Search of human proteins with 58530840

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58530840 desmoplakin isoform I [Homo sapiens]
         (2871 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58530840 desmoplakin isoform I [Homo sapiens]                     5620   0.0  
gi|58530842 desmoplakin isoform II [Homo sapiens]                    2428   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       964   0.0  
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       964   0.0  
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        964   0.0  
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        964   0.0  
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        964   0.0  
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        964   0.0  
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        964   0.0  
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        964   0.0  
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]               783   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                        609   e-173
gi|221316622 dystonin isoform 3 [Homo sapiens]                        609   e-173
gi|221316618 dystonin isoform 2 [Homo sapiens]                        609   e-173
gi|34577047 dystonin isoform 1 [Homo sapiens]                         609   e-173
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             609   e-173
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]             561   e-159
gi|33188445 microfilament and actin filament cross-linker protei...   557   e-158
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   460   e-128
gi|207452735 epiplakin 1 [Homo sapiens]                               382   e-105
gi|156104874 envoplakin [Homo sapiens]                                243   2e-63
gi|45439327 periplakin [Homo sapiens]                                 233   3e-60
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            191   1e-47
gi|148746195 trichohyalin [Homo sapiens]                              188   6e-47
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   184   1e-45
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   184   1e-45
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   184   1e-45
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   184   1e-45
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   183   2e-45
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    178   8e-44

>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 5620 bits (14578), Expect = 0.0
 Identities = 2871/2871 (100%), Positives = 2871/2871 (100%)

Query: 1    MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60
            MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG
Sbjct: 1    MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60

Query: 61   TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120
            TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI
Sbjct: 61   TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120

Query: 121  LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
            LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW
Sbjct: 121  LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 241  DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300
            DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD
Sbjct: 241  DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300

Query: 301  KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360
            KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW
Sbjct: 301  KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360

Query: 361  ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420
            ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE
Sbjct: 361  ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420

Query: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480
            LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD
Sbjct: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480

Query: 481  ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540
            ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL
Sbjct: 481  ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540

Query: 541  YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600
            YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF
Sbjct: 541  YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600

Query: 601  GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660
            GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE
Sbjct: 601  GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660

Query: 661  NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720
            NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA
Sbjct: 661  NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720

Query: 721  EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
            EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT
Sbjct: 721  EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780

Query: 781  EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840
            EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS
Sbjct: 781  EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840

Query: 841  QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900
            QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK
Sbjct: 841  QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900

Query: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960
            WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD
Sbjct: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960

Query: 961  YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
            YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM
Sbjct: 961  YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020

Query: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
            LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE
Sbjct: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080

Query: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
            ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD
Sbjct: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140

Query: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
            QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200

Query: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260
            EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI
Sbjct: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260

Query: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
            LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI
Sbjct: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320

Query: 1321 QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQL 1380
            QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQL
Sbjct: 1321 QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQL 1380

Query: 1381 TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV 1440
            TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV
Sbjct: 1381 TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV 1440

Query: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL 1500
            SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL
Sbjct: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL 1500

Query: 1501 EDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ 1560
            EDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ
Sbjct: 1501 EDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ 1560

Query: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
            NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE
Sbjct: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620

Query: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680
            QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL
Sbjct: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680

Query: 1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740
            RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE
Sbjct: 1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740

Query: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE 1800
            ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE
Sbjct: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE 1800

Query: 1801 SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI 1860
            SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI
Sbjct: 1801 SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQI 1860

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDS 1920
            QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDS
Sbjct: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDS 1920

Query: 1921 TRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL 1980
            TRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL
Sbjct: 1921 TRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL 1980

Query: 1981 YECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 2040
            YECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI
Sbjct: 1981 YECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 2040

Query: 2041 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 2100
            SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF
Sbjct: 2041 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 2100

Query: 2101 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 2160
            SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR
Sbjct: 2101 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 2160

Query: 2161 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVT 2220
            SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVT
Sbjct: 2161 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVT 2220

Query: 2221 ELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKI 2280
            ELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKI
Sbjct: 2221 ELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKI 2280

Query: 2281 GLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYN 2340
            GLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYN
Sbjct: 2281 GLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYN 2340

Query: 2341 DPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE 2400
            DPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE
Sbjct: 2341 DPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEE 2400

Query: 2401 LSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNT 2460
            LSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNT
Sbjct: 2401 LSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNT 2460

Query: 2461 LRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLV 2520
            LRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLV
Sbjct: 2461 LRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLV 2520

Query: 2521 DRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDD 2580
            DRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDD
Sbjct: 2521 DRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDD 2580

Query: 2581 VFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERG 2640
            VFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERG
Sbjct: 2581 VFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERG 2640

Query: 2641 IVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEG 2700
            IVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEG
Sbjct: 2641 IVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEG 2700

Query: 2701 VKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA 2760
            VKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA
Sbjct: 2701 VKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA 2760

Query: 2761 AQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMS 2820
            AQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMS
Sbjct: 2761 AQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMS 2820

Query: 2821 SAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2871
            SAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
Sbjct: 2821 SAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2871


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score = 2428 bits (6293), Expect = 0.0
 Identities = 1238/1376 (89%), Positives = 1272/1376 (92%), Gaps = 41/1376 (2%)

Query: 1    MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60
            MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG
Sbjct: 1    MSCNGGSHPRINTLGRMIRAESGPDLRYEVTSGGGGTSRMYYSRRGVITDQNSDGYCQTG 60

Query: 61   TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120
            TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI
Sbjct: 61   TMSRHQNQNTIQELLQNCSDCLMRAELIVQPELKYGDGIQLTRSRELDECFAQANDQMEI 120

Query: 121  LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180
            LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW
Sbjct: 121  LDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGGGGYTCQSGSGW 180

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 241  DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300
            DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD
Sbjct: 241  DLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSD 300

Query: 301  KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360
            KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW
Sbjct: 301  KNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSW 360

Query: 361  ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420
            ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE
Sbjct: 361  ILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKE 420

Query: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480
            LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD
Sbjct: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGD 480

Query: 481  ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540
            ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL
Sbjct: 481  ECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQL 540

Query: 541  YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600
            YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF
Sbjct: 541  YINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMF 600

Query: 601  GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660
            GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE
Sbjct: 601  GDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRE 660

Query: 661  NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720
            NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA
Sbjct: 661  NDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIA 720

Query: 721  EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
            EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT
Sbjct: 721  EVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780

Query: 781  EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840
            EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS
Sbjct: 781  EDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHS 840

Query: 841  QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900
            QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK
Sbjct: 841  QTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCK 900

Query: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960
            WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD
Sbjct: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKD 960

Query: 961  YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020
            YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM
Sbjct: 961  YELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020

Query: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
            LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE
Sbjct: 1021 LKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080

Query: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140
            ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD
Sbjct: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD 1140

Query: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
            QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK  N   
Sbjct: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQ 1200

Query: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSI 1260
            E     +N+    +   ++ + +I + ++D +        RL R    L+DE+ R   ++
Sbjct: 1201 ES----KNQCTQVVQERESLLVKIKVLEQDKA--------RLQR----LEDELNRAKSTL 1244

Query: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
               T  ++R E        C      +KQ ++ +L Q   Q S      ++   E  K+ 
Sbjct: 1245 EAETRVKQRLE--------C------EKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE 1290

Query: 1321 QDKN---KEIERLKAEFQ--EEAKRR------WEYENELSKVRNNYDEEIISLKNQ 1365
            ++KN    EIERL+AE +  EE  RR       E +++L   R+ Y  EI  L+ +
Sbjct: 1291 REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1346



 Score = 2132 bits (5523), Expect = 0.0
 Identities = 1147/1473 (77%), Positives = 1245/1473 (84%), Gaps = 21/1473 (1%)

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQS 1468
            +K++KN L      L  ++ ++Q+ +   S+ SQ+    +++L +  +  T+ + R+++ 
Sbjct: 811  LKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRI 870

Query: 1469 LDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKL 1528
                   + D  K+I++L+   D      K L D   R   ++      +++    +N+ 
Sbjct: 871  DKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQ 930

Query: 1529 KVQEQELTRLRIDYERVSQ-----ERTVKDQDI-----TRFQNSLKELQLQKQKVEEELN 1578
            K    E++  R   E V +       ++KD ++     T    +L  + +++  ++    
Sbjct: 931  KNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSG 990

Query: 1579 RLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638
             + + A++   +  +L        R L E    + +L  +  +  ++    E++LR  RD
Sbjct: 991  VILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVL----EEELRLARD 1046

Query: 1639 VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698
                +  + +   + L++  +E    + +L   +E  +QA L  +  ++ ++     + E
Sbjct: 1047 ANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKE 1106

Query: 1699 SKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQI 1758
               +I RL    E+  +    +E+     + +YD L++ R      +N    +L S+  I
Sbjct: 1107 LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQ--CEKENLGWQKLESEKAI 1164

Query: 1759 SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVK 1818
               +  E++ L   LQ E    R+    ++ +  +ASNRIQESKNQCTQVVQERESLLVK
Sbjct: 1165 KE-KEYEIERLRVLLQEEGTRKRE----YENELAKASNRIQESKNQCTQVVQERESLLVK 1219

Query: 1819 IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI
Sbjct: 1220 IKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1279

Query: 1879 RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1938
            RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE
Sbjct: 1280 RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1339

Query: 1939 IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1998
            IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK
Sbjct: 1340 IDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGK 1399

Query: 1999 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058
            KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI
Sbjct: 1400 KSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 1459

Query: 2059 IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR 2118
            IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR
Sbjct: 1460 IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR 1519

Query: 2119 ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK 2178
            ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK
Sbjct: 1520 ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTK 1579

Query: 2179 KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES 2238
            KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES
Sbjct: 1580 KKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELES 1639

Query: 2239 GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT 2298
            GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT
Sbjct: 1640 GQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAAT 1699

Query: 2299 GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL 2358
            GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL
Sbjct: 1700 GFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKEL 1759

Query: 2359 IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP 2418
            IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP
Sbjct: 1760 IEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDP 1819

Query: 2419 NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS 2478
            NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS
Sbjct: 1820 NTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMS 1879

Query: 2479 VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL 2538
            VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL
Sbjct: 1880 VQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGL 1939

Query: 2539 VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS 2598
            VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS
Sbjct: 1940 VDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISS 1999

Query: 2599 VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG 2658
            VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG
Sbjct: 2000 VRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTG 2059

Query: 2659 GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL 2718
            GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL
Sbjct: 2060 GIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWL 2119

Query: 2719 PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK 2778
            PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK
Sbjct: 2120 PYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPK 2179

Query: 2779 TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR 2838
            TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR
Sbjct: 2180 TKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSR 2239

Query: 2839 SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2871
            SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH
Sbjct: 2240 SGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGH 2272



 Score = 85.1 bits (209), Expect = 9e-16
 Identities = 135/622 (21%), Positives = 256/622 (41%), Gaps = 95/622 (15%)

Query: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081
            K   DL LK + +  ++ EL+ A+  +S+   +    D +L K+  + +Q   +   +++
Sbjct: 813  KIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDK 872

Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVED-RFDQQKNDYD 1140
                 ++D +    +L+K   Q++   +        + D KRR+ S+E  +F        
Sbjct: 873  -----QIDFRL--WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925

Query: 1141 QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYN 1200
             L + +    E  G          ++K  E++++  L        ++YE +LA     Y 
Sbjct: 926  FLNEQKNLHSEISGK---------RDKSEEVQKIAELCANS---IKDYELQLAS----YT 969

Query: 1201 EEMSNLRNKYETEINITKTTIKE----ISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRL 1256
              +  L N     I I +T I+     I  +  D        L R     R L + +  L
Sbjct: 970  SGLETLLN-----IPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSL 1024

Query: 1257 NDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEA 1316
             D  L+ T+     EE  L + A  SE   K + L+  L++   + S+  A         
Sbjct: 1025 EDLKLKNTKIEVLEEELRLARDA-NSENCNKNKFLDQNLQKYQAECSQFKA--------- 1074

Query: 1317 AKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT 1376
                          K    EE KR+ E + + +K   N D+    +K   E    IT+ T
Sbjct: 1075 --------------KLASLEELKRQAELDGKSAK--QNLDKCYGQIK---ELNEKITRLT 1115

Query: 1377 IHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKAT 1436
                             +I++  R  +S+ +   + KN   Q  +  +  +E++  QK  
Sbjct: 1116 Y----------------EIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLE 1159

Query: 1437 GSEVSQRKQQLEVE-LRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETN 1495
             SE + ++++ E+E LR + Q        Y+  L  A+  IQ+   +  ++ Q  +    
Sbjct: 1160 -SEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLV 1218

Query: 1496 DRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQD 1555
              K LE + ARLQR++ +L +A S+       L+ + +   RL  + +++  +       
Sbjct: 1219 KIKVLEQDKARLQRLEDELNRAKST-------LEAETRVKQRLECEKQQIQNDLNQWKTQ 1271

Query: 1556 ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNL 1615
             +R + ++++++ +++K E E N L+        + K++EE     RR L++     T  
Sbjct: 1272 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER---CRRKLEDS----TRE 1324

Query: 1616 TQ-QLEQASIVKKRSEDDLRQQ 1636
            TQ QLE      +R  D LRQ+
Sbjct: 1325 TQSQLETERSRYQREIDKLRQR 1346



 Score = 38.9 bits (89), Expect = 0.074
 Identities = 28/102 (27%), Positives = 55/102 (53%), Gaps = 11/102 (10%)

Query: 1802 KNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-ECEKQQI 1860
            K+   Q+ +E E+LL         KA  +R+ D L + ++ ++A +R    + +CE++++
Sbjct: 245  KSAIYQLEEEYENLL---------KASFERM-DHLRQLQNIIQATSREIMWINDCEEEEL 294

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERL 1902
              D +   T  ++K+EA     S+ E  E+E N L+ E ++L
Sbjct: 295  LYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQL 336



 Score = 35.0 bits (79), Expect = 1.1
 Identities = 64/362 (17%), Positives = 138/362 (38%), Gaps = 59/362 (16%)

Query: 1379 QLTMQKEEDTSGYRAQ-----IDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQ-- 1431
            QLT  +E D    +A      +D+L RE R + +     +  L Q  E +R + + I   
Sbjct: 100  QLTRSRELDECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVP 159

Query: 1432 -----QQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERL 1486
                   K  G    Q     +   + VT        + +  +D  A  +     ++  +
Sbjct: 160  RVRRASSKGGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGV-----DLASV 214

Query: 1487 KQLIDKETNDRKCLEDENARLQRVQYDLQKANSS---ATETINKLKVQEQELTRLR---- 1539
            +Q I+        + D   +L +++ DL++ ++      E  N LK   + +  LR    
Sbjct: 215  EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQN 274

Query: 1540 --------------IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTAS 1585
                           + E +  + + K+ +I + Q +      Q +  E+ELN+LK+ + 
Sbjct: 275  IIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESD 334

Query: 1586 EDSCKRKKLEEELEGMRRSLKEQAIKITNLT-----------------QQLEQASIVKKR 1628
            +    +    +++E    +L+ Q   I  +T                 ++ +      K 
Sbjct: 335  QLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKG 394

Query: 1629 SEDDLRQQ----RDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
             +D +R++    +++   HL E+ +  E+ R    E +   + L+ + + + Q   RN  
Sbjct: 395  LQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPD 454

Query: 1685 FQ 1686
            ++
Sbjct: 455  YR 456


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3640 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3699

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3700 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3759

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3760 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3819

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3820 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3878

Query: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938

Query: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998

Query: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058

Query: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118

Query: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178

Query: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4179 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4238

Query: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4239 NAGGFRSRSSSVG------SSSSYPISPAVSRT--------QLASWSDPTEETGPVAGIL 4284

Query: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4285 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4344

Query: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4345 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4404

Query: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4405 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4464

Query: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4465 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4516

Query: 2864 FSSSS 2868
            FSSSS
Sbjct: 4517 FSSSS 4521



 Score =  883 bits (2282), Expect = 0.0
 Identities = 753/2950 (25%), Positives = 1369/2950 (46%), Gaps = 355/2950 (12%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 408  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 467

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 468  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 524

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 525  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 584

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 585  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 645  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 705  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 764

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 765  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 824

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 825  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 884

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 885  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 944

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 945  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 984

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 985  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1034

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1334 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1379

Query: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1380 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1423

Query: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483

Query: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1541 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1595

Query: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1654

Query: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774

Query: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1833

Query: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893

Query: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1950

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 2003

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 2004 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 2063 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2229

Query: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2286

Query: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
            A       QL E  L  +  L +K+LK K                               
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2346

Query: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406

Query: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2407 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464

Query: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2524

Query: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2584

Query: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2642

Query: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2643 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2702

Query: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2703 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2762

Query: 2363 HGIRLLEAQIATGGIIDP--------------------------------------KESH 2384
               +LL A+ A  G  DP                                        SH
Sbjct: 2763 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2822

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            R+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2823 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2882

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 2883 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2926

Query: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 2927 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 2978

Query: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 2979 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3028

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 3029 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3088

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 3089 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3148

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 3149 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3208

Query: 2802 LLEAASVSSK 2811
            LL  +  +++
Sbjct: 3209 LLPLSEKAAR 3218



 Score =  543 bits (1399), Expect = e-154
 Identities = 487/1930 (25%), Positives = 908/1930 (47%), Gaps = 208/1930 (10%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1772

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1773 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889

Query: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009

Query: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 2010 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2053

Query: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 2054 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2087

Query: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 2088 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266

Query: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326

Query: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386

Query: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446

Query: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506

Query: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566

Query: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+   ++ 
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT- 2625

Query: 1935 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1994
                +   R    G   E + E           FDGLR+KV+A +L E  ++    L +L
Sbjct: 2626 ----LPNGRDALDGPAAEAEPEHS---------FDGLRRKVSAQRLQEAGILSAEELQRL 2672

Query: 1995 LKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEA 2051
             +G  +V+E+A   +++ +L+G  SIAG    +  EK S+  A +++L+SP + ++LLEA
Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEA 2732

Query: 2052 QAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAI 2111
            QAA+G ++DP RN +LTV+ A+   ++  +   ++ +AE+A+TG+ DP++G+ +S+ +A+
Sbjct: 2733 QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAM 2792

Query: 2112 KKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKN 2171
            +K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D ++ R L DP D  K 
Sbjct: 2793 QKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKG 2852

Query: 2172 FVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV---------------------QKRSMS- 2209
            F DP T + ++Y+QL ERC  +P TGL LL +                     +K ++S 
Sbjct: 2853 FFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSA 2912

Query: 2210 ----FQGIRQPVTVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
                FQG  + VT+ E+++S       R   + +  +G+I+ +++ + I         I 
Sbjct: 2913 PFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII---------IT 2961

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
             +  +  K +L  +E ++  LV    A ELLE++     ++D     +L   E   R + 
Sbjct: 2962 VVEEQEQKGRL-CFEGLR-SLV---PAAELLESR-----VIDRELYQQLQRGERSVRDVA 3011

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
             ++   + L     + G    E G  +S++ A+ K+L+     + LLEAQ  TG IIDP 
Sbjct: 3012 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPA 3071

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
             S RL VD A + G    E  E L        G+ DP T ++++  Q  ++ +   E GL
Sbjct: 3072 TSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGL 3131

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVI----VDPETNKEMSVQEAYKKGLIDYET----- 2492
             LL  +     +    K+      V      +D ET++ +S   A  K   D  T     
Sbjct: 3132 RLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPAT 3191

Query: 2493 FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSL 2552
            + EL +Q C  +++T     G + + L ++   ++   Q+ +   L  R+ F++      
Sbjct: 3192 YGEL-QQRCRPDQLT-----GLSLLPLSEKAARAR---QEELYSELQARETFEKTPVE-- 3240

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT 2612
                    + +    G + ++   +S + F++ + + +        +R       +    
Sbjct: 3241 --------VPVGGFKGRTVTVWELISSEYFTAEQRQEL--------LRQFRTGKVTVEKV 3284

Query: 2613 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2672
            ++    I    +T   E++S +     G+   +    LL +   +          K +++
Sbjct: 3285 IKILITIVEEVETLRQERLSFS-----GLRAPVPASELLASGVLSRAQFEQLKDGKTTVK 3339

Query: 2673 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732
            D    G +       L        G      K+K+S  EA++   L        LE Q  
Sbjct: 3340 DLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAA 3394

Query: 2733 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2792
            TG LVDP  + R+   EA++ G +     ++L            P +   IS   A+ + 
Sbjct: 3395 TGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG 3454

Query: 2793 MVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSF 2850
            +V    G+RLLE A +++ G+  P +    P   +  R              S   +G F
Sbjct: 3455 LVLRQHGIRLLE-AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3513

Query: 2851 DATGNSSYSY 2860
            D   + + +Y
Sbjct: 3514 DPNTHENLTY 3523



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2936 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2991

Query: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2992 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3048

Query: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3049 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3108

Query: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3109 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3168

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3169 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3212

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3213 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3269

Query: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3270 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3329

Query: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3330 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3389

Query: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3390 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3449

Query: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3450 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3509

Query: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3510 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3569

Query: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3570 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3621

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3622 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3652

Query: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3653 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3705

Query: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3706 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3765

Query: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3766 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3825

Query: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3826 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3884

Query: 2810 SKGLPSPYNM 2819
             +GL     M
Sbjct: 3885 FRGLRKQITM 3894



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938

Query: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998

Query: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058

Query: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118

Query: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178

Query: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4179 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4234

Query: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4235 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4291

Query: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4292 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4351

Query: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4352 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4396

Query: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4397 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4443

Query: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4444 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4503

Query: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
             S        S  ++T  SSS+S +
Sbjct: 4504 GS---FDATGSGFSMTFSSSSYSSS 4525


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3644 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3703

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3704 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3763

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3764 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3823

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3824 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3882

Query: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3883 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3942

Query: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3943 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4002

Query: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4003 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4062

Query: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4063 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4122

Query: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4123 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4182

Query: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4183 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4242

Query: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4243 NAGGFRSRSSSVG------SSSSYPISPAVSRT--------QLASWSDPTEETGPVAGIL 4288

Query: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4289 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4348

Query: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4349 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4408

Query: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4409 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4468

Query: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4469 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4520

Query: 2864 FSSSS 2868
            FSSSS
Sbjct: 4521 FSSSS 4525



 Score =  883 bits (2282), Expect = 0.0
 Identities = 753/2950 (25%), Positives = 1369/2950 (46%), Gaps = 355/2950 (12%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 412  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 471

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 472  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 528

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 529  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 588

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 589  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 648

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 649  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 708

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 709  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 768

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 769  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 828

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 829  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 888

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 889  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 948

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 949  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 988

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 989  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1038

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1039 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1098

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1158

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1159 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1218

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1219 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1278

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1279 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1338 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1383

Query: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1384 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1427

Query: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1428 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1487

Query: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1545 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1599

Query: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1658

Query: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778

Query: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1837

Query: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1897

Query: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 1898 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1954

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 2007

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 2008 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2066

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 2067 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2174

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 2175 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2233

Query: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2290

Query: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
            A       QL E  L  +  L +K+LK K                               
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2350

Query: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 2351 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2410

Query: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2411 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468

Query: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2528

Query: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2529 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2588

Query: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2589 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2646

Query: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2647 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2706

Query: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2707 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2766

Query: 2363 HGIRLLEAQIATGGIIDP--------------------------------------KESH 2384
               +LL A+ A  G  DP                                        SH
Sbjct: 2767 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2826

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            R+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2827 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2886

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 2887 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2930

Query: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 2931 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 2982

Query: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 2983 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3032

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 3033 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3092

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 3093 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3152

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 3153 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3212

Query: 2802 LLEAASVSSK 2811
            LL  +  +++
Sbjct: 3213 LLPLSEKAAR 3222



 Score =  543 bits (1399), Expect = e-154
 Identities = 487/1930 (25%), Positives = 908/1930 (47%), Gaps = 208/1930 (10%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1776

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1777 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1833

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893

Query: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013

Query: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 2014 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2057

Query: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 2058 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2091

Query: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 2092 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150

Query: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270

Query: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2330

Query: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 2331 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2390

Query: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 2391 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2450

Query: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 2451 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2510

Query: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570

Query: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+   ++ 
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT- 2629

Query: 1935 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1994
                +   R    G   E + E           FDGLR+KV+A +L E  ++    L +L
Sbjct: 2630 ----LPNGRDALDGPAAEAEPEHS---------FDGLRRKVSAQRLQEAGILSAEELQRL 2676

Query: 1995 LKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEA 2051
             +G  +V+E+A   +++ +L+G  SIAG    +  EK S+  A +++L+SP + ++LLEA
Sbjct: 2677 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEA 2736

Query: 2052 QAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAI 2111
            QAA+G ++DP RN +LTV+ A+   ++  +   ++ +AE+A+TG+ DP++G+ +S+ +A+
Sbjct: 2737 QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAM 2796

Query: 2112 KKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKN 2171
            +K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D ++ R L DP D  K 
Sbjct: 2797 QKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKG 2856

Query: 2172 FVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV---------------------QKRSMS- 2209
            F DP T + ++Y+QL ERC  +P TGL LL +                     +K ++S 
Sbjct: 2857 FFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSA 2916

Query: 2210 ----FQGIRQPVTVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
                FQG  + VT+ E+++S       R   + +  +G+I+ +++ + I         I 
Sbjct: 2917 PFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII---------IT 2965

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
             +  +  K +L  +E ++  LV    A ELLE++     ++D     +L   E   R + 
Sbjct: 2966 VVEEQEQKGRL-CFEGLR-SLV---PAAELLESR-----VIDRELYQQLQRGERSVRDVA 3015

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
             ++   + L     + G    E G  +S++ A+ K+L+     + LLEAQ  TG IIDP 
Sbjct: 3016 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPA 3075

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
             S RL VD A + G    E  E L        G+ DP T ++++  Q  ++ +   E GL
Sbjct: 3076 TSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGL 3135

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVI----VDPETNKEMSVQEAYKKGLIDYET----- 2492
             LL  +     +    K+      V      +D ET++ +S   A  K   D  T     
Sbjct: 3136 RLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPAT 3195

Query: 2493 FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSL 2552
            + EL +Q C  +++T     G + + L ++   ++   Q+ +   L  R+ F++      
Sbjct: 3196 YGEL-QQRCRPDQLT-----GLSLLPLSEKAARAR---QEELYSELQARETFEKTPVE-- 3244

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT 2612
                    + +    G + ++   +S + F++ + + +        +R       +    
Sbjct: 3245 --------VPVGGFKGRTVTVWELISSEYFTAEQRQEL--------LRQFRTGKVTVEKV 3288

Query: 2613 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2672
            ++    I    +T   E++S +     G+   +    LL +   +          K +++
Sbjct: 3289 IKILITIVEEVETLRQERLSFS-----GLRAPVPASELLASGVLSRAQFEQLKDGKTTVK 3343

Query: 2673 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732
            D    G +       L        G      K+K+S  EA++   L        LE Q  
Sbjct: 3344 DLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAA 3398

Query: 2733 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2792
            TG LVDP  + R+   EA++ G +     ++L            P +   IS   A+ + 
Sbjct: 3399 TGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG 3458

Query: 2793 MVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSF 2850
            +V    G+RLLE A +++ G+  P +    P   +  R              S   +G F
Sbjct: 3459 LVLRQHGIRLLE-AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3517

Query: 2851 DATGNSSYSY 2860
            D   + + +Y
Sbjct: 3518 DPNTHENLTY 3527



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2940 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2995

Query: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2996 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3052

Query: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3053 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3112

Query: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3113 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3172

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3173 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3216

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3217 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3273

Query: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3274 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3333

Query: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3334 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3393

Query: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3394 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3453

Query: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3454 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3513

Query: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3514 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3573

Query: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3574 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3625

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3626 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3656

Query: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3657 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3709

Query: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3710 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3769

Query: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3770 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3829

Query: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3830 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3888

Query: 2810 SKGLPSPYNM 2819
             +GL     M
Sbjct: 3889 FRGLRKQITM 3898



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3883 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3942

Query: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3943 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4002

Query: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 4003 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4062

Query: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4063 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4122

Query: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4123 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4182

Query: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4183 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4238

Query: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4239 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4295

Query: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4296 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4355

Query: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4356 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4400

Query: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4401 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4447

Query: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4448 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4507

Query: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
             S        S  ++T  SSS+S +
Sbjct: 4508 GS---FDATGSGFSMTFSSSSYSSS 4529


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3640 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3699

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3700 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3759

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3760 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3819

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3820 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3878

Query: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938

Query: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998

Query: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058

Query: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118

Query: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178

Query: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4179 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4238

Query: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4239 NAGGFRSRSSSVG------SSSSYPISPAVSRT--------QLASWSDPTEETGPVAGIL 4284

Query: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4285 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4344

Query: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4345 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4404

Query: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4405 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4464

Query: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4465 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4516

Query: 2864 FSSSS 2868
            FSSSS
Sbjct: 4517 FSSSS 4521



 Score =  883 bits (2282), Expect = 0.0
 Identities = 753/2950 (25%), Positives = 1369/2950 (46%), Gaps = 355/2950 (12%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 408  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 467

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 468  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 524

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 525  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 584

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 585  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 644

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 645  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 704

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 705  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 764

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 765  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 824

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 825  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 884

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 885  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 944

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 945  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 984

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 985  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1034

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1154

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1155 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1214

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1215 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1274

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1275 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1334 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1379

Query: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1380 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1423

Query: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1424 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483

Query: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1541 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1595

Query: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1654

Query: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774

Query: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1833

Query: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893

Query: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1950

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 2003

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 2004 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2062

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 2063 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 2171 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2229

Query: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2286

Query: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
            A       QL E  L  +  L +K+LK K                               
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2346

Query: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406

Query: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2407 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464

Query: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2524

Query: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2584

Query: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2642

Query: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2643 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2702

Query: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2703 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2762

Query: 2363 HGIRLLEAQIATGGIIDP--------------------------------------KESH 2384
               +LL A+ A  G  DP                                        SH
Sbjct: 2763 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2822

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            R+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2823 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2882

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 2883 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2926

Query: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 2927 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 2978

Query: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 2979 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3028

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 3029 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3088

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 3089 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3148

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 3149 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3208

Query: 2802 LLEAASVSSK 2811
            LL  +  +++
Sbjct: 3209 LLPLSEKAAR 3218



 Score =  543 bits (1399), Expect = e-154
 Identities = 487/1930 (25%), Positives = 908/1930 (47%), Gaps = 208/1930 (10%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1772

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1773 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1829

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889

Query: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009

Query: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 2010 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2053

Query: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 2054 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2087

Query: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 2088 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266

Query: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2326

Query: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2386

Query: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446

Query: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506

Query: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566

Query: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+   ++ 
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT- 2625

Query: 1935 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1994
                +   R    G   E + E           FDGLR+KV+A +L E  ++    L +L
Sbjct: 2626 ----LPNGRDALDGPAAEAEPEHS---------FDGLRRKVSAQRLQEAGILSAEELQRL 2672

Query: 1995 LKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEA 2051
             +G  +V+E+A   +++ +L+G  SIAG    +  EK S+  A +++L+SP + ++LLEA
Sbjct: 2673 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEA 2732

Query: 2052 QAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAI 2111
            QAA+G ++DP RN +LTV+ A+   ++  +   ++ +AE+A+TG+ DP++G+ +S+ +A+
Sbjct: 2733 QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAM 2792

Query: 2112 KKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKN 2171
            +K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D ++ R L DP D  K 
Sbjct: 2793 QKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKG 2852

Query: 2172 FVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV---------------------QKRSMS- 2209
            F DP T + ++Y+QL ERC  +P TGL LL +                     +K ++S 
Sbjct: 2853 FFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSA 2912

Query: 2210 ----FQGIRQPVTVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
                FQG  + VT+ E+++S       R   + +  +G+I+ +++ + I         I 
Sbjct: 2913 PFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII---------IT 2961

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
             +  +  K +L  +E ++  LV    A ELLE++     ++D     +L   E   R + 
Sbjct: 2962 VVEEQEQKGRL-CFEGLR-SLV---PAAELLESR-----VIDRELYQQLQRGERSVRDVA 3011

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
             ++   + L     + G    E G  +S++ A+ K+L+     + LLEAQ  TG IIDP 
Sbjct: 3012 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPA 3071

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
             S RL VD A + G    E  E L        G+ DP T ++++  Q  ++ +   E GL
Sbjct: 3072 TSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGL 3131

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVI----VDPETNKEMSVQEAYKKGLIDYET----- 2492
             LL  +     +    K+      V      +D ET++ +S   A  K   D  T     
Sbjct: 3132 RLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPAT 3191

Query: 2493 FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSL 2552
            + EL +Q C  +++T     G + + L ++   ++   Q+ +   L  R+ F++      
Sbjct: 3192 YGEL-QQRCRPDQLT-----GLSLLPLSEKAARAR---QEELYSELQARETFEKTPVE-- 3240

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT 2612
                    + +    G + ++   +S + F++ + + +        +R       +    
Sbjct: 3241 --------VPVGGFKGRTVTVWELISSEYFTAEQRQEL--------LRQFRTGKVTVEKV 3284

Query: 2613 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2672
            ++    I    +T   E++S +     G+   +    LL +   +          K +++
Sbjct: 3285 IKILITIVEEVETLRQERLSFS-----GLRAPVPASELLASGVLSRAQFEQLKDGKTTVK 3339

Query: 2673 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732
            D    G +       L        G      K+K+S  EA++   L        LE Q  
Sbjct: 3340 DLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAA 3394

Query: 2733 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2792
            TG LVDP  + R+   EA++ G +     ++L            P +   IS   A+ + 
Sbjct: 3395 TGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG 3454

Query: 2793 MVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSF 2850
            +V    G+RLLE A +++ G+  P +    P   +  R              S   +G F
Sbjct: 3455 LVLRQHGIRLLE-AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3513

Query: 2851 DATGNSSYSY 2860
            D   + + +Y
Sbjct: 3514 DPNTHENLTY 3523



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2936 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2991

Query: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2992 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3048

Query: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3049 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3108

Query: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3109 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3168

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3169 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3212

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3213 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3269

Query: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3270 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3329

Query: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3330 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3389

Query: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3390 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3449

Query: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3450 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3509

Query: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3510 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3569

Query: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3570 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3621

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3622 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3652

Query: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3653 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3705

Query: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3706 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3765

Query: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3766 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3825

Query: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3826 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3884

Query: 2810 SKGLPSPYNM 2819
             +GL     M
Sbjct: 3885 FRGLRKQITM 3894



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3879 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3938

Query: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3939 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3998

Query: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3999 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4058

Query: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4059 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4118

Query: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4119 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4178

Query: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4179 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4234

Query: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4235 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4291

Query: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4292 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4351

Query: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4352 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4396

Query: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4397 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4443

Query: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4444 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4503

Query: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
             S        S  ++T  SSS+S +
Sbjct: 4504 GS---FDATGSGFSMTFSSSSYSSS 4525


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3608 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3667

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3668 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3727

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3728 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3787

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3788 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3846

Query: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3847 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3906

Query: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3907 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3966

Query: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3967 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4026

Query: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4027 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4086

Query: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4087 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4146

Query: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4147 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4206

Query: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4207 NAGGFRSRSSSVG------SSSSYPISPAVSRT--------QLASWSDPTEETGPVAGIL 4252

Query: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4253 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4312

Query: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4313 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4372

Query: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4373 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4432

Query: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4433 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4484

Query: 2864 FSSSS 2868
            FSSSS
Sbjct: 4485 FSSSS 4489



 Score =  883 bits (2282), Expect = 0.0
 Identities = 753/2950 (25%), Positives = 1369/2950 (46%), Gaps = 355/2950 (12%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 376  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 435

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 436  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 492

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 493  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 552

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 553  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 612

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 613  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 672

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 673  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 732

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 733  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 792

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 793  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 852

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 853  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 912

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 913  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 952

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 953  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1002

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1003 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1062

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1122

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1123 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1182

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1183 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1242

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1243 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1302 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1347

Query: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1348 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1391

Query: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1392 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1451

Query: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1509 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1563

Query: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1622

Query: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1742

Query: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1801

Query: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1802 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1861

Query: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 1862 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1918

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 1919 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 1971

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 1972 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2030

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 2031 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 2079 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2138

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 2139 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2197

Query: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2254

Query: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
            A       QL E  L  +  L +K+LK K                               
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2314

Query: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 2315 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2374

Query: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2375 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432

Query: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2433 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2492

Query: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2493 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2552

Query: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2553 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2610

Query: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2611 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2670

Query: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2671 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2730

Query: 2363 HGIRLLEAQIATGGIIDP--------------------------------------KESH 2384
               +LL A+ A  G  DP                                        SH
Sbjct: 2731 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2790

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            R+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2791 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2850

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 2851 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2894

Query: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 2895 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 2946

Query: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 2947 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 2996

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 2997 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3056

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 3057 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3116

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 3117 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3176

Query: 2802 LLEAASVSSK 2811
            LL  +  +++
Sbjct: 3177 LLPLSEKAAR 3186



 Score =  543 bits (1399), Expect = e-154
 Identities = 487/1930 (25%), Positives = 908/1930 (47%), Gaps = 208/1930 (10%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1740

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1741 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1797

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857

Query: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977

Query: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 1978 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2021

Query: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 2022 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2055

Query: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 2056 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114

Query: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234

Query: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2294

Query: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 2295 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2354

Query: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 2355 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2414

Query: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 2415 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2474

Query: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534

Query: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+   ++ 
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT- 2593

Query: 1935 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1994
                +   R    G   E + E           FDGLR+KV+A +L E  ++    L +L
Sbjct: 2594 ----LPNGRDALDGPAAEAEPEHS---------FDGLRRKVSAQRLQEAGILSAEELQRL 2640

Query: 1995 LKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEA 2051
             +G  +V+E+A   +++ +L+G  SIAG    +  EK S+  A +++L+SP + ++LLEA
Sbjct: 2641 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEA 2700

Query: 2052 QAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAI 2111
            QAA+G ++DP RN +LTV+ A+   ++  +   ++ +AE+A+TG+ DP++G+ +S+ +A+
Sbjct: 2701 QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAM 2760

Query: 2112 KKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKN 2171
            +K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D ++ R L DP D  K 
Sbjct: 2761 QKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKG 2820

Query: 2172 FVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV---------------------QKRSMS- 2209
            F DP T + ++Y+QL ERC  +P TGL LL +                     +K ++S 
Sbjct: 2821 FFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSA 2880

Query: 2210 ----FQGIRQPVTVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
                FQG  + VT+ E+++S       R   + +  +G+I+ +++ + I         I 
Sbjct: 2881 PFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII---------IT 2929

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
             +  +  K +L  +E ++  LV    A ELLE++     ++D     +L   E   R + 
Sbjct: 2930 VVEEQEQKGRL-CFEGLR-SLV---PAAELLESR-----VIDRELYQQLQRGERSVRDVA 2979

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
             ++   + L     + G    E G  +S++ A+ K+L+     + LLEAQ  TG IIDP 
Sbjct: 2980 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPA 3039

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
             S RL VD A + G    E  E L        G+ DP T ++++  Q  ++ +   E GL
Sbjct: 3040 TSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGL 3099

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVI----VDPETNKEMSVQEAYKKGLIDYET----- 2492
             LL  +     +    K+      V      +D ET++ +S   A  K   D  T     
Sbjct: 3100 RLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPAT 3159

Query: 2493 FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSL 2552
            + EL +Q C  +++T     G + + L ++   ++   Q+ +   L  R+ F++      
Sbjct: 3160 YGEL-QQRCRPDQLT-----GLSLLPLSEKAARAR---QEELYSELQARETFEKTPVE-- 3208

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT 2612
                    + +    G + ++   +S + F++ + + +        +R       +    
Sbjct: 3209 --------VPVGGFKGRTVTVWELISSEYFTAEQRQEL--------LRQFRTGKVTVEKV 3252

Query: 2613 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2672
            ++    I    +T   E++S +     G+   +    LL +   +          K +++
Sbjct: 3253 IKILITIVEEVETLRQERLSFS-----GLRAPVPASELLASGVLSRAQFEQLKDGKTTVK 3307

Query: 2673 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732
            D    G +       L        G      K+K+S  EA++   L        LE Q  
Sbjct: 3308 DLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAA 3362

Query: 2733 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2792
            TG LVDP  + R+   EA++ G +     ++L            P +   IS   A+ + 
Sbjct: 3363 TGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG 3422

Query: 2793 MVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSF 2850
            +V    G+RLLE A +++ G+  P +    P   +  R              S   +G F
Sbjct: 3423 LVLRQHGIRLLE-AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3481

Query: 2851 DATGNSSYSY 2860
            D   + + +Y
Sbjct: 3482 DPNTHENLTY 3491



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2904 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2959

Query: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2960 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3016

Query: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3017 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3076

Query: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3077 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3136

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3137 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3180

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3181 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3237

Query: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3238 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3297

Query: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3298 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3357

Query: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3358 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3417

Query: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3418 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3477

Query: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3478 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3537

Query: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3538 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3589

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3590 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3620

Query: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3621 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3673

Query: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3674 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3733

Query: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3734 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3793

Query: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3794 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3852

Query: 2810 SKGLPSPYNM 2819
             +GL     M
Sbjct: 3853 FRGLRKQITM 3862



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3847 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3906

Query: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3907 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3966

Query: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3967 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4026

Query: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4027 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4086

Query: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4087 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4146

Query: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4147 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4202

Query: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4203 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4259

Query: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4260 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4319

Query: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4320 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4364

Query: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4365 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4411

Query: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4412 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4471

Query: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
             S        S  ++T  SSS+S +
Sbjct: 4472 GS---FDATGSGFSMTFSSSSYSSS 4493


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3777 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3836

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3837 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3896

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3897 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3956

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3957 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 4015

Query: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075

Query: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135

Query: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195

Query: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255

Query: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315

Query: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4316 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4375

Query: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4376 NAGGFRSRSSSVG------SSSSYPISPAVSRT--------QLASWSDPTEETGPVAGIL 4421

Query: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4422 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4481

Query: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4482 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4541

Query: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4542 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4601

Query: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4602 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4653

Query: 2864 FSSSS 2868
            FSSSS
Sbjct: 4654 FSSSS 4658



 Score =  883 bits (2282), Expect = 0.0
 Identities = 753/2950 (25%), Positives = 1369/2950 (46%), Gaps = 355/2950 (12%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 545  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 604

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 605  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 661

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 662  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 721

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 722  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 781

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 782  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 841

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 842  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 901

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 902  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 961

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 962  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 1021

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 1022 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1081

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 1082 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1121

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 1122 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1171

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1351

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1352 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1411

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1412 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1471 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1516

Query: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1517 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1560

Query: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620

Query: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1678 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1732

Query: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1791

Query: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911

Query: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1970

Query: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 2030

Query: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 2031 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 2087

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 2140

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 2141 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 2200 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 2248 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2307

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 2308 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2366

Query: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2423

Query: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
            A       QL E  L  +  L +K+LK K                               
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2483

Query: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2543

Query: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2544 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601

Query: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661

Query: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2662 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2721

Query: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2722 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2779

Query: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2780 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2839

Query: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2840 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2899

Query: 2363 HGIRLLEAQIATGGIIDP--------------------------------------KESH 2384
               +LL A+ A  G  DP                                        SH
Sbjct: 2900 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2959

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            R+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2960 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 3019

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 3020 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 3063

Query: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 3064 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 3115

Query: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 3116 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3165

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 3166 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3225

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 3226 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3285

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 3286 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3345

Query: 2802 LLEAASVSSK 2811
            LL  +  +++
Sbjct: 3346 LLPLSEKAAR 3355



 Score =  543 bits (1399), Expect = e-154
 Identities = 487/1930 (25%), Positives = 908/1930 (47%), Gaps = 208/1930 (10%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1909

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1910 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1966

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026

Query: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146

Query: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 2147 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2190

Query: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 2191 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2224

Query: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 2225 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283

Query: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403

Query: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463

Query: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 2464 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523

Query: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 2524 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2583

Query: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 2584 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2643

Query: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703

Query: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+   ++ 
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT- 2762

Query: 1935 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1994
                +   R    G   E + E           FDGLR+KV+A +L E  ++    L +L
Sbjct: 2763 ----LPNGRDALDGPAAEAEPEHS---------FDGLRRKVSAQRLQEAGILSAEELQRL 2809

Query: 1995 LKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEA 2051
             +G  +V+E+A   +++ +L+G  SIAG    +  EK S+  A +++L+SP + ++LLEA
Sbjct: 2810 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEA 2869

Query: 2052 QAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAI 2111
            QAA+G ++DP RN +LTV+ A+   ++  +   ++ +AE+A+TG+ DP++G+ +S+ +A+
Sbjct: 2870 QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAM 2929

Query: 2112 KKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKN 2171
            +K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D ++ R L DP D  K 
Sbjct: 2930 QKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKG 2989

Query: 2172 FVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV---------------------QKRSMS- 2209
            F DP T + ++Y+QL ERC  +P TGL LL +                     +K ++S 
Sbjct: 2990 FFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSA 3049

Query: 2210 ----FQGIRQPVTVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
                FQG  + VT+ E+++S       R   + +  +G+I+ +++ + I         I 
Sbjct: 3050 PFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII---------IT 3098

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
             +  +  K +L  +E ++  LV    A ELLE++     ++D     +L   E   R + 
Sbjct: 3099 VVEEQEQKGRL-CFEGLR-SLV---PAAELLESR-----VIDRELYQQLQRGERSVRDVA 3148

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
             ++   + L     + G    E G  +S++ A+ K+L+     + LLEAQ  TG IIDP 
Sbjct: 3149 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPA 3208

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
             S RL VD A + G    E  E L        G+ DP T ++++  Q  ++ +   E GL
Sbjct: 3209 TSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGL 3268

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVI----VDPETNKEMSVQEAYKKGLIDYET----- 2492
             LL  +     +    K+      V      +D ET++ +S   A  K   D  T     
Sbjct: 3269 RLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPAT 3328

Query: 2493 FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSL 2552
            + EL +Q C  +++T     G + + L ++   ++   Q+ +   L  R+ F++      
Sbjct: 3329 YGEL-QQRCRPDQLT-----GLSLLPLSEKAARAR---QEELYSELQARETFEKTPVE-- 3377

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT 2612
                    + +    G + ++   +S + F++ + + +        +R       +    
Sbjct: 3378 --------VPVGGFKGRTVTVWELISSEYFTAEQRQEL--------LRQFRTGKVTVEKV 3421

Query: 2613 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2672
            ++    I    +T   E++S +     G+   +    LL +   +          K +++
Sbjct: 3422 IKILITIVEEVETLRQERLSFS-----GLRAPVPASELLASGVLSRAQFEQLKDGKTTVK 3476

Query: 2673 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732
            D    G +       L        G      K+K+S  EA++   L        LE Q  
Sbjct: 3477 DLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAA 3531

Query: 2733 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2792
            TG LVDP  + R+   EA++ G +     ++L            P +   IS   A+ + 
Sbjct: 3532 TGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG 3591

Query: 2793 MVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSF 2850
            +V    G+RLLE A +++ G+  P +    P   +  R              S   +G F
Sbjct: 3592 LVLRQHGIRLLE-AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3650

Query: 2851 DATGNSSYSY 2860
            D   + + +Y
Sbjct: 3651 DPNTHENLTY 3660



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 3073 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3128

Query: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 3129 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3185

Query: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3186 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3245

Query: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3246 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3305

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3306 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3349

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3350 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3406

Query: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3407 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3466

Query: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3467 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3526

Query: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3527 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3586

Query: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3587 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3646

Query: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3647 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3706

Query: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3707 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3758

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3759 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3789

Query: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3790 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3842

Query: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3843 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3902

Query: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3903 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3962

Query: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3963 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 4021

Query: 2810 SKGLPSPYNM 2819
             +GL     M
Sbjct: 4022 FRGLRKQITM 4031



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075

Query: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135

Query: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195

Query: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255

Query: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315

Query: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4316 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4371

Query: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4372 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4428

Query: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4429 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4488

Query: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4489 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4533

Query: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4534 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4580

Query: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4581 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4640

Query: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
             S        S  ++T  SSS+S +
Sbjct: 4641 GS---FDATGSGFSMTFSSSSYSSS 4662


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3618 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3677

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3678 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3737

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3738 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3797

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3798 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3856

Query: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916

Query: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976

Query: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036

Query: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096

Query: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156

Query: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4157 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4216

Query: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4217 NAGGFRSRSSSVG------SSSSYPISPAVSRT--------QLASWSDPTEETGPVAGIL 4262

Query: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4263 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4322

Query: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4323 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4382

Query: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4383 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4442

Query: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4443 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4494

Query: 2864 FSSSS 2868
            FSSSS
Sbjct: 4495 FSSSS 4499



 Score =  883 bits (2282), Expect = 0.0
 Identities = 753/2950 (25%), Positives = 1369/2950 (46%), Gaps = 355/2950 (12%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 386  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 445

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 446  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 502

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 503  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 562

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 563  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 622

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 623  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 682

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 683  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 742

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 743  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 802

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 803  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 862

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 863  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 922

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 923  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 962

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 963  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1012

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1192

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1193 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1252

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1253 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1312 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1357

Query: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1358 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1401

Query: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1402 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1461

Query: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1519 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1573

Query: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1632

Query: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752

Query: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1811

Query: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871

Query: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1928

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 1981

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 1982 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 2041 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 2089 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2148

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 2149 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2207

Query: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2264

Query: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
            A       QL E  L  +  L +K+LK K                               
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2324

Query: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2384

Query: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2385 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442

Query: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502

Query: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2503 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2562

Query: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2563 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2620

Query: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2621 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2680

Query: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2681 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2740

Query: 2363 HGIRLLEAQIATGGIIDP--------------------------------------KESH 2384
               +LL A+ A  G  DP                                        SH
Sbjct: 2741 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2800

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            R+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2801 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2860

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 2861 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2904

Query: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 2905 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 2956

Query: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 2957 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3006

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 3007 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3066

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 3067 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3126

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 3127 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3186

Query: 2802 LLEAASVSSK 2811
            LL  +  +++
Sbjct: 3187 LLPLSEKAAR 3196



 Score =  543 bits (1399), Expect = e-154
 Identities = 487/1930 (25%), Positives = 908/1930 (47%), Gaps = 208/1930 (10%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1750

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1751 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1807

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867

Query: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987

Query: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 1988 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2031

Query: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 2032 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2065

Query: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 2066 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124

Query: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244

Query: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304

Query: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 2305 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364

Query: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 2365 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2424

Query: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 2425 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2484

Query: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544

Query: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+   ++ 
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT- 2603

Query: 1935 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1994
                +   R    G   E + E           FDGLR+KV+A +L E  ++    L +L
Sbjct: 2604 ----LPNGRDALDGPAAEAEPEHS---------FDGLRRKVSAQRLQEAGILSAEELQRL 2650

Query: 1995 LKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEA 2051
             +G  +V+E+A   +++ +L+G  SIAG    +  EK S+  A +++L+SP + ++LLEA
Sbjct: 2651 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEA 2710

Query: 2052 QAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAI 2111
            QAA+G ++DP RN +LTV+ A+   ++  +   ++ +AE+A+TG+ DP++G+ +S+ +A+
Sbjct: 2711 QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAM 2770

Query: 2112 KKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKN 2171
            +K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D ++ R L DP D  K 
Sbjct: 2771 QKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKG 2830

Query: 2172 FVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV---------------------QKRSMS- 2209
            F DP T + ++Y+QL ERC  +P TGL LL +                     +K ++S 
Sbjct: 2831 FFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSA 2890

Query: 2210 ----FQGIRQPVTVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
                FQG  + VT+ E+++S       R   + +  +G+I+ +++ + I         I 
Sbjct: 2891 PFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII---------IT 2939

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
             +  +  K +L  +E ++  LV    A ELLE++     ++D     +L   E   R + 
Sbjct: 2940 VVEEQEQKGRL-CFEGLR-SLV---PAAELLESR-----VIDRELYQQLQRGERSVRDVA 2989

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
             ++   + L     + G    E G  +S++ A+ K+L+     + LLEAQ  TG IIDP 
Sbjct: 2990 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPA 3049

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
             S RL VD A + G    E  E L        G+ DP T ++++  Q  ++ +   E GL
Sbjct: 3050 TSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGL 3109

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVI----VDPETNKEMSVQEAYKKGLIDYET----- 2492
             LL  +     +    K+      V      +D ET++ +S   A  K   D  T     
Sbjct: 3110 RLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPAT 3169

Query: 2493 FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSL 2552
            + EL +Q C  +++T     G + + L ++   ++   Q+ +   L  R+ F++      
Sbjct: 3170 YGEL-QQRCRPDQLT-----GLSLLPLSEKAARAR---QEELYSELQARETFEKTPVE-- 3218

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT 2612
                    + +    G + ++   +S + F++ + + +        +R       +    
Sbjct: 3219 --------VPVGGFKGRTVTVWELISSEYFTAEQRQEL--------LRQFRTGKVTVEKV 3262

Query: 2613 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2672
            ++    I    +T   E++S +     G+   +    LL +   +          K +++
Sbjct: 3263 IKILITIVEEVETLRQERLSFS-----GLRAPVPASELLASGVLSRAQFEQLKDGKTTVK 3317

Query: 2673 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732
            D    G +       L        G      K+K+S  EA++   L        LE Q  
Sbjct: 3318 DLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAA 3372

Query: 2733 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2792
            TG LVDP  + R+   EA++ G +     ++L            P +   IS   A+ + 
Sbjct: 3373 TGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG 3432

Query: 2793 MVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSF 2850
            +V    G+RLLE A +++ G+  P +    P   +  R              S   +G F
Sbjct: 3433 LVLRQHGIRLLE-AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3491

Query: 2851 DATGNSSYSY 2860
            D   + + +Y
Sbjct: 3492 DPNTHENLTY 3501



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2914 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2969

Query: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2970 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3026

Query: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3027 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3086

Query: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3087 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3146

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3147 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3190

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3191 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3247

Query: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3248 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3307

Query: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3308 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3367

Query: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3368 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3427

Query: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3428 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3487

Query: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3488 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3547

Query: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3548 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3599

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3600 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3630

Query: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3631 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3683

Query: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3684 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3743

Query: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3744 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3803

Query: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3804 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3862

Query: 2810 SKGLPSPYNM 2819
             +GL     M
Sbjct: 3863 FRGLRKQITM 3872



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916

Query: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976

Query: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036

Query: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096

Query: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156

Query: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4157 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4212

Query: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4213 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4269

Query: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4270 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4329

Query: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4330 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4374

Query: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4375 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4421

Query: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4422 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4481

Query: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
             S        S  ++T  SSS+S +
Sbjct: 4482 GS---FDATGSGFSMTFSSSSYSSS 4503


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3626 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3685

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3686 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3745

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3746 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3805

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3806 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3864

Query: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3865 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3924

Query: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3925 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3984

Query: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 3985 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4044

Query: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4045 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4104

Query: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4105 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4164

Query: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4165 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4224

Query: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4225 NAGGFRSRSSSVG------SSSSYPISPAVSRT--------QLASWSDPTEETGPVAGIL 4270

Query: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4271 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4330

Query: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4331 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4390

Query: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4391 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4450

Query: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4451 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4502

Query: 2864 FSSSS 2868
            FSSSS
Sbjct: 4503 FSSSS 4507



 Score =  883 bits (2282), Expect = 0.0
 Identities = 753/2950 (25%), Positives = 1369/2950 (46%), Gaps = 355/2950 (12%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 394  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 453

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 454  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 510

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 511  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 570

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 571  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 630

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 631  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 690

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 691  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 750

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 751  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 810

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 811  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 870

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 871  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 930

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 931  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 970

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 971  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1020

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1021 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1080

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1140

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1141 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1200

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1201 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1260

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1261 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1320 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1365

Query: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1366 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1409

Query: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1410 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1469

Query: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1527 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1581

Query: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1640

Query: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1701 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1760

Query: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1819

Query: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1820 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1879

Query: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 1880 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1936

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 1937 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 1989

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 1990 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2048

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 2049 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 2097 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2156

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 2157 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2215

Query: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2272

Query: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
            A       QL E  L  +  L +K+LK K                               
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2332

Query: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 2333 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2392

Query: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2393 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2450

Query: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2451 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2510

Query: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2511 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2570

Query: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2571 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2628

Query: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2629 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2688

Query: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2689 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2748

Query: 2363 HGIRLLEAQIATGGIIDP--------------------------------------KESH 2384
               +LL A+ A  G  DP                                        SH
Sbjct: 2749 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2808

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            R+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2809 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2868

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 2869 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2912

Query: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 2913 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 2964

Query: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 2965 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3014

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 3015 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3074

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 3075 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3134

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 3135 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3194

Query: 2802 LLEAASVSSK 2811
            LL  +  +++
Sbjct: 3195 LLPLSEKAAR 3204



 Score =  543 bits (1399), Expect = e-154
 Identities = 487/1930 (25%), Positives = 908/1930 (47%), Gaps = 208/1930 (10%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1758

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1759 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1815

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1875

Query: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995

Query: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 1996 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2039

Query: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 2040 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2073

Query: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 2074 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132

Query: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252

Query: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2312

Query: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 2313 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2372

Query: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 2373 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2432

Query: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 2433 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2492

Query: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552

Query: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+   ++ 
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT- 2611

Query: 1935 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1994
                +   R    G   E + E           FDGLR+KV+A +L E  ++    L +L
Sbjct: 2612 ----LPNGRDALDGPAAEAEPEHS---------FDGLRRKVSAQRLQEAGILSAEELQRL 2658

Query: 1995 LKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEA 2051
             +G  +V+E+A   +++ +L+G  SIAG    +  EK S+  A +++L+SP + ++LLEA
Sbjct: 2659 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEA 2718

Query: 2052 QAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAI 2111
            QAA+G ++DP RN +LTV+ A+   ++  +   ++ +AE+A+TG+ DP++G+ +S+ +A+
Sbjct: 2719 QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAM 2778

Query: 2112 KKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKN 2171
            +K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D ++ R L DP D  K 
Sbjct: 2779 QKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKG 2838

Query: 2172 FVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV---------------------QKRSMS- 2209
            F DP T + ++Y+QL ERC  +P TGL LL +                     +K ++S 
Sbjct: 2839 FFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSA 2898

Query: 2210 ----FQGIRQPVTVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
                FQG  + VT+ E+++S       R   + +  +G+I+ +++ + I         I 
Sbjct: 2899 PFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII---------IT 2947

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
             +  +  K +L  +E ++  LV    A ELLE++     ++D     +L   E   R + 
Sbjct: 2948 VVEEQEQKGRL-CFEGLR-SLV---PAAELLESR-----VIDRELYQQLQRGERSVRDVA 2997

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
             ++   + L     + G    E G  +S++ A+ K+L+     + LLEAQ  TG IIDP 
Sbjct: 2998 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPA 3057

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
             S RL VD A + G    E  E L        G+ DP T ++++  Q  ++ +   E GL
Sbjct: 3058 TSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGL 3117

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVI----VDPETNKEMSVQEAYKKGLIDYET----- 2492
             LL  +     +    K+      V      +D ET++ +S   A  K   D  T     
Sbjct: 3118 RLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPAT 3177

Query: 2493 FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSL 2552
            + EL +Q C  +++T     G + + L ++   ++   Q+ +   L  R+ F++      
Sbjct: 3178 YGEL-QQRCRPDQLT-----GLSLLPLSEKAARAR---QEELYSELQARETFEKTPVE-- 3226

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT 2612
                    + +    G + ++   +S + F++ + + +        +R       +    
Sbjct: 3227 --------VPVGGFKGRTVTVWELISSEYFTAEQRQEL--------LRQFRTGKVTVEKV 3270

Query: 2613 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2672
            ++    I    +T   E++S +     G+   +    LL +   +          K +++
Sbjct: 3271 IKILITIVEEVETLRQERLSFS-----GLRAPVPASELLASGVLSRAQFEQLKDGKTTVK 3325

Query: 2673 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732
            D    G +       L        G      K+K+S  EA++   L        LE Q  
Sbjct: 3326 DLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAA 3380

Query: 2733 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2792
            TG LVDP  + R+   EA++ G +     ++L            P +   IS   A+ + 
Sbjct: 3381 TGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG 3440

Query: 2793 MVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSF 2850
            +V    G+RLLE A +++ G+  P +    P   +  R              S   +G F
Sbjct: 3441 LVLRQHGIRLLE-AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3499

Query: 2851 DATGNSSYSY 2860
            D   + + +Y
Sbjct: 3500 DPNTHENLTY 3509



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2922 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2977

Query: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 2978 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3034

Query: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3035 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3094

Query: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3095 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3154

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3155 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3198

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3199 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3255

Query: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3256 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3315

Query: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3316 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3375

Query: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3376 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3435

Query: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3436 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3495

Query: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3496 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3555

Query: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3556 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3607

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3608 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3638

Query: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3639 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3691

Query: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3692 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3751

Query: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3752 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3811

Query: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3812 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3870

Query: 2810 SKGLPSPYNM 2819
             +GL     M
Sbjct: 3871 FRGLRKQITM 3880



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3865 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3924

Query: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3925 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3984

Query: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 3985 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4044

Query: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4045 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4104

Query: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4105 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4164

Query: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4165 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4220

Query: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4221 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4277

Query: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4278 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4337

Query: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4338 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4382

Query: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4383 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4429

Query: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4430 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4489

Query: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
             S        S  ++T  SSS+S +
Sbjct: 4490 GS---FDATGSGFSMTFSSSSYSSS 4511


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 3667 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3726

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 3727 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3786

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 3787 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3846

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 3847 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3905

Query: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965

Query: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025

Query: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085

Query: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145

Query: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205

Query: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 4206 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4265

Query: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 4266 NAGGFRSRSSSVG------SSSSYPISPAVSRT--------QLASWSDPTEETGPVAGIL 4311

Query: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 4312 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4371

Query: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 4372 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4431

Query: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 4432 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4491

Query: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 4492 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4543

Query: 2864 FSSSS 2868
            FSSSS
Sbjct: 4544 FSSSS 4548



 Score =  883 bits (2282), Expect = 0.0
 Identities = 753/2950 (25%), Positives = 1369/2950 (46%), Gaps = 355/2950 (12%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 435  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 494

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 495  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 551

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 552  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 611

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 612  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 671

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 672  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 731

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 732  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 791

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 792  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 851

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 852  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 911

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 912  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 971

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 972  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1011

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 1012 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1061

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1122 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1181

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1182 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1241

Query: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 1242 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1301

Query: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 1302 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1361 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1406

Query: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1407 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1450

Query: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1510

Query: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1568 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1622

Query: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1681

Query: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741

Query: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1742 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1801

Query: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1802 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1860

Query: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1920

Query: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 1921 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1977

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 1978 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 2030

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 2031 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 2090 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 2138 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2197

Query: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 2198 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2256

Query: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2313

Query: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998
            A       QL E  L  +  L +K+LK K                               
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2373

Query: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2433

Query: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2434 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2491

Query: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551

Query: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2552 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2611

Query: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2612 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2669

Query: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2670 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2729

Query: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2730 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2789

Query: 2363 HGIRLLEAQIATGGIIDP--------------------------------------KESH 2384
               +LL A+ A  G  DP                                        SH
Sbjct: 2790 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2849

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            R+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2850 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2909

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 2910 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2953

Query: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 2954 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 3005

Query: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 3006 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3055

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 3056 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3115

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 3116 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3175

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 3176 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3235

Query: 2802 LLEAASVSSK 2811
            LL  +  +++
Sbjct: 3236 LLPLSEKAAR 3245



 Score =  543 bits (1399), Expect = e-154
 Identities = 487/1930 (25%), Positives = 908/1930 (47%), Gaps = 208/1930 (10%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1799

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1800 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1856

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916

Query: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036

Query: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 2037 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2080

Query: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 2081 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2114

Query: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 2115 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173

Query: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293

Query: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2353

Query: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 2354 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2413

Query: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 2414 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2473

Query: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 2474 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2533

Query: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593

Query: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSR 1934
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+   ++ 
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT- 2652

Query: 1935 YQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKL 1994
                +   R    G   E + E           FDGLR+KV+A +L E  ++    L +L
Sbjct: 2653 ----LPNGRDALDGPAAEAEPEHS---------FDGLRRKVSAQRLQEAGILSAEELQRL 2699

Query: 1995 LKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEA 2051
             +G  +V+E+A   +++ +L+G  SIAG    +  EK S+  A +++L+SP + ++LLEA
Sbjct: 2700 AQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEA 2759

Query: 2052 QAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAI 2111
            QAA+G ++DP RN +LTV+ A+   ++  +   ++ +AE+A+TG+ DP++G+ +S+ +A+
Sbjct: 2760 QAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAM 2819

Query: 2112 KKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKN 2171
            +K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D ++ R L DP D  K 
Sbjct: 2820 QKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKG 2879

Query: 2172 FVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV---------------------QKRSMS- 2209
            F DP T + ++Y+QL ERC  +P TGL LL +                     +K ++S 
Sbjct: 2880 FFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSA 2939

Query: 2210 ----FQGIRQPVTVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
                FQG  + VT+ E+++S       R   + +  +G+I+ +++ + I         I 
Sbjct: 2940 PFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII---------IT 2988

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
             +  +  K +L  +E ++  LV    A ELLE++     ++D     +L   E   R + 
Sbjct: 2989 VVEEQEQKGRL-CFEGLR-SLV---PAAELLESR-----VIDRELYQQLQRGERSVRDVA 3038

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
             ++   + L     + G    E G  +S++ A+ K+L+     + LLEAQ  TG IIDP 
Sbjct: 3039 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPA 3098

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
             S RL VD A + G    E  E L        G+ DP T ++++  Q  ++ +   E GL
Sbjct: 3099 TSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGL 3158

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVI----VDPETNKEMSVQEAYKKGLIDYET----- 2492
             LL  +     +    K+      V      +D ET++ +S   A  K   D  T     
Sbjct: 3159 RLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPAT 3218

Query: 2493 FKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSL 2552
            + EL +Q C  +++T     G + + L ++   ++   Q+ +   L  R+ F++      
Sbjct: 3219 YGEL-QQRCRPDQLT-----GLSLLPLSEKAARAR---QEELYSELQARETFEKTPVE-- 3267

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT 2612
                    + +    G + ++   +S + F++ + + +        +R       +    
Sbjct: 3268 --------VPVGGFKGRTVTVWELISSEYFTAEQRQEL--------LRQFRTGKVTVEKV 3311

Query: 2613 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2672
            ++    I    +T   E++S +     G+   +    LL +   +          K +++
Sbjct: 3312 IKILITIVEEVETLRQERLSFS-----GLRAPVPASELLASGVLSRAQFEQLKDGKTTVK 3366

Query: 2673 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2732
            D    G +       L        G      K+K+S  EA++   L        LE Q  
Sbjct: 3367 DLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAA 3421

Query: 2733 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2792
            TG LVDP  + R+   EA++ G +     ++L            P +   IS   A+ + 
Sbjct: 3422 TGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKG 3481

Query: 2793 MVEDITGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSF 2850
            +V    G+RLLE A +++ G+  P +    P   +  R              S   +G F
Sbjct: 3482 LVLRQHGIRLLE-AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFF 3540

Query: 2851 DATGNSSYSY 2860
            D   + + +Y
Sbjct: 3541 DPNTHENLTY 3550



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 2963 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3018

Query: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 3019 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3075

Query: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 3076 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3135

Query: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 3136 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3195

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 3196 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3239

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 3240 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3296

Query: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 3297 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3356

Query: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 3357 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3416

Query: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 3417 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3476

Query: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 3477 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3536

Query: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 3537 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3596

Query: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 3597 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3648

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 3649 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3679

Query: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 3680 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3732

Query: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 3733 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3792

Query: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 3793 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3852

Query: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 3853 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3911

Query: 2810 SKGLPSPYNM 2819
             +GL     M
Sbjct: 3912 FRGLRKQITM 3921



 Score =  259 bits (663), Expect = 2e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 3906 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3965

Query: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 3966 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4025

Query: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 4026 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4085

Query: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 4086 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4145

Query: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 4146 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4205

Query: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 4206 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4261

Query: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 4262 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4318

Query: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 4319 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4378

Query: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 4379 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4423

Query: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 4424 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4470

Query: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 4471 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4530

Query: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612
             S        S  ++T  SSS+S +
Sbjct: 4531 GS---FDATGSGFSMTFSSSSYSSS 4552


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score =  783 bits (2021), Expect = 0.0
 Identities = 619/2466 (25%), Positives = 1159/2466 (46%), Gaps = 302/2466 (12%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085

Query: 1008 TRSGDYYRFLSEMLKSLEDLKLK------------------------NTKI--------- 1034
            T    Y +F  + LK LE+ ++K                        N+K+         
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELER 1145

Query: 1035 ---------EVLEEELRLARDANSENCNKNK--FLDQNLQKYQA--ECSQFKAKLASLEE 1081
                       +EEEL   R+A      K +    D +LQK +A  E  Q++ +L ++  
Sbjct: 1146 MVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVR 1205

Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---------- 1131
             K  AE + +  +Q   +   +   + E +     ++E+    R+++ED           
Sbjct: 1206 EKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLND 1265

Query: 1132 FDQQKND-YDQLQKARQCEKE----------NLGWQKLESEKAIKEKE-YEIERLRVLLQ 1179
             +QQKN   ++L++ R  E+E          +L +QK  +EK +KEK+  E+E  R + +
Sbjct: 1266 LEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITE 1325

Query: 1180 EEGT----------------------RKREYENELAKVRNHYNEEMSNLRNKYETEINIT 1217
             + T                       ++E++ + A+      +E++    K E ++   
Sbjct: 1326 IQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMREL 1385

Query: 1218 KTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENA 1274
               +  + ++K   E+ ++ L+++LD  +   R LK E+ R + +    ++Q R      
Sbjct: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445

Query: 1275 LQQKACGSEIMQK-------KQHLEIELKQVMQQRSE---DNARHKQSLEEAAKTIQDKN 1324
             Q      E MQ+       K++ ++EL+ +  ++ +   +  R  ++   A K IQ  N
Sbjct: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLN 1505

