
Identities = 30/78 (38%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L+LDAN IS +P+ +F+ L LR L L NA+ I L L+ + L+ NRI I
Sbjct: 143 LRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP-ALQAMTLALNRISHI 201
Query: 129 PKDALGKLSAKIRLS-HN 145
P A L++ + L HN
Sbjct: 202 PDYAFQNLTSLVVLHLHN 219
Score = 30.0 bits (66), Expect = 2.1
Identities = 27/70 (38%), Positives = 33/70 (47%), Gaps = 6/70 (8%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRI--Q 126
L L N I + AF LH L +LDL+ N + + AGL GGL L L N Q
Sbjct: 403 LDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGL-GGLMHLKLKGNLALSQ 458
Query: 127 RIPKDALGKL 136
KD+ KL
Sbjct: 459 AFSKDSFPKL 468
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 71.2 bits (173), Expect = 8e-13
Identities = 46/117 (39%), Positives = 59/117 (50%), Gaps = 5/117 (4%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRE 92
CP C C + V C+ RGL EVP+ IP+NT L L N I + F+HLH L
Sbjct: 46 CPSVCSCSNQFSKVV--CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEV 103
Query: 93 LDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLSHNPL 147
L L N+I I F GLA L L+L N + IP A LS ++ L +NP+
Sbjct: 104 LQLGRNSIRQIEVGAFNGLA-SLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPI 159
Score = 50.8 bits (120), Expect = 1e-06
Identities = 43/149 (28%), Positives = 75/149 (50%), Gaps = 13/149 (8%)
Query: 60 EDIPANTVLLKLDANKIS--HLPD---GAFQHLHRLRELDLSHNAIEAIGSATFAGLAGG 114
+D+P T L+ L+ ++S H P+ G+F L L++L + ++ + I F GLA
Sbjct: 209 KDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLAS- 267
Query: 115 LRLLDLSYNRIQRIPKDALGKLS--AKIRLSHNPLHCECALQEALWELK--LDPDSVDEI 170
L L+L++N + +P D L ++ L HNP +C+C + W L+ + +S
Sbjct: 268 LVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCG 327
Query: 171 ACHTSVQEEFVGKPLVQALDAGASLCSVP 199
CH + G+ LV+ +D + CS P
Sbjct: 328 RCHAPMHMR--GRYLVE-VDQASFQCSAP 353
>gi|38454322 adhesion molecule with Ig-like domain 3 [Homo sapiens]
Length = 504
Score = 70.5 bits (171), Expect = 1e-12
Identities = 44/121 (36%), Positives = 63/121 (52%), Gaps = 8/121 (6%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRE 92
CP C C A + C+ GLQ+VP ++PA T L L N + L G L +LR
Sbjct: 34 CPYKCIC----AADLLSCTGLGLQDVPAELPAATADLDLSHNALQRLRPGWLAPLFQLRA 89
Query: 93 LDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPK---DALGKLSAKIRLSHNPLHC 149
L L HN ++A+G F A GLRLLDLS N ++ + + D LG L + ++ +H
Sbjct: 90 LHLDHNELDALGRGVFVN-ASGLRLLDLSSNTLRALGRHDLDGLGALEKLLLFNNRLVHL 148
Query: 150 E 150
+
Sbjct: 149 D 149
Score = 43.1 bits (100), Expect = 2e-04
Identities = 34/94 (36%), Positives = 44/94 (46%), Gaps = 5/94 (5%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGL-AGGLRLLDLSYNRIQR 127
L L N++ HL + AF L L L L N + + GL A L LDLS NR+
Sbjct: 138 LLLFNNRLVHLDEHAFHGLRALSHLYLGCNELASFSFDHLHGLSATHLLTLDLSSNRLGH 197
Query: 128 IPKDALGKLSAKIR----LSHNPLHCECALQEAL 157
I L L A ++ L +NPL C+C L L
Sbjct: 198 ISVPELAALPAFLKNGLYLHNNPLPCDCRLYHLL 231
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 67.8 bits (164), Expect = 9e-12
Identities = 57/187 (30%), Positives = 90/187 (48%), Gaps = 17/187 (9%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRE 92
C PC C G V CS +GL VPE + A T L + N I+ LP+ AF++ L E
Sbjct: 29 CAAPCSCD---GDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEE 85
Query: 93 LDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHNPLHCECA 152
L L+ N + I +GL L++L L N+++ +P +A+ LSA L + H
Sbjct: 86 LQLAGNDLSFIHPKALSGLK-ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSV 144
Query: 153 LQEA------LWELKLDPDSVDEIACHTSVQEEFVGKPLVQALDAGAS-LCSVP-HRTTD 204
+++ L L LD +S+ E+ H P +QAL + + S+P T+
Sbjct: 145 PEDSFEGLVQLRHLWLDDNSLTEVPVH-----PLSNLPTLQALTLALNKISSIPDFAFTN 199
Query: 205 VAMLVTM 211
++ LV +
Sbjct: 200 LSSLVVL 206
Score = 47.0 bits (110), Expect = 2e-05
Identities = 28/69 (40%), Positives = 38/69 (55%), Gaps = 1/69 (1%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
+ L N+I + +G FQ L LR LDLS N I I S FA L G + LD+S+N +
Sbjct: 370 ISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATL-GPITNLDVSFNELTSF 428
Query: 129 PKDALGKLS 137
P + L L+
Sbjct: 429 PTEGLNGLN 437
Score = 43.9 bits (102), Expect = 1e-04
Identities = 31/79 (39%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 55 LQEVPEDIPANTVLLK---LDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGL 111
L EVP +N L+ L NKIS +PD AF +L L L L +N I ++ F GL
