Search of human proteins with 58530842

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58530842 desmoplakin isoform II [Homo sapiens]
         (2272 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58530842 desmoplakin isoform II [Homo sapiens]                    4481   0.0  
gi|58530840 desmoplakin isoform I [Homo sapiens]                     2428   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       964   0.0  
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       964   0.0  
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        964   0.0  
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        964   0.0  
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        964   0.0  
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        964   0.0  
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        964   0.0  
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        964   0.0  
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]               606   e-173
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]             596   e-170
gi|221316624 dystonin isoform 4 [Homo sapiens]                        577   e-164
gi|221316622 dystonin isoform 3 [Homo sapiens]                        577   e-164
gi|221316618 dystonin isoform 2 [Homo sapiens]                        577   e-164
gi|34577047 dystonin isoform 1 [Homo sapiens]                         577   e-164
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             577   e-164
gi|33188445 microfilament and actin filament cross-linker protei...   516   e-145
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   460   e-129
gi|207452735 epiplakin 1 [Homo sapiens]                               382   e-105
gi|156104874 envoplakin [Homo sapiens]                                243   2e-63
gi|45439327 periplakin [Homo sapiens]                                 224   1e-57
gi|33188443 microfilament and actin filament cross-linker protei...   132   5e-30
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   106   2e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   103   3e-21
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   103   3e-21
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   103   3e-21
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   103   3e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   102   3e-21
gi|16262452 cingulin [Homo sapiens]                                    99   5e-20

>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score = 4481 bits (11623), Expect = 0.0
 Identities = 2272/2272 (100%), Positives = 2272/2272 (100%)

Query: 1    MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60
            MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG
Sbjct: 1    MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60

Query: 61   TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120
            TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI
Sbjct: 61   TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120

Query: 121  LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
            LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW
Sbjct: 121  LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 241  DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300
            DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD
Sbjct: 241  DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300

Query: 301  KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360
            KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW
Sbjct: 301  KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360

Query: 361  ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420
            ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE
Sbjct: 361  ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420

Query: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480
            LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD
Sbjct: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480

Query: 481  ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540
            ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL
Sbjct: 481  ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540

Query: 541  YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600
            YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF
Sbjct: 541  YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600

Query: 601  GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660
            GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE
Sbjct: 601  GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660

Query: 661  NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720
            NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA
Sbjct: 661  NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720

Query: 721  EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
            EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT
Sbjct: 721  EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780

Query: 781  EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840
            EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS
Sbjct: 781  EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840

Query: 841  QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900
            QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK
Sbjct: 841  QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900

Query: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960
            WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD
Sbjct: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960

Query: 961  YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
            YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM
Sbjct: 961  YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020

Query: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
            LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE
Sbjct: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080

Query: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
            ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD
Sbjct: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140

Query: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ 1200
            QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ 1200

Query: 1201 ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1260
            ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ
Sbjct: 1201 ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1260

Query: 1261 IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1320
            IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED
Sbjct: 1261 IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1320

Query: 1321 STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ 1380
            STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ
Sbjct: 1321 STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ 1380

Query: 1381 LYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL 1440
            LYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL
Sbjct: 1381 LYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL 1440

Query: 1441 ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP 1500
            ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP
Sbjct: 1441 ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP 1500

Query: 1501 FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 1560
            FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY
Sbjct: 1501 FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 1560

Query: 1561 RSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTV 1620
            RSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTV
Sbjct: 1561 RSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTV 1620

Query: 1621 TELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMK 1680
            TELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMK
Sbjct: 1621 TELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMK 1680

Query: 1681 IGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGY 1740
            IGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGY
Sbjct: 1681 IGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGY 1740

Query: 1741 NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE 1800
            NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE
Sbjct: 1741 NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE 1800

Query: 1801 ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN 1860
            ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN
Sbjct: 1801 ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN 1860

Query: 1861 TLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVL 1920
            TLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVL
Sbjct: 1861 TLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVL 1920

Query: 1921 VDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSD 1980
            VDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSD
Sbjct: 1921 VDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSD 1980

Query: 1981 DVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIER 2040
            DVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIER
Sbjct: 1981 DVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIER 2040

Query: 2041 GIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFE 2100
            GIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFE
Sbjct: 2041 GIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFE 2100

Query: 2101 GVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGR 2160
            GVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGR
Sbjct: 2101 GVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGR 2160

Query: 2161 AAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNM 2220
            AAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNM
Sbjct: 2161 AAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNM 2220

Query: 2221 SSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2272
            SSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
Sbjct: 2221 SSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2272


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 2428 bits (6293), Expect = 0.0
 Identities = 1238/1376 (89%), Positives = 1272/1376 (92%), Gaps = 41/1376 (2%)

Query: 1    MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60
            MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG
Sbjct: 1    MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60

Query: 61   TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120
            TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI
Sbjct: 61   TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120

Query: 121  LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
            LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW
Sbjct: 121  LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 241  DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300
            DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD
Sbjct: 241  DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300

Query: 301  KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360
            KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW
Sbjct: 301  KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360

Query: 361  ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420
            ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE
Sbjct: 361  ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420

Query: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480
            LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD
Sbjct: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480

Query: 481  ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540
            ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL
Sbjct: 481  ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540

Query: 541  YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600
            YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF
Sbjct: 541  YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600

Query: 601  GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660
            GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE
Sbjct: 601  GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660

Query: 661  NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720
            NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA
Sbjct: 661  NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720

Query: 721  EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
            EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT
Sbjct: 721  EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780

Query: 781  EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840
            EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS
Sbjct: 781  EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840

Query: 841  QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900
            QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK
Sbjct: 841  QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900

Query: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960
            WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD
Sbjct: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960

Query: 961  YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
            YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM
Sbjct: 961  YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020

Query: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
            LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE
Sbjct: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080

Query: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
            ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD
Sbjct: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140

Query: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ 1200
            QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK  N   
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200

Query: 1201 ES----KNQCTQVVQERESLLVKIKVLEQDKA--------RLQR----LEDELNRAKSTL 1244
            E     +N+    +   ++ + +I + ++D +        RL R    L+DE+ R   ++
Sbjct: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260

Query: 1245 EAETRVKQRLE--------C------EKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE 1290
               T  ++R E        C      +KQ ++ +L Q   Q S      ++   E  K+ 
Sbjct: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320

Query: 1291 REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
            ++KN    EIERL+AE +  EE  RR       E +++L   R+ Y  EI  L+ +
Sbjct: 1321 QDKN---KEIERLKAEFQ--EEAKRR------WEYENELSKVRNNYDEEIISLKNQ 1365



 Score = 2132 bits (5523), Expect = 0.0
 Identities = 1147/1473 (77%), Positives = 1245/1473 (84%), Gaps = 21/1473 (1%)

Query: 811  LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRI 870
            +K++KN L      L  ++ ++Q+ +   S+ SQ+    +++L +  +  T+ + R+++ 
Sbjct: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQS 1468

Query: 871  DKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQ 930
                   + D  K+I++L+   D      K L D   R   ++      +++    +N+ 
Sbjct: 1469 LDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKL 1528

Query: 931  KNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSG 990
            K    E++  R   E V +       ++KD ++     T    +L  + +++  ++    
Sbjct: 1529 KVQEQELTRLRIDYERVSQ-----ERTVKDQDI-----TRFQNSLKELQLQKQKVEEELN 1578

Query: 991  VILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVL----EEELRLARD 1046
             + + A++   +  +L        R L E    + +L  +  +  ++    E++LR  RD
Sbjct: 1579 RLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638

Query: 1047 ANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKE 1106
                +  + +   + L++  +E    + +L   +E  +QA L  +  ++ ++     + E
Sbjct: 1639 VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698

Query: 1107 LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQ--CEKENLGWQKLESEKAI 1164
               +I RL    E+  +    +E+     + +YD L++ R      +N    +L S+  I
Sbjct: 1699 SKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQI 1758

Query: 1165 KE-KEYEIERLRVLLQEEGTRKRE----YENELAKASNRIQESKNQCTQVVQERESLLVK 1219
               +  E++ L   LQ E    R+    ++ +  +ASNRIQESKNQCTQVVQERESLLVK
Sbjct: 1759 SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVK 1818

Query: 1220 IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1279
            IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI
Sbjct: 1819 IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878

Query: 1280 RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1339
            RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE
Sbjct: 1879 RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1938

Query: 1340 IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1399
            IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK
Sbjct: 1939 IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1998

Query: 1400 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 1459
            KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI
Sbjct: 1999 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058

Query: 1460 IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR 1519
            IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR
Sbjct: 2059 IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR 2118

Query: 1520 ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK 1579
            ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK
Sbjct: 2119 ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK 2178

Query: 1580 KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES 1639
            KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES
Sbjct: 2179 KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES 2238

Query: 1640 GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT 1699
            GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT
Sbjct: 2239 GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT 2298

Query: 1700 GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL 1759
            GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL
Sbjct: 2299 GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL 2358

Query: 1760 IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP 1819
            IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP
Sbjct: 2359 IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP 2418

Query: 1820 NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS 1879
            NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS
Sbjct: 2419 NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS 2478

Query: 1880 VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL 1939
            VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL
Sbjct: 2479 VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL 2538

Query: 1940 VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS 1999
            VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS
Sbjct: 2539 VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS 2598

Query: 2000 VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG 2059
            VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG
Sbjct: 2599 VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG 2658

Query: 2060 GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL 2119
            GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL
Sbjct: 2659 GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL 2718

Query: 2120 PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK 2179
            PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK
Sbjct: 2719 PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK 2778

Query: 2180 TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR 2239
            TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR
Sbjct: 2779 TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR 2838

Query: 2240 SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2272
            SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
Sbjct: 2839 SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2871



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 130/638 (20%), Positives = 260/638 (40%), Gaps = 127/638 (19%)

Query: 813  KIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDK 872
            K   DL LK + +  ++ EL+ A+  +S+   +    D +L K+  + +Q   +   +++
Sbjct: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081

Query: 873  -----QIDFRL--WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
                 ++D +    +L+K   Q++   +        + D KRR+ S+E  +F        
Sbjct: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVED-RFDQQKNDYD 1140

Query: 926  FLNEQKNLHSEISGK---------RDKSEEVQKIAELCANS---IKDYELQLAS----YT 969
             L + +    E  G          ++K  E++++  L        ++YE +LA     Y 
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200

Query: 970  SGLETLLN-----IPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSL 1024
              +  L N     I I +T I+     I  +  D        L R     R L + +  L
Sbjct: 1201 EEMSNLRNKYETEINITKTTIKE----ISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRL 1256

Query: 1025 EDLKLKNTKIEVLEEELRLARDA-NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
             D  L+ T+     EE  L + A  SE   K + L+                   L+++ 
Sbjct: 1257 NDSILQATEQRRRAEENALQQKACGSEIMQKKQHLE-----------------IELKQVM 1299

Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL- 1142
            +Q   D    KQ+L++    I++ N++I RL  E ++E +RR   E+   + +N+YD+  
Sbjct: 1300 QQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEI 1359

Query: 1143 -------------------QKARQCEKENLGWQK-----------------------LES 1160
                               Q   Q E++  G++                         ++
Sbjct: 1360 ISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQT 1419

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN-------RIQESKNQCTQVVQER 1213
             + ++  E +I++ +    E   RK++ E EL + +        R ++S +   + +Q++
Sbjct: 1420 TENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDK 1479

Query: 1214 ESLLVKIK-----------VLEQDKARLQRLEDELNRAKST-------LEAETRVKQRLE 1255
               + ++K            LE + ARLQR++ +L +A S+       L+ + +   RL 
Sbjct: 1480 NKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLR 1539

Query: 1256 CEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER-- 1313
             + +++  +        +R + ++++++ +++K E E N L+        + K++EE   
Sbjct: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELE 1599

Query: 1314 -CRRKLEDS----TRETQSQLETERSRYQREIDKLRQR 1346
              RR L++     T  TQ QLE      +R  D LRQ+
Sbjct: 1600 GMRRSLKEQAIKITNLTQ-QLEQASIVKKRSEDDLRQQ 1636



 Score = 38.9 bits (89), Expect = 0.058
 Identities = 28/102 (27%), Positives = 55/102 (53%), Gaps = 11/102 (10%)

Query: 245  KSAIYQLEEEYENLL---------KASFERM-DHLRQLQNIIQATSREIMWINDCEEEEL 294
            K+   Q+ +E E+LL         KA  +R+ D L + ++ ++A +R    + +CE++++
Sbjct: 1802 KNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-ECEKQQI 1860

Query: 295  LYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQL 336
              D +   T  ++K+EA     S+ E  E+E N L+ E ++L
Sbjct: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERL 1902



 Score = 35.0 bits (79), Expect = 0.84
 Identities = 64/362 (17%), Positives = 138/362 (38%), Gaps = 59/362 (16%)

Query: 100  QLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVP 159
            QLT  +E D    +A      +D+L RE R + +     +  L Q  E +R + + I   
Sbjct: 1379 QLTMQKEEDTSGYRAQ-----IDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQ-- 1431

Query: 160  RVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGV-----DLASV 214
                   K  G    Q     +   + VT        + +  +D  A  +     ++  +
Sbjct: 1432 -----QQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERL 1486

Query: 215  EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQN 274
            +Q I+        + D   +L +++ DL++ ++      E  N LK   + +  LR    
Sbjct: 1487 KQLIDKETNDRKCLEDENARLQRVQYDLQKANSS---ATETINKLKVQEQELTRLR---- 1539

Query: 275  IIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334
                           + E +  + + K+ +I + Q +      Q +  E+ELN+LK+ + 
Sbjct: 1540 --------------IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTAS 1585

Query: 335  QLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKG 394
            +    +    +++E    +L+ Q   I  +T                 ++ +      K 
Sbjct: 1586 EDSCKRKKLEEELEGMRRSLKEQAIKITNLT-----------------QQLEQASIVKKR 1628

Query: 395  LQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPD 454
             +D +R++    +++   HL E+ +  E+ R    E +   + L+ + + + Q   RN  
Sbjct: 1629 SEDDLRQQ----RDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684

Query: 455  YR 456
            ++
Sbjct: 1685 FQ 1686


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3640 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3699

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3700 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3759

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3760 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3819

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3820 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3878

Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938

Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998

Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058

Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118

Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178

Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4179 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4238

Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4239 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4284

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4285 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4344

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4345 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4404

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4405 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4464

Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4465 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4516

Query: 2265 FSSSS 2269
            FSSSS
Sbjct: 4517 FSSSS 4521



 Score =  597 bits (1538), Expect = e-170
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 408  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 467

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 468  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 524

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 525  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 584

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 585  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 645  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 705  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 764

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 765  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 824

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 825  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 884

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 885  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 944

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 945  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 984

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 985  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1034

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1334 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451

Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511

Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571

Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1630

Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1745

Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1797

Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA 1824



 Score =  528 bits (1359), Expect = e-149
 Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)

Query: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304

Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424

Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484

Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544

Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 2605 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2650

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 2651 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2710

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 2711 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2770

Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 2771 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2830

Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 2831 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2890

Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 2891 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2948

Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
            +I+ +++ + I   ++     G  C  G                   +Y +  + +  + 
Sbjct: 2949 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3008

Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
            +  ++  VR                                    A+ LLEAQA TG I+
Sbjct: 3009 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3068

Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
            DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG  +SLFQA+ K LI + 
Sbjct: 3069 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3128

Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
             G+RLL+AQ++TGGI+DP +SHR+P+D+A  RG  +EE S  LS P  D K + DP+T E
Sbjct: 3129 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3188

Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
              TY +L++RC  D+ TGL LLPL EK  + +                 E   E+  +E 
Sbjct: 3189 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3233

Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
            ++K  ++             WE I+        R  L+ +    +  ++  I   +   +
Sbjct: 3234 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3293

Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
              +  R   LS +       L+  V  S  + SGV S   F   +    +V  +S + SV
Sbjct: 3294 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3347

Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
            R L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG 
Sbjct: 3348 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3397

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            ++ P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  + 
Sbjct: 3398 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3457

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
             + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T
Sbjct: 3458 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3517

Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
               ++Y+  + R + +  TGLRLL
Sbjct: 3518 HENLTYRQLLERCVEDPETGLRLL 3541



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2936 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2991

Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2992 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3048

Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3049 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3108

Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3109 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3168

Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3169 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3212

Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3213 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3269

Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3270 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3329

Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3330 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3389

Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3390 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3449

Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3450 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3509

Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3510 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3569

Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3570 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3621

Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3622 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3652

Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3653 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3705

Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3706 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3765

Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3766 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3825

Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3826 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3884

Query: 2211 SKGLPSPYNM 2220
             +GL     M
Sbjct: 3885 FRGLRKQITM 3894



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 2645 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2704

Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 2705 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2764

Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 2765 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2824

Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2825 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2884

Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 2885 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2928

Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 2929 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2980

Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 2981 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3030

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 3031 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3090

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 3091 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3150

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 3151 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3210

Query: 2205 EAASVSSK 2212
              +  +++
Sbjct: 3211 PLSEKAAR 3218



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938

Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998

Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058

Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118

Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178

Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4179 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4234

Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4235 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4291

Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4292 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4351

Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4352 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4396

Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4397 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4443

Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4444 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4503

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
             S        S  ++T  SSS+S +
Sbjct: 4504 GS---FDATGSGFSMTFSSSSYSSS 4525



 Score =  111 bits (278), Expect = 7e-24
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1772

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1773 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889

Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 1890 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 2007 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062

Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
             E + T+   + V D LR +  A
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEA 2085



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2692 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2751

Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2752 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2811

Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2812 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2871

Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
            + +  TGL LL     ++KG    Y  S A
Sbjct: 2872 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2901


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3644 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3703

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3704 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3763

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3764 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3823

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3824 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3882

Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3883 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3942

Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3943 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4002

Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4003 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4062

Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4063 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4122

Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4123 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4182

Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4183 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4242

Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4243 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4288

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4289 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4348

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4349 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4408

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4409 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4468

Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4469 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4520

Query: 2265 FSSSS 2269
            FSSSS
Sbjct: 4521 FSSSS 4525



 Score =  597 bits (1538), Expect = e-170
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 412  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 471

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 472  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 528

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 529  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 588

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 589  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 648

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 649  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 708

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 709  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 768

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 769  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 828

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 829  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 888

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 889  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 948

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 949  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 988

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 989  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1038

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1039 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1098

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1158

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1159 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1218

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1219 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1278

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1279 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1338 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1395

Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1396 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455

Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1515

Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1516 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1575

Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1576 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1634

Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1635 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1694

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1749

Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1801

Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1802 ELAEEAARLRALAEEAKRQRQLAEEDA 1828



 Score =  528 bits (1359), Expect = e-149
 Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)

Query: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308

Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 2309 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2368

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428

Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2488

Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 2489 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2548

Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 2549 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 2609 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2654

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 2655 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2714

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 2715 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2774

Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 2775 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2834

Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 2835 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2894

Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 2895 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2952

Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
            +I+ +++ + I   ++     G  C  G                   +Y +  + +  + 
Sbjct: 2953 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3012

Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
            +  ++  VR                                    A+ LLEAQA TG I+
Sbjct: 3013 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3072

Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
            DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG  +SLFQA+ K LI + 
Sbjct: 3073 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3132

Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
             G+RLL+AQ++TGGI+DP +SHR+P+D+A  RG  +EE S  LS P  D K + DP+T E
Sbjct: 3133 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3192

Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
              TY +L++RC  D+ TGL LLPL EK  + +                 E   E+  +E 
Sbjct: 3193 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3237

Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
            ++K  ++             WE I+        R  L+ +    +  ++  I   +   +
Sbjct: 3238 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3297

Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
              +  R   LS +       L+  V  S  + SGV S   F   +    +V  +S + SV
Sbjct: 3298 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3351

Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
            R L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG 
Sbjct: 3352 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3401

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            ++ P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  + 
Sbjct: 3402 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3461

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
             + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T
Sbjct: 3462 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3521

Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
               ++Y+  + R + +  TGLRLL
Sbjct: 3522 HENLTYRQLLERCVEDPETGLRLL 3545



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2940 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2995

Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2996 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3052

Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3053 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3112

Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3113 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3172

Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3173 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3216

Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3217 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3273

Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3274 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3333

Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3334 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3393

Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3394 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3453

Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3454 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3513

Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3514 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3573

Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3574 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3625

Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3626 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3656

Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3657 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3709

Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3710 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3769

Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3770 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3829

Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3830 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3888

Query: 2211 SKGLPSPYNM 2220
             +GL     M
Sbjct: 3889 FRGLRKQITM 3898



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 2649 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2708

Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 2709 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2768

Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 2769 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2828

Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2829 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2888

Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 2889 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2932

Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 2933 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2984

Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 2985 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3034

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 3035 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3094

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 3095 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3154

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 3155 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3214

Query: 2205 EAASVSSK 2212
              +  +++
Sbjct: 3215 PLSEKAAR 3222



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3883 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3942

Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3943 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4002

Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 4003 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4062

Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4063 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4122

Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4123 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4182

Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4183 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4238

Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4239 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4295

Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4296 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4355

Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4356 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4400

Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4401 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4447

Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4448 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4507

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
             S        S  ++T  SSS+S +
Sbjct: 4508 GS---FDATGSGFSMTFSSSSYSSS 4529



 Score =  111 bits (278), Expect = 7e-24
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1776

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1777 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1833

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893

Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 1894 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 1951 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010

Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 2011 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066

Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
             E + T+   + V D LR +  A
Sbjct: 2067 QELQQTLQQEQSVLDQLRGEAEA 2089



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2696 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2755

Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2756 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2815

Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2816 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2875

Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
            + +  TGL LL     ++KG    Y  S A
Sbjct: 2876 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2905


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3640 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3699

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3700 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3759

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3760 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3819

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3820 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3878

Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938

Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998

Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058

Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118

Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178

Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4179 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4238

Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4239 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4284

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4285 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4344

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4345 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4404

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4405 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4464

Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4465 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4516

Query: 2265 FSSSS 2269
            FSSSS
Sbjct: 4517 FSSSS 4521



 Score =  597 bits (1538), Expect = e-170
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 408  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 467

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 468  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 524

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 525  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 584

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 585  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 645  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 705  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 764

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 765  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 824

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 825  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 884

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 885  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 944

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 945  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 984

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 985  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1034

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1334 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1391

Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451

Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1511

Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1512 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571

Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1630

Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1631 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1745

Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1797

Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1798 ELAEEAARLRALAEEAKRQRQLAEEDA 1824



 Score =  528 bits (1359), Expect = e-149
 Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)

Query: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304

Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424

Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2484

Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544

Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 2545 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 2605 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2650

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 2651 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2710

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 2711 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2770

Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 2771 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2830

Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 2831 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2890

Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 2891 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2948

Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
            +I+ +++ + I   ++     G  C  G                   +Y +  + +  + 
Sbjct: 2949 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3008

Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
            +  ++  VR                                    A+ LLEAQA TG I+
Sbjct: 3009 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3068

Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
            DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG  +SLFQA+ K LI + 
Sbjct: 3069 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3128

Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
             G+RLL+AQ++TGGI+DP +SHR+P+D+A  RG  +EE S  LS P  D K + DP+T E
Sbjct: 3129 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3188

Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
              TY +L++RC  D+ TGL LLPL EK  + +                 E   E+  +E 
Sbjct: 3189 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3233

Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
            ++K  ++             WE I+        R  L+ +    +  ++  I   +   +
Sbjct: 3234 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3293

Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
              +  R   LS +       L+  V  S  + SGV S   F   +    +V  +S + SV
Sbjct: 3294 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3347

Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
            R L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG 
Sbjct: 3348 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3397

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            ++ P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  + 
Sbjct: 3398 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3457

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
             + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T
Sbjct: 3458 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3517

Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
               ++Y+  + R + +  TGLRLL
Sbjct: 3518 HENLTYRQLLERCVEDPETGLRLL 3541



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2936 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2991

Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2992 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3048

Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3049 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3108

Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3109 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3168

Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3169 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3212

Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3213 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3269

Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3270 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3329

Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3330 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3389

Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3390 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3449

Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3450 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3509

Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3510 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3569

Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3570 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3621

Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3622 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3652

Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3653 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3705

Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3706 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3765

Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3766 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3825

Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3826 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3884

Query: 2211 SKGLPSPYNM 2220
             +GL     M
Sbjct: 3885 FRGLRKQITM 3894



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 2645 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2704

Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 2705 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2764

Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 2765 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2824

Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2825 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2884

Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 2885 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2928

Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 2929 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2980

Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 2981 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3030

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 3031 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3090

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 3091 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3150

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 3151 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3210

Query: 2205 EAASVSSK 2212
              +  +++
Sbjct: 3211 PLSEKAAR 3218



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938

Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998

Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058

Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118

Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178

Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4179 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4234

Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4235 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4291

Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4292 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4351

Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4352 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4396

Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4397 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4443

Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4444 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4503

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
             S        S  ++T  SSS+S +
Sbjct: 4504 GS---FDATGSGFSMTFSSSSYSSS 4525



 Score =  111 bits (278), Expect = 7e-24
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1772

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1773 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889

Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 1890 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 2007 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062

Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
             E + T+   + V D LR +  A
Sbjct: 2063 QELQQTLQQEQSVLDQLRGEAEA 2085



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2692 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2751

Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2752 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2811

Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2812 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2871

Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
            + +  TGL LL     ++KG    Y  S A
Sbjct: 2872 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2901


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3608 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3667

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3668 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3727

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3728 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3787

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3788 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3846

Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3847 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3906

Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3907 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3966

Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3967 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4026

Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4027 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4086

Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4087 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4146

Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4147 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4206

Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4207 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4252

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4253 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4312

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4313 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4372

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4373 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4432

Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4433 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4484

Query: 2265 FSSSS 2269
            FSSSS
Sbjct: 4485 FSSSS 4489



 Score =  597 bits (1538), Expect = e-170
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 376  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 435

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 436  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 492

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 493  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 552

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 553  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 612

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 613  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 672

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 673  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 732

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 733  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 792

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 793  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 852

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 853  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 912

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 913  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 952

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 953  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1002

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1003 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1062

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1122

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1123 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1182

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1183 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1242

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1243 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1302 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1359

Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1360 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419

Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1479

Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1480 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1539

Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1540 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1598

Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1599 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1658

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1713

Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1765

Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1766 ELAEEAARLRALAEEAKRQRQLAEEDA 1792



 Score =  528 bits (1359), Expect = e-149
 Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)

Query: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 2213 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272

Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 2273 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2332

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392

Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 2393 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2452

Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 2453 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2512

Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 2513 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 2573 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2618

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 2619 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2678

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 2679 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2738

Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 2739 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2798

Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 2799 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2858

Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 2859 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2916

Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
            +I+ +++ + I   ++     G  C  G                   +Y +  + +  + 
Sbjct: 2917 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 2976

Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
            +  ++  VR                                    A+ LLEAQA TG I+
Sbjct: 2977 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3036

Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
            DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG  +SLFQA+ K LI + 
Sbjct: 3037 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3096

Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
             G+RLL+AQ++TGGI+DP +SHR+P+D+A  RG  +EE S  LS P  D K + DP+T E
Sbjct: 3097 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3156

Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
              TY +L++RC  D+ TGL LLPL EK  + +                 E   E+  +E 
Sbjct: 3157 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3201

Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
            ++K  ++             WE I+        R  L+ +    +  ++  I   +   +
Sbjct: 3202 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3261

Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
              +  R   LS +       L+  V  S  + SGV S   F   +    +V  +S + SV
Sbjct: 3262 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3315

Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
            R L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG 
Sbjct: 3316 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3365

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            ++ P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  + 
Sbjct: 3366 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3425

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
             + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T
Sbjct: 3426 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3485

Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
               ++Y+  + R + +  TGLRLL
Sbjct: 3486 HENLTYRQLLERCVEDPETGLRLL 3509



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2904 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2959

Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2960 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3016

Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3017 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3076

Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3077 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3136

Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3137 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3180

Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3181 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3237

Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3238 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3297

Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3298 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3357

Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3358 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3417

Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3418 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3477

Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3478 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3537

Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3538 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3589

Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3590 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3620

Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3621 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3673

Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3674 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3733

Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3734 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3793

Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3794 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3852

Query: 2211 SKGLPSPYNM 2220
             +GL     M
Sbjct: 3853 FRGLRKQITM 3862



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 2613 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2672

Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 2673 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2732

Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 2733 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2792

Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2793 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2852

Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 2853 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2896

Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 2897 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2948

Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 2949 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 2998

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 2999 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3058

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 3059 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3118

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 3119 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3178

Query: 2205 EAASVSSK 2212
              +  +++
Sbjct: 3179 PLSEKAAR 3186



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3847 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3906

Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3907 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3966

Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3967 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4026

Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4027 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4086

Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4087 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4146

Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4147 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4202

Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4203 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4259

Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4260 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4319

Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4320 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4364

Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4365 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4411

Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4412 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4471

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
             S        S  ++T  SSS+S +
Sbjct: 4472 GS---FDATGSGFSMTFSSSSYSSS 4493



 Score =  111 bits (278), Expect = 7e-24
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1740

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1741 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1797

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857

Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 1858 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 1915 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974

Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 1975 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030

Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
             E + T+   + V D LR +  A
Sbjct: 2031 QELQQTLQQEQSVLDQLRGEAEA 2053



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2660 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2719

Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2720 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2779

Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2780 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2839

Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
            + +  TGL LL     ++KG    Y  S A
Sbjct: 2840 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2869


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3777 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3836

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3837 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3896

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3897 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3956

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3957 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 4015

Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075

Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135

Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195

Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255

Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315

Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4316 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4375

Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4376 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4421

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4422 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4481

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4482 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4541

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4542 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4601

Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4602 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4653

Query: 2265 FSSSS 2269
            FSSSS
Sbjct: 4654 FSSSS 4658



 Score =  597 bits (1538), Expect = e-170
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 545  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 604

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 605  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 661

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 662  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 721

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 722  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 781

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 782  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 841

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 842  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 901

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 902  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 961

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 962  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 1021

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 1022 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1081

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 1082 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1121

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 1122 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1171

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1351

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1352 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1411

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1412 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1471 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1528

Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1529 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588

Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1648

Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1649 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708

Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1767

Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1882

Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1934

Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1935 ELAEEAARLRALAEEAKRQRQLAEEDA 1961



 Score =  528 bits (1359), Expect = e-149
 Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)

Query: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441

Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2501

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561

Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2621

Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 2622 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2681

Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 2682 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 2742 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2787

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 2788 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2847

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 2848 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2907

Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 2908 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2967

Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 2968 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 3027

Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 3028 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 3085

Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
            +I+ +++ + I   ++     G  C  G                   +Y +  + +  + 
Sbjct: 3086 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3145

Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
            +  ++  VR                                    A+ LLEAQA TG I+
Sbjct: 3146 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3205

Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
            DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG  +SLFQA+ K LI + 
Sbjct: 3206 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3265

Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
             G+RLL+AQ++TGGI+DP +SHR+P+D+A  RG  +EE S  LS P  D K + DP+T E
Sbjct: 3266 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3325

Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
              TY +L++RC  D+ TGL LLPL EK  + +                 E   E+  +E 
Sbjct: 3326 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3370

Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
            ++K  ++             WE I+        R  L+ +    +  ++  I   +   +
Sbjct: 3371 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3430

Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
              +  R   LS +       L+  V  S  + SGV S   F   +    +V  +S + SV
Sbjct: 3431 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3484

Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
            R L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG 
Sbjct: 3485 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            ++ P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  + 
Sbjct: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
             + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T
Sbjct: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654

Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
               ++Y+  + R + +  TGLRLL
Sbjct: 3655 HENLTYRQLLERCVEDPETGLRLL 3678



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 3073 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3128

Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 3129 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3185

Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3186 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3245

Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3246 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3305

Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3306 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3349

Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3350 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3406

Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3407 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3466

Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3467 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3526

Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3527 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3586

Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3587 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3646

Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3647 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3706

Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3707 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3758

Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3759 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3789

Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3790 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3842

Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3843 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3902

Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3903 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3962

Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3963 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 4021

Query: 2211 SKGLPSPYNM 2220
             +GL     M
Sbjct: 4022 FRGLRKQITM 4031



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 2782 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2841

Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 2842 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2901

Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 2902 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2961

Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2962 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 3021

Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 3022 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 3065

Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 3066 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 3117

Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 3118 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3167

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 3168 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3227

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 3228 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3287

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 3288 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3347

Query: 2205 EAASVSSK 2212
              +  +++
Sbjct: 3348 PLSEKAAR 3355



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075

Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135

Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195

Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255

Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315

Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4316 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4371

Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4372 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4428

Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4429 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4488

Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4489 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4533

Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4534 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4580

Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4581 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4640

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
             S        S  ++T  SSS+S +
Sbjct: 4641 GS---FDATGSGFSMTFSSSSYSSS 4662



 Score =  111 bits (278), Expect = 7e-24
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1909

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1910 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1966

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026

Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 2027 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 2084 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143

Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 2144 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199

Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
             E + T+   + V D LR +  A
Sbjct: 2200 QELQQTLQQEQSVLDQLRGEAEA 2222



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2829 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2888

Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2889 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2948

Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2949 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 3008

Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
            + +  TGL LL     ++KG    Y  S A
Sbjct: 3009 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 3038


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3618 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3677

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3678 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3737

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3738 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3797

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3798 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3856

Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916

Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976

Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036

Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096

Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156

Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4157 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4216

Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4217 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4262

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4263 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4322

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4323 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4382

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4383 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4442

Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4443 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4494

Query: 2265 FSSSS 2269
            FSSSS
Sbjct: 4495 FSSSS 4499



 Score =  597 bits (1538), Expect = e-170
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 386  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 445

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 446  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 502

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 503  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 562

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 563  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 622

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 623  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 682

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 683  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 742

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 743  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 802

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 803  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 862

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 863  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 922

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 923  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 962

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 963  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1012

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1192

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1193 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1252

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1253 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1312 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1369

Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1370 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429

Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489

Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1490 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549

Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1608

Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1723

Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1775

Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1776 ELAEEAARLRALAEEAKRQRQLAEEDA 1802



 Score =  528 bits (1359), Expect = e-149
 Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)

Query: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282

Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2342

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402

Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2462

Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 2463 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2522

Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 2523 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 2583 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2628

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 2629 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2688

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 2689 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2748

Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 2749 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2808

Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 2809 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2868

Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 2869 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2926

Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
            +I+ +++ + I   ++     G  C  G                   +Y +  + +  + 
Sbjct: 2927 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 2986

Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
            +  ++  VR                                    A+ LLEAQA TG I+
Sbjct: 2987 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3046

Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
            DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG  +SLFQA+ K LI + 
Sbjct: 3047 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3106

Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
             G+RLL+AQ++TGGI+DP +SHR+P+D+A  RG  +EE S  LS P  D K + DP+T E
Sbjct: 3107 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3166

Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
              TY +L++RC  D+ TGL LLPL EK  + +                 E   E+  +E 
Sbjct: 3167 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3211

Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
            ++K  ++             WE I+        R  L+ +    +  ++  I   +   +
Sbjct: 3212 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3271

Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
              +  R   LS +       L+  V  S  + SGV S   F   +    +V  +S + SV
Sbjct: 3272 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3325

Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
            R L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG 
Sbjct: 3326 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3375

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            ++ P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  + 
Sbjct: 3376 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3435

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
             + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T
Sbjct: 3436 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3495

Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
               ++Y+  + R + +  TGLRLL
Sbjct: 3496 HENLTYRQLLERCVEDPETGLRLL 3519



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2914 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2969

Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2970 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3026

Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3027 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3086

Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3087 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3146

Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3147 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3190

Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3191 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3247

Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3248 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3307

Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3308 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3367

Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3368 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3427

Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3428 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3487

Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3488 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3547

Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3548 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3599

Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3600 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3630

Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3631 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3683

Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3684 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3743

Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3744 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3803

Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3804 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3862

Query: 2211 SKGLPSPYNM 2220
             +GL     M
Sbjct: 3863 FRGLRKQITM 3872



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 2623 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2682

Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 2683 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2742

Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 2743 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2802

Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2803 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2862

Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 2863 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2906

Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 2907 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2958

Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 2959 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3008

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 3009 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3068

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 3069 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3128

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 3129 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3188

Query: 2205 EAASVSSK 2212
              +  +++
Sbjct: 3189 PLSEKAAR 3196



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916

Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976

Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036

Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096

Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156

Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4157 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4212

Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4213 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4269

Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4270 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4329

Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4330 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4374

Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4375 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4421

Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4422 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4481

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
             S        S  ++T  SSS+S +
Sbjct: 4482 GS---FDATGSGFSMTFSSSSYSSS 4503



 Score =  111 bits (278), Expect = 7e-24
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1750

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1751 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1807

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867

Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 1868 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984

Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 1985 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040

Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
             E + T+   + V D LR +  A
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEA 2063



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2670 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2729

Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2730 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2789

Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2790 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2849

Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
            + +  TGL LL     ++KG    Y  S A
Sbjct: 2850 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2879


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3626 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3685

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3686 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3745

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3746 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3805

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3806 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3864

Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3865 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3924

Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3925 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3984

Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3985 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4044

Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4045 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4104

Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4105 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4164

Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4165 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4224

Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4225 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4270

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4271 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4330

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4331 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4390

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4391 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4450

Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4451 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4502

Query: 2265 FSSSS 2269
            FSSSS
Sbjct: 4503 FSSSS 4507



 Score =  597 bits (1538), Expect = e-170
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 394  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 453

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 454  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 510

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 511  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 570

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 571  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 630

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 631  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 690

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 691  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 750

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 751  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 810

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 811  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 870

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 871  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 930

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 931  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 970

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 971  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1020

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1021 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1080

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1140

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1141 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1200

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1201 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1260

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1261 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1320 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1377

Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1378 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437

Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1497

Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1498 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1557

Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1558 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1616

Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1617 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1676

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1731

Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1783

Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1784 ELAEEAARLRALAEEAKRQRQLAEEDA 1810



 Score =  528 bits (1359), Expect = e-149
 Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)

Query: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 2231 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290

Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 2291 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2350

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2410

Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 2411 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2470

Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 2471 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2530

Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 2531 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 2591 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2636

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 2637 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2696

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 2697 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2756

Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 2757 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2816

Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 2817 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2876

Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 2877 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2934

Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
            +I+ +++ + I   ++     G  C  G                   +Y +  + +  + 
Sbjct: 2935 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 2994

Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
            +  ++  VR                                    A+ LLEAQA TG I+
Sbjct: 2995 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3054

Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
            DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG  +SLFQA+ K LI + 
Sbjct: 3055 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3114

Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
             G+RLL+AQ++TGGI+DP +SHR+P+D+A  RG  +EE S  LS P  D K + DP+T E
Sbjct: 3115 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3174

Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
              TY +L++RC  D+ TGL LLPL EK  + +                 E   E+  +E 
Sbjct: 3175 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3219

Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
            ++K  ++             WE I+        R  L+ +    +  ++  I   +   +
Sbjct: 3220 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3279

Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
              +  R   LS +       L+  V  S  + SGV S   F   +    +V  +S + SV
Sbjct: 3280 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3333

Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
            R L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG 
Sbjct: 3334 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3383

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            ++ P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  + 
Sbjct: 3384 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3443

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
             + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T
Sbjct: 3444 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3503

Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
               ++Y+  + R + +  TGLRLL
Sbjct: 3504 HENLTYRQLLERCVEDPETGLRLL 3527



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2922 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2977

Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2978 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3034

Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3035 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3094

Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3095 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3154

Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3155 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3198

Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3199 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3255

Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3256 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3315

Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3316 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3375

Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3376 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3435

Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3436 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3495

Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3496 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3555

Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3556 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3607

Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3608 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3638

Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3639 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3691

Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3692 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3751

Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3752 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3811

Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3812 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3870

Query: 2211 SKGLPSPYNM 2220
             +GL     M
Sbjct: 3871 FRGLRKQITM 3880



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 2631 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2690

Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 2691 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2750

Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 2751 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2810

Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2811 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2870

Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 2871 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2914

Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 2915 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2966

Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 2967 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3016

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 3017 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3076

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 3077 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3136

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 3137 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3196

Query: 2205 EAASVSSK 2212
              +  +++
Sbjct: 3197 PLSEKAAR 3204



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3865 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3924

Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3925 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3984

Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3985 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4044

Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4045 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4104

Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4105 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4164

Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4165 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4220

Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4221 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4277

Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4278 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4337

Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4338 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4382

Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4383 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4429

Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4430 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4489

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
             S        S  ++T  SSS+S +
Sbjct: 4490 GS---FDATGSGFSMTFSSSSYSSS 4511



 Score =  111 bits (278), Expect = 7e-24
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1758

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1759 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1815

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1875

Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 1876 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 1933 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992

Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 1993 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048

Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
             E + T+   + V D LR +  A
Sbjct: 2049 QELQQTLQQEQSVLDQLRGEAEA 2071



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2678 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2737

Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2738 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2797

Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2798 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2857

Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
            + +  TGL LL     ++KG    Y  S A
Sbjct: 2858 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2887


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3667 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3726

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3727 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3786

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3787 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3846

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3847 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3905

Query: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965

Query: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025

Query: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085

Query: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145

Query: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205

Query: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4206 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4265

Query: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4266 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4311

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4312 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4371

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4372 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4431

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4432 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4491

Query: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4492 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4543

Query: 2265 FSSSS 2269
            FSSSS
Sbjct: 4544 FSSSS 4548



 Score =  597 bits (1538), Expect = e-170
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 435  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 494

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 495  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 551

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 552  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 611

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 612  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 671

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 672  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 731

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 732  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 791

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 792  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 851

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 852  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 911

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 912  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 971

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 972  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1011

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 1012 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1061

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1122 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1181

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1182 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1241

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1242 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1301

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1302 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1361 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1418

Query: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1419 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478

Query: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1479 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1538

Query: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1539 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1598

Query: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1657

Query: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1658 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1717

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1772

Query: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1824

Query: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1825 ELAEEAARLRALAEEAKRQRQLAEEDA 1851



 Score =  528 bits (1359), Expect = e-149
 Identities = 395/1344 (29%), Positives = 672/1344 (50%), Gaps = 183/1344 (13%)

Query: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331

Query: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 2332 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2391

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451

Query: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2511

Query: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 2512 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2571

Query: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 2572 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 2632 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2677

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 2678 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2737

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 2738 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2797

Query: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 2798 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2857

Query: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 2858 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2917

Query: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 2918 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2975

Query: 1641 QISYDEVGERIKDFLQ-----GSSCIAG-------------------IYNETTKQKLGIY 1676
            +I+ +++ + I   ++     G  C  G                   +Y +  + +  + 
Sbjct: 2976 RITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3035

Query: 1677 EAMKIGLVR---------------------------------PGTALELLEAQAATGFIV 1703
            +  ++  VR                                    A+ LLEAQA TG I+
Sbjct: 3036 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3095

Query: 1704 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 1763
            DP ++ RL V+EA + GLVG EF EKLLSAE+AVTGY DP TG  +SLFQA+ K LI + 
Sbjct: 3096 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3155