Query: 1325 ---------KEIERLKA------EFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETE 1369
                     KE+ERL+         +E+ ++  E   +  K     +++I  L  + E  
Sbjct: 1506 SQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKS 1565

Query: 1370 ---INITKTTIHQLTMQKEED---TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENL 1423
                 + K  + +LT Q  E        +A+ +N+  E +++ +  + LK       + L
Sbjct: 1566 NECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQL 1625

Query: 1424 RRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEI 1483
            R   E + +Q  T  +  ++ + LE +L +   + +E    +KQ  D     IQ+  KE+
Sbjct: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSE----FKQKCDQQNIIIQNTKKEV 1681

Query: 1484 ERLKQLIDKETNDRK-----------CLEDENARLQRVQYDLQKANSSATETINKLKVQE 1532
              L   ++    +++            +++ N RL++VQ +L         T  K+ + +
Sbjct: 1682 RNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQ 1741

Query: 1533 QELTRLRIDYE--RVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCK 1590
            +E  + +   E  R   E+ ++ + IT  +N +  ++L    +++E +R +  A      
Sbjct: 1742 EESGKFKQSAEEFRKKMEKLMESKVIT--ENDISGIRLDFVSLQQENSRAQENAKLCETN 1799

Query: 1591 RKKLEEELEGMRRSLKEQAIKITN---LTQQLEQASIVKKRSEDDLRQQRDVLDGHLREK 1647
             K+LE +L+  R  +++      N     Q+LE   I +KR  ++L+Q+ D        +
Sbjct: 1800 IKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMD--------Q 1851

Query: 1648 QRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE----SKIEI 1703
            Q  + E + +  + E  ++   ++        +  +  Q + E  SR+        +  +
Sbjct: 1852 QIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPL 1911

Query: 1704 ERLQSLTENLTK--EHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNN 1761
             R     + L +  +H ++E+  + ++ +       + ++    +    +  ++LQI+ +
Sbjct: 1912 LRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPGAPLEKEKSQQCYSEYFSQTSTELQITFD 1971

Query: 1762 RTLELQGLINDLQRERENLRQEIEKFQKQALEASN-RIQESKNQCTQVV----------- 1809
             T  +  L             EIEK + QAL  S   ++   N C   +           
Sbjct: 1972 ETNPITRL------------SEIEKIRDQALNNSRPPVRYQDNACEMELVKVLTPLEIAK 2019

Query: 1810 QERESLLVKIKVLEQDKARLQRLED---ELNRAKSTLEAETRVKQRLECEK-QQIQNDLN 1865
             ++  +  ++  L+Q+K  +   E+   E  RA   L+    +K+ LE E  Q    D  
Sbjct: 2020 NKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLKKGDFLKKGLEPETFQNFDGDHA 2079

Query: 1866 QWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQ 1925
                    K + +R   + R+  E +   +R+ IE+L+  +K +EE          ++T 
Sbjct: 2080 CSVRDDEFKFQGLRHTVTARQLVEAKLLDMRT-IEQLRLGLKTVEE---------VQKTL 2129

Query: 1926 SQLETERSRYQREIDKLRQRPYGSHRE-TQTECEWTVDTSKLVFDGLRKKVTAMQLYECQ 1984
            ++  T+ +              G + E T+ +  +     +++ D    K+ A+   E Q
Sbjct: 2130 NKFLTKATSIA-----------GLYLESTKEKISFASAAERIIID----KMVALAFLEAQ 2174

Query: 1985 LIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKK 2038
                  +D +     SVE+      V  E +  L  A   A   +   +  S+ +A   +
Sbjct: 2175 AATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSYSSKTLSVFQAMENR 2234

Query: 2039 LISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDD 2098
            ++  +    +LEAQ A+GG+IDP R  ++  + A+ + L++    Q ++        F +
Sbjct: 2235 MLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPN 2294

Query: 2099 PFSGKTVSVSEAIKKNLIDRETGMRLL---EAQIAS--------GGVVDPVNSVFLPKDV 2147
            P + + +  SE ++  + D E+   L    E  I++          VVD      L    
Sbjct: 2295 PNNKQALYYSELLRMCVFDVESQCFLFPFGERNISNLNVKKTHRISVVDTKTGSELTVYE 2354

Query: 2148 ALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH-TGLLLLSVQKR 2206
            A  R LI++ +Y  L+  +                  Q KE    E +     +L+  K 
Sbjct: 2355 AFQRNLIEKSIYLELSGQQ-----------------YQWKEAMFFESYGHSSHMLTDTKT 2397

Query: 2207 SMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGS----SCIAG 2262
             + F        + E ++ G +  + V + + G I+  E+ + +   L       S +AG
Sbjct: 2398 GLHF-------NINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAG 2450

Query: 2263 IYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVG 2322
             +   + +++ + +A +  LV   TAL  LEAQ +TG I+DP++  +  V EA  RGLV 
Sbjct: 2451 YWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVD 2510

Query: 2323 IEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKE 2382
              F ++L   E  +TG   P T  ++S+ +A+N  +I K  GIR LE Q  TGG+I+P+ 
Sbjct: 2511 EGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQV 2570

Query: 2383 SHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLC 2442
              RL ++ A + G  +  ++  L D     +    P T+  LTY +  E+   D  TGL 
Sbjct: 2571 HSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLK 2630

Query: 2443 LLPLKE 2448
            LL + E
Sbjct: 2631 LLEVSE 2636



 Score =  377 bits (969), Expect = e-104
 Identities = 218/619 (35%), Positives = 346/619 (55%), Gaps = 50/619 (8%)

Query: 2202 SVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
            SV+     FQG+R  VT  +LV++ +L   T+ +L  G  + +EV + +  FL  ++ IA
Sbjct: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIA 2140

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
            G+Y E+TK+K+    A +  ++    AL  LEAQAATGFI+DP+S     VE+A  +G+V
Sbjct: 2141 GLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVV 2200

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
              EF+ +LL AE+A  GY+   +   +S+FQAM   ++++  G  +LEAQIA+GG+IDP 
Sbjct: 2201 DPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPV 2258

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGL 2441
               R+P +IA ++G  N  + + L +PS +T+ F +PN ++ L Y +L   C+ D E+  
Sbjct: 2259 RGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQC 2318

Query: 2442 CLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQEC 2501
             L P  E+      S  N  +  R+ +VD +T  E++V EA+++ LI+   + EL  Q+ 
Sbjct: 2319 FLFPFGERN----ISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQY 2374

Query: 2502 EWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 2561
            +W+E     S G +  +L D KTG  ++I +AI++G +D+    +Y+ G ++LT+ AD  
Sbjct: 2375 QWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELAD-- 2432

Query: 2562 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
                                         S +S +   ++L              SP+A 
Sbjct: 2433 -----------------------------SLLSRLVPKKDL-------------HSPVAG 2450

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
             + T + E+IS+ +   R +VD IT  R LEAQ  TGGII P TG+K  + +A+ +G++D
Sbjct: 2451 YWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVD 2510

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
            +  A +L+  +    G       K MS  EAV    +  E G R LEFQYLTGGL++P+V
Sbjct: 2511 EGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQV 2570

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
            H R+S EEA++ G ID   A +L+D  SY + + CP+TK K++YK+A+ ++  +  TGL+
Sbjct: 2571 HSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLK 2630

Query: 2802 LLEAASVSSKGLPSPYNMS 2820
            LLE +     G+ S Y  S
Sbjct: 2631 LLEVSEPLMTGISSLYYSS 2649



 Score =  124 bits (311), Expect = 1e-27
 Identities = 93/289 (32%), Positives = 145/289 (50%), Gaps = 12/289 (4%)

Query: 1923 ETQSQLETERSRYQ-REIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLY 1981
            E    LE    +YQ +E        + SH  T T+     + ++ +  G   K    + Y
Sbjct: 2362 EKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKK-Y 2420

Query: 1982 ECQLIDKTTL-DKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLI 2040
            +  LI  T L D LL      +++ S +      AG    AS    E+ S+++A R+ L+
Sbjct: 2421 QEGLITLTELADSLLSRLVPKKDLHSPV------AGYWLTASG---ERISVLKASRRNLV 2471

Query: 2041 SPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPF 2100
               + +  LEAQ +TGGIIDP   +K  V  A+ R L+D    QQ+   E  ITG   P 
Sbjct: 2472 DRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGIGHPI 2531

Query: 2101 SGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYR 2160
            + K +SV EA+  N+I++E G+R LE Q  +GG+++P     L  + AL  G+ID  +  
Sbjct: 2532 TNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDVLIAT 2591

Query: 2161 SLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMS 2209
             L D +   +N + P TK+K++Y +  E+   + HTGL LL V +  M+
Sbjct: 2592 KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMT 2640


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  609 bits (1571), Expect = e-173
 Identities = 460/1803 (25%), Positives = 884/1803 (49%), Gaps = 168/1803 (9%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 630  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 689

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 690  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 750  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 809

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 810  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 869

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 870  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 929

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 930  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 989

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 990  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1049

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 1050 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1081

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 1082 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1140

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 1141 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1200

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 1201 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1260

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 1261 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1320

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 1321 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1380

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1381 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1440

Query: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067
            T    Y +F  + LK LE            EEE               K L++  +++  
Sbjct: 1441 TLMTQYIKFAGDSLKRLE------------EEE---------------KSLEEEKKEHVE 1473

Query: 1068 ECSQFKAKLASLEELKRQAELDGKS--AKQNLDKCYGQIKELNEKITRLTYEIED-EKRR 1124
            +  + +  ++++ +  + AE  GK   +KQ +       +E++ K  +L+  ++  +   
Sbjct: 1474 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS-----EEISTKKEQLSEALQTIQLFL 1528

Query: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
             K  +   D+++N+ ++  K  Q E  NL +   ES K ++E +   + ++V  +    R
Sbjct: 1529 AKHGDKMTDEERNELEKQVKTLQ-ESYNLLFS--ESLKQLQESQTSGD-VKVEEKIVAER 1584

Query: 1185 KREYENELAKVRNHYNEEMSNLRNKYET-EINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
            ++EY+ +L  + +   +  + L    E   I      +K+   ++E+  K+++     L+
Sbjct: 1585 QQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA 1644

Query: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS 1303
                    E+V+  ++ L+   ++   E+ AL        I QK    +I+ +Q+     
Sbjct: 1645 --------EVVKNTENFLKENGEKLSQEDKAL--------IEQKLNEAKIKCEQL----- 1683

Query: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN-NYDEEIISL 1362
              N + +QS +E  K +    KE     A  ++  + + + EN L  + N + D E    
Sbjct: 1684 --NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1741

Query: 1363 KNQFETEINIT--KTTIHQLTMQKEEDTSGYRAQID-----NLTRENRSLSEEIKRLKNT 1415
            K++   E N T  +    +  + +E++ +G   + D       T+EN  L+++ +++K  
Sbjct: 1742 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN--LNQQYQKVK-- 1797

Query: 1416 LTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE-SVRYKQSLDDAAK 1474
              Q  + + + +  I   ++    + ++ Q L  E ++  Q   +E  V Y+ +L ++ K
Sbjct: 1798 -AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1856

Query: 1475 TIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ- 1533
             ++  +   E L++     T     L+     L+ ++      N   T+   +    E  
Sbjct: 1857 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1916

Query: 1534 -----ELTRLRIDYERVSQ-ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASED 1587
                 +L  + I   RV +  ++   +D  +   S    ++Q+ K++   +R +   S+ 
Sbjct: 1917 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQR-KLDHATDRFRSLYSKC 1975

Query: 1588 SCKRKKLEEELE----------GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQR 1637
            +     L++ ++          G+   L  QA + T      E  ++  K  +  L + +
Sbjct: 1976 NVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQLEETK 2033

Query: 1638 DVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697
              L G +  +Q   E+L++ +  +   R  LL  +  +++     +      ED S+S+N
Sbjct: 2034 -ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT---LDDIVGRYEDLSKSVN 2089

Query: 1698 ESKIEIERLQ-SLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756
            E     E+LQ +LT +L+ +   L+E L  +      L   + +     N+T L    Q 
Sbjct: 2090 ERN---EKLQITLTRSLSVQD-GLDEMLDWMGNVESSL---KEQGQVPLNSTAL----QD 2138

Query: 1757 QISNNRTLE--LQGLINDLQRERENLRQEIE--------KFQKQALEASNRIQESKNQCT 1806
             IS N  LE  + G  + +    E +++ +E          Q +  + S R  E+ ++  
Sbjct: 2139 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2198

Query: 1807 QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ 1866
            + + + E L  K+++ E    +LQ   +   +A + ++   +    L    Q+  ++  +
Sbjct: 2199 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2258

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K         +++I S    S  +K  +  +   L  + K +E+  + K E  T   Q 
Sbjct: 2259 HKKHLEVLHSLLKEISSHGLPS--DKALVLEKTNNLSKKFKEMEDTIKEKKEAVT-SCQE 2315

Query: 1927 QLE 1929
            QL+
Sbjct: 2316 QLD 2318



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 231/1243 (18%), Positives = 489/1243 (39%), Gaps = 199/1243 (16%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 3294 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3344

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 3345 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3403

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3404 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3456

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL------------ 1058
             ++   + + L + E +    T+   LEE++   +    +  N NK L            
Sbjct: 3457 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3513

Query: 1059 -----DQNLQKYQAECSQ-----FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                 D+++ + + + SQ      + K  S  EL +QA  + K   ++  +    + E++
Sbjct: 3514 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3573

Query: 1109 EKITRLT---YEIE----DEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL--- 1158
            +K+++L+   Y  E     +   R   ED   +++N    L    +  K+  G + L   
Sbjct: 3574 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3633

Query: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK 1218
            +  +AIK +  +I +    L  +  +  E   +LA+  +  +EE+    +K E E+   +
Sbjct: 3634 DKLEAIKARYKDITK----LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3689

Query: 1219 TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR-------AE 1271
            T +  +  ++   ++    +L + ++ N+ L D +  ++ ++L+    R R       AE
Sbjct: 3690 TQV--LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3747

Query: 1272 ENALQQKACGSEIMQKKQHLEIEL--KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
            +N  + +     I QK + ++  +   Q   Q ++         E+   ++ D   E ++
Sbjct: 3748 DNE-RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3806

Query: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
              A+ Q               V+  +  EI+  K+  +   ++ K+    +T   EE+  
Sbjct: 3807 TSAQLQ---------------VQKTFTMEILRHKDIID---DLVKSGHKIMTACSEEEKQ 3848

Query: 1390 GYRAQIDNLTRENRSLSE-------EIKRLKNTLTQTTEN-------LRRVEEDIQQQKA 1435
              + ++D + +   ++ +       +++R ++ + Q  E        L   +  I Q  A
Sbjct: 3849 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3908

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT--------------IQDKNK 1481
               E    +QQ E E RQ+ ++  E    +K  +D   KT              IQ+K  
Sbjct: 3909 PALEYETLRQQQE-EHRQLRELIAE----HKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3963

Query: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQY--DLQKANSSATETINKLKVQEQELTRLR 1539
              + L   I ++   R    DE A  Q  Q+   + +   S    + +L+        + 
Sbjct: 3964 AADTLYSQIKEDVKKRAVALDE-AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVE 4022

Query: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCK--RKKLEEE 1597
               E++S+ + V   D+ + Q   + L   KQ+ EE + R   T  + S K  + KL++ 
Sbjct: 4023 KIKEQISENKNV-SVDMEKLQPLYETL---KQRGEEMIARSGGTDKDISAKAVQDKLDQM 4078

Query: 1598 L---EGMRRSLKEQAIKITNLTQQLEQ-------ASIVKKRSEDDLRQQRDV-LDGHLRE 1646
            +   E +   ++E+  K+ ++ +  E+         +  K ++D +R   D  +D  + +
Sbjct: 4079 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4138

Query: 1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL 1706
            +Q  QE    +  E++ L+ +L    + V   +L +E      E     + +S  E+   
Sbjct: 4139 QQ--QEAAETIREEIDGLQEEL----DIV--INLGSELIAACGEPDKPIVKKSIDELNSA 4190

Query: 1707 QSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766
                    K+ +   EE     ++Y D               +  +   + I+  +   +
Sbjct: 4191 WDSLNKAWKDRIDKLEEAMQAAVQYQD--------------GLQAVFDWVDIAGGKLASM 4236

Query: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
              +  DL+  ++ + +E+++F+ +A +    ++   +Q          LL+K    E DK
Sbjct: 4237 SPIGTDLETVKQQI-EELKQFKSEAYQQQIEMERLNHQA--------ELLLKKVTEESDK 4287

Query: 1827 ARLQRLEDELNRAKSTLEAETRVKQ-RLE------CEKQQIQNDLNQWKTQYSRKEEAIR 1879
              +Q    EL     +LE     +Q +LE       + Q   ++L  W T         +
Sbjct: 4288 HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQK 4347

Query: 1880 KIESEREKSERE---KNSLRSEIERLQAEIKRIEERCRRKLEDSTRE----TQSQLETER 1932
             +  + +  E E    + L++++   Q+ ++ + +     +E S  E     Q++LE   
Sbjct: 4348 PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLN 4407

Query: 1933 SRYQREIDKLRQRPY----------GSHRETQTECEWTVDTSK 1965
             R+Q  ++K  QR            G H E +   +W  DT +
Sbjct: 4408 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 234/1345 (17%), Positives = 513/1345 (38%), Gaps = 173/1345 (12%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2494 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2553

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2554 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2608

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE   A+    L      P  R +++     
Sbjct: 2609 -------------QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2655

Query: 992  ILQ-------EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK-------NTKIEVL 1037
            + Q       + +D      + + +S  Y   L  +   L DL  K       +T  + +
Sbjct: 2656 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2715

Query: 1038 EEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLAS---LEELKRQAELDGKSAK 1094
             ++L  A+    E   + K     ++  QA C    A +       EL RQ E   KS K
Sbjct: 2716 NQQLETAQKMKQEIQQEKK----QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2771

Query: 1095 QNLDKCYGQIKELN---------EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA 1145
                K    ++ L          ++++R      D K+  ++       + +  + L K 
Sbjct: 2772 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2831

Query: 1146 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH---YNEE 1202
             +   + L  Q    EK I E E       +LL+ +G+ K   + +L  ++ +   +N++
Sbjct: 2832 HKDFSKTLTAQSHMYEKTIAEGE------NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2885

Query: 1203 MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKD--EIVRLNDSI 1260
            +    NK +  +        E +++ ++  + L   +D+      ++K   +     +SI
Sbjct: 2886 VKERENKLKESL--------EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI 2937

Query: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
             +    ++  +++    +   +         EI+ + V    +++N    Q ++   + +
Sbjct: 2938 AKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV----TDENKSLIQKVDMVTEQL 2993

Query: 1321 QDKNKEIERLKAEFQE------EAKRRWEYENELSKVRNNYDEEIISLK--NQFETEINI 1372
              K   +E +  +F+E      E+KR+ +   E   + ++   +  S K     +T+   
Sbjct: 2994 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3053

Query: 1373 TKTTIHQLTMQK------------EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTT 1420
             +   HQ+ + K             + TS    Q++ + +E+ +LS+++    + L    
Sbjct: 3054 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3113

Query: 1421 ENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKN 1480
            + +   +  I+       E+  +  + + EL  +  +  +     KQ      +TI+   
Sbjct: 3114 QGIGHFQNTIR-------EMFSQFAEFDDELDSMAPVGRDAETLQKQK-----ETIKAFL 3161

Query: 1481 KEIERLKQLIDKETNDRKCL---EDENARLQRVQYDLQKANSSATETINKLKVQEQE--- 1534
            K++E L    D      K +   E+ +  L  ++ DL+  +    + +++ + +E++   
Sbjct: 3162 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3221

Query: 1535 -LTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK 1593
             + RL   Y ++ +E ++  Q     + S   + ++ + + ++LN  K    E+    + 
Sbjct: 3222 TIKRLEEFYSKL-KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 3280

Query: 1594 LEEELEGMRRSLKEQAIKITN---LTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRT 1650
             ++++  + + L + A K T+   L   L+  +   K     + Q+   L   L    R 
Sbjct: 3281 KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRF 3340

Query: 1651 QEELRRLSS------EVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIE 1704
            Q+ L  L S      E+ A ++    E + VK      +  Q+ ++D+  ++   K E E
Sbjct: 3341 QDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE 3400

Query: 1705 RLQSLTENLTK--------------EHLMLEEELRNLRLEYDDLRRGRSEADSDKNATIL 1750
            ++ +  E   K              E L+ + E RN +LE      G S      + T+ 
Sbjct: 3401 KIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLE------GISVVAQQFHETLE 3454

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE--SKNQCTQV 1808
             L   L     R +  + +     +  E + Q  +  +   +  +  + +  S  Q  +V
Sbjct: 3455 PLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH-KALEDDIINHNKHLHQAVSIGQSLKV 3513

Query: 1809 VQERE-----------SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEK 1857
            +  RE           S +  I++ E+  +R + L+  L  AK   E E  +   L    
Sbjct: 3514 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL---- 3569

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
             ++ + L++   Q     E + K +SE    + +    +  ++  QA +  + E  ++  
Sbjct: 3570 NEVHDKLSKLSVQ-DYSTEGLWKQQSELRVLQEDILLRKQNVD--QALLNGL-ELLKQTT 3625

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTA 1977
             D     Q +LE  ++RY ++I KL      +  +          T + +   L K    
Sbjct: 3626 GDEVLIIQDKLEAIKARY-KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3684

Query: 1978 MQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA--------SASPKEKY 2029
            +  YE Q++      +     K +++ A   +  L     ++ A        +    EK 
Sbjct: 3685 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3744

Query: 2030 SLVEAKRKKLISPESTVMLLEAQAA 2054
               + +R +L+S   T  + E  AA
Sbjct: 3745 VAEDNERYRLVSDTITQKVEEIDAA 3769



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 187/966 (19%), Positives = 383/966 (39%), Gaps = 146/966 (15%)

Query: 996  AADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A+ + A+  +L  R  +      E L  +E+LK K    E L E+L+   +  ++   + 
Sbjct: 2176 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEV 2235

Query: 1056 KF-------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                     L Q +Q+  +E  + K  L  L  L ++    G  + + L      + E  
Sbjct: 2236 DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL------VLEKT 2289

Query: 1109 EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA-IKEK 1167
              +++   E+ED  + +K       +Q + +  L K+ +       W K  ++K  I + 
Sbjct: 2290 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLK------SWIKETTKKVPIVQP 2343

Query: 1168 EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS--NLRNKYETEINI--------- 1216
             +  E L   L++    + ++  +  +++   N  +S  NL +   T             
Sbjct: 2344 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2403

Query: 1217 ------TKTTIKEISMQKEDDSKNLRNQLDRLSRENRDL----KDEIVRLNDSILQATEQ 1266
                  T T  +E    K   S  ++  +  +S    DL    KD+I  LN  + +   Q
Sbjct: 2404 VLNGEGTATNTEEFWANKGLTS--IKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--Q 2459

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
            + + E +A+ Q       +QK      + +Q                 EA KT  ++NK 
Sbjct: 2460 KAQEESSAMMQW------LQKMNKTATKWQQTPAPTDT----------EAVKTQVEQNKS 2503

Query: 1327 IERLKAEFQEEAKRRWEYENELSKV-RNNYDEEIISLKNQFETEINITKTTIHQLTM--- 1382
             E   AE ++   +  E +++L+++   N D        Q  TEI+     ++QLT+   
Sbjct: 2504 FE---AELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2560

Query: 1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQ 1442
            QK E++S    Q   +  + +    E + + + L   + +   +    QQ +    E + 
Sbjct: 2561 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2620

Query: 1443 RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR--KCL 1500
            RK Q E    Q+T     + +  +   D + + I    +++  + Q  D  T     +C 
Sbjct: 2621 RKPQYE----QLTA--AGQGILSRPGEDPSLRGIV--KEQLAAVTQKWDSLTGQLSDRCD 2672

Query: 1501 EDENARLQRVQYD--LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
              + A ++  QY   L+  +   ++  NKL                VS      +Q +  
Sbjct: 2673 WIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA-----------VSTHPDAMNQQLET 2721

Query: 1559 FQNSLKELQLQKQKVE------EELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI 1612
             Q   +E+Q +K++++      E+L+ L +    +   + +L  +LEG+ +S K+   K 
Sbjct: 2722 AQKMKQEIQQEKKQIKVAQALCEDLSALVK----EEYLKAELSRQLEGILKSFKDVEQKA 2777

Query: 1613 TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQ 1672
             N  Q L+ A      S    +Q        L  K+  Q +   +S++++ L        
Sbjct: 2778 ENHVQHLQSACA----SSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-------- 2825

Query: 1673 ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732
            ES+ + H   + F K +  +S    ++  E E L   T+   K  L L+  L  ++  +D
Sbjct: 2826 ESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--LNTIKTNWD 2880

Query: 1733 DLRRGRSEADSDKNATI---LELRSQLQISNNRTLELQGLINDLQ-----RERENLRQEI 1784
               +   E ++    ++   L+ + Q++       + Q  + +++      E EN   ++
Sbjct: 2881 TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL 2940

Query: 1785 EKFQKQALEASNRIQESKNQCTQ-----------VVQERESLLVKIK-VLEQDKARLQRL 1832
            +  QK+  +    ++   N               V  E +SL+ K+  V EQ  ++   L
Sbjct: 2941 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3000

Query: 1833 EDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIRKIESE 1884
            E+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++ ++ +
Sbjct: 3001 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3060

Query: 1885 REKSER 1890
             + ++R
Sbjct: 3061 VDLAKR 3066



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 222/1228 (18%), Positives = 467/1228 (38%), Gaps = 188/1228 (15%)

Query: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF- 917
            ++  +   W   +KQ+  R   L++ +++   Y++  +    W+    + Q++LE +KF 
Sbjct: 2871 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI---DKCQNNLEEIKFC 2927

Query: 918  ----GDSNTVMRFLNEQKNLHSE---ISGKRDKSEEVQKIAELCANSIKDYELQLASYTS 970
                   N++ +  + QK +      +    + +  +  + E+    + D    L     
Sbjct: 2928 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2987

Query: 971  GLETLLNIPIKRTMIQSPSGVI--LQEAADVHARYIELLTRSGDYYRFLSEML---KSLE 1025
             +   L+   K+  +++ +      QE +    R ++      D +  L       K L 
Sbjct: 2988 MVTEQLH--SKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3045

Query: 1026 DLKLKNTKIEVLEEEL----RLARDANSENCNKNKFLDQNL-------------QKYQAE 1068
             L+ +   ++ L+ ++    RLA+D   E  +     D  L             Q+   +
Sbjct: 3046 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3105

Query: 1069 CSQFKAKLASL--------EELKRQAELD---------GKSAKQNLDKCYGQIKELNEKI 1111
            CS  + KL  +        E   + AE D         G+ A + L K    IK   +K+
Sbjct: 3106 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA-ETLQKQKETIKAFLKKL 3164

Query: 1112 TRLTYEIEDEKRRRKSVEDRFDQQ------KNDYDQLQKARQCEKENLGWQKLESE---- 1161
              L    ++  +  K +    +        K D + L K  QC K     Q  E +    
Sbjct: 3165 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSK--QCNKLLDRAQAREEQVEGT 3222

Query: 1162 -KAIKEKEYEIERLRVLLQEE----------GTRKREYENELAKVRNHYNEEMSNLRNKY 1210
             K ++E   +++   +LLQ+           G        +L   +    EE+  L+ K 
Sbjct: 3223 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3282

Query: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLD----RLSRENRDLKDEIVRLNDSILQATEQ 1266
            +    + +  I+  S  K   ++ L + LD    R    N+ +     +L +++L    +
Sbjct: 3283 QDVNWLGQGLIQ--SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC-GR 3339

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
             + A E+ L       E++  ++    E K V  Q  E     ++ L++   T++   +E
Sbjct: 3340 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL-QRLLDDRKSTVEVIKRE 3398

Query: 1327 IERL--KAEFQEEAK---------RRWEYENELSKVRNNYDEEIISLKNQFE---TEINI 1372
             E++   AE  ++ K          RWE     ++ RN   E I  +  QF      +N 
Sbjct: 3399 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3458

Query: 1373 TKTTIHQLTM----------QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTEN 1422
              TTI +  +          + EE  + ++A  D++   N+ L + +     ++ Q+ + 
Sbjct: 3459 WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV-----SIGQSLKV 3513

Query: 1423 L-RRVEEDIQQQKATGSEV----SQRKQQLEVELRQV----TQMRTEESVRYKQSLDDAA 1473
            L  R ++D+ Q K   S+V     Q K     EL Q      ++  E+ V     L++  
Sbjct: 3514 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3573

Query: 1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATET--------- 1524
              +   + +    + L  +++  R   ED   R Q V   L        +T         
Sbjct: 3574 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3633

Query: 1525 --INKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLK- 1581
              +  +K + +++T+L  D  +  ++     Q   R  ++ +EL     KVE EL   + 
Sbjct: 3634 DKLEAIKARYKDITKLSTDVAKTLEQAL---QLARRLHSTHEELCTWLDKVEVELLSYET 3690

Query: 1582 -----RTASEDSCKRKKLEEELEGMRR---SLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
                   AS+   + K+L++E +  +    SL E +  +  L     +  + K  +ED+ 
Sbjct: 3691 QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN- 3749

Query: 1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693
                               E  RL S+       + Q+ E +  A LR++ F +A + + 
Sbjct: 3750 -------------------ERYRLVSDT------ITQKVEEIDAAILRSQQFDQAADAEL 3784

Query: 1694 RSLNESKIEIERLQS--LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD-KNATIL 1750
              + E++ ++  L    L ++ T   L +++      L + D+     ++      A   
Sbjct: 3785 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSE 3844

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ 1810
            E +  ++   ++ L+    I  +  ER    +  +    Q  E    +     +   ++ 
Sbjct: 3845 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 3904

Query: 1811 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV-KQRLEC---EKQQIQNDLNQ 1866
            +  +  ++ + L Q +   ++L + +   K  ++   +   Q LE    E   IQ     
Sbjct: 3905 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 3964

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR---------KL 1917
              T YS+ +E ++K     +++  +      +I+++   ++RI ER R+         K+
Sbjct: 3965 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKI 4024

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            ++   E ++ +  +  + Q   + L+QR
Sbjct: 4025 KEQISENKN-VSVDMEKLQPLYETLKQR 4051



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 210/1176 (17%), Positives = 463/1176 (39%), Gaps = 157/1176 (13%)

Query: 858  EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            +K+  +  R++ I K        LE+ ++  R     ++  C WL   +    S E+   
Sbjct: 3634 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYET--- 3690

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA-NSIKDYELQLASYTS--GLET 974
                   + L  ++   +++  K  K E     A L + N +    L+L  + +  GLE 
Sbjct: 3691 -------QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3743

Query: 975  LLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKI 1034
            ++    +R  + S +  I Q+  ++ A  +    RS  + +     L  + + + K   +
Sbjct: 3744 MVAEDNERYRLVSDT--ITQKVEEIDAAIL----RSQQFDQAADAELSWITETEKKLMSL 3797

Query: 1035 EVLEEELRLARDANSENCNKNKFLDQNLQKYQAEC-----SQFKAKLASLEELKRQAELD 1089
                 ++RL +D  S      K     + +++        S  K   A  EE K+     
Sbjct: 3798 G----DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ----- 3848

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
              S K+ LDK    + +  + I ++  E   +  R +S+ ++F +   +        Q  
Sbjct: 3849 --SMKKKLDK----VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3902

Query: 1150 KENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
               L    LE E  +++++ E  +LR L+ E      +      ++      E  +++ K
Sbjct: 3903 ISQLPAPALEYE-TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEK 3961

Query: 1210 YETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR 1269
            Y             +  Q ++D K     LD    ++    D+I ++ +S+ +  E+ R+
Sbjct: 3962 Y--------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4013

Query: 1270 AEENALQQKACGSEIMQKKQ-HLEIE----LKQVMQQRSEDNARHKQSLEE--AAKTIQD 1322
                + + +    +I + K   +++E    L + ++QR E+        ++  +AK +QD
Sbjct: 4014 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4073

Query: 1323 KNKEI----ERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH 1378
            K  ++    E +    +E   +  +      K   ++   I+++K+  +   ++    I 
Sbjct: 4074 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4133

Query: 1379 -QLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATG 1437
              +  Q++E     R +ID L  E   +      L     +  + +  V++ I +  +  
Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4191

Query: 1438 SEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD------DAA----KTIQDKNKEIERLK 1487
              +++  +    +L +  Q     +V+Y+  L       D A     ++     ++E +K
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQA----AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4247

Query: 1488 QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547
            Q I++    +     +   ++R+ +  +      TE  +K  VQ+  L  L++ ++ + +
Sbjct: 4248 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP-LMELKLIWDSL-E 4305

Query: 1548 ERTVKDQD--------ITRFQNSLKELQ---------LQKQK--------VEEELNRLKR 1582
            ER +  Q         + +FQ++L EL          L +QK        +E EL +   
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HH 4364

Query: 1583 TASEDSCKRKKLEEELEGMRRSLKEQAI--KITNLTQQLEQASIVKKRSEDDLRQQRDVL 1640
                D    +   E +      L E +   + +NL  +LE  +   +   +   Q++  L
Sbjct: 4365 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4424

Query: 1641 DGHLREKQRTQEELRRLSSEVEALRRQLLQEQ------ESVKQAHLRNEHFQKAIEDKSR 1694
            DG LR+ +    E+  L   +    R LL  +      E+ K+    N H +     +++
Sbjct: 4425 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ--LNVHMEVCAAFEAK 4482

Query: 1695 SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATI---LE 1751
                  +  +  Q L          +++++ NL+ +++ +    +E  +     +   +E
Sbjct: 4483 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4542

Query: 1752 LRSQLQISNNRTLELQGLINDLQR-------------ERENLRQEIEKFQKQALEASNRI 1798
              + LQ   N   + +  +N   R             E +    E+   ++Q +E     
Sbjct: 4543 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4602

Query: 1799 QESK--NQCTQVVQERESLLVKI-----KVLEQDKARLQRLEDELNRAKSTLEAETRVKQ 1851
               K  +Q   VV  + +LL+ +     KV+++   R + L+D   RAK   EA +++ +
Sbjct: 4603 THLKYFSQKQDVVLIK-NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4661

Query: 1852 RLECEKQ------QIQNDLNQWKTQYSRKEEAIRKIESERE---------KSEREKNSLR 1896
             LE  ++      +I ND ++ KTQ ++ +E  + + ++           +S +EK SL 
Sbjct: 4662 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4721

Query: 1897 SEIERLQAEIKRIEER----CRRKLEDSTRETQSQL 1928
             +  +L   +  + ++    C + +E   +  ++ L
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4757



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 186/959 (19%), Positives = 361/959 (37%), Gaps = 164/959 (17%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 3996 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 4056 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4115

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 4116 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4166

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 4167 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4219

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 4220 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4278

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 4279 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4332

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 4333 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4391

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4392 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4448

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4449 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4508

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK-- 1218
            ++ I   + + E +   L E  T+  E  N LA   ++  ++  N   + E  +N+    
Sbjct: 4509 DQDINNLKEKWESVETKLNERKTKLEEALN-LAMEFHNSLQDFINWLTQAEQTLNVASRP 4567

Query: 1219 -----TTIKEISMQK--EDDSKNLRNQLDRLSRENRDL-----KDEIVRLN--------- 1257
                 T + +I   K   ++  + R Q+  L +    L     K ++V +          
Sbjct: 4568 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4627

Query: 1258 -DSILQATEQRRR----AEENALQQKACGSEIM------QKKQHLEIELKQVMQQRSEDN 1306
             + ++Q   +R R    A + A Q     S++M      +K    E+E+     +     
Sbjct: 4628 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4687

Query: 1307 ARHKQSLEE--AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD-------- 1356
            A+HK+  +   A  ++ D      R   E    A    + ++ LS++R+ +D        
Sbjct: 4688 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4747

Query: 1357 -----EEIISLKNQFETEINITKTTIHQLTMQKEED--TSGYRAQIDNLTRENRSLSEEI 1409
                 EE +    QF   +      ++++  Q  ED    G    + NL   +++  +E+
Sbjct: 4748 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4807

Query: 1410 KRLKNTLTQTTENLRRV----EEDIQQQKATGSEVSQR-----------KQQLEVELRQV 1454
             +  +++     + R +     +D    K    E+S R           + +LE  LRQ 
Sbjct: 4808 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4867

Query: 1455 TQMRT------------EESVRYKQSL---DDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
             +  +            E+++R+   L   +DA +T+ D++KE   +K+L +K     K
Sbjct: 4868 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF--MKKLEEKRAELNK 4924



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 193/1127 (17%), Positives = 438/1127 (38%), Gaps = 186/1127 (16%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 4214 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4272

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 4273 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4304

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 4305 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4356

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4416

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4417 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4463

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4464 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4517

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4518 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4576

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4577 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4624

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4625 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4678

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        + 
Sbjct: 4679 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT-----SLA 4721

Query: 1106 ELNEKITRLTYEIED--EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA 1163
            + N K+  +  E+ D  +    KSVE +        ++L++A          Q  ++ +A
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQ--------NKLEEALL-----FSGQFTDALQA 4768

Query: 1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH--YNEEMSNLRNKYETEINITKTTI 1221
            + +  Y +E     L E+     + +  +  + NH  + +E+     K  + +   K + 
Sbjct: 4769 LIDWLYRVE---PQLAEDQPVHGDIDLVMNLIDNHKAFQKEL----GKRTSSVQALKRSA 4821

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
            +E+     DDS  ++ Q+  LS              +++   +  ++   E AL+Q    
Sbjct: 4822 RELIEGSRDDSSWVKVQMQELSTR-----------WETVCALSISKQTRLEAALRQ---- 4866

Query: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
            +E      H  +E     +Q    +       E+A +T+ D++KE  +   E + E  + 
Sbjct: 4867 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRTLIDQHKEFMKKLEEKRAELNKA 4925

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE 1401
                + +  +   + + I ++K+     I I +    ++    ++      + +  L  +
Sbjct: 4926 TTMGDTVLAI--CHPDSITTIKHW----ITIIRARFEEVLAWAKQHQQRLASALAGLIAK 4979

Query: 1402 NRSLSEEIKRLKNTLTQTTENLRRV-EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTE 1460
               L   +  L+   T  T+  + V  ++I++ KA  +E                Q   E
Sbjct: 4980 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE---------------HQTFME 5024

Query: 1461 ESVRYKQSLDDAAKTIQDKNKEIERLKQ---LIDKETNDRKCLEDENARLQRVQYDLQKA 1517
            E  R +  +D   KT + +  +   L+    ++DK    RK     +      Q  ++  
Sbjct: 5025 EMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETK 5084

Query: 1518 NSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL 1577
            N      +N L  + Q++  L ++  R   +   + +++  F N   +  + ++K    +
Sbjct: 5085 N----PRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF--DFDIWRKKYMRWM 5138

Query: 1578 NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
            N  K++   D  +R   +++ +  R+   +  +     T +LE +++
Sbjct: 5139 NH-KKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAV 5184



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4779 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4836

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 4897 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4953

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 4954 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5010

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 5011 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5070

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 5071 SLYPSGSQTQIETKNPRVNLLVSKW 5095



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2822 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2849
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5439 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5466



 Score = 35.4 bits (80), Expect = 0.82
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2825 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2851
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5446 SRPGSRAGSKAGSRASSRRGSDASDFD 5472



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2798 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2841
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5424 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5466


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  609 bits (1571), Expect = e-173
 Identities = 460/1803 (25%), Positives = 884/1803 (49%), Gaps = 168/1803 (9%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 641  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 701  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 761  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 821  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 881  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 941  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1092

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 1093 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1151

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 1152 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1211

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1271

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 1272 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1331

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 1332 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1391

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1392 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1451

Query: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067
            T    Y +F  + LK LE            EEE               K L++  +++  
Sbjct: 1452 TLMTQYIKFAGDSLKRLE------------EEE---------------KSLEEEKKEHVE 1484

Query: 1068 ECSQFKAKLASLEELKRQAELDGKS--AKQNLDKCYGQIKELNEKITRLTYEIED-EKRR 1124
            +  + +  ++++ +  + AE  GK   +KQ +       +E++ K  +L+  ++  +   
Sbjct: 1485 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS-----EEISTKKEQLSEALQTIQLFL 1539

Query: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
             K  +   D+++N+ ++  K  Q E  NL +   ES K ++E +   + ++V  +    R
Sbjct: 1540 AKHGDKMTDEERNELEKQVKTLQ-ESYNLLFS--ESLKQLQESQTSGD-VKVEEKIVAER 1595

Query: 1185 KREYENELAKVRNHYNEEMSNLRNKYET-EINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
            ++EY+ +L  + +   +  + L    E   I      +K+   ++E+  K+++     L+
Sbjct: 1596 QQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA 1655

Query: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS 1303
                    E+V+  ++ L+   ++   E+ AL        I QK    +I+ +Q+     
Sbjct: 1656 --------EVVKNTENFLKENGEKLSQEDKAL--------IEQKLNEAKIKCEQL----- 1694

Query: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN-NYDEEIISL 1362
              N + +QS +E  K +    KE     A  ++  + + + EN L  + N + D E    
Sbjct: 1695 --NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1752

Query: 1363 KNQFETEINIT--KTTIHQLTMQKEEDTSGYRAQID-----NLTRENRSLSEEIKRLKNT 1415
            K++   E N T  +    +  + +E++ +G   + D       T+EN  L+++ +++K  
Sbjct: 1753 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN--LNQQYQKVK-- 1808

Query: 1416 LTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE-SVRYKQSLDDAAK 1474
              Q  + + + +  I   ++    + ++ Q L  E ++  Q   +E  V Y+ +L ++ K
Sbjct: 1809 -AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1867

Query: 1475 TIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ- 1533
             ++  +   E L++     T     L+     L+ ++      N   T+   +    E  
Sbjct: 1868 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1927

Query: 1534 -----ELTRLRIDYERVSQ-ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASED 1587
                 +L  + I   RV +  ++   +D  +   S    ++Q+ K++   +R +   S+ 
Sbjct: 1928 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQR-KLDHATDRFRSLYSKC 1986

Query: 1588 SCKRKKLEEELE----------GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQR 1637
            +     L++ ++          G+   L  QA + T      E  ++  K  +  L + +
Sbjct: 1987 NVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQLEETK 2044

Query: 1638 DVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697
              L G +  +Q   E+L++ +  +   R  LL  +  +++     +      ED S+S+N
Sbjct: 2045 -ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT---LDDIVGRYEDLSKSVN 2100

Query: 1698 ESKIEIERLQ-SLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756
            E     E+LQ +LT +L+ +   L+E L  +      L   + +     N+T L    Q 
Sbjct: 2101 ERN---EKLQITLTRSLSVQD-GLDEMLDWMGNVESSL---KEQGQVPLNSTAL----QD 2149

Query: 1757 QISNNRTLE--LQGLINDLQRERENLRQEIE--------KFQKQALEASNRIQESKNQCT 1806
             IS N  LE  + G  + +    E +++ +E          Q +  + S R  E+ ++  
Sbjct: 2150 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2209

Query: 1807 QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ 1866
            + + + E L  K+++ E    +LQ   +   +A + ++   +    L    Q+  ++  +
Sbjct: 2210 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2269

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K         +++I S    S  +K  +  +   L  + K +E+  + K E  T   Q 
Sbjct: 2270 HKKHLEVLHSLLKEISSHGLPS--DKALVLEKTNNLSKKFKEMEDTIKEKKEAVT-SCQE 2326

Query: 1927 QLE 1929
            QL+
Sbjct: 2327 QLD 2329



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 231/1243 (18%), Positives = 489/1243 (39%), Gaps = 199/1243 (16%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 3305 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 3356 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3414

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3415 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3467

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL------------ 1058
             ++   + + L + E +    T+   LEE++   +    +  N NK L            
Sbjct: 3468 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524

Query: 1059 -----DQNLQKYQAECSQ-----FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                 D+++ + + + SQ      + K  S  EL +QA  + K   ++  +    + E++
Sbjct: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3584

Query: 1109 EKITRLT---YEIE----DEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL--- 1158
            +K+++L+   Y  E     +   R   ED   +++N    L    +  K+  G + L   
Sbjct: 3585 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3644

Query: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK 1218
            +  +AIK +  +I +    L  +  +  E   +LA+  +  +EE+    +K E E+   +
Sbjct: 3645 DKLEAIKARYKDITK----LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3700

Query: 1219 TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR-------AE 1271
            T +  +  ++   ++    +L + ++ N+ L D +  ++ ++L+    R R       AE
Sbjct: 3701 TQV--LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3758

Query: 1272 ENALQQKACGSEIMQKKQHLEIEL--KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
            +N  + +     I QK + ++  +   Q   Q ++         E+   ++ D   E ++
Sbjct: 3759 DNE-RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3817

Query: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
              A+ Q               V+  +  EI+  K+  +   ++ K+    +T   EE+  
Sbjct: 3818 TSAQLQ---------------VQKTFTMEILRHKDIID---DLVKSGHKIMTACSEEEKQ 3859

Query: 1390 GYRAQIDNLTRENRSLSE-------EIKRLKNTLTQTTEN-------LRRVEEDIQQQKA 1435
              + ++D + +   ++ +       +++R ++ + Q  E        L   +  I Q  A
Sbjct: 3860 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3919

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT--------------IQDKNK 1481
               E    +QQ E E RQ+ ++  E    +K  +D   KT              IQ+K  
Sbjct: 3920 PALEYETLRQQQE-EHRQLRELIAE----HKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3974

Query: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQY--DLQKANSSATETINKLKVQEQELTRLR 1539
              + L   I ++   R    DE A  Q  Q+   + +   S    + +L+        + 
Sbjct: 3975 AADTLYSQIKEDVKKRAVALDE-AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVE 4033

Query: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCK--RKKLEEE 1597
               E++S+ + V   D+ + Q   + L   KQ+ EE + R   T  + S K  + KL++ 
Sbjct: 4034 KIKEQISENKNV-SVDMEKLQPLYETL---KQRGEEMIARSGGTDKDISAKAVQDKLDQM 4089

Query: 1598 L---EGMRRSLKEQAIKITNLTQQLEQ-------ASIVKKRSEDDLRQQRDV-LDGHLRE 1646
            +   E +   ++E+  K+ ++ +  E+         +  K ++D +R   D  +D  + +
Sbjct: 4090 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4149

Query: 1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL 1706
            +Q  QE    +  E++ L+ +L    + V   +L +E      E     + +S  E+   
Sbjct: 4150 QQ--QEAAETIREEIDGLQEEL----DIV--INLGSELIAACGEPDKPIVKKSIDELNSA 4201

Query: 1707 QSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766
                    K+ +   EE     ++Y D               +  +   + I+  +   +
Sbjct: 4202 WDSLNKAWKDRIDKLEEAMQAAVQYQD--------------GLQAVFDWVDIAGGKLASM 4247

Query: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
              +  DL+  ++ + +E+++F+ +A +    ++   +Q          LL+K    E DK
Sbjct: 4248 SPIGTDLETVKQQI-EELKQFKSEAYQQQIEMERLNHQA--------ELLLKKVTEESDK 4298

Query: 1827 ARLQRLEDELNRAKSTLEAETRVKQ-RLE------CEKQQIQNDLNQWKTQYSRKEEAIR 1879
              +Q    EL     +LE     +Q +LE       + Q   ++L  W T         +
Sbjct: 4299 HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQK 4358

Query: 1880 KIESEREKSERE---KNSLRSEIERLQAEIKRIEERCRRKLEDSTRE----TQSQLETER 1932
             +  + +  E E    + L++++   Q+ ++ + +     +E S  E     Q++LE   
Sbjct: 4359 PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLN 4418

Query: 1933 SRYQREIDKLRQRPY----------GSHRETQTECEWTVDTSK 1965
             R+Q  ++K  QR            G H E +   +W  DT +
Sbjct: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 234/1345 (17%), Positives = 513/1345 (38%), Gaps = 173/1345 (12%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2619

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE   A+    L      P  R +++     
Sbjct: 2620 -------------QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2666

Query: 992  ILQ-------EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK-------NTKIEVL 1037
            + Q       + +D      + + +S  Y   L  +   L DL  K       +T  + +
Sbjct: 2667 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2726

Query: 1038 EEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLAS---LEELKRQAELDGKSAK 1094
             ++L  A+    E   + K     ++  QA C    A +       EL RQ E   KS K
Sbjct: 2727 NQQLETAQKMKQEIQQEKK----QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2782

Query: 1095 QNLDKCYGQIKELN---------EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA 1145
                K    ++ L          ++++R      D K+  ++       + +  + L K 
Sbjct: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2842

Query: 1146 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH---YNEE 1202
             +   + L  Q    EK I E E       +LL+ +G+ K   + +L  ++ +   +N++
Sbjct: 2843 HKDFSKTLTAQSHMYEKTIAEGE------NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2896

Query: 1203 MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKD--EIVRLNDSI 1260
            +    NK +  +        E +++ ++  + L   +D+      ++K   +     +SI
Sbjct: 2897 VKERENKLKESL--------EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI 2948

Query: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
             +    ++  +++    +   +         EI+ + V    +++N    Q ++   + +
Sbjct: 2949 AKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV----TDENKSLIQKVDMVTEQL 3004

Query: 1321 QDKNKEIERLKAEFQE------EAKRRWEYENELSKVRNNYDEEIISLK--NQFETEINI 1372
              K   +E +  +F+E      E+KR+ +   E   + ++   +  S K     +T+   
Sbjct: 3005 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3064

Query: 1373 TKTTIHQLTMQK------------EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTT 1420
             +   HQ+ + K             + TS    Q++ + +E+ +LS+++    + L    
Sbjct: 3065 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3124

Query: 1421 ENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKN 1480
            + +   +  I+       E+  +  + + EL  +  +  +     KQ      +TI+   
Sbjct: 3125 QGIGHFQNTIR-------EMFSQFAEFDDELDSMAPVGRDAETLQKQK-----ETIKAFL 3172

Query: 1481 KEIERLKQLIDKETNDRKCL---EDENARLQRVQYDLQKANSSATETINKLKVQEQE--- 1534
            K++E L    D      K +   E+ +  L  ++ DL+  +    + +++ + +E++   
Sbjct: 3173 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3232

Query: 1535 -LTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK 1593
             + RL   Y ++ +E ++  Q     + S   + ++ + + ++LN  K    E+    + 
Sbjct: 3233 TIKRLEEFYSKL-KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 3291

Query: 1594 LEEELEGMRRSLKEQAIKITN---LTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRT 1650
             ++++  + + L + A K T+   L   L+  +   K     + Q+   L   L    R 
Sbjct: 3292 KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRF 3351

Query: 1651 QEELRRLSS------EVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIE 1704
            Q+ L  L S      E+ A ++    E + VK      +  Q+ ++D+  ++   K E E
Sbjct: 3352 QDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE 3411

Query: 1705 RLQSLTENLTK--------------EHLMLEEELRNLRLEYDDLRRGRSEADSDKNATIL 1750
            ++ +  E   K              E L+ + E RN +LE      G S      + T+ 
Sbjct: 3412 KIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLE------GISVVAQQFHETLE 3465

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE--SKNQCTQV 1808
             L   L     R +  + +     +  E + Q  +  +   +  +  + +  S  Q  +V
Sbjct: 3466 PLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH-KALEDDIINHNKHLHQAVSIGQSLKV 3524

Query: 1809 VQERE-----------SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEK 1857
            +  RE           S +  I++ E+  +R + L+  L  AK   E E  +   L    
Sbjct: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL---- 3580

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
             ++ + L++   Q     E + K +SE    + +    +  ++  QA +  + E  ++  
Sbjct: 3581 NEVHDKLSKLSVQ-DYSTEGLWKQQSELRVLQEDILLRKQNVD--QALLNGL-ELLKQTT 3636

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTA 1977
             D     Q +LE  ++RY ++I KL      +  +          T + +   L K    
Sbjct: 3637 GDEVLIIQDKLEAIKARY-KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695

Query: 1978 MQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA--------SASPKEKY 2029
            +  YE Q++      +     K +++ A   +  L     ++ A        +    EK 
Sbjct: 3696 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3755

Query: 2030 SLVEAKRKKLISPESTVMLLEAQAA 2054
               + +R +L+S   T  + E  AA
Sbjct: 3756 VAEDNERYRLVSDTITQKVEEIDAA 3780



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 187/966 (19%), Positives = 383/966 (39%), Gaps = 146/966 (15%)

Query: 996  AADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A+ + A+  +L  R  +      E L  +E+LK K    E L E+L+   +  ++   + 
Sbjct: 2187 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEV 2246

Query: 1056 KF-------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                     L Q +Q+  +E  + K  L  L  L ++    G  + + L      + E  
Sbjct: 2247 DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL------VLEKT 2300

Query: 1109 EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA-IKEK 1167
              +++   E+ED  + +K       +Q + +  L K+ +       W K  ++K  I + 
Sbjct: 2301 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLK------SWIKETTKKVPIVQP 2354

Query: 1168 EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS--NLRNKYETEINI--------- 1216
             +  E L   L++    + ++  +  +++   N  +S  NL +   T             
Sbjct: 2355 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2414

Query: 1217 ------TKTTIKEISMQKEDDSKNLRNQLDRLSRENRDL----KDEIVRLNDSILQATEQ 1266
                  T T  +E    K   S  ++  +  +S    DL    KD+I  LN  + +   Q
Sbjct: 2415 VLNGEGTATNTEEFWANKGLTS--IKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--Q 2470

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
            + + E +A+ Q       +QK      + +Q                 EA KT  ++NK 
Sbjct: 2471 KAQEESSAMMQW------LQKMNKTATKWQQTPAPTDT----------EAVKTQVEQNKS 2514

Query: 1327 IERLKAEFQEEAKRRWEYENELSKV-RNNYDEEIISLKNQFETEINITKTTIHQLTM--- 1382
             E   AE ++   +  E +++L+++   N D        Q  TEI+     ++QLT+   
Sbjct: 2515 FE---AELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2571

Query: 1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQ 1442
            QK E++S    Q   +  + +    E + + + L   + +   +    QQ +    E + 
Sbjct: 2572 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2631

Query: 1443 RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR--KCL 1500
            RK Q E    Q+T     + +  +   D + + I    +++  + Q  D  T     +C 
Sbjct: 2632 RKPQYE----QLTA--AGQGILSRPGEDPSLRGIV--KEQLAAVTQKWDSLTGQLSDRCD 2683

Query: 1501 EDENARLQRVQYD--LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
              + A ++  QY   L+  +   ++  NKL                VS      +Q +  
Sbjct: 2684 WIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA-----------VSTHPDAMNQQLET 2732

Query: 1559 FQNSLKELQLQKQKVE------EELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI 1612
             Q   +E+Q +K++++      E+L+ L +    +   + +L  +LEG+ +S K+   K 
Sbjct: 2733 AQKMKQEIQQEKKQIKVAQALCEDLSALVK----EEYLKAELSRQLEGILKSFKDVEQKA 2788

Query: 1613 TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQ 1672
             N  Q L+ A      S    +Q        L  K+  Q +   +S++++ L        
Sbjct: 2789 ENHVQHLQSACA----SSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-------- 2836

Query: 1673 ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732
            ES+ + H   + F K +  +S    ++  E E L   T+   K  L L+  L  ++  +D
Sbjct: 2837 ESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--LNTIKTNWD 2891

Query: 1733 DLRRGRSEADSDKNATI---LELRSQLQISNNRTLELQGLINDLQ-----RERENLRQEI 1784
               +   E ++    ++   L+ + Q++       + Q  + +++      E EN   ++
Sbjct: 2892 TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL 2951

Query: 1785 EKFQKQALEASNRIQESKNQCTQ-----------VVQERESLLVKIK-VLEQDKARLQRL 1832
            +  QK+  +    ++   N               V  E +SL+ K+  V EQ  ++   L
Sbjct: 2952 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3011

Query: 1833 EDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIRKIESE 1884
            E+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++ ++ +
Sbjct: 3012 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071

Query: 1885 REKSER 1890
             + ++R
Sbjct: 3072 VDLAKR 3077



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 222/1228 (18%), Positives = 467/1228 (38%), Gaps = 188/1228 (15%)

Query: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF- 917
            ++  +   W   +KQ+  R   L++ +++   Y++  +    W+    + Q++LE +KF 
Sbjct: 2882 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI---DKCQNNLEEIKFC 2938

Query: 918  ----GDSNTVMRFLNEQKNLHSE---ISGKRDKSEEVQKIAELCANSIKDYELQLASYTS 970
                   N++ +  + QK +      +    + +  +  + E+    + D    L     
Sbjct: 2939 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2998

Query: 971  GLETLLNIPIKRTMIQSPSGVI--LQEAADVHARYIELLTRSGDYYRFLSEML---KSLE 1025
             +   L+   K+  +++ +      QE +    R ++      D +  L       K L 
Sbjct: 2999 MVTEQLH--SKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3056

Query: 1026 DLKLKNTKIEVLEEEL----RLARDANSENCNKNKFLDQNL-------------QKYQAE 1068
             L+ +   ++ L+ ++    RLA+D   E  +     D  L             Q+   +
Sbjct: 3057 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3116

Query: 1069 CSQFKAKLASL--------EELKRQAELD---------GKSAKQNLDKCYGQIKELNEKI 1111
            CS  + KL  +        E   + AE D         G+ A + L K    IK   +K+
Sbjct: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA-ETLQKQKETIKAFLKKL 3175

Query: 1112 TRLTYEIEDEKRRRKSVEDRFDQQ------KNDYDQLQKARQCEKENLGWQKLESE---- 1161
              L    ++  +  K +    +        K D + L K  QC K     Q  E +    
Sbjct: 3176 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSK--QCNKLLDRAQAREEQVEGT 3233

Query: 1162 -KAIKEKEYEIERLRVLLQEE----------GTRKREYENELAKVRNHYNEEMSNLRNKY 1210
             K ++E   +++   +LLQ+           G        +L   +    EE+  L+ K 
Sbjct: 3234 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3293

Query: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLD----RLSRENRDLKDEIVRLNDSILQATEQ 1266
            +    + +  I+  S  K   ++ L + LD    R    N+ +     +L +++L    +
Sbjct: 3294 QDVNWLGQGLIQ--SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC-GR 3350

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
             + A E+ L       E++  ++    E K V  Q  E     ++ L++   T++   +E
Sbjct: 3351 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL-QRLLDDRKSTVEVIKRE 3409

Query: 1327 IERL--KAEFQEEAK---------RRWEYENELSKVRNNYDEEIISLKNQFE---TEINI 1372
             E++   AE  ++ K          RWE     ++ RN   E I  +  QF      +N 
Sbjct: 3410 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3469

Query: 1373 TKTTIHQLTM----------QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTEN 1422
              TTI +  +          + EE  + ++A  D++   N+ L + +     ++ Q+ + 
Sbjct: 3470 WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV-----SIGQSLKV 3524

Query: 1423 L-RRVEEDIQQQKATGSEV----SQRKQQLEVELRQV----TQMRTEESVRYKQSLDDAA 1473
            L  R ++D+ Q K   S+V     Q K     EL Q      ++  E+ V     L++  
Sbjct: 3525 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3584

Query: 1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATET--------- 1524
              +   + +    + L  +++  R   ED   R Q V   L        +T         
Sbjct: 3585 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3644

Query: 1525 --INKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLK- 1581
              +  +K + +++T+L  D  +  ++     Q   R  ++ +EL     KVE EL   + 
Sbjct: 3645 DKLEAIKARYKDITKLSTDVAKTLEQAL---QLARRLHSTHEELCTWLDKVEVELLSYET 3701

Query: 1582 -----RTASEDSCKRKKLEEELEGMRR---SLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
                   AS+   + K+L++E +  +    SL E +  +  L     +  + K  +ED+ 
Sbjct: 3702 QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN- 3760

Query: 1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693
                               E  RL S+       + Q+ E +  A LR++ F +A + + 
Sbjct: 3761 -------------------ERYRLVSDT------ITQKVEEIDAAILRSQQFDQAADAEL 3795

Query: 1694 RSLNESKIEIERLQS--LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD-KNATIL 1750
              + E++ ++  L    L ++ T   L +++      L + D+     ++      A   
Sbjct: 3796 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSE 3855

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ 1810
            E +  ++   ++ L+    I  +  ER    +  +    Q  E    +     +   ++ 
Sbjct: 3856 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 3915

Query: 1811 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV-KQRLEC---EKQQIQNDLNQ 1866
            +  +  ++ + L Q +   ++L + +   K  ++   +   Q LE    E   IQ     
Sbjct: 3916 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 3975

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR---------KL 1917
              T YS+ +E ++K     +++  +      +I+++   ++RI ER R+         K+
Sbjct: 3976 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKI 4035

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            ++   E ++ +  +  + Q   + L+QR
Sbjct: 4036 KEQISENKN-VSVDMEKLQPLYETLKQR 4062



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 210/1176 (17%), Positives = 463/1176 (39%), Gaps = 157/1176 (13%)

Query: 858  EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            +K+  +  R++ I K        LE+ ++  R     ++  C WL   +    S E+   
Sbjct: 3645 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYET--- 3701

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA-NSIKDYELQLASYTS--GLET 974
                   + L  ++   +++  K  K E     A L + N +    L+L  + +  GLE 
Sbjct: 3702 -------QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3754

Query: 975  LLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKI 1034
            ++    +R  + S +  I Q+  ++ A  +    RS  + +     L  + + + K   +
Sbjct: 3755 MVAEDNERYRLVSDT--ITQKVEEIDAAIL----RSQQFDQAADAELSWITETEKKLMSL 3808

Query: 1035 EVLEEELRLARDANSENCNKNKFLDQNLQKYQAEC-----SQFKAKLASLEELKRQAELD 1089
                 ++RL +D  S      K     + +++        S  K   A  EE K+     
Sbjct: 3809 G----DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ----- 3859

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
              S K+ LDK    + +  + I ++  E   +  R +S+ ++F +   +        Q  
Sbjct: 3860 --SMKKKLDK----VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3913

Query: 1150 KENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
               L    LE E  +++++ E  +LR L+ E      +      ++      E  +++ K
Sbjct: 3914 ISQLPAPALEYE-TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEK 3972

Query: 1210 YETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR 1269
            Y             +  Q ++D K     LD    ++    D+I ++ +S+ +  E+ R+
Sbjct: 3973 Y--------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024

Query: 1270 AEENALQQKACGSEIMQKKQ-HLEIE----LKQVMQQRSEDNARHKQSLEE--AAKTIQD 1322
                + + +    +I + K   +++E    L + ++QR E+        ++  +AK +QD
Sbjct: 4025 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4084

Query: 1323 KNKEI----ERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH 1378
            K  ++    E +    +E   +  +      K   ++   I+++K+  +   ++    I 
Sbjct: 4085 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144

Query: 1379 -QLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATG 1437
              +  Q++E     R +ID L  E   +      L     +  + +  V++ I +  +  
Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4202

Query: 1438 SEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD------DAA----KTIQDKNKEIERLK 1487
              +++  +    +L +  Q     +V+Y+  L       D A     ++     ++E +K
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQA----AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4258

Query: 1488 QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547
            Q I++    +     +   ++R+ +  +      TE  +K  VQ+  L  L++ ++ + +
Sbjct: 4259 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP-LMELKLIWDSL-E 4316

Query: 1548 ERTVKDQD--------ITRFQNSLKELQ---------LQKQK--------VEEELNRLKR 1582
            ER +  Q         + +FQ++L EL          L +QK        +E EL +   
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HH 4375

Query: 1583 TASEDSCKRKKLEEELEGMRRSLKEQAI--KITNLTQQLEQASIVKKRSEDDLRQQRDVL 1640
                D    +   E +      L E +   + +NL  +LE  +   +   +   Q++  L
Sbjct: 4376 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4435

Query: 1641 DGHLREKQRTQEELRRLSSEVEALRRQLLQEQ------ESVKQAHLRNEHFQKAIEDKSR 1694
            DG LR+ +    E+  L   +    R LL  +      E+ K+    N H +     +++
Sbjct: 4436 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ--LNVHMEVCAAFEAK 4493

Query: 1695 SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATI---LE 1751
                  +  +  Q L          +++++ NL+ +++ +    +E  +     +   +E
Sbjct: 4494 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4553

Query: 1752 LRSQLQISNNRTLELQGLINDLQR-------------ERENLRQEIEKFQKQALEASNRI 1798
              + LQ   N   + +  +N   R             E +    E+   ++Q +E     
Sbjct: 4554 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4613

Query: 1799 QESK--NQCTQVVQERESLLVKI-----KVLEQDKARLQRLEDELNRAKSTLEAETRVKQ 1851
               K  +Q   VV  + +LL+ +     KV+++   R + L+D   RAK   EA +++ +
Sbjct: 4614 THLKYFSQKQDVVLIK-NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4672

Query: 1852 RLECEKQ------QIQNDLNQWKTQYSRKEEAIRKIESERE---------KSEREKNSLR 1896
             LE  ++      +I ND ++ KTQ ++ +E  + + ++           +S +EK SL 
Sbjct: 4673 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4732

Query: 1897 SEIERLQAEIKRIEER----CRRKLEDSTRETQSQL 1928
             +  +L   +  + ++    C + +E   +  ++ L
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 186/959 (19%), Positives = 361/959 (37%), Gaps = 164/959 (17%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 4127 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4177

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 4178 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4230

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 4231 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4289

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 4290 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4343

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 4344 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4402

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4403 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4459

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4460 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4519

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK-- 1218
            ++ I   + + E +   L E  T+  E  N LA   ++  ++  N   + E  +N+    
Sbjct: 4520 DQDINNLKEKWESVETKLNERKTKLEEALN-LAMEFHNSLQDFINWLTQAEQTLNVASRP 4578

Query: 1219 -----TTIKEISMQK--EDDSKNLRNQLDRLSRENRDL-----KDEIVRLN--------- 1257
                 T + +I   K   ++  + R Q+  L +    L     K ++V +          
Sbjct: 4579 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4638

Query: 1258 -DSILQATEQRRR----AEENALQQKACGSEIM------QKKQHLEIELKQVMQQRSEDN 1306
             + ++Q   +R R    A + A Q     S++M      +K    E+E+     +     
Sbjct: 4639 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4698

Query: 1307 ARHKQSLEE--AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD-------- 1356
            A+HK+  +   A  ++ D      R   E    A    + ++ LS++R+ +D        
Sbjct: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758

Query: 1357 -----EEIISLKNQFETEINITKTTIHQLTMQKEED--TSGYRAQIDNLTRENRSLSEEI 1409
                 EE +    QF   +      ++++  Q  ED    G    + NL   +++  +E+
Sbjct: 4759 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4818

Query: 1410 KRLKNTLTQTTENLRRV----EEDIQQQKATGSEVSQR-----------KQQLEVELRQV 1454
             +  +++     + R +     +D    K    E+S R           + +LE  LRQ 
Sbjct: 4819 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4878

Query: 1455 TQMRT------------EESVRYKQSL---DDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
             +  +            E+++R+   L   +DA +T+ D++KE   +K+L +K     K
Sbjct: 4879 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF--MKKLEEKRAELNK 4935



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 193/1127 (17%), Positives = 438/1127 (38%), Gaps = 186/1127 (16%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 4225 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4283

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 4284 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4315

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 4316 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4367

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4428 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4528

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4529 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4587

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4588 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4635

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4689

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        + 
Sbjct: 4690 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT-----SLA 4732

Query: 1106 ELNEKITRLTYEIED--EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA 1163
            + N K+  +  E+ D  +    KSVE +        ++L++A          Q  ++ +A
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQ--------NKLEEALL-----FSGQFTDALQA 4779

Query: 1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH--YNEEMSNLRNKYETEINITKTTI 1221
            + +  Y +E     L E+     + +  +  + NH  + +E+     K  + +   K + 
Sbjct: 4780 LIDWLYRVE---PQLAEDQPVHGDIDLVMNLIDNHKAFQKEL----GKRTSSVQALKRSA 4832

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
            +E+     DDS  ++ Q+  LS              +++   +  ++   E AL+Q    
Sbjct: 4833 RELIEGSRDDSSWVKVQMQELSTR-----------WETVCALSISKQTRLEAALRQ---- 4877

Query: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
            +E      H  +E     +Q    +       E+A +T+ D++KE  +   E + E  + 
Sbjct: 4878 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRTLIDQHKEFMKKLEEKRAELNKA 4936

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE 1401
                + +  +   + + I ++K+     I I +    ++    ++      + +  L  +
Sbjct: 4937 TTMGDTVLAI--CHPDSITTIKHW----ITIIRARFEEVLAWAKQHQQRLASALAGLIAK 4990

Query: 1402 NRSLSEEIKRLKNTLTQTTENLRRV-EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTE 1460
               L   +  L+   T  T+  + V  ++I++ KA  +E                Q   E
Sbjct: 4991 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE---------------HQTFME 5035

Query: 1461 ESVRYKQSLDDAAKTIQDKNKEIERLKQ---LIDKETNDRKCLEDENARLQRVQYDLQKA 1517
            E  R +  +D   KT + +  +   L+    ++DK    RK     +      Q  ++  
Sbjct: 5036 EMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETK 5095

Query: 1518 NSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL 1577
            N      +N L  + Q++  L ++  R   +   + +++  F N   +  + ++K    +
Sbjct: 5096 N----PRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF--DFDIWRKKYMRWM 5149

Query: 1578 NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
            N  K++   D  +R   +++ +  R+   +  +     T +LE +++
Sbjct: 5150 NH-KKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAV 5195



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4790 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 4908 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 4965 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5021

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 5022 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5081

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 5082 SLYPSGSQTQIETKNPRVNLLVSKW 5106



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2822 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2849
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5450 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5477



 Score = 35.4 bits (80), Expect = 0.82
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2825 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2851
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5457 SRPGSRAGSKAGSRASSRRGSDASDFD 5483



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2798 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2841
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5435 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5477


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  609 bits (1571), Expect = e-173
 Identities = 460/1803 (25%), Positives = 884/1803 (49%), Gaps = 168/1803 (9%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 779  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 838