Sbjct: 165 LTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGL 224
Query: 112 AGGLRLLDLSYNRIQRIPK 130
L LDL+YN + P+
Sbjct: 225 -DNLETLDLNYNNLGEFPQ 242
Score = 40.8 bits (94), Expect = 0.001
Identities = 29/68 (42%), Positives = 32/68 (47%), Gaps = 3/68 (4%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N I LP +F H L E+ L N I I TF GL LR+LDLS N I I
Sbjct: 348 LDLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLI-SLRILDLSRNLIHEI 404
Query: 129 PKDALGKL 136
A L
Sbjct: 405 HSRAFATL 412
Score = 37.0 bits (84), Expect = 0.017
Identities = 37/132 (28%), Positives = 59/132 (44%), Gaps = 16/132 (12%)
Query: 55 LQEVPEDIPANTVLLKLD--ANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLA 112
L E P+ I A L +L +N IS +PDGAF LR + L N + +G++ F L+
Sbjct: 237 LGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLS 296
Query: 113 GGLRLLDLSYNRIQRIPK-------DALGKLSAKIRLSHNPLHCECALQEALWELKLDPD 165
L+ + +Q+ P ++L KI N L C Q+ L L L +
Sbjct: 297 DLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNL---CQEQKMLRTLDLSYN 353
Query: 166 SVDEI----ACH 173
++ ++ CH
Sbjct: 354 NIRDLPSFNGCH 365
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 67.4 bits (163), Expect = 1e-11
Identities = 49/147 (33%), Positives = 69/147 (46%), Gaps = 30/147 (20%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDAN------------------ 74
CP C C D V CS +GL+ +P+ IP + L LD N
Sbjct: 727 CPTECTCLD----TVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLI 782
Query: 75 -----KISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIP 129
+IS L + +F ++ +L L LS+N + I TF GL LRLL L N I +P
Sbjct: 783 DLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLK-SLRLLSLHGNDISVVP 841
Query: 130 KDALGKLSA--KIRLSHNPLHCECALQ 154
+ A LSA + + NPL+C+C +Q
Sbjct: 842 EGAFNDLSALSHLAIGANPLYCDCNMQ 868
Score = 63.9 bits (154), Expect = 1e-10
Identities = 41/128 (32%), Positives = 60/128 (46%), Gaps = 5/128 (3%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRE 92
CP C C ++ V C +GL E+P ++P ++L+ N I +P GAF +LR
Sbjct: 273 CPAACTCSNNI----VDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRR 328
Query: 93 LDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHNPLHCECA 152
+DLS+N I + F GL L L L N+I +PK L + L N C
Sbjct: 329 IDLSNNQISELAPDAFQGLR-SLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCL 387
Query: 153 LQEALWEL 160
+A +L
Sbjct: 388 RVDAFQDL 395
Score = 57.8 bits (138), Expect = 9e-09
Identities = 48/144 (33%), Positives = 63/144 (43%), Gaps = 31/144 (21%)
Query: 32 ACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTV------------------------ 67
ACP C C V C L+ VP +IP NT
Sbjct: 27 ACPAQCSC----SGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLR 82
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
+L+L NKIS + GAFQ L L L L+ N ++ F G A L LDLS N+IQ
Sbjct: 83 VLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTA-KLYRLDLSENQIQA 141
Query: 128 IPKDAL-GKLSAK-IRLSHNPLHC 149
IP+ A G + K ++L +N + C
Sbjct: 142 IPRKAFRGAVDIKNLQLDYNQISC 165
Score = 52.0 bits (123), Expect = 5e-07
Identities = 49/173 (28%), Positives = 69/173 (39%), Gaps = 56/173 (32%)
Query: 32 ACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDAN----------------- 74
ACP+ CRC V CS + L ++PE IP T L+L+ N
Sbjct: 505 ACPEKCRCE----GTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQL 560
Query: 75 --------KISHLPDGAF-------------------QH-----LHRLRELDLSHNAIEA 102
KI+ + +GAF QH L L+ L L N I
Sbjct: 561 RKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITC 620
Query: 103 IGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLSHNPLHCECAL 153
+G+ +F GL+ +RLL L N+I + A L + + L NP +C C L
Sbjct: 621 VGNDSFIGLS-SVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYL 672
Score = 39.3 bits (90), Expect = 0.003
Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 3/87 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N+I +P AF+ ++ L L +N I I F L L +L L+ N I R+
Sbjct: 132 LDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALR-DLEVLTLNNNNITRL 190
Query: 129 PKDALGKLS--AKIRLSHNPLHCECAL 153
+ + RL N L+C+C L
Sbjct: 191 SVASFNHMPKLRTFRLHSNNLYCDCHL 217
Score = 38.5 bits (88), Expect = 0.006
Identities = 30/105 (28%), Positives = 41/105 (39%), Gaps = 23/105 (21%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
LL L+ANKI+ L AFQ LH L L L N ++ I TF+ L