Query: 1764 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEE 1823
             G+RLL+AQ++TGGI+DP +SHR+P+D+A  RG  +EE S  LS P  D K + DP+T E
Sbjct: 3156 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3215

Query: 1824 NLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEA 1883
              TY +L++RC  D+ TGL LLPL EK  + +                 E   E+  +E 
Sbjct: 3216 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR---------------QEELYSELQARET 3260

Query: 1884 YKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRK 1943
            ++K  ++             WE I+        R  L+ +    +  ++  I   +   +
Sbjct: 3261 FEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVE 3320

Query: 1944 FFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSV 2000
              +  R   LS +       L+  V  S  + SGV S   F   +    +V  +S + SV
Sbjct: 3321 EVETLRQERLSFS------GLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV 3374

Query: 2001 RNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGG 2060
            R L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG 
Sbjct: 3375 RTL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3424

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            ++ P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  + 
Sbjct: 3425 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3484

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKT 2180
             + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T
Sbjct: 3485 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3544

Query: 2181 KLKISYKDAINRSMVEDITGLRLL 2204
               ++Y+  + R + +  TGLRLL
Sbjct: 3545 HENLTYRQLLERCVEDPETGLRLL 3568



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2963 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3018

Query: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 3019 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3075

Query: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3076 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3135

Query: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3136 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3195

Query: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3196 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3239

Query: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3240 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3296

Query: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3297 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3356

Query: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3357 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3416

Query: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3417 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3476

Query: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3477 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3536

Query: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3537 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3596

Query: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3597 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3648

Query: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3649 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3679

Query: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3680 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3732

Query: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3733 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3792

Query: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3793 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3852

Query: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3853 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3911

Query: 2211 SKGLPSPYNM 2220
             +GL     M
Sbjct: 3912 FRGLRKQITM 3921



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 2672 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2731

Query: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 2732 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2791

Query: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 2792 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2851

Query: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 2852 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2911

Query: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 2912 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2955

Query: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 2956 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 3007

Query: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 3008 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3057

Query: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 3058 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3117

Query: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 3118 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3177

Query: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 3178 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3237

Query: 2205 EAASVSSK 2212
              +  +++
Sbjct: 3238 PLSEKAAR 3245



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965

Query: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025

Query: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085

Query: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145

Query: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205

Query: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4206 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4261

Query: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4262 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4318

Query: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4319 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4378

Query: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4379 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4423

Query: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4424 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4470

Query: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4471 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4530

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013
             S        S  ++T  SSS+S +
Sbjct: 4531 GS---FDATGSGFSMTFSSSSYSSS 4552



 Score =  111 bits (278), Expect = 7e-24
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1799

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1800 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1856

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916

Query: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 1917 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033

Query: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 2034 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089

Query: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378
             E + T+   + V D LR +  A
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEA 2112



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2719 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2778

Query: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2779 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2838

Query: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2839 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2898

Query: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223
            + +  TGL LL     ++KG    Y  S A
Sbjct: 2899 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2928


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score =  606 bits (1562), Expect = e-173
 Identities = 368/1259 (29%), Positives = 657/1259 (52%), Gaps = 139/1259 (11%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085

Query: 1008 TRSGDYYRFLSEMLKSLEDLKLK------------------------NTKI--------- 1034
            T    Y +F  + LK LE+ ++K                        N+K+         
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELER 1145

Query: 1035 ---------EVLEEELRLARDANSENCNKNK--FLDQNLQKYQA--ECSQFKAKLASLEE 1081
                       +EEEL   R+A      K +    D +LQK +A  E  Q++ +L ++  
Sbjct: 1146 MVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVR 1205

Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---------- 1131
             K  AE + +  +Q   +   +   + E +     ++E+    R+++ED           
Sbjct: 1206 EKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLND 1265

Query: 1132 FDQQKND-YDQLQKARQCEKE----------NLGWQKLESEKAIKEKE-YEIERLRVLLQ 1179
             +QQKN   ++L++ R  E+E          +L +QK  +EK +KEK+  E+E  R + +
Sbjct: 1266 LEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITE 1325

Query: 1180 EEGTRKREYENEL----------AKASNRIQE--SKNQCTQVVQERESLLVKIKVLEQDK 1227
             + T +   EN L           +A   +Q+   K +  ++ Q+ + L    +  EQD 
Sbjct: 1326 IQYTCR---ENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM 1382

Query: 1228 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1287
              L    + L   K++ E + R+   L+ +  +  N L   K +  RK++A +    +  
Sbjct: 1383 RELTYELNALQLEKTSSEEKARL---LKDKLDETNNTLRCLKLELERKDQAEKGYSQQLR 1439

Query: 1288 KSEREKNSLRSEIERLQAE---IKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1343
            +  R+ N    + E    E   +K+I+   + +LE         L  E+ + QRE+D++
Sbjct: 1440 ELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELE--------SLNHEKGKLQREVDRI 1490



 Score =  377 bits (969), Expect = e-104
 Identities = 218/619 (35%), Positives = 346/619 (55%), Gaps = 50/619 (8%)

Query: 1603 SVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 1662
            SV+     FQG+R  VT  +LV++ +L   T+ +L  G  + +EV + +  FL  ++ IA
Sbjct: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIA 2140

Query: 1663 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 1722
            G+Y E+TK+K+    A +  ++    AL  LEAQAATGFI+DP+S     VE+A  +G+V
Sbjct: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200

Query: 1723 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 1782
              EF+ +LL AE+A  GY+   +   +S+FQAM   ++++  G  +LEAQIA+GG+IDP 
Sbjct: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258

Query: 1783 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 1842
               R+P +IA ++G  N  + + L +PS +T+ F +PN ++ L Y +L   C+ D E+  
Sbjct: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318

Query: 1843 CLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQEC 1902
             L P  E+      S  N  +  R+ +VD +T  E++V EA+++ LI+   + EL  Q+ 
Sbjct: 2319 FLFPFGERN----ISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY 2374

Query: 1903 EWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 1962
            +W+E     S G +  +L D KTG  ++I +AI++G +D+    +Y+ G ++LT+ AD  
Sbjct: 2375 QWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-- 2432

Query: 1963 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2022
                                         S +S +   ++L              SP+A 
Sbjct: 2433 -----------------------------SLLSRLVPKKDL-------------HSPVAG 2450

Query: 2023 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2082
             + T + E+IS+ +   R +VD IT  R LEAQ  TGGII P TG+K  + +A+ +G++D
Sbjct: 2451 YWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVD 2510

Query: 2083 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2142
            +  A +L+  +    G       K MS  EAV    +  E G R LEFQYLTGGL++P+V
Sbjct: 2511 EGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQV 2570

Query: 2143 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2202
            H R+S EEA++ G ID   A +L+D  SY + + CP+TK K++YK+A+ ++  +  TGL+
Sbjct: 2571 HSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLK 2630

Query: 2203 LLEAASVSSKGLPSPYNMS 2221
            LLE +     G+ S Y  S
Sbjct: 2631 LLEVSEPLMTGISSLYYSS 2649



 Score =  272 bits (696), Expect = 2e-72
 Identities = 324/1404 (23%), Positives = 588/1404 (41%), Gaps = 264/1404 (18%)

Query: 647  QDVNHNKVIETNRENDKQETWMLMELQKIRR--QIEHCEGRMTLKNLPLADQGSSHHITV 704
            +D+   K +   +  +KQ+    +EL+  R+  +I++      L   P+    S   +T 
Sbjct: 1296 KDLAFQKQVAEKQLKEKQK----IELEARRKITEIQYTCRENALPVCPITQATSCRAVTG 1351

Query: 705  KINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYL 764
               E     +D Q   E+  Q+ ++ A  R +E+          + +    +N +     
Sbjct: 1352 LQQE-----HDKQKAEELKQQVDELTAANRKAEQ---------DMRELTYELNALQLEKT 1397

Query: 765  NSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSL 824
            +S    R L   + +T + L+  +  L  ++         + Y   L+++   LN     
Sbjct: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQA------EKGYSQQLRELGRQLNQTTGK 1451

Query: 825  LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQ 884
                  E    ++I      +    + + GK   +V ++T      +K I      L  Q
Sbjct: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQH----LNSQ 1507

Query: 885  IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS 944
            I   R+ ++      + L   +R+ D L+         +++ +  +K  + +I    ++ 
Sbjct: 1508 IHSFRDEKE-----LERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEEL 1562

Query: 945  EEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYI 1004
            E+  + AE+    +++   Q        ET L +      IQ+ S  I+ E   +  R  
Sbjct: 1563 EKSNECAEMLKQKVEELTRQ------NNETKLMMQ----RIQAESENIVLEKQTIQQR-C 1611

Query: 1005 ELLTRSGDYYRFLSEMLKSLEDLKLKNTK--------IEVLEEELRLARDANSE---NCN 1053
            E L    D ++   + L+S  +   K TK        I+ LEE+L  +++  SE    C+
Sbjct: 1612 EALKIQADGFK---DQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCD 1668

Query: 1054 KNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
            +   + QN +K   E     A+L + +E KR+ E       Q +     Q++ELN ++ +
Sbjct: 1669 QQNIIIQNTKK---EVRNLNAELNASKEEKRRGE-------QKVQLQQAQVQELNNRLKK 1718

Query: 1114 LTYE-----IEDEKRRRKSV-----EDRFDQQKNDY----DQLQKARQCEKENLGWQKLE 1159
            +  E     IE++   RK V       +F Q   ++    ++L +++   + ++   +L+
Sbjct: 1719 VQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLD 1778

Query: 1160 -----------------SEKAIKEKEYEIERLRVLLQE-------EGTRKREYENELAKA 1195
                              E  IKE E ++++ R  +Q+          + ++ E+EL   
Sbjct: 1779 FVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQ 1838

Query: 1196 SNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR------LEDELNRAKSTLEAETR 1249
               ++  K +  Q ++E E  LV ++   Q K+  +        E  +   + + E  +R
Sbjct: 1839 KREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSR 1898

Query: 1250 VKQRLECEKQQIQNDLNQW---------KTQYSRKEEAIRKIES-------EREKSEREK 1293
                L    +   + L +W         K Q+   E+  ++++        E+EKS++  
Sbjct: 1899 NTGHLHPTPR---SPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCY 1955

Query: 1294 NSLRSE--------------IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1339
            +   S+              I RL +EI++I ++         R   +  E E  +    
Sbjct: 1956 SEYFSQTSTELQITFDETNPITRL-SEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTP 2014

Query: 1340 IDKLRQRPYGSHRETQT----------ECEW----------------------------- 1360
            ++  + + Y  H E  T            EW                             
Sbjct: 2015 LEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNF 2074

Query: 1361 ------TVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLR 1414
                  +V   +  F GLR  VTA QL E +L+D  T+++L  G K+VEEV   +  FL 
Sbjct: 2075 DGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLT 2134

Query: 1415 GAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSA 1473
             A SIAG    S KEK S   A  + +I     +  LEAQAATG IIDP   +  +V+ A
Sbjct: 2135 KATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDA 2194

Query: 1474 IARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASG 1533
            + + ++D + R ++  AEKA  G+   +S KT+SV +A++  ++DR+ G  +LEAQIASG
Sbjct: 2195 VLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASG 2252

Query: 1534 GVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVD------------------ 1575
            GV+DPV  + +P ++AL +GL++  + + L++P  + + F +                  
Sbjct: 2253 GVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVF 2312

Query: 1576 ---------PVTKKKVSYVQLKERCRI---EPHTG------------------LLLLSVQ 1605
                     P  ++ +S + +K+  RI   +  TG                   L LS Q
Sbjct: 2313 DVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQ 2372

Query: 1606 ----KRSMSFQGIRQP------------VTVTELVDSGILRPSTVNELESGQISYDEVGE 1649
                K +M F+                   + E ++ G +  + V + + G I+  E+ +
Sbjct: 2373 QYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD 2432

Query: 1650 RIKDFLQGS----SCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDP 1705
             +   L       S +AG +   + +++ + +A +  LV   TAL  LEAQ +TG I+DP
Sbjct: 2433 SLLSRLVPKKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDP 2492

Query: 1706 VSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 1765
            ++  +  V EA  RGLV   F ++L   E  +TG   P T  ++S+ +A+N  +I K  G
Sbjct: 2493 LTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMG 2552

Query: 1766 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENL 1825
            IR LE Q  TGG+I+P+   RL ++ A + G  +  ++  L D     +    P T+  L
Sbjct: 2553 IRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKL 2612

Query: 1826 TYLQLKERCIKDEETGLCLLPLKE 1849
            TY +  E+   D  TGL LL + E
Sbjct: 2613 TYKEALEKADFDFHTGLKLLEVSE 2636



 Score =  124 bits (311), Expect = 1e-27
 Identities = 93/289 (32%), Positives = 145/289 (50%), Gaps = 12/289 (4%)

Query: 1324 ETQSQLETERSRYQ-REIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLY 1382
            E    LE    +YQ +E        + SH  T T+     + ++ +  G   K    + Y
Sbjct: 2362 EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKK-Y 2420

Query: 1383 ECQLIDKTTL-DKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 1441
            +  LI  T L D LL      +++ S +      AG    AS    E+ S+++A R+ L+
Sbjct: 2421 QEGLITLTELADSLLSRLVPKKDLHSPV------AGYWLTASG---ERISVLKASRRNLV 2471

Query: 1442 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 1501
               + +  LEAQ +TGGIIDP   +K  V  A+ R L+D    QQ+   E  ITG   P 
Sbjct: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531

Query: 1502 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 1561
            + K +SV EA+  N+I++E G+R LE Q  +GG+++P     L  + AL  G+ID  +  
Sbjct: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591

Query: 1562 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMS 1610
             L D +   +N + P TK+K++Y +  E+   + HTGL LL V +  M+
Sbjct: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 124/635 (19%), Positives = 259/635 (40%), Gaps = 112/635 (17%)

Query: 909  QDSLESMKFGDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
            +DS ES  F  S+     + +N  K  + E+    ++ E+ + +  L  + +++  L+L 
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 967  SYTSGLETLLNIPIKRTMI-QSPSGVILQEAADVHARYI--ELLTRSGDYYRFLSEMLKS 1023
            +    L   +  P++R  + +S   +  QE        +  +L T +     F S+   S
Sbjct: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814

Query: 1024 LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
                 L++ ++ V+ + +      +S   +K K ++  L+  QA  ++   KL   +  +
Sbjct: 815  SSVPTLRS-ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA--AEALVKLYETKLCE 871

Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR-----------F 1132
             +A +  K+  +NL     Q +   ++  ++ + +EDE ++ K++ D            F
Sbjct: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF 931

Query: 1133 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL---LQEEGTRKREYE 1189
            D  K   DQL +  Q     +  +  + E   K  +Y  +    L   +Q+  T +R+ +
Sbjct: 932  DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991

Query: 1190 NELAKASNRIQESKNQCTQVVQERESLLVKI----KVLEQDKARLQRLEDELNRAKSTLE 1245
                + S  +    NQ   +V E E    K+    K  EQ  A ++  E +    ++ ++
Sbjct: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051

Query: 1246 AETRV---KQRLECEKQQIQNDLNQWKTQYSR-------------------KEEAIRKIE 1283
            ++ +    ++R++     I  +    +T+Y+                    +EE I++ +
Sbjct: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCK 1111

Query: 1284 S-----------EREKSEREKNSLR----SEIERLQAEIK----RIEE---RCRRKLEDS 1321
                        +R+K+   +NS      SE+ER+ AE+K    R+EE   + R   E+ 
Sbjct: 1112 ETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENE 1171

Query: 1322 TRETQSQLE----------TERSRYQREIDKLRQRPYGSHRETQTECEWTVD-------- 1363
             R+ Q  +E          +E  +Y+RE++ + +    + RE +   + T++        
Sbjct: 1172 LRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAV 1231

Query: 1364 ----------------TSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE--- 1404
                            T + + D L++K  ++   E Q   K  L + L+ K+  EE   
Sbjct: 1232 EENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQ---KNKLMEELRRKRDNEEELL 1288

Query: 1405 -VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRK 1438
             +  +++  L     +A      K+K  L EA+RK
Sbjct: 1289 KLIKQMEKDLAFQKQVAEKQLKEKQKIEL-EARRK 1322



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 58/248 (23%), Positives = 111/248 (44%), Gaps = 48/248 (19%)

Query: 216  QHINSHRGIHNSIGDYRWQLDKIKADLREKSAIY-QLEEEYENLL---KASFERMDHLRQ 271
            QH+NS   IH S  D + +L++++   R+   +  Q E+ +E LL   KA  E  D +++
Sbjct: 1502 QHLNSQ--IH-SFRDEK-ELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQR 1557

Query: 272  LQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQ 331
            L   ++ +       N+C E             + QK E  + + ++ ++    + +++ 
Sbjct: 1558 LNEELEKS-------NECAEM------------LKQKVEELTRQNNETKLM---MQRIQA 1595

Query: 332  ESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFE-EAQSTEA 390
            ES+ +VL +     + EA    L+ Q        +  + HL +     Q F+ + +  E 
Sbjct: 1596 ESENIVLEKQTIQQRCEA----LKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEE 1651

Query: 391  YLKGLQDSIRK-KYPCDK-NMPLQHLLEQIKELEKEREKILEYKR-----------QVQN 437
             L   Q+ + + K  CD+ N+ +Q+  ++++ L  E     E KR           QVQ 
Sbjct: 1652 DLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQE 1711

Query: 438  LVNKSKKI 445
            L N+ KK+
Sbjct: 1712 LNNRLKKV 1719


>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score =  596 bits (1537), Expect = e-170
 Identities = 394/1408 (27%), Positives = 706/1408 (50%), Gaps = 116/1408 (8%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085

Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLEEELRLARDA--------NSENCNKNKF 1057
            T    Y +F  + LK L  E+  L+  K E +E+   L +          ++E   K  F
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145

Query: 1058 LDQNLQKYQAECSQFKAKLA-SLEELKR-QAELDGKSAKQNLDKCYGQIKELNEKITRLT 1115
              Q +     E S  K +L+ +L+ ++   A+   K   +  ++   Q+K L E    L 
Sbjct: 1146 SKQKIS--SEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLF 1203

Query: 1116 YEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLR 1175
             E   + +  ++  D   ++K     L K      +    + L   +A+         LR
Sbjct: 1204 SESLKQLQESQTSGDVKVEEK-----LDKVIAGTIDQTTGEVLSVFQAV---------LR 1249

Query: 1176 VLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLED 1235
             L+  + T  R  E +L   S  I     +C  +   +   L+  ++L Q K        
Sbjct: 1250 GLIDYD-TGIRLLETQL-MISGLISPELRKCFDLKDAKSHGLIDEQILCQLK-------- 1299

Query: 1236 ELNRAKSTLEAETRVK-QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKN 1294
            EL++AK  + A +      L+   Q +  +    K            I +  E+   +K 
Sbjct: 1300 ELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKA 1359

Query: 1295 SLRSEI-ERLQAEIKRIEERCRRKLEDSTRETQSQLE-TERSRYQREIDK--LRQRPYGS 1350
              ++ +   L +++   +  C+  ++  T E  S ++  +RS  Q       L  RP   
Sbjct: 1360 FQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEG 1419

Query: 1351 HRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ 1410
             R T  +C   +   +   +GL  + T  +L   QL+                       
Sbjct: 1420 GRIT-LKCGRNISILRAAHEGLIDRETMFRLLSAQLL----------------------- 1455

Query: 1411 PFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTV 1470
                 +G +  +++   ++ ++ EA R+ +I  ++   +L  Q  TGGII  +  ++LTV
Sbjct: 1456 -----SGGLINSNSG--QRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508

Query: 1471 DSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQI 1530
            D A+  DLI       +  A++   G   P SG+    S ++++ LI  E   ++L  + 
Sbjct: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQ 1568

Query: 1531 ASGGVVDPVNSVFLPKDVALARGLIDRD 1558
                +  P +S  +  D A   G+ID +
Sbjct: 1569 KIAALYIPESSQVIGLDAAKQLGIIDNN 1596



 Score =  150 bits (378), Expect = 2e-35
 Identities = 188/946 (19%), Positives = 400/946 (42%), Gaps = 83/946 (8%)

Query: 909  QDSLESMKFGDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
            +DS ES  F  S+     + +N  K  + E+    ++ E+ + +  L  + +++  L+L 
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 967  SYTSGLETLLNIPIKRTMI-QSPSGVILQEAADVHARYI--ELLTRSGDYYRFLSEMLKS 1023
            +    L   +  P++R  + +S   +  QE        +  +L T +     F S+   S
Sbjct: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814

Query: 1024 LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
                 L++ ++ V+ + +      +S   +K K ++  L+  QA  ++   KL   +  +
Sbjct: 815  SSVPTLRS-ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQA--AEALVKLYETKLCE 871

Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR-----------F 1132
             +A +  K+  +NL     Q +   ++  ++ + +EDE ++ K++ D            F
Sbjct: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF 931

Query: 1133 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL---LQEEGTRKREYE 1189
            D  K   DQL +  Q     +  +  + E   K  +Y  +    L   +Q+  T +R+ +
Sbjct: 932  DWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991

Query: 1190 NELAKASNRIQESKNQCTQVVQERESLLVKI----KVLEQDKARLQRLEDELNRAKSTLE 1245
                + S  +    NQ   +V E E    K+    K  EQ  A ++  E +    ++ ++
Sbjct: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1051

Query: 1246 AETRV---KQRLECEKQQIQNDLNQWKTQYSR-----------KEEAIRKIESEREKSER 1291
            ++ +    ++R++     I  +    +T+Y+              ++++++E E +  E 
Sbjct: 1052 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1111

Query: 1292 EKNSLRSEIERLQAEIKRIE------ERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1345
            EK     + + LQ  +  I       E+  +      + +  ++ T++ +    +  + Q
Sbjct: 1112 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI-Q 1170

Query: 1346 RPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVE-E 1404
                 H +  T+ E          + L K+V  +Q     L+   +L +L + + S + +
Sbjct: 1171 LFLAKHGDKMTDEER---------NELEKQVKTLQ-ESYNLLFSESLKQLQESQTSGDVK 1220

Query: 1405 VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHR 1464
            V  ++   + G         +  E  S+ +A  + LI  ++ + LLE Q    G+I P  
Sbjct: 1221 VEEKLDKVIAGT-----IDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPEL 1275

Query: 1465 NEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMR 1524
             +   +  A +  LID     Q+    KA        S  T+ V +A+ +++I     ++
Sbjct: 1276 RKCFDLKDAKSHGLIDEQILCQLKELSKA-KEIISAASPTTIPVLDALAQSMITESMAIK 1334

Query: 1525 LLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSY 1584
            +LE  +++G +V P     L    A  + L+   L+  + + ++  K+ +DP T +KVS 
Sbjct: 1335 VLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSL 1394

Query: 1585 VQLKERCRIEPHTGLLLLSVQKRSMSFQGIR--QPVTVTELVDSGILRPSTVNELESGQI 1642
            + + +R  ++ +TG+ LL V+ +      ++  + +++      G++   T+  L S Q+
Sbjct: 1395 IDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQL 1454

Query: 1643 SYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFI 1702
                        L G     G+ N  + Q++ + EA++ G++   TA  +L  Q  TG I
Sbjct: 1455 ------------LSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGI 1497

Query: 1703 VDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEK 1762
            +      RL V+EA +  L+       +L A+R   G   P +G I     ++ +ELI  
Sbjct: 1498 IQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITN 1557

Query: 1763 GHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808
                ++L  +     +  P+ S  + +D A + G  +   + IL +
Sbjct: 1558 ELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603



 Score = 95.1 bits (235), Expect = 7e-19
 Identities = 191/968 (19%), Positives = 390/968 (40%), Gaps = 144/968 (14%)

Query: 1117 EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRV 1176
            E+ + + R ++ EDR  +Q             E+++L     ES   I E+E   + L  
Sbjct: 745  EVRNIRLRLENCEDRLIRQIRT--------PLERDDLH----ESVFRITEQEKLKKELER 792

Query: 1177 LLQEEGTRKREYEN--ELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLE 1234
            L  + GT   + E     A AS+ +   +++   V+Q         +V       + +L+
Sbjct: 793  LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN------QVYSMSSTYIDKLK 846

Query: 1235 DELNRAKSTLEAETRVK--QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSERE 1292
                  K+T  AE  VK  +   CE++ +  D N  +   S     +++  SE ++  + 
Sbjct: 847  TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS----TLKQWRSEVDEKRQV 902

Query: 1293 KNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHR 1352
             ++L  E+++ +A            + D   +T  + + +   ++ + D+L +R    H 
Sbjct: 903  FHALEDELQKAKA------------ISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHV 950

Query: 1353 ETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPF 1412
            +        +D      +G+ K   +++ Y         LD  ++  ++ +    E QP 
Sbjct: 951  Q--------IDNRLRDLEGIGK---SLKYYRDTY---HPLDDWIQQVETTQRKIQENQP- 995

Query: 1413 LRGAGSIAGASASPKEKYSLVEAKRKKLISPE-------STVMLLEAQAAT-GGIIDPHR 1464
               + ++A      K   S +E K+ K+   +       +TV   E Q  T   ++D  +
Sbjct: 996  -ENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054

Query: 1465 N---EKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRET 1521
                ++  + S+    + +F D +  Y A   +      F+G ++   E  +K+L + + 
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114

Query: 1522 GMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKK 1581
                                V   K++      I + L       +D++K    P +K+K
Sbjct: 1115 ------------------EHVEKAKELQKWVSNISKTL-------KDAEKAGKPPFSKQK 1149

Query: 1582 VSYVQL---KERCRIEPHTGLLLLSVQKRSMSFQGIRQ-PVTVTELVDS-GILRPSTVNE 1636
            +S  ++   KE+      T  L L+     M+ +   +    V  L +S  +L   ++ +
Sbjct: 1150 ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQ 1209

Query: 1637 LESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQ 1696
            L+  Q S D   E   D       IAG  ++TT + L +++A+  GL+   T + LLE Q
Sbjct: 1210 LQESQTSGDVKVEEKLD-----KVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264

Query: 1697 AATGFIVDPVSNLRLPVEEAYKRGLVGIEF--KEKLLSAERAVTGYNDPETGNIISLFQA 1754
                 ++ P       +++A   GL+  +   + K LS  + +     P T   I +  A
Sbjct: 1265 LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDA 1321

Query: 1755 MNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTK 1814
            + + +I +   I++LE  ++TG ++ P    +L +  A+++   +  L   + +  +  K
Sbjct: 1322 LAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCK 1381

Query: 1815 GFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPET 1874
               DP T E ++ + + +R    E TG+ LLP++      Q   + TL+           
Sbjct: 1382 DLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRP-----QEGGRITLK----------C 1426

Query: 1875 NKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDA 1934
             + +S+  A  +GLID ET   L   +       ++G        L++  +G +  +++A
Sbjct: 1427 GRNISILRAAHEGLIDRETMFRLLSAQL------LSGG-------LINSNSGQRMTVEEA 1473

Query: 1935 IDKGLVDRKFFD-----QYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH- 1988
            + +G++DR         Q ++G +  +  A  +++   V       S     + +   + 
Sbjct: 1474 VREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYV 1533

Query: 1989 -----ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIV 2043
                  S     T SS++   I +      L     IAA++  E+ + I +    + GI+
Sbjct: 1534 GLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGII 1593

Query: 2044 DSITGQRL 2051
            D+ T   L
Sbjct: 1594 DNNTASIL 1601



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 97/390 (24%), Positives = 164/390 (42%), Gaps = 54/390 (13%)

Query: 1800 EELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQ- 1858
            E+LSE L           D  T+E    L+ + + +++       L   E  KQ+Q SQ 
Sbjct: 1160 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN----LLFSESLKQLQESQT 1215

Query: 1859 ------KNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGS 1912
                  +  L K     +D  T + +SV +A  +GLIDY+T   L E +     + I+G 
Sbjct: 1216 SGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ-----LMISG- 1269

Query: 1913 DGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSS 1972
                   L+  +    +D++DA   GL+D +           L Q  ++   K  +  +S
Sbjct: 1270 -------LISPELRKCFDLKDAKSHGLIDEQI----------LCQLKELSKAKEIISAAS 1312

Query: 1973 SMGSGVSDDVFSSSRHESVS------KISTISSVRNLT--------------IRSSSFSD 2012
                 V D +  S   ES++       +ST S V   T              + S+ FS 
Sbjct: 1313 PTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSK 1372

Query: 2013 TLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSL 2072
             LE  +    + D    EK+S+ + ++R  +   TG  LL  +   GG I    G+ +S+
Sbjct: 1373 VLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISI 1432

Query: 2073 QDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQY 2132
              A  +G+ID++   RL  AQ    G       ++M+  EAV+E  +  +     L +Q 
Sbjct: 1433 LRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492

Query: 2133 LTGGLVDPEVHGRISTEEAIRKGFIDGRAA 2162
             TGG++      R++ +EA++   I   +A
Sbjct: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSA 1522



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 93/458 (20%), Positives = 190/458 (41%), Gaps = 67/458 (14%)

Query: 1713 VEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQ 1772
            ++E+   G V +E  EKL   ++ + G  D  TG ++S+FQA+ + LI+   GIRLLE Q
Sbjct: 1210 LQESQTSGDVKVE--EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264

Query: 1773 IATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKE 1832
            +   G+I P+      +  A   G  +E++   L + S   K      +   +  L    
Sbjct: 1265 LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSK-AKEIISAASPTTIPVLDALA 1323

Query: 1833 RCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYE 1892
            + +  E   + +L +      + T            +V P T +++++Q+A+++ L+   
Sbjct: 1324 QSMITESMAIKVLEIL-----LSTGS----------LVIPATGEQLTLQKAFQQNLVSSA 1368

Query: 1893 TFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGS 1952
             F ++ E++   ++             L+D  T  +  + D + +  +      Q  +G 
Sbjct: 1369 LFSKVLERQNMCKD-------------LIDPCTSEKVSLIDMVQRSTL------QENTGM 1409

Query: 1953 LSLT---QFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSS 2009
              L    Q    I+LK G   S              + HE +    T+  + +  + S  
Sbjct: 1410 WLLPVRPQEGGRITLKCGRNIS-----------ILRAAHEGLIDRETMFRLLSAQLLSGG 1458

Query: 2010 FSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2069
                         + ++ + +++++ E +  G++D  T   +L  Q  TGGII     ++
Sbjct: 1459 -------------LINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKR 1505

Query: 2070 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2129
            L++ +AV   +I    A  +  AQ+ ++G       +    + +++++ +  E   + L 
Sbjct: 1506 LTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILN 1565

Query: 2130 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQD 2167
             +     L  PE    I  + A + G ID   A  L++
Sbjct: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 65/246 (26%), Positives = 109/246 (44%), Gaps = 32/246 (13%)

Query: 1980 DDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSP-------------IAAIFDT 2026
            D +    R+E   ++ T+    NL    S     L+ES               IA   D 
Sbjct: 1178 DKMTDEERNELEKQVKTLQESYNLLFSESL--KQLQESQTSGDVKVEEKLDKVIAGTIDQ 1235

Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
               E +S+ + + RG++D  TG RLLE Q    G+I P   +   L+DA S G+ID+ + 
Sbjct: 1236 TTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQIL 1295

Query: 2087 TRLKPAQKAFIGFEGVKGKKKMSAA--------EAVKEKWLPYEAGQRFLEFQYLTGGLV 2138
             +LK   KA         K+ +SAA        +A+ +  +      + LE    TG LV
Sbjct: 1296 CQLKELSKA---------KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLV 1346

Query: 2139 DPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDI 2198
             P    +++ ++A ++  +      ++ +  +  K L  P T  K+S  D + RS +++ 
Sbjct: 1347 IPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQEN 1406

Query: 2199 TGLRLL 2204
            TG+ LL
Sbjct: 1407 TGMWLL 1412



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 155/853 (18%), Positives = 335/853 (39%), Gaps = 107/853 (12%)

Query: 902  LYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDK----SEEVQKIAELCANS 957
            LY+ K  +   E     D N +   ++  K   SE+  KR       +E+QK   +    
Sbjct: 864  LYETKLCE---EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM 920

Query: 958  IKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFL 1017
             K Y+ +   +    E          +++    V +Q   D   R +E + +S  YYR  
Sbjct: 921  FKTYKERDLDFDWHKEKA------DQLVERWQNVHVQ--IDNRLRDLEGIGKSLKYYR-- 970

Query: 1018 SEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQKYQA---ECS 1070
             +    L+D      ++E  + +++  +  NS+      N+ K L   ++  Q+   EC 
Sbjct: 971  -DTYHPLDDWI---QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ 1026

Query: 1071 QFKAKLAS------LEELKRQAELDGKSA--------KQNLDKCYGQIKELNEK----IT 1112
            ++  + ++      L+ +  +A +D +          + + D    +  +L  +    +T
Sbjct: 1027 KYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVT 1086

Query: 1113 RLTYEIE---DEKRRRKSVEDRFDQQKNDYDQLQKARQCEK--ENLGWQKLESEKAIKEK 1167
             +T  I+   D  +R +  E   +++K ++  ++KA++ +K   N+     ++EKA K  
Sbjct: 1087 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEH--VEKAKELQKWVSNISKTLKDAEKAGKPP 1144

Query: 1168 EYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1227
                 + ++  +E  T+K +    L      + +  ++ T   +ER  L  ++K L Q+ 
Sbjct: 1145 ---FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD--EERNELEKQVKTL-QES 1198

Query: 1228 ARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEA--------- 1278
              L   E      +S    + +V+++L+   + I   ++Q   +     +A         
Sbjct: 1199 YNLLFSESLKQLQESQTSGDVKVEEKLD---KVIAGTIDQTTGEVLSVFQAVLRGLIDYD 1255

Query: 1279 --IRKIESEREKSEREKNSLRSEIERLQAEIKR-IEERCRRKLEDSTRETQSQLETERSR 1335
              IR +E++   S      LR   +   A+    I+E+   +L++ ++  +  +      
Sbjct: 1256 TGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEI-ISAASPT 1314

Query: 1336 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1395
                +D L Q         +   E  + T  LV     +++T  + ++  L+      K+
Sbjct: 1315 TIPVLDALAQSMITESMAIKV-LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373

Query: 1396 LKGKKSVEEVASEI------------QPFLRGAGSIAGASASPKE----------KYSLV 1433
            L+ +   +++                +  L+    +      P+E            S++
Sbjct: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISIL 1433

Query: 1434 EAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKA 1493
             A  + LI  E+   LL AQ  +GG+I+ +  +++TV+ A+   +ID D    I   +  
Sbjct: 1434 RAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQ 1493

Query: 1494 ITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARG 1553
              G       K ++V EA++ +LI   + + +LEAQ    G++ P +    P   +L + 
Sbjct: 1494 TGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQE 1553

Query: 1554 LIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL--LSVQKRSMSF 1611
            LI  +L   + + R        P + + +     K+   I+ +T  +L  +++  +    
Sbjct: 1554 LITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDL 1613

Query: 1612 QGIRQPVTVTELVDSGILRPSTVNELESGQISYD-------EVGERIKDFLQGSSCIAGI 1664
              +         +     +PSTV++    +  +D       +  E  K        I   
Sbjct: 1614 GDLEACKNARRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSY 1673

Query: 1665 YNETTKQKLGIYE 1677
             +  T Q+L +Y+
Sbjct: 1674 MDANTGQRLLLYD 1686


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  577 bits (1488), Expect = e-164
 Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 630  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 689

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 690  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 750  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 809

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 810  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 869

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 870  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 929

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 930  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 989

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 990  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1049

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 1050 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1081

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 1082 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1140

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 1141 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1200

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 1201 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1260

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 1261 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1320

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 1321 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1380

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1381 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1440

Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
            T    Y +F  + LK L  E+  L+  K E +E             + L+ A  A     
Sbjct: 1441 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1500

Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
            +K K   + +   + + S+       F AK      +E + + E   K+ +++ +  + +
Sbjct: 1501 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1560

Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
             +K+L E  T    ++E++         K + + + D   Q +N     Q+A       +
Sbjct: 1561 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1620

Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
              +K +S++   +K+ +         ++     L+E G +  + +  L +   ++ E+K 
Sbjct: 1621 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1678

Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
            +C Q+                  ++E    +  +K LE+ K +++ L D L N  K +  
Sbjct: 1679 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1738

Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
            A T+ KQ +E                E+ ++  +L       Q  T      +  +K+++
Sbjct: 1739 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1798

Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
            + EK   +  ++    +  Q  +++    +    + KL+ + +E +   ET  +  ++++
Sbjct: 1799 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1858



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 3294 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3344

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 3345 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3403

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3404 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3456

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
             ++   + + L + E +    T+   LEE++   +    +  N NK L Q +   Q    
Sbjct: 3457 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3509

Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
                   SL+ L  + + D   +K +  +  Y +I+E +   + L  + + + K   +  
Sbjct: 3510 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3562

Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
             +  +     +D+L K    +    G  K +SE            LRVL ++   RK+  
Sbjct: 3563 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3610

Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
            +  L      ++++      ++Q++         LE  KAR + +         TLE   
Sbjct: 3611 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3661

Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
            ++ +RL    ++       ++ +L  ++TQ  + EEA +     +E  +  KN+   L S
Sbjct: 3662 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3721

Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
              E   A ++ +  R R  LE    E   +   +    ++   EID    R     +   
Sbjct: 3722 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3781

Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
             E  W  +T K +       L +  T+ QL     + KT   ++L+ K  ++++      
Sbjct: 3782 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3833

Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
                +G     + S +EK S+ + K  K++    T+  + ++
Sbjct: 3834 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3870



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 4214 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4272

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 4273 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4304

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 4305 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4356

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4416

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4417 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4463

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4464 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4517

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4518 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4576

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4577 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4624

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4625 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4678

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        +K
Sbjct: 4679 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4726

Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
             L++ ++ L  + +    +    +++ ++      Q   A Q   + L   ++E + A  
Sbjct: 4727 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4783

Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
            +  + +I+ +  L+       + ++ EL K ++ +Q  K    ++++        +KV  
Sbjct: 4784 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4839

Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
            Q+ +        L+ +K T LEA  R  +    E   + + L +W    +  E+ +R   
Sbjct: 4840 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 4889

Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
                    ++++LR+ I++ +  +K++EE+ R +L  +T
Sbjct: 4890 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4926



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            QN  QA+   L  LK         ++   +Q+++  +  + ++I  ++     +L     
Sbjct: 3608 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3662

Query: 773  LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            L + +  T + L  +    E  L   ET  L  ++    +   K++K +    K+LL ++
Sbjct: 3663 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3722

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
                    ++ S   +  P    +     + V +  +R++ +   I  ++ +++  I + 
Sbjct: 3723 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3773

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
            + +     A   W+ + +++  SL  ++     T  + L  QK    EI   +D  +++ 
Sbjct: 3774 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3832

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
            K       +  + E Q  S    L+ +L        I S   + L+ A  +  ++ E   
Sbjct: 3833 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3890

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
                +      ++  L    L+   +   +EE R  R+  +E+       NK   Q L+ 
Sbjct: 3891 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3950

Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
               E    + K  + + L  Q + D K     LD+   Q  + ++KI ++   +E   E+
Sbjct: 3951 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4010

Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
             R+        + ++++  + KN   D ++LQ   +  K+        + G  K  S KA
Sbjct: 4011 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4070

Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
            +++K  ++    E +  L++E   +  +   ELA+        +  +       +++ E 
Sbjct: 4071 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4129

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
              +   V++Q +   + + +E++  +  L+    +   L     E +K  ++  +++   
Sbjct: 4130 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4189

Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
             W +     ++ I K+E   + + + ++ L+             + +  +  +++ ++++
Sbjct: 4190 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4249

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
                 +  +   Q Q+E ER  +Q E+  L++    S + T  +    +   KL++D L 
Sbjct: 4250 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4305

Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
            +++   Q   E  L+     +  LD+LL      E + SE +P
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4348



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
            L Q  +  +  L+     LT+ +TV   L +    +  +  +   L++  ++L T + ++
Sbjct: 2552 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2611

Query: 833  QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
            Q   Q  +    QY             P  D  L G   E++  +T +W  +  Q+  R 
Sbjct: 2612 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2671

Query: 879  WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
              +++ I +   Y+   ++    L D   +  S  ++     + + + L   + +  EI 
Sbjct: 2672 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2730

Query: 939  GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
             ++ + +  Q + E  +  +K+  L+ A  +  LE +L            S   +++ A+
Sbjct: 2731 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2778

Query: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
             H ++++    S   ++ +S   ++  D K +        + K++VLE  ++  +D +  
Sbjct: 2779 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2838

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
               ++   ++ +    AE      K    E+   Q +L+  + K N D    Q+KE   K
Sbjct: 2839 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2892

Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
            +      +E   + ++ VE  +       + L++ + C     G   +   K++ KE + 
Sbjct: 2893 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2949

Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
                + +L            N  A +   + E   +   V  E +SL+ K+  V EQ  +
Sbjct: 2950 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 2995

Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
            +   LE+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++
Sbjct: 2996 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3055

Query: 1281 KIESEREKSER 1291
             ++ + + ++R
Sbjct: 3056 ALKHQVDLAKR 3066



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 3996 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 4056 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4115

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 4116 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4166

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 4167 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4219

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 4220 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4278

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 4279 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4332

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 4333 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4391

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4392 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4448

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4449 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4508

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
            ++ I   + + E +   L E  T+  E  N   +  N +Q+  N  TQ      V  R S
Sbjct: 4509 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4568

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
            L++   + + D+ ++   E   +R +     +T    +   +KQ    I+N L    ++W
Sbjct: 4569 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628

Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
            +    R  E  R ++  R+++++   +    +E L+   K ++
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4671



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4779 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4836

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 4897 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4953

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 4954 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5010

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 5011 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5070