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 839  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 899  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 958

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 959  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 1018

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 1019 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 1078

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 1079 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1138

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 1139 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1198

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 1199 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1230

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 1231 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1289

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 1290 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1349

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 1350 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1409

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 1410 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1469

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 1470 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1529

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1530 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1589

Query: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067
            T    Y +F  + LK LE            EEE               K L++  +++  
Sbjct: 1590 TLMTQYIKFAGDSLKRLE------------EEE---------------KSLEEEKKEHVE 1622

Query: 1068 ECSQFKAKLASLEELKRQAELDGKS--AKQNLDKCYGQIKELNEKITRLTYEIED-EKRR 1124
            +  + +  ++++ +  + AE  GK   +KQ +       +E++ K  +L+  ++  +   
Sbjct: 1623 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS-----EEISTKKEQLSEALQTIQLFL 1677

Query: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
             K  +   D+++N+ ++  K  Q E  NL +   ES K ++E +   + ++V  +    R
Sbjct: 1678 AKHGDKMTDEERNELEKQVKTLQ-ESYNLLFS--ESLKQLQESQTSGD-VKVEEKIVAER 1733

Query: 1185 KREYENELAKVRNHYNEEMSNLRNKYET-EINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
            ++EY+ +L  + +   +  + L    E   I      +K+   ++E+  K+++     L+
Sbjct: 1734 QQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA 1793

Query: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS 1303
                    E+V+  ++ L+   ++   E+ AL        I QK    +I+ +Q+     
Sbjct: 1794 --------EVVKNTENFLKENGEKLSQEDKAL--------IEQKLNEAKIKCEQL----- 1832

Query: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN-NYDEEIISL 1362
              N + +QS +E  K +    KE     A  ++  + + + EN L  + N + D E    
Sbjct: 1833 --NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1890

Query: 1363 KNQFETEINIT--KTTIHQLTMQKEEDTSGYRAQID-----NLTRENRSLSEEIKRLKNT 1415
            K++   E N T  +    +  + +E++ +G   + D       T+EN  L+++ +++K  
Sbjct: 1891 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN--LNQQYQKVK-- 1946

Query: 1416 LTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE-SVRYKQSLDDAAK 1474
              Q  + + + +  I   ++    + ++ Q L  E ++  Q   +E  V Y+ +L ++ K
Sbjct: 1947 -AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 2005

Query: 1475 TIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ- 1533
             ++  +   E L++     T     L+     L+ ++      N   T+   +    E  
Sbjct: 2006 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 2065

Query: 1534 -----ELTRLRIDYERVSQ-ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASED 1587
                 +L  + I   RV +  ++   +D  +   S    ++Q+ K++   +R +   S+ 
Sbjct: 2066 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQR-KLDHATDRFRSLYSKC 2124

Query: 1588 SCKRKKLEEELE----------GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQR 1637
            +     L++ ++          G+   L  QA + T      E  ++  K  +  L + +
Sbjct: 2125 NVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQLEETK 2182

Query: 1638 DVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697
              L G +  +Q   E+L++ +  +   R  LL  +  +++     +      ED S+S+N
Sbjct: 2183 -ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT---LDDIVGRYEDLSKSVN 2238

Query: 1698 ESKIEIERLQ-SLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756
            E     E+LQ +LT +L+ +   L+E L  +      L   + +     N+T L    Q 
Sbjct: 2239 ERN---EKLQITLTRSLSVQD-GLDEMLDWMGNVESSL---KEQGQVPLNSTAL----QD 2287

Query: 1757 QISNNRTLE--LQGLINDLQRERENLRQEIE--------KFQKQALEASNRIQESKNQCT 1806
             IS N  LE  + G  + +    E +++ +E          Q +  + S R  E+ ++  
Sbjct: 2288 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2347

Query: 1807 QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ 1866
            + + + E L  K+++ E    +LQ   +   +A + ++   +    L    Q+  ++  +
Sbjct: 2348 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2407

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K         +++I S    S  +K  +  +   L  + K +E+  + K E  T   Q 
Sbjct: 2408 HKKHLEVLHSLLKEISSHGLPS--DKALVLEKTNNLSKKFKEMEDTIKEKKEAVT-SCQE 2464

Query: 1927 QLE 1929
            QL+
Sbjct: 2465 QLD 2467



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 231/1243 (18%), Positives = 489/1243 (39%), Gaps = 199/1243 (16%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 3443 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3493

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 3494 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3552

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3553 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3605

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL------------ 1058
             ++   + + L + E +    T+   LEE++   +    +  N NK L            
Sbjct: 3606 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3662

Query: 1059 -----DQNLQKYQAECSQ-----FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                 D+++ + + + SQ      + K  S  EL +QA  + K   ++  +    + E++
Sbjct: 3663 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3722

Query: 1109 EKITRLT---YEIE----DEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL--- 1158
            +K+++L+   Y  E     +   R   ED   +++N    L    +  K+  G + L   
Sbjct: 3723 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3782

Query: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK 1218
            +  +AIK +  +I +    L  +  +  E   +LA+  +  +EE+    +K E E+   +
Sbjct: 3783 DKLEAIKARYKDITK----LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3838

Query: 1219 TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR-------AE 1271
            T +  +  ++   ++    +L + ++ N+ L D +  ++ ++L+    R R       AE
Sbjct: 3839 TQV--LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3896

Query: 1272 ENALQQKACGSEIMQKKQHLEIEL--KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
            +N  + +     I QK + ++  +   Q   Q ++         E+   ++ D   E ++
Sbjct: 3897 DNE-RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3955

Query: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
              A+ Q               V+  +  EI+  K+  +   ++ K+    +T   EE+  
Sbjct: 3956 TSAQLQ---------------VQKTFTMEILRHKDIID---DLVKSGHKIMTACSEEEKQ 3997

Query: 1390 GYRAQIDNLTRENRSLSE-------EIKRLKNTLTQTTEN-------LRRVEEDIQQQKA 1435
              + ++D + +   ++ +       +++R ++ + Q  E        L   +  I Q  A
Sbjct: 3998 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 4057

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT--------------IQDKNK 1481
               E    +QQ E E RQ+ ++  E    +K  +D   KT              IQ+K  
Sbjct: 4058 PALEYETLRQQQE-EHRQLRELIAE----HKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 4112

Query: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQY--DLQKANSSATETINKLKVQEQELTRLR 1539
              + L   I ++   R    DE A  Q  Q+   + +   S    + +L+        + 
Sbjct: 4113 AADTLYSQIKEDVKKRAVALDE-AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVE 4171

Query: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCK--RKKLEEE 1597
               E++S+ + V   D+ + Q   + L   KQ+ EE + R   T  + S K  + KL++ 
Sbjct: 4172 KIKEQISENKNV-SVDMEKLQPLYETL---KQRGEEMIARSGGTDKDISAKAVQDKLDQM 4227

Query: 1598 L---EGMRRSLKEQAIKITNLTQQLEQ-------ASIVKKRSEDDLRQQRDV-LDGHLRE 1646
            +   E +   ++E+  K+ ++ +  E+         +  K ++D +R   D  +D  + +
Sbjct: 4228 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4287

Query: 1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL 1706
            +Q  QE    +  E++ L+ +L    + V   +L +E      E     + +S  E+   
Sbjct: 4288 QQ--QEAAETIREEIDGLQEEL----DIV--INLGSELIAACGEPDKPIVKKSIDELNSA 4339

Query: 1707 QSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766
                    K+ +   EE     ++Y D               +  +   + I+  +   +
Sbjct: 4340 WDSLNKAWKDRIDKLEEAMQAAVQYQD--------------GLQAVFDWVDIAGGKLASM 4385

Query: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
              +  DL+  ++ + +E+++F+ +A +    ++   +Q          LL+K    E DK
Sbjct: 4386 SPIGTDLETVKQQI-EELKQFKSEAYQQQIEMERLNHQA--------ELLLKKVTEESDK 4436

Query: 1827 ARLQRLEDELNRAKSTLEAETRVKQ-RLE------CEKQQIQNDLNQWKTQYSRKEEAIR 1879
              +Q    EL     +LE     +Q +LE       + Q   ++L  W T         +
Sbjct: 4437 HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQK 4496

Query: 1880 KIESEREKSERE---KNSLRSEIERLQAEIKRIEERCRRKLEDSTRE----TQSQLETER 1932
             +  + +  E E    + L++++   Q+ ++ + +     +E S  E     Q++LE   
Sbjct: 4497 PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLN 4556

Query: 1933 SRYQREIDKLRQRPY----------GSHRETQTECEWTVDTSK 1965
             R+Q  ++K  QR            G H E +   +W  DT +
Sbjct: 4557 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 234/1345 (17%), Positives = 513/1345 (38%), Gaps = 173/1345 (12%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2643 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2702

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2703 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2757

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE   A+    L      P  R +++     
Sbjct: 2758 -------------QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2804

Query: 992  ILQ-------EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK-------NTKIEVL 1037
            + Q       + +D      + + +S  Y   L  +   L DL  K       +T  + +
Sbjct: 2805 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2864

Query: 1038 EEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLAS---LEELKRQAELDGKSAK 1094
             ++L  A+    E   + K     ++  QA C    A +       EL RQ E   KS K
Sbjct: 2865 NQQLETAQKMKQEIQQEKK----QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2920

Query: 1095 QNLDKCYGQIKELN---------EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA 1145
                K    ++ L          ++++R      D K+  ++       + +  + L K 
Sbjct: 2921 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2980

Query: 1146 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH---YNEE 1202
             +   + L  Q    EK I E E       +LL+ +G+ K   + +L  ++ +   +N++
Sbjct: 2981 HKDFSKTLTAQSHMYEKTIAEGE------NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 3034

Query: 1203 MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKD--EIVRLNDSI 1260
            +    NK +  +        E +++ ++  + L   +D+      ++K   +     +SI
Sbjct: 3035 VKERENKLKESL--------EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI 3086

Query: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
             +    ++  +++    +   +         EI+ + V    +++N    Q ++   + +
Sbjct: 3087 AKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV----TDENKSLIQKVDMVTEQL 3142

Query: 1321 QDKNKEIERLKAEFQE------EAKRRWEYENELSKVRNNYDEEIISLK--NQFETEINI 1372
              K   +E +  +F+E      E+KR+ +   E   + ++   +  S K     +T+   
Sbjct: 3143 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3202

Query: 1373 TKTTIHQLTMQK------------EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTT 1420
             +   HQ+ + K             + TS    Q++ + +E+ +LS+++    + L    
Sbjct: 3203 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3262

Query: 1421 ENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKN 1480
            + +   +  I+       E+  +  + + EL  +  +  +     KQ      +TI+   
Sbjct: 3263 QGIGHFQNTIR-------EMFSQFAEFDDELDSMAPVGRDAETLQKQK-----ETIKAFL 3310

Query: 1481 KEIERLKQLIDKETNDRKCL---EDENARLQRVQYDLQKANSSATETINKLKVQEQE--- 1534
            K++E L    D      K +   E+ +  L  ++ DL+  +    + +++ + +E++   
Sbjct: 3311 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3370

Query: 1535 -LTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK 1593
             + RL   Y ++ +E ++  Q     + S   + ++ + + ++LN  K    E+    + 
Sbjct: 3371 TIKRLEEFYSKL-KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 3429

Query: 1594 LEEELEGMRRSLKEQAIKITN---LTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRT 1650
             ++++  + + L + A K T+   L   L+  +   K     + Q+   L   L    R 
Sbjct: 3430 KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRF 3489

Query: 1651 QEELRRLSS------EVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIE 1704
            Q+ L  L S      E+ A ++    E + VK      +  Q+ ++D+  ++   K E E
Sbjct: 3490 QDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE 3549

Query: 1705 RLQSLTENLTK--------------EHLMLEEELRNLRLEYDDLRRGRSEADSDKNATIL 1750
            ++ +  E   K              E L+ + E RN +LE      G S      + T+ 
Sbjct: 3550 KIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLE------GISVVAQQFHETLE 3603

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE--SKNQCTQV 1808
             L   L     R +  + +     +  E + Q  +  +   +  +  + +  S  Q  +V
Sbjct: 3604 PLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH-KALEDDIINHNKHLHQAVSIGQSLKV 3662

Query: 1809 VQERE-----------SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEK 1857
            +  RE           S +  I++ E+  +R + L+  L  AK   E E  +   L    
Sbjct: 3663 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL---- 3718

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
             ++ + L++   Q     E + K +SE    + +    +  ++  QA +  + E  ++  
Sbjct: 3719 NEVHDKLSKLSVQ-DYSTEGLWKQQSELRVLQEDILLRKQNVD--QALLNGL-ELLKQTT 3774

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTA 1977
             D     Q +LE  ++RY ++I KL      +  +          T + +   L K    
Sbjct: 3775 GDEVLIIQDKLEAIKARY-KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3833

Query: 1978 MQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA--------SASPKEKY 2029
            +  YE Q++      +     K +++ A   +  L     ++ A        +    EK 
Sbjct: 3834 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3893

Query: 2030 SLVEAKRKKLISPESTVMLLEAQAA 2054
               + +R +L+S   T  + E  AA
Sbjct: 3894 VAEDNERYRLVSDTITQKVEEIDAA 3918



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 187/966 (19%), Positives = 383/966 (39%), Gaps = 146/966 (15%)

Query: 996  AADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A+ + A+  +L  R  +      E L  +E+LK K    E L E+L+   +  ++   + 
Sbjct: 2325 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEV 2384

Query: 1056 KF-------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                     L Q +Q+  +E  + K  L  L  L ++    G  + + L      + E  
Sbjct: 2385 DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL------VLEKT 2438

Query: 1109 EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA-IKEK 1167
              +++   E+ED  + +K       +Q + +  L K+ +       W K  ++K  I + 
Sbjct: 2439 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLK------SWIKETTKKVPIVQP 2492

Query: 1168 EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS--NLRNKYETEINI--------- 1216
             +  E L   L++    + ++  +  +++   N  +S  NL +   T             
Sbjct: 2493 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2552

Query: 1217 ------TKTTIKEISMQKEDDSKNLRNQLDRLSRENRDL----KDEIVRLNDSILQATEQ 1266
                  T T  +E    K   S  ++  +  +S    DL    KD+I  LN  + +   Q
Sbjct: 2553 VLNGEGTATNTEEFWANKGLTS--IKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--Q 2608

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
            + + E +A+ Q       +QK      + +Q                 EA KT  ++NK 
Sbjct: 2609 KAQEESSAMMQW------LQKMNKTATKWQQTPAPTDT----------EAVKTQVEQNKS 2652

Query: 1327 IERLKAEFQEEAKRRWEYENELSKV-RNNYDEEIISLKNQFETEINITKTTIHQLTM--- 1382
             E   AE ++   +  E +++L+++   N D        Q  TEI+     ++QLT+   
Sbjct: 2653 FE---AELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2709

Query: 1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQ 1442
            QK E++S    Q   +  + +    E + + + L   + +   +    QQ +    E + 
Sbjct: 2710 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2769

Query: 1443 RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR--KCL 1500
            RK Q E    Q+T     + +  +   D + + I    +++  + Q  D  T     +C 
Sbjct: 2770 RKPQYE----QLTA--AGQGILSRPGEDPSLRGIV--KEQLAAVTQKWDSLTGQLSDRCD 2821

Query: 1501 EDENARLQRVQYD--LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
              + A ++  QY   L+  +   ++  NKL                VS      +Q +  
Sbjct: 2822 WIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA-----------VSTHPDAMNQQLET 2870

Query: 1559 FQNSLKELQLQKQKVE------EELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI 1612
             Q   +E+Q +K++++      E+L+ L +    +   + +L  +LEG+ +S K+   K 
Sbjct: 2871 AQKMKQEIQQEKKQIKVAQALCEDLSALVK----EEYLKAELSRQLEGILKSFKDVEQKA 2926

Query: 1613 TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQ 1672
             N  Q L+ A      S    +Q        L  K+  Q +   +S++++ L        
Sbjct: 2927 ENHVQHLQSACA----SSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-------- 2974

Query: 1673 ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732
            ES+ + H   + F K +  +S    ++  E E L   T+   K  L L+  L  ++  +D
Sbjct: 2975 ESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--LNTIKTNWD 3029

Query: 1733 DLRRGRSEADSDKNATI---LELRSQLQISNNRTLELQGLINDLQ-----RERENLRQEI 1784
               +   E ++    ++   L+ + Q++       + Q  + +++      E EN   ++
Sbjct: 3030 TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL 3089

Query: 1785 EKFQKQALEASNRIQESKNQCTQ-----------VVQERESLLVKIK-VLEQDKARLQRL 1832
            +  QK+  +    ++   N               V  E +SL+ K+  V EQ  ++   L
Sbjct: 3090 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3149

Query: 1833 EDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIRKIESE 1884
            E+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++ ++ +
Sbjct: 3150 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3209

Query: 1885 REKSER 1890
             + ++R
Sbjct: 3210 VDLAKR 3215



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 222/1228 (18%), Positives = 467/1228 (38%), Gaps = 188/1228 (15%)

Query: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF- 917
            ++  +   W   +KQ+  R   L++ +++   Y++  +    W+    + Q++LE +KF 
Sbjct: 3020 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI---DKCQNNLEEIKFC 3076

Query: 918  ----GDSNTVMRFLNEQKNLHSE---ISGKRDKSEEVQKIAELCANSIKDYELQLASYTS 970
                   N++ +  + QK +      +    + +  +  + E+    + D    L     
Sbjct: 3077 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 3136

Query: 971  GLETLLNIPIKRTMIQSPSGVI--LQEAADVHARYIELLTRSGDYYRFLSEML---KSLE 1025
             +   L+   K+  +++ +      QE +    R ++      D +  L       K L 
Sbjct: 3137 MVTEQLH--SKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3194

Query: 1026 DLKLKNTKIEVLEEEL----RLARDANSENCNKNKFLDQNL-------------QKYQAE 1068
             L+ +   ++ L+ ++    RLA+D   E  +     D  L             Q+   +
Sbjct: 3195 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3254

Query: 1069 CSQFKAKLASL--------EELKRQAELD---------GKSAKQNLDKCYGQIKELNEKI 1111
            CS  + KL  +        E   + AE D         G+ A + L K    IK   +K+
Sbjct: 3255 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA-ETLQKQKETIKAFLKKL 3313

Query: 1112 TRLTYEIEDEKRRRKSVEDRFDQQ------KNDYDQLQKARQCEKENLGWQKLESE---- 1161
              L    ++  +  K +    +        K D + L K  QC K     Q  E +    
Sbjct: 3314 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSK--QCNKLLDRAQAREEQVEGT 3371

Query: 1162 -KAIKEKEYEIERLRVLLQEE----------GTRKREYENELAKVRNHYNEEMSNLRNKY 1210
             K ++E   +++   +LLQ+           G        +L   +    EE+  L+ K 
Sbjct: 3372 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3431

Query: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLD----RLSRENRDLKDEIVRLNDSILQATEQ 1266
            +    + +  I+  S  K   ++ L + LD    R    N+ +     +L +++L    +
Sbjct: 3432 QDVNWLGQGLIQ--SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC-GR 3488

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
             + A E+ L       E++  ++    E K V  Q  E     ++ L++   T++   +E
Sbjct: 3489 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL-QRLLDDRKSTVEVIKRE 3547

Query: 1327 IERL--KAEFQEEAK---------RRWEYENELSKVRNNYDEEIISLKNQFE---TEINI 1372
             E++   AE  ++ K          RWE     ++ RN   E I  +  QF      +N 
Sbjct: 3548 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3607

Query: 1373 TKTTIHQLTM----------QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTEN 1422
              TTI +  +          + EE  + ++A  D++   N+ L + +     ++ Q+ + 
Sbjct: 3608 WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV-----SIGQSLKV 3662

Query: 1423 L-RRVEEDIQQQKATGSEV----SQRKQQLEVELRQV----TQMRTEESVRYKQSLDDAA 1473
            L  R ++D+ Q K   S+V     Q K     EL Q      ++  E+ V     L++  
Sbjct: 3663 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3722

Query: 1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATET--------- 1524
              +   + +    + L  +++  R   ED   R Q V   L        +T         
Sbjct: 3723 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3782

Query: 1525 --INKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLK- 1581
              +  +K + +++T+L  D  +  ++     Q   R  ++ +EL     KVE EL   + 
Sbjct: 3783 DKLEAIKARYKDITKLSTDVAKTLEQAL---QLARRLHSTHEELCTWLDKVEVELLSYET 3839

Query: 1582 -----RTASEDSCKRKKLEEELEGMRR---SLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
                   AS+   + K+L++E +  +    SL E +  +  L     +  + K  +ED+ 
Sbjct: 3840 QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN- 3898

Query: 1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693
                               E  RL S+       + Q+ E +  A LR++ F +A + + 
Sbjct: 3899 -------------------ERYRLVSDT------ITQKVEEIDAAILRSQQFDQAADAEL 3933

Query: 1694 RSLNESKIEIERLQS--LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD-KNATIL 1750
              + E++ ++  L    L ++ T   L +++      L + D+     ++      A   
Sbjct: 3934 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSE 3993

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ 1810
            E +  ++   ++ L+    I  +  ER    +  +    Q  E    +     +   ++ 
Sbjct: 3994 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 4053

Query: 1811 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV-KQRLEC---EKQQIQNDLNQ 1866
            +  +  ++ + L Q +   ++L + +   K  ++   +   Q LE    E   IQ     
Sbjct: 4054 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 4113

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR---------KL 1917
              T YS+ +E ++K     +++  +      +I+++   ++RI ER R+         K+
Sbjct: 4114 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKI 4173

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            ++   E ++ +  +  + Q   + L+QR
Sbjct: 4174 KEQISENKN-VSVDMEKLQPLYETLKQR 4200



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 210/1176 (17%), Positives = 463/1176 (39%), Gaps = 157/1176 (13%)

Query: 858  EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            +K+  +  R++ I K        LE+ ++  R     ++  C WL   +    S E+   
Sbjct: 3783 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYET--- 3839

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA-NSIKDYELQLASYTS--GLET 974
                   + L  ++   +++  K  K E     A L + N +    L+L  + +  GLE 
Sbjct: 3840 -------QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3892

Query: 975  LLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKI 1034
            ++    +R  + S +  I Q+  ++ A  +    RS  + +     L  + + + K   +
Sbjct: 3893 MVAEDNERYRLVSDT--ITQKVEEIDAAIL----RSQQFDQAADAELSWITETEKKLMSL 3946

Query: 1035 EVLEEELRLARDANSENCNKNKFLDQNLQKYQAEC-----SQFKAKLASLEELKRQAELD 1089
                 ++RL +D  S      K     + +++        S  K   A  EE K+     
Sbjct: 3947 G----DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ----- 3997

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
              S K+ LDK    + +  + I ++  E   +  R +S+ ++F +   +        Q  
Sbjct: 3998 --SMKKKLDK----VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 4051

Query: 1150 KENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
               L    LE E  +++++ E  +LR L+ E      +      ++      E  +++ K
Sbjct: 4052 ISQLPAPALEYE-TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEK 4110

Query: 1210 YETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR 1269
            Y             +  Q ++D K     LD    ++    D+I ++ +S+ +  E+ R+
Sbjct: 4111 Y--------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4162

Query: 1270 AEENALQQKACGSEIMQKKQ-HLEIE----LKQVMQQRSEDNARHKQSLEE--AAKTIQD 1322
                + + +    +I + K   +++E    L + ++QR E+        ++  +AK +QD
Sbjct: 4163 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4222

Query: 1323 KNKEI----ERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH 1378
            K  ++    E +    +E   +  +      K   ++   I+++K+  +   ++    I 
Sbjct: 4223 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4282

Query: 1379 -QLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATG 1437
              +  Q++E     R +ID L  E   +      L     +  + +  V++ I +  +  
Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4340

Query: 1438 SEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD------DAA----KTIQDKNKEIERLK 1487
              +++  +    +L +  Q     +V+Y+  L       D A     ++     ++E +K
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQA----AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4396

Query: 1488 QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547
            Q I++    +     +   ++R+ +  +      TE  +K  VQ+  L  L++ ++ + +
Sbjct: 4397 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP-LMELKLIWDSL-E 4454

Query: 1548 ERTVKDQD--------ITRFQNSLKELQ---------LQKQK--------VEEELNRLKR 1582
            ER +  Q         + +FQ++L EL          L +QK        +E EL +   
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HH 4513

Query: 1583 TASEDSCKRKKLEEELEGMRRSLKEQAI--KITNLTQQLEQASIVKKRSEDDLRQQRDVL 1640
                D    +   E +      L E +   + +NL  +LE  +   +   +   Q++  L
Sbjct: 4514 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4573

Query: 1641 DGHLREKQRTQEELRRLSSEVEALRRQLLQEQ------ESVKQAHLRNEHFQKAIEDKSR 1694
            DG LR+ +    E+  L   +    R LL  +      E+ K+    N H +     +++
Sbjct: 4574 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ--LNVHMEVCAAFEAK 4631

Query: 1695 SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATI---LE 1751
                  +  +  Q L          +++++ NL+ +++ +    +E  +     +   +E
Sbjct: 4632 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4691

Query: 1752 LRSQLQISNNRTLELQGLINDLQR-------------ERENLRQEIEKFQKQALEASNRI 1798
              + LQ   N   + +  +N   R             E +    E+   ++Q +E     
Sbjct: 4692 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4751

Query: 1799 QESK--NQCTQVVQERESLLVKI-----KVLEQDKARLQRLEDELNRAKSTLEAETRVKQ 1851
               K  +Q   VV  + +LL+ +     KV+++   R + L+D   RAK   EA +++ +
Sbjct: 4752 THLKYFSQKQDVVLIK-NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4810

Query: 1852 RLECEKQ------QIQNDLNQWKTQYSRKEEAIRKIESERE---------KSEREKNSLR 1896
             LE  ++      +I ND ++ KTQ ++ +E  + + ++           +S +EK SL 
Sbjct: 4811 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4870

Query: 1897 SEIERLQAEIKRIEER----CRRKLEDSTRETQSQL 1928
             +  +L   +  + ++    C + +E   +  ++ L
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4906



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 186/959 (19%), Positives = 361/959 (37%), Gaps = 164/959 (17%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 4145 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 4205 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4264

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 4265 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4315

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 4316 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4368

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 4369 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4427

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 4428 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4481

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 4482 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4540

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4541 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4597

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4598 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4657

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK-- 1218
            ++ I   + + E +   L E  T+  E  N LA   ++  ++  N   + E  +N+    
Sbjct: 4658 DQDINNLKEKWESVETKLNERKTKLEEALN-LAMEFHNSLQDFINWLTQAEQTLNVASRP 4716

Query: 1219 -----TTIKEISMQK--EDDSKNLRNQLDRLSRENRDL-----KDEIVRLN--------- 1257
                 T + +I   K   ++  + R Q+  L +    L     K ++V +          
Sbjct: 4717 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4776

Query: 1258 -DSILQATEQRRR----AEENALQQKACGSEIM------QKKQHLEIELKQVMQQRSEDN 1306
             + ++Q   +R R    A + A Q     S++M      +K    E+E+     +     
Sbjct: 4777 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4836

Query: 1307 ARHKQSLEE--AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD-------- 1356
            A+HK+  +   A  ++ D      R   E    A    + ++ LS++R+ +D        
Sbjct: 4837 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4896

Query: 1357 -----EEIISLKNQFETEINITKTTIHQLTMQKEED--TSGYRAQIDNLTRENRSLSEEI 1409
                 EE +    QF   +      ++++  Q  ED    G    + NL   +++  +E+
Sbjct: 4897 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4956

Query: 1410 KRLKNTLTQTTENLRRV----EEDIQQQKATGSEVSQR-----------KQQLEVELRQV 1454
             +  +++     + R +     +D    K    E+S R           + +LE  LRQ 
Sbjct: 4957 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 5016

Query: 1455 TQMRT------------EESVRYKQSL---DDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
             +  +            E+++R+   L   +DA +T+ D++KE   +K+L +K     K
Sbjct: 5017 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF--MKKLEEKRAELNK 5073



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 193/1127 (17%), Positives = 438/1127 (38%), Gaps = 186/1127 (16%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 4363 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4421

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 4422 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4453

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 4454 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4505

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4565

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4566 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4612

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4613 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4666

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4667 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4725

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4726 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4773

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4774 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4827

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        + 
Sbjct: 4828 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT-----SLA 4870

Query: 1106 ELNEKITRLTYEIED--EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA 1163
            + N K+  +  E+ D  +    KSVE +        ++L++A          Q  ++ +A
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQ--------NKLEEALL-----FSGQFTDALQA 4917

Query: 1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH--YNEEMSNLRNKYETEINITKTTI 1221
            + +  Y +E     L E+     + +  +  + NH  + +E+     K  + +   K + 
Sbjct: 4918 LIDWLYRVE---PQLAEDQPVHGDIDLVMNLIDNHKAFQKEL----GKRTSSVQALKRSA 4970

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
            +E+     DDS  ++ Q+  LS              +++   +  ++   E AL+Q    
Sbjct: 4971 RELIEGSRDDSSWVKVQMQELSTR-----------WETVCALSISKQTRLEAALRQ---- 5015

Query: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
            +E      H  +E     +Q    +       E+A +T+ D++KE  +   E + E  + 
Sbjct: 5016 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRTLIDQHKEFMKKLEEKRAELNKA 5074

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE 1401
                + +  +   + + I ++K+     I I +    ++    ++      + +  L  +
Sbjct: 5075 TTMGDTVLAI--CHPDSITTIKHW----ITIIRARFEEVLAWAKQHQQRLASALAGLIAK 5128

Query: 1402 NRSLSEEIKRLKNTLTQTTENLRRV-EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTE 1460
               L   +  L+   T  T+  + V  ++I++ KA  +E                Q   E
Sbjct: 5129 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE---------------HQTFME 5173

Query: 1461 ESVRYKQSLDDAAKTIQDKNKEIERLKQ---LIDKETNDRKCLEDENARLQRVQYDLQKA 1517
            E  R +  +D   KT + +  +   L+    ++DK    RK     +      Q  ++  
Sbjct: 5174 EMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETK 5233

Query: 1518 NSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL 1577
            N      +N L  + Q++  L ++  R   +   + +++  F N   +  + ++K    +
Sbjct: 5234 N----PRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF--DFDIWRKKYMRWM 5287

Query: 1578 NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
            N  K++   D  +R   +++ +  R+   +  +     T +LE +++
Sbjct: 5288 NH-KKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAV 5333



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4928 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4985

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 5046 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 5102

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 5103 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 5159

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 5160 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5219

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 5220 SLYPSGSQTQIETKNPRVNLLVSKW 5244



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2822 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2849
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5588 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5615



 Score = 35.4 bits (80), Expect = 0.82
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2825 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2851
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5595 SRPGSRAGSKAGSRASSRRGSDASDFD 5621



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2798 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2841
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5573 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5615


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  609 bits (1571), Expect = e-173
 Identities = 460/1803 (25%), Positives = 884/1803 (49%), Gaps = 168/1803 (9%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1052

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 1053 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1111

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 1112 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1171

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1231

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 1232 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1291

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 1292 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1351

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1352 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1411

Query: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067
            T    Y +F  + LK LE            EEE               K L++  +++  
Sbjct: 1412 TLMTQYIKFAGDSLKRLE------------EEE---------------KSLEEEKKEHVE 1444

Query: 1068 ECSQFKAKLASLEELKRQAELDGKS--AKQNLDKCYGQIKELNEKITRLTYEIED-EKRR 1124
            +  + +  ++++ +  + AE  GK   +KQ +       +E++ K  +L+  ++  +   
Sbjct: 1445 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS-----EEISTKKEQLSEALQTIQLFL 1499

Query: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
             K  +   D+++N+ ++  K  Q E  NL +   ES K ++E +   + ++V  +    R
Sbjct: 1500 AKHGDKMTDEERNELEKQVKTLQ-ESYNLLFS--ESLKQLQESQTSGD-VKVEEKIVAER 1555

Query: 1185 KREYENELAKVRNHYNEEMSNLRNKYET-EINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
            ++EY+ +L  + +   +  + L    E   I      +K+   ++E+  K+++     L+
Sbjct: 1556 QQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA 1615

Query: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS 1303
                    E+V+  ++ L+   ++   E+ AL        I QK    +I+ +Q+     
Sbjct: 1616 --------EVVKNTENFLKENGEKLSQEDKAL--------IEQKLNEAKIKCEQL----- 1654

Query: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN-NYDEEIISL 1362
              N + +QS +E  K +    KE     A  ++  + + + EN L  + N + D E    
Sbjct: 1655 --NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1712

Query: 1363 KNQFETEINIT--KTTIHQLTMQKEEDTSGYRAQID-----NLTRENRSLSEEIKRLKNT 1415
            K++   E N T  +    +  + +E++ +G   + D       T+EN  L+++ +++K  
Sbjct: 1713 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN--LNQQYQKVK-- 1768

Query: 1416 LTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE-SVRYKQSLDDAAK 1474
              Q  + + + +  I   ++    + ++ Q L  E ++  Q   +E  V Y+ +L ++ K
Sbjct: 1769 -AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1827

Query: 1475 TIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ- 1533
             ++  +   E L++     T     L+     L+ ++      N   T+   +    E  
Sbjct: 1828 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1887

Query: 1534 -----ELTRLRIDYERVSQ-ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASED 1587
                 +L  + I   RV +  ++   +D  +   S    ++Q+ K++   +R +   S+ 
Sbjct: 1888 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQR-KLDHATDRFRSLYSKC 1946

Query: 1588 SCKRKKLEEELE----------GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQR 1637
            +     L++ ++          G+   L  QA + T      E  ++  K  +  L + +
Sbjct: 1947 NVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQLEETK 2004

Query: 1638 DVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697
              L G +  +Q   E+L++ +  +   R  LL  +  +++     +      ED S+S+N
Sbjct: 2005 -ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT---LDDIVGRYEDLSKSVN 2060

Query: 1698 ESKIEIERLQ-SLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756
            E     E+LQ +LT +L+ +   L+E L  +      L   + +     N+T L    Q 
Sbjct: 2061 ERN---EKLQITLTRSLSVQD-GLDEMLDWMGNVESSL---KEQGQVPLNSTAL----QD 2109

Query: 1757 QISNNRTLE--LQGLINDLQRERENLRQEIE--------KFQKQALEASNRIQESKNQCT 1806
             IS N  LE  + G  + +    E +++ +E          Q +  + S R  E+ ++  
Sbjct: 2110 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2169

Query: 1807 QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ 1866
            + + + E L  K+++ E    +LQ   +   +A + ++   +    L    Q+  ++  +
Sbjct: 2170 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2229

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K         +++I S    S  +K  +  +   L  + K +E+  + K E  T   Q 
Sbjct: 2230 HKKHLEVLHSLLKEISSHGLPS--DKALVLEKTNNLSKKFKEMEDTIKEKKEAVT-SCQE 2286

Query: 1927 QLE 1929
            QL+
Sbjct: 2287 QLD 2289



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 231/1243 (18%), Positives = 489/1243 (39%), Gaps = 199/1243 (16%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 3265 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 3316 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3374

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3375 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3427

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL------------ 1058
             ++   + + L + E +    T+   LEE++   +    +  N NK L            
Sbjct: 3428 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484

Query: 1059 -----DQNLQKYQAECSQ-----FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                 D+++ + + + SQ      + K  S  EL +QA  + K   ++  +    + E++
Sbjct: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3544

Query: 1109 EKITRLT---YEIE----DEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL--- 1158
            +K+++L+   Y  E     +   R   ED   +++N    L    +  K+  G + L   
Sbjct: 3545 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3604

Query: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK 1218
            +  +AIK +  +I +    L  +  +  E   +LA+  +  +EE+    +K E E+   +
Sbjct: 3605 DKLEAIKARYKDITK----LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3660

Query: 1219 TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR-------AE 1271
            T +  +  ++   ++    +L + ++ N+ L D +  ++ ++L+    R R       AE
Sbjct: 3661 TQV--LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3718

Query: 1272 ENALQQKACGSEIMQKKQHLEIEL--KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
            +N  + +     I QK + ++  +   Q   Q ++         E+   ++ D   E ++
Sbjct: 3719 DNE-RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3777

Query: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
              A+ Q               V+  +  EI+  K+  +   ++ K+    +T   EE+  
Sbjct: 3778 TSAQLQ---------------VQKTFTMEILRHKDIID---DLVKSGHKIMTACSEEEKQ 3819

Query: 1390 GYRAQIDNLTRENRSLSE-------EIKRLKNTLTQTTEN-------LRRVEEDIQQQKA 1435
              + ++D + +   ++ +       +++R ++ + Q  E        L   +  I Q  A
Sbjct: 3820 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3879

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT--------------IQDKNK 1481
               E    +QQ E E RQ+ ++  E    +K  +D   KT              IQ+K  
Sbjct: 3880 PALEYETLRQQQE-EHRQLRELIAE----HKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3934

Query: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQY--DLQKANSSATETINKLKVQEQELTRLR 1539
              + L   I ++   R    DE A  Q  Q+   + +   S    + +L+        + 
Sbjct: 3935 AADTLYSQIKEDVKKRAVALDE-AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVE 3993

Query: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCK--RKKLEEE 1597
               E++S+ + V   D+ + Q   + L   KQ+ EE + R   T  + S K  + KL++ 
Sbjct: 3994 KIKEQISENKNV-SVDMEKLQPLYETL---KQRGEEMIARSGGTDKDISAKAVQDKLDQM 4049

Query: 1598 L---EGMRRSLKEQAIKITNLTQQLEQ-------ASIVKKRSEDDLRQQRDV-LDGHLRE 1646
            +   E +   ++E+  K+ ++ +  E+         +  K ++D +R   D  +D  + +
Sbjct: 4050 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4109

Query: 1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL 1706
            +Q  QE    +  E++ L+ +L    + V   +L +E      E     + +S  E+   
Sbjct: 4110 QQ--QEAAETIREEIDGLQEEL----DIV--INLGSELIAACGEPDKPIVKKSIDELNSA 4161

Query: 1707 QSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766
                    K+ +   EE     ++Y D               +  +   + I+  +   +
Sbjct: 4162 WDSLNKAWKDRIDKLEEAMQAAVQYQD--------------GLQAVFDWVDIAGGKLASM 4207

Query: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
              +  DL+  ++ + +E+++F+ +A +    ++   +Q          LL+K    E DK
Sbjct: 4208 SPIGTDLETVKQQI-EELKQFKSEAYQQQIEMERLNHQA--------ELLLKKVTEESDK 4258

Query: 1827 ARLQRLEDELNRAKSTLEAETRVKQ-RLE------CEKQQIQNDLNQWKTQYSRKEEAIR 1879
              +Q    EL     +LE     +Q +LE       + Q   ++L  W T         +
Sbjct: 4259 HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQK 4318

Query: 1880 KIESEREKSERE---KNSLRSEIERLQAEIKRIEERCRRKLEDSTRE----TQSQLETER 1932
             +  + +  E E    + L++++   Q+ ++ + +     +E S  E     Q++LE   
Sbjct: 4319 PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLN 4378

Query: 1933 SRYQREIDKLRQRPY----------GSHRETQTECEWTVDTSK 1965
             R+Q  ++K  QR            G H E +   +W  DT +
Sbjct: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 234/1345 (17%), Positives = 513/1345 (38%), Gaps = 173/1345 (12%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2579

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE   A+    L      P  R +++     
Sbjct: 2580 -------------QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2626

Query: 992  ILQ-------EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK-------NTKIEVL 1037
            + Q       + +D      + + +S  Y   L  +   L DL  K       +T  + +
Sbjct: 2627 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2686

Query: 1038 EEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLAS---LEELKRQAELDGKSAK 1094
             ++L  A+    E   + K     ++  QA C    A +       EL RQ E   KS K
Sbjct: 2687 NQQLETAQKMKQEIQQEKK----QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2742

Query: 1095 QNLDKCYGQIKELN---------EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA 1145
                K    ++ L          ++++R      D K+  ++       + +  + L K 
Sbjct: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2802

Query: 1146 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH---YNEE 1202
             +   + L  Q    EK I E E       +LL+ +G+ K   + +L  ++ +   +N++
Sbjct: 2803 HKDFSKTLTAQSHMYEKTIAEGE------NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2856

Query: 1203 MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKD--EIVRLNDSI 1260
            +    NK +  +        E +++ ++  + L   +D+      ++K   +     +SI
Sbjct: 2857 VKERENKLKESL--------EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI 2908

Query: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
             +    ++  +++    +   +         EI+ + V    +++N    Q ++   + +
Sbjct: 2909 AKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV----TDENKSLIQKVDMVTEQL 2964

Query: 1321 QDKNKEIERLKAEFQE------EAKRRWEYENELSKVRNNYDEEIISLK--NQFETEINI 1372
              K   +E +  +F+E      E+KR+ +   E   + ++   +  S K     +T+   
Sbjct: 2965 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3024

Query: 1373 TKTTIHQLTMQK------------EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTT 1420
             +   HQ+ + K             + TS    Q++ + +E+ +LS+++    + L    
Sbjct: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3084

Query: 1421 ENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKN 1480
            + +   +  I+       E+  +  + + EL  +  +  +     KQ      +TI+   
Sbjct: 3085 QGIGHFQNTIR-------EMFSQFAEFDDELDSMAPVGRDAETLQKQK-----ETIKAFL 3132

Query: 1481 KEIERLKQLIDKETNDRKCL---EDENARLQRVQYDLQKANSSATETINKLKVQEQE--- 1534
            K++E L    D      K +   E+ +  L  ++ DL+  +    + +++ + +E++   
Sbjct: 3133 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3192

Query: 1535 -LTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK 1593
             + RL   Y ++ +E ++  Q     + S   + ++ + + ++LN  K    E+    + 
Sbjct: 3193 TIKRLEEFYSKL-KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 3251

Query: 1594 LEEELEGMRRSLKEQAIKITN---LTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRT 1650
             ++++  + + L + A K T+   L   L+  +   K     + Q+   L   L    R 
Sbjct: 3252 KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRF 3311

Query: 1651 QEELRRLSS------EVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIE 1704
            Q+ L  L S      E+ A ++    E + VK      +  Q+ ++D+  ++   K E E
Sbjct: 3312 QDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE 3371

Query: 1705 RLQSLTENLTK--------------EHLMLEEELRNLRLEYDDLRRGRSEADSDKNATIL 1750
            ++ +  E   K              E L+ + E RN +LE      G S      + T+ 
Sbjct: 3372 KIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLE------GISVVAQQFHETLE 3425

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE--SKNQCTQV 1808
             L   L     R +  + +     +  E + Q  +  +   +  +  + +  S  Q  +V
Sbjct: 3426 PLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH-KALEDDIINHNKHLHQAVSIGQSLKV 3484

Query: 1809 VQERE-----------SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEK 1857
            +  RE           S +  I++ E+  +R + L+  L  AK   E E  +   L    
Sbjct: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL---- 3540

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
             ++ + L++   Q     E + K +SE    + +    +  ++  QA +  + E  ++  
Sbjct: 3541 NEVHDKLSKLSVQ-DYSTEGLWKQQSELRVLQEDILLRKQNVD--QALLNGL-ELLKQTT 3596

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTA 1977
             D     Q +LE  ++RY ++I KL      +  +          T + +   L K    
Sbjct: 3597 GDEVLIIQDKLEAIKARY-KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655

Query: 1978 MQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA--------SASPKEKY 2029
            +  YE Q++      +     K +++ A   +  L     ++ A        +    EK 
Sbjct: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715

Query: 2030 SLVEAKRKKLISPESTVMLLEAQAA 2054
               + +R +L+S   T  + E  AA
Sbjct: 3716 VAEDNERYRLVSDTITQKVEEIDAA 3740



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 187/966 (19%), Positives = 383/966 (39%), Gaps = 146/966 (15%)

Query: 996  AADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A+ + A+  +L  R  +      E L  +E+LK K    E L E+L+   +  ++   + 
Sbjct: 2147 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEV 2206

Query: 1056 KF-------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                     L Q +Q+  +E  + K  L  L  L ++    G  + + L      + E  
Sbjct: 2207 DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL------VLEKT 2260

Query: 1109 EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA-IKEK 1167
              +++   E+ED  + +K       +Q + +  L K+ +       W K  ++K  I + 
Sbjct: 2261 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLK------SWIKETTKKVPIVQP 2314

Query: 1168 EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS--NLRNKYETEINI--------- 1216
             +  E L   L++    + ++  +  +++   N  +S  NL +   T             
Sbjct: 2315 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2374

Query: 1217 ------TKTTIKEISMQKEDDSKNLRNQLDRLSRENRDL----KDEIVRLNDSILQATEQ 1266
                  T T  +E    K   S  ++  +  +S    DL    KD+I  LN  + +   Q
Sbjct: 2375 VLNGEGTATNTEEFWANKGLTS--IKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--Q 2430

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
            + + E +A+ Q       +QK      + +Q                 EA KT  ++NK 
Sbjct: 2431 KAQEESSAMMQW------LQKMNKTATKWQQTPAPTDT----------EAVKTQVEQNKS 2474

Query: 1327 IERLKAEFQEEAKRRWEYENELSKV-RNNYDEEIISLKNQFETEINITKTTIHQLTM--- 1382
             E   AE ++   +  E +++L+++   N D        Q  TEI+     ++QLT+   
Sbjct: 2475 FE---AELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2531

Query: 1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQ 1442
            QK E++S    Q   +  + +    E + + + L   + +   +    QQ +    E + 
Sbjct: 2532 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2591

Query: 1443 RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR--KCL 1500
            RK Q E    Q+T     + +  +   D + + I    +++  + Q  D  T     +C 
Sbjct: 2592 RKPQYE----QLTA--AGQGILSRPGEDPSLRGIV--KEQLAAVTQKWDSLTGQLSDRCD 2643

Query: 1501 EDENARLQRVQYD--LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
              + A ++  QY   L+  +   ++  NKL                VS      +Q +  
Sbjct: 2644 WIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA-----------VSTHPDAMNQQLET 2692

Query: 1559 FQNSLKELQLQKQKVE------EELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI 1612
             Q   +E+Q +K++++      E+L+ L +    +   + +L  +LEG+ +S K+   K 
Sbjct: 2693 AQKMKQEIQQEKKQIKVAQALCEDLSALVK----EEYLKAELSRQLEGILKSFKDVEQKA 2748

Query: 1613 TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQ 1672
             N  Q L+ A      S    +Q        L  K+  Q +   +S++++ L        
Sbjct: 2749 ENHVQHLQSACA----SSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-------- 2796

Query: 1673 ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732
            ES+ + H   + F K +  +S    ++  E E L   T+   K  L L+  L  ++  +D
Sbjct: 2797 ESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--LNTIKTNWD 2851

Query: 1733 DLRRGRSEADSDKNATI---LELRSQLQISNNRTLELQGLINDLQ-----RERENLRQEI 1784
               +   E ++    ++   L+ + Q++       + Q  + +++      E EN   ++
Sbjct: 2852 TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL 2911

Query: 1785 EKFQKQALEASNRIQESKNQCTQ-----------VVQERESLLVKIK-VLEQDKARLQRL 1832
            +  QK+  +    ++   N               V  E +SL+ K+  V EQ  ++   L
Sbjct: 2912 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 2971

Query: 1833 EDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIRKIESE 1884
            E+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++ ++ +
Sbjct: 2972 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031

Query: 1885 REKSER 1890
             + ++R
Sbjct: 3032 VDLAKR 3037



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 222/1228 (18%), Positives = 467/1228 (38%), Gaps = 188/1228 (15%)

Query: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF- 917
            ++  +   W   +KQ+  R   L++ +++   Y++  +    W+    + Q++LE +KF 
Sbjct: 2842 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI---DKCQNNLEEIKFC 2898

Query: 918  ----GDSNTVMRFLNEQKNLHSE---ISGKRDKSEEVQKIAELCANSIKDYELQLASYTS 970
                   N++ +  + QK +      +    + +  +  + E+    + D    L     
Sbjct: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2958

Query: 971  GLETLLNIPIKRTMIQSPSGVI--LQEAADVHARYIELLTRSGDYYRFLSEML---KSLE 1025
             +   L+   K+  +++ +      QE +    R ++      D +  L       K L 
Sbjct: 2959 MVTEQLH--SKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 3016

Query: 1026 DLKLKNTKIEVLEEEL----RLARDANSENCNKNKFLDQNL-------------QKYQAE 1068
             L+ +   ++ L+ ++    RLA+D   E  +     D  L             Q+   +
Sbjct: 3017 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3076

Query: 1069 CSQFKAKLASL--------EELKRQAELD---------GKSAKQNLDKCYGQIKELNEKI 1111
            CS  + KL  +        E   + AE D         G+ A + L K    IK   +K+
Sbjct: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA-ETLQKQKETIKAFLKKL 3135

Query: 1112 TRLTYEIEDEKRRRKSVEDRFDQQ------KNDYDQLQKARQCEKENLGWQKLESE---- 1161
              L    ++  +  K +    +        K D + L K  QC K     Q  E +    
Sbjct: 3136 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSK--QCNKLLDRAQAREEQVEGT 3193

Query: 1162 -KAIKEKEYEIERLRVLLQEE----------GTRKREYENELAKVRNHYNEEMSNLRNKY 1210
             K ++E   +++   +LLQ+           G        +L   +    EE+  L+ K 
Sbjct: 3194 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 3253

Query: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLD----RLSRENRDLKDEIVRLNDSILQATEQ 1266
            +    + +  I+  S  K   ++ L + LD    R    N+ +     +L +++L    +
Sbjct: 3254 QDVNWLGQGLIQ--SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC-GR 3310

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
             + A E+ L       E++  ++    E K V  Q  E     ++ L++   T++   +E
Sbjct: 3311 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL-QRLLDDRKSTVEVIKRE 3369

Query: 1327 IERL--KAEFQEEAK---------RRWEYENELSKVRNNYDEEIISLKNQFE---TEINI 1372
             E++   AE  ++ K          RWE     ++ RN   E I  +  QF      +N 
Sbjct: 3370 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3429

Query: 1373 TKTTIHQLTM----------QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTEN 1422
              TTI +  +          + EE  + ++A  D++   N+ L + +     ++ Q+ + 
Sbjct: 3430 WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV-----SIGQSLKV 3484

Query: 1423 L-RRVEEDIQQQKATGSEV----SQRKQQLEVELRQV----TQMRTEESVRYKQSLDDAA 1473
            L  R ++D+ Q K   S+V     Q K     EL Q      ++  E+ V     L++  
Sbjct: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3544

Query: 1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATET--------- 1524
              +   + +    + L  +++  R   ED   R Q V   L        +T         
Sbjct: 3545 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3604

Query: 1525 --INKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLK- 1581
              +  +K + +++T+L  D  +  ++     Q   R  ++ +EL     KVE EL   + 
Sbjct: 3605 DKLEAIKARYKDITKLSTDVAKTLEQAL---QLARRLHSTHEELCTWLDKVEVELLSYET 3661

Query: 1582 -----RTASEDSCKRKKLEEELEGMRR---SLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
                   AS+   + K+L++E +  +    SL E +  +  L     +  + K  +ED+ 
Sbjct: 3662 QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN- 3720

Query: 1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693
                               E  RL S+       + Q+ E +  A LR++ F +A + + 
Sbjct: 3721 -------------------ERYRLVSDT------ITQKVEEIDAAILRSQQFDQAADAEL 3755

Query: 1694 RSLNESKIEIERLQS--LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD-KNATIL 1750
              + E++ ++  L    L ++ T   L +++      L + D+     ++      A   
Sbjct: 3756 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSE 3815

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ 1810
            E +  ++   ++ L+    I  +  ER    +  +    Q  E    +     +   ++ 
Sbjct: 3816 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 3875

Query: 1811 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV-KQRLEC---EKQQIQNDLNQ 1866
            +  +  ++ + L Q +   ++L + +   K  ++   +   Q LE    E   IQ     
Sbjct: 3876 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 3935

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR---------KL 1917
              T YS+ +E ++K     +++  +      +I+++   ++RI ER R+         K+
Sbjct: 3936 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKI 3995

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            ++   E ++ +  +  + Q   + L+QR
Sbjct: 3996 KEQISENKN-VSVDMEKLQPLYETLKQR 4022



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 210/1176 (17%), Positives = 463/1176 (39%), Gaps = 157/1176 (13%)

Query: 858  EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            +K+  +  R++ I K        LE+ ++  R     ++  C WL   +    S E+   
Sbjct: 3605 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYET--- 3661

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA-NSIKDYELQLASYTS--GLET 974
                   + L  ++   +++  K  K E     A L + N +    L+L  + +  GLE 
Sbjct: 3662 -------QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3714

Query: 975  LLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKI 1034
            ++    +R  + S +  I Q+  ++ A  +    RS  + +     L  + + + K   +
Sbjct: 3715 MVAEDNERYRLVSDT--ITQKVEEIDAAIL----RSQQFDQAADAELSWITETEKKLMSL 3768

Query: 1035 EVLEEELRLARDANSENCNKNKFLDQNLQKYQAEC-----SQFKAKLASLEELKRQAELD 1089
                 ++RL +D  S      K     + +++        S  K   A  EE K+     
Sbjct: 3769 G----DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ----- 3819

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
              S K+ LDK    + +  + I ++  E   +  R +S+ ++F +   +        Q  
Sbjct: 3820 --SMKKKLDK----VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3873

Query: 1150 KENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
               L    LE E  +++++ E  +LR L+ E      +      ++      E  +++ K
Sbjct: 3874 ISQLPAPALEYE-TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEK 3932

Query: 1210 YETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR 1269
            Y             +  Q ++D K     LD    ++    D+I ++ +S+ +  E+ R+
Sbjct: 3933 Y--------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984

Query: 1270 AEENALQQKACGSEIMQKKQ-HLEIE----LKQVMQQRSEDNARHKQSLEE--AAKTIQD 1322
                + + +    +I + K   +++E    L + ++QR E+        ++  +AK +QD
Sbjct: 3985 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4044

Query: 1323 KNKEI----ERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH 1378
            K  ++    E +    +E   +  +      K   ++   I+++K+  +   ++    I 
Sbjct: 4045 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104

Query: 1379 -QLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATG 1437
              +  Q++E     R +ID L  E   +      L     +  + +  V++ I +  +  
Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4162

Query: 1438 SEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD------DAA----KTIQDKNKEIERLK 1487
              +++  +    +L +  Q     +V+Y+  L       D A     ++     ++E +K
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQA----AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4218

Query: 1488 QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547
            Q I++    +     +   ++R+ +  +      TE  +K  VQ+  L  L++ ++ + +
Sbjct: 4219 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP-LMELKLIWDSL-E 4276

Query: 1548 ERTVKDQD--------ITRFQNSLKELQ---------LQKQK--------VEEELNRLKR 1582
            ER +  Q         + +FQ++L EL          L +QK        +E EL +   
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HH 4335

Query: 1583 TASEDSCKRKKLEEELEGMRRSLKEQAI--KITNLTQQLEQASIVKKRSEDDLRQQRDVL 1640
                D    +   E +      L E +   + +NL  +LE  +   +   +   Q++  L
Sbjct: 4336 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4395

Query: 1641 DGHLREKQRTQEELRRLSSEVEALRRQLLQEQ------ESVKQAHLRNEHFQKAIEDKSR 1694
            DG LR+ +    E+  L   +    R LL  +      E+ K+    N H +     +++
Sbjct: 4396 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ--LNVHMEVCAAFEAK 4453

Query: 1695 SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATI---LE 1751
                  +  +  Q L          +++++ NL+ +++ +    +E  +     +   +E
Sbjct: 4454 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4513

Query: 1752 LRSQLQISNNRTLELQGLINDLQR-------------ERENLRQEIEKFQKQALEASNRI 1798
              + LQ   N   + +  +N   R             E +    E+   ++Q +E     
Sbjct: 4514 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4573

Query: 1799 QESK--NQCTQVVQERESLLVKI-----KVLEQDKARLQRLEDELNRAKSTLEAETRVKQ 1851
               K  +Q   VV  + +LL+ +     KV+++   R + L+D   RAK   EA +++ +
Sbjct: 4574 THLKYFSQKQDVVLIK-NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4632

Query: 1852 RLECEKQ------QIQNDLNQWKTQYSRKEEAIRKIESERE---------KSEREKNSLR 1896
             LE  ++      +I ND ++ KTQ ++ +E  + + ++           +S +EK SL 
Sbjct: 4633 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4692

Query: 1897 SEIERLQAEIKRIEER----CRRKLEDSTRETQSQL 1928
             +  +L   +  + ++    C + +E   +  ++ L
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 186/959 (19%), Positives = 361/959 (37%), Gaps = 164/959 (17%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 3967 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 4027 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4086

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 4087 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4137

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 4138 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4190

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 4191 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4249

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 4250 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4303

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 4304 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4362

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4363 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4419

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4420 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4479

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK-- 1218
            ++ I   + + E +   L E  T+  E  N LA   ++  ++  N   + E  +N+    
Sbjct: 4480 DQDINNLKEKWESVETKLNERKTKLEEALN-LAMEFHNSLQDFINWLTQAEQTLNVASRP 4538

Query: 1219 -----TTIKEISMQK--EDDSKNLRNQLDRLSRENRDL-----KDEIVRLN--------- 1257
                 T + +I   K   ++  + R Q+  L +    L     K ++V +          
Sbjct: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598

Query: 1258 -DSILQATEQRRR----AEENALQQKACGSEIM------QKKQHLEIELKQVMQQRSEDN 1306
             + ++Q   +R R    A + A Q     S++M      +K    E+E+     +     
Sbjct: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658

Query: 1307 ARHKQSLEE--AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD-------- 1356
            A+HK+  +   A  ++ D      R   E    A    + ++ LS++R+ +D        
Sbjct: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718

Query: 1357 -----EEIISLKNQFETEINITKTTIHQLTMQKEED--TSGYRAQIDNLTRENRSLSEEI 1409
                 EE +    QF   +      ++++  Q  ED    G    + NL   +++  +E+
Sbjct: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778

Query: 1410 KRLKNTLTQTTENLRRV----EEDIQQQKATGSEVSQR-----------KQQLEVELRQV 1454
             +  +++     + R +     +D    K    E+S R           + +LE  LRQ 
Sbjct: 4779 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4838

Query: 1455 TQMRT------------EESVRYKQSL---DDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
             +  +            E+++R+   L   +DA +T+ D++KE   +K+L +K     K
Sbjct: 4839 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF--MKKLEEKRAELNK 4895



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 193/1127 (17%), Positives = 438/1127 (38%), Gaps = 186/1127 (16%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 4185 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4243

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 4244 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4275

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 4276 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4327

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4388 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4488

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4489 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4547

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4548 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4595

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4649

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        + 
Sbjct: 4650 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT-----SLA 4692

Query: 1106 ELNEKITRLTYEIED--EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA 1163
            + N K+  +  E+ D  +    KSVE +        ++L++A          Q  ++ +A
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQ--------NKLEEALL-----FSGQFTDALQA 4739

Query: 1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH--YNEEMSNLRNKYETEINITKTTI 1221
            + +  Y +E     L E+     + +  +  + NH  + +E+     K  + +   K + 
Sbjct: 4740 LIDWLYRVE---PQLAEDQPVHGDIDLVMNLIDNHKAFQKEL----GKRTSSVQALKRSA 4792

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
            +E+     DDS  ++ Q+  LS              +++   +  ++   E AL+Q    
Sbjct: 4793 RELIEGSRDDSSWVKVQMQELSTR-----------WETVCALSISKQTRLEAALRQ---- 4837

Query: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
            +E      H  +E     +Q    +       E+A +T+ D++KE  +   E + E  + 
Sbjct: 4838 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRTLIDQHKEFMKKLEEKRAELNKA 4896

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE 1401
                + +  +   + + I ++K+     I I +    ++    ++      + +  L  +
Sbjct: 4897 TTMGDTVLAI--CHPDSITTIKHW----ITIIRARFEEVLAWAKQHQQRLASALAGLIAK 4950

Query: 1402 NRSLSEEIKRLKNTLTQTTENLRRV-EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTE 1460
               L   +  L+   T  T+  + V  ++I++ KA  +E                Q   E
Sbjct: 4951 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE---------------HQTFME 4995

Query: 1461 ESVRYKQSLDDAAKTIQDKNKEIERLKQ---LIDKETNDRKCLEDENARLQRVQYDLQKA 1517
            E  R +  +D   KT + +  +   L+    ++DK    RK     +      Q  ++  
Sbjct: 4996 EMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETK 5055

Query: 1518 NSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL 1577
            N      +N L  + Q++  L ++  R   +   + +++  F N   +  + ++K    +
Sbjct: 5056 N----PRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF--DFDIWRKKYMRWM 5109

Query: 1578 NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
            N  K++   D  +R   +++ +  R+   +  +     T +LE +++
Sbjct: 5110 NH-KKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAV 5155



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4750 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 4868 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4924

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 4925 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 4981

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 4982 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5041

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 5042 SLYPSGSQTQIETKNPRVNLLVSKW 5066



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2822 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2849
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5410 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5437



 Score = 35.4 bits (80), Expect = 0.82
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2825 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2851
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5417 SRPGSRAGSKAGSRASSRRGSDASDFD 5443



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2798 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2841
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5395 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5437


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  609 bits (1571), Expect = e-173
 Identities = 460/1803 (25%), Positives = 884/1803 (49%), Gaps = 168/1803 (9%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085

Query: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067
            T    Y +F  + LK LE            EEE               K L++  +++  
Sbjct: 1086 TLMTQYIKFAGDSLKRLE------------EEE---------------KSLEEEKKEHVE 1118

Query: 1068 ECSQFKAKLASLEELKRQAELDGKS--AKQNLDKCYGQIKELNEKITRLTYEIED-EKRR 1124
            +  + +  ++++ +  + AE  GK   +KQ +       +E++ K  +L+  ++  +   
Sbjct: 1119 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS-----EEISTKKEQLSEALQTIQLFL 1173

Query: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
             K  +   D+++N+ ++  K  Q E  NL +   ES K ++E +   + ++V  +    R
Sbjct: 1174 AKHGDKMTDEERNELEKQVKTLQ-ESYNLLFS--ESLKQLQESQTSGD-VKVEEKIVAER 1229

Query: 1185 KREYENELAKVRNHYNEEMSNLRNKYET-EINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
            ++EY+ +L  + +   +  + L    E   I      +K+   ++E+  K+++     L+
Sbjct: 1230 QQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA 1289

Query: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS 1303
                    E+V+  ++ L+   ++   E+ AL        I QK    +I+ +Q+     
Sbjct: 1290 --------EVVKNTENFLKENGEKLSQEDKAL--------IEQKLNEAKIKCEQL----- 1328

Query: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN-NYDEEIISL 1362
              N + +QS +E  K +    KE     A  ++  + + + EN L  + N + D E    
Sbjct: 1329 --NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1386

Query: 1363 KNQFETEINIT--KTTIHQLTMQKEEDTSGYRAQID-----NLTRENRSLSEEIKRLKNT 1415
            K++   E N T  +    +  + +E++ +G   + D       T+EN  L+++ +++K  
Sbjct: 1387 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN--LNQQYQKVK-- 1442

Query: 1416 LTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE-SVRYKQSLDDAAK 1474
              Q  + + + +  I   ++    + ++ Q L  E ++  Q   +E  V Y+ +L ++ K
Sbjct: 1443 -AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1501

Query: 1475 TIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ- 1533
             ++  +   E L++     T     L+     L+ ++      N   T+   +    E  
Sbjct: 1502 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1561

Query: 1534 -----ELTRLRIDYERVSQ-ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASED 1587
                 +L  + I   RV +  ++   +D  +   S    ++Q+ K++   +R +   S+ 
Sbjct: 1562 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQR-KLDHATDRFRSLYSKC 1620

Query: 1588 SCKRKKLEEELE----------GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQR 1637
            +     L++ ++          G+   L  QA + T      E  ++  K  +  L + +
Sbjct: 1621 NVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQLEETK 1678

Query: 1638 DVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697
              L G +  +Q   E+L++ +  +   R  LL  +  +++     +      ED S+S+N
Sbjct: 1679 -ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT---LDDIVGRYEDLSKSVN 1734

Query: 1698 ESKIEIERLQ-SLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756
            E     E+LQ +LT +L+ +   L+E L  +      L   + +     N+T L    Q 
Sbjct: 1735 ERN---EKLQITLTRSLSVQD-GLDEMLDWMGNVESSL---KEQGQVPLNSTAL----QD 1783

Query: 1757 QISNNRTLE--LQGLINDLQRERENLRQEIE--------KFQKQALEASNRIQESKNQCT 1806
             IS N  LE  + G  + +    E +++ +E          Q +  + S R  E+ ++  
Sbjct: 1784 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 1843

Query: 1807 QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ 1866
            + + + E L  K+++ E    +LQ   +   +A + ++   +    L    Q+  ++  +
Sbjct: 1844 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 1903

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K         +++I S    S  +K  +  +   L  + K +E+  + K E  T   Q 
Sbjct: 1904 HKKHLEVLHSLLKEISSHGLPS--DKALVLEKTNNLSKKFKEMEDTIKEKKEAVT-SCQE 1960

Query: 1927 QLE 1929
            QL+
Sbjct: 1961 QLD 1963



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 231/1243 (18%), Positives = 489/1243 (39%), Gaps = 199/1243 (16%)

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 2939 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 2989

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 2990 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3048

Query: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 3049 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3101

Query: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL------------ 1058
             ++   + + L + E +    T+   LEE++   +    +  N NK L            
Sbjct: 3102 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3158

Query: 1059 -----DQNLQKYQAECSQ-----FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                 D+++ + + + SQ      + K  S  EL +QA  + K   ++  +    + E++
Sbjct: 3159 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3218

Query: 1109 EKITRLT---YEIE----DEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL--- 1158
            +K+++L+   Y  E     +   R   ED   +++N    L    +  K+  G + L   
Sbjct: 3219 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3278

Query: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK 1218
            +  +AIK +  +I +    L  +  +  E   +LA+  +  +EE+    +K E E+   +
Sbjct: 3279 DKLEAIKARYKDITK----LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3334

Query: 1219 TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR-------AE 1271
            T +  +  ++   ++    +L + ++ N+ L D +  ++ ++L+    R R       AE
Sbjct: 3335 TQV--LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3392

Query: 1272 ENALQQKACGSEIMQKKQHLEIEL--KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
            +N  + +     I QK + ++  +   Q   Q ++         E+   ++ D   E ++
Sbjct: 3393 DNE-RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3451

Query: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
              A+ Q               V+  +  EI+  K+  +   ++ K+    +T   EE+  
Sbjct: 3452 TSAQLQ---------------VQKTFTMEILRHKDIID---DLVKSGHKIMTACSEEEKQ 3493

Query: 1390 GYRAQIDNLTRENRSLSE-------EIKRLKNTLTQTTEN-------LRRVEEDIQQQKA 1435
              + ++D + +   ++ +       +++R ++ + Q  E        L   +  I Q  A
Sbjct: 3494 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3553

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT--------------IQDKNK 1481
               E    +QQ E E RQ+ ++  E    +K  +D   KT              IQ+K  
Sbjct: 3554 PALEYETLRQQQE-EHRQLRELIAE----HKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3608

Query: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQY--DLQKANSSATETINKLKVQEQELTRLR 1539
              + L   I ++   R    DE A  Q  Q+   + +   S    + +L+        + 
Sbjct: 3609 AADTLYSQIKEDVKKRAVALDE-AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVE 3667

Query: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCK--RKKLEEE 1597
               E++S+ + V   D+ + Q   + L   KQ+ EE + R   T  + S K  + KL++ 
Sbjct: 3668 KIKEQISENKNV-SVDMEKLQPLYETL---KQRGEEMIARSGGTDKDISAKAVQDKLDQM 3723

Query: 1598 L---EGMRRSLKEQAIKITNLTQQLEQ-------ASIVKKRSEDDLRQQRDV-LDGHLRE 1646
            +   E +   ++E+  K+ ++ +  E+         +  K ++D +R   D  +D  + +
Sbjct: 3724 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 3783

Query: 1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL 1706
            +Q  QE    +  E++ L+ +L    + V   +L +E      E     + +S  E+   
Sbjct: 3784 QQ--QEAAETIREEIDGLQEEL----DIV--INLGSELIAACGEPDKPIVKKSIDELNSA 3835

Query: 1707 QSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766
                    K+ +   EE     ++Y D               +  +   + I+  +   +
Sbjct: 3836 WDSLNKAWKDRIDKLEEAMQAAVQYQD--------------GLQAVFDWVDIAGGKLASM 3881

Query: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
              +  DL+  ++ + +E+++F+ +A +    ++   +Q          LL+K    E DK
Sbjct: 3882 SPIGTDLETVKQQI-EELKQFKSEAYQQQIEMERLNHQA--------ELLLKKVTEESDK 3932

Query: 1827 ARLQRLEDELNRAKSTLEAETRVKQ-RLE------CEKQQIQNDLNQWKTQYSRKEEAIR 1879
              +Q    EL     +LE     +Q +LE       + Q   ++L  W T         +
Sbjct: 3933 HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQK 3992

Query: 1880 KIESEREKSERE---KNSLRSEIERLQAEIKRIEERCRRKLEDSTRE----TQSQLETER 1932
             +  + +  E E    + L++++   Q+ ++ + +     +E S  E     Q++LE   
Sbjct: 3993 PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLN 4052

Query: 1933 SRYQREIDKLRQRPY----------GSHRETQTECEWTVDTSK 1965
             R+Q  ++K  QR            G H E +   +W  DT +
Sbjct: 4053 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095



 Score = 82.0 bits (201), Expect = 8e-15
 Identities = 234/1345 (17%), Positives = 513/1345 (38%), Gaps = 173/1345 (12%)

Query: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 2139 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2198

Query: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 2199 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2253

Query: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991
                         ++VQ + +  A     YE   A+    L      P  R +++     
Sbjct: 2254 -------------QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAA 2300

Query: 992  ILQ-------EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK-------NTKIEVL 1037
            + Q       + +D      + + +S  Y   L  +   L DL  K       +T  + +
Sbjct: 2301 VTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAM 2360