Sbjct: 376 LLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPL---------------- 419
Query: 128 IPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIAC 172
+ + L+ NP C+C L+ L +P C
Sbjct: 420 -------RAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARC 457
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 67.4 bits (163), Expect = 1e-11
Identities = 44/118 (37%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 32 ACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLR 91
+CP C C + A V C+ R L EVP IP NT L L N I + F+HL L
Sbjct: 56 SCPVACSCSNQASRV--ICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLE 113
Query: 92 ELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLSHNPL 147
L LS N + I F GL L L+L NR+ +P A LS ++ L +NP+
Sbjct: 114 ILQLSKNLVRKIEVGAFNGLP-SLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPI 170
Score = 57.0 bits (136), Expect = 2e-08
Identities = 37/109 (33%), Positives = 55/109 (50%), Gaps = 8/109 (7%)
Query: 60 EDIPANTVLLKLD-----ANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGG 114
+DIP T L++L+ N++ + G+FQ L LR+L L H + I F L
Sbjct: 220 KDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKS- 278
Query: 115 LRLLDLSYNRIQRIPKDALGKLSA--KIRLSHNPLHCECALQEALWELK 161
L L+LS+N + +P D L ++ L+HNP HC C + W LK
Sbjct: 279 LEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLK 327
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 67.4 bits (163), Expect = 1e-11
Identities = 45/117 (38%), Positives = 59/117 (50%), Gaps = 5/117 (4%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRE 92
CP C C + V C + L+EVP+ I NT LL L N+I + +F+HL L
Sbjct: 47 CPSVCSCSNQFSKV--ICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEI 104
Query: 93 LDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLSHNPL 147
L LS N I I F GLA L L+L NR+ IP A LS ++ L +NP+
Sbjct: 105 LQLSRNHIRTIEIGAFNGLA-NLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPI 160
Score = 48.9 bits (115), Expect = 4e-06
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 15/119 (12%)
Query: 50 CSLRGLQEVPEDIPANTVLLKLD-----ANKISHLPDGAFQHLHRLRELDLSHNAIEAIG 104
C+LR +IP T L+KLD N +S + G+FQ L L++L + + I+ I
Sbjct: 207 CNLR-------EIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIE 259
Query: 105 SATFAGLAGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLSHNPLHCECALQEALWELK 161
F L L ++L++N + +P D L +I L HNP +C C + W +K
Sbjct: 260 RNAFDNLQS-LVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIK 317
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 67.0 bits (162), Expect = 2e-11
Identities = 42/115 (36%), Positives = 60/115 (52%), Gaps = 3/115 (2%)
Query: 19 SCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISH 78
+C L+ + CP C+C + + V CS GL VP D+PA T L L NK+S
Sbjct: 25 TCWIALYAVEALPTCPFSCKCDSRS--LEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSA 82
Query: 79 LPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDAL 133
LP AF +L L+ LDLS+N ++ + + F L L L L N I+ + +D L
Sbjct: 83 LPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLT-NLTELQLRNNSIRTLDRDLL 136
Score = 34.3 bits (77), Expect = 0.11
Identities = 26/87 (29%), Positives = 36/87 (41%), Gaps = 23/87 (26%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N ++ LP G F L LR L L N ++ + TF LA L+LL
Sbjct: 145 LDLSINGLAQLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLA-NLQLL---------- 193
Query: 129 PKDALGKLSAKIRLSHNPLHCECALQE 155
++ NP C+C L+E
Sbjct: 194 ------------QVGDNPWECDCNLRE 208
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 67.0 bits (162), Expect = 2e-11
Identities = 54/136 (39%), Positives = 66/136 (48%), Gaps = 11/136 (8%)
Query: 20 CLFLLFCLHLGAA------CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDA 73
C+ L L L AA CP C C AVA C+ R L VP+ IPA T LL+L
Sbjct: 6 CVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVA--CTRRRLTAVPDGIPAETRLLELSR 63
Query: 74 NKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDAL 133
N+I L G L L ELDLS NAI + FA L LR+L L N+++ IP
Sbjct: 64 NRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLP-RLRVLRLRGNQLKLIPPGVF 122
Query: 134 GKLS--AKIRLSHNPL 147
+L + LS N L
Sbjct: 123 TRLDNLTLLDLSENKL 138
Score = 51.6 bits (122), Expect = 7e-07
Identities = 34/97 (35%), Positives = 51/97 (52%), Gaps = 6/97 (6%)
Query: 64 ANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYN 123
A+ L L N IS +P G+F+ L RLREL L+ + + F GL +RLL+LS N