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 5071 SLYPSGSQTQIETKNPRVNLLVSKW 5095



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2494 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2553

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2554 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2608

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE      T+  + +L+ P +   ++   G+
Sbjct: 2609 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2648

Query: 992  ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
            + ++ A V  ++  L  +       LS+    ++   +K+T+ + L   LR   D  S+ 
Sbjct: 2649 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2698

Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
             NK   L  +L            +L + +++K++ + + K  K     C      + E+ 
Sbjct: 2699 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2754

Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
             +  L+ ++E   +  K VE +    +N    LQ A       +Q  ++   W  L+++K
Sbjct: 2755 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2809

Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
              + K + I     +L+      +++   L   S+  +++       + E E+LL+K + 
Sbjct: 2810 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2862

Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
             E+   +LQ             ++++  N+ K +LE   + K+++E     I   QN+L 
Sbjct: 2863 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2922

Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
            + K     +  E +I K++S     ++E +     +E L      +   C    E  T E
Sbjct: 2923 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2978

Query: 1325 TQSQLE 1330
             +S ++
Sbjct: 2979 NKSLIQ 2984



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)

Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
            KSLED K    K  +   E++   ++    CN             A  +  KA +A+++ 
Sbjct: 2352 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2400

Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
                A L+G+    N ++ +    +  + + +T +++  ED     K   D+  +     
Sbjct: 2401 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2455

Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
             +LQKA++     + W +  ++ A K ++         ++ +  + + +E EL +  N++
Sbjct: 2456 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2515

Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
            QE K++ T++++E          + +L +I    Q+  +L     Q+LE+  N       
Sbjct: 2516 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2575

Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
             E ++KQ L  EK+        +  D N   TQ  + +  +++  + + + E+
Sbjct: 2576 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2627



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5439 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5466



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5446 SRPGSRAGSKAGSRASSRRGSDASDFD 5472



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5424 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5466


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  577 bits (1488), Expect = e-164
 Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 641  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 701  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 761  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 821  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 881  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 941  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1092

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 1093 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1151

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 1152 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1211

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1271

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 1272 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1331

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 1332 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1391

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1392 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1451

Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
            T    Y +F  + LK L  E+  L+  K E +E             + L+ A  A     
Sbjct: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511

Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
            +K K   + +   + + S+       F AK      +E + + E   K+ +++ +  + +
Sbjct: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1571

Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
             +K+L E  T    ++E++         K + + + D   Q +N     Q+A       +
Sbjct: 1572 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1631

Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
              +K +S++   +K+ +         ++     L+E G +  + +  L +   ++ E+K 
Sbjct: 1632 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1689

Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
            +C Q+                  ++E    +  +K LE+ K +++ L D L N  K +  
Sbjct: 1690 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1749

Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
            A T+ KQ +E                E+ ++  +L       Q  T      +  +K+++
Sbjct: 1750 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1809

Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
            + EK   +  ++    +  Q  +++    +    + KL+ + +E +   ET  +  ++++
Sbjct: 1810 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1869



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 3305 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 3356 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3414

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3415 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3467

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
             ++   + + L + E +    T+   LEE++   +    +  N NK L Q +   Q    
Sbjct: 3468 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3520

Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
                   SL+ L  + + D   +K +  +  Y +I+E +   + L  + + + K   +  
Sbjct: 3521 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3573

Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
             +  +     +D+L K    +    G  K +SE            LRVL ++   RK+  
Sbjct: 3574 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3621

Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
            +  L      ++++      ++Q++         LE  KAR + +         TLE   
Sbjct: 3622 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3672

Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
            ++ +RL    ++       ++ +L  ++TQ  + EEA +     +E  +  KN+   L S
Sbjct: 3673 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3732

Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
              E   A ++ +  R R  LE    E   +   +    ++   EID    R     +   
Sbjct: 3733 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3792

Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
             E  W  +T K +       L +  T+ QL     + KT   ++L+ K  ++++      
Sbjct: 3793 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3844

Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
                +G     + S +EK S+ + K  K++    T+  + ++
Sbjct: 3845 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3881



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 4225 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4283

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 4284 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4315

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 4316 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4367

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4428 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4528

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4529 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4587

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4588 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4635

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4689

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        +K
Sbjct: 4690 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737

Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
             L++ ++ L  + +    +    +++ ++      Q   A Q   + L   ++E + A  
Sbjct: 4738 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4794

Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
            +  + +I+ +  L+       + ++ EL K ++ +Q  K    ++++        +KV  
Sbjct: 4795 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4850

Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
            Q+ +        L+ +K T LEA  R  +    E   + + L +W    +  E+ +R   
Sbjct: 4851 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 4900

Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
                    ++++LR+ I++ +  +K++EE+ R +L  +T
Sbjct: 4901 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4937



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            QN  QA+   L  LK         ++   +Q+++  +  + ++I  ++     +L     
Sbjct: 3619 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673

Query: 773  LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            L + +  T + L  +    E  L   ET  L  ++    +   K++K +    K+LL ++
Sbjct: 3674 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
                    ++ S   +  P    +     + V +  +R++ +   I  ++ +++  I + 
Sbjct: 3734 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3784

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
            + +     A   W+ + +++  SL  ++     T  + L  QK    EI   +D  +++ 
Sbjct: 3785 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3843

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
            K       +  + E Q  S    L+ +L        I S   + L+ A  +  ++ E   
Sbjct: 3844 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3901

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
                +      ++  L    L+   +   +EE R  R+  +E+       NK   Q L+ 
Sbjct: 3902 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3961

Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
               E    + K  + + L  Q + D K     LD+   Q  + ++KI ++   +E   E+
Sbjct: 3962 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4021

Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
             R+        + ++++  + KN   D ++LQ   +  K+        + G  K  S KA
Sbjct: 4022 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4081

Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
            +++K  ++    E +  L++E   +  +   ELA+        +  +       +++ E 
Sbjct: 4082 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4140

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
              +   V++Q +   + + +E++  +  L+    +   L     E +K  ++  +++   
Sbjct: 4141 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4200

Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
             W +     ++ I K+E   + + + ++ L+             + +  +  +++ ++++
Sbjct: 4201 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4260

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
                 +  +   Q Q+E ER  +Q E+  L++    S + T  +    +   KL++D L 
Sbjct: 4261 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4316

Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
            +++   Q   E  L+     +  LD+LL      E + SE +P
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4359



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
            L Q  +  +  L+     LT+ +TV   L +    +  +  +   L++  ++L T + ++
Sbjct: 2563 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2622

Query: 833  QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
            Q   Q  +    QY             P  D  L G   E++  +T +W  +  Q+  R 
Sbjct: 2623 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2682

Query: 879  WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
              +++ I +   Y+   ++    L D   +  S  ++     + + + L   + +  EI 
Sbjct: 2683 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2741

Query: 939  GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
             ++ + +  Q + E  +  +K+  L+ A  +  LE +L            S   +++ A+
Sbjct: 2742 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2789

Query: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
             H ++++    S   ++ +S   ++  D K +        + K++VLE  ++  +D +  
Sbjct: 2790 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2849

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
               ++   ++ +    AE      K    E+   Q +L+  + K N D    Q+KE   K
Sbjct: 2850 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2903

Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
            +      +E   + ++ VE  +       + L++ + C     G   +   K++ KE + 
Sbjct: 2904 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2960

Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
                + +L            N  A +   + E   +   V  E +SL+ K+  V EQ  +
Sbjct: 2961 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 3006

Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
            +   LE+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++
Sbjct: 3007 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3066

Query: 1281 KIESEREKSER 1291
             ++ + + ++R
Sbjct: 3067 ALKHQVDLAKR 3077



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 4127 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4177

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 4178 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4230

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 4231 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4289

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 4290 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4343

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 4344 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4402

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4403 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4459

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4460 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4519

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
            ++ I   + + E +   L E  T+  E  N   +  N +Q+  N  TQ      V  R S
Sbjct: 4520 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4579

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
            L++   + + D+ ++   E   +R +     +T    +   +KQ    I+N L    ++W
Sbjct: 4580 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639

Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
            +    R  E  R ++  R+++++   +    +E L+   K ++
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4682



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4790 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 4908 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 4965 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5021

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 5022 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5081

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 5082 SLYPSGSQTQIETKNPRVNLLVSKW 5106



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2619

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE      T+  + +L+ P +   ++   G+
Sbjct: 2620 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2659

Query: 992  ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
            + ++ A V  ++  L  +       LS+    ++   +K+T+ + L   LR   D  S+ 
Sbjct: 2660 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2709

Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
             NK   L  +L            +L + +++K++ + + K  K     C      + E+ 
Sbjct: 2710 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2765

Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
             +  L+ ++E   +  K VE +    +N    LQ A       +Q  ++   W  L+++K
Sbjct: 2766 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2820

Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
              + K + I     +L+      +++   L   S+  +++       + E E+LL+K + 
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2873

Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
             E+   +LQ             ++++  N+ K +LE   + K+++E     I   QN+L 
Sbjct: 2874 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2933

Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
            + K     +  E +I K++S     ++E +     +E L      +   C    E  T E
Sbjct: 2934 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2989

Query: 1325 TQSQLE 1330
             +S ++
Sbjct: 2990 NKSLIQ 2995



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)

Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
            KSLED K    K  +   E++   ++    CN             A  +  KA +A+++ 
Sbjct: 2363 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2411

Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
                A L+G+    N ++ +    +  + + +T +++  ED     K   D+  +     
Sbjct: 2412 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2466

Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
             +LQKA++     + W +  ++ A K ++         ++ +  + + +E EL +  N++
Sbjct: 2467 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2526

Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
            QE K++ T++++E          + +L +I    Q+  +L     Q+LE+  N       
Sbjct: 2527 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2586

Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
             E ++KQ L  EK+        +  D N   TQ  + +  +++  + + + E+
Sbjct: 2587 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2638



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5450 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5477



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5457 SRPGSRAGSKAGSRASSRRGSDASDFD 5483



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5435 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5477


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  577 bits (1488), Expect = e-164
 Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 779  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 838

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 839  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 899  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 958

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 959  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 1018

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 1019 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 1078

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 1079 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1138

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 1139 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1198

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 1199 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1230

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 1231 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1289

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 1290 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1349

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 1350 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1409

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 1410 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1469

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 1470 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1529

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1530 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1589

Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
            T    Y +F  + LK L  E+  L+  K E +E             + L+ A  A     
Sbjct: 1590 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1649

Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
            +K K   + +   + + S+       F AK      +E + + E   K+ +++ +  + +
Sbjct: 1650 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1709

Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
             +K+L E  T    ++E++         K + + + D   Q +N     Q+A       +
Sbjct: 1710 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1769

Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
              +K +S++   +K+ +         ++     L+E G +  + +  L +   ++ E+K 
Sbjct: 1770 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1827

Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
            +C Q+                  ++E    +  +K LE+ K +++ L D L N  K +  
Sbjct: 1828 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1887

Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
            A T+ KQ +E                E+ ++  +L       Q  T      +  +K+++
Sbjct: 1888 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1947

Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
            + EK   +  ++    +  Q  +++    +    + KL+ + +E +   ET  +  ++++
Sbjct: 1948 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 2007



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 3443 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3493

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 3494 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3552

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3553 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3605

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
             ++   + + L + E +    T+   LEE++   +    +  N NK L Q +   Q    
Sbjct: 3606 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3658

Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
                   SL+ L  + + D   +K +  +  Y +I+E +   + L  + + + K   +  
Sbjct: 3659 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3711

Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
             +  +     +D+L K    +    G  K +SE            LRVL ++   RK+  
Sbjct: 3712 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3759

Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
            +  L      ++++      ++Q++         LE  KAR + +         TLE   
Sbjct: 3760 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3810

Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
            ++ +RL    ++       ++ +L  ++TQ  + EEA +     +E  +  KN+   L S
Sbjct: 3811 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3870

Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
              E   A ++ +  R R  LE    E   +   +    ++   EID    R     +   
Sbjct: 3871 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3930

Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
             E  W  +T K +       L +  T+ QL     + KT   ++L+ K  ++++      
Sbjct: 3931 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3982

Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
                +G     + S +EK S+ + K  K++    T+  + ++
Sbjct: 3983 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 4019



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 4363 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4421

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 4422 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4453

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 4454 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4505

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4565

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4566 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4612

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4613 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4666

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4667 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4725

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4726 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4773

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4774 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4827

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        +K
Sbjct: 4828 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4875

Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
             L++ ++ L  + +    +    +++ ++      Q   A Q   + L   ++E + A  
Sbjct: 4876 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4932

Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
            +  + +I+ +  L+       + ++ EL K ++ +Q  K    ++++        +KV  
Sbjct: 4933 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4988

Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
            Q+ +        L+ +K T LEA  R  +    E   + + L +W    +  E+ +R   
Sbjct: 4989 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 5038

Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
                    ++++LR+ I++ +  +K++EE+ R +L  +T
Sbjct: 5039 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 5075



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            QN  QA+   L  LK         ++   +Q+++  +  + ++I  ++     +L     
Sbjct: 3757 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3811

Query: 773  LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            L + +  T + L  +    E  L   ET  L  ++    +   K++K +    K+LL ++
Sbjct: 3812 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3871

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
                    ++ S   +  P    +     + V +  +R++ +   I  ++ +++  I + 
Sbjct: 3872 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3922

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
            + +     A   W+ + +++  SL  ++     T  + L  QK    EI   +D  +++ 
Sbjct: 3923 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3981

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
            K       +  + E Q  S    L+ +L        I S   + L+ A  +  ++ E   
Sbjct: 3982 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 4039

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
                +      ++  L    L+   +   +EE R  R+  +E+       NK   Q L+ 
Sbjct: 4040 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 4099

Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
               E    + K  + + L  Q + D K     LD+   Q  + ++KI ++   +E   E+
Sbjct: 4100 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 4159

Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
             R+        + ++++  + KN   D ++LQ   +  K+        + G  K  S KA
Sbjct: 4160 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4219

Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
            +++K  ++    E +  L++E   +  +   ELA+        +  +       +++ E 
Sbjct: 4220 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4278

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
              +   V++Q +   + + +E++  +  L+    +   L     E +K  ++  +++   
Sbjct: 4279 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4338

Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
             W +     ++ I K+E   + + + ++ L+             + +  +  +++ ++++
Sbjct: 4339 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4398

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
                 +  +   Q Q+E ER  +Q E+  L++    S + T  +    +   KL++D L 
Sbjct: 4399 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4454

Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
            +++   Q   E  L+     +  LD+LL      E + SE +P
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4497



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
            L Q  +  +  L+     LT+ +TV   L +    +  +  +   L++  ++L T + ++
Sbjct: 2701 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2760

Query: 833  QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
            Q   Q  +    QY             P  D  L G   E++  +T +W  +  Q+  R 
Sbjct: 2761 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2820

Query: 879  WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
              +++ I +   Y+   ++    L D   +  S  ++     + + + L   + +  EI 
Sbjct: 2821 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2879

Query: 939  GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
             ++ + +  Q + E  +  +K+  L+ A  +  LE +L            S   +++ A+
Sbjct: 2880 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2927

Query: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
             H ++++    S   ++ +S   ++  D K +        + K++VLE  ++  +D +  
Sbjct: 2928 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2987

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
               ++   ++ +    AE      K    E+   Q +L+  + K N D    Q+KE   K
Sbjct: 2988 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 3041

Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
            +      +E   + ++ VE  +       + L++ + C     G   +   K++ KE + 
Sbjct: 3042 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 3098

Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
                + +L            N  A +   + E   +   V  E +SL+ K+  V EQ  +
Sbjct: 3099 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 3144

Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
            +   LE+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++
Sbjct: 3145 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3204

Query: 1281 KIESEREKSER 1291
             ++ + + ++R
Sbjct: 3205 ALKHQVDLAKR 3215



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 4145 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 4205 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4264

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 4265 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4315

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 4316 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4368

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 4369 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4427

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 4428 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4481

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 4482 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4540

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4541 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4597

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4598 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4657

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
            ++ I   + + E +   L E  T+  E  N   +  N +Q+  N  TQ      V  R S
Sbjct: 4658 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4717

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
            L++   + + D+ ++   E   +R +     +T    +   +KQ    I+N L    ++W
Sbjct: 4718 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777

Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
            +    R  E  R ++  R+++++   +    +E L+   K ++
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4820



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4928 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4985

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 5046 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 5102

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 5103 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5159

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 5160 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5219

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 5220 SLYPSGSQTQIETKNPRVNLLVSKW 5244



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2643 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2702

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2703 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2757

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE      T+  + +L+ P +   ++   G+
Sbjct: 2758 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2797

Query: 992  ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
            + ++ A V  ++  L  +       LS+    ++   +K+T+ + L   LR   D  S+ 
Sbjct: 2798 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2847

Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
             NK   L  +L            +L + +++K++ + + K  K     C      + E+ 
Sbjct: 2848 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2903

Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
             +  L+ ++E   +  K VE +    +N    LQ A       +Q  ++   W  L+++K
Sbjct: 2904 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2958

Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
              + K + I     +L+      +++   L   S+  +++       + E E+LL+K + 
Sbjct: 2959 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 3011

Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
             E+   +LQ             ++++  N+ K +LE   + K+++E     I   QN+L 
Sbjct: 3012 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 3071

Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
            + K     +  E +I K++S     ++E +     +E L      +   C    E  T E
Sbjct: 3072 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 3127

Query: 1325 TQSQLE 1330
             +S ++
Sbjct: 3128 NKSLIQ 3133



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)

Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
            KSLED K    K  +   E++   ++    CN             A  +  KA +A+++ 
Sbjct: 2501 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2549

Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
                A L+G+    N ++ +    +  + + +T +++  ED     K   D+  +     
Sbjct: 2550 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2604

Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
             +LQKA++     + W +  ++ A K ++         ++ +  + + +E EL +  N++
Sbjct: 2605 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2664

Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
            QE K++ T++++E          + +L +I    Q+  +L     Q+LE+  N       
Sbjct: 2665 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2724

Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
             E ++KQ L  EK+        +  D N   TQ  + +  +++  + + + E+
Sbjct: 2725 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2776



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5588 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5615



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5595 SRPGSRAGSKAGSRASSRRGSDASDFD 5621



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5573 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5615


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  577 bits (1488), Expect = e-164
 Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1052

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 1053 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1111

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 1112 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1171

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1231

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 1232 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1291

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 1292 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1351

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1352 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1411

Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
            T    Y +F  + LK L  E+  L+  K E +E             + L+ A  A     
Sbjct: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471

Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
            +K K   + +   + + S+       F AK      +E + + E   K+ +++ +  + +
Sbjct: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1531

Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
             +K+L E  T    ++E++         K + + + D   Q +N     Q+A       +
Sbjct: 1532 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1591

Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
              +K +S++   +K+ +         ++     L+E G +  + +  L +   ++ E+K 
Sbjct: 1592 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1649

Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
            +C Q+                  ++E    +  +K LE+ K +++ L D L N  K +  
Sbjct: 1650 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1709

Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
            A T+ KQ +E                E+ ++  +L       Q  T      +  +K+++
Sbjct: 1710 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1769

Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
            + EK   +  ++    +  Q  +++    +    + KL+ + +E +   ET  +  ++++
Sbjct: 1770 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1829



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 3265 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 3316 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3374

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3375 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3427

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
             ++   + + L + E +    T+   LEE++   +    +  N NK L Q +   Q    
Sbjct: 3428 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3480

Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
                   SL+ L  + + D   +K +  +  Y +I+E +   + L  + + + K   +  
Sbjct: 3481 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3533

Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
             +  +     +D+L K    +    G  K +SE            LRVL ++   RK+  
Sbjct: 3534 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3581

Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
            +  L      ++++      ++Q++         LE  KAR + +         TLE   
Sbjct: 3582 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3632

Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
            ++ +RL    ++       ++ +L  ++TQ  + EEA +     +E  +  KN+   L S
Sbjct: 3633 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3692

Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
              E   A ++ +  R R  LE    E   +   +    ++   EID    R     +   
Sbjct: 3693 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3752

Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
             E  W  +T K +       L +  T+ QL     + KT   ++L+ K  ++++      
Sbjct: 3753 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3804

Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
                +G     + S +EK S+ + K  K++    T+  + ++
Sbjct: 3805 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3841



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 4185 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4243

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 4244 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4275

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 4276 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4327

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4388 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4488

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4489 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4547

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4548 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4595

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4649

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        +K
Sbjct: 4650 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697

Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
             L++ ++ L  + +    +    +++ ++      Q   A Q   + L   ++E + A  
Sbjct: 4698 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4754

Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
            +  + +I+ +  L+       + ++ EL K ++ +Q  K    ++++        +KV  
Sbjct: 4755 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4810

Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
            Q+ +        L+ +K T LEA  R  +    E   + + L +W    +  E+ +R   
Sbjct: 4811 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 4860

Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
                    ++++LR+ I++ +  +K++EE+ R +L  +T
Sbjct: 4861 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4897



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            QN  QA+   L  LK         ++   +Q+++  +  + ++I  ++     +L     
Sbjct: 3579 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3633

Query: 773  LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            L + +  T + L  +    E  L   ET  L  ++    +   K++K +    K+LL ++
Sbjct: 3634 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
                    ++ S   +  P    +     + V +  +R++ +   I  ++ +++  I + 
Sbjct: 3694 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3744

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
            + +     A   W+ + +++  SL  ++     T  + L  QK    EI   +D  +++ 
Sbjct: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3803

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
            K       +  + E Q  S    L+ +L        I S   + L+ A  +  ++ E   
Sbjct: 3804 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
                +      ++  L    L+   +   +EE R  R+  +E+       NK   Q L+ 
Sbjct: 3862 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3921

Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
               E    + K  + + L  Q + D K     LD+   Q  + ++KI ++   +E   E+
Sbjct: 3922 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981

Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
             R+        + ++++  + KN   D ++LQ   +  K+        + G  K  S KA
Sbjct: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041

Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
            +++K  ++    E +  L++E   +  +   ELA+        +  +       +++ E 
Sbjct: 4042 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4100

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
              +   V++Q +   + + +E++  +  L+    +   L     E +K  ++  +++   
Sbjct: 4101 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4160

Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
             W +     ++ I K+E   + + + ++ L+             + +  +  +++ ++++
Sbjct: 4161 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4220

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
                 +  +   Q Q+E ER  +Q E+  L++    S + T  +    +   KL++D L 
Sbjct: 4221 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4276

Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
            +++   Q   E  L+     +  LD+LL      E + SE +P
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4319



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
            L Q  +  +  L+     LT+ +TV   L +    +  +  +   L++  ++L T + ++
Sbjct: 2523 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2582

Query: 833  QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
            Q   Q  +    QY             P  D  L G   E++  +T +W  +  Q+  R 
Sbjct: 2583 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2642

Query: 879  WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
              +++ I +   Y+   ++    L D   +  S  ++     + + + L   + +  EI 
Sbjct: 2643 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2701

Query: 939  GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
             ++ + +  Q + E  +  +K+  L+ A  +  LE +L            S   +++ A+
Sbjct: 2702 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2749

Query: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
             H ++++    S   ++ +S   ++  D K +        + K++VLE  ++  +D +  
Sbjct: 2750 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2809

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
               ++   ++ +    AE      K    E+   Q +L+  + K N D    Q+KE   K
Sbjct: 2810 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2863

Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
            +      +E   + ++ VE  +       + L++ + C     G   +   K++ KE + 
Sbjct: 2864 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2920

Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
                + +L            N  A +   + E   +   V  E +SL+ K+  V EQ  +
Sbjct: 2921 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 2966

Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
            +   LE+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++
Sbjct: 2967 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3026

Query: 1281 KIESEREKSER 1291
             ++ + + ++R
Sbjct: 3027 ALKHQVDLAKR 3037



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 3967 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 4027 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4086

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 4087 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4137

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 4138 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4190

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 4191 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4249

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 4250 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4303

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 4304 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4362

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4363 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4419

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4420 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4479

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
            ++ I   + + E +   L E  T+  E  N   +  N +Q+  N  TQ      V  R S
Sbjct: 4480 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4539

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
            L++   + + D+ ++   E   +R +     +T    +   +KQ    I+N L    ++W
Sbjct: 4540 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599

Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
            +    R  E  R ++  R+++++   +    +E L+   K ++
Sbjct: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4642



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4750 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 4868 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4924

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 4925 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 4981

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 4982 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5041

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 5042 SLYPSGSQTQIETKNPRVNLLVSKW 5066



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2579

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE      T+  + +L+ P +   ++   G+
Sbjct: 2580 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2619

Query: 992  ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
            + ++ A V  ++  L  +       LS+    ++   +K+T+ + L   LR   D  S+ 
Sbjct: 2620 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2669

Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
             NK   L  +L            +L + +++K++ + + K  K     C      + E+ 
Sbjct: 2670 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2725

Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
             +  L+ ++E   +  K VE +    +N    LQ A       +Q  ++   W  L+++K
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2780

Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
              + K + I     +L+      +++   L   S+  +++       + E E+LL+K + 
Sbjct: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2833

Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
             E+   +LQ             ++++  N+ K +LE   + K+++E     I   QN+L 
Sbjct: 2834 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2893

Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
            + K     +  E +I K++S     ++E +     +E L      +   C    E  T E
Sbjct: 2894 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2949

Query: 1325 TQSQLE 1330
             +S ++
Sbjct: 2950 NKSLIQ 2955



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)

Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
            KSLED K    K  +   E++   ++    CN             A  +  KA +A+++ 
Sbjct: 2323 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2371

Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
                A L+G+    N ++ +    +  + + +T +++  ED     K   D+  +     
Sbjct: 2372 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2426

Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
             +LQKA++     + W +  ++ A K ++         ++ +  + + +E EL +  N++
Sbjct: 2427 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2486

Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
            QE K++ T++++E          + +L +I    Q+  +L     Q+LE+  N       
Sbjct: 2487 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2546

Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
             E ++KQ L  EK+        +  D N   TQ  + +  +++  + + + E+
Sbjct: 2547 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2598



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5410 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5437



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5417 SRPGSRAGSKAGSRASSRRGSDASDFD 5443



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5395 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5437


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  577 bits (1488), Expect = e-164
 Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085

Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
            T    Y +F  + LK L  E+  L+  K E +E             + L+ A  A     
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145

Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
            +K K   + +   + + S+       F AK      +E + + E   K+ +++ +  + +
Sbjct: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205

Query: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153
             +K+L E  T    ++E++         K + + + D   Q +N     Q+A       +
Sbjct: 1206 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1265

Query: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
              +K +S++   +K+ +         ++     L+E G +  + +  L +   ++ E+K 
Sbjct: 1266 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1323

Query: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245
            +C Q+                  ++E    +  +K LE+ K +++ L D L N  K +  
Sbjct: 1324 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1383

Query: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284
            A T+ KQ +E                E+ ++  +L       Q  T      +  +K+++
Sbjct: 1384 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1443

Query: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340
            + EK   +  ++    +  Q  +++    +    + KL+ + +E +   ET  +  ++++
Sbjct: 1444 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1503



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 2939 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 2989

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 2990 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3048

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3049 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3101

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
             ++   + + L + E +    T+   LEE++   +    +  N NK L Q +   Q    
Sbjct: 3102 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3154

Query: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128
                   SL+ L  + + D   +K +  +  Y +I+E +   + L  + + + K   +  
Sbjct: 3155 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3207

Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188
             +  +     +D+L K    +    G  K +SE            LRVL ++   RK+  
Sbjct: 3208 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3255

Query: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248
            +  L      ++++      ++Q++         LE  KAR + +         TLE   
Sbjct: 3256 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3306

Query: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298
            ++ +RL    ++       ++ +L  ++TQ  + EEA +     +E  +  KN+   L S
Sbjct: 3307 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3366

Query: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355
              E   A ++ +  R R  LE    E   +   +    ++   EID    R     +   
Sbjct: 3367 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3426

Query: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411
             E  W  +T K +       L +  T+ QL     + KT   ++L+ K  ++++      
Sbjct: 3427 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3478

Query: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453
                +G     + S +EK S+ + K  K++    T+  + ++
Sbjct: 3479 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3515



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 145/819 (17%), Positives = 331/819 (40%), Gaps = 130/819 (15%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 3859 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 3917

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 3918 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 3949

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 3950 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4001

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4061

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4062 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4108

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4109 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4162

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4163 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4221

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4222 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4269

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4270 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4323

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        +K
Sbjct: 4324 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4371

Query: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK 1165
             L++ ++ L  + +    +    +++ ++      Q   A Q   + L   ++E + A  
Sbjct: 4372 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL--YRVEPQLAED 4428

Query: 1166 EKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLE 1224
            +  + +I+ +  L+       + ++ EL K ++ +Q  K    ++++        +KV  
Sbjct: 4429 QPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQM 4484

Query: 1225 QDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIE 1283
            Q+ +        L+ +K T LEA  R  +    E   + + L +W    +  E+ +R   
Sbjct: 4485 QELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR--- 4534

Query: 1284 SEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322
                    ++++LR+ I++ +  +K++EE+ R +L  +T
Sbjct: 4535 -FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4571



 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            QN  QA+   L  LK         ++   +Q+++  +  + ++I  ++     +L     
Sbjct: 3253 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3307

Query: 773  LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            L + +  T + L  +    E  L   ET  L  ++    +   K++K +    K+LL ++
Sbjct: 3308 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3367

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
                    ++ S   +  P    +     + V +  +R++ +   I  ++ +++  I + 
Sbjct: 3368 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3418

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
            + +     A   W+ + +++  SL  ++     T  + L  QK    EI   +D  +++ 
Sbjct: 3419 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3477

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
            K       +  + E Q  S    L+ +L        I S   + L+ A  +  ++ E   
Sbjct: 3478 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3535

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064
                +      ++  L    L+   +   +EE R  R+  +E+       NK   Q L+ 
Sbjct: 3536 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3595

Query: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122
               E    + K  + + L  Q + D K     LD+   Q  + ++KI ++   +E   E+
Sbjct: 3596 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3655

Query: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163
             R+        + ++++  + KN   D ++LQ   +  K+        + G  K  S KA
Sbjct: 3656 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 3715

Query: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215
            +++K  ++    E +  L++E   +  +   ELA+        +  +       +++ E 
Sbjct: 3716 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 3774

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267
              +   V++Q +   + + +E++  +  L+    +   L     E +K  ++  +++   
Sbjct: 3775 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 3834

Query: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313
             W +     ++ I K+E   + + + ++ L+             + +  +  +++ ++++
Sbjct: 3835 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 3894

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
                 +  +   Q Q+E ER  +Q E+  L++    S + T  +    +   KL++D L 
Sbjct: 3895 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 3950

Query: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411
            +++   Q   E  L+     +  LD+LL      E + SE +P
Sbjct: 3951 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 3993



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
            L Q  +  +  L+     LT+ +TV   L +    +  +  +   L++  ++L T + ++
Sbjct: 2197 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2256

Query: 833  QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878
            Q   Q  +    QY             P  D  L G   E++  +T +W  +  Q+  R 
Sbjct: 2257 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2316

Query: 879  WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
              +++ I +   Y+   ++    L D   +  S  ++     + + + L   + +  EI 
Sbjct: 2317 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2375

Query: 939  GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
             ++ + +  Q + E  +  +K+  L+ A  +  LE +L            S   +++ A+
Sbjct: 2376 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2423

Query: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050
             H ++++    S   ++ +S   ++  D K +        + K++VLE  ++  +D +  
Sbjct: 2424 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2483

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110
               ++   ++ +    AE      K    E+   Q +L+  + K N D    Q+KE   K
Sbjct: 2484 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2537

Query: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169
            +      +E   + ++ VE  +       + L++ + C     G   +   K++ KE + 
Sbjct: 2538 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2594

Query: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228
                + +L            N  A +   + E   +   V  E +SL+ K+  V EQ  +
Sbjct: 2595 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 2640

Query: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280
            +   LE+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++
Sbjct: 2641 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 2700

Query: 1281 KIESEREKSER 1291
             ++ + + ++R
Sbjct: 2701 ALKHQVDLAKR 2711



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 3641 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 3701 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 3760

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 3761 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 3811

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 3812 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 3864

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 3865 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 3923

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 3924 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 3977

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 3978 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4036

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4037 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4093

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4094 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4153

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215
            ++ I   + + E +   L E  T+  E  N   +  N +Q+  N  TQ      V  R S
Sbjct: 4154 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4213

Query: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268
            L++   + + D+ ++   E   +R +     +T    +   +KQ    I+N L    ++W
Sbjct: 4214 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4273

Query: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311
            +    R  E  R ++  R+++++   +    +E L+   K ++
Sbjct: 4274 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4316



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4424 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4481

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 4542 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4598

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 4599 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 4655

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 4656 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 4715

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 4716 SLYPSGSQTQIETKNPRVNLLVSKW 4740



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2139 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2198

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2199 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2253

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE      T+  + +L+ P +   ++   G+
Sbjct: 2254 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2293

Query: 992  ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051
            + ++ A V  ++  L  +       LS+    ++   +K+T+ + L   LR   D  S+ 
Sbjct: 2294 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2343

Query: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111
             NK   L  +L            +L + +++K++ + + K  K     C      + E+ 
Sbjct: 2344 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2399

Query: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162
             +  L+ ++E   +  K VE +    +N    LQ A       +Q  ++   W  L+++K
Sbjct: 2400 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2454

Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
              + K + I     +L+      +++   L   S+  +++       + E E+LL+K + 
Sbjct: 2455 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2507

Query: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266
             E+   +LQ             ++++  N+ K +LE   + K+++E     I   QN+L 
Sbjct: 2508 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2567

Query: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324
            + K     +  E +I K++S     ++E +     +E L      +   C    E  T E
Sbjct: 2568 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2623

Query: 1325 TQSQLE 1330
             +S ++
Sbjct: 2624 NKSLIQ 2629



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)

Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
            KSLED K    K  +   E++   ++    CN             A  +  KA +A+++ 
Sbjct: 1997 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2045

Query: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
                A L+G+    N ++ +    +  + + +T +++  ED     K   D+  +     
Sbjct: 2046 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2100

Query: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199
             +LQKA++     + W +  ++ A K ++         ++ +  + + +E EL +  N++
Sbjct: 2101 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2160

Query: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245
            QE K++ T++++E          + +L +I    Q+  +L     Q+LE+  N       
Sbjct: 2161 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2220

Query: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291
             E ++KQ L  EK+        +  D N   TQ  + +  +++  + + + E+
Sbjct: 2221 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2272



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5084 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5111



 Score = 35.4 bits (80), Expect = 0.64
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5091 SRPGSRAGSKAGSRASSRRGSDASDFD 5117



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5069 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5111


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  516 bits (1328), Expect = e-145
 Identities = 365/1351 (27%), Positives = 673/1351 (49%), Gaps = 120/1351 (8%)

Query: 178  SGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDY------ 231
            S  DE       E L W+ + + +++   WG DL SVE  + + + IH S+ +       
Sbjct: 579  SSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKE 638

Query: 232  -RWQLDKIKADLREKSA--IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIND 288
             R    K+  +     A  + +LE +Y  L + S  RM HL+ L   +   + E++W+N+
Sbjct: 639  ARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNE 698

Query: 289  CEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIE 348
             EEEEL YDWSD N+NI+ K+  FS    +LE K+     L+  ++ L L  HPA   +E
Sbjct: 699  KEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVE 758

Query: 349  AYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKN 408
            AY   +Q+Q  W+ Q+  C++ H+KEN AYFQFF +A+  E++L+ LQDSI++KY CD N
Sbjct: 759  AYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHN 818

Query: 409  MPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCD 468
              L  L + +++   E+E++++ K  V +LV +SK IVQLKPR+PD+     I ++A+CD
Sbjct: 819  TSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCD 878

Query: 469  YKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQ 528
            Y+Q +  + K DEC+L+DN++R+KW V  P G + +VPSV  +IPPPN  A++++ ++EQ
Sbjct: 879  YRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQ 938

Query: 529  YYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQ 588
             Y+ ++ALW+QL++N KSL+SW+Y   D++ ++   + KL++    +  + + +L+ HY+
Sbjct: 939  SYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998

Query: 589  EFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQD 648
            +F+++S+ S +F   D+ +++ +    +  +Q L+  +    + +TV    I+       
Sbjct: 999  DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYIS------- 1051

Query: 649  VNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLA----DQGSSHHITV 704
                                  EL+ IR ++E  E R+  +   LA    D+ +     +
Sbjct: 1052 ----------------------ELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNAL 1089

Query: 705  KINELKSVQNDSQAIAEVLNQLKDMLANFR----GSEKYCYLQNEVFGLFQKLENINGVT 760
            +I E +  Q D Q +   L+ +     +F      S     L++E+  L +K++++ G++
Sbjct: 1090 RIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLS 1149

Query: 761  DGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNL 820
              YLN L TV  ++++I   E ++K YE +L++EE V  DL  +EA+   L+   +D+  
Sbjct: 1150 TVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKD 1209

Query: 821  KKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWD 880
            K S+ + +  E+ KA+ +  Q S+  P  +LDL ++ EK +QL +RW R+  Q++ R  +
Sbjct: 1210 KNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSE 1269

Query: 881  LEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGK 940
            LE   + L +YR  +    KW+ +   +Q+ ++  +  DS  +   L++Q  L +EI   
Sbjct: 1270 LESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERN 1329

Query: 941  RDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVH 1000
            + K ++ QK ++  +  +KDYELQL +Y + +E+    P KR  + S S  I QE  D+ 
Sbjct: 1330 QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLR 1389

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKL-----KNTKIEVLEEEL----RLARD----A 1047
             RY  L+T +  + +++S+ L+ LE+ +      K   +E ++E L     LAR+    A
Sbjct: 1390 TRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKA 1449

Query: 1048 NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
             S    ++  +++ + + Q    +   K   + E  + +++    AK        + K++
Sbjct: 1450 TSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI--FLAKHGHKLSEKEKKQI 1507

Query: 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQK--ARQCEKENLGWQKLESEKAIK 1165
            +E++  L           K+  D  D   N   QLQ   A Q E++ L  Q+    + ++
Sbjct: 1508 SEQLNAL----------NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557

Query: 1166 EKEYEIERLRVLL--------QEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLL 1217
            +    + +    L        Q++ +  ++ +++L    + IQ        VV++ E  +
Sbjct: 1558 DLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFM 1617

Query: 1218 VKIKVLEQDKARLQRLEDELNRAKSTLEA---ETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
             + +  +     L  L ++L++AK   EA   ETRV Q+      +++  +     Q + 
Sbjct: 1618 EENQT-KLSPRELTALREKLHQAKEQYEALQEETRVAQK------ELEEAVTSALQQETE 1670

Query: 1275 KEEAIRKIESEREKSEREKN---SLRSEIERLQAEIKRIEERCRRKLEDSTRETQS---- 1327
            K +A +++   ++K +   +   S+ S   +L   +  +E+     LE    +T      
Sbjct: 1671 KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMG 1730

Query: 1328 -QLETERSRYQREIDKLRQRPYGSHRE----TQTECEWTVDTSKLVFDGLRKKVTAMQLY 1382
                 E+   Q E+ K R +   S ++         +  +D          +++   +L 
Sbjct: 1731 VNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLG 1790

Query: 1383 ECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL-- 1440
            E +    T+L +     K V+ +  E+Q FL+            KE  S +E   K+L  
Sbjct: 1791 ELKEQYSTSLAQSEAELKQVQTLQDELQKFLQ----------DHKEFESWLERSEKELEN 1840

Query: 1441 -----ISPESTVMLLEAQAATGGIIDPHRNE 1466
                  SPE+   LL+ Q +    +  H+ +
Sbjct: 1841 MHKGGSSPETLPSLLKRQGSFSEDVISHKGD 1871



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 186/967 (19%), Positives = 376/967 (38%), Gaps = 155/967 (16%)

Query: 415  LEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQK 474
            L+Q++ L+ E +K L+  ++ ++ + +S+K ++   +        P +L+    + +D  
Sbjct: 1807 LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV- 1865

Query: 475  IVHKGDECILKDNNER----SKWYVTG--PGGVDMLVPSVGLIIPPPNPLAVDLSC-KIE 527
            I HKGD   +  + ++       +  G  P  +  LV    L        A+   C ++ 
Sbjct: 1866 ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK-LKDATERYTALHSKCTRLG 1924

Query: 528  QYYEAILALWNQLYINMKSLVSW-HYCMIDIEKIRAMTIAKLKTMRQEDYMKT------I 580
             +   +L  ++Q   +  SL +W   C  ++EK+ + T+A    + QE    T      +
Sbjct: 1925 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 1984

Query: 581  ADLEL---HYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTT 637
            A+ ++     Q+  R+    E     D R +Q        H+Q+L   L    +  ++  
Sbjct: 1985 AEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA---ERSSLLQ 2041

Query: 638  TEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQG 697
              I    + Q+   + +          E   +  L     Q E     M LK   +A Q 
Sbjct: 2042 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQ-EALATNMKLKQ-DIARQK 2099

Query: 698  SSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKL---- 753
            SS   T ++        DS   A +  +L ++   F   E+ C  Q E     +KL    
Sbjct: 2100 SSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRF---EQLCLQQQEKESSLKKLLPQA 2156

Query: 754  ---ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCG 810
               E+++G    ++ +    R L       +D+   ++              +++     
Sbjct: 2157 EMFEHLSGKLQQFMENKS--RMLASGNQPDQDITHFFQ--------------QIQELNLE 2200

Query: 811  LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRI 870
            ++  + +L+  + L+    TEL                + LDL +  ++V  L   +  +
Sbjct: 2201 MEDQQENLDTLEHLV----TELSSCG------------FALDLCQHQDRVQNLRKDFTEL 2244

Query: 871  DKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQ 930
             K +  R  D     +QL  +R   + F KWL + +      E+     +  + + +   
Sbjct: 2245 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM--SAKELEKQIEHL 2302

Query: 931  KNLHSEISGKRDKSEEVQKIAELC-ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPS 989
            K+L  + + K    EE+      C   S+++  +++ +  S  +T   +P   + + S +
Sbjct: 2303 KSLLDDWASKGTLVEEIN-----CKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2357