Query: 1038 EEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLAS---LEELKRQAELDGKSAK 1094
             ++L  A+    E   + K     ++  QA C    A +       EL RQ E   KS K
Sbjct: 2361 NQQLETAQKMKQEIQQEKK----QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2416

Query: 1095 QNLDKCYGQIKELN---------EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA 1145
                K    ++ L          ++++R      D K+  ++       + +  + L K 
Sbjct: 2417 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2476

Query: 1146 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH---YNEE 1202
             +   + L  Q    EK I E E       +LL+ +G+ K   + +L  ++ +   +N++
Sbjct: 2477 HKDFSKTLTAQSHMYEKTIAEGE------NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2530

Query: 1203 MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKD--EIVRLNDSI 1260
            +    NK +  +        E +++ ++  + L   +D+      ++K   +     +SI
Sbjct: 2531 VKERENKLKESL--------EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI 2582

Query: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTI 1320
             +    ++  +++    +   +         EI+ + V    +++N    Q ++   + +
Sbjct: 2583 AKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV----TDENKSLIQKVDMVTEQL 2638

Query: 1321 QDKNKEIERLKAEFQE------EAKRRWEYENELSKVRNNYDEEIISLK--NQFETEINI 1372
              K   +E +  +F+E      E+KR+ +   E   + ++   +  S K     +T+   
Sbjct: 2639 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 2698

Query: 1373 TKTTIHQLTMQK------------EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTT 1420
             +   HQ+ + K             + TS    Q++ + +E+ +LS+++    + L    
Sbjct: 2699 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 2758

Query: 1421 ENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKN 1480
            + +   +  I+       E+  +  + + EL  +  +  +     KQ      +TI+   
Sbjct: 2759 QGIGHFQNTIR-------EMFSQFAEFDDELDSMAPVGRDAETLQKQK-----ETIKAFL 2806

Query: 1481 KEIERLKQLIDKETNDRKCL---EDENARLQRVQYDLQKANSSATETINKLKVQEQE--- 1534
            K++E L    D      K +   E+ +  L  ++ DL+  +    + +++ + +E++   
Sbjct: 2807 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 2866

Query: 1535 -LTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKK 1593
             + RL   Y ++ +E ++  Q     + S   + ++ + + ++LN  K    E+    + 
Sbjct: 2867 TIKRLEEFYSKL-KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 2925

Query: 1594 LEEELEGMRRSLKEQAIKITN---LTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRT 1650
             ++++  + + L + A K T+   L   L+  +   K     + Q+   L   L    R 
Sbjct: 2926 KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRF 2985

Query: 1651 QEELRRLSS------EVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIE 1704
            Q+ L  L S      E+ A ++    E + VK      +  Q+ ++D+  ++   K E E
Sbjct: 2986 QDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE 3045

Query: 1705 RLQSLTENLTK--------------EHLMLEEELRNLRLEYDDLRRGRSEADSDKNATIL 1750
            ++ +  E   K              E L+ + E RN +LE      G S      + T+ 
Sbjct: 3046 KIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLE------GISVVAQQFHETLE 3099

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE--SKNQCTQV 1808
             L   L     R +  + +     +  E + Q  +  +   +  +  + +  S  Q  +V
Sbjct: 3100 PLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH-KALEDDIINHNKHLHQAVSIGQSLKV 3158

Query: 1809 VQERE-----------SLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEK 1857
            +  RE           S +  I++ E+  +R + L+  L  AK   E E  +   L    
Sbjct: 3159 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL---- 3214

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
             ++ + L++   Q     E + K +SE    + +    +  ++  QA +  + E  ++  
Sbjct: 3215 NEVHDKLSKLSVQ-DYSTEGLWKQQSELRVLQEDILLRKQNVD--QALLNGL-ELLKQTT 3270

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTA 1977
             D     Q +LE  ++RY ++I KL      +  +          T + +   L K    
Sbjct: 3271 GDEVLIIQDKLEAIKARY-KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3329

Query: 1978 MQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA--------SASPKEKY 2029
            +  YE Q++      +     K +++ A   +  L     ++ A        +    EK 
Sbjct: 3330 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3389

Query: 2030 SLVEAKRKKLISPESTVMLLEAQAA 2054
               + +R +L+S   T  + E  AA
Sbjct: 3390 VAEDNERYRLVSDTITQKVEEIDAA 3414



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 187/966 (19%), Positives = 383/966 (39%), Gaps = 146/966 (15%)

Query: 996  AADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055
            A+ + A+  +L  R  +      E L  +E+LK K    E L E+L+   +  ++   + 
Sbjct: 1821 ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEV 1880

Query: 1056 KF-------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108
                     L Q +Q+  +E  + K  L  L  L ++    G  + + L      + E  
Sbjct: 1881 DVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL------VLEKT 1934

Query: 1109 EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA-IKEK 1167
              +++   E+ED  + +K       +Q + +  L K+ +       W K  ++K  I + 
Sbjct: 1935 NNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLK------SWIKETTKKVPIVQP 1988

Query: 1168 EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMS--NLRNKYETEINI--------- 1216
             +  E L   L++    + ++  +  +++   N  +S  NL +   T             
Sbjct: 1989 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2048

Query: 1217 ------TKTTIKEISMQKEDDSKNLRNQLDRLSRENRDL----KDEIVRLNDSILQATEQ 1266
                  T T  +E    K   S  ++  +  +S    DL    KD+I  LN  + +   Q
Sbjct: 2049 VLNGEGTATNTEEFWANKGLTS--IKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--Q 2104

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
            + + E +A+ Q       +QK      + +Q                 EA KT  ++NK 
Sbjct: 2105 KAQEESSAMMQW------LQKMNKTATKWQQTPAPTDT----------EAVKTQVEQNKS 2148

Query: 1327 IERLKAEFQEEAKRRWEYENELSKV-RNNYDEEIISLKNQFETEINITKTTIHQLTM--- 1382
             E   AE ++   +  E +++L+++   N D        Q  TEI+     ++QLT+   
Sbjct: 2149 FE---AELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2205

Query: 1383 QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQ 1442
            QK E++S    Q   +  + +    E + + + L   + +   +    QQ +    E + 
Sbjct: 2206 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFAT 2265

Query: 1443 RKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR--KCL 1500
            RK Q E    Q+T     + +  +   D + + I    +++  + Q  D  T     +C 
Sbjct: 2266 RKPQYE----QLTA--AGQGILSRPGEDPSLRGIV--KEQLAAVTQKWDSLTGQLSDRCD 2317

Query: 1501 EDENARLQRVQYD--LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
              + A ++  QY   L+  +   ++  NKL                VS      +Q +  
Sbjct: 2318 WIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA-----------VSTHPDAMNQQLET 2366

Query: 1559 FQNSLKELQLQKQKVE------EELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI 1612
             Q   +E+Q +K++++      E+L+ L +    +   + +L  +LEG+ +S K+   K 
Sbjct: 2367 AQKMKQEIQQEKKQIKVAQALCEDLSALVK----EEYLKAELSRQLEGILKSFKDVEQKA 2422

Query: 1613 TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQ 1672
             N  Q L+ A      S    +Q        L  K+  Q +   +S++++ L        
Sbjct: 2423 ENHVQHLQSACA----SSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVL-------- 2470

Query: 1673 ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYD 1732
            ES+ + H   + F K +  +S    ++  E E L   T+   K  L L+  L  ++  +D
Sbjct: 2471 ESLIKDH---KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--LNTIKTNWD 2525

Query: 1733 DLRRGRSEADSDKNATI---LELRSQLQISNNRTLELQGLINDLQ-----RERENLRQEI 1784
               +   E ++    ++   L+ + Q++       + Q  + +++      E EN   ++
Sbjct: 2526 TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKL 2585

Query: 1785 EKFQKQALEASNRIQESKNQCTQ-----------VVQERESLLVKIK-VLEQDKARLQRL 1832
            +  QK+  +    ++   N               V  E +SL+ K+  V EQ  ++   L
Sbjct: 2586 KSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 2645

Query: 1833 EDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIRKIESE 1884
            E+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++ ++ +
Sbjct: 2646 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 2705

Query: 1885 REKSER 1890
             + ++R
Sbjct: 2706 VDLAKR 2711



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 222/1228 (18%), Positives = 467/1228 (38%), Gaps = 188/1228 (15%)

Query: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF- 917
            ++  +   W   +KQ+  R   L++ +++   Y++  +    W+    + Q++LE +KF 
Sbjct: 2516 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI---DKCQNNLEEIKFC 2572

Query: 918  ----GDSNTVMRFLNEQKNLHSE---ISGKRDKSEEVQKIAELCANSIKDYELQLASYTS 970
                   N++ +  + QK +      +    + +  +  + E+    + D    L     
Sbjct: 2573 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2632

Query: 971  GLETLLNIPIKRTMIQSPSGVI--LQEAADVHARYIELLTRSGDYYRFLSEML---KSLE 1025
             +   L+   K+  +++ +      QE +    R ++      D +  L       K L 
Sbjct: 2633 MVTEQLH--SKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLT 2690

Query: 1026 DLKLKNTKIEVLEEEL----RLARDANSENCNKNKFLDQNL-------------QKYQAE 1068
             L+ +   ++ L+ ++    RLA+D   E  +     D  L             Q+   +
Sbjct: 2691 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 2750

Query: 1069 CSQFKAKLASL--------EELKRQAELD---------GKSAKQNLDKCYGQIKELNEKI 1111
            CS  + KL  +        E   + AE D         G+ A + L K    IK   +K+
Sbjct: 2751 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA-ETLQKQKETIKAFLKKL 2809

Query: 1112 TRLTYEIEDEKRRRKSVEDRFDQQ------KNDYDQLQKARQCEKENLGWQKLESE---- 1161
              L    ++  +  K +    +        K D + L K  QC K     Q  E +    
Sbjct: 2810 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSK--QCNKLLDRAQAREEQVEGT 2867

Query: 1162 -KAIKEKEYEIERLRVLLQEE----------GTRKREYENELAKVRNHYNEEMSNLRNKY 1210
             K ++E   +++   +LLQ+           G        +L   +    EE+  L+ K 
Sbjct: 2868 IKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ 2927

Query: 1211 ETEINITKTTIKEISMQKEDDSKNLRNQLD----RLSRENRDLKDEIVRLNDSILQATEQ 1266
            +    + +  I+  S  K   ++ L + LD    R    N+ +     +L +++L    +
Sbjct: 2928 QDVNWLGQGLIQ--SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC-GR 2984

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKE 1326
             + A E+ L       E++  ++    E K V  Q  E     ++ L++   T++   +E
Sbjct: 2985 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL-QRLLDDRKSTVEVIKRE 3043

Query: 1327 IERL--KAEFQEEAK---------RRWEYENELSKVRNNYDEEIISLKNQFE---TEINI 1372
             E++   AE  ++ K          RWE     ++ RN   E I  +  QF      +N 
Sbjct: 3044 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3103

Query: 1373 TKTTIHQLTM----------QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTEN 1422
              TTI +  +          + EE  + ++A  D++   N+ L + +     ++ Q+ + 
Sbjct: 3104 WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAV-----SIGQSLKV 3158

Query: 1423 L-RRVEEDIQQQKATGSEV----SQRKQQLEVELRQV----TQMRTEESVRYKQSLDDAA 1473
            L  R ++D+ Q K   S+V     Q K     EL Q      ++  E+ V     L++  
Sbjct: 3159 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3218

Query: 1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATET--------- 1524
              +   + +    + L  +++  R   ED   R Q V   L        +T         
Sbjct: 3219 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3278

Query: 1525 --INKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLK- 1581
              +  +K + +++T+L  D  +  ++     Q   R  ++ +EL     KVE EL   + 
Sbjct: 3279 DKLEAIKARYKDITKLSTDVAKTLEQAL---QLARRLHSTHEELCTWLDKVEVELLSYET 3335

Query: 1582 -----RTASEDSCKRKKLEEELEGMRR---SLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
                   AS+   + K+L++E +  +    SL E +  +  L     +  + K  +ED+ 
Sbjct: 3336 QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN- 3394

Query: 1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693
                               E  RL S+       + Q+ E +  A LR++ F +A + + 
Sbjct: 3395 -------------------ERYRLVSDT------ITQKVEEIDAAILRSQQFDQAADAEL 3429

Query: 1694 RSLNESKIEIERLQS--LTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD-KNATIL 1750
              + E++ ++  L    L ++ T   L +++      L + D+     ++      A   
Sbjct: 3430 SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSE 3489

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ 1810
            E +  ++   ++ L+    I  +  ER    +  +    Q  E    +     +   ++ 
Sbjct: 3490 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 3549

Query: 1811 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV-KQRLEC---EKQQIQNDLNQ 1866
            +  +  ++ + L Q +   ++L + +   K  ++   +   Q LE    E   IQ     
Sbjct: 3550 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVA 3609

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR---------KL 1917
              T YS+ +E ++K     +++  +      +I+++   ++RI ER R+         K+
Sbjct: 3610 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKI 3669

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            ++   E ++ +  +  + Q   + L+QR
Sbjct: 3670 KEQISENKN-VSVDMEKLQPLYETLKQR 3696



 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 210/1176 (17%), Positives = 463/1176 (39%), Gaps = 157/1176 (13%)

Query: 858  EKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            +K+  +  R++ I K        LE+ ++  R     ++  C WL   +    S E+   
Sbjct: 3279 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYET--- 3335

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA-NSIKDYELQLASYTS--GLET 974
                   + L  ++   +++  K  K E     A L + N +    L+L  + +  GLE 
Sbjct: 3336 -------QVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3388

Query: 975  LLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKI 1034
            ++    +R  + S +  I Q+  ++ A  +    RS  + +     L  + + + K   +
Sbjct: 3389 MVAEDNERYRLVSDT--ITQKVEEIDAAIL----RSQQFDQAADAELSWITETEKKLMSL 3442

Query: 1035 EVLEEELRLARDANSENCNKNKFLDQNLQKYQAEC-----SQFKAKLASLEELKRQAELD 1089
                 ++RL +D  S      K     + +++        S  K   A  EE K+     
Sbjct: 3443 G----DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ----- 3493

Query: 1090 GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
              S K+ LDK    + +  + I ++  E   +  R +S+ ++F +   +        Q  
Sbjct: 3494 --SMKKKLDK----VLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI 3547

Query: 1150 KENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
               L    LE E  +++++ E  +LR L+ E      +      ++      E  +++ K
Sbjct: 3548 ISQLPAPALEYE-TLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEK 3606

Query: 1210 YETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR 1269
            Y             +  Q ++D K     LD    ++    D+I ++ +S+ +  E+ R+
Sbjct: 3607 Y--------VAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3658

Query: 1270 AEENALQQKACGSEIMQKKQ-HLEIE----LKQVMQQRSEDNARHKQSLEE--AAKTIQD 1322
                + + +    +I + K   +++E    L + ++QR E+        ++  +AK +QD
Sbjct: 3659 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 3718

Query: 1323 KNKEI----ERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH 1378
            K  ++    E +    +E   +  +      K   ++   I+++K+  +   ++    I 
Sbjct: 3719 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 3778

Query: 1379 -QLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATG 1437
              +  Q++E     R +ID L  E   +      L     +  + +  V++ I +  +  
Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 3836

Query: 1438 SEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD------DAA----KTIQDKNKEIERLK 1487
              +++  +    +L +  Q     +V+Y+  L       D A     ++     ++E +K
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQA----AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 3892

Query: 1488 QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547
            Q I++    +     +   ++R+ +  +      TE  +K  VQ+  L  L++ ++ + +
Sbjct: 3893 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP-LMELKLIWDSL-E 3950

Query: 1548 ERTVKDQD--------ITRFQNSLKELQ---------LQKQK--------VEEELNRLKR 1582
            ER +  Q         + +FQ++L EL          L +QK        +E EL +   
Sbjct: 3951 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAK-HH 4009

Query: 1583 TASEDSCKRKKLEEELEGMRRSLKEQAI--KITNLTQQLEQASIVKKRSEDDLRQQRDVL 1640
                D    +   E +      L E +   + +NL  +LE  +   +   +   Q++  L
Sbjct: 4010 VLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4069

Query: 1641 DGHLREKQRTQEELRRLSSEVEALRRQLLQEQ------ESVKQAHLRNEHFQKAIEDKSR 1694
            DG LR+ +    E+  L   +    R LL  +      E+ K+    N H +     +++
Sbjct: 4070 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ--LNVHMEVCAAFEAK 4127

Query: 1695 SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATI---LE 1751
                  +  +  Q L          +++++ NL+ +++ +    +E  +     +   +E
Sbjct: 4128 EETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAME 4187

Query: 1752 LRSQLQISNNRTLELQGLINDLQR-------------ERENLRQEIEKFQKQALEASNRI 1798
              + LQ   N   + +  +N   R             E +    E+   ++Q +E     
Sbjct: 4188 FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTG 4247

Query: 1799 QESK--NQCTQVVQERESLLVKI-----KVLEQDKARLQRLEDELNRAKSTLEAETRVKQ 1851
               K  +Q   VV  + +LL+ +     KV+++   R + L+D   RAK   EA +++ +
Sbjct: 4248 THLKYFSQKQDVVLIK-NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4306

Query: 1852 RLECEKQ------QIQNDLNQWKTQYSRKEEAIRKIESERE---------KSEREKNSLR 1896
             LE  ++      +I ND ++ KTQ ++ +E  + + ++           +S +EK SL 
Sbjct: 4307 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4366

Query: 1897 SEIERLQAEIKRIEER----CRRKLEDSTRETQSQL 1928
             +  +L   +  + ++    C + +E   +  ++ L
Sbjct: 4367 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4402



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 186/959 (19%), Positives = 361/959 (37%), Gaps = 164/959 (17%)

Query: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 3641 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700

Query: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 3701 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 3760

Query: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 3761 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 3811

Query: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 3812 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 3864

Query: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 3865 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 3923

Query: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 3924 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 3977

Query: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 3978 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4036

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 4037 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4093

Query: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 4094 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4153

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK-- 1218
            ++ I   + + E +   L E  T+  E  N LA   ++  ++  N   + E  +N+    
Sbjct: 4154 DQDINNLKEKWESVETKLNERKTKLEEALN-LAMEFHNSLQDFINWLTQAEQTLNVASRP 4212

Query: 1219 -----TTIKEISMQK--EDDSKNLRNQLDRLSRENRDL-----KDEIVRLN--------- 1257
                 T + +I   K   ++  + R Q+  L +    L     K ++V +          
Sbjct: 4213 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4272

Query: 1258 -DSILQATEQRRR----AEENALQQKACGSEIM------QKKQHLEIELKQVMQQRSEDN 1306
             + ++Q   +R R    A + A Q     S++M      +K    E+E+     +     
Sbjct: 4273 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4332

Query: 1307 ARHKQSLEE--AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD-------- 1356
            A+HK+  +   A  ++ D      R   E    A    + ++ LS++R+ +D        
Sbjct: 4333 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4392

Query: 1357 -----EEIISLKNQFETEINITKTTIHQLTMQKEED--TSGYRAQIDNLTRENRSLSEEI 1409
                 EE +    QF   +      ++++  Q  ED    G    + NL   +++  +E+
Sbjct: 4393 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4452

Query: 1410 KRLKNTLTQTTENLRRV----EEDIQQQKATGSEVSQR-----------KQQLEVELRQV 1454
             +  +++     + R +     +D    K    E+S R           + +LE  LRQ 
Sbjct: 4453 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4512

Query: 1455 TQMRT------------EESVRYKQSL---DDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
             +  +            E+++R+   L   +DA +T+ D++KE   +K+L +K     K
Sbjct: 4513 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF--MKKLEEKRAELNK 4569



 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 193/1127 (17%), Positives = 438/1127 (38%), Gaps = 186/1127 (16%)

Query: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 3859 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 3917

Query: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 3918 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 3949

Query: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 3950 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4001

Query: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4061

Query: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 4062 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4108

Query: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 4109 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4162

Query: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 4163 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4221

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 4222 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4269

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 4270 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4323

Query: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105
            D +             ++   A+  +F+  L +   +       G+S K+        + 
Sbjct: 4324 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT-----SLA 4366

Query: 1106 ELNEKITRLTYEIED--EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA 1163
            + N K+  +  E+ D  +    KSVE +        ++L++A          Q  ++ +A
Sbjct: 4367 DDNLKLDDMLSELRDKWDTICGKSVERQ--------NKLEEALL-----FSGQFTDALQA 4413

Query: 1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH--YNEEMSNLRNKYETEINITKTTI 1221
            + +  Y +E     L E+     + +  +  + NH  + +E+     K  + +   K + 
Sbjct: 4414 LIDWLYRVE---PQLAEDQPVHGDIDLVMNLIDNHKAFQKEL----GKRTSSVQALKRSA 4466

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
            +E+     DDS  ++ Q+  LS              +++   +  ++   E AL+Q    
Sbjct: 4467 RELIEGSRDDSSWVKVQMQELSTR-----------WETVCALSISKQTRLEAALRQ---- 4511

Query: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
            +E      H  +E     +Q    +       E+A +T+ D++KE  +   E + E  + 
Sbjct: 4512 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRTLIDQHKEFMKKLEEKRAELNKA 4570

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE 1401
                + +  +   + + I ++K+     I I +    ++    ++      + +  L  +
Sbjct: 4571 TTMGDTVLAI--CHPDSITTIKHW----ITIIRARFEEVLAWAKQHQQRLASALAGLIAK 4624

Query: 1402 NRSLSEEIKRLKNTLTQTTENLRRV-EEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTE 1460
               L   +  L+   T  T+  + V  ++I++ KA  +E                Q   E
Sbjct: 4625 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE---------------HQTFME 4669

Query: 1461 ESVRYKQSLDDAAKTIQDKNKEIERLKQ---LIDKETNDRKCLEDENARLQRVQYDLQKA 1517
            E  R +  +D   KT + +  +   L+    ++DK    RK     +      Q  ++  
Sbjct: 4670 EMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETK 4729

Query: 1518 NSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEEL 1577
            N      +N L  + Q++  L ++  R   +   + +++  F N   +  + ++K    +
Sbjct: 4730 N----PRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF--DFDIWRKKYMRWM 4783

Query: 1578 NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624
            N  K++   D  +R   +++ +  R+   +  +     T +LE +++
Sbjct: 4784 NH-KKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAV 4829



 Score = 43.1 bits (100), Expect = 0.004
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 4424 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4481

Query: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541

Query: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 4542 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4598

Query: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 4599 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 4655

Query: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 4656 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 4715

Query: 474  KIVHKGDECILKDNNER-----SKW 493
             +   G +  ++  N R     SKW
Sbjct: 4716 SLYPSGSQTQIETKNPRVNLLVSKW 4740



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 2822 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2849
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 5084 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5111



 Score = 35.4 bits (80), Expect = 0.82
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 2825 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2851
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 5091 SRPGSRAGSKAGSRASSRRGSDASDFD 5117



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 2798 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2841
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 5069 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5111


>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score =  561 bits (1447), Expect = e-159
 Identities = 308/992 (31%), Positives = 548/992 (55%), Gaps = 69/992 (6%)

Query: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 726

Query: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 727  -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 785

Query: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 786  LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 845

Query: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 846  KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 905

Query: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 906  LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 965

Query: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 966  LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1025

Query: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 1026 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1085

Query: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052
            T    Y +F  + LK L  E+  L+  K E +E             + L+ A  A     
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145

Query: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103
            +K K   + +   + + S+       F AK      +E + + E   K+ +++ +  + +
Sbjct: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205

Query: 1104 -IKELNEKITRLTYEIEDEKRRRKSVEDRFDQ 1134
             +K+L E  T  + +++ E++  K +    DQ
Sbjct: 1206 SLKQLQESQT--SGDVKVEEKLDKVIAGTIDQ 1235



 Score =  160 bits (404), Expect = 2e-38
 Identities = 262/1346 (19%), Positives = 539/1346 (40%), Gaps = 163/1346 (12%)

Query: 1185 KREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKE------DDSKNLRNQ 1238
            + E+ ++L  V +H     +  R   E E ++ +  I EI M         +    L +Q
Sbjct: 298  RTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQ 357

Query: 1239 LDRLSRENRDLKDEIVRLNDSILQATEQ-----RRRAEENALQQKACGSEIMQKKQHLEI 1293
              +L   +R+ +  +  L++ + +AT +      +  EE A       + I +KK +   
Sbjct: 358  YAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDY-HA 416

Query: 1294 ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353
            EL + + Q+ E+     +S++E A+ +  +N         ++   + +W +  +L +   
Sbjct: 417  ELMRELDQKEENI----KSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 472

Query: 1354 NYDEE---IISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIK 1410
             + +E        N  +   +  +     +  +   D S    ++++L +E+    EE+ 
Sbjct: 473  QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 532

Query: 1411 RLKNTLTQTTENLRRVEEDIQQQKATGSEVSQR-----KQQLEVELRQVTQMRTEESVRY 1465
            + K+T+     NL    + I Q K   S+   +     K   +    ++T  + +E V  
Sbjct: 533  QYKSTIA----NLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLA 588

Query: 1466 KQS----------------LDDAAKTIQDKNKEIERLKQLIDKETNDRKCL-EDENARLQ 1508
              S                +     T+   NKE   L   I+++  +   L  + +  ++
Sbjct: 589  NNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMK 648

Query: 1509 RV---QYDLQKANSSATETINKLKVQ-----EQELTRLRIDYERV---SQERTV-KDQDI 1556
             V    Y + + +      +  +K       +Q L+ L+  +E     SQE  V    DI
Sbjct: 649  SVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDI 708

Query: 1557 TRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKI---- 1612
            T+ +   KE+ + KQ  +E L   +R   E+S     + E +  +R  L+    ++    
Sbjct: 709  TQLE---KEVNVCKQYYQELLKSAEREEQEESVYNLYISE-VRNIRLRLENCEDRLIRQI 764

Query: 1613 -TNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEEL---RRLSSEVEALRRQL 1668
             T L +     S+ +   ++ L+++ + L   L       EE       SS V  LR +L
Sbjct: 765  RTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824

Query: 1669 LQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLR 1728
                +++ Q +  +  +   ++  +  L  ++   E L  L E    E   +  +  N+ 
Sbjct: 825  NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA-EALVKLYETKLCEEEAVIADKNNIE 883

Query: 1729 LEYDDLRRGRSEADSDK---NATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIE 1785
                 L++ RSE D  +   +A   EL+    IS+      +    D    +E   Q +E
Sbjct: 884  NLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE 943

Query: 1786 KFQKQALEASNRIQESKNQCTQVVQERESL-----------LVKIKVLEQDKARLQRLED 1834
            ++Q   ++  NR+++ +     +   R++              + K+ E      + L  
Sbjct: 944  RWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLAT 1003

Query: 1835 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1894
            +LN+ K  L +E  +KQ    E Q+     +     Y  +    R +   ++KS  ++  
Sbjct: 1004 QLNQQKM-LVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRR 1062

Query: 1895 LRSEIERLQAE-------------------------IKRIEERCRRKLEDSTRETQSQLE 1929
            ++S  + +  E                         +KR+EE  +   E+     +   E
Sbjct: 1063 MQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKE 1122

Query: 1930 TER-----SRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQ 1984
             ++     S+  ++ +K  + P+   + +  E    + T K   + L + +  +QL+  +
Sbjct: 1123 LQKWVSNISKTLKDAEKAGKPPFSKQKISSEE----ISTKK---EQLSEALQTIQLFLAK 1175

Query: 1985 LIDKTT---LDKLLKGKKSVEE----VASEIQPFLRGAGSIAGASASPK----------- 2026
              DK T    ++L K  K+++E    + SE    L+ + +        K           
Sbjct: 1176 HGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQ 1235

Query: 2027 ---EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083
               E  S+ +A  + LI  ++ + LLE Q    G+I P   +   +  A +  LID    
Sbjct: 1236 TTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQIL 1295

Query: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143
             Q+    KA        S  T+ V +A+ +++I     +++LE  +++G +V P     L
Sbjct: 1296 CQLKELSKA-KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQL 1354

Query: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV 2203
                A  + L+   L+  + + ++  K+ +DP T +KVS + + +R  ++ +TG+ LL V
Sbjct: 1355 TLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPV 1414

Query: 2204 QKRSMSFQGIR--QPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA 2261
            + +      ++  + +++      G++   T+  L S Q+            L G     
Sbjct: 1415 RPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQL------------LSG----- 1457

Query: 2262 GIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLV 2321
            G+ N  + Q++ + EA++ G++   TA  +L  Q  TG I+      RL V+EA +  L+
Sbjct: 1458 GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLI 1517

Query: 2322 GIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPK 2381
                   +L A+R   G   P +G I     ++ +ELI      ++L  +     +  P+
Sbjct: 1518 TSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPE 1577

Query: 2382 ESHRLPVDIAYKRGYFNEELSEILSD 2407
             S  + +D A + G  +   + IL +
Sbjct: 1578 SSQVIGLDAAKQLGIIDNNTASILKN 1603



 Score =  118 bits (295), Expect = 1e-25
 Identities = 282/1490 (18%), Positives = 570/1490 (38%), Gaps = 189/1490 (12%)

Query: 909  QDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKI--AELCANSIKDYELQLA 966
            + SL      +    M+F+ +  N   E+  + D++E    +   E    + K+    + 
Sbjct: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 323

Query: 967  SYTSGLETLLNIPIKRTMIQSPSGVILQEAADVH---ARYIELLTRSGDYYRFLSEMLKS 1023
             + S L+       K + IQ  + + L  A  +H   ++Y +LL  S +  R L  +   
Sbjct: 324  EFESSLKEA-----KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNF 378

Query: 1024 LEDLKLKNTKIEVLE-EELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEEL 1082
            +   +  N  I + E EE  +A D +  N N  +  D + +  + E  Q +  + S++E+
Sbjct: 379  VS--RATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMR-ELDQKEENIKSVQEI 435

Query: 1083 KRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL 1142
              Q  L+   A+  ++     ++     I +L   +E   +   +  + F+  K   D L
Sbjct: 436  AEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL 495

Query: 1143 QKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEE 1202
            +  +   +      +  S          I +L  L+QE    K E           Y   
Sbjct: 496  RNLKDAIQRKYSCDRSSS----------IHKLEDLVQESMEEKEELLQ--------YKST 537

Query: 1203 MSNLRNKYETEINIT--------KTTIK----------EISMQKEDDSKNLRNQ------ 1238
            ++NL  K +T I +         KT+I           EI++ K+D+     N       
Sbjct: 538  IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWK 597

Query: 1239 -----------------LDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQ----- 1276
                             +   ++E  DL + I +   ++L    +     ++ +      
Sbjct: 598  VISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLI 657

Query: 1277 ---QKACGSEIMQKKQHLEIELKQVM---QQRSEDNARHKQSLEE-AAKTIQDKNKEIER 1329
                +   S +   K  L  E +QV+   Q R ED     Q  +  +   I    KE+  
Sbjct: 658  NEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNV 717

Query: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
             K  +QE  K   E E +   V N Y  E+ +++ + E   N     I Q+    E D  
Sbjct: 718  CKQYYQELLKSA-EREEQEESVYNLYISEVRNIRLRLE---NCEDRLIRQIRTPLERDD- 772

Query: 1390 GYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEV 1449
                 +  +T E   L +E++RLK+ L   T       E+   Q A  S V   + +L V
Sbjct: 773  -LHESVFRIT-EQEKLKKELERLKDDLGTITNKC----EEFFSQAAASSSVPTLRSELNV 826

Query: 1450 ELRQVTQMRTEESVRYKQSLDDAAKTIQ---DKNKEIERLKQLIDKETNDRKCLEDENAR 1506
             L+ + Q+ +  S        D  KT+       +  E L +L + +  + + +  +   
Sbjct: 827  VLQNMNQVYSMSSTYI-----DKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNN 881

Query: 1507 LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKEL 1566
            ++ +   L++  S   E        E EL + +   + + +    +D D    +    +L
Sbjct: 882  IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941

Query: 1567 QLQKQKVEEEL-NRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIV 1625
              + Q V  ++ NRL+               +LEG+ +SLK        L   ++Q    
Sbjct: 942  VERWQNVHVQIDNRLR---------------DLEGIGKSLKYYRDTYHPLDDWIQQVETT 986

Query: 1626 KKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHF 1685
            +++ +++  +    L   L +++    E+    S+++  ++   Q   +VK   L+   +
Sbjct: 987  QRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTY 1046

Query: 1686 QKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEE---LRNLRLEY-----DDLRRG 1737
            +  ++ + +S     ++  R+QS  + + +E + L      L  L  +Y     D L+R 
Sbjct: 1047 RAMVDSQQKS----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRL 1102

Query: 1738 RSEADS--DKNATILELRSQLQ--ISN-NRTLELQGLINDLQRERENLR-QEIEKFQKQA 1791
              E  S  ++    +E   +LQ  +SN ++TL+           ++ +  +EI   ++Q 
Sbjct: 1103 EEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQL 1162

Query: 1792 LEASNRIQE--SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV 1849
             EA   IQ   +K+      +ER  L  ++K L Q+   L   E      +S    + +V
Sbjct: 1163 SEALQTIQLFLAKHGDKMTDEERNELEKQVKTL-QESYNLLFSESLKQLQESQTSGDVKV 1221

Query: 1850 KQRLECEKQQIQNDLNQWKTQYSRKEEA-----------IRKIESEREKSEREKNSLRSE 1898
            +++L+   + I   ++Q   +     +A           IR +E++   S      LR  
Sbjct: 1222 EEKLD---KVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKC 1278

Query: 1899 IERLQAEIKR-IEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTEC 1957
             +   A+    I+E+   +L++ ++  +  +          +D L Q         +   
Sbjct: 1279 FDLKDAKSHGLIDEQILCQLKELSKAKEI-ISAASPTTIPVLDALAQSMITESMAIKV-L 1336

Query: 1958 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEI--------- 2008
            E  + T  LV     +++T  + ++  L+      K+L+ +   +++             
Sbjct: 1337 EILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLID 1396

Query: 2009 ---QPFLRGAGSIAGASASPKE----------KYSLVEAKRKKLISPESTVMLLEAQAAT 2055
               +  L+    +      P+E            S++ A  + LI  E+   LL AQ  +
Sbjct: 1397 MVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFRLLSAQLLS 1456

Query: 2056 GGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNL 2115
            GG+I+ +  +++TV+ A+   +ID D    I   +    G       K ++V EA++ +L
Sbjct: 1457 GGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDL 1516

Query: 2116 IDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDP 2175
            I   + + +LEAQ    G++ P +    P   +L + LI  +L   + + R        P
Sbjct: 1517 ITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIP 1576

Query: 2176 VTKKKVSYVQLKERCRIEPHTGLLL--LSVQKRSMSFQGIRQPVTVTELVDSGILRPSTV 2233
             + + +     K+   I+ +T  +L  +++  +      +         +     +PSTV
Sbjct: 1577 ESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACKNARRWLSFCKFQPSTV 1636

Query: 2234 NELESGQISYD-------EVGERIKDFLQGSSCIAGIYNETTKQKLGIYE 2276
            ++    +  +D       +  E  K        I    +  T Q+L +Y+
Sbjct: 1637 HDYRQEEDVFDGEEPVTTQTSEETKKLFLSYLMINSYMDANTGQRLLLYD 1686



 Score =  111 bits (278), Expect = 9e-24
 Identities = 275/1424 (19%), Positives = 574/1424 (40%), Gaps = 215/1424 (15%)

Query: 1309 HKQSLEEAAKTIQDKNKEIERLK-AEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQ-- 1365
            H ++ +   + I++    ++  K +E Q  A  +  Y  +L ++ + Y + + + +NQ  
Sbjct: 311  HLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQER 370

Query: 1366 -FETEINITKTTIHQLTM--QKEEDTSGY--RAQIDNLTRENRSLSEEIKRLKNTLTQTT 1420
              +T  N      ++L    +KEE+   Y    +  N+ R+    +E    L   L Q  
Sbjct: 371  HLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE----LMRELDQKE 426

Query: 1421 ENLRRVEEDIQQ------------------QKATGSEVSQRKQQLEVELRQVTQM----- 1457
            EN++ V+E  +Q                   +   S + Q  Q +E  +++ T       
Sbjct: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486

Query: 1458 RTEESVRYKQSLDDAA--KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQ 1515
              +E+  Y ++L DA   K   D++  I +L+ L+ +   +++ L         +QY   
Sbjct: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL---------LQYKST 537

Query: 1516 KAN-SSATETINKLKVQEQELT-RLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKV 1573
             AN     +TI +LK +  +   +  I  + +   R +   +IT +++   E  L     
Sbjct: 538  IANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQI---EITIYKDD--ECVLANNSH 592

Query: 1574 EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDL 1633
              +   +  T +E       +   +        ++A+ + N  +Q  Q +++    E  +
Sbjct: 593  RAKWKVISPTGNE------AMVPSVCFTVPPPNKEAVDLANRIEQQYQ-NVLTLWHESHI 645

Query: 1634 RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKS 1693
              +  V   +L       E  R  +S V +++  L  E + V  ++L++  F+  +ED  
Sbjct: 646  NMKSVVSWHYL-----INEIDRIRASNVASIKTMLPGEHQQVL-SNLQSR-FEDFLEDSQ 698

Query: 1694 RS-------LNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN 1746
             S       + + + E+   +   + L K     E+E     L   ++R  R   ++ ++
Sbjct: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCED 758

Query: 1747 ATILELRSQLQISNNRTLELQGLINDLQR--ERENLRQEIEKFQKQALEASNRIQESKNQ 1804
              I ++R+ L        E   L   + R  E+E L++E+E+ +      +N+ +E  +Q
Sbjct: 759  RLIRQIRTPL--------ERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ 810

Query: 1805 C---TQVVQERESLLVKIKVLEQDKARLQRLEDELNRA----KSTLEAETRVK--QRLEC 1855
                + V   R  L V ++ + Q  +      D+L       K+T  AE  VK  +   C
Sbjct: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLC 870

Query: 1856 EKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRR 1915
            E++ +  D N  +   S     +++  SE ++  +  ++L  E+++ +A           
Sbjct: 871  EEEAVIADKNNIENLIS----TLKQWRSEVDEKRQVFHALEDELQKAKA----------- 915

Query: 1916 KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975
             + D   +T  + + +   ++ + D+L +R    H +        +D      +G+ K  
Sbjct: 916  -ISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ--------IDNRLRDLEGIGK-- 964

Query: 1976 TAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAK 2035
             +++ Y         LD  ++  ++ +    E QP    + ++A      K   S +E K
Sbjct: 965  -SLKYYRDTY---HPLDDWIQQVETTQRKIQENQP--ENSKTLATQLNQQKMLVSEIEMK 1018

Query: 2036 RKKLISPE-------STVMLLEAQAAT-GGIIDPHRN---EKLTVDSAIARDLIDFDDRQ 2084
            + K+   +       +TV   E Q  T   ++D  +    ++  + S+    + +F D +
Sbjct: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1078

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
              Y A   +      F+G ++   E  +K+L + +                     V   
Sbjct: 1079 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK------------------EHVEKA 1120

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQL---KERCRIEPHTGLLLL 2201
            K++      I + L       +D++K    P +K+K+S  ++   KE+      T  L L
Sbjct: 1121 KELQKWVSNISKTL-------KDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173

Query: 2202 SVQKRSMSFQGIRQ-PVTVTELVDS-GILRPSTVNELESGQISYDEVGERIKDFLQGSSC 2259
            +     M+ +   +    V  L +S  +L   ++ +L+  Q S D   E   D       
Sbjct: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLD-----KV 1228

Query: 2260 IAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRG 2319
            IAG  ++TT + L +++A+  GL+   T + LLE Q     ++ P       +++A   G
Sbjct: 1229 IAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHG 1288

Query: 2320 LVGIEF--KEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGI 2377
            L+  +   + K LS  + +     P T   I +  A+ + +I +   I++LE  ++TG +
Sbjct: 1289 LIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGSL 1345

Query: 2378 IDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDE 2437
            + P    +L +  A+++   +  L   + +  +  K   DP T E ++ + + +R    E
Sbjct: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405

Query: 2438 ETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELC 2497
             TG+ LLP++      Q   + TL+            + +S+  A  +GLID ET   L 
Sbjct: 1406 NTGMWLLPVRP-----QEGGRITLK----------CGRNISILRAAHEGLIDRETMFRLL 1450

Query: 2498 EQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFD-----QYRSGSL 2552
              +       ++G        L++  +G +  +++A+ +G++DR         Q ++G +
Sbjct: 1451 SAQL------LSGG-------LINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGI 1497

Query: 2553 SLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH------ESVSKISTISSVRNLTIRS 2606
              +  A  +++   V       S     + +   +       S     T SS++   I +
Sbjct: 1498 IQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITN 1557

Query: 2607 SSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRL 2650
                  L     IAA++  E+ + I +    + GI+D+ T   L
Sbjct: 1558 ELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601



 Score = 92.4 bits (228), Expect = 6e-18
 Identities = 97/390 (24%), Positives = 164/390 (42%), Gaps = 54/390 (13%)

Query: 2399 EELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQ- 2457
            E+LSE L           D  T+E    L+ + + +++       L   E  KQ+Q SQ 
Sbjct: 1160 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN----LLFSESLKQLQESQT 1215

Query: 2458 ------KNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGS 2511
                  +  L K     +D  T + +SV +A  +GLIDY+T   L E +     + I+G 
Sbjct: 1216 SGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ-----LMISG- 1269

Query: 2512 DGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSS 2571
                   L+  +    +D++DA   GL+D +           L Q  ++   K  +  +S
Sbjct: 1270 -------LISPELRKCFDLKDAKSHGLIDEQI----------LCQLKELSKAKEIISAAS 1312

Query: 2572 SMGSGVSDDVFSSSRHESVS------KISTISSVRNLT--------------IRSSSFSD 2611
                 V D +  S   ES++       +ST S V   T              + S+ FS 
Sbjct: 1313 PTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSK 1372

Query: 2612 TLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSL 2671
             LE  +    + D    EK+S+ + ++R  +   TG  LL  +   GG I    G+ +S+
Sbjct: 1373 VLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISI 1432

Query: 2672 QDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQY 2731
              A  +G+ID++   RL  AQ    G       ++M+  EAV+E  +  +     L +Q 
Sbjct: 1433 LRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492

Query: 2732 LTGGLVDPEVHGRISTEEAIRKGFIDGRAA 2761
             TGG++      R++ +EA++   I   +A
Sbjct: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSA 1522



 Score = 83.6 bits (205), Expect = 3e-15
 Identities = 93/458 (20%), Positives = 190/458 (41%), Gaps = 67/458 (14%)

Query: 2312 VEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQ 2371
            ++E+   G V +E  EKL   ++ + G  D  TG ++S+FQA+ + LI+   GIRLLE Q
Sbjct: 1210 LQESQTSGDVKVE--EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQ 1264

Query: 2372 IATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKE 2431
            +   G+I P+      +  A   G  +E++   L + S   K      +   +  L    
Sbjct: 1265 LMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSK-AKEIISAASPTTIPVLDALA 1323

Query: 2432 RCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYE 2491
            + +  E   + +L +      + T            +V P T +++++Q+A+++ L+   
Sbjct: 1324 QSMITESMAIKVLEIL-----LSTGS----------LVIPATGEQLTLQKAFQQNLVSSA 1368

Query: 2492 TFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGS 2551
             F ++ E++   ++             L+D  T  +  + D + +  +      Q  +G 
Sbjct: 1369 LFSKVLERQNMCKD-------------LIDPCTSEKVSLIDMVQRSTL------QENTGM 1409

Query: 2552 LSLT---QFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSS 2608
              L    Q    I+LK G   S              + HE +    T+  + +  + S  
Sbjct: 1410 WLLPVRPQEGGRITLKCGRNIS-----------ILRAAHEGLIDRETMFRLLSAQLLSGG 1458

Query: 2609 FSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2668
                         + ++ + +++++ E +  G++D  T   +L  Q  TGGII     ++
Sbjct: 1459 -------------LINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKR 1505

Query: 2669 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2728
            L++ +AV   +I    A  +  AQ+ ++G       +    + +++++ +  E   + L 
Sbjct: 1506 LTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILN 1565

Query: 2729 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQD 2766
             +     L  PE    I  + A + G ID   A  L++
Sbjct: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKN 1603



 Score = 80.9 bits (198), Expect = 2e-14
 Identities = 65/246 (26%), Positives = 109/246 (44%), Gaps = 32/246 (13%)

Query: 2579 DDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSP-------------IAAIFDT 2625
            D +    R+E   ++ T+    NL    S     L+ES               IA   D 
Sbjct: 1178 DKMTDEERNELEKQVKTLQESYNLLFSESL--KQLQESQTSGDVKVEEKLDKVIAGTIDQ 1235

Query: 2626 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685
               E +S+ + + RG++D  TG RLLE Q    G+I P   +   L+DA S G+ID+ + 
Sbjct: 1236 TTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQIL 1295

Query: 2686 TRLKPAQKAFIGFEGVKGKKKMSAA--------EAVKEKWLPYEAGQRFLEFQYLTGGLV 2737
             +LK   KA         K+ +SAA        +A+ +  +      + LE    TG LV
Sbjct: 1296 CQLKELSKA---------KEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLV 1346

Query: 2738 DPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDI 2797
             P    +++ ++A ++  +      ++ +  +  K L  P T  K+S  D + RS +++ 
Sbjct: 1347 IPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQEN 1406

Query: 2798 TGLRLL 2803
            TG+ LL
Sbjct: 1407 TGMWLL 1412


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  557 bits (1435), Expect = e-158
 Identities = 451/1830 (24%), Positives = 861/1830 (47%), Gaps = 177/1830 (9%)

Query: 178  SGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDY------ 231
            S  DE       E L W+ + + +++   WG DL SVE  + + + IH S+ +       
Sbjct: 579  SSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKE 638

Query: 232  -RWQLDKIKADLREKSA--IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIND 288
             R    K+  +     A  + +LE +Y  L + S  RM HL+ L   +   + E++W+N+
Sbjct: 639  ARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNE 698

Query: 289  CEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIE 348
             EEEEL YDWSD N+NI+ K+  FS    +LE K+     L+  ++ L L  HPA   +E
Sbjct: 699  KEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVE 758

Query: 349  AYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKN 408
            AY   +Q+Q  W+ Q+  C++ H+KEN AYFQFF +A+  E++L+ LQDSI++KY CD N
Sbjct: 759  AYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHN 818

Query: 409  MPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCD 468
              L  L + +++   E+E++++ K  V +LV +SK IVQLKPR+PD+     I ++A+CD
Sbjct: 819  TSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCD 878

Query: 469  YKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQ 528
            Y+Q +  + K DEC+L+DN++R+KW V  P G + +VPSV  +IPPPN  A++++ ++EQ
Sbjct: 879  YRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQ 938

Query: 529  YYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQ 588
             Y+ ++ALW+QL++N KSL+SW+Y   D++ ++   + KL++    +  + + +L+ HY+
Sbjct: 939  SYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998

Query: 589  EFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQD 648
            +F+++S+ S +F   D+ +++ +    +  +Q L+  +    + +TV    I+       
Sbjct: 999  DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYIS------- 1051

Query: 649  VNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLA----DQGSSHHITV 704
                                  EL+ IR ++E  E R+  +   LA    D+ +     +
Sbjct: 1052 ----------------------ELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNAL 1089

Query: 705  KINELKSVQNDSQAIAEVLNQLKDMLANFR----GSEKYCYLQNEVFGLFQKLENINGVT 760
            +I E +  Q D Q +   L+ +     +F      S     L++E+  L +K++++ G++
Sbjct: 1090 RIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLS 1149

Query: 761  DGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNL 820
              YLN L TV  ++++I   E ++K YE +L++EE V  DL  +EA+   L+   +D+  
Sbjct: 1150 TVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKD 1209

Query: 821  KKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWD 880
            K S+ + +  E+ KA+ +  Q S+  P  +LDL ++ EK +QL +RW R+  Q++ R  +
Sbjct: 1210 KNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSE 1269

Query: 881  LEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGK 940
            LE   + L +YR  +    KW+ +   +Q+ ++  +  DS  +   L++Q  L +EI   
Sbjct: 1270 LESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERN 1329

Query: 941  RDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVH 1000
            + K ++ QK ++  +  +KDYELQL +Y + +E+    P KR  + S S  I QE  D+ 
Sbjct: 1330 QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLR 1389

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKL-----KNTKIEVLEEEL----RLARD----A 1047
             RY  L+T +  + +++S+ L+ LE+ +      K   +E ++E L     LAR+    A
Sbjct: 1390 TRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKA 1449

Query: 1048 NSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKEL 1107
             S    ++  +++ + + Q    +   K   + E  + +++    AK        + K++
Sbjct: 1450 TSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI--FLAKHGHKLSEKEKKQI 1507

Query: 1108 NEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQK--ARQCEKENLGWQKLESEKAIK 1165
            +E++  L           K+  D  D   N   QLQ   A Q E++ L  Q+    + ++
Sbjct: 1508 SEQLNAL----------NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557

Query: 1166 EK-EYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEI 1224
            +   +  +  R L   +G   R  + +L+ ++ +   ++ +L++  +       T +K+I
Sbjct: 1558 DLCSWVGQAERALAGHQG---RTTQQDLSALQKN-QSDLKDLQDDIQNRATSFATVVKDI 1613

Query: 1225 -SMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKA---- 1279
                +E+ +K    +L  L  +    K++   L +    A ++   A  +ALQQ+     
Sbjct: 1614 EGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSK 1673

Query: 1280 CGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE--- 1336
               E+ + K+ ++  L  V    S       Q L       Q     +E+   +  +   
Sbjct: 1674 AAKELAENKKKIDALLDWVTSVGSSGG----QLLTNLPGMEQLSGASLEKGALDTTDGYM 1729

Query: 1337 ---EAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRA 1393
               +A  + + + E+ K R+   +E++S +  F     I  T   Q  +    D  G+  
Sbjct: 1730 GVNQAPEKLDKQCEMMKARH---QELLSQQQNF-----ILATQSAQAFL----DQHGH-- 1775

Query: 1394 QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQ 1453
               NLT E + + ++  +L     Q + +L + E +++Q            Q L+ EL++
Sbjct: 1776 ---NLTPEEQQMLQQ--KLGELKEQYSTSLAQSEAELKQ-----------VQTLQDELQK 1819

Query: 1454 VTQMRTEESVRYKQSLDDAAKTIQDKNK---EIERLKQLIDKETNDRKCLEDENARLQRV 1510
              Q   E    ++  L+ + K +++ +K     E L  L+ ++ +  + +      L+ V
Sbjct: 1820 FLQDHKE----FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFV 1875

Query: 1511 QYDLQKA---------NSSATETIN----KLKVQEQELTRLRIDYERVSQERTVKDQDIT 1557
                QK              +E  N    KLK   +  T L     R+     +      
Sbjct: 1876 TISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYH 1935

Query: 1558 RFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQ 1617
            +FQNS   LQ   Q  E  + +L             L + +      L+EQ      L +
Sbjct: 1936 QFQNSADSLQAWMQACEANVEKL-------------LSDTVASDPGVLQEQLATTKQLQE 1982

Query: 1618 QLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQ 1677
            +L +  +  ++ +   R   ++      + +  QE    + S  ++L   L +    +++
Sbjct: 1983 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2042

Query: 1678 AHLRNEHFQKAIEDKSRSLN--ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLR 1735
            A  +++  Q+++E   +S+   E  +E +++ SL+  + +E L    +L+       D+ 
Sbjct: 2043 AIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLK------QDIA 2096

Query: 1736 RGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENL---RQEIEKFQKQAL 1792
            R +S  ++ +    +  R      +     LQG + ++ +  E L   +QE E   K+ L
Sbjct: 2097 RQKSSLEATRE---MVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2153

Query: 1793 EASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQR 1852
              +   +    +  Q ++ +  +L      +QD     +   ELN      +      + 
Sbjct: 2154 PQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEH 2213

Query: 1853 LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1912
            L  E       L+    Q+  + + +RK  +E +K+ +E+    S  +    E +++   
Sbjct: 2214 LVTELSSCGFALD--LCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLV-- 2269

Query: 1913 CRRKLEDSTRETQSQL-ETERSRYQREIDK 1941
              R  +   +ET+  +  TE S   +E++K
Sbjct: 2270 --RTFQKWLKETEGSIPPTETSMSAKELEK 2297



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 282/1552 (18%), Positives = 599/1552 (38%), Gaps = 266/1552 (17%)

Query: 608  IQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETW 667
            +Q+   + +K     V   PG  Q Q  TT ++      +   H   +E           
Sbjct: 1948 MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQE----ELAEHQVPVE----------- 1992

Query: 668  MLMELQKIRRQIEHCEG---------RMTLKNLPLADQGSSHHITVKINELKSVQNDSQA 718
               +LQK+ R I   EG         + T  ++    Q  S+ +  + + L+     SQ+
Sbjct: 1993 ---KLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS 2049

Query: 719  IAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYL----NSLCTVRALL 774
            + E L  L   +     + +   + +   G+ Q+    N      +    +SL   R ++
Sbjct: 2050 VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV 2109

Query: 775  QAILQTEDMLK--VYEARLTEE----ETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
               ++T D     V + +L E     E +CL   + E+    LKK+     + + L   +
Sbjct: 2110 TRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKES---SLKKLLPQAEMFEHLSGKL 2166

Query: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888
            +  ++   ++ +  +Q     D D+  F +++ +L    +   + +D     LE  + +L
Sbjct: 2167 QQFMENKSRMLASGNQP----DQDITHFFQQIQELNLEMEDQQENLD----TLEHLVTEL 2218

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
             +        C +  D  + QD ++                  NL  + +  +   +E +
Sbjct: 2219 SS--------CGFALDLCQHQDRVQ------------------NLRKDFTELQKTVKERE 2252

Query: 949  KIAELCANSIKDYELQLASYTSGL-ETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007
            K A  C   + ++   + ++   L ET  +IP   T +               A+ +E  
Sbjct: 2253 KDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMS--------------AKELE-- 2296

Query: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067
                   + +  +   L+D   K T +E +             NC K   L+  + +  A
Sbjct: 2297 -------KQIEHLKSLLDDWASKGTLVEEI-------------NC-KGTSLENLIMEITA 2335

Query: 1068 ECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKS 1127
              SQ K              ++G    ++L +    + ++N K  +L   + + +   ++
Sbjct: 2336 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2395

Query: 1128 VEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE----KAIKEKEYEIERLRVLLQEEGT 1183
            + +R ++   + + + +  + ++E L      S     + +K +    +     L++   
Sbjct: 2396 ILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSP 2455

Query: 1184 RKREYENELAKVRNHY-NEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRL 1242
            + ++ +  LA +   Y N + +    K + E+N       E+++ ++             
Sbjct: 2456 KIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQ------------- 2502

Query: 1243 SRENRDLKDEIVRLNDSILQATEQRRRA--EENALQQKACG------SEIMQKKQHLEIE 1294
                R L++    L  +  QA E + R    E  L     G      + +  +KQ ++  
Sbjct: 2503 ----RQLEESASHL--ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 2556

Query: 1295 LKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAK---RRW-EYENELSK 1350
            LK+   +R +    H+Q L EAA+ I     ++    ++ Q+E +   ++W E  ++L+ 
Sbjct: 2557 LKEFEARRQQ----HEQ-LNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNS 2611

Query: 1351 VRNNYDEEIISLKNQFETEINITK---------------TTIHQLTMQKEEDTSGYRA-- 1393
              +  D+ I+      E   ++++               +T  +   Q+ E+TS  R+  
Sbjct: 2612 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 2671

Query: 1394 -QIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELR 1452
             Q+D+  +E ++L +E+  L        E  +R+E      +      + R  +L+  L 
Sbjct: 2672 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA 2731

Query: 1453 QVTQMRTEESVRYKQSLDDAAKTIQDKNKE----------IERLKQLIDKETNDRKCLED 1502
               Q        ++Q  D+    + DK  +          +ERL+  + +    +K L  
Sbjct: 2732 STQQ--------FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQ 2783

Query: 1503 ENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNS 1562
             +   + +  + +    S      K  +Q Q L  L+  +E +S++   +       Q+ 
Sbjct: 2784 HSGSYEVIVAEGESLLLSVPPGEEKRTLQNQ-LVELKNHWEELSKKTADR-------QSR 2835

Query: 1563 LKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR--------RSLKEQAIKITN 1614
            LK+   + QK +  +  L     +   K  +L   L+ ++        +++  +  K  +
Sbjct: 2836 LKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRS 2895

Query: 1615 LTQQLEQAS-IVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673
            L + L  A+ I+   SE D    RD   G  +      EEL+  +  +E + ++L + QE
Sbjct: 2896 LLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQE 2955

Query: 1674 SVKQAHLRNEHFQKAIE--DKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEY 1731
            S K    + E  +  +E  D   S   S   +E+L++  E L      LE ++  LR   
Sbjct: 2956 SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ----ALEPQVDYLR--- 3008

Query: 1732 DDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQA 1791
             +  +G  E D+   +   +L  Q +++    LE++  +N      EN  + I +F  + 
Sbjct: 3009 -NFTQGLVE-DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV 3066

Query: 1792 LEASNRIQESKNQCT---QVVQERESLLVKIK--VLEQDKARLQRLEDELNRA--KSTLE 1844
             E  +++ +  ++      + ++ +SL  +I+   L  +K  + +L+ E + A  +  LE
Sbjct: 3067 REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE 3126

Query: 1845 AE-----TRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIES--EREKSEREKNSLRS 1897
             E       +K+ LE   +Q      + K +  + E  + ++E    + K   +  +   
Sbjct: 3127 EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAE 3186

Query: 1898 EIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTEC 1957
            E E LQ  +    E   ++L D     + Q++  + + Q +++ L Q   G  +    +C
Sbjct: 3187 EAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQ-QVNGLGQ---GLIQSAGKDC 3242

Query: 1958 -----EWTVDTSKLVFDGLRKKVT--AMQLYECQL---IDKTTLDKLLKGKKSVEEVASE 2007
                 E  ++     ++ L KKV     QL E  L     +  L+ LL      EE+ + 
Sbjct: 3243 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIAN 3302

Query: 2008 IQPFLRGAGSIAGASASPKEKYSLVEAK-------RKKLISPESTVMLLEAQ 2052
             +P              P  +Y +V+A+       ++ L   ++TV +L+A+
Sbjct: 3303 QKP--------------PSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3340



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 237/1268 (18%), Positives = 497/1268 (39%), Gaps = 187/1268 (14%)

Query: 850  DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
            D D+      + ++  RW  ++K++  R+  L++ +     ++D  +    WL D +   
Sbjct: 3241 DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELI 3300

Query: 910  DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANS--IKDYEL---Q 964
             + +     +   V   + EQK L   +  ++   + +Q      A S  + D E    Q
Sbjct: 3301 AN-QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3359

Query: 965  LASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSL 1024
            L S  S    LL+   K    Q     IL  A   H    E      D+     + L + 
Sbjct: 3360 LESLESRWTELLS---KAAARQKQLEDILVLAKQFH----ETAEPISDFLSVTEKKLANS 3412

Query: 1025 EDLKLKNTKIE-------VLEEEL-----------RLARDANS-ENCNKNKFLDQNLQKY 1065
            E +  +  KI+        LEE++           ++ +  +S  +  +   L + +   
Sbjct: 3413 EPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSL 3472

Query: 1066 QAECSQFK----AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL-TYEIED 1120
            QA  S+ +     K A L++    A L G+   + L+     + E+ +K++ +   + + 
Sbjct: 3473 QARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN----WLAEVEDKLSSVFVKDFKQ 3528

Query: 1121 EKRRRKSV------EDRFDQQKNDYDQLQKARQCEKENLGWQKL---ESEKAIKEKEYEI 1171
            +   R+        E+  +++KN    ++  +   K+  G + L   E    IK +  +I
Sbjct: 3529 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI 3588

Query: 1172 -----ERLRVLLQ--EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEI 1224
                 + LR L Q  +  T+ +    EL        EE++    +  T   I +   ++ 
Sbjct: 3589 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQK 3648

Query: 1225 SMQKEDDSKNL--------------------RNQLDRL----SRENRDLKDEIVRLNDSI 1260
             ++KE     L                    R  LD+L    + + + + D I +  D I
Sbjct: 3649 ELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEI 3708

Query: 1261 LQATEQRRRAEENALQQKACGSEIMQKKQHL-EIELK--------QVMQQRSEDNARHKQ 1311
              A ++ ++ E+ A  + A  +E  +K   L  I L+        QV +  S D  RHK 
Sbjct: 3709 DAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKD 3768

Query: 1312 SLEE----AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQF- 1366
            S++E     ++      +E + +  E  E   +++E  + L+  R    E    L NQF 
Sbjct: 3769 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 3828

Query: 1367 ETE------INITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTL---- 1416
            ET       I  T+  I QL      D    R Q + + +   S++E    +   L    
Sbjct: 3829 ETYEELSPWIEETRALIAQLP-SPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGP 3887

Query: 1417 ---TQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAA 1473
                   E    VEE  Q+ +   +++ +  +Q  + L +     T +   +   ++   
Sbjct: 3888 QLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQST-QITEFHDKIEPML 3946

Query: 1474 KTIQDKNKEIERLKQLIDKETND-RKCLEDENA---RLQRVQYDLQKANSSATETINKLK 1529
            +T+++ +  + R+  LI  E +  R+C+ D  +    L+++Q   +       E I + +
Sbjct: 3947 ETLENLSSRL-RMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQ 4005

Query: 1530 VQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 1589
              +++L          ++E   K   +  F   +K    +++    ++  L      D  
Sbjct: 4006 GADKDL---------AAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMA 4056

Query: 1590 KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD---VLDGHL-- 1644
                  ++ + +   L+   I  + + QQ+E A  +K+ + D L ++ +   +L   L  
Sbjct: 4057 ALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEET-DGLHEELEFIRILGADLIF 4115

Query: 1645 ----REKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESK 1700
                 EK   ++ +  +++  E L +   +  E ++ A      +Q  ++     L+ + 
Sbjct: 4116 ACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV 4175

Query: 1701 IEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISN 1760
            I++  +  +  +L      ++++L  ++    ++ + + E +   +   L L+     ++
Sbjct: 4176 IKLCTMPPVGTDLN----TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD 4231

Query: 1761 NRTLELQGLINDLQRERENLRQEIEKFQKQ---ALEASNRIQESKNQCTQVVQERESLL- 1816
                 ++  + +L+   ENL ++I   Q +   AL A  + Q +  +    +   E LL 
Sbjct: 4232 RDI--IREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD 4289

Query: 1817 ------VKIKVLEQDKARLQRLEDELNRAKSTLEAETRV-KQRLECEKQQIQNDLNQ--- 1866
                     KV+E + A+   L++++   ++T+E   +   + LE       + L     
Sbjct: 4290 AQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLE 4349

Query: 1867 -----WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE----------- 1910
                 W++   + EE  ++++S  ++++       SEIE    E+ R+E           
Sbjct: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQ----GFHSEIEDFLLELTRMESQLSASKPTGG 4405

Query: 1911 --ERCRRKLEDSTRETQSQLETERSRYQREIDK-----LRQRPYGSHRETQ-----TECE 1958
              E  R +L D+  E  SQL+ +   Y + +DK     L +   GS  +T+      E +
Sbjct: 4406 LPETAREQL-DTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK 4464

Query: 1959 WTVDTSKL 1966
            W V +SK+
Sbjct: 4465 WHVVSSKM 4472



 Score = 57.0 bits (136), Expect = 3e-07
 Identities = 201/1086 (18%), Positives = 435/1086 (40%), Gaps = 203/1086 (18%)

Query: 860  VTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGD 919
            V+   ++++ +   I  R+ +++  I++ + Y     A   W+ + KR+  +L  ++   
Sbjct: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ 3746

Query: 920  SNTVMRFLNEQKNLHSEISGKRDKSEEV-QKIAELCANSIKDYELQLASYTSGLETLLNI 978
              T  + L  QK    +I   +D  +E+    +E+     ++ +  L   T   E+L+  
Sbjct: 3747 DQTTAQ-LQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKT---ESLIQQ 3802

Query: 979  PIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLE 1038
                +++ S     L+ A  +  ++ E       +      ++  L    + + ++   +
Sbjct: 3803 YEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQ 3862

Query: 1039 EELRLARDANSE------------------NCNKNKFLDQNLQKYQAECSQFKAKLASLE 1080
            EE+R  R++ +E                  N  + + +++  QK +   +Q K      E
Sbjct: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIK------E 3916

Query: 1081 ELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK----------SVED 1130
            E++++A    ++  Q+      QI E ++KI  +   +E+   R +           + +
Sbjct: 3917 EVRQRALALDEAVSQST-----QITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRE 3971

Query: 1131 RFDQQKNDYDQLQK------ARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
                 K+   +L+K      A +   E L  +   ++K +  KE + +  +++   E  +
Sbjct: 3972 CISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIK 4031

Query: 1185 KREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSR 1244
             R  E E+  +      ++  L  K+  ++    TTIK        D++++ + L+    
Sbjct: 4032 ARAEEREIKFL------DVLELAEKFWYDMAALLTTIK--------DTQDIVHDLESPGI 4077

Query: 1245 ENRDLKDEIVRLNDSILQATEQRRRAEE-----NALQQKACGSEIMQKKQHLEIELKQVM 1299
            +   +K + V   ++I + T+      E      A    ACG          E E  +V 
Sbjct: 4078 DPSIIKQQ-VEAAETIKEETDGLHEELEFIRILGADLIFACG----------ETEKPEV- 4125

Query: 1300 QQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEI 1359
                      ++S++E     ++ NK  +    + ++  +   +Y++ L  + +  D  +
Sbjct: 4126 ----------RKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV 4175

Query: 1360 ISLKNQ--FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLT 1417
            I L       T++N  K    QL   KE     Y+ QI+    E  +   E+  LK    
Sbjct: 4176 IKLCTMPPVGTDLNTVKD---QLNEMKEFKVEVYQQQIE---MEKLNHQGELM-LKKATD 4228

Query: 1418 QTTENLRRVEEDIQQQKAT----GSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAA 1473
            +T  ++  + E + + K      G +++ R+ +LE  L  + Q        ++ +L++  
Sbjct: 4229 ETDRDI--IREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ--------FQHALEELM 4278

Query: 1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ 1533
              +    + ++  + +    + D K +E E A+   ++ D+  A+ +  ET+NK   +  
Sbjct: 4279 SWLTHTEELLDAQRPI----SGDPKVIEVELAKHHVLKNDVL-AHQATVETVNKAGNELL 4333

Query: 1534 ELTRLRIDYERVSQERTVKDQDITRFQNSLKEL----QLQKQKVEEELNRLKRTASEDSC 1589
            E +                  D +  ++ L+ +    +   QK EE   +L+ T      
Sbjct: 4334 ESSA---------------GDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTL----- 4373

Query: 1590 KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV---LDGHLRE 1646
                  ++ +G    +++  +++T +  QL  AS       +  R+Q D    L   L+ 
Sbjct: 4374 ------QQAQGFHSEIEDFLLELTRMESQLS-ASKPTGGLPETAREQLDTHMELYSQLKA 4426

Query: 1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL 1706
            K+ T  +L      ++  R  LL   +S   +  + E     +E K   ++ SK+E ER 
Sbjct: 4427 KEETYNQL------LDKGRLMLLSRDDSGSGS--KTEQSVALLEQKWHVVS-SKME-ERK 4476

Query: 1707 QSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766
              L E L      L  E +N   E+ +              T+ E    L I++  +L L
Sbjct: 4477 SKLEEALN-----LATEFQNSLQEFINW------------LTLAE--QSLNIASPPSLIL 4517

Query: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKI------- 1819
              +++ ++ E +    E+   + Q +E    + ++ NQ   + Q+++ +L+K        
Sbjct: 4518 NTVLSQIE-EHKVFANEVNAHRDQIIE----LDQTGNQLKFLSQKQDVVLIKNLLVSVQS 4572

Query: 1820 ---KVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ------QIQNDLNQWKTQ 1870
               KV+++   R + L+D   RAK   EA  ++   LE  +       +I ND ++ K Q
Sbjct: 4573 RWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQ 4632

Query: 1871 YSRKEE 1876
             S+ +E
Sbjct: 4633 LSKHKE 4638



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 201/1157 (17%), Positives = 455/1157 (39%), Gaps = 181/1157 (15%)

Query: 738  KYCYLQNEVFGLFQKLENINGVTDGYLNSLC-----TVRALLQAILQT-EDMLKVYEARL 791
            K+  L+N+V      +E +N   +  L S       ++R+ L+A+ Q  E +L+  E R 
Sbjct: 4307 KHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEERE 4366

Query: 792  TEEETVCLDLD----KVEAYRCGLKKIKNDLNLKK---SLLATMKTELQKAQQIHSQTSQ 844
             + ++          ++E +   L ++++ L+  K    L  T + +L    +++SQ   
Sbjct: 4367 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKA 4426

Query: 845  QYPLYD--LDLGKF----------GEKVTQ----LTDRWQRIDKQIDFRLWDLEKQIKQL 888
            +   Y+  LD G+           G K  Q    L  +W  +  +++ R   LE+ +   
Sbjct: 4427 KEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLA 4486

Query: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948
              ++++ Q F  WL  A++   ++ S      NTV+  + E K   +E++  RD+  E+ 
Sbjct: 4487 TEFQNSLQEFINWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELD 4545

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
            +            +L+  S    +  + N+ +    +QS    ++Q + +      +   
Sbjct: 4546 QTGN---------QLKFLSQKQDVVLIKNLLVS---VQSRWEKVVQRSIERGRSLDDARK 4593

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN--SENCNKNKFLDQNLQKYQ 1066
            R+  ++    +++  LED +        L+ EL ++ D +      +K+K   + L   Q
Sbjct: 4594 RAKQFHEAWKKLIDWLEDAE------SHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQ 4647