Sbjct: 270 AHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLR-QIRLLNLSNN 328
Query: 124 RIQRIPKDALGKLSA--KIRLSHNPLHCECALQEALW 158
+ + + ++ +R+ NPL C+C L LW
Sbjct: 329 LLSTLEESTFHSVNTLETLRVDGNPLACDCRL---LW 362
Score = 41.2 bits (95), Expect = 9e-04
Identities = 29/82 (35%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 65 NTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNR 124
N LL L NK+ L D FQ LH LR L++ N + + FAGL L L L
Sbjct: 127 NLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLL-ALEELTLERCN 185
Query: 125 IQRIPKDALGKLSA--KIRLSH 144
+ + ++LG L + +RL H
Sbjct: 186 LTALSGESLGHLRSLGALRLRH 207
>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
Length = 341
Score = 67.0 bits (162), Expect = 2e-11
Identities = 50/145 (34%), Positives = 69/145 (47%), Gaps = 13/145 (8%)
Query: 6 PPRPSLLLVSTRESCLFLLFCLH--LGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIP 63
PP P++LL+S L +H G +CP C C + V CS + L VP D+P
Sbjct: 56 PPHPAMLLISL----LLAAGLMHSDAGTSCPVLCTCRNQV----VDCSSQRLFSVPPDLP 107
Query: 64 ANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYN 123
+T L L N+I+ +P G L+ LDL +N++ + F A L LDLSYN
Sbjct: 108 MDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFLH-AKRLAHLDLSYN 166
Query: 124 RIQRIPKDALGKLS--AKIRLSHNP 146
+P D + I LSHNP
Sbjct: 167 NFSHVPADMFQEAHGLVHIDLSHNP 191
Score = 28.1 bits (61), Expect = 7.9
Identities = 33/142 (23%), Positives = 51/142 (35%), Gaps = 27/142 (19%)
Query: 83 AFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRL 142
AFQ L +LR+LDLS+ + + GL G + L ++
Sbjct: 200 AFQGLMQLRDLDLSYGGLAFLSLEALEGLPGLVTL-----------------------QI 236
Query: 143 SHNPLHCECALQEALWEL--KLDPDSVDEIACHTSVQEEFVGKPLVQALDAGASLCSVPH 200
NP C C ++ L L ++ + D E G PL + C +
Sbjct: 237 GGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGPPEVEGAPLFSLTEESFKACHLT- 295
Query: 201 RTTDVAMLVTMFGWFAMVIAYV 222
T D + + G F + IA V
Sbjct: 296 LTLDDYLFIAFVG-FVVSIASV 316
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 66.6 bits (161), Expect = 2e-11
Identities = 45/124 (36%), Positives = 62/124 (50%), Gaps = 4/124 (3%)
Query: 21 LFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLP 80
L LL AACP PC C + + +++ C+ RGL VP ++ TV L+L N I L
Sbjct: 5 LLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALG 64
Query: 81 DGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKI 140
F+++ L +L LS NAI IG+ F L LR L L NR+ + G L +
Sbjct: 65 PPDFRNMTGLVDLTLSRNAITRIGARAFGDLE-SLRSLHLDGNRLVEL---GTGSLRGPV 120
Query: 141 RLSH 144
L H
Sbjct: 121 NLQH 124
Score = 40.0 bits (92), Expect = 0.002
Identities = 42/126 (33%), Positives = 54/126 (42%), Gaps = 25/126 (19%)
Query: 51 SLRGLQEVP-EDIPANTVL--LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSAT 107
S L++VP I A L L LD N I LP GAF L +L LDL+ N
Sbjct: 153 SYNNLRQVPWAGIGAMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSN--------- 203
Query: 108 FAGLAGGLRLLDLSYNRIQRIPKDA-LGKLSAKIRLSHNPLHCECALQEALWELKL-DPD 165
RL L+ + + +DA + S NPLHC C E LW +L PD
Sbjct: 204 --------RLATLAPDPLFSRGRDAEASPAPLVLSFSGNPLHCNC---ELLWLRRLARPD 252
Query: 166 SVDEIA 171
++ A
Sbjct: 253 DLETCA 258
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 66.2 bits (160), Expect = 3e-11
Identities = 43/119 (36%), Positives = 63/119 (52%), Gaps = 6/119 (5%)
Query: 29 LGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLH 88
LG CP C+C H V CS GL +VP+D+P +T LL L NKI+ + DG F++L
Sbjct: 50 LGPVCPFRCQC--HLRVVQ--CSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLK 105
Query: 89 RLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHNPL 147
L L L +N I + F L L L LS N+++ +P + + K ++R N +
Sbjct: 106 NLHALILVNNKISKVSPGAFTPLV-KLERLYLSKNQLKELP-EKMPKTLQELRAHENEI 162
Score = 46.2 bits (108), Expect = 3e-05
Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 1/75 (1%)
Query: 55 LQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGG 114
+ +P+ +P + L LD NKIS + + + L+ L +L LS N+I A+ + + A
Sbjct: 212 ITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLAN-TPH 270
Query: 115 LRLLDLSYNRIQRIP 129
LR L L N++ R+P
Sbjct: 271 LRELHLDNNKLTRVP 285
Score = 32.0 bits (71), Expect = 0.54
Identities = 42/187 (22%), Positives = 74/187 (39%), Gaps = 33/187 (17%)
Query: 48 VFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSAT 107
++ S L+E+PE +P L+ N+I+ + F L+++ ++L N +++ G
Sbjct: 134 LYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIEN 193