Query: 990  GV--------ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL-KLKNTKIEVLE-- 1038
            G         I  + +DV+ +Y +L     +    L  +L  +E++ K  N+ ++ LE  
Sbjct: 2358 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2417

Query: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
            EE+  + DA S             +  +A+    KA LA LE              QN  
Sbjct: 2418 EEVLKSMDAMSS--------PTKTETVKAQAESNKAFLAELE--------------QNSP 2455

Query: 1099 KCYGQIKELNEKITRL--TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG-- 1154
            K    I+++ E +  L  TY    E    K +++  + +     ++  ARQ + E     
Sbjct: 2456 K----IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511

Query: 1155 ---WQKLESEKA--IKEKEYEI-----------------ERLRVLLQEEGTRKREYE--N 1190
               +Q  ES+    + EKE  +                 ++++ +L+E   R++++E  N
Sbjct: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 2571

Query: 1191 ELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
            E A+         +  T  VQ         K L+    +   L D+LN   S ++ +  V
Sbjct: 2572 EAAQGILTGPGDVSLSTSQVQ---------KELQSINQKWVELTDKLNSRSSQID-QAIV 2621

Query: 1251 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSER---EKNSLRSEIERLQAEI 1307
            K     + Q++  DL++      ++      I ++ E  ++   E + +RS++E+L  E+
Sbjct: 2622 KST---QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678

Query: 1308 KRIEERC 1314
            K  +  C
Sbjct: 2679 KEAQTLC 2685



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 136/746 (18%), Positives = 280/746 (37%), Gaps = 127/746 (17%)

Query: 709  LKSVQNDSQAIAEVLNQLKDMLANFRGS---EKYCYLQNEVFGLFQKLENINGVTDGYLN 765
            L  ++ +S  I +V   L  +L  +  S   E +  +Q E+   +++   +       L 
Sbjct: 2447 LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLE 2506

Query: 766  SLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 825
               +  A  QA    E  L+ +   L E+E +   L         L    N LN +K  +
Sbjct: 2507 ESASHLACFQA---AESQLRPW---LMEKELMMGVLGP-------LSIDPNMLNAQKQQV 2553

Query: 826  ATMKTELQKAQQIHSQTSQQYPLY-------DLDLGKFGEKVTQLTDRWQRIDKQIDFRL 878
              M  E +  +Q H Q ++             L   +  +++  +  +W  +  +++ R 
Sbjct: 2554 QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRS 2613

Query: 879  WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
              +++ I +   Y++  Q   + +    +R  S++S        V + L E   + S++ 
Sbjct: 2614 SQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-SVQSAISTQPEAVKQQLEETSEIRSDLE 2672

Query: 939  GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
                + +E Q + +  +  I +  L+       LET          +  P   +   AAD
Sbjct: 2673 QLDHEVKEAQTLCDELSVLIGEQYLK-DELKKRLET----------VALPLQGLEDLAAD 2721

Query: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL 1058
               R    L  +  + +   E+   L+D + +  K   +  +L   +    EN    K L
Sbjct: 2722 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSL 2781

Query: 1059 DQNLQKYQAECSQFKAKLAS-------------LEELKRQ-AELDGKSAKQN-------- 1096
            +Q+   Y+   ++ ++ L S             L ELK    EL  K+A +         
Sbjct: 2782 NQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ 2841

Query: 1097 ---------------LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQ 1141
                           ++ C  ++ EL  ++T    ++E    R K++ +  +++++  + 
Sbjct: 2842 KAQKYQWHVEDLVPWIEDCKAKMSEL--RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEI 2899

Query: 1142 LQKAR-------QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194
            L  A        + +++ +  +K    + +     E++     L+E   R RE++     
Sbjct: 2900 LNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKN 2959

Query: 1195 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR---LQRLEDE--------------- 1236
               +++ +K+Q  ++     S     K LE+ +A+   LQ LE +               
Sbjct: 2960 IEKKVEGAKHQL-EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA 3018

Query: 1237 ---------LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1287
                     L++A+   +    VKQR+      ++N L      + R  E   ++    +
Sbjct: 3019 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3078

Query: 1288 KSE------REKNSLRSEIER----------LQAEIKRIEERCRRKLEDSTRETQSQLET 1331
            + +      R+ +SL+S+IE           L+ +I+  E  CR  LE+        L+ 
Sbjct: 3079 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKR 3138

Query: 1332 ERSRYQREIDKLRQRPYGSHRETQTE 1357
            E     ++  KL +R  G  R+ Q E
Sbjct: 3139 ELEALNKQCGKLTER--GKARQEQLE 3162



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 113/609 (18%), Positives = 251/609 (41%), Gaps = 84/609 (13%)

Query: 738  KYCYLQNEVFGLFQKLENINGVTDGYLNSLC-----TVRALLQAILQT-EDMLKVYEARL 791
            K+  L+N+V      +E +N   +  L S       ++R+ L+A+ Q  E +L+  E R 
Sbjct: 4307 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4366

Query: 792  TEEETVCLDLD----KVEAYRCGLKKIKNDLNLKK---SLLATMKTELQKAQQIHSQTSQ 844
             + ++          ++E +   L ++++ L+  K    L  T + +L    +++SQ   
Sbjct: 4367 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKA 4426

Query: 845  QYPLYD--LDLGKF----------GEKVTQ----LTDRWQRIDKQIDFRLWDLEKQIKQL 888
            +   Y+  LD G+           G K  Q    L  +W  +  +++ R   LE+ +   
Sbjct: 4427 KEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLA 4486

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
              ++++ Q F  WL  A++   ++ S      NTV+  + E K   +E++  RD+  E+ 
Sbjct: 4487 TEFQNSLQEFINWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
            +            +L+  S    +  + N+ +    +QS    ++Q + +      +   
Sbjct: 4546 QTGN---------QLKFLSQKQDVVLIKNLLVS---VQSRWEKVVQRSIERGRSLDDARK 4593

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN--SENCNKNKFLDQNLQKYQ 1066
            R+  ++    +++  LED +        L+ EL ++ D +      +K+K   + L   Q
Sbjct: 4594 RAKQFHEAWKKLIDWLEDAE------SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQ 4647

Query: 1067 AECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK 1126
                 +   + +   LK +  L   S  Q LD   G++++  + +   + E      R+ 
Sbjct: 4648 ---PVYDTTIRTGRALKEKTLLPEDS--QKLDNFLGEVRDKWDTVCGKSVE------RQH 4696

Query: 1127 SVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAIKEKEYEIERLRVLLQEEGTRK 1185
             +E+         D LQ         + W  K+E + A  +  +    L + L +     
Sbjct: 4697 KLEEALLFSGQFMDALQAL-------VDWLYKVEPQLAEDQPVHGDLDLVMNLMD---AH 4746

Query: 1186 REYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNR-AKSTL 1244
            + ++ EL K +  +Q  K    ++++        +      K +LQ L    +   K ++
Sbjct: 4747 KVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV------KGQLQELSTRWDTVCKLSV 4800

Query: 1245 EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ 1304
              ++R++Q L+ + +  ++ ++      S  E+ +R     R     +  +L+S I+  +
Sbjct: 4801 SKQSRLEQALK-QAEVFRDTVHMLLEWLSEAEQTLR----FRGALPDDTEALQSLIDTHK 4855

Query: 1305 AEIKRIEER 1313
              +K++EE+
Sbjct: 4856 EFMKKVEEK 4864



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 116/579 (20%), Positives = 238/579 (41%), Gaps = 51/579 (8%)

Query: 858  EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            + + ++ + W+ ++K    RL  LE  ++    Y+D  QA   WL +   +  ++  +  
Sbjct: 4127 KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG- 4185

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC---ANSIKDYELQLASYTSGLET 974
             D NTV   LNE K    E+  ++ + E++    EL    A    D ++     T     
Sbjct: 4186 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHL 4245

Query: 975  LLNIPIKRTMIQSP-SGVILQEAADVHA--RYIELLTRSGDYYRFLSEMLKSLEDLKLKN 1031
              N+  K    Q    G +L      HA    +  LT + +       +    + ++++ 
Sbjct: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVEL 4305

Query: 1032 TKIEVLEEELRLARDANSENCNK--NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
             K  VL+ ++ LA  A  E  NK  N+ L+ +      + S  +++L ++ +        
Sbjct: 4306 AKHHVLKNDV-LAHQATVETVNKAGNELLESSAGD---DASSLRSRLEAMNQC------- 4354

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
             +S  Q  ++   Q++   ++      EIED       +E +    K      + AR+  
Sbjct: 4355 WESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL 4414

Query: 1150 KENLGWQKLESEKAIKEKEY----EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQ 1205
              ++   +L S+   KE+ Y    +  RL +L +++     + E  +A     +++  + 
Sbjct: 4415 DTHM---ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA----LLEQKWHV 4467

Query: 1206 CTQVVQERESLLVK-IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQ-- 1262
             +  ++ER+S L + + +  + +  LQ   + L  A+ +L   +     L     QI+  
Sbjct: 4468 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEH 4527

Query: 1263 ----NDLNQWKTQYSRKEEAIRKIE--SEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1316
                N++N  + Q    ++   +++  S+++     KN L S   R +  ++R  ER  R
Sbjct: 4528 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER-GR 4586

Query: 1317 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
             L+D+ +  +   E     +++ ID L      +     +E E + D  K+     + K 
Sbjct: 4587 SLDDARKRAKQFHEA----WKKLIDWLED----AESHLDSELEISNDPDKIKLQLSKHKE 4638

Query: 1377 TAMQLYECQLIDKTTL--DKLLKGKKSVEEVASEIQPFL 1413
                L   Q +  TT+   + LK K  + E + ++  FL
Sbjct: 4639 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 4677



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 106/513 (20%), Positives = 197/513 (38%), Gaps = 81/513 (15%)

Query: 801  LDKVEAYRCGLKKIKNDLNLKKSLLATMK---TELQKAQQIHSQTSQQYPLY------DL 851
            LD      C +  +  DLN  K  L  MK    E+ + Q    + + Q  L       + 
Sbjct: 4171 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4230

Query: 852  DLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS 911
            D     E +T+L   W+ + ++I  R   LE  +  L  ++   +    WL   +   D+
Sbjct: 4231 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4290

Query: 912  LESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIA-ELCANSIKDYELQLASYTS 970
               +  GD   +   L +   L +++   +   E V K   EL  +S  D    L S   
Sbjct: 4291 QRPIS-GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4349

Query: 971  GLETLLNIPIKRT-----MIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLE 1025
             +       +++T      +QS     LQ+A   H+                      +E
Sbjct: 4350 AMNQCWESVLQKTEEREQQLQS----TLQQAQGFHS---------------------EIE 4384

Query: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEEL--K 1083
            D  L+ T+   +E +L  ++          + LD +++ Y    SQ KAK  +  +L  K
Sbjct: 4385 DFLLELTR---MESQLSASKPTGGLPETAREQLDTHMELY----SQLKAKEETYNQLLDK 4437

Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
             +  L  +    +  K    +  L +K   ++ ++E+ K        + ++  N   + Q
Sbjct: 4438 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK-------SKLEEALNLATEFQ 4490

Query: 1144 KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI---Q 1200
             + Q   E + W  L  +         +    VL Q E    + + NE+    ++I    
Sbjct: 4491 NSLQ---EFINWLTLAEQSLNIASPPSLILNTVLSQIE--EHKVFANEVNAHRDQIIELD 4545

Query: 1201 ESKNQCTQVVQERESLLVK----------IKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
            ++ NQ   + Q+++ +L+K           KV+++   R + L+D   RAK   EA  ++
Sbjct: 4546 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 4605

Query: 1251 KQRLECEKQ------QIQNDLNQWKTQYSRKEE 1277
               LE  +       +I ND ++ K Q S+ +E
Sbjct: 4606 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 4638



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 113/627 (18%), Positives = 238/627 (37%), Gaps = 78/627 (12%)

Query: 850  DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
            D D+      + ++  RW  ++K++  R+  L++ +     ++D  +    WL D +   
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300

Query: 910  DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969
             + +     +   V   + EQK L   +  ++   + +Q      A S      +LA   
Sbjct: 3301 AN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS-----AELADRE 3354

Query: 970  SGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL 1029
                 L ++  + T + S +    ++  D+     +    +     FLS   K L + + 
Sbjct: 3355 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3414

Query: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
              T+   +++++            ++K L+++++ +  +  Q      SL  L   AE  
Sbjct: 3415 VGTQTAKIQQQI-----------IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-- 3461

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR--- 1146
                        G + E  + +     EI+D   R+ ++ D+          L  AR   
Sbjct: 3462 -----------QGVLSEKIDSLQARYSEIQDRCCRKAALLDQ---------ALSNARLFG 3501

Query: 1147 QCEKENLGWQKLESEK--AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
            + E E L W     +K  ++  K+++ + L     +      E  N        I+  + 
Sbjct: 3502 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 3561

Query: 1205 QCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1264
               Q   E E LL++ K L+  K R   +    ++A  TLE   ++  + +   +++   
Sbjct: 3562 LLKQTTGE-EVLLIQEK-LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 3619

Query: 1265 LNQWKTQ------YSRKEEAIRKIESEREKSEREKNSLR------SEIERLQAEIK--RI 1310
            L + + +       S   E I + +  +++ ++E    R      +E+ R   E+   R 
Sbjct: 3620 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA 3679

Query: 1311 EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTS-KLVF 1369
             E   + + D+  + +   +T   R   EID   QR     +    E  W  +T  KL+ 
Sbjct: 3680 REGLDKLVSDANEQYKLVSDTIGQRVD-EIDAAIQRSQQYEQAADAELAWVAETKRKLMA 3738

Query: 1370 DG---LRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASP 1426
             G   L +  T  QL     + K     +++ K S++E+ S         G         
Sbjct: 3739 LGPIRLEQDQTTAQLQ----VQKAFSIDIIRHKDSMDELFSHRSEIFGTCG--------- 3785

Query: 1427 KEKYSLVEAKRKKLISPESTVMLLEAQ 1453
            +E+ ++++ K + LI     + LL ++
Sbjct: 3786 EEQKTVLQEKTESLIQQYEAISLLNSE 3812



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 93/522 (17%)

Query: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918
            ++ +L + W+ + K+   R   L+  +++ + Y+ + +    W+ D K +   L      
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-- 2871

Query: 919  DSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNI 978
            D   +   L   K + +E+  +R   E +   A++  NS +  E  +    +G+      
Sbjct: 2872 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGIN----- 2926

Query: 979  PIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLE 1038
                               ++ A   EL  ++G        + +  E  K    K+E  +
Sbjct: 2927 ------------------QNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 2968

Query: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR------QAELDGKS 1092
             +L +     S+ C+     ++NL+K +A+    +A    ++ L+       +   DG  
Sbjct: 2969 HQLEIFDALGSQACS-----NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSD 3023

Query: 1093 AKQNLDKC------YGQIKE-LNEKITRLTYEIEDEKRRRKSVEDRFDQQKN-------- 1137
            A Q L +       + ++K+ +N     +  ++E   +    V + F Q  +        
Sbjct: 3024 ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3083

Query: 1138 -----DYDQLQKARQCEKENLGWQKLESEKA-IKEKEYEIERLRVLLQEEGTRKREYENE 1191
                 D D LQ   Q E   L   K+   K  I+  E E    R +L+EEGT       +
Sbjct: 3084 GAIGRDTDSLQS--QIEDVRLFLNKIHVLKLDIEASEAE---CRHMLEEEGTL------D 3132

Query: 1192 LAKASNRIQESKNQCTQVVQ----ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1247
            L      ++    QC ++ +     +E L + +  +E    +L+ L D    A+     +
Sbjct: 3133 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3192

Query: 1248 TRVKQRLECEKQQIQ--------------------NDLNQWKTQYSRKEEAIRKIESERE 1287
              V   +E   QQ+                     N L Q   Q + K+  ++ +E + E
Sbjct: 3193 WVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME 3252

Query: 1288 KSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1329
            +     N+L  ++ +  A+++     C  K +D+     S L
Sbjct: 3253 EINARWNTLNKKVAQRIAQLQEALLHC-GKFQDALEPLLSWL 3293



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 171/973 (17%), Positives = 350/973 (35%), Gaps = 175/973 (17%)

Query: 574  EDYMKTIADLELH---YQEFIRNSQGS-----EMFGDDDKRKIQSQFTDAQKHYQTLVIQ 625
            + Y   + D EL    Y+ F+ + Q S      M    D   I  +F D +  Y  LV  
Sbjct: 1341 QQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDA--ITQEFMDLRTRYTALVTL 1398

Query: 626  LPGYPQHQTVTTTEITHHGTCQDVNHNKVIE---------------TNRENDKQETWMLM 670
               + ++ +     +       +    + +E               T  +    ET    
Sbjct: 1399 TTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKEST 1458

Query: 671  ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDML 730
            +++K   + +     +T K   +++   +  I +  +  K  + + + I+E LN L    
Sbjct: 1459 DIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAY 1518

Query: 731  ANF--RGSEKYCYLQNEVFGLFQK--LENINGVTDGYLNSLCTVRALLQAILQTEDMLKV 786
             +     + +   LQ+++    ++  L+         L  LC+       + Q E  L  
Sbjct: 1519 HDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW------VGQAERALAG 1572

Query: 787  YEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQY 846
            ++ R T++     DL  ++  +  LK +++D+  + +  AT+  +++   +       Q 
Sbjct: 1573 HQGRTTQQ-----DLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFME-----ENQT 1622

Query: 847  PLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAK 906
             L   +L    EK+ Q  ++++ + ++      +LE+ +              K L + K
Sbjct: 1623 KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENK 1682

Query: 907  RRQDSLESMKFGDSNTVMRFLN-----EQKNLHSEISGKRDKSEEVQKIAELCANSIKDY 961
            ++ D+L        ++  + L      EQ +  S   G  D ++    + +      K  
Sbjct: 1683 KKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQC 1742

Query: 962  ELQLASYTSGLETLLNIPIKRTMIQS------------PSGVILQEAADVHARYIELLTR 1009
            E+  A +   L    N  +     Q+               ++ Q+  ++  +Y   L +
Sbjct: 1743 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQ 1802

Query: 1010 SGDYYRFLS----EMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKY 1065
            S    + +     E+ K L+D K   + +E  E+EL        EN +K     + L   
Sbjct: 1803 SEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL--------ENMHKGGSSPETLPSL 1854

Query: 1066 QAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRR 1125
                  F   + S +   R   + G+    +++  + + KE +E    +  +++D   R 
Sbjct: 1855 LKRQGSFSEDVISHKGDLRFVTISGQKVL-DMENSFKEGKEPSEIGNLVKDKLKDATERY 1913

Query: 1126 KSVEDR--------------FDQQKNDYDQLQKARQ-CE------------------KEN 1152
             ++  +              + Q +N  D LQ   Q CE                  +E 
Sbjct: 1914 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 1973

Query: 1153 LGWQKLESEKAIKEKEYEIERL----RVLLQEEGTRKREYEN-----------------E 1191
            L   K + ++ + E +  +E+L    R +++ EG    ++ +                  
Sbjct: 1974 LATTK-QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYS 2032

Query: 1192 LAKASNRIQESKNQCTQVVQERESLLVKIKVLEQD-----------------KARLQRLE 1234
            LA+ S+ +Q++  Q   V +  ESLL  I  +EQ+                  A   +L+
Sbjct: 2033 LAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLK 2092

Query: 1235 DELNRAKSTLEAETRVKQR-LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK 1293
             ++ R KS+LEA   +  R +E         L     + S++ E +   + E+E S ++ 
Sbjct: 2093 QDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2152

Query: 1294 NSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ---------SQLETERSRYQREIDKLR 1344
                   E L  ++++  E   R L    +  Q          +L  E    Q  +D L 
Sbjct: 2153 LPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL- 2211

Query: 1345 QRPYGSHRETQ-TECEWTVDTSKLV--FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKS 1401
                  H  T+ + C + +D  +       LRK  T +Q          T+ +  K   S
Sbjct: 2212 -----EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQ---------KTVKEREKDASS 2257

Query: 1402 VEEVASEIQPFLR 1414
             +E   E +  +R
Sbjct: 2258 CQEQLDEFRKLVR 2270



 Score = 39.7 bits (91), Expect = 0.034
 Identities = 28/68 (41%), Positives = 36/68 (52%), Gaps = 4/68 (5%)

Query: 2208 SVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGS----FDATGNSSYSYSY 2263
            S SS    +    + A   +S SR GSR+GSR+GSR+ SRRGS    FD     S     
Sbjct: 5330 SNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDT 5389

Query: 2264 SFSSSSIG 2271
            S SS++ G
Sbjct: 5390 SESSAAGG 5397



 Score = 32.3 bits (72), Expect = 5.4
 Identities = 34/168 (20%), Positives = 70/168 (41%), Gaps = 14/168 (8%)

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            LQA++   D L   E +L E++ V  DLD V       K  + +L  +   +  +K   +
Sbjct: 4712 LQALV---DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK---R 4765

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
              +++   +         D      ++ +L+ RW  + K    +   LE+ +KQ   +RD
Sbjct: 4766 SGRELIENSRD-------DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRD 4818

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
                  +WL +A++      ++   D+  +   ++  K    ++  KR
Sbjct: 4819 TVHMLLEWLSEAEQTLRFRGALP-DDTEALQSLIDTHKEFMKKVEEKR 4865


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  460 bits (1183), Expect = e-129
 Identities = 262/862 (30%), Positives = 475/862 (55%), Gaps = 57/862 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 541  CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 657

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI +++ ++++ ++D  + S 
Sbjct: 658  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSP 717

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 718  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 777

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 778  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 837

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+K  CD++  +  L + +
Sbjct: 838  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLL 897

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 898  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 957

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN    +   ++E  ++A++ LW+
Sbjct: 958  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWH 1017

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 1018 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1077

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 1078 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1117

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 1118 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1167

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1168 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1227

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1228 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1287

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1288 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1347

Query: 894  NYQAFCKWLYDAKRRQDSLESM 915
            +      WL DA+RRQ+ +++M
Sbjct: 1348 SADPLGAWLQDARRRQEQIQAM 1369



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 66/341 (19%), Positives = 133/341 (39%), Gaps = 51/341 (14%)

Query: 867  WQRIDKQIDF-RLWDL--------EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            WQ + + +   R W L        E+Q + L +   +YQAF +         DS ++  F
Sbjct: 1029 WQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLR---------DSQDAGGF 1079

Query: 918  GDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETL 975
            G  + +M  R      + + ++    ++  + +   + C + +KD  LQL +  +     
Sbjct: 1080 GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR 1139

Query: 976  LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIE 1035
            L +P+ +     P+    Q  A+      E+        R  +E  K L  L   +    
Sbjct: 1140 LRLPLDK----EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAP 1194

Query: 1036 VLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ 1095
             L  EL L                  L++ ++  + +  KL ++  + R  +     A++
Sbjct: 1195 TLRSELELTLG--------------KLEQVRSLSAIYLEKLKTISLVIRGTQ----GAEE 1236

Query: 1096 NLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL-------QKARQC 1148
             L     Q+KE  + +     E+E  K   K +  + + Q+  +D L       Q+  + 
Sbjct: 1237 VLRAHEEQLKEA-QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1295

Query: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYE 1189
             ++  G + +E E+  +     +ER + +L +   R+RE E
Sbjct: 1296 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1336


>gi|207452735 epiplakin 1 [Homo sapiens]
          Length = 5090

 Score =  382 bits (981), Expect = e-105
 Identities = 283/872 (32%), Positives = 439/872 (50%), Gaps = 91/872 (10%)

Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGS 1418
            ++ V DGL       +L E Q+     +D L   + SVE+      V  E+   L  A  
Sbjct: 1263 AQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAER 1322

Query: 1419 IAGASASP--KEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
             A     P  +   SL +A  K L+     + LL+ Q ATGG++DP     L   +A   
Sbjct: 1323 AAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRL 1382

Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
             L+D    Q + A +K    F DP +   V+  +  ++ + D ETG+ LL     +   V
Sbjct: 1383 GLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEV 1442

Query: 1537 DPVNSVFL-----PKDVALARGLIDR--DLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE 1589
            D   +V L     P      +G      DL  S     D ++  V      + + ++   
Sbjct: 1443 DDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALR--- 1499

Query: 1590 RCRIEPHTGLLLLSVQKRSM--SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEV 1647
              ++      L+ + +++ +  +F+G+R+ V+  +L  + ++   T++EL  G  +  EV
Sbjct: 1500 --QVVSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEV 1557

Query: 1648 GER--IKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDP 1705
             E   +K  L+G + IAG+  + T++++ I EA++  ++RPGTAL LLEAQAATGFI+DP
Sbjct: 1558 AEMDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDP 1617

Query: 1706 VSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 1765
              N +L VEEA+K G+ G E   KLLSAERAVTGY DP TG  ISLFQAM K+LI + HG
Sbjct: 1618 AENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHG 1677

Query: 1766 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENL 1825
            IRLLEAQIATGGIIDP  SHR+PVD+AY+ GYF+EE++ IL+DPSDDTKGFFDPNT ENL
Sbjct: 1678 IRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENL 1737

Query: 1826 TYLQLKERCIKDEETGLCLLPLKEKKKQ---VQTSQKNTLRKRRVVIVDPETNKEMSVQE 1882
            TYLQL ERC++D ETGL LL + +K +    +  + ++ L+ R           +M V  
Sbjct: 1738 TYLQLLERCVEDPETGLYLLQIIKKGENYVYINEATRHVLQSR---------TAKMRVGR 1788

Query: 1883 AYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDR 1942
             +   ++ +            W+ +       S+     DRK                 R
Sbjct: 1789 -FADQVVSF------------WDLL-------SSPYFTEDRK-----------------R 1811

Query: 1943 KFFDQYRSGSLSLTQFADMISL--------KNGVGTSSSMGSGVSDDVFSSSRHESVSKI 1994
            +   +Y + S  L +  ++I+           G+  ++  G   + D+F+S     V   
Sbjct: 1812 ELIQEYGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNS----RVIDQ 1867

Query: 1995 STISSVRNLTIRSSSFSDT------LEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2048
             T+ ++R       + S        LE S  IA +      E +S+ E   + ++ +   
Sbjct: 1868 KTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927

Query: 2049 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKM 2108
              LLEAQA TG ++ P T QKLS+ +AV  G++++++  RL  A++A  G+        +
Sbjct: 1928 TWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTI 1987

Query: 2109 SAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDT 2168
               +A++++ +      R LE Q  TGG++DP+ H R+  E A R+G +       + D 
Sbjct: 1988 PLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQ 2047

Query: 2169 SSYAKILTCPKTKLKISYKDAINRSMVEDITG 2200
                K    P T+ K+SY++   R   ++ TG
Sbjct: 2048 KHMRKRFVDPNTQEKVSYRELQERCRPQEDTG 2079



 Score =  372 bits (955), Expect = e-102
 Identities = 287/963 (29%), Positives = 449/963 (46%), Gaps = 149/963 (15%)

Query: 1335 RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDK 1394
            RY++    L Q       ETQ + +       ++   LR +VT  QL E  +ID+  LD+
Sbjct: 853  RYRQREVTLGQVAKLLEAETQRQAD-------IMLPALRSRVTVHQLLEAGIIDQQLLDQ 905

Query: 1395 LLKGKKSVEEVA--SEIQPFLRGAGSIAGASASPK-EKYSLVEAKRKKLISPESTVMLLE 1451
            +L G  S E +     ++ +L G G++ G    P  ++ SL +A R+KL+ P   + LLE
Sbjct: 906  VLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLE 965

Query: 1452 AQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEA 1511
            AQAATG I+DPH  E L+VD A+ R ++  +   ++  AE AI GF DPFSGK VSV +A
Sbjct: 966  AQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQA 1025

Query: 1512 IKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQK 1571
            +KK LI  E   RLLEAQ+A+GG++DP +   LP  VA+ RG +D+++  +L+    S +
Sbjct: 1026 MKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALS---SSSE 1082

Query: 1572 NFVDPVTKKKVSYVQLKERCRIEPHTGLLLL-------------SVQKRSMSFQGIRQPV 1618
             F  P  + + SY QL E C  +  +GL LL              VQ+   +  G +   
Sbjct: 1083 TFPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPGAKDGT 1142

Query: 1619 TVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCI------------- 1661
            ++ +L+ S       R   + +++ G+ +  ++   ++ ++Q +  +             
Sbjct: 1143 SLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGE 1202

Query: 1662 --------AGIYNETTKQKL--------------------------------------GI 1675
                    AGI  + T + L                                       I
Sbjct: 1203 VPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASI 1262

Query: 1676 YEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAER 1735
             +A++ GL+  G    LLEAQ A+GF+VDP++N RL VE+A K GLVG E  E+L  AER
Sbjct: 1263 AQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAER 1322

Query: 1736 AVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKR 1795
            A  GY DP +   +SL+QAM K L+ +  G+ LL+ Q+ATGG++DP     LP   A + 
Sbjct: 1323 AAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRL 1382

Query: 1796 GYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL-KEKKKQV 1854
            G  + + S++L+    D K FFDP+  + +TY QL+ERC+ D ETGL LLPL  +   +V
Sbjct: 1383 GLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEV 1442

Query: 1855 QTSQKNTLRKRRV-VIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSD 1913
                   LR  +V V         +S+ +      +  +  +EL    C           
Sbjct: 1443 DDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVAL-CRSGRAAALRQV 1501

Query: 1914 GSTRVVLVD-----------RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 1962
             S    LV+           R    Q   +D     L+ RK  D+   G+ ++ + A+M 
Sbjct: 1502 VSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMD 1561

Query: 1963 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2022
            S+K                                               +LE  + IA 
Sbjct: 1562 SVKR----------------------------------------------SLEGGNFIAG 1575

Query: 2023 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2082
            +      E++SI E + R I+   T   LLEAQA TG II P   +KL++++A   G+  
Sbjct: 1576 VLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFG 1635

Query: 2083 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2142
            ++   +L  A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP  
Sbjct: 1636 KETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVH 1695

Query: 2143 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2202
              R+  + A R G+ D    + L D S   K    P T   ++Y   + R + +  TGL 
Sbjct: 1696 SHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLY 1755

Query: 2203 LLE 2205
            LL+
Sbjct: 1756 LLQ 1758



 Score =  345 bits (885), Expect = 3e-94
 Identities = 253/814 (31%), Positives = 406/814 (49%), Gaps = 68/814 (8%)

Query: 1416 AGSIAGASASPK-EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAI 1474
            A SIAG       +  S+  A  + L+       LLEAQAATGG++D  R + L V  A+
Sbjct: 40   ARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKAL 99

Query: 1475 ARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGG 1534
             + L+  + ++++ AAE+A TG+ DP+ G+ +++ +AI K ++DR  G   LE Q+A+GG
Sbjct: 100  QQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGG 159

Query: 1535 VVDPVNSVFLPKDVALARGLIDRDLYRSLND--PRDSQKNFVDPVTKKKVSYVQLKERCR 1592
            +VDP   V +  + A  +GL+DR+ +  L++  P      F++P T ++++Y QL ERC 
Sbjct: 160  LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERCV 219

Query: 1593 IEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER-- 1650
              P +GL LL ++   ++F+ +   V+  EL++ GIL    V  L  G+++  +V  R  
Sbjct: 220  RAPGSGLALLPLK---ITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAE 276

Query: 1651 IKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLR 1710
            ++ +L+G+  +AG+       K   ++A    L+  GTAL LLEAQAAT  +VDP++  R
Sbjct: 277  VRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQR 336

Query: 1711 LPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLE 1770
            L V+EA + GLV  E  E+LL AE+AVTG++DP +G+ I LFQAM K L+++   +RLL+
Sbjct: 337  LWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLD 396

Query: 1771 AQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQL 1830
            AQ+ATGG++ P    RLP++ A + G  +E+    LS       G F   T   L Y QL
Sbjct: 397  AQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQ-----AGSFSDGTHGGLRYEQL 451

Query: 1831 KERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLID 1890
               C+ D ETGL  LPL    +  +      ++               S ++A       
Sbjct: 452  LALCVTDPETGLAFLPLSGGPRGGEPQGPPFIK--------------YSTRQALSTATAT 497

Query: 1891 YETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRS 1950
                K        WE +         R +L                          QY+ 
Sbjct: 498  VSVGKFRGRPVSLWELLFSEAISSEQRAMLA------------------------QQYQE 533

Query: 1951 GSLSLTQFADMIS--LKNGVGTSSSMGSGVSD----------DVFSSSRHESVSK-ISTI 1997
            G+LS+ + A  +S  L+    T+    SG+ D          ++     +E +    +T 
Sbjct: 534  GTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATA 593

Query: 1998 SSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQAC 2057
              V +L    +S    L+ +  IA +    + E++SI E   +G++   T   LLEAQA 
Sbjct: 594  KDVGSL----ASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAA 649

Query: 2058 TGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEK 2117
            TG II P   +  S+++A+   VI  D+  +L  A++A  G+      +++S  +A+++ 
Sbjct: 650  TGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKG 709

Query: 2118 WLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTC 2177
             +  E G R LE Q  TGG++DP    R+  + A R+G+ D      L D S   K    
Sbjct: 710  LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFD 769

Query: 2178 PKTKLKISYKDAINRSMVEDITGLRLLEAASVSS 2211
            P T   ++Y   + R + +  TGL LL  +S  S
Sbjct: 770  PNTHENLTYLQLLERCVRDPETGLYLLPLSSTQS 803



 Score =  339 bits (870), Expect = 2e-92
 Identities = 286/963 (29%), Positives = 445/963 (46%), Gaps = 159/963 (16%)

Query: 1366 KLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGAS 1423
            K+ F  +   V+A +L E  ++D+  +  L +G+ +  +V++  E++ +L G GS+AG  
Sbjct: 232  KITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVV 291

Query: 1424 ASPK-EKYSLVEAKRKKLISPESTVMLLEAQAAT-------------------GGIIDPH 1463
              P+  K S  +A  + L+   + + LLEAQAAT                    G++ P 
Sbjct: 292  LLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPE 351

Query: 1464 RNEKLTVDS-------------------AIARDLIDFDDRQQIYAAEKAITGFDDPFSGK 1504
             +E+L V                     A+ + L+D     ++  A+ A  G   P    
Sbjct: 352  LHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRL 411

Query: 1505 TVSVSEAIKKNLIDRETGMRLLEAQIASGG--------------VVDPVNSV-FLPKDVA 1549
             + +  A++   +D +T  +L +A   S G              V DP   + FLP    
Sbjct: 412  RLPLEAALRCGCLDEDTQRQLSQAGSFSDGTHGGLRYEQLLALCVTDPETGLAFLPLSGG 471

Query: 1550 LARG---------LIDRDLYRSLNDPRDSQKNFVDPVTKKKVSY---VQLKERCRIEPHT 1597
               G            R    +        K    PV+  ++ +   +  ++R  +    
Sbjct: 472  PRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAISSEQRAMLAQQY 531

Query: 1598 GLLLLSVQKRS---------------MSFQGIRQPVTVTELVDSGILRPSTVNELESGQI 1642
                LSV+K +               ++F G+R  VT  EL+ + I+       LE GQ 
Sbjct: 532  QEGTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQA 591

Query: 1643 SYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATG 1700
            +  +VG     + +LQG+ CIAG+    ++++L IYEA   GL+RPGTAL LLEAQAATG
Sbjct: 592  TAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATG 651

Query: 1701 FIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELI 1760
            FI+DP +N    VEEA +  ++G +   KLLSAERAVTGY DP TG  ISLFQAM K LI
Sbjct: 652  FIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLI 711

Query: 1761 EKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPN 1820
             + HGIRLLEAQIATGG+IDP  SHR+PVD+AY+RGYF++ L+ IL DPSDDTKGFFDPN
Sbjct: 712  VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPN 771

Query: 1821 TEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSV 1880
            T ENLTYLQL ERC++D ETGL LLPL   +  +  S      +  ++ V          
Sbjct: 772  THENLTYLQLLERCVRDPETGLYLLPLSSTQSPLVDSATQQAFQNLLLSV---KYGRFQG 828

Query: 1881 QEAYKKGLIDYETFKELCEQEC----EWEEITITGSDGSTRVVLVDRKTGSQYDI----- 1931
            Q      LI+ E F E   ++        E+T+          L++ +T  Q DI     
Sbjct: 829  QRVSAWELINSEYFSEGRRRQLLRRYRQREVTL-----GQVAKLLEAETQRQADIMLPAL 883

Query: 1932 ------QDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK------NGVGTSSSMGSGVS 1979
                     ++ G++D++  DQ  +G++S      M  ++        VG    + SG  
Sbjct: 884  RSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQR 943

Query: 1980 DDVFSSSRHE------------------------SVSKISTISSVRNLTIRSSSFSDTLE 2015
              ++ + R +                        S   +S   +VR   +    +     
Sbjct: 944  LSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKR 1003

Query: 2016 ESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDA 2075
                IA   D  + +++S+ + +++G++      RLLEAQ  TGGII PT+   L +  A
Sbjct: 1004 AEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVA 1063

Query: 2076 VSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTG 2135
            + +G +DQ+M T L  + +    F    G+ + S A+ ++E      +G   L       
Sbjct: 1064 IQRGYVDQEMETALSSSSET---FPTPDGQGRTSYAQLLEECPRDETSGLHLLPL----- 1115

Query: 2136 GLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMV 2195
                PE    + TEE +++     +A    +D +S   +L+         + +   R ++
Sbjct: 1116 ----PESAPALPTEEQVQRSL---QAVPGAKDGTSLWDLLS------SCHFTEEQRRGLL 1162

Query: 2196 EDI 2198
            ED+
Sbjct: 1163 EDV 1165



 Score =  339 bits (869), Expect = 2e-92
 Identities = 270/941 (28%), Positives = 430/941 (45%), Gaps = 137/941 (14%)

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGASAS- 1425
            F GLRK+V+A  L+  QLI + TLD+L +G  +V+EVA    ++  L G   IAG     
Sbjct: 1521 FRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVLIQG 1580

Query: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDS------------- 1472
             +E+ S+ EA R+ ++ P + ++LLEAQAATG IIDP  N KLTV+              
Sbjct: 1581 TQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYV 1640

Query: 1473 -------------------------AIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVS 1507
                                     A+ +DLI  +   ++  A+ A  G  DP     V 
Sbjct: 1641 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVP 1700

Query: 1508 VSEAIK-------------------KNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDV 1548
            V  A +                   K   D  T   L   Q+    V DP   ++L + +
Sbjct: 1701 VDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQII 1760

Query: 1549 -----------ALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCR----- 1592
                       A    L  R     +    D   +F D ++    +  + +E  +     
Sbjct: 1761 KKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTEDRKRELIQEYGAQ 1820

Query: 1593 ---IEPHTGLLLLSVQKRSMSFQGI-----RQPVTVTELVDSGILRPSTVNELESGQISY 1644
               +E    ++  ++++     QGI     R  VT  +L +S ++   T++ L  G+   
Sbjct: 1821 SGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQKTLHTLRVGRTGG 1880

Query: 1645 DEVG--ERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFI 1702
              +   E +K +L+GS CIAG+   +T++ + ++EA +  L+    A  LLEAQAATGF+
Sbjct: 1881 QALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFL 1940

Query: 1703 VDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEK 1762
            +DP +  +L V+EA   GLV  E +E+LL AERA TGY DP TG+ I LFQAM K+LIEK
Sbjct: 1941 LDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEK 2000

Query: 1763 GHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTE 1822
               +RLLE Q+ATGG+IDP+  HRLP++ AY+RG  ++++  ++SD     K F DPNT+
Sbjct: 2001 AEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQ 2060

Query: 1823 ENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQE 1882
            E ++Y +L+ERC   E+TG  L P+ +  +  +              +D ET + +    
Sbjct: 2061 EKVSYRELQERCRPQEDTGWVLFPVNKAARDSEH-------------IDDETRRAL---- 2103

Query: 1883 AYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDR 1942
                              E E  EIT+    G    +       S+Y  ++   K  + R
Sbjct: 2104 ------------------EAEQVEITVGRFRGQKPTLWA--LLNSEYVTEE--KKLQLVR 2141

Query: 1943 KFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSS-------RHESVSKIS 1995
             +    R    ++ Q    +  K           G+   + +S          E +  + 
Sbjct: 2142 MYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLE 2201

Query: 1996 TISSVRNLTIRSSSFSDTLEESSPIAAIF-----DTENLEKISITEGIERGIVDSITGQR 2050
            T  S     +        LE +S IA +           EK+SI + + +G++   T   
Sbjct: 2202 TGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALV 2261

Query: 2051 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSA 2110
            LLEAQA TG +I P    +LS+++ V  GV+  ++  +L  A++A  G+      +++S 
Sbjct: 2262 LLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISL 2321

Query: 2111 AEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSS 2170
             +A+++  +  E G R LE Q  TGG++DP    R+  + A R+G+ D    + L D S 
Sbjct: 2322 FQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSD 2381

Query: 2171 YAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSS 2211
              K    P T   ++Y   + R + +  TGL +L+ A   S
Sbjct: 2382 DTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRGS 2422



 Score =  330 bits (847), Expect = 7e-90
 Identities = 215/519 (41%), Positives = 294/519 (56%), Gaps = 34/519 (6%)

Query: 1378 AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASPK--EK 1429
            A  L E Q      LD   + K SV+E      V  E++  L  A   A     P   + 
Sbjct: 1927 ATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDT 1986

Query: 1430 YSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYA 1489
              L +A +K+LI     + LLE Q ATGG+IDP  + +L +++A  R  +  D    I  
Sbjct: 1987 IPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISD 2046

Query: 1490 AEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIA---SGGVVDPVNSVFLPK 1546
             +     F DP + + VS  E  ++     +TG  L     A   S  + D        +
Sbjct: 2047 QKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALEAE 2106