Query: 1067 AECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK 1126
                 +   + +   LK +  L   S  Q LD   G++++  + +   + E      R+ 
Sbjct: 4648 ---PVYDTTIRTGRALKEKTLLPEDS--QKLDNFLGEVRDKWDTVCGKSVE------RQH 4696

Query: 1127 SVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAIKEKEYEIERLRVLLQEEGTRK 1185
             +E+         D LQ         + W  K+E + A  +  +    L + L +     
Sbjct: 4697 KLEEALLFSGQFMDALQAL-------VDWLYKVEPQLAEDQPVHGDLDLVMNLMD---AH 4746

Query: 1186 REYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRE 1245
            + ++ EL K                   + + K + +E+     DD+  ++ QL  LS  
Sbjct: 4747 KVFQKELGKRTG---------------TVQVLKRSGRELIENSRDDTTWVKGQLQELSTR 4791

Query: 1246 NRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSED 1305
                        D++ + +  ++   E AL+Q    +E+ +   H+ +E        +E 
Sbjct: 4792 -----------WDTVCKLSVSKQSRLEQALKQ----AEVFRDTVHMLLE----WLSEAEQ 4832

Query: 1306 NARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQ 1365
              R + +L +  + +Q     I+  K   ++  ++R +  + ++       E I+++ + 
Sbjct: 4833 TLRFRGALPDDTEALQSL---IDTHKEFMKKVEEKRVDVNSAVA-----MGEVILAVCHP 4884

Query: 1366 FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425
                 +   T  H +T+         RA+ + +    +   +  +RL+  L++   N   
Sbjct: 4885 -----DCITTIKHWITI--------IRARFEEVLTWAK---QHQQRLETALSELVANAEL 4928

Query: 1426 VEEDIQQQKATGSEVSQRKQQ-LEVELRQVT------QMRTEESVRYKQSLDDAAKTIQD 1478
            +EE +   +   + + QR Q+ +   + +V       Q   EE  R +  +D   KT + 
Sbjct: 4929 LEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKR 4988

Query: 1479 KNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRL 1538
            KN E      +    +  RK L         +    +  N      IN+L  + Q++  L
Sbjct: 4989 KNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKN----PRINQLSARWQQVWLL 5044

Query: 1539 RIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL 1598
             ++ +R   +   + +++  F N   +  + ++K    +N  K++   D  +R   +++ 
Sbjct: 5045 ALERQRKLNDALDRLEELKEFANF--DFDVWRKKYMRWMNH-KKSRVMDFFRRIDKDQDG 5101

Query: 1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQ-----RTQEE 1653
            +  R+   +  +     T +LE  ++      D         DG++   +        ++
Sbjct: 5102 KITRQEFIDGILASKFPTTKLEMTAVADIFDRDG--------DGYIDYYEFVAALHPNKD 5153

Query: 1654 LRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL--QSLTE 1711
              R +++ + +  ++ ++    K A  +    ++  E+K R  +  ++ + R+   ++  
Sbjct: 5154 AYRPTTDADKIEDEVTRQVAQCKCA--KRFQVEQIGENKYRFGDSQQLRLVRILRSTVMV 5211

Query: 1712 NLTKEHLMLEEELRNLRLEYDDLR-RGRSEADSDKNATILELRSQLQISNNRTLELQGLI 1770
             +    + L+E L    ++ D  R RGR         T +ELR +  +    +   QG+ 
Sbjct: 5212 RVGGGWMALDEFL----VKNDPCRARGR---------TNIELREKFILPEGAS---QGMT 5255

Query: 1771 NDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQ 1830
                R R   R +          +S+   +S + CT +     +     KV+    ++L+
Sbjct: 5256 PFRSRGR---RSKPSSRAASPTRSSSSASQSNHSCTSMPSSPATPASGTKVIPSSGSKLK 5312

Query: 1831 RLEDELNRAKSTLEAET 1847
            R     + ++++L  +T
Sbjct: 5313 RPTPTFHSSRTSLAGDT 5329



 Score = 39.7 bits (91), Expect = 0.043
 Identities = 28/68 (41%), Positives = 36/68 (52%), Gaps = 4/68 (5%)

Query: 2807 SVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGS----FDATGNSSYSYSY 2862
            S SS    +    + A   +S SR GSR+GSR+GSR+ SRRGS    FD     S     
Sbjct: 5330 SNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDT 5389

Query: 2863 SFSSSSIG 2870
            S SS++ G
Sbjct: 5390 SESSAAGG 5397


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  460 bits (1183), Expect = e-128
 Identities = 262/862 (30%), Positives = 475/862 (55%), Gaps = 57/862 (6%)

Query: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 541  CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600

Query: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 657

Query: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI +++ ++++ ++D  + S 
Sbjct: 658  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSP 717

Query: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 718  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 777

Query: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 778  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 837

Query: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+K  CD++  +  L + +
Sbjct: 838  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLL 897

Query: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 898  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 957

Query: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538
            GDEC L    + S W V    G +  VPSV  ++PPPN    +   ++E  ++A++ LW+
Sbjct: 958  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWH 1017

Query: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 1018 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1077

Query: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 1078 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1117

Query: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 1118 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1167

Query: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 1168 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1227

Query: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 1228 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1287

Query: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 1288 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1347

Query: 894  NYQAFCKWLYDAKRRQDSLESM 915
            +      WL DA+RRQ+ +++M
Sbjct: 1348 SADPLGAWLQDARRRQEQIQAM 1369



 Score = 41.2 bits (95), Expect = 0.015
 Identities = 142/784 (18%), Positives = 309/784 (39%), Gaps = 110/784 (14%)

Query: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIE---------DEKRRRKSV 1128
            +L+ ++R+ EL+  + +  L      ++E   ++    + ++           +   +S+
Sbjct: 640  TLQSVQRRPELEDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI 698

Query: 1129 ED---RFDQQKNDYDQLQKA-RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184
            E+   + ++ ++D  QL  A R   ++ LG   L+  K +   +  +  L  L       
Sbjct: 699  EEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 758

Query: 1185 KREY----ENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLD 1240
             +E     E E  +V   +++  +N+  K E+        ++E+ + KE   K L+N  D
Sbjct: 759  TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELEL-KEKKIKELQNAGD 813

Query: 1241 RLSRENRDLKDEIVRLNDSILQATE---QRRRAEENALQQKACGSEIMQKKQHLEIELKQ 1297
            RL RE+   +  +     ++        Q     E  L++ A   +     +  E +L++
Sbjct: 814  RLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQK 873

Query: 1298 VMQQRSEDNARHKQS----LEEAAKTIQDKNKEIERLKAEFQEEAKR-----RWEYENEL 1348
            + +     N+  + +    LE+  +  QD+ +++   K      AKR     + +  +  
Sbjct: 874  LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPA 933

Query: 1349 SKVRNNYDEEIISLKNQFETEINITKTTIHQL------TMQKEEDTSGYRAQIDNLTREN 1402
              +R      ++++ +  + E+ + K    QL      +  K   +SG  A + ++    
Sbjct: 934  HPMRGRL--PLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLV 991

Query: 1403 RSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEES 1462
               ++E                 V+E + + +A    +     QL V+++         S
Sbjct: 992  PPPNQE-----------------VQEAVTRLEAQHQALVTLWHQLHVDMK---------S 1025

Query: 1463 VRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSAT 1522
            +   QSL    + I+  +    R      K    R+ L       Q    D Q A     
Sbjct: 1026 LLAWQSLRRDVQLIRSWSLATFRTL----KPEEQRQALHSLELHYQAFLRDSQDAGGFGP 1081

Query: 1523 ETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ---NSLKELQLQKQKVE-EELN 1578
            E  ++L + E+E       Y+++ Q      Q+ +R Q   + LK+++LQ +  E   ++
Sbjct: 1082 E--DRL-MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1138

Query: 1579 RLK--------RTASEDSCKRKKLEEELEGMRRS---LKEQAIKITNLTQQLEQASIVKK 1627
            RL+        R  ++   +++K + E+EG+ +    L  +A K+  L +    A  ++ 
Sbjct: 1139 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1198

Query: 1628 RSE---DDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684
              E     L Q R +   +L       E+L+ +S  +        Q  E V +AH     
Sbjct: 1199 ELELTLGKLEQVRSLSAIYL-------EKLKTISLVIRG-----TQGAEEVLRAHEEQLK 1246

Query: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
              +A+      L  +K  +++L++  E        L +ELR  +   + L++   E D +
Sbjct: 1247 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1306

Query: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
                +   R ++     R   +    +  QRE E L +++  +++ A      +Q+++ +
Sbjct: 1307 ----VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362

Query: 1805 CTQV 1808
              Q+
Sbjct: 1363 QEQI 1366



 Score = 38.5 bits (88), Expect = 0.097
 Identities = 46/187 (24%), Positives = 85/187 (45%), Gaps = 13/187 (6%)

Query: 1693 SRSLNESKIEIERLQSLTENL---TKEHLML-EEELRNLRLEYDDLRRGRSEADSDKNAT 1748
            ++ LN SK  +  L+SL   +   TKE + L E+E   +  ++ D    R+   + K  +
Sbjct: 735  AKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSD----RNTNMTAKKES 790

Query: 1749 ILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQV 1808
               L  +L++   +  ELQ   + L RE    R  +E FQ  AL+           C + 
Sbjct: 791  YSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ-AALQTQWSWMLQLCCCIEA 849

Query: 1809 -VQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE--TRVKQRLECEKQQIQNDLN 1865
             ++E  +       + + + +LQ+L++ L R  S   +   TR++  L+ + Q  +  LN
Sbjct: 850  HLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQ-DAQDEKEQLN 908

Query: 1866 QWKTQYS 1872
            ++K   S
Sbjct: 909  EYKGHLS 915



 Score = 37.4 bits (85), Expect = 0.22
 Identities = 70/358 (19%), Positives = 140/358 (39%), Gaps = 52/358 (14%)

Query: 867  WQRIDKQIDF-RLWDL--------EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917
            WQ + + +   R W L        E+Q + L +   +YQAF +         DS ++  F
Sbjct: 1029 WQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLR---------DSQDAGGF 1079

Query: 918  GDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETL 975
            G  + +M  R      + + ++    ++  + +   + C + +KD  LQL +  +     
Sbjct: 1080 GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR 1139

Query: 976  LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIE 1035
            L +P+ +     P+    Q  A+      E+        R  +E  K L  L   +    
Sbjct: 1140 LRLPLDK----EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAP 1194

Query: 1036 VLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ 1095
             L  EL L                  L++ ++  + +  KL ++  + R  +     A++
Sbjct: 1195 TLRSELELTLG--------------KLEQVRSLSAIYLEKLKTISLVIRGTQ----GAEE 1236

Query: 1096 NLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL-------QKARQC 1148
             L     Q+KE  + +     E+E  K   K +  + + Q+  +D L       Q+  + 
Sbjct: 1237 VLRAHEEQLKEA-QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1295

Query: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNL 1206
             ++  G + +E E+  +     +ER + +L +   R+RE E +L +   +Y E    L
Sbjct: 1296 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE-QLGRQLRYYRESADPL 1352



 Score = 32.0 bits (71), Expect = 9.0
 Identities = 47/247 (19%), Positives = 104/247 (42%), Gaps = 16/247 (6%)

Query: 1666 RQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIE-IERLQ-SLTENLTKEHLMLEEE 1723
            +QLLQ  E   Q   R +     ++D    L   +   + RL+  L +   +E      E
Sbjct: 1099 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1158

Query: 1724 LRNLRLEYDDLRRG--RSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLR 1781
             +  + E + L +G  R  A+++K   +L L      +     EL+  +  L++ R    
Sbjct: 1159 QQKAQAEVEGLGKGVARLSAEAEK---VLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1215

Query: 1782 QEIEKFQKQAL--EASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1839
              +EK +  +L    +   +E      + ++E +++   +  LE  KA L++L  +    
Sbjct: 1216 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ 1275

Query: 1840 KSTLEA-------ETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK 1892
            + T +A          V +RL+    +   ++ +W+ + ++  E  + + ++ +  +RE 
Sbjct: 1276 QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL 1335

Query: 1893 NSLRSEI 1899
              L  ++
Sbjct: 1336 EQLGRQL 1342


>gi|207452735 epiplakin 1 [Homo sapiens]
          Length = 5090

 Score =  382 bits (981), Expect = e-105
 Identities = 283/872 (32%), Positives = 439/872 (50%), Gaps = 91/872 (10%)

Query: 1964 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGS 2017
            ++ V DGL       +L E Q+     +D L   + SVE+      V  E+   L  A  
Sbjct: 1263 AQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAER 1322

Query: 2018 IAGASASP--KEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 2075
             A     P  +   SL +A  K L+     + LL+ Q ATGG++DP     L   +A   
Sbjct: 1323 AAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRL 1382

Query: 2076 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 2135
             L+D    Q + A +K    F DP +   V+  +  ++ + D ETG+ LL     +   V
Sbjct: 1383 GLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEV 1442

Query: 2136 DPVNSVFL-----PKDVALARGLIDR--DLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE 2188
            D   +V L     P      +G      DL  S     D ++  V      + + ++   
Sbjct: 1443 DDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALR--- 1499

Query: 2189 RCRIEPHTGLLLLSVQKRSM--SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEV 2246
              ++      L+ + +++ +  +F+G+R+ V+  +L  + ++   T++EL  G  +  EV
Sbjct: 1500 --QVVSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEV 1557

Query: 2247 GER--IKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDP 2304
             E   +K  L+G + IAG+  + T++++ I EA++  ++RPGTAL LLEAQAATGFI+DP
Sbjct: 1558 AEMDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDP 1617

Query: 2305 VSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHG 2364
              N +L VEEA+K G+ G E   KLLSAERAVTGY DP TG  ISLFQAM K+LI + HG
Sbjct: 1618 AENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHG 1677

Query: 2365 IRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENL 2424
            IRLLEAQIATGGIIDP  SHR+PVD+AY+ GYF+EE++ IL+DPSDDTKGFFDPNT ENL
Sbjct: 1678 IRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENL 1737

Query: 2425 TYLQLKERCIKDEETGLCLLPLKEKKKQ---VQTSQKNTLRKRRVVIVDPETNKEMSVQE 2481
            TYLQL ERC++D ETGL LL + +K +    +  + ++ L+ R           +M V  
Sbjct: 1738 TYLQLLERCVEDPETGLYLLQIIKKGENYVYINEATRHVLQSR---------TAKMRVGR 1788

Query: 2482 AYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDR 2541
             +   ++ +            W+ +       S+     DRK                 R
Sbjct: 1789 -FADQVVSF------------WDLL-------SSPYFTEDRK-----------------R 1811

Query: 2542 KFFDQYRSGSLSLTQFADMISL--------KNGVGTSSSMGSGVSDDVFSSSRHESVSKI 2593
            +   +Y + S  L +  ++I+           G+  ++  G   + D+F+S     V   
Sbjct: 1812 ELIQEYGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNS----RVIDQ 1867

Query: 2594 STISSVRNLTIRSSSFSDT------LEESSPIAAIFDTENLEKISITEGIERGIVDSITG 2647
             T+ ++R       + S        LE S  IA +      E +S+ E   + ++ +   
Sbjct: 1868 KTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927

Query: 2648 QRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKM 2707
              LLEAQA TG ++ P T QKLS+ +AV  G++++++  RL  A++A  G+        +
Sbjct: 1928 TWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTI 1987

Query: 2708 SAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDT 2767
               +A++++ +      R LE Q  TGG++DP+ H R+  E A R+G +       + D 
Sbjct: 1988 PLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQ 2047

Query: 2768 SSYAKILTCPKTKLKISYKDAINRSMVEDITG 2799
                K    P T+ K+SY++   R   ++ TG
Sbjct: 2048 KHMRKRFVDPNTQEKVSYRELQERCRPQEDTG 2079



 Score =  372 bits (955), Expect = e-102
 Identities = 287/963 (29%), Positives = 449/963 (46%), Gaps = 149/963 (15%)

Query: 1934 RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDK 1993
            RY++    L Q       ETQ + +       ++   LR +VT  QL E  +ID+  LD+
Sbjct: 853  RYRQREVTLGQVAKLLEAETQRQAD-------IMLPALRSRVTVHQLLEAGIIDQQLLDQ 905

Query: 1994 LLKGKKSVEEVA--SEIQPFLRGAGSIAGASASPK-EKYSLVEAKRKKLISPESTVMLLE 2050
            +L G  S E +     ++ +L G G++ G    P  ++ SL +A R+KL+ P   + LLE
Sbjct: 906  VLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLE 965

Query: 2051 AQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEA 2110
            AQAATG I+DPH  E L+VD A+ R ++  +   ++  AE AI GF DPFSGK VSV +A
Sbjct: 966  AQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQA 1025

Query: 2111 IKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQK 2170
            +KK LI  E   RLLEAQ+A+GG++DP +   LP  VA+ RG +D+++  +L+    S +
Sbjct: 1026 MKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALS---SSSE 1082

Query: 2171 NFVDPVTKKKVSYVQLKERCRIEPHTGLLLL-------------SVQKRSMSFQGIRQPV 2217
             F  P  + + SY QL E C  +  +GL LL              VQ+   +  G +   
Sbjct: 1083 TFPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPGAKDGT 1142

Query: 2218 TVTELVDSGIL----RPSTVNELESGQISYDEVGERIKDFLQGSSCI------------- 2260
            ++ +L+ S       R   + +++ G+ +  ++   ++ ++Q +  +             
Sbjct: 1143 SLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGE 1202

Query: 2261 --------AGIYNETTKQKL--------------------------------------GI 2274
                    AGI  + T + L                                       I
Sbjct: 1203 VPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASI 1262

Query: 2275 YEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAER 2334
             +A++ GL+  G    LLEAQ A+GF+VDP++N RL VE+A K GLVG E  E+L  AER
Sbjct: 1263 AQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAER 1322

Query: 2335 AVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKR 2394
            A  GY DP +   +SL+QAM K L+ +  G+ LL+ Q+ATGG++DP     LP   A + 
Sbjct: 1323 AAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRL 1382

Query: 2395 GYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL-KEKKKQV 2453
            G  + + S++L+    D K FFDP+  + +TY QL+ERC+ D ETGL LLPL  +   +V
Sbjct: 1383 GLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEV 1442

Query: 2454 QTSQKNTLRKRRV-VIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSD 2512
                   LR  +V V         +S+ +      +  +  +EL    C           
Sbjct: 1443 DDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVAL-CRSGRAAALRQV 1501

Query: 2513 GSTRVVLVD-----------RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMI 2561
             S    LV+           R    Q   +D     L+ RK  D+   G+ ++ + A+M 
Sbjct: 1502 VSAVTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMD 1561

Query: 2562 SLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621
            S+K                                               +LE  + IA 
Sbjct: 1562 SVKR----------------------------------------------SLEGGNFIAG 1575

Query: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681
            +      E++SI E + R I+   T   LLEAQA TG II P   +KL++++A   G+  
Sbjct: 1576 VLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFG 1635

Query: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741
            ++   +L  A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP  
Sbjct: 1636 KETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVH 1695

Query: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801
              R+  + A R G+ D    + L D S   K    P T   ++Y   + R + +  TGL 
Sbjct: 1696 SHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLY 1755

Query: 2802 LLE 2804
            LL+
Sbjct: 1756 LLQ 1758



 Score =  345 bits (885), Expect = 4e-94
 Identities = 253/814 (31%), Positives = 406/814 (49%), Gaps = 68/814 (8%)

Query: 2015 AGSIAGASASPK-EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAI 2073
            A SIAG       +  S+  A  + L+       LLEAQAATGG++D  R + L V  A+
Sbjct: 40   ARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKAL 99

Query: 2074 ARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGG 2133
             + L+  + ++++ AAE+A TG+ DP+ G+ +++ +AI K ++DR  G   LE Q+A+GG
Sbjct: 100  QQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGG 159

Query: 2134 VVDPVNSVFLPKDVALARGLIDRDLYRSLND--PRDSQKNFVDPVTKKKVSYVQLKERCR 2191
            +VDP   V +  + A  +GL+DR+ +  L++  P      F++P T ++++Y QL ERC 
Sbjct: 160  LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERCV 219

Query: 2192 IEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER-- 2249
              P +GL LL ++   ++F+ +   V+  EL++ GIL    V  L  G+++  +V  R  
Sbjct: 220  RAPGSGLALLPLK---ITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAE 276

Query: 2250 IKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLR 2309
            ++ +L+G+  +AG+       K   ++A    L+  GTAL LLEAQAAT  +VDP++  R
Sbjct: 277  VRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQR 336

Query: 2310 LPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLE 2369
            L V+EA + GLV  E  E+LL AE+AVTG++DP +G+ I LFQAM K L+++   +RLL+
Sbjct: 337  LWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLD 396

Query: 2370 AQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQL 2429
            AQ+ATGG++ P    RLP++ A + G  +E+    LS       G F   T   L Y QL
Sbjct: 397  AQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQ-----AGSFSDGTHGGLRYEQL 451

Query: 2430 KERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLID 2489
               C+ D ETGL  LPL    +  +      ++               S ++A       
Sbjct: 452  LALCVTDPETGLAFLPLSGGPRGGEPQGPPFIK--------------YSTRQALSTATAT 497

Query: 2490 YETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRS 2549
                K        WE +         R +L                          QY+ 
Sbjct: 498  VSVGKFRGRPVSLWELLFSEAISSEQRAMLA------------------------QQYQE 533

Query: 2550 GSLSLTQFADMIS--LKNGVGTSSSMGSGVSD----------DVFSSSRHESVSK-ISTI 2596
            G+LS+ + A  +S  L+    T+    SG+ D          ++     +E +    +T 
Sbjct: 534  GTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATA 593

Query: 2597 SSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQAC 2656
              V +L    +S    L+ +  IA +    + E++SI E   +G++   T   LLEAQA 
Sbjct: 594  KDVGSL----ASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAA 649

Query: 2657 TGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEK 2716
            TG II P   +  S+++A+   VI  D+  +L  A++A  G+      +++S  +A+++ 
Sbjct: 650  TGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKG 709

Query: 2717 WLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTC 2776
             +  E G R LE Q  TGG++DP    R+  + A R+G+ D      L D S   K    
Sbjct: 710  LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFD 769

Query: 2777 PKTKLKISYKDAINRSMVEDITGLRLLEAASVSS 2810
            P T   ++Y   + R + +  TGL LL  +S  S
Sbjct: 770  PNTHENLTYLQLLERCVRDPETGLYLLPLSSTQS 803



 Score =  339 bits (870), Expect = 2e-92
 Identities = 286/963 (29%), Positives = 445/963 (46%), Gaps = 159/963 (16%)

Query: 1965 KLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGAS 2022
            K+ F  +   V+A +L E  ++D+  +  L +G+ +  +V++  E++ +L G GS+AG  
Sbjct: 232  KITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVV 291

Query: 2023 ASPK-EKYSLVEAKRKKLISPESTVMLLEAQAAT-------------------GGIIDPH 2062
              P+  K S  +A  + L+   + + LLEAQAAT                    G++ P 
Sbjct: 292  LLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPE 351

Query: 2063 RNEKLTVDS-------------------AIARDLIDFDDRQQIYAAEKAITGFDDPFSGK 2103
             +E+L V                     A+ + L+D     ++  A+ A  G   P    
Sbjct: 352  LHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRL 411

Query: 2104 TVSVSEAIKKNLIDRETGMRLLEAQIASGG--------------VVDPVNSV-FLPKDVA 2148
             + +  A++   +D +T  +L +A   S G              V DP   + FLP    
Sbjct: 412  RLPLEAALRCGCLDEDTQRQLSQAGSFSDGTHGGLRYEQLLALCVTDPETGLAFLPLSGG 471

Query: 2149 LARG---------LIDRDLYRSLNDPRDSQKNFVDPVTKKKVSY---VQLKERCRIEPHT 2196
               G            R    +        K    PV+  ++ +   +  ++R  +    
Sbjct: 472  PRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAISSEQRAMLAQQY 531

Query: 2197 GLLLLSVQKRS---------------MSFQGIRQPVTVTELVDSGILRPSTVNELESGQI 2241
                LSV+K +               ++F G+R  VT  EL+ + I+       LE GQ 
Sbjct: 532  QEGTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQA 591

Query: 2242 SYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATG 2299
            +  +VG     + +LQG+ CIAG+    ++++L IYEA   GL+RPGTAL LLEAQAATG
Sbjct: 592  TAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATG 651

Query: 2300 FIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELI 2359
            FI+DP +N    VEEA +  ++G +   KLLSAERAVTGY DP TG  ISLFQAM K LI
Sbjct: 652  FIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLI 711

Query: 2360 EKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPN 2419
             + HGIRLLEAQIATGG+IDP  SHR+PVD+AY+RGYF++ L+ IL DPSDDTKGFFDPN
Sbjct: 712  VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPN 771

Query: 2420 TEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSV 2479
            T ENLTYLQL ERC++D ETGL LLPL   +  +  S      +  ++ V          
Sbjct: 772  THENLTYLQLLERCVRDPETGLYLLPLSSTQSPLVDSATQQAFQNLLLSV---KYGRFQG 828

Query: 2480 QEAYKKGLIDYETFKELCEQEC----EWEEITITGSDGSTRVVLVDRKTGSQYDI----- 2530
            Q      LI+ E F E   ++        E+T+          L++ +T  Q DI     
Sbjct: 829  QRVSAWELINSEYFSEGRRRQLLRRYRQREVTL-----GQVAKLLEAETQRQADIMLPAL 883

Query: 2531 ------QDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK------NGVGTSSSMGSGVS 2578
                     ++ G++D++  DQ  +G++S      M  ++        VG    + SG  
Sbjct: 884  RSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQR 943

Query: 2579 DDVFSSSRHE------------------------SVSKISTISSVRNLTIRSSSFSDTLE 2614
              ++ + R +                        S   +S   +VR   +    +     
Sbjct: 944  LSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKR 1003

Query: 2615 ESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDA 2674
                IA   D  + +++S+ + +++G++      RLLEAQ  TGGII PT+   L +  A
Sbjct: 1004 AEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVA 1063

Query: 2675 VSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTG 2734
            + +G +DQ+M T L  + +    F    G+ + S A+ ++E      +G   L       
Sbjct: 1064 IQRGYVDQEMETALSSSSET---FPTPDGQGRTSYAQLLEECPRDETSGLHLLPL----- 1115

Query: 2735 GLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMV 2794
                PE    + TEE +++     +A    +D +S   +L+         + +   R ++
Sbjct: 1116 ----PESAPALPTEEQVQRSL---QAVPGAKDGTSLWDLLS------SCHFTEEQRRGLL 1162

Query: 2795 EDI 2797
            ED+
Sbjct: 1163 EDV 1165



 Score =  339 bits (869), Expect = 3e-92
 Identities = 270/941 (28%), Positives = 430/941 (45%), Gaps = 137/941 (14%)

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGASAS- 2024
            F GLRK+V+A  L+  QLI + TLD+L +G  +V+EVA    ++  L G   IAG     
Sbjct: 1521 FRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVLIQG 1580

Query: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDS------------- 2071
             +E+ S+ EA R+ ++ P + ++LLEAQAATG IIDP  N KLTV+              
Sbjct: 1581 TQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYV 1640

Query: 2072 -------------------------AIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVS 2106
                                     A+ +DLI  +   ++  A+ A  G  DP     V 
Sbjct: 1641 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVP 1700

Query: 2107 VSEAIK-------------------KNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDV 2147
            V  A +                   K   D  T   L   Q+    V DP   ++L + +
Sbjct: 1701 VDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQII 1760

Query: 2148 -----------ALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCR----- 2191
                       A    L  R     +    D   +F D ++    +  + +E  +     
Sbjct: 1761 KKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTEDRKRELIQEYGAQ 1820

Query: 2192 ---IEPHTGLLLLSVQKRSMSFQGI-----RQPVTVTELVDSGILRPSTVNELESGQISY 2243
               +E    ++  ++++     QGI     R  VT  +L +S ++   T++ L  G+   
Sbjct: 1821 SGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQKTLHTLRVGRTGG 1880

Query: 2244 DEVG--ERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFI 2301
              +   E +K +L+GS CIAG+   +T++ + ++EA +  L+    A  LLEAQAATGF+
Sbjct: 1881 QALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFL 1940

Query: 2302 VDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEK 2361
            +DP +  +L V+EA   GLV  E +E+LL AERA TGY DP TG+ I LFQAM K+LIEK
Sbjct: 1941 LDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEK 2000

Query: 2362 GHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTE 2421
               +RLLE Q+ATGG+IDP+  HRLP++ AY+RG  ++++  ++SD     K F DPNT+
Sbjct: 2001 AEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQ 2060

Query: 2422 ENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQE 2481
            E ++Y +L+ERC   E+TG  L P+ +  +  +              +D ET + +    
Sbjct: 2061 EKVSYRELQERCRPQEDTGWVLFPVNKAARDSEH-------------IDDETRRAL---- 2103

Query: 2482 AYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDR 2541
                              E E  EIT+    G    +       S+Y  ++   K  + R
Sbjct: 2104 ------------------EAEQVEITVGRFRGQKPTLWA--LLNSEYVTEE--KKLQLVR 2141

Query: 2542 KFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSS-------RHESVSKIS 2594
             +    R    ++ Q    +  K           G+   + +S          E +  + 
Sbjct: 2142 MYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLE 2201

Query: 2595 TISSVRNLTIRSSSFSDTLEESSPIAAIF-----DTENLEKISITEGIERGIVDSITGQR 2649
            T  S     +        LE +S IA +           EK+SI + + +G++   T   
Sbjct: 2202 TGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALV 2261

Query: 2650 LLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSA 2709
            LLEAQA TG +I P    +LS+++ V  GV+  ++  +L  A++A  G+      +++S 
Sbjct: 2262 LLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISL 2321

Query: 2710 AEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSS 2769
             +A+++  +  E G R LE Q  TGG++DP    R+  + A R+G+ D    + L D S 
Sbjct: 2322 FQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSD 2381

Query: 2770 YAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSS 2810
              K    P T   ++Y   + R + +  TGL +L+ A   S
Sbjct: 2382 DTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRGS 2422



 Score =  330 bits (847), Expect = 9e-90
 Identities = 215/519 (41%), Positives = 294/519 (56%), Gaps = 34/519 (6%)

Query: 1977 AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASPK--EK 2028
            A  L E Q      LD   + K SV+E      V  E++  L  A   A     P   + 
Sbjct: 1927 ATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDT 1986

Query: 2029 YSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYA 2088
              L +A +K+LI     + LLE Q ATGG+IDP  + +L +++A  R  +  D    I  
Sbjct: 1987 IPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISD 2046

Query: 2089 AEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIA---SGGVVDPVNSVFLPK 2145
             +     F DP + + VS  E  ++     +TG  L     A   S  + D        +
Sbjct: 2047 QKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALEAE 2106

Query: 2146 DVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE---RCRIEPHTGLLLLS 2202
             V +  G      +R       +  N      +KK+  V++     R  ++    L+L  
Sbjct: 2107 QVEITVGR-----FRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILEL 2161

Query: 2203 VQKRSMS-----FQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE--RIKDFLQ 2255
            ++K+  S     FQGIR+ +T +EL+ S I+    + +LE+G+ +  E+ E  R+K +L+
Sbjct: 2162 IEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLE 2221

Query: 2256 GSSCIAGIYNETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRL 2310
            G+SCIAG+      Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL
Sbjct: 2222 GTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRL 2281

Query: 2311 PVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEA 2370
             VEE    G+VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEA
Sbjct: 2282 SVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA 2341

Query: 2371 QIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLK 2430
            QIATGG+IDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL 
Sbjct: 2342 QIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLL 2401

Query: 2431 ERCIKDEETGLCLLPLKEKKK---QVQTSQKNTLRKRRV 2466
             RC+ D +TGL +L L  +     Q+    +  LR  RV
Sbjct: 2402 RRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDARV 2440



 Score =  308 bits (788), Expect = 7e-83
 Identities = 271/950 (28%), Positives = 431/950 (45%), Gaps = 151/950 (15%)

Query: 1952 ETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQ 2009
            E     E    T+++ F GLR  VT  +L + ++ID+   ++L  G+ + ++V S    Q
Sbjct: 544  ELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQ 603

Query: 2010 PFLRGAGSIAGASA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLT 2068
             +L+G G IAG      +E+ S+ EA+ K L+ P + ++LLEAQAATG IIDP  N+  +
Sbjct: 604  RYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHS 663

Query: 2069 VDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQ 2128
            V+ A+   +I  D   ++ +AE+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQ
Sbjct: 664  VEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQ 723

Query: 2129 IASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKE 2188
            IA+GGV+DPV+S  +P DVA  RG  D+ L   L DP D  K F DP T + ++Y+QL E
Sbjct: 724  IATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLE 783

Query: 2189 RCRIEPHTGLLLLSVQK---------RSMSFQGI----------RQPVTVTELVDS---- 2225
            RC  +P TGL LL +              +FQ +           Q V+  EL++S    
Sbjct: 784  RCVRDPETGLYLLPLSSTQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFS 843

Query: 2226 -----GILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKL---GIYEA 2277
                  +LR     E+  GQ++     E  +   Q    +  + +  T  +L   GI + 
Sbjct: 844  EGRRRQLLRRYRQREVTLGQVAKLLEAETQR---QADIMLPALRSRVTVHQLLEAGIIDQ 900

Query: 2278 MKIGLVRPGT----ALELLE-------AQAATGFIVDPVSNLRLPVEEAYKRGLVG---- 2322
              +  V  GT    AL L++          A G +    S  RL + +A ++ L+G    
Sbjct: 901  QLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVA 960

Query: 2323 ----------------------------------IEFKEKLLSAERAVTGYNDPETGNII 2348
                                               E   +L  AE A+ G+ DP +G  +
Sbjct: 961  LALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQV 1020

Query: 2349 SLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDP 2408
            S+FQAM K LI      RLLEAQ+ATGGIIDP   H LP+ +A +RGY ++E+   LS  
Sbjct: 1021 SVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSSS 1080

Query: 2409 SDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVI 2468
            S+    F  P+ +   +Y QL E C +DE +GL LLPL E    + T ++     + V  
Sbjct: 1081 SET---FPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPG 1137

Query: 2469 VDPETN-----KEMSVQEAYKKGLID-----YETFKELCEQECEWEEITITGSDGSTRVV 2518
                T+           E  ++GL++       T  +L      W + T   +      V
Sbjct: 1138 AKDGTSLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQAR---V 1194

Query: 2519 LVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVS 2578
            +V    G    +   +D G++ ++  +    G+ S  Q A+  ++K     +   G+G  
Sbjct: 1195 MVPGPRGEVPAVW-LLDAGIITQETLEALAQGTQSPAQVAEQPAVK-----ACLWGTGCV 1248

Query: 2579 DDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIE 2638
              V       S +K S   +VR+  + +      LE       + D  N +++S+ + ++
Sbjct: 1249 AGVL---LQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVK 1305

Query: 2639 RGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGF 2698
             G+V     ++L +A+    G   P +   LSL  A+ +G++                  
Sbjct: 1306 VGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLV------------------ 1347

Query: 2699 EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG-RISTEEAIRKGFID 2757
                                P   G   L+ Q  TGG+VDP VHG  +    A R G +D
Sbjct: 1348 --------------------PQNEGLPLLQVQLATGGVVDP-VHGVHLPQAAACRLGLLD 1386

Query: 2758 GRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAAS 2807
             + +Q L       K    P  + +++Y+    R + +  TGL LL   S
Sbjct: 1387 TQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPS 1436



 Score =  296 bits (758), Expect = 2e-79
 Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)

Query: 2208 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 2265
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 2706 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 2765

Query: 2266 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 2320
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 2766 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 2825

Query: 2321 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 2380
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 2826 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 2885

Query: 2381 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 2440
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL  RC+ D +TG
Sbjct: 2886 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 2945

Query: 2441 LCLLPLKEKKK---QVQTSQKNTLRKRRV 2466
            L +L L  +     Q+    +  LR  RV
Sbjct: 2946 LYMLQLAGRGSAVHQLSEELRCALRDARV 2974



 Score =  296 bits (758), Expect = 2e-79
 Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)

Query: 2208 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 2265
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 3240 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 3299

Query: 2266 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 2320
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 3300 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 3359

Query: 2321 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 2380
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 3360 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 3419

Query: 2381 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 2440
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL  RC+ D +TG
Sbjct: 3420 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 3479

Query: 2441 LCLLPLKEKKK---QVQTSQKNTLRKRRV 2466
            L +L L  +     Q+    +  LR  RV
Sbjct: 3480 LYMLQLAGRGSAVHQLSEELRCALRDARV 3508



 Score =  296 bits (758), Expect = 2e-79
 Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)

Query: 2208 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 2265
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 3774 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 3833

Query: 2266 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 2320
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 3834 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 3893

Query: 2321 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 2380
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 3894 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 3953

Query: 2381 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 2440
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL  RC+ D +TG
Sbjct: 3954 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 4013

Query: 2441 LCLLPLKEKKK---QVQTSQKNTLRKRRV 2466
            L +L L  +     Q+    +  LR  RV
Sbjct: 4014 LYMLQLAGRGSAVHQLSEELRCALRDARV 4042



 Score =  296 bits (758), Expect = 2e-79
 Identities = 157/269 (58%), Positives = 197/269 (73%), Gaps = 10/269 (3%)

Query: 2208 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 2265
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 4308 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4367

Query: 2266 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 2320
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 4368 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4427

Query: 2321 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 2380
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 4428 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 4487

Query: 2381 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 2440
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTY+QL  RC+ D +TG
Sbjct: 4488 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTG 4547

Query: 2441 LCLLPLKEKKK---QVQTSQKNTLRKRRV 2466
            L +L L  +     Q+    +  LR  RV
Sbjct: 4548 LYMLQLAGRGSAVHQLSEELRCALRDARV 4576



 Score =  293 bits (750), Expect = 2e-78
 Identities = 153/246 (62%), Positives = 187/246 (76%), Gaps = 7/246 (2%)

Query: 2208 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYN 2265
            +SF+G+R+ V+ +EL  SGIL P T+ +L  G  +  EV E   +K +L+G+SCIAG+  
Sbjct: 4842 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4901

Query: 2266 ETTKQ-----KLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGL 2320
                Q     K+ IY+AM  G++RPGTAL LLEAQAATGF++DPV NLRL VEEA   G+
Sbjct: 4902 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4961

Query: 2321 VGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDP 2380
            VG E +EKLLSAERAVTGY DP TG  ISLFQAM K+LI + HGIRLLEAQIATGG+IDP
Sbjct: 4962 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 5021

Query: 2381 KESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETG 2440
              SHR+PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL +R   D ETG
Sbjct: 5022 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETG 5081

Query: 2441 LCLLPL 2446
            L  L L
Sbjct: 5082 LLFLSL 5087



 Score =  229 bits (584), Expect = 3e-59
 Identities = 241/958 (25%), Positives = 411/958 (42%), Gaps = 130/958 (13%)

Query: 1910 EERCRRKLED--STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLV 1967
            EE+ R  LED    R T  QL     R+ +E   L Q                   ++++
Sbjct: 1155 EEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQ-------------------ARVM 1195

Query: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASASP 2025
              G R +V A+ L +  +I + TL+ L +G +S  +VA +  ++  L G G +AG    P
Sbjct: 1196 VPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQP 1255

Query: 2026 K-EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084
               K S+ +A R  L+       LLEAQ A+G ++DP  N++L+V+ A+   L+  +  +
Sbjct: 1256 SGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSE 1315

Query: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144
            Q+  AE+A  G+ DP+S  ++S+ +A++K L+ +  G+ LL+ Q+A+GGVVDPV+ V LP
Sbjct: 1316 QLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLP 1375

Query: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204
            +  A   GL+D    + L       K F DP  + +V+Y QL+ERC  +  TGLLLL + 
Sbjct: 1376 QAAACRLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLP 1435

Query: 2205 K---------RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE------- 2248
                       +++ + ++ PV+        +   S  + L S  +  D+  E       
Sbjct: 1436 SDTVLEVDDHTAVALRAMKVPVSTGRFKGCSV---SLWDLLLSEYVGADKRRELVALCRS 1492

Query: 2249 -RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSN 2307
             R     Q  S +  +     +Q L   +A   GL +  +A +L  AQ  +   +D +S 
Sbjct: 1493 GRAAALRQVVSAVTALVEAAERQPL---QATFRGLRKQVSARDLFRAQLISRKTLDELSQ 1549

Query: 2308 LRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRL 2367
                V+E  +   V     ++ L     + G     T   +S+ +A+ + ++  G  + L
Sbjct: 1550 GTTTVKEVAEMDSV-----KRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVL 1604

Query: 2368 LEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYL 2427
            LEAQ ATG IIDP E+ +L V+ A+K G F +E    L        G+ DP T + ++  
Sbjct: 1605 LEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLF 1664

Query: 2428 QLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGL 2487
            Q  ++ +   E G+ LL     + Q+ T            I+DP  +  + V  AY+ G 
Sbjct: 1665 QAMQKDLIVREHGIRLL-----EAQIATGG----------IIDPVHSHRVPVDVAYRCGY 1709

Query: 2488 IDYETFKELCEQECEWEEITITGS-DGSTRVVLVDR---------------KTGSQYDIQ 2531
             D E  + L +   + +      + +  T + L++R               K G  Y   
Sbjct: 1710 FDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQIIKKGENYVYI 1769

Query: 2532 DAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVS 2591
            +   + ++      Q R+  + + +FAD +          S    +S   F+  R   + 
Sbjct: 1770 NEATRHVL------QSRTAKMRVGRFADQVV---------SFWDLLSSPYFTEDRKREL- 1813

Query: 2592 KISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIE-RGIVDSITGQRL 2650
                   ++    +S      LE  +      +T+N       +GI+   I   +T   L
Sbjct: 1814 -------IQEYGAQSGGLEKLLEIITTTIEETETQN-------QGIKVAAIRGEVTAADL 1859

Query: 2651 LEAQACTGGIIHP-----TTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKK 2705
              ++      +H      T GQ LS  + V   +   D             G      ++
Sbjct: 1860 FNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSD----------CIAGVTVPSTRE 1909

Query: 2706 KMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQ 2765
             MS  EA +++ +P       LE Q  TG L+DP    ++S +EA+  G ++    +RL 
Sbjct: 1910 VMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLL 1969

Query: 2766 DTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAP 2823
                 A     P T   I    A+ + ++E    LRLLE   V++ G+  P +    P
Sbjct: 1970 KAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLLE-VQVATGGVIDPQHHHRLP 2026



 Score =  228 bits (581), Expect = 7e-59
 Identities = 174/594 (29%), Positives = 297/594 (50%), Gaps = 37/594 (6%)

Query: 1921 TRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQL 1980
            T + + +L  E       ++KL +    +  ET+T+         +    +R +VTA  L
Sbjct: 1806 TEDRKRELIQEYGAQSGGLEKLLEIITTTIEETETQ------NQGIKVAAIRGEVTAADL 1859

Query: 1981 YECQLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASA-SPKEKYSLVEAKRK 2037
            +  ++ID+ TL  L  G+   + +++   ++P+L G+  IAG +  S +E  SL EA RK
Sbjct: 1860 FNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRK 1919

Query: 2038 KLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFD 2097
            +LI       LLEAQAATG ++DP   +KL+VD A+   L++ + R+++  AE+A TG+ 
Sbjct: 1920 ELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYR 1979

Query: 2098 DPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRD 2157
            DP +G T+ + +A++K LI++   +RLLE Q+A+GGV+DP +   LP + A  RG + +D
Sbjct: 1980 DPATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKD 2039

Query: 2158 LYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGI---R 2214
            +Y  ++D +  +K FVDP T++KVSY +L+ERCR +  TG +L  V K +   + I    
Sbjct: 2040 IYALISDQKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVNKAARDSEHIDDET 2099

Query: 2215 QPVTVTELVDSGILR-----PSTVNELESGQISYDEVGERIKDF----LQGSSCIAGIYN 2265
            +     E V+  + R     P+    L S  ++ ++  + ++ +     +    +A +  
Sbjct: 2100 RRALEAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLIL 2159

Query: 2266 E-TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIE 2324
            E   KQ+         G+ R  TA ELL +   T  ++  +   R   +E  +   V   
Sbjct: 2160 ELIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRY 2219

Query: 2325 FKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESH 2384
             +     A   V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + 
Sbjct: 2220 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 2279

Query: 2385 RLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444
            RL V+     G    E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL
Sbjct: 2280 RLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 2339

Query: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 2498
                 + Q+ T            ++DP  +  + V  AY++G  D E  + L +
Sbjct: 2340 -----EAQIATGG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 2378



 Score =  198 bits (504), Expect = 6e-50
 Identities = 105/248 (42%), Positives = 167/248 (67%), Gaps = 8/248 (3%)

Query: 1964 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 2021
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 4840 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4899

Query: 2022 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 2075
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 4900 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4959

Query: 2076 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 2135
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 4960 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 5019

Query: 2136 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 2195
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++Y+QL +R  ++P 
Sbjct: 5020 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPE 5079

Query: 2196 TGLLLLSV 2203
            TGLL LS+
Sbjct: 5080 TGLLFLSL 5087



 Score =  197 bits (501), Expect = 1e-49
 Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)

Query: 1964 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 2021
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 2704 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 2763

Query: 2022 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 2075
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 2764 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 2823

Query: 2076 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 2135
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 2824 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 2883

Query: 2136 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 2195
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++YVQL  RC  +P 
Sbjct: 2884 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 2943

Query: 2196 TGLLLLSVQKR 2206
            TGL +L +  R
Sbjct: 2944 TGLYMLQLAGR 2954



 Score =  197 bits (501), Expect = 1e-49
 Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)

Query: 1964 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 2021
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 3238 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3297

Query: 2022 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 2075
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 3298 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3357

Query: 2076 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 2135
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 3358 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 3417

Query: 2136 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 2195
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++YVQL  RC  +P 
Sbjct: 3418 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 3477

Query: 2196 TGLLLLSVQKR 2206
            TGL +L +  R
Sbjct: 3478 TGLYMLQLAGR 3488



 Score =  197 bits (501), Expect = 1e-49
 Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)

Query: 1964 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 2021
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 3772 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3831

Query: 2022 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 2075
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 3832 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3891

Query: 2076 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 2135
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 3892 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 3951

Query: 2136 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 2195
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++YVQL  RC  +P 
Sbjct: 3952 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4011

Query: 2196 TGLLLLSVQKR 2206
            TGL +L +  R
Sbjct: 4012 TGLYMLQLAGR 4022



 Score =  197 bits (501), Expect = 1e-49
 Identities = 106/251 (42%), Positives = 166/251 (66%), Gaps = 8/251 (3%)

Query: 1964 SKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS--EIQPFLRGAGSIAGA 2021
            SK+ F GLR++V+A +L+   ++   TL  L +G K+++EV     ++ +L G   IAG 
Sbjct: 4306 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4365

Query: 2022 SASPK------EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIAR 2075
                K      EK S+ +A  K ++ P + ++LLEAQAATG +IDP RN +L+V+ A+A 
Sbjct: 4366 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4425

Query: 2076 DLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVV 2135
             ++  + ++++ +AE+A+TG+ DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+
Sbjct: 4426 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 4485

Query: 2136 DPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPH 2195
            DPV+S  +P DVA  RG  D ++ R L DP D  K F DP T + ++YVQL  RC  +P 
Sbjct: 4486 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4545

Query: 2196 TGLLLLSVQKR 2206
            TGL +L +  R
Sbjct: 4546 TGLYMLQLAGR 4556



 Score =  191 bits (485), Expect = 9e-48
 Identities = 120/351 (34%), Positives = 198/351 (56%), Gaps = 28/351 (7%)

Query: 1884 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE-TQSQLETER--------SR 1934
            ER + + +   +   + +   + + I++  RR LE    E T  +   ++        S 
Sbjct: 2070 ERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALEAEQVEITVGRFRGQKPTLWALLNSE 2129

Query: 1935 YQREIDKLRQ-RPYGSH--RETQTECEWTVD--------TSKLVFDGLRKKVTAMQLYEC 1983
            Y  E  KL+  R Y +H  R  QT  +  ++           L F G+R+++TA +L   
Sbjct: 2130 YVTEEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSS 2189

Query: 1984 QLIDKTTLDKLLKGKKSVEEVASE--IQPFLRGAGSIAGASASPK------EKYSLVEAK 2035
             +I +  L  L  G+ + +E+  +  ++ +L G   IAG     K      EK S+ +A 
Sbjct: 2190 AIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAM 2249

Query: 2036 RKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITG 2095
             K ++ P + ++LLEAQAATG +IDP RN +L+V+  +   ++  + ++++ +AE+A+TG
Sbjct: 2250 WKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTG 2309

Query: 2096 FDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLID 2155
            + DP++G+ +S+ +A++K+LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA  RG  D
Sbjct: 2310 YTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFD 2369

Query: 2156 RDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKR 2206
             ++ R L DP D  K F DP T + ++YVQL  RC  +P TGL +L +  R
Sbjct: 2370 EEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 2420



 Score =  108 bits (270), Expect = 8e-23
 Identities = 117/481 (24%), Positives = 195/481 (40%), Gaps = 44/481 (9%)

Query: 2334 RAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYK 2393
            R++ G     +G   S++ AM + L+  G G  LLEAQ ATGG++D      LPV  A +
Sbjct: 41   RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100

Query: 2394 RGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQV 2453
            +G    EL E L      T G+ DP   E L   Q   + + D   G   L +     Q+
Sbjct: 101  QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEV-----QL 155

Query: 2454 QTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDG 2513
             T            +VDP     ++ + A  +GL+D ET+ +L E E    ++     + 
Sbjct: 156  ATGG----------LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPN- 204

Query: 2514 STRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSM 2573
                  ++R T  Q   +     G           SG   L       S+   V  +  +
Sbjct: 205  -----TLERLTYHQLLERCVRAPG-----------SGLALLPLKITFRSMGGAVSAAELL 248

Query: 2574 GSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISI 2633
              G+ D+       E   +++ +       +R       LE +  +A +       K S 
Sbjct: 249  EVGILDEQAVQGLREG--RLAAVDVSARAEVRRY-----LEGTGSVAGVVLLPEGHKKSF 301

Query: 2634 TEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQK 2693
             +     ++   T   LLEAQA T  ++ P TGQ+L + +AV  G++  ++  +L  A++
Sbjct: 302  FQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQ 361

Query: 2694 AFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRK 2753
            A  G        ++   +A+K+  +      R L+ Q  TGGLV P    R+  E A+R 
Sbjct: 362  AVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRC 421

Query: 2754 GFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGL 2813
            G +D    ++L    S++       T   + Y+  +   + +  TGL  L  +     G 
Sbjct: 422  GCLDEDTQRQLSQAGSFS-----DGTHGGLRYEQLLALCVTDPETGLAFLPLSGGPRGGE 476

Query: 2814 P 2814
            P
Sbjct: 477  P 477



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 58/182 (31%), Positives = 99/182 (54%)

Query: 2629 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2688
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 2775 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 2834

Query: 2689 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2748
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 2835 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 2894

Query: 2749 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2808
             A R+G+ D    + L D S   K    P T   ++Y   + R + +  TGL +L+ A  
Sbjct: 2895 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 2954

Query: 2809 SS 2810
             S
Sbjct: 2955 GS 2956



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 58/182 (31%), Positives = 99/182 (54%)

Query: 2629 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2688
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 3309 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 3368

Query: 2689 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2748
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 3369 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 3428

Query: 2749 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2808
             A R+G+ D    + L D S   K    P T   ++Y   + R + +  TGL +L+ A  
Sbjct: 3429 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 3488

Query: 2809 SS 2810
             S
Sbjct: 3489 GS 3490



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 58/182 (31%), Positives = 99/182 (54%)

Query: 2629 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2688
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 3843 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 3902

Query: 2689 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2748
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 3903 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 3962

Query: 2749 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2808
             A R+G+ D    + L D S   K    P T   ++Y   + R + +  TGL +L+ A  
Sbjct: 3963 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 4022

Query: 2809 SS 2810
             S
Sbjct: 4023 GS 4024



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 58/182 (31%), Positives = 99/182 (54%)

Query: 2629 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2688
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 4377 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 4436

Query: 2689 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2748
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 4437 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 4496

Query: 2749 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASV 2808
             A R+G+ D    + L D S   K    P T   ++Y   + R + +  TGL +L+ A  
Sbjct: 4497 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGR 4556

Query: 2809 SS 2810
             S
Sbjct: 4557 GS 4558



 Score = 95.1 bits (235), Expect = 9e-19
 Identities = 56/175 (32%), Positives = 96/175 (54%)

Query: 2629 EKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRL 2688
            EK+SI + + +G++   T   LLEAQA TG +I P    +LS+++AV+ GV+  ++  +L
Sbjct: 4911 EKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKL 4970

Query: 2689 KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTE 2748
              A++A  G+      +++S  +A+++  +  E G R LE Q  TGG++DP    R+  +
Sbjct: 4971 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 5030

Query: 2749 EAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803
             A R+G+ D    + L D S   K    P T   ++Y   + R+ ++  TGL  L
Sbjct: 5031 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFL 5085



 Score = 89.4 bits (220), Expect = 5e-17
 Identities = 55/191 (28%), Positives = 100/191 (52%), Gaps = 2/191 (1%)

Query: 2615 ESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDA 2674
            ++  IA ++   + +  S+   +E+G++ +  GQ LLEAQA TGG++    GQ L +  A
Sbjct: 39   QARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKA 98

Query: 2675 VSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTG 2734
            + QG++  ++  +L  A++A  G+    G +K++  +A+ ++ +    GQ +LE Q  TG
Sbjct: 99   LQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATG 158

Query: 2735 GLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTC--PKTKLKISYKDAINRS 2792
            GLVDP     ++ E A  +G +D     +L +       L    P T  +++Y   + R 
Sbjct: 159  GLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERC 218

Query: 2793 MVEDITGLRLL 2803
            +    +GL LL
Sbjct: 219  VRAPGSGLALL 229



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 42/170 (24%), Positives = 82/170 (48%), Gaps = 7/170 (4%)

Query: 2210 FQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEV-------GERIKDFLQGSSCIAG 2262
            ++G+ +P T   L+++       ++ + + ++S +E        GE  +  L     + G
Sbjct: 4920 WKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTG 4979

Query: 2263 IYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVG 2322
              +  T Q++ +++AM+  L+     + LLEAQ ATG ++DPV + R+PV+ AY+RG   
Sbjct: 4980 YTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFD 5039

Query: 2323 IEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQI 2372
             E    L        G+ DP T   ++  Q + +  ++   G+  L   +
Sbjct: 5040 EEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089



 Score = 69.7 bits (169), Expect = 4e-11
 Identities = 51/171 (29%), Positives = 82/171 (47%), Gaps = 8/171 (4%)

Query: 1967 VFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAG 2020
            ++ G+ +  TA+ L E Q      +D +   + SVEE      V  EIQ  L  A     
Sbjct: 4919 MWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVT 4978

Query: 2021 ASASPK--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLI 2078
                P   ++ SL +A +K LI  E  + LLEAQ ATGG+IDP  + ++ VD A  R   
Sbjct: 4979 GYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 5038

Query: 2079 DFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQI 2129
            D +  + +        GF DP + + ++  + +++  +D ETG+  L   +
Sbjct: 5039 DEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 2336 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 2395
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 2765 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 2824

Query: 2396 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 2455
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 2825 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 2879

Query: 2456 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 2498
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 2880 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 2912



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 2336 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 2395
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 3299 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 3358

Query: 2396 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 2455
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 3359 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 3413

Query: 2456 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 2498
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 3414 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 3446



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 2336 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 2395
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 3833 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 3892

Query: 2396 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 2455
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 3893 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 3947

Query: 2456 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 2498
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 3948 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 3980



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 2336 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 2395
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 4367 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 4426

Query: 2396 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 2455
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 4427 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 4481

Query: 2456 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 2498
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 4482 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 4514



 Score = 65.9 bits (159), Expect = 6e-10
 Identities = 47/163 (28%), Positives = 76/163 (46%), Gaps = 15/163 (9%)

Query: 2336 VTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG 2395
            V   + P     +S++QAM K ++  G  + LLEAQ ATG +IDP  + RL V+ A   G
Sbjct: 4901 VPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAG 4960

Query: 2396 YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQT 2455
                E+ E L        G+ DP T + ++  Q  ++ +   E G+ LL     + Q+ T
Sbjct: 4961 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL-----EAQIAT 5015

Query: 2456 SQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCE 2498
                        ++DP  +  + V  AY++G  D E  + L +
Sbjct: 5016 GG----------VIDPVHSHRVPVDVAYRRGYFDEEMNRVLAD 5048



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 43/168 (25%), Positives = 80/168 (47%), Gaps = 8/168 (4%)

Query: 2055 TGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGF-----DDPFSGKTVSVSE 2109
            T GI+ P     L   +   +++ + D  ++       I G      D P   + +S+ +
Sbjct: 4858 TSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQ 4917

Query: 2110 AIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQ 2169
            A+ K ++   T + LLEAQ A+G V+DPV ++ L  + A+A G++  ++   L     + 
Sbjct: 4918 AMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAV 4977

Query: 2170 KNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPV 2217
              + DP T +++S  Q  ++  I    G+ LL  Q   ++  G+  PV
Sbjct: 4978 TGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQ---IATGGVIDPV 5022



 Score = 55.5 bits (132), Expect = 8e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2626 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 2701 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 2750

Query: 2686 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2740
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 2751 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 2810

Query: 2741 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2800
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 2811 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 2870

Query: 2801 RLLEAASVSSKGLPSPYNMSSAP 2823
            RLLE A +++ G+  P +    P
Sbjct: 2871 RLLE-AQIATGGVIDPVHSHRVP 2892



 Score = 55.5 bits (132), Expect = 8e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2626 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 3235 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 3284

Query: 2686 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2740
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 3285 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 3344

Query: 2741 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2800
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 3345 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 3404

Query: 2801 RLLEAASVSSKGLPSPYNMSSAP 2823
            RLLE A +++ G+  P +    P
Sbjct: 3405 RLLE-AQIATGGVIDPVHSHRVP 3426



 Score = 55.5 bits (132), Expect = 8e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2626 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 3769 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 3818

Query: 2686 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2740
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 3819 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 3878

Query: 2741 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2800
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 3879 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 3938

Query: 2801 RLLEAASVSSKGLPSPYNMSSAP 2823
            RLLE A +++ G+  P +    P
Sbjct: 3939 RLLE-AQIATGGVIDPVHSHRVP 3960



 Score = 55.5 bits (132), Expect = 8e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2626 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 4303 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 4352

Query: 2686 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2740
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 4353 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 4412

Query: 2741 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2800
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 4413 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 4472

Query: 2801 RLLEAASVSSKGLPSPYNMSSAP 2823
            RLLE A +++ G+  P +    P
Sbjct: 4473 RLLE-AQIATGGVIDPVHSHRVP 4494



 Score = 55.5 bits (132), Expect = 8e-07
 Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 16/203 (7%)

Query: 2626 ENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMA 2685
            E L K+S      RG+   ++   L      T GI+ P T + L+      Q V + D  
Sbjct: 4837 ERLSKVSF-----RGLRRQVSASELH-----TSGILGPETLRDLAQGTKTLQEVTEMDSV 4886

Query: 2686 TRLKPAQKAFIGF-----EGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPE 2740
             R         G      +    ++KMS  +A+ +  L        LE Q  TG ++DP 
Sbjct: 4887 KRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPV 4946

Query: 2741 VHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGL 2800
             + R+S EEA+  G + G   ++L          T P T  +IS   A+ + ++    G+
Sbjct: 4947 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI 5006

Query: 2801 RLLEAASVSSKGLPSPYNMSSAP 2823
            RLLE A +++ G+  P +    P
Sbjct: 5007 RLLE-AQIATGGVIDPVHSHRVP 5028



 Score = 37.4 bits (85), Expect = 0.22
 Identities = 35/150 (23%), Positives = 62/150 (41%), Gaps = 7/150 (4%)

Query: 2673 DAVSQGVIDQDMATRL------KPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRF 2726
            ++  Q  + + MA  L      +P  ++  G       +  S   A+++  LP   GQ  
Sbjct: 15   NSTEQASVPRAMAATLGAGTPPRPQARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQAL 74

Query: 2727 LEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYK 2786
            LE Q  TGGLVD      +   +A+++G +     ++L            P    K++  
Sbjct: 75   LEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATTGYPDPYGGEKLALF 134

Query: 2787 DAINRSMVEDITGLRLLEAASVSSKGLPSP 2816
             AI + +V+   G   LE   +++ GL  P
Sbjct: 135  QAIGKEVVDRALGQSWLE-VQLATGGLVDP 163



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 6/96 (6%)

Query: 1118 IEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVL 1177
            I D+K  RK   D   Q+K  Y +LQ+ R   +E+ GW      KA ++ E+  +  R  
Sbjct: 2044 ISDQKHMRKRFVDPNTQEKVSYRELQE-RCRPQEDTGWVLFPVNKAARDSEHIDDETRRA 2102

Query: 1178 LQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETE 1213
            L+ E     + E  + + R       + L ++Y TE
Sbjct: 2103 LEAE-----QVEITVGRFRGQKPTLWALLNSEYVTE 2133


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score =  243 bits (620), Expect = 2e-63
 Identities = 147/378 (38%), Positives = 224/378 (59%), Gaps = 19/378 (5%)

Query: 2430 KERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLID 2489
            KER ++D    +     +E  ++ QT + N   K  + I++PET K+MS  EAYK+G+ID
Sbjct: 1655 KERTLRDLHAKVSR---EELSQETQTRETNLSTK--ISILEPETGKDMSPYEAYKRGIID 1709

Query: 2490 YETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRS 2549
               + +L E EC+WEE+T +G  G   V+L DRK+G QY I+ A+    + ++ +  Y+ 
Sbjct: 1710 RGQYLQLQELECDWEEVTTSGPCGEESVLL-DRKSGKQYSIEAALRCRRISKEEYHLYKD 1768

Query: 2550 GSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSF 2609
            G L +++FA +++ +    +S S+GS +S    +S   +S S  S             SF
Sbjct: 1769 GHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAPQSTSFFSP------------SF 1816

Query: 2610 SDTL-EESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQK 2668
            S  L ++S PIA I+DT    K SI   + + ++D ITGQ+LLEAQA TGGI+   + ++
Sbjct: 1817 SLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRER 1876

Query: 2669 LSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLE 2728
             S+  A+ +G+I+     RL  AQKAF G E    KK++S  EAV++ W+P E+    L+
Sbjct: 1877 YSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQ 1936

Query: 2729 FQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDA 2788
             Q+LTGGL+DP+  GRI  ++A+  G I    AQ LQD SSY K LT P +K ++SYK+A
Sbjct: 1937 VQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEA 1996

Query: 2789 INRSMVEDITGLRLLEAA 2806
            + R   + ++GL LL AA
Sbjct: 1997 MGRCRKDPLSGLLLLPAA 2014



 Score =  242 bits (618), Expect = 3e-63
 Identities = 325/1534 (21%), Positives = 653/1534 (42%), Gaps = 264/1534 (17%)

Query: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
            L + I   + +++ +EA L +E  +  +   ++     L++ + +L  +++ +  +   L
Sbjct: 637  LERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRAL 696

Query: 833  QKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFR---LWDLEKQIKQLR 889
            + ++   +     +  +  DL +   +V  LTDR+  +  Q+D R   + D     +Q +
Sbjct: 697  KASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFK 756

Query: 890  NYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRF-LNEQKNLHSEISGKRDKSEEVQ 948
            N +DN  +   WL    R Q     ++  D  + + + L  QK L  EI  +        
Sbjct: 757  NCKDNLSS---WLEHLPRSQ-----VRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATAS 808

Query: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008
             +++    +++DYELQ  +Y   LE  L +   +    +P    LQE+  + A+   L  
Sbjct: 809  HLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAP----LQES--IQAQEKNLAK 862

Query: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAE 1068
               +      ++L+ LE  +    K E L E++R   DA                     
Sbjct: 863  AYTEVAAAQQQLLQQLEFARKMLEKKE-LSEDIRRTHDA--------------------- 900

Query: 1069 CSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSV 1128
                          K+ +E   ++ +++                 L  ++E+E++R   V
Sbjct: 901  --------------KQGSESPAQAGRES---------------EALKAQLEEERKRVARV 931

Query: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIK-----EKEYEIERLRVLLQEEGT 1183
            +   + Q++   QL+  R  E+       LE ++ ++     + E  + R++  ++EEG 
Sbjct: 932  QHELEAQRSQLLQLRTQRPLER-------LEEKEVVEFYRDPQLEGSLSRVKAQVEEEGK 984

Query: 1184 RKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243
            R+   + +L +V      ++ + R   +  +   + T  E     +  +  LR Q+ +L 
Sbjct: 985  RRAGLQADL-EVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLR 1043

Query: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLE-IELKQVMQQR 1302
             E+  +   +  L   +L A E+R    E  +++K    E+++ +++LE ++  Q ++ +
Sbjct: 1044 GEDAVISARLEGLKKELL-ALEKR----EVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQ 1098

Query: 1303 SEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD--EEII 1360
             E++A  ++  EEA   +Q + +++ER  +  + +         E+ KV  +    +E  
Sbjct: 1099 MEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKV-----IVKEVKKVEQDPGLLQESS 1153

Query: 1361 SLKNQFETEINITKTTIHQLT--------MQKEEDTSGYRAQIDNLTRENRSLSEEIKRL 1412
             L++  E E     T   +L+        ++K+      + ++  + + +    +EI RL
Sbjct: 1154 RLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRL 1213

Query: 1413 KNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDA 1472
            K  L +       VE++++  K        R Q+  VE ++VTQ    E VR+++S    
Sbjct: 1214 KAKLQEMAGKRSGVEKEVE--KLLPDLEVLRAQKPTVEYKEVTQ----EVVRHERS---- 1263

Query: 1473 AKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSA-TETINKLKVQ 1531
                 +  +EI+RLK  +++  N     +++  RLQ  + + ++  +   T+T++K  V+
Sbjct: 1264 ----PEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVR 1319

Query: 1532 -------EQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTA 1584
                   E+E  RLR +    +Q+R   +  +   Q+  K L L+++K EE++   +   
Sbjct: 1320 HEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQS--KRLLLERRKPEEKVVVQEVVV 1377

Query: 1585 SEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHL 1644
            ++   K  KL EE   +  SL E+  +   L  +++Q     +  E  L  Q D      
Sbjct: 1378 TQ---KDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQED-----R 1429

Query: 1645 REKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL----RNEHFQKAIEDKSRSLNESK 1700
             +K   + ELR+L+  ++ L ++    QE +    +    ++   +K+ E     L++ K
Sbjct: 1430 SKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEK 1489

Query: 1701 IEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISN 1760
             ++  L                E +NL+++ D L++ +S+       TI   +  +++  
Sbjct: 1490 TQVTELN--------------RECKNLQVQIDVLQKAKSQ-----EKTIY--KEVIRVQK 1528

Query: 1761 NRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIK 1820
            +R LE     ++  R  E L +E  +  +QA E      E   +  + +   E+L    +
Sbjct: 1529 DRVLE-----DERARVWEMLNRE--RTARQARE------EEARRLRERIDRAETLG---R 1572

Query: 1821 VLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRK 1880
               ++++ LQR  D+ ++    L+ E R    LE +KQQ    L         +EE+  K
Sbjct: 1573 TWSREESELQRARDQADQECGRLQQELRA---LERQKQQQTLQL---------QEES--K 1618

Query: 1881 IESEREKSEREKNSLRS-EIERLQAEIKRIEERC---------------RRKLEDSTRET 1924
            + S++ +SER+K + R  E+ RL+A I R +++                R +L   T+  
Sbjct: 1619 LLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTR 1678

Query: 1925 QSQLETERSRYQREIDKLRQRPYGSHRE-----------TQTECEWTVDT--------SK 1965
            ++ L T+ S  + E  K    PY +++             + EC+W   T        S 
Sbjct: 1679 ETNLSTKISILEPETGK-DMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESV 1737

Query: 1966 LVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASP 2025
            L+     K+ +      C+ I K        G   + E A  +    + + S++  S   
Sbjct: 1738 LLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIIS 1797

Query: 2026 KEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIA----------- 2074
            K   +    +     SP  ++ L +      GI D   + K ++ +A+A           
Sbjct: 1798 KSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQK 1857

Query: 2075 ---------------------------RDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSV 2107
                                       R LI+    Q++  A+KA TG +DP + K +SV
Sbjct: 1858 LLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSV 1917

Query: 2108 SEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRD 2167
             EA++K  + RE+ +  L+ Q  +GG++DP  +  +P   AL  G+I  +L + L D   
Sbjct: 1918 GEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESS 1977

Query: 2168 SQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLL 2201
             +K+  DP++K+++SY +   RCR +P +GLLLL
Sbjct: 1978 YEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLL 2011



 Score =  227 bits (579), Expect = 1e-58
 Identities = 316/1414 (22%), Positives = 609/1414 (43%), Gaps = 179/1414 (12%)

Query: 1095 QNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDR---FDQQKNDYDQLQKARQCEKE 1151
            Q+L +   Q++ L ++   +  +++    R K V+D    + Q KN  D L        E
Sbjct: 715  QDLPRQQRQVRALTDRYHAVGDQLD---LREKVVQDAALTYQQFKNCKDNLSSWL----E 767

Query: 1152 NLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYE 1211
            +L   ++       +  Y+++  + L QE  +R+R+         +H ++ +      YE
Sbjct: 768  HLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERD-----RATASHLSQALQAALQDYE 822

Query: 1212 TEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAE 1271
             + +  + +++            +             L++ I     ++ +A  +   A+
Sbjct: 823  LQADTYRCSLEPTLAVSAPKRPRVA-----------PLQESIQAQEKNLAKAYTEVAAAQ 871

Query: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 1331
            +  LQQ     ++++KK+             SED  R     ++ +++     +E E LK
Sbjct: 872  QQLLQQLEFARKMLEKKE------------LSED-IRRTHDAKQGSESPAQAGRESEALK 918