Query: 108 FA----------------------GLAGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLS 143
A GL L L L N+I R+ +L L+ AK+ LS
Sbjct: 194 GAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLS 253
Query: 144 HNPLHC----ECALQEALWELKLDPDSVDEI----ACHTSVQEEFVGKPLVQALDAGASL 195
N + A L EL LD + + + A H +Q ++ + + +
Sbjct: 254 FNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVV-GSSDF 312
Query: 196 CSVPHRT 202
C H T
Sbjct: 313 CPPGHNT 319
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 66.2 bits (160), Expect = 3e-11
Identities = 43/119 (36%), Positives = 63/119 (52%), Gaps = 6/119 (5%)
Query: 29 LGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLH 88
LG CP C+C H V CS GL +VP+D+P +T LL L NKI+ + DG F++L
Sbjct: 50 LGPVCPFRCQC--HLRVVQ--CSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLK 105
Query: 89 RLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHNPL 147
L L L +N I + F L L L LS N+++ +P + + K ++R N +
Sbjct: 106 NLHALILVNNKISKVSPGAFTPLV-KLERLYLSKNQLKELP-EKMPKTLQELRAHENEI 162
Score = 46.2 bits (108), Expect = 3e-05
Identities = 25/75 (33%), Positives = 42/75 (56%), Gaps = 1/75 (1%)
Query: 55 LQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGG 114
+ +P+ +P + L LD NKIS + + + L+ L +L LS N+I A+ + + A
Sbjct: 212 ITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLAN-TPH 270
Query: 115 LRLLDLSYNRIQRIP 129
LR L L N++ R+P
Sbjct: 271 LRELHLDNNKLTRVP 285
Score = 32.0 bits (71), Expect = 0.54
Identities = 42/187 (22%), Positives = 74/187 (39%), Gaps = 33/187 (17%)
Query: 48 VFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSAT 107
++ S L+E+PE +P L+ N+I+ + F L+++ ++L N +++ G
Sbjct: 134 LYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIEN 193
Query: 108 FA----------------------GLAGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLS 143
A GL L L L N+I R+ +L L+ AK+ LS
Sbjct: 194 GAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLS 253
Query: 144 HNPLHC----ECALQEALWELKLDPDSVDEI----ACHTSVQEEFVGKPLVQALDAGASL 195
N + A L EL LD + + + A H +Q ++ + + +
Sbjct: 254 FNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVV-GSSDF 312
Query: 196 CSVPHRT 202
C H T
Sbjct: 313 CPPGHNT 319
>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
Length = 513
Score = 65.5 bits (158), Expect = 4e-11
Identities = 43/104 (41%), Positives = 61/104 (58%), Gaps = 3/104 (2%)
Query: 52 LRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGL 111
LRGL+ A +L L N+++ L D F HL RL+EL L N+IE + AGL
Sbjct: 110 LRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGL 169
Query: 112 AGGLRLLDLSYNRIQRIPKDALGKLSA--KIRLSHNPLHCECAL 153
+ L LLDLS N++ I ++AL L++ +RL+ NP C+CAL
Sbjct: 170 S-SLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCAL 212
Score = 48.9 bits (115), Expect = 4e-06
Identities = 40/111 (36%), Positives = 52/111 (46%), Gaps = 6/111 (5%)
Query: 23 LLFCLHLGAA-CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPD 81
LL L L AA CP CRC + V C L+ VP IP T L L N I+ L
Sbjct: 12 LLLLLPLRAAGCPAACRC----YSATVECGALRLRVVPLGIPPGTQTLFLQDNNIARLEP 67
Query: 82 GAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDA 132
GA L LR L L +N++ A+ + F L L L+ NR++ + A
Sbjct: 68 GALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELA-LTSNRLRGLRSGA 117
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 65.5 bits (158), Expect = 4e-11
Identities = 42/121 (34%), Positives = 62/121 (51%), Gaps = 9/121 (7%)
Query: 32 ACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLR 91
+CP PC C ++ V C +GL E+P ++P V ++L+ N I +P GAF +L+
Sbjct: 279 SCPSPCTCSNNI----VDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK 334
Query: 92 ELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPK---DALGKLSAKIRLSHNPLH 148
+D+S N I I F GL L L L N+I I K D L L + L+ N ++
Sbjct: 335 RIDISKNQISDIAPDAFQGLK-SLTSLVLYGNKITEIAKGLFDGLVSLQL-LLLNANKIN 392
Query: 149 C 149
C
Sbjct: 393 C 393
Score = 63.5 bits (153), Expect = 2e-10
Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 32/152 (21%)
Query: 29 LGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLH 88
L CP+ C C + V CS +GL+ +P +P + L L+ N ++ +P L
Sbjct: 721 LSPRCPEQCTCME----TVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR-ELSALR 775
Query: 89 RLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDAL--------------- 133
L +DLS+N+I + + TF+ ++ L L LSYNR++ IP A