Query: 1547 DVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE---RCRIEPHTGLLLLS 1603
             V +  G      +R       +  N      +KK+  V++     R  ++    L+L  
Sbjct: 2107 QVEITVGR-----FRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILEL 2161

Query: 1604 VQKRSMS-----FQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE--RIKDFLQ 1656
            ++K+  S     FQGIR+ +T +EL+ S I+    + +LE+G+ +  E+ E  R+K +L+
Sbjct: 2162 IEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLE 2221

Query: 1657 GSSCIAGIYNETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRL 1711
            G+SCIAG+      Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL
Sbjct: 2222 GTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRL 2281

Query: 1712 PVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEA 1771
             VEE    G+VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEA
Sbjct: 2282 SVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA 2341

Query: 1772 QIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLK 1831
            QIATGG+IDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL 
Sbjct: 2342 QIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLL 2401

Query: 1832 ERCIKDEETGLCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
             RC+ D +TGL +L L  +     Q+    +  LR  RV
Sbjct: 2402 RRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDARV 2440



 Score =  308 bits (788), Expect = 5e-83
 Identities = 271/950 (28%), Positives = 431/950 (45%), Gaps = 151/950 (15%)

Query: 1353 ETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQ 1410
            E     E    T+++ F GLR  VT  +L + ++ID+   ++L  G+ + ++V S    Q
Sbjct: 544  ELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQ 603

Query: 1411 PFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLT 1469
             +L+G G IAG      +E+ S+ EA+ K L+ P + ++LLEAQAATG IIDP  N+  +
Sbjct: 604  RYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHS 663

Query: 1470 VDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQ 1529
            V+ A+   +I  D   ++ +AE+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQ
Sbjct: 664  VEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQ 723

Query: 1530 IASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE 1589
            IA+GGV+DPV+S  +P DVA  RG  D+ L   L DP D  K F DP T + ++Y+QL E
Sbjct: 724  IATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLE 783

Query: 1590 RCRIEPHTGLLLLSVQK---------RSMSFQGI----------RQPVTVTELVDS---- 1626
            RC  +P TGL LL +              +FQ +           Q V+  EL++S    
Sbjct: 784  RCVRDPETGLYLLPLSSTQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFS 843

Query: 1627 -----GILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKL---GIYEA 1678
                  +LR     E+  GQ++     E  +   Q    +  + +  T  +L   GI + 
Sbjct: 844  EGRRRQLLRRYRQREVTLGQVAKLLEAETQR---QADIMLPALRSRVTVHQLLEAGIIDQ 900

Query: 1679 MKIGLVRPGT----ALELLE-------AQAATGFIVDPVSNLRLPVEEAYKRGLVG---- 1723
              +  V  GT    AL L++          A G +    S  RL + +A ++ L+G    
Sbjct: 901  QLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVA 960

Query: 1724 ----------------------------------IEFKEKLLSAERAVTGYNDPETGNII 1749
                                               E   +L  AE A+ G+ DP +G  +
Sbjct: 961  LALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQV 1020

Query: 1750 SLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDP 1809
            S+FQAM K LI      RLLEAQ+ATGGIIDP   H LP+ +A +RGY ++E+   LS  
Sbjct: 1021 SVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSSS 1080

Query: 1810 SDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVI 1869
            S+    F  P+ +   +Y QL E C +DE +GL LLPL E    + T ++     + V  
Sbjct: 1081 SET---FPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPG 1137

Query: 1870 VDPETN-----KEMSVQEAYKKGLID-----YETFKELCEQECEWEEITITGSDGSTRVV 1919
                T+           E  ++GL++       T  +L      W + T   +      V
Sbjct: 1138 AKDGTSLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQAR---V 1194

Query: 1920 LVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVS 1979
            +V    G    +   +D G++ ++  +    G+ S  Q A+  ++K     +   G+G  
Sbjct: 1195 MVPGPRGEVPAVW-LLDAGIITQETLEALAQGTQSPAQVAEQPAVK-----ACLWGTGCV 1248

Query: 1980 DDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIE 2039
              V       S +K S   +VR+  + +      LE       + D  N +++S+ + ++
Sbjct: 1249 AGVL---LQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVK 1305

Query: 2040 RGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGF 2099
             G+V     ++L +A+    G   P +   LSL  A+ +G++                  
Sbjct: 1306 VGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLV------------------ 1347

Query: 2100 EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG-RISTEEAIRKGFID 2158
                                P   G   L+ Q  TGG+VDP VHG  +    A R G +D
Sbjct: 1348 --------------------PQNEGLPLLQVQLATGGVVDP-VHGVHLPQAAACRLGLLD 1386

Query: 2159 GRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAAS 2208
             + +Q L       K    P  + +++Y+    R + +  TGL LL   S
Sbjct: 1387 TQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPS 1436



 Score =  296 bits (758), Expect = 2e-79
 Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)

Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 2706 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 2765

Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 2766 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 2825

Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 2826 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 2885

Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL  RC+ D +TG
Sbjct: 2886 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 2945

Query: 1842 LCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
            L +L L  +     Q+    +  LR  RV
Sbjct: 2946 LYMLQLAGRGSAVHQLSEELRCALRDARV 2974



 Score =  296 bits (758), Expect = 2e-79
 Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)

Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 3240 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 3299

Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 3300 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 3359

Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 3360 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 3419

Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL  RC+ D +TG
Sbjct: 3420 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 3479

Query: 1842 LCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
            L +L L  +     Q+    +  LR  RV
Sbjct: 3480 LYMLQLAGRGSAVHQLSEELRCALRDARV 3508



 Score =  296 bits (758), Expect = 2e-79
 Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)

Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 3774 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 3833

Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 3834 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 3893

Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 3894 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 3953

Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL  RC+ D +TG
Sbjct: 3954 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 4013

Query: 1842 LCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
            L +L L  +     Q+    +  LR  RV
Sbjct: 4014 LYMLQLAGRGSAVHQLSEELRCALRDARV 4042



 Score =  296 bits (758), Expect = 2e-79
 Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)

Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 4308 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4367

Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 4368 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4427

Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 4428 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 4487

Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL  RC+ D +TG
Sbjct: 4488 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 4547

Query: 1842 LCLLPLKEKKK---QVQTSQKNTLRKRRV 1867
            L +L L  +     Q+    +  LR  RV
Sbjct: 4548 LYMLQLAGRGSAVHQLSEELRCALRDARV 4576



 Score =  293 bits (750), Expect = 1e-78
 Identities = 153/246 (62%), Positives = 187/246 (76%), Gaps = 7/246 (2%)

Query: 1609 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 1666
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 4842 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4901

Query: 1667 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 1721
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 4902 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4961

Query: 1722 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 1781
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 4962 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 5021

Query: 1782 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 1841
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL +R   D ETG
Sbjct: 5022 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETG 5081

Query: 1842 LCLLPL 1847
            L  L L
Sbjct: 5082 LLFLSL 5087



 Score =  229 bits (584), Expect = 2e-59
 Identities = 241/958 (25%), Positives = 411/958 (42%), Gaps = 130/958 (13%)

Query: 1311 EERCRRKLED--STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLV 1368
            EE+ R  LED    R T  QL     R+ +E   L Q                   ++++
Sbjct: 1155 EEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQ-------------------ARVM 1195

Query: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASASP 1426
              G R +V A+ L +  +I + TL+ L +G +S  +VA +  ++  L G G +AG    P
Sbjct: 1196 VPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQP 1255

Query: 1427 K-EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485
               K S+ +A R  L+       LLEAQ A+G ++DP  N++L+V+ A+   L+  +  +
Sbjct: 1256 SGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSE 1315

Query: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545
            Q+  AE+A  G+ DP+S  ++S+ +A++K L+ +  G+ LL+ Q+A+GGVVDPV+ V LP
Sbjct: 1316 QLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLP 1375

Query: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605
            +  A   GL+D    + L       K F DP  + +V+Y QL+ERC  +  TGLLLL + 
Sbjct: 1376 QAAACRLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLP 1435

Query: 1606 K---------RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE------- 1649
                       +++ + ++ PV+        +   S  + L S  +  D+  E       
Sbjct: 1436 SDTVLEVDDHTAVALRAMKVPVSTGRFKGCSV---SLWDLLLSEYVGADKRRELVALCRS 1492

Query: 1650 -RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSN 1708
             R     Q  S +  +     +Q L   +A   GL +  +A +L  AQ  +   +D +S 
Sbjct: 1493 GRAAALRQVVSAVTALVEAAERQPL---QATFRGLRKQVSARDLFRAQLISRKTLDELSQ 1549

Query: 1709 LRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRL 1768
                V+E  +   V     ++ L     + G     T   +S+ +A+ + ++  G  + L
Sbjct: 1550 GTTTVKEVAEMDSV-----KRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVL 1604

Query: 1769 LEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYL 1828
            LEAQ ATG IIDP E+ +L V+ A+K G F +E    L        G+ DP T + ++  
Sbjct: 1605 LEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLF 1664

Query: 1829 QLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGL 1888
            Q  ++ +   E G+ LL     + Q+ T            I+DP  +  + V  AY+ G 
Sbjct: 1665 QAMQKDLIVREHGIRLL-----EAQIATGG----------IIDPVHSHRVPVDVAYRCGY 1709

Query: 1889 IDYETFKELCEQECEWEEITITGS-DGSTRVVLVDR---------------KTGSQYDIQ 1932
             D E  + L +   + +      + +  T + L++R               K G  Y   
Sbjct: 1710 FDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQIIKKGENYVYI 1769

Query: 1933 DAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVS 1992
            +   + ++      Q R+  + + +FAD +          S    +S   F+  R   + 
Sbjct: 1770 NEATRHVL------QSRTAKMRVGRFADQVV---------SFWDLLSSPYFTEDRKREL- 1813

Query: 1993 KISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIE-RGIVDSITGQRL 2051
                   ++    +S      LE  +      +T+N       +GI+   I   +T   L
Sbjct: 1814 -------IQEYGAQSGGLEKLLEIITTTIEETETQN-------QGIKVAAIRGEVTAADL 1859

Query: 2052 LEAQACTGGIIHP-----TTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKK 2106
              ++      +H      T GQ LS  + V   +   D             G      ++
Sbjct: 1860 FNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSD----------CIAGVTVPSTRE 1909

Query: 2107 KMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQ 2166
             MS  EA +++ +P       LE Q  TG L+DP    ++S +EA+  G ++    +RL 
Sbjct: 1910 VMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLL 1969

Query: 2167 DTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAP 2224
                 A     P T   I    A+ + ++E    LRLLE   V++ G+  P +    P
Sbjct: 1970 KAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLLE-VQVATGGVIDPQHHHRLP 2026



 Score =  228 bits (581), Expect = 5e-59
 Identities = 174/594 (29%), Positives = 297/594 (50%), Gaps = 37/594 (6%)

Query: 1322 TRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL 1381
            T + + +L  E       ++KL +    +  ET+T+         +    +R +VTA  L
Sbjct: 1806 TEDRKRELIQEYGAQSGGLEKLLEIITTTIEETETQ------NQGIKVAAIRGEVTAADL 1859

Query: 1382 YECQLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASA-SPKEKYSLVEAKRK 1438
            +  ++ID+ TL  L  G+   + +++   ++P+L G+  IAG +  S +E  SL EA RK
Sbjct: 1860 FNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRK 1919

Query: 1439 KLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFD 1498
            +LI       LLEAQAATG ++DP   +KL+VD A+   L++ + R+++  AE+A TG+ 
Sbjct: 1920 ELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYR 1979

Query: 1499 DPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRD 1558
            DP +G T+ + +A++K LI++   +RLLE Q+A+GGV+DP +   LP + A  RG + +D
Sbjct: 1980 DPATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKD 2039

Query: 1559 LYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGI---R 1615
            +Y  ++D +  +K FVDP T++KVSY +L+ERCR +  TG +L  V K +   + I    
Sbjct: 2040 IYALISDQKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNKAARDSEHIDDET 2099

Query: 1616 QPVTVTELVDSGILR-----PSTVNELESGQISYDEVGERIKDF----LQGSSCIAGIYN 1666
            +     E V+  + R     P+    L S  ++ ++  + ++ +     +    +A +  
Sbjct: 2100 RRALEAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLIL 2159

Query: 1667 E-TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIE 1725
            E   KQ+         G+ R  TA ELL +   T  ++  +   R   +E  +   V   
Sbjct: 2160 ELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRY 2219

Query: 1726 FKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESH 1785
             +     A   V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + 
Sbjct: 2220 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 2279

Query: 1786 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 1845
            RL V+     G    E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL
Sbjct: 2280 RLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 2339

Query: 1846 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
                 + Q+ T            ++DP  +  + V  AY++G  D E  + L +
Sbjct: 2340 -----EAQIATGG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 2378



 Score =  198 bits (504), Expect = 4e-50
 Identities = 105/248 (42%), Positives = 167/248 (67%), Gaps = 8/248 (3%)

Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 4840 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4899

Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 4900 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4959

Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 4960 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 5019

Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++Y+QL +R  ++P 
Sbjct: 5020 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPE 5079

Query: 1597 TGLLLLSV 1604
            TGLL LS+
Sbjct: 5080 TGLLFLSL 5087



 Score =  197 bits (501), Expect = 1e-49
 Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)

Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 2704 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 2763

Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 2764 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 2823

Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 2824 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 2883

Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++YVQL  RC  +P 
Sbjct: 2884 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 2943

Query: 1597 TGLLLLSVQKR 1607
            TGL +L +  R
Sbjct: 2944 TGLYMLQLAGR 2954



 Score =  197 bits (501), Expect = 1e-49
 Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)

Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 3238 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3297

Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 3298 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3357

Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 3358 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 3417

Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++YVQL  RC  +P 
Sbjct: 3418 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 3477

Query: 1597 TGLLLLSVQKR 1607
            TGL +L +  R
Sbjct: 3478 TGLYMLQLAGR 3488



 Score =  197 bits (501), Expect = 1e-49
 Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)

Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 3772 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3831

Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 3832 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3891

Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 3892 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 3951

Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++YVQL  RC  +P 
Sbjct: 3952 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4011

Query: 1597 TGLLLLSVQKR 1607
            TGL +L +  R
Sbjct: 4012 TGLYMLQLAGR 4022



 Score =  197 bits (501), Expect = 1e-49
 Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)

Query: 1365 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 1422
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 4306 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4365

Query: 1423 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 1476
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 4366 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4425

Query: 1477 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 1536
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 4426 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 4485

Query: 1537 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 1596
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++YVQL  RC  +P 
Sbjct: 4486 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4545

Query: 1597 TGLLLLSVQKR 1607
            TGL +L +  R
Sbjct: 4546 TGLYMLQLAGR 4556



 Score =  191 bits (485), Expect = 7e-48
 Identities = 120/351 (34%), Positives = 198/351 (56%), Gaps = 28/351 (7%)

Query: 1285 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE-TQSQLETER--------SR 1335
            ER + + +   +   + +   + + I++  RR LE    E T  +   ++        S 
Sbjct: 2070 ERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALEAEQVEITVGRFRGQKPTLWALLNSE 2129

Query: 1336 YQREIDKLRQ-RPYGSH--RETQTECEWTVD--------TSKLVFDGLRKKVTAMQLYEC 1384
            Y  E  KL+  R Y +H  R  QT  +  ++           L F G+R+++TA +L   
Sbjct: 2130 YVTEEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSS 2189

Query: 1385 QLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASASPK------EKYSLVEAK 1436
             +I +  L  L  G+ + +E+  +  ++ +L G   IAG     K      EK S+ +A 
Sbjct: 2190 AIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAM 2249

Query: 1437 RKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITG 1496
             K ++ P + ++LLEAQAATG +IDP RN +L+V+  +   ++  + ++++ +AE+A+TG
Sbjct: 2250 WKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTG 2309

Query: 1497 FDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLID 1556
            + DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D
Sbjct: 2310 YTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFD 2369

Query: 1557 RDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKR 1607
             ++ R L DP D  K F DP T + ++YVQL  RC  +P TGL +L +  R
Sbjct: 2370 EEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 2420



 Score =  108 bits (270), Expect = 6e-23
 Identities = 117/481 (24%), Positives = 195/481 (40%), Gaps = 44/481 (9%)

Query: 1735 RAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYK 1794
            R++ G     +G   S++ AM + L+  G G  LLEAQ ATGG++D      LPV  A +
Sbjct: 41   RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100

Query: 1795 RGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQV 1854
            +G    EL E L      T G+ DP   E L   Q   + + D   G   L +     Q+
Sbjct: 101  QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEV-----QL 155

Query: 1855 QTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDG 1914
             T            +VDP     ++ + A  +GL+D ET+ +L E E    ++     + 
Sbjct: 156  ATGG----------LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPN- 204

Query: 1915 STRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSM 1974
                  ++R T  Q   +     G           SG   L       S+   V  +  +
Sbjct: 205  -----TLERLTYHQLLERCVRAPG-----------SGLALLPLKITFRSMGGAVSAAELL 248

Query: 1975 GSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISI 2034
              G+ D+       E   +++ +       +R       LE +  +A +       K S 
Sbjct: 249  EVGILDEQAVQGLREG--RLAAVDVSARAEVRRY-----LEGTGSVAGVVLLPEGHKKSF 301

Query: 2035 TEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQK 2094
             +     ++   T   LLEAQA T  ++ P TGQ+L + +AV  G++  ++  +L  A++
Sbjct: 302  FQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQ 361

Query: 2095 AFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRK 2154
            A  G        ++   +A+K+  +      R L+ Q  TGGLV P    R+  E A+R 
Sbjct: 362  AVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRC 421

Query: 2155 GFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGL 2214
            G +D    ++L    S++       T   + Y+  +   + +  TGL  L  +     G 
Sbjct: 422  GCLDEDTQRQLSQAGSFS-----DGTHGGLRYEQLLALCVTDPETGLAFLPLSGGPRGGE 476

Query: 2215 P 2215
            P
Sbjct: 477  P 477



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 58/182 (31%), Positives = 99/182 (54%)

Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 2775 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 2834

Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 2835 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 2894

Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2209
             A R+G+ D    + L D S   K    P T   ++Y   + R + +  TGL +L+ A  
Sbjct: 2895 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 2954

Query: 2210 SS 2211
             S
Sbjct: 2955 GS 2956



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 58/182 (31%), Positives = 99/182 (54%)

Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 3309 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 3368

Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 3369 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 3428

Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2209
             A R+G+ D    + L D S   K    P T   ++Y   + R + +  TGL +L+ A  
Sbjct: 3429 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 3488

Query: 2210 SS 2211
             S
Sbjct: 3489 GS 3490



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 58/182 (31%), Positives = 99/182 (54%)

Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 3843 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 3902

Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 3903 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 3962

Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2209
             A R+G+ D    + L D S   K    P T   ++Y   + R + +  TGL +L+ A  
Sbjct: 3963 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 4022

Query: 2210 SS 2211
             S
Sbjct: 4023 GS 4024



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 58/182 (31%), Positives = 99/182 (54%)

Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 4377 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 4436

Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 4437 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 4496

Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2209
             A R+G+ D    + L D S   K    P T   ++Y   + R + +  TGL +L+ A  
Sbjct: 4497 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 4556

Query: 2210 SS 2211
             S
Sbjct: 4557 GS 4558



 Score = 95.1 bits (235), Expect = 7e-19
 Identities = 56/175 (32%), Positives = 96/175 (54%)

Query: 2030 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2089
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 4911 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 4970

Query: 2090 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2149
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 4971 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 5030

Query: 2150 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
             A R+G+ D    + L D S   K    P T   ++Y   + R+ ++  TGL  L
Sbjct: 5031 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFL 5085



 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 55/191 (28%), Positives = 100/191 (52%), Gaps = 2/191 (1%)

Query: 2016 ESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDA 2075
            ++  IA ++   + +  S+   +E+G++ +  GQ LLEAQA TGG++    GQ L +  A
Sbjct: 39   QARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKA 98

Query: 2076 VSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTG 2135
            + QG++  ++  +L  A++A  G+    G +K++  +A+ ++ +    GQ +LE Q  TG
Sbjct: 99   LQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATG 158

Query: 2136 GLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTC--PKTKLKISYKDAINRS 2193
            GLVDP     ++ E A  +G +D     +L +       L    P T  +++Y   + R 
Sbjct: 159  GLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERC 218

Query: 2194 MVEDITGLRLL 2204
            +    +GL LL
Sbjct: 219  VRAPGSGLALL 229



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 103/426 (24%), Positives = 173/426 (40%), Gaps = 69/426 (16%)

Query: 1118 IEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL 1177
            I D+K  RK   D   Q+K  Y +LQ+ R   +E+ GW      KA ++ E+  +  R  
Sbjct: 2044 ISDQKHMRKRFVDPNTQEKVSYRELQE-RCRPQEDTGWVLFPVNKAARDSEHIDDETRRA 2102

Query: 1178 LQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDEL 1237
            L+ E       + E+     R Q+             +LL    V E+ K +L R+    
Sbjct: 2103 LEAE-------QVEITVGRFRGQK---------PTLWALLNSEYVTEEKKLQLVRM---- 2142

Query: 1238 NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLR 1297
                      T  ++ L+   Q I   + + +T  S K    + I  +   SE   +++ 
Sbjct: 2143 --------YRTHTRRALQTVAQLILELIEKQET--SNKHLWFQGIRRQITASELLSSAI- 2191

Query: 1298 SEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE--------IDKLRQRPYG 1349
                        I E   + LE     TQ  +E +R +   E        +   + +P  
Sbjct: 2192 ------------ITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGR 2239

Query: 1350 SHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE----- 1404
              + +  +  W          G+ +  TA+ L E Q      +D +   + SVEE     
Sbjct: 2240 QEKMSIYQAMW---------KGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAG 2290

Query: 1405 -VASEIQPFLRGAGSIAGASASP--KEKYSLVEAKRKKLISPESTVMLLEAQAATGGIID 1461
             V SEIQ  L  A         P   ++ SL +A +K LI  E  + LLEAQ ATGG+ID
Sbjct: 2291 VVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVID 2350

Query: 1462 PHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRET 1521
            P  + ++ VD A  R   D +  + +        GF DP + + ++  + +++ + D +T
Sbjct: 2351 PVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDT 2410

Query: 1522 GMRLLE 1527
            G+ +L+
Sbjct: 2411 GLYMLQ 2416



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 42/170 (24%), Positives = 82/170 (48%), Gaps = 7/170 (4%)

Query: 1611 FQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEV-------GERIKDFLQGSSCIAG 1663
            ++G+ +P T   L+++       ++ + + ++S +E        GE  +  L     + G
Sbjct: 4920 WKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTG 4979

Query: 1664 IYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVG 1723
              +  T Q++ +++AM+  L+     + LLEAQ ATG ++DPV + R+PV+ AY+RG   
Sbjct: 4980 YTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFD 5039

Query: 1724 IEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQI 1773
             E    L        G+ DP T   ++  Q + +  ++   G+  L   +
Sbjct: 5040 EEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 51/171 (29%), Positives = 82/171 (47%), Gaps = 8/171 (4%)

Query: 1368 VFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAG 1421
            ++ G+ +  TA+ L E Q      +D +   + SVEE      V  EIQ  L  A     
Sbjct: 4919 MWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVT 4978

Query: 1422 ASASPK--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLI 1479
                P   ++ SL +A +K LI  E  + LLEAQ ATGG+IDP  + ++ VD A  R   
Sbjct: 4979 GYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 5038

Query: 1480 DFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQI 1530
            D +  + +        GF DP + + ++  + +++  +D ETG+  L   +
Sbjct: 5039 DEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 2765 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 2824

Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 2825 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 2879

Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 2880 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 2912



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 3299 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 3358

Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 3359 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 3413

Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 3414 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 3446



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 3833 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 3892

Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 3893 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 3947

Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 3948 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 3980



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 4367 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 4426

Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 4427 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 4481

Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 4482 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 4514



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 1737 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 1796
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 4901 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 4960

Query: 1797 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 1856
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 4961 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 5015

Query: 1857 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 1899
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 5016 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 5048



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 43/168 (25%), Positives = 80/168 (47%), Gaps = 8/168 (4%)

Query: 1456 TGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGF-----DDPFSGKTVSVSE 1510
            T GI+ P     L   +   +++ + D  ++       I G      D P   + +S+ +
Sbjct: 4858 TSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQ 4917

Query: 1511 AIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQ 1570
            A+ K ++   T + LLEAQ A+G V+DPV ++ L  + A+A G++  ++   L     + 
Sbjct: 4918 AMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAV 4977

Query: 1571 KNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPV 1618
              + DP T +++S  Q  ++  I    G+ LL  Q   ++  G+  PV
Sbjct: 4978 TGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQ---IATGGVIDPV 5022



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 2701 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 2750

Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 2751 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 2810

Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 2811 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 2870

Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
            RLLE A +++ G+  P +    P
Sbjct: 2871 RLLE-AQIATGGVIDPVHSHRVP 2892



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 3235 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 3284

Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 3285 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 3344

Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 3345 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 3404

Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
            RLLE A +++ G+  P +    P
Sbjct: 3405 RLLE-AQIATGGVIDPVHSHRVP 3426



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 3769 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 3818

Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 3819 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 3878

Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 3879 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 3938

Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
            RLLE A +++ G+  P +    P
Sbjct: 3939 RLLE-AQIATGGVIDPVHSHRVP 3960



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 4303 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 4352

Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 4353 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 4412

Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 4413 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 4472

Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
            RLLE A +++ G+  P +    P
Sbjct: 4473 RLLE-AQIATGGVIDPVHSHRVP 4494



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2027 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2086
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 4837 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 4886

Query: 2087 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2141
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 4887 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 4946

Query: 2142 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2201
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 4947 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 5006

Query: 2202 RLLEAASVSSKGLPSPYNMSSAP 2224
            RLLE A +++ G+  P +    P
Sbjct: 5007 RLLE-AQIATGGVIDPVHSHRVP 5028



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 35/150 (23%), Positives = 62/150 (41%), Gaps = 7/150 (4%)

Query: 2074 DAVSQGVIDQDMATRL------KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRF 2127
            ++  Q  + + MA  L      +P  ++  G       +  S   A+++  LP   GQ  
Sbjct: 15   NSTEQASVPRAMAATLGAGTPPRPQARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQAL 74

Query: 2128 LEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYK 2187
            LE Q  TGGLVD      +   +A+++G +     ++L            P    K++  
Sbjct: 75   LEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALF 134

Query: 2188 DAINRSMVEDITGLRLLEAASVSSKGLPSP 2217
             AI + +V+   G   LE   +++ GL  P
Sbjct: 135  QAIGKEVVDRALGQSWLE-VQLATGGLVDP 163


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score =  243 bits (620), Expect = 2e-63
 Identities = 147/378 (38%), Positives = 224/378 (59%), Gaps = 19/378 (5%)

Query: 1831 KERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLID 1890
            KER ++D    +     +E  ++ QT + N   K  + I++PET K+MS  EAYK+G+ID
Sbjct: 1655 KERTLRDLHAKVSR---EELSQETQTRETNLSTK--ISILEPETGKDMSPYEAYKRGIID 1709

Query: 1891 YETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRS 1950
               + +L E EC+WEE+T +G  G   V+L DRK+G QY I+ A+    + ++ +  Y+ 
Sbjct: 1710 RGQYLQLQELECDWEEVTTSGPCGEESVLL-DRKSGKQYSIEAALRCRRISKEEYHLYKD 1768

Query: 1951 GSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSF 2010
            G L +++FA +++ +    +S S+GS +S    +S   +S S  S             SF
Sbjct: 1769 GHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSP------------SF 1816

Query: 2011 SDTL-EESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2069
            S  L ++S PIA I+DT    K SI   + + ++D ITGQ+LLEAQA TGGI+   + ++
Sbjct: 1817 SLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRER 1876

Query: 2070 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2129
             S+  A+ +G+I+     RL  AQKAF G E    KK++S  EAV++ W+P E+    L+
Sbjct: 1877 YSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQ 1936

Query: 2130 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDA 2189
             Q+LTGGL+DP+  GRI  ++A+  G I    AQ LQD SSY K LT P +K ++SYK+A
Sbjct: 1937 VQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEA 1996

Query: 2190 INRSMVEDITGLRLLEAA 2207
            + R   + ++GL LL AA
Sbjct: 1997 MGRCRKDPLSGLLLLPAA 2014



 Score =  176 bits (446), Expect = 2e-43
 Identities = 267/1129 (23%), Positives = 495/1129 (43%), Gaps = 141/1129 (12%)

Query: 790  RLTEEETVCLDLD-KVEAYRCGLK-KIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYP 847
            RL E+E V    D ++E     +K +++ +   +  L A ++   QK  Q+ S+     P
Sbjct: 953  RLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQP 1012

Query: 848  LYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRN-----------YRDNYQ 896
                      ++VTQ+       D  +D +   L  QI+QLR             +    
Sbjct: 1013 HL------LTKEVTQVER-----DPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELL 1061

Query: 897  AFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCAN 956
            A  K   D K +    E +K   +  +++     +    E + +R ++EE   +A+L A 
Sbjct: 1062 ALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEA--VAKLQAR 1119

Query: 957  SIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRF 1016
             I+D E  ++S    +E  + +   + + Q P   +LQE++ + +   E  T++    R 
Sbjct: 1120 -IEDLERAISS----VEPKVIVKEVKKVEQDPG--LLQESSRLRSLLEEERTKNATLARE 1172

Query: 1017 LSEMLKSLEDLKLKNTKIEVLE---EELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
            LS++      ++ +  K+++ E   E  ++  +   E       L +   K      + +
Sbjct: 1173 LSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVE 1232

Query: 1074 AKLASLEELKRQAE-LDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRF 1132
              L  LE L+ Q   ++ K   Q + + + +  E+  +I RL  ++ +        +++ 
Sbjct: 1233 KLLPDLEVLRAQKPTVEYKEVTQEVVR-HERSPEVLREIDRLKAQLNELVNSHGRSQEQL 1291

Query: 1133 DQQKNDYDQLQKAR-QCEKENLGWQKLESEK-AIKEKEYEIERLRVLLQEEGTRKREYEN 1190
             + + + D+ ++ R + E + +  + +  EK  + EKE   ERLR  ++E   ++R  E+
Sbjct: 1292 IRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKE--AERLRQEVREAAQKRRAAED 1349

Query: 1191 ELAKASNR---IQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1247
             + +  ++   ++  K +   VVQE       + V ++D     +L +E +R   +L+ E
Sbjct: 1350 AVYELQSKRLLLERRKPEEKVVVQE-------VVVTQKDP----KLREEHSRLSGSLDEE 1398

Query: 1248 TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREK-------SEREKNSLRSEI 1300
               +++LE E QQ++  + + +   S +E+  +K+  ERE         E EK     + 
Sbjct: 1399 VGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQE 1458

Query: 1301 ERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRY----------QREIDKLRQRPYGS 1350
            + +  E+ ++E+     LE ST   +  L+ E+++           Q +ID L Q+    
Sbjct: 1459 KIIMEEVVKLEKD--PDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVL-QKAKSQ 1515

Query: 1351 HRETQTEC------EWTVDTSKLVFDGLRKKVTAMQLYECQ---LIDKTTLDKLLKGKKS 1401
             +    E           D    V++ L ++ TA Q  E +   L ++    + L    S
Sbjct: 1516 EKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWS 1575

Query: 1402 VEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIID 1461
             EE  SE+Q     A    G     +E  +L   K+++ +  +    LL  +  +     
Sbjct: 1576 REE--SELQRARDQADQECGRLQ--QELRALERQKQQQTLQLQEESKLLSQKTESERQKA 1631

Query: 1462 PHRNEKLT-VDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRE 1520
              R ++L+ +++AI R+      + QIY  E+ +       S       E + +    RE
Sbjct: 1632 AQRGQELSRLEAAILRE------KDQIYEKERTLRDLHAKVS------REELSQETQTRE 1679

Query: 1521 TGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLND------------PRD 1568
            T    L  +I+   +++P     +    A  RG+IDR  Y  L +            P  
Sbjct: 1680 TN---LSTKIS---ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCG 1733

Query: 1569 SQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGI 1628
             +   +D  + K+ S ++   RCR         +S ++  +   G   P++   L+ +G 
Sbjct: 1734 EESVLLDRKSGKQYS-IEAALRCR--------RISKEEYHLYKDG-HLPISEFALLVAGE 1783

Query: 1629 LRPST---VNELESGQISYDEVGERIKDFLQGSSC--------IAGIYNETTKQKLGIYE 1677
             +PS+   +  + S         +    F    S         IAGIY+ TT  K  I  
Sbjct: 1784 TKPSSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKT 1843

Query: 1678 AMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAV 1737
            A+   ++ P T  +LLEAQAATG IVD +S  R  V +A +RGL+     ++LL+A++A 
Sbjct: 1844 AVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAF 1903

Query: 1738 TGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGY 1797
            TG  DP T   +S+ +A+ K  + +   +  L+ Q  TGG+IDPK + R+P+  A   G 
Sbjct: 1904 TGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGM 1963

Query: 1798 FNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLP 1846
             +EEL+++L D S   K   DP ++E L+Y +   RC KD  +GL LLP
Sbjct: 1964 ISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012



 Score =  124 bits (312), Expect = 8e-28
 Identities = 86/341 (25%), Positives = 163/341 (47%), Gaps = 10/341 (2%)

Query: 195 MRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEE 254
           + Q++ ++    +G  +A +EQ I  H  +   I  Y  QL  +            +  +
Sbjct: 156 LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGP-----DAATIRSQ 210

Query: 255 YENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQ-KQEAFS 313
           Y +LLKA+  R   L  L   +Q  +R++  + + +   L  DWSD   + A  ++E   
Sbjct: 211 YRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 270

Query: 314 IRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLK 373
            +  +L  +E+ +N+L+ + +++V  +HPA   I+A+ + L+ +W   L +  C +  L+
Sbjct: 271 FKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 330

Query: 374 ENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKR 433
               Y +F EEA S    L  L  ++  KY      P     E +++LE E +++   +R
Sbjct: 331 HVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTER 390

Query: 434 QVQNLVNKSKKIVQL-KPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSK 492
              +L  +S+ +  L + RNP     +P+ + ++CD+   +  + +G+   L DN +   
Sbjct: 391 ATGDLQRRSRDVAPLPQRRNP---PQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHA 447

Query: 493 WYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAI 533
           W V GPGG     P+    IP P+P AV  + ++    +A+
Sbjct: 448 WVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQAL 488



 Score =  102 bits (253), Expect = 6e-21
 Identities = 175/824 (21%), Positives = 340/824 (41%), Gaps = 128/824 (15%)

Query: 993  LQEAADVHARYIELLTR-SGDYYRFLSEMLK----SLEDLKLKNTKIEVLEEELRLARDA 1047
            L E  + H R  E L R  G+   +  E  K    ++    +++ K  VLE+E    R  
Sbjct: 1277 LNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQE 1336

Query: 1048 NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
              E   K +  +  + + Q++    + +    + + ++  +  K  K            L
Sbjct: 1337 VREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPK------------L 1384

Query: 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEK 1167
             E+ +RL+  +++E  RR+ +E        +  QL+   + ++  L +Q+  S+K   E+
Sbjct: 1385 REEHSRLSGSLDEEVGRRRQLE-------LEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437

Query: 1168 EY--------EIERLRVLLQE----EGTRKREYENELAKASNRIQ----ESKNQCTQVVQ 1211
            E         E+E+    +QE    E   K E + +L K++  ++    + K Q T++ +
Sbjct: 1438 ELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNR 1497

Query: 1212 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQ 1271
            E ++L V+I VL++ K++ + +  E+ R +     + RV   LE E+ ++   LN+ +T 
Sbjct: 1498 ECKNLQVQIDVLQKAKSQEKTIYKEVIRVQ-----KDRV---LEDERARVWEMLNRERTA 1549

Query: 1272 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLET 1331
               +EE  R++    +++E    +   E   LQ    + ++ C R L+   R  + Q + 
Sbjct: 1550 RQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGR-LQQELRALERQKQQ 1608

Query: 1332 ERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTT 1391
            +  + Q E   L Q+   +  E Q   +   + S+L    LR+K    Q+YE +   +T 
Sbjct: 1609 QTLQLQEESKLLSQK---TESERQKAAQRGQELSRLEAAILREKD---QIYEKE---RTL 1659

Query: 1392 LDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLE 1451
             D  L  K S EE++ E Q              +   K S++E +  K +SP        
Sbjct: 1660 RD--LHAKVSREELSQETQT----------RETNLSTKISILEPETGKDMSPY------- 1700

Query: 1452 AQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA----EKAITGFDDPFSGKTVS 1507
             +A   GIID  R + L +            D +++  +    E+++    D  SGK  S
Sbjct: 1701 -EAYKRGIID--RGQYLQLQELEC-------DWEEVTTSGPCGEESV--LLDRKSGKQYS 1748

Query: 1508 VSEAIKKNLIDRET-------GMRLLEAQIASGGVVDPVNSVFLPKDVALA--------- 1551
            +  A++   I +E         + + E  +   G   P +S+ +   ++ +         
Sbjct: 1749 IEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQS 1808

Query: 1552 RGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSF 1611
                       L D         D  T  K S      +  ++P TG  LL  Q  +   
Sbjct: 1809 TSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGI 1868

Query: 1612 QGI--RQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETT 1669
              +  R+  +V + ++ G++  ++   L + Q ++                  GI +  T
Sbjct: 1869 VDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAF-----------------TGIEDPVT 1911

Query: 1670 KQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEK 1729
            K++L + EA++ G +   + L  L+ Q  TG ++DP    R+P+++A   G++  E  + 
Sbjct: 1912 KKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQL 1971

Query: 1730 LLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQI 1773
            L           DP +   +S  +AM +   +   G+ LL A +
Sbjct: 1972 LQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 47/180 (26%), Positives = 75/180 (41%), Gaps = 32/180 (17%)

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAF--------IGFEGV----KGKKKM 2108
            I+ P TG+ +S  +A  +G+ID+    +L+  +  +         G E V    K  K+ 
Sbjct: 1688 ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQY 1747

Query: 2109 SAAEAV------KEKWLPYEAGQRFL-EFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA 2161
            S   A+      KE++  Y+ G   + EF  L  G   P     +S    I K  +   A
Sbjct: 1748 SIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPS--SSLSIGSIISKSPLASPA 1805

Query: 2162 AQR-----------LQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVS 2210
             Q            L D S     +    T  K S K A+ ++M++ ITG +LLEA + +
Sbjct: 1806 PQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAAT 1865


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  224 bits (570), Expect = 1e-57
 Identities = 391/1838 (21%), Positives = 751/1838 (40%), Gaps = 317/1838 (17%)

Query: 206  AWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFER 265
            ++G DL  V+  +  H   HN +      L K   D  + S   +L  +Y+ LL AS  R
Sbjct: 153  SFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAK-DGDKEQNS---ELRAKYQKLLAASQAR 208

Query: 266  MDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQ-LEVKEK 324
              HL  LQ+ +Q  + E+ W++   +  + YDWSD+N +   ++  +   +++ LE KE+
Sbjct: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEE 268

Query: 325  ELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKE-NAAYFQFFE 383
             +NKL  E DQL+  +HP  +                      I+ H++  +A + ++  
Sbjct: 269  RINKLHSEGDQLLAAEHPGRNS---------------------IEAHMEAVHADWKEYLN 307

Query: 384  EAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSK 443
                 E++LK ++D                   Q  E  K+ +++L   R+V + +N+  
Sbjct: 308  LLICEESHLKYMED-----------------YHQFHEDVKDAQELL---RKVDSDLNQKY 347

Query: 444  KIVQLKPRNPDYRSNKPI--ILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGV 501
                     PD++    I  +LR L D    +K++ K ++ +++   +R +         
Sbjct: 348  --------GPDFKDRYQIELLLRELDD---QEKVLDKYED-VVQGLQKRGQ--------- 386

Query: 502  DMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIR 561
              +VP       P  P+ V+  C  E   + +++      +   +  SW        K+ 
Sbjct: 387  -QVVPLKYRRETPLKPIPVEALCDFEGE-QGLISRGYSYTLQKNNGESWELMDSAGNKLI 444

Query: 562  AMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQT 621
            A  +  +      + +     L   Y+   + + GS       KR +Q +       Y+ 
Sbjct: 445  APAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS-------KRTLQQR-------YEV 490

Query: 622  LVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEH 681
            L  + PG                                +D Q   +L  L K+   ++ 
Sbjct: 491  LKTENPG------------------------------DASDLQGRQLLAGLDKVASDLDR 520

Query: 682  CEGRMTLKNLPLADQGSSHHITV-KINELKSVQNDSQAIAEVLNQL----KDMLANFRGS 736
             E  +T    P  +QG +   +  +  +LK++ N+   I     +     +  +    GS
Sbjct: 521  QEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGS 580

Query: 737  EKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEET 796
                 L+  V    +K E++  + D     +     L +++ Q+ ++L  +E  L +++T
Sbjct: 581  GTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDT 640

Query: 797  VCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856
            V      +++    L  +  +L  +KSLL  ++  LQ A+Q  S  + ++  +  DL + 
Sbjct: 641  VPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ 700

Query: 857  GEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMK 916
              +V +L  R+  + +Q++ R   L+       ++   +    ++L        S E  +
Sbjct: 701  EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIP----SYEPQE 756

Query: 917  FGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANS------IKDYELQLASYTS 970
                + +   L  QKNL  EI+ +    +EVQKI   CANS      +KDYEL+      
Sbjct: 757  TDSLSQMETKLKNQKNLLDEIASRE---QEVQKI---CANSQQYQQAVKDYELEAEK--- 807

Query: 971  GLETLLNIP-------IKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKS 1023
             L +LL++         KR  +QSP+  + +E A + A++ E+       Y    + L++
Sbjct: 808  -LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEV-------YAINRQRLQN 859

Query: 1024 LE---DLKLKNTKIEVLEEELRLAR-DANSENCNK-NKFLDQNLQKYQAECSQFKAKLAS 1078
            LE   +L  +  ++EV  E L+  R D+  E   K  K LD                   
Sbjct: 860  LEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD------------------- 900