Query: 1332 AEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH-QLTMQKEEDTSG 1390
            A+ +EE KR    ++EL   R+    +++ L+ Q   E    K  +      Q E   S 
Sbjct: 919  AQLEEERKRVARVQHELEAQRS----QLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSR 974

Query: 1391 YRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVE 1450
             +AQ++   +    L  +++     + Q     + ++  +  ++ T  E          +
Sbjct: 975  VKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQ 1034

Query: 1451 LR-QVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET-NDRKCLED-ENARL 1507
            LR Q+ Q+R E++V   +      + +  + +E++  ++++ KE     K LE  + A+ 
Sbjct: 1035 LRIQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQA 1094

Query: 1508 QRVQYDLQKAN-SSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKEL 1566
             R+Q +   A    A E + KL+ + ++L            ER +   +       +K++
Sbjct: 1095 LRLQMEEDAARRKQAEEAVAKLQARIEDL------------ERAISSVEPKVIVKEVKKV 1142

Query: 1567 QLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--RRSLKEQAIKITNLTQQLEQASI 1624
            + Q   + +E +RL+    E+  K   L  EL  +  + S+ E+      L +++ +   
Sbjct: 1143 E-QDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQ 1201

Query: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQL-LQEQESVKQAHLRNE 1683
            V   +E ++ + +  L     ++   ++E+ +L  ++E LR Q    E + V Q  +R+E
Sbjct: 1202 VDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHE 1261

Query: 1684 HFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADS 1743
               + +            EI+RL++    L   H   +E+L  L+ E D+ RR R++ ++
Sbjct: 1262 RSPEVLR-----------EIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVET 1310

Query: 1744 DKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE--S 1801
               +  +    +  +              L++E E LRQE+ +  ++   A + + E  S
Sbjct: 1311 KTVSKEVVRHEKDPV--------------LEKEAERLRQEVREAAQKRRAAEDAVYELQS 1356

Query: 1802 KNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQ 1861
            K    +  +  E ++V+  V+ Q   +L+   +E +R   +L+ E   +++LE E QQ++
Sbjct: 1357 KRLLLERRKPEEKVVVQEVVVTQKDPKLR---EEHSRLSGSLDEEVGRRRQLELEVQQLR 1413

Query: 1862 NDLNQWKTQYSRKEEAIRKIESEREK-------SEREKNSLRSEIERLQAEIKRIEERCR 1914
              + + +   S +E+  +K+  ERE         E EK     + + +  E+ ++E+   
Sbjct: 1414 AGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKD-- 1471

Query: 1915 RKLEDSTRETQSQLETERSRY----------QREIDKLRQRPYGSHRETQTEC------E 1958
              LE ST   +  L+ E+++           Q +ID L Q+     +    E        
Sbjct: 1472 PDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVL-QKAKSQEKTIYKEVIRVQKDR 1530

Query: 1959 WTVDTSKLVFDGLRKKVTAMQLYECQ---LIDKTTLDKLLKGKKSVEEVASEIQPFLRGA 2015
               D    V++ L ++ TA Q  E +   L ++    + L    S EE  SE+Q     A
Sbjct: 1531 VLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREE--SELQRARDQA 1588

Query: 2016 GSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLT-VDSAIA 2074
                G     +E  +L   K+++ +  +    LL  +  +       R ++L+ +++AI 
Sbjct: 1589 DQECGRLQ--QELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAIL 1646

Query: 2075 RDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGV 2134
            R+      + QIY  E+ +       S       E + +    RET    L  +I+   +
Sbjct: 1647 RE------KDQIYEKERTLRDLHAKVS------REELSQETQTRETN---LSTKIS---I 1688

Query: 2135 VDPVNSVFLPKDVALARGLIDRDLYRSLND------------PRDSQKNFVDPVTKKKVS 2182
            ++P     +    A  RG+IDR  Y  L +            P   +   +D  + K+ S
Sbjct: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQYS 1748

Query: 2183 YVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPST---VNELESG 2239
             ++   RCR         +S ++  +   G   P++   L+ +G  +PS+   +  + S 
Sbjct: 1749 -IEAALRCR--------RISKEEYHLYKDG-HLPISEFALLVAGETKPSSSLSIGSIISK 1798

Query: 2240 QISYDEVGERIKDFLQGSSC--------IAGIYNETTKQKLGIYEAMKIGLVRPGTALEL 2291
                    +    F    S         IAGIY+ TT  K  I  A+   ++ P T  +L
Sbjct: 1799 SPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKL 1858

Query: 2292 LEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLF 2351
            LEAQAATG IVD +S  R  V +A +RGL+     ++LL+A++A TG  DP T   +S+ 
Sbjct: 1859 LEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVG 1918

Query: 2352 QAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDD 2411
            +A+ K  + +   +  L+ Q  TGG+IDPK + R+P+  A   G  +EEL+++L D S  
Sbjct: 1919 EAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSY 1978

Query: 2412 TKGFFDPNTEENLTYLQLKERCIKDEETGLCLLP 2445
             K   DP ++E L+Y +   RC KD  +GL LLP
Sbjct: 1979 EKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012



 Score =  168 bits (426), Expect = 6e-41
 Identities = 353/1638 (21%), Positives = 664/1638 (40%), Gaps = 260/1638 (15%)

Query: 813  KIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPL-YDLDLGKFGEKVTQLTD------ 865
            ++ ++L   K  LAT+++ L+ +     + SQQ P   DL   +  + +TQ+T       
Sbjct: 480  RLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLG 539

Query: 866  -------RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDS-LESMKF 917
                    W R        L DLE +I          Q+       A++  ++ L +   
Sbjct: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599

Query: 918  GDSNTVMRF-LNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLL 976
            G +   +   LN  KN  S++        E  K A      I+D +  +  + + L    
Sbjct: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATL---- 655

Query: 977  NIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDL--KLKNTKI 1034
               ++   I +  G + +  +++  +  ELL +     R L   LK+ E     L+N   
Sbjct: 656  ---VQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLR-LHRALKASEHACAALQNNFQ 711

Query: 1035 EVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAK 1094
            E  ++  R  R   +              +Y A   Q   +    E++ + A L  +  K
Sbjct: 712  EFCQDLPRQQRQVRALT-----------DRYHAVGDQLDLR----EKVVQDAALTYQQFK 756

Query: 1095 QNLDKCYGQIKELNEKITR-------LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQ 1147
               D     ++ L     R       + Y+++ +KR  + ++ R ++ +     L +A Q
Sbjct: 757  NCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSR-ERDRATASHLSQALQ 815

Query: 1148 CEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLR 1207
                           A+++ E + +  R  L+            +A ++     +  NL 
Sbjct: 816  A--------------ALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQAQEKNLA 861

Query: 1208 NKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQR 1267
              Y TE+   +   +++  Q E   K L         E ++L ++I R +D+  Q +E  
Sbjct: 862  KAY-TEVAAAQ---QQLLQQLEFARKML---------EKKELSEDIRRTHDA-KQGSESP 907

Query: 1268 RRAEENALQQKACGSE----IMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDK 1323
             +A   +   KA   E    + + +  LE +  Q++Q R++      +  +E  +  +D 
Sbjct: 908  AQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEE-KEVVEFYRDP 966

Query: 1324 NKE--IERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFET-EINITKTTIHQL 1380
              E  + R+KA+ +EE KRR   + +L        ++++ L+++ +T + ++    + Q+
Sbjct: 967  QLEGSLSRVKAQVEEEGKRRAGLQADLEVAA----QKVVQLESKRKTMQPHLLTKEVTQV 1022

Query: 1381 TMQKEEDTSG--YRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS 1438
                  D+     R QI  L  E+  +S  ++ LK  L      L + E D++++     
Sbjct: 1023 ERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLA----LEKREVDVKEKVVVKE 1078

Query: 1439 EVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET--ND 1496
             V   K    V+  Q  +++ EE    ++  ++A   +Q + +++ER    ++ +    +
Sbjct: 1079 VVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKE 1138

Query: 1497 RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDI 1556
             K +E +   LQ    +  +  S   E   K     +EL+ L   Y  V ++R       
Sbjct: 1139 VKKVEQDPGLLQ----ESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPK----- 1189

Query: 1557 TRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE-QAIKITNL 1615
             + Q  + E+     + E+E+ RLK    E + KR  +E+E+E +   L+  +A K T  
Sbjct: 1190 VQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVE 1249

Query: 1616 TQQLEQASIVKKRSEDDLRQQRDVLDGHLRE----KQRTQEELRRLSSEVEALRRQ---- 1667
             +++ Q  +  +RS + LR+  D L   L E      R+QE+L RL  E +  RR+    
Sbjct: 1250 YKEVTQEVVRHERSPEVLREI-DRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKV 1308

Query: 1668 -----------------LLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIER----- 1705
                             L +E E ++Q        ++A ED    L   ++ +ER     
Sbjct: 1309 ETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEE 1368

Query: 1706 --------LQSLTENLTKEHLMLEEEL-------RNLRLEYDDLRRGRSEADSDKNATIL 1750
                    +      L +EH  L   L       R L LE   LR G  E +     +  
Sbjct: 1369 KVVVQEVVVTQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEG--LLSFQ 1426

Query: 1751 ELRSQLQISNNRTLELQGLINDLQR-----ERENLRQEIEKFQKQA-LEASNR-----IQ 1799
            E RS+         +L   I +L++     + + + +E+ K +K   LE S       + 
Sbjct: 1427 EDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLD 1486

Query: 1800 ESKNQCTQVVQERESLLVKIKVLEQDKA----------RLQR---LEDELNRAKSTLEAE 1846
            + K Q T++ +E ++L V+I VL++ K+          R+Q+   LEDE  R    L  E
Sbjct: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRE 1546

Query: 1847 TRVKQRLECEKQQIQNDLNQWKT---QYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ 1903
               +Q  E E ++++  +++ +T    +SR+E  +++    R+++++E   L+ E+  L+
Sbjct: 1547 RTARQAREEEARRLRERIDRAETLGRTWSREESELQRA---RDQADQECGRLQQELRALE 1603

Query: 1904 AEIKRI------EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHR------ 1951
             + ++       E +   +  +S R+  +Q   E SR +  I + + + Y   R      
Sbjct: 1604 RQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLH 1663

Query: 1952 ----------ETQTECEWTVDTSKLVFDG-LRKKVTAMQLYECQLIDKTTLDKLLKGKKS 2000
                      ETQT  E  + T   + +    K ++  + Y+  +ID+    +L + +  
Sbjct: 1664 AKVSREELSQETQTR-ETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECD 1722

Query: 2001 VEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVM-------LLEAQA 2053
             EEV +       G  S+     S K+ YS+  A R + IS E   +       + E   
Sbjct: 1723 WEEVTTSGPC---GEESVLLDRKSGKQ-YSIEAALRCRRISKEEYHLYKDGHLPISEFAL 1778

Query: 2054 ATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKA-----------ITGFDDPFSG 2102
               G   P  +  L++ S I++  +     Q       +           I G  D  + 
Sbjct: 1779 LVAGETKP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTD 1836

Query: 2103 KTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSL 2162
               S+  A+ KN++D  TG +LLEAQ A+GG+VD ++        A+ RGLI+    + L
Sbjct: 1837 NKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRL 1896

Query: 2163 NDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTEL 2222
             + + +     DPVTKK++S  +                +VQK  M  + +   + V  L
Sbjct: 1897 LNAQKAFTGIEDPVTKKRLSVGE----------------AVQKGWMPRESVLPHLQVQHL 1940

Query: 2223 VDSGILRPSTVNE------LESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYE 2276
               G++ P           L SG IS +E+ + ++D    SS    + +  +K++L   E
Sbjct: 1941 T-GGLIDPKRTGRIPIQQALLSGMIS-EELAQLLQD---ESSYEKDLTDPISKERLSYKE 1995

Query: 2277 AMKIGLVRPGTALELLEA 2294
            AM      P + L LL A
Sbjct: 1996 AMGRCRKDPLSGLLLLPA 2013



 Score =  124 bits (312), Expect = 1e-27
 Identities = 86/341 (25%), Positives = 163/341 (47%), Gaps = 10/341 (2%)

Query: 195 MRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEE 254
           + Q++ ++    +G  +A +EQ I  H  +   I  Y  QL  +            +  +
Sbjct: 156 LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGP-----DAATIRSQ 210

Query: 255 YENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQ-KQEAFS 313
           Y +LLKA+  R   L  L   +Q  +R++  + + +   L  DWSD   + A  ++E   
Sbjct: 211 YRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPAGVRREYEH 270

Query: 314 IRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLK 373
            +  +L  +E+ +N+L+ + +++V  +HPA   I+A+ + L+ +W   L +  C +  L+
Sbjct: 271 FKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQ 330

Query: 374 ENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKR 433
               Y +F EEA S    L  L  ++  KY      P     E +++LE E +++   +R
Sbjct: 331 HVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTER 390

Query: 434 QVQNLVNKSKKIVQL-KPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSK 492
              +L  +S+ +  L + RNP     +P+ + ++CD+   +  + +G+   L DN +   
Sbjct: 391 ATGDLQRRSRDVAPLPQRRNP---PQQPLHVDSICDWDSGEVQLLQGERYKLVDNTDPHA 447

Query: 493 WYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAI 533
           W V GPGG     P+    IP P+P AV  + ++    +A+
Sbjct: 448 WVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQAL 488



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 234/1277 (18%), Positives = 459/1277 (35%), Gaps = 283/1277 (22%)

Query: 1201 EEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQ--LDRLSRENRDLKDEIVRLND 1258
            +E++ L ++ +   +  +  I E   + + D  N      L       R LK+  V L D
Sbjct: 37   QELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKD 96

Query: 1259 SILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEA-- 1316
              L   + RR     A              + +E ++KQ+ ++ +++ A ++   E+   
Sbjct: 97   LFLDVDKARRLKHPQA--------------EEIEKDIKQLHERVTQECAEYRALYEKMVL 142

Query: 1317 ----------AKTIQDKNKEI-ERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQ 1365
                      A+ ++ K K++          E +++    N L K  + Y +++ SL   
Sbjct: 143  PPDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGP 202

Query: 1366 FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLK----NTLTQTTE 1421
                I      + +    + +        +   TR+  +L+E+ +R+     + L     
Sbjct: 203  DAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPA 262

Query: 1422 NLRRVEEDIQQQKATGSEVSQRKQQLE------VELR----------------------- 1452
             +RR  E  +Q +    E  Q   QLE      VELR                       
Sbjct: 263  GVRREYEHFKQHELLSQE--QSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLN 320

Query: 1453 ----QVTQMR-TEESVRYKQSLDDAAKTIQDKNKEIERLKQLID-----KETNDRKCLED 1502
                Q TQ++  E+  R+++  D  ++T+   N  ++              T   + LE 
Sbjct: 321  LCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEA 380

Query: 1503 ENARL---QRVQYDLQKANSSATETINKLKVQEQELTRLRI------DYERVSQER---- 1549
            E  RL   +R   DLQ+ +        +    +Q L    I      + + +  ER    
Sbjct: 381  EEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLV 440

Query: 1550 ---------------------------TVKDQD-ITRFQNSLKELQLQKQKVEEELNRLK 1581
                                          D D + R      ELQ  KQK+    +RLK
Sbjct: 441  DNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLATVQSRLK 500

Query: 1582 RTASED---SCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRD 1638
             +A E    S +     +      + L  Q  ++     Q+E+  +   R+        +
Sbjct: 501  ASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSRPTPLE 560

Query: 1639 VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698
             L+G +   + T + L+ L +E E  +++         +A L       A      +LN 
Sbjct: 561  DLEGRIHSHEGTAQRLQSLGTEKETAQKEC--------EAFLSTRPVGPAALQLPVALNS 612

Query: 1699 SK---IEIERLQSLTENLTKEHLMLEEELRN------------------------LRLEY 1731
             K    +++ L SL     K  L LE ++++                        L+   
Sbjct: 613  VKNKFSDVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERV 672

Query: 1732 DDLRRGRSEADSDKNATILELRSQLQISNNRTLELQG----LINDLQRERENLRQEIEKF 1787
             +L+R R E   ++   +L L   L+ S +    LQ        DL R++  +R   +++
Sbjct: 673  SELQRQRREL-LEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRY 731

Query: 1788 ----------QKQALEASNRIQESKN------------------------QCTQVVQERE 1813
                      +K   +A+   Q+ KN                        Q    +Q ++
Sbjct: 732  HAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQK 791

Query: 1814 SLLVKIKVLEQDKARLQRLEDELNRAKS--TLEAET-----------------RVKQRLE 1854
             L  +I+  E+D+A    L   L  A     L+A+T                 RV    E
Sbjct: 792  RLTQEIQSRERDRATASHLSQALQAALQDYELQADTYRCSLEPTLAVSAPKRPRVAPLQE 851

Query: 1855 CEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQ---------AE 1905
              + Q +N    +    + +++ ++++E  R+    EK  L  +I R           A+
Sbjct: 852  SIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKM--LEKKELSEDIRRTHDAKQGSESPAQ 909

Query: 1906 IKRIEERCRRKLEDSTR---ETQSQLETERS-----RYQREIDKLRQRPYGS-HRETQTE 1956
              R  E  + +LE+  +     Q +LE +RS     R QR +++L ++     +R+ Q E
Sbjct: 910  AGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLE 969

Query: 1957 CEWTVDTSKLVFDGLRK-------KVTAMQLYECQLIDKTTLDKLL-KGKKSVE------ 2002
               +   +++  +G R+       +V A ++ + +   KT    LL K    VE      
Sbjct: 970  GSLSRVKAQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLD 1029

Query: 2003 ----EVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGI 2058
                ++  +IQ  LRG  ++  A          +E  +K+L++ E   + ++ +     +
Sbjct: 1030 SQAAQLRIQIQQ-LRGEDAVISAR---------LEGLKKELLALEKREVDVKEKVVVKEV 1079

Query: 2059 IDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDR 2118
            +   +N ++ V +A A  L   +D  +   AE+A+                 ++  + D 
Sbjct: 1080 VKVEKNLEM-VKAAQALRLQMEEDAARRKQAEEAVA---------------KLQARIEDL 1123

Query: 2119 ETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRD-SQKNFVDPVT 2177
            E  +  +E ++    V        L ++ +  R L++ +  ++    R+ S  +    V 
Sbjct: 1124 ERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSVV 1183

Query: 2178 KKKVSYVQLKERC----RIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTV 2233
            +K+   VQL+ER     +++P T   +  ++ +     G R  V   E     +L    V
Sbjct: 1184 EKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGV---EKEVEKLLPDLEV 1240

Query: 2234 NELESGQISYDEVGERI 2250
               +   + Y EV + +
Sbjct: 1241 LRAQKPTVEYKEVTQEV 1257



 Score = 34.7 bits (78), Expect = 1.4
 Identities = 47/180 (26%), Positives = 75/180 (41%), Gaps = 32/180 (17%)

Query: 2660 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAF--------IGFEGV----KGKKKM 2707
            I+ P TG+ +S  +A  +G+ID+    +L+  +  +         G E V    K  K+ 
Sbjct: 1688 ILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGKQY 1747

Query: 2708 SAAEAV------KEKWLPYEAGQRFL-EFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRA 2760
            S   A+      KE++  Y+ G   + EF  L  G   P     +S    I K  +   A
Sbjct: 1748 SIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPS--SSLSIGSIISKSPLASPA 1805

Query: 2761 AQR-----------LQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVS 2809
             Q            L D S     +    T  K S K A+ ++M++ ITG +LLEA + +
Sbjct: 1806 PQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAAT 1865


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  233 bits (593), Expect = 3e-60
 Identities = 368/1784 (20%), Positives = 706/1784 (39%), Gaps = 357/1784 (20%)

Query: 206  AWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFER 265
            ++G DL  V+  +  H   HN +      L K   D  + S   +L  +Y+ LL AS  R
Sbjct: 153  SFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAK-DGDKEQNS---ELRAKYQKLLAASQAR 208

Query: 266  MDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQ-LEVKEK 324
              HL  LQ+ +Q  + E+ W++   +  + YDWSD+N +   ++  +   +++ LE KE+
Sbjct: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEE 268

Query: 325  ELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKE-NAAYFQFFE 383
             +NKL  E DQL+  +HP  +                      I+ H++  +A + ++  
Sbjct: 269  RINKLHSEGDQLLAAEHPGRNS---------------------IEAHMEAVHADWKEYLN 307

Query: 384  EAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSK 443
                 E++LK ++D                   Q  E  K+ +++L   R+V + +N+  
Sbjct: 308  LLICEESHLKYMED-----------------YHQFHEDVKDAQELL---RKVDSDLNQKY 347

Query: 444  KIVQLKPRNPDYRSNKPI--ILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGV 501
                     PD++    I  +LR L D    +K++ K ++ +++   +R +         
Sbjct: 348  --------GPDFKDRYQIELLLRELDD---QEKVLDKYED-VVQGLQKRGQ--------- 386

Query: 502  DMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIR 561
              +VP       P  P+ V+  C  E   + +++      +   +  SW        K+ 
Sbjct: 387  -QVVPLKYRRETPLKPIPVEALCDFEGE-QGLISRGYSYTLQKNNGESWELMDSAGNKLI 444

Query: 562  AMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQT 621
            A  +  +      + +     L   Y+   + + GS       KR +Q +       Y+ 
Sbjct: 445  APAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS-------KRTLQQR-------YEV 490

Query: 622  LVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEH 681
            L  + PG                                +D Q   +L  L K+   ++ 
Sbjct: 491  LKTENPG------------------------------DASDLQGRQLLAGLDKVASDLDR 520

Query: 682  CEGRMTLKNLPLADQGSSHHITV-KINELKSVQNDSQAIAEVLNQL----KDMLANFRGS 736
             E  +T    P  +QG +   +  +  +LK++ N+   I     +     +  +    GS
Sbjct: 521  QEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGS 580

Query: 737  EKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEET 796
                 L+  V    +K E++  + D     +     L +++ Q+ ++L  +E  L +++T
Sbjct: 581  GTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDT 640

Query: 797  VCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856
            V      +++    L  +  +L  +KSLL  ++  LQ A+Q  S  + ++  +  DL + 
Sbjct: 641  VPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ 700

Query: 857  GEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMK 916
              +V +L  R+  + +Q++ R   L+       ++   +    ++L        S E  +
Sbjct: 701  EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIP----SYEPQE 756

Query: 917  FGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLL 976
                + +   L  QKNL  EI+ +    +EVQKI   CANS + Y+              
Sbjct: 757  TDSLSQMETKLKNQKNLLDEIASRE---QEVQKI---CANS-QQYQ-------------- 795

Query: 977  NIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEV 1036
                             Q   D               Y   +E L+SL DL+        
Sbjct: 796  -----------------QAVKD---------------YELEAEKLRSLLDLE-------- 815

Query: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
                     +  S + +K   L     K + E +   AK   +  + RQ         QN
Sbjct: 816  ---------NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR-------LQN 859

Query: 1097 LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKE----- 1151
            L+     +++  E    +T+E     R    VE+ +  +K   ++ ++ RQ E E     
Sbjct: 860  LEFALNLLRQQPE--VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQ 917

Query: 1152 -------NLGWQKLESEKAIKEK------EYEIERLRVLLQEEGTRKREYENELAKVRNH 1198
                   N G Q+    K + +K      E   ++L+  L EE  + +  + EL  ++  
Sbjct: 918  EEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQ 977

Query: 1199 YNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLND 1258
                    R+  + E  + +    E    + D+   LR +L+ L R+    + E++ L  
Sbjct: 978  LRALEQETRDGGQ-EYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQ 1036

Query: 1259 SILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS-EDNARHKQSLEEAA 1317
             +    E++ RA+E   +++      +Q    LE E +Q+ +    +D  R KQ  EE  
Sbjct: 1037 RVAALAEEKSRAQEKVTEKEVVK---LQNDPQLEAEYQQLQEDHQRQDQLREKQ--EEEL 1091

Query: 1318 KTIQDKNKEIE--RLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKT 1375
              +QDK K +E  R  AE +   K   + E + +  R     E+  L  Q+E E    + 
Sbjct: 1092 SFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATER-----EVSDLTRQYEDEAAKARA 1146

Query: 1376 TIHQLT--------MQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVE 1427
            +  + T        +++E      + ++  + R +     E+  L+  L +     R  E
Sbjct: 1147 SQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAE 1206

Query: 1428 EDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLK 1487
            E ++  ++    + +R  Q+EV  ++VT+    E ++YK        T  +  KE++RL+
Sbjct: 1207 EQLRSYQSELEALRRRGPQVEV--KEVTK----EVIKYK--------TDPEMEKELQRLR 1252

Query: 1488 Q-LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVS 1546
            + ++DK     +C            Y L+K   +  +T  K +VQ +E+           
Sbjct: 1253 EEIVDKTRLIERC--------DLEIYQLKKEIQALKDT--KPQVQTKEVV---------- 1292

Query: 1547 QERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLK 1606
                   Q+I +FQ        +  + +EE+  L+   SE+  K+  LE E       + 
Sbjct: 1293 -------QEILQFQ--------EDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIA 1337

Query: 1607 EQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV----LDGHLREKQRTQEELRRLSSEVE 1662
             +  +++ + +++ Q  +V+   E  LR +       +D  LR+  + + ELRRL     
Sbjct: 1338 RKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRT 1397

Query: 1663 ALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEE 1722
             L RQL +E E  +QA                   E++ E++RLQ     L +E     E
Sbjct: 1398 ELERQL-EELERERQAR-----------------REAEREVQRLQQRLAALEQEEAEARE 1439

Query: 1723 ELRNLR--LEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENL 1780
            ++ + +  +   D ++ R  A          LR QL+   +R   L+G       E E L
Sbjct: 1440 KVTHTQKVVLQQDPQQAREHA---------LLRLQLEEEQHRRQLLEG-------ELETL 1483

Query: 1781 RQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAK 1840
            R+++   +K                   V+E+  L   ++V + D       E E+ R K
Sbjct: 1484 RRKLAALEKAE-----------------VKEKVVLSESVQVEKGDT------EQEIQRLK 1520

Query: 1841 STLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIE 1900
            S+LE E+R K+ L+ E  +++  L++ +   S+  + +  +  E  K + E+ +L+ E  
Sbjct: 1521 SSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETR 1580

Query: 1901 RLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1944
            RLQ+EI       R     +  ++ +  ++     +RE+D L++
Sbjct: 1581 RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKR 1624



 Score =  140 bits (354), Expect = 1e-32
 Identities = 217/995 (21%), Positives = 439/995 (44%), Gaps = 148/995 (14%)

Query: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE---EL 1082
            +L+ + + +  +E+ L+ A+  +S   ++ +    +L++ +AE  +   +  +L    E 
Sbjct: 661  ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER 720

Query: 1083 KRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL 1142
            + Q+    K+A ++  + +  + +    I   +YE + E      +E +   QKN  D++
Sbjct: 721  RAQSLQSAKAAYEHFHRGHDHVLQFLVSIP--SYEPQ-ETDSLSQMETKLKNQKNLLDEI 777

Query: 1143 QKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLL----------------QEEGTRKR 1186
              +R+ E + +     + ++A+K+ E E E+LR LL                Q   T+ +
Sbjct: 778  A-SREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVK 836

Query: 1187 EYENELA-KVRNHYNEEMSNLRN--------KYETEINITKTTIKEISMQKE-DDSKNLR 1236
            E E  LA K    Y      L+N        + + E+ +T  T++        +++  +R
Sbjct: 837  EEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIR 896

Query: 1237 NQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELK 1296
             +LD  +   R L++E+    + I     Q         Q+     E+++K     +E  
Sbjct: 897  KELDEETERRRQLENEVKSTQEEIWTLRNQ-------GPQESVVRKEVLKKVPDPVLEES 949

Query: 1297 QVMQQRSEDNARHK-QSLEEAAKTIQDKNKEIERLKAEFQEE--AKRRWEYENELSKVRN 1353
                QR+    +HK Q L+E  + +Q + + +E+   +  +E   K     E + ++   
Sbjct: 950  FQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADE 1009

Query: 1354 --NYDEEIISLKNQF---ETEINITKTTIHQLTMQK----EEDTSGYRAQIDN---LTRE 1401
                 EE+ +L+ Q    E E+ + +  +  L  +K    E+ T     ++ N   L  E
Sbjct: 1010 VLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAE 1069

Query: 1402 NRSLSEEIKRLKNTLTQTTENLRRVEEDI---QQQKATGSEVSQRKQQLEVELRQVTQMR 1458
             + L E+ +R      +  E L  +++ +   ++++A        K+ L+VE    T+  
Sbjct: 1070 YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATERE 1129

Query: 1459 TEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKAN 1518
              +  R  Q  D+AAK    + ++ E L+++          LE+ENA++           
Sbjct: 1130 VSDLTR--QYEDEAAKARASQREKTELLRKIW--------ALEEENAKVV--------VQ 1171

Query: 1519 SSATETINKLKVQEQELTRLRIDYERVSQERTVK--DQDITRFQNSLKEL-----QLQKQ 1571
                E +      E E+  LR+  E V QER  +  ++ +  +Q+ L+ L     Q++ +
Sbjct: 1172 EKVREIVRPDPKAESEVANLRL--ELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVK 1229

Query: 1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631
            +V +E+ + K T  E   + ++L EE+    R ++   ++I  L ++++     K +   
Sbjct: 1230 EVTKEVIKYK-TDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQV-- 1286

Query: 1632 DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691
               Q ++V+   L+ ++  Q +      EV +LR +L +EQ+  KQ  L  E   +A ++
Sbjct: 1287 ---QTKEVVQEILQFQEDPQTK-----EEVASLRAKLSEEQK--KQVDLERE---RASQE 1333

Query: 1692 KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILE 1751
            +  +  E     E L  + E + ++ ++  EE   LR E        +E+   +   I +
Sbjct: 1334 EQIARKE-----EELSRVKERVVQQEVVRYEEEPGLRAEASAF----AESIDVELRQIDK 1384

Query: 1752 LRSQLQISNNRTLELQGLINDLQRERENLRQ---EIEKFQKQ--ALEASNRIQESKNQCT 1806
            LR++L+    R  EL+  + +L+RER+  R+   E+++ Q++  ALE        K   T
Sbjct: 1385 LRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHT 1444

Query: 1807 QVV-------QERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1859
            Q V       Q RE  L++++ LE+++ R Q LE EL     TL  +    ++ E +++ 
Sbjct: 1445 QKVVLQQDPQQAREHALLRLQ-LEEEQHRRQLLEGELE----TLRRKLAALEKAEVKEKV 1499

Query: 1860 IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1919
            + ++  Q   +    E+ I++++S  E+  R K  L  E+ RL+A +             
Sbjct: 1500 VLSESVQ--VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARL------------- 1544

Query: 1920 STRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1954
                  S+LE   S+  +E+D LR+  +    E Q
Sbjct: 1545 ------SELEFHNSKSSKELDFLREENHKLQLERQ 1573



 Score =  139 bits (351), Expect = 3e-32
 Identities = 352/1781 (19%), Positives = 704/1781 (39%), Gaps = 284/1781 (15%)

Query: 901  WLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNL-HSEISG----------KRDKSEEVQK 949
            W    + + D L +  FG    ++    E+ N+ H+E+            K   SE   K
Sbjct: 138  WAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAK 197

Query: 950  IAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTR 1009
              +L A S +  +  L+S    ++   N      + Q   G +  + +D   R ++  +R
Sbjct: 198  YQKLLAAS-QARQQHLSSLQDYMQRCTNELY--WLDQQAKGRMQYDWSD---RNLDYPSR 251

Query: 1010 SGDYYRFLSEMLKSLED----LKLKNTKIEVLEEELRLARDANSE--NCNKNKFL----- 1058
               Y  F++  L++ E+    L  +  ++   E   R + +A+ E  + +  ++L     
Sbjct: 252  RRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLIC 311

Query: 1059 DQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEI 1118
            +++  KY  +  QF   +   +EL R+ + D       L++ YG   +   +I  L  E+
Sbjct: 312  EESHLKYMEDYHQFHEDVKDAQELLRKVDSD-------LNQKYGPDFKDRYQIELLLREL 364

Query: 1119 EDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLL 1178
            +D+++     ED               +  +K       L+  +    K   +E L    
Sbjct: 365  DDQEKVLDKYED-------------VVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFE 411

Query: 1179 QEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEI----------------NITKTTIK 1222
             E+G   R Y   L K      E M +  NK                     +   +  +
Sbjct: 412  GEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471

Query: 1223 EISMQKEDDSKNLRNQLDRLSRENR-DLKD----EIVRLNDSILQATEQRRRAEENALQQ 1277
             +  +     + L+ + + L  EN  D  D    +++   D +    +++ +A    L+ 
Sbjct: 472  SVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRP 531

Query: 1278 KACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQD-KNKEIERLKAEFQE 1336
                   +Q       +LK +  +         +S  E    IQ         L     E
Sbjct: 532  PLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVE 591

Query: 1337 EAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTI--HQLTMQKEEDTSGYRAQ 1394
            +  R++E+  +L  +     +E + + N+ E  +  +   +  H+  + +++        
Sbjct: 592  DTNRKYEHLLQLLDLA----QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRV 647

Query: 1395 IDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEE--------------DIQQQKATGSEV 1440
            +D+  +E  +++ E++  K+ L +  +NL+  ++              D+++Q+A   ++
Sbjct: 648  LDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKL 707

Query: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQD-------KNKEIERLKQLIDKE 1493
             QR   L  ++ +  Q        Y+         +Q        + +E + L Q+  K 
Sbjct: 708  GQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKL 767

Query: 1494 TNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQE-RTVK 1552
             N +  L++  +R Q VQ               K+    Q+  +   DYE  +++ R++ 
Sbjct: 768  KNQKNLLDEIASREQEVQ---------------KICANSQQYQQAVKDYELEAEKLRSLL 812

Query: 1553 DQDITRFQNSLKELQLQKQ--KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQA- 1609
            D +  R  +  K  +LQ    KV+EE   L    +E     ++  + LE     L++Q  
Sbjct: 813  DLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPE 872

Query: 1610 IKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLL 1669
            +++T+ T Q  +         ++  + R  LD     +++ + E++    E+  LR Q  
Sbjct: 873  VEVTHETLQRNRPD----SGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQ-- 926

Query: 1670 QEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRL 1729
              QESV    +R E  +K  +     L ES  +++R  +L E   K  L L+EEL  L+L
Sbjct: 927  GPQESV----VRKEVLKKVPDPV---LEESFQQLQR--TLAEEQHKNQL-LQEELEALQL 976

Query: 1730 EYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQK 1789
            +   L +     D  +   + E+   L+I  +R    + L          LR+E+E  ++
Sbjct: 977  QLRALEQ--ETRDGGQEYVVKEV---LRIEPDRAQADEVL---------QLREELEALRR 1022

Query: 1790 QALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRV 1849
            Q                +  +E E LL++         R+  L +E +RA+  +  +  V
Sbjct: 1023 Q----------------KGAREAEVLLLQ--------QRVAALAEEKSRAQEKVTEKEVV 1058

Query: 1850 KQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRI 1909
            K         +QND  Q + +Y + +E  ++ +  REK E E + L+ +++RL+ E    
Sbjct: 1059 K---------LQND-PQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA 1108

Query: 1910 EERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFD 1969
            E +   K E    E  +  E E S   R+ +    +   S RE +TE             
Sbjct: 1109 EGKITVK-EVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE-KTE------------- 1153

Query: 1970 GLRKKVTAMQLYECQLIDKTTLDKLLK-GKKSVEEVASEIQPFLRGAGSIAGASASPKEK 2028
             L +K+ A++    +++ +  + ++++   K+  EVA+     +       GA    +  
Sbjct: 1154 -LLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSY 1212

Query: 2029 YSLVEAKRKKLISPESTVMLLEAQAATGGII----DPHRNEKLT------VDSAIARDLI 2078
             S +EA R++   P+     +E +  T  +I    DP   ++L       VD     +  
Sbjct: 1213 QSELEALRRR--GPQ-----VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERC 1265

Query: 2079 DFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPV 2138
            D +    IY  +K I    D             K  +  +E    +L+ Q       DP 
Sbjct: 1266 DLE----IYQLKKEIQALKDT------------KPQVQTKEVVQEILQFQ------EDPQ 1303

Query: 2139 NSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERC------RI 2192
                  ++VA  R  +  +  + ++  R+      + + +K+    ++KER       R 
Sbjct: 1304 TK----EEVASLRAKLSEEQKKQVDLERERASQ-EEQIARKEEELSRVKERVVQQEVVRY 1358

Query: 2193 EPHTGLLL-LSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIK 2251
            E   GL    S    S+  +  +      EL      R     +LE  +       E  +
Sbjct: 1359 EEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAER 1418

Query: 2252 DFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVR-PGTA-------LELLEAQAATGFIVD 2303
            +  +    +A +  E  + +  +    K+ L + P  A       L+L E Q     +  
Sbjct: 1419 EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEG 1478

Query: 2304 PVSNLRLPVEEAYKRGLVGIEFKEKLLSAE--RAVTGYNDPETGNIISLFQAMNKELIEK 2361
             +  LR  +    K      E KEK++ +E  +   G  + E   + S  +  ++   E 
Sbjct: 1479 ELETLRRKLAALEKA-----EVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKREL 1533

Query: 2362 GHGIRLLEAQIATGGIIDPK----------ESHRLPVD---IAYKRGYFNEELSEILSDP 2408
               +  LEA+++     + K          E+H+L ++   +  +      E++   ++ 
Sbjct: 1534 DVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATET 1593

Query: 2409 SD---DTKGFFDPNTEENLTYLQLK----ERCIKDEETGLCLLPLKEKKKQVQTSQKNTL 2461
             D    T      N +  L  L+ +    +R  KD++  +  L  +     V+  Q+   
Sbjct: 1594 RDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENH 1653

Query: 2462 RKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521
             +R +V++ P+T +E+S +EA++ GLID+  F +L  QEC+WEEI++ G +G + V+  D
Sbjct: 1654 LRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVI-HD 1712

Query: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMIS 2562
            RK+G ++ I++A+  G +    +D+Y +  +S+ + A ++S
Sbjct: 1713 RKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVS 1753



 Score = 75.5 bits (184), Expect = 7e-13
 Identities = 127/661 (19%), Positives = 284/661 (42%), Gaps = 108/661 (16%)

Query: 650  NHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINEL 709
            +H +  +   + +++ +++  +L+++ ++    EG++T+K                  E+
Sbjct: 1076 DHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVK------------------EV 1117

Query: 710  KSVQNDS---QAIAEVLNQLKDMLANFRGSEK-YCYLQNEVFGLFQKLENINGVTDGYLN 765
              V+ D+   + ++++  Q +D  A  R S++    L  +++ L +  EN   V      
Sbjct: 1118 LKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEE--ENAKVVVQE--- 1172

Query: 766  SLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 825
                VR +++   + E  +      L E+E       K       L+  +++L   +   
Sbjct: 1173 ---KVREIVRPDPKAESEVANLRLELVEQER------KYRGAEEQLRSYQSELEALRRRG 1223

Query: 826  ATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQI 885
              ++ +    + I  +T    P  + +L +  E++   T    R+ ++ D  ++ L+K+I
Sbjct: 1224 PQVEVKEVTKEVIKYKTD---PEMEKELQRLREEIVDKT----RLIERCDLEIYQLKKEI 1276

Query: 886  KQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSE 945
            + L++ +   Q           ++   E ++F           E      E++  R K  
Sbjct: 1277 QALKDTKPQVQT----------KEVVQEILQF----------QEDPQTKEEVASLRAKLS 1316

Query: 946  EVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIE 1005
            E QK            E Q+A     L  +    +++ +++      L+  A   A  I+
Sbjct: 1317 EEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESID 1376

Query: 1006 LLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKY 1065
            +  R  D  R        L  L+ + T++E   EEL   R A  E   + + L Q L   
Sbjct: 1377 VELRQIDKLR------AELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAAL 1430

Query: 1066 QAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRR 1125
            + E ++ + K+   +++  Q   D + A+++                 L  ++E+E+ RR
Sbjct: 1431 EQEEAEAREKVTHTQKVVLQQ--DPQQAREH---------------ALLRLQLEEEQHRR 1473

Query: 1126 KSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRK 1185
            + +E   +  +     L+KA   EK  L  + ++ EK   + E EI+RL+  L+EE   K
Sbjct: 1474 QLLEGELETLRRKLAALEKAEVKEKVVLS-ESVQVEKG--DTEQEIQRLKSSLEEESRSK 1530

Query: 1186 REYENELAKVRNHYNE-EMSNLRNKYETEINITKTTIKEISMQKED---DSKNLRNQLDR 1241
            RE + E++++    +E E  N  +K   E++  +    ++ +++++   +++ L+++++ 
Sbjct: 1531 RELDVEVSRLEARLSELEFHN--SKSSKELDFLREENHKLQLERQNLQLETRRLQSEINM 1588

Query: 1242 LSRENRDLKDEIV----RLNDSILQATEQ-----RRRAEENALQ----QKACGSEIMQKK 1288
             + E RDL++  V      +DS L + E+     +R +++  L+    QK  GS  ++++
Sbjct: 1589 AATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKRE 1648

Query: 1289 Q 1289
            Q
Sbjct: 1649 Q 1649



 Score = 59.7 bits (143), Expect = 4e-08
 Identities = 160/925 (17%), Positives = 351/925 (37%), Gaps = 143/925 (15%)

Query: 1207 RNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQ 1266
            + KY   +     + KE+S   E   KN         +  +++ D   ++   + +  E 
Sbjct: 10   KGKYSPTVQTRSISNKELSELIEQLQKNA-------DQVEKNIVDTEAKMQSDLARLQEG 62

Query: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDN-ARHKQSLEEAAKTIQDKNK 1325
            R+    +   QK   SE +      +  + + M+    D  A   + L+E    ++ K+K
Sbjct: 63   RQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK 122

Query: 1326 EIERLKAEFQEEAKRRWE--YENELSKVRNNYDEEIISLKNQFETEINITKTTI-----H 1378
            +I RL  + + + +  W    E +L K+ N      + L +    E NI    +     H
Sbjct: 123  QIYRLAVK-EVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPH 181

Query: 1379 QLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS 1438
                  +E  S  RA+   L   +++  + +  L++ + + T  L  +++          
Sbjct: 182  LAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQ---------- 231

Query: 1439 EVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
               Q K +++ +    +    +   R +Q  +   + ++ K + I +L    D+      
Sbjct: 232  ---QAKGRMQYDW---SDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQ------ 279

Query: 1499 CLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
             L  E+     ++  ++  ++   E +N L  +E  L  +               +D  +
Sbjct: 280  LLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYM---------------EDYHQ 324

Query: 1559 FQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ 1618
            F   +K+ Q   +KV+ +LN+      +D  + + L  EL+   + L +    +  L ++
Sbjct: 325  FHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKR 384

Query: 1619 LEQASIVKKRSEDDLR------------QQRDVLDGHLREKQRTQEE------------- 1653
             +Q   +K R E  L+            +Q  +  G+    Q+   E             
Sbjct: 385  GQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLI 444

Query: 1654 ------------------LRRLSSEVEALRRQLLQEQESVKQAH--LRNEHFQKAIEDKS 1693
                                 L S+  ++R++    + +++Q +  L+ E+   A + + 
Sbjct: 445  APAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQG 504

Query: 1694 R----SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE---ADSDKN 1746
            R     L++   +++R +     + +  L     +++      DL+   +E    + +K 
Sbjct: 505  RQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKT 564

Query: 1747 ATILELRSQLQI--SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804
             +  E  + +Q    +  T  L+  + D  R+ E+L Q ++  Q++ ++ +NR+++S  Q
Sbjct: 565  RSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQ 623

Query: 1805 CTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDL 1864
              +++   E+ L +   + +    L     EL      L+A+  +   +E   Q  +   
Sbjct: 624  SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCS 683

Query: 1865 NQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEI---KRIEERCRR------ 1915
            +   +++      + + E+E  K  +  N+LR ++ER    +   K   E   R      
Sbjct: 684  STLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVL 743

Query: 1916 -------KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVF 1968
                     E    ++ SQ+ET+    +  +D++  R     +E Q  C  +    + V 
Sbjct: 744  QFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKICANSQQYQQAVK 799

Query: 1969 DGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ-PFLRGAGSIAGASASPKE 2027
            D           YE +     +L  L  G+ S     + +Q P  +     A  +A   E
Sbjct: 800  D-----------YELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTE 848

Query: 2028 KYSLVEAKRKKLISPESTVMLLEAQ 2052
             Y++    R++L + E  + LL  Q
Sbjct: 849  VYAI---NRQRLQNLEFALNLLRQQ 870



 Score = 33.1 bits (74), Expect = 4.1
 Identities = 21/85 (24%), Positives = 44/85 (51%), Gaps = 7/85 (8%)

Query: 2660 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2719
            +IHP TG++LS ++A   G+ID +M  +L+  +     +E +  K     +  + ++   
Sbjct: 1660 VIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQE---CDWEEISVKGPNGESSVIHDR--- 1713

Query: 2720 YEAGQRFLEFQYLTGGLVDPEVHGR 2744
             ++G++F   + L  G + P  + R
Sbjct: 1714 -KSGKKFSIEEALQSGRLTPAQYDR 1737


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  191 bits (484), Expect = 1e-47
 Identities = 262/1342 (19%), Positives = 590/1342 (43%), Gaps = 146/1342 (10%)

Query: 755  NINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTE--------EETVCLDLDKVEA 806
            N    ++G++   C     ++++   +++ K YEA            E  + L  D V  
Sbjct: 33   NNESSSEGFICPQC-----MKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTL 87

Query: 807  YRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDR 866
             R  ++ ++  L  +K     +K EL+K Q +  Q ++   L           VT  +  
Sbjct: 88   LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGL-----------VTDSSAE 136

Query: 867  WQRIDKQIDFRLWDLEKQIKQLRNYRDNYQA-FCKWLYDAKRRQDSLESMKFGDSNTVMR 925
             Q +++Q++    +    IKQ+++  +   A     + D K + D   S++      V R
Sbjct: 137  LQSLEQQLEEAQTE-NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTR 195

Query: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLL-NIPIKRTM 984
               E   L+ E +  +D   E+     L    I+D  + L      ++TL+ N+ ++R  
Sbjct: 196  LTEE---LNKEATVIQDLKTEL-----LQRPGIEDVAV-LKKELVQVQTLMDNMTLERER 246

Query: 985  ----IQSPSGVILQEAADVHARYIELLTRSGD-------YYRFLSEMLKSLEDLKLKNTK 1033
                ++     +  + A   A   +L +           Y + L ++  S+ +L  KN  
Sbjct: 247  ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306

Query: 1034 I--EVLEEE---LRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAEL 1088
            +   +L++E    +L    N E+ +K K +   L +   +C Q +++L++ E    +  +
Sbjct: 307  LTENLLKKEQDYTKLEEKHNEESVSK-KNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365

Query: 1089 DGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQK---- 1144
            +     +   K   ++ E+  K   L  E +  +++R+  E    Q +++ +QL      
Sbjct: 366  ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE 425

Query: 1145 ---------ARQCEKENLGWQKL-ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194
                      R  E+  L  +KL + E+ + + + ++ RL   L+E+ T   E +++L K
Sbjct: 426  TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK 485

Query: 1195 VRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIV 1254
             +  + E+ + L+     ++   +  ++++  Q  D  + ++N L+ L +++++      
Sbjct: 486  TKQQHQEQQA-LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN-LEALLQKSKE------ 537

Query: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQH-LEIELKQVMQQRSEDNARHKQSL 1313
              N S+L+   +   A+  A + +      +Q+K H L+ ++ Q+ ++    +  HKQ+ 
Sbjct: 538  --NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 1314 EEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINIT 1373
            E     +Q++   +       Q+         NEL+   N   E++  L  Q + +  + 
Sbjct: 596  ENLHDQVQEQKAHLRAA----QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELL 651

Query: 1374 KT-----TIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEE 1428
             +     T  +  +Q   DT+  +  + +  +E   ++ ++ ++   L    E+  ++E 
Sbjct: 652  LSAEAAKTAQRADLQNHLDTA--QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709

Query: 1429 DIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQ 1488
             +++ K     + Q+ ++LE +++++     E     +Q+L D  +  Q  N ++E    
Sbjct: 710  HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ-LNTDLEL--- 765

Query: 1489 LIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQE 1548
               + T   K LE E   +   + DLQK + +      KL  QE+E   L+ D+E +SQE
Sbjct: 766  ---RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822

Query: 1549 RTVKDQDIT-RFQNSLKELQ---LQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRS 1604
              ++ +++  R Q ++ ELQ   ++K+ +  EL+ +K   S+ S   K  + E E   + 
Sbjct: 823  TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882

Query: 1605 LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664
             K   + +    ++L+    ++ + E+ L++Q+++     +EK+ + +    L  E+ ++
Sbjct: 883  GKAAILDLEKTCKELKHQ--LQVQMENTLKEQKELKKSLEKEKEASHQ----LKLELNSM 936

Query: 1665 RRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEEL 1724
            + QL+Q Q ++KQ     +  Q  I +  +S  + K +IE LQ   +    +   LE +L
Sbjct: 937  QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKL 996

Query: 1725 RNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEI 1784
            +        L +   E  ++K   I  L++  + S     +LQ      + E    RQ++
Sbjct: 997  QQ------QLTQAAQELAAEKEK-ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDL 1049

Query: 1785 EKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLE 1844
            +  +++   A   +  ++NQ     +  + L      LEQD A+ ++   E  +A   ++
Sbjct: 1050 KSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQ 1109

Query: 1845 AETRVKQR--------------LECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSE- 1889
             E  +K++              ++C +++    LN+     S K E+I++I + ++  + 
Sbjct: 1110 KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE--ELKSHKLESIKEITNLKDAKQL 1167

Query: 1890 --REKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREI-DKLRQRP 1946
              ++K  L+ + + L+A +++ E+R ++ L+D  ++ + +L+ E    + ++  +++++ 
Sbjct: 1168 LIQQKLELQGKADSLKAAVEQ-EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226

Query: 1947 YGSHRETQTECEWTVDTSKLVFD-GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA 2005
             G  +  + E + T+  + L  + G  KK           ++K T D  L+G+ +V E  
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD--LRGEIAVLEAT 1284

Query: 2006 SE---------IQPFLRGAGSI 2018
             +         ++  L+G G I
Sbjct: 1285 VQNNQDERRALLERCLKGEGEI 1306



 Score =  161 bits (407), Expect = 1e-38
 Identities = 247/1301 (18%), Positives = 526/1301 (40%), Gaps = 205/1301 (15%)

Query: 663  KQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEV 722
            K+E W   EL+K   ++E  +G    +  P    G     + ++  L+    ++Q     
Sbjct: 100  KEEKWYSEELKK---ELEKYQGLQQQEAKP---DGLVTDSSAELQSLEQQLEEAQTENFN 153

Query: 723  LNQLKDMLANFRGSEKYCYLQNEVFGLFQKLEN-----------INGVTDGYLNSLCTVR 771
            + Q+KD+       +K   L  E+  +  K +            +  +T+        ++
Sbjct: 154  IKQMKDLF-----EQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQ 208

Query: 772  ALLQAILQTEDM--LKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMK 829
             L   +LQ   +  + V +  L + +T+ +D   +E  R   +K+K++    +S  A+ +
Sbjct: 209  DLKTELLQRPGIEDVAVLKKELVQVQTL-MDNMTLERERES-EKLKDECKKLQSQYASSE 266

Query: 830  TELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLR 889
              + + +   ++  Q+  +Y  +L K    V +LT + Q + + +          +K+ +
Sbjct: 267  ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL----------LKKEQ 316

Query: 890  NYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQK 949
            +Y    +   +     K  Q +L            R    + +LH       +K E  QK
Sbjct: 317  DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376

Query: 950  IAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTR 1009
            + E  +     Y+   A +         +  +R   +     +  E   +H++ +E   +
Sbjct: 377  LKEELSEVETKYQHLKAEFKQ-------LQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429

Query: 1010 SGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR------DANSENCNKNKFLDQNLQ 1063
             G+ +  L E  + L   KL + + +V + +L+L+R      +  + +      LD+  Q
Sbjct: 430  LGEAHGRLKEQ-RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 488

Query: 1064 KYQAECSQFKAKLASLEELKRQAE-----LDGKSAK-QNLDKCYGQIKE----------- 1106
            ++Q + +  ++  A L E +   E     +  K  K QNL+    + KE           
Sbjct: 489  QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548

Query: 1107 ------------------------LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL 1142
                                    L E++T+LT +++++    K  ++    Q  +    
Sbjct: 549  LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608

Query: 1143 QKARQ-------CEKENLGWQKLESEKAIKEKEYEIE-RLRVLLQEEGTR---KREYENE 1191
             +A Q            L  Q  ES++ + + + +I+ +  +LL  E  +   + + +N 
Sbjct: 609  LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNH 668

Query: 1192 LAKVRNHYNEEMSNLRNKYETEINITKTTIK---EISMQKEDDSKNLRNQLDRLSRENRD 1248
            L   +N   ++   L NK  T+++     ++   E   Q E   K  + +   L ++  +
Sbjct: 669  LDTAQNALQDKQQEL-NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE 727

Query: 1249 LKDEIVRLNDSILQATEQRRRAEENALQQKACGSEI------------------------ 1284
            L+ +I +L    L+    + +A ++  QQ+   +++                        
Sbjct: 728  LEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLD 787

Query: 1285 MQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIE-RLKAEFQEEAKRRWE 1343
            +QKK      +KQ + ++ E+    KQ  E  ++  + +++E+  R++    E  K + E
Sbjct: 788  LQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKME 847

Query: 1344 YE---NELSKVRNNYDEEIISLKN---QFETEINITKTTI-----------HQLTMQKEE 1386
             E    ELS V++   +   SLKN   +FE E    K  I           HQL +Q E 
Sbjct: 848  KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907

Query: 1387 DTSGYRAQIDNLTRENR----------SLSEEIKRLKNTLTQTTENLRRVEEDIQQQKAT 1436
                 +    +L +E            S+ E++ + +NTL Q  +  ++++ +I + K +
Sbjct: 908  TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967

Query: 1437 GSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETND 1496
              +  ++ + L+ EL+     +TE   + +Q L  AA+ +  + ++I  L+   +K    
Sbjct: 968  SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027

Query: 1497 RKCLEDE-----------NARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERV 1545
             K L+ +              L+ V+  L  A        N++  Q + +  L+     +
Sbjct: 1028 FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087

Query: 1546 SQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSL 1605
             Q+   K+Q +     +L+++Q +K   E+EL   K   +E    + + E+E+  +   L
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147

Query: 1606 KEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELR-RLSSEVEAL 1664
            K   ++       L+ A  +  + + +L+ + D L   + +++R Q+ L+ ++  E E L
Sbjct: 1148 KSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207

Query: 1665 RRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEEL 1724
            +++ ++     K+A L +E  +K +  K    NE+K            LT +   L E L
Sbjct: 1208 KKEFIE-----KEAKLHSEIKEKEVGMKKHEENEAK------------LTMQITALNENL 1250

Query: 1725 RNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQ-- 1782
              ++ E+   +R  SE +   +    +LR ++ +       L+  + + Q ER  L +  
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTD----DLRGEIAV-------LEATVQNNQDERRALLERC 1299

Query: 1783 -----EIEKFQKQALEASNRIQESKNQCTQVVQERESLLVK 1818
                 EIEK Q + LE   ++  +     ++ +E +SL +K
Sbjct: 1300 LKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1340



 Score =  143 bits (361), Expect = 2e-33
 Identities = 242/1161 (20%), Positives = 481/1161 (41%), Gaps = 131/1161 (11%)

Query: 603  DDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITH-HGTCQDVNHNKVIETNREN 661
            D+ +K+QSQ+  ++     L  +L   PQ   V   E+     +  ++       T    
Sbjct: 253  DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLL 312

Query: 662  DKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAE 721
             K++ +  +E +     +     + TL    L  Q     ++     L  +  +     E
Sbjct: 313  KKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGE 372

Query: 722  VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTE 781
               +LK+ L+      KY +L+ E   L Q+ E         L     +  L   +L+TE
Sbjct: 373  ATQKLKEELSEV--ETKYQHLKAEFKQLQQQREE---KEQHGLQLQSEINQLHSKLLETE 427

Query: 782  DMLKVYEARLTEEETVCLD--LDK---VEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQ 836
              L     RL E+  +  +  +DK   V   +  L +++  L  K +    ++ +L K +
Sbjct: 428  RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 487

Query: 837  QIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQ 896
            Q H    +Q  L      K  E    L    +++ +QI  +   ++     L+  ++N  
Sbjct: 488  QQH---QEQQALQQSTTAKLREAQNDL----EQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 897  AFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCAN 956
                     K R+D    ++ G+  T +    ++KN            E+V ++ E   N
Sbjct: 541  LL------EKEREDLYAKIQAGEGETAVLNQLQEKN--------HTLQEQVTQLTEKLKN 586

Query: 957  SIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRF 1016
                   Q  S+    E L         +Q      L+ A D   R + L T   +    
Sbjct: 587  -------QSESHKQAQENL------HDQVQEQK-AHLRAAQD---RVLSLETSVNELNSQ 629

Query: 1017 LSEMLKSLEDLKLK---NTKIEVLEEELRLARDANSEN---CNKNKFLD--QNLQKYQAE 1068
            L+E  + +  L ++    T++ +  E  + A+ A+ +N     +N   D  Q L K   +
Sbjct: 630  LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689

Query: 1069 CSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYE-IEDEKRRRKS 1127
              Q  AKL   +E   Q E   K  K+       + +EL  +I +L  + +E +  + ++
Sbjct: 690  LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749

Query: 1128 VEDRFDQQKNDYD------QLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEE 1181
            ++D   Q++ + D      +L K  + EKE +   +L+ +K  +  E   ++L    +E+
Sbjct: 750  LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809

Query: 1182 GTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK----TTIKEISMQKEDDSK---N 1234
               K+++E  L++     +EE++N      TE+   K      + E+S  K+  SK   +
Sbjct: 810  QILKQDFET-LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868

Query: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENAL-QQKACGSEIMQKKQ---H 1290
            L+N      +EN+  K  I+ L  +  +   Q +   EN L +QK     + ++K+    
Sbjct: 869  LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 928

Query: 1291 LEIELKQVMQQ------RSEDNARHKQSLE----EAAKTIQDKNKEIERLKAEFQEEAKR 1340
            L++EL  + +Q        + N + +Q L+    E  ++ + K K+IE L+ E +    +
Sbjct: 929  LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQ 988

Query: 1341 RWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTR 1400
            + E EN+L +      +E+ + K          K ++ Q   +K ++T   + Q D   R
Sbjct: 989  KTELENKLQQQLTQAAQELAAEKE---------KISVLQNNYEKSQETF-KQLQSDFYGR 1038

Query: 1401 ENRSLS--EEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMR 1458
            E+  L+  +++K ++  L+   E+L      I  Q     E+   K  LE          
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE---------- 1088

Query: 1459 TEESVRYKQSLDDAAKTIQDKNKEIE-RLKQLIDK-----ETNDRKCLEDENARLQRVQY 1512
             ++S + +Q L +  K +QD  KE   + K+L+++     E  + KC +++   + ++  
Sbjct: 1089 -QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK--EITKLNE 1145

Query: 1513 DLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQK 1572
            +L+     + + I  LK  +Q L + +++ +  +       +   R Q  LK+   Q +K
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD---QVKK 1202

Query: 1573 VEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKK----- 1627
             EEEL   K    +++    +++E+  GM++  + +A     +T   E    VKK     
Sbjct: 1203 EEEELK--KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSS 1260

Query: 1628 -RSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQ 1686
             R   +L +Q D L G +   + T   ++    E  AL  + L+ +  +++   +    Q
Sbjct: 1261 QRRVSELEKQTDDLRGEIAVLEAT---VQNNQDERRALLERCLKGEGEIEKLQTKVLELQ 1317

Query: 1687 KAIEDKSRSLNESKIEIERLQ 1707
            + +++ + ++ E   E + LQ
Sbjct: 1318 RKLDNTTAAVQELGRENQSLQ 1338



 Score =  102 bits (253), Expect = 7e-21
 Identities = 156/862 (18%), Positives = 357/862 (41%), Gaps = 116/862 (13%)

Query: 1413 KNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE---------SV 1463
            ++ L    +++  + +++Q  +A+  E     ++L+ EL +   ++ +E         S 
Sbjct: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 1464 RYKQSLDDAAKTIQDKNKEIERLKQLIDK-------ETNDRKCLEDENARLQRVQYDLQK 1516
               QSL+   +  Q +N  I+++K L ++       E  D K   DE   L+      ++
Sbjct: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA---EQ 191

Query: 1517 ANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEE 1576
              +  TE +NK     Q+L    +    +     +K +++ + Q  +  + L++++  E+
Sbjct: 192  KVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLK-KELVQVQTLMDNMTLERERESEK 250

Query: 1577 LNRLKRTASEDSCKRKKL-----EEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631
            L        +D CK+ +      E  +  +R  L +   ++    Q+L++     K S +
Sbjct: 251  L--------KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL----KSSVN 298

Query: 1632 DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691
            +L Q+   L  +L +K++   +L    +E    ++ +   Q ++ Q  L  +  Q  +  
Sbjct: 299  ELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI---QATLHQKDLDCQQLQSRLSA 355

Query: 1692 KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEAD--------- 1742
               SL+   +E+      T+ L +E   +E + ++L+ E+  L++ R E +         
Sbjct: 356  SETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSE 415

Query: 1743 -SDKNATILE-----------LRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQ 1790
             +  ++ +LE           L+ Q Q+S+ + ++ +  + DLQ +   L +++++    
Sbjct: 416  INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN 475

Query: 1791 ALEASNRIQESKNQCTQVVQERESLLVKIKVLEQD-----------KARLQRLEDELNRA 1839
            + E  +++ ++K Q  +    ++S   K++  + D             ++Q LE  L ++
Sbjct: 476  STELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 535

Query: 1840 KSTLEAETRVKQRLECEKQQIQND---LNQWKTQYSRKEEAI----RKIESEREKSEREK 1892
            K  +    + ++ L  + Q  + +   LNQ + +    +E +     K++++ E  ++ +
Sbjct: 536  KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 1893 NSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1952
             +L  +++  +A ++  ++R    LE S  E  SQL   + +  +   +++ +   +   
Sbjct: 596  ENLHDQVQEQKAHLRAAQDRV-LSLETSVNELNSQLNESKEKVSQLDIQIKAK---TELL 651

Query: 1953 TQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTT-LDKLLKGKKSVEEVASEIQPF 2011
               E   T   + L  + L     A+Q  + +L   TT LD++    +  +E  S+++  
Sbjct: 652  LSAEAAKTAQRADLQ-NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESH 710

Query: 2012 LRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDS 2071
            L+            KEKY  +E K ++L   E  +  LEA +           + L    
Sbjct: 711  LK----------EYKEKYLSLEQKTEEL---EGQIKKLEADSLEVKASKEQALQDLQQQR 757

Query: 2072 AIARDL-IDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIA 2130
             +  DL +   +  +    EK I         K     E+IK+ L  +E   ++L+    
Sbjct: 758  QLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFE 817

Query: 2131 S----------------GGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDP-RDSQKNFV 2173
            +                   V  +  V + K+  +      +D    ++D  ++S+  F 
Sbjct: 818  TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877

Query: 2174 DPVTKKKVSYVQLKERCRIEPH 2195
                K K + + L++ C+   H
Sbjct: 878  KENQKGKAAILDLEKTCKELKH 899



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 234/1176 (19%), Positives = 472/1176 (40%), Gaps = 164/1176 (13%)

Query: 231  YRWQLDKIKADLREKSAIYQLEEEYENLLKAS--FERMDHLRQLQNIIQATSREIMWIND 288
            Y  +L K+K+ + E +   Q   E  NLLK    + +++     +++ +   +  +   D
Sbjct: 286  YVQELQKLKSSVNELTQKNQTLTE--NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD 343

Query: 289  CEEEELLYDWSDKNTNI-------AQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQH 341
             + ++L    S   T++       ++K EA      +L   E +   LK E  QL     
Sbjct: 344  LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL----- 398

Query: 342  PASDKIEAYMDTLQTQWSWILQI-TKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIR 400
                + E     LQ Q S I Q+ +K ++   +   A+ +  E+ Q +   L   +  + 
Sbjct: 399  -QQQREEKEQHGLQLQ-SEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV- 455

Query: 401  KKYPCDKNMPLQHLLEQIKE-------LEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP 453
                 D  + L  L EQ+KE       L+ + +K  +  ++ Q L  +     +L+    
Sbjct: 456  ----ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL--QQSTTAKLREAQN 509

Query: 454  DYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIP 513
            D       +LR + D  +DQKI +   E +L+ + E           + +L         
Sbjct: 510  DLEQ----VLRQIGD--KDQKIQNL--EALLQKSKEN----------ISLLEKE------ 545

Query: 514  PPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQ 573
                   DL  KI Q  E   A+ NQL     +L          E++  +T  KLK  + 
Sbjct: 546  -----REDLYAKI-QAGEGETAVLNQLQEKNHTLQ---------EQVTQLT-EKLKN-QS 588

Query: 574  EDYMKTIADLELHYQE---FIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYP 630
            E + +   +L    QE    +R +Q   +  +    ++ SQ  ++++    L IQ+    
Sbjct: 589  ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648

Query: 631  Q-------HQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHC- 682
            +        +T    ++ +H    D   N + +  +E +K  T +     K++ + EHC 
Sbjct: 649  ELLLSAEAAKTAQRADLQNH---LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705

Query: 683  ----------EGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLAN 732
                      E  ++L+      +G    +     E+K+ +  +    +   QL   L  
Sbjct: 706  QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL-E 764

Query: 733  FRGSE--KYCYLQNEVFGLFQ-KLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEA 789
             R +E  K   ++ E+    +  L+  +   +     L       Q + Q  + L   E 
Sbjct: 765  LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS-QET 823

Query: 790  RLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLY 849
            ++  EE      ++++     L+K+K +     + L+T+K +L K       +  ++   
Sbjct: 824  KIQHEELN----NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF--- 876

Query: 850  DLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQ 909
            + +  K    +  L    + +  Q+  ++ +  K+ K+L+   +  +     L   K   
Sbjct: 877  EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL---KLEL 933

Query: 910  DSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969
            +S++       NT+ +   E++ L   I+  +  SE+ +K  E     +K   LQ     
Sbjct: 934  NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993

Query: 970  SGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL 1029
            + L+  L    +    +     +LQ   +      + L    D+Y   SE+L + +DLK 
Sbjct: 994  NKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL--QSDFYGRESELLATRQDLKS 1051

Query: 1030 KNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAK--------LASLEE 1081
               K+ + +E+L   R+      N+NK + Q L+  +A   Q  AK          +L++
Sbjct: 1052 VEEKLSLAQEDLISNRNQIG---NQNKLI-QELKTAKATLEQDSAKKEQQLQERCKALQD 1107

Query: 1082 LKRQAELDGKSAKQNLDKCYGQIKELN----EKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137
            ++++  L  K       K   +I+E+     ++IT+L  E++  K       +   +  N
Sbjct: 1108 IQKEKSLKEKELVNEKSKL-AEIEEIKCRQEKEITKLNEELKSHKL------ESIKEITN 1160

Query: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRV--LLQEEGTRKREYENELAKV 1195
              D  Q   Q + E  G  K +S KA  E+E   +++    + +EE   K+E+  + AK+
Sbjct: 1161 LKDAKQLLIQQKLELQG--KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218

Query: 1196 RNHYNEEMSNLRNKYETEINITK--TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEI 1253
             +   E+   ++   E E  +T   T + E     + + ++ + ++  L ++  DL+ EI
Sbjct: 1219 HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEI 1278

Query: 1254 VRLNDSILQATEQRRRAEENALQQKAC-GSEIMQKKQHLEIELKQVMQQRSEDNARHKQS 1312
                 ++L+AT Q  + E  AL ++   G   ++K Q   +EL++               
Sbjct: 1279 -----AVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQR--------------K 1319

Query: 1313 LEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENEL 1348
            L+     +Q+  +E + L+ +  +   R+W  +NE+
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1355



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 172/881 (19%), Positives = 342/881 (38%), Gaps = 152/881 (17%)

Query: 220  SHRGIHNSIGDYRWQLDKIKADLRE-KSAIYQLEEEYENLLKASFERMDHLRQLQNIIQA 278
            SH+    ++ D   Q+ + KA LR  +  +  LE     L     E  + + QL   I+A
Sbjct: 590  SHKQAQENLHD---QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646

Query: 279  TSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQL-- 336
             +           E LL   + K    A  Q       + L+ K++ELNK+  + DQ+  
Sbjct: 647  KT-----------ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695

Query: 337  -VLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGL 395
             + ++     ++E+++   + ++  + Q T+ ++  +K+  A     E   S E  L+ L
Sbjct: 696  KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA--DSLEVKASKEQALQDL 753

Query: 396  QDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDY 455
            Q   +++   D  +      E  K+LE E+E +   +  +Q    KS+ +  +K +    
Sbjct: 754  QQ--QRQLNTDLEL---RATELSKQLEMEKEIVSSTRLDLQ---KKSEALESIKQKLTKQ 805

Query: 456  RSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPP 515
               K I+ +      Q+ KI H       ++ N R +  VT    V M            
Sbjct: 806  EEEKQILKQDFETLSQETKIQH-------EELNNRIQTTVTELQKVKM----------EK 848

Query: 516  NPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQED 575
              L  +LS   ++  +   +L N      K        ++D+EK    T  +LK   Q  
Sbjct: 849  EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK----TCKELKHQLQVQ 904

Query: 576  YMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQ---KHYQTLVIQLPGYPQH 632
               T+ + +   +   +  + S      +   +Q Q   AQ   K  +    QL G    
Sbjct: 905  MENTLKEQKELKKSLEKEKEASHQL-KLELNSMQEQLIQAQNTLKQNEKEEQQLQG---- 959