Sbjct: 776 HLTLIDLSNNSISMLTNYTFSNMSH-LSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGND 834
Query: 134 ------GKLSAKIRLSH-----NPLHCECALQ 154
G + LSH NPLHC+C+L+
Sbjct: 835 ISSVPEGSFNDLTSLSHLALGTNPLHCDCSLR 866
Score = 57.8 bits (138), Expect = 9e-09
Identities = 47/144 (32%), Positives = 63/144 (43%), Gaps = 31/144 (21%)
Query: 32 ACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKIS-------------- 77
ACP C C A +V C GL+ VP IP N L LD N I+
Sbjct: 33 ACPTKCTC----SAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLR 88
Query: 78 --HLPD--------GAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
HL D GAFQ L +L L L+ N ++ + F L LDLS N+IQ
Sbjct: 89 VLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQS-TPKLTRLDLSENQIQG 147
Query: 128 IPKDALGKLS--AKIRLSHNPLHC 149
IP+ A ++ ++L +N + C
Sbjct: 148 IPRKAFRGITDVKNLQLDNNHISC 171
Score = 48.1 bits (113), Expect = 7e-06
Identities = 45/171 (26%), Positives = 61/171 (35%), Gaps = 54/171 (31%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPA-------------------------NTV 67
CP+ CRC V CS + L +P +P N
Sbjct: 505 CPEKCRCE----GTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLR 560
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAG-------------- 113
+ L NKI + +GAF ++EL L+ N +E + F GL+G
Sbjct: 561 KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCV 620
Query: 114 ---------GLRLLDLSYNRIQRIPKDALGKL--SAKIRLSHNPLHCECAL 153
+RLL L NRI I A L + I L NP +C C L
Sbjct: 621 SNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHL 671
Score = 42.7 bits (99), Expect = 3e-04
Identities = 33/104 (31%), Positives = 50/104 (48%), Gaps = 6/104 (5%)
Query: 55 LQEVPEDIPANT---VLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGL 111
LQ +PE + +T L L N+I +P AF+ + ++ L L +N I I F L
Sbjct: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180
Query: 112 AGGLRLLDLSYNRIQRIPKDALGKLS--AKIRLSHNPLHCECAL 153
L +L L+ N I RI + + +RL N L+C+C L
Sbjct: 181 R-DLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHL 223
Score = 32.7 bits (73), Expect = 0.32
Identities = 22/56 (39%), Positives = 29/56 (51%), Gaps = 1/56 (1%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYN 123
LL L+ANKI+ L FQ L L L L N ++ I FA L ++ L L+ N
Sbjct: 383 LLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQ-SIQTLHLAQN 437
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 65.1 bits (157), Expect = 6e-11
Identities = 52/149 (34%), Positives = 75/149 (50%), Gaps = 15/149 (10%)
Query: 30 GAACPQPCRCP--DHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHL 87
G ACP C C D A ++VFCS R L +P+ +P T L LD N +S +P AFQ+L
Sbjct: 76 GPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNL 135
Query: 88 HRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLS-----AKIRL 142
L L+L + ++ GL L L L N+++ + ALG + A + L
Sbjct: 136 SSLGFLNLQGGQLGSLEPQALLGLE-NLCHLHLERNQLRSL---ALGTFAHTPALASLGL 191
Query: 143 SHNPL-HCECALQE---ALWELKLDPDSV 167
S+N L E L E +LW+L L +S+
Sbjct: 192 SNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
Score = 48.1 bits (113), Expect = 7e-06
Identities = 33/79 (41%), Positives = 43/79 (54%), Gaps = 3/79 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L LD N I+ + GAF L LR LDLSHN + + TF GL GLR+L LS+N I +
Sbjct: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLRVLRLSHNAIASL 343
Query: 129 PKDALGKLS--AKIRLSHN 145
L +++L HN
Sbjct: 344 RPRTFKDLHFLEELQLGHN 362
Score = 46.2 bits (108), Expect = 3e-05
Identities = 31/82 (37%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
+L+L N I+ L F+ LH L EL L HN I + +F GL G L +L L +N++Q
Sbjct: 332 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL-GQLEVLTLDHNQLQE 390
Query: 128 IPKDALGKLS--AKIRLSHNPL 147
+ A L+ A + LS N L
Sbjct: 391 VKAGAFLGLTNVAVMNLSGNCL 412
Score = 43.9 bits (102), Expect = 1e-04
Identities = 29/68 (42%), Positives = 40/68 (58%), Gaps = 1/68 (1%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N ++ LPD AF+ L LREL L+ N + + A F+GLA LR LDLS N ++ I
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLA-ELRELDLSRNALRAI 271
Query: 129 PKDALGKL 136
+ +L
Sbjct: 272 KANVFVQL 279
Score = 43.5 bits (101), Expect = 2e-04
Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 3/86 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N+++ LP A L R LD+SHN +EA+ ++ A L G LR L L N ++
Sbjct: 501 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPL-GRLRYLSLRNNSLRTF 559