Query: 1079 LEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQ--K 1136
             EE +R+ +L+             ++K   E+I  L  +   E   RK V  +      +
Sbjct: 901  -EETERRRQLEN------------EVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLE 947

Query: 1137 NDYDQLQK--ARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194
              + QLQ+  A +  K  L  ++LE+ +          +LR L QE     +EY   + K
Sbjct: 948  ESFQQLQRTLAEEQHKNQLLQEELEALQL---------QLRALEQETRDGGQEY---VVK 995

Query: 1195 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1254
               RI+  + Q  +V+Q RE L    +     +A +  L+    R  +  E ++R ++++
Sbjct: 996  EVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQ---RVAALAEEKSRAQEKV 1052

Query: 1255 -ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
             E E  ++QND  Q + +Y + +E  ++ +  REK E E + L+ +++RL+ E    E +
Sbjct: 1053 TEKEVVKLQND-PQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373
               K E    E  +  E E S   R+ +    +   S RE +TE              L 
Sbjct: 1112 ITVK-EVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE-KTE--------------LL 1155

Query: 1374 KKVTAMQLYECQLIDKTTLDKLLK-GKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSL 1432
            +K+ A++    +++ +  + ++++   K+  EVA+     +       GA    +   S 
Sbjct: 1156 RKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSE 1215

Query: 1433 VEAKRKKLISPESTVMLLEAQAATGGII----DPHRNEKLT------VDSAIARDLIDFD 1482
            +EA R++   P+     +E +  T  +I    DP   ++L       VD     +  D +
Sbjct: 1216 LEALRRR--GPQ-----VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLE 1268

Query: 1483 DRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSV 1542
                IY  +K I    D             K  +  +E    +L+ Q       DP    
Sbjct: 1269 ----IYQLKKEIQALKDT------------KPQVQTKEVVQEILQFQ------EDPQTK- 1305

Query: 1543 FLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERC------RIEPH 1596
               ++VA  R  +  +  + ++  R+      + + +K+    ++KER       R E  
Sbjct: 1306 ---EEVASLRAKLSEEQKKQVDLERERASQ-EEQIARKEEELSRVKERVVQQEVVRYEEE 1361

Query: 1597 TGLLL-LSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFL 1655
             GL    S    S+  +  +      EL      R     +LE  +       E  ++  
Sbjct: 1362 PGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQ 1421

Query: 1656 QGSSCIAGIYNETTKQKLGIYEAMKIGLVR-PGTA-------LELLEAQAATGFIVDPVS 1707
            +    +A +  E  + +  +    K+ L + P  A       L+L E Q     +   + 
Sbjct: 1422 RLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELE 1481

Query: 1708 NLRLPVEEAYKRGLVGIEFKEKLLSAE--RAVTGYNDPETGNIISLFQAMNKELIEKGHG 1765
             LR  +    K      E KEK++ +E  +   G  + E   + S  +  ++   E    
Sbjct: 1482 TLRRKLAALEKA-----EVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVE 1536

Query: 1766 IRLLEAQIATGGIIDPK----------ESHRLPVD---IAYKRGYFNEELSEILSDPSD- 1811
            +  LEA+++     + K          E+H+L ++   +  +      E++   ++  D 
Sbjct: 1537 VSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDL 1596

Query: 1812 --DTKGFFDPNTEENLTYLQLK----ERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKR 1865
               T      N +  L  L+ +    +R  KD++  +  L  +     V+  Q+    +R
Sbjct: 1597 RNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRR 1656

Query: 1866 RVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKT 1925
             +V++ P+T +E+S +EA++ GLID+  F +L  QEC+WEEI++ G +G + V+  DRK+
Sbjct: 1657 SIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVI-HDRKS 1715

Query: 1926 GSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMIS 1963
            G ++ I++A+  G +    +D+Y +  +S+ + A ++S
Sbjct: 1716 GKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVS 1753



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 21/85 (24%), Positives = 44/85 (51%), Gaps = 7/85 (8%)

Query: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120
            +IHP TG++LS ++A   G+ID +M  +L+  +     +E +  K     +  + ++   
Sbjct: 1660 VIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQE---CDWEEISVKGPNGESSVIHDR--- 1713

Query: 2121 YEAGQRFLEFQYLTGGLVDPEVHGR 2145
             ++G++F   + L  G + P  + R
Sbjct: 1714 -KSGKKFSIEEALQSGRLTPAQYDR 1737


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  132 bits (331), Expect = 5e-30
 Identities = 115/478 (24%), Positives = 212/478 (44%), Gaps = 56/478 (11%)

Query: 1437 RKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITG 1496
            +K L+  ++ ++LLE+Q    G+I P   E L+++  IAR+LI+    QQ+   + A+  
Sbjct: 2    QKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALAL 61

Query: 1497 FDDPFSGK-TVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLI 1555
                   +  +SV EAI+K +I    G+++LEA +A+GG     +   +  + A  +GLI
Sbjct: 62   ISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLI 121

Query: 1556 DRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIR 1615
               L+  L     + KN +DP T +K+  + L +RC +   +G  LL V++ +     ++
Sbjct: 122  SAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLK 181

Query: 1616 --QPVTVTELVDSGIL-RPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQK 1672
              + V++   V  G++ R  TV  LE+   +                   GI +  T  +
Sbjct: 182  SGRKVSIFRAVQEGLIDRQVTVRLLEAQLFA------------------GGIVDPRTGHR 223

Query: 1673 LGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLS 1732
            L + EA++  L+    A  +L  Q  TG I+D V+  RL ++EA    LV  +    +L 
Sbjct: 224  LTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILE 283

Query: 1733 AERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIA 1792
            +  +  G   PE+G I+ +  A+ +                   GI+  + +H++  +  
Sbjct: 284  SLWSFMGLLWPESGEILPITDALEQ-------------------GIVSTELAHKILSNRQ 324

Query: 1793 YKRGYFNEELSEILSDPSDDTKGFFDPNTEENL---------TYLQLKERCIKDEETGLC 1843
            + +  F    +EILS       G  D +   NL          ++QL +   ++   G  
Sbjct: 325  HIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAA 384

Query: 1844 LLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQE 1901
            +LP  +   +   SQ   L      +    T+  ++VQ   +  L+D E  + L  ++
Sbjct: 385  VLPCSKSHPKATASQSENL------LFQLMTHSYINVQNGQRLLLLDKELMETLTSRD 436



 Score =  123 bits (309), Expect = 2e-27
 Identities = 117/454 (25%), Positives = 207/454 (45%), Gaps = 46/454 (10%)

Query: 1428 EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQI 1487
            +K  L EA  + ++   + V L+E      G  D    E LT +  I   L+D      +
Sbjct: 744  QKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNV 803

Query: 1488 YAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKD 1547
              A+KAI+G  DP +    SV +A+   L+D+ET  R+LE Q+ +GG++D      +   
Sbjct: 804  LMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVT 863

Query: 1548 VALARGLID-RDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQK 1606
            +A   GL+D  D    +N  + S+    +   ++++  +Q++    I+P +   L  VQ 
Sbjct: 864  LASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQS 923

Query: 1607 RSMSFQGIRQPVTV--TELVDSGI------LRPSTVNELESGQISYDEVGERIKDFLQGS 1658
                     + V +   ++VD GI      +R S  N    G I  +++ E++K     +
Sbjct: 924  IDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIG-EDLAEKLKRV--EN 980

Query: 1659 SCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYK 1718
              I  I+N  TK+ + + +A+K+ L+      E+ E QA TG  VD +S  RL + EA K
Sbjct: 981  LNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKK 1040

Query: 1719 RGLV------------GI----------------EFKEKLLSAER--AVTGYNDPETG-- 1746
             GL+            GI                + K  + S +R   V  ++D + G  
Sbjct: 1041 EGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVS 1100

Query: 1747 -NIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEI 1805
              +++L QA+    ++    +++LEAQ  TGGIID     RL +  A +    +E +  I
Sbjct: 1101 DKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRI 1160

Query: 1806 LSDPSDDTKGFFDPNTEENLTYLQ-LKERCIKDE 1838
            ++       G  D  +++ +T ++ +++R I  E
Sbjct: 1161 IASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPE 1194



 Score =  118 bits (295), Expect = 8e-26
 Identities = 122/494 (24%), Positives = 213/494 (43%), Gaps = 69/494 (13%)

Query: 1663 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 1722
            GI++E T QKL + EA+  G+V   TA++L+E         D  +   L  EE    GL+
Sbjct: 736  GIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLM 795

Query: 1723 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 1782
              +    +L A++A++G  DP T  + S+  A+   L++K    R+LE Q+ TGGIID K
Sbjct: 796  DEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLK 855

Query: 1783 ESHRLPVDIAYKRGYFN--------------------EELSEILSDPSDDTKGFFDPNTE 1822
               ++ V +A   G  +                    + + E L     +T G  DP+++
Sbjct: 856  RGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSK 915

Query: 1823 ENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQE 1882
              LT +Q  +R + + E  + LL      KQV              I+   +   +SV  
Sbjct: 916  APLTVVQSIDRGLLEREEAVRLLT-----KQVVDGG----------IIHHISGMRLSVDN 960

Query: 1883 AYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDR 1942
            A++ GLI     ++L E+    E + I          + + +T     +  AI   L+  
Sbjct: 961  AFRHGLIG----EDLAEKLKRVENLNIHQ--------IFNPETKENISLPKAIKLDLITS 1008

Query: 1943 KFFDQYRSGSLSLTQFADMIS--------------LKNGVGTSSSMGSGVSDDVFSSSRH 1988
                + +        F D+IS              L N    S  M  G+ D        
Sbjct: 1009 DLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDP------- 1061

Query: 1989 ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2048
            E+   +     V+   I   S    LE   P + I D  + + +++++ I+ G VD  + 
Sbjct: 1062 ENCRIVPYSELVKKCKIDIESGQRYLEVI-PFSDIKDGVSDKVLTLSQAIQLGKVDFAST 1120

Query: 2049 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKM 2108
             ++LEAQA TGGII   TG++L+L  A+ + ++D++M   +   Q    G   +   +++
Sbjct: 1121 LKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRV 1180

Query: 2109 SAAEAVKEKWLPYE 2122
            +  EA++++ +  E
Sbjct: 1181 TLVEAIEKRLISPE 1194



 Score =  117 bits (292), Expect = 2e-25
 Identities = 98/413 (23%), Positives = 186/413 (45%), Gaps = 56/413 (13%)

Query: 1679 MKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVT 1738
            M+ GL+   T L LLE+Q     ++ P +   L +EE   R L+  +  ++L   + A+ 
Sbjct: 1    MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA 60

Query: 1739 GYND-PETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGY 1797
              +   E+   +S+ +A+ K +I +  G+++LEA +ATGG       + + ++ A+ +G 
Sbjct: 61   LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGL 120

Query: 1798 FNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTS 1857
             +  L  +L      +K   DPNT E +  L L +RCI  +E+G  LLP+K+        
Sbjct: 121  ISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGG---- 176

Query: 1858 QKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTR 1917
                       +V  ++ +++S+  A ++GLID +    L E +         G      
Sbjct: 177  -----------MVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQ------LFAGG----- 214

Query: 1918 VVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSG 1977
              +VD +TG +  +++A+   L+D+          L      D ++     G   ++   
Sbjct: 215  --IVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVT-----GQRLTIDEA 267

Query: 1978 VSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEG 2037
            VS+D+ +       +KI+ +                LE       +   E+ E + IT+ 
Sbjct: 268  VSNDLVA-------AKIALV---------------ILESLWSFMGLLWPESGEILPITDA 305

Query: 2038 IERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLK 2090
            +E+GIV +    ++L  +     +  P T + LS + A+  G++D+D+A  LK
Sbjct: 306  LEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLK 358



 Score =  108 bits (269), Expect = 8e-23
 Identities = 162/780 (20%), Positives = 303/780 (38%), Gaps = 73/780 (9%)

Query: 1421 GASASPKEK-YSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLI 1479
            G S SP E   +L EA  + LIS     +L      +  +IDP+  EK+ +   + R ++
Sbjct: 100  GFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIV 159

Query: 1480 DFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPV 1539
              +   ++   ++   G     SG+ VS+  A+++ LIDR+  +RLLEAQ+ +GG+VDP 
Sbjct: 160  HQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPR 219

Query: 1540 NSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGL 1599
                L  + A+   LID+D+  ++   +      +D VT ++++  +      +     L
Sbjct: 220  TGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIAL 279

Query: 1600 LLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSS 1659
            ++L   +   SF G+  P       +SG + P T + LE G +S  E+  +I   L    
Sbjct: 280  VIL---ESLWSFMGLLWP-------ESGEILPIT-DALEQGIVS-TELAHKI---LSNRQ 324

Query: 1660 CIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKR 1719
             I  ++   T + L   +A++ G++    A  L          V P   L    E+    
Sbjct: 325  HIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPD---VMPHMQLADSAEQNINP 381

Query: 1720 GLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGII 1779
            G         +L   ++       ++ N+  LFQ M    I   +G RLL         +
Sbjct: 382  GAA-------VLPCSKSHPKATASQSENL--LFQLMTHSYINVQNGQRLLLLDKELMETL 432

Query: 1780 DPKESHRLPVDIAYKRGYFNEELSEILSDPSD-DTKGFFDPNTEENLTYLQLKERCIKDE 1838
              ++ ++       + G+  ++  E L + ++    G F       L   Q   +  +  
Sbjct: 433  TSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYP 492

Query: 1839 ETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVD-PETNKEMSVQEAYKKGLIDY------ 1891
            +   C    K KK  V+T   +     + + V+  E N  +   +   K  ++       
Sbjct: 493  DREDCTTE-KGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIG 551

Query: 1892 -----ETFKELCEQECEWEEITITGSDGSTRVVLVDRKT--------------GSQYDIQ 1932
                 +T   + E       +TI  ++     ++VD+                 + +  Q
Sbjct: 552  TQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQ 611

Query: 1933 DAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVS 1992
            +     L      D+     +        + +K  +G    + S    +V    + E + 
Sbjct: 612  NEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLK 671

Query: 1993 KI-------STISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDS 2045
            K              +N+   S   S+  +E      IF       +S +  +E  +++ 
Sbjct: 672  KTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIF-------LSCSHPLE--LLEE 722

Query: 2046 ITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGK 2105
             T   +L AQ   GGI H  TGQKL L +A+S+G++    A +L      F GF   +  
Sbjct: 723  AT-LNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTC 781

Query: 2106 KKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRL 2165
            + ++  E + E  +  +     L       G++DP      S ++A+  G +D   A R+
Sbjct: 782  ESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRI 841



 Score =  101 bits (251), Expect = 1e-20
 Identities = 115/486 (23%), Positives = 209/486 (43%), Gaps = 56/486 (11%)

Query: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490
            S+ +A    L+  E+   +LE Q  TGGIID  R +K++V  A    L+D  D+ ++   
Sbjct: 823  SVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINL 882

Query: 1491 EKA--------------------ITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQI 1530
            EKA                     TG  DP S   ++V ++I + L++RE  +RLL  Q+
Sbjct: 883  EKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQV 942

Query: 1531 ASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFV-DPVTKKKVSYVQLKE 1589
              GG++  ++ + L  D A   GLI  DL   L    +   + + +P TK+ +S  +  +
Sbjct: 943  VDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIK 1002

Query: 1590 RCRIEPHTGLLLLSVQKRSMSFQGI--RQPVTVTELVDSGILRPSTVNELESGQISYDEV 1647
               I       +  VQ  + +F  +   Q +T+ E    G+L    V  L  G +     
Sbjct: 1003 LDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAV--LSPGMMH---- 1056

Query: 1648 GERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVS 1707
                   +   +C    Y+E  K+        KI +      LE++        I D VS
Sbjct: 1057 -----GIVDPENCRIVPYSELVKK-------CKIDIESGQRYLEVIPFSD----IKDGVS 1100

Query: 1708 NLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIR 1767
            +  L + +A + G V      K+L A+    G  D  TG  ++L  A+ ++L+++     
Sbjct: 1101 DKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRI 1160

Query: 1768 LLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILS-DPSDDTKGFFDPNTEENLT 1826
            +   Q+  GGI+D     R+ +  A ++   + EL+ ++  D S+ +        +E + 
Sbjct: 1161 IASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIE 1220

Query: 1827 YLQL------KERCIKDEETG-LCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPE---TNK 1876
               L      K+  I   +T  +    ++E ++  Q   ++   K +V + D E    ++
Sbjct: 1221 VCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSR 1280

Query: 1877 EMSVQE 1882
            E+S++E
Sbjct: 1281 EISLKE 1286



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 107/473 (22%), Positives = 194/473 (41%), Gaps = 83/473 (17%)

Query: 1741 NDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNE 1800
            ++ ++G  I L  +   EL+E+   + +L AQ+  GGI   +   +L ++ A  RG    
Sbjct: 701  DEEDSGREIFLSCSHPLELLEEAT-LNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPS 759

Query: 1801 ELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKN 1860
              +  L +  +  +GFFD  T E+LT  ++    + DE+                    N
Sbjct: 760  HTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKL-----------------LHN 802

Query: 1861 TLRKRRVV--IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRV 1918
             L   + +  ++DP T    SV++A   GL+D ET   + E++       +TG       
Sbjct: 803  VLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQ------VVTGG------ 850

Query: 1919 VLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGV 1978
             ++D K G +  +  A   GLVD                 AD   L N            
Sbjct: 851  -IIDLKRGKKVSVTLASTLGLVD----------------VADQPELIN------------ 881

Query: 1979 SDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGI 2038
               +  +S+     K          T+R    S  +E +     + D ++   +++ + I
Sbjct: 882  ---LEKASKGRDAEK----------TVRERLISLQMETT----GLIDPDSKAPLTVVQSI 924

Query: 2039 ERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFI- 2097
            +RG+++     RLL  Q   GGIIH  +G +LS+ +A   G+I +D+A +LK  +   I 
Sbjct: 925  DRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIH 984

Query: 2098 GFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFI 2157
                 + K+ +S  +A+K   +  +  +   E Q  TG  VD     R++  EA ++G +
Sbjct: 985  QIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLL 1044

Query: 2158 DGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVS 2210
               A      +      +  P+    + Y + + +  ++  +G R LE    S
Sbjct: 1045 TNEAVL----SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFS 1093



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 87/378 (23%), Positives = 168/378 (44%), Gaps = 42/378 (11%)

Query: 1832 ERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDY 1891
            ++ + D++TGL LL     + QV  S           ++ PET + +S++E   + LI+ 
Sbjct: 2    QKGLLDQDTGLVLL-----ESQVIMSG----------LIAPETGENLSLEEGIARNLINP 46

Query: 1892 ETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ--YDIQDAIDKGLVDR----KFF 1945
            + +++L E +                + L+ R T S+    + +AI+K ++      K  
Sbjct: 47   QMYQQLRELQ--------------DALALISRLTESRGPLSVVEAIEKRIISETVGLKIL 92

Query: 1946 DQY-RSGSLSLTQFADMISLKNGV--GTSSSMGSGVSDDVFSSSRH----ESVSKISTIS 1998
            + +  +G  SL+   + I+L+     G  S+    V +    +S++     +  KI  + 
Sbjct: 93   EAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLD 152

Query: 1999 SVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACT 2058
             ++   +   S    L        +   ++  K+SI   ++ G++D     RLLEAQ   
Sbjct: 153  LMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFA 212

Query: 2059 GGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKW 2118
            GGI+ P TG +L++++AV   +IDQDMA  +   Q    G       ++++  EAV    
Sbjct: 213  GGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDL 272

Query: 2119 LPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCP 2178
            +  +     LE  +   GL+ PE    +   +A+ +G +    A ++     + K L  P
Sbjct: 273  VAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLP 332

Query: 2179 KTKLKISYKDAINRSMVE 2196
             T   +S+K AI   +++
Sbjct: 333  ATTEILSWKKAIESGILD 350



 Score = 79.3 bits (194), Expect = 4e-14
 Identities = 57/204 (27%), Positives = 100/204 (49%), Gaps = 7/204 (3%)

Query: 1386 LIDKTTLDK-----LLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKL 1440
            LID  T +K     L++     +E   ++ P  + AG +    +    K S+  A ++ L
Sbjct: 139  LIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSG--RKVSIFRAVQEGL 196

Query: 1441 ISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDP 1500
            I  + TV LLEAQ   GGI+DP    +LTV+ A+  +LID D    I   +    G  D 
Sbjct: 197  IDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDT 256

Query: 1501 FSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLY 1560
             +G+ +++ EA+  +L+  +  + +LE+  +  G++ P +   LP   AL +G++  +L 
Sbjct: 257  VTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELA 316

Query: 1561 RSLNDPRDSQKNFVDPVTKKKVSY 1584
              +   R   K    P T + +S+
Sbjct: 317  HKILSNRQHIKALFLPATTEILSW 340



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 49/168 (29%), Positives = 84/168 (50%), Gaps = 1/168 (0%)

Query: 2038 IERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFI 2097
            +++G++D  TG  LLE+Q    G+I P TG+ LSL++ +++ +I+  M  +L+  Q A  
Sbjct: 1    MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALA 60

Query: 2098 GFEGV-KGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGF 2156
                + + +  +S  EA++++ +    G + LE    TGG         I+ EEA  +G 
Sbjct: 61   LISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGL 120

Query: 2157 IDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204
            I       L+     +K L  P T  KI   D + R +V   +G +LL
Sbjct: 121  ISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLL 168



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 87/414 (21%), Positives = 170/414 (41%), Gaps = 58/414 (14%)

Query: 1755 MNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTK 1814
            M K L+++  G+ LLE+Q+   G+I P+    L ++    R   N ++ + L +   D  
Sbjct: 1    MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRE-LQDAL 59

Query: 1815 GFFDPNTEEN--LTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDP 1872
                  TE    L+ ++  E+ I  E  GL +L     +  + T   +         + P
Sbjct: 60   ALISRLTESRGPLSVVEAIEKRIISETVGLKIL-----EAHLATGGFS---------LSP 105

Query: 1873 ETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQ 1932
              N  ++++EA+ +GLI              W   ++  S   T   L+D  T  +  + 
Sbjct: 106  SENC-INLEEAFHQGLIS------------AWLH-SVLESYLRTSKNLIDPNTAEKIGLL 151

Query: 1933 DAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVS 1992
            D + + +V ++      SG         ++ +K   G   S+ SG    +F + +   + 
Sbjct: 152  DLMQRCIVHQE------SGF-------KLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLID 198

Query: 1993 KISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLL 2052
                    R +T+R       LE       I D     ++++ E +   ++D      +L
Sbjct: 199  --------RQVTVR------LLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAIL 244

Query: 2053 EAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAE 2112
              Q  TGGII   TGQ+L++ +AVS  ++   +A  +  +  +F+G    +  + +   +
Sbjct: 245  IRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITD 304

Query: 2113 AVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQ 2166
            A+++  +  E   + L  +     L  P     +S ++AI  G +D   A  L+
Sbjct: 305  ALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLK 358



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 61/296 (20%), Positives = 133/296 (44%), Gaps = 12/296 (4%)

Query: 1380 QLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKK 1439
            Q++  +  +  +L K +K      ++  EIQ      G+     +   ++ +L EAK++ 
Sbjct: 985  QIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISG--QRLTLAEAKKEG 1042

Query: 1440 LISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDD 1499
            L++ E+ +    +     GI+DP     +     + +  ID +  Q+ Y      +   D
Sbjct: 1043 LLTNEAVL----SPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQR-YLEVIPFSDIKD 1097

Query: 1500 PFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDL 1559
              S K +++S+AI+   +D  + +++LEAQ  +GG++D      L    AL   L+D ++
Sbjct: 1098 GVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENM 1157

Query: 1560 YRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVT 1619
             R +   +      VD  + ++V+ V+  E+  I P    L   +Q  S  F   R  + 
Sbjct: 1158 VRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPE---LANMIQIDSSEFSDHRAQIE 1214

Query: 1620 VTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGI 1675
              E ++   L+   +   +   I+ ++  E   + ++ S  +  + N++ ++K+ +
Sbjct: 1215 KQEGIEVCALQNEFLG--KDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKV 1268



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 186/967 (19%), Positives = 376/967 (38%), Gaps = 155/967 (16%)

Query: 415  LEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQK 474
            L+Q++ L+ E +K L+  ++ ++ + +S+K ++   +        P +L+    + +D  
Sbjct: 2309 LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV- 2367

Query: 475  IVHKGDECILKDNNER----SKWYVTG--PGGVDMLVPSVGLIIPPPNPLAVDLSC-KIE 527
            I HKGD   +  + ++       +  G  P  +  LV    L        A+   C ++ 
Sbjct: 2368 ISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK-LKDATERYTALHSKCTRLG 2426

Query: 528  QYYEAILALWNQLYINMKSLVSW-HYCMIDIEKIRAMTIAKLKTMRQEDYMKT------I 580
             +   +L  ++Q   +  SL +W   C  ++EK+ + T+A    + QE    T      +
Sbjct: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486

Query: 581  ADLEL---HYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTT 637
            A+ ++     Q+  R+    E     D R +Q        H+Q+L   L    +  ++  
Sbjct: 2487 AEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA---ERSSLLQ 2543

Query: 638  TEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQG 697
              I    + Q+   + +          E   +  L     Q E     M LK   +A Q 
Sbjct: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQ-EALATNMKLKQ-DIARQK 2601

Query: 698  SSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKL---- 753
            SS   T ++        DS   A +  +L ++   F   E+ C  Q E     +KL    
Sbjct: 2602 SSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRF---EQLCLQQQEKESSLKKLLPQA 2658

Query: 754  ---ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCG 810
               E+++G    ++ +    R L       +D+   ++              +++     
Sbjct: 2659 EMFEHLSGKLQQFMENKS--RMLASGNQPDQDITHFFQ--------------QIQELNLE 2702

Query: 811  LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRI 870
            ++  + +L+  + L+    TEL                + LDL +  ++V  L   +  +
Sbjct: 2703 MEDQQENLDTLEHLV----TELSSCG------------FALDLCQHQDRVQNLRKDFTEL 2746

Query: 871  DKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQ 930
             K +  R  D     +QL  +R   + F KWL + +      E+     +  + + +   
Sbjct: 2747 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSM--SAKELEKQIEHL 2804

Query: 931  KNLHSEISGKRDKSEEVQKIAELC-ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPS 989
            K+L  + + K    EE+      C   S+++  +++ +  S  +T   +P   + + S +
Sbjct: 2805 KSLLDDWASKGTLVEEIN-----CKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2859

Query: 990  GV--------ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL-KLKNTKIEVLE-- 1038
            G         I  + +DV+ +Y +L     +    L  +L  +E++ K  N+ ++ LE  
Sbjct: 2860 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2919

Query: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLD 1098
            EE+  + DA S             +  +A+    KA LA LE              QN  
Sbjct: 2920 EEVLKSMDAMSS--------PTKTETVKAQAESNKAFLAELE--------------QNSP 2957

Query: 1099 KCYGQIKELNEKITRL--TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG-- 1154
            K    I+++ E +  L  TY    E    K +++  + +     ++  ARQ + E     
Sbjct: 2958 K----IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 3013

Query: 1155 ---WQKLESEKA--IKEKEYEI-----------------ERLRVLLQEEGTRKREYE--N 1190
               +Q  ES+    + EKE  +                 ++++ +L+E   R++++E  N
Sbjct: 3014 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLN 3073

Query: 1191 ELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
            E A+         +  T  VQ         K L+    +   L D+LN   S ++ +  V
Sbjct: 3074 EAAQGILTGPGDVSLSTSQVQ---------KELQSINQKWVELTDKLNSRSSQID-QAIV 3123

Query: 1251 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSER---EKNSLRSEIERLQAEI 1307
            K     + Q++  DL++      ++      I ++ E  ++   E + +RS++E+L  E+
Sbjct: 3124 KST---QYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180

Query: 1308 KRIEERC 1314
            K  +  C
Sbjct: 3181 KEAQTLC 3187



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 136/746 (18%), Positives = 280/746 (37%), Gaps = 127/746 (17%)

Query: 709  LKSVQNDSQAIAEVLNQLKDMLANFRGS---EKYCYLQNEVFGLFQKLENINGVTDGYLN 765
            L  ++ +S  I +V   L  +L  +  S   E +  +Q E+   +++   +       L 
Sbjct: 2949 LAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLE 3008

Query: 766  SLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 825
               +  A  QA    E  L+ +   L E+E +   L         L    N LN +K  +
Sbjct: 3009 ESASHLACFQA---AESQLRPW---LMEKELMMGVLGP-------LSIDPNMLNAQKQQV 3055

Query: 826  ATMKTELQKAQQIHSQTSQQYPLY-------DLDLGKFGEKVTQLTDRWQRIDKQIDFRL 878
              M  E +  +Q H Q ++             L   +  +++  +  +W  +  +++ R 
Sbjct: 3056 QFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRS 3115

Query: 879  WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
              +++ I +   Y++  Q   + +    +R  S++S        V + L E   + S++ 
Sbjct: 3116 SQIDQAIVKSTQYQELLQDLSEKVRAVGQRL-SVQSAISTQPEAVKQQLEETSEIRSDLE 3174

Query: 939  GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
                + +E Q + +  +  I +  L+       LET          +  P   +   AAD
Sbjct: 3175 QLDHEVKEAQTLCDELSVLIGEQYLK-DELKKRLET----------VALPLQGLEDLAAD 3223

Query: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL 1058
               R    L  +  + +   E+   L+D + +  K   +  +L   +    EN    K L
Sbjct: 3224 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSL 3283

Query: 1059 DQNLQKYQAECSQFKAKLAS-------------LEELKRQ-AELDGKSAKQN-------- 1096
            +Q+   Y+   ++ ++ L S             L ELK    EL  K+A +         
Sbjct: 3284 NQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ 3343

Query: 1097 ---------------LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQ 1141
                           ++ C  ++ EL  ++T    ++E    R K++ +  +++++  + 
Sbjct: 3344 KAQKYQWHVEDLVPWIEDCKAKMSEL--RVTLDPVQLESSLLRSKAMLNEVEKRRSLLEI 3401

Query: 1142 LQKAR-------QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194
            L  A        + +++ +  +K    + +     E++     L+E   R RE++     
Sbjct: 3402 LNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKN 3461

Query: 1195 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR---LQRLEDE--------------- 1236
               +++ +K+Q  ++     S     K LE+ +A+   LQ LE +               
Sbjct: 3462 IEKKVEGAKHQL-EIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA 3520

Query: 1237 ---------LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE 1287
                     L++A+   +    VKQR+      ++N L      + R  E   ++    +
Sbjct: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580

Query: 1288 KSE------REKNSLRSEIER----------LQAEIKRIEERCRRKLEDSTRETQSQLET 1331
            + +      R+ +SL+S+IE           L+ +I+  E  CR  LE+        L+ 
Sbjct: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKR 3640

Query: 1332 ERSRYQREIDKLRQRPYGSHRETQTE 1357
            E     ++  KL +R  G  R+ Q E
Sbjct: 3641 ELEALNKQCGKLTER--GKARQEQLE 3664



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 113/609 (18%), Positives = 251/609 (41%), Gaps = 84/609 (13%)

Query: 738  KYCYLQNEVFGLFQKLENINGVTDGYLNSLC-----TVRALLQAILQT-EDMLKVYEARL 791
            K+  L+N+V      +E +N   +  L S       ++R+ L+A+ Q  E +L+  E R 
Sbjct: 4809 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4868

Query: 792  TEEETVCLDLD----KVEAYRCGLKKIKNDLNLKK---SLLATMKTELQKAQQIHSQTSQ 844
             + ++          ++E +   L ++++ L+  K    L  T + +L    +++SQ   
Sbjct: 4869 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKA 4928

Query: 845  QYPLYD--LDLGKF----------GEKVTQ----LTDRWQRIDKQIDFRLWDLEKQIKQL 888
            +   Y+  LD G+           G K  Q    L  +W  +  +++ R   LE+ +   
Sbjct: 4929 KEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLA 4988

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
              ++++ Q F  WL  A++   ++ S      NTV+  + E K   +E++  RD+  E+ 
Sbjct: 4989 TEFQNSLQEFINWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 5047

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
            +            +L+  S    +  + N+ +    +QS    ++Q + +      +   
Sbjct: 5048 QTGN---------QLKFLSQKQDVVLIKNLLVS---VQSRWEKVVQRSIERGRSLDDARK 5095

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN--SENCNKNKFLDQNLQKYQ 1066
            R+  ++    +++  LED +        L+ EL ++ D +      +K+K   + L   Q
Sbjct: 5096 RAKQFHEAWKKLIDWLEDAE------SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQ 5149

Query: 1067 AECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK 1126
                 +   + +   LK +  L   S  Q LD   G++++  + +   + E      R+ 
Sbjct: 5150 ---PVYDTTIRTGRALKEKTLLPEDS--QKLDNFLGEVRDKWDTVCGKSVE------RQH 5198

Query: 1127 SVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAIKEKEYEIERLRVLLQEEGTRK 1185
             +E+         D LQ         + W  K+E + A  +  +    L + L +     
Sbjct: 5199 KLEEALLFSGQFMDALQAL-------VDWLYKVEPQLAEDQPVHGDLDLVMNLMD---AH 5248

Query: 1186 REYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNR-AKSTL 1244
            + ++ EL K +  +Q  K    ++++        +      K +LQ L    +   K ++
Sbjct: 5249 KVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWV------KGQLQELSTRWDTVCKLSV 5302

Query: 1245 EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ 1304
              ++R++Q L+ + +  ++ ++      S  E+ +R     R     +  +L+S I+  +
Sbjct: 5303 SKQSRLEQALK-QAEVFRDTVHMLLEWLSEAEQTLR----FRGALPDDTEALQSLIDTHK 5357

Query: 1305 AEIKRIEER 1313
              +K++EE+
Sbjct: 5358 EFMKKVEEK 5366



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 116/579 (20%), Positives = 238/579 (41%), Gaps = 51/579 (8%)

Query: 858  EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            + + ++ + W+ ++K    RL  LE  ++    Y+D  QA   WL +   +  ++  +  
Sbjct: 4629 KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG- 4687

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC---ANSIKDYELQLASYTSGLET 974
             D NTV   LNE K    E+  ++ + E++    EL    A    D ++     T     
Sbjct: 4688 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHL 4747

Query: 975  LLNIPIKRTMIQSP-SGVILQEAADVHA--RYIELLTRSGDYYRFLSEMLKSLEDLKLKN 1031
              N+  K    Q    G +L      HA    +  LT + +       +    + ++++ 
Sbjct: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVEL 4807

Query: 1032 TKIEVLEEELRLARDANSENCNK--NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
             K  VL+ ++ LA  A  E  NK  N+ L+ +      + S  +++L ++ +        
Sbjct: 4808 AKHHVLKNDV-LAHQATVETVNKAGNELLESSAGD---DASSLRSRLEAMNQC------- 4856

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
             +S  Q  ++   Q++   ++      EIED       +E +    K      + AR+  
Sbjct: 4857 WESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQL 4916

Query: 1150 KENLGWQKLESEKAIKEKEY----EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQ 1205
              ++   +L S+   KE+ Y    +  RL +L +++     + E  +A     +++  + 
Sbjct: 4917 DTHM---ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVA----LLEQKWHV 4969

Query: 1206 CTQVVQERESLLVK-IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQ-- 1262
             +  ++ER+S L + + +  + +  LQ   + L  A+ +L   +     L     QI+  
Sbjct: 4970 VSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEH 5029

Query: 1263 ----NDLNQWKTQYSRKEEAIRKIE--SEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1316
                N++N  + Q    ++   +++  S+++     KN L S   R +  ++R  ER  R
Sbjct: 5030 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIER-GR 5088

Query: 1317 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376
             L+D+ +  +   E     +++ ID L      +     +E E + D  K+     + K 
Sbjct: 5089 SLDDARKRAKQFHEA----WKKLIDWLED----AESHLDSELEISNDPDKIKLQLSKHKE 5140

Query: 1377 TAMQLYECQLIDKTTL--DKLLKGKKSVEEVASEIQPFL 1413
                L   Q +  TT+   + LK K  + E + ++  FL
Sbjct: 5141 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 106/513 (20%), Positives = 197/513 (38%), Gaps = 81/513 (15%)

Query: 801  LDKVEAYRCGLKKIKNDLNLKKSLLATMK---TELQKAQQIHSQTSQQYPLY------DL 851
            LD      C +  +  DLN  K  L  MK    E+ + Q    + + Q  L       + 
Sbjct: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4732

Query: 852  DLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS 911
            D     E +T+L   W+ + ++I  R   LE  +  L  ++   +    WL   +   D+
Sbjct: 4733 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDA 4792

Query: 912  LESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIA-ELCANSIKDYELQLASYTS 970
               +  GD   +   L +   L +++   +   E V K   EL  +S  D    L S   
Sbjct: 4793 QRPIS-GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4851

Query: 971  GLETLLNIPIKRT-----MIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLE 1025
             +       +++T      +QS     LQ+A   H+                      +E
Sbjct: 4852 AMNQCWESVLQKTEEREQQLQS----TLQQAQGFHS---------------------EIE 4886

Query: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEEL--K 1083
            D  L+ T+   +E +L  ++          + LD +++ Y    SQ KAK  +  +L  K
Sbjct: 4887 DFLLELTR---MESQLSASKPTGGLPETAREQLDTHMELY----SQLKAKEETYNQLLDK 4939

Query: 1084 RQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQ 1143
             +  L  +    +  K    +  L +K   ++ ++E+ K        + ++  N   + Q
Sbjct: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK-------SKLEEALNLATEFQ 4992

Query: 1144 KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI---Q 1200
             + Q   E + W  L  +         +    VL Q E    + + NE+    ++I    
Sbjct: 4993 NSLQ---EFINWLTLAEQSLNIASPPSLILNTVLSQIE--EHKVFANEVNAHRDQIIELD 5047

Query: 1201 ESKNQCTQVVQERESLLVK----------IKVLEQDKARLQRLEDELNRAKSTLEAETRV 1250
            ++ NQ   + Q+++ +L+K           KV+++   R + L+D   RAK   EA  ++
Sbjct: 5048 QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKL 5107

Query: 1251 KQRLECEKQ------QIQNDLNQWKTQYSRKEE 1277
               LE  +       +I ND ++ K Q S+ +E
Sbjct: 5108 IDWLEDAESHLDSELEISNDPDKIKLQLSKHKE 5140



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 113/627 (18%), Positives = 238/627 (37%), Gaps = 78/627 (12%)

Query: 850  DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
            D D+      + ++  RW  ++K++  R+  L++ +     ++D  +    WL D +   
Sbjct: 3743 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3802

Query: 910  DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969
             + +     +   V   + EQK L   +  ++   + +Q      A S      +LA   
Sbjct: 3803 AN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS-----AELADRE 3856

Query: 970  SGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL 1029
                 L ++  + T + S +    ++  D+     +    +     FLS   K L + + 
Sbjct: 3857 KITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP 3916

Query: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELD 1089
              T+   +++++            ++K L+++++ +  +  Q      SL  L   AE  
Sbjct: 3917 VGTQTAKIQQQI-----------IRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE-- 3963

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR--- 1146
                        G + E  + +     EI+D   R+ ++ D+          L  AR   
Sbjct: 3964 -----------QGVLSEKIDSLQARYSEIQDRCCRKAALLDQ---------ALSNARLFG 4003

Query: 1147 QCEKENLGWQKLESEK--AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204
            + E E L W     +K  ++  K+++ + L     +      E  N        I+  + 
Sbjct: 4004 EDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQA 4063

Query: 1205 QCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1264
               Q   E E LL++ K L+  K R   +    ++A  TLE   ++  + +   +++   
Sbjct: 4064 LLKQTTGE-EVLLIQEK-LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW 4121

Query: 1265 LNQWKTQ------YSRKEEAIRKIESEREKSEREKNSLR------SEIERLQAEIK--RI 1310
            L + + +       S   E I + +  +++ ++E    R      +E+ R   E+   R 
Sbjct: 4122 LREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRA 4181

Query: 1311 EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTS-KLVF 1369
             E   + + D+  + +   +T   R   EID   QR     +    E  W  +T  KL+ 
Sbjct: 4182 REGLDKLVSDANEQYKLVSDTIGQRVD-EIDAAIQRSQQYEQAADAELAWVAETKRKLMA 4240

Query: 1370 DG---LRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASP 1426
             G   L +  T  QL     + K     +++ K S++E+ S         G         
Sbjct: 4241 LGPIRLEQDQTTAQLQ----VQKAFSIDIIRHKDSMDELFSHRSEIFGTCG--------- 4287

Query: 1427 KEKYSLVEAKRKKLISPESTVMLLEAQ 1453
            +E+ ++++ K + LI     + LL ++
Sbjct: 4288 EEQKTVLQEKTESLIQQYEAISLLNSE 4314



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 96/522 (18%), Positives = 195/522 (37%), Gaps = 93/522 (17%)

Query: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918
            ++ +L + W+ + K+   R   L+  +++ + Y+ + +    W+ D K +   L      
Sbjct: 3316 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-- 3373

Query: 919  DSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNI 978
            D   +   L   K + +E+  +R   E +   A++  NS +  E  +    +G+      
Sbjct: 3374 DPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGIN----- 3428

Query: 979  PIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLE 1038
                               ++ A   EL  ++G        + +  E  K    K+E  +
Sbjct: 3429 ------------------QNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 3470

Query: 1039 EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR------QAELDGKS 1092
             +L +     S+ C+     ++NL+K +A+    +A    ++ L+       +   DG  
Sbjct: 3471 HQLEIFDALGSQACS-----NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSD 3525