Query: 633  QTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLP 692
                             N N++ +++ +  KQ   +  EL+    Q    E ++  +   
Sbjct: 960  -----------------NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002

Query: 693  LADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQK 752
             A +     +  +  ++  +QN+ +   E   QL+   ++F G E      +E+    Q 
Sbjct: 1003 AAQE-----LAAEKEKISVLQNNYEKSQETFKQLQ---SDFYGRE------SELLATRQD 1048

Query: 753  LENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAY---RC 809
            L+++          L + R       Q  +  K+ +   T + T+  D  K E     RC
Sbjct: 1049 LKSVEEKLSLAQEDLISNRN------QIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102

Query: 810  -GLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQ 868
              L+ I+ + +LK+  L   K++L + ++I  +  ++              +T+L +   
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKE--------------ITKLNE--- 1145

Query: 869  RIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLN 928
                  + +   LE  IK++ N +D  Q   +   + + + DSL++    +        +
Sbjct: 1146 ------ELKSHKLE-SIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD 1198

Query: 929  EQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSP 988
            + K    E+     K E ++K A+L  + IK+ E+ +  +    E    + ++ T +   
Sbjct: 1199 QVKKEEEEL-----KKEFIEKEAKL-HSEIKEKEVGMKKHE---ENEAKLTMQITALNEN 1249

Query: 989  SGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN 1048
             G + +E      R              +SE+ K  +DL+ +   +E   +  +  R A 
Sbjct: 1250 LGTVKKEWQSSQRR--------------VSELEKQTDDLRGEIAVLEATVQNNQDERRAL 1295

Query: 1049 SENCNKNKFLDQNLQKYQAECSQFKAKL----ASLEELKRQ 1085
             E C K    +  ++K Q +  + + KL    A+++EL R+
Sbjct: 1296 LERCLKG---EGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  188 bits (478), Expect = 6e-47
 Identities = 235/994 (23%), Positives = 431/994 (43%), Gaps = 129/994 (12%)

Query: 1019 EMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKA---- 1074
            E  + L + + ++ K E LE+  R  RD   E   + +   Q  ++ +AE  Q ++    
Sbjct: 143  EQERELAEGEEQSEKQERLEQRDRQRRD---EELWRQRQEWQEREERRAEEEQLQSCKGH 199

Query: 1075 ---KLASLEELKRQAELD----GKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKS 1127
               +    E+L+R+  L+    G+  KQ         ++  E+  R+  E E+++ R++ 
Sbjct: 200  ETEEFPDEEQLRRRELLELRRKGREEKQ---------QQRRERQDRVFQEEEEKEWRKRE 250

Query: 1128 VEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKRE 1187
               R +++K   ++ Q+ R+ ++E    +KLE ++  +E++ E ++ + L +E+  R+++
Sbjct: 251  TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310

Query: 1188 YEN--ELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRE 1245
             E   E  + R    E       + E ++   +   +E  +++E + +    QL R   E
Sbjct: 311  EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370

Query: 1246 NRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHL--EIELKQVMQQRS 1303
             R          +  L+  +Q RR ++   +Q+    + ++++Q L  E +L++  Q R 
Sbjct: 371  ER---------REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421

Query: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLK 1363
            E   R +Q  E   +  + + +E +RLK E  +E +R W                   LK
Sbjct: 422  EQQLRREQEEERHEQKHEQERRE-QRLKRE--QEERRDW-------------------LK 459

Query: 1364 NQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENL 1423
             + ETE +  +    QL   +EE+      +++   R  +    E +  +    +  + L
Sbjct: 460  REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519

Query: 1424 RRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEI 1483
            +R EE+               ++L+  LR   Q+R E+  R +Q L    K  ++K  E 
Sbjct: 520  KRQEEE---------------ERLQQRLRSEQQLRREQEERREQLL----KREEEKRLEQ 560

Query: 1484 ERLKQLIDKETNDRK---CLEDENARLQRVQYDL-----QKANSSATETINKLKVQEQEL 1535
            ER +Q + +E  +R+      +E  R QR++ +      Q+      E + + + +EQ L
Sbjct: 561  ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620

Query: 1536 TRLRIDYERVSQ------ERTVKDQDITRFQNSLKELQLQKQKVEEEL-NRLKRTASEDS 1588
             R   + ER  Q      +   + Q + R Q   +E +L++++ EE L  RLKR   E+ 
Sbjct: 621  KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680

Query: 1589 CKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQ----QRDVLDGHL 1644
             +++  EEE E  R  +K    +I     QLE        SE D RQ     R       
Sbjct: 681  REQELAEEEQEQARERIKS---RIPKWQWQLE--------SEADARQSKVYSRPRKQEGQ 729

Query: 1645 REKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIE 1704
            R +Q  +E+ RR  SE++    +    Q+  ++   R+  +Q   E+KS    +      
Sbjct: 730  RRRQEQEEKRRRRESELQWQEEERAHRQQQ-EEEQRRDFTWQWQAEEKSERGRQRLSARP 788

Query: 1705 RLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTL 1764
             L+   E   +     + E R L  E +  +R R   + +K    LE   QLQ    R  
Sbjct: 789  PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ-RRERAQ 847

Query: 1765 ELQGLINDLQRERENLR--------------QEIEKFQKQALEASNRIQESKNQCTQVVQ 1810
            +LQ   + LQ ++E  R              +E  K ++  L A   +QE   +  Q++Q
Sbjct: 848  QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907

Query: 1811 ERESLL---VKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLN-Q 1866
            E E  L    + K   Q++ R  R E++L + +  L  E R K+R +  ++Q + D   Q
Sbjct: 908  EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K +    EE  ++   EREK  RE+  L+ E E+L  E +    R   + +   ++   
Sbjct: 968  QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027

Query: 1927 QLETERSRYQREIDKL--RQRPYGSHRETQTECE 1958
            Q E +  R +RE  +L  R+R Y    E Q E E
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061



 Score =  183 bits (465), Expect = 2e-45
 Identities = 231/985 (23%), Positives = 449/985 (45%), Gaps = 111/985 (11%)

Query: 1029 LKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAEL 1088
            L+  + ++ EEE +  R+   E     K   Q L++ + E  Q + +L   ++L+R+ E 
Sbjct: 253  LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312

Query: 1089 DGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQ---KNDYDQLQKA 1145
            + +  ++                     E  +++ RR+  E+R +QQ   + +  + Q+ 
Sbjct: 313  ERREQQE---------------------ERREQQERREQQEERREQQLRREQEERREQQL 351

Query: 1146 RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY---ENELAKVRNHYNEE 1202
            R+ ++E    Q+L  E+  + +E ++ R + L +E+  R+ +    E +L + +    E+
Sbjct: 352  RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411

Query: 1203 MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQ 1262
                  +   E  + +   +E   QK +  +  R Q  RL RE  + +D + R  ++  +
Sbjct: 412  QLRREQQLRREQQLRREQEEERHEQKHEQER--REQ--RLKREQEERRDWLKREEET--E 465

Query: 1263 ATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQD 1322
              EQ RR ++    Q+    E  ++   LE E ++  Q+R E   R +Q  EE  +    
Sbjct: 466  RHEQERRKQQLKRDQE---EERRERWLKLEEEERREQQERREQQLRREQ--EERREQRLK 520

Query: 1323 KNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTM 1382
            + +E ERL+   + E + R E E    ++    +E+ +  + + E  +   +       +
Sbjct: 521  RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR-EQRLKREQEERRDQLL 579

Query: 1383 QKEEDTSGYRAQIDNLTR-ENRSLSEEIKRLKNTLTQTTENLRRVE--EDIQQQKATGSE 1439
            ++EE+    R + +   R E R   EE++RL+    +  + L+R E  E+ +QQ     E
Sbjct: 580  KREEERRQQRLKREQEERLEQRLKREEVERLEQE-ERREQRLKREEPEEERRQQLLKSEE 638

Query: 1440 VSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKC 1499
              +R+QQ   +LR+  Q R E+ ++ ++  +   + ++ +++E  R ++L ++E    + 
Sbjct: 639  QEERRQQ---QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR- 694

Query: 1500 LEDENARLQRVQYDLQ-KANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558
             E   +R+ + Q+ L+ +A++  ++  ++ + QE +  R   + +R  +E  ++ Q+  R
Sbjct: 695  -ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753

Query: 1559 FQNSLKELQLQKQ-----KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAI--- 1610
                 +E + ++      + EE+  R ++  S     R++ E +L    R  +EQ     
Sbjct: 754  AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813

Query: 1611 -------------KITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELR-- 1655
                         +   L    E+  + ++     L+++ D L    +E++R+QE+ R  
Sbjct: 814  EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED-QERRRSQEQRRDQ 872

Query: 1656 --RLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENL 1713
              R   E E  RR+     +   Q  LR E  Q+ ++++   L   + E  R Q      
Sbjct: 873  KWRWQLEEERKRRRHTLYAKPALQEQLRKE--QQLLQEEEEELQREEREKRRRQEQERQY 930

Query: 1714 TKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL---QISNNRTLELQGLI 1770
             +E  + +EE + LR E +  RR   E    K+  + +   QL   +    R  E +   
Sbjct: 931  REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990

Query: 1771 ND---LQRERENL-RQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826
             +   LQ+E E L R+E EK ++Q  E   R ++      ++ QE E LL +    E++K
Sbjct: 991  REEEELQQEEEQLLREEREKRRRQEWERQYRKKD------ELQQEEEQLLRE----EREK 1040

Query: 1827 ARLQ------RLEDELNRAKSTL---EAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEA 1877
             RLQ      R E+EL + +  L   E ETR +Q LE + ++ + +L Q + Q  R+E  
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK-EEELQQEEEQLLREEPE 1099

Query: 1878 IRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQR 1937
             R+   ERE+  RE+  L+ E E+L  E +  E+R R++LE   RE +   + E    + 
Sbjct: 1100 KRR-RQERERQCREEEELQQEEEQLLREER--EKRRRQELERQYREEEEVQQEEEQLLRE 1156

Query: 1938 EIDKLR----QRPYGSHRETQTECE 1958
            E +K R    +R Y    E Q E E
Sbjct: 1157 EPEKRRRQELERQYREEEELQQEEE 1181



 Score =  173 bits (439), Expect = 2e-42
 Identities = 230/1021 (22%), Positives = 446/1021 (43%), Gaps = 125/1021 (12%)

Query: 1025 EDLKLKNTKIEVLEEELRLARDANSEN-CNKNKFLDQNLQKYQAECSQFKAKLASLEELK 1083
            E+ +L+  + ++L EE    R    E    K+K L Q  ++   E  + + +    ++ +
Sbjct: 932  EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991

Query: 1084 RQAELDG-----------KSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRF 1132
             + EL             K  +Q  ++ Y +  EL ++  +L  E E EKRR +  E ++
Sbjct: 992  EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE-EREKRRLQERERQY 1050

Query: 1133 DQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY---- 1188
             +++    + ++    E+E    Q+LE +   KE+E + E  ++L +E   R+R+     
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYR-KEEELQQEEEQLLREEPEKRRRQERERQ 1109

Query: 1189 ---ENELAKVRNHYNEEMSNLRNKYETEINITK---TTIKEISMQKEDDSKNLRNQLDRL 1242
               E EL +       E    R + E E    +      +E  + +E+  K  R +L+R 
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ 1169

Query: 1243 SRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE-----LKQ 1297
             RE  +L+ E     + +L+  +++RR E     ++    +  ++KQ    E     LK 
Sbjct: 1170 YREEEELQQE----EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225

Query: 1298 VMQQRSEDNARHKQ------------SLEEAAKTIQDKNKEIERLKAEFQE----EAKRR 1341
              +   E+  R  +             LE++    +   ++++ L  E QE    + +RR
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRE 1401
            W+  +     R+  +EE +  + Q E +    K+   +  +++E +    R + D   RE
Sbjct: 1286 WQQRD-----RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE 1340

Query: 1402 NRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE 1461
               L +E  R +  L +   + +  EE+++ Q+  G +  + +Q+L  + R+   ++ E+
Sbjct: 1341 EEQLLQE--REEQPLRRQERDRKFREEELRHQEQ-GRKFLEEEQRLRRQERERKFLKEEQ 1397

Query: 1462 SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENA--RLQRVQYDLQKANS 1519
             +R ++         QD++++    +Q + ++  DRK  E+E    R +R +  L++   
Sbjct: 1398 QLRCQEREQQLR---QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454

Query: 1520 SATETINKLKVQEQ--------ELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQ 1571
               E   K + +EQ        +L R   D + + +E+ ++ Q+  R     +E +L+ Q
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR---KFREQELRSQ 1511

Query: 1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631
            + E +    ++       +RK L+EE + +RR  + Q  +     +  E+  + ++R E 
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQ-LRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570

Query: 1632 DL-RQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIE 1690
             L RQ+RD       +K R QE+ R+   + + LRRQ  Q+Q       LR E  +K  E
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQ-------LRQERDRKFRE 1623

Query: 1691 DKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATIL 1750
            D+       + ++ R Q       +E   L  + R  +L +D  R+ R E    +     
Sbjct: 1624 DEQLLQEREEQQLHR-QERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682

Query: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ 1810
            +LR Q +    R  E Q  +   +RER+ L++E ++ ++Q LE   R +E   Q T+  Q
Sbjct: 1683 QLRRQERDRKFREEEQQ--LRRQERERKFLQEE-QQLRRQELERKFREEEQLRQETEQEQ 1739

Query: 1811 ERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLN----- 1865
             R     + K+LE+++ R +R E +L R +   +     + R E E+QQ+++  +     
Sbjct: 1740 LRRQERYR-KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFR 1798

Query: 1866 -----------------------QWKTQYSRKEEAIRKIESEREKSER-------EKNSL 1895
                                   +W+ +  + EE  +++  ER++  R       ++ S 
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSR 1858

Query: 1896 RSEIERLQAEI-KRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1954
            R E E  Q E  KR +ER R+  E+  R  + Q E +R R   EI     + +G   E  
Sbjct: 1859 REEQELWQEEEQKRRQERERKLREEHIR--RQQKEEQRHRQVGEIKSQEGKGHGRLLEPG 1916

Query: 1955 T 1955
            T
Sbjct: 1917 T 1917



 Score =  145 bits (367), Expect = 4e-34
 Identities = 167/751 (22%), Positives = 355/751 (47%), Gaps = 75/751 (9%)

Query: 1239 LDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQV 1298
            LD   R   D K+ +++      Q  +QRR    +   ++  G    QK+Q  E EL + 
Sbjct: 95   LDEEKRARCDGKESLLQ---DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE- 150

Query: 1299 MQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDE- 1357
                 E+ +  ++ LE+  +  Q +++E+ R + E+QE  +RR E E +L   + +  E 
Sbjct: 151  ----GEEQSEKQERLEQRDR--QRRDEELWRQRQEWQEREERRAE-EEQLQSCKGHETEE 203

Query: 1358 ----------EIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSE 1407
                      E++ L+ +   E    +        Q+EE+   +R +   L +E   L E
Sbjct: 204  FPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKE-WRKRETVLRKEEEKLQE 262

Query: 1408 EIKRLKNTLTQTTENLRRVE-EDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYK 1466
            E  + +  L +  E LR++E +++++++       Q ++Q +  LR+  Q+R ++    +
Sbjct: 263  EEPQRQRELQEEEEQLRKLERQELRRER-------QEEEQQQQRLRREQQLRRKQEEERR 315

Query: 1467 QSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETIN 1526
            +  ++  +  + + ++ ER +Q + +E  +R+       +L+R Q + ++      + + 
Sbjct: 316  EQQEERREQQERREQQEERREQQLRREQEERR-----EQQLRREQEEERR-----EQQLR 365

Query: 1527 KLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASE 1586
            + + +E+   +LR + +   +++  ++Q + R Q   +E QL++   E++L R ++   E
Sbjct: 366  REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR---EQQLRREQQLRRE 422

Query: 1587 DSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLRE 1646
               +R++ EE  E       EQ  +   L ++ E+     KR E+  R +++     L+ 
Sbjct: 423  QQLRREQEEERHE----QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478

Query: 1647 KQRTQEELRRLSSEVEALR-------RQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNES 1699
             Q  +   R L  E E  R       +QL +EQE  ++  L+ +  ++ ++ + RS  + 
Sbjct: 479  DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538

Query: 1700 KIE-IERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQI 1758
            + E  ER + L +   ++ L  E   + L+ E ++ R    + + ++    L+   + ++
Sbjct: 539  RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598

Query: 1759 SNN-RTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQE--RESL 1815
                +  E++ L  + +RE+   R+E E+ ++Q L  S   +E + Q  +  Q+  RE  
Sbjct: 599  EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658

Query: 1816 LVKIKVLEQDKARLQRLEDELNRAKSTLE-----AETRVKQRLECEKQQIQNDLNQWKTQ 1870
            L + +  E+ + RL+R  +E  R +   E     A  R+K R+   + Q++++ +  +++
Sbjct: 659  LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718

Query: 1871 -YS--RKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQ 1927
             YS  RK+E  R+ + + EK  R ++ L+ + E  +A  ++ EE  RR   D T + Q++
Sbjct: 719  VYSRPRKQEGQRRRQEQEEKRRRRESELQWQ-EEERAHRQQQEEEQRR---DFTWQWQAE 774

Query: 1928 LETERSRYQREIDKLRQRPYGSHRETQTECE 1958
             ++ER R +       + P    RE Q   E
Sbjct: 775  EKSERGRQRLS----ARPPLREQRERQLRAE 801



 Score =  137 bits (345), Expect = 2e-31
 Identities = 192/882 (21%), Positives = 385/882 (43%), Gaps = 106/882 (12%)

Query: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073
            YR   E+ +  E L  +  +    +E  R  R+       + + L +  +K + +  + +
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ--ELE 1137

Query: 1074 AKLASLEELKRQAEL-----DGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSV 1128
             +    EE++++ E        K  +Q L++ Y + +EL ++  +L  E ++++R+ +  
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197

Query: 1129 EDRFDQQKNDYDQLQKAR-QCEKENLGWQ-KLESEKAIKE-------------KEYEIER 1173
            + R +++     + Q+ R + ++ +L WQ + E E A+++             ++ E  +
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ 1257

Query: 1174 LRV---------LLQEEGTRKREYENELAKVRNHY--NEEMSNLRNKYETEINITKTTIK 1222
            LR          LL E+  R RE E    + R+ +   EE      + E +    K+  +
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE 1317

Query: 1223 EISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS 1282
            +  +++E + K  R + DR  RE   L  E     +  L+  E+ R+  E  L+ +  G 
Sbjct: 1318 KQLLREEREEKRRRQETDRKFREEEQLLQE---REEQPLRRQERDRKFREEELRHQEQGR 1374

Query: 1283 EIMQKKQHLEIELKQVMQQRSEDNARHKQSL---EEAAKTIQDKNKEIERLKAEFQEEAK 1339
            + ++++Q L        Q+R     + +Q L   E   +  QD++++    + +   + +
Sbjct: 1375 KFLEEEQRLR------RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428

Query: 1340 RRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLT 1399
             R   E E    R   + + +  + Q   E +       QL  ++EE       Q+    
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ------QLHRQE 1482

Query: 1400 RENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRT 1459
            R+ + L EE            + LRR E D + ++         ++ LE E +   Q R 
Sbjct: 1483 RDRKFLEEE------------QQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530

Query: 1460 EESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANS 1519
             + ++ +Q L           +  ER +Q   ++  DRK  E+E  R +R +  L +   
Sbjct: 1531 RKFLQEEQQL-----------RRQERGQQR--RQDRDRKFREEEQLRQEREEQQLSRQER 1577

Query: 1520 SATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLK---ELQLQKQKVEEE 1576
                 + + KV+ QE  R  ++ E+  Q R  + Q   R +   K   + QL +++ E++
Sbjct: 1578 DRKFRLEEQKVRRQEQERKFMEDEQ--QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635

Query: 1577 LNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLR-Q 1635
            L+R +R        RK LEEE + +RR  +EQ ++     +  E+  ++++  E  LR Q
Sbjct: 1636 LHRQERD-------RKFLEEEPQ-LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687

Query: 1636 QRD--------VLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL-RNEHFQ 1686
            +RD         L    RE++  QEE +    E+E   R+  Q ++  +Q  L R E ++
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747

Query: 1687 KAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN 1746
            K +E++       + ++ R +   +   +E L  E E + LR +  D R+ R E    + 
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD-RKFREEEQLRQE 1806

Query: 1747 ATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCT 1806
                +LR Q +    R  E Q     L+ + + LRQE ++ Q +A E     ++S+ +  
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQ---LQLEEQEQRLRQERDR-QYRAEEQFATQEKSRREEQ 1862

Query: 1807 QVVQERES--LLVKIKVLEQDKARLQRLEDELNRAKSTLEAE 1846
            ++ QE E      + + L ++  R Q+ E++ +R    ++++
Sbjct: 1863 ELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904



 Score =  132 bits (331), Expect = 6e-30
 Identities = 210/966 (21%), Positives = 429/966 (44%), Gaps = 88/966 (9%)

Query: 1038 EEELRLARDANSENCNKN---KFLDQNL--QKYQAECSQFKAKLASLEELKRQAELDGKS 1092
            E++LR  ++   E   K    K L+Q    Q+ + E  + + +L   EE +RQ  L  + 
Sbjct: 535  EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594

Query: 1093 AK---QNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCE 1149
             +   Q L +   +  E  E+  +     E E+ RR+ +    +Q++    QL++ +Q  
Sbjct: 595  EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654

Query: 1150 KENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
            +E    Q+L+ E+   E+E   +RL+   +EE   +   E E  + R      +   + +
Sbjct: 655  RE----QRLKREE---EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQ 707

Query: 1210 YETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRR- 1268
             E+E +  ++ +     ++E   +    +  R  RE+     E  R +    Q  EQRR 
Sbjct: 708  LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ-QQEEEQRRD 766

Query: 1269 -----RAEENALQQKACGSEIMQKKQHLEIELK-QVMQQRSEDNARHKQSLEEAAKTIQD 1322
                 +AEE + + +   S     ++  E +L+ +  QQR +     ++  E+  +  ++
Sbjct: 767  FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826

Query: 1323 KNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTM 1382
            + KE++ L+   +EE  +R E   +L +  +   E+    ++Q +      +  + +   
Sbjct: 827  REKELQFLE---EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883

Query: 1383 QKEEDTSGYRAQIDNLTRENRSLSEE---IKRLKNTLTQTTENLRRVEEDIQQQKATGSE 1439
            ++        A  + L +E + L EE   ++R +    +  E  R+  E+ Q Q+    E
Sbjct: 884  RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ---EE 940

Query: 1440 VSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKE---TND 1496
                +++ E   RQ  + +  +  + +Q  +       +K +  ER K+  ++E     +
Sbjct: 941  EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000

Query: 1497 RKCLEDENARLQRVQYDLQ-KANSSATETINKLKVQEQELTRLR------IDYERVSQE- 1548
             + L +E  + +R +++ Q +      +   +L  +E+E  RL+       + E + QE 
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060

Query: 1549 --------RTVKDQDITRFQNSLKELQL-QKQKVEEELNRLKRTASEDSCK-RKKLEEEL 1598
                     T + Q++ R     +ELQ  ++Q + EE  + +R   E  C+  ++L++E 
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120

Query: 1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQ-----RDVLDGHLREKQRTQEE 1653
            E + R  +E+  +   L +Q  +   V++  E  LR++     R  L+   RE++  Q+E
Sbjct: 1121 EQLLREEREKR-RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179

Query: 1654 LRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENL 1713
              +L  E +  RRQ  + Q   ++   R +  Q+  ++  RS  + + E E+  ++ +N 
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN- 1238

Query: 1714 TKEHLMLEEELRNLRLEYDDLRRGRSEAD------SDKNATILELRSQLQISNNRTLELQ 1767
             K +    E  +  +LE   LR  +S+ D        +     + R + Q  +    E +
Sbjct: 1239 -KVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE 1297

Query: 1768 GLINDLQRE---RENLRQEIEKFQKQALEASNRIQESKNQC---TQVVQERESLLVKIKV 1821
             L  + Q+E   R+   QE ++  ++  E   R QE+  +     Q++QERE   ++   
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR--- 1354

Query: 1822 LEQDKARLQRLEDEL---NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878
              Q++ R  R E+EL    + +  LE E R++ R E E++ ++ +      Q  R +E  
Sbjct: 1355 -RQERDRKFR-EEELRHQEQGRKFLEEEQRLR-RQERERKFLKEE------QQLRCQERE 1405

Query: 1879 RKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQRE 1938
            +++  +R++  RE+    S  ER +   +  ++  R++ E    E + QL  ER R  RE
Sbjct: 1406 QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE 1465

Query: 1939 IDKLRQ 1944
             ++L Q
Sbjct: 1466 EEQLLQ 1471



 Score = 92.0 bits (227), Expect = 7e-18
 Identities = 113/486 (23%), Positives = 220/486 (45%), Gaps = 53/486 (10%)

Query: 1481 KEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRI 1540
            K ++ + +L+D ++N R    +    + +V      A   AT           E  R R 
Sbjct: 52   KTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGL--------DEEKRARC 103

Query: 1541 DYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL-E 1599
            D +    +   +++D  RF+   ++L       EEE  + +R       KR++ E EL E
Sbjct: 104  DGKESLLQDRRQEEDQRRFEPRDRQL-------EEEPGQRRRQ------KRQEQERELAE 150

Query: 1600 GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLD-------GHLREKQRTQE 1652
            G  +S K++  ++    +Q     + ++R E   R++R   +       GH  E+   +E
Sbjct: 151  GEEQSEKQE--RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208

Query: 1653 ELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTEN 1712
            +LRR   E+  LRR+  +E++  +Q   R +   +  E+K     E+ +  E  +   E 
Sbjct: 209  QLRR--RELLELRRKGREEKQ--QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264

Query: 1713 LTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLIND 1772
              ++  + EEE +  +LE  +LRR R E +  +      LR + Q+   +  E +    +
Sbjct: 265  PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ----RLRREQQLRRKQEEERREQQEE 320

Query: 1773 LQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRL 1832
             + ++E   Q+ E+ ++Q        +E + +  Q  + RE  L + +  E+ + +L+R 
Sbjct: 321  RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR- 379

Query: 1833 EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK 1892
            E +L R     E + R +Q+L  E QQ++ +    + Q  R+E+ +R+ +  R + E E+
Sbjct: 380  EQQLRR-----EQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433

Query: 1893 NSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRE 1952
            +  + E ER        E+R +R+ E+     + + ETER   +R   +L++      RE
Sbjct: 434  HEQKHEQERR-------EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486

Query: 1953 TQTECE 1958
               + E
Sbjct: 487  RWLKLE 492



 Score = 39.3 bits (90), Expect = 0.057
 Identities = 57/270 (21%), Positives = 115/270 (42%), Gaps = 31/270 (11%)

Query: 236  DKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCE----E 291
            ++++ + REK    + E +Y    +   E    LR+ +   +   RE  +  D +    E
Sbjct: 911  EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970

Query: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIE--- 348
            E+LL +  +K             R  + E K +E  +L+QE +QL+  +     + E   
Sbjct: 971  EQLLGEEPEKR------------RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWER 1018

Query: 349  --AYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
                 D LQ +   +L+  +     L+E    ++  EE Q  E  L G +   R++   +
Sbjct: 1019 QYRKKDELQQEEEQLLREER-EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELE 1077

Query: 407  ----KNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPII 462
                K   LQ   EQ+   E E+ +  E +RQ +      ++  QL     + R  + + 
Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE 1137

Query: 463  LRALCDYKQDQKIVHKGDECILKDNNERSK 492
             +    Y+++++ V + +E +L++  E+ +
Sbjct: 1138 RQ----YREEEE-VQQEEEQLLREEPEKRR 1162


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  184 bits (466), Expect = 1e-45
 Identities = 242/1166 (20%), Positives = 511/1166 (43%), Gaps = 169/1166 (14%)

Query: 876  FRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHS 935
            +RL+   K + Q+    +  QA    L   K RQ   E+            L E +  HS
Sbjct: 835  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENE-----------LKELEQKHS 883

Query: 936  EISGKRDK-SEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQ 994
            +++ +++   E++Q   EL A + ++  ++LA+    LE +L+    R   +   G  LQ
Sbjct: 884  QLTEEKNLLQEQLQAETELYAEA-EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942

Query: 995  EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNT----KIEVLEEELRLARDANSE 1050
                  A   ++  +  D    L E   + + L+L+      KI+ LE+E+ +  D N++
Sbjct: 943  ------AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN-- 1108
               + K L++ +       ++ + K  +L +LK + E                I EL   
Sbjct: 997  LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE--------------SMISELEVR 1042

Query: 1109 -EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD------QLQKARQCEKENLGWQKLESE 1161
             +K  +   E+E  KR+ +     F +Q  D        ++Q A++ E+      +L+ E
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102

Query: 1162 KAIKEKEYEIERLRVL------LQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEIN 1215
              I +K   ++++R L      LQE+   +R   N+  K +    EE+  L+ + E  ++
Sbjct: 1103 --IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSREN----RDLKDEIVRLNDSILQATEQRRRAE 1271
             T T  +E+  ++E +   L+  LD  +R +    ++++ +  +  + + +  EQ +RA+
Sbjct: 1161 STATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219

Query: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 1331
             N  + K     + ++   L  EL+ V+ Q  ++    K+ LE   + +Q K  + ER +
Sbjct: 1220 ANLDKNK---QTLEKENADLAGELR-VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275

Query: 1332 AEFQEEAKRRWEYENELSKVRNNYDE----------EIISLKNQFE-TEINITKTTIHQL 1380
            AE  ++  +    +NE+  V    +E          ++ SL +Q + T+  + + T  +L
Sbjct: 1276 AELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332

Query: 1381 TM-----QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA 1435
             +     Q EE+ +  + Q+D      ++L   I  L   L+ + + L       Q   +
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL-------QDFAS 1385

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRY----------KQSLDDAAKTIQDKNKEIER 1485
            T   + + K++ + E+  +TQ   E++  Y          +Q LDD    + ++ + +  
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445

Query: 1486 LK-------QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR- 1537
            L+       QL+ +E N      DE  R +    + +    S    + +    ++EL R 
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 1538 ---LRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT--ASEDSCKRK 1592
               L+ + E +   +    +++   + S + L+ Q ++++ +L  L+    A+ED+  R 
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 1593 KL--------------------EEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632
            ++                    EE+   ++R L E   ++ +  +Q   A+  KK+ E D
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625

Query: 1633 LRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED- 1691
            L+      D  ++ ++   ++LR+L ++++  +R+L   + S      R+E F  A E+ 
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENE 1679

Query: 1692 -KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN---A 1747
             K++SL    ++++   +  E   K+  + +EEL     E      GR+    +K    A
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE---ELASSLSGRNALQDEKRRLEA 1736

Query: 1748 TILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQ 1807
             I +L  +L+        +   +    ++ E L  E+         A+ R    KN+  +
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL---------ATERSTAQKNESAR 1787

Query: 1808 VVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE-TRVKQRLECEKQQIQNDLNQ 1866
               ER++  ++ K+ E + A   + +  +    + LEA+  ++++++E E ++ Q     
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTI----AALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K +  + +E + ++E ER+ +E+ K     + E+  A +K++    +R+LE++  E+Q 
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYK----EQAEKGNARVKQL----KRQLEEAEEESQ- 1894

Query: 1927 QLETERSRYQREIDKLRQRPYGSHRE 1952
            ++   R + QRE+D+  +      RE
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGRE 1920



 Score =  182 bits (463), Expect = 3e-45
 Identities = 220/1048 (20%), Positives = 456/1048 (43%), Gaps = 127/1048 (12%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  +++  E+EL+  ++   +  N+ K L+Q
Sbjct: 824  AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 880

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
               +   E +  + +L +  EL  +AE       +   +   + +EL E +  +   +E+
Sbjct: 881  KHSQLTEEKNLLQEQLQAETELYAEAE-------EMRVRLAAKKQELEEILHEMEARLEE 933

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
            E+ R + ++   +++K     L    Q E+E    QKL+ EK   E + +     +L+ +
Sbjct: 934  EEDRGQQLQA--ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991

Query: 1181 EGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIK--------EISMQKEDDS 1232
            +   K   E +L + R   ++  +NL  + E   N+TK   K        E+ ++KE+ S
Sbjct: 992  DQNNKLSKERKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049

Query: 1233 KNLRNQLDR-LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKA-CGSEIMQKKQH 1290
            +    +L R L  +  D  ++I  L   I +   Q  + EE      A    EI QK   
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109

Query: 1291 LEI--ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE-------EAKRR 1341
            L+   EL+  +    ED    + +  +A K  +D  +E+E LK E ++       + + R
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDN---- 1397
             + E E++ ++   DEE  S + Q +         + +LT Q E+     +A +D     
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQT 1228

Query: 1398 LTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS-------EVSQRKQQLEVE 1450
            L +EN  L+ E++ L     +     +++E  +Q+ ++  S       E++ +  +L+ E
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288

Query: 1451 LRQVTQMRTE----------ESVRYKQSLDDAAKTIQDKNKE----IERLKQLIDKETND 1496
            +  VT M  E          +       L D  + +Q++ ++      +L+QL ++  + 
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348

Query: 1497 RKCLEDENARLQRVQYDLQKANSSATETINKL--------------KVQEQELTRLRIDY 1542
            +  L++E    Q ++  +   N   +++  KL              K  ++E+  L   Y
Sbjct: 1349 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408

Query: 1543 ERVSQERTVKDQDITRFQNSLKELQL----QKQKV---EEELNRLKRTASEDSCKRKKLE 1595
            E  +      ++   R Q  L +L +    Q+Q V   E++  +  +  +E+     K  
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468

Query: 1596 EELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE----------DDLRQQRDVLDGHLR 1645
            +E +      +E+  K  +L + LE+A   K+  E          +DL   +D +  ++ 
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528

Query: 1646 EKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI---------------E 1690
            E ++++  L     E++    +L  E ++ + A LR E   +A+               E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 1691 DKSRSLN------ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
            +K R L       E+++E ER Q       K+ L  E +L++L L+ D   +GR EA   
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKL--EGDLKDLELQADSAIKGREEAIKQ 1646

Query: 1745 KN---ATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQES 1801
                 A + + + +L+ +     E+     + +++ ++L  ++ + Q+    A    +++
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706

Query: 1802 KNQCTQVVQERESLLVKIKVLEQDKARLQ----RLEDELNRAKSTLEAETRVKQRLECEK 1857
              +  ++ +E  S L     L+ +K RL+    +LE+EL   +  +EA +   ++   + 
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q+ N+L       + +    +K ES R++ ER+   LRS++  ++  +K   +     L
Sbjct: 1767 EQLSNEL-------ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            E    + + Q+E E    Q     L+Q+
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQK 1847



 Score =  174 bits (440), Expect = 1e-42
 Identities = 204/987 (20%), Positives = 434/987 (43%), Gaps = 129/987 (13%)

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
            +  +QA C  + A+ A     KRQ +L      Q    C   +K  N +  RL  +++  
Sbjct: 790  IMAFQAMCRGYLARKAFA---KRQQQLTAMKVIQR--NCAAYLKLRNWQWWRLFTKVKPL 844

Query: 1122 KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE-KAIKEKEYEIERLRVLLQE 1180
             +  +  E+   Q K D  Q  K RQ        QK E+E K +++K  ++   + LLQE
Sbjct: 845  LQVTRQEEEM--QAKEDELQKTKERQ--------QKAENELKELEQKHSQLTEEKNLLQE 894

Query: 1181 EGTRKREYENELAKVRNHY---NEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRN 1237
            +   + E   E  ++R       +E+  + ++ E  +            ++ED  + L+ 
Sbjct: 895  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-----------EEEDRGQQLQA 943

Query: 1238 QLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSE----IMQKKQHLEI 1293
            +  +++++  DL++++        +A  Q+ + E+   + K    E    +M  + +   
Sbjct: 944  ERKKMAQQMLDLEEQLEEE-----EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 1294 ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353
            + ++++++R  D   +    EE AK +     + E + +E +   K+  +   EL K++ 
Sbjct: 999  KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058

Query: 1354 NYDEEIISLKNQFETEINITKTTIHQLTMQ---KEEDTSGYRAQIDNLTRENRSLSEEIK 1410
              + +     + F  +I   +  I +L MQ   KEE+     A++D+   +  +  ++I+
Sbjct: 1059 KLEGDA----SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114

Query: 1411 RLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD 1470
             L+  ++        ++ED+  ++A  ++  ++K+ L  EL     ++TE     + +LD
Sbjct: 1115 ELEGHISD-------LQEDLDSERAARNKAEKQKRDLGEELEA---LKTE----LEDTLD 1160

Query: 1471 DAAKTIQ---DKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINK 1527
              A   +    + +E+  LK+ +D+ET   +      A++Q ++    +A    TE + +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHE------AQVQEMRQKHAQAVEELTEQLEQ 1214

Query: 1528 LKVQEQELTRLRIDYER----VSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT 1583
             K  +  L + +   E+    ++ E  V  Q     ++  K+L+ Q Q+++ + +  +R 
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274

Query: 1584 ASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGH 1643
             +E + K  KL+ E+E +   L E   K   L + +   S         L+  +++L   
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-------SQLQDTQELLQEE 1327

Query: 1644 LREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI 1703
             R+K     +LR+L  E  +L+ QL +E E+        ++ ++ I   +  L++SK ++
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-------KQNLERHISTLNIQLSDSKKKL 1380

Query: 1704 ERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763
            +   S  E L +     ++E+ NL  +Y++      + +  KN                 
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN----------------- 1423

Query: 1764 LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE 1823
              LQ  ++DL  + +N RQ +   +K+  +    + E KN  ++   ER+    + +  E
Sbjct: 1424 -RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQ------------------RLECEKQQIQNDLN 1865
                 L R  +E   AK  LE   ++ +                   LE  K+ ++  + 
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 1866 QWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER-LQAEIKRIEERCRRKLEDSTRET 1924
            + KTQ    E+ ++  E  + + E    +L+ + ER LQA  ++ EE+ RR+L+    E 
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK-RRQLQRQLHEY 1601

Query: 1925 QSQLETERSRYQREI-DKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYEC 1983
            +++LE ER   QR +    +++  G  ++ + + +  +   +     LRK    M+ ++ 
Sbjct: 1602 ETELEDERK--QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 1984 QLID-KTTLDKLLKGKKSVEEVASEIQ 2009
            +L D + + D++    K  E+ A  ++
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLE 1686



 Score =  172 bits (437), Expect = 3e-42
 Identities = 244/1188 (20%), Positives = 500/1188 (42%), Gaps = 154/1188 (12%)

Query: 770  VRALLQAILQTEDM-LKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            V+ LLQ   Q E+M  K  E + T+E        K E     L++  + L  +K+LL   
Sbjct: 841  VKPLLQVTRQEEEMQAKEDELQKTKERQ-----QKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 829  ---KTELQ-KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRID---KQIDFRLWDL 881
               +TEL  +A+++  + + +    +  L +   ++ +  DR Q++    K++  ++ DL
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 882  EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVM----RFLNEQ-KNLHSE 936
            E+Q+++    R   Q   K   +AK ++   E +   D N  +    + L E+  +L + 
Sbjct: 956  EEQLEEEEAARQKLQLE-KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 937  ISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEA 996
            ++ + +K++ + K+     + I + E++L       + L  +  K   ++  +    ++ 
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDASDFHEQI 1071

Query: 997  ADVHARYIELLTRSGDYYRFLSEMLKSLED-LKLKNT---KIEVLEEELR-LARDANSEN 1051
            AD+ A+  EL  +       L   L  L+D +  KN    KI  LE  +  L  D +SE 
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 1052 CNKNKF------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDK----CY 1101
              +NK       L + L+  + E        A+ +EL+ + E +    K+ LD+      
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191

Query: 1102 GQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
             Q++E+ +K  +   E+ ++  + K  +   D+ K   ++       E   LG  K E E
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251

Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI 1221
               K+ E +++ L+    +    + E  +++ K++N   E ++ + N+ E +       +
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKDV 1310

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
              +S Q +D  + L+ +    +R+  ++  ++ +L +            E N+LQ +   
Sbjct: 1311 ASLSSQLQDTQELLQEE----TRQKLNVSTKLRQLEE------------ERNSLQDQL-- 1352

Query: 1282 SEIMQKKQHLEIELKQVMQQRSE------DNARHKQSLEEAAKTIQDKNKEIERLKAEFQ 1335
             E M+ KQ+LE  +  +  Q S+      D A   ++LEE  K  Q   KEIE L  +++
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ---KEIENLTQQYE 1409

Query: 1336 EEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT--IHQLTMQKEEDTSGY-- 1391
            E+A    + E   ++++   D+ ++ L NQ +   N+ K      QL  +++  +S Y  
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 1392 ---RAQIDNLTRENRSLS-----EEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQR 1443
               RA+ +   +E ++LS     EE    K  L +T + L+   ED+   K    +V + 
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK---DDVGKN 1526

Query: 1444 KQQLEVELRQV-TQMRTEESVRYKQSLDDAAKTIQDKNKEIE----RLKQLIDKETNDRK 1498
              +LE   R + TQM  EE     + L+D  +  +D    +E     LK   +++   R 
Sbjct: 1527 VHELEKSKRALETQM--EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584

Query: 1499 CLEDENAR-----LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
               +E  R     L   + +L+             K  E +L  L +  +   + R    
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKIT 1613
            + + + Q  +K+ Q + +      + +  TA E+  K K LE +L               
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL--------------M 1690

Query: 1614 NLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673
             L + L  A   +K+++ +  +  + L   L  +   Q+E RRL + +  L  +L +EQ 
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750

Query: 1674 SVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDD 1733
            +++    R     +  E  S  L   +   ++ +S  + L +++  L  +L  +      
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM------ 1804

Query: 1734 LRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALE 1793
                       + A   + +S +     +  +L+  +    RE++   + +++  K+  E
Sbjct: 1805 -----------EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853

Query: 1794 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1853
               ++++ +    Q  ++ E    ++K L   K +L+  E+E               QR+
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQL---KRQLEEAEEE--------------SQRI 1896

Query: 1854 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER 1901
               ++++Q +L++                   E   RE N+L+S++ R
Sbjct: 1897 NANRRKLQRELDE--------------ATESNEAMGREVNALKSKLRR 1930



 Score =  134 bits (337), Expect = 1e-30
 Identities = 191/1017 (18%), Positives = 432/1017 (42%), Gaps = 135/1017 (13%)

Query: 743  QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
            QN      +KL  E I+ +T          + L +   + E M+   E RL +EE    +
Sbjct: 993  QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1052

Query: 801  LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
            L+K++      +K++ D +     +A ++ ++    ++  Q +++       L +  +++
Sbjct: 1053 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1103

Query: 861  TQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQD---SLESMKF 917
             Q  +  ++I ++++  + DL++ +   R  R+  +         K+++D    LE++K 
Sbjct: 1104 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE---------KQKRDLGEELEALKT 1153

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLN 977
               +T+     +Q     E+  KR+  +EV  + +      + +E Q+            
Sbjct: 1154 ELEDTLDSTATQQ-----ELRAKRE--QEVTVLKKALDEETRSHEAQV------------ 1194

Query: 978  IPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYY-RFLSEMLKSLEDLKLKNTKIEV 1036
                            QE    HA+ +E LT   + + R  + + K+ + L+ +N     
Sbjct: 1195 ----------------QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD--- 1235

Query: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
            L  ELR+   A  E  +K K L+  +Q+ Q++CS  +   A L +   + + + +S    
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1295

Query: 1097 LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQ 1156
            L++  G+  +L + +  L+ +++D +   +      ++ +   +   K RQ E+E    Q
Sbjct: 1296 LNEAEGKAIKLAKDVASLSSQLQDTQELLQ------EETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 1157 -KLESEKAIKEK-EYEIERLRVLLQEEGTRKREYENE---LAKVRNHYNEEMSNLRNKYE 1211
             +L+ E   K+  E  I  L + L +   + +++ +    L + +  + +E+ NL  +YE
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 1212 TE------INITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATE 1265
             +      +  TK  +++       D  N R  +  L ++ R     +    +   +  +
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 1266 QRRRAEENALQQKACG-------SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAK 1318
            +R RAE  A +++           E ++ K+ LE    ++++   ED    K   ++  K
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSK---DDVGK 1525

Query: 1319 TIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN---NYDEEIISLKNQFETEINITKT 1375
             + +  K    L+ + +E   +  E E+EL    +     +  + +LK QFE ++     
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585

Query: 1376 TIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKR-----LKNTLTQTTENLRRVEEDI 1430
               +   Q +     Y  ++++  R+ R+L+   K+     LK+   Q    ++  EE I
Sbjct: 1586 QNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 1431 QQQKATGSEVSQRKQQLEVELRQVTQM--RTEESVRYKQSLDDAAKTIQDKNKEIERLKQ 1488
            +Q +   +++   +++LE       ++    +E+ +  +SL+     +Q+     ER ++
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704

Query: 1489 LIDKETND-----------RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR 1537
              D E  +           R  L+DE  RL+     L++      E    ++     + +
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE---ELEEEQGNMEAMSDRVRK 1761

Query: 1538 LRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRL--------KRTASEDSC 1589
                 E++S E   +     + +++ ++L+ Q +++  +L+ +        K T +    
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821

Query: 1590 KRKKLEEELEGMRR-------SLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDG 1642
            K  +LEE++E   R       SLK++  K+  +  Q+E     +++  +  ++Q +  + 
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED----ERKMAEQYKEQAEKGNA 1877

Query: 1643 HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNES 1699
             +++ +R  EE    S  + A RR+L +E +   +++        A++ K R  NE+
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET 1934



 Score = 38.9 bits (89), Expect = 0.074
 Identities = 56/258 (21%), Positives = 103/258 (39%), Gaps = 38/258 (14%)

Query: 215  EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQN 274
            E+ I   R +   + D++ +L+  +A   E  A  +  E+    L+A       L QLQ 
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD------LMQLQE 1694

Query: 275  IIQATSREIMWINDCEEEELLYDWSDK--------------NTNIAQKQEAFSIRMSQLE 320
             + A  R      D E+EEL  + +                   IAQ +E        +E
Sbjct: 1695 DLAAAERARKQA-DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1753

Query: 321  VKEKELNKLKQESDQL---VLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAA 377
                 + K  Q+++QL   +  +   + K E+    L+ Q   +        +H  E A 
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHEMEGAV 1808

Query: 378  YFQFFEEAQSTEAYLKGLQDSI----RKKYPCDKNMPL--QHLLEQIKELEKEREKILEY 431
              +F     + EA +  L++ +    R+K    K++    + L E + ++E ER+   +Y
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868

Query: 432  KRQVQNLVNKSKKIVQLK 449
            K Q +     + ++ QLK
Sbjct: 1869 KEQAE---KGNARVKQLK 1883



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)

Query: 55   GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
            GY      ++ Q Q T  +++Q NC+  L +R     +   K    +Q+TR  E     +
Sbjct: 799  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 858

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
            +   +  ++ +  ++ ++E+ Q        +K LLQ Q Q    LY      RVR A+ K
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 917

Query: 168  GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
                   +      E    +  E     R Q+ + +       +  +E+ +         
Sbjct: 918  Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 228  IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
            +     QL+K+ A+ + K    +LE+E    +    ++ + L + + +++    ++   N
Sbjct: 969  L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1014

Query: 288  DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
              EEEE       K  N+ + +      +S+LEV+ K+  K +QE ++L    +  ASD 
Sbjct: 1015 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 347  IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
             E   D LQ Q +            LK      Q  ++ +  +A L  L D I +K    
Sbjct: 1068 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1106

Query: 407  KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
                  + L++I+ELE    + ++ L+ +R  +N   K K+
Sbjct: 1107 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  184 bits (466), Expect = 1e-45
 Identities = 242/1166 (20%), Positives = 511/1166 (43%), Gaps = 169/1166 (14%)

Query: 876  FRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHS 935
            +RL+   K + Q+    +  QA    L   K RQ   E+            L E +  HS
Sbjct: 842  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENE-----------LKELEQKHS 890

Query: 936  EISGKRDK-SEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQ 994
            +++ +++   E++Q   EL A + ++  ++LA+    LE +L+    R   +   G  LQ
Sbjct: 891  QLTEEKNLLQEQLQAETELYAEA-EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949

Query: 995  EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNT----KIEVLEEELRLARDANSE 1050
                  A   ++  +  D    L E   + + L+L+      KI+ LE+E+ +  D N++
Sbjct: 950  ------AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN-- 1108
               + K L++ +       ++ + K  +L +LK + E                I EL   
Sbjct: 1004 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE--------------SMISELEVR 1049

Query: 1109 -EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD------QLQKARQCEKENLGWQKLESE 1161
             +K  +   E+E  KR+ +     F +Q  D        ++Q A++ E+      +L+ E
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109

Query: 1162 KAIKEKEYEIERLRVL------LQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEIN 1215
              I +K   ++++R L      LQE+   +R   N+  K +    EE+  L+ + E  ++
Sbjct: 1110 --IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSREN----RDLKDEIVRLNDSILQATEQRRRAE 1271
             T T  +E+  ++E +   L+  LD  +R +    ++++ +  +  + + +  EQ +RA+
Sbjct: 1168 STATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226

Query: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 1331
             N  + K     + ++   L  EL+ V+ Q  ++    K+ LE   + +Q K  + ER +
Sbjct: 1227 ANLDKNK---QTLEKENADLAGELR-VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282

Query: 1332 AEFQEEAKRRWEYENELSKVRNNYDE----------EIISLKNQFE-TEINITKTTIHQL 1380
            AE  ++  +    +NE+  V    +E          ++ SL +Q + T+  + + T  +L
Sbjct: 1283 AELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339

Query: 1381 TM-----QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA 1435
             +     Q EE+ +  + Q+D      ++L   I  L   L+ + + L       Q   +
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL-------QDFAS 1392

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRY----------KQSLDDAAKTIQDKNKEIER 1485
            T   + + K++ + E+  +TQ   E++  Y          +Q LDD    + ++ + +  
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452

Query: 1486 LK-------QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR- 1537
            L+       QL+ +E N      DE  R +    + +    S    + +    ++EL R 
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 1538 ---LRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT--ASEDSCKRK 1592
               L+ + E +   +    +++   + S + L+ Q ++++ +L  L+    A+ED+  R 
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 1593 KL--------------------EEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632
            ++                    EE+   ++R L E   ++ +  +Q   A+  KK+ E D
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632

Query: 1633 LRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED- 1691
            L+      D  ++ ++   ++LR+L ++++  +R+L   + S      R+E F  A E+ 
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENE 1686

Query: 1692 -KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN---A 1747
             K++SL    ++++   +  E   K+  + +EEL     E      GR+    +K    A
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE---ELASSLSGRNALQDEKRRLEA 1743

Query: 1748 TILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQ 1807
             I +L  +L+        +   +    ++ E L  E+         A+ R    KN+  +
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL---------ATERSTAQKNESAR 1794

Query: 1808 VVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE-TRVKQRLECEKQQIQNDLNQ 1866
               ER++  ++ K+ E + A   + +  +    + LEA+  ++++++E E ++ Q     
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTI----AALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K +  + +E + ++E ER+ +E+ K     + E+  A +K++    +R+LE++  E+Q 
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYK----EQAEKGNARVKQL----KRQLEEAEEESQ- 1901

Query: 1927 QLETERSRYQREIDKLRQRPYGSHRE 1952
            ++   R + QRE+D+  +      RE
Sbjct: 1902 RINANRRKLQRELDEATESNEAMGRE 1927



 Score =  182 bits (463), Expect = 3e-45
 Identities = 220/1048 (20%), Positives = 456/1048 (43%), Gaps = 127/1048 (12%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  +++  E+EL+  ++   +  N+ K L+Q
Sbjct: 831  AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 887

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
               +   E +  + +L +  EL  +AE       +   +   + +EL E +  +   +E+
Sbjct: 888  KHSQLTEEKNLLQEQLQAETELYAEAE-------EMRVRLAAKKQELEEILHEMEARLEE 940

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
            E+ R + ++   +++K     L    Q E+E    QKL+ EK   E + +     +L+ +
Sbjct: 941  EEDRGQQLQA--ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998

Query: 1181 EGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIK--------EISMQKEDDS 1232
            +   K   E +L + R   ++  +NL  + E   N+TK   K        E+ ++KE+ S
Sbjct: 999  DQNNKLSKERKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056

Query: 1233 KNLRNQLDR-LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKA-CGSEIMQKKQH 1290
            +    +L R L  +  D  ++I  L   I +   Q  + EE      A    EI QK   
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116

Query: 1291 LEI--ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE-------EAKRR 1341
            L+   EL+  +    ED    + +  +A K  +D  +E+E LK E ++       + + R
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDN---- 1397
             + E E++ ++   DEE  S + Q +         + +LT Q E+     +A +D     
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQT 1235

Query: 1398 LTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS-------EVSQRKQQLEVE 1450
            L +EN  L+ E++ L     +     +++E  +Q+ ++  S       E++ +  +L+ E
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295

Query: 1451 LRQVTQMRTE----------ESVRYKQSLDDAAKTIQDKNKE----IERLKQLIDKETND 1496
            +  VT M  E          +       L D  + +Q++ ++      +L+QL ++  + 
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355

Query: 1497 RKCLEDENARLQRVQYDLQKANSSATETINKL--------------KVQEQELTRLRIDY 1542
            +  L++E    Q ++  +   N   +++  KL              K  ++E+  L   Y
Sbjct: 1356 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415

Query: 1543 ERVSQERTVKDQDITRFQNSLKELQL----QKQKV---EEELNRLKRTASEDSCKRKKLE 1595
            E  +      ++   R Q  L +L +    Q+Q V   E++  +  +  +E+     K  
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475

Query: 1596 EELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE----------DDLRQQRDVLDGHLR 1645
            +E +      +E+  K  +L + LE+A   K+  E          +DL   +D +  ++ 
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535

Query: 1646 EKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI---------------E 1690
            E ++++  L     E++    +L  E ++ + A LR E   +A+               E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 1691 DKSRSLN------ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
            +K R L       E+++E ER Q       K+ L  E +L++L L+ D   +GR EA   
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKL--EGDLKDLELQADSAIKGREEAIKQ 1653

Query: 1745 KN---ATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQES 1801
                 A + + + +L+ +     E+     + +++ ++L  ++ + Q+    A    +++
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713

Query: 1802 KNQCTQVVQERESLLVKIKVLEQDKARLQ----RLEDELNRAKSTLEAETRVKQRLECEK 1857
              +  ++ +E  S L     L+ +K RL+    +LE+EL   +  +EA +   ++   + 
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q+ N+L       + +    +K ES R++ ER+   LRS++  ++  +K   +     L
Sbjct: 1774 EQLSNEL-------ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            E    + + Q+E E    Q     L+Q+
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQK 1854



 Score =  174 bits (440), Expect = 1e-42
 Identities = 204/987 (20%), Positives = 434/987 (43%), Gaps = 129/987 (13%)

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
            +  +QA C  + A+ A     KRQ +L      Q    C   +K  N +  RL  +++  
Sbjct: 797  IMAFQAMCRGYLARKAFA---KRQQQLTAMKVIQR--NCAAYLKLRNWQWWRLFTKVKPL 851

Query: 1122 KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE-KAIKEKEYEIERLRVLLQE 1180
             +  +  E+   Q K D  Q  K RQ        QK E+E K +++K  ++   + LLQE
Sbjct: 852  LQVTRQEEEM--QAKEDELQKTKERQ--------QKAENELKELEQKHSQLTEEKNLLQE 901

Query: 1181 EGTRKREYENELAKVRNHY---NEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRN 1237
            +   + E   E  ++R       +E+  + ++ E  +            ++ED  + L+ 
Sbjct: 902  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-----------EEEDRGQQLQA 950

Query: 1238 QLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSE----IMQKKQHLEI 1293
            +  +++++  DL++++        +A  Q+ + E+   + K    E    +M  + +   
Sbjct: 951  ERKKMAQQMLDLEEQLEEE-----EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 1294 ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353
            + ++++++R  D   +    EE AK +     + E + +E +   K+  +   EL K++ 
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065

Query: 1354 NYDEEIISLKNQFETEINITKTTIHQLTMQ---KEEDTSGYRAQIDNLTRENRSLSEEIK 1410
              + +     + F  +I   +  I +L MQ   KEE+     A++D+   +  +  ++I+
Sbjct: 1066 KLEGDA----SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121

Query: 1411 RLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD 1470
             L+  ++        ++ED+  ++A  ++  ++K+ L  EL     ++TE     + +LD
Sbjct: 1122 ELEGHISD-------LQEDLDSERAARNKAEKQKRDLGEELEA---LKTE----LEDTLD 1167

Query: 1471 DAAKTIQ---DKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINK 1527
              A   +    + +E+  LK+ +D+ET   +      A++Q ++    +A    TE + +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHE------AQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 1528 LKVQEQELTRLRIDYER----VSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT 1583
             K  +  L + +   E+    ++ E  V  Q     ++  K+L+ Q Q+++ + +  +R 
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281

Query: 1584 ASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGH 1643
             +E + K  KL+ E+E +   L E   K   L + +   S         L+  +++L   
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-------SQLQDTQELLQEE 1334

Query: 1644 LREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI 1703
             R+K     +LR+L  E  +L+ QL +E E+        ++ ++ I   +  L++SK ++
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-------KQNLERHISTLNIQLSDSKKKL 1387

Query: 1704 ERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763
            +   S  E L +     ++E+ NL  +Y++      + +  KN                 
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN----------------- 1430

Query: 1764 LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE 1823
              LQ  ++DL  + +N RQ +   +K+  +    + E KN  ++   ER+    + +  E
Sbjct: 1431 -RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQ------------------RLECEKQQIQNDLN 1865
                 L R  +E   AK  LE   ++ +                   LE  K+ ++  + 
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 1866 QWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER-LQAEIKRIEERCRRKLEDSTRET 1924
            + KTQ    E+ ++  E  + + E    +L+ + ER LQA  ++ EE+ RR+L+    E 
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK-RRQLQRQLHEY 1608

Query: 1925 QSQLETERSRYQREI-DKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYEC 1983
            +++LE ER   QR +    +++  G  ++ + + +  +   +     LRK    M+ ++ 
Sbjct: 1609 ETELEDERK--QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 1984 QLID-KTTLDKLLKGKKSVEEVASEIQ 2009
            +L D + + D++    K  E+ A  ++
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLE 1693



 Score =  172 bits (437), Expect = 3e-42
 Identities = 244/1188 (20%), Positives = 500/1188 (42%), Gaps = 154/1188 (12%)

Query: 770  VRALLQAILQTEDM-LKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            V+ LLQ   Q E+M  K  E + T+E        K E     L++  + L  +K+LL   
Sbjct: 848  VKPLLQVTRQEEEMQAKEDELQKTKERQ-----QKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 829  ---KTELQ-KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRID---KQIDFRLWDL 881
               +TEL  +A+++  + + +    +  L +   ++ +  DR Q++    K++  ++ DL
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 882  EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVM----RFLNEQ-KNLHSE 936
            E+Q+++    R   Q   K   +AK ++   E +   D N  +    + L E+  +L + 
Sbjct: 963  EEQLEEEEAARQKLQLE-KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 937  ISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEA 996
            ++ + +K++ + K+     + I + E++L       + L  +  K   ++  +    ++ 
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDASDFHEQI 1078

Query: 997  ADVHARYIELLTRSGDYYRFLSEMLKSLED-LKLKNT---KIEVLEEELR-LARDANSEN 1051
            AD+ A+  EL  +       L   L  L+D +  KN    KI  LE  +  L  D +SE 
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 1052 CNKNKF------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDK----CY 1101
              +NK       L + L+  + E        A+ +EL+ + E +    K+ LD+      
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198

Query: 1102 GQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
             Q++E+ +K  +   E+ ++  + K  +   D+ K   ++       E   LG  K E E
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258

Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI 1221
               K+ E +++ L+    +    + E  +++ K++N   E ++ + N+ E +       +
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKDV 1317

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
              +S Q +D  + L+ +    +R+  ++  ++ +L +            E N+LQ +   
Sbjct: 1318 ASLSSQLQDTQELLQEE----TRQKLNVSTKLRQLEE------------ERNSLQDQL-- 1359

Query: 1282 SEIMQKKQHLEIELKQVMQQRSE------DNARHKQSLEEAAKTIQDKNKEIERLKAEFQ 1335
             E M+ KQ+LE  +  +  Q S+      D A   ++LEE  K  Q   KEIE L  +++
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ---KEIENLTQQYE 1416

Query: 1336 EEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT--IHQLTMQKEEDTSGY-- 1391
            E+A    + E   ++++   D+ ++ L NQ +   N+ K      QL  +++  +S Y  
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 1392 ---RAQIDNLTRENRSLS-----EEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQR 1443
               RA+ +   +E ++LS     EE    K  L +T + L+   ED+   K    +V + 
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK---DDVGKN 1533

Query: 1444 KQQLEVELRQV-TQMRTEESVRYKQSLDDAAKTIQDKNKEIE----RLKQLIDKETNDRK 1498
              +LE   R + TQM  EE     + L+D  +  +D    +E     LK   +++   R 
Sbjct: 1534 VHELEKSKRALETQM--EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591

Query: 1499 CLEDENAR-----LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
               +E  R     L   + +L+             K  E +L  L +  +   + R    
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKIT 1613
            + + + Q  +K+ Q + +      + +  TA E+  K K LE +L               
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL--------------M 1697

Query: 1614 NLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673
             L + L  A   +K+++ +  +  + L   L  +   Q+E RRL + +  L  +L +EQ 
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757

Query: 1674 SVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDD 1733
            +++    R     +  E  S  L   +   ++ +S  + L +++  L  +L  +      
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEM------ 1811

Query: 1734 LRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALE 1793
                       + A   + +S +     +  +L+  +    RE++   + +++  K+  E
Sbjct: 1812 -----------EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860

Query: 1794 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1853
               ++++ +    Q  ++ E    ++K L   K +L+  E+E               QR+
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQL---KRQLEEAEEE--------------SQRI 1903

Query: 1854 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER 1901
               ++++Q +L++                   E   RE N+L+S++ R
Sbjct: 1904 NANRRKLQRELDE--------------ATESNEAMGREVNALKSKLRR 1937



 Score =  134 bits (337), Expect = 1e-30
 Identities = 191/1017 (18%), Positives = 432/1017 (42%), Gaps = 135/1017 (13%)

Query: 743  QNEVFGLFQKL--ENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLD 800
            QN      +KL  E I+ +T          + L +   + E M+   E RL +EE    +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQE 1059

Query: 801  LDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKV 860
            L+K++      +K++ D +     +A ++ ++    ++  Q +++       L +  +++
Sbjct: 1060 LEKLK------RKLEGDASDFHEQIADLQAQIA---ELKMQLAKKEEELQAALARLDDEI 1110

Query: 861  TQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQD---SLESMKF 917
             Q  +  ++I ++++  + DL++ +   R  R+  +         K+++D    LE++K 
Sbjct: 1111 AQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE---------KQKRDLGEELEALKT 1160

Query: 918  GDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLN 977
               +T+     +Q     E+  KR+  +EV  + +      + +E Q+            
Sbjct: 1161 ELEDTLDSTATQQ-----ELRAKRE--QEVTVLKKALDEETRSHEAQV------------ 1201

Query: 978  IPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYY-RFLSEMLKSLEDLKLKNTKIEV 1036
                            QE    HA+ +E LT   + + R  + + K+ + L+ +N     
Sbjct: 1202 ----------------QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD--- 1242

Query: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
            L  ELR+   A  E  +K K L+  +Q+ Q++CS  +   A L +   + + + +S    
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM 1302

Query: 1097 LDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQ 1156
            L++  G+  +L + +  L+ +++D +   +      ++ +   +   K RQ E+E    Q
Sbjct: 1303 LNEAEGKAIKLAKDVASLSSQLQDTQELLQ------EETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 1157 -KLESEKAIKEK-EYEIERLRVLLQEEGTRKREYENE---LAKVRNHYNEEMSNLRNKYE 1211
             +L+ E   K+  E  I  L + L +   + +++ +    L + +  + +E+ NL  +YE
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 1212 TE------INITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATE 1265
             +      +  TK  +++       D  N R  +  L ++ R     +    +   +  +
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 1266 QRRRAEENALQQKACG-------SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAK 1318
            +R RAE  A +++           E ++ K+ LE    ++++   ED    K   ++  K
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVSSK---DDVGK 1532

Query: 1319 TIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN---NYDEEIISLKNQFETEINITKT 1375
             + +  K    L+ + +E   +  E E+EL    +     +  + +LK QFE ++     
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592

Query: 1376 TIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKR-----LKNTLTQTTENLRRVEEDI 1430
               +   Q +     Y  ++++  R+ R+L+   K+     LK+   Q    ++  EE I
Sbjct: 1593 QNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 1431 QQQKATGSEVSQRKQQLEVELRQVTQM--RTEESVRYKQSLDDAAKTIQDKNKEIERLKQ 1488
            +Q +   +++   +++LE       ++    +E+ +  +SL+     +Q+     ER ++
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711

Query: 1489 LIDKETND-----------RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR 1537
              D E  +           R  L+DE  RL+     L++      E    ++     + +
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE---ELEEEQGNMEAMSDRVRK 1768

Query: 1538 LRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRL--------KRTASEDSC 1589
                 E++S E   +     + +++ ++L+ Q +++  +L+ +        K T +    
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828

Query: 1590 KRKKLEEELEGMRR-------SLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDG 1642
            K  +LEE++E   R       SLK++  K+  +  Q+E     +++  +  ++Q +  + 
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED----ERKMAEQYKEQAEKGNA 1884

Query: 1643 HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNES 1699
             +++ +R  EE    S  + A RR+L +E +   +++        A++ K R  NE+
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNET 1941



 Score = 38.9 bits (89), Expect = 0.074
 Identities = 56/258 (21%), Positives = 103/258 (39%), Gaps = 38/258 (14%)

Query: 215  EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQN 274
            E+ I   R +   + D++ +L+  +A   E  A  +  E+    L+A       L QLQ 
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD------LMQLQE 1701

Query: 275  IIQATSREIMWINDCEEEELLYDWSDK--------------NTNIAQKQEAFSIRMSQLE 320
             + A  R      D E+EEL  + +                   IAQ +E        +E
Sbjct: 1702 DLAAAERARKQA-DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1760

Query: 321  VKEKELNKLKQESDQL---VLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAA 377
                 + K  Q+++QL   +  +   + K E+    L+ Q   +        +H  E A 
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHEMEGAV 1815

Query: 378  YFQFFEEAQSTEAYLKGLQDSI----RKKYPCDKNMPL--QHLLEQIKELEKEREKILEY 431
              +F     + EA +  L++ +    R+K    K++    + L E + ++E ER+   +Y
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875

Query: 432  KRQVQNLVNKSKKIVQLK 449
            K Q +     + ++ QLK
Sbjct: 1876 KEQAE---KGNARVKQLK 1890



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)

Query: 55   GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
            GY      ++ Q Q T  +++Q NC+  L +R     +   K    +Q+TR  E     +
Sbjct: 806  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 865

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
            +   +  ++ +  ++ ++E+ Q        +K LLQ Q Q    LY      RVR A+ K
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 924

Query: 168  GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
                   +      E    +  E     R Q+ + +       +  +E+ +         
Sbjct: 925  Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 228  IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
            +     QL+K+ A+ + K    +LE+E    +    ++ + L + + +++    ++   N
Sbjct: 976  L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1021

Query: 288  DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
              EEEE       K  N+ + +      +S+LEV+ K+  K +QE ++L    +  ASD 
Sbjct: 1022 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 347  IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
             E   D LQ Q +            LK      Q  ++ +  +A L  L D I +K    
Sbjct: 1075 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1113

Query: 407  KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
                  + L++I+ELE    + ++ L+ +R  +N   K K+
Sbjct: 1114 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  184 bits (466), Expect = 1e-45
 Identities = 242/1166 (20%), Positives = 511/1166 (43%), Gaps = 169/1166 (14%)

Query: 876  FRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHS 935
            +RL+   K + Q+    +  QA    L   K RQ   E+            L E +  HS
Sbjct: 842  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENE-----------LKELEQKHS 890

Query: 936  EISGKRDK-SEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQ 994
            +++ +++   E++Q   EL A + ++  ++LA+    LE +L+    R   +   G  LQ
Sbjct: 891  QLTEEKNLLQEQLQAETELYAEA-EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949

Query: 995  EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNT----KIEVLEEELRLARDANSE 1050
                  A   ++  +  D    L E   + + L+L+      KI+ LE+E+ +  D N++
Sbjct: 950  ------AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 1003

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN-- 1108
               + K L++ +       ++ + K  +L +LK + E                I EL   
Sbjct: 1004 LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE--------------SMISELEVR 1049

Query: 1109 -EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD------QLQKARQCEKENLGWQKLESE 1161
             +K  +   E+E  KR+ +     F +Q  D        ++Q A++ E+      +L+ E
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109

Query: 1162 KAIKEKEYEIERLRVL------LQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEIN 1215
              I +K   ++++R L      LQE+   +R   N+  K +    EE+  L+ + E  ++
Sbjct: 1110 --IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSREN----RDLKDEIVRLNDSILQATEQRRRAE 1271
             T T  +E+  ++E +   L+  LD  +R +    ++++ +  +  + + +  EQ +RA+
Sbjct: 1168 STATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226

Query: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 1331
             N  + K     + ++   L  EL+ V+ Q  ++    K+ LE   + +Q K  + ER +
Sbjct: 1227 ANLDKNK---QTLEKENADLAGELR-VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1282

Query: 1332 AEFQEEAKRRWEYENELSKVRNNYDE----------EIISLKNQFE-TEINITKTTIHQL 1380
            AE  ++  +    +NE+  V    +E          ++ SL +Q + T+  + + T  +L
Sbjct: 1283 AELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1339