Query: 129 PKDALGKLSAKIRLSHNPLHCECALQ 154
G ++ L NP C C L+
Sbjct: 560 TPQPPG--LERLWLEGNPWDCGCPLK 583
Score = 40.4 bits (93), Expect = 0.002
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N++S L DG F+ L L +L+L N++ + A F GL G LR L L+ NR+ +
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL-GSLRELVLAGNRLAYL 247
Query: 129 PKDALGKLS--AKIRLSHNPL 147
L+ ++ LS N L
Sbjct: 248 QPALFSGLAELRELDLSRNAL 268
Score = 39.7 bits (91), Expect = 0.003
Identities = 34/124 (27%), Positives = 51/124 (41%), Gaps = 30/124 (24%)
Query: 65 NTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRL------- 117
N ++ L N + +LP+ F+ L +L L L + + I TF GL+G RL
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
Query: 118 ----------------LDLSYNRIQRIPK---DALGKLS----AKIRLSHNPLHCECALQ 154
LDL+ N++ +P LGKL ++ RL+ P LQ
Sbjct: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
Query: 155 EALW 158
A W
Sbjct: 521 RAFW 524
Score = 31.6 bits (70), Expect = 0.71
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 1/93 (1%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
+L LD N++ + GAF L + ++LS N + + F GL G L L L + + R
Sbjct: 380 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL-GKLHSLHLEGSCLGR 438
Query: 128 IPKDALGKLSAKIRLSHNPLHCECALQEALWEL 160
I LS RL +++LW L
Sbjct: 439 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 471
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 65.1 bits (157), Expect = 6e-11
Identities = 52/149 (34%), Positives = 75/149 (50%), Gaps = 15/149 (10%)
Query: 30 GAACPQPCRCP--DHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHL 87
G ACP C C D A ++VFCS R L +P+ +P T L LD N +S +P AFQ+L
Sbjct: 38 GPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNL 97
Query: 88 HRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLS-----AKIRL 142
L L+L + ++ GL L L L N+++ + ALG + A + L
Sbjct: 98 SSLGFLNLQGGQLGSLEPQALLGLE-NLCHLHLERNQLRSL---ALGTFAHTPALASLGL 153
Query: 143 SHNPL-HCECALQE---ALWELKLDPDSV 167
S+N L E L E +LW+L L +S+
Sbjct: 154 SNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
Score = 48.1 bits (113), Expect = 7e-06
Identities = 33/79 (41%), Positives = 43/79 (54%), Gaps = 3/79 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L LD N I+ + GAF L LR LDLSHN + + TF GL GLR+L LS+N I +
Sbjct: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLRVLRLSHNAIASL 305
Query: 129 PKDALGKLS--AKIRLSHN 145
L +++L HN
Sbjct: 306 RPRTFKDLHFLEELQLGHN 324
Score = 46.2 bits (108), Expect = 3e-05
Identities = 31/82 (37%), Positives = 44/82 (53%), Gaps = 3/82 (3%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
+L+L N I+ L F+ LH L EL L HN I + +F GL G L +L L +N++Q
Sbjct: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL-GQLEVLTLDHNQLQE 352
Query: 128 IPKDALGKLS--AKIRLSHNPL 147
+ A L+ A + LS N L
Sbjct: 353 VKAGAFLGLTNVAVMNLSGNCL 374
Score = 43.9 bits (102), Expect = 1e-04
Identities = 29/68 (42%), Positives = 40/68 (58%), Gaps = 1/68 (1%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N ++ LPD AF+ L LREL L+ N + + A F+GLA LR LDLS N ++ I
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLA-ELRELDLSRNALRAI 233
Query: 129 PKDALGKL 136
+ +L
Sbjct: 234 KANVFVQL 241
Score = 43.5 bits (101), Expect = 2e-04
Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 3/86 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N+++ LP A L R LD+SHN +EA+ ++ A L G LR L L N ++
Sbjct: 463 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPL-GRLRYLSLRNNSLRTF 521
Query: 129 PKDALGKLSAKIRLSHNPLHCECALQ 154
G ++ L NP C C L+
Sbjct: 522 TPQPPG--LERLWLEGNPWDCGCPLK 545
Score = 40.4 bits (93), Expect = 0.002
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRI 128
L L N++S L DG F+ L L +L+L N++ + A F GL G LR L L+ NR+ +
Sbjct: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL-GSLRELVLAGNRLAYL 209
Query: 129 PKDALGKLS--AKIRLSHNPL 147
L+ ++ LS N L
Sbjct: 210 QPALFSGLAELRELDLSRNAL 230
Score = 39.7 bits (91), Expect = 0.003
Identities = 34/124 (27%), Positives = 51/124 (41%), Gaps = 30/124 (24%)
Query: 65 NTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRL------- 117
N ++ L N + +LP+ F+ L +L L L + + I TF GL+G RL
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
Query: 118 ----------------LDLSYNRIQRIPK---DALGKLS----AKIRLSHNPLHCECALQ 154
LDL+ N++ +P LGKL ++ RL+ P LQ
Sbjct: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