Query: 1093 AKQNLDKC------YGQIKE-LNEKITRLTYEIEDEKRRRKSVEDRFDQQKN-------- 1137
            A Q L +       + ++K+ +N     +  ++E   +    V + F Q  +        
Sbjct: 3526 ASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGM 3585

Query: 1138 -----DYDQLQKARQCEKENLGWQKLESEKA-IKEKEYEIERLRVLLQEEGTRKREYENE 1191
                 D D LQ   Q E   L   K+   K  I+  E E    R +L+EEGT       +
Sbjct: 3586 GAIGRDTDSLQS--QIEDVRLFLNKIHVLKLDIEASEAE---CRHMLEEEGTL------D 3634

Query: 1192 LAKASNRIQESKNQCTQVVQ----ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1247
            L      ++    QC ++ +     +E L + +  +E    +L+ L D    A+     +
Sbjct: 3635 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQ 3694

Query: 1248 TRVKQRLECEKQQIQ--------------------NDLNQWKTQYSRKEEAIRKIESERE 1287
              V   +E   QQ+                     N L Q   Q + K+  ++ +E + E
Sbjct: 3695 WVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME 3754

Query: 1288 KSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL 1329
            +     N+L  ++ +  A+++     C  K +D+     S L
Sbjct: 3755 EINARWNTLNKKVAQRIAQLQEALLHC-GKFQDALEPLLSWL 3795



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 74/411 (18%), Positives = 159/411 (38%), Gaps = 57/411 (13%)

Query: 1060 QNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEI- 1118
            +N++    +    +  LA L++L  QA++  +  K        +++ +N+ I     E+ 
Sbjct: 1818 RNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVP 1877

Query: 1119 --------EDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
                    +D K  +KS+    D   +     Q A + EK  +  Q  + E  +++    
Sbjct: 1878 AQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAW 1937

Query: 1171 IERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK--------- 1221
            +    ++L  +G+      + L     + ++ K    +   + ++L   I+         
Sbjct: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997

Query: 1222 ----------------------VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ 1259
                                  +LEQ  A++  L+  L + +     +T  KQ+  C +Q
Sbjct: 1998 LSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQ 2057

Query: 1260 QIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCR---R 1316
                DL  W  Q  R     +   ++++ S  +KN  +S+++ LQ +I+          +
Sbjct: 2058 --LEDLCSWVGQAERALAGHQGRTTQQDLSALQKN--QSDLKDLQDDIQNRATSFATVVK 2113

Query: 1317 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWT----VDTSKLVFDGL 1372
             +E    E Q++L        RE+  LR++ + +  + +   E T     +  + V   L
Sbjct: 2114 DIEGFMEENQTKLS------PRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 2167

Query: 1373 RKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGAS 1423
            +++    +  +    +K  +D LL    SV     ++   L G   ++GAS
Sbjct: 2168 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGAS 2218



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 142/777 (18%), Positives = 282/777 (36%), Gaps = 146/777 (18%)

Query: 743  QNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLD 802
            Q E   L + L+         L  LC+       + Q E  L  ++ R T++     DL 
Sbjct: 2037 QMEQEALVKTLQKQQNTCHQQLEDLCSW------VGQAERALAGHQGRTTQQ-----DLS 2085

Query: 803  KVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQ 862
             ++  +  LK +++D+  + +  AT+  +++   +       Q  L   +L    EK+ Q
Sbjct: 2086 ALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFME-----ENQTKLSPRELTALREKLHQ 2140

Query: 863  LTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNT 922
              ++++ + ++      +LE+ +              K L + K++ D+L        ++
Sbjct: 2141 AKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSS 2200

Query: 923  VMRFLN-----EQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLN 977
              + L      EQ +  S   G  D ++    + +      K  E+  A +   L    N
Sbjct: 2201 GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQN 2260

Query: 978  IPIKRTMIQS------------PSGVILQEAADVHARYIELLTRSGDYYRFLS----EML 1021
              +     Q+               ++ Q+  ++  +Y   L +S    + +     E+ 
Sbjct: 2261 FILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQ 2320

Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
            K L+D K   + +E  E+EL        EN +K     + L         F   + S + 
Sbjct: 2321 KFLQDHKEFESWLERSEKEL--------ENMHKGGSSPETLPSLLKRQGSFSEDVISHKG 2372

Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---------- 1131
              R   + G+    +++  + + KE +E    +  +++D   R  ++  +          
Sbjct: 2373 DLRFVTISGQKVL-DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNM 2431

Query: 1132 ----FDQQKNDYDQLQKARQ-CE------------------KENLGWQKLESEKAIKEKE 1168
                + Q +N  D LQ   Q CE                  +E L   K + ++ + E +
Sbjct: 2432 LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK-QLQEELAEHQ 2490

Query: 1169 YEIERL----RVLLQEEGTRKREYEN-----------------ELAKASNRIQESKNQCT 1207
              +E+L    R +++ EG    ++ +                  LA+ S+ +Q++  Q  
Sbjct: 2491 VPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQ 2550

Query: 1208 QVVQERESLLVKIKVLEQD-----------------KARLQRLEDELNRAKSTLEAETRV 1250
             V +  ESLL  I  +EQ+                  A   +L+ ++ R KS+LEA   +
Sbjct: 2551 SVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM 2610

Query: 1251 KQR-LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR 1309
              R +E         L     + S++ E +   + E+E S ++        E L  ++++
Sbjct: 2611 VTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQ 2670

Query: 1310 IEERCRRKLEDSTRETQ---------SQLETERSRYQREIDKLRQRPYGSHRETQ-TECE 1359
              E   R L    +  Q          +L  E    Q  +D L       H  T+ + C 
Sbjct: 2671 FMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL------EHLVTELSSCG 2724

Query: 1360 WTVDTSKLV--FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLR 1414
            + +D  +       LRK  T +Q          T+ +  K   S +E   E +  +R
Sbjct: 2725 FALDLCQHQDRVQNLRKDFTELQ---------KTVKEREKDASSCQEQLDEFRKLVR 2772



 Score = 39.7 bits (91), Expect = 0.034
 Identities = 28/68 (41%), Positives = 36/68 (52%), Gaps = 4/68 (5%)

Query: 2208 SVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGS----FDATGNSSYSYSY 2263
            S SS    +    + A   +S SR GSR+GSR+GSR+ SRRGS    FD     S     
Sbjct: 5838 SNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDT 5897

Query: 2264 SFSSSSIG 2271
            S SS++ G
Sbjct: 5898 SESSAAGG 5905



 Score = 32.3 bits (72), Expect = 5.4
 Identities = 34/168 (20%), Positives = 70/168 (41%), Gaps = 14/168 (8%)

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            LQA++   D L   E +L E++ V  DLD V       K  + +L  +   +  +K   +
Sbjct: 5214 LQALV---DWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK---R 5267

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
              +++   +         D      ++ +L+ RW  + K    +   LE+ +KQ   +RD
Sbjct: 5268 SGRELIENSRD-------DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRD 5320

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
                  +WL +A++      ++   D+  +   ++  K    ++  KR
Sbjct: 5321 TVHMLLEWLSEAEQTLRFRGALP-DDTEALQSLIDTHKEFMKKVEEKR 5367


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  106 bits (265), Expect = 2e-22
 Identities = 244/1201 (20%), Positives = 480/1201 (39%), Gaps = 170/1201 (14%)

Query: 213  SVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQ-----LEEEYENLLKASFERMD 267
            SV +  ++H+ +  S  +Y  +++ +K +L    + Y      L+++ E  +    E  +
Sbjct: 109  SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSE 168

Query: 268  HLRQLQNI---IQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVK-- 322
             L+   N    ++    EI  I    EE++LY     +    +K+E  +   + +E    
Sbjct: 169  QLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQ 228

Query: 323  --EKELNKLKQESDQL-VLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYF 379
              +K +N L++E  QL  ++Q    +        L  Q          I+   KE+ A  
Sbjct: 229  HYQKNINSLQEELLQLKAIHQEEVKE--------LMCQ----------IEASAKEHEAEI 270

Query: 380  QFFEEA-QSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREK---ILEYKRQV 435
                E  ++     +  + +I+KKY C+    L++L +      ++ +    +L+    V
Sbjct: 271  NKLNELKENLVKQCEASEKNIQKKYECE----LENLRKATSNANQDNQICSILLQENTFV 326

Query: 436  QNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDN--NERSKW 493
            + +VN+  K+  L+    +  S   I L+    Y  + K+  + D   +KD   +ER   
Sbjct: 327  EQVVNE--KVKHLEDTLKELESQHSI-LKDEVTYMNNLKLKLEMDAQHIKDEFFHERE-- 381

Query: 494  YVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYC 553
                    D+      L++        +  C IE+    +  L  Q            +C
Sbjct: 382  --------DLEFKINELLLAKE-----EQGCVIEKLKSELAGLNKQ------------FC 416

Query: 554  MIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFT 613
                +  R +   K      E + K I++L    + F+ +S+  ++    + + ++ Q  
Sbjct: 417  YTVEQHNREVQSLK------EQHQKEISELN---ETFLSDSEKEKLTLMFEIQGLKEQCE 467

Query: 614  DAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQ 673
            + Q+  Q  ++      +   +  TE+            K+ +      +Q+   + ELQ
Sbjct: 468  NLQQEKQEAILNYESLREIMEILQTELGESA-------GKISQEFESMKQQQASDVHELQ 520

Query: 674  -KIRRQIEHCEGRMTLKNLPLADQG---SSHHITVKI-NELKSVQNDSQAIAEVLNQLKD 728
             K+R      +  +   N    +     S   +  ++ N +K++Q  +      L+Q   
Sbjct: 521  QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580

Query: 729  MLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYE 788
            ML    G  K   L  E      KL+N +   D +         L+  + +  +    Y 
Sbjct: 581  MLKELEG--KINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYN 638

Query: 789  ARLTEEETVCLDLDKVEAYRCGLK-----KIKNDLNLKKSLLATMKTELQKAQQIHSQTS 843
            + L +         KV     GL+     K +ND  L+K L+  MK   +  + + ++  
Sbjct: 639  SELEQ---------KVNELTGGLEETLKEKDQNDQKLEK-LMVQMKVLSEDKEVLSAEVK 688

Query: 844  QQYPLYDLDLGKFGEKVTQLTDRW-----QRIDKQIDFRLWDLEKQIKQLRNYRDNYQAF 898
              Y     +  K   +  QL+        Q+ D  +   +  LEK+++ +   +DN    
Sbjct: 689  SLYE----ENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLN-- 742

Query: 899  CKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSI 958
             K L + + ++  +++  +G       FL E  +  SE S ++D    +Q + E  A  I
Sbjct: 743  -KLLENEQVQKLFVKTQLYG-------FLKEMGSEVSEDSEEKDVVNVLQAVGESLAK-I 793

Query: 959  KDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIE---LLTRSGDYYR 1015
             + +  LA      E +L +  +   +Q  S V  +E   +   Y +   LL +  +  +
Sbjct: 794  NEEKCNLAFQRD--EKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQ 851

Query: 1016 FLSEMLKS-LEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKA 1074
               E L+S L ++K  N K  +  + L +  +  S+ C+K++  ++  + +  E    K 
Sbjct: 852  SEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKP 911

Query: 1075 KLASLEELKRQAELD------GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSV 1128
             L   E   R+AEL        KS     D     +KEL EKI  L  E ++++ +   +
Sbjct: 912  LLEQKELRDRRAELILLKDSLAKSPSVKNDPL-SSVKELEEKIENLEKECKEKEEKINKI 970

Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEK---------------AIKEKEYEIER 1173
            +    + K + D  +K  Q  KE L  + L SEK               + K    E E+
Sbjct: 971  KLVAVKAKKELDSSRKETQTVKEEL--ESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK 1028

Query: 1174 LRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRL 1233
                L  E  R   +E+ +   + +++ S  QC  +  + E LL +I+ L+ +   L+  
Sbjct: 1029 QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088

Query: 1234 EDELNRAKS----TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESERE-- 1287
              E+ RAK+     LEAE   K++   E     N+L + + Q  ++++ ++K   E E  
Sbjct: 1089 ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148

Query: 1288 KSEREKNSLR----SEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1343
            K + ++ +L     ++ ERL  E+ +       K+ED  +E + Q + + +  Q EI  L
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQET-LQEEITSL 1207

Query: 1344 R 1344
            +
Sbjct: 1208 Q 1208



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 190/1078 (17%), Positives = 448/1078 (41%), Gaps = 166/1078 (15%)

Query: 243  REKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKN 302
            ++ S +++L+++    L+ +F   D L +  N +Q  + +++      ++EL+ +  +  
Sbjct: 511  QQASDVHELQQK----LRTAFTEKDALLETVNRLQGENEKLL-----SQQELVPELENTI 561

Query: 303  TNIAQKQEAFSIRMSQLEVKEKEL----NKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
             N+ +K   + + +SQ +   KEL    N L +E D  +     + ++++ +    + + 
Sbjct: 562  KNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREE 621

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
              IL++ K ++  ++ N+      E  Q       GL++++++K   D+   L+ L+ Q+
Sbjct: 622  RLILELGKKVEQTIQYNS------ELEQKVNELTGGLEETLKEKDQNDQK--LEKLMVQM 673

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            K L +++E +             S ++  L   N    S K  + R L      +  + +
Sbjct: 674  KVLSEDKEVL-------------SAEVKSLYEENNKLSSEKKQLSRDL------EVFLSQ 714

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
             ++ ILK++             +  L   + L++   +    +L+  +E      L +  
Sbjct: 715  KEDVILKEH-------------ITQLEKKLQLMVEEQD----NLNKLLENEQVQKLFVKT 757

Query: 539  QLYINMKSLVSW------HYCMIDIEKIRAMTIAKLKT-------MRQEDYMKTIADLE- 584
            QLY  +K + S          ++++ +    ++AK+          R E  ++   +++ 
Sbjct: 758  QLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKC 817

Query: 585  LHYQEFIRNSQGSEMFGDDDKRKI--QSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITH 642
            L  +  ++  +   +  D ++ K+  + +  + Q   + L   L         T  E   
Sbjct: 818  LQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLE-NQ 876

Query: 643  HGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
            +   Q    ++    +  ++++E   + E + ++  +E  E R     L L     +   
Sbjct: 877  NLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSP 936

Query: 703  TVKINELKSVQNDSQAIAEVLNQLKDM--------LANFRGSEKYCYLQNEVFGLFQKLE 754
            +VK + L SV+   + I  +  + K+         L   +  ++    + E   + ++LE
Sbjct: 937  SVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELE 996

Query: 755  NINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI 814
            ++    D    S+   R L+Q     +++L  YE    + E + ++ ++   +   ++ +
Sbjct: 997  SLRSEKDQLSASM---RDLIQGAESYKNLLLEYEK---QSEQLDVEKERANNFEHRIEDL 1050

Query: 815  KNDLNLK-----------KSLLATMKT-----ELQKAQQIHSQTSQQYPLYDLDLGKFGE 858
               L              + LLA ++T     +L + Q +  Q ++     +L+  K  +
Sbjct: 1051 TRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKL-Q 1109

Query: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918
            K  ++ +    +++  + ++  L+K+ KQL+      +   K   DA+  Q +L +M+  
Sbjct: 1110 KEQKIKEHATTVNELEELQV-QLQKEKKQLQKTMQELELVKK---DAQ--QTTLMNMEIA 1163

Query: 919  DSNTVMRFLNEQ--------KNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTS 970
            D   +M+ LN++        ++L  EI  ++ K E +Q+      +S++ YE +      
Sbjct: 1164 DYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEK------ 1217

Query: 971  GLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK 1030
                  N  IK+ ++++   +   + A+               +  L   LK   +L+  
Sbjct: 1218 ------NTKIKQLLVKTKKELADSKQAETD-------------HLILQASLKG--ELEAS 1256

Query: 1031 NTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDG 1090
              ++EV + +L    +  SE    ++ L  + +++Q   S ++ ++ +L+E  R A+ + 
Sbjct: 1257 QQQVEVYKIQLA---EITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQ 1313

Query: 1091 KSAKQNLD----KCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR 1146
             +     +    + +  +K+   K +    E E  K+ R+ +E   DQ K      Q   
Sbjct: 1314 ATVTSEFESYKVRVHNVLKQQKNK-SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372

Query: 1147 QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQC 1206
            Q     L  Q L+SE      +  +ER   +LQE  +++ E   +L    +     K++ 
Sbjct: 1373 QINVSEL--QTLQSEH-----DTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEH 1425

Query: 1207 TQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQND 1264
            TQ V +  S    ++   +D+ R   L++E  +   TL+ +     ++E +  Q++N+
Sbjct: 1426 TQTVSQLTSQNEVLRNSFRDQVR--HLQEEHRKTVETLQQQL---SKMEAQLFQLKNE 1478



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 257/1431 (17%), Positives = 583/1431 (40%), Gaps = 219/1431 (15%)

Query: 49   TDQNSDGYCQTGTMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELD 108
            TD+  +   Q   +    +Q+  Q+ + +  + L++ + I Q E+K    +         
Sbjct: 209  TDEKKETVTQLQNIIEANSQH-YQKNINSLQEELLQLKAIHQEEVKE---LMCQIEASAK 264

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKG 168
            E  A+ N   E+ ++L+++       C+A +K + +  E          +  +R+A+S  
Sbjct: 265  EHEAEINKLNELKENLVKQ-------CEASEKNIQKKYE--------CELENLRKATSNA 309

Query: 169  G-GGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMD------------MVAWGVDLASVE 215
                  C      + F + V +E +  +     E++            M    + L    
Sbjct: 310  NQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDA 369

Query: 216  QHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQ-LEEEYENLLKASFERMD-HLRQLQ 273
            QHI       +   D  ++++++     E+  + + L+ E   L K     ++ H R++Q
Sbjct: 370  QHIKDE--FFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQ 427

Query: 274  NIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQES 333
            ++ +   +EI  +N+              T ++  ++     M +++  +++   L+QE 
Sbjct: 428  SLKEQHQKEISELNE--------------TFLSDSEKEKLTLMFEIQGLKEQCENLQQEK 473

Query: 334  DQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYF-QFFEEAQSTEAY- 391
             + +LN     + +   M+ LQT+              L E+A    Q FE  +  +A  
Sbjct: 474  QEAILNY----ESLREIMEILQTE--------------LGESAGKISQEFESMKQQQASD 515

Query: 392  LKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPR 451
            +  LQ  +R  +  +K+     LLE +  L+ E EK+L  +  V  L N  K    L+ +
Sbjct: 516  VHELQQKLRTAFT-EKDA----LLETVNRLQGENEKLLSQQELVPELENTIK---NLQEK 567

Query: 452  NPDY---RSNKPIILRALCDYKQDQKIVHKGDECI--LKDNNERSKWYVTGPGGVDMLVP 506
            N  Y    S +  +L+ L    +   +  + D+ I  LK+++E    +       + L+ 
Sbjct: 568  NGVYLLSLSQRDTMLKEL--EGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLIL 625

Query: 507  SVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIA 566
             +G  +        +L  K+ +    +     +   N + L      M  + + + +  A
Sbjct: 626  ELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSA 685

Query: 567  KLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQL 626
            ++K++ +E+   +    +L     +  SQ  ++   +   +++ +     +    L   L
Sbjct: 686  EVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL 745

Query: 627  PGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRM 686
                  +    T++  +G  +++  ++V E + E D     ++  LQ +   +     ++
Sbjct: 746  ENEQVQKLFVKTQL--YGFLKEMG-SEVSEDSEEKD-----VVNVLQAVGESL----AKI 793

Query: 687  TLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEV 746
              +   LA Q     + ++  E+K +Q +S    E   +LK +L ++         + E 
Sbjct: 794  NEEKCNLAFQRDEKVLELE-KEIKCLQEESVVQCE---ELKSLLRDY---------EQEK 840

Query: 747  FGLFQKLENINGVTDGYLNSLCTVR-ALLQAILQTEDMLKVYEARLTEEETVCLDLD-KV 804
              L ++LE I    +   + L  ++ A  +  L+ +++L     ++ E    C   +   
Sbjct: 841  VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL----IQVEEVSQTCSKSEIHN 896

Query: 805  EAYRCGLKKIKN--------DLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856
            E  +C +K+ +N        +L  +++ L  +K  L K+  + +      PL  +   + 
Sbjct: 897  EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKND-----PLSSVK--EL 949

Query: 857  GEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMK 916
             EK+  L    +  +++I+       K  K+L + R   Q   + L   +  +D L +  
Sbjct: 950  EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSA-- 1007

Query: 917  FGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLL 976
                  +++     KNL  E   + ++ +  ++ A    + I+D   QL + T   ET  
Sbjct: 1008 --SMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET-- 1063

Query: 977  NIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEV 1036
                           I  +  D+ AR IE L  +          ++  + +  K  + E 
Sbjct: 1064 ---------------INSDNEDLLAR-IETLQSNAKLLEVQILEVQRAKAMVDKELEAEK 1107

Query: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
            L++E ++   A + N      L++   + Q E  Q +  +  LE +K+ A+   ++   N
Sbjct: 1108 LQKEQKIKEHATTVN-----ELEELQVQLQKEKKQLQKTMQELELVKKDAQ---QTTLMN 1159

Query: 1097 LDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-RQCEKENL 1153
            ++    +  +KELN+K+T    +IED ++  K  + + +  + +   LQ + +Q E++N 
Sbjct: 1160 MEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNT 1219

Query: 1154 GWQKL--ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQ 1211
              ++L  +++K + + + + E   ++LQ         + EL  +  +++  K Q  ++  
Sbjct: 1220 KIKQLLVKTKKELADSK-QAETDHLILQ------ASLKGELEASQQQVEVYKIQLAEITS 1272

Query: 1212 ERESLLVKIK--------VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQN 1263
            E+  +   +K         L   + R+  L++E   AK+    +  V    E  K ++ N
Sbjct: 1273 EKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKA---EQATVTSEFESYKVRVHN 1329

Query: 1264 DLNQWKTQYSRKEEAIRKIESEREKSERE----------------KNSLR---SEIERLQ 1304
             L Q      +K +++ + E+E  K ERE                +N+L+   SE++ LQ
Sbjct: 1330 VLKQ------QKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQ 1383

Query: 1305 AEIKRIEERCRRKLEDST------RETQSQLETE----RSRYQREIDKLRQRPYGSHRET 1354
            +E   + ER  + L+++       RE    +++E    +S + + + +L  +        
Sbjct: 1384 SEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSF 1443

Query: 1355 QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV 1405
            + +     +  +   + L+++++ M+    QL ++ T    +  ++S++ +
Sbjct: 1444 RDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNL 1494



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 189/953 (19%), Positives = 383/953 (40%), Gaps = 160/953 (16%)

Query: 812  KKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQR-- 869
            K  ++  NL+K L   M T+L+ ++Q+  Q + +      ++ K  E++ ++   ++   
Sbjct: 144  KYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSED-----NVKKLQEEIEKIRPGFEEQI 198

Query: 870  --IDKQIDFRLWDLEKQIKQLRNYRD-NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRF 926
              + KQ+D    + ++ + QL+N  + N Q + K   +    Q+ L  +K          
Sbjct: 199  LYLQKQLDATTDEKKETVTQLQNIIEANSQHYQK---NINSLQEELLQLK-------AIH 248

Query: 927  LNEQKNLHSEISGKRDKSE-EVQKIAELCANSIKDYELQ----LASYTSGLETLLNIPIK 981
              E K L  +I     + E E+ K+ EL  N +K  E         Y   LE L      
Sbjct: 249  QEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSN 308

Query: 982  RTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLED-LKLKNTKIEVLEEE 1040
                     ++LQE   V               + ++E +K LED LK   ++  +L++E
Sbjct: 309  ANQDNQICSILLQENTFVE--------------QVVNEKVKHLEDTLKELESQHSILKDE 354

Query: 1041 ------LRLARDANSENCNKNKFLDQN----------LQKYQAEC--SQFKAKLASL-EE 1081
                  L+L  + ++++     F ++           L K +  C   + K++LA L ++
Sbjct: 355  VTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ 414

Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELN---------EKITRLTYEIEDEKRRRKSVEDRF 1132
                 E   +  +   ++   +I ELN         EK+T L +EI+  K + ++++   
Sbjct: 415  FCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLT-LMFEIQGLKEQCENLQQEK 473

Query: 1133 DQQKNDYDQLQKARQCEKENLG------WQKLESEK----------------AIKEKEYE 1170
             +   +Y+ L++  +  +  LG       Q+ ES K                A  EK+  
Sbjct: 474  QEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDAL 533

Query: 1171 IERLRVLL--QEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLV----KIKVLE 1224
            +E +  L    E+   ++E   EL      +QE        + +R+++L     KI  L 
Sbjct: 534  LETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLT 593

Query: 1225 QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ---QIQNDLNQWKTQYSRKEEAIRK 1281
            ++K      +D +N+ K++ E      ++ E E++   ++   + Q     S  E+ + +
Sbjct: 594  EEK------DDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNE 647

Query: 1282 IESEREKSEREKNSLRSEIERLQAEIKRIEE--RCRRKLEDSTRETQSQLETERSRYQRE 1339
            +    E++ +EK+    ++E+L  ++K + E          S  E  ++L +E+ +  R+
Sbjct: 648  LTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRD 707

Query: 1340 IDK-LRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKG 1398
            ++  L Q+     +E  T+ E  +       D L K +   Q+   +L  KT L   LK 
Sbjct: 708  LEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQ--KLFVKTQLYGFLKE 765

Query: 1399 KKSVEEVASEIQPFLRGAGSIAGASAS-PKEKYSLVEAKRKKLISPESTVMLLEAQAAT- 1456
              S     SE +  +    ++  + A   +EK +L   + +K++  E  +  L+ ++   
Sbjct: 766  MGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQ 825

Query: 1457 ----GGIIDPHRNEKLTV----------DSAIARDLIDFDDRQQIYAAEKAITGFDDPFS 1502
                  ++  +  EK+ +            A+  DL++  +  +    E           
Sbjct: 826  CEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEV 885

Query: 1503 GKTVSVSEAIKKN----LIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRD 1558
             +T S SE   +     + + E    LLE +     + D    + L KD +LA+    + 
Sbjct: 886  SQTCSKSEIHNEKEKCFIKEHENLKPLLEQK----ELRDRRAELILLKD-SLAKSPSVK- 939

Query: 1559 LYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPV 1618
                 NDP  S K       ++K+  ++ + + + E    + L++V+ +       ++  
Sbjct: 940  -----NDPLSSVKEL-----EEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQ 989

Query: 1619 TVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQ 1671
            TV E             ELES +   D++   ++D +QG+     +  E  KQ
Sbjct: 990  TVKE-------------ELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQ 1029



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 46/266 (17%), Positives = 121/266 (45%), Gaps = 18/266 (6%)

Query: 1163 AIKEKEYEIERLRVLLQEEGTR-KREYENELAKASNRIQESKNQCTQVVQERESLLVKIK 1221
            A+  ++ E E+  + L++E  + K+E E+ + K  +  +E +      V+E E+L  ++ 
Sbjct: 80   ALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELM 139

Query: 1222 VLE----QDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEE 1277
             +     +DKA LQ+  +E    +  L  + + +   E   +++Q ++ + +  +  +  
Sbjct: 140  AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQIL 199

Query: 1278 AIRK-----IESEREKSEREKNSLRSEIERLQAEIKRIEE---RCRRKLEDSTRETQSQL 1329
             ++K      + ++E   + +N + +  +  Q  I  ++E   + +   ++  +E   Q+
Sbjct: 200  YLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQI 259

Query: 1330 ETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAM----QLYECQ 1385
            E     ++ EI+KL +      ++ +   +      +   + LRK  +      Q+    
Sbjct: 260  EASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSIL 319

Query: 1386 LIDKTTLDKLLKGK-KSVEEVASEIQ 1410
            L + T +++++  K K +E+   E++
Sbjct: 320  LQENTFVEQVVNEKVKHLEDTLKELE 345



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 53/218 (24%), Positives = 101/218 (46%), Gaps = 10/218 (4%)

Query: 1199 IQESKNQCTQVVQERESLLVKIKVLEQD----KARLQRLEDELNRAKSTLEAETRVKQRL 1254
            IQ++K++CT++ +E E L  K  V E      KA  +RL+  L     T +    +K+  
Sbjct: 41   IQKAKSRCTELEKEIEELRSK-PVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKEN 99

Query: 1255 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEI-KRIEER 1313
               KQ++++ + +    +   E++      E E  + E  ++RS+    +A + K++EE 
Sbjct: 100  IKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEA 159

Query: 1314 CRRKLEDSTR-ETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGL 1372
               +LE S + + Q+  E    + Q EI+K+R          Q + + T D  K     L
Sbjct: 160  MNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQL 219

Query: 1373 RKKVTA-MQLYECQLIDKTTLDKLLKGKKSVEEVASEI 1409
            +  + A  Q Y+  +   +  ++LL+ K   +E   E+
Sbjct: 220  QNIIEANSQHYQKNI--NSLQEELLQLKAIHQEEVKEL 255


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  103 bits (256), Expect = 3e-21
 Identities = 155/753 (20%), Positives = 307/753 (40%), Gaps = 113/753 (15%)

Query: 653  KVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSV 712
            + ++T  E+    T    EL+  R Q       +T+    L ++  SH    ++ E++  
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEETRSHE--AQVQEMR-- 1198

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            Q  +QA+ E+  QL+         +K     N+     Q LE  N    G L      R 
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDK-----NK-----QTLEKENADLAGEL------RV 1242

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEA-YRCGLKKIKNDLNLKKSLL------ 825
            L QA  + E   K  EA++ E ++ C D ++  A     + K++N++     +L      
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302

Query: 826  --------ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR 877
                    A++ ++LQ  Q++  + ++Q       L +  E+   L D+   +D++++ +
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAK 1359

Query: 878  LWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
              +LE+ I  L     N Q     L D+K++     S          RF  E +NL  + 
Sbjct: 1360 Q-NLERHISTL-----NIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408

Query: 938  SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
              K    ++++K        + D  + L +    +  L     K   + +    I  + A
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468

Query: 998  D----VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCN 1053
            D      A   E  T++    R L E L++ E+L+  N  ++   E+L  ++D   +N +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528

Query: 1054 K----NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
            +     + L+  +++ + +  + + +L + E+ K + E++ ++ K   ++      E NE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 1110 KITRLTY--------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
            +  R           E+EDE+++R        + + D   L+              L+++
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE--------------LQAD 1634

Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENE-------LAKASNRIQESKNQCTQVVQERE 1214
             AIK +E  I++LR L  +    +RE E+         A A    +++K+    ++Q +E
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694

Query: 1215 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
             L    +  +Q     + L +EL  + S   A    K+RLE    Q++ +L + +     
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 1275 KEEAIRKI---------------------ESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
              + +RK                      ES R++ ER+   LRS++  ++  +K   + 
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
                LE    + + Q+E E    Q     L+Q+
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 139/713 (19%), Positives = 315/713 (44%), Gaps = 64/713 (8%)

Query: 743  QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
            QN      +KL  E I+ +T          + L +   + E M+   E RL +EE    +
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052

Query: 801  LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
            L+K++      +K++ D +     +A ++ ++    ++  Q +++       L +  +++
Sbjct: 1053 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1103

Query: 861  TQLTDRWQRIDKQIDFRLWDLEKQI-----------KQLRNYRDNYQAFCKWL---YDAK 906
             Q  +  ++I ++++  + DL++ +           KQ R+  +  +A    L    D+ 
Sbjct: 1104 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162

Query: 907  RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
              Q  L + +  +   + + L+E+   H E   +  + +  Q + EL    ++ ++   A
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAVEEL-TEQLEQFKRAKA 1220

Query: 967  SYTSGLETL----LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLK 1022
            +     +TL     ++  +  ++      +  +   + A+  EL ++  D  R  +E+  
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280

Query: 1023 SLEDLKLKNTKIEVLEEE-----LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
             +  L+ +   +  +  E     ++LA+D  S + ++ +   + LQ+   +      KL 
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLR 1339

Query: 1078 SLEELKR--QAELDGK-SAKQNLDKCYGQI--------KELNEKITRLTYEIEDEKRRRK 1126
             LEE +   Q +LD +  AKQNL++    +        K+L +  + +    E +KR +K
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399

Query: 1127 SVED---RFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
             +E+   +++++   YD+L+K +   Q E ++L        + +   E +  +   LL E
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459

Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1240
            E     +Y +E  +A    +E + +   + +  E  L   + LE+    L+   ++L  +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519

Query: 1241 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1300
            K  +         LE  K+ ++  + + KTQ    E+ ++  E  + + E    +L+ + 
Sbjct: 1520 KDDVGKNVH---ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576

Query: 1301 ER-LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRPYGSHRETQTEC 1358
            ER LQA  ++ EE+ RR+L+    E +++LE ER   QR +    +++  G  ++ + + 
Sbjct: 1577 ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDLKDLELQA 1633

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLID-KTTLDKLLKGKKSVEEVASEIQ 1410
            +  +   +     LRK    M+ ++ +L D + + D++    K  E+ A  ++
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 104/496 (20%), Positives = 231/496 (46%), Gaps = 65/496 (13%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  +++  E+EL+  ++   +  N+ K L+Q
Sbjct: 824  AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 880

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
               +   E +  +      E+L+ + EL            Y + +E+  ++     E+E+
Sbjct: 881  KHSQLTEEKNLLQ------EQLQAETEL------------YAEAEEMRVRLAAKKQELEE 922

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
                   +E R +++++   QLQ     E++ +  Q L+ E+ ++E+E   ++L++    
Sbjct: 923  ILHE---MEARLEEEEDRGQQLQ----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975

Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR-LQRL----ED 1235
               + ++ E+E+    ++  +   +  ++++ER S L      E++KA+ L +L    E 
Sbjct: 976  AEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
             ++  +  L+ E + +Q LE  K++++ D + +  Q +  +  I +++ +  K E E   
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE--- 1091

Query: 1296 LRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1353
            L++ + RL  EI +     +  R+LE    + Q  L++ER+   R   + ++R  G   E
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDLGEELE 1149

Query: 1354 T-QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT------TLDKLLKGKKSVEEVA 1406
              +TE E T+D++    +   K+   + + +  L ++T        +   K  ++VEE+ 
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209

Query: 1407 SEIQPFLRGAGSI-AGASASPKEKYSL-------------VEAKRKKLISPESTVMLLEA 1452
             +++ F R   ++        KE   L             VE K+KKL   E+ V  L++
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQS 1266

Query: 1453 QAATGGIIDPHRNEKL 1468
            + + G       N+K+
Sbjct: 1267 KCSDGERARAELNDKV 1282



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 176/1017 (17%), Positives = 391/1017 (38%), Gaps = 117/1017 (11%)

Query: 197  QQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYE 256
            +Q+ +++ V     +  +E  I      +N +   R  L++  +DL    A  + EE+ +
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK 1023

Query: 257  NLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRM 316
            NL K   +    + +L+  ++   +    +   + + L  D SD +  IA  Q   +   
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELK 1082

Query: 317  SQLEVKEKELNKLKQESDQLVLNQHPASDKI---EAYMDTLQTQWSWILQITKCIDVHLK 373
             QL  KE+EL       D  +  ++ A  KI   E ++  LQ                  
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD---------SERAA 1133

Query: 374  ENAAYFQFFEEAQSTEAYLKGLQDSI-----RKKYPCDKNMPLQHLLEQIKELEKEREKI 428
             N A  Q  +  +  EA    L+D++     +++    +   +  L + + E  +  E  
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 429  LEYKRQ--VQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKD 486
            ++  RQ   Q +   ++++ Q K    +   NK  + +   D   + +++ +  + +   
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250

Query: 487  NNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY---EAILALWNQLYIN 543
             +++ K        ++  V  +            +L+ K+ +     E++  + N+    
Sbjct: 1251 EHKKKK--------LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302

Query: 544  MKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDD 603
               L        D+  + +      + +++E   K     +L   E  RNS   ++  D+
Sbjct: 1303 AIKLAK------DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL--DE 1354

Query: 604  DKRKIQSQFTDAQKHYQTLVIQLPGYPQ--HQTVTTTEITHHGTCQDVNHNKVIE--TNR 659
            +    Q+     ++H  TL IQL    +      +T E    G  +     K IE  T +
Sbjct: 1355 EMEAKQN----LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR---FQKEIENLTQQ 1407

Query: 660  ENDKQETWMLMELQKIRRQ-------IEHCEGRMTLKNLPLADQGSSHHITVKIN-ELKS 711
              +K   +  +E  K R Q       ++    R  + NL    +     +  + N   K 
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467

Query: 712  VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
                 +A AE   +    L+  R  E       E     ++LE  N +    +  L + +
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALE-------EALEAKEELERTNKMLKAEMEDLVSSK 1520

Query: 772  ALL-QAILQTEDMLKVYEARLTEEETVCLDL-DKVEAYRCGLKKIKNDLN-LKKSLLATM 828
              + + + + E   +  E ++ E +T   +L D+++A      +++ ++  LK      +
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVT-------QLTDRWQRIDKQIDFRLWDL 881
            +   ++ ++   Q  +Q   Y+ +L    ++         +L    + ++ Q D  +   
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640

Query: 882  EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
            E+ IKQLR  +   + F + L DA+  +D + +    +         +   L  +++   
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA-- 1698

Query: 942  DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHA 1001
              +E  +K A+L    + +   +LAS  SG          R  +Q     +    A +  
Sbjct: 1699 --AERARKQADLEKEELAE---ELASSLSG----------RNALQDEKRRLEARIAQLEE 1743

Query: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
               EL    G+       + K+ +  +  + ++       +    A  +   +NK L   
Sbjct: 1744 ---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800

Query: 1062 LQ--------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
            L         K+++  +  +AK+A LEE   Q   + ++A ++L       K+ ++K+  
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL-------KQKDKKLKE 1853

Query: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
            +  ++EDE++  +  +++ ++      QL+  RQ E+     Q++ + +   ++E +
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLK--RQLEEAEEESQRINANRRKLQRELD 1908



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)

Query: 55   GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
            GY      ++ Q Q T  +++Q NC+  L +R     +   K    +Q+TR  E     +
Sbjct: 799  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 858

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
            +   +  ++ +  ++ ++E+ Q        +K LLQ Q Q    LY      RVR A+ K
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 917

Query: 168  GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
                   +      E    +  E     R Q+ + +       +  +E+ +         
Sbjct: 918  Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 228  IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
            +     QL+K+ A+ + K    +LE+E    +    ++ + L + + +++    ++   N
Sbjct: 969  L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1014

Query: 288  DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
              EEEE       K  N+ + +      +S+LEV+ K+  K +QE ++L    +  ASD 
Sbjct: 1015 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 347  IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
             E   D LQ Q +            LK      Q  ++ +  +A L  L D I +K    
Sbjct: 1068 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1106

Query: 407  KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
                  + L++I+ELE    + ++ L+ +R  +N   K K+
Sbjct: 1107 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  103 bits (256), Expect = 3e-21
 Identities = 155/753 (20%), Positives = 307/753 (40%), Gaps = 113/753 (15%)

Query: 653  KVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSV 712
            + ++T  E+    T    EL+  R Q       +T+    L ++  SH    ++ E++  
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEETRSHE--AQVQEMR-- 1205

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            Q  +QA+ E+  QL+         +K     N+     Q LE  N    G L      R 
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDK-----NK-----QTLEKENADLAGEL------RV 1249

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEA-YRCGLKKIKNDLNLKKSLL------ 825
            L QA  + E   K  EA++ E ++ C D ++  A     + K++N++     +L      
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309

Query: 826  --------ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR 877
                    A++ ++LQ  Q++  + ++Q       L +  E+   L D+   +D++++ +
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAK 1366

Query: 878  LWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
              +LE+ I  L     N Q     L D+K++     S          RF  E +NL  + 
Sbjct: 1367 Q-NLERHISTL-----NIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415

Query: 938  SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
              K    ++++K        + D  + L +    +  L     K   + +    I  + A
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475

Query: 998  D----VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCN 1053
            D      A   E  T++    R L E L++ E+L+  N  ++   E+L  ++D   +N +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535

Query: 1054 K----NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
            +     + L+  +++ + +  + + +L + E+ K + E++ ++ K   ++      E NE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 1110 KITRLTY--------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
            +  R           E+EDE+++R        + + D   L+              L+++
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE--------------LQAD 1641

Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENE-------LAKASNRIQESKNQCTQVVQERE 1214
             AIK +E  I++LR L  +    +RE E+         A A    +++K+    ++Q +E
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701

Query: 1215 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
             L    +  +Q     + L +EL  + S   A    K+RLE    Q++ +L + +     
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 1275 KEEAIRKI---------------------ESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
              + +RK                      ES R++ ER+   LRS++  ++  +K   + 
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
                LE    + + Q+E E    Q     L+Q+
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 139/713 (19%), Positives = 315/713 (44%), Gaps = 64/713 (8%)

Query: 743  QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
            QN      +KL  E I+ +T          + L +   + E M+   E RL +EE    +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059

Query: 801  LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
            L+K++      +K++ D +     +A ++ ++    ++  Q +++       L +  +++
Sbjct: 1060 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1110

Query: 861  TQLTDRWQRIDKQIDFRLWDLEKQI-----------KQLRNYRDNYQAFCKWL---YDAK 906
             Q  +  ++I ++++  + DL++ +           KQ R+  +  +A    L    D+ 
Sbjct: 1111 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169

Query: 907  RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
              Q  L + +  +   + + L+E+   H E   +  + +  Q + EL    ++ ++   A
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAVEEL-TEQLEQFKRAKA 1227

Query: 967  SYTSGLETL----LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLK 1022
            +     +TL     ++  +  ++      +  +   + A+  EL ++  D  R  +E+  
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287

Query: 1023 SLEDLKLKNTKIEVLEEE-----LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
             +  L+ +   +  +  E     ++LA+D  S + ++ +   + LQ+   +      KL 
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLR 1346