Query: 1381 TM-----QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA 1435
             +     Q EE+ +  + Q+D      ++L   I  L   L+ + + L       Q   +
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL-------QDFAS 1392

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRY----------KQSLDDAAKTIQDKNKEIER 1485
            T   + + K++ + E+  +TQ   E++  Y          +Q LDD    + ++ + +  
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452

Query: 1486 LK-------QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR- 1537
            L+       QL+ +E N      DE  R +    + +    S    + +    ++EL R 
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 1538 ---LRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT--ASEDSCKRK 1592
               L+ + E +   +    +++   + S + L+ Q ++++ +L  L+    A+ED+  R 
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 1593 KL--------------------EEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632
            ++                    EE+   ++R L E   ++ +  +Q   A+  KK+ E D
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632

Query: 1633 LRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED- 1691
            L+      D  ++ ++   ++LR+L ++++  +R+L   + S      R+E F  A E+ 
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENE 1686

Query: 1692 -KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN---A 1747
             K++SL    ++++   +  E   K+  + +EEL     E      GR+    +K    A
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE---ELASSLSGRNALQDEKRRLEA 1743

Query: 1748 TILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQ 1807
             I +L  +L+        +   +    ++ E L  E+         A+ R    KN+  +
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL---------ATERSTAQKNESAR 1794

Query: 1808 VVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE-TRVKQRLECEKQQIQNDLNQ 1866
               ER++  ++ K+ E + A   + +  +    + LEA+  ++++++E E ++ Q     
Sbjct: 1795 QQLERQNKELRSKLHEMEGAVKSKFKSTI----AALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K +  + +E + ++E ER+ +E+ K     + E+  A +K++    +R+LE++  E+Q 
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYK----EQAEKGNARVKQL----KRQLEEAEEESQ- 1901

Query: 1927 QLETERSRYQREIDKLRQRPYGSHRE 1952
            ++   R + QRE+D+  +      RE
Sbjct: 1902 RINANRRKLQRELDEATESNEAMGRE 1927



 Score =  182 bits (463), Expect = 3e-45
 Identities = 220/1048 (20%), Positives = 456/1048 (43%), Gaps = 127/1048 (12%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  +++  E+EL+  ++   +  N+ K L+Q
Sbjct: 831  AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 887

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
               +   E +  + +L +  EL  +AE       +   +   + +EL E +  +   +E+
Sbjct: 888  KHSQLTEEKNLLQEQLQAETELYAEAE-------EMRVRLAAKKQELEEILHEMEARLEE 940

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
            E+ R + ++   +++K     L    Q E+E    QKL+ EK   E + +     +L+ +
Sbjct: 941  EEDRGQQLQA--ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998

Query: 1181 EGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIK--------EISMQKEDDS 1232
            +   K   E +L + R   ++  +NL  + E   N+TK   K        E+ ++KE+ S
Sbjct: 999  DQNNKLSKERKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1056

Query: 1233 KNLRNQLDR-LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKA-CGSEIMQKKQH 1290
            +    +L R L  +  D  ++I  L   I +   Q  + EE      A    EI QK   
Sbjct: 1057 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1116

Query: 1291 LEI--ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE-------EAKRR 1341
            L+   EL+  +    ED    + +  +A K  +D  +E+E LK E ++       + + R
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDN---- 1397
             + E E++ ++   DEE  S + Q +         + +LT Q E+     +A +D     
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQT 1235

Query: 1398 LTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS-------EVSQRKQQLEVE 1450
            L +EN  L+ E++ L     +     +++E  +Q+ ++  S       E++ +  +L+ E
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295

Query: 1451 LRQVTQMRTE----------ESVRYKQSLDDAAKTIQDKNKE----IERLKQLIDKETND 1496
            +  VT M  E          +       L D  + +Q++ ++      +L+QL ++  + 
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355

Query: 1497 RKCLEDENARLQRVQYDLQKANSSATETINKL--------------KVQEQELTRLRIDY 1542
            +  L++E    Q ++  +   N   +++  KL              K  ++E+  L   Y
Sbjct: 1356 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415

Query: 1543 ERVSQERTVKDQDITRFQNSLKELQL----QKQKV---EEELNRLKRTASEDSCKRKKLE 1595
            E  +      ++   R Q  L +L +    Q+Q V   E++  +  +  +E+     K  
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475

Query: 1596 EELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE----------DDLRQQRDVLDGHLR 1645
            +E +      +E+  K  +L + LE+A   K+  E          +DL   +D +  ++ 
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535

Query: 1646 EKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI---------------E 1690
            E ++++  L     E++    +L  E ++ + A LR E   +A+               E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 1691 DKSRSLN------ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
            +K R L       E+++E ER Q       K+ L  E +L++L L+ D   +GR EA   
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKL--EGDLKDLELQADSAIKGREEAIKQ 1653

Query: 1745 KN---ATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQES 1801
                 A + + + +L+ +     E+     + +++ ++L  ++ + Q+    A    +++
Sbjct: 1654 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713

Query: 1802 KNQCTQVVQERESLLVKIKVLEQDKARLQ----RLEDELNRAKSTLEAETRVKQRLECEK 1857
              +  ++ +E  S L     L+ +K RL+    +LE+EL   +  +EA +   ++   + 
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q+ N+L       + +    +K ES R++ ER+   LRS++  ++  +K   +     L
Sbjct: 1774 EQLSNEL-------ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            E    + + Q+E E    Q     L+Q+
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQK 1854



 Score =  174 bits (440), Expect = 1e-42
 Identities = 204/987 (20%), Positives = 434/987 (43%), Gaps = 129/987 (13%)

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
            +  +QA C  + A+ A     KRQ +L      Q    C   +K  N +  RL  +++  
Sbjct: 797  IMAFQAMCRGYLARKAFA---KRQQQLTAMKVIQR--NCAAYLKLRNWQWWRLFTKVKPL 851

Query: 1122 KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE-KAIKEKEYEIERLRVLLQE 1180
             +  +  E+   Q K D  Q  K RQ        QK E+E K +++K  ++   + LLQE
Sbjct: 852  LQVTRQEEEM--QAKEDELQKTKERQ--------QKAENELKELEQKHSQLTEEKNLLQE 901

Query: 1181 EGTRKREYENELAKVRNHY---NEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRN 1237
            +   + E   E  ++R       +E+  + ++ E  +            ++ED  + L+ 
Sbjct: 902  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-----------EEEDRGQQLQA 950

Query: 1238 QLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSE----IMQKKQHLEI 1293
            +  +++++  DL++++        +A  Q+ + E+   + K    E    +M  + +   
Sbjct: 951  ERKKMAQQMLDLEEQLEEE-----EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 1294 ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353
            + ++++++R  D   +    EE AK +     + E + +E +   K+  +   EL K++ 
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065

Query: 1354 NYDEEIISLKNQFETEINITKTTIHQLTMQ---KEEDTSGYRAQIDNLTRENRSLSEEIK 1410
              + +     + F  +I   +  I +L MQ   KEE+     A++D+   +  +  ++I+
Sbjct: 1066 KLEGDA----SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1121

Query: 1411 RLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD 1470
             L+  ++        ++ED+  ++A  ++  ++K+ L  EL     ++TE     + +LD
Sbjct: 1122 ELEGHISD-------LQEDLDSERAARNKAEKQKRDLGEELEA---LKTE----LEDTLD 1167

Query: 1471 DAAKTIQ---DKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINK 1527
              A   +    + +E+  LK+ +D+ET   +      A++Q ++    +A    TE + +
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHE------AQVQEMRQKHAQAVEELTEQLEQ 1221

Query: 1528 LKVQEQELTRLRIDYER----VSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT 1583
             K  +  L + +   E+    ++ E  V  Q     ++  K+L+ Q Q+++ + +  +R 
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281

Query: 1584 ASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGH 1643
             +E + K  KL+ E+E +   L E   K   L + +   S         L+  +++L   
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-------SQLQDTQELLQEE 1334

Query: 1644 LREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI 1703
             R+K     +LR+L  E  +L+ QL +E E+        ++ ++ I   +  L++SK ++
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-------KQNLERHISTLNIQLSDSKKKL 1387

Query: 1704 ERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763
            +   S  E L +     ++E+ NL  +Y++      + +  KN                 
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN----------------- 1430

Query: 1764 LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE 1823
              LQ  ++DL  + +N RQ +   +K+  +    + E KN  ++   ER+    + +  E
Sbjct: 1431 -RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489

Query: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQ------------------RLECEKQQIQNDLN 1865
                 L R  +E   AK  LE   ++ +                   LE  K+ ++  + 
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549

Query: 1866 QWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER-LQAEIKRIEERCRRKLEDSTRET 1924
            + KTQ    E+ ++  E  + + E    +L+ + ER LQA  ++ EE+ RR+L+    E 
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK-RRQLQRQLHEY 1608

Query: 1925 QSQLETERSRYQREI-DKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYEC 1983
            +++LE ER   QR +    +++  G  ++ + + +  +   +     LRK    M+ ++ 
Sbjct: 1609 ETELEDERK--QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666

Query: 1984 QLID-KTTLDKLLKGKKSVEEVASEIQ 2009
            +L D + + D++    K  E+ A  ++
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLE 1693



 Score =  172 bits (435), Expect = 6e-42
 Identities = 237/1139 (20%), Positives = 487/1139 (42%), Gaps = 110/1139 (9%)

Query: 770  VRALLQAILQTEDM-LKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            V+ LLQ   Q E+M  K  E + T+E        K E     L++  + L  +K+LL   
Sbjct: 848  VKPLLQVTRQEEEMQAKEDELQKTKERQ-----QKAENELKELEQKHSQLTEEKNLLQEQ 902

Query: 829  ---KTELQ-KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRID---KQIDFRLWDL 881
               +TEL  +A+++  + + +    +  L +   ++ +  DR Q++    K++  ++ DL
Sbjct: 903  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962

Query: 882  EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVM----RFLNEQ-KNLHSE 936
            E+Q+++    R   Q   K   +AK ++   E +   D N  +    + L E+  +L + 
Sbjct: 963  EEQLEEEEAARQKLQLE-KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1021

Query: 937  ISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEA 996
            ++ + +K++ + K+     + I + E++L       + L  +  K   ++  +    ++ 
Sbjct: 1022 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDASDFHEQI 1078

Query: 997  ADVHARYIELLTRSGDYYRFLSEMLKSLED-LKLKNT---KIEVLEEELR-LARDANSEN 1051
            AD+ A+  EL  +       L   L  L+D +  KN    KI  LE  +  L  D +SE 
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 1052 CNKNKF------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDK----CY 1101
              +NK       L + L+  + E        A+ +EL+ + E +    K+ LD+      
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198

Query: 1102 GQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
             Q++E+ +K  +   E+ ++  + K  +   D+ K   ++       E   LG  K E E
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258

Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI 1221
               K+ E +++ L+    +    + E  +++ K++N   E ++ + N+ E +       +
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKDV 1317

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
              +S Q +D  + L+ +    +R+  ++  ++ +L +            E N+LQ +   
Sbjct: 1318 ASLSSQLQDTQELLQEE----TRQKLNVSTKLRQLEE------------ERNSLQDQL-- 1359

Query: 1282 SEIMQKKQHLEIELKQVMQQRSE------DNARHKQSLEEAAKTIQDKNKEIERLKAEFQ 1335
             E M+ KQ+LE  +  +  Q S+      D A   ++LEE  K  Q   KEIE L  +++
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ---KEIENLTQQYE 1416

Query: 1336 EEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT--IHQLTMQKEEDTSGY-- 1391
            E+A    + E   ++++   D+ ++ L NQ +   N+ K      QL  +++  +S Y  
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 1392 ---RAQIDNLTRENRSLS-----EEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQR 1443
               RA+ +   +E ++LS     EE    K  L +T + L+   ED+   K    +V + 
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK---DDVGKN 1533

Query: 1444 KQQLEVELRQV-TQMRTEESVRYKQSLDDAAKTIQDKNKEIE----RLKQLIDKETNDRK 1498
              +LE   R + TQM  EE     + L+D  +  +D    +E     LK   +++   R 
Sbjct: 1534 VHELEKSKRALETQM--EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591

Query: 1499 CLEDENAR-----LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
               +E  R     L   + +L+             K  E +L  L +  +   + R    
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKIT 1613
            + + + Q  +K+ Q + +      + +  TA E+  K K LE +L               
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL--------------M 1697

Query: 1614 NLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673
             L + L  A   +K+++ +  +  + L   L  +   Q+E RRL + +  L  +L +EQ 
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757

Query: 1674 SVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDD 1733
            +++    R     +  E  S  L   +   ++ +S  + L +++  L  +L  +      
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817

Query: 1734 LRRGRSEADSDKNATILELRSQ----LQISNNRTLELQGLINDLQRERENLRQEIEKFQK 1789
              +    A   K A + E   Q     Q +     +    + ++  + E+ R+  E++++
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877

Query: 1790 QALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETR 1848
            QA + + R+++ K Q  +  +E + +    + L+++        + + R  + L+++ R
Sbjct: 1878 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score = 38.9 bits (89), Expect = 0.074
 Identities = 56/258 (21%), Positives = 103/258 (39%), Gaps = 38/258 (14%)

Query: 215  EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQN 274
            E+ I   R +   + D++ +L+  +A   E  A  +  E+    L+A       L QLQ 
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD------LMQLQE 1701

Query: 275  IIQATSREIMWINDCEEEELLYDWSDK--------------NTNIAQKQEAFSIRMSQLE 320
             + A  R      D E+EEL  + +                   IAQ +E        +E
Sbjct: 1702 DLAAAERARKQA-DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1760

Query: 321  VKEKELNKLKQESDQL---VLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAA 377
                 + K  Q+++QL   +  +   + K E+    L+ Q   +        +H  E A 
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHEMEGAV 1815

Query: 378  YFQFFEEAQSTEAYLKGLQDSI----RKKYPCDKNMPL--QHLLEQIKELEKEREKILEY 431
              +F     + EA +  L++ +    R+K    K++    + L E + ++E ER+   +Y
Sbjct: 1816 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1875

Query: 432  KRQVQNLVNKSKKIVQLK 449
            K Q +     + ++ QLK
Sbjct: 1876 KEQAE---KGNARVKQLK 1890



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)

Query: 55   GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
            GY      ++ Q Q T  +++Q NC+  L +R     +   K    +Q+TR  E     +
Sbjct: 806  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 865

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
            +   +  ++ +  ++ ++E+ Q        +K LLQ Q Q    LY      RVR A+ K
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 924

Query: 168  GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
                   +      E    +  E     R Q+ + +       +  +E+ +         
Sbjct: 925  Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

Query: 228  IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
            +     QL+K+ A+ + K    +LE+E    +    ++ + L + + +++    ++   N
Sbjct: 976  L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1021

Query: 288  DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
              EEEE       K  N+ + +      +S+LEV+ K+  K +QE ++L    +  ASD 
Sbjct: 1022 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 347  IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
             E   D LQ Q +            LK      Q  ++ +  +A L  L D I +K    
Sbjct: 1075 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1113

Query: 407  KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
                  + L++I+ELE    + ++ L+ +R  +N   K K+
Sbjct: 1114 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1149


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  184 bits (466), Expect = 1e-45
 Identities = 242/1166 (20%), Positives = 511/1166 (43%), Gaps = 169/1166 (14%)

Query: 876  FRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHS 935
            +RL+   K + Q+    +  QA    L   K RQ   E+            L E +  HS
Sbjct: 835  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENE-----------LKELEQKHS 883

Query: 936  EISGKRDK-SEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQ 994
            +++ +++   E++Q   EL A + ++  ++LA+    LE +L+    R   +   G  LQ
Sbjct: 884  QLTEEKNLLQEQLQAETELYAEA-EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942

Query: 995  EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNT----KIEVLEEELRLARDANSE 1050
                  A   ++  +  D    L E   + + L+L+      KI+ LE+E+ +  D N++
Sbjct: 943  ------AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNK 996

Query: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN-- 1108
               + K L++ +       ++ + K  +L +LK + E                I EL   
Sbjct: 997  LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE--------------SMISELEVR 1042

Query: 1109 -EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYD------QLQKARQCEKENLGWQKLESE 1161
             +K  +   E+E  KR+ +     F +Q  D        ++Q A++ E+      +L+ E
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102

Query: 1162 KAIKEKEYEIERLRVL------LQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEIN 1215
              I +K   ++++R L      LQE+   +R   N+  K +    EE+  L+ + E  ++
Sbjct: 1103 --IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSREN----RDLKDEIVRLNDSILQATEQRRRAE 1271
             T T  +E+  ++E +   L+  LD  +R +    ++++ +  +  + + +  EQ +RA+
Sbjct: 1161 STATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219

Query: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLK 1331
             N  + K     + ++   L  EL+ V+ Q  ++    K+ LE   + +Q K  + ER +
Sbjct: 1220 ANLDKNK---QTLEKENADLAGELR-VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275

Query: 1332 AEFQEEAKRRWEYENELSKVRNNYDE----------EIISLKNQFE-TEINITKTTIHQL 1380
            AE  ++  +    +NE+  V    +E          ++ SL +Q + T+  + + T  +L
Sbjct: 1276 AELNDKVHK---LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL 1332

Query: 1381 TM-----QKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKA 1435
             +     Q EE+ +  + Q+D      ++L   I  L   L+ + + L       Q   +
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL-------QDFAS 1385

Query: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRY----------KQSLDDAAKTIQDKNKEIER 1485
            T   + + K++ + E+  +TQ   E++  Y          +Q LDD    + ++ + +  
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445

Query: 1486 LK-------QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTR- 1537
            L+       QL+ +E N      DE  R +    + +    S    + +    ++EL R 
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 1538 ---LRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT--ASEDSCKRK 1592
               L+ + E +   +    +++   + S + L+ Q ++++ +L  L+    A+ED+  R 
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 1593 KL--------------------EEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632
            ++                    EE+   ++R L E   ++ +  +Q   A+  KK+ E D
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625

Query: 1633 LRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED- 1691
            L+      D  ++ ++   ++LR+L ++++  +R+L   + S      R+E F  A E+ 
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENE 1679

Query: 1692 -KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKN---A 1747
             K++SL    ++++   +  E   K+  + +EEL     E      GR+    +K    A
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE---ELASSLSGRNALQDEKRRLEA 1736

Query: 1748 TILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQ 1807
             I +L  +L+        +   +    ++ E L  E+         A+ R    KN+  +
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL---------ATERSTAQKNESAR 1787

Query: 1808 VVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE-TRVKQRLECEKQQIQNDLNQ 1866
               ER++  ++ K+ E + A   + +  +    + LEA+  ++++++E E ++ Q     
Sbjct: 1788 QQLERQNKELRSKLHEMEGAVKSKFKSTI----AALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926
             K +  + +E + ++E ER+ +E+ K     + E+  A +K++    +R+LE++  E+Q 
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYK----EQAEKGNARVKQL----KRQLEEAEEESQ- 1894

Query: 1927 QLETERSRYQREIDKLRQRPYGSHRE 1952
            ++   R + QRE+D+  +      RE
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGRE 1920



 Score =  182 bits (463), Expect = 3e-45
 Identities = 220/1048 (20%), Positives = 456/1048 (43%), Gaps = 127/1048 (12%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  +++  E+EL+  ++   +  N+ K L+Q
Sbjct: 824  AAYLKL--RNWQWWRLFTKV-KPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ 880

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
               +   E +  + +L +  EL  +AE       +   +   + +EL E +  +   +E+
Sbjct: 881  KHSQLTEEKNLLQEQLQAETELYAEAE-------EMRVRLAAKKQELEEILHEMEARLEE 933

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQE 1180
            E+ R + ++   +++K     L    Q E+E    QKL+ EK   E + +     +L+ +
Sbjct: 934  EEDRGQQLQA--ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991

Query: 1181 EGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIK--------EISMQKEDDS 1232
            +   K   E +L + R   ++  +NL  + E   N+TK   K        E+ ++KE+ S
Sbjct: 992  DQNNKLSKERKLLEER--ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS 1049

Query: 1233 KNLRNQLDR-LSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKA-CGSEIMQKKQH 1290
            +    +L R L  +  D  ++I  L   I +   Q  + EE      A    EI QK   
Sbjct: 1050 RQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNA 1109

Query: 1291 LEI--ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE-------EAKRR 1341
            L+   EL+  +    ED    + +  +A K  +D  +E+E LK E ++       + + R
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169

Query: 1342 WEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDN---- 1397
             + E E++ ++   DEE  S + Q +         + +LT Q E+     +A +D     
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQT 1228

Query: 1398 LTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS-------EVSQRKQQLEVE 1450
            L +EN  L+ E++ L     +     +++E  +Q+ ++  S       E++ +  +L+ E
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288

Query: 1451 LRQVTQMRTE----------ESVRYKQSLDDAAKTIQDKNKE----IERLKQLIDKETND 1496
            +  VT M  E          +       L D  + +Q++ ++      +L+QL ++  + 
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348

Query: 1497 RKCLEDENARLQRVQYDLQKANSSATETINKL--------------KVQEQELTRLRIDY 1542
            +  L++E    Q ++  +   N   +++  KL              K  ++E+  L   Y
Sbjct: 1349 QDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408

Query: 1543 ERVSQERTVKDQDITRFQNSLKELQL----QKQKV---EEELNRLKRTASEDSCKRKKLE 1595
            E  +      ++   R Q  L +L +    Q+Q V   E++  +  +  +E+     K  
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468

Query: 1596 EELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE----------DDLRQQRDVLDGHLR 1645
            +E +      +E+  K  +L + LE+A   K+  E          +DL   +D +  ++ 
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528

Query: 1646 EKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAI---------------E 1690
            E ++++  L     E++    +L  E ++ + A LR E   +A+               E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 1691 DKSRSLN------ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744
            +K R L       E+++E ER Q       K+ L  E +L++L L+ D   +GR EA   
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKL--EGDLKDLELQADSAIKGREEAIKQ 1646

Query: 1745 KN---ATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQES 1801
                 A + + + +L+ +     E+     + +++ ++L  ++ + Q+    A    +++
Sbjct: 1647 LRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706

Query: 1802 KNQCTQVVQERESLLVKIKVLEQDKARLQ----RLEDELNRAKSTLEAETRVKQRLECEK 1857
              +  ++ +E  S L     L+ +K RL+    +LE+EL   +  +EA +   ++   + 
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766

Query: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917
            +Q+ N+L       + +    +K ES R++ ER+   LRS++  ++  +K   +     L
Sbjct: 1767 EQLSNEL-------ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 1918 EDSTRETQSQLETERSRYQREIDKLRQR 1945
            E    + + Q+E E    Q     L+Q+
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQK 1847



 Score =  174 bits (440), Expect = 1e-42
 Identities = 204/987 (20%), Positives = 434/987 (43%), Gaps = 129/987 (13%)

Query: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121
            +  +QA C  + A+ A     KRQ +L      Q    C   +K  N +  RL  +++  
Sbjct: 790  IMAFQAMCRGYLARKAFA---KRQQQLTAMKVIQR--NCAAYLKLRNWQWWRLFTKVKPL 844

Query: 1122 KRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE-KAIKEKEYEIERLRVLLQE 1180
             +  +  E+   Q K D  Q  K RQ        QK E+E K +++K  ++   + LLQE
Sbjct: 845  LQVTRQEEEM--QAKEDELQKTKERQ--------QKAENELKELEQKHSQLTEEKNLLQE 894

Query: 1181 EGTRKREYENELAKVRNHY---NEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRN 1237
            +   + E   E  ++R       +E+  + ++ E  +            ++ED  + L+ 
Sbjct: 895  QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-----------EEEDRGQQLQA 943

Query: 1238 QLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSE----IMQKKQHLEI 1293
            +  +++++  DL++++        +A  Q+ + E+   + K    E    +M  + +   
Sbjct: 944  ERKKMAQQMLDLEEQLEEE-----EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 1294 ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353
            + ++++++R  D   +    EE AK +     + E + +E +   K+  +   EL K++ 
Sbjct: 999  KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058

Query: 1354 NYDEEIISLKNQFETEINITKTTIHQLTMQ---KEEDTSGYRAQIDNLTRENRSLSEEIK 1410
              + +     + F  +I   +  I +L MQ   KEE+     A++D+   +  +  ++I+
Sbjct: 1059 KLEGDA----SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR 1114

Query: 1411 RLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLD 1470
             L+  ++        ++ED+  ++A  ++  ++K+ L  EL     ++TE     + +LD
Sbjct: 1115 ELEGHISD-------LQEDLDSERAARNKAEKQKRDLGEELEA---LKTE----LEDTLD 1160

Query: 1471 DAAKTIQ---DKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINK 1527
              A   +    + +E+  LK+ +D+ET   +      A++Q ++    +A    TE + +
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHE------AQVQEMRQKHAQAVEELTEQLEQ 1214

Query: 1528 LKVQEQELTRLRIDYER----VSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRT 1583
             K  +  L + +   E+    ++ E  V  Q     ++  K+L+ Q Q+++ + +  +R 
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274

Query: 1584 ASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGH 1643
             +E + K  KL+ E+E +   L E   K   L + +   S         L+  +++L   
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS-------SQLQDTQELLQEE 1327

Query: 1644 LREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEI 1703
             R+K     +LR+L  E  +L+ QL +E E+        ++ ++ I   +  L++SK ++
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEA-------KQNLERHISTLNIQLSDSKKKL 1380

Query: 1704 ERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT 1763
            +   S  E L +     ++E+ NL  +Y++      + +  KN                 
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN----------------- 1423

Query: 1764 LELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLE 1823
              LQ  ++DL  + +N RQ +   +K+  +    + E KN  ++   ER+    + +  E
Sbjct: 1424 -RLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482

Query: 1824 QDKARLQRLEDELNRAKSTLEAETRVKQ------------------RLECEKQQIQNDLN 1865
                 L R  +E   AK  LE   ++ +                   LE  K+ ++  + 
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542

Query: 1866 QWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER-LQAEIKRIEERCRRKLEDSTRET 1924
            + KTQ    E+ ++  E  + + E    +L+ + ER LQA  ++ EE+ RR+L+    E 
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK-RRQLQRQLHEY 1601

Query: 1925 QSQLETERSRYQREI-DKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYEC 1983
            +++LE ER   QR +    +++  G  ++ + + +  +   +     LRK    M+ ++ 
Sbjct: 1602 ETELEDERK--QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659

Query: 1984 QLID-KTTLDKLLKGKKSVEEVASEIQ 2009
            +L D + + D++    K  E+ A  ++
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLE 1686



 Score =  172 bits (435), Expect = 6e-42
 Identities = 237/1139 (20%), Positives = 487/1139 (42%), Gaps = 110/1139 (9%)

Query: 770  VRALLQAILQTEDM-LKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828
            V+ LLQ   Q E+M  K  E + T+E        K E     L++  + L  +K+LL   
Sbjct: 841  VKPLLQVTRQEEEMQAKEDELQKTKERQ-----QKAENELKELEQKHSQLTEEKNLLQEQ 895

Query: 829  ---KTELQ-KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRID---KQIDFRLWDL 881
               +TEL  +A+++  + + +    +  L +   ++ +  DR Q++    K++  ++ DL
Sbjct: 896  LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955

Query: 882  EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVM----RFLNEQ-KNLHSE 936
            E+Q+++    R   Q   K   +AK ++   E +   D N  +    + L E+  +L + 
Sbjct: 956  EEQLEEEEAARQKLQLE-KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN 1014

Query: 937  ISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEA 996
            ++ + +K++ + K+     + I + E++L       + L  +  K   ++  +    ++ 
Sbjct: 1015 LAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK---LEGDASDFHEQI 1071

Query: 997  ADVHARYIELLTRSGDYYRFLSEMLKSLED-LKLKNT---KIEVLEEELR-LARDANSEN 1051
            AD+ A+  EL  +       L   L  L+D +  KN    KI  LE  +  L  D +SE 
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 1052 CNKNKF------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDK----CY 1101
              +NK       L + L+  + E        A+ +EL+ + E +    K+ LD+      
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191

Query: 1102 GQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
             Q++E+ +K  +   E+ ++  + K  +   D+ K   ++       E   LG  K E E
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251

Query: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI 1221
               K+ E +++ L+    +    + E  +++ K++N   E ++ + N+ E +       +
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV-ESVTGMLNEAEGKAIKLAKDV 1310

Query: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
              +S Q +D  + L+ +    +R+  ++  ++ +L +            E N+LQ +   
Sbjct: 1311 ASLSSQLQDTQELLQEE----TRQKLNVSTKLRQLEE------------ERNSLQDQL-- 1352

Query: 1282 SEIMQKKQHLEIELKQVMQQRSE------DNARHKQSLEEAAKTIQDKNKEIERLKAEFQ 1335
             E M+ KQ+LE  +  +  Q S+      D A   ++LEE  K  Q   KEIE L  +++
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQ---KEIENLTQQYE 1409

Query: 1336 EEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTT--IHQLTMQKEEDTSGY-- 1391
            E+A    + E   ++++   D+ ++ L NQ +   N+ K      QL  +++  +S Y  
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 1392 ---RAQIDNLTRENRSLS-----EEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQR 1443
               RA+ +   +E ++LS     EE    K  L +T + L+   ED+   K    +V + 
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK---DDVGKN 1526

Query: 1444 KQQLEVELRQV-TQMRTEESVRYKQSLDDAAKTIQDKNKEIE----RLKQLIDKETNDRK 1498
              +LE   R + TQM  EE     + L+D  +  +D    +E     LK   +++   R 
Sbjct: 1527 VHELEKSKRALETQM--EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584

Query: 1499 CLEDENAR-----LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553
               +E  R     L   + +L+             K  E +L  L +  +   + R    
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKIT 1613
            + + + Q  +K+ Q + +      + +  TA E+  K K LE +L               
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADL--------------M 1690

Query: 1614 NLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673
             L + L  A   +K+++ +  +  + L   L  +   Q+E RRL + +  L  +L +EQ 
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750

Query: 1674 SVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDD 1733
            +++    R     +  E  S  L   +   ++ +S  + L +++  L  +L  +      
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810

Query: 1734 LRRGRSEADSDKNATILELRSQ----LQISNNRTLELQGLINDLQRERENLRQEIEKFQK 1789
              +    A   K A + E   Q     Q +     +    + ++  + E+ R+  E++++
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870

Query: 1790 QALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETR 1848
            QA + + R+++ K Q  +  +E + +    + L+++        + + R  + L+++ R
Sbjct: 1871 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score = 38.9 bits (89), Expect = 0.074
 Identities = 56/258 (21%), Positives = 103/258 (39%), Gaps = 38/258 (14%)

Query: 215  EQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQN 274
            E+ I   R +   + D++ +L+  +A   E  A  +  E+    L+A       L QLQ 
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD------LMQLQE 1694

Query: 275  IIQATSREIMWINDCEEEELLYDWSDK--------------NTNIAQKQEAFSIRMSQLE 320
             + A  R      D E+EEL  + +                   IAQ +E        +E
Sbjct: 1695 DLAAAERARKQA-DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNME 1753

Query: 321  VKEKELNKLKQESDQL---VLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAA 377
                 + K  Q+++QL   +  +   + K E+    L+ Q   +        +H  E A 
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHEMEGAV 1808

Query: 378  YFQFFEEAQSTEAYLKGLQDSI----RKKYPCDKNMPL--QHLLEQIKELEKEREKILEY 431
              +F     + EA +  L++ +    R+K    K++    + L E + ++E ER+   +Y
Sbjct: 1809 KSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQY 1868

Query: 432  KRQVQNLVNKSKKIVQLK 449
            K Q +     + ++ QLK
Sbjct: 1869 KEQAE---KGNARVKQLK 1883



 Score = 35.8 bits (81), Expect = 0.63
 Identities = 87/401 (21%), Positives = 165/401 (41%), Gaps = 68/401 (16%)

Query: 55   GYCQTGTMSRHQNQNTIQELLQ-NCSDCL-MRAELIVQPELKYGDGIQLTRSRE----LD 108
            GY      ++ Q Q T  +++Q NC+  L +R     +   K    +Q+TR  E     +
Sbjct: 799  GYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKE 858

Query: 109  ECFAQANDQMEILDSLIREMRQMGQPCDAYQKRLLQLQEQMRA-LYKAISVPRVRRASSK 167
            +   +  ++ +  ++ ++E+ Q        +K LLQ Q Q    LY      RVR A+ K
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQLQAETELYAEAEEMRVRLAAKK 917

Query: 168  GGGGYTCQSGSGWDEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNS 227
                   +      E    +  E     R Q+ + +       +  +E+ +         
Sbjct: 918  Q------ELEEILHEMEARLEEE---EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968

Query: 228  IGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWIN 287
            +     QL+K+ A+ + K    +LE+E    +    ++ + L + + +++    ++   N
Sbjct: 969  L-----QLEKVTAEAKIK----KLEDE----ILVMDDQNNKLSKERKLLEERISDLT-TN 1014

Query: 288  DCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLN-QHPASDK 346
              EEEE       K  N+ + +      +S+LEV+ K+  K +QE ++L    +  ASD 
Sbjct: 1015 LAEEEE-------KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 347  IEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCD 406
             E   D LQ Q +            LK      Q  ++ +  +A L  L D I +K    
Sbjct: 1068 HEQIAD-LQAQIA-----------ELK-----MQLAKKEEELQAALARLDDEIAQK---- 1106

Query: 407  KNMPLQHLLEQIKELE---KEREKILEYKRQVQNLVNKSKK 444
                  + L++I+ELE    + ++ L+ +R  +N   K K+
Sbjct: 1107 -----NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR 1142


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  183 bits (465), Expect = 2e-45
 Identities = 221/1043 (21%), Positives = 470/1043 (45%), Gaps = 136/1043 (13%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R   ++R  +++ K L  +  +  +++  +EEL   ++  ++   + + +++
Sbjct: 824  AAYLKL--RHWQWWRVFTKV-KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMER 880

Query: 1061 NLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED 1120
              Q+   E      K    E+L+ + EL  + A++   +   + +EL E +  L   +E+
Sbjct: 881  KHQQLLEE------KNILAEQLQAETELFAE-AEEMRARLAAKKQELEEILHDLESRVEE 933

Query: 1121 EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKE-KEYEIERLRVLLQ 1179
            E+ R + +++   + +     L++  Q ++E    QKL+ EK   E K  ++E   +LL+
Sbjct: 934  EEERNQILQNEKKKMQAHIQDLEE--QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLE 991

Query: 1180 EEGTR----KREYENELAKVRNHYNEE------MSNLRNKYETEINITKTTIKEISMQKE 1229
            ++ ++    K+  E+ +A+  +   EE      ++ +RNK E  I+  +  +K+    ++
Sbjct: 992  DQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQ 1051

Query: 1230 DDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGS-EIMQKK 1288
            +  K  R    +L  E  DL+D+I  L   I +   Q  + EE      A G  E + K 
Sbjct: 1052 ELEKAKR----KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107

Query: 1289 QHLEI--ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQE-------EAK 1339
              L++  EL+  + +  ED    K S  +A K  +D ++E+E LK E ++       + +
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167

Query: 1340 RRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDN-- 1397
             R + E E+++++   +EE  + + Q +       T + +L+ Q E+    ++A ++   
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQ-AKRFKANLEKNK 1226

Query: 1398 --LTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSE-------VSQRKQQLE 1448
              L  +N+ L+ E+K L+    ++    ++++  +Q+  A  SE       ++++  +L+
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286

Query: 1449 VELRQVTQMRTE----------ESVRYKQSLDDAAKTIQDKNKE----IERLKQLIDK-- 1492
             EL  V+ +  E          ++   +  L D  + +Q++ ++      R++QL ++  
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346

Query: 1493 --------ETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYER 1544
                    E   RK LE +   LQ    D +K       TI  L+  +++L +   D E 
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK---DAEA 1403

Query: 1545 VSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLE--------- 1595
            +SQ    K     + + +   LQ +   +  +L+  ++ AS    K+KK +         
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463

Query: 1596 -----EELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE----------DDLRQQRDVL 1640
                 EE +      +E+  K  +L + LE+A   K+  E          +DL   +D +
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523

Query: 1641 DGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESK 1700
              ++ E ++++  L +   E+     +L  E ++ + A LR E   +A+          K
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM----------K 1573

Query: 1701 IEIER-LQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELR---SQL 1756
             + ER LQ+  E   ++  +L +++R L  E +D R+ R+ A + K    ++L+   +Q+
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI 1633

Query: 1757 QISNNRTLE-------LQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVV 1809
            + +N    E       LQ  + D QRE E  R   ++   Q+ E+  +++  + +  Q+ 
Sbjct: 1634 EAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQ 1693

Query: 1810 QERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKT 1869
            +E  S     +  EQ++     L DE+  + S   A    K+RLE    Q++ +L + ++
Sbjct: 1694 EELASSERARRHAEQER---DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750

Query: 1870 QYSRKEEAIRK-----------IESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLE 1918
                  +  RK           + +ER  +++  N+ R ++ER   E+K   +     ++
Sbjct: 1751 NMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA-RQQLERQNKELKAKLQELEGAVK 1809

Query: 1919 DSTRETQSQLETERSRYQREIDK 1941
               + T S LE +  + + ++++
Sbjct: 1810 SKFKATISALEAKIGQLEEQLEQ 1832



 Score =  173 bits (438), Expect = 3e-42
 Identities = 241/1169 (20%), Positives = 497/1169 (42%), Gaps = 180/1169 (15%)

Query: 876  FRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHS 935
            +R++   K + Q+    +  QA  + L   K +Q  +E             L E +  H 
Sbjct: 835  WRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGE-----------LEEMERKHQ 883

Query: 936  EISGKRD-KSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQ 994
            ++  +++  +E++Q   EL A + ++   +LA+    LE +L+    R   +     ILQ
Sbjct: 884  QLLEEKNILAEQLQAETELFAEA-EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ 942

Query: 995  EAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNK 1054
                    +I+ L    D      + L+ LE +  +  KI+ +EEE+ L  D NS+   +
Sbjct: 943  NEKKKMQAHIQDLEEQLDEEEGARQKLQ-LEKVTAE-AKIKKMEEEILLLEDQNSKFIKE 1000

Query: 1055 NKFLDQNLQKYQAECSQFKAKLASLEELKRQAEL----------DGKSAKQNLDKCY--- 1101
             K ++  + +  ++ ++ + K  +L +++ + E+            +  +Q L+K     
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060

Query: 1102 -GQIKELNEKITRLTYEIEDEKRRRKSVEDRF--------DQQKNDYDQLQKARQCEKEN 1152
             G+  +L ++I  L  +I++ K +    E+          D+  +  + L+  R+ + + 
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120

Query: 1153 LGWQK-LESEKAIKEK--------EYEIERLRVLLQE-------EGTRKREYENELAKVR 1196
               Q+  ESEKA + K          E+E L+  L++       +   + + E E+A+++
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180

Query: 1197 NHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSK---NLRNQLDRLSRENRDLKDEI 1253
                EE  N   + +       T ++E+S Q E   +   NL      L  +N++L  E+
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240

Query: 1254 VRLNDSILQATEQRRRAEENALQQKACGSE-------IMQKKQHLEIELKQVMQQRSE-- 1304
              L     ++  +R++ +    +  A  SE       + +K   L+ EL  V     E  
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300

Query: 1305 --------DNARHKQSLEEAAKTIQDKNKEIERLKA---EFQEEAKRRWEYENELSKVRN 1353
                    D A  +  L++  + +Q++ ++   L +   + +EE     E + E  + R 
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARK 1360

Query: 1354 NYDEEIISLKNQF---ETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLS-EEI 1409
            N ++++++L++Q    + +++    TI  L   K++      A    L  E ++L+ +++
Sbjct: 1361 NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRL--EEKALAYDKL 1418

Query: 1410 KRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRK-QQLEVELRQVTQMRTEESVRYKQS 1468
            ++ KN L Q  ++L  V+ D Q+Q A+  E  Q+K  QL  E + +       S RY + 
Sbjct: 1419 EKTKNRLQQELDDLT-VDLDHQRQVASNLEKKQKKFDQLLAEEKSI-------SARYAEE 1470

Query: 1469 LDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKL 1528
             D A    ++K  +   L + +++    ++  E +N +L+    DL  +     + +++L
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530

Query: 1529 ----KVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTA 1584
                +  EQ++  +R   E +  E    +    R      E+ +Q  K + E +   R  
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL-----EVNMQAMKAQFERDLQTRDE 1585

Query: 1585 SEDSCKR------KKLEEELEGMRR-------SLKEQAIKITNLTQQLEQASIVKKRSED 1631
              +  KR      ++LE ELE  R+       S K+  I + +L  Q+E A+    ++ D
Sbjct: 1586 QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN----KARD 1641

Query: 1632 DLRQQRDVLDGHLREKQRTQEELRRLSSEV-----------EALRRQLLQEQESVKQAHL 1680
            ++ +Q   L   +++ QR  EE R    E+           ++L  ++LQ QE +  +  
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701

Query: 1681 RNEHFQKAIEDKSRSLNESKI-------EIERLQSLTENLTKEHLMLEEELRNLRLEYDD 1733
               H ++  ++ +  +  S         E  RL++    L +E   LEEE  N+ L  D 
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE---LEEEQSNMELLNDR 1758

Query: 1734 LRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIE-KFQKQAL 1792
             R+   + D+  NA +   RS  Q S+N   +L+    +L+ + + L   ++ KF+    
Sbjct: 1759 FRKTTLQVDT-LNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817

Query: 1793 EASNRIQESKNQCTQVVQERESLLVKIKVLEQD-KARLQRLEDELNRAKSTLEAETRVKQ 1851
                +I + + Q  Q  +ER +    ++  E+  K    ++EDE   A            
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA------------ 1865

Query: 1852 RLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEE 1911
                         +Q+K Q  +    +++++ + E++E E     +   +LQ        
Sbjct: 1866 -------------DQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ-------- 1904

Query: 1912 RCRRKLEDSTRETQS---QLETERSRYQR 1937
               R+L+D+T   +    ++ T ++R +R
Sbjct: 1905 ---RELDDATEANEGLSREVSTLKNRLRR 1930



 Score =  163 bits (412), Expect = 3e-39
 Identities = 239/1194 (20%), Positives = 505/1194 (42%), Gaps = 123/1194 (10%)

Query: 770  VRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM- 828
            V+ LLQ   Q E++    E  L  +E       KVE     +++    L  +K++LA   
Sbjct: 841  VKPLLQVTRQEEELQAKDEELLKVKEKQT----KVEGELEEMERKHQQLLEEKNILAEQL 896

Query: 829  --KTEL-QKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRID---KQIDFRLWDLE 882
              +TEL  +A+++ ++ + +    +  L     +V +  +R Q +    K++   + DLE
Sbjct: 897  QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956

Query: 883  KQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLH-------S 935
            +Q+ +    R   Q   K   +AK ++   E +   D N+  +F+ E+K +        S
Sbjct: 957  EQLDEEEGARQKLQLE-KVTAEAKIKKMEEEILLLEDQNS--KFIKEKKLMEDRIAECSS 1013

Query: 936  EISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQE 995
            +++ + +K++ + KI       I D E +L       +T   +   +  +   +  +  +
Sbjct: 1014 QLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE---KTRQELEKAKRKLDGETTDLQDQ 1070

Query: 996  AADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL-KNTKIEVLEEE----LRLARDANSE 1050
             A++ A+  EL  +       L   L   +D  L KN  ++V+ E       L  D  SE
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130

Query: 1051 NCNKNKF------LDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDK----C 1100
              ++NK       L + L+  + E        A+ +EL+ + E +    K+ L++     
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190

Query: 1101 YGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLES 1160
              QI+++ ++      E+ ++  + K  +   ++ K   +   K   CE + L   K ES
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250

Query: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTT 1220
            E   K+ + +++ L   + E    + E   + +K++N  +   + L    +  I   K  
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK-- 1308

Query: 1221 IKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAC 1280
                      D+ +L +QL       ++   + + L+  I Q  E++   +E   +++  
Sbjct: 1309 ----------DAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358

Query: 1281 GSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKR 1340
               + ++   L+ +L    +++ +D+    +SLEEA K +    K+ E L    +E+A  
Sbjct: 1359 RKNLEKQVLALQSQLADT-KKKVDDDLGTIESLEEAKKKLL---KDAEALSQRLEEKALA 1414

Query: 1341 RWEYENELSKVRNNYDEEIISLKNQFETEINITKTT--IHQLTMQKEEDTSGY-----RA 1393
              + E   ++++   D+  + L +Q +   N+ K      QL  +++  ++ Y     RA
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474

Query: 1394 QIDNLTRENRSLS-----EEIKRLKNTLTQTTENLRRVEEDIQQQKA-TGSEVSQRKQQL 1447
            + +   +E ++LS     EE    K    +  + LR   ED+   K   G  V + ++  
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534

Query: 1448 EVELRQVTQMRT--EESVRYKQSLDDAAKTI----QDKNKEIERLKQLIDKETNDRKCLE 1501
                +QV +MRT  EE     Q+ +DA   +    Q    + ER  Q  D++  ++K L 
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594

Query: 1502 DENAR-LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ 1560
             +  R L+    D +K  + A  +  K+++  ++L   +I+    +++  +K        
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLKDL-EAQIEAANKARDEVIKQ------- 1646

Query: 1561 NSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620
              L++LQ Q +  + EL   + +  E   + K+ E++L+ +         +I  L ++L 
Sbjct: 1647 --LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEA-------EILQLQEELA 1697

Query: 1621 QASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHL 1680
             +   ++ +E +  +  D +      K    +E RRL + +  L  +L +EQ +++   L
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNME---L 1754

Query: 1681 RNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE 1740
             N+ F+K     +  ++    E+   +S  +        LE + + L+ +  +L      
Sbjct: 1755 LNDRFRKT----TLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL---EGA 1807

Query: 1741 ADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQE 1800
              S   ATI  L +++        +L+  +    +ER    + + + +K+  E   ++++
Sbjct: 1808 VKSKFKATISALEAKIG-------QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED 1860

Query: 1801 SKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKST-------LEAETRVKQRL 1853
             +    Q  ++ E    ++K L   K +L+  E+E  RA ++       L+  T   + L
Sbjct: 1861 ERRHADQYKEQMEKANARMKQL---KRQLEEAEEEATRANASRRKLQRELDDATEANEGL 1917

Query: 1854 ECEKQQIQNDLNQ-WKTQYSRKEEAIRKIESE---REKSEREKNSLRSEIERLQ 1903
              E   ++N L +     +S      R++  E    E S+ +  S  S++   Q
Sbjct: 1918 SREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQ 1971



 Score =  158 bits (400), Expect = 6e-38
 Identities = 199/1011 (19%), Positives = 429/1011 (42%), Gaps = 125/1011 (12%)

Query: 1065 YQAECSQFKAK---------LASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLT 1115
            +QA C  + A+         L++L+ L+R      K       + + ++K L + +TR  
Sbjct: 793  FQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQ-VTRQE 851

Query: 1116 YEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQ--CEKENLGWQKLESEKAIKEKEYEIER 1173
             E++ +      V+++  + + + +++++  Q   E++N+  ++L++E    E   E E 
Sbjct: 852  EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET---ELFAEAEE 908

Query: 1174 LRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSK 1233
            +R  L     +K+E E  L  + +   EE        E    I +   K++    +D   
Sbjct: 909  MRARL---AAKKQELEEILHDLESRVEEE--------EERNQILQNEKKKMQAHIQD--- 954

Query: 1234 NLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEI 1293
             L  QLD      + L+ E V     I       ++ EE  L  +   S+ +++K+ +E 
Sbjct: 955  -LEEQLDEEEGARQKLQLEKVTAEAKI-------KKMEEEILLLEDQNSKFIKEKKLMED 1006

Query: 1294 ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353
             + +   Q +E+        EE AK +     + E + ++ +E  K+  +   EL K + 
Sbjct: 1007 RIAECSSQLAEE--------EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKR 1058

Query: 1354 NYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLK 1413
              D E   L++Q   E+      +     +KEE+  G  A+ D+ T    +  + ++ L+
Sbjct: 1059 KLDGETTDLQDQI-AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117

Query: 1414 NTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAA 1473
              + +       ++ED + +KA+ ++  ++K+ L  EL     ++TE     + +LD  A
Sbjct: 1118 AQIAE-------LQEDFESEKASRNKAEKQKRDLSEELEA---LKTE----LEDTLDTTA 1163

Query: 1474 KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQ-- 1531
               + + K  + + +L       +K LE+E    +    D+++ +++A E +++   Q  
Sbjct: 1164 AQQELRTKREQEVAEL-------KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216

Query: 1532 ------EQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTAS 1585
                  E+    L  D + ++ E  V  Q     ++  K+L  Q Q++  +++   R   
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276

Query: 1586 EDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLR 1645
            E + K  KL+ EL+ +   L+E   K     +  + AS+     E  L+  +++L    R
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAK--DAASL-----ESQLQDTQELLQEETR 1329

Query: 1646 EKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIER 1705
            +K      +R+L  E  +L+ Q  +E+E+ K    +    Q  + D  + +++    IE 
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389

Query: 1706 LQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLE 1765
            L+   + L K+   L + L    L YD L + ++    + +   ++L  Q Q+++N    
Sbjct: 1390 LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN---- 1445

Query: 1766 LQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQD 1825
                              +EK QK+       + E K+   +  +ER+    + +  E  
Sbjct: 1446 ------------------LEKKQKKF---DQLLAEEKSISARYAEERDRAEAEAREKETK 1484

Query: 1826 KARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESER 1885
               L R           LE     K+  E + +Q++ D+    +      + + ++E  +
Sbjct: 1485 ALSLAR----------ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534

Query: 1886 EKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQR 1945
               E++   +R+++E L+ E++  E+  + +LE + +  ++Q E +      + ++ ++ 
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATED-AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRL 1593

Query: 1946 PYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQL-IDKTTLDKLLKGKKSVEEV 2004
                 RE + E E       L     +K    ++  E Q+       D+++K  + ++  
Sbjct: 1594 LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653

Query: 2005 ASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAAT 2055
              + Q        +  A AS  E ++  +   KKL S E+ ++ L+ + A+
Sbjct: 1654 MKDYQ------RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  178 bits (451), Expect = 8e-44
 Identities = 233/1119 (20%), Positives = 478/1119 (42%), Gaps = 158/1119 (14%)

Query: 1001 ARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQ 1060
            A Y++L  R+  ++R  +++ K L  +  +  ++   EEEL   R+       K    + 
Sbjct: 817  AAYLKL--RNWQWWRLFTKV-KPLLQVSRQEEEMMAKEEELVKVRE-------KQLAAEN 866

Query: 1061 NLQKYQAECSQFKA-KLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIE 1119
             L + +   SQ  A KL   E+L+ + EL  + A++   +   + +EL E    L   +E
Sbjct: 867  RLTEMETLQSQLMAEKLQLQEQLQAETELCAE-AEELRARLTAKKQELEEICHDLEARVE 925

Query: 1120 DEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKE-KEYEIERLRVLL 1178
            +E+ R + ++    + + +  +L++  Q E+E    QKL+ EK   E K  ++E  +++L
Sbjct: 926  EEEERCQHLQAEKKKMQQNIQELEE--QLEEEESARQKLQLEKVTTEAKLKKLEEEQIIL 983

Query: 1179 QEEGTR----KREYENELAKVRNHYNEE------MSNLRNKYETEINITKTTIKEISMQK 1228
            +++  +    K+  E+ +A+   +  EE      ++ L+NK+E  I    T ++E   ++
Sbjct: 984  EDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI----TDLEERLRRE 1039

Query: 1229 EDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKA-CGSEIMQK 1287
            E   + L     +L  ++ DL D+I  L   I +   Q  + EE      A    E  QK
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099

Query: 1288 KQHLEI--ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYE 1345
               L+   EL+  + +  ED    + S  +A K  +D  +E+E LK E ++        +
Sbjct: 1100 NMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159

Query: 1346 NELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSL 1405
                            L+++ E E+NI K T+       EE+   + AQI  + +++   
Sbjct: 1160 E---------------LRSKREQEVNILKKTL-------EEEAKTHEAQIQEMRQKHSQA 1197

Query: 1406 SEEI-------KRLKNTLT---QTTENLR-RVEEDIQQQKATGSEVSQRKQQLEVELRQV 1454
             EE+       KR+K  L    QT EN R  +  +++       +   +++++E +L+++
Sbjct: 1198 VEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL 1257

Query: 1455 TQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLID----KETNDRKCLEDENARLQRV 1510
             Q++  E  R +  L D    +Q +   +  L    D    K T D   LE +   LQ  
Sbjct: 1258 -QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ---LQDT 1313

Query: 1511 QYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQ- 1569
            Q  LQ+ N        KLK  E E    R   E   + +   ++ I      + +++ + 
Sbjct: 1314 QELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKM 1373

Query: 1570 -------------KQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLT 1616
                         K+K++++L  L +   E      KLE+    +++ L +  + + +  
Sbjct: 1374 EDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR 1433

Query: 1617 QQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVK 1676
            Q        +K+ +  L +++ +   +  E+ R + E R   ++  +L R L +  E   
Sbjct: 1434 QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA 1493

Query: 1677 QAHLRNEHFQKAIED----------------KSR-----SLNESKIEIERLQSLTENLTK 1715
            +    N+ F+  +ED                KS+      + E K ++E L+   +    
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553

Query: 1716 EHLMLEEELRNLRLEYDDLRRGRSEADSDKNATIL----ELRSQLQISNNRTLELQGLIN 1771
              L LE  L+ ++ +++   +GR E   +K   ++    E+ ++L+    +         
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613

Query: 1772 DLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQE-------RESLLVKIKVLEQ 1824
             L+ + ++L   I+   K   EA  ++++ + Q    ++E       RE +L + K   +
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK---E 1670

Query: 1825 DKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWK-------TQYSRKEEA 1877
            ++ +L+ +E E+ + +  L A  R K++ + E+ ++ +++            +  R E  
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730

Query: 1878 IRKIESEREKSEREKNSLRSEIERLQAEIKRI-------------EERCRRKLEDSTRET 1924
            I ++E E E+ +     +   +++   +I +I              E  R++LE   +E 
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790

Query: 1925 QSQLE----TERSRY-------QREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRK 1973
            + +L+    T +S+Y       + +I +L ++     +E Q  C+    T K + D L +
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQ 1850

Query: 1974 ---KVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ 2009
               +    + Y+ Q    +T  +L + K+ +EE   E Q
Sbjct: 1851 VDDERRNAEQYKDQADKAST--RLKQLKRQLEEAEEEAQ 1887



 Score =  171 bits (432), Expect = 1e-41
 Identities = 224/1093 (20%), Positives = 471/1093 (43%), Gaps = 148/1093 (13%)

Query: 927  LNEQKNLHSEISGKR-DKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985
            L E + L S++  ++    E++Q   ELCA + ++   +L +    LE + +    R   
Sbjct: 868  LTEMETLQSQLMAEKLQLQEQLQAETELCAEA-EELRARLTAKKQELEEICHDLEARVEE 926

Query: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNT----KIEVLEEEL 1041
            +      LQ       + I+ L         L E   + + L+L+      K++ LEEE 
Sbjct: 927  EEERCQHLQAEKKKMQQNIQELEEQ------LEEEESARQKLQLEKVTTEAKLKKLEEEQ 980

Query: 1042 RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELK--------------RQAE 1087
             +  D N +   + K L+  + ++    ++ + K  SL +LK              R+ E
Sbjct: 981  IILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREE 1040

Query: 1088 LDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQ 1147
               +  ++   K  G   +L+++I  L  +I + K +    E+         ++     +
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE-----E 1095

Query: 1148 CEKENLGWQKL-ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSN- 1205
              ++N+  +K+ E E  I E + ++E  R    +   +KR+   EL  ++    + + + 
Sbjct: 1096 AAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST 1155

Query: 1206 -----LRNKYETEINITKTTIKEISMQKEDDSKNLRN-----------QLDRLSRENRDL 1249
                 LR+K E E+NI K T++E +   E   + +R            QL++  R   +L
Sbjct: 1156 AAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215

Query: 1250 ----------KDEIVRLNDSILQA---TEQRRRAEENALQQ--------KACGSEIMQKK 1288
                      + E+      +LQ    +E +R+  E  LQ+        +   +E+  K 
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275

Query: 1289 QHLEIELKQVMQQRSEDNARHKQ----------SLEEAAKTIQDKN----------KEIE 1328
              L++EL  V    S+ +++  +           L++  + +Q++N          K++E
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335

Query: 1329 RLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDT 1388
              K  F+E+ +   E ++ L K       ++  +K + E  +   +T   ++  + ++D 
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA-EEVKRKLQKDL 1394

Query: 1389 SGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRK-QQL 1447
             G    +     E  +  +++++ K  L Q  ++L  V+ D Q+Q A   E  Q+K  QL
Sbjct: 1395 EG----LSQRHEEKVAAYDKLEKTKTRLQQELDDLL-VDLDHQRQSACNLEKKQKKFDQL 1449

Query: 1448 EVELRQVTQM------RTEESVRYKQ----SLDDAAKTIQDKNKEIERLKQLIDKETNDR 1497
              E + ++        R E   R K+    SL  A +   ++  E+ERL +    E  D 
Sbjct: 1450 LAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509

Query: 1498 KCLEDENARLQRVQYDLQKANSSATETINKLKVQEQEL---------TRLRIDYE----R 1544
               +D+   + +  ++L+K+  +  + + ++K Q +EL          +LR++      +
Sbjct: 1510 MSSKDD---VGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566

Query: 1545 VSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRS 1604
               ER ++ +D  + +   K+L  Q +++E EL   ++  S     RKKLE +L+ +   
Sbjct: 1567 AQFERDLQGRD-EQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625

Query: 1605 L------KEQAIK-ITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRL 1657
            +      +++AIK +  L  Q++       R  DD R  R+ +   L + +  +++L+ +
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCM----RELDDTRASREEI---LAQAKENEKKLKSM 1678

Query: 1658 SSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717
             +E+  L+ +L   + + +QA    +     I + S     +  E  RL++    L +E 
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE- 1737

Query: 1718 LMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777
              LEEE  N  L  D L++   + D       LE RS  Q + N   +L+    +L+ + 
Sbjct: 1738 --LEEEQGNTELINDRLKKANLQIDQINTDLNLE-RSHAQKNENARQQLERQNKELKVKL 1794

Query: 1778 ENLRQEIEKFQKQALEASN-RIQESKNQCTQVVQERESLLVKIKVLEQD-KARLQRLEDE 1835
            + +   ++   K ++ A   +I + + Q     +ER++   +++  E+  K  L +++DE
Sbjct: 1795 QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE 1854

Query: 1836 LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSL 1895
               A+   +   +   RL    +Q++  L + + +  R   + RK++ E E +    +++
Sbjct: 1855 RRNAEQYKDQADKASTRL----KQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAM 1910

Query: 1896 RSEIERLQAEIKR 1908
              E+  L+ +++R
Sbjct: 1911 NREVSSLKNKLRR 1923



 Score =  142 bits (359), Expect = 4e-33
 Identities = 204/1056 (19%), Positives = 438/1056 (41%), Gaps = 155/1056 (14%)

Query: 770  VRALLQAILQT-EDMLKVYEARLTEEETVC--------------------LDLDKVEAYR 808
            +RA L A  Q  E++    EAR+ EEE  C                    L+ ++    +
Sbjct: 902  LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961

Query: 809  CGLKKIKNDLNLKKS-----LLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQL 863
              L+K+  +  LKK      +L     +L K +++      ++     +  +  + + +L
Sbjct: 962  LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021

Query: 864  TDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTV 923
             ++ + +   ++ RL   EKQ ++L   R   +       D+    D +  ++   +   
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEG------DSTDLSDQIAELQAQIAELK 1075

Query: 924  MRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRT 983
            M+   +++ L + ++  R + E  QK   +    I++ E Q++     LE+      K  
Sbjct: 1076 MQLAKKEEELQAALA--RVEEEAAQK--NMALKKIRELESQISELQEDLESERASRNKAE 1131

Query: 984  MIQSPSG-------VILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEV 1036
              +   G         L++  D  A   EL ++       L + L+  E+ K    +I+ 
Sbjct: 1132 KQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE--EEAKTHEAQIQE 1189

Query: 1037 LEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQN 1096
            + ++   A +  +E   + K +  NL+K +      + +LA+  ++  Q + D +  ++ 
Sbjct: 1190 MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249

Query: 1097 LDKCYGQIK-----------ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA 1145
            ++    +++           EL +K+T+L  E+++        + +  +   D+  L+  
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ 1309

Query: 1146 RQCEKENL---GWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEE 1202
             Q  +E L     QKL     +K+ E E    R  L+EE   K   E ++A +    + +
Sbjct: 1310 LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL----HAQ 1365

Query: 1203 MSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQ-------LDRLSRENRDLKDEIVR 1255
            +++++ K E  +   +T  +E+  + + D + L  +        D+L +    L+ E   
Sbjct: 1366 VADMKKKMEDSVGCLETA-EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE--- 1421

Query: 1256 LNDSILQATEQRRRAEENALQQKACGSEIMQKK-QHLEIELKQVM------QQRSEDNAR 1308
            L+D ++    QR         Q AC  E  QKK   L  E K +       + R+E  AR
Sbjct: 1422 LDDLLVDLDHQR---------QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472

Query: 1309 HKQ----SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYEN-------ELSKVRNNYDE 1357
             K+    SL  A +   ++  E+ERL  +F+ E +     ++       EL K +   ++
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQ 1532

Query: 1358 EIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLT 1417
            ++  +K Q E E+           ++ E +    +AQ +   +     SEE K+      
Sbjct: 1533 QVEEMKTQLE-ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK------ 1585

Query: 1418 QTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV------TQMRTEESVRYKQSLD- 1470
            Q    +R +E +++ ++   S     +++LE++L+ +           +E+++  + L  
Sbjct: 1586 QLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQA 1645

Query: 1471 ---DAAKTIQDKNKEIERLKQLIDKETNDRKC---------LEDENARLQRVQYDLQKAN 1518
               D  + + D     E +  L   + N++K          L++E A  +R +   Q+  
Sbjct: 1646 QMKDCMRELDDTRASREEI--LAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703

Query: 1519 SSATETI----NKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVE 1574
                + I     K  +  +E  RL     ++ +E   +  +     + LK+  LQ  ++ 
Sbjct: 1704 DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQIN 1763

Query: 1575 EELNRLKRTASEDSCKRKKLE----------EELEGMRRSLKEQAI-----KITNLTQQL 1619
             +LN  +  A ++   R++LE          +E+EG  +S  + +I     KI  L +QL
Sbjct: 1764 TDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQL 1823

Query: 1620 EQASIVK-------KRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQ 1672
            +  +  +       +R+E  L+     +D   R  ++ +++  + S+ ++ L+RQL + +
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883

Query: 1673 ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQS 1708
            E  ++A+      Q+ +ED + + +    E+  L++
Sbjct: 1884 EEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919



 Score =  121 bits (303), Expect = 1e-26
 Identities = 185/919 (20%), Positives = 384/919 (41%), Gaps = 107/919 (11%)

Query: 651  HNKVIETNRENDKQETWMLMELQKIRR-----------QIEHCEGRMTLKNLPLADQGSS 699
            H  +I    E  ++E     EL+K RR           QI   + ++    + LA +   
Sbjct: 1025 HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE 1084

Query: 700  HHITVKINELKSVQNDS-----QAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLE 754
                +   E ++ Q +      + +   +++L++ L + R S      Q    G  ++LE
Sbjct: 1085 LQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLG--EELE 1142

Query: 755  NINGVTDGYLNSLCTVRALLQAILQ--------TEDMLKVYEARLTE--------EETVC 798
             +    +  L+S    + L     Q         E+  K +EA++ E         E + 
Sbjct: 1143 ALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELA 1202

Query: 799  LDLDKVEAYRCGLKKIKNDLNLKKSLLAT-MKTELQ-KAQQIHSQTSQQYPLYDLDLGKF 856
              L++ +  +  L+K K  L  ++  LA  +K  LQ K    H +   +  L +L + KF
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV-KF 1261

Query: 857  --GEKV-TQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLE 913
              GE+V T+L D+  ++  ++D     L +   +      ++ A    L D +       
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321

Query: 914  SMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLE 973
              K   S  + +  +E+ +   ++  + +    ++K        + D + ++      LE
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381

Query: 974  TLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLE-------D 1026
            T     +KR + +   G + Q   +  A Y +L        + L ++L  L+       +
Sbjct: 1382 TAEE--VKRKLQKDLEG-LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438

Query: 1027 LKLKNTKI-EVLEEELRLA------RDANSENCNKNKFLDQNLQKYQAECSQFKAKLASL 1079
            L+ K  K  ++L EE  ++      RD       + +    +L +   E  + KA+L  L
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERL 1498

Query: 1080 EELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139
             +  R    D  S+K ++ K    + EL +    L  ++E+ K + + +ED     ++  
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGK---SVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAK 1555

Query: 1140 DQLQ-----KARQCEKENLGWQKLESEK------AIKEKEYEIERLRVLLQEEGTRKREY 1188
             +L+        Q E++  G  +   EK       ++E E E+E  R         +++ 
Sbjct: 1556 LRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615

Query: 1189 ENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSREN-- 1246
            E +L  +  H +    N R++   ++   +  +K+  M++ DD++  R ++   ++EN  
Sbjct: 1616 EMDLKDLEAHIDSANKN-RDEAIKQLRKLQAQMKD-CMRELDDTRASREEILAQAKENEK 1673

Query: 1247 --RDLKDEIVRLNDSILQATEQRRRAE-------ENALQQKACGSEIMQKKQHLEIELKQ 1297
              + ++ E+++L + +  A   +R+A+       +        G+  +++K+ LE  + Q
Sbjct: 1674 KLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQ 1733

Query: 1298 VMQQRSEDNARHK---QSLEEAAKTIQDKNKE--IERLKAEFQEEAKRRWEYENELSKVR 1352
            + ++  E+    +     L++A   I   N +  +ER  A+  E A+++ E +N+  KV+
Sbjct: 1734 LEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK 1793

Query: 1353 NNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEI--- 1409
                E   ++K++++  I   +  I QL             Q+DN T+E ++  +++   
Sbjct: 1794 --LQEMEGTVKSKYKASITALEAKIAQL-----------EEQLDNETKERQAACKQVRRT 1840

Query: 1410 -KRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQS 1468
             K+LK+ L Q  +  R  E+   Q     + + Q K+QLE E  +  Q       + ++ 
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLE-EAEEEAQRANASRRKLQRE 1899

Query: 1469 LDDAAKTIQDKNKEIERLK 1487
            L+DA +T    N+E+  LK
Sbjct: 1900 LEDATETADAMNREVSSLK 1918



 Score = 56.6 bits (135), Expect = 3e-07
 Identities = 91/471 (19%), Positives = 185/471 (39%), Gaps = 55/471 (11%)

Query: 766  SLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLL 825
            +L   RAL +A+ Q  ++ ++ +   TE E +    D V      L+K K  L  +   +
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ---V 1534

Query: 826  ATMKTELQKAQQIHSQTSQQYPLYDLDL----GKFGEKVTQLTDRWQRIDKQIDFRLWDL 881
              MKT+L++ +     T       +++L     +F   +    ++ +   KQ+  ++ ++
Sbjct: 1535 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594

Query: 882  EKQIKQLRNYRDNYQAFCKWLY----DAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEI 937
            E +++  R  R    A  K L     D +   DS    +      + +   + K+   E+
Sbjct: 1595 EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654

Query: 938  SGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAA 997
               R   EE+   A+     +K  E ++       E L      +   Q     +  E A
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMIQLQ---EELAAAERAKRQAQQERDELADEIA 1711

Query: 998  DVHARYIELLTRSGDYYRFLSEMLKSLED-----------LKLKNTKIEVLEEELRLARD 1046
            +   +    L         ++++ + LE+           LK  N +I+ +  +L L R 
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS 1771

Query: 1047 ANSENCN-------KNKFLDQNLQKYQAEC-SQFKAKLASLEELKRQAELDGKSAKQNLD 1098
               +N N       +NK L   LQ+ +    S++KA + +LE    Q E    +  +   
Sbjct: 1772 HAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQ 1831

Query: 1099 KCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL 1158
                Q++   +K+  +  +++DE+R  +  +D+ D+      QL+  RQ E+     Q+ 
Sbjct: 1832 AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLK--RQLEEAEEEAQRA 1889

Query: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNK 1209
             + +   ++E E                    +  +  +  N E+S+L+NK
Sbjct: 1890 NASRRKLQRELE--------------------DATETADAMNREVSSLKNK 1920



 Score = 32.7 bits (73), Expect = 5.3
 Identities = 53/226 (23%), Positives = 96/226 (42%), Gaps = 40/226 (17%)

Query: 243  REKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKN 302
            R ++ I QLEEE E       E   +   + + ++  + +I  IN   +  L    + KN
Sbjct: 1726 RLEARIAQLEEELE-------EEQGNTELINDRLKKANLQIDQINT--DLNLERSHAQKN 1776

Query: 303  TNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWIL 362
             N  Q          QLE + KEL    QE +  V +++ AS      +  L+ +   I 
Sbjct: 1777 ENARQ----------QLERQNKELKVKLQEMEGTVKSKYKAS------ITALEAK---IA 1817

Query: 363  QITKCIDVHLKENAAYFQFFEEAQSTEAYLKGL--------QDSIRKKYPCDK-NMPLQH 413
            Q+ + +D   KE  A  +   + + TE  LK +        +++ + K   DK +  L+ 
Sbjct: 1818 QLEEQLDNETKERQAACK---QVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874

Query: 414  LLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNK 459
            L  Q++E E+E ++    +R++Q  +  + +      R      NK
Sbjct: 1875 LKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,756,307
Number of Sequences: 37866
Number of extensions: 4454494
Number of successful extensions: 59095
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 686
Number of HSP's successfully gapped in prelim test: 1417
Number of HSP's that attempted gapping in prelim test: 17835
Number of HSP's gapped (non-prelim): 16425
length of query: 2871
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2751
effective length of database: 13,703,598
effective search space: 37698598098
effective search space used: 37698598098
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.