Query: 155 EALW 158
A W
Sbjct: 483 RAFW 486
Score = 31.6 bits (70), Expect = 0.71
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 1/93 (1%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
+L LD N++ + GAF L + ++LS N + + F GL G L L L + + R
Sbjct: 342 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL-GKLHSLHLEGSCLGR 400
Query: 128 IPKDALGKLSAKIRLSHNPLHCECALQEALWEL 160
I LS RL +++LW L
Sbjct: 401 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 433
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 64.3 bits (155), Expect = 1e-10
Identities = 42/136 (30%), Positives = 61/136 (44%), Gaps = 5/136 (3%)
Query: 26 CLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQ 85
C +CP C C + V C +GL +P ++P ++L+ N I +P GAF
Sbjct: 275 CTLSSGSCPAMCTCSNGI----VDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFS 330
Query: 86 HLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHN 145
+LR +DLS+N I I F GL L L L N+I +P+ G L L N
Sbjct: 331 PYRKLRRIDLSNNQIAEIAPDAFQGLR-SLNSLVLYGNKITDLPRGVFGGLYTLQLLLLN 389
Query: 146 PLHCECALQEALWELK 161
C +A +L+
Sbjct: 390 ANKINCIRPDAFQDLQ 405
Score = 63.9 bits (154), Expect = 1e-10
Identities = 46/147 (31%), Positives = 68/147 (46%), Gaps = 30/147 (20%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDAN------------------ 74
CPQ C C D V CS + L+ +P+ IP N L LD N
Sbjct: 734 CPQECACLD----TVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLV 789
Query: 75 -----KISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQRIP 129
KIS L + +F ++ +L L LS+NA++ I F GL LRLL L N I +
Sbjct: 790 DLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLR-SLRLLSLHGNDISTLQ 848
Query: 130 KDALGKLS--AKIRLSHNPLHCECALQ 154
+ ++ + + + NPL+C+C L+
Sbjct: 849 EGIFADVTSLSHLAIGANPLYCDCHLR 875
Score = 58.2 bits (139), Expect = 7e-09
Identities = 44/125 (35%), Positives = 57/125 (45%), Gaps = 30/125 (24%)
Query: 33 CPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPANTVLLKLDAN------------------ 74
CP CRC A V CS L ++PE IP +T L+L+ N
Sbjct: 513 CPHKCRCE----ANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLK 568
Query: 75 -------KISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
K+S + DGAF+ + EL L+ N +E+I S F GL GLR L L NRI
Sbjct: 569 KINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGL-DGLRTLMLRNNRISC 627
Query: 128 IPKDA 132
I D+
Sbjct: 628 IHNDS 632
Score = 57.8 bits (138), Expect = 9e-09
Identities = 55/170 (32%), Positives = 69/170 (40%), Gaps = 37/170 (21%)
Query: 6 PPRPSLLLVSTRESCLFLLFCLHLGA-ACPQPCRCPDHAGAVAVFCSLRGLQEVPEDIPA 64
P RP L L L LGA ACP C C V C GLQ +P++IP
Sbjct: 13 PVRPELWL-------LLWAAAWRLGASACPALCTCT----GTTVDCHGTGLQAIPKNIPR 61
Query: 65 NTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRL------- 117
NT L+L+ N I+ + F L +LR L L N I A+ F + RL
Sbjct: 62 NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Query: 118 ----------------LDLSYNRIQRIPKDAL-GKLSAK-IRLSHNPLHC 149
LDLS N IQ IP+ A G K ++L N + C
Sbjct: 122 HMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISC 171
Score = 37.0 bits (84), Expect = 0.017
Identities = 28/105 (26%), Positives = 41/105 (39%), Gaps = 23/105 (21%)
Query: 68 LLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDLSYNRIQR 127
LL L+ANKI+ + AFQ L L L L N I+++ TF L
Sbjct: 385 LLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSL---------------- 428
Query: 128 IPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIAC 172
+ + L+ NP C+C L+ L+ +P C
Sbjct: 429 -------RAIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGARC 466
Score = 32.3 bits (72), Expect = 0.42
Identities = 17/40 (42%), Positives = 26/40 (65%)
Query: 69 LKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATF 108
L+LD N+IS + +GAF+ L L L L++N I I ++F
Sbjct: 162 LQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSF 201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,878,770
Number of Sequences: 37866
Number of extensions: 477088
Number of successful extensions: 2244
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 1167
Number of HSP's gapped (non-prelim): 733
length of query: 257
length of database: 18,247,518
effective HSP length: 100
effective length of query: 157
effective length of database: 14,460,918
effective search space: 2270364126
effective search space used: 2270364126
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.