Query: 1078 SLEELKR--QAELDGK-SAKQNLDKCYGQI--------KELNEKITRLTYEIEDEKRRRK 1126
             LEE +   Q +LD +  AKQNL++    +        K+L +  + +    E +KR +K
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

Query: 1127 SVED---RFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
             +E+   +++++   YD+L+K +   Q E ++L        + +   E +  +   LL E
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1240
            E     +Y +E  +A    +E + +   + +  E  L   + LE+    L+   ++L  +
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526

Query: 1241 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1300
            K  +         LE  K+ ++  + + KTQ    E+ ++  E  + + E    +L+ + 
Sbjct: 1527 KDDVGKNVH---ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 1301 ER-LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRPYGSHRETQTEC 1358
            ER LQA  ++ EE+ RR+L+    E +++LE ER   QR +    +++  G  ++ + + 
Sbjct: 1584 ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDLKDLELQA 1640

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLID-KTTLDKLLKGKKSVEEVASEIQ 1410
            +  +   +     LRK    M+ ++ +L D + + D++    K  E+ A  ++
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 104/496 (20%), Positives = 231/496 (46%), Gaps = 65/496 (13%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  +++  E+EL+  ++   +  N+ K L+Q
Sbjct: 831  AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 887

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
               +   E +  +      E+L+ + EL            Y + +E+  ++     E+E+
Sbjct: 888  KHSQLTEEKNLLQ------EQLQAETEL------------YAEAEEMRVRLAAKKQELEE 929

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
                   +E R +++++   QLQ     E++ +  Q L+ E+ ++E+E   ++L++    
Sbjct: 930  ILHE---MEARLEEEEDRGQQLQ----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982

Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR-LQRL----ED 1235
               + ++ E+E+    ++  +   +  ++++ER S L      E++KA+ L +L    E 
Sbjct: 983  AEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
             ++  +  L+ E + +Q LE  K++++ D + +  Q +  +  I +++ +  K E E   
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE--- 1098

Query: 1296 LRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1353
            L++ + RL  EI +     +  R+LE    + Q  L++ER+   R   + ++R  G   E
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDLGEELE 1156

Query: 1354 T-QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT------TLDKLLKGKKSVEEVA 1406
              +TE E T+D++    +   K+   + + +  L ++T        +   K  ++VEE+ 
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216

Query: 1407 SEIQPFLRGAGSI-AGASASPKEKYSL-------------VEAKRKKLISPESTVMLLEA 1452
             +++ F R   ++        KE   L             VE K+KKL   E+ V  L++
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQS 1273

Query: 1453 QAATGGIIDPHRNEKL 1468
            + + G       N+K+
Sbjct: 1274 KCSDGERARAELNDKV 1289



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 176/1017 (17%), Positives = 391/1017 (38%), Gaps = 117/1017 (11%)

Query: 197  QQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYE 256
            +Q+ +++ V     +  +E  I      +N +   R  L++  +DL    A  + EE+ +
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK 1030

Query: 257  NLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRM 316
            NL K   +    + +L+  ++   +    +   + + L  D SD +  IA  Q   +   
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELK 1089

Query: 317  SQLEVKEKELNKLKQESDQLVLNQHPASDKI---EAYMDTLQTQWSWILQITKCIDVHLK 373
             QL  KE+EL       D  +  ++ A  KI   E ++  LQ                  
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD---------SERAA 1140

Query: 374  ENAAYFQFFEEAQSTEAYLKGLQDSI-----RKKYPCDKNMPLQHLLEQIKELEKEREKI 428
             N A  Q  +  +  EA    L+D++     +++    +   +  L + + E  +  E  
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 429  LEYKRQ--VQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKD 486
            ++  RQ   Q +   ++++ Q K    +   NK  + +   D   + +++ +  + +   
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257

Query: 487  NNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY---EAILALWNQLYIN 543
             +++ K        ++  V  +            +L+ K+ +     E++  + N+    
Sbjct: 1258 EHKKKK--------LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309

Query: 544  MKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDD 603
               L        D+  + +      + +++E   K     +L   E  RNS   ++  D+
Sbjct: 1310 AIKLAK------DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL--DE 1361

Query: 604  DKRKIQSQFTDAQKHYQTLVIQLPGYPQ--HQTVTTTEITHHGTCQDVNHNKVIE--TNR 659
            +    Q+     ++H  TL IQL    +      +T E    G  +     K IE  T +
Sbjct: 1362 EMEAKQN----LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR---FQKEIENLTQQ 1414

Query: 660  ENDKQETWMLMELQKIRRQ-------IEHCEGRMTLKNLPLADQGSSHHITVKIN-ELKS 711
              +K   +  +E  K R Q       ++    R  + NL    +     +  + N   K 
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474

Query: 712  VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
                 +A AE   +    L+  R  E       E     ++LE  N +    +  L + +
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALE-------EALEAKEELERTNKMLKAEMEDLVSSK 1527

Query: 772  ALL-QAILQTEDMLKVYEARLTEEETVCLDL-DKVEAYRCGLKKIKNDLN-LKKSLLATM 828
              + + + + E   +  E ++ E +T   +L D+++A      +++ ++  LK      +
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVT-------QLTDRWQRIDKQIDFRLWDL 881
            +   ++ ++   Q  +Q   Y+ +L    ++         +L    + ++ Q D  +   
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647

Query: 882  EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
            E+ IKQLR  +   + F + L DA+  +D + +    +         +   L  +++   
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA-- 1705

Query: 942  DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHA 1001
              +E  +K A+L    + +   +LAS  SG          R  +Q     +    A +  
Sbjct: 1706 --AERARKQADLEKEELAE---ELASSLSG----------RNALQDEKRRLEARIAQLEE 1750

Query: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
               EL    G+       + K+ +  +  + ++       +    A  +   +NK L   
Sbjct: 1751 ---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807

Query: 1062 LQ--------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
            L         K+++  +  +AK+A LEE   Q   + ++A ++L       K+ ++K+  
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL-------KQKDKKLKE 1860

Query: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
            +  ++EDE++  +  +++ ++      QL+  RQ E+     Q++ + +   ++E +
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLK--RQLEEAEEESQRINANRRKLQRELD 1915



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)

Query: 55   GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
            GY      ++ Q Q T  +++Q NC+  L +R     +   K    +Q+TR  E     +
Sbjct: 806  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 865

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
            +   +  ++ +  ++ ++E+ Q        +K LLQ Q Q    LY      RVR A+ K
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 924

Query: 168  GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
                   +      E    +  E     R Q+ + +       +  +E+ +         
Sbjct: 925  Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 228  IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
            +     QL+K+ A+ + K    +LE+E    +    ++ + L + + +++    ++   N
Sbjct: 976  L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1021

Query: 288  DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
              EEEE       K  N+ + +      +S+LEV+ K+  K +QE ++L    +  ASD 
Sbjct: 1022 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 347  IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
             E   D LQ Q +            LK      Q  ++ +  +A L  L D I +K    
Sbjct: 1075 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1113

Query: 407  KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
                  + L++I+ELE    + ++ L+ +R  +N   K K+
Sbjct: 1114 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  103 bits (256), Expect = 3e-21
 Identities = 155/753 (20%), Positives = 307/753 (40%), Gaps = 113/753 (15%)

Query: 653  KVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSV 712
            + ++T  E+    T    EL+  R Q       +T+    L ++  SH    ++ E++  
Sbjct: 1156 EALKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEETRSHE--AQVQEMR-- 1205

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            Q  +QA+ E+  QL+         +K     N+     Q LE  N    G L      R 
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDK-----NK-----QTLEKENADLAGEL------RV 1249

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEA-YRCGLKKIKNDLNLKKSLL------ 825
            L QA  + E   K  EA++ E ++ C D ++  A     + K++N++     +L      
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309

Query: 826  --------ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR 877
                    A++ ++LQ  Q++  + ++Q       L +  E+   L D+   +D++++ +
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAK 1366

Query: 878  LWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
              +LE+ I  L     N Q     L D+K++     S          RF  E +NL  + 
Sbjct: 1367 Q-NLERHISTL-----NIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415

Query: 938  SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
              K    ++++K        + D  + L +    +  L     K   + +    I  + A
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475

Query: 998  D----VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCN 1053
            D      A   E  T++    R L E L++ E+L+  N  ++   E+L  ++D   +N +
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535

Query: 1054 K----NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
            +     + L+  +++ + +  + + +L + E+ K + E++ ++ K   ++      E NE
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 1110 KITRLTY--------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
            +  R           E+EDE+++R        + + D   L+              L+++
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE--------------LQAD 1641

Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENE-------LAKASNRIQESKNQCTQVVQERE 1214
             AIK +E  I++LR L  +    +RE E+         A A    +++K+    ++Q +E
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1701

Query: 1215 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
             L    +  +Q     + L +EL  + S   A    K+RLE    Q++ +L + +     
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761

Query: 1275 KEEAIRKI---------------------ESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
              + +RK                      ES R++ ER+   LRS++  ++  +K   + 
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
                LE    + + Q+E E    Q     L+Q+
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1854



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 139/713 (19%), Positives = 315/713 (44%), Gaps = 64/713 (8%)

Query: 743  QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
            QN      +KL  E I+ +T          + L +   + E M+   E RL +EE    +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059

Query: 801  LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
            L+K++      +K++ D +     +A ++ ++    ++  Q +++       L +  +++
Sbjct: 1060 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1110

Query: 861  TQLTDRWQRIDKQIDFRLWDLEKQI-----------KQLRNYRDNYQAFCKWL---YDAK 906
             Q  +  ++I ++++  + DL++ +           KQ R+  +  +A    L    D+ 
Sbjct: 1111 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1169

Query: 907  RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
              Q  L + +  +   + + L+E+   H E   +  + +  Q + EL    ++ ++   A
Sbjct: 1170 ATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAVEEL-TEQLEQFKRAKA 1227

Query: 967  SYTSGLETL----LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLK 1022
            +     +TL     ++  +  ++      +  +   + A+  EL ++  D  R  +E+  
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287

Query: 1023 SLEDLKLKNTKIEVLEEE-----LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
             +  L+ +   +  +  E     ++LA+D  S + ++ +   + LQ+   +      KL 
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLR 1346

Query: 1078 SLEELKR--QAELDGK-SAKQNLDKCYGQI--------KELNEKITRLTYEIEDEKRRRK 1126
             LEE +   Q +LD +  AKQNL++    +        K+L +  + +    E +KR +K
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406

Query: 1127 SVED---RFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
             +E+   +++++   YD+L+K +   Q E ++L        + +   E +  +   LL E
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1240
            E     +Y +E  +A    +E + +   + +  E  L   + LE+    L+   ++L  +
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526

Query: 1241 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1300
            K  +         LE  K+ ++  + + KTQ    E+ ++  E  + + E    +L+ + 
Sbjct: 1527 KDDVGKNVH---ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583

Query: 1301 ER-LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRPYGSHRETQTEC 1358
            ER LQA  ++ EE+ RR+L+    E +++LE ER   QR +    +++  G  ++ + + 
Sbjct: 1584 ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDLKDLELQA 1640

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLID-KTTLDKLLKGKKSVEEVASEIQ 1410
            +  +   +     LRK    M+ ++ +L D + + D++    K  E+ A  ++
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 104/496 (20%), Positives = 231/496 (46%), Gaps = 65/496 (13%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  +++  E+EL+  ++   +  N+ K L+Q
Sbjct: 831  AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 887

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
               +   E +  +      E+L+ + EL            Y + +E+  ++     E+E+
Sbjct: 888  KHSQLTEEKNLLQ------EQLQAETEL------------YAEAEEMRVRLAAKKQELEE 929

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
                   +E R +++++   QLQ     E++ +  Q L+ E+ ++E+E   ++L++    
Sbjct: 930  ILHE---MEARLEEEEDRGQQLQ----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982

Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR-LQRL----ED 1235
               + ++ E+E+    ++  +   +  ++++ER S L      E++KA+ L +L    E 
Sbjct: 983  AEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
             ++  +  L+ E + +Q LE  K++++ D + +  Q +  +  I +++ +  K E E   
Sbjct: 1042 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE--- 1098

Query: 1296 LRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1353
            L++ + RL  EI +     +  R+LE    + Q  L++ER+   R   + ++R  G   E
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDLGEELE 1156

Query: 1354 T-QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT------TLDKLLKGKKSVEEVA 1406
              +TE E T+D++    +   K+   + + +  L ++T        +   K  ++VEE+ 
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216

Query: 1407 SEIQPFLRGAGSI-AGASASPKEKYSL-------------VEAKRKKLISPESTVMLLEA 1452
             +++ F R   ++        KE   L             VE K+KKL   E+ V  L++
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQS 1273

Query: 1453 QAATGGIIDPHRNEKL 1468
            + + G       N+K+
Sbjct: 1274 KCSDGERARAELNDKV 1289



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 176/1017 (17%), Positives = 391/1017 (38%), Gaps = 117/1017 (11%)

Query: 197  QQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYE 256
            +Q+ +++ V     +  +E  I      +N +   R  L++  +DL    A  + EE+ +
Sbjct: 973  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK 1030

Query: 257  NLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRM 316
            NL K   +    + +L+  ++   +    +   + + L  D SD +  IA  Q   +   
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELK 1089

Query: 317  SQLEVKEKELNKLKQESDQLVLNQHPASDKI---EAYMDTLQTQWSWILQITKCIDVHLK 373
             QL  KE+EL       D  +  ++ A  KI   E ++  LQ                  
Sbjct: 1090 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD---------SERAA 1140

Query: 374  ENAAYFQFFEEAQSTEAYLKGLQDSI-----RKKYPCDKNMPLQHLLEQIKELEKEREKI 428
             N A  Q  +  +  EA    L+D++     +++    +   +  L + + E  +  E  
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200

Query: 429  LEYKRQ--VQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKD 486
            ++  RQ   Q +   ++++ Q K    +   NK  + +   D   + +++ +  + +   
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1257

Query: 487  NNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY---EAILALWNQLYIN 543
             +++ K        ++  V  +            +L+ K+ +     E++  + N+    
Sbjct: 1258 EHKKKK--------LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309

Query: 544  MKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDD 603
               L        D+  + +      + +++E   K     +L   E  RNS   ++  D+
Sbjct: 1310 AIKLAK------DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL--DE 1361

Query: 604  DKRKIQSQFTDAQKHYQTLVIQLPGYPQ--HQTVTTTEITHHGTCQDVNHNKVIE--TNR 659
            +    Q+     ++H  TL IQL    +      +T E    G  +     K IE  T +
Sbjct: 1362 EMEAKQN----LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR---FQKEIENLTQQ 1414

Query: 660  ENDKQETWMLMELQKIRRQ-------IEHCEGRMTLKNLPLADQGSSHHITVKIN-ELKS 711
              +K   +  +E  K R Q       ++    R  + NL    +     +  + N   K 
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474

Query: 712  VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
                 +A AE   +    L+  R  E       E     ++LE  N +    +  L + +
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALE-------EALEAKEELERTNKMLKAEMEDLVSSK 1527

Query: 772  ALL-QAILQTEDMLKVYEARLTEEETVCLDL-DKVEAYRCGLKKIKNDLN-LKKSLLATM 828
              + + + + E   +  E ++ E +T   +L D+++A      +++ ++  LK      +
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVT-------QLTDRWQRIDKQIDFRLWDL 881
            +   ++ ++   Q  +Q   Y+ +L    ++         +L    + ++ Q D  +   
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647

Query: 882  EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
            E+ IKQLR  +   + F + L DA+  +D + +    +         +   L  +++   
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA-- 1705

Query: 942  DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHA 1001
              +E  +K A+L    + +   +LAS  SG          R  +Q     +    A +  
Sbjct: 1706 --AERARKQADLEKEELAE---ELASSLSG----------RNALQDEKRRLEARIAQLEE 1750

Query: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
               EL    G+       + K+ +  +  + ++       +    A  +   +NK L   
Sbjct: 1751 ---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807

Query: 1062 LQ--------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
            L         K+++  +  +AK+A LEE   Q   + ++A ++L       K+ ++K+  
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL-------KQKDKKLKE 1860

Query: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
            +  ++EDE++  +  +++ ++      QL+  RQ E+     Q++ + +   ++E +
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLK--RQLEEAEEESQRINANRRKLQRELD 1915



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)

Query: 55   GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
            GY      ++ Q Q T  +++Q NC+  L +R     +   K    +Q+TR  E     +
Sbjct: 806  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 865

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
            +   +  ++ +  ++ ++E+ Q        +K LLQ Q Q    LY      RVR A+ K
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 924

Query: 168  GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
                   +      E    +  E     R Q+ + +       +  +E+ +         
Sbjct: 925  Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 228  IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
            +     QL+K+ A+ + K    +LE+E    +    ++ + L + + +++    ++   N
Sbjct: 976  L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1021

Query: 288  DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
              EEEE       K  N+ + +      +S+LEV+ K+  K +QE ++L    +  ASD 
Sbjct: 1022 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 347  IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
             E   D LQ Q +            LK      Q  ++ +  +A L  L D I +K    
Sbjct: 1075 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1113

Query: 407  KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
                  + L++I+ELE    + ++ L+ +R  +N   K K+
Sbjct: 1114 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  103 bits (256), Expect = 3e-21
 Identities = 155/753 (20%), Positives = 307/753 (40%), Gaps = 113/753 (15%)

Query: 653  KVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSV 712
            + ++T  E+    T    EL+  R Q       +T+    L ++  SH    ++ E++  
Sbjct: 1149 EALKTELEDTLDSTATQQELRAKREQ------EVTVLKKALDEETRSHE--AQVQEMR-- 1198

Query: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772
            Q  +QA+ E+  QL+         +K     N+     Q LE  N    G L      R 
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDK-----NK-----QTLEKENADLAGEL------RV 1242

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEA-YRCGLKKIKNDLNLKKSLL------ 825
            L QA  + E   K  EA++ E ++ C D ++  A     + K++N++     +L      
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302

Query: 826  --------ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR 877
                    A++ ++LQ  Q++  + ++Q       L +  E+   L D+   +D++++ +
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAK 1359

Query: 878  LWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
              +LE+ I  L     N Q     L D+K++     S          RF  E +NL  + 
Sbjct: 1360 Q-NLERHISTL-----NIQ-----LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408

Query: 938  SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
              K    ++++K        + D  + L +    +  L     K   + +    I  + A
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468

Query: 998  D----VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCN 1053
            D      A   E  T++    R L E L++ E+L+  N  ++   E+L  ++D   +N +
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528

Query: 1054 K----NKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNE 1109
            +     + L+  +++ + +  + + +L + E+ K + E++ ++ K   ++      E NE
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 1110 KITRLTY--------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
            +  R           E+EDE+++R        + + D   L+              L+++
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE--------------LQAD 1634

Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENE-------LAKASNRIQESKNQCTQVVQERE 1214
             AIK +E  I++LR L  +    +RE E+         A A    +++K+    ++Q +E
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE 1694

Query: 1215 SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSR 1274
             L    +  +Q     + L +EL  + S   A    K+RLE    Q++ +L + +     
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754

Query: 1275 KEEAIRKI---------------------ESEREKSEREKNSLRSEIERLQAEIKRIEER 1313
              + +RK                      ES R++ ER+   LRS++  ++  +K   + 
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814

Query: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346
                LE    + + Q+E E    Q     L+Q+
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQK 1847



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 139/713 (19%), Positives = 315/713 (44%), Gaps = 64/713 (8%)

Query: 743  QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
            QN      +KL  E I+ +T          + L +   + E M+   E RL +EE    +
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052

Query: 801  LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
            L+K++      +K++ D +     +A ++ ++    ++  Q +++       L +  +++
Sbjct: 1053 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1103

Query: 861  TQLTDRWQRIDKQIDFRLWDLEKQI-----------KQLRNYRDNYQAFCKWL---YDAK 906
             Q  +  ++I ++++  + DL++ +           KQ R+  +  +A    L    D+ 
Sbjct: 1104 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST 1162

Query: 907  RRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLA 966
              Q  L + +  +   + + L+E+   H E   +  + +  Q + EL    ++ ++   A
Sbjct: 1163 ATQQELRAKREQEVTVLKKALDEETRSH-EAQVQEMRQKHAQAVEEL-TEQLEQFKRAKA 1220

Query: 967  SYTSGLETL----LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLK 1022
            +     +TL     ++  +  ++      +  +   + A+  EL ++  D  R  +E+  
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280

Query: 1023 SLEDLKLKNTKIEVLEEE-----LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
             +  L+ +   +  +  E     ++LA+D  S + ++ +   + LQ+   +      KL 
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-SQLQDTQELLQEETRQKLNVSTKLR 1339

Query: 1078 SLEELKR--QAELDGK-SAKQNLDKCYGQI--------KELNEKITRLTYEIEDEKRRRK 1126
             LEE +   Q +LD +  AKQNL++    +        K+L +  + +    E +KR +K
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399

Query: 1127 SVED---RFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
             +E+   +++++   YD+L+K +   Q E ++L        + +   E +  +   LL E
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459

Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1240
            E     +Y +E  +A    +E + +   + +  E  L   + LE+    L+   ++L  +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519

Query: 1241 KSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEI 1300
            K  +         LE  K+ ++  + + KTQ    E+ ++  E  + + E    +L+ + 
Sbjct: 1520 KDDVGKNVH---ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576

Query: 1301 ER-LQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRPYGSHRETQTEC 1358
            ER LQA  ++ EE+ RR+L+    E +++LE ER   QR +    +++  G  ++ + + 
Sbjct: 1577 ERDLQARDEQNEEK-RRQLQRQLHEYETELEDERK--QRALAAAAKKKLEGDLKDLELQA 1633

Query: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLID-KTTLDKLLKGKKSVEEVASEIQ 1410
            +  +   +     LRK    M+ ++ +L D + + D++    K  E+ A  ++
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 104/496 (20%), Positives = 231/496 (46%), Gaps = 65/496 (13%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  +++  E+EL+  ++   +  N+ K L+Q
Sbjct: 824  AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 880

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
               +   E +  +      E+L+ + EL            Y + +E+  ++     E+E+
Sbjct: 881  KHSQLTEEKNLLQ------EQLQAETEL------------YAEAEEMRVRLAAKKQELEE 922

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
                   +E R +++++   QLQ     E++ +  Q L+ E+ ++E+E   ++L++    
Sbjct: 923  ILHE---MEARLEEEEDRGQQLQ----AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975

Query: 1181 EGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKAR-LQRL----ED 1235
               + ++ E+E+    ++  +   +  ++++ER S L      E++KA+ L +L    E 
Sbjct: 976  AEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034

Query: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295
             ++  +  L+ E + +Q LE  K++++ D + +  Q +  +  I +++ +  K E E   
Sbjct: 1035 MISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE--- 1091

Query: 1296 LRSEIERLQAEIKRIEERCR--RKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1353
            L++ + RL  EI +     +  R+LE    + Q  L++ER+   R   + ++R  G   E
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERA--ARNKAEKQKRDLGEELE 1149

Query: 1354 T-QTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT------TLDKLLKGKKSVEEVA 1406
              +TE E T+D++    +   K+   + + +  L ++T        +   K  ++VEE+ 
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209

Query: 1407 SEIQPFLRGAGSI-AGASASPKEKYSL-------------VEAKRKKLISPESTVMLLEA 1452
             +++ F R   ++        KE   L             VE K+KKL   E+ V  L++
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL---EAQVQELQS 1266

Query: 1453 QAATGGIIDPHRNEKL 1468
            + + G       N+K+
Sbjct: 1267 KCSDGERARAELNDKV 1282



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 176/1017 (17%), Positives = 391/1017 (38%), Gaps = 117/1017 (11%)

Query: 197  QQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYE 256
            +Q+ +++ V     +  +E  I      +N +   R  L++  +DL    A  + EE+ +
Sbjct: 966  RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA--EEEEKAK 1023

Query: 257  NLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRM 316
            NL K   +    + +L+  ++   +    +   + + L  D SD +  IA  Q   +   
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADLQAQIAELK 1082

Query: 317  SQLEVKEKELNKLKQESDQLVLNQHPASDKI---EAYMDTLQTQWSWILQITKCIDVHLK 373
             QL  KE+EL       D  +  ++ A  KI   E ++  LQ                  
Sbjct: 1083 MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD---------SERAA 1133

Query: 374  ENAAYFQFFEEAQSTEAYLKGLQDSI-----RKKYPCDKNMPLQHLLEQIKELEKEREKI 428
             N A  Q  +  +  EA    L+D++     +++    +   +  L + + E  +  E  
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193

Query: 429  LEYKRQ--VQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKD 486
            ++  RQ   Q +   ++++ Q K    +   NK  + +   D   + +++ +  + +   
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV--- 1250

Query: 487  NNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY---EAILALWNQLYIN 543
             +++ K        ++  V  +            +L+ K+ +     E++  + N+    
Sbjct: 1251 EHKKKK--------LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302

Query: 544  MKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDD 603
               L        D+  + +      + +++E   K     +L   E  RNS   ++  D+
Sbjct: 1303 AIKLAK------DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL--DE 1354

Query: 604  DKRKIQSQFTDAQKHYQTLVIQLPGYPQ--HQTVTTTEITHHGTCQDVNHNKVIE--TNR 659
            +    Q+     ++H  TL IQL    +      +T E    G  +     K IE  T +
Sbjct: 1355 EMEAKQN----LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR---FQKEIENLTQQ 1407

Query: 660  ENDKQETWMLMELQKIRRQ-------IEHCEGRMTLKNLPLADQGSSHHITVKIN-ELKS 711
              +K   +  +E  K R Q       ++    R  + NL    +     +  + N   K 
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467

Query: 712  VQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVR 771
                 +A AE   +    L+  R  E       E     ++LE  N +    +  L + +
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALE-------EALEAKEELERTNKMLKAEMEDLVSSK 1520

Query: 772  ALL-QAILQTEDMLKVYEARLTEEETVCLDL-DKVEAYRCGLKKIKNDLN-LKKSLLATM 828
              + + + + E   +  E ++ E +T   +L D+++A      +++ ++  LK      +
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVT-------QLTDRWQRIDKQIDFRLWDL 881
            +   ++ ++   Q  +Q   Y+ +L    ++         +L    + ++ Q D  +   
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640

Query: 882  EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKR 941
            E+ IKQLR  +   + F + L DA+  +D + +    +         +   L  +++   
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA-- 1698

Query: 942  DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHA 1001
              +E  +K A+L    + +   +LAS  SG          R  +Q     +    A +  
Sbjct: 1699 --AERARKQADLEKEELAE---ELASSLSG----------RNALQDEKRRLEARIAQLEE 1743

Query: 1002 RYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQN 1061
               EL    G+       + K+ +  +  + ++       +    A  +   +NK L   
Sbjct: 1744 ---ELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800

Query: 1062 LQ--------KYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITR 1113
            L         K+++  +  +AK+A LEE   Q   + ++A ++L       K+ ++K+  
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSL-------KQKDKKLKE 1853

Query: 1114 LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYE 1170
            +  ++EDE++  +  +++ ++      QL+  RQ E+     Q++ + +   ++E +
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLK--RQLEEAEEESQRINANRRKLQRELD 1908



 Score = 35.8 bits (81), Expect = 0.49
 Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)

Query: 55   GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
            GY      ++ Q Q T  +++Q NC+  L +R     +   K    +Q+TR  E     +
Sbjct: 799  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 858

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
            +   +  ++ +  ++ ++E+ Q        +K LLQ Q Q    LY      RVR A+ K
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 917

Query: 168  GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
                   +      E    +  E     R Q+ + +       +  +E+ +         
Sbjct: 918  Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 228  IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
            +     QL+K+ A+ + K    +LE+E    +    ++ + L + + +++    ++   N
Sbjct: 969  L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1014

Query: 288  DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
              EEEE       K  N+ + +      +S+LEV+ K+  K +QE ++L    +  ASD 
Sbjct: 1015 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 347  IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
             E   D LQ Q +            LK      Q  ++ +  +A L  L D I +K    
Sbjct: 1068 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1106

Query: 407  KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
                  + L++I+ELE    + ++ L+ +R  +N   K K+
Sbjct: 1107 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  102 bits (255), Expect = 3e-21
 Identities = 188/974 (19%), Positives = 387/974 (39%), Gaps = 135/974 (13%)

Query: 520  VDLSCKIEQYYEAILAL--WNQLYINMKSLVSWHYC----MIDIEKIRAMTIAKLKTMRQ 573
            V    KI++  E IL L   N  +I  K L+          +  E+ +A  +AK++  ++
Sbjct: 974  VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQE 1033

Query: 574  EDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQ 633
                  I+DLE    E ++  + +    +  KRK+  + TD Q     L  Q+       
Sbjct: 1034 V----MISDLE----ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL 1085

Query: 634  TVTTTEITH---HGTCQDVNHNKVIETNRENDKQ----------ETWMLMELQKIRRQI- 679
                 E+      G  + ++ N  ++  RE   Q          E     + +K +R + 
Sbjct: 1086 AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145

Query: 680  EHCEGRMTLKNLPLADQGSSHHITVK----INELKSVQNDSQAIAEVLNQLKDMLANFRG 735
            E  E   T     L    +   +  K    + ELK    +     E   Q++DM      
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA--QIQDMRQRHAT 1203

Query: 736  SEKYCYLQNEVFGLFQ-KLE-NINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTE 793
            + +    Q E    F+  LE N  G+        C V+ L Q   ++E   K  +A++ E
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263

Query: 794  EETVCLDLDKVEAYRCG-LKKIKNDLNLKKSLLATM-KTELQKAQQIHSQTSQQYPLYDL 851
                  + D++         K++N+L+   +LL    K  ++ A+   S  SQ     +L
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL 1323

Query: 852  DLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS 911
               +  +K+  L+ R ++++++ +      E++ +  +N      A    L D K++ D 
Sbjct: 1324 LQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382

Query: 912  LESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSG 971
                   D  T+      +K L  +      + EE     +    +    + +L   T  
Sbjct: 1383 -------DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD 1435

Query: 972  LETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL-----------TRSGDYYRFLSEM 1020
            L+    +       Q     +L E   + ARY E             T++    R L E 
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495

Query: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNK----NKFLDQNLQKYQAECSQFKAKL 1076
            L++ E+ + +N ++    E+L  ++D   +N ++     + L+Q +++ + +  + + +L
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555

Query: 1077 ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTY--------EIEDEKRRR--- 1125
             + E+ K + E++ ++ K   ++      E NE+  RL          E+EDE+++R   
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALA 1615

Query: 1126 -----------KSVEDRFDQ-----------------QKNDYDQLQKARQCEKENLGWQK 1157
                       K +E + +                  Q  DY +  +  +  ++ +  Q 
Sbjct: 1616 VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS 1675

Query: 1158 LESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLL 1217
             ESEK +K  E EI +L+  L      +R  E E  + ++ I  S +  + ++ E+  L 
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLE 1735

Query: 1218 VKI----KVLEQDKARLQRLED--------------ELNRAKSTLEAETRVKQRLECEKQ 1259
             +I    + LE++++ ++ L D              EL   +S  +     +Q+LE + +
Sbjct: 1736 ARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNK 1795

Query: 1260 QIQNDL--------NQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRI- 1310
            +++  L        +++K   S  E  I ++E + E+  +E+ +    + R + ++K I 
Sbjct: 1796 ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIF 1855

Query: 1311 -EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ---RPYGSHRETQTECEWTVDTSK 1366
             +    R+  D  +E   +      + +R++++  +   R   S R+ Q E    +D + 
Sbjct: 1856 MQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRE----LDDAT 1911

Query: 1367 LVFDGLRKKVTAMQ 1380
               +GL ++V+ ++
Sbjct: 1912 EANEGLSREVSTLK 1925



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 142/686 (20%), Positives = 282/686 (41%), Gaps = 122/686 (17%)

Query: 876  FRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHS 935
            +R++   K + Q+    +  QA  + L   K +Q  +E             L E +  H 
Sbjct: 835  WRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGE-----------LEEMERKHQ 883

Query: 936  EISGKRD-KSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQ 994
            ++  +++  +E++Q   EL A + ++   +LA+    LE +L+    R   +     ILQ
Sbjct: 884  QLLEEKNILAEQLQAETELFAEA-EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ 942

Query: 995  EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNK 1054
                    +I+ L    D      + L+ LE +  +  KI+ +EEE+ L  D NS+   +
Sbjct: 943  NEKKKMQAHIQDLEEQLDEEEGARQKLQ-LEKVTAE-AKIKKMEEEILLLEDQNSKFIKE 1000

Query: 1055 NKFLDQNLQKYQAECSQFKAKLASLEELKRQAEL----------DGKSAKQNLDKCY--- 1101
             K ++  + +  ++ ++ + K  +L +++ + E+            +  +Q L+K     
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060

Query: 1102 -GQIKELNEKITRLTYEIEDEKRRRKSVEDRF--------DQQKNDYDQLQKARQCEKEN 1152
             G+  +L ++I  L  +I++ K +    E+          D+  +  + L+  R+ + + 
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120

Query: 1153 LGWQK-LESEKAIKEK--------EYEIERLRVLL---------QEEGTRKREYE-NELA 1193
               Q+  ESEKA + K          E+E L+  L         Q+E   KRE E  EL 
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180

Query: 1194 KASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQR 1253
            KA    +E+KN   Q+   R+     ++ L +   + +R +  L + K  LE + +    
Sbjct: 1181 KALE--EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK---E 1235

Query: 1254 LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE-- 1311
            L CE + +Q    + + +  + +  ++++ ++  + +R +  L  +  +LQ E+  +   
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295

Query: 1312 -ERCRRK----------LEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEW 1360
             E   +K          LE   ++TQ  L+ E  +      ++RQ       E +   + 
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL-----EEEKNSLQE 1350

Query: 1361 TVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIA 1420
              +  +     L K+V A+Q             +L   KK V++    I+          
Sbjct: 1351 QQEEEEEARKNLEKQVLALQ------------SQLADTKKKVDDDLGTIE---------- 1388

Query: 1421 GASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRN------EKLTVDSAI 1474
                      SL EAK+K L   E+    LE +A     ++  +N      + LTVD   
Sbjct: 1389 ----------SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438

Query: 1475 ARDLIDFDDRQ-----QIYAAEKAIT 1495
             R +    +++     Q+ A EK+I+
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSIS 1464


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 99.0 bits (245), Expect = 5e-20
 Identities = 154/743 (20%), Positives = 305/743 (41%), Gaps = 98/743 (13%)

Query: 709  LKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENING---VTDGYLN 765
            L+  + ++Q   + L  +K +L   +G +    L+ +V  L  KL+++ G     +  L 
Sbjct: 410  LERRKGEAQQSNKELQNMKRLLD--QGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLK 467

Query: 766  SLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 825
             L   R LL+ +L+ +  ++  + RL E E   L     E      +++++     +   
Sbjct: 468  DLLETRELLEEVLEGKQRVEE-QLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDT 526

Query: 826  ATMKTELQKAQQIHSQTS---QQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLE 882
              ++  +Q A Q H+      Q+       L +  E+ ++ T  WQ + ++    L   +
Sbjct: 527  EQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATK 586

Query: 883  KQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTV-------MRFLNEQKNLHS 935
            +++ QLR  ++  +       +  +R+        GD+  V       +R   E K L +
Sbjct: 587  QELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646

Query: 936  E-----ISGKRDKSEEVQKIAELCANS-----IKDYELQLASYTSGLETLLNIPIKRTMI 985
            E     ++G+    E  +++A L   +     +++  LQL      L        K  M+
Sbjct: 647  ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMV 706

Query: 986  QSPSGVIL-QEAADVHARYIELLTRSGDYYRFLSEMLKSLED--------------LKLK 1030
                  +L Q  A V     E    + ++ R +  + + L++              L+ K
Sbjct: 707  AEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDK 766

Query: 1031 NTKIEVLEEELRLARDANSENCNK-----------------------------NKFLDQN 1061
              ++E  +++L  A +A+ E                                 N+ L++ 
Sbjct: 767  LQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEE 826

Query: 1062 ------LQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114
                  L++ +AE  + K  L  +++ L ++ E  G+ +KQ L +   Q+++  EK  R 
Sbjct: 827  GKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR- 885

Query: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERL 1174
              E+ D +R+ K      ++      +LQ   Q  ++ L   + E + A  +KE   +RL
Sbjct: 886  --EVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRL 943

Query: 1175 RVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLE 1234
            + L QE   +KR  ++   +     ++     T++ +E+ ++       E    R+ R  
Sbjct: 944  QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTV-------ELLTDRVNRGR 996

Query: 1235 DELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKN 1294
            D++++ ++ L  E   +Q LEC+K  ++      KT+ +   E  +K  +   + E +  
Sbjct: 997  DQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLA-SSEGFQKPSASLSQLESQNQ 1055

Query: 1295 SLRSEIERLQAEI--KRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHR 1352
             L+   ERLQAE   K + +   RKLE   +E   Q+E ER     + D+L  R     R
Sbjct: 1056 LLQ---ERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKR 1112

Query: 1353 ETQTECEWTVDTSKLVFDGLRKK 1375
            +   E E  ++      DGLRKK
Sbjct: 1113 QVD-EAEEEIER----LDGLRKK 1130



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 138/598 (23%), Positives = 257/598 (42%), Gaps = 65/598 (10%)

Query: 770  VRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLN--LKKSLLAT 827
            V  L + +L+T++ LK  +A    +E      D+    +  + +++ D    L++  L  
Sbjct: 627  VEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQL 686

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDF---RLWDLEKQ 884
             KT LQ+ +Q   + S+   + + +    G++   +    +   ++ D    R+  LE+Q
Sbjct: 687  QKT-LQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQ 745

Query: 885  IKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKS 944
            +K+ R   D  +A    L D  +R ++                 E++ L   ++  +++ 
Sbjct: 746  LKETRGLVDGGEAVEARLRDKLQRLEA-----------------EKQQLEEALNASQEEE 788

Query: 945  EEVQKIAELCANSIKDYELQLASYTSGLETL---LNIPIKRTMIQSPSGVILQEAADVHA 1001
              +          +++ +  LA      +TL   L    K+  +       L+E   +  
Sbjct: 789  GSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLD 848

Query: 1002 RYIELLTRS-----GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN- 1055
            R ++ L +       D  + L ++   LED K K  + EV + + R A+D  SE    + 
Sbjct: 849  RTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARR-EVADAQ-RQAKDWASEAEKTSG 906

Query: 1056 ---------KFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKE 1106
                     + L Q LQ  QAE    +     L +  +  E + ++ K++ D    Q+K 
Sbjct: 907  GLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKG 966

Query: 1107 LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKE 1166
            L EK++RL  E+++EK   + + DR ++ ++  DQL+   +  +E    Q LE +K   E
Sbjct: 967  LEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLR--TELMQERSARQDLECDKISLE 1024

Query: 1167 KEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQD 1226
            ++ +  + R L   EG +K         AS    ES+N   Q++QER      ++  E++
Sbjct: 1025 RQNKDLKTR-LASSEGFQK-------PSASLSQLESQN---QLLQER------LQAEERE 1067

Query: 1227 KARLQRLEDELNRAKSTLEAETR-VKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESE 1285
            K  LQ    +L R    L  +    +Q +  +K Q+   +   K Q    EE I +++  
Sbjct: 1068 KTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGL 1127

Query: 1286 REKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKL 1343
            R+K++RE        E+LQA IK +E+   RK   S  E  S L+ E      E D +
Sbjct: 1128 RKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAE--SALKNEGLSSDEEFDSV 1183



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 89/457 (19%), Positives = 196/457 (42%), Gaps = 55/457 (12%)

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070
            G+  R + E+ + L++   K  K+E  +  L    +  +E C++   L + L++ + E  
Sbjct: 362  GELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSR---LQELLERRKGEAQ 418

Query: 1071 QFKAKLASLEELKRQA------------ELDGK--------SAKQNLDKCYGQIKELNEK 1110
            Q   +L +++ L  Q             EL  K         AK+ L K   + +EL E+
Sbjct: 419  QSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEE 478

Query: 1111 ITRLTYEIEDEKRRRK--------SVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEK 1162
            +      +E++ R R+        ++++    +  + + +++  Q + E L     ++ +
Sbjct: 479  VLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQ 538

Query: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222
                 E E +++  L++       E   E     +  Q++K       QE   L ++ + 
Sbjct: 539  DHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEE 598

Query: 1223 LEQDKA-RLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRK 1281
            +E++   +++ L+ EL +A+++   +TR  + L+ E  + Q +L + + +   +E A R 
Sbjct: 599  MEEELGEKIEVLQRELEQARAS-AGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRH 657

Query: 1282 IESEREKS---EREKNSLRSEIERLQAEIKRIEERCRRKLEDSTR-------------ET 1325
             + E EK     R +     E+E    ++++  ++ R+  E++++             + 
Sbjct: 658  RDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQR 717

Query: 1326 QSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQ 1385
            ++ +ET     Q E D+ R+R  G  ++ + E    VD  + V   LR K+  ++  + Q
Sbjct: 718  RAAVETTLRETQEENDEFRRRILGLEQQLK-ETRGLVDGGEAVEARLRDKLQRLEAEKQQ 776

Query: 1386 LIDKTTLDK-----LLKGKKSVEEVASEIQPFLRGAG 1417
            L +     +     L   K+++E    E Q  L   G
Sbjct: 777  LEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLG 813


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,655,462
Number of Sequences: 37866
Number of extensions: 3612930
Number of successful extensions: 31198
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 473
Number of HSP's successfully gapped in prelim test: 1042
Number of HSP's that attempted gapping in prelim test: 13394
Number of HSP's gapped (non-prelim): 8657
length of query: 2272
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2154
effective length of database: 13,779,330
effective search space: 29680676820
effective search space used: 29680676820
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.